Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ARHGAP4	393	broad.mit.edu	37	X	153184449	153184449	+	Missense_Mutation	SNP	G	G	T			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chrX:153184449G>T	ENST00000370028.3	-	8	1046	c.989C>A	c.(988-990)gCt>gAt	p.A330D	ARHGAP4_ENST00000393721.1_Intron|ARHGAP4_ENST00000350060.5_Missense_Mutation_p.A290D|ARHGAP4_ENST00000537206.1_Missense_Mutation_p.A267D|ARHGAP4_ENST00000370016.1_Missense_Mutation_p.A269D	NM_001164741.1	NP_001158213.1	P98171	RHG04_HUMAN	Rho GTPase activating protein 4	290					apoptosis|cytoskeleton organization|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|Rho protein signal transduction	cytosol|focal adhesion|nucleus	Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			central_nervous_system(2)|endometrium(2)|large_intestine(1)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	14	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GCGGCTCTCAGCGGCCGTGTA	0.642000													7	39					0.00198382	0.00214126	1	1	0
IGKV1-8	28942	broad.mit.edu	37	2	89292054	89292054	+	RNA	SNP	A	A	C			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr2:89292054A>C	ENST00000495489.1	-	0	271																											CACTTTGCAAAGTGGATGCAG	0.493000													6	254					0	0	1	0	0
SLC25A2	83884	broad.mit.edu	37	5	140683125	140683125	+	Missense_Mutation	SNP	T	T	G			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr5:140683125T>G	ENST00000239451.4	-	1	487	c.308A>C	c.(307-309)aAg>aCg	p.K103T		NM_031947.2	NP_114153.1	Q9BXI2	ORNT2_HUMAN	solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2	103					mitochondrial ornithine transport|urea cycle	integral to membrane|mitochondrial inner membrane	L-ornithine transmembrane transporter activity			breast(3)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	19		all_lung(500;0.000249)|Lung NSC(810;0.0011)|Ovarian(839;0.00556)|Breast(839;0.0173)|all_hematologic(541;0.152)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.00204)	L-Ornithine(DB00129)	ATCACTCAGCTTTGCCTGCTT	0.577000													8	115					0	0	1	0	0
ADCY8	114	broad.mit.edu	37	8	132052065	132052065	+	Missense_Mutation	SNP	C	C	A			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr8:132052065C>A	ENST00000286355.5	-	1	2607	c.515G>T	c.(514-516)cGc>cTc	p.R172L	ADCY8_ENST00000377928.3_Missense_Mutation_p.R172L	NM_001115.2	NP_001106.1	P40145	ADCY8_HUMAN	adenylate cyclase 8 (brain)	172					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding	p.R172H(1)		NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(21)|lung(67)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(5)|urinary_tract(2)	134	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			CAAGAAATAGCGCTGGTAGAG	0.532000										HNSCC(32;0.087)			15	75					9.16793e-09	1.17626e-08	1	1	0
PRB2	653247	broad.mit.edu	37	12	11546867	11546867	+	Missense_Mutation	SNP	C	C	A			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr12:11546867C>A	ENST00000389362.4	-	3	180	c.145G>T	c.(145-147)Ggt>Tgt	p.G49C	PRB1_ENST00000546254.1_Intron	NM_006248.3	NP_006239.3			proline-rich protein BstNI subfamily 2									p.?(1)|p.A39_G59delAPPQGGNKPQGPPSPPGKPQG(1)		NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(14)|pancreas(1)|prostate(5)|skin(4)|stomach(2)|urinary_tract(1)	37		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			GATGGGGGACCTTGAGGTTTG	0.552000													27	278					4.06085e-26	5.41447e-26	1	1	0
UBR4	23352	broad.mit.edu	37	1	19420579	19420579	+	Missense_Mutation	SNP	T	T	C			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr1:19420579T>C	ENST00000375267.2	-	95	13804	c.13801A>G	c.(13801-13803)Atc>Gtc	p.I4601V	UBR4_ENST00000375254.3_Missense_Mutation_p.I4601V|UBR4_ENST00000375224.1_Missense_Mutation_p.I308V|UBR4_ENST00000375217.2_Missense_Mutation_p.I4594V|UBR4_ENST00000543981.1_Missense_Mutation_p.I265V|UBR4_ENST00000467272.2_5'UTR|UBR4_ENST00000429347.2_Missense_Mutation_p.I124V|UBR4_ENST00000375226.2_Missense_Mutation_p.I4577V			Q5T4S7	UBR4_HUMAN	ubiquitin protein ligase E3 component n-recognin 4	4601					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		GTGCTGTTGATCTGGTCCAAG	0.517000													7	31					0	0	1	0	0
ST6GALNAC6	30815	broad.mit.edu	37	9	130658593	130658593	+	Silent	SNP	C	C	A			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr9:130658593C>A	ENST00000373146.1	-	3	224	c.45G>T	c.(43-45)ctG>ctT	p.L15L	ST6GALNAC6_ENST00000542456.1_5'UTR|ST6GALNAC6_ENST00000291839.5_Silent_p.L15L|ST6GALNAC6_ENST00000373141.1_5'UTR|ST6GALNAC6_ENST00000373144.3_5'UTR|ST6GALNAC6_ENST00000485320.1_5'UTR|ST6GALNAC6_ENST00000373142.1_Silent_p.L15L			Q969X2	SIA7F_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6	15					protein glycosylation	integral to Golgi membrane|plasma membrane				endometrium(3)|large_intestine(3)|lung(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	14						GCCCTGGGGGCAGGGATGTGG	0.567000													4	71					0.014758	0.0152052	1	1	0
MCL1	4170	broad.mit.edu	37	1	150550932	150550932	+	Missense_Mutation	SNP	C	C	G			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr1:150550932C>G	ENST00000369026.2	-	2	783	c.724G>C	c.(724-726)Gat>Cat	p.D242H	MCL1_ENST00000307940.3_Intron|MCL1_ENST00000464132.1_5'UTR	NM_001197320.1|NM_021960.4	NP_001184249.1|NP_068779.1	Q07820	MCL1_HUMAN	myeloid cell leukemia sequence 1 (BCL2-related)	242					anti-apoptosis|apoptosis|cell fate determination|cellular homeostasis|multicellular organismal development|response to cytokine stimulus	integral to membrane|mitochondrial outer membrane|nucleoplasm	BH3 domain binding|protein binding|protein channel activity|protein heterodimerization activity			endometrium(2)|large_intestine(1)|lung(4)|prostate(1)	8	all_cancers(9;1.69e-53)|all_epithelial(9;1.95e-43)|all_lung(15;1.09e-34)|Lung NSC(24;4.04e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			GATTTCACATCGTCTTCGTTT	0.493000													11	125					0	0	1	0	0
OR2D3	120775	broad.mit.edu	37	11	6942471	6942471	+	Missense_Mutation	SNP	G	G	C			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr11:6942471G>C	ENST00000317834.3	+	1	267	c.239G>C	c.(238-240)aGa>aCa	p.R80T		NM_001004684.1	NP_001004684.1	Q8NGH3	OR2D3_HUMAN	olfactory receptor, family 2, subfamily D, member 3	80					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|large_intestine(7)|lung(12)|prostate(3)|skin(1)|stomach(1)	27		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		TTTTTTCTTAGAAATCTCTCC	0.408000													8	143					0	0	1	0	0
SAMD3	154075	broad.mit.edu	37	6	130497046	130497046	+	Silent	SNP	G	G	T			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr6:130497046G>T	ENST00000532763.1	-	7	885	c.756C>A	c.(754-756)ggC>ggA	p.G252G	SAMD3_ENST00000368134.2_Silent_p.G254G|SAMD3_ENST00000457563.2_Silent_p.G278G|SAMD3_ENST00000439090.2_Silent_p.G254G|SAMD3_ENST00000437477.2_Silent_p.G254G			Q8N6K7	SAMD3_HUMAN	sterile alpha motif domain containing 3	254										breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(3)|lung(15)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	29				GBM - Glioblastoma multiforme(226;0.00594)|OV - Ovarian serous cystadenocarcinoma(155;0.128)		TCCTTGTCTGGCCTCTTCGGT	0.353000													8	241					0.00307968	0.00329792	1	1	0
BTNL8	79908	broad.mit.edu	37	5	180338426	180338426	+	Missense_Mutation	SNP	G	G	A	rs146970792	byFrequency	TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr5:180338426G>A	ENST00000231229.4	+	3	719	c.485G>A	c.(484-486)cGg>cAg	p.R162Q	BTNL8_ENST00000508408.1_Missense_Mutation_p.R162Q|BTNL8_ENST00000533815.2_5'UTR|BTNL8_ENST00000511704.1_Missense_Mutation_p.R46Q|BTNL8_ENST00000505126.1_5'UTR|BTNL8_ENST00000400707.3_Missense_Mutation_p.R37Q|BTNL8_ENST00000340184.4_Missense_Mutation_p.R162Q	NM_001159708.1|NM_024850.2	NP_001153180.1|NP_079126.1	Q6UX41	BTNL8_HUMAN	butyrophilin-like 8	162	Ig-like V-type 2.					integral to membrane				breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(12)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	28	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TGGTTCCCCCGGCCCACAGCG	0.532000													5	315					0	0	1	0	0
SESTD1	91404	broad.mit.edu	37	2	180008414	180008414	+	Missense_Mutation	SNP	C	C	A			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr2:180008414C>A	ENST00000428443.3	-	9	1070	c.754G>T	c.(754-756)Gat>Tat	p.D252Y		NM_178123.4	NP_835224.3	Q86VW0	SESD1_HUMAN	SEC14 and spectrin domains 1	252					regulation of calcium ion transport via voltage-gated calcium channel activity		phosphatidic acid binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding|protein binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|skin(3)	30			OV - Ovarian serous cystadenocarcinoma(117;0.0344)|Epithelial(96;0.0531)|all cancers(119;0.147)			CGGAGTGAATCTAATAATTTC	0.458000													12	127					6.40141e-05	7.3779e-05	1	1	0
GPR1	2825	broad.mit.edu	37	2	207041566	207041566	+	Missense_Mutation	SNP	A	A	T			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr2:207041566A>T	ENST00000407325.2	-	3	768	c.406T>A	c.(406-408)Tat>Aat	p.Y136N	GPR1_ENST00000437420.1_Missense_Mutation_p.Y136N	NM_001098199.1|NM_001261452.1|NM_001261453.1|NM_001261454.1|NM_001261455.1|NM_005279.3	NP_001091669.1|NP_001248381.1|NP_001248382.1|NP_001248383.1|NP_001248384.1|NP_005270.2	P46091	GPR1_HUMAN	G protein-coupled receptor 1	136						integral to plasma membrane	G-protein coupled receptor activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(7)|skin(1)	18		Lung NSC(271;7.93e-06)|Renal(323;0.000147)|Hepatocellular(293;0.000888)		UCEC - Uterine corpus endometrioid carcinoma (47;0.000241)|Epithelial(149;1.91e-37)|STAD - Stomach adenocarcinoma(1183;0.00178)|Lung(261;0.111)|LUSC - Lung squamous cell carcinoma(261;0.184)		AAGTGGATATAGTGGTCCAGG	0.458000													5	83					0	0	1	0	0
KANTR	102723508	broad.mit.edu	37	X	53171997	53171997	+	RNA	SNP	G	G	A			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chrX:53171997G>A	ENST00000604849.1	+	0	560																											CCACATGCTTGCAGTCCATTT	0.502000													4	14					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	186014918	186014918	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr1:186014918C>T	ENST00000271588.4	+	41	6632	c.6403C>T	c.(6403-6405)Ctt>Ttt	p.L2135F	HMCN1_ENST00000367492.2_Missense_Mutation_p.L2135F	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	2135	Ig-like C2-type 19.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						CCCACCTACTCTTACTTGGTT	0.408000													4	85					0	0	1	0	0
HSF5	124535	broad.mit.edu	37	17	56540312	56540312	+	Missense_Mutation	SNP	G	G	C			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr17:56540312G>C	ENST00000323777.3	-	4	1482	c.1373C>G	c.(1372-1374)cCt>cGt	p.P458R		NM_001080439.1	NP_001073908.1	Q4G112	HSF5_HUMAN	heat shock transcription factor family member 5	458						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|ovary(3)|skin(1)	16	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GATGTACTCAGGTGACTGTGG	0.483000													7	187					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11097625	11097625	+	RNA	SNP	G	G	C			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr21:11097625G>C	ENST00000470054.1	-	0	244									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		tggagcagctgggcagacaat	0.557000													5	83					0	0	1	0	0
