Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
FAM169B	283777	broad.mit.edu	37	15	99023882	99023882	+	Missense_Mutation	SNP	T	T	A			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr15:99023882T>A	ENST00000558256.1	-	4	380	c.131A>T	c.(130-132)aAa>aTa	p.K44I	FAM169B_ENST00000332908.4_Missense_Mutation_p.K44I	NM_182562.2	NP_872368.2	Q8N8A8	F169B_HUMAN	family with sequence similarity 169, member B	44										large_intestine(3)|lung(3)|urinary_tract(1)	7						CCACAGGATTTTAGCTTGTTC	0.453000													18	76					0	0	1	0	0
ZFP28	140612	broad.mit.edu	37	19	57050546	57050546	+	Silent	SNP	C	C	T			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr19:57050546C>T	ENST00000301318.3	+	1	230	c.159C>T	c.(157-159)ctC>ctT	p.L53L	ZFP28_ENST00000591844.1_Silent_p.L53L|ZFP28_ENST00000594386.1_3'UTR	NM_020828.1	NP_065879.1	Q8NHY6	ZFP28_HUMAN	ZFP28 zinc finger protein	53					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(14)|lung(6)|ovary(1)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	35		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0302)		GGAATGGCCTCGCATCCAAAG	0.697000													5	8					0	0	1	0	0
ERBB3	2065	broad.mit.edu	37	12	56495393	56495393	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr12:56495393G>A	ENST00000267101.3	+	28	4023	c.3583G>A	c.(3583-3585)Gag>Aag	p.E1195K	ERBB3_ENST00000549832.1_Missense_Mutation_p.E315K|ERBB3_ENST00000450146.2_Missense_Mutation_p.E552K|ERBB3_ENST00000415288.2_Missense_Mutation_p.E1136K|RP11-603J24.9_ENST00000548861.1_Intron|ERBB3_ENST00000553131.1_Missense_Mutation_p.E436K	NM_001982.3	NP_001973.2	P21860	ERBB3_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3	1195					cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(2)|lung(3)|ovary(1)|skin(1)|stomach(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			AGATGAAGATGAGGAGTATGA	0.532000													13	38					0	0	1	0	0
GAREM	64762	broad.mit.edu	37	18	29848516	29848516	+	Missense_Mutation	SNP	T	T	A			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr18:29848516T>A	ENST00000399218.4	-	6	2001	c.1946A>T	c.(1945-1947)tAt>tTt	p.Y649F	GAREM_ENST00000269209.6_Missense_Mutation_p.Y650F	NM_001242409.1|NM_022751.2	NP_001229338.1|NP_073588.1			GRB2 associated, regulator of MAPK1																		AGGGTAACTATAACTCCTGCT	0.527000													9	40					0	0	1	0	0
NBPF1	55672	broad.mit.edu	37	1	16895685	16895685	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr1:16895685C>G	ENST00000430580.2	-	23	3384	c.2497G>C	c.(2497-2499)Gat>Cat	p.D833H	NBPF1_ENST00000287968.8_3'UTR|NBPF1_ENST00000420031.2_3'UTR|NBPF1_ENST00000432949.1_Intron	NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1	833	NBPF 4.					cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TAACCTTCATCCCAGGACTCC	0.478000													22	344					0	0	1	0	0
ALOX15	246	broad.mit.edu	37	17	4534988	4534988	+	Silent	SNP	G	G	A			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr17:4534988G>A	ENST00000570836.1	-	15	1992	c.1896C>T	c.(1894-1896)gcC>gcT	p.A632A	ALOX15_ENST00000293761.3_Silent_p.A632A|ALOX15_ENST00000574640.1_Silent_p.A593A|ALOX15_ENST00000545513.1_Silent_p.A654A			P16050	LOX15_HUMAN	arachidonate 15-lipoxygenase	632	Lipoxygenase.				inflammatory response|leukotriene biosynthetic process	nucleus	arachidonate 15-lipoxygenase activity|iron ion binding|lipoxygenase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(5)	20				READ - Rectum adenocarcinoma(115;0.0327)	Ciclopirox(DB01188)|Masoprocol(DB00179)|Zileuton(DB00744)	CCTTATCCAGGGCAGCCAGCT	0.582000													36	124					0	0	1	0	0
FXYD1	5348	broad.mit.edu	37	19	35632082	35632082	+	Silent	SNP	C	C	G			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr19:35632082C>G	ENST00000588081.1	+	3	199	c.141C>G	c.(139-141)ctC>ctG	p.L47L	CTD-2527I21.4_ENST00000592174.1_RNA|FXYD1_ENST00000589209.1_Silent_p.L47L|FXYD1_ENST00000588715.1_Silent_p.L47L|FXYD1_ENST00000588607.1_Silent_p.L47L|LGI4_ENST00000493050.1_Intron|FXYD1_ENST00000455515.2_Silent_p.L47L|FXYD1_ENST00000351325.4_Silent_p.L47L			O00168	PLM_HUMAN	FXYD domain containing ion transport regulator 1	47					muscle contraction	chloride channel complex|integral to plasma membrane	chloride channel activity			lung(3)	3	all_lung(56;7.56e-09)|Lung NSC(56;1.1e-08)|Esophageal squamous(110;0.162)		Epithelial(14;2.32e-21)|OV - Ovarian serous cystadenocarcinoma(14;3.17e-20)|all cancers(14;2.43e-18)|LUSC - Lung squamous cell carcinoma(66;0.0849)			CCGGGATCCTCTTCATCCTGG	0.647000													9	38					0	0	1	0	0
ZNF280B	140883	broad.mit.edu	37	22	22843645	22843645	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr22:22843645C>G	ENST00000360412.2	-	4	854	c.79G>C	c.(79-81)Gat>Cat	p.D27H	ZNF280B_ENST00000406426.1_Missense_Mutation_p.D27H	NM_080764.2	NP_542942.1	Q86YH2	Z280B_HUMAN	zinc finger protein 280B	27					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(9)|ovary(2)	22	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		AGCTCAGCATCTTCGTCATCT	0.373000													35	100					0	0	1	0	0
BCL9L	283149	broad.mit.edu	37	11	118772025	118772025	+	Silent	SNP	G	G	A			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr11:118772025G>A	ENST00000334801.3	-	6	3391	c.2427C>T	c.(2425-2427)ccC>ccT	p.P809P	BCL9L_ENST00000526143.1_5'UTR	NM_182557.2	NP_872363.1	Q86UU0	BCL9L_HUMAN	B-cell CLL/lymphoma 9-like	809	Met-rich.				negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		transcription coactivator activity			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	56	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.66e-05)		TGAGGCCCTGGGGCCCCATCA	0.607000													11	39					0	0	1	0	0
CDKN2A	1029	broad.mit.edu	37	9	21970900	21970900	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr9:21970900C>A	ENST00000497750.1	-	2	379	c.305G>T	c.(304-306)gGt>gTt	p.G102V	CDKN2A_ENST00000498628.2_Splice_Site|CDKN2A_ENST00000578845.2_Splice_Site|CDKN2A_ENST00000479692.2_Splice_Site|CDKN2A_ENST00000530628.2_Intron|RP11-145E5.5_ENST00000404796.2_Intron|CDKN2A_ENST00000494262.1_Splice_Site|CDKN2A_ENST00000579122.1_Intron|CDKN2A_ENST00000446177.1_Splice_Site|CDKN2A_ENST00000304494.5_Splice_Site|CDKN2A_ENST00000361570.3_Splice_Site|CDKN2A_ENST00000498124.1_Splice_Site|CDKN2A_ENST00000579755.1_Splice_Site			P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A	0			A -> E (in LFS; somatic mutation).|A -> T (in dbSNP:rs35741010).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein kinase binding	p.0?(1315)|p.?(12)|p.0(1)		NS(28)|adrenal_gland(6)|autonomic_ganglia(11)|biliary_tract(74)|bone(84)|breast(46)|central_nervous_system(522)|cervix(23)|endometrium(14)|eye(4)|genital_tract(15)|haematopoietic_and_lymphoid_tissue(698)|kidney(39)|large_intestine(11)|liver(92)|lung(365)|meninges(18)|oesophagus(239)|ovary(98)|pancreas(263)|pleura(94)|prostate(13)|salivary_gland(10)|skin(541)|small_intestine(1)|soft_tissue(93)|stomach(48)|thymus(4)|thyroid(24)|upper_aerodigestive_tract(436)|urinary_tract(283)|vulva(2)	4199		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TCAGTCCTCACCTGAGGGACC	0.597000		17								HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			13	26					1.61879e-10	1.81821e-10	1	1	0
ZNF224	7767	broad.mit.edu	37	19	44612185	44612185	+	Silent	SNP	C	C	G			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr19:44612185C>G	ENST00000336976.6	+	6	2126	c.1872C>G	c.(1870-1872)ctC>ctG	p.L624L	AC084219.4_ENST00000592946.1_RNA	NM_013398.2	NP_037530.2	Q9NZL3	ZN224_HUMAN	zinc finger protein 224	624					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(2)|ovary(2)|prostate(1)|stomach(2)|urinary_tract(1)	19		Prostate(69;0.0435)				AAACACCTCTCAAATGTGAGC	0.453000													12	64					0	0	1	0	0
HELZ	9931	broad.mit.edu	37	17	65134094	65134094	+	Missense_Mutation	SNP	T	T	G			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr17:65134094T>G	ENST00000358691.5	-	22	3072	c.2906A>C	c.(2905-2907)aAa>aCa	p.K969T	HELZ_ENST00000580168.1_Missense_Mutation_p.K970T	NM_014877.3	NP_055692.2			helicase with zinc finger											NS(1)|breast(5)|endometrium(9)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					TAATCTCTTTTTTCGAAGTTC	0.383000													20	76					0	0	1	0	0
IL6ST	3572	broad.mit.edu	37	5	55256304	55256304	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr5:55256304C>T	ENST00000381298.2	-	8	1211	c.899G>A	c.(898-900)cGc>cAc	p.R300H	IL6ST_ENST00000502326.3_Missense_Mutation_p.R300H|IL6ST_ENST00000336909.5_Missense_Mutation_p.R300H|IL6ST_ENST00000381286.3_Intron|IL6ST_ENST00000536319.1_Missense_Mutation_p.R300H|IL6ST_ENST00000381287.4_Missense_Mutation_p.R300H|IL6ST_ENST00000522633.2_Missense_Mutation_p.R300H|IL6ST_ENST00000381294.3_Missense_Mutation_p.R300H|IL6ST_ENST00000381293.2_Missense_Mutation_p.R134H	NM_001190981.1|NM_002184.3|NM_175767.2	NP_001177910.1|NP_002175.2|NP_786943.1	P40189	IL6RB_HUMAN	interleukin 6 signal transducer (gp130, oncostatin M receptor)	300	Fibronectin type-III 2.				interleukin-6-mediated signaling pathway|leukemia inhibitory factor signaling pathway|negative regulation of interleukin-6-mediated signaling pathway|positive regulation of anti-apoptosis|positive regulation of cardiac muscle hypertrophy|positive regulation of osteoblast differentiation|positive regulation of T cell proliferation|positive regulation of tyrosine phosphorylation of Stat1 protein|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation vascular endothelial growth factor production	ciliary neurotrophic factor receptor complex|extracellular region|extracellular space|interleukin-6 receptor complex|oncostatin-M receptor complex	ciliary neurotrophic factor receptor activity|ciliary neurotrophic factor receptor binding|growth factor binding|protein homodimerization activity			breast(2)|endometrium(5)|kidney(5)|large_intestine(4)|liver(2)|lung(1)|ovary(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	26		Lung NSC(810;8.69e-05)|Prostate(74;0.00308)|Breast(144;0.0544)|Ovarian(174;0.223)				CTTCATACAGCGAATCCTAAA	0.403000			O		hepatocellular ca								13	37					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113651006	113651006	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr8:113651006G>C	ENST00000297405.5	-	21	3689	c.3445C>G	c.(3445-3447)Ctc>Gtc	p.L1149V	CSMD3_ENST00000352409.3_Missense_Mutation_p.L1149V|CSMD3_ENST00000455883.2_Missense_Mutation_p.L1045V|CSMD3_ENST00000343508.3_Missense_Mutation_p.L1109V	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1149	CUB 6.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						TTTCCATAGAGACCAGCATTG	0.383000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			14	78					0	0	1	0	0
PCDHB6	56130	broad.mit.edu	37	5	140530440	140530440	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr5:140530440G>A	ENST00000231136.1	+	1	602	c.602G>A	c.(601-603)cGc>cAc	p.R201H	PCDHB6_ENST00000543635.1_Missense_Mutation_p.R65H	NM_018939.2	NP_061762.1	Q9Y5E3	PCDB6_HUMAN		201	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding	p.R201H(1)		cervix(1)|endometrium(14)|kidney(6)|large_intestine(16)|liver(1)|lung(33)|ovary(1)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	84			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCGTTGGACCGCGAGGAGCAG	0.602000													20	63					0	0	1	0	0
TMEM246	84302	broad.mit.edu	37	9	104238191	104238191	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr9:104238191C>T	ENST00000374851.1	-	4	2331	c.1184G>A	c.(1183-1185)cGg>cAg	p.R395Q	RP11-490D19.6_ENST00000425734.1_RNA|RP11-490D19.6_ENST00000450109.1_RNA|RP11-490D19.6_ENST00000431507.1_RNA|RP11-490D19.6_ENST00000424154.1_RNA|TMEM246_ENST00000374847.1_Missense_Mutation_p.R395Q|TMEM246_ENST00000374848.3_Missense_Mutation_p.R395Q			Q9BRR3	CI125_HUMAN	transmembrane protein 246	395						integral to membrane											AAAGTTGTACCGGAGACTGGA	0.483000													6	73					0	0	1	0	0
GRIN2B	2904	broad.mit.edu	37	12	13715930	13715930	+	Silent	SNP	C	C	T			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr12:13715930C>T	ENST00000279593.3	-	13	4451	c.4242G>A	c.(4240-4242)gcG>gcA	p.A1414A		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	1414					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TGGCTTTCGACGCCCCCGCCA	0.617000													7	22					0	0	1	0	0
