Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
HMCN1	83872	broad.mit.edu	37	1	186135336	186135336	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6IF-01A-11D-A31L-08	TCGA-QK-A6IF-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80841ea-55be-4fc9-9353-604846afea4b	670a32a1-f498-40b8-96cc-ad24ebe37796	g.chr1:186135336G>A	ENST00000271588.4	+	99	15569	c.15340G>A	c.(15340-15342)Ggg>Agg	p.G5114R	HMCN1_ENST00000367492.2_Missense_Mutation_p.G5114R	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	5114	EGF-like 1; calcium-binding (Potential).				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						ATGTGCAGCAGGGAATCCCTG	0.443000													9	30					0	0	1	0	0
POLD1	5424	broad.mit.edu	37	19	50905073	50905073	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6IF-01A-11D-A31L-08	TCGA-QK-A6IF-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80841ea-55be-4fc9-9353-604846afea4b	670a32a1-f498-40b8-96cc-ad24ebe37796	g.chr19:50905073C>T	ENST00000440232.2	+	4	408	c.355C>T	c.(355-357)Cgc>Tgc	p.R119C	POLD1_ENST00000599857.1_Missense_Mutation_p.R119C|POLD1_ENST00000595904.1_Missense_Mutation_p.R119C	NM_001256849.1|NM_002691.3	NP_001243778.1|NP_002682.2	P28340	DPOD1_HUMAN	polymerase (DNA directed), delta 1, catalytic subunit	119			R -> H (in dbSNP:rs1726801).		base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|DNA synthesis involved in DNA repair|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|response to UV|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	delta DNA polymerase complex|nucleoplasm|nucleotide-excision repair complex	3'-5'-exodeoxyribonuclease activity|chromatin binding|DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(6)|lung(8)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		all_neural(266;0.0571)		OV - Ovarian serous cystadenocarcinoma(262;0.00794)|GBM - Glioblastoma multiforme(134;0.0195)		CCCACCATCCCGCGGCTCCGT	0.672000								DNA polymerases (catalytic subunits)					27	61					0	0	1	0	0
NECAB1	64168	broad.mit.edu	37	8	91963412	91963412	+	Missense_Mutation	SNP	C	C	A			TCGA-QK-A6IF-01A-11D-A31L-08	TCGA-QK-A6IF-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80841ea-55be-4fc9-9353-604846afea4b	670a32a1-f498-40b8-96cc-ad24ebe37796	g.chr8:91963412C>A	ENST00000417640.2	+	12	1347	c.1010C>A	c.(1009-1011)aCa>aAa	p.T337K	NECAB1_ENST00000521366.1_Missense_Mutation_p.T86K|NECAB1_ENST00000522820.1_Missense_Mutation_p.T86K	NM_022351.4	NP_071746.1	Q8N987	NECA1_HUMAN	N-terminal EF-hand calcium binding protein 1	337					antibiotic biosynthetic process	cytoplasm	calcium ion binding|oxidoreductase activity	p.T337I(1)		breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(7)	12			BRCA - Breast invasive adenocarcinoma(11;0.0499)			CCAGAACTCACATCTACAATG	0.343000													14	28					8.60227e-14	8.79344e-14	1	1	0
PDLIM1	9124	broad.mit.edu	37	10	97028545	97028545	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6IF-01A-11D-A31L-08	TCGA-QK-A6IF-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80841ea-55be-4fc9-9353-604846afea4b	670a32a1-f498-40b8-96cc-ad24ebe37796	g.chr10:97028545G>A	ENST00000329399.6	-	3	431	c.323C>T	c.(322-324)tCt>tTt	p.S108F	PDLIM1_ENST00000477757.1_5'UTR	NM_020992.2	NP_066272.1	O00151	PDLI1_HUMAN	PDZ and LIM domain 1	108					response to oxidative stress	cytoplasm|cytoskeleton	zinc ion binding			endometrium(1)|large_intestine(5)|lung(1)|ovary(1)|skin(2)	10		Colorectal(252;0.083)		Epithelial(162;1.64e-06)|all cancers(201;3.71e-05)		CTGGGGTTCAGAGGCTAAATT	0.498000													21	66					0	0	1	0	0