EXOC6	54536	broad.mit.edu	37	10	94675516	94675516	+	Splice_Site	SNP	C	C	T			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr10:94675516C>T	ENST00000371552.4	+	7	679	c.648_splice	c.e7-1	p.A217_splice	EXOC6_ENST00000497262.1_3'UTR|EXOC6_ENST00000260762.6_Splice_Site_p.A222_splice|EXOC6_ENST00000371547.4_Splice_Site_p.A238_splice|EXOC6_ENST00000443748.2_Splice_Site_p.A222_splice	NM_001013848.2	NP_001013870.1	Q8TAG9	EXOC6_HUMAN	exocyst complex component 6	222					protein transport|vesicle docking involved in exocytosis	exocyst				cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(4)|ovary(1)|skin(1)|urinary_tract(1)	26		Colorectal(252;0.123)				TCAAAATAGGCACAGCATCAG	0.279000													12	69					0	0	1	0	0
LRRIQ4	344657	broad.mit.edu	37	3	169540081	169540081	+	Silent	SNP	G	G	A			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr3:169540081G>A	ENST00000340806.6	+	1	372	c.372G>A	c.(370-372)cgG>cgA	p.R124R		NM_001080460.1	NP_001073929.1	A6NIV6	LRIQ4_HUMAN	leucine-rich repeats and IQ motif containing 4	124										breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	30						GCGAGCTCCGGCTCTACCAGA	0.582000													8	65					0	0	1	0	0
MMP13	4322	broad.mit.edu	37	11	102825259	102825259	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr11:102825259C>T	ENST00000260302.3	-	3	467	c.439G>A	c.(439-441)Gat>Aat	p.D147N	MMP13_ENST00000340273.4_Missense_Mutation_p.D147N	NM_002427.3	NP_002418.1	P45452	MMP13_HUMAN	matrix metallopeptidase 13 (collagenase 3)	147					collagen catabolic process|proteolysis	extracellular space	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(15)|ovary(2)|skin(1)|stomach(1)	27		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0144)		GGAGTTACATCGGACCAAACT	0.353000													5	74					0	0	1	0	0
L3MBTL4	91133	broad.mit.edu	37	18	6215775	6215775	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr18:6215775C>T	ENST00000400104.3	-	11	1044	c.844G>A	c.(844-846)Gca>Aca	p.A282T	L3MBTL4_ENST00000535782.1_Missense_Mutation_p.A95T|L3MBTL4_ENST00000400105.2_Missense_Mutation_p.A282T|L3MBTL4_ENST00000317931.7_Missense_Mutation_p.A282T|L3MBTL4_ENST00000284898.6_Missense_Mutation_p.A282T			Q8NA19	LMBL4_HUMAN	l(3)mbt-like 4 (Drosophila)	282					chromatin modification	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(17)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		Colorectal(10;0.0249)				GCAGGAACTGCATTGGTTTGA	0.343000													8	86					0	0	1	0	0
FRG1BP	284802	broad.mit.edu	37	20	29628243	29628243	+	Missense_Mutation	SNP	T	T	C			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr20:29628243T>C	ENST00000278882.3	+	6	625	c.245T>C	c.(244-246)tTg>tCg	p.L82S	FRG1B_ENST00000358464.4_Missense_Mutation_p.L82S|FRG1B_ENST00000439954.2_Missense_Mutation_p.L87S														p.L82S(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ATGGCTTTGTTGGCCTCAAAT	0.363000													5	196					0	0	1	0	0
LRP1	4035	broad.mit.edu	37	12	57598229	57598229	+	Missense_Mutation	SNP	A	A	G			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr12:57598229A>G	ENST00000243077.3	+	71	11454	c.10988A>G	c.(10987-10989)aAc>aGc	p.N3663S		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	3663	LDL-receptor class A 29.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CAGTGCAACAACACCTTGTGC	0.612000													8	50					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179628974	179628974	+	Silent	SNP	G	G	A			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr2:179628974G>A	ENST00000589042.1	-	43	10268	c.10044C>T	c.(10042-10044)atC>atT	p.I3348I	TTN_ENST00000342992.6_Silent_p.I3348I|TTN_ENST00000460472.2_Silent_p.I3302I|TTN_ENST00000591111.1_Silent_p.I3348I|TTN_ENST00000342175.6_Silent_p.I3302I|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000360870.5_Silent_p.I3348I|TTN_ENST00000359218.5_Silent_p.I3302I|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	3063	Ig-like 20.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAAGCGGGGTGATGATGGCAG	0.463000													5	130					0	0	1	0	0
GPR63	81491	broad.mit.edu	37	6	97246676	97246676	+	Missense_Mutation	SNP	C	C	A			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr6:97246676C>A	ENST00000229955.3	-	2	1277	c.932G>T	c.(931-933)cGt>cTt	p.R311L	GPR63_ENST00000417980.1_Missense_Mutation_p.R311L	NM_001143957.2|NM_030784.3	NP_001137429.1|NP_110411.1	Q9BZJ6	GPR63_HUMAN	G protein-coupled receptor 63	311						integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			kidney(1)|large_intestine(5)|lung(13)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		all_cancers(76;6.89e-05)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.0618)|Colorectal(196;0.0721)		BRCA - Breast invasive adenocarcinoma(108;0.0912)		GGTGAAGGCACGTGTTTTAAA	0.478000													6	61					0.00198382	0.00214126	1	1	0
TDRD5	163589	broad.mit.edu	37	1	179609542	179609542	+	Missense_Mutation	SNP	G	G	T			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr1:179609542G>T	ENST00000444136.1	+	11	2012	c.1762G>T	c.(1762-1764)Gct>Tct	p.A588S	TDRD5_ENST00000367614.1_Missense_Mutation_p.A588S|TDRD5_ENST00000294848.8_Missense_Mutation_p.A588S	NM_001199085.1|NM_001199089.1	NP_001186014.1|NP_001186018.1	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	588					DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			NS(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(44)|ovary(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	77						TCCAGCTCAGGCTATCCCTTG	0.413000													6	125					8.12818e-05	9.28935e-05	1	1	0
STX5	6811	broad.mit.edu	37	11	62592568	62592568	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr11:62592568G>A	ENST00000294179.3	-	8	772	c.619C>T	c.(619-621)Cgg>Tgg	p.R207W	STX5_ENST00000394690.1_Missense_Mutation_p.R153W|STX5_ENST00000377897.4_Missense_Mutation_p.R207W|STX5_ENST00000541317.1_Missense_Mutation_p.R111W	NM_001244666.1|NM_003164.4	NP_001231595.1|NP_003155.2	Q13190	STX5_HUMAN	syntaxin 5	207					intracellular protein transport|retrograde transport, endosome to Golgi|vesicle targeting	ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|nucleus|SNARE complex	protein N-terminus binding|SNAP receptor activity			breast(2)|endometrium(2)|large_intestine(3)|lung(3)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	18						TGCTCTCTCCGGCTCCTCTGC	0.582000													9	61					0	0	1	0	0
ITGBL1	9358	broad.mit.edu	37	13	102220053	102220053	+	Translation_Start_Site	SNP	A	A	T			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr13:102220053A>T	ENST00000545560.2	+	0	269				ITGBL1_ENST00000376180.3_Missense_Mutation_p.H107L|ITGBL1_ENST00000376162.3_Missense_Mutation_p.H14L	NM_001271754.1	NP_001258683.1	O95965	ITGBL_HUMAN	integrin, beta-like 1 (with EGF-like repeat domains)						cell-matrix adhesion|integrin-mediated signaling pathway	extracellular region|integrin complex	binding|receptor activity			breast(1)|large_intestine(6)|lung(16)|ovary(1)|prostate(4)|skin(3)	31	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TCCCCAGGCCATGGTAAGTGT	0.433000													9	134					0	0	1	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76461448	76461448	+	Missense_Mutation	SNP	C	C	A			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr16:76461448C>A	ENST00000307431.8	+	5	872	c.487C>A	c.(487-489)Ccc>Acc	p.P163T	CNTNAP4_ENST00000478060.1_Missense_Mutation_p.P139T|CNTNAP4_ENST00000476707.1_Missense_Mutation_p.P167T|CNTNAP4_ENST00000377504.4_Missense_Mutation_p.P163T|CNTNAP4_ENST00000469589.1_3'UTR	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4	164	F5/8 type C.				cell adhesion|signal transduction	integral to membrane	receptor binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						GGAATGGAACCCCAAGGGCAG	0.413000													12	91					6.40141e-05	7.3779e-05	1	1	0
UNC79	57578	broad.mit.edu	37	14	94120108	94120108	+	Missense_Mutation	SNP	C	C	T	rs148490393		TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr14:94120108C>T	ENST00000553484.1	+	38	6441	c.6287C>T	c.(6286-6288)gCg>gTg	p.A2096V	UNC79_ENST00000256339.4_Missense_Mutation_p.A1897V|UNC79_ENST00000555664.1_Missense_Mutation_p.A2035V|UNC79_ENST00000393151.2_Missense_Mutation_p.A2074V			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	2074						integral to membrane		p.A1897V(1)		breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						CCCGGCAATGCGGCGGGGGTG	0.532000													5	331					0	0	1	0	0
ANKRD30BL	554226	broad.mit.edu	37	2	132912254	132912254	+	Missense_Mutation	SNP	C	C	A			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr2:132912254C>A	ENST00000409867.1	-	4	844	c.595G>T	c.(595-597)Gca>Tca	p.A199S	ANKRD30BL_ENST00000470729.1_5'UTR					ankyrin repeat domain 30B-like											endometrium(1)|kidney(3)	4						TTATCAACTGCATTTGCATTT	0.318000													3	21					0.004672	0.004964	1	1	0
MGAT4C	25834	broad.mit.edu	37	12	86373732	86373732	+	Missense_Mutation	SNP	C	C	A			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr12:86373732C>A	ENST00000604798.1	-	8	1976	c.772G>T	c.(772-774)Ggc>Tgc	p.G258C	MGAT4C_ENST00000552435.2_Intron|MGAT4C_ENST00000393205.2_Missense_Mutation_p.G287C|MGAT4C_ENST00000549405.2_Missense_Mutation_p.G258C|MGAT4C_ENST00000332156.1_Missense_Mutation_p.G258C|MGAT4C_ENST00000552808.2_Missense_Mutation_p.G258C|MGAT4C_ENST00000548651.1_Missense_Mutation_p.G258C			Q9UBM8	MGT4C_HUMAN	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)	258					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(17)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41						CCAATGTAGCCAAGCTTAGAG	0.363000													6	103					1.06961e-07	1.34282e-07	1	1	0
ZNF611	81856	broad.mit.edu	37	19	53210028	53210028	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr19:53210028C>T	ENST00000543227.1	-	6	554	c.280G>A	c.(280-282)Gaa>Aaa	p.E94K	ZNF611_ENST00000453741.2_Missense_Mutation_p.E25K|ZNF611_ENST00000319783.1_Missense_Mutation_p.E94K|ZNF611_ENST00000540744.1_Missense_Mutation_p.E94K|ZNF611_ENST00000595798.1_Missense_Mutation_p.E25K|ZNF611_ENST00000602162.1_Missense_Mutation_p.E25K|ZNF611_ENST00000600943.1_Silent_p.*76*	NM_001161499.1	NP_001154971.1	Q8N823	ZN611_HUMAN	zinc finger protein 611	94	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|lung(12)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				OV - Ovarian serous cystadenocarcinoma(262;0.0233)|GBM - Glioblastoma multiforme(134;0.04)		TGATGACTTTCATGTCTTTGC	0.388000													10	428					0	0	1	0	0
ABCA6	23460	broad.mit.edu	37	17	67129853	67129853	+	Silent	SNP	G	G	A			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr17:67129853G>A	ENST00000284425.2	-	6	894	c.720C>T	c.(718-720)ctC>ctT	p.L240L		NM_080284.2	NP_525023.2	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 6	240					transport	integral to membrane	ATP binding|ATPase activity			breast(6)|endometrium(5)|kidney(17)|large_intestine(18)|lung(20)|ovary(3)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	82	Breast(10;5.65e-12)					TTGTTACATTGAGTGATATAA	0.308000													9	107					0	0	1	0	0
