Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MAP2	4133	broad.mit.edu	37	2	210588337	210588337	+	Nonsense_Mutation	SNP	A	A	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr2:210588337A>T	ENST00000199940.6	+	12	1635	c.1195A>T	c.(1195-1197)Aag>Tag	p.K399*	MAP2_ENST00000392194.1_Intron|MAP2_ENST00000475600.1_3'UTR|MAP2_ENST00000360351.4_Intron|MAP2_ENST00000447185.1_Intron|MAP2_ENST00000361559.4_Intron	NM_001039538.1	NP_001034627.1	P11137	MAP2_HUMAN	microtubule-associated protein 2	1674					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(36)|liver(2)|lung(42)|ovary(11)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	124		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	TTTAAACAAGAAGATCGATTT	0.403000													7	51					0	0	1	0	0
ABCA1	19	broad.mit.edu	37	9	107576453	107576453	+	Missense_Mutation	SNP	G	G	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr9:107576453G>A	ENST00000374736.3	-	27	4241	c.3847C>T	c.(3847-3849)Cgc>Tgc	p.R1283C		NM_005502.3	NP_005493.2	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 1	1283					Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(31)|liver(1)|lung(40)|ovary(5)|pancreas(2)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	115				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	GTGAACGGGCGAAGACAGCTC	0.463000													16	79					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113208209	113208209	+	Missense_Mutation	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr9:113208209C>T	ENST00000401783.2	-	26	4707	c.4371G>A	c.(4369-4371)atG>atA	p.M1457I	SVEP1_ENST00000374469.1_Missense_Mutation_p.M1434I|SVEP1_ENST00000467821.1_5'UTR|SVEP1_ENST00000302728.8_Missense_Mutation_p.M1457I	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	1457	Pentaxin.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						CAGAGGATTTCATCCAGAAGG	0.453000													14	102					0	0	1	0	0
ITGAM	3684	broad.mit.edu	37	16	31282333	31282333	+	Silent	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr16:31282333C>T	ENST00000544665.3	+	6	557	c.486C>T	c.(484-486)atC>atT	p.I162I	ITGAM_ENST00000287497.8_Silent_p.I162I	NM_000632.3|NM_001145808.1	NP_000623.2|NP_001139280.1	P11215	ITAM_HUMAN	integrin, alpha M (complement component 3 receptor 3 subunit)	162	VWFA.				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(1)|prostate(4)|skin(1)	56						GTAGCATCATCCCACATGACT	0.468000													30	189					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140994837	140994837	+	Silent	SNP	T	T	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chrX:140994837T>A	ENST00000285879.4	+	4	1933	c.1647T>A	c.(1645-1647)ccT>ccA	p.P549P	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	549							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					ACTACTTTCCTCAGAGCCCTC	0.552000										HNSCC(15;0.026)			45	346					0	0	1	0	0
NELFE	7936	broad.mit.edu	37	6	31922132	31922132	+	Missense_Mutation	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr6:31922132C>T	ENST00000375429.3	-	8	1056	c.830G>A	c.(829-831)cGt>cAt	p.R277H	NELFE_ENST00000375425.5_Missense_Mutation_p.R284H|NELFE_ENST00000444811.2_Missense_Mutation_p.R247H	NM_002904.5	NP_002895.3			negative elongation factor complex member E																		GAAGGCCCCACGGAGAAGGGT	0.512000													12	96					0	0	1	0	0
MUSK	4593	broad.mit.edu	37	9	113562624	113562624	+	Missense_Mutation	SNP	G	G	C			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr9:113562624G>C	ENST00000416899.2	+	13	2068	c.1942G>C	c.(1942-1944)Gaa>Caa	p.E648Q	MUSK_ENST00000189978.5_Missense_Mutation_p.E656Q|MUSK_ENST00000374448.4_Missense_Mutation_p.E656Q			O15146	MUSK_HUMAN	muscle, skeletal, receptor tyrosine kinase	656	Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|lung(23)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	49						CCTGCTCTTTGAATACATGGC	0.507000													5	213					0	0	1	0	0
AKAP4	8852	broad.mit.edu	37	X	49957067	49957067	+	Missense_Mutation	SNP	G	G	C			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chrX:49957067G>C	ENST00000376056.2	-	5	2420	c.2270C>G	c.(2269-2271)tCt>tGt	p.S757C	AKAP4_ENST00000376058.2_Missense_Mutation_p.S383C|AKAP4_ENST00000358526.2_Missense_Mutation_p.S766C|AKAP4_ENST00000376064.3_Missense_Mutation_p.S757C|AKAP4_ENST00000481402.1_5'UTR			Q5JQC9	AKAP4_HUMAN	A kinase (PRKA) anchor protein 4	766					cell projection organization|single fertilization|sperm motility	cAMP-dependent protein kinase complex|cilium|cytoskeleton|microtubule-based flagellum	protein kinase A binding			NS(2)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(6)|lung(14)|ovary(1)|skin(4)	41	Ovarian(276;0.236)					GCTATTTGTAGAGCACTGATT	0.478000													5	24					0	0	1	0	0
CCT5	22948	broad.mit.edu	37	5	10250483	10250483	+	Missense_Mutation	SNP	G	G	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr5:10250483G>A	ENST00000280326.4	+	1	451	c.31G>A	c.(31-33)Gaa>Aaa	p.E11K	CCT5_ENST00000515390.1_Missense_Mutation_p.E11K|CCT5_ENST00000503026.1_Intron	NM_012073.3	NP_036205.1	P48643	TCPE_HUMAN	chaperonin containing TCP1, subunit 5 (epsilon)	11					'de novo' posttranslational protein folding|response to virus	microtubule organizing center|nucleolus	ATP binding|unfolded protein binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(2)	26						CGCCTTCGATGAATATGGGCG	0.587000													10	67					0	0	1	0	0
GALC	2581	broad.mit.edu	37	14	88429779	88429779	+	Silent	SNP	G	G	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr14:88429779G>A	ENST00000261304.2	-	10	1216	c.1110C>T	c.(1108-1110)taC>taT	p.Y370Y	GALC_ENST00000393568.4_Silent_p.Y347Y|GALC_ENST00000393569.2_Silent_p.Y344Y|GALC_ENST00000544807.2_Silent_p.Y314Y	NM_000153.3|NM_001201401.1	NP_000144.2|NP_001188330.1	P54803	GALC_HUMAN	galactosylceramidase	370					carbohydrate metabolic process|galactosylceramide catabolic process	lysosome	cation binding|galactosylceramidase activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						TCAGAGCTACGTAGCTTCCTC	0.403000													32	61					0	0	1	0	0
WWP2	11060	broad.mit.edu	37	16	69833085	69833085	+	Missense_Mutation	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr16:69833085C>T	ENST00000359154.2	+	4	328	c.227C>T	c.(226-228)aCg>aTg	p.T76M	WWP2_ENST00000448661.1_Missense_Mutation_p.T76M|WWP2_ENST00000356003.2_Missense_Mutation_p.T76M|WWP2_ENST00000569174.1_Missense_Mutation_p.T76M|WWP2_ENST00000544162.1_3'UTR	NM_001270454.1|NM_007014.4	NP_001257383.1|NP_008945.2	O00308	WWP2_HUMAN	WW domain containing E3 ubiquitin protein ligase 2	76	C2.				entry of virus into host cell|negative regulation of protein transport|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transporter activity|proteasomal ubiquitin-dependent protein catabolic process|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex	RNA polymerase II transcription factor binding|ubiquitin-protein ligase activity			breast(4)|endometrium(2)|kidney(2)|large_intestine(11)|lung(13)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						AGGAATGTCACGGCACAGAGT	0.408000											OREG0023909	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	101					0	0	1	0	0
SLC10A5	347051	broad.mit.edu	37	8	82606749	82606749	+	Missense_Mutation	SNP	C	C	G			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr8:82606749C>G	ENST00000518568.1	-	1	1660	c.459G>C	c.(457-459)ttG>ttC	p.L153F		NM_001010893.2	NP_001010893.1	Q5PT55	NTCP5_HUMAN	solute carrier family 10, member 5	153						integral to membrane	bile acid:sodium symporter activity			autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(5)	15						CACACTTATTCAATAGTATTA	0.353000													36	132					0	0	1	0	0
DPY19L1	23333	broad.mit.edu	37	7	35009117	35009117	+	Silent	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr7:35009117C>T	ENST00000310974.4	-	9	867	c.723G>A	c.(721-723)ttG>ttA	p.L241L	DPY19L1_ENST00000462134.2_5'UTR	NM_015283.1	NP_056098.1	Q2PZI1	D19L1_HUMAN	dpy-19-like 1 (C. elegans)	241						integral to membrane				endometrium(3)|kidney(5)|large_intestine(8)|lung(8)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(4)	31						AGAGTGCAATCAAGCTTCCTC	0.353000													16	46					0	0	1	0	0
HERC2P4	100289574	broad.mit.edu	37	16	32163490	32163490	+	RNA	SNP	A	A	G			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr16:32163490A>G	ENST00000564145.1	-	0	65																											AGAGAACTGCACGGTGATTTT	0.527000													16	121					0	0	1	0	0
OR52I2	143502	broad.mit.edu	37	11	4609034	4609034	+	Missense_Mutation	SNP	G	G	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr11:4609034G>A	ENST00000312614.4	+	1	1014	c.992G>A	c.(991-993)cGg>cAg	p.R331Q		NM_001005170.2	NP_001005170.1	Q8NH67	O52I2_HUMAN	olfactory receptor, family 52, subfamily I, member 2	331					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R331L(1)		endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|pancreas(1)|skin(1)	19		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		AAACAACTGCGGGAGAGAATA	0.473000													32	175					0	0	1	0	0
CACNG4	27092	broad.mit.edu	37	17	65026756	65026756	+	Missense_Mutation	SNP	T	T	C			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr17:65026756T>C	ENST00000262138.3	+	4	622	c.620T>C	c.(619-621)aTt>aCt	p.I207T		NM_014405.3	NP_055220.1	Q9UBN1	CCG4_HUMAN	calcium channel, voltage-dependent, gamma subunit 4	207					membrane depolarization|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane	voltage-gated calcium channel activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(3)	19	all_cancers(12;9.86e-11)		BRCA - Breast invasive adenocarcinoma(6;1.35e-07)			AACATTTACATTGAGAAAAAT	0.458000													45	103					0	0	1	0	0
DUOXA2	405753	broad.mit.edu	37	15	45410062	45410062	+	Silent	SNP	G	G	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr15:45410062G>A	ENST00000323030.5	+	6	1203	c.918G>A	c.(916-918)aaG>aaA	p.K306K	DUOXA1_ENST00000558996.1_3'UTR|DUOXA1_ENST00000559014.1_Intron|DUOXA1_ENST00000430224.2_Intron|DUOXA1_ENST00000267803.4_Intron	NM_207581.3	NP_997464.2	Q1HG44	DOXA2_HUMAN	dual oxidase maturation factor 2	306					protein transport	endoplasmic reticulum membrane|integral to membrane							all_cancers(109;5.7e-11)|all_epithelial(112;4.65e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;2.88e-18)|GBM - Glioblastoma multiforme(94;3.95e-07)|COAD - Colon adenocarcinoma(120;0.0652)|Colorectal(133;0.0659)		CACTGCACAAGCAGGCCGCTC	0.612000											OREG0023102	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	83					0	0	1	0	0
POC1A	25886	broad.mit.edu	37	3	52183327	52183327	+	Silent	SNP	G	G	A	rs150866318	byFrequency	TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr3:52183327G>A	ENST00000394970.2	-	4	671	c.354C>T	c.(352-354)ttC>ttT	p.F118F	POC1A_ENST00000296484.2_Silent_p.F118F|POC1A_ENST00000474012.1_Silent_p.F80F	NM_001161580.1	NP_001155052.1	Q8NBT0	POC1A_HUMAN	POC1 centriolar protein A	118						centriole|microtubule basal body				endometrium(1)|large_intestine(4)|liver(1)|lung(4)|prostate(3)|skin(1)	14						AGGCTGTCACGAAGGACTGGC	0.537000													33	68					0	0	1	0	0
PTER	9317	broad.mit.edu	37	10	16526539	16526539	+	Silent	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr10:16526539C>T	ENST00000378000.1	+	3	402	c.156C>T	c.(154-156)atC>atT	p.I52I	PTER_ENST00000423462.2_Silent_p.I52I|PTER_ENST00000298942.3_Silent_p.I52I|PTER_ENST00000535784.2_Silent_p.I52I	NM_001001484.2|NM_001261838.1|NM_030664.4	NP_001001484.1|NP_001248767.1|NP_109589.2	Q96BW5	PTER_HUMAN	phosphotriesterase related	52					catabolic process		hydrolase activity, acting on ester bonds|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(7)|lung(4)|ovary(2)	15						AAGAACCTATCGTGATGAAAA	0.438000													7	94					0	0	1	0	0
SETX	23064	broad.mit.edu	37	9	135173682	135173682	+	Nonsense_Mutation	SNP	C	C	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr9:135173682C>A	ENST00000372169.2	-	13	5748	c.5566G>T	c.(5566-5568)Gag>Tag	p.E1856*	SETX_ENST00000224140.5_Nonsense_Mutation_p.E1856*|SETX_ENST00000393220.1_Nonsense_Mutation_p.E1856*			Q7Z333	SETX_HUMAN	senataxin	1856					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(1)|lung(36)|ovary(2)|prostate(2)|skin(1)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	97		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		AGGTAACACTCAGTTTTCCCA	0.373000													59	88					6.83704e-37	7.71118e-37	1	1	0
ISCA1	81689	broad.mit.edu	37	9	88881057	88881057	+	Silent	SNP	T	T	C			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr9:88881057T>C	ENST00000375991.4	-	4	361	c.291A>G	c.(289-291)acA>acG	p.T97T	ISCA1_ENST00000311534.6_5'UTR|ISCA1_ENST00000452279.2_Silent_p.T144T	NM_030940.3	NP_112202.2	Q9BUE6	ISCA1_HUMAN	iron-sulfur cluster assembly 1	97					iron-sulfur cluster assembly	mitochondrion	iron-sulfur cluster binding|metal ion binding|structural molecule activity			endometrium(2)|large_intestine(1)|lung(4)|pancreas(1)	8				OV - Ovarian serous cystadenocarcinoma(323;5.4e-34)|Lung(182;0.0375)		AGTCCATTTCTGTTCCTAAAA	0.383000													28	244					0	0	1	0	0
LOC101927905	101927905	broad.mit.edu	37	12	8391292	8391292	+	RNA	SNP	G	G	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr12:8391292G>A	ENST00000304751.9	+	0	585				FAM86FP_ENST00000427893.2_RNA																							AGAAAGCACCGGGCATACTTG	0.562000													5	78					0	0	1	0	0
ZKSCAN7	55888	broad.mit.edu	37	3	44609924	44609924	+	Splice_Site	SNP	G	G	C			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr3:44609924G>C	ENST00000273320.3	+	5	1239	c.811_splice	c.e5+1	p.L270_splice	ZKSCAN7_ENST00000341840.3_Splice_Site_p.L270_splice|RP11-944L7.4_ENST00000457331.1_RNA|ZKSCAN7_ENST00000426540.1_Splice_Site_p.L270_splice|ZKSCAN7_ENST00000431636.1_Splice_Site_p.L270_splice	NM_018651.2	NP_061121.2			zinc finger with KRAB and SCAN domains 7																		TGGCCTCCTTGGGTAATGATT	0.403000													18	50					0	0	1	0	0
FAM186B	84070	broad.mit.edu	37	12	49994396	49994396	+	Missense_Mutation	SNP	C	C	G			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr12:49994396C>G	ENST00000544141.1	-	4	1356	c.757G>C	c.(757-759)Gag>Cag	p.E253Q	PRPF40B_ENST00000508736.1_3'UTR|FAM186B_ENST00000551047.1_Intron|FAM186B_ENST00000257894.2_Missense_Mutation_p.E343Q			Q8IYM0	F186B_HUMAN	family with sequence similarity 186, member B	343						protein complex				breast(1)|endometrium(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						GTCTCTCTCTCAGAGGGACCT	0.542000													22	191					0	0	1	0	0
DHRS9	10170	broad.mit.edu	37	2	169938254	169938254	+	Missense_Mutation	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr2:169938254C>T	ENST00000327239.4	+	5	1667	c.163C>T	c.(163-165)Cat>Tat	p.H55Y	DHRS9_ENST00000421653.1_5'UTR|DHRS9_ENST00000412271.1_Missense_Mutation_p.H55Y|DHRS9_ENST00000357546.2_Missense_Mutation_p.H55Y|DHRS9_ENST00000428522.1_Missense_Mutation_p.H55Y|DHRS9_ENST00000436483.2_Missense_Mutation_p.H55Y|DHRS9_ENST00000602501.1_Missense_Mutation_p.H55Y|DHRS9_ENST00000432060.2_Missense_Mutation_p.H115Y	NM_005771.4	NP_005762.2	Q9BPW9	DHRS9_HUMAN	dehydrogenase/reductase (SDR family) member 9	55					9-cis-retinoic acid biosynthetic process|androgen metabolic process|epithelial cell differentiation|progesterone metabolic process|retinol metabolic process	integral to endoplasmic reticulum membrane|microsome	alcohol dehydrogenase (NAD) activity|binding|racemase and epimerase activity|retinol dehydrogenase activity|testosterone dehydrogenase (NAD+) activity			breast(1)|endometrium(3)|large_intestine(2)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	13						AAAGGGATTTCATGTAATCGC	0.428000													5	91					0	0	1	0	0
LRTM1	57408	broad.mit.edu	37	3	54952906	54952906	+	Missense_Mutation	SNP	G	G	C			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr3:54952906G>C	ENST00000273286.5	-	3	780	c.618C>G	c.(616-618)gaC>gaG	p.D206E	LRTM1_ENST00000493075.1_Missense_Mutation_p.D130E|CACNA2D3_ENST00000415676.2_Intron|CACNA2D3_ENST00000288197.5_Intron|CACNA2D3_ENST00000490478.1_Intron|CACNA2D3_ENST00000474759.1_Intron	NM_020678.2	NP_065729.1	Q9HBL6	LRTM1_HUMAN	leucine-rich repeats and transmembrane domains 1	206	LRRCT.					integral to membrane				breast(1)|endometrium(2)|large_intestine(7)|lung(6)|prostate(1)|skin(4)	21				KIRC - Kidney renal clear cell carcinoma(284;0.00975)|Kidney(284;0.0112)|OV - Ovarian serous cystadenocarcinoma(275;0.0502)		AGATGATGCCGTCTGTTAGTC	0.473000													15	27					0	0	1	0	0
DNLZ	728489	broad.mit.edu	37	9	139256512	139256512	+	Missense_Mutation	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr9:139256512C>T	ENST00000371739.3	-	2	353	c.349G>A	c.(349-351)Ggg>Agg	p.G117R	DNLZ_ENST00000371738.3_Silent_p.A163A			Q5SXM8	DNLZ_HUMAN	DNL-type zinc finger	0							metal ion binding			central_nervous_system(1)|prostate(1)	2		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.42e-06)|Epithelial(140;3.3e-06)		CATCCTCACCCGCTTCCGGAG	0.692000													3	21					0	0	1	0	0
PLEKHS1	79949	broad.mit.edu	37	10	115536953	115536953	+	Missense_Mutation	SNP	A	A	G			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr10:115536953A>G	ENST00000354462.3	+	5	510	c.352A>G	c.(352-354)Aat>Gat	p.N118D	PLEKHS1_ENST00000369312.4_Missense_Mutation_p.N286D|PLEKHS1_ENST00000369309.1_Missense_Mutation_p.N202D|PLEKHS1_ENST00000369310.3_Missense_Mutation_p.N368D|PLEKHS1_ENST00000361048.1_Intron					pleckstrin homology domain containing, family S member 1																		TCTGGCAGTGAATGACCTGAA	0.537000													6	34					0	0	1	0	0
GRIP2	80852	broad.mit.edu	37	3	14564568	14564568	+	RNA	SNP	C	C	G			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr3:14564568C>G	ENST00000273083.3	-	0	570							Q9C0E4	GRIP2_HUMAN	glutamate receptor interacting protein 2						synaptic transmission	cytosol|plasma membrane	protein binding			endometrium(5)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	25						TTGTGCCCATCTTCATGGGCA	0.617000													11	86					0	0	1	0	0
MYH10	4628	broad.mit.edu	37	17	8526300	8526300	+	Missense_Mutation	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr17:8526300C>T	ENST00000360416.3	-	2	403	c.265G>A	c.(265-267)Gat>Aat	p.D89N	MYH10_ENST00000396239.1_Missense_Mutation_p.D89N|MYH10_ENST00000269243.4_Missense_Mutation_p.D89N|MYH10_ENST00000379980.4_Missense_Mutation_p.D89N	NM_001256012.1	NP_001242941.1	P35580	MYH10_HUMAN	myosin, heavy chain 10, non-muscle	89	Myosin head-like.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			breast(5)|endometrium(9)|kidney(2)|large_intestine(16)|lung(9)|ovary(3)|prostate(3)|skin(4)|stomach(1)	52						TCTGCCATATCCTCCACCTTG	0.378000													43	158					0	0	1	0	0
ITIH6	347365	broad.mit.edu	37	X	54817504	54817504	+	Missense_Mutation	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chrX:54817504C>T	ENST00000218436.6	-	4	411	c.382G>A	c.(382-384)Gag>Aag	p.E128K		NM_198510.2	NP_940912.1	Q6UXX5	ITH5L_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 6	128	VIT.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity										CGGAACTTCTCTGATTCCCGG	0.582000													3	32					0	0	1	0	0
ATP2B4	493	broad.mit.edu	37	1	203668809	203668809	+	Missense_Mutation	SNP	G	G	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr1:203668809G>A	ENST00000357681.5	+	4	1736	c.613G>A	c.(613-615)Gag>Aag	p.E205K	ATP2B4_ENST00000367218.3_Missense_Mutation_p.E205K|ATP2B4_ENST00000391954.2_Missense_Mutation_p.E205K|ATP2B4_ENST00000341360.2_Missense_Mutation_p.E205K|ATP2B4_ENST00000367219.3_Missense_Mutation_p.E205K	NM_001684.4	NP_001675.3	P23634	AT2B4_HUMAN	ATPase, Ca++ transporting, plasma membrane 4	205					ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(10)|lung(20)|ovary(2)|prostate(6)|skin(1)|stomach(1)|urinary_tract(3)	56	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			CCCTGTGGCTGAGATTGTGGT	0.512000													87	159					0	0	1	0	0
DOCK8	81704	broad.mit.edu	37	9	368169	368169	+	Missense_Mutation	SNP	G	G	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr9:368169G>A	ENST00000382329.1	+	2	454	c.67G>A	c.(67-69)Ggg>Agg	p.G23R	DOCK8_ENST00000432829.2_Intron|DOCK8_ENST00000469391.1_Intron|DOCK8_ENST00000453981.1_Intron|DOCK8_ENST00000382331.1_Intron			Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	0					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(5)|endometrium(2)|kidney(6)|large_intestine(13)|lung(22)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	65		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		CCTCAAATCAGGGTGGGCTGC	0.498000													18	89					0	0	1	0	0