ASCL1	429	broad.mit.edu	37	12	103352385	103352385	+	Silent	SNP	G	G	A			TCGA-QK-A6IF-01A-11D-A31L-08	TCGA-QK-A6IF-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80841ea-55be-4fc9-9353-604846afea4b	670a32a1-f498-40b8-96cc-ad24ebe37796	g.chr12:103352385G>A	ENST00000266744.3	+	1	922	c.363G>A	c.(361-363)gcG>gcA	p.A121A		NM_004316.3	NP_004307.2	P50553	ASCL1_HUMAN	achaete-scute family bHLH transcription factor 1	121					cerebral cortex GABAergic interneuron differentiation|negative regulation of apoptosis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|noradrenergic neuron fate commitment|Notch signaling pathway|positive regulation of neuron differentiation|positive regulation of transcription from RNA polymerase II promoter|response to retinoic acid|sympathetic nervous system development	nucleus	bHLH transcription factor binding|E-box binding|sequence-specific DNA binding transcription factor activity|transcription factor binding transcription factor activity			NS(3)|large_intestine(1)|lung(1)	5						CCGCCGTGGCGCGCCGCAACG	0.667000													4	18					0	0	1	0	0
FBXW12	285231	broad.mit.edu	37	3	48415175	48415175	+	Missense_Mutation	SNP	A	A	G			TCGA-QK-A6IF-01A-11D-A31L-08	TCGA-QK-A6IF-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80841ea-55be-4fc9-9353-604846afea4b	670a32a1-f498-40b8-96cc-ad24ebe37796	g.chr3:48415175A>G	ENST00000296438.5	+	4	452	c.266A>G	c.(265-267)tAc>tGc	p.Y89C	FBXW12_ENST00000445170.1_Missense_Mutation_p.Y70C|FBXW12_ENST00000436231.1_Intron|FBXW12_ENST00000415155.1_Missense_Mutation_p.Y89C	NM_207102.2	NP_996985.2	Q6X9E4	FBW12_HUMAN	F-box and WD repeat domain containing 12	89										breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		AACTTTATCTACAAAGTAACT	0.448000													18	36					0	0	1	0	0
EEF1A1	1915	broad.mit.edu	37	6	74228090	74228090	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6IF-01A-11D-A31L-08	TCGA-QK-A6IF-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80841ea-55be-4fc9-9353-604846afea4b	670a32a1-f498-40b8-96cc-ad24ebe37796	g.chr6:74228090C>T	ENST00000316292.9	-	5	2007	c.1016G>A	c.(1015-1017)gGc>gAc	p.G339D	EEF1A1_ENST00000331523.2_Missense_Mutation_p.G339D|EEF1A1_ENST00000309268.6_Missense_Mutation_p.G339D|EEF1A1_ENST00000491404.1_Intron	NM_001402.5	NP_001393.1	P68104	EF1A1_HUMAN	eukaryotic translation elongation factor 1 alpha 1	339						cytosol|eukaryotic translation elongation factor 1 complex	GTP binding|GTPase activity|protein binding|translation elongation factor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(6)|prostate(2)|skin(3)	18						AGCAGTGAAGCCAGCTGCTTC	0.418000											OREG0003895	type=REGULATORY REGION|Gene=D16891|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	21	53					0	0	1	0	0
KPNA6	23633	broad.mit.edu	37	1	32625009	32625009	+	Silent	SNP	T	T	G			TCGA-QK-A6IF-01A-11D-A31L-08	TCGA-QK-A6IF-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80841ea-55be-4fc9-9353-604846afea4b	670a32a1-f498-40b8-96cc-ad24ebe37796	g.chr1:32625009T>G	ENST00000373625.3	+	6	528	c.435T>G	c.(433-435)gcT>gcG	p.A145A	KPNA6_ENST00000469790.1_3'UTR|KPNA6_ENST00000545542.1_Silent_p.A150A|KPNA6_ENST00000537234.1_Silent_p.A142A	NM_012316.4	NP_036448.1	O60684	IMA7_HUMAN	karyopherin alpha 6 (importin alpha 7)	145					NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding			large_intestine(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				AGTTTGAAGCTGCCTGGGCTC	0.463000													29	51					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152282739	152282739	+	Silent	SNP	G	G	A			TCGA-QK-A6IF-01A-11D-A31L-08	TCGA-QK-A6IF-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80841ea-55be-4fc9-9353-604846afea4b	670a32a1-f498-40b8-96cc-ad24ebe37796	g.chr1:152282739G>A	ENST00000368799.1	-	3	4658	c.4623C>T	c.(4621-4623)agC>agT	p.S1541S	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1541	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTGTTTGCCTGCTTGCACTTC	0.572000									Ichthyosis				37	344					0	0	1	0	0
HK3	3101	broad.mit.edu	37	5	176309093	176309093	+	Missense_Mutation	SNP	G	G	A	rs147409752	by1000genomes	TCGA-QK-A6IF-01A-11D-A31L-08	TCGA-QK-A6IF-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80841ea-55be-4fc9-9353-604846afea4b	670a32a1-f498-40b8-96cc-ad24ebe37796	g.chr5:176309093G>A	ENST00000292432.5	-	16	2180	c.2089C>T	c.(2089-2091)Cgg>Tgg	p.R697W		NM_002115.2	NP_002106.2	P52790	HXK3_HUMAN	hexokinase 3 (white cell)	697	Catalytic.				glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(21)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	47	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCCACATTCCGGAGCTCCTCC	0.607000													23	28					0	0	1	0	0