TRIM48	79097	broad.mit.edu	37	11	55036772	55036772	+	Silent	SNP	A	A	C			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr11:55036772A>C	ENST00000417545.2	+	5	719	c.633A>C	c.(631-633)gcA>gcC	p.A211A		NM_024114.3	NP_077019.2	Q8IWZ4	TRI48_HUMAN	tripartite motif containing 48	195						intracellular	zinc ion binding			endometrium(13)|lung(19)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	38						CGCTCAGGGCAGGGCCCATCA	0.498000													9	87					0	0	1	0	0
LZTR1	8216	broad.mit.edu	37	22	21351028	21351028	+	Missense_Mutation	SNP	C	C	T	rs141161152		TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr22:21351028C>T	ENST00000215739.8	+	19	2622	c.2263C>T	c.(2263-2265)Cgg>Tgg	p.R755W	LZTR1_ENST00000479606.1_3'UTR|LZTR1_ENST00000389355.3_Missense_Mutation_p.R736W	NM_006767.3	NP_006758.2	Q8N653	LZTR1_HUMAN	leucine-zipper-like transcription regulator 1	755					anatomical structure morphogenesis		sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(13)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)	42	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			CTACAACAACCGGCTGCAGGC	0.617000													10	50					0	0	1	0	0
PABPC1	26986	broad.mit.edu	37	8	101718959	101718959	+	Missense_Mutation	SNP	C	C	A			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr8:101718959C>A	ENST00000318607.5	-	11	2650	c.1522G>T	c.(1522-1524)Gtt>Ttt	p.V508F	PABPC1_ENST00000522387.1_Missense_Mutation_p.V476F|PABPC1_ENST00000519596.1_Intron|PABPC1_ENST00000519004.1_Missense_Mutation_p.V463F	NM_002568.3	NP_002559.2	P11940	PABP1_HUMAN	poly(A) binding protein, cytoplasmic 1	508					mRNA polyadenylation|mRNA stabilization|negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|translation	catalytic step 2 spliceosome|cytosol	nucleotide binding|poly(A) RNA binding|protein C-terminus binding|translation activator activity			breast(2)|endometrium(4)|kidney(15)|large_intestine(4)|lung(13)|prostate(1)|skin(1)	40	all_cancers(14;6.8e-05)|all_epithelial(15;3.16e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;6.37e-11)|all cancers(13;1.11e-08)|OV - Ovarian serous cystadenocarcinoma(57;3.91e-05)|STAD - Stomach adenocarcinoma(118;0.206)			TACTGTGGAACGGTGCGGACA	0.438000													15	136					1.15088e-07	1.41008e-07	1	1	0
SPANXN2	494119	broad.mit.edu	37	X	142795238	142795238	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chrX:142795238G>A	ENST00000370498.1	-	2	1193	c.440C>T	c.(439-441)tCt>tTt	p.S147F		NM_001009615.1	NP_001009615.1	Q5MJ10	SPXN2_HUMAN	SPANX family, member N2	147								p.S147F(1)|p.K23K(1)		NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(17)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	27	Acute lymphoblastic leukemia(192;6.56e-05)					CTCCTGTGAAGATCCTTCAGA	0.532000													40	281					0	0	1	0	0
MYO7A	4647	broad.mit.edu	37	11	76893069	76893069	+	Missense_Mutation	SNP	G	G	C			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr11:76893069G>C	ENST00000409709.3	+	24	3249	c.2977G>C	c.(2977-2979)Gag>Cag	p.E993Q	MYO7A_ENST00000458637.2_Missense_Mutation_p.E993Q|MYO7A_ENST00000409893.1_Missense_Mutation_p.E993Q|MYO7A_ENST00000409619.2_Missense_Mutation_p.E982Q	NM_000260.3	NP_000251.3	Q13402	MYO7A_HUMAN	myosin VIIA	993					actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						TGACGAGGATGAGGAGGACCT	0.607000													8	61					0	0	1	0	0
TARS	6897	broad.mit.edu	37	5	33461032	33461032	+	Missense_Mutation	SNP	T	T	C			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr5:33461032T>C	ENST00000265112.3	+	12	1587	c.1276T>C	c.(1276-1278)Tcc>Ccc	p.S426P	TARS_ENST00000502553.1_Missense_Mutation_p.S426P|TARS_ENST00000414361.2_Missense_Mutation_p.S305P|TARS_ENST00000541634.1_Missense_Mutation_p.S322P|TARS_ENST00000455217.2_Missense_Mutation_p.S459P	NM_152295.4	NP_689508.3	P26639	SYTC_HUMAN	threonyl-tRNA synthetase	426					threonyl-tRNA aminoacylation	cytosol	ATP binding|protein homodimerization activity|threonine-tRNA ligase activity			NS(1)|biliary_tract(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(7)|lung(11)|ovary(2)|prostate(1)	29					L-Threonine(DB00156)	TCGGCCAAGGTCCTGGCGAGA	0.458000													7	108					0	0	1	0	0
MYNN	55892	broad.mit.edu	37	3	169496709	169496709	+	Silent	SNP	A	A	G			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr3:169496709A>G	ENST00000349841.5	+	3	1083	c.420A>G	c.(418-420)caA>caG	p.Q140Q	MYNN_ENST00000392733.1_Silent_p.Q140Q|MYNN_ENST00000356716.4_Silent_p.Q140Q|RP11-362K14.5_ENST00000602342.1_RNA|MYNN_ENST00000544106.1_Silent_p.Q140Q	NM_018657.4	NP_061127.1	Q9NPC7	MYNN_HUMAN	myoneurin	140						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16	all_cancers(22;9.55e-22)|all_epithelial(15;2.04e-26)|all_lung(20;5.05e-16)|Lung NSC(18;2.19e-15)|Ovarian(172;0.000223)|Breast(254;0.197)		Epithelial(2;4.03e-64)|all cancers(2;2.19e-58)|Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00676)			AATTGAATCAACAGACTTGTC	0.343000													7	77					0	0	1	0	0
ADD3	120	broad.mit.edu	37	10	111881990	111881990	+	Missense_Mutation	SNP	T	T	A			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr10:111881990T>A	ENST00000277900.8	+	9	1448	c.1083T>A	c.(1081-1083)caT>caA	p.H361Q	ADD3_ENST00000356080.4_Missense_Mutation_p.H361Q|ADD3_ENST00000360162.3_Missense_Mutation_p.H361Q	NM_001121.2	NP_001112.2	Q9UEY8	ADDG_HUMAN	adducin 3 (gamma)	361						cytoskeleton	actin binding|calmodulin binding|metal ion binding|structural constituent of cytoskeleton			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	29		Breast(234;0.052)|Lung NSC(174;0.223)		Epithelial(162;4.15e-05)|all cancers(201;0.000587)|BRCA - Breast invasive adenocarcinoma(275;0.0742)		TGGGTTCCCATCAAAAATGGA	0.418000													4	136					0	0	1	0	0
PRDM9	56979	broad.mit.edu	37	5	23509628	23509628	+	Missense_Mutation	SNP	G	G	T			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr5:23509628G>T	ENST00000296682.3	+	3	301	c.119G>T	c.(118-120)tGg>tTg	p.W40L		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	40	KRAB-related.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						AAGGAAGAATGGGCAGAGATG	0.423000										HNSCC(3;0.000094)			13	226					2.61681e-11	3.42199e-11	1	1	0
SLC25A32	81034	broad.mit.edu	37	8	104419870	104419870	+	Nonsense_Mutation	SNP	G	G	T			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr8:104419870G>T	ENST00000297578.4	-	2	463	c.297C>A	c.(295-297)taC>taA	p.Y99*	SLC25A32_ENST00000543107.1_5'UTR	NM_030780.3	NP_110407.2	Q9H2D1	MFTC_HUMAN	solute carrier family 25 (mitochondrial folate carrier), member 32	99					folic acid metabolic process|mitochondrial transport	integral to membrane|mitochondrial inner membrane	binding|folic acid transporter activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(2)	9			OV - Ovarian serous cystadenocarcinoma(57;2.79e-06)|STAD - Stomach adenocarcinoma(118;0.197)		Folic Acid(DB00158)	ACAAGAAAAAGTAGAGTCCCC	0.343000													18	170					6.49762e-13	8.57938e-13	1	1	0
UBD	10537	broad.mit.edu	37	6	29523954	29523954	+	Silent	SNP	G	G	T			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr6:29523954G>T	ENST00000377050.4	-	2	424	c.201C>A	c.(199-201)ggC>ggA	p.G67G	GABBR1_ENST00000355973.3_3'UTR	NM_006398.3	NP_006389.2	O15205	UBD_HUMAN	ubiquitin D	67	Ubiquitin 1.				aggresome assembly|myeloid dendritic cell differentiation|negative regulation of mitotic prometaphase|positive regulation of apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein ubiquitination|response to interferon-gamma|response to tumor necrosis factor|ubiquitin-dependent protein catabolic process	aggresome|cytoplasm|nucleus	proteasome binding			kidney(1)|lung(3)|skin(1)|upper_aerodigestive_tract(1)	6						CTTTGTCAATGCCATAAGATG	0.498000													8	54					0.000157383	0.000175444	1	1	0
XIRP2	129446	broad.mit.edu	37	2	168103427	168103427	+	Missense_Mutation	SNP	C	C	A			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr2:168103427C>A	ENST00000409195.1	+	9	5614	c.5525C>A	c.(5524-5526)aCa>aAa	p.T1842K	XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409273.1_Missense_Mutation_p.T1620K|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.T1842K|XIRP2_ENST00000409756.2_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	1667					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						GGTGATTTGACATCAACCCTA	0.388000													14	109					4.3838e-07	5.27608e-07	1	1	0
FAM86JP	100125556	broad.mit.edu	37	3	125647387	125647387	+	RNA	SNP	G	G	A			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr3:125647387G>A	ENST00000485843.1	+	0	532					NR_024251.1																						ACCAGAAACTGTTTCCCTATG	0.502000													6	189					0	0	1	0	0
DARC	2532	broad.mit.edu	37	1	159175698	159175698	+	Missense_Mutation	SNP	C	C	A			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr1:159175698C>A	ENST00000537147.1	+	3	1312	c.469C>A	c.(469-471)Ctg>Atg	p.L157M	DARC_ENST00000368122.2_Missense_Mutation_p.L157M|DARC_ENST00000368121.2_Missense_Mutation_p.L159M			Q16570	DUFFY_HUMAN	Duffy blood group, atypical chemokine receptor	157					defense response	integral to membrane|plasma membrane	C-C chemokine binding|chemokine receptor activity			large_intestine(2)|lung(1)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	8	all_hematologic(112;0.0429)					GGGCCACAGACTGGGTGCAGG	0.642000													4	38					1	1	1	1	0
SLC13A1	6561	broad.mit.edu	37	7	122755642	122755642	+	Missense_Mutation	SNP	A	A	T			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr7:122755642A>T	ENST00000194130.2	-	15	1757	c.1718T>A	c.(1717-1719)aTt>aAt	p.I573N	SLC13A1_ENST00000539873.1_3'UTR	NM_022444.3	NP_071889.2	Q9BZW2	S13A1_HUMAN	solute carrier family 13 (sodium/sulfate symporter), member 1	573						integral to membrane|plasma membrane	sodium:sulfate symporter activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(20)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	45					Succinic acid(DB00139)	CATGGGTACAATCCAAGTACA	0.433000													10	87					0	0	1	0	0
GABRA2	2555	broad.mit.edu	37	4	46305631	46305631	+	Splice_Site	SNP	T	T	G			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr4:46305631T>G	ENST00000510861.1	-	8	877		c.e8-2		GABRA2_ENST00000515082.1_Splice_Site|GABRA2_ENST00000356504.1_Splice_Site|GABRA2_ENST00000514090.1_Splice_Site|GABRA2_ENST00000507069.1_Splice_Site|GABRA2_ENST00000540012.1_Splice_Site|GABRA2_ENST00000381620.4_Splice_Site			P47869	GBRA2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 2						gamma-aminobutyric acid signaling pathway|neurotransmitter transport|regulation of neurotransmitter levels	cell junction|chloride channel complex|integral to synaptic vesicle membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	56					Alprazolam(DB00404)|Bromazepam(DB01558)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Fludiazepam(DB01567)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TATATTCACCTGGAAGAAAAA	0.328000													4	53					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3216729	3216729	+	Silent	SNP	A	A	G			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr8:3216729A>G	ENST00000520002.1	-	22	3807	c.3252T>C	c.(3250-3252)ctT>ctC	p.L1084L	CSMD1_ENST00000542608.1_Silent_p.L1083L|CSMD1_ENST00000539096.1_Silent_p.L1083L|CSMD1_ENST00000537824.1_Silent_p.L1083L|CSMD1_ENST00000602723.1_Silent_p.L1084L|CSMD1_ENST00000400186.3_Silent_p.L1084L|CSMD1_ENST00000602557.1_Silent_p.L1084L			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	1084	Sushi 6.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CCAGGCAGGTAAGCTTGGTGG	0.557000													10	86					0	0	1	0	0