FBXO4	26272	broad.mit.edu	37	5	41927222	41927222	+	Missense_Mutation	SNP	G	G	C			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr5:41927222G>C	ENST00000296812.2	+	2	353	c.297G>C	c.(295-297)tgG>tgC	p.W99C	FBXO4_ENST00000281623.3_Missense_Mutation_p.W99C|FBXO4_ENST00000509134.1_Missense_Mutation_p.W99C	NM_033484.2	NP_277019.1	Q9UKT5	FBX4_HUMAN	F-box protein 4	99	F-box.				positive regulation of protein ubiquitination|protein polyubiquitination|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|telomere maintenance|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	protein binding|protein homodimerization activity|ubiquitin-protein ligase activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(6)|liver(1)|lung(11)|prostate(1)|stomach(1)|urinary_tract(2)	27		Lung NSC(810;4.15e-05)|Breast(839;0.00093)|Ovarian(839;0.00965)|Myeloproliferative disorder(839;0.0255)|all_neural(839;0.0604)				CAATTCTGTGGAGATACTTTT	0.373000													26	102					0	0	1	0	0
CREBBP	1387	broad.mit.edu	37	16	3779447	3779447	+	Silent	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr16:3779447C>T	ENST00000262367.5	-	31	6410	c.5601G>A	c.(5599-5601)cgG>cgA	p.R1867R	CREBBP_ENST00000382070.3_Silent_p.R1829R	NM_004380.2	NP_004371.2	Q92793	CBP_HUMAN	CREB binding protein	1867	Interaction with TRERF1.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(4)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(125)|kidney(5)|large_intestine(32)|lung(43)|ovary(18)|pancreas(2)|prostate(6)|skin(9)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(21)	295		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		TGGCCATCCGCCGGCGCATGA	0.637000			"""T, N, F, Mis, O"""	"""MLL, MORF, RUNXBP2"""	"""ALL, AML, DLBCL, B-NHL """		Rubinstein-Taybi syndrome						13	71					0	0	1	0	0
MME	4311	broad.mit.edu	37	3	154834708	154834708	+	Missense_Mutation	SNP	G	G	C			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr3:154834708G>C	ENST00000460393.1	+	7	707	c.587G>C	c.(586-588)gGg>gCg	p.G196A	MME_ENST00000360490.2_Missense_Mutation_p.G196A|MME_ENST00000493237.1_Missense_Mutation_p.G196A|MME_ENST00000492661.1_Missense_Mutation_p.G196A|MME_ENST00000462745.1_Missense_Mutation_p.G196A	NM_000902.3|NM_007287.2	NP_000893.2|NP_009218.2	P08473	NEP_HUMAN	membrane metallo-endopeptidase	196					cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(31)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	TCTAAATATGGGAAAAAAGTC	0.299000													15	87					0	0	1	0	0
HBM	3042	broad.mit.edu	37	16	216068	216068	+	Silent	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr16:216068C>T	ENST00000356815.3	+	1	92	c.72C>T	c.(70-72)ttC>ttT	p.F24F	HBM_ENST00000472539.1_Intron	NM_001003938.3	NP_001003938.1	Q6B0K9	HBM_HUMAN	hemoglobin, mu	24						hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity						all_cancers(16;1.62e-06)|all_epithelial(16;4.01e-06)|Hepatocellular(16;0.000325)|Lung NSC(18;0.0104)|all_lung(18;0.0239)				AGGCGCAATTCGGGGCGGAGC	0.701000													9	13					0	0	1	0	0
PPY	5539	broad.mit.edu	37	17	42019013	42019013	+	Missense_Mutation	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr17:42019013C>T	ENST00000591228.1	-	2	97	c.10G>A	c.(10-12)Gca>Aca	p.A4T	PPY_ENST00000225992.3_Missense_Mutation_p.A4T|PPY_ENST00000587006.1_Missense_Mutation_p.A4T			P01298	PAHO_HUMAN	pancreatic polypeptide	4					digestion|protein secretion	extracellular region	hormone activity			large_intestine(2)|lung(1)|skin(1)	4		Breast(137;0.00314)|Prostate(33;0.0724)		BRCA - Breast invasive adenocarcinoma(366;0.113)		CAGAGGCGTGCGGCAGCCATC	0.657000													5	25					0	0	1	0	0
HUWE1	10075	broad.mit.edu	37	X	53588762	53588762	+	Missense_Mutation	SNP	C	C	G			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chrX:53588762C>G	ENST00000342160.3	-	54	7919	c.7462G>C	c.(7462-7464)Gag>Cag	p.E2488Q	HUWE1_ENST00000262854.6_Missense_Mutation_p.E2488Q			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	2488	Asp-rich.				base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						AGATCATCCTCCCGGTCAAAG	0.458000													5	81					0	0	1	0	0
BAZ2A	11176	broad.mit.edu	37	12	56993130	56993130	+	Missense_Mutation	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr12:56993130C>T	ENST00000179765.5	-	28	5294	c.5095G>A	c.(5095-5097)Gaa>Aaa	p.E1699K	BAZ2A_ENST00000551812.1_Missense_Mutation_p.E1731K|BAZ2A_ENST00000549884.1_Missense_Mutation_p.E1729K|BAZ2A_ENST00000379441.3_Missense_Mutation_p.E1701K			Q9UIF9	BAZ2A_HUMAN	bromodomain adjacent to zinc finger domain, 2A	1731					chromatin silencing at rDNA|DNA methylation|transcription, DNA-dependent	chromatin silencing complex|nucleolus|rDNA heterochromatin	DNA binding|histone acetyl-lysine binding|ligand-dependent nuclear receptor binding|RNA binding|zinc ion binding			breast(1)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(15)|urinary_tract(1)	31						TGAGTGAATTCTCCCTCCACC	0.502000													5	33					0	0	1	0	0
WNK1	65125	broad.mit.edu	37	12	939275	939275	+	Silent	SNP	T	T	C			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr12:939275T>C	ENST00000537687.1	+	4	1903	c.1260T>C	c.(1258-1260)taT>taC	p.Y420Y	WNK1_ENST00000540360.1_3'UTR|WNK1_ENST00000535572.1_Silent_p.Y420Y|WNK1_ENST00000530271.2_Silent_p.Y420Y|WNK1_ENST00000315939.6_Silent_p.Y420Y	NM_001184985.1|NM_213655.4	NP_001171914.1|NP_998820.3	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	420	Protein kinase.				intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			breast(7)|central_nervous_system(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(43)|ovary(6)|prostate(3)|skin(7)|stomach(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	104	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			CATCTGAATATCCTTACTCGG	0.453000													5	109					0	0	1	0	0
SEL1L2	80343	broad.mit.edu	37	20	13912405	13912405	+	Missense_Mutation	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr20:13912405C>T	ENST00000284951.5	-	3	201	c.127G>A	c.(127-129)Gaa>Aaa	p.E43K	SEL1L2_ENST00000378072.5_Missense_Mutation_p.E43K|SEL1L2_ENST00000486903.1_5'UTR			Q5TEA6	SE1L2_HUMAN	sel-1 suppressor of lin-12-like 2 (C. elegans)	43						integral to membrane	binding	p.E43K(1)		cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(14)|lung(25)|ovary(2)|skin(3)|urinary_tract(1)	51						TGTTTGATTTCGTTCACTGAT	0.289000													5	140					0	0	1	0	0
COL25A1	84570	broad.mit.edu	37	4	109861734	109861734	+	Silent	SNP	G	G	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr4:109861734G>A	ENST00000399132.1	-	10	1163	c.633C>T	c.(631-633)gaC>gaT	p.D211D	COL25A1_ENST00000399126.1_Silent_p.D211D|COL25A1_ENST00000399127.1_Silent_p.D207D	NM_198721.2	NP_942014.1	Q9BXS0	COPA1_HUMAN	collagen, type XXV, alpha 1	211	Collagen-like 2.					collagen|extracellular space	beta-amyloid binding|heparin binding			NS(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(19)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	49		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000173)		CTTTCCCTGTGTCCCCAGGTG	0.572000													11	96					0	0	1	0	0
DAB1	1600	broad.mit.edu	37	1	57480832	57480832	+	Missense_Mutation	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr1:57480832C>T	ENST00000371236.2	-	12	1431	c.1168G>A	c.(1168-1170)Gtc>Atc	p.V390I	DAB1_ENST00000414851.2_Missense_Mutation_p.V372I|DAB1_ENST00000439789.2_Missense_Mutation_p.V304I|DAB1_ENST00000485760.1_5'UTR|DAB1_ENST00000371231.1_Missense_Mutation_p.V423I|DAB1_ENST00000371234.4_Missense_Mutation_p.V390I|DAB1_ENST00000420954.2_Missense_Mutation_p.V388I			O75553	DAB1_HUMAN	Dab, reelin signal transducer, homolog 1 (Drosophila)	423					cell differentiation|nervous system development					central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(28)|ovary(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(5)	64						GTGCCTGGGACGGTGGCAAGG	0.587000													13	57					0	0	1	0	0
CHML	1122	broad.mit.edu	37	1	241797719	241797719	+	Silent	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr1:241797719C>T	ENST00000366553.1	-	1	1513	c.1350G>A	c.(1348-1350)caG>caA	p.Q450Q	OPN3_ENST00000331838.5_Intron|OPN3_ENST00000366554.2_Intron|OPN3_ENST00000469376.1_Intron	NM_001821.3	NP_001812.2	P26374	RAE2_HUMAN	choroideremia-like (Rab escort protein 2)	450					intracellular protein transport|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(6)|lung(7)|ovary(4)|skin(3)|stomach(1)	26	Ovarian(103;0.103)|all_lung(81;0.23)	all_cancers(173;0.0231)	OV - Ovarian serous cystadenocarcinoma(106;0.0125)			TCTGCTTATACTGCACATTTG	0.368000													4	163					0	0	1	0	0
POLK	51426	broad.mit.edu	37	5	74892236	74892236	+	Nonsense_Mutation	SNP	C	C	G			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr5:74892236C>G	ENST00000241436.4	+	13	1890	c.1718C>G	c.(1717-1719)tCa>tGa	p.S573*	POLK_ENST00000508526.1_Nonsense_Mutation_p.S375*|POLK_ENST00000380481.3_Nonsense_Mutation_p.S483*|POLK_ENST00000352007.5_Nonsense_Mutation_p.S375*|POLK_ENST00000506928.1_3'UTR|POLK_ENST00000504026.1_Intron	NM_016218.2	NP_057302.1	Q9UBT6	POLK_HUMAN	polymerase (DNA directed) kappa	573					DNA replication|nucleotide-excision repair, DNA gap filling	nucleus	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding			endometrium(1)|kidney(4)|large_intestine(5)|lung(11)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	27		all_lung(232;0.0131)|Lung NSC(167;0.0282)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;2.9e-54)|all cancers(79;1.27e-42)		AAAAAACGATCAGAAAGGAAA	0.343000								DNA polymerases (catalytic subunits)					4	58					0	0	1	0	0
SMARCD3	6604	broad.mit.edu	37	7	150939642	150939642	+	Silent	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr7:150939642C>T	ENST00000392811.2	-	6	939	c.465G>A	c.(463-465)gcG>gcA	p.A155A	SMARCD3_ENST00000262188.8_Silent_p.A168A|SMARCD3_ENST00000356800.2_Silent_p.A155A|SMARCD3_ENST00000477169.1_5'UTR	NM_003078.3	NP_003069.2	Q6STE5	SMRD3_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3	168					cellular lipid metabolic process|chromatin modification|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	nuclear hormone receptor binding|protein binding|transcription coactivator activity|transcription factor binding	p.A155A(3)|p.A168A(1)		haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(6)|ovary(2)	15			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CATCAGGCTTCGCAGGGTTAA	0.577000													65	132					0	0	1	0	0
LACC1	144811	broad.mit.edu	37	13	44455407	44455407	+	Missense_Mutation	SNP	G	G	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr13:44455407G>A	ENST00000441843.1	+	2	771	c.286G>A	c.(286-288)Gat>Aat	p.D96N	LACC1_ENST00000325686.6_Missense_Mutation_p.D96N	NM_001128303.1	NP_001121775.1	Q8IV20	CM031_HUMAN	laccase (multicopper oxidoreductase) domain containing 1	96																	ACAGAAAATTGATGAAAAAAA	0.353000													4	68					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196877574	196877574	+	Missense_Mutation	SNP	A	A	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr2:196877574A>T	ENST00000312428.6	-	10	1026	c.926T>A	c.(925-927)cTg>cAg	p.L309Q	DNAH7_ENST00000410072.1_Missense_Mutation_p.L309Q	NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	309	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						AAAACTTGACAGCTCTAATGC	0.299000													4	90					0	0	1	0	0
HBD	3045	broad.mit.edu	37	11	5255647	5255647	+	Missense_Mutation	SNP	G	G	C			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr11:5255647G>C	ENST00000380299.3	-	1	231	c.17C>G	c.(16-18)cCt>cGt	p.P6R	HBD_ENST00000292901.3_Missense_Mutation_p.P6R	NM_000519.3	NP_000510.1	P02042	HBD_HUMAN	hemoglobin, delta	6					blood coagulation	hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity			endometrium(2)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)	16		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;5.69e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTTCTCCTCAGGAGTCAGATG	0.502000													18	58					0	0	1	0	0
MTMR3	8897	broad.mit.edu	37	22	30405007	30405007	+	Splice_Site	SNP	A	A	G			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr22:30405007A>G	ENST00000333027.3	+	12	1338	c.1009_splice	c.e12-1	p.E337_splice	MTMR3_ENST00000323630.5_Splice_Site_p.E201_splice|CTA-85E5.10_ENST00000429350.1_RNA|MTMR3_ENST00000406629.1_Splice_Site_p.E337_splice|MTMR3_ENST00000401950.2_Splice_Site_p.E337_splice|MTMR3_ENST00000351488.3_Splice_Site_p.E337_splice	NM_153050.2|NM_153051.2	NP_694690.1|NP_694691.1	Q13615	MTMR3_HUMAN	myotubularin related protein 3	337	Myotubularin phosphatase.				phosphatidylinositol dephosphorylation	cytoplasm|membrane|membrane fraction|nucleus	metal ion binding|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			breast(3)|large_intestine(3)|ovary(2)|skin(8)|upper_aerodigestive_tract(1)	17			OV - Ovarian serous cystadenocarcinoma(5;0.00204)|Epithelial(10;0.06)|all cancers(5;0.107)			CTCTCTCCAGAGTATTACCCA	0.418000													16	83					0	0	1	0	0
GPATCH8	23131	broad.mit.edu	37	17	42477204	42477204	+	Silent	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr17:42477204C>T	ENST00000434000.1	-	9	2289	c.2007G>A	c.(2005-2007)agG>agA	p.R669R	GPATCH8_ENST00000591680.1_Silent_p.R747R			Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	747	Lys-rich.					intracellular	nucleic acid binding|zinc ion binding			breast(4)|endometrium(7)|kidney(6)|large_intestine(4)|liver(2)|lung(21)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	50		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		GAGCTCTCCGCCTTCTTCTTG	0.567000													10	112					0	0	1	0	0
PRKAB2	5565	broad.mit.edu	37	1	146639425	146639425	+	Missense_Mutation	SNP	G	G	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr1:146639425G>A	ENST00000254101.3	-	3	382	c.244C>T	c.(244-246)Cgc>Tgc	p.R82C	PRKAB2_ENST00000425272.2_Intron	NM_005399.3	NP_005390.1	O43741	AAKB2_HUMAN	protein kinase, AMP-activated, beta 2 non-catalytic subunit	82					carnitine shuttle|cell cycle arrest|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm				NS(1)|endometrium(1)|large_intestine(2)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	11	all_hematologic(923;0.0487)				Adenosine monophosphate(DB00131)	TCAGACCAGCGGATAACAGTG	0.517000													48	201					0	0	1	0	0
ADCY2	108	broad.mit.edu	37	5	7709343	7709343	+	Missense_Mutation	SNP	A	A	G			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr5:7709343A>G	ENST00000338316.4	+	10	1510	c.1421A>G	c.(1420-1422)cAg>cGg	p.Q474R	ADCY2_ENST00000537121.1_Missense_Mutation_p.Q294R|RP11-711G10.1_ENST00000514105.2_RNA	NM_020546.2	NP_065433.2	Q08462	ADCY2_HUMAN	adenylate cyclase 2 (brain)	474					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(56)|ovary(8)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	119						CGGAGCCCCCAGCATCTCTTC	0.582000													5	68					0	0	1	0	0
PRMT5	10419	broad.mit.edu	37	14	23393710	23393710	+	Missense_Mutation	SNP	C	C	G			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr14:23393710C>G	ENST00000324366.8	-	10	1277	c.1054G>C	c.(1054-1056)Gag>Cag	p.E352Q	PRMT5_ENST00000216350.8_Missense_Mutation_p.E291Q|PRMT5-AS1_ENST00000595662.1_RNA|PRMT5-AS1_ENST00000599580.1_RNA|PRMT5_ENST00000397440.4_Missense_Mutation_p.E181Q|PRMT5-AS1_ENST00000590290.1_RNA|PRMT5_ENST00000538452.1_Missense_Mutation_p.E246Q|PRMT5_ENST00000553897.1_Missense_Mutation_p.E308Q|PRMT5-AS1_ENST00000587245.2_RNA|PRMT5_ENST00000397441.2_Missense_Mutation_p.E335Q	NM_006109.3	NP_006100.2	O14744	ANM5_HUMAN	protein arginine methyltransferase 5	352					cell proliferation|histone H4-R3 methylation|ncRNA metabolic process|regulation of mitosis|spliceosomal snRNP assembly|transcription, DNA-dependent	cytosol|nucleus	histone-arginine N-methyltransferase activity|protein binding|protein-arginine omega-N symmetric methyltransferase activity|ribonucleoprotein binding			endometrium(4)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	25	all_cancers(95;2.76e-05)			GBM - Glioblastoma multiforme(265;0.0126)		TCCTTCTCCTCTTCTGGTACT	0.493000													11	112					0	0	1	0	0
GLTPD1	80772	broad.mit.edu	37	1	1262674	1262674	+	Missense_Mutation	SNP	C	C	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr1:1262674C>A	ENST00000343938.4	+	3	587	c.176C>A	c.(175-177)tCc>tAc	p.S59Y	GLTPD1_ENST00000464957.1_3'UTR	NM_001029885.1	NP_001025056.1	Q5TA50	GLTD1_HUMAN	glycolipid transfer protein domain containing 1	59						cytoplasm	glycolipid binding|glycolipid transporter activity			lung(1)	1	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;4.95e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		GACGTGGTCTCCAAGCTGCGG	0.662000													15	52					1.5739e-10	1.72779e-10	1	1	0
MSH3	4437	broad.mit.edu	37	5	80057395	80057395	+	Silent	SNP	G	G	A	rs61753791	byFrequency	TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr5:80057395G>A	ENST00000265081.6	+	13	1874	c.1794G>A	c.(1792-1794)tcG>tcA	p.S598S	MSH3_ENST00000512258.1_3'UTR	NM_002439.4	NP_002430.3	P20585	MSH3_HUMAN	mutS homolog 3	598					maintenance of DNA repeat elements|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|somatic recombination of immunoglobulin gene segments	MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|enzyme binding|loop DNA binding|Y-form DNA binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(12)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	29		Lung NSC(167;0.00479)|all_lung(232;0.00507)|Ovarian(174;0.0261)|Breast(144;0.244)		OV - Ovarian serous cystadenocarcinoma(54;2.38e-45)|Epithelial(54;1.58e-38)|all cancers(79;4.93e-33)		ATGCTGTATCGGAAGTTCTCC	0.378000								Mismatch excision repair (MMR)					4	108					0	0	1	0	0
BAG5	9529	broad.mit.edu	37	14	104026872	104026872	+	Missense_Mutation	SNP	A	A	C			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr14:104026872A>C	ENST00000445922.2	-	2	876	c.630T>G	c.(628-630)aaT>aaG	p.N210K	RP11-894P9.2_ENST00000556332.1_RNA|BAG5_ENST00000337322.4_Missense_Mutation_p.N251K|BAG5_ENST00000299204.4_Missense_Mutation_p.N210K	NM_004873.3	NP_004864.1	Q9UL15	BAG5_HUMAN	BCL2-associated athanogene 5	210	BAG 3.				apoptosis|negative regulation of protein refolding|negative regulation of ubiquitin-protein ligase activity|neuron death|protein folding|regulation of inclusion body assembly	inclusion body|perinuclear region of cytoplasm	chaperone binding|ubiquitin protein ligase binding			endometrium(5)|large_intestine(4)|lung(7)|ovary(2)|prostate(2)|skin(2)|urinary_tract(2)	24		Melanoma(154;0.155)	Epithelial(46;0.144)			TGCAGGTCTCATTGTTGTTCA	0.527000													36	94					0	0	1	0	0
SLC5A4	6527	broad.mit.edu	37	22	32651253	32651253	+	Missense_Mutation	SNP	G	G	C			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr22:32651253G>C	ENST00000266086.4	-	1	75	c.64C>G	c.(64-66)Cac>Gac	p.H22D	RP1-90G24.10_ENST00000434942.1_RNA	NM_014227.2	NP_055042.1	Q9NY91	SC5A4_HUMAN	solute carrier family 5 (glucose activated ion channel), member 4	22					carbohydrate transport|sodium ion transport	integral to membrane	symporter activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(15)|pancreas(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						TTTCGGATGTGGTCAGACAAT	0.542000											OREG0003502	type=REGULATORY REGION|Gene=SLC5A4|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	44	183					0	0	1	0	0
NKPD1	284353	broad.mit.edu	37	19	45655798	45655798	+	Missense_Mutation	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr19:45655798C>T	ENST00000317951.4	-	4	1896	c.1897G>A	c.(1897-1899)Gtg>Atg	p.V633M	NKPD1_ENST00000438936.2_Missense_Mutation_p.V411M|NKPD1_ENST00000589776.1_Missense_Mutation_p.V411M|NKPD1_ENST00000429338.1_Missense_Mutation_p.V411M	NM_198478.3	NP_940880.3			NTPase, KAP family P-loop domain containing 1											endometrium(1)|lung(4)|prostate(2)|urinary_tract(1)	8		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00863)|GBM - Glioblastoma multiforme(486;0.231)		AGCAGGCGCACGGTGATGGGC	0.697000													3	30					0	0	1	0	0
KIAA1377	57562	broad.mit.edu	37	11	101833080	101833080	+	Missense_Mutation	SNP	G	G	C			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr11:101833080G>C	ENST00000263468.8	+	6	1584	c.1314G>C	c.(1312-1314)gaG>gaC	p.E438D	KIAA1377_ENST00000537689.1_Missense_Mutation_p.E239D	NM_020802.2	NP_065853.2	Q9P2H0	K1377_HUMAN	KIAA1377	438							protein binding			breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(18)|ovary(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	53	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)		CAGACCAAGAGAAATATTCTG	0.378000													5	82					0	0	1	0	0