NPAS2	4862	broad.mit.edu	37	2	101591395	101591395	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6IF-01A-11D-A31L-08	TCGA-QK-A6IF-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80841ea-55be-4fc9-9353-604846afea4b	670a32a1-f498-40b8-96cc-ad24ebe37796	g.chr2:101591395C>T	ENST00000335681.5	+	13	1556	c.1271C>T	c.(1270-1272)tCa>tTa	p.S424L	NPAS2_ENST00000542504.1_Missense_Mutation_p.S489L|AC016738.3_ENST00000446644.1_RNA|AC016738.3_ENST00000439150.1_RNA	NM_002518.3	NP_002509.2	Q99743	NPAS2_HUMAN	neuronal PAS domain protein 2	424					central nervous system development|positive regulation of transcription from RNA polymerase II promoter|rhythmic process	transcription factor complex	DNA binding|Hsp90 protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			cervix(1)|endometrium(3)|large_intestine(7)|lung(9)|ovary(3)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						ACAGCCATGTCAGAACCCACC	0.577000													26	5					0	0	1	0	0
SRSF5	6430	broad.mit.edu	37	14	70235548	70235548	+	Silent	SNP	A	A	G			TCGA-QK-A6IF-01A-11D-A31L-08	TCGA-QK-A6IF-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80841ea-55be-4fc9-9353-604846afea4b	670a32a1-f498-40b8-96cc-ad24ebe37796	g.chr14:70235548A>G	ENST00000553521.1	+	5	1684	c.231A>G	c.(229-231)cgA>cgG	p.R77R	SRSF5_ENST00000555349.1_Silent_p.R77R|SRSF5_ENST00000554021.1_Silent_p.R77R|SRSF5_ENST00000553548.1_Silent_p.R77R|SRSF5_ENST00000553635.1_Silent_p.R74R|SRSF5_ENST00000451983.2_Silent_p.R77R|SRSF5_ENST00000557154.1_Silent_p.R77R|SRSF5_ENST00000556587.1_3'UTR|SRSF5_ENST00000394366.2_Silent_p.R77R			Q13243	SRSF5_HUMAN	serine/arginine-rich splicing factor 5	77					mRNA 3'-end processing|mRNA export from nucleus|mRNA splice site selection|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|protein binding|RNA binding			large_intestine(1)|liver(1)	2						CTCGGTCACGAGGTGGAAGAG	0.423000													3	53					0	0	1	0	0
SEC24B	10427	broad.mit.edu	37	4	110451514	110451514	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6IF-01A-11D-A31L-08	TCGA-QK-A6IF-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80841ea-55be-4fc9-9353-604846afea4b	670a32a1-f498-40b8-96cc-ad24ebe37796	g.chr4:110451514C>T	ENST00000265175.5	+	19	3201	c.3146C>T	c.(3145-3147)tCa>tTa	p.S1049L	SEC24B_ENST00000504968.2_Missense_Mutation_p.S1079L|SEC24B_ENST00000399100.2_Missense_Mutation_p.S1014L	NM_006323.2	NP_006314.2	O95487	SC24B_HUMAN	SEC24 family member B	1049					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|transporter activity|zinc ion binding			breast(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(12)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.03e-05)		GTAGTGGACTCATTGTCTGCA	0.448000													15	21					0	0	1	0	0
ACTN2	88	broad.mit.edu	37	1	236882250	236882250	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6IF-01A-11D-A31L-08	TCGA-QK-A6IF-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80841ea-55be-4fc9-9353-604846afea4b	670a32a1-f498-40b8-96cc-ad24ebe37796	g.chr1:236882250G>A	ENST00000366578.4	+	3	464	c.298G>A	c.(298-300)Gtc>Atc	p.V100I	ACTN2_ENST00000542672.1_Missense_Mutation_p.V100I|ACTN2_ENST00000492634.1_3'UTR	NM_001103.2|NM_001278343.1	NP_001094.1|NP_001265272.1	P35609	ACTN2_HUMAN	actinin, alpha 2	100	Actin-binding.|CH 1.				focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			endometrium(4)|kidney(2)|large_intestine(15)|lung(55)|ovary(4)|prostate(3)|skin(3)	86	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			AATTGCTAATGTCAACAAAGC	0.502000													20	40					0	0	1	0	0
KRTAP17-1	83902	broad.mit.edu	37	17	39471807	39471807	+	Silent	SNP	G	G	A			TCGA-QK-A6IF-01A-11D-A31L-08	TCGA-QK-A6IF-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80841ea-55be-4fc9-9353-604846afea4b	670a32a1-f498-40b8-96cc-ad24ebe37796	g.chr17:39471807G>A	ENST00000334202.3	-	1	140	c.96C>T	c.(94-96)tgC>tgT	p.C32C		NM_031964.1	NP_114170.1	Q9BYP8	KR171_HUMAN	keratin associated protein 17-1	32						intermediate filament				haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)	2		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000449)			agcaggagccgcagcagccac	0.682000													8	6					0	0	1	0	0