NID2	22795	broad.mit.edu	37	14	52481889	52481889	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr14:52481889C>A	ENST00000216286.5	-	15	3132	c.3133G>T	c.(3133-3135)Gac>Tac	p.D1045Y	NID2_ENST00000541773.1_Missense_Mutation_p.D944Y	NM_007361.3	NP_031387.3	Q14112	NID2_HUMAN	nidogen 2 (osteonidogen)	1045	Thyroglobulin type-1 2.					basement membrane	calcium ion binding|collagen binding			NS(1)|breast(5)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(40)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	87	Breast(41;0.0639)|all_epithelial(31;0.123)					TGGCCCAGGTCATCGCACTGG	0.647000													4	50					0.150653	0.151632	1	1	0
ZFPM2	23414	broad.mit.edu	37	8	106811156	106811156	+	Missense_Mutation	SNP	T	T	A			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr8:106811156T>A	ENST00000407775.2	+	7	1194	c.944T>A	c.(943-945)aTg>aAg	p.M315K	ZFPM2_ENST00000522296.1_3'UTR|RP11-152P17.2_ENST00000520433.1_RNA|ZFPM2_ENST00000378472.4_Missense_Mutation_p.M46K|RP11-152P17.2_ENST00000509144.2_RNA|RP11-152P17.2_ENST00000524045.2_RNA|ZFPM2_ENST00000517361.1_Missense_Mutation_p.M183K|RP11-152P17.2_ENST00000518932.1_RNA|RP11-152P17.2_ENST00000520594.1_RNA|ZFPM2_ENST00000520492.1_Missense_Mutation_p.M183K|RP11-152P17.2_ENST00000521622.1_RNA	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	315					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			GCTCTAGAAATGCACCTGAAT	0.428000													24	96					0	0	1	0	0
PACS1	55690	broad.mit.edu	37	11	66001279	66001279	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr11:66001279C>T	ENST00000320580.4	+	16	1895	c.1862C>T	c.(1861-1863)cCg>cTg	p.P621L	PACS1_ENST00000529757.1_Missense_Mutation_p.P157L	NM_018026.3	NP_060496.2	Q6VY07	PACS1_HUMAN	phosphofurin acidic cluster sorting protein 1	621					interspecies interaction between organisms|regulation of defense response to virus by virus|viral reproduction	cytosol	protein binding		RBM14/PACS1(2)	breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(8)|ovary(6)|skin(2)|urinary_tract(1)	37						TCTTCCATGCCGAGGCCAGTG	0.612000													9	45					0	0	1	0	0
SPI1	6688	broad.mit.edu	37	11	47377022	47377022	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr11:47377022C>A	ENST00000378538.3	-	5	791	c.569G>T	c.(568-570)tGg>tTg	p.W190L	SPI1_ENST00000533030.1_3'UTR|SPI1_ENST00000227163.4_Missense_Mutation_p.W191L	NM_001080547.1|NM_003120.2	NP_001074016.1|NP_003111.2	P17947	SPI1_HUMAN	spleen focus forming virus (SFFV) proviral integration oncogene	190					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of erythrocyte differentiation	nucleus	protein binding|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|large_intestine(2)|lung(4)|ovary(1)	8				Lung(87;0.0967)		GTCCACCCACCAGATGCTGTC	0.632000													6	50					8.12818e-05	8.62924e-05	1	1	0
GLP2R	9340	broad.mit.edu	37	17	9792828	9792828	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr17:9792828C>T	ENST00000262441.5	+	13	1981	c.1468C>T	c.(1468-1470)Ctt>Ttt	p.L490F	GLP2R_ENST00000574745.1_Missense_Mutation_p.L310F	NM_004246.1	NP_004237.1	O95838	GLP2R_HUMAN	glucagon-like peptide 2 receptor	490					G-protein signaling, coupled to cAMP nucleotide second messenger|positive regulation of cell proliferation	integral to membrane|plasma membrane				endometrium(4)|large_intestine(7)|lung(22)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	44					Glucagon recombinant(DB00040)	CGCTGAGAAGCTTCGGAAGCT	0.612000													41	47					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237817654	237817654	+	Missense_Mutation	SNP	A	A	C			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr1:237817654A>C	ENST00000366574.2	+	52	8222	c.7905A>C	c.(7903-7905)gaA>gaC	p.E2635D	RYR2_ENST00000360064.6_Missense_Mutation_p.E2633D|RYR2_ENST00000542537.1_Missense_Mutation_p.E2619D	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	2635	4 X approximate repeats.|Modulator (Potential).				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CTGCCTCAGAAGAAGAACTTC	0.383000													6	27					0	0	1	0	0
SLFN12	55106	broad.mit.edu	37	17	33749590	33749590	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr17:33749590C>G	ENST00000394562.1	-	4	981	c.458G>C	c.(457-459)aGa>aCa	p.R153T	SLFN12_ENST00000304905.5_Missense_Mutation_p.R153T|SLFN12_ENST00000452764.3_Missense_Mutation_p.R153T			Q8IYM2	SLN12_HUMAN	schlafen family member 12	153							ATP binding			breast(1)|kidney(2)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	18		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CAATCTCCCTCTAGTCTTTTT	0.408000													9	60					0	0	1	0	0
ZNF2	7549	broad.mit.edu	37	2	95846949	95846949	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr2:95846949G>C	ENST00000398107.2	+	4	772	c.250G>C	c.(250-252)Gaa>Caa	p.E84Q	ZNF2_ENST00000340539.5_Missense_Mutation_p.E126Q|ZNF2_ENST00000295210.6_Missense_Mutation_p.E88Q|ZNF2_ENST00000453539.2_Missense_Mutation_p.E139Q|ZNF2_ENST00000425369.1_Missense_Mutation_p.E46Q	NM_001017396.1	NP_001017396.1	Q9BSG1	ZNF2_HUMAN	zinc finger protein 2	126	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|large_intestine(4)|lung(3)|upper_aerodigestive_tract(1)	12		Ovarian(717;0.00768)		READ - Rectum adenocarcinoma(193;0.0222)		TCCTAAATTTGAAGTTCATAC	0.493000													5	86					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62291818	62291818	+	Silent	SNP	A	A	G			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr11:62291818A>G	ENST00000378024.4	-	5	10345	c.10071T>C	c.(10069-10071)ttT>ttC	p.F3357F	AHNAK_ENST00000530124.1_Intron|AHNAK_ENST00000257247.7_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	3357					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				CCGAAAAATTAAATTTGGGAA	0.403000													6	95					0	0	1	0	0
INPP5F	22876	broad.mit.edu	37	10	121586558	121586558	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr10:121586558C>G	ENST00000361976.2	+	20	2831	c.2665C>G	c.(2665-2667)Ctt>Gtt	p.L889V	INPP5F_ENST00000369080.3_Missense_Mutation_p.L279V	NM_014937.3	NP_055752.1	Q9Y2H2	SAC2_HUMAN	inositol polyphosphate-5-phosphatase F	889							phosphoric ester hydrolase activity			breast(1)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(9)|lung(5)|ovary(5)|pancreas(1)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	42		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00205)|BRCA - Breast invasive adenocarcinoma(275;0.158)		AGATTACGTTCTTCCTAGTTG	0.453000													18	73					0	0	1	0	0
TMCC2	9911	broad.mit.edu	37	1	205210900	205210900	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr1:205210900C>T	ENST00000358024.3	+	2	864	c.475C>T	c.(475-477)Ccc>Tcc	p.P159S	TMCC2_ENST00000495538.1_3'UTR|TMCC2_ENST00000545499.1_Missense_Mutation_p.P81S	NM_014858.3	NP_055673.2	O75069	TMCC2_HUMAN	transmembrane and coiled-coil domain family 2	159						integral to membrane	protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|liver(2)|lung(3)|pancreas(1)|skin(1)|urinary_tract(1)	20	Breast(84;0.0871)		BRCA - Breast invasive adenocarcinoma(75;0.117)			CCGCTCCCGGCCCTCCATCAA	0.716000													7	18					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179428531	179428531	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr2:179428531C>T	ENST00000589042.1	-	326	82552	c.82328G>A	c.(82327-82329)cGt>cAt	p.R27443H	TTN_ENST00000460472.2_Missense_Mutation_p.R18378H|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.R18570H|TTN_ENST00000591111.1_Missense_Mutation_p.R25802H|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.R24875H|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.R18503H	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	25802							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGCCATGACACGGAAAATGTA	0.473000													18	86					0	0	1	0	0
USP6	9098	broad.mit.edu	37	17	5072206	5072206	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr17:5072206C>A	ENST00000574788.1	+	35	5603	c.3373C>A	c.(3373-3375)Ccc>Acc	p.P1125T	USP6_ENST00000304328.5_Missense_Mutation_p.P808T|USP6_ENST00000332776.4_3'UTR|USP6_ENST00000250066.6_Missense_Mutation_p.P1125T			P35125	UBP6_HUMAN	ubiquitin specific peptidase 6 (Tre-2 oncogene)	1125					protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	34						ACCACTCACACCCCAGGGGGA	0.502000			T	"""COL1A1, CDH11, ZNF9, OMD"""	aneurysmal bone cysts								66	69					2.26907e-38	2.68477e-38	1	1	0
FANCM	57697	broad.mit.edu	37	14	45658278	45658278	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr14:45658278G>C	ENST00000267430.5	+	20	5138	c.5053G>C	c.(5053-5055)Gaa>Caa	p.E1685Q	FANCM_ENST00000542564.2_Missense_Mutation_p.E1659Q	NM_020937.2	NP_065988.1	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	1685					DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(31)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	85						TGATAAAAGAGAATCTAATAT	0.353000								Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				4	72					0	0	1	0	0
LRCH3	84859	broad.mit.edu	37	3	197556504	197556504	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr3:197556504C>G	ENST00000438796.2	+	6	891	c.847C>G	c.(847-849)Ctg>Gtg	p.L283V	LRCH3_ENST00000414675.2_Missense_Mutation_p.L283V|LRCH3_ENST00000334859.4_Missense_Mutation_p.L283V|LRCH3_ENST00000536618.1_5'UTR|LRCH3_ENST00000425562.2_Missense_Mutation_p.L283V|LRCH3_ENST00000441090.2_Missense_Mutation_p.L157V			Q96II8	LRCH3_HUMAN	leucine-rich repeats and calponin homology (CH) domain containing 3	283						extracellular region				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;4.82e-24)|all cancers(36;3.61e-22)|OV - Ovarian serous cystadenocarcinoma(49;7.08e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.119)		TGCTCCAGATCTGCCGGATTA	0.348000													4	75					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25436596	25436596	+	RNA	SNP	G	G	C			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr15:25436596G>C	ENST00000424208.1	+	0	1092				SNHG14_ENST00000414175.1_RNA|SNORD115-12_ENST00000362583.1_RNA	NR_003305.1																						TTGTCCTGAAGAGAGGTGATG	0.527000													14	437					0	0	1	0	0
NFATC2IP	84901	broad.mit.edu	37	16	28967572	28967572	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr16:28967572G>A	ENST00000320805.4	+	5	835	c.760G>A	c.(760-762)Gaa>Aaa	p.E254K	NFATC2IP_ENST00000564978.1_Intron|NFATC2IP_ENST00000562977.1_Intron	NM_032815.3	NP_116204.3	Q8NCF5	NF2IP_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein	254						cytoplasm|nucleus				breast(1)|endometrium(2)|large_intestine(1)|lung(5)|ovary(2)	11						GGTCTTGGTGGAAGGGCCCAC	0.607000													7	37					0	0	1	0	0
HEATR1	55127	broad.mit.edu	37	1	236717934	236717934	+	Silent	SNP	C	C	T			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr1:236717934C>T	ENST00000366582.3	-	42	6156	c.6042G>A	c.(6040-6042)gaG>gaA	p.E2014E	HEATR1_ENST00000366581.2_Silent_p.E1933E	NM_018072.5	NP_060542.4	Q9H583	HEAT1_HUMAN	HEAT repeat containing 1	2014					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(18)|lung(28)|ovary(3)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	87	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			CTTCTGCTCTCTCTTTACTTA	0.408000													15	71					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577058	7577058	+	Nonsense_Mutation	SNP	C	C	A			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr17:7577058C>A	ENST00000420246.2	-	8	1012	c.880G>T	c.(880-882)Gag>Tag	p.E294*	TP53_ENST00000445888.2_Nonsense_Mutation_p.E294*|TP53_ENST00000269305.4_Nonsense_Mutation_p.E294*|TP53_ENST00000413465.2_Intron|TP53_ENST00000359597.4_Nonsense_Mutation_p.E294*|TP53_ENST00000455263.2_Nonsense_Mutation_p.E294*	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	294	Interaction with E4F1.|Interaction with HIPK1 (By similarity).		E -> A (in a sporadic cancer; somatic mutation).|E -> D (in sporadic cancers; somatic mutation).|E -> G (in sporadic cancers; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).|E -> Q (in sporadic cancers; somatic mutation).|E -> V (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E294*(46)|p.E294fs*51(9)|p.K291fs*48(8)|p.0?(8)|p.E294K(3)|p.E294fs*12(3)|p.?(2)|p.E294Q(2)|p.L265_K305del41(1)|p.E294>*(1)|p.G293fs*1(1)|p.R290fs*50(1)|p.R290_P295>X(1)|p.E294fs*11(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGGTGAGGCTCCCCTTTCTTG	0.567000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			23	37					1.42536e-11	1.61263e-11	1	1	0