UBL7	84993	broad.mit.edu	37	15	74741683	74741683	+	Silent	SNP	G	G	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr15:74741683G>A	ENST00000567435.1	-	9	1189	c.726C>T	c.(724-726)tcC>tcT	p.S242S	UBL7_ENST00000395081.2_Silent_p.S242S|UBL7_ENST00000361351.4_Silent_p.S242S|UBL7_ENST00000564488.1_Silent_p.S242S|UBL7_ENST00000565335.1_Silent_p.S242S			Q96S82	UBL7_HUMAN	ubiquitin-like 7 (bone marrow stromal cell-derived)	242							protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|skin(1)	9						TAGAGGGTGTGGACCTGGTGT	0.597000													5	27					0	0	1	0	0
HYOU1	10525	broad.mit.edu	37	11	118917447	118917447	+	Nonsense_Mutation	SNP	G	G	C			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr11:118917447G>C	ENST00000404233.3	-	23	2787	c.2663C>G	c.(2662-2664)tCa>tGa	p.S888*	HYOU1_ENST00000525859.1_Nonsense_Mutation_p.S826*|HYOU1_ENST00000529972.1_Nonsense_Mutation_p.S826*	NM_001130991.1|NM_006389.3	NP_001124463.1|NP_006380.1	Q9Y4L1	HYOU1_HUMAN	hypoxia up-regulated 1	888						endoplasmic reticulum lumen	ATP binding|protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(10)|prostate(1)|skin(2)	33	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)|all_hematologic(192;0.207)		BRCA - Breast invasive adenocarcinoma(274;7.78e-05)		AATGTCTTTTGAGAGCAACAC	0.567000													5	133					0	0	1	0	0
EGR2	1959	broad.mit.edu	37	10	64573000	64573000	+	Silent	SNP	G	G	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr10:64573000G>A	ENST00000242480.3	-	2	1723	c.1398C>T	c.(1396-1398)ctC>ctT	p.L466L	EGR2_ENST00000439032.1_Silent_p.L466L|EGR2_ENST00000411732.1_Silent_p.L416L	NM_000399.3|NM_001136177.1	NP_000390.2|NP_001129649.1	P11161	EGR2_HUMAN	early growth response 2	466					fat cell differentiation|protein export from nucleus|transcription from RNA polymerase II promoter	cytoplasm|nucleus	chromatin binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|ubiquitin protein ligase binding|zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(10)|lung(13)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)	36	Prostate(12;0.0297)|all_hematologic(501;0.228)					AGCAAGGGGCGAGCGGCCCTC	0.652000													25	110					0	0	1	0	0
ESF1	51575	broad.mit.edu	37	20	13747568	13747568	+	Nonsense_Mutation	SNP	C	C	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr20:13747568C>A	ENST00000202816.1	-	8	1629	c.1522G>T	c.(1522-1524)Gaa>Taa	p.E508*		NM_001276380.1|NM_016649.3	NP_001263309.1|NP_057733.2	Q9H501	ESF1_HUMAN	ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)	508					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|nucleoplasm				endometrium(3)|kidney(5)|large_intestine(8)|lung(11)|ovary(2)|skin(1)|stomach(1)	31						CAAGTGATTTCCACCTTTCAC	0.338000													33	83					1.62565e-12	1.80872e-12	1	1	0
MYO1G	64005	broad.mit.edu	37	7	45009308	45009308	+	Missense_Mutation	SNP	C	C	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr7:45009308C>A	ENST00000258787.7	-	11	1635	c.1499G>T	c.(1498-1500)cGc>cTc	p.R500L		NM_033054.2	NP_149043.2	B0I1T2	MYO1G_HUMAN	myosin IG	500	Myosin head-like.					myosin complex|plasma membrane	actin binding|ATP binding|calmodulin binding|motor activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|pancreas(1)|skin(4)	28						GGGCACCTGGCGGCTGGTGTA	0.667000													20	121					8.10497e-08	8.70404e-08	1	1	0
SEC14L1	6397	broad.mit.edu	37	17	75201375	75201375	+	Missense_Mutation	SNP	A	A	C			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr17:75201375A>C	ENST00000413679.2	+	11	1419	c.1116A>C	c.(1114-1116)gaA>gaC	p.E372D	SEC14L1_ENST00000430767.4_Missense_Mutation_p.E372D|SEC14L1_ENST00000431431.2_Missense_Mutation_p.E338D|SEC14L1_ENST00000436233.4_Missense_Mutation_p.E372D|SEC14L1_ENST00000591437.1_Missense_Mutation_p.E338D|SEC14L1_ENST00000585618.1_Missense_Mutation_p.E372D|SEC14L1_ENST00000392476.2_Missense_Mutation_p.E372D|SEC14L1_ENST00000443798.4_Missense_Mutation_p.E372D	NM_001143998.1|NM_001143999.1|NM_003003.3	NP_001137470.1|NP_001137471.1|NP_002994.3	Q92503	S14L1_HUMAN	SEC14-like 1 (S. cerevisiae)	372	CRAL-TRIO.				transport	Golgi apparatus|integral to membrane	binding			NS(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(2)	31						CCATAAATGAAGAAGGGCTAA	0.403000													11	74					0	0	1	0	0
RAB41	347517	broad.mit.edu	37	X	69502411	69502411	+	Silent	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chrX:69502411C>T	ENST00000374473.2	+	2	199	c.153C>T	c.(151-153)ttC>ttT	p.F51F	RAB41_ENST00000276066.4_Silent_p.F50F			Q5JT25	RAB41_HUMAN	RAB41, member RAS oncogene family	51					protein transport|small GTPase mediated signal transduction		GTP binding			breast(2)|endometrium(4)|large_intestine(2)|lung(4)|ovary(2)	14						TCAGCCGCTTCATGTACAACA	0.537000													14	66					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11845708	11845708	+	Missense_Mutation	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr17:11845708C>T	ENST00000262442.3	+	67	12817	c.12749C>T	c.(12748-12750)cCt>cTt	p.P4250L	DNAH9_ENST00000454412.2_Missense_Mutation_p.P4174L|DNAH9_ENST00000396001.2_Missense_Mutation_p.P562L	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	4250					cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GAGCGCACCCCTTACATTGTA	0.537000													19	80					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103428220	103428220	+	Nonsense_Mutation	SNP	C	C	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr1:103428220C>A	ENST00000358392.2	-	39	3366	c.3049G>T	c.(3049-3051)Gaa>Taa	p.E1017*	COL11A1_ENST00000370096.3_Nonsense_Mutation_p.E1005*|COL11A1_ENST00000512756.1_Nonsense_Mutation_p.E889*|COL11A1_ENST00000353414.4_Nonsense_Mutation_p.E966*	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	1005	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging	p.E1005K(1)|p.E1017K(1)		NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TTTGCACCTTCTTTTCCTGCA	0.468000													15	56					0.000308642	0.000316326	1	1	0
COL22A1	169044	broad.mit.edu	37	8	139793188	139793188	+	Silent	SNP	G	G	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr8:139793188G>A	ENST00000303045.6	-	13	2078	c.1632C>T	c.(1630-1632)gaC>gaT	p.D544D	COL22A1_ENST00000435777.1_Silent_p.D544D	NM_152888.1	NP_690848.1	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	544	Collagen-like 2.|Gly-rich.|Pro-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			CTTTGCTGCCGTCTCTCCCAG	0.527000										HNSCC(7;0.00092)			33	74					0	0	1	0	0
KIF3B	9371	broad.mit.edu	37	20	30898675	30898675	+	Silent	SNP	C	C	G			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr20:30898675C>G	ENST00000375712.3	+	2	1262	c.1095C>G	c.(1093-1095)ctC>ctG	p.L365L	KIF3B_ENST00000418717.2_Silent_p.L53L	NM_004798.3	NP_004789.1	O15066	KIF3B_HUMAN	kinesin family member 3B	365					anterograde axon cargo transport|blood coagulation|determination of left/right symmetry|mitotic centrosome separation|plus-end-directed vesicle transport along microtubule|spindle assembly involved in mitosis	centrosome|cytosol|kinesin II complex|plus-end kinesin complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|Rho GTPase binding			NS(2)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(5)|lung(9)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	36			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			TTGCTCGGCTCAAGGCCCAGC	0.557000													5	53					0	0	1	0	0
ATP6AP2	10159	broad.mit.edu	37	X	40456836	40456836	+	Missense_Mutation	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chrX:40456836C>T	ENST00000378438.4	+	5	612	c.454C>T	c.(454-456)Cgc>Tgc	p.R152C	ATP6AP2_ENST00000544975.1_Missense_Mutation_p.R76C|ATP6AP2_ENST00000535777.1_Intron|ATP6AP2_ENST00000535539.1_Missense_Mutation_p.R120C|ATP6AP2_ENST00000486558.1_3'UTR	NM_005765.2	NP_005756.2	O75787	RENR_HUMAN	ATPase, H+ transporting, lysosomal accessory protein 2	152					angiotensin maturation|positive regulation of transforming growth factor-beta1 production|regulation of MAPKKK cascade	external side of plasma membrane|integral to membrane	protein binding|receptor activity			endometrium(1)|large_intestine(1)|lung(2)	4						AGTCACCTTGCGCCAGCTCCG	0.408000													26	172					0	0	1	0	0
SUSD3	203328	broad.mit.edu	37	9	95838220	95838220	+	Silent	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr9:95838220C>T	ENST00000375472.3	+	2	279	c.243C>T	c.(241-243)atC>atT	p.I81I	SUSD3_ENST00000375469.1_Silent_p.I68I	NM_145006.2	NP_659443.1	Q96L08	SUSD3_HUMAN	sushi domain containing 3	81	Sushi.					integral to membrane				NS(1)|autonomic_ganglia(1)|breast(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|skin(2)	13						AGGGGAGCATCGCTGAGTGGT	0.637000													8	98					0	0	1	0	0
LRP12	29967	broad.mit.edu	37	8	105503260	105503260	+	Missense_Mutation	SNP	G	G	A	rs141755380		TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr8:105503260G>A	ENST00000276654.5	-	7	2329	c.2221C>T	c.(2221-2223)Cgt>Tgt	p.R741C	LRP12_ENST00000518375.1_5'UTR|LRP12_ENST00000424843.2_Missense_Mutation_p.R722C	NM_013437.4	NP_038465.1	Q9Y561	LRP12_HUMAN	low density lipoprotein receptor-related protein 12	741					endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding			NS(1)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	48			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)			AATGTAAAACGTACCCAGCGT	0.478000													37	76					0	0	1	0	0
FCRL1	115350	broad.mit.edu	37	1	157767980	157767980	+	Missense_Mutation	SNP	G	G	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr1:157767980G>A	ENST00000358292.3	-	7	1019	c.968C>T	c.(967-969)cCa>cTa	p.P323L	FCRL1_ENST00000489998.1_5'UTR|FCRL1_ENST00000491942.1_Missense_Mutation_p.P362L|FCRL1_ENST00000368176.3_Missense_Mutation_p.P362L	NM_001159397.1	NP_001152869.1	Q96LA6	FCRL1_HUMAN	Fc receptor-like 1	362						integral to membrane|plasma membrane	receptor activity	p.P323R(2)|p.P362R(2)		breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(24)|ovary(4)|prostate(1)|skin(6)	42	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			TAGCTGCCCTGGGGTAGGTGA	0.498000													6	27					0	0	1	0	0
NRD1	4898	broad.mit.edu	37	1	52281999	52281999	+	Missense_Mutation	SNP	G	G	C			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr1:52281999G>C	ENST00000354831.7	-	13	1817	c.1628C>G	c.(1627-1629)tCt>tGt	p.S543C	NRD1_ENST00000485608.1_5'UTR|NRD1_ENST00000544028.1_Missense_Mutation_p.S343C|NRD1_ENST00000352171.7_Missense_Mutation_p.S475C|NRD1_ENST00000539524.1_Missense_Mutation_p.S411C	NM_002525.2	NP_002516.2	O43847	NRDC_HUMAN	nardilysin (N-arginine dibasic convertase)	474					cell migration|cell proliferation|neuromuscular junction development|positive regulation of membrane protein ectodomain proteolysis|proteolysis|regulation of endopeptidase activity	cell surface|cytosol	epidermal growth factor binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(9)|pancreas(1)|prostate(1)|skin(1)	27						CCTAAGGAAAGAAAGAATGCT	0.299000													8	64					0	0	1	0	0
ARHGAP9	64333	broad.mit.edu	37	12	57868256	57868256	+	Missense_Mutation	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr12:57868256C>T	ENST00000393797.2	-	18	2195	c.2003G>A	c.(2002-2004)cGt>cAt	p.R668H	ARHGAP9_ENST00000550288.1_Missense_Mutation_p.R657H|ARHGAP9_ENST00000424809.2_Missense_Mutation_p.R578H|ARHGAP9_ENST00000430041.2_Missense_Mutation_p.R394H|ARHGAP9_ENST00000393791.3_Missense_Mutation_p.R578H|ARHGAP9_ENST00000356411.2_Missense_Mutation_p.R597H			Q9BRR9	RHG09_HUMAN	Rho GTPase activating protein 9	597	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			endometrium(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(1)	30			GBM - Glioblastoma multiforme(3;3.37e-34)			GGTGACCGCACGCTCTGCAAC	0.517000													20	42					0	0	1	0	0
EPN3	55040	broad.mit.edu	37	17	48619236	48619236	+	Silent	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr17:48619236C>T	ENST00000268933.3	+	10	2196	c.1617C>T	c.(1615-1617)ttC>ttT	p.F539F	EPN3_ENST00000537145.1_Silent_p.F567F|EPN3_ENST00000541226.1_3'UTR	NM_017957.2	NP_060427.2	Q9H201	EPN3_HUMAN	epsin 3	539	3 X 3 AA repeats of N-P-F.					clathrin-coated vesicle|nucleus|perinuclear region of cytoplasm	lipid binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(1)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	14	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;2.88e-09)			CCAACCCGTTCGGCGCGGGCG	0.716000													5	43					0	0	1	0	0
LONRF3	79836	broad.mit.edu	37	X	118108892	118108892	+	Missense_Mutation	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chrX:118108892C>T	ENST00000365713.2	+	1	312	c.149C>T	c.(148-150)cCg>cTg	p.P50L	LONRF3_ENST00000371628.3_Missense_Mutation_p.P50L|LONRF3_ENST00000304778.7_Missense_Mutation_p.P50L			Q496Y0	LONF3_HUMAN	LON peptidase N-terminal domain and ring finger 3	50					proteolysis		ATP-dependent peptidase activity|protein binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(17)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	36						GCACCTCTACCGACGCGGGAG	0.677000													4	13					0	0	1	0	0
HSPB2	3316	broad.mit.edu	37	11	111784374	111784374	+	Missense_Mutation	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr11:111784374C>T	ENST00000304298.3	+	2	892	c.304C>T	c.(304-306)Cgg>Tgg	p.R102W	CRYAB_ENST00000533475.1_5'UTR|HSPB2_ENST00000537382.1_Missense_Mutation_p.R102W|HSPB2-C11orf52_ENST00000534100.1_Intron|CRYAB_ENST00000527950.1_Intron	NM_001541.3	NP_001532.1	Q16082	HSPB2_HUMAN	heat shock 27kDa protein 2	102					response to heat|response to unfolded protein	cytosol|nucleus	enzyme activator activity|protein binding			large_intestine(2)|lung(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	10		all_cancers(61;3.75e-11)|all_epithelial(67;2.33e-06)|Melanoma(852;9.42e-06)|all_hematologic(158;0.000885)|Acute lymphoblastic leukemia(157;0.000966)|Breast(348;0.0512)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)		Epithelial(105;3.57e-07)|BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|all cancers(92;6.57e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.051)		GGTGTCTGCCCGGCACCCCCA	0.627000													11	74					0	0	1	0	0
UBTF	7343	broad.mit.edu	37	17	42293957	42293957	+	Silent	SNP	T	T	C			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr17:42293957T>C	ENST00000302904.4	-	3	666	c.174A>G	c.(172-174)gtA>gtG	p.V58V	UBTF_ENST00000393606.3_Silent_p.V58V|UBTF_ENST00000343638.5_Silent_p.V58V|UBTF_ENST00000529383.1_Silent_p.V58V|UBTF_ENST00000537550.1_5'UTR|UBTF_ENST00000527034.1_Silent_p.V58V|UBTF_ENST00000533177.1_Silent_p.V58V|UBTF_ENST00000526094.1_Silent_p.V58V|UBTF_ENST00000436088.1_Silent_p.V58V			P17480	UBF1_HUMAN	upstream binding transcription factor, RNA polymerase I	58					positive regulation of transcription from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleolus|nucleoplasm	DNA binding|protein binding			breast(1)|central_nervous_system(2)|endometrium(1)|large_intestine(9)|lung(10)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Breast(137;0.00765)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.114)		CTTTAAATGCTACTTTTTCCC	0.438000													135	222					0	0	1	0	0
LRFN4	78999	broad.mit.edu	37	11	66625772	66625772	+	Missense_Mutation	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr11:66625772C>T	ENST00000309602.4	+	1	800	c.557C>T	c.(556-558)cCa>cTa	p.P186L	PC_ENST00000393960.1_Intron|PC_ENST00000393958.2_Intron|LRFN4_ENST00000393952.3_Missense_Mutation_p.P186L|PC_ENST00000393955.2_Intron	NM_024036.4	NP_076941.2	Q6PJG9	LRFN4_HUMAN	leucine rich repeat and fibronectin type III domain containing 4	186						integral to membrane				breast(1)|lung(1)|prostate(1)	3						GCACTGCCCCCAGGCGCCTTC	0.667000													8	34					0	0	1	0	0
POM121	9883	broad.mit.edu	37	7	72398976	72398976	+	Missense_Mutation	SNP	A	A	G	rs147859349		TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr7:72398976A>G	ENST00000395270.1	+	7	1322	c.281A>G	c.(280-282)aAt>aGt	p.N94S	POM121_ENST00000434423.2_Missense_Mutation_p.N359S|POM121_ENST00000446813.1_Missense_Mutation_p.N94S|POM121_ENST00000257622.4_Missense_Mutation_p.N94S|POM121_ENST00000358357.3_Missense_Mutation_p.N94S	NM_001257190.1	NP_001244119.1	Q96HA1	P121A_HUMAN	POM121 transmembrane nucleoporin	359	Pore side (Potential).|Required for targeting to the nucleus and nuclear pore complex.				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|breast(1)|endometrium(9)|kidney(4)|large_intestine(6)|lung(12)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Lung NSC(55;0.163)				CTGGTGGCCAATGGAGTCCCC	0.468000													5	284					0	0	1	0	0
IKBKB	3551	broad.mit.edu	37	8	42176072	42176072	+	Nonsense_Mutation	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr8:42176072C>T	ENST00000520810.1	+	13	1429	c.1243C>T	c.(1243-1245)Caa>Taa	p.Q415*	IKBKB_ENST00000379708.3_Nonsense_Mutation_p.Q192*|IKBKB_ENST00000416505.2_Nonsense_Mutation_p.Q356*|IKBKB_ENST00000522147.1_Intron|IKBKB_ENST00000520835.1_Nonsense_Mutation_p.Q413*	NM_001556.2	NP_001547.1	O14920	IKKB_HUMAN	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	415					anti-apoptosis|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|membrane raft	ATP binding|identical protein binding|IkappaB kinase activity			breast(4)|lung(1)|ovary(2)|skin(1)	8	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;6.21e-12)|Lung NSC(13;1.04e-10)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;1.37e-10)|Colorectal(10;0.00102)|OV - Ovarian serous cystadenocarcinoma(14;0.00168)|Lung(22;0.00467)|LUSC - Lung squamous cell carcinoma(45;0.024)|COAD - Colon adenocarcinoma(11;0.0264)		Arsenic trioxide(DB01169)|Auranofin(DB00995)	GTCTCCAGTTCAAGAGCCCAA	0.498000													53	41					0	0	1	0	0
NFE2L3	9603	broad.mit.edu	37	7	26224783	26224783	+	Missense_Mutation	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr7:26224783C>T	ENST00000056233.3	+	4	1724	c.1465C>T	c.(1465-1467)Ctt>Ttt	p.L489F		NM_004289.6	NP_004280.5	Q9Y4A8	NF2L3_HUMAN	nuclear factor, erythroid 2-like 3	489					transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)|skin(5)|urinary_tract(7)	29						CCATGGAGATCTTACATTTCA	0.438000													30	164					0	0	1	0	0
TECTA	7007	broad.mit.edu	37	11	120996150	120996150	+	Missense_Mutation	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr11:120996150C>T	ENST00000392793.1	+	8	1614	c.1343C>T	c.(1342-1344)tCc>tTc	p.S448F	TECTA_ENST00000264037.2_Missense_Mutation_p.S448F			O75443	TECTA_HUMAN	tectorin alpha	448	VWFD 1.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		GCCTCCATTTCCGTCCCAGGC	0.507000													10	404					0	0	1	0	0
XAGE5	170627	broad.mit.edu	37	X	52841625	52841625	+	Missense_Mutation	SNP	G	G	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chrX:52841625G>T	ENST00000375503.3	+	1	398	c.35G>T	c.(34-36)cGa>cTa	p.R12L	XAGE5_ENST00000425386.1_Missense_Mutation_p.R12L|XAGE5_ENST00000351072.1_Missense_Mutation_p.R12L|XAGE5_ENST00000375501.1_Missense_Mutation_p.R12L			Q8WWM1	GAGD5_HUMAN	X antigen family, member 5	12										endometrium(1)|large_intestine(1)|lung(5)|ovary(1)	8						AGACCAAGACGATGTTTACGA	0.433000													8	159					0.00621372	0.00629011	1	1	0
KCNE3	10008	broad.mit.edu	37	11	74168573	74168573	+	Silent	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr11:74168573C>T	ENST00000310128.4	-	3	455	c.36G>A	c.(34-36)gaG>gaA	p.E12E	KCNE3_ENST00000525550.1_Silent_p.E12E|RP11-702H23.4_ENST00000533008.1_RNA	NM_005472.4	NP_005463.1	Q9Y6H6	KCNE3_HUMAN	potassium voltage-gated channel, Isk-related family, member 3	12						integral to membrane	voltage-gated potassium channel activity			cervix(1)|large_intestine(1)|lung(1)|ovary(1)	4	Breast(11;2.86e-06)					CATGCAGGCTCTCATACCAGG	0.552000													10	56					0	0	1	0	0
CLVS1	157807	broad.mit.edu	37	8	62289331	62289331	+	Missense_Mutation	SNP	G	G	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr8:62289331G>A	ENST00000519846.1	+	4	1095	c.623G>A	c.(622-624)gGg>gAg	p.G208E	CLVS1_ENST00000518592.1_5'UTR|CLVS1_ENST00000325897.4_Missense_Mutation_p.G208E			Q8IUQ0	CLVS1_HUMAN	clavesin 1	208	CRAL-TRIO.				lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			endometrium(3)|kidney(4)|large_intestine(4)|lung(21)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	41						GCCATTGAAGGGTTGCAGGTA	0.358000													43	64					0	0	1	0	0