TUBA3C	7278	broad.mit.edu	37	13	19751433	19751433	+	Silent	SNP	C	C	G			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr13:19751433C>G	ENST00000400113.3	-	4	794	c.690G>C	c.(688-690)ctG>ctC	p.L230L		NM_006001.2	NP_005992.1	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	230					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(4)|prostate(7)|skin(7)|urinary_tract(1)	72		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		TCTGCCCAATCAGGCGATTGA	0.557000													11	172					0	0	1	0	0
BCKDHB	594	broad.mit.edu	37	6	80838926	80838926	+	Missense_Mutation	SNP	T	T	C			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr6:80838926T>C	ENST00000545529.1	+	3	351	c.323T>C	c.(322-324)gTt>gCt	p.V108A	BCKDHB_ENST00000320393.6_Missense_Mutation_p.V108A|BCKDHB_ENST00000486968.1_3'UTR|BCKDHB_ENST00000369760.4_Missense_Mutation_p.V108A|BCKDHB_ENST00000356489.5_Missense_Mutation_p.V108A			P21953	ODBB_HUMAN	branched chain keto acid dehydrogenase E1, beta polypeptide	108					branched chain family amino acid catabolic process	mitochondrial alpha-ketoglutarate dehydrogenase complex	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity|carboxy-lyase activity|protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(10)|upper_aerodigestive_tract(1)	15		all_cancers(76;1.38e-05)|Acute lymphoblastic leukemia(125;1.15e-05)|all_hematologic(105;0.00118)|all_epithelial(107;0.0149)		BRCA - Breast invasive adenocarcinoma(397;0.0291)		AGATGCACTGTTGGCTTGCGA	0.264000													4	199					0	0	1	0	0
L3HYPDH	112849	broad.mit.edu	37	14	59942889	59942889	+	Missense_Mutation	SNP	T	T	C			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr14:59942889T>C	ENST00000247194.4	-	3	835	c.722A>G	c.(721-723)tAt>tGt	p.Y241C	L3HYPDH_ENST00000487285.1_Missense_Mutation_p.Y70C	NM_144581.1	NP_653182.1			L-3-hydroxyproline dehydratase (trans-)																		TATAGTTCCATATAAAAAGGC	0.284000													8	73					0	0	1	0	0
EPB41L3	23136	broad.mit.edu	37	18	5416179	5416179	+	Nonsense_Mutation	SNP	G	G	A			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr18:5416179G>A	ENST00000341928.2	-	13	2045	c.1705C>T	c.(1705-1707)Caa>Taa	p.Q569*	EPB41L3_ENST00000544123.1_Intron|EPB41L3_ENST00000542652.2_Intron|EPB41L3_ENST00000427684.2_Intron|EPB41L3_ENST00000342933.3_Nonsense_Mutation_p.Q569*|EPB41L3_ENST00000542146.1_Intron|EPB41L3_ENST00000540638.2_Intron|EPB41L3_ENST00000400111.3_Intron	NM_012307.2	NP_036439.2	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	569	Spectrin--actin-binding (Potential).				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(52)|ovary(5)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	105						GCCACATCTTGATCCCCTAGG	0.572000													6	106					0	0	1	0	0
PITPNM3	83394	broad.mit.edu	37	17	6441364	6441364	+	Missense_Mutation	SNP	G	G	C			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr17:6441364G>C	ENST00000262483.8	-	2	148	c.61C>G	c.(61-63)Cga>Gga	p.R21G	ACKR6_ENST00000421306.3_Missense_Mutation_p.R21G	NM_031220.3	NP_112497.2																					AGGACATTTCGAAGGTGCCAG	0.547000													12	21					0	0	1	0	0
TUBB8P7	197331	broad.mit.edu	37	16	90162620	90162620	+	RNA	SNP	T	T	G			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr16:90162620T>G	ENST00000564451.1	+	0	1973																											CTAGGTAAAGTGGGGAAGCAG	0.483000													7	184					0	0	1	0	0
LRRC7	57554	broad.mit.edu	37	1	70504623	70504623	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr1:70504623C>T	ENST00000310961.5	+	22	3435	c.3017C>T	c.(3016-3018)cCa>cTa	p.P1006L	LRRC7_ENST00000035383.5_Missense_Mutation_p.P1001L|LRRC7_ENST00000415775.2_Missense_Mutation_p.P285L			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1001						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						CAGTCAGTCCCAATGCTGGAT	0.468000													4	63					0	0	1	0	0
MEX3A	92312	broad.mit.edu	37	1	156047275	156047275	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr1:156047275G>A	ENST00000532414.2	-	2	652	c.653C>T	c.(652-654)cCt>cTt	p.P218L	MEX3A_ENST00000442784.1_5'UTR	NM_001093725.1	NP_001087194.1	A1L020	MEX3A_HUMAN	mex-3 RNA binding family member A	218						cytoplasmic mRNA processing body|nucleus	RNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(3)	9	Hepatocellular(266;0.158)|all_neural(408;0.195)					GGGCAGAGCAGGAGCCACACC	0.667000													4	25					0	0	1	0	0
ARL6IP4	51329	broad.mit.edu	37	12	123467101	123467101	+	Silent	SNP	C	C	T			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr12:123467101C>T	ENST00000392435.2	+	5	1182	c.985C>T	c.(985-987)Ctg>Ttg	p.L329L	ARL6IP4_ENST00000315580.5_Intron|ARL6IP4_ENST00000357866.4_Intron|ARL6IP4_ENST00000439686.2_Intron|ARL6IP4_ENST00000426960.2_Intron|ARL6IP4_ENST00000454885.2_Intron|ARL6IP4_ENST00000453766.2_Intron|RP11-197N18.2_ENST00000540866.2_RNA|ARL6IP4_ENST00000543566.1_Intron|ARL6IP4_ENST00000412505.2_Intron			Q66PJ3	AR6P4_HUMAN	ADP-ribosylation-like factor 6 interacting protein 4	0					RNA splicing	nucleus						all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.11e-05)|Epithelial(86;0.000127)|BRCA - Breast invasive adenocarcinoma(302;0.107)		TGTGGCCCCTCTGCCTGCCAT	0.587000													4	55					0	0	1	0	0
CNTLN	54875	broad.mit.edu	37	9	17330664	17330664	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr9:17330664C>T	ENST00000380647.3	+	9	1460	c.1376C>T	c.(1375-1377)aCg>aTg	p.T459M	CNTLN_ENST00000262360.5_Missense_Mutation_p.T459M|CNTLN_ENST00000425824.1_Missense_Mutation_p.T459M			Q9NXG0	CNTLN_HUMAN	centlein, centrosomal protein	459						centriole|membrane	two-component sensor activity			breast(6)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(10)|lung(17)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	53				GBM - Glioblastoma multiforme(50;6.14e-10)		AGCTTAGAAACGTTAATGGTT	0.294000													12	195					0	0	1	0	0
RBM25	58517	broad.mit.edu	37	14	73538409	73538409	+	Silent	SNP	G	G	T			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr14:73538409G>T	ENST00000261973.7	+	2	345	c.60G>T	c.(58-60)ggG>ggT	p.G20G	RBM25_ENST00000540173.1_Silent_p.G20G|RBM25_ENST00000527432.1_Silent_p.G20G|RBM25_ENST00000526754.1_Silent_p.G20G|RBM25_ENST00000525321.1_Silent_p.G20G	NM_021239.2	NP_067062.1	P49756	RBM25_HUMAN	RNA binding motif protein 25	20					apoptosis|mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome|RNA splicing	cytoplasm|nuclear speck	mRNA binding|nucleotide binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(6)|ovary(2)|pancreas(1)	31				BRCA - Breast invasive adenocarcinoma(234;0.00362)|OV - Ovarian serous cystadenocarcinoma(108;0.0688)		TCCCACCAGGGATCCCACCCC	0.453000													5	77					0.014758	0.0152052	1	1	0
SPATA7	55812	broad.mit.edu	37	14	88892747	88892747	+	Missense_Mutation	SNP	A	A	G			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr14:88892747A>G	ENST00000556553.1	+	6	1007	c.448A>G	c.(448-450)Agt>Ggt	p.S150G	SPATA7_ENST00000356583.5_Missense_Mutation_p.S150G|SPATA7_ENST00000045347.7_Missense_Mutation_p.S182G|SPATA7_ENST00000393545.4_Missense_Mutation_p.S182G			Q9P0W8	SPAT7_HUMAN	spermatogenesis associated 7	182					response to stimulus|visual perception					cervix(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)	18						CTCCCCGTCCAGTGTGGATTA	0.512000													17	123					0	0	1	0	0
SLITRK3	22865	broad.mit.edu	37	3	164906037	164906037	+	Missense_Mutation	SNP	C	C	A			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr3:164906037C>A	ENST00000475390.1	-	2	3025	c.2582G>T	c.(2581-2583)cGc>cTc	p.R861L	SLITRK3_ENST00000241274.3_Missense_Mutation_p.R861L			O94933	SLIK3_HUMAN	SLIT and NTRK-like family, member 3	861						integral to membrane				NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(66)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(5)	119						CTCATGGTGGCGGAACCCTGC	0.582000										HNSCC(40;0.11)			6	96					0.0215528	0.0220389	1	1	0
PTPRK	5796	broad.mit.edu	37	6	128306869	128306869	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr6:128306869C>T	ENST00000368227.3	-	23	3665	c.3299G>A	c.(3298-3300)tGc>tAc	p.C1100Y	PTPRK_ENST00000368226.4_Missense_Mutation_p.C1083Y|PTPRK_ENST00000368215.3_Missense_Mutation_p.C1082Y|PTPRK_ENST00000368213.5_Missense_Mutation_p.C1089Y|PTPRK_ENST00000368207.3_Missense_Mutation_p.C1115Y|PTPRK_ENST00000532331.1_Missense_Mutation_p.C1105Y|PTPRK_ENST00000368210.3_Missense_Mutation_p.C1101Y			Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	1082	Tyrosine-protein phosphatase 1.				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity		PTPRK/RSPO3(10)	autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(14)|lung(24)|ovary(3)|pancreas(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	72				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		CACTTACCTGCAATGTACAAC	0.468000													5	50					0	0	1	0	0
FAM86JP	100125556	broad.mit.edu	37	3	125647396	125647396	+	RNA	SNP	T	T	C			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr3:125647396T>C	ENST00000485843.1	+	0	541					NR_024251.1																						TGTTTCCCTATGAAGAGCACT	0.502000													6	193					0	0	1	0	0
DLG4	1742	broad.mit.edu	37	17	7099579	7099579	+	Missense_Mutation	SNP	C	C	A			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr17:7099579C>A	ENST00000399510.2	-	13	2242	c.1390G>T	c.(1390-1392)Gcg>Tcg	p.A464S	DLG4_ENST00000302955.6_Missense_Mutation_p.A418S|DLG4_ENST00000399506.2_Missense_Mutation_p.A421S	NM_001365.3	NP_001356.1	P78352	DLG4_HUMAN	discs, large homolog 4 (Drosophila)	421	SH3.				axon guidance|learning|protein complex assembly|protein localization to synapse|signal transduction|synaptic transmission	cell junction|cortical cytoskeleton|endocytic vesicle membrane|neuron spine|postsynaptic density|postsynaptic membrane|synaptosome	protein binding|protein C-terminus binding			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)	18						CGCAGGGACGCAGTCCCTGAG	0.602000													6	67					2.7689e-08	3.51934e-08	1	1	0
ROCK1P1	727758	broad.mit.edu	37	18	117158	117158	+	RNA	SNP	A	A	G			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr18:117158A>G	ENST00000576266.1	+	0	383																											CCTACACTCTACCACTTTCCT	0.438000													5	33					0	0	1	0	0