GIT1	28964	broad.mit.edu	37	17	27903261	27903261	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr17:27903261G>A	ENST00000225394.3	-	14	1836	c.1588C>T	c.(1588-1590)Cgg>Tgg	p.R530W	GIT1_ENST00000581348.1_Missense_Mutation_p.R539W|GIT1_ENST00000394869.3_Missense_Mutation_p.R539W|GIT1_ENST00000579937.1_Missense_Mutation_p.R530W|RP11-68I3.2_ENST00000581474.1_RNA	NM_014030.3	NP_054749.2	Q9Y2X7	GIT1_HUMAN	G protein-coupled receptor kinase interacting ArfGAP 1	530					regulation of ARF GTPase activity|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|focal adhesion	ARF GTPase activator activity|protein binding|zinc ion binding			large_intestine(2)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	9				READ - Rectum adenocarcinoma(3;0.0419)|Colorectal(3;0.069)		GGCTGCAGCCGCGTAGTGAGC	0.642000													37	98					0	0	1	0	0
UAP1	6675	broad.mit.edu	37	1	162546694	162546694	+	Missense_Mutation	SNP	T	T	G			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr1:162546694T>G	ENST00000271469.3	+	3	710	c.408T>G	c.(406-408)ttT>ttG	p.F136L	UAP1_ENST00000367926.4_Missense_Mutation_p.F136L|UAP1_ENST00000367924.1_Missense_Mutation_p.F136L|UAP1_ENST00000367925.1_Missense_Mutation_p.F136L			Q16222	UAP1_HUMAN	UDP-N-acteylglucosamine pyrophosphorylase 1	136					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol|nucleus|plasma membrane	UDP-N-acetylglucosamine diphosphorylase activity			breast(2)|cervix(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(2)|skin(2)|stomach(1)	22	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.126)			AGACACTTTTTCAGATTCAAG	0.438000													8	88					0	0	1	0	0
ECI2	10455	broad.mit.edu	37	6	4133832	4133832	+	Missense_Mutation	SNP	T	T	C			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr6:4133832T>C	ENST00000465828.1	-	2	359	c.74A>G	c.(73-75)aAg>aGg	p.K25R	ECI2_ENST00000380118.3_Missense_Mutation_p.K55R|ECI2_ENST00000413766.2_5'UTR|ECI2_ENST00000361538.2_Missense_Mutation_p.K25R|ECI2_ENST00000380125.2_Missense_Mutation_p.K25R			O75521	ECI2_HUMAN	enoyl-CoA delta isomerase 2	55					fatty acid metabolic process	mitochondrion|peroxisomal matrix	dodecenoyl-CoA delta-isomerase activity|fatty-acyl-CoA binding			endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(1)	11						TCCTGGATCCTTTTTCAAGAG	0.398000													4	126					0	0	1	0	0
SLC4A5	57835	broad.mit.edu	37	2	74454158	74454158	+	Missense_Mutation	SNP	G	G	C	rs146665416	byFrequency	TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr2:74454158G>C	ENST00000394019.2	-	27	3413	c.3016C>G	c.(3016-3018)Ctg>Gtg	p.L1006V	SLC4A5_ENST00000377634.4_Missense_Mutation_p.L1022V|SLC4A5_ENST00000358683.4_Missense_Mutation_p.L904V|SLC4A5_ENST00000346834.4_Intron|SLC4A5_ENST00000423644.1_Missense_Mutation_p.P946R|SLC4A5_ENST00000359484.4_Missense_Mutation_p.L904V|SLC4A5_ENST00000357822.5_Missense_Mutation_p.L1022V|SLC4A5_ENST00000377632.1_Intron|SLC4A5_ENST00000483195.1_5'UTR|RP11-287D1.3_ENST00000451608.2_3'UTR	NM_133478.2	NP_597812.1	Q9BY07	S4A5_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 5	1022						apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			breast(5)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(13)|ovary(5)|pancreas(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						ATCTGCACCAGGGTGAAGAGG	0.632000													12	69					0	0	1	0	0
GRAP2	9402	broad.mit.edu	37	22	40365485	40365485	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr22:40365485C>T	ENST00000344138.4	+	7	1024	c.761C>T	c.(760-762)gCg>gTg	p.A254V	GRAP2_ENST00000399090.2_Missense_Mutation_p.A141V|GRAP2_ENST00000543252.1_Missense_Mutation_p.A214V|GRAP2_ENST00000407075.3_Missense_Mutation_p.A254V|GRAP2_ENST00000540310.1_Missense_Mutation_p.A188V|GRAP2_ENST00000544756.1_Missense_Mutation_p.A182V	NM_004810.2	NP_004801.1	O75791	GRAP2_HUMAN	GRB2-related adaptor protein 2	254					cell-cell signaling|Ras protein signal transduction|T cell costimulation|T cell receptor signaling pathway	cytosol	SH3/SH2 adaptor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	14						GAAATGAATGCGGCCCTCATG	0.572000													4	62					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	142004875	142004875	+	Missense_Mutation	SNP	T	T	C			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr2:142004875T>C	ENST00000389484.3	-	5	1483	c.512A>G	c.(511-513)aAc>aGc	p.N171S		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	171	EGF-like 2; calcium-binding (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TCCATGTGTGTTTCTGCAGGT	0.403000										TSP Lung(27;0.18)			20	76					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56716356	56716356	+	Missense_Mutation	SNP	T	T	C			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr6:56716356T>C	ENST00000370754.5	-	4	463	c.464A>G	c.(463-465)gAt>gGt	p.D155G	RP11-472M19.2_ENST00000426453.1_RNA			Q03001	DYST_HUMAN	dystonin	0	Actin-binding.|CH 2.				cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			ATCGGAAAAATCCGCAGAGGA	0.473000											OREG0017515	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	23					0	0	1	0	0
AGMO	392636	broad.mit.edu	37	7	15599873	15599873	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr7:15599873C>G	ENST00000342526.3	-	2	319	c.150G>C	c.(148-150)ttG>ttC	p.L50F		NM_001004320.1	NP_001004320.1	Q6ZNB7	ALKMO_HUMAN	alkylglycerol monooxygenase	50					ether lipid metabolic process|fatty acid biosynthetic process|membrane lipid metabolic process	endoplasmic reticulum membrane|integral to membrane	glyceryl-ether monooxygenase activity|iron ion binding			breast(1)|kidney(1)|large_intestine(6)|liver(1)|lung(30)|prostate(1)|skin(2)	42						CAAGCAGCATCAAAGAAATGA	0.403000													14	66					0	0	1	0	0
LSM14B	149986	broad.mit.edu	37	20	60705703	60705703	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr20:60705703G>A	ENST00000253001.4	+	6	997	c.791G>A	c.(790-792)cGa>cAa	p.R264Q	LSM14B_ENST00000279068.6_Missense_Mutation_p.R264Q			Q9BX40	LS14B_HUMAN	LSM14B, SCD6 homolog B (S. cerevisiae)	264	DFDF.				multicellular organismal development|regulation of translation	ribonucleoprotein complex				endometrium(3)|kidney(1)|lung(4)	8	Breast(26;3.97e-09)		BRCA - Breast invasive adenocarcinoma(19;1.28e-07)			CAGTTCAACCGAGAGGAGCTT	0.398000													8	26					0	0	1	0	0
PDE2A	5138	broad.mit.edu	37	11	72295279	72295279	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr11:72295279G>A	ENST00000334456.5	-	19	1861	c.1616C>T	c.(1615-1617)gCc>gTc	p.A539V	PDE2A_ENST00000418754.2_Missense_Mutation_p.A424V|PDE2A_ENST00000540345.1_Missense_Mutation_p.A530V|PDE2A_ENST00000376450.3_Missense_Mutation_p.A283V|PDE2A_ENST00000444035.2_Missense_Mutation_p.A530V|PDE2A_ENST00000544570.1_Missense_Mutation_p.A532V	NM_002599.4	NP_002590.1	O00408	PDE2A_HUMAN	phosphodiesterase 2A, cGMP-stimulated	539	GAF 2.				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity|metal ion binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(2)|lung(21)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	36			BRCA - Breast invasive adenocarcinoma(5;3.55e-05)		Sildenafil(DB00203)|Sulindac(DB00605)	GATGGAGAAGGCCGTCGCCAG	0.637000													10	26					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113668571	113668571	+	Splice_Site	SNP	C	C	A			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr8:113668571C>A	ENST00000297405.5	-	18	3061		c.e18-1		CSMD3_ENST00000352409.3_Splice_Site|CSMD3_ENST00000455883.2_Splice_Site|CSMD3_ENST00000343508.3_Splice_Site	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3							integral to membrane|plasma membrane		p.?(2)		breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						AGTCTGAAATCTAAGATTAAA	0.338000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			11	43					0.000978159	0.00100407	1	1	0
HMBS	3145	broad.mit.edu	37	11	118963891	118963891	+	Silent	SNP	G	G	A			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr11:118963891G>A	ENST00000537841.1	+	14	1224	c.933G>A	c.(931-933)caG>caA	p.Q311Q	HMBS_ENST00000392841.1_Silent_p.Q311Q|HMBS_ENST00000278715.3_Silent_p.Q328Q|HMBS_ENST00000544387.1_Silent_p.Q288Q|HMBS_ENST00000442944.2_Silent_p.Q311Q|HMBS_ENST00000542729.1_Silent_p.Q271Q|HMBS_ENST00000543090.1_Silent_p.Q297Q			P08397	HEM3_HUMAN	hydroxymethylbilane synthase	328					peptidyl-pyrromethane cofactor linkage	cytosol	hydroxymethylbilane synthase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|urinary_tract(1)	15	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.72e-05)		GAGGGCCCCAGTTGGCTGCCC	0.542000													23	62					0	0	1	0	0
KRT14	3861	broad.mit.edu	37	17	39740159	39740159	+	Silent	SNP	C	C	G			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr17:39740159C>G	ENST00000167586.6	-	4	866	c.780G>C	c.(778-780)ctG>ctC	p.L260L		NM_000526.4	NP_000517.2	P02533	K1C14_HUMAN	keratin 14	260	Coil 1B.|Rod.				epidermis development|hemidesmosome assembly|intermediate filament bundle assembly	cytosol|keratin filament|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(5)|large_intestine(3)|lung(7)|ovary(1)|prostate(5)|skin(1)|stomach(1)	25		Breast(137;0.000307)				CCTGGCCTCTCAGGGCATTCA	0.577000													4	79					0	0	1	0	0
SMTNL2	342527	broad.mit.edu	37	17	4510712	4510712	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr17:4510712G>A	ENST00000389313.4	+	8	1383	c.1316G>A	c.(1315-1317)cGc>cAc	p.R439H	SMTNL2_ENST00000338859.4_Missense_Mutation_p.R295H	NM_001114974.1	NP_001108446.1	Q2TAL5	SMTL2_HUMAN	smoothelin-like 2	439	CH.									breast(1)|endometrium(9)|kidney(1)|lung(1)|skin(1)	13				READ - Rectum adenocarcinoma(115;0.0325)		GTGATGGGCCGCAAGCCGGAC	0.582000													4	171					0	0	1	0	0
NCAM1	4684	broad.mit.edu	37	11	113126633	113126633	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr11:113126633G>A	ENST00000316851.7	+	14	1833	c.1833G>A	c.(1831-1833)atG>atA	p.M611I	NCAM1_ENST00000533760.1_Missense_Mutation_p.M493I|NCAM1_ENST00000397957.4_3'UTR	NM_001242607.1|NM_181351.4	NP_001229536.1|NP_851996.2	P13591	NCAM1_HUMAN	neural cell adhesion molecule 1	621	Fibronectin type-III 2.				axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(27)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)	49		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		AAGGGCAGATGGGAGAGGATG	0.502000													4	13					0	0	1	0	0
GPR141	353345	broad.mit.edu	37	7	37780629	37780629	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr7:37780629C>T	ENST00000447769.1	+	4	923	c.634C>T	c.(634-636)Cgc>Tgc	p.R212C	GPR141_ENST00000461610.1_Intron|GPR141_ENST00000334425.1_Missense_Mutation_p.R212C|EPDR1_ENST00000476620.1_Intron			Q7Z602	GP141_HUMAN	G protein-coupled receptor 141	212						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(13)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						GCAGAAGCTACGCCACTCTTT	0.413000													23	121					0	0	1	0	0
BTN2A3P	54718	broad.mit.edu	37	6	26423441	26423441	+	RNA	SNP	C	C	G			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr6:26423441C>G	ENST00000466808.2	+	0	360																											ATAACGGCATCTACCAGTGTT	0.527000													15	55					0	0	1	0	0