COLEC11	78989	broad.mit.edu	37	2	3691387	3691387	+	Silent	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr2:3691387C>T	ENST00000403096.3	+	6	908	c.417C>T	c.(415-417)gaC>gaT	p.D139D	COLEC11_ENST00000236693.7_Silent_p.D162D|COLEC11_ENST00000404205.1_Silent_p.D91D|COLEC11_ENST00000402794.1_Silent_p.D115D|COLEC11_ENST00000402922.1_Silent_p.D115D|COLEC11_ENST00000382062.2_Silent_p.D141D|COLEC11_ENST00000487365.1_3'UTR|COLEC11_ENST00000349077.4_Silent_p.D165D|COLEC11_ENST00000418971.2_Silent_p.D179D	NM_001255986.1	NP_001242915.1	Q9BWP8	COL11_HUMAN	collectin sub-family member 11	165						collagen	mannose binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|skin(1)|soft_tissue(1)	22	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)			OV - Ovarian serous cystadenocarcinoma(76;0.127)		GCTACGCGGACGCCCAGCTGT	0.662000													21	56					0	0	1	0	0
CARS	833	broad.mit.edu	37	11	3028178	3028178	+	Silent	SNP	G	G	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr11:3028178G>A	ENST00000397114.3	-	19	2177	c.1801C>T	c.(1801-1803)Ctg>Ttg	p.L601L	CARS_ENST00000380525.4_Silent_p.L694L|CARS_ENST00000397111.5_Silent_p.L611L|CARS_ENST00000401769.3_Silent_p.L624L|CARS_ENST00000470221.2_5'UTR|CARS_ENST00000278224.9_Silent_p.L611L			P49589	SYCC_HUMAN	cysteinyl-tRNA synthetase	611					cysteinyl-tRNA aminoacylation	cytoplasm|cytosol	ATP binding|cysteine-tRNA ligase activity|metal ion binding|protein homodimerization activity|tRNA binding		CARS/ALK(5)	central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(14)|ovary(3)|skin(1)	31		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00317)|LUSC - Lung squamous cell carcinoma(625;0.218)	L-Cysteine(DB00151)	CTGAGCTGCAGAATCTCAGGG	0.602000			T	ALK	ALCL								8	153					0	0	1	0	0
POLK	51426	broad.mit.edu	37	5	74892409	74892409	+	Missense_Mutation	SNP	C	C	G			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr5:74892409C>G	ENST00000241436.4	+	13	2063	c.1891C>G	c.(1891-1893)Caa>Gaa	p.Q631E	POLK_ENST00000508526.1_Missense_Mutation_p.Q433E|POLK_ENST00000380481.3_Missense_Mutation_p.Q541E|POLK_ENST00000352007.5_Missense_Mutation_p.Q433E|POLK_ENST00000506928.1_3'UTR|POLK_ENST00000504026.1_Intron	NM_016218.2	NP_057302.1	Q9UBT6	POLK_HUMAN	polymerase (DNA directed) kappa	631					DNA replication|nucleotide-excision repair, DNA gap filling	nucleus	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding			endometrium(1)|kidney(4)|large_intestine(5)|lung(11)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	27		all_lung(232;0.0131)|Lung NSC(167;0.0282)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;2.9e-54)|all cancers(79;1.27e-42)		CTTTAGGGCTCAAGGGTGCAT	0.373000								DNA polymerases (catalytic subunits)					6	153					0	0	1	0	0
MSH4	4438	broad.mit.edu	37	1	76282183	76282183	+	Missense_Mutation	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr1:76282183C>T	ENST00000263187.3	+	6	1045	c.941C>T	c.(940-942)tCa>tTa	p.S314L		NM_002440.3	NP_002431.2	O15457	MSH4_HUMAN	mutS homolog 4	314					chiasma assembly|homologous chromosome segregation|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			breast(1)|endometrium(2)|kidney(4)|large_intestine(9)|lung(26)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	47						ATGATAGATTCATCATCAGCC	0.279000								Mismatch excision repair (MMR)					19	46					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9058944	9058944	+	Missense_Mutation	SNP	G	G	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr19:9058944G>T	ENST00000397910.4	-	3	28705	c.28502C>A	c.(28501-28503)gCc>gAc	p.A9501D		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9503	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TTTAGAAGCGGCCAGACTCTC	0.478000													30	153					1.7881e-09	1.95425e-09	1	1	0
DCAF12L1	139170	broad.mit.edu	37	X	125685745	125685745	+	Missense_Mutation	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chrX:125685745C>T	ENST00000371126.1	-	1	1089	c.847G>A	c.(847-849)Gac>Aac	p.D283N		NM_178470.4	NP_848565.2	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	283										breast(1)|central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(39)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68						AAGTAGCCGTCCAAGGACACC	0.622000													8	93					0	0	1	0	0
PTGDS	5730	broad.mit.edu	37	9	139872000	139872000	+	Translation_Start_Site	SNP	A	A	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr9:139872000A>T	ENST00000224167.2	+	0	45				PTGDS_ENST00000371625.3_De_novo_Start_OutOfFrame			P41222	PTGDS_HUMAN	prostaglandin D2 synthase 21kDa (brain)						prostaglandin biosynthetic process|regulation of circadian sleep/wake cycle, sleep	Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum	fatty acid binding|prostaglandin-D synthase activity|retinoid binding|transporter activity			endometrium(2)|kidney(1)|lung(3)|ovary(1)	7	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.19)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		CACTGGCACCAGGCCCCGGAC	0.667000													6	8					0	0	1	0	0
IPO7	10527	broad.mit.edu	37	11	9455312	9455312	+	Nonsense_Mutation	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr11:9455312C>T	ENST00000379719.3	+	18	2135	c.1993C>T	c.(1993-1995)Caa>Taa	p.Q665*		NM_006391.2	NP_006382.1	O95373	IPO7_HUMAN	importin 7	665					interspecies interaction between organisms|signal transduction	Golgi apparatus|nuclear pore|soluble fraction	protein transporter activity|Ran GTPase binding|small GTPase regulator activity			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(12)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				all cancers(16;8.29e-09)|Epithelial(150;4.76e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0217)		TTTGACATGTCAACAAGTGTC	0.398000													18	71					0	0	1	0	0
NBEA	26960	broad.mit.edu	37	13	35733561	35733561	+	Missense_Mutation	SNP	G	G	C			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr13:35733561G>C	ENST00000540320.1	+	22	3787	c.3253G>C	c.(3253-3255)Gag>Cag	p.E1085Q	NBEA_ENST00000400445.3_Missense_Mutation_p.E1085Q|NBEA_ENST00000379939.2_Missense_Mutation_p.E1085Q|NBEA_ENST00000310336.4_Missense_Mutation_p.E1085Q			Q8NFP9	NBEA_HUMAN	neurobeachin	1085						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		AGTAGGTGGAGAGAATGGTGC	0.393000													10	14					0	0	1	0	0
PDZD4	57595	broad.mit.edu	37	X	153070325	153070325	+	Missense_Mutation	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chrX:153070325C>T	ENST00000164640.4	-	8	984	c.793G>A	c.(793-795)Gat>Aat	p.D265N	PDZD4_ENST00000544474.1_Missense_Mutation_p.D156N|PDZD4_ENST00000393758.2_Missense_Mutation_p.D190N	NM_032512.2	NP_115901.2	Q76G19	PDZD4_HUMAN	PDZ domain containing 4	265						cell cortex				breast(3)|cervix(1)|endometrium(5)|lung(13)|skin(1)	23	all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GGGCCGGCATCGGGAGCCCCC	0.632000													23	49					0	0	1	0	0
LHX2	9355	broad.mit.edu	37	9	126777643	126777643	+	Missense_Mutation	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr9:126777643C>T	ENST00000373615.4	+	3	1305	c.566C>T	c.(565-567)gCg>gTg	p.A189V		NM_004789.3	NP_004780.3	P50458	LHX2_HUMAN	LIM homeobox 2	189	Poly-Ala.					nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|prostate(1)	10						GTGGCAGCGGCGGCCGCTGCA	0.677000													9	53					0	0	1	0	0
FOLH1	2346	broad.mit.edu	37	11	49208288	49208288	+	Missense_Mutation	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr11:49208288C>T	ENST00000340334.7	-	6	870	c.502G>A	c.(502-504)Gaa>Aaa	p.E168K	FOLH1_ENST00000343844.4_5'UTR|FOLH1_ENST00000356696.3_Missense_Mutation_p.E183K|FOLH1_ENST00000256999.2_Missense_Mutation_p.E183K|FOLH1_ENST00000533034.1_Missense_Mutation_p.E168K	NM_001193471.1|NM_001193472.1	NP_001180400.1|NP_001180401.1	Q04609	FOLH1_HUMAN	folate hydrolase (prostate-specific membrane antigen) 1	183					proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(34)|ovary(1)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	60					Capromab(DB00089)|L-Glutamic Acid(DB00142)	AAGAAGTCTTCAGTTCGTGCA	0.383000													14	118					0	0	1	0	0
BAIAP2	10458	broad.mit.edu	37	17	79078365	79078365	+	Missense_Mutation	SNP	G	G	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr17:79078365G>A	ENST00000321300.6	+	10	1211	c.1118G>A	c.(1117-1119)cGc>cAc	p.R373H	BAIAP2_ENST00000321280.7_Missense_Mutation_p.R373H|BAIAP2_ENST00000575245.1_Missense_Mutation_p.R406H|BAIAP2_ENST00000435091.3_Missense_Mutation_p.R373H|BAIAP2_ENST00000392411.3_Missense_Mutation_p.R295H|BAIAP2_ENST00000416299.2_Missense_Mutation_p.R236H|BAIAP2_ENST00000575712.1_Missense_Mutation_p.R373H|BAIAP2_ENST00000428708.2_Missense_Mutation_p.R373H	NM_001144888.1|NM_017451.2	NP_001138360.1|NP_059345.1	Q9UQB8	BAIP2_HUMAN	BAI1-associated protein 2	373					axonogenesis|filopodium assembly|insulin receptor signaling pathway|regulation of actin cytoskeleton organization|response to bacterium	cell junction|cytoskeleton|cytosol|filopodium|nucleus|ruffle	cytoskeletal adaptor activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(6)|skin(1)	18	all_neural(118;0.101)		BRCA - Breast invasive adenocarcinoma(99;0.0228)|OV - Ovarian serous cystadenocarcinoma(97;0.0524)			GGCCTGGAGCGCAATGGCCGT	0.642000													4	97					0	0	1	0	0
SCRIB	23513	broad.mit.edu	37	8	144893330	144893330	+	Silent	SNP	G	G	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr8:144893330G>A	ENST00000356994.2	-	10	1098	c.1092C>T	c.(1090-1092)gaC>gaT	p.D364D	SCRIB_ENST00000377533.3_Silent_p.D283D|SCRIB_ENST00000320476.3_Silent_p.D364D	NM_182706.4	NP_874365.3	Q14160	SCRIB_HUMAN	scribbled planar cell polarity protein	364	Sufficient for targeting to adherens junction and to inhibit cell proliferation.				activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(20)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	42	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			TCCCCGCCACGTCCAGCACGT	0.701000													4	30					0	0	1	0	0
MCM3AP	8888	broad.mit.edu	37	21	47660846	47660846	+	Missense_Mutation	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr21:47660846C>T	ENST00000397708.1	-	27	5766	c.5512G>A	c.(5512-5514)Gag>Aag	p.E1838K	MCM3AP-AS1_ENST00000591223.1_RNA|MCM3AP-AS1_ENST00000421927.1_RNA|MCM3AP_ENST00000467026.1_5'UTR|MCM3AP-AS1_ENST00000455567.1_RNA|MCM3AP_ENST00000291688.1_Missense_Mutation_p.E1838K|MCM3AP-AS1_ENST00000432735.1_RNA|MCM3AP-AS1_ENST00000590829.1_RNA|MCM3AP-AS1_ENST00000588753.1_RNA|MCM3AP-AS1_ENST00000444998.1_RNA|MCM3AP-AS1_ENST00000414659.1_RNA			O60318	MCM3A_HUMAN	minichromosome maintenance complex component 3 associated protein	1838					DNA replication|protein import into nucleus	cytosol|nucleus	DNA binding|nucleotide binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(10)|kidney(5)|large_intestine(17)|lung(24)|ovary(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	72	Breast(49;0.112)					TGAGCACACTCTGTGCTCCTC	0.493000													21	98					0	0	1	0	0
FOXK1	221937	broad.mit.edu	37	7	4796636	4796636	+	Silent	SNP	G	G	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr7:4796636G>A	ENST00000328914.4	+	5	1062	c.1062G>A	c.(1060-1062)cgG>cgA	p.R354R	FOXK1_ENST00000446823.1_Silent_p.R191R	NM_001037165.1	NP_001032242.1	P85037	FOXK1_HUMAN	forkhead box K1	354					cell differentiation|embryo development|muscle organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|magnesium ion binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(7)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	29		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;7.43e-15)		ATTCTATCCGGCACAACCTCT	0.522000													4	117					0	0	1	0	0
SCIN	85477	broad.mit.edu	37	7	12675695	12675695	+	Missense_Mutation	SNP	G	G	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr7:12675695G>A	ENST00000297029.5	+	10	1446	c.1345G>A	c.(1345-1347)Gag>Aag	p.E449K	SCIN_ENST00000519209.1_Missense_Mutation_p.E202K|SCIN_ENST00000445618.2_Missense_Mutation_p.E202K	NM_001112706.2	NP_001106177.1	Q9Y6U3	ADSV_HUMAN	scinderin	449	Ca(2+)-dependent actin binding.				actin filament capping|actin filament severing|actin nucleation|calcium ion-dependent exocytosis|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of megakaryocyte differentiation|positive regulation of secretion|regulation of chondrocyte differentiation	cell cortex|cytoskeleton	1-phosphatidylinositol binding|actin filament binding|calcium ion binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding			endometrium(3)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)	17				UCEC - Uterine corpus endometrioid carcinoma (126;0.195)		CACACGAGATGAGCTGACAAC	0.463000													5	21					0	0	1	0	0
TECTA	7007	broad.mit.edu	37	11	120979946	120979946	+	Missense_Mutation	SNP	C	C	G			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr11:120979946C>G	ENST00000392793.1	+	4	496	c.225C>G	c.(223-225)ttC>ttG	p.F75L	TECTA_ENST00000264037.2_Missense_Mutation_p.F75L			O75443	TECTA_HUMAN	tectorin alpha	75					cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		TTGTTTCCTTCAATGTGCTAG	0.468000													5	41					0	0	1	0	0
TSNARE1	203062	broad.mit.edu	37	8	143399953	143399953	+	Silent	SNP	G	G	A	rs144275934		TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr8:143399953G>A	ENST00000519651.1	-	5	382	c.279C>T	c.(277-279)agC>agT	p.S93S	TSNARE1_ENST00000307180.3_Silent_p.S312S|TSNARE1_ENST00000518928.1_5'UTR|TSNARE1_ENST00000524325.1_Silent_p.S312S|TSNARE1_ENST00000520166.1_Silent_p.S312S			Q96NA8	TSNA1_HUMAN	t-SNARE domain containing 1	312					vesicle-mediated transport	integral to membrane				breast(1)|endometrium(3)|kidney(4)|large_intestine(1)|lung(6)|ovary(2)|stomach(2)|urinary_tract(1)	20	all_cancers(97;7.39e-11)|all_epithelial(106;8.98e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000332)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					CGGAGCTGGCGCTGGCTGCAA	0.657000													21	168					0	0	1	0	0
CAPN13	92291	broad.mit.edu	37	2	30965219	30965219	+	Silent	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr2:30965219C>T	ENST00000295055.8	-	14	1628	c.1452G>A	c.(1450-1452)ctG>ctA	p.L484L	CAPN13_ENST00000534090.2_Silent_p.L484L	NM_144575.2	NP_653176.2	Q6MZZ7	CAN13_HUMAN	calpain 13	484					proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(1)	30	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.155)					AATGGCTGCTCAGGTGCCTAG	0.537000													3	17					0	0	1	0	0
AXIN1	8312	broad.mit.edu	37	16	347826	347826	+	Silent	SNP	G	G	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr16:347826G>A	ENST00000262320.3	-	6	2051	c.1680C>T	c.(1678-1680)agC>agT	p.S560S	AXIN1_ENST00000354866.3_Silent_p.S560S	NM_003502.3	NP_003493.1	O15169	AXIN1_HUMAN	axin 1	560	Interaction with RNF111.				activation of JUN kinase activity|activation of protein kinase activity|apoptosis|axial mesoderm formation|canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation|cellular protein complex assembly|cellular response to organic cyclic compound|cytoplasmic microtubule organization|determination of left/right symmetry|dorsal/ventral axis specification|embryonic eye morphogenesis|embryonic skeletal joint morphogenesis|forebrain anterior/posterior pattern formation|muscle cell development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fat cell differentiation|olfactory placode formation|optic placode formation|positive regulation of JNK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of transcription, DNA-dependent|positive regulation of ubiquitin-protein ligase activity|regulation of catenin import into nucleus|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuron fate commitment|Wnt receptor signaling pathway involved in somitogenesis	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|cell cortex|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|cytosol|lateral plasma membrane|nucleus|perinuclear region of cytoplasm|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|I-SMAD binding|p53 binding|protein complex scaffold|protein homodimerization activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			biliary_tract(27)|breast(4)|central_nervous_system(6)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(20)|liver(81)|lung(5)|ovary(2)|prostate(3)|salivary_gland(7)|skin(5)|stomach(4)|thyroid(41)|upper_aerodigestive_tract(4)|urinary_tract(2)	221		all_cancers(16;2.75e-07)|all_epithelial(16;1.6e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00774)|all_lung(18;0.0187)				AGGCGAAGCTGCTCTGGGCCC	0.701000													6	25					0	0	1	0	0
PPP1R32	220004	broad.mit.edu	37	11	61254049	61254049	+	Silent	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr11:61254049C>T	ENST00000338608.2	+	9	926	c.801C>T	c.(799-801)ttC>ttT	p.F267F	PPP1R32_ENST00000432063.2_Silent_p.F247F	NM_145017.2	NP_659454.2	Q7Z5V6	CK066_HUMAN	protein phosphatase 1, regulatory subunit 32	267																	AAACAGCCTTCAGCCGAGGGA	0.582000													8	29					0	0	1	0	0
USP6NL	9712	broad.mit.edu	37	10	11531113	11531113	+	Missense_Mutation	SNP	G	G	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr10:11531113G>T	ENST00000379237.1	-	10	1046	c.652C>A	c.(652-654)Cat>Aat	p.H218N	USP6NL_ENST00000277575.5_Missense_Mutation_p.H235N	NM_014688.2	NP_055503.1	Q92738	US6NL_HUMAN	USP6 N-terminal like	218	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			endometrium(3)|kidney(2)|large_intestine(6)|lung(18)|prostate(1)|skin(1)|urinary_tract(1)	32						TGCATGGCATGTTTAGGGCCT	0.423000													22	105					3.5997e-14	4.02319e-14	1	1	0
NRP2	8828	broad.mit.edu	37	2	206608171	206608171	+	Missense_Mutation	SNP	C	C	G			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr2:206608171C>G	ENST00000360409.3	+	9	2327	c.1536C>G	c.(1534-1536)atC>atG	p.I512M	NRP2_ENST00000540841.1_Missense_Mutation_p.I512M|NRP2_ENST00000417189.1_Missense_Mutation_p.I512M|NRP2_ENST00000357118.4_Missense_Mutation_p.I512M|NRP2_ENST00000272849.3_Missense_Mutation_p.I512M|NRP2_ENST00000357785.5_Missense_Mutation_p.I512M|NRP2_ENST00000355117.4_Missense_Mutation_p.I512M|NRP2_ENST00000412873.2_Missense_Mutation_p.I512M|NRP2_ENST00000540178.1_Missense_Mutation_p.I512M	NM_003872.2|NM_201266.1|NM_201279.1	NP_003863.2|NP_957718.1|NP_958436.1	O60462	NRP2_HUMAN	neuropilin 2	512	F5/8 type C 2.				angiogenesis|axon guidance|cell adhesion	integral to membrane|membrane fraction|plasma membrane	heparin binding|metal ion binding|semaphorin receptor activity|vascular endothelial growth factor receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(14)|lung(19)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	52						GAGACAGTATCACTGCTGTGG	0.567000													3	63					0	0	1	0	0
ARL8A	127829	broad.mit.edu	37	1	202104633	202104633	+	Nonsense_Mutation	SNP	G	G	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr1:202104633G>A	ENST00000272217.2	-	5	562	c.394C>T	c.(394-396)Cga>Tga	p.R132*	ARL8A_ENST00000486225.1_5'UTR	NM_001256129.1|NM_138795.3	NP_001243058.1|NP_620150.1	Q96BM9	ARL8A_HUMAN	ADP-ribosylation factor-like 8A	132					cell division|chromosome segregation|mitosis|small GTPase mediated signal transduction	late endosome membrane|lysosomal membrane|midbody|spindle midzone	alpha-tubulin binding|beta-tubulin binding|GTP binding|GTPase activity			large_intestine(1)|lung(2)|ovary(2)|skin(1)	6						GGAAGGTCTCGCTTGTTACCC	0.547000											OREG0012976	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	166					0	0	1	0	0
CELA3A	10136	broad.mit.edu	37	1	22332274	22332274	+	Missense_Mutation	SNP	C	C	T	rs147890009		TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr1:22332274C>T	ENST00000290122.3	+	4	366	c.347C>T	c.(346-348)tCg>tTg	p.S116L	CELA3A_ENST00000374663.1_Missense_Mutation_p.S116L	NM_005747.4	NP_005738.4			chymotrypsin-like elastase family, member 3A											endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						TGGAACCGCTCGTGTGTGGCC	0.582000													20	128					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105420866	105420866	+	Missense_Mutation	SNP	G	G	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr14:105420866G>A	ENST00000333244.5	-	7	1041	c.922C>T	c.(922-924)Cgc>Tgc	p.R308C		NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	308						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TGCTCTTGGCGCTCCACCGTG	0.622000													10	17					0	0	1	0	0
MAGT1	84061	broad.mit.edu	37	X	77130965	77130965	+	Missense_Mutation	SNP	A	A	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chrX:77130965A>T	ENST00000358075.6	-	2	414	c.328T>A	c.(328-330)Ttc>Atc	p.F110I	MAGT1_ENST00000373336.3_Missense_Mutation_p.F78I	NM_032121.5	NP_115497.4	Q9H0U3	MAGT1_HUMAN	magnesium transporter 1	78					protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex				cervix(1)|kidney(2)|large_intestine(3)|lung(9)|prostate(1)|upper_aerodigestive_tract(1)	17						AGAGCAGTGAACATGACGATA	0.398000													46	336					0	0	1	0	0
