Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
HTR1B	3351	broad.mit.edu	37	6	78172306	78172306	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr6:78172306G>A	ENST00000369947.2	-	1	1184	c.815C>T	c.(814-816)tCg>tTg	p.S272L		NM_000863.1	NP_000854.1	P28222	5HT1B_HUMAN	5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled	272					G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cAMP biosynthetic process|synaptic transmission	integral to plasma membrane	protein binding|serotonin receptor activity	p.S272*(1)		NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(9)|prostate(2)|upper_aerodigestive_tract(2)	25		all_cancers(76;0.0867)|Acute lymphoblastic leukemia(125;0.00119)|all_hematologic(105;0.0332)		BRCA - Breast invasive adenocarcinoma(397;0.205)	Almotriptan(DB00918)|Dexfenfluramine(DB01191)|Dihydroergotamine(DB00320)|Eletriptan(DB00216)|Ergotamine(DB00696)|Frovatriptan(DB00998)|Naratriptan(DB00952)|Pindolol(DB00960)|Propranolol(DB00571)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Venlafaxine(DB00285)|Zolmitriptan(DB00315)	GGGAACCCGCGAGTTAATAGA	0.572000													49	142					0	0	1	0	0
ICAM5	7087	broad.mit.edu	37	19	10404587	10404587	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr19:10404587C>T	ENST00000221980.4	+	7	1742	c.1679C>T	c.(1678-1680)tCt>tTt	p.S560F		NM_003259.3	NP_003250.3	Q9UMF0	ICAM5_HUMAN	intercellular adhesion molecule 5, telencephalin	560	Ig-like C2-type 6.				cell-cell adhesion	integral to plasma membrane				breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)	21			OV - Ovarian serous cystadenocarcinoma(20;2.64e-09)|Epithelial(33;4.31e-06)|all cancers(31;9.75e-06)			CCTCGGGGCTCTGCGGCCAAA	0.667000													6	75					0	0	1	0	0
PHACTR3	116154	broad.mit.edu	37	20	58330363	58330363	+	Missense_Mutation	SNP	C	C	T	rs145693547		TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr20:58330363C>T	ENST00000371015.1	+	4	952	c.485C>T	c.(484-486)aCg>aTg	p.T162M	PHACTR3_ENST00000395639.4_Missense_Mutation_p.T121M|PHACTR3_ENST00000359926.3_Missense_Mutation_p.T159M|PHACTR3_ENST00000355648.4_Missense_Mutation_p.T121M|PHACTR3_ENST00000395636.2_Missense_Mutation_p.T121M|PHACTR3_ENST00000541461.1_Missense_Mutation_p.T121M|PHACTR3_ENST00000361300.4_Missense_Mutation_p.T121M	NM_080672.3	NP_542403.1	Q96KR7	PHAR3_HUMAN	phosphatase and actin regulator 3	162						nuclear matrix	actin binding|protein phosphatase inhibitor activity	p.T162M(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|liver(2)|lung(32)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	59	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;2.76e-09)			GCCACTGGGACGGACCAGGTC	0.607000													7	25					0	0	1	0	0
GRK5	2869	broad.mit.edu	37	10	121196222	121196222	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr10:121196222G>A	ENST00000392870.2	+	9	1127	c.798G>A	c.(796-798)atG>atA	p.M266I	GRK5_ENST00000369108.3_Missense_Mutation_p.M161I	NM_005308.2	NP_005299.1	P34947	GRK5_HUMAN	G protein-coupled receptor kinase 5	266	Protein kinase.				G-protein signaling, coupled to cAMP nucleotide second messenger|regulation of G-protein coupled receptor protein signaling pathway|tachykinin receptor signaling pathway	cytoplasm|plasma membrane|soluble fraction	ATP binding|G-protein coupled receptor kinase activity|phospholipid binding|protein kinase C binding|signal transducer activity			endometrium(2)|large_intestine(5)|lung(15)|skin(3)|stomach(1)|urinary_tract(1)	27		Lung NSC(174;0.0971)|all_lung(145;0.127)|Ovarian(717;0.249)		all cancers(201;0.0227)		TGACCATCATGAATGGGGGTG	0.552000													7	42					0	0	1	0	0