FGFR2	2263	broad.mit.edu	37	10	123276852	123276852	+	Silent	SNP	T	T	C			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr10:123276852T>C	ENST00000358487.5	-	8	1337	c.1065A>G	c.(1063-1065)gcA>gcG	p.A355A	FGFR2_ENST00000346997.2_Silent_p.A355A|FGFR2_ENST00000369056.1_Intron|FGFR2_ENST00000360144.3_Intron|FGFR2_ENST00000351936.6_Silent_p.A355A|FGFR2_ENST00000369059.1_Intron|FGFR2_ENST00000457416.2_Intron|FGFR2_ENST00000356226.4_Silent_p.A240A|FGFR2_ENST00000369061.4_Intron|FGFR2_ENST00000490349.1_5'UTR|FGFR2_ENST00000478859.1_Silent_p.A127A|FGFR2_ENST00000369060.4_Intron|FGFR2_ENST00000357555.5_Silent_p.A266A	NM_000141.4	NP_000132.3	P21802	FGFR2_HUMAN	fibroblast growth factor receptor 2	355	Ig-like C2-type 3.				angiogenesis|axonogenesis|bone mineralization|bone morphogenesis|branch elongation involved in salivary gland morphogenesis|branching involved in embryonic placenta morphogenesis|branching morphogenesis of a nerve|bud elongation involved in lung branching|cell fate commitment|cell growth|cell-cell signaling|cellular response to protein stimulus|embryonic digestive tract morphogenesis|embryonic pattern specification|epithelial cell proliferation involved in salivary gland morphogenesis|fibroblast growth factor receptor signaling pathway involved in hemopoiesis|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow|fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development|fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow|hair follicle morphogenesis|insulin receptor signaling pathway|lacrimal gland development|lateral sprouting from an epithelium|limb bud formation|lung alveolus development|lung lobe morphogenesis|lung-associated mesenchyme development|mammary gland bud formation|membranous septum morphogenesis|mesenchymal cell differentiation involved in lung development|mesenchymal cell proliferation involved in lung development|midbrain development|multicellular organism growth|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|organ growth|otic vesicle formation|outflow tract septum morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell cycle|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of ERK1 and ERK2 cascade|positive regulation of mesenchymal cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|prostate epithelial cord elongation|pyramidal neuron development|regulation of branching involved in prostate gland morphogenesis|regulation of cell fate commitment|regulation of fibroblast growth factor receptor signaling pathway|regulation of multicellular organism growth|regulation of smooth muscle cell differentiation|regulation of smoothened signaling pathway|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development|ureteric bud development|ventricular cardiac muscle tissue morphogenesis|ventricular zone neuroblast division	cell cortex|cell surface|excitatory synapse|extracellular region|integral to membrane|nucleus|plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|heparin binding|protein binding			breast(3)|central_nervous_system(3)|cervix(2)|endometrium(98)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(7)|lung(21)|ovary(4)|skin(30)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(2)	181		Lung NSC(174;0.0841)|all_lung(145;0.106)|all_neural(114;0.107)	STAD - Stomach adenocarcinoma(1;7.52e-05)|all cancers(1;0.0722)	all cancers(201;9.73e-05)|GBM - Glioblastoma multiforme(135;0.0845)	Palifermin(DB00039)	CTGTCAACCATGCAGAGTGAA	0.403000		5	Mis		"""gastric. NSCLC, endometrial"""		"""Crouzon, Pfeiffer, and Apert syndromes"""		Saethre-Chotzen syndrome;Apert syndrome				5	46					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121420792	121420792	+	Silent	SNP	G	G	A			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr11:121420792G>A	ENST00000260197.7	+	15	2304	c.2175G>A	c.(2173-2175)acG>acA	p.T725T		NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	725					cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		ACAGGAGAACGAGAGGGTATG	0.502000													8	31					0	0	1	0	0
KRT31	3881	broad.mit.edu	37	17	39551731	39551731	+	Nonsense_Mutation	SNP	G	G	A			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr17:39551731G>A	ENST00000251645.2	-	4	785	c.733C>T	c.(733-735)Caa>Taa	p.Q245*		NM_002277.2	NP_002268.2	Q15323	K1H1_HUMAN	keratin 31	245	Coil 2.|Rod.				epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(7)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	31		Breast(137;0.000496)				GTGAACCATTGCTCCACTTCC	0.632000													15	82					0	0	1	0	0
TACC3	10460	broad.mit.edu	37	4	1730043	1730043	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr4:1730043C>A	ENST00000313288.4	+	4	1020	c.914C>A	c.(913-915)aCc>aAc	p.T305N		NM_006342.2	NP_006333.1	Q9Y6A5	TACC3_HUMAN	transforming, acidic coiled-coil containing protein 3	305						centrosome				central_nervous_system(1)|endometrium(4)|large_intestine(1)|lung(10)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	25		Breast(71;0.212)|all_epithelial(65;0.241)	OV - Ovarian serous cystadenocarcinoma(23;0.00765)|Epithelial(3;0.0126)			ACAGCCCCAACCAACCACCTG	0.637000													7	48					0.0381472	0.0386459	1	1	0
SPEN	23013	broad.mit.edu	37	1	16260177	16260177	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr1:16260177C>T	ENST00000375759.3	+	11	7646	c.7442C>T	c.(7441-7443)tCa>tTa	p.S2481L		NM_015001.2	NP_055816.2	Q96T58	MINT_HUMAN	spen family transcriptional repressor	2481	Pro-rich.|RID.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(5)|endometrium(16)|kidney(18)|large_intestine(27)|liver(2)|lung(37)|ovary(7)|prostate(7)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	149		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		GCAAAGCTCTCACCTCCTGTC	0.582000													25	93					0	0	1	0	0
RAB3GAP2	25782	broad.mit.edu	37	1	220364494	220364494	+	Missense_Mutation	SNP	T	T	C			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr1:220364494T>C	ENST00000358951.2	-	14	1519	c.1403A>G	c.(1402-1404)tAt>tGt	p.Y468C		NM_012414.3	NP_036546.2	Q9H2M9	RBGPR_HUMAN	RAB3 GTPase activating protein subunit 2 (non-catalytic)	468					intracellular protein transport	cytoplasm|soluble fraction	GTPase activator activity|protein heterodimerization activity			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(4)|skin(1)|urinary_tract(1)	39				GBM - Glioblastoma multiforme(131;0.0443)		TCTTGGCGCATAGATCACAAG	0.483000													15	67					0	0	1	0	0
GPR50	9248	broad.mit.edu	37	X	150349760	150349760	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chrX:150349760G>T	ENST00000218316.3	+	2	1774	c.1705G>T	c.(1705-1707)Gct>Tct	p.A569S		NM_004224.3	NP_004215.2	Q13585	MTR1L_HUMAN	G protein-coupled receptor 50	569	Pro-rich.				cell-cell signaling	integral to plasma membrane	melatonin receptor activity			breast(4)|central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(6)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|stomach(1)	38	Acute lymphoblastic leukemia(192;6.56e-05)					TAGCCCTGCCGCTGGGCCCAC	0.602000													28	27					8.24728e-16	9.4691e-16	1	1	0
KCNG1	3755	broad.mit.edu	37	20	49620823	49620823	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr20:49620823G>A	ENST00000371571.4	-	3	1580	c.1295C>T	c.(1294-1296)cCc>cTc	p.P432L	RP5-955M13.4_ENST00000424566.1_RNA|RP5-955M13.3_ENST00000506387.1_RNA	NM_002237.3	NP_002228.2	Q9UIX4	KCNG1_HUMAN	potassium voltage-gated channel, subfamily G, member 1	432						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(11)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	35						GGTGCTCCTGGGGACCATGTC	0.637000													21	57					0	0	1	0	0
ALDH16A1	126133	broad.mit.edu	37	19	49964134	49964134	+	Silent	SNP	G	G	A			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr19:49964134G>A	ENST00000293350.4	+	5	718	c.555G>A	c.(553-555)agG>agA	p.R185R	ALDH16A1_ENST00000455361.2_Silent_p.R185R|ALDH16A1_ENST00000433981.2_Silent_p.R20R|ALDH16A1_ENST00000540132.1_Silent_p.R22R	NM_153329.3	NP_699160.2	Q8IZ83	A16A1_HUMAN	aldehyde dehydrogenase 16 family, member A1	185							oxidoreductase activity|protein binding			cervix(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(5)|skin(2)|urinary_tract(3)	20		all_lung(116;5.39e-06)|Lung NSC(112;1.97e-05)|all_neural(266;0.0966)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00156)|GBM - Glioblastoma multiforme(486;0.0251)		TGATGTGGAGGATTTGCCCTG	0.542000													21	58					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126411348	126411348	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr4:126411348C>A	ENST00000394329.3	+	17	13384	c.13371C>A	c.(13369-13371)caC>caA	p.H4457Q	FAT4_ENST00000335110.5_Missense_Mutation_p.H2698Q	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	4457	EGF-like 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						CAGACTCGCACACGGGAAGGA	0.632000													14	92					0.000219431	0.00022981	1	1	0
TACC3	10460	broad.mit.edu	37	4	1730058	1730058	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr4:1730058C>A	ENST00000313288.4	+	4	1035	c.929C>A	c.(928-930)gCt>gAt	p.A310D		NM_006342.2	NP_006333.1	Q9Y6A5	TACC3_HUMAN	transforming, acidic coiled-coil containing protein 3	310						centrosome				central_nervous_system(1)|endometrium(4)|large_intestine(1)|lung(10)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	25		Breast(71;0.212)|all_epithelial(65;0.241)	OV - Ovarian serous cystadenocarcinoma(23;0.00765)|Epithelial(3;0.0126)			CACCTGGTGGCTGGCAGGGCC	0.597000													7	48					0.27861	0.27861	1	1	0
RNF139	11236	broad.mit.edu	37	8	125498293	125498293	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr8:125498293C>G	ENST00000303545.3	+	2	775	c.403C>G	c.(403-405)Cta>Gta	p.L135V		NM_007218.3	NP_009149.2	Q8WU17	RN139_HUMAN	ring finger protein 139	135					negative regulation of cell proliferation|regulation of protein ubiquitination	endoplasmic reticulum membrane|integral to membrane	protein binding|receptor activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|liver(1)|lung(4)|prostate(1)|skin(1)	20	Ovarian(258;0.00438)|all_neural(195;0.0779)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			CGTTCTACAGCTAACATTTGG	0.413000													8	102					0	0	1	0	0
TAS2R31	259290	broad.mit.edu	37	12	11183589	11183589	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr12:11183589G>A	ENST00000390675.2	-	1	417	c.346C>T	c.(346-348)Ctt>Ttt	p.L116F	TAS2R14_ENST00000381852.4_Intron|PRR4_ENST00000536668.1_Intron	NM_176885.2	NP_795366.2	P59538	T2R31_HUMAN	taste receptor, type 2, member 31	116					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			kidney(1)|lung(6)	7						AGAAAAATAAGGTTGGAGAAA	0.393000													4	108					0	0	1	0	0
KRTAP12-4	386684	broad.mit.edu	37	21	46074226	46074226	+	Missense_Mutation	SNP	T	T	A			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr21:46074226T>A	ENST00000391618.1	-	1	350	c.306A>T	c.(304-306)agA>agT	p.R102S	TSPEAR_ENST00000323084.4_Intron	NM_198698.1	NP_941971.1	P60329	KR124_HUMAN	keratin associated protein 12-4	102						keratin filament				lung(4)|ovary(1)|prostate(1)	6						AGGTGACAGGTCTATAGACCA	0.617000													12	52					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228451984	228451984	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr1:228451984G>T	ENST00000570156.2	+	18	5379	c.5305G>T	c.(5305-5307)Gtg>Ttg	p.V1769L	OBSCN_ENST00000366707.4_5'UTR|OBSCN_ENST00000422127.1_Missense_Mutation_p.V1585L|OBSCN_ENST00000284548.11_Missense_Mutation_p.V1585L|OBSCN_ENST00000366709.4_5'UTR|OBSCN_ENST00000359599.6_Missense_Mutation_p.V241L	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	757	Fibronectin type-III 2.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				AATGGAGGCCGTGGGCTGCAC	0.662000													26	73					1.66031e-10	1.85142e-10	1	1	0
PHF3	23469	broad.mit.edu	37	6	64416061	64416061	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr6:64416061C>A	ENST00000262043.3	+	12	3850	c.3510C>A	c.(3508-3510)ttC>ttA	p.F1170L	PHF3_ENST00000393387.1_Missense_Mutation_p.F1170L			Q92576	PHF3_HUMAN	PHD finger protein 3	1170					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			breast(7)|cervix(2)|endometrium(8)|kidney(7)|large_intestine(18)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(6)	75	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			CTTCTGAATTCTTTGAGGAGG	0.373000													6	47					0.00116845	0.00119151	1	1	0
MINPP1	9562	broad.mit.edu	37	10	89280889	89280889	+	Missense_Mutation	SNP	T	T	C			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr10:89280889T>C	ENST00000371996.4	+	4	1071	c.1030T>C	c.(1030-1032)Ttt>Ctt	p.F344L	MINPP1_ENST00000472891.1_3'UTR|MINPP1_ENST00000371994.4_Intron|MINPP1_ENST00000536010.1_Missense_Mutation_p.F143L	NM_004897.4	NP_004888.2	Q9UNW1	MINP1_HUMAN	multiple inositol-polyphosphate phosphatase 1	344				F -> S (in Ref. 3; CAB43673).	bone mineralization|polyphosphate metabolic process	endoplasmic reticulum lumen	acid phosphatase activity|bisphosphoglycerate 3-phosphatase activity|multiple inositol-polyphosphate phosphatase activity|phosphohistidine phosphatase activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|urinary_tract(2)	5		Colorectal(252;0.122)		UCEC - Uterine corpus endometrioid carcinoma (6;0.00123)		TCAGGATATCTTTCAGCACTT	0.318000													4	129					0	0	1	0	0
OR10G9	219870	broad.mit.edu	37	11	123894176	123894176	+	Silent	SNP	C	C	T			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr11:123894176C>T	ENST00000375024.1	+	1	457	c.457C>T	c.(457-459)Ctg>Ttg	p.L153L		NM_001001953.1	NP_001001953.1	Q8NGN4	O10G9_HUMAN	olfactory receptor, family 10, subfamily G, member 9	153					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.L153V(1)		breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(33)|prostate(2)|skin(4)|stomach(8)|urinary_tract(1)	61		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		CAGTGGCTCTCTGCACTCTGC	0.542000													28	106					0	0	1	0	0