NUP205	23165	broad.mit.edu	37	7	135328051	135328051	+	Missense_Mutation	SNP	A	A	T			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr7:135328051A>T	ENST00000285968.6	+	39	5530	c.5504A>T	c.(5503-5505)cAg>cTg	p.Q1835L		NM_015135.2	NP_055950.1	Q92621	NU205_HUMAN	nucleoporin 205kDa	1835					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(4)|central_nervous_system(2)|endometrium(9)|kidney(7)|large_intestine(17)|liver(4)|lung(36)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	93						AGTCATCGACAGAGTGTCAGC	0.448000													10	77					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82584423	82584423	+	Missense_Mutation	SNP	C	C	A			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr7:82584423C>A	ENST00000423517.2	-	5	6183	c.5846G>T	c.(5845-5847)gGg>gTg	p.G1949V	PCLO_ENST00000333891.8_Missense_Mutation_p.G1949V	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	1880					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TATTAGCATCCCACCATACAA	0.368000													4	70					0.150653	0.151769	1	1	0
DNM1P47	100216544	broad.mit.edu	37	15	102304772	102304772	+	RNA	SNP	T	T	C			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr15:102304772T>C	ENST00000561463.1	+	0	12818																											CACAGCGGCGTGACGAGACTC	0.587000													4	27					0	0	1	0	0
NRDE2	55051	broad.mit.edu	37	14	90755014	90755014	+	Missense_Mutation	SNP	C	C	T	rs149141901	byFrequency	TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr14:90755014C>T	ENST00000354366.3	-	11	2937	c.2705G>A	c.(2704-2706)cGc>cAc	p.R902H	NRDE2_ENST00000357904.3_Missense_Mutation_p.R671H	NM_017970.3	NP_060440.2			NRDE-2, necessary for RNA interference, domain containing																		GCTAATTAGGCGGCTACAGGA	0.483000													5	54					0	0	1	0	0
HLA-V	352962	broad.mit.edu	37	6	29761676	29761676	+	RNA	SNP	C	C	G			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr6:29761676C>G	ENST00000457107.1	+	0	902																											gagagggtttcatattcaaga	0.493000													3	27					0	0	1	0	0
S1PR1	1901	broad.mit.edu	37	1	101705578	101705578	+	Silent	SNP	C	C	T			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr1:101705578C>T	ENST00000305352.6	+	2	1413	c.1038C>T	c.(1036-1038)gcC>gcT	p.A346A		NM_001400.4	NP_001391.2	P21453	S1PR1_HUMAN	sphingosine-1-phosphate receptor 1	346					cell adhesion	integral to membrane	lysosphingolipid and lysophosphatidic acid receptor activity			NS(1)|autonomic_ganglia(1)|breast(1)|large_intestine(7)|lung(23)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(4)	43						CCATCATCGCCGGCATGGAAT	0.552000													10	166					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126372252	126372252	+	Missense_Mutation	SNP	C	C	A	rs61163957		TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr4:126372252C>A	ENST00000394329.3	+	9	10094	c.10081C>A	c.(10081-10083)Ctt>Att	p.L3361I	FAT4_ENST00000335110.5_Missense_Mutation_p.L1659I	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	3361	Cadherin 32.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.L3361V(2)		NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						TTCTGGAATTCTTGATCGAGA	0.403000													12	162					4.3838e-07	5.27608e-07	1	1	0
APC	324	broad.mit.edu	37	5	112174647	112174647	+	Missense_Mutation	SNP	A	A	G			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr5:112174647A>G	ENST00000457016.1	+	16	3736	c.3356A>G	c.(3355-3357)cAt>cGt	p.H1119R	CTC-554D6.1_ENST00000520401.1_Intron|APC_ENST00000508376.2_Missense_Mutation_p.H1119R|APC_ENST00000257430.4_Missense_Mutation_p.H1119R			P25054	APC_HUMAN	adenomatous polyposis coli	1119	Responsible for down-regulation through a process mediated by direct ubiquitination.|Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.?(1)		NS(7)|adrenal_gland(6)|biliary_tract(5)|bone(6)|breast(29)|central_nervous_system(12)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(2768)|liver(15)|lung(39)|oesophagus(1)|ovary(12)|pancreas(27)|prostate(15)|salivary_gland(2)|skin(14)|small_intestine(34)|soft_tissue(55)|stomach(136)|thyroid(22)|upper_aerodigestive_tract(8)|urinary_tract(20)	3261		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		GGTTCTAATCATGGAATTAAT	0.408000		12	"""D, Mis, N, F, S"""		"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""	"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""			Turcot syndrome;Hereditary Desmoid Disease;Familial Adenomatous Polyposis	TSP Lung(16;0.13)			9	80					0	0	1	0	0
HLA-A	3105	broad.mit.edu	37	6	29912156	29912156	+	Missense_Mutation	SNP	C	C	A	rs149871311		TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr6:29912156C>A	ENST00000396634.1	+	6	1218	c.877C>A	c.(877-879)Ccc>Acc	p.P293T	HLA-A_ENST00000376809.5_Missense_Mutation_p.P293T|HLA-A_ENST00000376802.2_Missense_Mutation_p.P293T|HLA-A_ENST00000376806.5_Missense_Mutation_p.P293T			P30443	1A01_HUMAN	major histocompatibility complex, class I, A	293	Alpha-3.|Ig-like C1-type.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity			central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	30						TCTGCCCAAGCCCCTCACCCT	0.602000									Osteosarcoma, Familial Clustering of;Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of;Melanoma, Familial Clustering of;Lichen Sclerosis et Atrophicus, Familial Clustering of	Multiple Myeloma(9;0.094)			11	90					1.08611e-07	1.34282e-07	1	1	0
SHC4	399694	broad.mit.edu	37	15	49148244	49148244	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr15:49148244G>A	ENST00000332408.4	-	8	1576	c.1148C>T	c.(1147-1149)cCa>cTa	p.P383L	SHC4_ENST00000537958.1_Missense_Mutation_p.P97L|SHC4_ENST00000396535.3_Missense_Mutation_p.P140L	NM_203349.3	NP_976224.3	Q6S5L8	SHC4_HUMAN	SHC (Src homology 2 domain containing) family, member 4	383	CH1.				intracellular signal transduction	cell junction|postsynaptic membrane				breast(1)|endometrium(2)|large_intestine(8)|lung(11)|ovary(3)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)	29		all_lung(180;0.00466)		all cancers(107;9.4e-08)|GBM - Glioblastoma multiforme(94;5.94e-07)		ACCTACTGGTGGCTGCTTCCC	0.438000													9	135					0	0	1	0	0
CYFIP2	26999	broad.mit.edu	37	5	156741411	156741411	+	Silent	SNP	C	C	T	rs139943836	by1000genomes	TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr5:156741411C>T	ENST00000347377.6	+	12	1601	c.1170C>T	c.(1168-1170)ttC>ttT	p.F390F	CYFIP2_ENST00000377576.3_Silent_p.F390F|CYFIP2_ENST00000318218.6_Silent_p.F390F|CYFIP2_ENST00000522463.1_Silent_p.F194F|CYFIP2_ENST00000541131.1_Silent_p.F315F|CYFIP2_ENST00000521420.1_Silent_p.F364F|CYFIP2_ENST00000442283.2_5'UTR|CYFIP2_ENST00000435847.2_Silent_p.F64F	NM_001037332.2	NP_001032409.2	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	390					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding			breast(1)|endometrium(12)|kidney(2)|lung(23)	38	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GCGAGCTCTTCGACCTAGCCC	0.597000													4	69					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141459330	141459330	+	Missense_Mutation	SNP	G	G	T			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr2:141459330G>T	ENST00000389484.3	-	40	7358	c.6387C>A	c.(6385-6387)aaC>aaA	p.N2129K		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	2129					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CCTCCTTCAGGTTGACTCCAA	0.398000										TSP Lung(27;0.18)			11	131					0.00010058	0.000113991	1	1	0
LGI2	55203	broad.mit.edu	37	4	25005442	25005442	+	Silent	SNP	C	C	T			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr4:25005442C>T	ENST00000382114.4	-	8	1454	c.1269G>A	c.(1267-1269)gtG>gtA	p.V423V		NM_018176.3	NP_060646.2	Q8N0V4	LGI2_HUMAN	leucine-rich repeat LGI family, member 2	423						extracellular region				breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(15)|prostate(1)|skin(3)|stomach(2)	33		Breast(46;0.173)				GGAAGCTCTTCACAGCCAGTA	0.537000													20	393					0	0	1	0	0
ADAMTS14	140766	broad.mit.edu	37	10	72489903	72489903	+	Missense_Mutation	SNP	C	C	A			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr10:72489903C>A	ENST00000373208.1	+	6	1000	c.1000C>A	c.(1000-1002)Cag>Aag	p.Q334K	ADAMTS14_ENST00000373207.1_Missense_Mutation_p.Q334K	NM_139155.2	NP_631894.2	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 14	334	Peptidase M12B.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(15)|ovary(7)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50						CAGCCTGGAGCAGGTGTGTCG	0.667000													10	63					1.08611e-07	1.34282e-07	1	1	0
ARSK	153642	broad.mit.edu	37	5	94939042	94939042	+	Missense_Mutation	SNP	A	A	C			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr5:94939042A>C	ENST00000380009.4	+	8	1628	c.1423A>C	c.(1423-1425)Aaa>Caa	p.K475Q		NM_198150.2	NP_937793.1	Q6UWY0	ARSK_HUMAN	arylsulfatase family, member K	475						extracellular region	arylsulfatase activity|metal ion binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|pancreas(1)|skin(1)	16		all_cancers(142;3.38e-06)|all_epithelial(76;6.57e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.00473)		all cancers(79;6.5e-16)		AAACTACCCTAAAGTTTCTGC	0.333000													7	56					0	0	1	0	0
TCEAL2	140597	broad.mit.edu	37	X	101381930	101381930	+	Missense_Mutation	SNP	A	A	G			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chrX:101381930A>G	ENST00000372780.1	+	3	347	c.128A>G	c.(127-129)aAc>aGc	p.N43S	TCEAL2_ENST00000329035.2_Missense_Mutation_p.N43S	NM_080390.3	NP_525129.1	Q9H3H9	TCAL2_HUMAN	transcription elongation factor A (SII)-like 2	43					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|biliary_tract(1)|breast(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)	11						AAGTTAGAAAACGAGGGAAAC	0.453000													6	34					0	0	1	0	0
FNIP1	96459	broad.mit.edu	37	5	130987629	130987629	+	Missense_Mutation	SNP	T	T	A			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr5:130987629T>A	ENST00000307968.7	-	15	3087	c.3088A>T	c.(3088-3090)Act>Tct	p.T1030S	FNIP1_ENST00000510461.1_Missense_Mutation_p.T1058S|FNIP1_ENST00000307954.8_Missense_Mutation_p.T1013S|FNIP1_ENST00000514667.1_Intron	NM_001008738.2	NP_001008738.2			folliculin interacting protein 1											NS(1)|breast(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(11)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34		all_cancers(142;0.00347)|Lung NSC(810;0.106)|all_lung(232;0.123)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0665)		ACTTGAACAGTCCATTTATCC	0.383000													9	98					0	0	1	0	0
PRKCB	5579	broad.mit.edu	37	16	24104219	24104219	+	Missense_Mutation	SNP	A	A	G			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr16:24104219A>G	ENST00000303531.7	+	6	789	c.637A>G	c.(637-639)Aaa>Gaa	p.K213E	PRKCB_ENST00000321728.7_Missense_Mutation_p.K213E|PRKCB_ENST00000482000.1_3'UTR	NM_002738.6	NP_002729.2	P05771	KPCB_HUMAN	protein kinase C, beta	213	C2.				apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding			central_nervous_system(3)|large_intestine(1)|lung(2)|ovary(3)	9					Vitamin E(DB00163)	ACAGAAGACCAAAACCATCAA	0.458000													5	111					0	0	1	0	0