OSBPL10	114884	broad.mit.edu	37	3	31789571	31789571	+	Silent	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr3:31789571G>A	ENST00000396556.2	-	5	893	c.771C>T	c.(769-771)caC>caT	p.H257H	OSBPL10_ENST00000438237.2_Silent_p.H193H|OSBPL10_ENST00000467647.1_5'UTR	NM_017784.4	NP_060254.2	Q9BXB5	OSB10_HUMAN	oxysterol binding protein-like 10	257					lipid transport		lipid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(15)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	34				STAD - Stomach adenocarcinoma(1;0.00406)		ACTCAATGGCGTGCACAAGGT	0.592000													6	37					0	0	1	0	0
SLC4A8	9498	broad.mit.edu	37	12	51888824	51888824	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr12:51888824C>G	ENST00000453097.2	+	21	3082	c.2865C>G	c.(2863-2865)ttC>ttG	p.F955L	SLC4A8_ENST00000358657.3_Missense_Mutation_p.F982L	NM_001039960.2|NM_001258401.2	NP_001035049.1|NP_001245330.1	Q2Y0W8	S4A8_HUMAN	solute carrier family 4, sodium bicarbonate cotransporter, member 8	955					bicarbonate transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(18)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|stomach(2)|urinary_tract(5)	55				BRCA - Breast invasive adenocarcinoma(357;0.15)		TGCACCTCTTCACCCTCATCC	0.498000													14	66					0	0	1	0	0
DCAF4L2	138009	broad.mit.edu	37	8	88885093	88885093	+	Silent	SNP	A	A	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr8:88885093A>C	ENST00000319675.3	-	1	1203	c.1107T>G	c.(1105-1107)tcT>tcG	p.S369S		NM_152418.3	NP_689631.1	Q8NA75	DC4L2_HUMAN	DDB1 and CUL4 associated factor 4-like 2	369										breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|liver(2)|lung(40)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	83						CGAGGCGAGAAGAGAAGGCCA	0.592000													13	50					0	0	1	0	0
OR51B6	390058	broad.mit.edu	37	11	5373372	5373372	+	Missense_Mutation	SNP	T	T	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr11:5373372T>C	ENST00000380219.1	+	1	635	c.635T>C	c.(634-636)aTc>aCc	p.I212T	HBG2_ENST00000380252.1_Intron|HBE1_ENST00000380237.1_Intron|AC104389.28_ENST00000415970.1_RNA|HBG2_ENST00000380259.2_Intron	NM_001004750.1	NP_001004750.1	Q9H340	O51B6_HUMAN	olfactory receptor, family 51, subfamily B, member 6	212					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(10)|ovary(1)|skin(2)|urinary_tract(1)	21		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TTTCTCATCATCTTTTTCTCC	0.448000													16	49					0	0	1	0	0
PPFIA3	8541	broad.mit.edu	37	19	49652940	49652940	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr19:49652940C>T	ENST00000334186.4	+	28	3840	c.3491C>T	c.(3490-3492)tCt>tTt	p.S1164F	PPFIA3_ENST00000602351.1_Missense_Mutation_p.S1155F	NM_003660.2	NP_003651.1	O75145	LIPA3_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3	1164						cell surface|cytoplasm	protein binding	p.G1160fs*>21(2)|p.S1164F(1)		NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(16)|pancreas(1)|prostate(1)|skin(4)|urinary_tract(1)	35		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.36e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000203)|GBM - Glioblastoma multiforme(486;0.00307)|Epithelial(262;0.00677)		GCCCTGGGCTCTCCGGGGCTC	0.652000													5	37					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152719867	152719867	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr6:152719867C>G	ENST00000341594.5	-	52	7952	c.7351G>C	c.(7351-7353)Gag>Cag	p.E2451Q	SYNE1_ENST00000367255.5_Splice_Site|SYNE1_ENST00000423061.1_Splice_Site|SYNE1_ENST00000265368.4_Splice_Site|SYNE1_ENST00000448038.1_Splice_Site			Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2413					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TGCATAGACTCTTTTGAAAGa	0.368000										HNSCC(10;0.0054)			10	30					0	0	1	0	0
MYO10	4651	broad.mit.edu	37	5	16794760	16794760	+	Silent	SNP	G	G	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr5:16794760G>T	ENST00000513610.1	-	4	916	c.462C>A	c.(460-462)ctC>ctA	p.L154L		NM_012334.2	NP_036466.2	Q9HD67	MYO10_HUMAN	myosin X	154	Myosin head-like.				axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|lung(28)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	86						GTTACCTGATGAGGATGCACT	0.647000													6	17					0.00116845	0.00118324	1	1	0