NPAS4	266743	broad.mit.edu	37	11	66188698	66188698	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr11:66188698C>G	ENST00000311034.2	+	1	224	c.48C>G	c.(46-48)atC>atG	p.I16M		NM_178864.3	NP_849195.2	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	16	Helix-loop-helix motif.				transcription, DNA-dependent		DNA binding|signal transducer activity			breast(4)|endometrium(2)|kidney(3)|large_intestine(11)|liver(2)|lung(20)|ovary(1)|prostate(3)|skin(3)	49						GGGACCAGATCAACGCCGAGA	0.677000													9	23					0	0	1	0	0
ANGPTL5	253935	broad.mit.edu	37	11	101762128	101762128	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr11:101762128G>C	ENST00000334289.3	-	9	1644	c.1049C>G	c.(1048-1050)tCt>tGt	p.S350C		NM_178127.4	NP_835228.2	Q86XS5	ANGL5_HUMAN	angiopoietin-like 5	350	Fibrinogen C-terminal.				signal transduction	extracellular space	receptor binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(10)|lung(10)|ovary(2)|skin(3)	29		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.043)		BRCA - Breast invasive adenocarcinoma(274;0.0328)		CAATTTTCCAGAGAAGTGATG	0.418000													32	94					0	0	1	0	0
REEP4	80346	broad.mit.edu	37	8	21997501	21997501	+	Missense_Mutation	SNP	T	T	G			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr8:21997501T>G	ENST00000306306.3	-	4	746	c.278A>C	c.(277-279)cAc>cCc	p.H93P	REEP4_ENST00000523293.1_Missense_Mutation_p.H93P|REEP4_ENST00000334530.5_Missense_Mutation_p.H93P	NM_025232.2	NP_079508.2	Q9H6H4	REEP4_HUMAN	receptor accessory protein 4	93						integral to membrane				kidney(1)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	7				Colorectal(74;0.00187)|COAD - Colon adenocarcinoma(73;0.061)|READ - Rectum adenocarcinoma(644;0.0993)		CAGGGACGGGTGGACAAACTT	0.587000													4	2					0	0	1	0	0
PHF12	57649	broad.mit.edu	37	17	27233293	27233293	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr17:27233293C>T	ENST00000332830.4	-	15	3733	c.2923G>A	c.(2923-2925)Gat>Aat	p.D975N	PHF12_ENST00000577226.1_3'UTR	NM_001033561.1	NP_001028733.1	Q96QT6	PHF12_HUMAN	PHD finger protein 12	975					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	protein binding|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	30	all_cancers(5;1.95e-14)|all_epithelial(6;5e-18)|Lung NSC(42;0.01)		Epithelial(11;1.64e-05)|all cancers(11;7.47e-05)|BRCA - Breast invasive adenocarcinoma(11;9.79e-05)			AGGCTGGCATCGCCTTTGGGC	0.597000													7	41					0	0	1	0	0
SHC4	399694	broad.mit.edu	37	15	49160017	49160017	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr15:49160017C>T	ENST00000332408.4	-	6	1372	c.944G>A	c.(943-945)cGa>cAa	p.R315Q	SHC4_ENST00000537958.1_Missense_Mutation_p.R29Q|SHC4_ENST00000396535.3_Missense_Mutation_p.R72Q	NM_203349.3	NP_976224.3	Q6S5L8	SHC4_HUMAN	SHC (Src homology 2 domain containing) family, member 4	315	PID.				intracellular signal transduction	cell junction|postsynaptic membrane				breast(1)|endometrium(2)|large_intestine(8)|lung(11)|ovary(3)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)	29		all_lung(180;0.00466)		all cancers(107;9.4e-08)|GBM - Glioblastoma multiforme(94;5.94e-07)		TTCCATACCTCGTTGATTAAC	0.333000													9	58					0	0	1	0	0
HIVEP2	3097	broad.mit.edu	37	6	143095507	143095507	+	Silent	SNP	C	C	A			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr6:143095507C>A	ENST00000367603.2	-	5	1111	c.369G>T	c.(367-369)ccG>ccT	p.P123P	HIVEP2_ENST00000012134.2_Silent_p.P123P|HIVEP2_ENST00000367604.1_Silent_p.P123P	NM_006734.3	NP_006725.3	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer binding protein 2	123					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(4)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(19)|lung(35)|ovary(4)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	100				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		GGAAAAGCCACGGAGGACCTT	0.507000													29	88					2.61193e-14	2.97683e-14	1	1	0
MT-CO3	4514	broad.mit.edu	37	MT	9535	9535	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chrM:9535C>T	ENST00000362079.2	+	1	329	c.329C>T	c.(328-330)cCc>cTc	p.110_110insL						mitochondrially encoded cytochrome c oxidase III											breast(1)|endometrium(10)|kidney(14)|lung(1)|urinary_tract(1)	27						AGCCCCTACCCCCCAACTAGG	0.493000													15	78					0	0	1	0	0
GLP2R	9340	broad.mit.edu	37	17	9774131	9774131	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr17:9774131G>T	ENST00000262441.5	+	10	1637	c.1124G>T	c.(1123-1125)tGc>tTc	p.C375F	GLP2R_ENST00000574745.1_Missense_Mutation_p.C195F	NM_004246.1	NP_004237.1	O95838	GLP2R_HUMAN	glucagon-like peptide 2 receptor	375					G-protein signaling, coupled to cAMP nucleotide second messenger|positive regulation of cell proliferation	integral to membrane|plasma membrane				endometrium(4)|large_intestine(7)|lung(22)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	44					Glucagon recombinant(DB00040)	CATCAAATGTGCTTCAGAGAT	0.413000													45	164					3.05275e-18	3.55771e-18	1	1	0
ASCC3	10973	broad.mit.edu	37	6	101073102	101073102	+	Missense_Mutation	SNP	T	T	C			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr6:101073102T>C	ENST00000369162.2	-	30	5095	c.4751A>G	c.(4750-4752)gAt>gGt	p.D1584G		NM_006828.2	NP_006819.2	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit 3	1584	Helicase C-terminal 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(20)|liver(1)|lung(36)|ovary(6)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	92		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		CTGCTTTGGATCTTCTTCAGT	0.378000													5	26					0	0	1	0	0
PRSS35	167681	broad.mit.edu	37	6	84233607	84233607	+	Silent	SNP	G	G	A			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr6:84233607G>A	ENST00000536636.1	+	3	792	c.447G>A	c.(445-447)aaG>aaA	p.K149K	PRSS35_ENST00000369700.3_Silent_p.K149K	NM_001170423.1	NP_001163894.1	Q8N3Z0	PRS35_HUMAN	protease, serine, 35	149	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			breast(2)|endometrium(2)|large_intestine(12)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	32		all_cancers(76;0.000113)|Acute lymphoblastic leukemia(125;1.09e-08)|all_hematologic(105;3.12e-05)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0768)		CAGCTGTGAAGCTTTCCACGG	0.463000													19	72					0	0	1	0	0
NLRP7	199713	broad.mit.edu	37	19	55450612	55450612	+	Silent	SNP	G	G	A			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr19:55450612G>A	ENST00000588756.1	-	6	2061	c.1575C>T	c.(1573-1575)ctC>ctT	p.L525L	NLRP7_ENST00000592784.1_Silent_p.L525L|NLRP7_ENST00000590030.1_Silent_p.L525L|NLRP7_ENST00000340844.2_Silent_p.L525L|NLRP7_ENST00000328092.5_Silent_p.L525L|NLRP7_ENST00000448121.2_Silent_p.L525L|NLRP7_ENST00000446217.1_Silent_p.L553L			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	525							ATP binding	p.L525L(1)		autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		TCTCGTTAGCGAGGCCGAATA	0.527000													13	70					0	0	1	0	0
B3GNT3	10331	broad.mit.edu	37	19	17922559	17922559	+	Nonsense_Mutation	SNP	G	G	A			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr19:17922559G>A	ENST00000318683.6	+	3	894	c.747G>A	c.(745-747)tgG>tgA	p.W249*	B3GNT3_ENST00000595387.1_Nonsense_Mutation_p.W249*	NM_014256.3	NP_055071.2	Q9Y2A9	B3GN3_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3	249					protein glycosylation	Golgi membrane|integral to plasma membrane	galactosyltransferase activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)	21						GGGCTTTTTGGAGCAAGTACT	0.592000													4	62					0	0	1	0	0
MUC2	4583	broad.mit.edu	37	11	1096359	1096359	+	Silent	SNP	C	C	A			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr11:1096359C>A	ENST00000441003.2	+	34	6411	c.6384C>A	c.(6382-6384)gtC>gtA	p.V2128V	MUC2_ENST00000361558.6_Silent_p.V266V	NM_002457.2	NP_002448.2	Q02817	MUC2_HUMAN	mucin 2, oligomeric mucus/gel-forming	4490						inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	CGCACTATGTCACCTTCGACG	0.642000													11	38					1.58986e-06	1.73541e-06	1	1	0
SHROOM3	57619	broad.mit.edu	37	4	77691933	77691933	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr4:77691933G>A	ENST00000296043.6	+	10	6457	c.5504G>A	c.(5503-5505)aGg>aAg	p.R1835K	RP11-359D14.3_ENST00000449007.1_RNA	NM_020859.3	NP_065910.3	Q8TF72	SHRM3_HUMAN	shroom family member 3	1835	ASD2.				apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(29)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	60			Lung(101;0.0903)			GACAAGTATAGGATGTTCATA	0.552000													22	81					0	0	1	0	0
EPHA8	2046	broad.mit.edu	37	1	22915727	22915727	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr1:22915727G>A	ENST00000374644.4	+	5	1415	c.1343G>A	c.(1342-1344)cGt>cAt	p.R448H	EPHA8_ENST00000538803.1_Missense_Mutation_p.R448H|EPHA8_ENST00000166244.3_Intron	NM_001006943.1	NP_001006944.1	P29322	EPHA8_HUMAN	EPH receptor A8	0	Fibronectin type-III 2.					integral to plasma membrane	ATP binding|ephrin receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(6)|lung(22)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		GTCCCGCAGCGTCCTGGTCCC	0.672000													11	41					0	0	1	0	0
PCDH10	57575	broad.mit.edu	37	4	134073649	134073649	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr4:134073649C>T	ENST00000264360.4	+	1	3180	c.2354C>T	c.(2353-2355)tCa>tTa	p.S785L		NM_032961.1	NP_116586.1	Q9P2E7	PCD10_HUMAN	protocadherin 10	785					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(30)|liver(1)|lung(72)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(2)	136				LUSC - Lung squamous cell carcinoma(193;0.227)		CTCAGCAAGTCAGACATCATG	0.627000													10	26					0	0	1	0	0
WDR44	54521	broad.mit.edu	37	X	117527030	117527030	+	Nonsense_Mutation	SNP	G	G	T			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chrX:117527030G>T	ENST00000254029.3	+	4	1017	c.622G>T	c.(622-624)Gaa>Taa	p.E208*	WDR44_ENST00000371825.3_Nonsense_Mutation_p.E208*|WDR44_ENST00000493448.1_3'UTR|WDR44_ENST00000371822.5_Nonsense_Mutation_p.E183*	NM_019045.4	NP_061918.3	Q5JSH3	WDR44_HUMAN	WD repeat domain 44	208						cytosol|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm				breast(4)|endometrium(2)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)	33						CGCTGTGGAAGAAGTGGCCCC	0.493000													4	64					0.00024832	0.000256597	1	1	0
VCAN	1462	broad.mit.edu	37	5	82835881	82835881	+	Silent	SNP	G	G	A	rs148008263		TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr5:82835881G>A	ENST00000265077.3	+	8	7624	c.7059G>A	c.(7057-7059)acG>acA	p.T2353T	VCAN_ENST00000342785.4_Intron|VCAN_ENST00000513016.1_3'UTR|VCAN-AS1_ENST00000512090.1_RNA|VCAN_ENST00000502527.2_Intron|VCAN_ENST00000343200.5_Silent_p.T1366T|VCAN_ENST00000512590.2_Intron	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	2353	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		CTTTCTCCACGGACATCGGAC	0.448000													5	41					0	0	1	0	0
MT-CO3	4514	broad.mit.edu	37	MT	9548	9548	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chrM:9548G>A	ENST00000362079.2	+	1	342	c.342G>A	c.(340-342)ggG>ggA	p.114_114insG						mitochondrially encoded cytochrome c oxidase III											breast(1)|endometrium(10)|kidney(14)|lung(1)|urinary_tract(1)	27						CAACTAGGAGGGCACTGGCCC	0.493000													7	74					0	0	1	0	0
TSPAN1	10103	broad.mit.edu	37	1	46650727	46650727	+	Silent	SNP	C	C	T			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr1:46650727C>T	ENST00000372003.1	+	7	998	c.534C>T	c.(532-534)aaC>aaT	p.N178N	TSPAN1_ENST00000498443.1_3'UTR	NM_005727.3	NP_005718.2	O60635	TSN1_HUMAN	tetraspanin 1	178						integral to membrane|lysosomal membrane				kidney(1)|large_intestine(1)|lung(5)|ovary(1)	8	Acute lymphoblastic leukemia(166;0.155)	Medulloblastoma(700;0.00498)|all_neural(321;0.0212)				GCAATGACAACGTCACCAACA	0.502000													17	82					0	0	1	0	0