LTBP4	8425	broad.mit.edu	37	19	41133153	41133153	+	Missense_Mutation	SNP	A	A	T			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr19:41133153A>T	ENST00000308370.7	+	32	4457	c.4457A>T	c.(4456-4458)gAg>gTg	p.E1486V	LTBP4_ENST00000602240.1_3'UTR|LTBP4_ENST00000204005.9_Missense_Mutation_p.E1449V|LTBP4_ENST00000243562.9_3'UTR|LTBP4_ENST00000396819.3_Missense_Mutation_p.E1419V|LTBP4_ENST00000545697.1_Missense_Mutation_p.E854V	NM_001042544.1	NP_001036009.1	Q8N2S1	LTBP4_HUMAN	latent transforming growth factor beta binding protein 4	1487	Pro-rich.				growth hormone secretion|multicellular organismal development|protein folding|regulation of cell differentiation|regulation of cell growth|regulation of proteolysis|regulation of transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|glycosaminoglycan binding|integrin binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			central_nervous_system(1)	1			Lung(22;0.000158)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GGCGAATCTGAGGCTCCTGCG	0.701000													5	20					0	0	1	0	0
NTRK3	4916	broad.mit.edu	37	15	88423650	88423650	+	Missense_Mutation	SNP	G	G	T			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr15:88423650G>T	ENST00000394480.1	-	18	2464	c.2143C>A	c.(2143-2145)Cac>Aac	p.H715N	NTRK3_ENST00000360948.2_Missense_Mutation_p.H729N|NTRK3_ENST00000557856.1_Missense_Mutation_p.H707N|NTRK3_ENST00000355254.2_Missense_Mutation_p.H715N|NTRK3_ENST00000357724.2_Missense_Mutation_p.H721N	NM_001243101.1|NM_002530.3	NP_001230030.1|NP_002521.2	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	729	Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(238)	breast(3)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(22)|lung(63)|ovary(6)|pancreas(3)|prostate(1)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)	119			BRCA - Breast invasive adenocarcinoma(143;0.211)			AGCATGGTGTGTCCTCCCACC	0.507000			T	ETV6	"""congenital fibrosarcoma, Secretory breast """					TSP Lung(13;0.10)			5	28					0.000602214	0.000665863	1	1	0
ZNF608	57507	broad.mit.edu	37	5	123982540	123982540	+	Silent	SNP	C	C	T			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr5:123982540C>T	ENST00000306315.5	-	4	3972	c.3537G>A	c.(3535-3537)gaG>gaA	p.E1179E	ZNF608_ENST00000504926.1_Silent_p.E752E	NM_020747.2	NP_065798.2	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	1179						intracellular	zinc ion binding			breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(12)|ovary(3)|skin(6)|urinary_tract(1)	46		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		ATTTACCTGTCTCCTCAGTTT	0.473000													6	151					0	0	1	0	0
NOBOX	135935	broad.mit.edu	37	7	144098481	144098481	+	Missense_Mutation	SNP	G	G	T			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr7:144098481G>T	ENST00000467773.1	-	4	501	c.502C>A	c.(502-504)Cac>Aac	p.H168N	NOBOX_ENST00000483238.1_Missense_Mutation_p.H168N|NOBOX_ENST00000223140.5_Missense_Mutation_p.H83N	NM_001080413.3	NP_001073882.3	O60393	NOBOX_HUMAN	NOBOX oogenesis homeobox	168					cell differentiation|oogenesis	nucleus	sequence-specific DNA binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)	26	Melanoma(164;0.14)					CTGTCTTTGTGGGGAGCCCTG	0.617000													4	45					0.150653	0.151769	1	1	0
MFAP3L	9848	broad.mit.edu	37	4	170913248	170913248	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr4:170913248G>A	ENST00000361618.3	-	3	818	c.511C>T	c.(511-513)Cgc>Tgc	p.R171C	RP11-6E9.4_ENST00000508955.1_RNA|MFAP3L_ENST00000393704.3_Missense_Mutation_p.R68C	NM_021647.6	NP_067679.6	O75121	MFA3L_HUMAN	microfibrillar-associated protein 3-like	171						integral to membrane|plasma membrane		p.R171S(1)		cervix(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22		Prostate(90;0.00601)|Renal(120;0.0183)|all_neural(102;0.122)|Melanoma(52;0.17)		GBM - Glioblastoma multiforme(119;0.0201)|LUSC - Lung squamous cell carcinoma(193;0.116)		ATGCACAGGCGGGTGATATTG	0.512000													14	112					0	0	1	0	0
MSANTD2	79684	broad.mit.edu	37	11	124670231	124670231	+	Nonsense_Mutation	SNP	T	T	A			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr11:124670231T>A	ENST00000239614.4	-	1	338	c.46A>T	c.(46-48)Aaa>Taa	p.K16*	MSANTD2_ENST00000524950.1_Nonsense_Mutation_p.K16*|MSANTD2_ENST00000374979.3_Nonsense_Mutation_p.K16*	NM_024631.2	NP_078907.2	Q6P1R3	CK061_HUMAN	Myb/SANT-like DNA-binding domain containing 2	16																	TTCGGAATTTTTAGCGGCGAG	0.687000													3	25					0	0	1	0	0
OCLN	100506658	broad.mit.edu	37	5	68805003	68805003	+	Missense_Mutation	SNP	A	A	G			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr5:68805003A>G	ENST00000355237.2	+	3	522	c.86A>G	c.(85-87)tAt>tGt	p.Y29C	OCLN_ENST00000380766.2_Missense_Mutation_p.Y29C|OCLN_ENST00000396442.2_Missense_Mutation_p.Y29C|OCLN_ENST00000542132.1_Intron|OCLN_ENST00000538151.1_Intron	NM_002538.3	NP_002529.1	Q16625	OCLN_HUMAN	occludin	29					cellular component disassembly involved in apoptosis|protein complex assembly	integral to membrane|tight junction	protein binding|structural molecule activity			endometrium(2)|large_intestine(1)|liver(1)|prostate(1)|skin(1)	6		Lung NSC(167;4.15e-05)|Prostate(74;0.00996)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;3.04e-60)|Epithelial(20;7.09e-58)|all cancers(19;1.13e-53)|Lung(70;0.0174)		AATGACATATATGGTGGAGAG	0.388000													5	157					0	0	1	0	0
LPIN1	23175	broad.mit.edu	37	2	11943120	11943120	+	Silent	SNP	C	C	T			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr2:11943120C>T	ENST00000256720.2	+	14	1959	c.1866C>T	c.(1864-1866)gtC>gtT	p.V622V	LPIN1_ENST00000404113.2_Silent_p.V123V|LPIN1_ENST00000449576.2_Silent_p.V707V|LPIN1_ENST00000396099.1_Silent_p.V664V|LPIN1_ENST00000396097.1_Silent_p.V352V|LPIN1_ENST00000425416.2_Silent_p.V628V	NM_145693.2	NP_663731.1	Q14693	LPIN1_HUMAN	lipin 1	622					fatty acid catabolic process|transcription, DNA-dependent|triglyceride biosynthetic process|triglyceride mobilization	cytosol|endoplasmic reticulum membrane	phosphatidate phosphatase activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(15)|liver(1)|lung(10)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	45	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.11)|OV - Ovarian serous cystadenocarcinoma(76;0.173)		TGCCTAATGTCAGCTACAAGA	0.552000													6	207					0	0	1	0	0
AK5	26289	broad.mit.edu	37	1	77763264	77763264	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr1:77763264G>A	ENST00000344720.5	+	4	1384	c.358G>A	c.(358-360)Ggt>Agt	p.G120S	AK5_ENST00000317704.4_3'UTR|AK5_ENST00000354567.2_Missense_Mutation_p.G146S	NM_012093.3	NP_036225.2	Q9Y6K8	KAD5_HUMAN	adenylate kinase 5	146					ADP biosynthetic process|ATP metabolic process|dADP biosynthetic process|nucleobase, nucleoside and nucleotide interconversion|pyrimidine ribonucleotide biosynthetic process|signal transduction	centrosome|cytosol	adenylate kinase activity|ATP binding|cAMP-dependent protein kinase regulator activity|nucleoside kinase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(27)|prostate(1)|skin(2)|stomach(1)	40						AAGTGGAAAGGGTACTCAGAG	0.388000													9	110					0	0	1	0	0
LAMB4	22798	broad.mit.edu	37	7	107704425	107704425	+	Nonsense_Mutation	SNP	G	G	A			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr7:107704425G>A	ENST00000388781.3	-	22	2925	c.2842C>T	c.(2842-2844)Cag>Tag	p.Q948*	LAMB4_ENST00000388780.3_Nonsense_Mutation_p.Q948*|LAMB4_ENST00000205386.4_Nonsense_Mutation_p.Q948*	NM_007356.2	NP_031382.2	A4D0S4	LAMB4_HUMAN	laminin, beta 4	948	Laminin EGF-like 9.				cell adhesion	basement membrane				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(22)|lung(40)|ovary(4)|prostate(5)|skin(4)	97						TCTCCACACTGAGTACCTGAA	0.448000													4	80					0	0	1	0	0
EIF5A	1984	broad.mit.edu	37	17	7214723	7214723	+	Nonsense_Mutation	SNP	C	C	T			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr17:7214723C>T	ENST00000336458.8	+	4	726	c.325C>T	c.(325-327)Cga>Tga	p.R109*	GPS2_ENST00000391950.3_3'UTR|EIF5A_ENST00000419711.2_Nonsense_Mutation_p.R109*|EIF5A_ENST00000573542.1_Nonsense_Mutation_p.R109*|EIF5A_ENST00000336452.7_Nonsense_Mutation_p.R139*|EIF5A_ENST00000572815.1_Nonsense_Mutation_p.R109*|EIF5A_ENST00000576930.1_Nonsense_Mutation_p.R109*|EIF5A_ENST00000571955.1_Nonsense_Mutation_p.R109*|EIF5A_ENST00000416016.2_Nonsense_Mutation_p.R109*	NM_001970.4	NP_001961.1	P63241	IF5A1_HUMAN	eukaryotic translation initiation factor 5A	109				R -> P (in Ref. 3; AAD14095).	induction of apoptosis|mRNA export from nucleus|peptidyl-lysine modification to hypusine|positive regulation of cell proliferation|positive regulation of translational elongation|positive regulation of translational termination|post-translational protein modification|protein export from nucleus|translational frameshifting|transmembrane transport	annulate lamellae|cytosol|endoplasmic reticulum membrane|nuclear pore	protein N-terminus binding|ribosome binding|translation elongation factor activity|U6 snRNA binding			endometrium(2)|kidney(1)|large_intestine(2)|urinary_tract(1)	6						CGGGGAGGTACGAGAGGACCT	0.582000													16	76					0	0	1	0	0
PRR14	78994	broad.mit.edu	37	16	30667506	30667506	+	Missense_Mutation	SNP	G	G	T			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr16:30667506G>T	ENST00000542965.2	+	11	2088	c.1632G>T	c.(1630-1632)agG>agT	p.R544S	PRR14_ENST00000300835.4_Missense_Mutation_p.R544S			Q9BWN1	PRR14_HUMAN	proline rich 14	544										breast(3)|endometrium(5)|kidney(1)|large_intestine(3)|lung(5)|skin(1)	18			Colorectal(24;0.103)			CAGGGGGCAGGACTGTTCCTC	0.642000													5	102					0.014758	0.0152052	1	1	0
RPS25	6230	broad.mit.edu	37	11	118888251	118888251	+	Nonsense_Mutation	SNP	C	C	T			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr11:118888251C>T	ENST00000527673.1	-	3	509	c.104G>A	c.(103-105)tGg>tAg	p.W35*		NM_001028.2	NP_001019.1	P62851	RS25_HUMAN	ribosomal protein S25	35					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleolus	protein binding|RNA binding			endometrium(1)	1	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_neural(223;0.112)|all_hematologic(192;0.207)		BRCA - Breast invasive adenocarcinoma(274;7.55e-05)		GCCTTTGGACCACTTCTGCTC	0.408000													13	82					0	0	1	0	0
SON	6651	broad.mit.edu	37	21	34922188	34922188	+	Silent	SNP	A	A	G			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr21:34922188A>G	ENST00000356577.4	+	3	1126	c.651A>G	c.(649-651)gtA>gtG	p.V217V	SON_ENST00000300278.4_Silent_p.V217V|SON_ENST00000381679.4_Silent_p.V217V|SON_ENST00000381692.2_Intron|SON_ENST00000290239.6_Silent_p.V217V	NM_138927.1	NP_620305.1	P18583	SON_HUMAN	SON DNA binding protein	217					anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			breast(3)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(25)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	72						TGTCAGTTGTATCTACATCAG	0.458000											OREG0003564	type=REGULATORY REGION|Gene=AK074269|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	13	135					0	0	1	0	0