SERPINH1	871	broad.mit.edu	37	11	75277979	75277979	+	Silent	SNP	G	G	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr11:75277979G>A	ENST00000524558.1	+	2	2020	c.585G>A	c.(583-585)acG>acA	p.T195T	SERPINH1_ENST00000533603.1_Silent_p.T195T|SERPINH1_ENST00000358171.3_Silent_p.T195T|SERPINH1_ENST00000530284.1_Silent_p.T195T			P50454	SERPH_HUMAN	serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)	195					regulation of proteolysis|response to unfolded protein	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	collagen binding|serine-type endopeptidase inhibitor activity			endometrium(4)|large_intestine(3)|liver(1)|lung(4)|ovary(2)|stomach(1)	15	Ovarian(111;0.11)					TGGAGCGCACGGACGGCGCCC	0.662000													9	47					0	0	1	0	0
PACS2	23241	broad.mit.edu	37	14	105848855	105848855	+	Silent	SNP	C	C	G			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr14:105848855C>G	ENST00000447393.1	+	14	1630	c.1455C>G	c.(1453-1455)ctC>ctG	p.L485L	PACS2_ENST00000325438.8_Silent_p.L481L|PACS2_ENST00000547217.1_Silent_p.L451L|PACS2_ENST00000430725.2_Silent_p.L406L|PACS2_ENST00000458164.2_Silent_p.L485L	NM_015197.3	NP_056012.2	Q86VP3	PACS2_HUMAN	phosphofurin acidic cluster sorting protein 2	481					apoptosis|interspecies interaction between organisms	endoplasmic reticulum lumen|mitochondrion				endometrium(2)|kidney(2)|lung(7)|ovary(3)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	21		all_cancers(154;0.0351)|all_epithelial(191;0.153)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.0145)|Epithelial(46;0.036)	Epithelial(152;0.138)		ACCACATCCTCATCTCCGATG	0.587000													42	221					0	0	1	0	0
ECEL1	9427	broad.mit.edu	37	2	233349770	233349770	+	Missense_Mutation	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr2:233349770C>T	ENST00000304546.1	-	4	1097	c.887G>A	c.(886-888)cGa>cAa	p.R296Q	ECEL1_ENST00000409941.1_Missense_Mutation_p.R296Q	NM_004826.2	NP_004817.2	O95672	ECEL1_HUMAN	endothelin converting enzyme-like 1	296					neuropeptide signaling pathway|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity	p.R296Q(1)		breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000771)|Lung(119;0.00213)|LUSC - Lung squamous cell carcinoma(224;0.00746)		GCTGAGCACTCGCTCCATGAA	0.642000													22	43					0	0	1	0	0
REG3G	130120	broad.mit.edu	37	2	79253241	79253241	+	Missense_Mutation	SNP	C	C	G			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr2:79253241C>G	ENST00000272324.5	+	2	206	c.22C>G	c.(22-24)Ccc>Gcc	p.P8A	REG3G_ENST00000409471.1_Missense_Mutation_p.P8A|REG3G_ENST00000393897.2_Missense_Mutation_p.P8A	NM_001008387.2	NP_001008388.1	Q6UW15	REG3G_HUMAN	regenerating islet-derived 3 gamma	8					acute-phase response	extracellular region	sugar binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(27)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						CATGGCCCTGCCCAGTGTGTC	0.547000													8	49					0	0	1	0	0
EMX2	2018	broad.mit.edu	37	10	119303089	119303089	+	Missense_Mutation	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr10:119303089C>T	ENST00000553456.3	+	1	1135	c.311C>T	c.(310-312)tCg>tTg	p.S104L	EMX2OS_ENST00000551288.1_RNA|EMX2_ENST00000442245.4_Missense_Mutation_p.S104L	NM_004098.3	NP_004089.1	Q04743	EMX2_HUMAN	empty spiracles homeobox 2	104				S -> P (in Ref. 3; BAB70842).		nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(5)|lung(2)|ovary(1)|prostate(2)	12		Colorectal(252;0.109)|Lung NSC(174;0.179)|all_lung(145;0.22)		all cancers(201;0.0133)		TCCTCGCACTCGCCACACCCC	0.701000													7	79					0	0	1	0	0
IGHV4-39	28394	broad.mit.edu	37	14	106878021	106878021	+	RNA	SNP	G	G	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr14:106878021G>T	ENST00000390619.2	-	0	105																											TCTGGGAGCCGCCACCAGCAG	0.502000													13	45					7.03913e-09	7.62572e-09	1	1	0
TCP11L2	255394	broad.mit.edu	37	12	106740092	106740092	+	Missense_Mutation	SNP	G	G	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr12:106740092G>T	ENST00000299045.3	+	10	1518	c.1344G>T	c.(1342-1344)agG>agT	p.R448S		NM_152772.1	NP_689985.1	Q8N4U5	T11L2_HUMAN	t-complex 11, testis-specific-like 2	448										endometrium(2)|kidney(2)|large_intestine(5)|ovary(3)|prostate(1)|urinary_tract(2)	15						ACATGAGAAGGCTACTTTGTC	0.383000													16	46					9.16793e-09	9.88855e-09	1	1	0
TP53	7157	broad.mit.edu	37	17	7578275	7578275	+	Nonsense_Mutation	SNP	G	G	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr17:7578275G>A	ENST00000420246.2	-	6	706	c.574C>T	c.(574-576)Cag>Tag	p.Q192*	TP53_ENST00000413465.2_Nonsense_Mutation_p.Q192*|TP53_ENST00000445888.2_Nonsense_Mutation_p.Q192*|TP53_ENST00000574684.1_Intron|TP53_ENST00000269305.4_Nonsense_Mutation_p.Q192*|TP53_ENST00000359597.4_Nonsense_Mutation_p.Q192*|TP53_ENST00000455263.2_Nonsense_Mutation_p.Q192*	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	192	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		Q -> H (in sporadic cancers; somatic mutation).|Q -> K (in a sporadic cancer; somatic mutation).|Q -> L (in sporadic cancers; somatic mutation).|Q -> P (in sporadic cancers; somatic mutation).|Q -> R (in sporadic cancers; somatic mutation).|QH -> HN (in a sporadic cancer; somatic mutation).|QH -> HY (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Q192*(83)|p.0?(8)|p.Q99*(6)|p.?(6)|p.Q60*(6)|p.P191del(4)|p.P191delP(4)|p.A189_V197delAPPQHLIRV(4)|p.P191_E198>Q(3)|p.P191fs*53(2)|p.G187fs*16(2)|p.P59delP(2)|p.P98delP(2)|p.P191fs*6(1)|p.A189_Q192>E(1)|p.P59_E66>Q(1)|p.P191fs*15(1)|p.P191_Q192delPQ(1)|p.Q192K(1)|p.P98_E105>Q(1)|p.A189fs*53(1)|p.Q192del(1)|p.Q192fs*16(1)|p.L188_P191del(1)|p.Q192fs*30(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATAAGATGCTGAGGAGGGGCC	0.557000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			18	35					0	0	1	0	0
KLF17	128209	broad.mit.edu	37	1	44595051	44595051	+	Missense_Mutation	SNP	G	G	C			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr1:44595051G>C	ENST00000372299.3	+	2	166	c.108G>C	c.(106-108)ttG>ttC	p.L36F	KLF17_ENST00000476802.1_3'UTR	NM_173484.3	NP_775755.3	Q5JT82	KLF17_HUMAN	Kruppel-like factor 17	36					regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|large_intestine(1)|lung(6)|ovary(3)|prostate(1)|skin(2)|stomach(1)	18	Acute lymphoblastic leukemia(166;0.155)					CGCCCATCTTGAACATGTCTT	0.502000													47	73					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	106960935	106960935	+	Nonsense_Mutation	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr10:106960935C>T	ENST00000369701.3	+	16	2412	c.2185C>T	c.(2185-2187)Cag>Tag	p.Q729*	SORCS3_ENST00000369699.4_Nonsense_Mutation_p.Q15*	NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	729						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		GCCAGGAGCTCAGTGTGCCCT	0.468000													21	94					0	0	1	0	0
NFE2L3	9603	broad.mit.edu	37	7	26223354	26223354	+	Missense_Mutation	SNP	C	C	G			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr7:26223354C>G	ENST00000056233.3	+	3	1043	c.784C>G	c.(784-786)Ctg>Gtg	p.L262V		NM_004289.6	NP_004280.5	Q9Y4A8	NF2L3_HUMAN	nuclear factor, erythroid 2-like 3	262					transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)|skin(5)|urinary_tract(7)	29						TTCTTTCTCTCTGGAAGACTT	0.413000													16	111					0	0	1	0	0
IL1RAPL1	11141	broad.mit.edu	37	X	29973740	29973740	+	Missense_Mutation	SNP	G	G	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chrX:29973740G>A	ENST00000378993.1	+	11	2567	c.1894G>A	c.(1894-1896)Gta>Ata	p.V632I	IL1RAPL1_ENST00000302196.4_Missense_Mutation_p.V632I	NM_014271.3	NP_055086.1	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	632	Interaction with NCS1.				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			biliary_tract(1)|breast(1)|endometrium(5)|large_intestine(9)|lung(38)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62						TGAGTACGACGTACCTCCTAC	0.507000													10	22					0	0	1	0	0
RPL32	6161	broad.mit.edu	37	3	12881680	12881680	+	Silent	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr3:12881680C>T	ENST00000429711.2	-	2	156	c.57G>A	c.(55-57)aaG>aaA	p.K19K	RPL32_ENST00000396953.2_Silent_p.K19K|RPL32_ENST00000273223.6_Silent_p.K19K|RPL32_ENST00000396957.1_Silent_p.K19K|RPL32_ENST00000435983.1_Silent_p.K19K	NM_000994.3	NP_000985.1	P62910	RL32_HUMAN	ribosomal protein L32	19					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|ribosome	protein binding|structural constituent of ribosome			kidney(1)|large_intestine(2)|lung(2)|ovary(1)	6						GCCGGATGAACTTCTTGGTTC	0.502000													84	242					0	0	1	0	0
DOCK1	1793	broad.mit.edu	37	10	129046280	129046280	+	Silent	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr10:129046280C>T	ENST00000280333.6	+	28	2902	c.2793C>T	c.(2791-2793)ttC>ttT	p.F931F	DOCK1_ENST00000484400.1_3'UTR	NM_001380.3	NP_001371.1	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	931					apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding	p.F931F(1)		NS(2)|breast(1)|central_nervous_system(7)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(10)|lung(15)|ovary(4)|prostate(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	72		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		AGGGAAACTTCGTGGCTTGCA	0.403000													7	28					0	0	1	0	0
HIST2H2BE	8349	broad.mit.edu	37	1	149857978	149857978	+	Missense_Mutation	SNP	G	G	C			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr1:149857978G>C	ENST00000369155.2	-	1	254	c.213C>G	c.(211-213)ttC>ttG	p.F71L		NM_003528.2	NP_003519.1	Q16778	H2B2E_HUMAN	histone cluster 2, H2be	71					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding	p.F71L(1)		breast(1)|haematopoietic_and_lymphoid_tissue(1)|lung(9)|ovary(2)|upper_aerodigestive_tract(1)	14	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			CGATGCGCTCGAAGATGTCGT	0.622000													27	183					0	0	1	0	0
MTBP	27085	broad.mit.edu	37	8	121535550	121535550	+	Missense_Mutation	SNP	G	G	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr8:121535550G>T	ENST00000305949.1	+	22	2734	c.2689G>T	c.(2689-2691)Gta>Tta	p.V897L		NM_022045.3	NP_071328.2	Q96DY7	MTBP_HUMAN	Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa	897	Interaction with MDM2 (By similarity).				cell cycle arrest					NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	30	Lung NSC(37;5.68e-08)|Ovarian(258;0.00769)|all_neural(195;0.0804)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00503)			GATTGACTGGGTATTAGAAAA	0.279000													5	312					0.00116845	0.00118768	1	1	0
SMCHD1	23347	broad.mit.edu	37	18	2688459	2688459	+	Missense_Mutation	SNP	G	G	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr18:2688459G>T	ENST00000320876.6	+	6	1044	c.706G>T	c.(706-708)Ggt>Tgt	p.G236C	SMCHD1_ENST00000261598.8_Missense_Mutation_p.G236C	NM_015295.2	NP_056110.2	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible hinge domain containing 1	236					chromosome organization		ATP binding			NS(3)|breast(3)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(16)|lung(15)|pancreas(1)	45						TTCCTATTTTGGTGTTGGGGG	0.338000													14	142					2.23348e-06	2.36768e-06	1	1	0
TESK1	7016	broad.mit.edu	37	9	35608973	35608973	+	Missense_Mutation	SNP	G	G	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr9:35608973G>A	ENST00000336395.5	+	10	1365	c.1115G>A	c.(1114-1116)gGg>gAg	p.G372E	TESK1_ENST00000498522.1_3'UTR	NM_006285.2	NP_006276.2	Q15569	TESK1_HUMAN	testis-specific kinase 1	372					cell junction assembly|spermatogenesis	cytosol	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	27			Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			CCCAACTGGGGGGACAATCTG	0.612000													22	109					0	0	1	0	0
SPI1	6688	broad.mit.edu	37	11	47399866	47399866	+	Silent	SNP	G	G	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr11:47399866G>T	ENST00000378538.3	-	1	261	c.39C>A	c.(37-39)gtC>gtA	p.V13V	SPI1_ENST00000533030.1_Silent_p.V13V|SPI1_ENST00000533968.1_Silent_p.V13V|SPI1_ENST00000227163.4_Silent_p.V13V	NM_001080547.1|NM_003120.2	NP_001074016.1|NP_003111.2	P17947	SPI1_HUMAN	spleen focus forming virus (SFFV) proviral integration oncogene	13					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of erythrocyte differentiation	nucleus	protein binding|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|large_intestine(2)|lung(4)|ovary(1)	8				Lung(87;0.0967)		TCACAGGGGGGACGAGGGGAA	0.682000													4	12					1.23904e-05	1.30788e-05	1	1	0
MCM8	84515	broad.mit.edu	37	20	5948594	5948594	+	Missense_Mutation	SNP	G	G	C			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr20:5948594G>C	ENST00000378896.3	+	10	1523	c.1146G>C	c.(1144-1146)ttG>ttC	p.L382F	MCM8_ENST00000265187.4_Missense_Mutation_p.L366F|MCM8_ENST00000378886.2_Missense_Mutation_p.L382F|MCM8_ENST00000378883.1_Missense_Mutation_p.L382F	NM_032485.4|NM_182802.1	NP_115874.3|NP_877954.1	Q9UJA3	MCM8_HUMAN	minichromosome maintenance complex component 8	382					cell cycle checkpoint|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|nucleoside-triphosphatase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	23						ATGGAATGTTGATGGAGTTCT	0.348000													16	128					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179424238	179424238	+	Missense_Mutation	SNP	C	C	G			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr2:179424238C>G	ENST00000589042.1	-	326	86845	c.86621G>C	c.(86620-86622)gGa>gCa	p.G28874A	TTN_ENST00000342175.6_Missense_Mutation_p.G20001A|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.G27233A|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.G19809A|TTN_ENST00000359218.5_Missense_Mutation_p.G19934A|TTN-AS1_ENST00000438095.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.G26306A	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	27233	Fibronectin type-III 110.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CACTGGTGCTCCACCATCGTT	0.458000													13	107					0	0	1	0	0
KRT2	3849	broad.mit.edu	37	12	53044254	53044254	+	Silent	SNP	G	G	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr12:53044254G>T	ENST00000309680.3	-	2	690	c.669C>A	c.(667-669)atC>atA	p.I223I		NM_000423.2	NP_000414.2	P35908	K22E_HUMAN	keratin 2	223	Linker 1.|Rod.				keratinization|keratinocyte activation|keratinocyte migration|keratinocyte proliferation	Golgi apparatus|keratin filament	protein binding|structural constituent of cytoskeleton			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(18)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	32				BRCA - Breast invasive adenocarcinoma(357;0.19)		GCTCCAGGTTGATGGGGCGGG	0.507000													24	210					6.36457e-07	6.80541e-07	1	1	0
SETDB2	83852	broad.mit.edu	37	13	50062507	50062507	+	Missense_Mutation	SNP	G	G	C			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr13:50062507G>C	ENST00000354234.4	+	12	2564	c.1658G>C	c.(1657-1659)aGa>aCa	p.R553T	SETDB2_ENST00000317257.8_Missense_Mutation_p.R565T	NM_001160308.1	NP_001153780.1	Q96T68	SETB2_HUMAN	SET domain, bifurcated 2	565	SET.				cell division|chromosome segregation|heart looping|left/right axis specification|mitosis|negative regulation of transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone methyltransferase activity (H3-K9 specific)|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	15		Lung NSC(96;0.000408)|Breast(56;0.00131)|Prostate(109;0.00446)|Hepatocellular(98;0.0556)|Glioma(44;0.236)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;3.1e-09)		ACTAAATATAGAGAAGAAACT	0.363000													24	125					0	0	1	0	0
SPOPL	339745	broad.mit.edu	37	2	139316854	139316854	+	Missense_Mutation	SNP	C	C	G			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr2:139316854C>G	ENST00000280098.4	+	7	1040	c.661C>G	c.(661-663)Cga>Gga	p.R221G		NM_001001664.2	NP_001001664.1	Q6IQ16	SPOPL_HUMAN	speckle-type POZ protein-like	221	BTB.					nucleus				breast(2)|cervix(2)|endometrium(2)|large_intestine(2)|lung(11)|skin(2)	21				BRCA - Breast invasive adenocarcinoma(221;0.0296)		TGTTACAGCTCGATCTCCAGT	0.299000													11	42					0	0	1	0	0
NLRP3	114548	broad.mit.edu	37	1	247587769	247587769	+	Missense_Mutation	SNP	C	C	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr1:247587769C>A	ENST00000366497.2	+	4	1804	c.1024C>A	c.(1024-1026)Ccc>Acc	p.P342T	NLRP3_ENST00000391827.2_Missense_Mutation_p.P342T|NLRP3_ENST00000391828.3_Missense_Mutation_p.P342T|NLRP3_ENST00000474792.1_3'UTR|NLRP3_ENST00000336119.3_Missense_Mutation_p.P342T|NLRP3_ENST00000348069.2_Missense_Mutation_p.P342T|NLRP3_ENST00000366496.2_Missense_Mutation_p.P342T	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	342	NACHT.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			GAAGCTGCTTCCCGAGGCCTC	0.587000													39	66					4.01765e-15	4.51073e-15	1	1	0
SLC4A7	9497	broad.mit.edu	37	3	27439195	27439195	+	Missense_Mutation	SNP	G	G	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr3:27439195G>T	ENST00000295736.5	-	18	2726	c.2656C>A	c.(2656-2658)Cat>Aat	p.H886N	SLC4A7_ENST00000425128.2_3'UTR|SLC4A7_ENST00000445684.1_Missense_Mutation_p.H882N|SLC4A7_ENST00000446700.1_Missense_Mutation_p.H878N|SLC4A7_ENST00000428386.1_Missense_Mutation_p.H762N|SLC4A7_ENST00000454389.1_Missense_Mutation_p.H895N|SLC4A7_ENST00000435667.2_Missense_Mutation_p.H771N|SLC4A7_ENST00000455077.1_Missense_Mutation_p.H767N|SLC4A7_ENST00000437179.1_Missense_Mutation_p.H767N|SLC4A7_ENST00000440156.1_Missense_Mutation_p.H882N|SLC4A7_ENST00000388777.4_Missense_Mutation_p.H436N	NM_003615.4	NP_003606.3	Q9Y6M7	S4A7_HUMAN	solute carrier family 4, sodium bicarbonate cotransporter, member 7	886						apical plasma membrane|basolateral plasma membrane|integral to membrane|stereocilium	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			NS(2)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(12)|lung(9)|ovary(4)|skin(1)	38						TCAGGAACATGAAGTTTAGGA	0.343000													5	27					0.184627	0.184627	1	1	0
ADAM12	8038	broad.mit.edu	37	10	127782640	127782640	+	Silent	SNP	G	G	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr10:127782640G>A	ENST00000368679.4	-	11	1377	c.1068C>T	c.(1066-1068)ttC>ttT	p.F356F	ADAM12_ENST00000368676.4_Silent_p.F356F	NM_003474.4	NP_003465.3	O43184	ADA12_HUMAN	ADAM metallopeptidase domain 12	356	Peptidase M12B.				cell adhesion|epidermal growth factor receptor signaling pathway|myoblast fusion|proteolysis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|protein binding|SH3 domain binding|zinc ion binding	p.F356F(3)		biliary_tract(1)|breast(7)|central_nervous_system(4)|endometrium(5)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	69		all_epithelial(44;7.06e-05)|all_lung(145;0.00563)|Lung NSC(174;0.00834)|Colorectal(57;0.102)|all_neural(114;0.107)|Breast(234;0.22)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.216)		GATTCATCCCGAAATTGTGGC	0.502000													17	63					0	0	1	0	0
CDCA2	157313	broad.mit.edu	37	8	25344843	25344843	+	Missense_Mutation	SNP	G	G	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr8:25344843G>T	ENST00000330560.3	+	12	2003	c.1526G>T	c.(1525-1527)aGa>aTa	p.R509I	CDCA2_ENST00000521098.2_3'UTR|CDCA2_ENST00000380665.3_Missense_Mutation_p.R494I	NM_152562.2	NP_689775.2	Q69YH5	CDCA2_HUMAN	cell division cycle associated 2	509					cell division|mitosis	cytoplasm|nucleus				breast(3)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(7)|lung(10)|ovary(1)|prostate(3)	35		all_cancers(63;0.0378)|Ovarian(32;0.000878)|all_epithelial(46;0.0162)|Breast(100;0.0164)|Prostate(55;0.191)		UCEC - Uterine corpus endometrioid carcinoma (27;0.022)|Epithelial(17;1.37e-11)|Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0443)		ACTTCTAACAGAAGAAATGTA	0.328000													23	112					1.85244e-09	2.01565e-09	1	1	0
MTMR14	64419	broad.mit.edu	37	3	9695317	9695317	+	Missense_Mutation	SNP	G	G	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr3:9695317G>A	ENST00000296003.4	+	2	294	c.172G>A	c.(172-174)Gag>Aag	p.E58K	MTMR14_ENST00000353332.5_Missense_Mutation_p.E58K|MTMR14_ENST00000420925.1_Intron|MTMR14_ENST00000351233.5_Missense_Mutation_p.E58K	NM_001077525.2	NP_001070993.1	Q8NCE2	MTMRE_HUMAN	myotubularin related protein 14	58						perinuclear region of cytoplasm|ruffle	phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity			breast(1)|endometrium(3)|kidney(2)|lung(10)|skin(3)|upper_aerodigestive_tract(2)	21	Medulloblastoma(99;0.227)					TGAGCGCATTGAGAAGAGATG	0.512000													6	142					0	0	1	0	0