GRIK1	2897	broad.mit.edu	37	21	30909552	30909552	+	Silent	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr21:30909552C>T	ENST00000399914.1	-	17	3325	c.2804G>A	c.(2803-2805)tGa>tAa	p.*935*	GRIK1_ENST00000535441.1_Silent_p.*923*|GRIK1_ENST00000327783.4_Silent_p.*950*|GRIK1_ENST00000389125.3_Silent_p.*906*|GRIK1_ENST00000399913.1_Silent_p.*921*			P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	0					central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(18)|ovary(1)|prostate(4)|skin(1)|stomach(1)|urinary_tract(1)	45					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	TTCCTTGGATCACGCCACAGT	0.383000													7	22					0	0	1	0	0
CYP2B7P	1556	broad.mit.edu	37	19	41448092	41448092	+	RNA	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr19:41448092C>G	ENST00000599198.1	+	0	999					NR_001278.1															NS(1)|endometrium(6)|kidney(1)|lung(2)|ovary(1)|skin(1)	12						TGCTCATGCTCAAATACCCTC	0.567000													10	49					0	0	1	0	0
HECW2	57520	broad.mit.edu	37	2	197184440	197184440	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr2:197184440G>C	ENST00000260983.2	-	9	1356	c.1174C>G	c.(1174-1176)Ctg>Gtg	p.L392V	HECW2_ENST00000409111.1_Missense_Mutation_p.L36V	NM_020760.1	NP_065811.1	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	392					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(24)|lung(45)|ovary(5)|pancreas(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	113						TCTATTTCCAGAGTGGAGCTA	0.502000													11	69					0	0	1	0	0
FAM172A	83989	broad.mit.edu	37	5	92956773	92956773	+	Nonsense_Mutation	SNP	C	C	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr5:92956773C>A	ENST00000395965.3	-	11	1313	c.1171G>T	c.(1171-1173)Gaa>Taa	p.E391*	FAM172A_ENST00000509739.1_Nonsense_Mutation_p.E244*|FAM172A_ENST00000509163.1_Nonsense_Mutation_p.E345*|FAM172A_ENST00000505869.1_Nonsense_Mutation_p.E281*	NM_032042.5	NP_114431.2	Q8WUF8	F172A_HUMAN	family with sequence similarity 172, member A	391						endoplasmic reticulum|extracellular region				endometrium(2)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(1)	9						TCTGAGGCTTCGGTAAAGAAT	0.577000													9	51					2.17888e-05	2.23475e-05	1	1	0
DPYSL3	1809	broad.mit.edu	37	5	146785192	146785192	+	Silent	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr5:146785192G>A	ENST00000343218.5	-	8	1331	c.1134C>T	c.(1132-1134)atC>atT	p.I378I	DPYSL3_ENST00000534907.1_Intron|DPYSL3_ENST00000398514.3_Silent_p.I264I	NM_001197294.1	NP_001184223.1	Q14195	DPYL3_HUMAN	dihydropyrimidinase-like 3	264					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol|growth cone	dihydropyrimidinase activity			breast(2)|endometrium(1)|kidney(4)|large_intestine(6)|liver(1)|lung(9)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGCTTGTGAGATGAGGTCAG	0.507000													50	214					0	0	1	0	0
ZNF845	91664	broad.mit.edu	37	19	53856028	53856028	+	Silent	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr19:53856028C>T	ENST00000458035.1	+	4	2217	c.2100C>T	c.(2098-2100)ttC>ttT	p.F700F	ZNF845_ENST00000595091.1_Silent_p.F700F	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	700				Missing (in Ref. 1; BAG58121).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						GCAAGACCTTCGGTCGAAATT	0.438000													62	105					0	0	1	0	0
TBC1D8	11138	broad.mit.edu	37	2	101675982	101675982	+	Silent	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr2:101675982G>A	ENST00000409318.1	-	3	433	c.303C>T	c.(301-303)atC>atT	p.I101I	TBC1D8_ENST00000376840.4_Silent_p.I86I	NM_001102426.1	NP_001095896.1	O95759	TBCD8_HUMAN	TBC1 domain family, member 8 (with GRAM domain)	86					blood circulation|positive regulation of cell proliferation	intracellular|membrane	calcium ion binding|Rab GTPase activator activity			breast(1)|cervix(1)|endometrium(8)|kidney(3)|large_intestine(2)|lung(12)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	32						AGTGCTGATTGATTTCCTCTA	0.368000													18	78					0	0	1	0	0