PPFIA2	8499	broad.mit.edu	37	12	81778024	81778024	+	Splice_Site	SNP	C	C	A			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr12:81778024C>A	ENST00000550584.2	-	8	1058		c.e8-1		PPFIA2_ENST00000550359.2_Splice_Site|PPFIA2_ENST00000443686.3_Splice_Site|PPFIA2_ENST00000549325.1_Splice_Site|PPFIA2_ENST00000549396.1_Splice_Site|PPFIA2_ENST00000548586.1_Splice_Site|PPFIA2_ENST00000552948.1_Splice_Site|PPFIA2_ENST00000545296.2_Splice_Site|PPFIA2_ENST00000407050.4_Splice_Site|RP11-315E17.1_ENST00000546936.1_RNA|PPFIA2_ENST00000333447.7_Splice_Site	NM_001220473.1	NP_001207402.1	B7Z663	B7Z663_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2											NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(37)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)	85						TGGACAAACGCTGCAGAAATA	0.308000													4	17					0.00024832	0.000256597	1	1	0
RECQL	5965	broad.mit.edu	37	12	21624400	21624400	+	Silent	SNP	C	C	T			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr12:21624400C>T	ENST00000444129.2	-	13	2097	c.1629G>A	c.(1627-1629)gaG>gaA	p.E543E	RECQL_ENST00000421138.2_Silent_p.E543E	NM_002907.3|NM_032941.2	NP_002898.2|NP_116559.1	P46063	RECQ1_HUMAN	RecQ protein-like (DNA helicase Q1-like)	543					DNA recombination|DNA repair|DNA replication	nucleus	ATP binding|ATP-dependent 3'-5' DNA helicase activity|DNA strand annealing activity|protein binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	17						CAATAATCTTCTCCAGATCTT	0.378000								Other identified genes with known or suspected DNA repair function					13	49					0	0	1	0	0
FNIP2	57600	broad.mit.edu	37	4	159789958	159789958	+	Missense_Mutation	SNP	T	T	G			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr4:159789958T>G	ENST00000264433.6	+	13	2245	c.2170T>G	c.(2170-2172)Ttt>Gtt	p.F724V	FNIP2_ENST00000379346.3_Missense_Mutation_p.F747V	NM_020840.1	NP_065891.1	Q9P278	FNIP2_HUMAN	folliculin interacting protein 2	724	Interaction with PRKAA1.				DNA damage response, signal transduction resulting in induction of apoptosis|protein phosphorylation|regulation of protein phosphorylation	cytoplasm	protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|prostate(1)	9	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.00936)		GATTGGAAGCTTTGCATCTCC	0.542000													22	59					0	0	1	0	0
KCNE2	9992	broad.mit.edu	37	21	35742922	35742922	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr21:35742922G>A	ENST00000290310.2	+	2	285	c.145G>A	c.(145-147)Gtc>Atc	p.V49I		NM_172201.1	NP_751951.1	Q9Y6J6	KCNE2_HUMAN	potassium voltage-gated channel, Isk-related family, member 2	49					blood circulation|muscle contraction|regulation of heart contraction	lysosome|voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(1)|large_intestine(1)	2						CTTCTACTATGTCATCCTGTA	0.458000													16	70					0	0	1	0	0
MUC6	4588	broad.mit.edu	37	11	1016922	1016922	+	Missense_Mutation	SNP	C	C	G	rs71472140		TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr11:1016922C>G	ENST00000421673.2	-	31	5929	c.5879G>C	c.(5878-5880)aGc>aCc	p.S1960T		NM_005961.2	NP_005952.2	Q6W4X9	MUC6_HUMAN	mucin 6, oligomeric mucus/gel-forming	1960	Thr-rich.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(8)|kidney(10)|large_intestine(6)|lung(43)|ovary(4)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	80		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GGGTAGCCTGCTGCTGCTGGC	0.582000													6	954					0	0	1	0	0
MGRN1	23295	broad.mit.edu	37	16	4723654	4723654	+	Silent	SNP	G	G	A			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr16:4723654G>A	ENST00000399577.5	+	10	1044	c.951G>A	c.(949-951)cgG>cgA	p.R317R	MGRN1_ENST00000588015.1_3'UTR|MGRN1_ENST00000415496.1_Silent_p.R318R|MGRN1_ENST00000586183.1_Silent_p.R317R|MGRN1_ENST00000262370.7_Silent_p.R317R|MGRN1_ENST00000588994.1_Silent_p.R317R	NM_001142290.2	NP_001135762.1	O60291	MGRN1_HUMAN	mahogunin ring finger 1, E3 ubiquitin protein ligase	317					endosome to lysosome transport|negative regulation of cAMP-mediated signaling|negative regulation of G-protein coupled receptor protein signaling pathway|protein monoubiquitination	cytosol|early endosome|nucleus|plasma membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|ovary(3)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	18						CCATCTGCCGGCTGCGTGAGT	0.652000													16	44					0	0	1	0	0
PILRB	29990	broad.mit.edu	37	7	99964984	99964984	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr7:99964984C>T	ENST00000310771.4	+	18	3164	c.668C>T	c.(667-669)cCa>cTa	p.P223L	PILRB_ENST00000452089.1_Missense_Mutation_p.P223L|PILRB_ENST00000444874.1_3'UTR|PILRB_ENST00000448382.1_3'UTR|PILRB_ENST00000444073.1_Missense_Mutation_p.P223L			Q9UKJ0	PILRB_HUMAN	paired immunoglobin-like type 2 receptor beta	223					activation of transmembrane receptor protein tyrosine kinase activity	integral to plasma membrane	protein binding|receptor activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)	13	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					agcagggcgccaagcagtgac	0.542000													14	58					0	0	1	0	0
MT-CO1	4512	broad.mit.edu	37	MT	6138	6138	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chrM:6138G>A	ENST00000361624.2	+	1	235	c.235G>A	c.(235-237)Ggc>Agc	p.79_79insS						mitochondrially encoded cytochrome c oxidase I											breast(4)|endometrium(25)|kidney(19)|lung(3)|prostate(3)	54						TCGGAGGCTTTGGCAACTGAC	0.458000													40	16					0	0	1	0	0
RBPMS	11030	broad.mit.edu	37	8	30402090	30402090	+	Silent	SNP	G	G	A	rs146741990		TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr8:30402090G>A	ENST00000320203.4	+	6	1059	c.477G>A	c.(475-477)gcG>gcA	p.A159A	RBPMS_ENST00000397323.4_Silent_p.A159A|RBPMS_ENST00000520161.1_Silent_p.A55A|RBPMS_ENST00000519647.1_Silent_p.A55A|RBPMS_ENST00000517860.1_Silent_p.A159A|RBPMS_ENST00000339877.4_Silent_p.A159A|RBPMS_ENST00000287771.5_Silent_p.A159A|RBPMS_ENST00000538486.1_Intron|RBPMS_ENST00000520191.1_Silent_p.A55A	NM_006867.2	NP_006858.1	Q93062	RBPMS_HUMAN	RNA binding protein with multiple splicing	159					positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	cytoplasm|nucleus	nucleotide binding|poly(A) RNA binding|protein binding|transcription coactivator activity			autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	13				KIRC - Kidney renal clear cell carcinoma(542;0.144)|Kidney(114;0.172)		CGGAGTTAGCGCCTGCTCTAC	0.557000													19	60					0	0	1	0	0
NODAL	4838	broad.mit.edu	37	10	72195488	72195488	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr10:72195488C>T	ENST00000287139.3	-	2	444	c.445G>A	c.(445-447)Ggc>Agc	p.G149S	AC022532.1_ENST00000420338.2_Silent_p.A145A	NM_018055.4	NP_060525.3	Q96S42	NODAL_HUMAN	nodal growth differentiation factor	149					growth	extracellular space	cytokine activity|growth factor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(4)|upper_aerodigestive_tract(2)	15						ACCATGCTGCCCAAGGAAAAG	0.577000													6	47					0	0	1	0	0
UBQLNL	143630	broad.mit.edu	37	11	5537120	5537120	+	Silent	SNP	A	A	T			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr11:5537120A>T	ENST00000380184.1	-	1	815	c.552T>A	c.(550-552)ctT>ctA	p.L184L	HBG2_ENST00000380259.2_Intron	NM_145053.4	NP_659490.4	Q8IYU4	UBQLN_HUMAN	ubiquilin-like	184										endometrium(1)|kidney(3)|large_intestine(9)|lung(13)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	33		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.136)		TGTTGGACAGAAGCCGCTGGA	0.488000													45	125					0	0	1	0	0
RBL1	5933	broad.mit.edu	37	20	35696405	35696405	+	Nonsense_Mutation	SNP	G	G	A			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr20:35696405G>A	ENST00000373664.3	-	3	541	c.475C>T	c.(475-477)Cga>Tga	p.R159*	RBL1_ENST00000344359.3_Nonsense_Mutation_p.R159*	NM_002895.2	NP_002886.2	P28749	RBL1_HUMAN	retinoblastoma-like 1 (p107)	159					cell cycle|chromatin modification|interspecies interaction between organisms|regulation of cell cycle|regulation of lipid kinase activity|transcription, DNA-dependent		transcription factor binding			NS(1)|breast(1)|endometrium(7)|large_intestine(6)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	42		Myeloproliferative disorder(115;0.00878)				TTCCGGCTTCGTGGTAACTTT	0.299000													10	45					0	0	1	0	0
TAGAP	117289	broad.mit.edu	37	6	159464620	159464620	+	Splice_Site	SNP	C	C	A			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr6:159464620C>A	ENST00000367066.3	-	4	480		c.e4+1		RP1-111C20.4_ENST00000606470.1_RNA|TAGAP_ENST00000338313.5_Splice_Site|TAGAP_ENST00000326965.6_Splice_Site	NM_054114.3	NP_473455.2	Q8N103	TAGAP_HUMAN	T-cell activation RhoGTPase activating protein						regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|guanyl-nucleotide exchange factor activity			NS(1)|autonomic_ganglia(1)|endometrium(3)|large_intestine(8)|lung(7)|ovary(2)|skin(1)	23		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-16)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		TTAAAACTCACCAATGAGCTG	0.363000													41	125					9.58827e-17	1.10909e-16	1	1	0
CSPG4	1464	broad.mit.edu	37	15	75968110	75968110	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr15:75968110G>C	ENST00000308508.5	-	10	6842	c.6750C>G	c.(6748-6750)aaC>aaG	p.N2250K		NM_001897.4	NP_001888.2	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4	2250					angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			breast(1)|cervix(2)|endometrium(5)|kidney(5)|large_intestine(3)|liver(2)|lung(18)|ovary(2)|pancreas(2)|prostate(4)|skin(4)	48						TGCCCGTCTTGTTGCGTTTTC	0.607000													22	82					0	0	1	0	0
LOC220729	220729	broad.mit.edu	37	3	197348668	197348668	+	RNA	SNP	C	C	G	rs79940815	by1000genomes	TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr3:197348668C>G	ENST00000418868.1	-	0	591					NR_003266.2																						ACTTGAGGCTCTGTCCACCAA	0.488000													5	86					0	0	1	0	0
SCNN1A	6337	broad.mit.edu	37	12	6483990	6483990	+	Missense_Mutation	SNP	T	T	C			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr12:6483990T>C	ENST00000360168.3	-	1	400	c.137A>G	c.(136-138)gAg>gGg	p.E46G	SCNN1A_ENST00000538979.1_Intron|SCNN1A_ENST00000358945.3_5'UTR|SCNN1A_ENST00000228916.2_5'UTR|SCNN1A_ENST00000543768.1_Missense_Mutation_p.E10G	NM_001159576.1	NP_001153048.1	P37088	SCNNA_HUMAN	sodium channel, non-voltage-gated 1 alpha subunit	0					excretion|response to stimulus|sensory perception of taste	apical plasma membrane	WW domain binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|liver(2)|lung(6)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	27					Amiloride(DB00594)|Triamterene(DB00384)	GTCCTGCTCCTCCAGCTTGTT	0.627000													14	44					0	0	1	0	0
PLEC	5339	broad.mit.edu	37	8	144991311	144991311	+	Silent	SNP	C	C	T			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr8:144991311C>T	ENST00000322810.4	-	32	13258	c.13089G>A	c.(13087-13089)acG>acA	p.T4363T	PLEC_ENST00000527096.1_Silent_p.T4249T|PLEC_ENST00000356346.3_Silent_p.T4212T|PLEC_ENST00000398774.2_Silent_p.T4194T|PLEC_ENST00000354958.2_Silent_p.T4204T|PLEC_ENST00000436759.2_Silent_p.T4253T|PLEC_ENST00000357649.2_Silent_p.T4230T|PLEC_ENST00000345136.3_Silent_p.T4226T|PLEC_ENST00000354589.3_Silent_p.T4226T	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	4363	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						TGATGGAGAGCGTGCCGGCGC	0.652000													5	102					0	0	1	0	0
PSMD5	5711	broad.mit.edu	37	9	123595678	123595678	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr9:123595678G>A	ENST00000210313.3	-	2	304	c.230C>T	c.(229-231)cCg>cTg	p.P77L	PSMD5_ENST00000373904.5_Missense_Mutation_p.P77L|PSMD5-AS1_ENST00000589026.1_RNA	NM_001270427.1|NM_005047.3	NP_001257356.1|NP_005038.1	Q16401	PSMD5_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 5	77					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|proteasome regulatory particle assembly|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	protein binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(2)|prostate(1)	10						CACGTGAACCGGTTCCATAGC	0.453000													25	64					0	0	1	0	0
ADAMTS16	170690	broad.mit.edu	37	5	5239807	5239807	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr5:5239807G>A	ENST00000274181.7	+	16	2430	c.2292G>A	c.(2290-2292)atG>atA	p.M764I		NM_139056.2	NP_620687.2	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 16	764	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(72)|ovary(4)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	107						ATTATCACATGGTCACCATTC	0.458000													34	130					0	0	1	0	0