HSPA14	51182	broad.mit.edu	37	10	14891737	14891737	+	Silent	SNP	T	T	C			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr10:14891737T>C	ENST00000378372.3	+	6	633	c.394T>C	c.(394-396)Ttg>Ctg	p.L132L		NM_016299.2	NP_057383.2	Q0VDF9	HSP7E_HUMAN	heat shock 70kDa protein 14	132					'de novo' cotranslational protein folding	cytosol	ATP binding|protein binding			breast(4)|endometrium(2)|kidney(2)|large_intestine(3)|lung(4)|ovary(2)	17						ACATTCTGTATTGGGCTCAGA	0.328000													10	63					0	0	1	0	0
HNRNPH3	3189	broad.mit.edu	37	10	70098948	70098948	+	Missense_Mutation	SNP	A	A	T	rs2273903	byFrequency	TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr10:70098948A>T	ENST00000265866.7	+	5	653	c.488A>T	c.(487-489)aAt>aTt	p.N163I	HNRNPH3_ENST00000469172.1_3'UTR|HNRNPH3_ENST00000441000.2_Missense_Mutation_p.N55I|HNRNPH3_ENST00000354695.5_Missense_Mutation_p.N148I	NM_012207.2|NM_021644.3	NP_036339.1|NP_067676.2	P31942	HNRH3_HUMAN	heterogeneous nuclear ribonucleoprotein H3 (2H9)	163	Gly-rich.		N -> S (in dbSNP:rs2273903).		nuclear mRNA splicing, via spliceosome	heterogeneous nuclear ribonucleoprotein complex	nucleotide binding|protein binding|RNA binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(5)|ovary(2)|prostate(2)	11						GGCTATGGGAATGATGGCTTT	0.328000													21	80					0	0	1	0	0
AP4E1	23431	broad.mit.edu	37	15	51294782	51294782	+	Missense_Mutation	SNP	C	C	G			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr15:51294782C>G	ENST00000261842.5	+	21	3443	c.3337C>G	c.(3337-3339)Ctg>Gtg	p.L1113V	AP4E1_ENST00000560508.1_Missense_Mutation_p.L1038V|AP4E1_ENST00000561397.1_3'UTR	NM_001252127.1|NM_007347.4	NP_001239056.1|NP_031373.2	Q9UPM8	AP4E1_HUMAN	adaptor-related protein complex 4, epsilon 1 subunit	1113					intracellular protein transport|vesicle-mediated transport	COPI vesicle coat	binding|structural molecule activity			breast(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(5)|skin(2)	27				all cancers(107;0.000893)|GBM - Glioblastoma multiforme(94;0.00364)		TGTATTAGCCCTGTGGTTCAG	0.458000													35	120					0	0	1	0	0
BIRC6	57448	broad.mit.edu	37	2	32822887	32822887	+	Missense_Mutation	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr2:32822887C>T	ENST00000421745.2	+	69	13816	c.13682C>T	c.(13681-13683)tCt>tTt	p.S4561F		NM_016252.3	NP_057336.3	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	4561					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					CACTACATGTCTCAGGTGAAA	0.428000													6	28					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577094	7577094	+	Missense_Mutation	SNP	G	G	A	rs28934574		TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr17:7577094G>A	ENST00000420246.2	-	8	976	c.844C>T	c.(844-846)Cgg>Tgg	p.R282W	TP53_ENST00000413465.2_Intron|TP53_ENST00000445888.2_Missense_Mutation_p.R282W|TP53_ENST00000269305.4_Missense_Mutation_p.R282W|TP53_ENST00000359597.4_Missense_Mutation_p.R282W|TP53_ENST00000455263.2_Missense_Mutation_p.R282W	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	282	Interaction with AXIN1 (By similarity).|Interaction with E4F1.|Interaction with HIPK1 (By similarity).		DR -> EW (in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> H (in a sporadic cancer; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> Q (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs28934574).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R282W(401)|p.R282G(29)|p.0?(8)|p.R282fs*24(4)|p.R282R(3)|p.?(2)|p.D281fs*63(2)|p.D281_R282>EW(2)|p.A276_R283delACPGRDRR(1)|p.D281_R282insXX(1)|p.C275fs*20(1)|p.R282_E287delRRTEEE(1)|p.L265_K305del41(1)|p.D281_R282delDR(1)|p.G279fs*59(1)|p.R280fs*62(1)|p.S269fs*21(1)|p.R282fs*63(1)|p.V272_K292del21(1)|p.C275_R283delCACPGRDRR(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCTGTGCGCCGGTCTCTCCCA	0.557000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			9	34					0	0	1	0	0
NFE2L3	9603	broad.mit.edu	37	7	26224177	26224177	+	Missense_Mutation	SNP	C	C	G			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr7:26224177C>G	ENST00000056233.3	+	4	1118	c.859C>G	c.(859-861)Ctt>Gtt	p.L287V		NM_004289.6	NP_004280.5	Q9Y4A8	NF2L3_HUMAN	nuclear factor, erythroid 2-like 3	287					transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)|skin(5)|urinary_tract(7)	29						AGATATTCCTCTTCCAGGCAG	0.403000													32	204					0	0	1	0	0
ZNF665	79788	broad.mit.edu	37	19	53669307	53669307	+	Missense_Mutation	SNP	G	G	C			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr19:53669307G>C	ENST00000600412.1	-	2	356	c.241C>G	c.(241-243)Cag>Gag	p.Q81E	ZNF665_ENST00000396424.3_Missense_Mutation_p.Q146E			Q9H7R5	ZN665_HUMAN	zinc finger protein 665	81					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(10)|lung(16)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	35				GBM - Glioblastoma multiforme(134;0.0196)		AGATGTGACTGAAAGCTTACT	0.378000													28	160					0	0	1	0	0
ZC3H7A	29066	broad.mit.edu	37	16	11868313	11868313	+	Missense_Mutation	SNP	G	G	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr16:11868313G>A	ENST00000396516.2	-	8	879	c.682C>T	c.(682-684)Cat>Tat	p.H228Y	ZC3H7A_ENST00000355758.4_Missense_Mutation_p.H228Y			Q8IWR0	Z3H7A_HUMAN	zinc finger CCCH-type containing 7A	228						nucleus	nucleic acid binding|zinc ion binding	p.H228Y(1)		breast(2)|endometrium(3)|kidney(5)|large_intestine(2)|liver(1)|lung(3)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(2)	25						CCAACTTCATGAGAAAAACTG	0.458000													16	79					0	0	1	0	0
PROKR1	10887	broad.mit.edu	37	2	68882334	68882334	+	Missense_Mutation	SNP	G	G	C			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr2:68882334G>C	ENST00000303786.3	+	3	1228	c.808G>C	c.(808-810)Gag>Cag	p.E270Q	PROKR1_ENST00000394342.2_Missense_Mutation_p.E270Q			Q8TCW9	PKR1_HUMAN	prokineticin receptor 1	270						integral to membrane|plasma membrane	neuropeptide Y receptor activity	p.E270K(1)		endometrium(3)|kidney(2)|large_intestine(14)|lung(9)|ovary(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						ATTCCAGACAGAGCAGATCCG	0.612000													13	69					0	0	1	0	0
IKZF1	10320	broad.mit.edu	37	7	50468225	50468225	+	Missense_Mutation	SNP	G	G	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr7:50468225G>A	ENST00000331340.3	+	8	1615	c.1460G>A	c.(1459-1461)cGt>cAt	p.R487H	IKZF1_ENST00000439701.1_Missense_Mutation_p.R445H|IKZF1_ENST00000357364.4_Missense_Mutation_p.R400H|IKZF1_ENST00000359197.5_Missense_Mutation_p.R445H|IKZF1_ENST00000343574.5_Missense_Mutation_p.R400H|IKZF1_ENST00000438033.1_Missense_Mutation_p.R400H|IKZF1_ENST00000346667.4_Missense_Mutation_p.R257H|IKZF1_ENST00000440768.2_3'UTR|IKZF1_ENST00000349824.4_Missense_Mutation_p.R344H	NM_001220769.1|NM_001220772.1|NM_001220773.1|NM_001220775.1|NM_006060.4	NP_001207698.1|NP_001207701.1|NP_001207702.1|NP_001207704.1|NP_006051.1	Q13422	IKZF1_HUMAN	IKAROS family zinc finger 1 (Ikaros)	487					cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding	p.?(28)		haematopoietic_and_lymphoid_tissue(275)|lung(1)	276	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				CACGGCTTCCGTGATCCTTTT	0.577000			"""D,T"""	BCL6	"""ALL, DLBCL"""								33	46					0	0	1	0	0
TXNDC16	57544	broad.mit.edu	37	14	52978086	52978086	+	Missense_Mutation	SNP	G	G	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr14:52978086G>A	ENST00000281741.4	-	9	999	c.628C>T	c.(628-630)Cat>Tat	p.H210Y	TXNDC16_ENST00000554399.1_Intron	NM_001160047.1|NM_020784.2	NP_001153519.1|NP_065835.2	Q9P2K2	TXD16_HUMAN	thioredoxin domain containing 16	210					cell redox homeostasis	extracellular region				breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(10)|prostate(3)|skin(1)	21	Breast(41;0.0716)					AAGTAGAGATGTGCATATTCC	0.343000													19	99					0	0	1	0	0
GOLM1	51280	broad.mit.edu	37	9	88694257	88694257	+	Splice_Site	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr9:88694257C>T	ENST00000388712.3	-	2	148		c.e2-1		GOLM1_ENST00000388711.3_Splice_Site	NM_016548.3	NP_057632.2	Q8NBJ4	GOLM1_HUMAN	golgi membrane protein 1							Golgi apparatus|integral to plasma membrane				breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|liver(1)|lung(4)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	17						CGCTGAGAATCTGCCAAGTAA	0.502000													20	57					0	0	1	0	0
ANKS1B	56899	broad.mit.edu	37	12	99640583	99640583	+	Missense_Mutation	SNP	C	C	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr12:99640583C>A	ENST00000547776.2	-	13	1815	c.1816G>T	c.(1816-1818)Gca>Tca	p.A606S	ANKS1B_ENST00000550833.1_5'UTR|ANKS1B_ENST00000329257.7_Missense_Mutation_p.A606S|ANKS1B_ENST00000547010.1_Missense_Mutation_p.A186S	NM_152788.4	NP_690001.3	Q7Z6G8	ANS1B_HUMAN	ankyrin repeat and sterile alpha motif domain containing 1B	606						Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane				NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(15)|lung(38)|pancreas(1)|prostate(2)|skin(1)	70		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		AGCAGGCCTGCAAATTGCCCA	0.453000													9	199					2.17888e-05	2.28044e-05	1	1	0
NFASC	23114	broad.mit.edu	37	1	204957855	204957855	+	Silent	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr1:204957855C>T	ENST00000367172.4	+	25	3337	c.3009C>T	c.(3007-3009)taC>taT	p.Y1003Y	NFASC_ENST00000339876.6_Silent_p.Y896Y|NFASC_ENST00000367171.4_Silent_p.Y988Y|NFASC_ENST00000404907.1_Silent_p.Y999Y|NFASC_ENST00000360049.4_Silent_p.Y999Y|NFASC_ENST00000495396.1_3'UTR|NFASC_ENST00000401399.1_Silent_p.Y896Y|NFASC_ENST00000338515.6_Silent_p.Y1003Y|NFASC_ENST00000513543.1_Silent_p.Y999Y|NFASC_ENST00000367169.4_Silent_p.Y896Y|NFASC_ENST00000367170.4_Silent_p.Y1003Y|NFASC_ENST00000539706.1_Silent_p.Y999Y|NFASC_ENST00000404076.1_Silent_p.Y982Y|NFASC_ENST00000338586.6_Silent_p.Y1003Y			O94856	NFASC_HUMAN	neurofascin	1003	Fibronectin type-III 4.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			TGTCACGCTACCGCTTTACCC	0.582000													21	76					0	0	1	0	0
FNIP1	96459	broad.mit.edu	37	5	131014771	131014771	+	Missense_Mutation	SNP	G	G	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr5:131014771G>A	ENST00000307968.7	-	11	1215	c.1216C>T	c.(1216-1218)Cgt>Tgt	p.R406C	FNIP1_ENST00000307954.8_Missense_Mutation_p.R389C|FNIP1_ENST00000514667.1_Intron|FNIP1_ENST00000511848.1_Missense_Mutation_p.R434C|FNIP1_ENST00000510461.1_Missense_Mutation_p.R434C	NM_001008738.2	NP_001008738.2			folliculin interacting protein 1									p.R434C(1)		NS(1)|breast(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(11)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34		all_cancers(142;0.00347)|Lung NSC(810;0.106)|all_lung(232;0.123)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0665)		TTCATGAAACGATAGCAAAGG	0.348000													16	54					0	0	1	0	0
NLRC5	84166	broad.mit.edu	37	16	57104531	57104531	+	Splice_Site	SNP	G	G	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr16:57104531G>A	ENST00000436936.1	+	38	4956		c.e38+1		NLRC5_ENST00000262510.6_Splice_Site|NLRC5_ENST00000539144.1_Splice_Site|NLRC5_ENST00000308149.7_Splice_Site			Q86WI3	NLRC5_HUMAN	NLR family, CARD domain containing 5						defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			NS(2)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(21)|ovary(8)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	75		all_neural(199;0.225)				AGAGGCTGGAGTAAGTAGTGA	0.532000													33	42					0	0	1	0	0
RUNX1T1	862	broad.mit.edu	37	8	93003946	93003946	+	Silent	SNP	A	A	G			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr8:93003946A>G	ENST00000523629.1	-	7	1366	c.912T>C	c.(910-912)gaT>gaC	p.D304D	RUNX1T1_ENST00000422361.2_Silent_p.D267D|RUNX1T1_ENST00000518844.1_Silent_p.D277D|RUNX1T1_ENST00000436581.2_Silent_p.D315D|RUNX1T1_ENST00000360348.2_Silent_p.D267D|RUNX1T1_ENST00000265814.3_Silent_p.D304D|RUNX1T1_ENST00000396218.1_Silent_p.D277D|RUNX1T1_ENST00000520724.1_Silent_p.D267D	NM_001198626.1|NM_001198630.1|NM_001198633.1|NM_175634.2	NP_001185555.1|NP_001185559.1|NP_001185562.1|NP_783552.1	Q06455	MTG8_HUMAN	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	304					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(54)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	86			BRCA - Breast invasive adenocarcinoma(11;0.0141)			CAATGGCCATATCATCCAAAC	0.567000													99	130					0	0	1	0	0
MAGEB1	4112	broad.mit.edu	37	X	30269282	30269282	+	Missense_Mutation	SNP	G	G	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chrX:30269282G>A	ENST00000378981.3	+	4	993	c.672G>A	c.(670-672)atG>atA	p.M224I	MAGEB1_ENST00000397548.2_Missense_Mutation_p.M224I|MAGEB1_ENST00000397550.1_Missense_Mutation_p.M224I	NM_002363.4	NP_002354.2	P43366	MAGB1_HUMAN	melanoma antigen family B, 1	224	MAGE.							p.M224I(1)		NS(2)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(8)|lung(12)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	32						GGAAATTCATGAATGTGTTGG	0.478000													14	42					0	0	1	0	0
TLR4	7099	broad.mit.edu	37	9	120476222	120476222	+	Nonsense_Mutation	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr9:120476222C>T	ENST00000355622.6	+	3	1917	c.1816C>T	c.(1816-1818)Cga>Tga	p.R606*	TLR4_ENST00000394487.4_Nonsense_Mutation_p.R566*|TLR4_ENST00000472304.1_3'UTR	NM_138554.4|NM_138557.2	NP_612564.1|NP_612567.1	O00206	TLR4_HUMAN	toll-like receptor 4	606	LRRCT.				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(66)|ovary(4)|pancreas(1)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	103						GGAAGTTGAACGAATGGAATG	0.443000													31	59					0	0	1	0	0
BDH2	56898	broad.mit.edu	37	4	104016382	104016382	+	Silent	SNP	A	A	C			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr4:104016382A>C	ENST00000296424.4	-	3	249	c.129T>G	c.(127-129)ctT>ctG	p.L43L		NM_020139.3	NP_064524.3	Q9BUT1	BDH2_HUMAN	3-hydroxybutyrate dehydrogenase, type 2	43					fatty acid beta-oxidation|heme metabolic process|iron ion homeostasis|siderophore biosynthetic process	cytoplasm	3-hydroxybutyrate dehydrogenase activity|NAD binding|oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(4)|urinary_tract(1)	10		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.02e-08)		CCAGTTCCTGAAGTTTGGACT	0.403000													21	135					0	0	1	0	0
HLA-A	3105	broad.mit.edu	37	6	29910607	29910607	+	Silent	SNP	G	G	C	rs72555397		TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr6:29910607G>C	ENST00000396634.1	+	4	488	c.147G>C	c.(145-147)gtG>gtC	p.V49V	HLA-A_ENST00000376806.5_Silent_p.V49V|HLA-A_ENST00000376802.2_Silent_p.V49V|HLA-A_ENST00000376809.5_Silent_p.V49V			P30443	1A01_HUMAN	major histocompatibility complex, class I, A	49	Alpha-1.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity	p.V49V(2)		central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	30						TCATCGCCGTGGGCTACGTGG	0.692000									Osteosarcoma, Familial Clustering of;Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of;Melanoma, Familial Clustering of;Lichen Sclerosis et Atrophicus, Familial Clustering of	Multiple Myeloma(9;0.094)			6	54					0	0	1	0	0
RPA1	6117	broad.mit.edu	37	17	1792040	1792040	+	Silent	SNP	G	G	A	rs145553070	byFrequency	TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr17:1792040G>A	ENST00000254719.5	+	14	1556	c.1446G>A	c.(1444-1446)ccG>ccA	p.P482P		NM_002945.3	NP_002936.1	P27694	RFA1_HUMAN	replication protein A1, 70kDa	482					cell cycle checkpoint|DNA recombinase assembly|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	actin cytoskeleton|cytoplasm|DNA replication factor A complex|PML body	metal ion binding|protein binding|single-stranded DNA binding			breast(1)|endometrium(3)|large_intestine(2)|lung(2)|ovary(2)	10						AAGCCTGCCCGACTCAGGACT	0.483000								Nucleotide excision repair (NER)					14	87					0	0	1	0	0
HTR3A	3359	broad.mit.edu	37	11	113857259	113857259	+	Missense_Mutation	SNP	C	C	G			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr11:113857259C>G	ENST00000504030.2	+	7	1170	c.725C>G	c.(724-726)cCc>cGc	p.P242R	HTR3A_ENST00000355556.2_Missense_Mutation_p.P248R|HTR3A_ENST00000535865.1_5'UTR|HTR3A_ENST00000506841.2_Missense_Mutation_p.P242R|HTR3A_ENST00000299961.5_Missense_Mutation_p.P227R|HTR3A_ENST00000375498.2_Missense_Mutation_p.P248R			P46098	5HT3A_HUMAN	5-hydroxytryptamine (serotonin) receptor 3A, ionotropic	242					digestion|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	serotonin binding|serotonin receptor activity|serotonin-activated cation-selective channel activity			central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(14)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	36		all_cancers(61;2.31e-17)|all_epithelial(67;2.1e-10)|all_hematologic(158;4.64e-05)|Melanoma(852;0.000312)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0294)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.71e-06)|Epithelial(105;2.58e-05)|all cancers(92;0.000238)|OV - Ovarian serous cystadenocarcinoma(223;0.191)	Alosetron(DB00969)|Chloroprocaine(DB01161)|Cisapride(DB00604)|Dolasetron(DB00757)|Granisetron(DB00889)|Mirtazapine(DB00370)|Ondansetron(DB00904)|Palonosetron(DB00377)|Procaine(DB00721)|Tubocurarine(DB01199)	CGCCGGCGGCCCCTCTTCTAT	0.612000													16	81					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152348774	152348774	+	Missense_Mutation	SNP	C	C	G			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr2:152348774C>G	ENST00000427231.2	-	178	25097	c.24895G>C	c.(24895-24897)Gag>Cag	p.E8299Q	RIF1_ENST00000457745.1_Intron|NEB_ENST00000604864.1_Missense_Mutation_p.E8299Q|NEB_ENST00000397336.2_Missense_Mutation_p.E274Q|NEB_ENST00000172853.10_Missense_Mutation_p.E6443Q|NEB_ENST00000409198.1_Missense_Mutation_p.E6443Q|NEB_ENST00000498015.2_5'UTR|NEB_ENST00000397345.3_Missense_Mutation_p.E8299Q|NEB_ENST00000509223.2_Missense_Mutation_p.E212Q|NEB_ENST00000603639.1_Missense_Mutation_p.E8299Q	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	6443					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		TTGTGTTTCTCAAAGTCTTCA	0.398000													5	78					0	0	1	0	0
STAT5A	6776	broad.mit.edu	37	17	40453383	40453383	+	Silent	SNP	G	G	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr17:40453383G>A	ENST00000345506.4	+	10	1722	c.1080G>A	c.(1078-1080)ctG>ctA	p.L360L	STAT5A_ENST00000546010.2_Silent_p.L330L|STAT5A_ENST00000590949.1_Silent_p.L360L|STAT5A_ENST00000588868.1_Silent_p.L360L|STAT5A_ENST00000452307.2_Silent_p.L360L	NM_003152.3	NP_003143.2	P42229	STA5A_HUMAN	signal transducer and activator of transcription 5A	360					2-oxoglutarate metabolic process|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|fatty acid metabolic process|isoleucine metabolic process|oxaloacetate metabolic process|succinate metabolic process|taurine metabolic process|valine metabolic process	cytosol|nucleoplasm	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|kidney(2)|large_intestine(1)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	14		all_cancers(22;1.56e-06)|all_epithelial(22;3.17e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.128)		GCGGGAAGCTGAACGTGCACA	0.552000													14	133					0	0	1	0	0
OR2AK2	391191	broad.mit.edu	37	1	248129523	248129523	+	Missense_Mutation	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr1:248129523C>T	ENST00000366480.3	+	1	989	c.890C>T	c.(889-891)aCa>aTa	p.T297I	OR2L13_ENST00000366478.2_Intron	NM_001004491.1	NP_001004491.1	Q8NG84	O2AK2_HUMAN	olfactory receptor, family 2, subfamily AK, member 2	297					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(25)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	36	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			ACCATTGTCACACCTCTACTG	0.473000													25	46					0	0	1	0	0
FAAH2	158584	broad.mit.edu	37	X	57367816	57367816	+	Silent	SNP	T	T	G			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chrX:57367816T>G	ENST00000374900.4	+	5	855	c.735T>G	c.(733-735)ccT>ccG	p.P245P		NM_174912.3	NP_777572.2	Q6GMR7	FAAH2_HUMAN	fatty acid amide hydrolase 2	245						integral to membrane	carbon-nitrogen ligase activity, with glutamine as amido-N-donor|hydrolase activity			endometrium(2)|large_intestine(4)|lung(10)|ovary(3)|upper_aerodigestive_tract(3)	22						GACACAAGCCTTCTCCAGGTA	0.418000										HNSCC(52;0.14)			8	323					0	0	1	0	0
KNTC1	9735	broad.mit.edu	37	12	123070213	123070213	+	Missense_Mutation	SNP	G	G	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr12:123070213G>A	ENST00000333479.7	+	37	3742	c.3565G>A	c.(3565-3567)Gaa>Aaa	p.E1189K	KNTC1_ENST00000450485.2_Intron	NM_014708.4	NP_055523.1	P50748	KNTC1_HUMAN	kinetochore associated 1	1189					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(12)|kidney(8)|large_intestine(12)|lung(20)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	72	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		AGATCCATATGAAGAGTGGTC	0.403000													15	76					0	0	1	0	0