ZFC3H1	196441	broad.mit.edu	37	12	72027093	72027093	+	Missense_Mutation	SNP	T	T	A			TCGA-QK-A6IF-01A-11D-A31L-08	TCGA-QK-A6IF-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80841ea-55be-4fc9-9353-604846afea4b	670a32a1-f498-40b8-96cc-ad24ebe37796	g.chr12:72027093T>A	ENST00000378743.3	-	13	2994	c.2636A>T	c.(2635-2637)gAa>gTa	p.E879V		NM_144982.4	NP_659419.3	O60293	ZC3H1_HUMAN	zinc finger, C3H1-type containing	879					RNA processing	intracellular	metal ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(31)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	69						AAGAATTTTTTCAGTTGCTTG	0.294000													4	8					0	0	1	0	0
ANKS6	203286	broad.mit.edu	37	9	101546340	101546340	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6IF-01A-11D-A31L-08	TCGA-QK-A6IF-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80841ea-55be-4fc9-9353-604846afea4b	670a32a1-f498-40b8-96cc-ad24ebe37796	g.chr9:101546340G>A	ENST00000353234.4	-	4	1054	c.1007C>T	c.(1006-1008)aCg>aTg	p.T336M	ANKS6_ENST00000375019.2_Missense_Mutation_p.T35M|ANKS6_ENST00000540940.1_Missense_Mutation_p.T141M|ANKS6_ENST00000375018.1_Missense_Mutation_p.T336M			Q68DC2	ANKS6_HUMAN	ankyrin repeat and sterile alpha motif domain containing 6	336										endometrium(3)|large_intestine(6)|lung(6)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	21		Acute lymphoblastic leukemia(62;0.0527)				CAGCTGCCCCGTAACAGCTGC	0.607000													22	43					0	0	1	0	0
ANKRD30BL	554226	broad.mit.edu	37	2	132905792	132905792	+	Missense_Mutation	SNP	G	G	C	rs143919579	by1000genomes	TCGA-QK-A6IF-01A-11D-A31L-08	TCGA-QK-A6IF-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80841ea-55be-4fc9-9353-604846afea4b	670a32a1-f498-40b8-96cc-ad24ebe37796	g.chr2:132905792G>C	ENST00000409867.1	-	6	938	c.689C>G	c.(688-690)tCt>tGt	p.S230C	ANKRD30BL_ENST00000470729.1_5'UTR					ankyrin repeat domain 30B-like									p.S230C(2)		endometrium(1)|kidney(3)	4						TGTTCCTTCAGATGTTCCTTC	0.443000													4	29					0	0	1	0	0
SLC9A7P1	121456	broad.mit.edu	37	12	98849305	98849305	+	RNA	SNP	C	C	G			TCGA-QK-A6IF-01A-11D-A31L-08	TCGA-QK-A6IF-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80841ea-55be-4fc9-9353-604846afea4b	670a32a1-f498-40b8-96cc-ad24ebe37796	g.chr12:98849305C>G	ENST00000554295.1	-	0	1618					NR_033801.1																						GATGCTAACTCTGATATTAAG	0.512000													3	9					0	0	1	0	0
ABO	28	broad.mit.edu	37	9	136131236	136131236	+	RNA	SNP	G	G	A			TCGA-QK-A6IF-01A-11D-A31L-08	TCGA-QK-A6IF-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80841ea-55be-4fc9-9353-604846afea4b	670a32a1-f498-40b8-96cc-ad24ebe37796	g.chr9:136131236G>A	ENST00000453660.2	-	0	892							P16442	BGAT_HUMAN	ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)						protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	fucosylgalactoside 3-alpha-galactosyltransferase activity|glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity|metal ion binding			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(2)|prostate(1)|stomach(2)	11				OV - Ovarian serous cystadenocarcinoma(145;5.82e-06)|Epithelial(140;3.45e-05)		CCTCGATGCCGTTGGCCTGGT	0.642000													15	47					0	0	1	0	0
BICD2	23299	broad.mit.edu	37	9	95491374	95491374	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6IF-01A-11D-A31L-08	TCGA-QK-A6IF-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80841ea-55be-4fc9-9353-604846afea4b	670a32a1-f498-40b8-96cc-ad24ebe37796	g.chr9:95491374G>A	ENST00000356884.6	-	2	452	c.385C>T	c.(385-387)Cgc>Tgc	p.R129C	BICD2_ENST00000375512.3_Missense_Mutation_p.R129C	NM_001003800.1	NP_001003800.1	Q8TD16	BICD2_HUMAN	bicaudal D homolog 2 (Drosophila)	129					microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule	cytoplasmic vesicle|cytoskeleton|Golgi apparatus|plasma membrane	Rab GTPase binding			cervix(3)|endometrium(4)|kidney(1)|large_intestine(6)|lung(5)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	23						AGGACATTGCGCAACTGCTTC	0.632000													4	61					0	0	1	0	0