METTL16	79066	broad.mit.edu	37	17	2323740	2323740	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr17:2323740C>T	ENST00000263092.5	-	10	1340	c.1213G>A	c.(1213-1215)Gcc>Acc	p.A405T	METTL16_ENST00000571669.1_5'UTR|METTL16_ENST00000538844.1_Missense_Mutation_p.A187T	NM_024086.3	NP_076991.3	Q86W50	MET16_HUMAN	methyltransferase like 16	405							methyltransferase activity			kidney(2)|large_intestine(9)|lung(4)|ovary(2)|skin(1)|urinary_tract(1)	19						TCTTCCAAGGCCTGAATGACG	0.557000													21	120					0	0	1	0	0
AP2A1	160	broad.mit.edu	37	19	50309133	50309133	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr19:50309133C>G	ENST00000354293.5	+	21	2756	c.2590C>G	c.(2590-2592)Caa>Gaa	p.Q864E	AP2A1_ENST00000359032.5_Missense_Mutation_p.Q886E	NM_130787.2	NP_570603.2	O95782	AP2A1_HUMAN	adaptor-related protein complex 2, alpha 1 subunit	886					axon guidance|endocytosis|epidermal growth factor receptor signaling pathway|Golgi to endosome transport|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|viral reproduction	AP-2 adaptor complex|clathrin coat of trans-Golgi network vesicle|cytosol	protein binding|protein transporter activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)	19		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.0023)|GBM - Glioblastoma multiforme(134;0.0157)		CCCCAGCCCTCAACAGGAGGC	0.652000													16	80					0	0	1	0	0
MDN1	23195	broad.mit.edu	37	6	90494817	90494817	+	Nonsense_Mutation	SNP	G	G	A			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr6:90494817G>A	ENST00000369393.3	-	9	1478	c.1363C>T	c.(1363-1365)Cga>Tga	p.R455*	MDN1_ENST00000428876.1_Nonsense_Mutation_p.R455*			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	455					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		TTTAGCGGTCGATACCAATTT	0.388000													4	130					0	0	1	0	0
CEACAM5	1048	broad.mit.edu	37	19	42218891	42218891	+	Splice_Site	SNP	G	G	T			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr19:42218891G>T	ENST00000221992.6	+	3	540	c.424_splice	c.e3-1	p.P142_splice	CEA_ENST00000598976.1_Intron|CEACAM5_ENST00000398599.4_Splice_Site_p.P142_splice|CEACAM5_ENST00000405816.1_Splice_Site_p.P142_splice	NM_004363.2	NP_004354.2	P06731	CEAM5_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 5	142	Ig-like 1.					anchored to membrane|basolateral plasma membrane|integral to plasma membrane				breast(1)|endometrium(3)|kidney(5)|large_intestine(4)|lung(10)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	34				OV - Ovarian serous cystadenocarcinoma(3;0.00278)|all cancers(3;0.00625)|Epithelial(262;0.0379)|GBM - Glioblastoma multiforme(1328;0.142)		TCTGCACAGCGGAGCTGCCCA	0.552000													12	175					6.40141e-05	6.89041e-05	1	1	0
VPS45	11311	broad.mit.edu	37	1	150049207	150049207	+	Silent	SNP	A	A	T			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr1:150049207A>T	ENST00000369130.3	+	6	1020	c.474A>T	c.(472-474)acA>acT	p.T158T	VPS45_ENST00000369128.5_Intron|VPS45_ENST00000535106.1_Intron	NM_007259.3	NP_009190.2	Q9NRW7	VPS45_HUMAN	vacuolar protein sorting 45 homolog (S. cerevisiae)	158					blood coagulation|intracellular protein transport|vesicle docking involved in exocytosis	endosome membrane|Golgi membrane|integral to membrane of membrane fraction				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	21	Breast(34;0.00211)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			TATCTAGAACAACTCAAGGGC	0.383000													12	58					0	0	1	0	0
LRRTM3	347731	broad.mit.edu	37	10	68686951	68686951	+	Missense_Mutation	SNP	G	G	C			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr10:68686951G>C	ENST00000361320.4	+	2	855	c.277G>C	c.(277-279)Gac>Cac	p.D93H	CTNNA3_ENST00000373744.4_Intron|CTNNA3_ENST00000494580.1_Intron|CTNNA3_ENST00000433211.1_Intron	NM_178011.3	NP_821079.3	Q86VH5	LRRT3_HUMAN	leucine rich repeat transmembrane neuronal 3	93						integral to membrane		p.D93H(2)		breast(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(20)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	41						GCTATACCTTGACCATAACCA	0.373000													28	97					0	0	1	0	0
COL14A1	7373	broad.mit.edu	37	8	121228647	121228647	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr8:121228647G>A	ENST00000297848.3	+	14	1925	c.1655G>A	c.(1654-1656)cGa>cAa	p.R552Q	COL14A1_ENST00000247781.3_Missense_Mutation_p.R457Q|COL14A1_ENST00000432943.2_3'UTR|COL14A1_ENST00000537875.1_3'UTR|COL14A1_ENST00000309791.4_Missense_Mutation_p.R552Q	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	552	Fibronectin type-III 4.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			AACAGTGCTCGATTAACCTGG	0.378000													9	98					0	0	1	0	0
KCNC1	3746	broad.mit.edu	37	11	17793572	17793572	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr11:17793572C>T	ENST00000379472.3	+	2	961	c.931C>T	c.(931-933)Cgc>Tgc	p.R311C	KCNC1_ENST00000265969.6_Missense_Mutation_p.R311C	NM_004976.4	NP_004967.1	P48547	KCNC1_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 1	311						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(9)|lung(7)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	33						GGGCTTCCTGCGCGTCGTCCG	0.632000													18	44					0	0	1	0	0
ACTL8	81569	broad.mit.edu	37	1	18152993	18152993	+	Nonsense_Mutation	SNP	T	T	A			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr1:18152993T>A	ENST00000375406.1	+	3	1296	c.1080T>A	c.(1078-1080)taT>taA	p.Y360*		NM_030812.2	NP_110439.2	Q9H568	ACTL8_HUMAN	actin-like 8	360						cytoplasm|cytoskeleton				NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(1)|lung(10)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	28		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00186)|all_lung(284;0.0054)|Lung NSC(340;0.00566)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;6.43e-06)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.00652)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)		GAGAGGAGTATGGTGAGCATA	0.517000											OREG0013157	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	35					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54860076	54860076	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr15:54860076G>T	ENST00000545554.1	+	29	6037	c.6037G>T	c.(6037-6039)Gct>Tct	p.A2013S	UNC13C_ENST00000260323.11_Missense_Mutation_p.A2013S|UNC13C_ENST00000537900.1_Missense_Mutation_p.A2011S			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	2013	MHD2.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		TCTGAGATATGCTCTCAGTCT	0.368000													6	10					8.12818e-05	8.62924e-05	1	1	0
NEK5	341676	broad.mit.edu	37	13	52684488	52684488	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr13:52684488C>G	ENST00000355568.4	-	7	594	c.455G>C	c.(454-456)aGa>aCa	p.R152T		NM_199289.1	NP_954983.1	Q6P3R8	NEK5_HUMAN	NIMA-related kinase 5	152	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(8)|lung(11)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	39		Breast(56;0.00173)|Lung NSC(96;0.0168)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;3.7e-08)		ATTCAGGACTCTTGCTATACC	0.308000													6	46					0	0	1	0	0
ZNF639	51193	broad.mit.edu	37	3	179052196	179052196	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr3:179052196C>T	ENST00000326361.3	+	7	1889	c.1444C>T	c.(1444-1446)Cat>Tat	p.H482Y	ZNF639_ENST00000484866.1_Missense_Mutation_p.H482Y|ZNF639_ENST00000496856.1_Missense_Mutation_p.H482Y	NM_016331.1	NP_057415.1	Q9UID6	ZN639_HUMAN	zinc finger protein 639	482					initiation of viral infection|negative regulation by host of viral transcription|negative regulation of transcription, DNA-dependent|positive regulation by host of viral transcription|positive regulation of cell growth|positive regulation of transcription, DNA-dependent	nucleus	protein self-association|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(1)|large_intestine(2)|lung(10)|urinary_tract(1)	16	all_cancers(143;7.9e-17)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0923)			CCTTCCAGTCCATGAGACAAC	0.323000													10	55					0	0	1	0	0
ACAA2	10449	broad.mit.edu	37	18	47323932	47323932	+	Missense_Mutation	SNP	A	A	T			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr18:47323932A>T	ENST00000285093.10	-	3	691	c.216T>A	c.(214-216)caT>caA	p.H72Q	RP11-886H22.1_ENST00000590532.2_3'UTR|ACAA2_ENST00000589432.1_Missense_Mutation_p.H17Q|ACAA2_ENST00000587994.1_Missense_Mutation_p.H69Q	NM_006111.2	NP_006102.2	P42765	THIM_HUMAN	acetyl-CoA acyltransferase 2	72					anti-apoptosis|cholesterol biosynthetic process		acetyl-CoA C-acyltransferase activity|protein binding			large_intestine(2)|lung(7)|ovary(1)	10						GCAAACCAACATGCCTTGCCA	0.388000													15	42					0	0	1	0	0
UACA	55075	broad.mit.edu	37	15	70959891	70959891	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr15:70959891C>G	ENST00000322954.6	-	16	3317	c.3132G>C	c.(3130-3132)ttG>ttC	p.L1044F	UACA_ENST00000560441.1_Missense_Mutation_p.L1029F|UACA_ENST00000539319.1_Missense_Mutation_p.L935F|UACA_ENST00000379983.2_Missense_Mutation_p.L1031F	NM_018003.2	NP_060473.2	Q9BZF9	UACA_HUMAN	uveal autoantigen with coiled-coil domains and ankyrin repeats	1044						cytoskeleton|extracellular region				breast(2)|endometrium(7)|kidney(4)|large_intestine(13)|lung(17)|ovary(2)|pancreas(1)|prostate(2)|skin(2)	50						TCTTATCTCTCAAATCTTTCT	0.353000													29	70					0	0	1	0	0
KIAA1257	57501	broad.mit.edu	37	3	128707593	128707593	+	Missense_Mutation	SNP	A	A	G			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr3:128707593A>G	ENST00000265068.5	-	3	598	c.431T>C	c.(430-432)gTa>gCa	p.V144A	KIAA1257_ENST00000510149.1_5'UTR|KIAA1257_ENST00000515659.1_Missense_Mutation_p.V32A|KIAA1257_ENST00000511438.1_Missense_Mutation_p.V144A	NM_020741.2	NP_065792.1	Q9ULG3	K1257_HUMAN	KIAA1257	144										breast(1)|endometrium(2)|large_intestine(3)|lung(6)|skin(2)	14						CTCCAGGAATACTTTGGCCAC	0.443000													7	44					0	0	1	0	0
PCDHB13	56123	broad.mit.edu	37	5	140595705	140595705	+	Silent	SNP	C	C	T			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr5:140595705C>T	ENST00000341948.4	+	1	2197	c.2010C>T	c.(2008-2010)taC>taT	p.Y670Y		NM_018933.2	NP_061756.1	Q9Y5F0	PCDBD_HUMAN		670	Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(4)|lung(24)|ovary(5)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	66			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCCAGCCCTACCTGCCTCTCC	0.677000													40	68					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216260136	216260136	+	Missense_Mutation	SNP	T	T	C			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr1:216260136T>C	ENST00000366943.2	-	24	5298	c.4912A>G	c.(4912-4914)Act>Gct	p.T1638A	RP11-22M7.2_ENST00000442606.1_RNA|RP11-22M7.2_ENST00000430890.1_RNA|RP11-22M7.2_ENST00000445619.1_RNA|USH2A_ENST00000307340.3_Missense_Mutation_p.T1638A|RP11-22M7.2_ENST00000446411.1_RNA			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	1638	Laminin G-like 1.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CCAATAACAGTACTACCATTC	0.418000										HNSCC(13;0.011)			22	43					0	0	1	0	0
NRAP	4892	broad.mit.edu	37	10	115365936	115365936	+	Splice_Site	SNP	C	C	T			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr10:115365936C>T	ENST00000369358.4	-	33	4076		c.e33+1		NRAP_ENST00000360478.3_Splice_Site|NRAP_ENST00000359988.3_Splice_Site|NRAP_ENST00000369360.3_Splice_Site			Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein							fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(18)|lung(39)|ovary(6)|prostate(3)|skin(1)|stomach(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		AAAGGGCTTACGTCACTCAGG	0.473000													5	64					0	0	1	0	0
UBR4	23352	broad.mit.edu	37	1	19421412	19421412	+	Silent	SNP	C	C	T			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr1:19421412C>T	ENST00000375267.2	-	94	13737	c.13734G>A	c.(13732-13734)ctG>ctA	p.L4578L	UBR4_ENST00000375226.2_Silent_p.L4554L|UBR4_ENST00000375254.3_Silent_p.L4578L|UBR4_ENST00000375217.2_Silent_p.L4571L|UBR4_ENST00000543981.1_Silent_p.L242L|UBR4_ENST00000467272.2_5'UTR|UBR4_ENST00000429347.2_Intron|UBR4_ENST00000375224.1_Silent_p.L285L			Q5T4S7	UBR4_HUMAN	ubiquitin protein ligase E3 component n-recognin 4	4578					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		TGTCCTCACTCAGGGGCTCAG	0.557000													4	62					0	0	1	0	0