OPRL1	4987	broad.mit.edu	37	20	62729328	62729328	+	Missense_Mutation	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr20:62729328C>T	ENST00000349451.3	+	5	819	c.407C>T	c.(406-408)aCc>aTc	p.T136I	OPRL1_ENST00000355631.4_Missense_Mutation_p.T136I|OPRL1_ENST00000336866.2_Missense_Mutation_p.T136I	NM_001200019.1	NP_001186948.1	P41146	OPRX_HUMAN	opiate receptor-like 1	136					elevation of cytosolic calcium ion concentration|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception	integral to plasma membrane	protein binding|X-opioid receptor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(2)|urinary_tract(1)	19	all_cancers(38;4.74e-11)|all_epithelial(29;1.33e-12)|Lung NSC(23;3.27e-09)|all_lung(23;1.02e-08)					AACATGTTCACCAGCACCTTC	0.582000													5	138					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56473226	56473226	+	Missense_Mutation	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr6:56473226C>T	ENST00000370754.5	-	39	6100	c.6101G>A	c.(6100-6102)cGa>cAa	p.R2034Q	DST_ENST00000244364.6_Intron|DST_ENST00000361203.3_Missense_Mutation_p.R1856Q|DST_ENST00000446842.2_Missense_Mutation_p.R1530Q|DST_ENST00000421834.2_Intron|DST_ENST00000370788.2_Intron|DST_ENST00000370769.4_Missense_Mutation_p.R1856Q|DST_ENST00000312431.6_Missense_Mutation_p.R1856Q			Q03001	DYST_HUMAN	dystonin	1856					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			AACATAGCCTCGCTGAGCTTC	0.438000													31	54					0	0	1	0	0
TMCC2	9911	broad.mit.edu	37	1	205240255	205240255	+	Silent	SNP	C	C	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr1:205240255C>A	ENST00000358024.3	+	4	2079	c.1690C>A	c.(1690-1692)Cgg>Agg	p.R564R	TMCC2_ENST00000329800.7_Silent_p.R324R|TMCC2_ENST00000330675.7_Silent_p.R339R|TMCC2_ENST00000495538.1_3'UTR|TMCC2_ENST00000545499.1_Silent_p.R486R	NM_014858.3	NP_055673.2	O75069	TMCC2_HUMAN	transmembrane and coiled-coil domain family 2	564						integral to membrane	protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|liver(2)|lung(3)|pancreas(1)|skin(1)|urinary_tract(1)	20	Breast(84;0.0871)		BRCA - Breast invasive adenocarcinoma(75;0.117)			CAGGTACGAGCGGCTGGAGGA	0.552000													10	24					7.48243e-07	7.96621e-07	1	1	0
YDJC	150223	broad.mit.edu	37	22	21984245	21984245	+	Missense_Mutation	SNP	C	C	G			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr22:21984245C>G	ENST00000292778.6	-	1	108	c.59G>C	c.(58-60)cGa>cCa	p.R20P	YDJC_ENST00000398873.3_Missense_Mutation_p.R20P	NM_001017964.1	NP_001017964.1	A8MPS7	YDJC_HUMAN	YdjC homolog (bacterial)	20					carbohydrate metabolic process		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds					Colorectal(54;0.105)					CTCATCGCGTCGCGGGCAGTA	0.716000													6	21					0	0	1	0	0
STAT5A	6776	broad.mit.edu	37	17	40453429	40453429	+	Missense_Mutation	SNP	G	G	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr17:40453429G>A	ENST00000345506.4	+	10	1768	c.1126G>A	c.(1126-1128)Gag>Aag	p.E376K	STAT5A_ENST00000546010.2_Missense_Mutation_p.E346K|STAT5A_ENST00000590949.1_Missense_Mutation_p.E376K|STAT5A_ENST00000588868.1_Missense_Mutation_p.E376K|STAT5A_ENST00000452307.2_Missense_Mutation_p.E376K	NM_003152.3	NP_003143.2	P42229	STA5A_HUMAN	signal transducer and activator of transcription 5A	376					2-oxoglutarate metabolic process|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|fatty acid metabolic process|isoleucine metabolic process|oxaloacetate metabolic process|succinate metabolic process|taurine metabolic process|valine metabolic process	cytosol|nucleoplasm	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|kidney(2)|large_intestine(1)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	14		all_cancers(22;1.56e-06)|all_epithelial(22;3.17e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.128)		CATCATCAGTGAGCAGCAGGC	0.587000													16	99					0	0	1	0	0
SMG1	23049	broad.mit.edu	37	16	18866198	18866198	+	Silent	SNP	G	G	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr16:18866198G>T	ENST00000446231.2	-	30	4675	c.4263C>A	c.(4261-4263)ctC>ctA	p.L1421L	SMG1_ENST00000389467.3_Silent_p.L1421L			Q96Q15	SMG1_HUMAN	SMG1 phosphatidylinositol 3-kinase-related kinase	1421	FAT.|Interaction with SMG8 and SMG9.				DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(8)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(37)|ovary(1)|skin(1)|stomach(4)|urinary_tract(1)	92						CTAATTCCATGAGATGGCTTC	0.418000													13	101					0.000151284	0.000157668	1	1	0
CAND1	55832	broad.mit.edu	37	12	67692788	67692788	+	Missense_Mutation	SNP	C	C	G			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr12:67692788C>G	ENST00000545606.1	+	7	1350	c.913C>G	c.(913-915)Ctt>Gtt	p.L305V		NM_018448.3	NP_060918.2	Q86VP6	CAND1_HUMAN	cullin-associated and neddylation-dissociated 1	305					cell differentiation|negative regulation of catalytic activity|protein ubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|ubiquitin ligase complex	protein binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(12)|prostate(1)|skin(2)|stomach(1)	35			GBM - Glioblastoma multiforme(1;1.13e-10)|Lung(24;0.000342)|LUSC - Lung squamous cell carcinoma(43;0.196)	GBM - Glioblastoma multiforme(28;0.0279)		TCTTAAATATCTTACCTATGA	0.318000													4	37					0	0	1	0	0
PCDH20	64881	broad.mit.edu	37	13	61986443	61986443	+	Silent	SNP	G	G	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr13:61986443G>A	ENST00000409186.1	-	5	3894	c.1789C>T	c.(1789-1791)Ctg>Ttg	p.L597L	PCDH20_ENST00000409204.4_Silent_p.L597L			Q8N6Y1	PCD20_HUMAN	protocadherin 20	570	Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(14)|liver(1)|lung(23)|ovary(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	58		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		TCTCGGTCCAGCTGAGTAGAA	0.473000													23	57					0	0	1	0	0
GRIN2B	2904	broad.mit.edu	37	12	13716095	13716095	+	Silent	SNP	G	G	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr12:13716095G>A	ENST00000279593.3	-	13	4286	c.4077C>T	c.(4075-4077)gcC>gcT	p.A1359A		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	1359					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GGTGATGTCCGGCAGTGGGCA	0.587000													31	35					0	0	1	0	0
CREBBP	1387	broad.mit.edu	37	16	3900963	3900963	+	Missense_Mutation	SNP	T	T	C			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr16:3900963T>C	ENST00000262367.5	-	2	942	c.133A>G	c.(133-135)Ata>Gta	p.I45V	CREBBP_ENST00000382070.3_Missense_Mutation_p.I45V	NM_004380.2	NP_004371.2	Q92793	CBP_HUMAN	CREB binding protein	45					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(4)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(125)|kidney(5)|large_intestine(32)|lung(43)|ovary(18)|pancreas(2)|prostate(6)|skin(9)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(21)	295		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		CCATTGGGTATCAGCTCATCA	0.408000			"""T, N, F, Mis, O"""	"""MLL, MORF, RUNXBP2"""	"""ALL, AML, DLBCL, B-NHL """		Rubinstein-Taybi syndrome						17	93					0	0	1	0	0
MYO5A	4644	broad.mit.edu	37	15	52659265	52659265	+	Silent	SNP	G	G	C			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr15:52659265G>C	ENST00000399231.3	-	23	3366	c.3123C>G	c.(3121-3123)ctC>ctG	p.L1041L	MYO5A_ENST00000358212.6_Silent_p.L1041L|MYO5A_ENST00000553916.1_Silent_p.L1041L|MYO5A_ENST00000356338.6_Silent_p.L1041L|MYO5A_ENST00000399233.2_Silent_p.L1041L	NM_000259.3	NP_000250.3	Q9Y4I1	MYO5A_HUMAN	myosin VA (heavy chain 12, myoxin)	1041					actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(7)|large_intestine(12)|lung(19)|ovary(3)|skin(3)|stomach(1)	57				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		TGCGGTGATTGAGGGCTTCTT	0.418000													14	56					0	0	1	0	0
ATG4D	84971	broad.mit.edu	37	19	10657529	10657529	+	Missense_Mutation	SNP	G	G	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr19:10657529G>A	ENST00000309469.4	+	4	681	c.508G>A	c.(508-510)Gag>Aag	p.E170K	ATG4D_ENST00000540862.1_Intron	NM_032885.4	NP_116274.3	Q86TL0	ATG4D_HUMAN	autophagy related 4D, cysteine peptidase	170					autophagy|protein transport	cytoplasm	cysteine-type endopeptidase activity	p.E170K(1)		NS(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	19			Epithelial(33;9.2e-06)|all cancers(31;3.9e-05)			GACATGGGCCGAGGGCATGGG	0.647000													34	41					0	0	1	0	0
CNOT6L	246175	broad.mit.edu	37	4	78650133	78650133	+	Missense_Mutation	SNP	A	A	G			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr4:78650133A>G	ENST00000504123.1	-	10	1257	c.1127T>C	c.(1126-1128)aTg>aCg	p.M376T	CNOT6L_ENST00000264903.4_Missense_Mutation_p.M376T			Q96LI5	CNO6L_HUMAN	CCR4-NOT transcription complex, subunit 6-like	376					nuclear-transcribed mRNA poly(A) tail shortening	cytosol	exonuclease activity|protein binding			kidney(1)|large_intestine(1)|lung(6)|urinary_tract(1)	9						GACAAACATCATGGTCTGGAT	0.473000													19	114					0	0	1	0	0
ELL2	22936	broad.mit.edu	37	5	95234177	95234177	+	Missense_Mutation	SNP	G	G	C			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr5:95234177G>C	ENST00000237853.4	-	8	1641	c.1292C>G	c.(1291-1293)tCt>tGt	p.S431C	ELL2_ENST00000431061.2_Missense_Mutation_p.S181C	NM_012081.5	NP_036213.2	O00472	ELL2_HUMAN	elongation factor, RNA polymerase II, 2	431					regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter	transcription elongation factor complex				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(10)|pancreas(1)|prostate(2)	24		all_cancers(142;2.04e-06)|all_epithelial(76;3.1e-09)|all_lung(232;0.00309)|Lung NSC(167;0.00454)|Ovarian(225;0.0165)|Colorectal(57;0.0343)|Breast(839;0.198)		all cancers(79;2.16e-15)		AGAAGTCCTAGAGGTATATTT	0.448000													84	85					0	0	1	0	0
FGF17	8822	broad.mit.edu	37	8	21905600	21905600	+	Missense_Mutation	SNP	G	G	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr8:21905600G>A	ENST00000359441.3	+	5	994	c.491G>A	c.(490-492)cGc>cAc	p.R164H	FGF17_ENST00000518533.1_Missense_Mutation_p.R153H|FGF17_ENST00000521709.1_3'UTR	NM_003867.2	NP_003858.1	O60258	FGF17_HUMAN	fibroblast growth factor 17	164					cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|nervous system development	extracellular space	growth factor activity|type 1 fibroblast growth factor receptor binding|type 2 fibroblast growth factor receptor binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|skin(1)	8				Colorectal(74;8.48e-05)|READ - Rectum adenocarcinoma(5;0.0276)|COAD - Colon adenocarcinoma(73;0.0618)		CAGGCTTCCCGCAGCCGCCAG	0.647000													14	10					0	0	1	0	0
USP36	57602	broad.mit.edu	37	17	76798577	76798577	+	Missense_Mutation	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr17:76798577C>T	ENST00000312010.6	-	17	3175	c.2851G>A	c.(2851-2853)Gag>Aag	p.E951K	USP36_ENST00000542802.2_Missense_Mutation_p.E951K|USP36_ENST00000449938.2_Missense_Mutation_p.E556K	NM_025090.3	NP_079366.3	Q9P275	UBP36_HUMAN	ubiquitin specific peptidase 36	951					ubiquitin-dependent protein catabolic process	nucleolus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	34			BRCA - Breast invasive adenocarcinoma(99;0.000842)|OV - Ovarian serous cystadenocarcinoma(97;0.151)			CTTGGAGACTCTTCCATGGCC	0.532000													10	39					0	0	1	0	0
MAGEC2	51438	broad.mit.edu	37	X	141291308	141291308	+	Missense_Mutation	SNP	A	A	G			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chrX:141291308A>G	ENST00000247452.3	-	3	813	c.466T>C	c.(466-468)Tac>Cac	p.Y156H		NM_016249.3	NP_057333.1	Q9UBF1	MAGC2_HUMAN	melanoma antigen family C, 2	156	MAGE.					cytoplasm|nucleus				NS(2)|breast(3)|endometrium(3)|kidney(2)|large_intestine(8)|lung(18)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(3)	47	Acute lymphoblastic leukemia(192;6.56e-05)					TCTGCTTCGTATTTGAGGAGC	0.478000										HNSCC(46;0.14)			50	262					0	0	1	0	0
SLC12A8	84561	broad.mit.edu	37	3	124906188	124906188	+	Missense_Mutation	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr3:124906188C>T	ENST00000423114.2	-	4	369	c.370G>A	c.(370-372)Gtc>Atc	p.V124I	SLC12A8_ENST00000314584.7_5'UTR|SLC12A8_ENST00000469902.1_Missense_Mutation_p.V95I|SLC12A8_ENST00000393469.4_Missense_Mutation_p.V95I			A0AV02	S12A8_HUMAN	solute carrier family 12, member 8	95					potassium ion transport	integral to membrane	symporter activity			endometrium(2)|kidney(2)|lung(12)	16						CGCTCCCCGACGCCAATGCCA	0.622000													21	34					0	0	1	0	0
ITIH6	347365	broad.mit.edu	37	X	54814982	54814982	+	Silent	SNP	C	C	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chrX:54814982C>A	ENST00000218436.6	-	5	746	c.717G>T	c.(715-717)ggG>ggT	p.G239G	ITIH6_ENST00000498398.1_5'UTR	NM_198510.2	NP_940912.1	Q6UXX5	ITH5L_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 6	239					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity										TGATGCCTGACCCAGAGATGG	0.572000													15	45					0.000219431	0.000227729	1	1	0
CNTN6	27255	broad.mit.edu	37	3	1363491	1363491	+	Missense_Mutation	SNP	C	C	G			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr3:1363491C>G	ENST00000446702.2	+	8	1546	c.919C>G	c.(919-921)Ctt>Gtt	p.L307V	CNTN6_ENST00000539053.1_Missense_Mutation_p.L235V|CNTN6_ENST00000350110.2_Missense_Mutation_p.L307V			Q9UQ52	CNTN6_HUMAN	contactin 6	307	Ig-like C2-type 3.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				breast(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(34)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		AGGAAGAAACCTTGCAAAGGG	0.358000													18	106					0	0	1	0	0
TNIP1	10318	broad.mit.edu	37	5	150422172	150422172	+	Missense_Mutation	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr5:150422172C>T	ENST00000389378.2	-	11	1651	c.1063G>A	c.(1063-1065)Gag>Aag	p.E355K	TNIP1_ENST00000524280.1_Missense_Mutation_p.E355K|TNIP1_ENST00000518977.1_Missense_Mutation_p.E355K|TNIP1_ENST00000523200.1_Missense_Mutation_p.E355K|TNIP1_ENST00000521423.1_Intron|TNIP1_ENST00000523338.1_Missense_Mutation_p.E355K|TNIP1_ENST00000315050.7_Missense_Mutation_p.E355K|TNIP1_ENST00000522226.1_Missense_Mutation_p.E355K|TNIP1_ENST00000521591.1_Missense_Mutation_p.E355K|TNIP1_ENST00000520931.1_Missense_Mutation_p.E302K	NM_001252385.1|NM_001252393.1|NM_001258454.1|NM_006058.4	NP_001239314.1|NP_001239322.1|NP_001245383.1|NP_006049.3	Q15025	TNIP1_HUMAN	TNFAIP3 interacting protein 1	355	Interacts with Nef.				defense response|glycoprotein biosynthetic process|negative regulation of viral genome replication|translation	cytoplasm|nucleus	protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|liver(1)|lung(5)|ovary(2)|prostate(2)|skin(3)	23		Medulloblastoma(196;0.0911)|all_hematologic(541;0.207)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TGCTCCCGCTCGGCCTCCAGG	0.572000													8	45					0	0	1	0	0
CXorf56	63932	broad.mit.edu	37	X	118678342	118678342	+	Missense_Mutation	SNP	T	T	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chrX:118678342T>A	ENST00000320339.4	-	4	521	c.250A>T	c.(250-252)Act>Tct	p.T84S	CXorf56_ENST00000371594.4_Missense_Mutation_p.T133S|CXorf56_ENST00000536133.1_Missense_Mutation_p.T119S|CXorf56_ENST00000486230.1_Missense_Mutation_p.T133S|CXorf56_ENST00000476164.1_Missense_Mutation_p.T133S	NM_001170569.1	NP_001164040.1	Q9H5V9	CX056_HUMAN	chromosome X open reading frame 56	133							protein binding			cervix(1)|endometrium(2)|lung(7)	10						TGTTTCTGAGTATATATGTTC	0.403000													43	245					0	0	1	0	0
GGT3P	2679	broad.mit.edu	37	22	18769145	18769145	+	RNA	SNP	G	G	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr22:18769145G>A	ENST00000412448.1	-	0	1141																											TGAGGCTGCCGTTGTAGAAGG	0.612000													5	37					0	0	1	0	0
ZNF585B	92285	broad.mit.edu	37	19	37677976	37677976	+	Missense_Mutation	SNP	C	C	G			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr19:37677976C>G	ENST00000532828.2	-	5	714	c.463G>C	c.(463-465)Gaa>Caa	p.E155Q	ZNF585B_ENST00000531805.1_Missense_Mutation_p.E100Q|ZNF585B_ENST00000312908.5_Intron|ZNF585B_ENST00000527838.1_Intron|CTC-454I21.3_ENST00000585860.2_Intron	NM_152279.3	NP_689492.3	Q52M93	Z585B_HUMAN	zinc finger protein 585B	155					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|endometrium(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)	29			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TAGAGTTTTTCTCCTGTAGGA	0.393000													18	512					0	0	1	0	0
DENND1A	57706	broad.mit.edu	37	9	126214554	126214554	+	Splice_Site	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr9:126214554C>T	ENST00000373624.2	-	17	1501		c.e17+1		DENND1A_ENST00000542603.1_Splice_Site|DENND1A_ENST00000373618.1_Splice_Site|DENND1A_ENST00000394215.2_Splice_Site|DENND1A_ENST00000373620.3_Splice_Site|DENND1A_ENST00000394219.3_Splice_Site|DENND1A_ENST00000473039.1_Splice_Site	NM_020946.1	NP_065997.1	Q8TEH3	DEN1A_HUMAN	DENN/MADD domain containing 1A							cell junction|clathrin coated vesicle membrane|presynaptic membrane	guanyl-nucleotide exchange factor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|liver(2)|lung(18)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43						CCAGTACTTACGAACTTGTAG	0.378000													10	99					0	0	1	0	0
TRAF3IP1	26146	broad.mit.edu	37	2	239258006	239258006	+	Missense_Mutation	SNP	C	C	G			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr2:239258006C>G	ENST00000373327.4	+	12	1630	c.1408C>G	c.(1408-1410)Cgg>Ggg	p.R470G	TRAF3IP1_ENST00000391994.2_Missense_Mutation_p.R470G|TRAF3IP1_ENST00000391993.3_Missense_Mutation_p.R404G	NM_015650.3	NP_056465.2	Q8TDR0	MIPT3_HUMAN	TNF receptor-associated factor 3 interacting protein 1	470	DISC1-interaction domain.					cytoplasm|cytoskeleton	protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(9)|ovary(2)|prostate(1)|skin(2)	23		all_epithelial(40;3.22e-10)|Breast(86;0.000523)|Renal(207;0.00571)|Ovarian(221;0.156)|all_hematologic(139;0.182)		Epithelial(121;9.92e-24)|OV - Ovarian serous cystadenocarcinoma(60;7.85e-12)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.01e-07)|BRCA - Breast invasive adenocarcinoma(100;7.72e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.0184)		AGCCCCTCCCCGGGTCAAACG	0.507000													11	31					0	0	1	0	0
FBXO39	162517	broad.mit.edu	37	17	6684174	6684174	+	Silent	SNP	G	G	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr17:6684174G>A	ENST00000321535.4	+	2	1117	c.987G>A	c.(985-987)ctG>ctA	p.L329L		NM_153230.2	NP_694962.1	Q8N4B4	FBX39_HUMAN	F-box protein 39	329										NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(5)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	26						GACCCACTCTGATAGATCTCC	0.542000													12	55					0	0	1	0	0
CTC-260E6.6	0	broad.mit.edu	37	19	20369957	20369957	+	RNA	SNP	A	A	G			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr19:20369957A>G	ENST00000593655.1	-	0	199																											TGCTTTCTGGAGGGTCTACTA	0.403000													5	54					0	0	1	0	0
RSPRY1	89970	broad.mit.edu	37	16	57238645	57238645	+	Missense_Mutation	SNP	G	G	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr16:57238645G>T	ENST00000537866.1	+	2	948	c.75G>T	c.(73-75)gaG>gaT	p.E25D	RSPRY1_ENST00000394420.4_Missense_Mutation_p.E25D			Q96DX4	RSPRY_HUMAN	ring finger and SPRY domain containing 1	25						extracellular region	zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|urinary_tract(3)	27						CTCTCGAAGAGCACATAGCCC	0.502000													11	166					0.000308642	0.000316326	1	1	0