HNRNPA3	220988	broad.mit.edu	37	2	178083789	178083789	+	Missense_Mutation	SNP	A	A	C			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr2:178083789A>C	ENST00000411529.2	+	9	971	c.920A>C	c.(919-921)tAt>tCt	p.Y307S	HNRNPA3_ENST00000392524.2_Missense_Mutation_p.Y329S|HNRNPA3_ENST00000435711.1_Missense_Mutation_p.Y329S	NM_194247.2	NP_919223.1	P51991	ROA3_HUMAN	heterogeneous nuclear ribonucleoprotein A3	329	Gly-rich.					catalytic step 2 spliceosome|nucleolus|nucleoplasm	nucleotide binding|protein binding|RNA binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|urinary_tract(1)	16						GGTGGGAACTATAATGATTTT	0.398000													38	79					0	0	1	0	0
DTX3	196403	broad.mit.edu	37	12	58002418	58002418	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr12:58002418G>A	ENST00000548198.1	+	4	2370	c.866G>A	c.(865-867)cGt>cAt	p.R289H	DTX3_ENST00000337737.3_Missense_Mutation_p.R289H|DTX3_ENST00000548804.1_Missense_Mutation_p.R289H|DTX3_ENST00000551632.1_Missense_Mutation_p.R292H			Q8N9I9	DTX3_HUMAN	deltex homolog 3 (Drosophila)	289					Notch signaling pathway	cytoplasm	zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(1)|lung(6)|urinary_tract(1)	12	Melanoma(17;0.122)					TTTGACCAGCGTCTCACCTTC	0.612000													5	33					0	0	1	0	0
OR52D1	390066	broad.mit.edu	37	11	5509965	5509965	+	Missense_Mutation	SNP	A	A	G			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr11:5509965A>G	ENST00000322641.5	+	1	51	c.29A>G	c.(28-30)cAt>cGt	p.H10R	AC104389.28_ENST00000415970.1_RNA|HBG2_ENST00000380259.2_Intron|HBG2_ENST00000380252.1_Intron|HBE1_ENST00000380237.1_Intron	NM_001005163.2	NP_001005163.1	Q9H346	O52D1_HUMAN	olfactory receptor, family 52, subfamily D, member 1	10					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(5)|lung(8)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	22		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.46e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGTGATAACCATCTTCCAGAC	0.458000													12	86					0	0	1	0	0
ACRC	93953	broad.mit.edu	37	X	70824046	70824046	+	Missense_Mutation	SNP	G	G	C	rs142978522		TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chrX:70824046G>C	ENST00000373695.1	+	7	1456	c.919G>C	c.(919-921)Gac>Cac	p.D307H	ACRC_ENST00000373696.3_Missense_Mutation_p.D307H			Q96QF7	ACRC_HUMAN	acidic repeat containing	307	Asp/Ser-rich.					nucleus				autonomic_ganglia(1)|breast(1)|endometrium(15)|kidney(4)|large_intestine(4)|lung(20)|ovary(5)|prostate(1)|skin(2)|stomach(1)	54	Renal(35;0.156)					AGCTCCCGACGACAAGAGTGA	0.507000													8	174					0	0	1	0	0
WASH3P	374666	broad.mit.edu	37	15	102516464	102516464	+	RNA	SNP	T	T	G			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr15:102516464T>G	ENST00000557932.1	+	0	1412																				central_nervous_system(1)|endometrium(6)|kidney(11)|prostate(5)|stomach(1)|urinary_tract(1)	25						CGACTGGGAATCCTAGGGGGC	0.642000													8	78					0	0	1	0	0
SIAE	54414	broad.mit.edu	37	11	124507096	124507096	+	Missense_Mutation	SNP	G	G	C			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr11:124507096G>C	ENST00000263593.3	-	10	1495	c.1323C>G	c.(1321-1323)atC>atG	p.I441M	SIAE_ENST00000545756.1_Missense_Mutation_p.I406M			Q9HAT2	SIAE_HUMAN	sialic acid acetylesterase	441						extracellular region|lysosome	carboxylesterase activity|sialate O-acetylesterase activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(5)|upper_aerodigestive_tract(2)	15	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.63e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0243)		TGCAACAGGAGATCTAATAAG	0.493000													17	144					0	0	1	0	0
RAB12	201475	broad.mit.edu	37	18	8638229	8638229	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr18:8638229C>T	ENST00000329286.6	+	6	987	c.704C>T	c.(703-705)cCt>cTt	p.P235L		NM_001025300.2	NP_001020471.2	Q6IQ22	RAB12_HUMAN	RAB12, member RAS oncogene family	235					protein transport|small GTPase mediated signal transduction	Golgi membrane	GTP binding			breast(1)|lung(4)|prostate(1)|urinary_tract(1)	7						CCAGAACTGCCTCCACCAAGA	0.428000													6	71					0	0	1	0	0
CNTN5	53942	broad.mit.edu	37	11	100126556	100126556	+	Silent	SNP	C	C	A			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr11:100126556C>A	ENST00000524871.1	+	17	2360	c.2070C>A	c.(2068-2070)tcC>tcA	p.S690S	CNTN5_ENST00000527185.1_Silent_p.S690S|CNTN5_ENST00000524560.1_3'UTR|CNTN5_ENST00000279463.3_Silent_p.S690S|CNTN5_ENST00000418526.2_Silent_p.S616S|CNTN5_ENST00000528682.1_Silent_p.S690S	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	690	Fibronectin type-III 1.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		CCACACTGTCCTGGAGCCCAG	0.507000													13	66					0.00136819	0.0015006	1	1	0
ANO7	50636	broad.mit.edu	37	2	242128075	242128075	+	Missense_Mutation	SNP	C	C	T			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr2:242128075C>T	ENST00000274979.8	+	1	152	c.49C>T	c.(49-51)Ccc>Tcc	p.P17S	ANO7_ENST00000402430.3_Missense_Mutation_p.P17S|ANO7_ENST00000402530.3_Missense_Mutation_p.P17S	NM_001001891.3	NP_001001891.2	Q6IWH7	ANO7_HUMAN	anoctamin 7	17						cell junction|chloride channel complex|cytosol	chloride channel activity			NS(1)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(14)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(2)	32						GCCACCCCTCCCCACCCTCTG	0.677000													3	28					0	0	1	0	0
CREBBP	1387	broad.mit.edu	37	16	3779596	3779596	+	Missense_Mutation	SNP	C	C	A			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr16:3779596C>A	ENST00000262367.5	-	31	6261	c.5452G>T	c.(5452-5454)Gtg>Ttg	p.V1818L	CREBBP_ENST00000382070.3_Missense_Mutation_p.V1780L	NM_004380.2	NP_004371.2	Q92793	CBP_HUMAN	CREB binding protein	1818	Interaction with TRERF1.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(4)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(125)|kidney(5)|large_intestine(32)|lung(43)|ovary(18)|pancreas(2)|prostate(6)|skin(9)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(21)	295		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		TGCTTGCACACCGGGCAGCCC	0.607000			"""T, N, F, Mis, O"""	"""MLL, MORF, RUNXBP2"""	"""ALL, AML, DLBCL, B-NHL """		Rubinstein-Taybi syndrome						11	109					3.86212e-05	4.528e-05	1	1	0
ZNF611	81856	broad.mit.edu	37	19	53208929	53208929	+	Missense_Mutation	SNP	T	T	A			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr19:53208929T>A	ENST00000543227.1	-	6	1653	c.1379A>T	c.(1378-1380)gAc>gTc	p.D460V	ZNF611_ENST00000453741.2_Missense_Mutation_p.D391V|ZNF611_ENST00000319783.1_Missense_Mutation_p.D460V|ZNF611_ENST00000540744.1_Missense_Mutation_p.D460V|ZNF611_ENST00000595798.1_Missense_Mutation_p.D391V|ZNF611_ENST00000602162.1_Missense_Mutation_p.D391V	NM_001161499.1	NP_001154971.1	Q8N823	ZN611_HUMAN	zinc finger protein 611	460					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|lung(12)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				OV - Ovarian serous cystadenocarcinoma(262;0.0233)|GBM - Glioblastoma multiforme(134;0.04)		AAAAGCCTTGTCACAAACCTT	0.398000													51	288					0	0	1	0	0
CUL1	8454	broad.mit.edu	37	7	148451163	148451163	+	Missense_Mutation	SNP	G	G	A			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr7:148451163G>A	ENST00000325222.4	+	3	515	c.236G>A	c.(235-237)gGa>gAa	p.G79E	CUL1_ENST00000602748.1_Missense_Mutation_p.G79E|CUL1_ENST00000409469.1_Missense_Mutation_p.G79E	NM_003592.2	NP_003583.2	Q13616	CUL1_HUMAN	cullin 1	79				Missing (in Ref. 1; AAC50544).	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein ubiquitination|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|nucleoplasm|SCF ubiquitin ligase complex	ubiquitin protein ligase binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(5)|large_intestine(10)|liver(2)|lung(10)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	40	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			CAGACACCTGGAGGAGCTCAG	0.383000													10	55					0	0	1	0	0
FNIP1	96459	broad.mit.edu	37	5	130987631	130987631	+	Missense_Mutation	SNP	C	C	A			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr5:130987631C>A	ENST00000307968.7	-	15	3085	c.3086G>T	c.(3085-3087)tGg>tTg	p.W1029L	FNIP1_ENST00000510461.1_Missense_Mutation_p.W1057L|FNIP1_ENST00000307954.8_Missense_Mutation_p.W1012L|FNIP1_ENST00000514667.1_Intron	NM_001008738.2	NP_001008738.2			folliculin interacting protein 1											NS(1)|breast(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(11)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34		all_cancers(142;0.00347)|Lung NSC(810;0.106)|all_lung(232;0.123)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0665)		TTGAACAGTCCATTTATCCAT	0.378000													10	96					3.86212e-05	4.528e-05	1	1	0
NR2F2	7026	broad.mit.edu	37	15	96875608	96875608	+	Missense_Mutation	SNP	G	G	T			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr15:96875608G>T	ENST00000394166.3	+	1	1663	c.274G>T	c.(274-276)Ggc>Tgc	p.G92C	NR2F2_ENST00000421109.2_Intron	NM_021005.3	NP_066285.1	P24468	COT2_HUMAN	nuclear receptor subfamily 2, group F, member 2	92					lipid metabolic process|negative regulation of cyclin-dependent protein kinase activity|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment	nucleus	ligand-regulated transcription factor activity|protein homodimerization activity|retinoic acid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription corepressor activity|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|liver(2)|lung(3)|ovary(2)|urinary_tract(1)	17	Lung NSC(78;0.0186)|Melanoma(26;0.0195)|all_lung(78;0.0297)		OV - Ovarian serous cystadenocarcinoma(32;0.0856)			CAAGCACTACGGCCAGTTCAC	0.652000													4	15					0.014758	0.0152052	1	1	0
ZNF423	23090	broad.mit.edu	37	16	49671871	49671871	+	Silent	SNP	G	G	T			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr16:49671871G>T	ENST00000561648.1	-	4	1245	c.1192C>A	c.(1192-1194)Cgg>Agg	p.R398R	ZNF423_ENST00000562871.1_Silent_p.R338R|ZNF423_ENST00000563137.2_Silent_p.R338R|ZNF423_ENST00000562520.1_Silent_p.R338R|ZNF423_ENST00000262383.2_Silent_p.R398R|ZNF423_ENST00000567169.1_Silent_p.R281R|ZNF423_ENST00000535559.1_Silent_p.R281R	NM_001271620.1	NP_001258549.1	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	398					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding	p.R398W(2)		breast(1)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(16)|lung(47)|ovary(1)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	89		all_cancers(37;0.0155)				CCGTCATCCCGCATCTTCTTC	0.637000													8	68					0.000157383	0.000175444	1	1	0
CRY2	1408	broad.mit.edu	37	11	45880359	45880359	+	Silent	SNP	G	G	A			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr11:45880359G>A	ENST00000443527.2	+	3	487	c.465G>A	c.(463-465)aaG>aaA	p.K155K	CRY2_ENST00000473199.1_3'UTR|CRY2_ENST00000417225.2_Silent_p.K73K	NM_021117.3	NP_066940.2	Q49AN0	CRY2_HUMAN	cryptochrome 2 (photolyase-like)	134	DNA photolyase.				DNA repair|protein-chromophore linkage|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	blue light photoreceptor activity|damaged DNA binding|DNA photolyase activity|nucleotide binding|protein binding|single-stranded DNA binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(2)	15						CCATCATGAAGATGGCCAAGG	0.512000													5	61					0	0	1	0	0