OSBPL6	114880	broad.mit.edu	37	2	179238641	179238641	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6IF-01A-11D-A31L-08	TCGA-QK-A6IF-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80841ea-55be-4fc9-9353-604846afea4b	670a32a1-f498-40b8-96cc-ad24ebe37796	g.chr2:179238641C>T	ENST00000190611.4	+	15	1796	c.1420C>T	c.(1420-1422)Ctc>Ttc	p.L474F	OSBPL6_ENST00000315022.2_Missense_Mutation_p.L478F|OSBPL6_ENST00000409631.1_Missense_Mutation_p.L438F|OSBPL6_ENST00000409045.3_Missense_Mutation_p.L443F|OSBPL6_ENST00000392505.2_Missense_Mutation_p.L499F|OSBPL6_ENST00000359685.3_Missense_Mutation_p.L438F|OSBPL6_ENST00000357080.4_Missense_Mutation_p.L407F	NM_032523.3	NP_115912.1	Q9BZF3	OSBL6_HUMAN	oxysterol binding protein-like 6	474					lipid transport		lipid binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(13)|lung(18)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	46			OV - Ovarian serous cystadenocarcinoma(117;0.00578)|Epithelial(96;0.00847)|all cancers(119;0.0335)			CCATGTCAGTCTCCCCTTATC	0.463000													3	32					0	0	1	0	0
TPTE2P6	374491	broad.mit.edu	37	13	25161397	25161397	+	RNA	SNP	C	C	G	rs3874227	by1000genomes	TCGA-QK-A6IF-01A-11D-A31L-08	TCGA-QK-A6IF-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80841ea-55be-4fc9-9353-604846afea4b	670a32a1-f498-40b8-96cc-ad24ebe37796	g.chr13:25161397C>G	ENST00000453498.1	+	0	921																											TGAAACATCTCTACAACTGGA	0.343000													6	26					0	0	1	0	0
AJAP1	55966	broad.mit.edu	37	1	4829945	4829945	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6IF-01A-11D-A31L-08	TCGA-QK-A6IF-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80841ea-55be-4fc9-9353-604846afea4b	670a32a1-f498-40b8-96cc-ad24ebe37796	g.chr1:4829945G>A	ENST00000378191.4	+	3	1243	c.862G>A	c.(862-864)Gtc>Atc	p.V288I	AJAP1_ENST00000378190.3_Missense_Mutation_p.V288I	NM_018836.3	NP_061324.1	Q9UKB5	AJAP1_HUMAN	adherens junctions associated protein 1	288					cell adhesion	adherens junction|apical plasma membrane|basolateral plasma membrane|integral to membrane				endometrium(4)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|urinary_tract(1)	24	all_cancers(77;0.071)|Ovarian(185;0.0721)	all_cancers(23;1.77e-36)|all_epithelial(116;1.26e-21)|all_lung(118;3.51e-08)|Lung NSC(185;3.47e-06)|all_neural(13;8.84e-06)|all_hematologic(16;7.61e-05)|Breast(487;0.000507)|Renal(390;0.0007)|Colorectal(325;0.00117)|Hepatocellular(190;0.0071)|Glioma(11;0.0155)|Myeloproliferative disorder(586;0.0258)|Ovarian(437;0.0409)|Lung SC(97;0.133)|Medulloblastoma(700;0.215)		Epithelial(90;3.89e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.97e-19)|GBM - Glioblastoma multiforme(42;3.71e-19)|Colorectal(212;4.57e-06)|COAD - Colon adenocarcinoma(227;0.00019)|Kidney(185;0.000969)|BRCA - Breast invasive adenocarcinoma(365;0.00122)|STAD - Stomach adenocarcinoma(132;0.00578)|KIRC - Kidney renal clear cell carcinoma(229;0.0126)|READ - Rectum adenocarcinoma(331;0.0689)		CACCATCACCGTCTCCCTCAT	0.547000													5	154					0	0	1	0	0
ORAI3	93129	broad.mit.edu	37	16	30960832	30960832	+	Silent	SNP	C	C	T			TCGA-QK-A6IF-01A-11D-A31L-08	TCGA-QK-A6IF-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80841ea-55be-4fc9-9353-604846afea4b	670a32a1-f498-40b8-96cc-ad24ebe37796	g.chr16:30960832C>T	ENST00000318663.4	+	1	446	c.222C>T	c.(220-222)ttC>ttT	p.F74F	ORAI3_ENST00000566237.1_Silent_p.F74F|ORAI3_ENST00000562699.1_Silent_p.F74F|AC135048.13_ENST00000566056.1_RNA	NM_152288.2	NP_689501.1	Q9BRQ5	ORAI3_HUMAN	ORAI calcium release-activated calcium modulator 3	74						integral to membrane	protein binding			endometrium(1)|large_intestine(1)|lung(2)|prostate(1)|skin(1)	6						TCTCGGGCTTCGCCATGGTGA	0.692000													6	11					0	0	1	0	0