CDKN2A	1029	broad.mit.edu	37	9	21971120	21971120	+	Nonsense_Mutation	SNP	G	G	A	rs121913388		TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr9:21971120G>A	ENST00000304494.5	-	2	508	c.238C>T	c.(238-240)Cga>Tga	p.R80*	RP11-145E5.5_ENST00000404796.2_Intron|CDKN2A_ENST00000579755.1_Missense_Mutation_p.P94L|CDKN2A_ENST00000497750.1_Nonsense_Mutation_p.R29*|CDKN2A_ENST00000494262.1_Nonsense_Mutation_p.R29*|CDKN2A_ENST00000479692.2_Nonsense_Mutation_p.R29*|CDKN2A_ENST00000579122.1_Nonsense_Mutation_p.R80*|CDKN2A_ENST00000446177.1_Nonsense_Mutation_p.R80*|CDKN2A_ENST00000498124.1_Nonsense_Mutation_p.R80*|CDKN2A_ENST00000578845.2_Nonsense_Mutation_p.R29*|CDKN2A_ENST00000530628.2_Missense_Mutation_p.P94L|CDKN2A_ENST00000498628.2_Nonsense_Mutation_p.R29*|CDKN2A_ENST00000361570.3_Missense_Mutation_p.P135L	NM_000077.4	NP_000068.1	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A	80			R -> L (in a head and neck tumor).|R -> P (in CMM2; loss of CDK4 binding).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein kinase binding	p.0?(1315)|p.R80*(100)|p.?(44)|p.P135L(7)|p.L65fs*38(1)|p.T79fs*37(1)|p.0(1)|p.A76fs*64(1)|p.T79fs*65(1)|p.E61_L94del(1)|p.A68fs*3(1)|p.R80fs*34(1)		NS(28)|adrenal_gland(6)|autonomic_ganglia(11)|biliary_tract(74)|bone(84)|breast(46)|central_nervous_system(522)|cervix(23)|endometrium(14)|eye(4)|genital_tract(15)|haematopoietic_and_lymphoid_tissue(698)|kidney(39)|large_intestine(11)|liver(92)|lung(365)|meninges(18)|oesophagus(239)|ovary(98)|pancreas(263)|pleura(94)|prostate(13)|salivary_gland(10)|skin(541)|small_intestine(1)|soft_tissue(93)|stomach(48)|thymus(4)|thyroid(24)|upper_aerodigestive_tract(436)|urinary_tract(283)|vulva(2)	4199		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TGCACGGGTCGGGTGAGAGTG	0.726000	R80*(HSC4_UPPER_AERODIGESTIVE_TRACT)|R80*(MEWO_SKIN)	17								HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			16	8					0	0	1	0	0
ANXA10	11199	broad.mit.edu	37	4	169060724	169060724	+	Missense_Mutation	SNP	A	A	G			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr4:169060724A>G	ENST00000359299.3	+	3	374	c.188A>G	c.(187-189)tAt>tGt	p.Y63C		NM_007193.4	NP_009124.2	Q9UJ72	ANX10_HUMAN	annexin A10	63							calcium ion binding|calcium-dependent phospholipid binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(6)|prostate(1)|stomach(2)	16		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0325)		CAGAGCATGTATGGCCGGGTA	0.418000													9	22					0	0	1	0	0
FRA10AC1	118924	broad.mit.edu	37	10	95458092	95458092	+	Missense_Mutation	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr10:95458092C>T	ENST00000359204.4	-	3	336	c.139G>A	c.(139-141)Gcc>Acc	p.A47T	FRA10AC1_ENST00000536233.1_Missense_Mutation_p.A47T|FRA10AC1_ENST00000394100.2_Missense_Mutation_p.A47T|FRA10AC1_ENST00000371430.2_Missense_Mutation_p.A47T	NM_145246.4	NP_660289.2	Q70Z53	F10C1_HUMAN	fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1	47						nucleus	protein binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(4)|urinary_tract(1)	14						TGTTTATGGGCCACCTTTCCA	0.348000													22	63					0	0	1	0	0
RAB35	11021	broad.mit.edu	37	12	120541715	120541715	+	Missense_Mutation	SNP	G	G	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr12:120541715G>A	ENST00000229340.5	-	3	330	c.142C>T	c.(142-144)Cgg>Tgg	p.R48W	RAB35_ENST00000534951.1_Missense_Mutation_p.R48W	NM_001167606.1|NM_006861.6	NP_001161078.1|NP_006852.1	Q15286	RAB35_HUMAN	RAB35, member RAS oncogene family	48					cytokinesis|endosome transport|protein transport|small GTPase mediated signal transduction	cell projection membrane|clathrin-coated endocytic vesicle|coated pit|endosome|intercellular bridge|melanosome	GTP binding|GTPase activity|phosphatidylinositol-4,5-bisphosphate binding			endometrium(1)|ovary(1)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.248)		TCCACGGTCCGGATCTTGAAA	0.622000													33	38					0	0	1	0	0
TRIM6-TRIM34	445372	broad.mit.edu	37	11	5655105	5655105	+	Silent	SNP	C	C	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr11:5655105C>A	ENST00000354852.5	+	9	1730	c.1557C>A	c.(1555-1557)atC>atA	p.I519I	TRIM6-TRIM34_ENST00000457787.2_Silent_p.I165I|TRIM34_ENST00000429814.2_Silent_p.I165I|TRIM34_ENST00000514226.1_Silent_p.I165I|HBG2_ENST00000380259.2_Intron	NM_001003819.3	NP_001003819.1	B2RNG4	B2RNG4_HUMAN		519						intracellular	zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(12)|lung(9)|ovary(1)|prostate(2)|stomach(2)|urinary_tract(1)	33		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;1.01e-08)|BRCA - Breast invasive adenocarcinoma(625;0.145)		AAGCTGACATCAGAGAAGAGA	0.473000													6	40					0.0215528	0.0216404	1	1	0
TLR8	51311	broad.mit.edu	37	X	12939373	12939373	+	Silent	SNP	G	G	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chrX:12939373G>A	ENST00000218032.6	+	2	2301	c.2214G>A	c.(2212-2214)ctG>ctA	p.L738L	TLR8_ENST00000311912.5_Silent_p.L756L	NM_138636.4	NP_619542.1	Q9NR97	TLR8_HUMAN	toll-like receptor 8	738					cellular response to mechanical stimulus|defense response to virus|I-kappaB kinase/NF-kappaB cascade|immunoglobulin mediated immune response|inflammatory response|innate immune response|positive regulation of innate immune response|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process	endosome membrane	DNA binding|double-stranded RNA binding|single-stranded RNA binding|transmembrane receptor activity			breast(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(21)|ovary(4)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	50						TCAGTAGTCTGAAGCACCTCG	0.423000													24	187					0	0	1	0	0
TIGD3	220359	broad.mit.edu	37	11	65124617	65124617	+	Silent	SNP	A	A	G			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr11:65124617A>G	ENST00000309880.5	+	2	1545	c.1338A>G	c.(1336-1338)gaA>gaG	p.E446E		NM_145719.2	NP_663771.1	Q6B0B8	TIGD3_HUMAN	tigger transposable element derived 3	446					regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding			endometrium(3)|large_intestine(1)|lung(9)|prostate(2)|skin(2)	17						GGTGGTTTGAATGCAACAGCA	0.577000													28	49					0	0	1	0	0
COX15	1355	broad.mit.edu	37	10	101474348	101474348	+	Missense_Mutation	SNP	T	T	G			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr10:101474348T>G	ENST00000016171.5	-	9	1279	c.1229A>C	c.(1228-1230)aAa>aCa	p.K410T	CUTC_ENST00000493385.1_Intron|COX15_ENST00000370483.5_Intron			Q7KZN9	COX15_HUMAN	cytochrome c oxidase assembly homolog 15 (yeast)	410					heme a biosynthetic process|respiratory chain complex IV assembly|respiratory gaseous exchange	integral to membrane|mitochondrial respiratory chain	cytochrome-c oxidase activity			endometrium(1)|kidney(1)|large_intestine(4)|liver(1)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	13		Colorectal(252;0.234)		Epithelial(162;3.08e-10)|all cancers(201;2.43e-08)		TAAGAATCATTTTGGGACTCT	0.493000													8	44					0	0	1	0	0
LRIT1	26103	broad.mit.edu	37	10	85997337	85997337	+	Silent	SNP	G	G	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr10:85997337G>T	ENST00000372105.3	-	2	249	c.228C>A	c.(226-228)ggC>ggA	p.G76G		NM_015613.2	NP_056428.1	Q9P2V4	LRIT1_HUMAN	leucine-rich repeat, immunoglobulin-like and transmembrane domains 1	76						integral to endoplasmic reticulum membrane				breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|skin(1)	23						TGAAGGCCTCGCCAGGAACCC	0.701000													12	45					0.000978159	0.000998369	1	1	0
TRAK2	66008	broad.mit.edu	37	2	202245628	202245628	+	Missense_Mutation	SNP	G	G	C			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr2:202245628G>C	ENST00000332624.3	-	16	2811	c.2383C>G	c.(2383-2385)Cga>Gga	p.R795G		NM_015049.2	NP_055864.2	O60296	TRAK2_HUMAN	trafficking protein, kinesin binding 2	795				Missing (in Ref. 2).		early endosome|plasma membrane	GABA receptor binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(12)|ovary(1)|skin(1)	23						AGATGCACTCGAGGCTCAAAG	0.532000													18	90					0	0	1	0	0
CTSF	8722	broad.mit.edu	37	11	66335131	66335131	+	Silent	SNP	G	G	C			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr11:66335131G>C	ENST00000310325.5	-	3	424	c.315C>G	c.(313-315)ctC>ctG	p.L105L	CTSF_ENST00000533168.1_5'UTR	NM_003793.3	NP_003784.2	Q9UBX1	CATF_HUMAN	cathepsin F	105					proteolysis	lysosome	cysteine-type endopeptidase activity			endometrium(1)|large_intestine(7)|lung(8)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	19						GGAAGCTGCAGAGCTGGAGGG	0.607000													7	45					0	0	1	0	0
KLHL38	340359	broad.mit.edu	37	8	124664012	124664012	+	Missense_Mutation	SNP	G	G	C			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr8:124664012G>C	ENST00000325995.7	-	1	1178	c.1155C>G	c.(1153-1155)atC>atG	p.I385M	CTD-2552K11.2_ENST00000524355.1_RNA	NM_001081675.2	NP_001075144.2	Q2WGJ6	KLH38_HUMAN	kelch-like family member 38	385										breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(16)|pancreas(1)|prostate(3)|stomach(1)	38						CGATGGAGAAGATGAAGTTCT	0.557000													6	157					0	0	1	0	0
GALNT10	55568	broad.mit.edu	37	5	153796440	153796440	+	Missense_Mutation	SNP	T	T	G			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr5:153796440T>G	ENST00000297107.6	+	12	1857	c.1720T>G	c.(1720-1722)Ttc>Gtc	p.F574V	GALNT10_ENST00000377661.2_Missense_Mutation_p.F512V|GALNT10_ENST00000377657.3_Missense_Mutation_p.F247V|SAP30L-AS1_ENST00000519727.1_RNA|SAP30L-AS1_ENST00000524264.1_RNA	NM_198321.3	NP_938080.1	Q86SR1	GLT10_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)	574	Ricin B-type lectin.					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(12)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	32	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)|all_hematologic(541;0.21)	Kidney(363;8.21e-05)|KIRC - Kidney renal clear cell carcinoma(527;0.000577)			CCATAGGATCTTCATGAACAC	0.488000													7	91					0	0	1	0	0
SLC4A2	6522	broad.mit.edu	37	7	150771302	150771302	+	Silent	SNP	G	G	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr7:150771302G>A	ENST00000485713.1	+	17	3752	c.2712G>A	c.(2710-2712)tcG>tcA	p.S904S	SLC4A2_ENST00000413384.2_Silent_p.S904S|SLC4A2_ENST00000392826.2_Silent_p.S895S|SLC4A2_ENST00000310317.5_Silent_p.S822S|SLC4A2_ENST00000461735.1_Silent_p.S890S	NM_001199692.1	NP_001186621.1	P04920	B3A2_HUMAN	solute carrier family 4 (anion exchanger), member 2	904	Membrane (anion exchange).				bicarbonate transport	integral to membrane|membrane fraction	inorganic anion exchanger activity			NS(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(2)|liver(2)|lung(14)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	33			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CCCTGCTGTCGCTGGTGCTCA	0.667000													9	73					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49445325	49445325	+	Missense_Mutation	SNP	G	G	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr12:49445325G>A	ENST00000301067.7	-	10	2140	c.2141C>T	c.(2140-2142)tCg>tTg	p.S714L		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		GGACATGAGCGAGTCCTCCGG	0.682000													29	152					0	0	1	0	0
IL17RC	84818	broad.mit.edu	37	3	9974768	9974768	+	Missense_Mutation	SNP	C	C	T			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr3:9974768C>T	ENST00000295981.3	+	19	2085	c.1867C>T	c.(1867-1869)Cgt>Tgt	p.R623C	IL17RC_ENST00000413608.1_Missense_Mutation_p.R539C|IL17RC_ENST00000455057.1_Missense_Mutation_p.R520C|IL17RC_ENST00000416074.2_Missense_Mutation_p.R378C|IL17RC_ENST00000383812.4_Missense_Mutation_p.R537C|IL17RC_ENST00000498214.1_3'UTR|IL17RC_ENST00000403601.3_Missense_Mutation_p.R552C	NM_153461.3	NP_703191.1	Q8NAC3	I17RC_HUMAN	interleukin 17 receptor C	623	SEFIR.					integral to membrane|plasma membrane	receptor activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(3)|ovary(3)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	22						GTGGAGCCGTCGTGAACTGAG	0.706000											OREG0015383	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	17					0	0	1	0	0
KIAA0907	22889	broad.mit.edu	37	1	155886422	155886423	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr1:155886422_155886423delCT	ENST00000368320.3	-	12	1571_1572	c.1546_1547delAG	c.(1546-1548)gfs	p.R516fs	KIAA0907_ENST00000368321.3_Frame_Shift_Del_p.R516fs			Q7Z7F0	K0907_HUMAN	KIAA0907	516								p.R516fs*21(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|urinary_tract(1)	21	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;8.82e-06)			TTACCTGTCCCTCTCTCTCTCT	0.396													8	150	---	---	---	---					
CASP8	841	broad.mit.edu	37	2	202136345	202136348	+	Splice_Site	DEL	GTAA	GTAA	-			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr2:202136345_202136348delGTAA	ENST00000358485.4	+	3	784		c.e3+1		CASP8_ENST00000392266.3_Splice_Site|CASP8_ENST00000392258.3_Splice_Site|CASP8_ENST00000392259.2_Splice_Site|CASP8_ENST00000264274.9_Splice_Site|CASP8_ENST00000264275.5_Splice_Site|CASP8_ENST00000323492.7_Splice_Site|CASP8_ENST00000432109.2_Splice_Site	NM_001080125.1	NP_001073594.1	Q14790	CASP8_HUMAN	caspase 8, apoptosis-related cysteine peptidase						activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding			breast(5)|cervix(2)|endometrium(6)|large_intestine(11)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(9)|urinary_tract(3)	52						TGATGACATGGTAAGACCTGGTAT	0.417										HNSCC(4;0.00038)			14	45	---	---	---	---					
UGT2A2	574537	broad.mit.edu	37	4	70504697	70504697	+	Frame_Shift_Del	DEL	T	T	-			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr4:70504697delT	ENST00000457664.2	-	1	661	c.662delA	c.(661-663)atfs	p.N221fs	UGT2A1_ENST00000512704.1_Intron|UGT2A1_ENST00000503640.1_Intron|UGT2A1_ENST00000514019.1_Frame_Shift_Del_p.N422fs|UGT2A1_ENST00000286604.4_Intron	NM_001105677.2	NP_001099147.2																					AGATATGGTATTTTTAATCCT	0.398													8	38	---	---	---	---					
LINC01331	104310351	broad.mit.edu	37	5	73726286	73726286	+	RNA	DEL	A	A	-	rs148954741		TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr5:73726286delA	ENST00000507781.1	-	0	422																											acagccacccaacgtgatgag	0.567													6	1	---	---	---	---					
FAT2	2196	broad.mit.edu	37	5	150889584	150889602	+	Frame_Shift_Del	DEL	GTCTCCTGTGTAAGGATGA	GTCTCCTGTGTAAGGATGA	-			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr5:150889584_150889602delGTCTCCTGTGTAAGGATGA	ENST00000261800.5	-	21	12051_12069	c.12039_12057delTCATCCTTACACAGGAGAC	c.(12037-12057)ccfs	p.PHPYTGD4013fs	CTC-251D13.1_ENST00000606930.1_RNA	NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	4013	EGF-like 2.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGGATTACCTGTCTCCTGTGTAAGGATGAGGGCAGTTAC	0.548													48	128	---	---	---	---					
HLA-A	3105	broad.mit.edu	37	6	29910692	29910693	+	Frame_Shift_Ins	INS	-	-	A	rs41559716	by1000genomes	TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr6:29910692_29910693insA	ENST00000396634.1	+	4	573_574	c.232_233insA	c.(232-234)ggafs	p.G78fs	HLA-A_ENST00000376806.5_Frame_Shift_Ins_p.G78fs|HLA-A_ENST00000376809.5_Frame_Shift_Ins_p.G78fs|HLA-A_ENST00000376802.2_Frame_Shift_Ins_p.G78fs			P30443	1A01_HUMAN	major histocompatibility complex, class I, A	78	Alpha-1.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity	p.Q78R(2)|p.Q78*(1)		central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	30						GTGGATAGAGCAGGAGGGGCCG	0.658									Osteosarcoma, Familial Clustering of;Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of;Melanoma, Familial Clustering of;Lichen Sclerosis et Atrophicus, Familial Clustering of	Multiple Myeloma(9;0.094)			9	48	---	---	---	---					
ZNF292	23036	broad.mit.edu	37	6	87968210	87968211	+	Frame_Shift_Ins	INS	-	-	A			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr6:87968210_87968211insA	ENST00000369577.3	+	8	4906_4907	c.4863_4864insA	c.(4861-4866)aaaaaafs	p.KK1621fs	ZNF292_ENST00000339907.4_Frame_Shift_Ins_p.KK1616fs	NM_015021.1	NP_055836.1	O60281	ZN292_HUMAN	zinc finger protein 292	1621					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(27)|lung(21)|ovary(4)|prostate(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	89		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		GTCATTTAAATAAAAAGGGAAA	0.381													7	35	---	---	---	---					
TRIM4	89122	broad.mit.edu	37	7	99489911	99489913	+	In_Frame_Del	DEL	AGA	AGA	-			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr7:99489911_99489913delAGA	ENST00000355947.2	-	7	1505_1507	c.1376_1378delTCT	c.(1375-1380)tac>t	p.FY459del	TRIM4_ENST00000349062.2_In_Frame_Del_p.FY433del	NM_033017.3	NP_148977.2	Q9C037	TRIM4_HUMAN	tripartite motif containing 4	459	B30.2/SPRY.				protein trimerization	cytoplasm|plasma membrane	zinc ion binding	p.F459S(1)		breast(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|skin(1)	17	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)	Ovarian(593;0.238)				ACAGCGCTGTAGAAGGAGACATT	0.532													45	165	---	---	---	---					
ZFHX4	79776	broad.mit.edu	37	8	77754951	77754951	+	Frame_Shift_Del	DEL	A	A	-			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr8:77754951delA	ENST00000521891.2	+	6	3903	c.3455delA	c.(3454-3456)gafs	p.E1152fs	ZFHX4_ENST00000455469.2_Frame_Shift_Del_p.E1117fs|ZFHX4_ENST00000518282.1_Frame_Shift_Del_p.E1126fs|ZFHX4_ENST00000050961.6_Frame_Shift_Del_p.E1117fs	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	1117						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GAGGACGATGAAAAAGACACA	0.433										HNSCC(33;0.089)			2	4	---	---	---	---					
GPR19	2842	broad.mit.edu	37	12	12814274	12814274	+	Frame_Shift_Del	DEL	T	T	-			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr12:12814274delT	ENST00000540510.1	-	2	1301	c.1109delA	c.(1108-1110)acfs	p.N370fs	GPR19_ENST00000332427.2_Frame_Shift_Del_p.N370fs			Q15760	GPR19_HUMAN	G protein-coupled receptor 19	370						integral to plasma membrane	G-protein coupled receptor activity			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	17		Prostate(47;0.0802)		BRCA - Breast invasive adenocarcinoma(232;0.048)		GCCAACGTAGTTTTTTTTGGC	0.398													7	229	---	---	---	---					
KDELC1	79070	broad.mit.edu	37	13	103443722	103443722	+	Frame_Shift_Del	DEL	T	T	-			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr13:103443722delT	ENST00000376004.4	-	5	1067	c.731delA	c.(730-732)agfs	p.K245fs	KDELC1_ENST00000460338.1_5'UTR	NM_024089.2	NP_076994.2	Q6UW63	KDEL1_HUMAN	KDEL (Lys-Asp-Glu-Leu) containing 1	245						endoplasmic reticulum lumen				central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|skin(1)	19	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					ATTGGATTTCTTTTTTTCCAA	0.418													8	983	---	---	---	---					
GOLGA6B	55889	broad.mit.edu	37	15	72957311	72957313	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr15:72957311_72957313delGAG	ENST00000421285.3	+	14	1528_1530	c.1528_1530delGAG	c.(1528-1530)del	p.E513del		NM_018652.4	NP_061122.4	A6NDN3	GOG6B_HUMAN	golgin A6 family, member B	513										NS(1)|breast(1)|endometrium(1)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	16						TCTGGACAGTGAGGAGGAGGAGG	0.635													2	4	---	---	---	---					
KCTD1	284252	broad.mit.edu	37	18	24128325	24128327	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr18:24128325_24128327delTCC	ENST00000417602.1	-	1	173_175	c.174_176delGGA	c.(172-177)gaa>ga	p.EE62del	KCTD1_ENST00000317932.7_Intron|KCTD1_ENST00000408011.3_Intron|KCTD1_ENST00000579973.1_Intron	NM_001142730.2	NP_001136202.1	Q719H9	KCTD1_HUMAN	potassium channel tetramerization domain containing 1	0	BTB.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|voltage-gated potassium channel complex	transcription corepressor activity|transcription factor binding|voltage-gated potassium channel activity			endometrium(2)|large_intestine(3)|lung(3)|ovary(1)|prostate(3)	12	all_cancers(21;0.00191)|Lung NSC(5;0.000698)|all_lung(6;0.0019)|Ovarian(20;0.0848)		Epithelial(2;7.8e-06)|OV - Ovarian serous cystadenocarcinoma(3;9.02e-06)|all cancers(3;3.37e-05)			ctcctcctcttcctcctcctcct	0.724													2	4	---	---	---	---					
WDR62	284403	broad.mit.edu	37	19	36583666	36583668	+	In_Frame_Del	DEL	GCA	GCA	-			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chr19:36583666_36583668delGCA	ENST00000401500.2	+	19	2321_2323	c.2286_2288delGCA	c.(2284-2289)cgg>cg	p.RQ762del	WDR62_ENST00000270301.7_In_Frame_Del_p.RQ762del	NM_001083961.1|NM_173636.4	NP_001077430.1|NP_775907.4	O43379	WDR62_HUMAN	WD repeat domain 62	762					cerebral cortex development	nucleus				cervix(1)|endometrium(8)|kidney(2)|large_intestine(8)|lung(15)|prostate(4)|stomach(2)|urinary_tract(3)	43	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			TTGACCACCGGCAGCAGCAGCAG	0.616													7	663	---	---	---	---					
CNKSR2	22866	broad.mit.edu	37	X	21670433	21670433	+	Frame_Shift_Del	DEL	G	G	-			TCGA-RS-A6TO-01A-32D-A34J-08	TCGA-RS-A6TO-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c62fe6c-36a1-427c-bc96-9beb9f8468bb	56e2c4b0-114d-40f4-aa85-753b0df44efd	g.chrX:21670433delG	ENST00000425654.2	+	21	3289	c.2809delG	c.(2809-2811)ggfs	p.G937fs	CNKSR2_ENST00000379510.3_Frame_Shift_Del_p.G967fs	NM_001168647.1	NP_001162118.1	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras 2	967					regulation of signal transduction	cytoplasm|membrane	protein binding			breast(3)|endometrium(8)|kidney(2)|large_intestine(15)|lung(28)|prostate(2)|upper_aerodigestive_tract(3)	61						GGCCAGAGAAGGGGAAGTAGC	0.348													37	106	---	---	---	---