FAM167A	83648	broad.mit.edu	37	8	11301803	11301803	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr8:11301803C>G	ENST00000284486.4	-	2	656	c.118G>C	c.(118-120)Gag>Cag	p.E40Q	FAM167A_ENST00000528897.1_Missense_Mutation_p.E40Q|FAM167A_ENST00000534308.1_Missense_Mutation_p.E40Q	NM_053279.2	NP_444509.2	Q96KS9	F167A_HUMAN	family with sequence similarity 167, member A	40										breast(1)|endometrium(1)|large_intestine(4)|lung(2)|prostate(1)	9						CTGCGGGTCTCCAGCCTCAGT	0.677000													21	59					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124268630	124268630	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr12:124268630C>A	ENST00000409039.3	+	8	978	c.953C>A	c.(952-954)gCt>gAt	p.A318D		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	318	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		ATGCTTGTGGCTAATCTGCAG	0.468000													15	66					0.000219431	0.00022981	1	1	0
PTPN6	5777	broad.mit.edu	37	12	7064379	7064379	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr12:7064379C>G	ENST00000456013.1	+	5	824	c.582C>G	c.(580-582)ttC>ttG	p.F194L	PTPN6_ENST00000399448.1_Missense_Mutation_p.F196L|PTPN6_ENST00000447931.2_Missense_Mutation_p.F155L|PTPN6_ENST00000318974.9_Missense_Mutation_p.F194L	NM_080549.3	NP_536859.1	P29350	PTN6_HUMAN	protein tyrosine phosphatase, non-receptor type 6	194	SH2 2.				apoptosis|cell junction assembly|G-protein coupled receptor protein signaling pathway|interferon-gamma-mediated signaling pathway|leukocyte migration|negative regulation of peptidyl-tyrosine phosphorylation|platelet activation|positive regulation of cell proliferation|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of G1/S transition of mitotic cell cycle|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|T cell costimulation|type I interferon-mediated signaling pathway	cytosol|membrane|nucleus	protein binding|protein tyrosine phosphatase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(5)|prostate(3)	18						TGGAGCATTTCAAGAAGACGG	0.617000													30	114					0	0	1	0	0
ABCG4	64137	broad.mit.edu	37	11	119029033	119029033	+	Silent	SNP	C	C	T			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr11:119029033C>T	ENST00000307417.3	+	10	1522	c.1158C>T	c.(1156-1158)ctC>ctT	p.L386L	ABCG4_ENST00000531739.1_Silent_p.L386L|ABCG4_ENST00000449422.2_Silent_p.L386L	NM_022169.4	NP_071452.2	Q9H172	ABCG4_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 4	386	ABC transmembrane type-2.				cholesterol efflux	integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity|protein homodimerization activity	p.L386L(1)		breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(28)|ovary(2)|prostate(1)|skin(1)	44	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		TGTCCATCCTCAGGGACACGG	0.582000													72	160					0	0	1	0	0
PDE11A	50940	broad.mit.edu	37	2	178565870	178565870	+	Silent	SNP	G	G	C	rs149627351	byFrequency	TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr2:178565870G>C	ENST00000286063.5	-	14	2540	c.2223C>G	c.(2221-2223)gcC>gcG	p.A741A	PDE11A_ENST00000409504.1_Silent_p.A383A|PDE11A_ENST00000358450.4_Silent_p.A491A|PDE11A_ENST00000389683.3_Silent_p.A297A|PDE11A_ENST00000449286.2_Silent_p.A383A|AC012499.1_ENST00000412133.1_RNA|AC012499.1_ENST00000450227.1_RNA|PDE11A_ENST00000497003.1_5'UTR	NM_016953.3	NP_058649.3	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A	741	Catalytic (By similarity).				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			GGATCATCACGGCGTGGTTGA	0.512000									Primary Pigmented Nodular Adrenocortical Disease, Familial				9	11					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144941937	144941937	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr8:144941937C>T	ENST00000525985.1	-	2	5556	c.5485G>A	c.(5485-5487)Gaa>Aaa	p.E1829K				P58107	EPIPL_HUMAN	epiplakin 1	1829						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GTGATGATTTCCAGCAATTTC	0.537000													11	228					0	0	1	0	0
GIT1	28964	broad.mit.edu	37	17	27904726	27904726	+	Silent	SNP	C	C	A			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr17:27904726C>A	ENST00000225394.3	-	10	1166	c.918G>T	c.(916-918)gtG>gtT	p.V306V	GIT1_ENST00000581348.1_Silent_p.V315V|GIT1_ENST00000394869.3_Silent_p.V315V|GIT1_ENST00000579937.1_Silent_p.V306V|RP11-68I3.2_ENST00000581474.1_RNA	NM_014030.3	NP_054749.2	Q9Y2X7	GIT1_HUMAN	G protein-coupled receptor kinase interacting ArfGAP 1	306	ARHGEF6-binding (By similarity).|PTK2-binding (By similarity).				regulation of ARF GTPase activity|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|focal adhesion	ARF GTPase activator activity|protein binding|zinc ion binding			large_intestine(2)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	9				READ - Rectum adenocarcinoma(3;0.0419)|Colorectal(3;0.069)		TGCGCTCTGTCACCAGAGTGC	0.642000													26	91					1.30897e-18	1.53705e-18	1	1	0
MUC6	4588	broad.mit.edu	37	11	1017429	1017429	+	Missense_Mutation	SNP	C	C	G			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr11:1017429C>G	ENST00000421673.2	-	31	5422	c.5372G>C	c.(5371-5373)aGc>aCc	p.S1791T		NM_005961.2	NP_005952.2	Q6W4X9	MUC6_HUMAN	mucin 6, oligomeric mucus/gel-forming	1791	Approximate repeats.|Thr-rich.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(8)|kidney(10)|large_intestine(6)|lung(43)|ovary(4)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	80		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GGGTAGCCTGCTGCTGGTGGC	0.592000													7	952					0	0	1	0	0
LOC100294341	100294341	broad.mit.edu	37	17	43587569	43587569	+	RNA	SNP	G	G	C	rs149697015	by1000genomes	TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr17:43587569G>C	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							aactccgtctgaaaagaaaag	0.443000													3	38					0	0	1	0	0
LINC00971	440970	broad.mit.edu	37	3	84740860	84740861	+	RNA	INS	-	-	AT			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr3:84740860_84740861insAT	ENST00000484892.1	-	0	2354					NR_033860.1																						GGTGACCTACAATAGGCAGCAC	0.446													8	22	---	---	---	---					
RRP36	88745	broad.mit.edu	37	6	42989414	42989419	+	In_Frame_Del	DEL	GCCGGG	GCCGGG	-	rs60664426		TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr6:42989414_42989419delGCCGGG	ENST00000244496.5	+	1	32_37	c.22_27delGCCGGG	c.(22-27)del	p.AG14del		NM_033112.2	NP_149103.1	Q96EU6	RRP36_HUMAN	ribosomal RNA processing 36 homolog (S. cerevisiae)	14					ribosomal small subunit biogenesis|rRNA processing	nucleolus		p.A8_G9delAG(2)		NS(1)|breast(1)|central_nervous_system(1)|large_intestine(5)|lung(1)|ovary(1)|prostate(1)	11						TAACTAccgcgccggggccggggccg	0.777													3	6	---	---	---	---					
CUX1	1523	broad.mit.edu	37	7	101892133	101892135	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr7:101892133_101892135delCAG	ENST00000360264.3	+	24	4382_4384	c.4362_4364delCAG	c.(4360-4365)aac>aa	p.NS1454del	CUX1_ENST00000393824.3_Intron|CUX1_ENST00000292538.4_Intron|CUX1_ENST00000560541.1_Intron|CUX1_ENST00000292535.7_In_Frame_Del_p.NS1443del|CUX1_ENST00000556210.1_In_Frame_Del_p.NS1285del|CUX1_ENST00000550008.2_In_Frame_Del_p.NS1387del|CUX1_ENST00000549414.2_In_Frame_Del_p.NS1421del|CUX1_ENST00000437600.4_Intron|CUX1_ENST00000547394.2_Intron|CUX1_ENST00000425244.2_Intron|CUX1_ENST00000546411.2_In_Frame_Del_p.NS1341del	NM_001202543.1	NP_001189472.1	P39880	CUX1_HUMAN	cut-like homeobox 1	1443					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(8)|lung(26)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|stomach(1)|urinary_tract(5)	70						CGCCCAGCAACAGCAGCAGCAGC	0.823													2	4	---	---	---	---					
SMARCA2	6595	broad.mit.edu	37	9	2123926	2123926	+	Frame_Shift_Del	DEL	C	C	-			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr9:2123926delC	ENST00000382203.1	+	27	4179	c.3970delC	c.(3970-3972)agfs	p.Q1324fs	SMARCA2_ENST00000349721.2_Frame_Shift_Del_p.Q1324fs|SMARCA2_ENST00000382194.1_Frame_Shift_Del_p.Q1324fs|SMARCA2_ENST00000357248.2_Frame_Shift_Del_p.Q1324fs			P51531	SMCA2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	1324					chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		CACGGAGAAGCAGTGGCTAAG	0.547													2	4	---	---	---	---					
LINC01410	103352539	broad.mit.edu	37	9	66464331	66464332	+	RNA	INS	-	-	A	rs142894132		TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr9:66464331_66464332insA	ENST00000424345.1	+	0	224																											GCACAATAGACAAAATATTCTC	0.332													5	2	---	---	---	---					
KMT2D	8085	broad.mit.edu	37	12	49420547	49420565	+	Frame_Shift_Del	DEL	CCGTGGACCAAAGGGCACA	CCGTGGACCAAAGGGCACA	-			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr12:49420547_49420565delCCGTGGACCAAAGGGCACA	ENST00000301067.7	-	48	15183_15201	c.15184_15202delTGTGCCCTTTGGTCCACGG	c.(15184-15204)agfs	p.CALWSTE5062fs		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		TCATACACCTCCGTGGACCAAAGGGCACAGTTGAGGTGC	0.621													9	49	---	---	---	---					
UBE2Q2P2	100134869	broad.mit.edu	37	15	83081482	83081483	+	RNA	INS	-	-	G			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr15:83081482_83081483insG	ENST00000558477.1	+	0	510					NR_004847.2																						AAATGttttttttttttttttt	0.327													2	4	---	---	---	---					
THAP11	57215	broad.mit.edu	37	16	67876538	67876538	+	Frame_Shift_Del	DEL	A	A	-			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr16:67876538delA	ENST00000303596.1	+	1	326	c.81delA	c.(79-81)ccfs	p.P27fs	CENPT_ENST00000562787.1_Intron	NM_020457.2	NP_065190.2	Q96EK4	THA11_HUMAN	THAP domain containing 11	27					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|identical protein binding|metal ion binding			cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|urinary_tract(1)	8		Acute lymphoblastic leukemia(13;0.000299)|all_hematologic(13;0.0184)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00412)|Epithelial(162;0.018)|all cancers(182;0.118)		ACACGTTTCCAAAGGACGCTG	0.652													2	4	---	---	---	---					
GHDC	84514	broad.mit.edu	37	17	40345560	40345562	+	In_Frame_Del	DEL	GCA	GCA	-			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr17:40345560_40345562delGCA	ENST00000301671.8	-	2	479_481	c.38_40delTGC	c.(37-42)cca>c	p.LP13del	GHDC_ENST00000436923.2_In_Frame_Del_p.LP13del|GHDC_ENST00000428494.2_In_Frame_Del_p.LP13del|GHDC_ENST00000587427.1_In_Frame_Del_p.LP13del|GHDC_ENST00000414034.3_In_Frame_Del_p.LP13del|GHDC_ENST00000590520.1_5'UTR|GHDC_ENST00000593209.1_In_Frame_Del_p.LP13del			Q8N2G8	GHDC_HUMAN	GH3 domain containing	13						endoplasmic reticulum|nuclear envelope				central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13		all_cancers(22;0.000229)|Breast(137;0.00104)|all_epithelial(22;0.00304)		BRCA - Breast invasive adenocarcinoma(366;0.124)		GCCAATGTTGgcagcagcagcag	0.631													2	4	---	---	---	---					
NFE2L1	4779	broad.mit.edu	37	17	46136269	46136276	+	Frame_Shift_Del	DEL	GACTCTGA	GACTCTGA	-			TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr17:46136269_46136276delGACTCTGA	ENST00000362042.3	+	6	2201_2208	c.1585_1592delGACTCTGA	c.(1585-1593)gfs	p.DSE529fs	NFE2L1_ENST00000582155.1_Frame_Shift_Del_p.DSE341fs|NFE2L1_ENST00000536222.1_Frame_Shift_Del_p.DSE373fs|NFE2L1_ENST00000585291.1_Frame_Shift_Del_p.DSE499fs|NFE2L1_ENST00000583378.1_Frame_Shift_Del_p.DSE330fs|NFE2L1_ENST00000361665.3_Frame_Shift_Del_p.DSE518fs|NFE2L1_ENST00000357480.5_Frame_Shift_Del_p.DSE499fs	NM_003204.2	NP_003195.1	Q14494	NF2L1_HUMAN	nuclear factor, erythroid 2-like 1	529					anatomical structure morphogenesis|heme biosynthetic process|inflammatory response|transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			cervix(1)|endometrium(3)|kidney(9)|large_intestine(7)|lung(7)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						CTACAGCTCTGACTCTGAGACCCTGGAT	0.553													7	49	---	---	---	---					
CTD-2245F17.3	0	broad.mit.edu	37	19	53703995	53703995	+	RNA	DEL	T	T	-	rs113703393		TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr19:53703995delT	ENST00000597550.1	+	0	232																											TGTTTCCCCCttttttttttt	0.473													5	1	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11061392	11061394	+	RNA	DEL	AAG	AAG	-	rs60312601	by1000genomes	TCGA-QK-A8ZB-01A-11D-A391-08	TCGA-QK-A8ZB-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a72d565e-2838-42f8-a155-14ff51a727d7	adb6404c-5964-4af7-a7c7-3c0404e4281c	g.chr21:11061392_11061394delAAG	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		AGAACACAATAAGAACAACAAAA	0.251													2	4	---	---	---	---