TC2N	123036	broad.mit.edu	37	14	92266688	92266688	+	Silent	SNP	G	G	A			TCGA-QK-A6IF-01A-11D-A31L-08	TCGA-QK-A6IF-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80841ea-55be-4fc9-9353-604846afea4b	670a32a1-f498-40b8-96cc-ad24ebe37796	g.chr14:92266688G>A	ENST00000435962.2	-	5	821	c.498C>T	c.(496-498)ccC>ccT	p.P166P	TC2N_ENST00000360594.5_Silent_p.P166P|TC2N_ENST00000556018.1_Silent_p.P166P|TC2N_ENST00000340892.5_Silent_p.P166P	NM_001128596.1	NP_001122068.1	Q8N9U0	TAC2N_HUMAN	tandem C2 domains, nuclear	166						nucleus				breast(1)|endometrium(2)|large_intestine(6)|liver(1)|lung(5)|skin(1)|upper_aerodigestive_tract(2)	18				COAD - Colon adenocarcinoma(157;0.218)		CAGGGGAACCGGGAAGTTTGT	0.318000													3	34					0	0	1	0	0
INO80	54617	broad.mit.edu	37	15	41372017	41372017	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6IF-01A-11D-A31L-08	TCGA-QK-A6IF-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80841ea-55be-4fc9-9353-604846afea4b	670a32a1-f498-40b8-96cc-ad24ebe37796	g.chr15:41372017C>T	ENST00000361937.3	-	9	1437	c.1013G>A	c.(1012-1014)cGc>cAc	p.R338H	INO80_ENST00000401393.3_Missense_Mutation_p.R338H			Q9ULG1	INO80_HUMAN	INO80 complex subunit	338	Assembles INO80 complex module consisting of conserved components ACTR8, ACTL6A and YY1.|DBINO.				cell division|cellular response to ionizing radiation|cellular response to UV|chromatin remodeling|double-strand break repair via homologous recombination|mitotic sister chromatid segregation|positive regulation of cell growth|positive regulation of DNA replication involved in S phase|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|spindle assembly|UV-damage excision repair	Ino80 complex|microtubule	actin binding|alpha-tubulin binding|ATP binding|ATPase activity|DNA binding|DNA helicase activity			NS(1)|breast(4)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	49						CTTGGTGAGGCGGCGGGCACG	0.527000													51	134					0	0	1	0	0
HLA-A	3105	broad.mit.edu	37	6	29911150	29911150	+	Missense_Mutation	SNP	T	T	A			TCGA-QK-A6IF-01A-11D-A31L-08	TCGA-QK-A6IF-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80841ea-55be-4fc9-9353-604846afea4b	670a32a1-f498-40b8-96cc-ad24ebe37796	g.chr6:29911150T>A	ENST00000396634.1	+	5	790	c.449T>A	c.(448-450)cTg>cAg	p.L150Q	HLA-A_ENST00000376806.5_Missense_Mutation_p.L150Q|HLA-A_ENST00000376809.5_Missense_Mutation_p.L150Q|HLA-A_ENST00000376802.2_Missense_Mutation_p.L150Q			P30443	1A01_HUMAN	major histocompatibility complex, class I, A	150	Alpha-2.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity			central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	30						TACATCGCCCTGAACGAGGAC	0.647000									Osteosarcoma, Familial Clustering of;Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of;Melanoma, Familial Clustering of;Lichen Sclerosis et Atrophicus, Familial Clustering of	Multiple Myeloma(9;0.094)			5	11					0	0	1	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-QK-A6IF-01A-11D-A31L-08	TCGA-QK-A6IF-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80841ea-55be-4fc9-9353-604846afea4b	670a32a1-f498-40b8-96cc-ad24ebe37796	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													3	38					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100678383	100678383	+	Missense_Mutation	SNP	C	C	T			TCGA-QK-A6IF-01A-11D-A31L-08	TCGA-QK-A6IF-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80841ea-55be-4fc9-9353-604846afea4b	670a32a1-f498-40b8-96cc-ad24ebe37796	g.chr7:100678383C>T	ENST00000306151.4	+	3	3750	c.3686C>T	c.(3685-3687)aCg>aTg	p.T1229M		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	1229	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					GTCAGACACACGCCAGTGGCC	0.522000													109	287					0	0	1	0	0
PTTG1IP	754	broad.mit.edu	37	21	46276126	46276126	+	Missense_Mutation	SNP	C	C	T	rs143122508		TCGA-QK-A6IF-01A-11D-A31L-08	TCGA-QK-A6IF-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80841ea-55be-4fc9-9353-604846afea4b	670a32a1-f498-40b8-96cc-ad24ebe37796	g.chr21:46276126C>T	ENST00000330938.3	-	4	651	c.431G>A	c.(430-432)cGg>cAg	p.R144Q	PTTG1IP_ENST00000494690.1_5'UTR|PTTG1IP_ENST00000445724.2_Intron|PTTG1IP_ENST00000397887.3_Intron|PTTG1IP_ENST00000397886.3_Missense_Mutation_p.R123Q	NM_004339.3	NP_004330.1	P53801	PTTG_HUMAN	pituitary tumor-transforming 1 interacting protein	144					protein import into nucleus	cytoplasm|integral to membrane|nucleus				ovary(1)|prostate(1)	2				Colorectal(79;0.0659)		CTGCCGTATCCGCCTCTCCTC	0.597000													33	80					0	0	1	0	0