SATL1	340562	broad.mit.edu	37	X	84363320	84363320	+	Missense_Mutation	SNP	T	T	A			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chrX:84363320T>A	ENST00000509231.1	-	1	734	c.655A>T	c.(655-657)Agc>Tgc	p.S219C	SATL1_ENST00000332921.5_Missense_Mutation_p.S32C|SATL1_ENST00000395409.3_Missense_Mutation_p.S32C			Q86VE3	SATL1_HUMAN	spermidine/spermine N1-acetyl transferase-like 1	32	Gln-rich.						N-acetyltransferase activity			NS(1)|breast(5)|endometrium(2)|large_intestine(3)|lung(13)|skin(3)|stomach(1)|urinary_tract(1)	29						ACTTGCTGGCTCATGCCTGGT	0.537000													10	82					0	0	1	0	0
REG1A	5967	broad.mit.edu	37	2	79350329	79350329	+	Silent	SNP	G	G	A			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr2:79350329G>A	ENST00000233735.1	+	6	592	c.489G>A	c.(487-489)aaG>aaA	p.K163K		NM_002909.4	NP_002900.2	P05451	REG1A_HUMAN	regenerating islet-derived 1 alpha	163	C-type lectin.				positive regulation of cell proliferation	extracellular region	growth factor activity|sugar binding			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(26)|prostate(1)|upper_aerodigestive_tract(1)	39						TTGTCTGCAAGTTCAAAAACT	0.413000													5	73					0	0	1	0	0
RREB1	6239	broad.mit.edu	37	6	7230237	7230237	+	Silent	SNP	G	G	A			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr6:7230237G>A	ENST00000379938.2	+	10	2442	c.1905G>A	c.(1903-1905)acG>acA	p.T635T	RREB1_ENST00000349384.6_Silent_p.T635T|RREB1_ENST00000379933.3_Silent_p.T635T|RREB1_ENST00000334984.6_Silent_p.T635T	NM_001003699.3|NM_001003700.1	NP_001003699.1|NP_001003700.1	Q92766	RREB1_HUMAN	ras responsive element binding protein 1	635					multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|lung(18)|ovary(5)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				GCAAGAAGACGCCCGCCATGC	0.642000													6	31					0	0	1	0	0
COL1A2	1278	broad.mit.edu	37	7	94038707	94038707	+	Missense_Mutation	SNP	G	G	T	rs67031201		TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr7:94038707G>T	ENST00000297268.6	+	17	1337	c.866G>T	c.(865-867)gGc>gTc	p.G289V		NM_000089.3	NP_000080.2	P08123	CO1A2_HUMAN	collagen, type I, alpha 2	289					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	NS(2)|breast(2)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(21)|lung(51)|ovary(2)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	115	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	GGTCTTCCAGGCCTCTCCGGC	0.488000										HNSCC(75;0.22)			10	90					1.49906e-05	1.78835e-05	1	1	0
TTN	7273	broad.mit.edu	37	2	179664617	179664617	+	Missense_Mutation	SNP	T	T	C			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr2:179664617T>C	ENST00000589042.1	-	5	828	c.604A>G	c.(604-606)Aaa>Gaa	p.K202E	TTN_ENST00000342992.6_Missense_Mutation_p.K202E|TTN_ENST00000460472.2_Missense_Mutation_p.K202E|TTN_ENST00000591111.1_Missense_Mutation_p.K202E|TTN_ENST00000342175.6_Missense_Mutation_p.K202E|TTN_ENST00000360870.5_Missense_Mutation_p.K202E|TTN_ENST00000359218.5_Missense_Mutation_p.K202E	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	202							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTGTCTTTTTAGCAGGTACT	0.383000													4	100					0	0	1	0	0
GP2	2813	broad.mit.edu	37	16	20327363	20327363	+	Splice_Site	SNP	C	C	A			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr16:20327363C>A	ENST00000302555.5	-	9	1566		c.e9-1		GP2_ENST00000341642.5_Splice_Site|GP2_ENST00000381360.5_Splice_Site|GP2_ENST00000381362.4_Splice_Site			P55259	GP2_HUMAN	glycoprotein 2 (zymogen granule membrane)							anchored to membrane|extracellular region|plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						TTGAGCAAGACTGTAGGGATG	0.478000													6	80					1.26484e-09	1.63828e-09	1	1	0
ANKRD36BP2	645784	broad.mit.edu	37	2	89083945	89083946	+	RNA	INS	-	-	GC			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr2:89083945_89083946insGC	ENST00000393525.3	+	0	576																											GTATTCCTTTTTTTTCAGTGTA	0.347													3	4	---	---	---	---					
FAT1	2195	broad.mit.edu	37	4	187542175	187542196	+	Frame_Shift_Del	DEL	TGGGGTTCCCATGTCATGCACT	TGGGGTTCCCATGTCATGCACT	-			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr4:187542175_187542196delTGGGGTTCCCATGTCATGCACT	ENST00000441802.2	-	10	5753_5774	c.5544_5565delAGTGCATGACATGGGAACCCCA	c.(5542-5565)cafs	p.QVHDMGTP1848fs		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	1848	Cadherin 16.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						CAAATAAACGTGGGGTTCCCATGTCATGCACTTGGACGGTAA	0.396										HNSCC(5;0.00058)			9	58	---	---	---	---					
BDP1	55814	broad.mit.edu	37	5	70761984	70761984	+	Frame_Shift_Del	DEL	G	G	-			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr5:70761984delG	ENST00000358731.4	+	5	984	c.721delG	c.(721-723)ggfs	p.G241fs	BDP1_ENST00000380675.2_5'UTR	NM_018429.2	NP_060899.2	A6H8Y1	BDP1_HUMAN	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB	241	Interaction with ZBTB43.				regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			NS(2)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(34)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	72		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		GACAGATGATGGGCCATTACT	0.368													8	135	---	---	---	---					
C6orf165	154313	broad.mit.edu	37	6	88144700	88144700	+	Frame_Shift_Del	DEL	A	A	-			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr6:88144700delA	ENST00000507897.1	+	11	1506	c.1423delA	c.(1423-1425)aafs	p.K476fs	C6ORF165_ENST00000369562.4_Frame_Shift_Del_p.K476fs			Q8IYR0	CF165_HUMAN	chromosome 6 open reading frame 165	476										NS(1)|central_nervous_system(1)|large_intestine(5)|lung(8)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0419)		AGAAAAGGCCAAAAAAAATAC	0.269													7	157	---	---	---	---					
TMEM184A	202915	broad.mit.edu	37	7	1586653	1586654	+	In_Frame_Ins	INS	-	-	GCC	rs112463195	by1000genomes	TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr7:1586653_1586654insGCC	ENST00000297477.5	-	9	1492_1493	c.1176_1177insGGC	c.(1174-1179)ggccgg>ggGGCccgg	p.392_393GR>GAR		NM_001097620.1	NP_001091089.1	Q6ZMB5	T184A_HUMAN	transmembrane protein 184A	392						integral to membrane				endometrium(1)|large_intestine(1)|lung(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	12		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;5.88e-15)		CTCCCGCCGGAGCCGCCGCTGG	0.708													8	6	---	---	---	---					
ACTN3	89	broad.mit.edu	37	11	66324669	66324669	+	RNA	DEL	G	G	-			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr11:66324669delG	ENST00000513398.1	+	0	967				ACTN3_ENST00000502692.1_RNA	NM_001104.2	NP_001095.1	Q08043	ACTN3_HUMAN	actinin, alpha 3 (gene/pseudogene)						focal adhesion assembly|muscle filament sliding|regulation of apoptosis	actin filament|cytosol|focal adhesion|pseudopodium	actin binding|calcium ion binding|integrin binding|protein homodimerization activity|structural constituent of muscle			breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(2)	10						AGAAGCTGATGGAGGAGTATG	0.602													2	4	---	---	---	---					
TRAV24	28659	broad.mit.edu	37	14	22573825	22573826	+	RNA	INS	-	-	A	rs33991650	by1000genomes	TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr14:22573825_22573826insA	ENST00000390453.1	+	0	55																											GACTCTTTTTTAAAAAAACAGG	0.450													5	8	---	---	---	---					
ADAMTS7	11173	broad.mit.edu	37	15	79056182	79056182	+	Frame_Shift_Del	DEL	G	G	-			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr15:79056182delG	ENST00000388820.4	-	22	4809	c.4599delC	c.(4597-4599)tcfs	p.S1533fs		NM_014272.3	NP_055087.2	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 7	1533	TSP type-1 7.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(23)|ovary(1)|prostate(8)|skin(9)	54						CACAGGCCTCGGAGCACTGGG	0.687													2	4	---	---	---	---					
TP53	7157	broad.mit.edu	37	17	7579470	7579471	+	Frame_Shift_Ins	INS	-	-	G	rs56275308		TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr17:7579470_7579471insG	ENST00000420246.2	-	4	348_349	c.216_217insC	c.(214-219)cctggcfs	p.G73fs	TP53_ENST00000269305.4_Frame_Shift_Ins_p.G73fs|TP53_ENST00000413465.2_Frame_Shift_Ins_p.G73fs|TP53_ENST00000359597.4_Frame_Shift_Ins_p.G73fs|TP53_ENST00000445888.2_Frame_Shift_Ins_p.G73fs|TP53_ENST00000455263.2_Frame_Shift_Ins_p.G73fs	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	73	Interaction with HRMT1L2.|Interaction with WWOX.		V -> E (in a sporadic cancer; somatic mutation).|V -> L (in sporadic cancers; somatic mutation).|V -> M (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.V73fs*76(11)|p.0?(8)|p.V73L(3)|p.G59fs*23(3)|p.R72fs*51(2)|p.V73M(2)|p.V73fs*9(1)|p.R65fs*38(1)|p.E68fs*76(1)|p.V73fs*50(1)|p.D48fs*55(1)|p.P13fs*18(1)|p.S33fs*23(1)|p.D57_A76del20(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCAGGGGCCACGGGGGGAGCAG	0.604		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			42	180	---	---	---	---					
CTD-2245F17.3	0	broad.mit.edu	37	19	53703995	53703995	+	RNA	DEL	T	T	-	rs113703393		TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr19:53703995delT	ENST00000597550.1	+	0	232																											TGTTTCCCCCttttttttttt	0.473													5	7	---	---	---	---					
ZNF761	388561	broad.mit.edu	37	19	53946133	53946133	+	RNA	DEL	A	A	-	rs35108555		TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr19:53946133delA	ENST00000454407.1	+	0	55				TPM3P9_ENST00000424846.3_RNA			Q86XN6	ZN761_HUMAN	zinc finger protein 761						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	30				GBM - Glioblastoma multiforme(134;0.00786)		TCATGTTGTGAAAAAAAAAAT	0.348													2	4	---	---	---	---					
MYH9	4627	broad.mit.edu	37	22	36688050	36688050	+	Frame_Shift_Del	DEL	C	C	-			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chr22:36688050delC	ENST00000216181.5	-	31	4556	c.4326delG	c.(4324-4326)aafs	p.K1442fs		NM_002473.4	NP_002464.1	P35579	MYH9_HUMAN	myosin, heavy chain 9, non-muscle	1442					actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			NS(1)|breast(8)|central_nervous_system(3)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(16)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(3)	86						ACTTCTTCTGCTTCTTCTCCA	0.582			T	ALK	ALCL		"""Deafness, autosomal dominant 17, Epstein syndrome, Fechtner syndrome, May-Hegglin anomaly, Sebastian syndrome"""		Hereditary Macrothrombocytopenia, MYH9-associated				14	66	---	---	---	---					
IRS4	8471	broad.mit.edu	37	X	107977802	107977803	+	Frame_Shift_Ins	INS	-	-	C			TCGA-UF-A7JJ-01A-11D-A34J-08	TCGA-UF-A7JJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2136826-7308-4afb-a7ab-8253e2c9797f	1a38a188-915a-46cf-9ef6-a66354ff19f6	g.chrX:107977802_107977803insC	ENST00000372129.2	-	1	1848_1849	c.1772_1773insG	c.(1771-1773)gaafs	p.E591fs		NM_003604.2	NP_003595.1	O14654	IRS4_HUMAN	insulin receptor substrate 4	591						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			NS(1)|breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(1)	78						CTGAGCCTTTGCCCCCCCCAGA	0.545													7	221	---	---	---	---