RRN3P2	653390	broad.mit.edu	37	16	29110458	29110458	+	RNA	SNP	T	T	C	rs151074589	by1000genomes	TCGA-QK-A6IF-01A-11D-A31L-08	TCGA-QK-A6IF-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80841ea-55be-4fc9-9353-604846afea4b	670a32a1-f498-40b8-96cc-ad24ebe37796	g.chr16:29110458T>C	ENST00000564580.1	+	0	1131																		p.W375R(25)									GAATTTTGAGTGGATAGTGAT	0.328000													4	39					0	0	1	0	0
ZNF799	90576	broad.mit.edu	37	19	12502748	12502748	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6IF-01A-11D-A31L-08	TCGA-QK-A6IF-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80841ea-55be-4fc9-9353-604846afea4b	670a32a1-f498-40b8-96cc-ad24ebe37796	g.chr19:12502748G>A	ENST00000419318.1	-	4	1117	c.368C>T	c.(367-369)tCa>tTa	p.S123L	ZNF799_ENST00000430385.3_Missense_Mutation_p.S155L|CTD-3105H18.14_ENST00000435033.1_Intron			Q96GE5	ZN799_HUMAN	zinc finger protein 799	155					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|kidney(2)|large_intestine(4)|lung(4)|ovary(2)|prostate(2)|skin(2)	19						TGTTTGAAGTGAGTTGTGGTA	0.423000													40	64					0	0	1	0	0
ZNF788	388507	broad.mit.edu	37	19	12221164	12221164	+	Silent	SNP	C	C	T			TCGA-QK-A6IF-01A-11D-A31L-08	TCGA-QK-A6IF-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80841ea-55be-4fc9-9353-604846afea4b	670a32a1-f498-40b8-96cc-ad24ebe37796	g.chr19:12221164C>T	ENST00000430298.2	+	2	253	c.48C>T	c.(46-48)gaC>gaT	p.D16D	ZNF788_ENST00000596883.1_Silent_p.D36D|ZNF788_ENST00000339302.4_5'UTR|ZNF20_ENST00000600335.1_Intron					zinc finger family member 788											endometrium(1)|haematopoietic_and_lymphoid_tissue(1)	2						TCACCCCAGACGAGTGGGCTT	0.473000													30	47					0	0	1	0	0
CDK15	65061	broad.mit.edu	37	2	202687545	202687545	+	Silent	SNP	G	G	A			TCGA-QK-A6IF-01A-11D-A31L-08	TCGA-QK-A6IF-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80841ea-55be-4fc9-9353-604846afea4b	670a32a1-f498-40b8-96cc-ad24ebe37796	g.chr2:202687545G>A	ENST00000450471.2	+	5	548	c.462G>A	c.(460-462)aaG>aaA	p.K154K	CDK15_ENST00000260967.2_Silent_p.K103K|CDK15_ENST00000374598.4_Silent_p.K154K|CDK15_ENST00000488419.1_3'UTR|CDK15_ENST00000434439.1_Silent_p.K154K|CDK15_ENST00000410091.3_Silent_p.K103K	NM_001261435.1	NP_001248364.1	Q96Q40	CDK15_HUMAN	cyclin-dependent kinase 15	154	Protein kinase.						ATP binding|cyclin-dependent protein kinase activity|metal ion binding|protein binding			breast(3)|endometrium(2)|kidney(5)|large_intestine(1)|lung(14)|ovary(1)	26					Adenosine triphosphate(DB00171)	CTCTCCTGAAGGGTTTGAAAC	0.348000													33	28					0	0	1	0	0
ADAMTS9	56999	broad.mit.edu	37	3	64527080	64527080	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6IF-01A-11D-A31L-08	TCGA-QK-A6IF-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80841ea-55be-4fc9-9353-604846afea4b	670a32a1-f498-40b8-96cc-ad24ebe37796	g.chr3:64527080G>A	ENST00000498707.1	-	35	5645	c.5303C>T	c.(5302-5304)gCg>gTg	p.A1768V	ADAMTS9_ENST00000295903.4_Missense_Mutation_p.A1740V	NM_182920.1	NP_891550.1	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 9	1768	GON.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(17)|liver(4)|lung(43)|ovary(3)|prostate(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	100		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		GTGCATCCCCGCACAGAATAT	0.463000													4	114					0	0	1	0	0
SPDL1	54908	broad.mit.edu	37	5	169015518	169015518	+	Missense_Mutation	SNP	G	G	A			TCGA-QK-A6IF-01A-11D-A31L-08	TCGA-QK-A6IF-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80841ea-55be-4fc9-9353-604846afea4b	670a32a1-f498-40b8-96cc-ad24ebe37796	g.chr5:169015518G>A	ENST00000265295.4	+	2	377	c.98G>A	c.(97-99)aGt>aAt	p.S33N	SPDL1_ENST00000510751.1_3'UTR	NM_017785.4	NP_060255.3			spindle apparatus coiled-coil protein 1																		CTAGTAGAGAGTCAAAATGAA	0.408000													20	38					0	0	1	0	0
RALGAPA1	253959	broad.mit.edu	37	14	36190922	36190922	+	Silent	SNP	C	C	A	rs145761488	byFrequency	TCGA-QK-A6IF-01A-11D-A31L-08	TCGA-QK-A6IF-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80841ea-55be-4fc9-9353-604846afea4b	670a32a1-f498-40b8-96cc-ad24ebe37796	g.chr14:36190922C>A	ENST00000258840.6	-	16	2628	c.2238G>T	c.(2236-2238)gcG>gcT	p.A746A	RALGAPA1_ENST00000307138.6_Silent_p.A746A|RALGAPA1_ENST00000389698.3_Silent_p.A746A|RALGAPA1_ENST00000382366.3_Silent_p.A746A|RALGAPA1_ENST00000554704.1_5'UTR			Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1 (catalytic)	746					activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(7)|large_intestine(14)|lung(21)|ovary(3)|prostate(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						CTATACTCCTCGCCTTTTCGG	0.443000													4	106					0.00909568	0.00909568	1	1	0
RAB17	64284	broad.mit.edu	37	2	238483701	238483701	+	Missense_Mutation	SNP	G	G	T			TCGA-QK-A6IF-01A-11D-A31L-08	TCGA-QK-A6IF-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80841ea-55be-4fc9-9353-604846afea4b	670a32a1-f498-40b8-96cc-ad24ebe37796	g.chr2:238483701G>T	ENST00000264601.3	-	6	1229	c.600C>A	c.(598-600)aaC>aaA	p.N200K	RAB17_ENST00000409822.1_Missense_Mutation_p.N73K|RAB17_ENST00000409576.1_Intron|RAB17_ENST00000538644.1_Missense_Mutation_p.N73K	NM_022449.3	NP_071894.1	Q9H0T7	RAB17_HUMAN	RAB17, member RAS oncogene family	200					protein transport|small GTPase mediated signal transduction	intracellular|plasma membrane	GTP binding|protein binding			haematopoietic_and_lymphoid_tissue(2)|large_intestine(1)|lung(1)	4		Renal(207;0.00272)|Breast(86;0.00297)|all_hematologic(139;0.182)|Ovarian(221;0.221)		Epithelial(121;9.36e-23)|OV - Ovarian serous cystadenocarcinoma(60;1.26e-10)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000354)|Lung(119;0.011)|LUSC - Lung squamous cell carcinoma(224;0.026)		CGGGCCCCTTGTTCAGAGCCA	0.657000													22	16					1.03073e-24	1.07758e-24	1	1	0
NMU	10874	broad.mit.edu	37	4	56473603	56473603	+	Splice_Site	DEL	C	C	-			TCGA-QK-A6IF-01A-11D-A31L-08	TCGA-QK-A6IF-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80841ea-55be-4fc9-9353-604846afea4b	670a32a1-f498-40b8-96cc-ad24ebe37796	g.chr4:56473603delC	ENST00000264218.3	-	5	415		c.e5+1		NMU_ENST00000515325.1_Splice_Site|NMU_ENST00000505262.1_Intron|NMU_ENST00000511469.1_Splice_Site|NMU_ENST00000507338.1_Splice_Site	NM_006681.2	NP_006672.1	P48645	NMU_HUMAN	neuromedin U						neuropeptide signaling pathway	extracellular region				lung(3)|ovary(1)|urinary_tract(1)	5	Lung NSC(11;0.00256)|all_epithelial(27;0.075)|Glioma(25;0.08)|all_neural(26;0.101)	all_hematologic(202;0.103)	LUSC - Lung squamous cell carcinoma(4;6.72e-08)|Lung(4;6.22e-07)|Epithelial(7;0.00559)	LUSC - Lung squamous cell carcinoma(721;0.0115)		AATCATCTTACCCTTTTAGTA	0.204													2	4	---	---	---	---					
RASA4CP	401331	broad.mit.edu	37	7	44069235	44069236	+	RNA	INS	-	-	A			TCGA-QK-A6IF-01A-11D-A31L-08	TCGA-QK-A6IF-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80841ea-55be-4fc9-9353-604846afea4b	670a32a1-f498-40b8-96cc-ad24ebe37796	g.chr7:44069235_44069236insA	ENST00000446874.1	-	0	623																											CTCTCCCTGTGGGGGAGGTCAG	0.678													2	4	---	---	---	---					
CTBP2P3	220147	broad.mit.edu	37	18	58330447	58330448	+	RNA	INS	-	-	T			TCGA-QK-A6IF-01A-11D-A31L-08	TCGA-QK-A6IF-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80841ea-55be-4fc9-9353-604846afea4b	670a32a1-f498-40b8-96cc-ad24ebe37796	g.chr18:58330447_58330448insT	ENST00000591869.1	-	0	228																											CCACCATGGCCTTCTGTGATAC	0.624													2	4	---	---	---	---					
IRS4	8471	broad.mit.edu	37	X	107979125	107979126	+	Frame_Shift_Ins	INS	-	-	A			TCGA-QK-A6IF-01A-11D-A31L-08	TCGA-QK-A6IF-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80841ea-55be-4fc9-9353-604846afea4b	670a32a1-f498-40b8-96cc-ad24ebe37796	g.chrX:107979125_107979126insA	ENST00000372129.2	-	1	525_526	c.449_450insT	c.(448-450)ctafs	p.L150fs		NM_003604.2	NP_003595.1	O14654	IRS4_HUMAN	insulin receptor substrate 4	150	PH.					plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			NS(1)|breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(1)	78						AGCACTGGTATAGGGTGATCAC	0.644													26	22	---	---	---	---