SLIT2	9353	broad.mit.edu	37	4	20530620	20530620	+	Missense_Mutation	SNP	T	T	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr4:20530620T>C	ENST00000504154.1	+	16	1763	c.1511T>C	c.(1510-1512)cTg>cCg	p.L504P	SLIT2_ENST00000503823.1_Missense_Mutation_p.L496P|SLIT2_ENST00000273739.5_Missense_Mutation_p.L508P|SLIT2_ENST00000503837.1_Missense_Mutation_p.L500P	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	504	LRRNT 3.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						TTTGCGGATCTGGCTTGCCCT	0.408000													18	61					0	0	1	0	0
NGLY1	55768	broad.mit.edu	37	3	25773966	25773966	+	Silent	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr3:25773966C>T	ENST00000428257.1	-	9	1322	c.1215G>A	c.(1213-1215)ctG>ctA	p.L405L	NGLY1_ENST00000422724.2_3'UTR|NGLY1_ENST00000467224.1_Intron|NGLY1_ENST00000417874.2_Silent_p.L381L|NGLY1_ENST00000280700.5_Silent_p.L423L|NGLY1_ENST00000396649.3_Silent_p.L423L	NM_001145293.1	NP_001138765.1	Q96IV0	NGLY1_HUMAN	N-glycanase 1	423					glycoprotein catabolic process	cytoplasm	metal ion binding|peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity|protein binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(7)|prostate(2)|skin(1)	18						CTGACAAAAACAGTTGCCTCT	0.353000													8	32					0	0	1	0	0
FMO1	2326	broad.mit.edu	37	1	171251239	171251239	+	Nonsense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr1:171251239C>G	ENST00000354841.4	+	6	1081	c.950C>G	c.(949-951)tCa>tGa	p.S317*	FMO1_ENST00000402921.2_Nonsense_Mutation_p.S254*|FMO1_ENST00000469112.1_3'UTR|FMO1_ENST00000367750.3_Nonsense_Mutation_p.S317*			Q01740	FMO1_HUMAN	flavin containing monooxygenase 1	317					NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum lumen|integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|prostate(2)|skin(2)	27	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					AACAATACTTCAAAGGAAGAG	0.428000													35	59					0	0	1	0	0
ITSN2	50618	broad.mit.edu	37	2	24431985	24431985	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr2:24431985C>G	ENST00000355123.4	-	36	5022	c.4579G>C	c.(4579-4581)Gac>Cac	p.D1527H	ITSN2_ENST00000361999.3_Missense_Mutation_p.D1500H	NM_006277.2	NP_006268.2	Q9NZM3	ITSN2_HUMAN	intersectin 2	1527	PH.				endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(8)|large_intestine(11)|liver(3)|lung(28)|ovary(2)|stomach(1)	61	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTAATGTTGTCTGTTCGGAGG	0.532000													8	44					0	0	1	0	0
SH3D21	79729	broad.mit.edu	37	1	36785936	36785936	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr1:36785936G>A	ENST00000453908.2	+	14	1700	c.1672G>A	c.(1672-1674)Gac>Aac	p.D558N	SH3D21_ENST00000312808.4_Missense_Mutation_p.D204N|SH3D21_ENST00000474766.1_3'UTR|SH3D21_ENST00000426732.2_Missense_Mutation_p.D442N|SH3D21_ENST00000505871.1_Missense_Mutation_p.D447N	NM_001162530.1	NP_001156002.1	A4FU49	SH321_HUMAN	SH3 domain containing 21	442										endometrium(1)|large_intestine(6)|lung(4)|pancreas(1)	12						AGTTAGAGGGGACAGCTCCCC	0.622000													23	108					0	0	1	0	0
DSG2	1829	broad.mit.edu	37	18	29126500	29126500	+	Missense_Mutation	SNP	C	C	G	rs2848674		TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr18:29126500C>G	ENST00000261590.8	+	15	3360	c.3151C>G	c.(3151-3153)Cta>Gta	p.L1051V	RP11-75N4.2_ENST00000583706.1_RNA	NM_001943.3	NP_001934.2	Q14126	DSG2_HUMAN	desmoglein 2	1051					cellular component disassembly involved in apoptosis|homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			breast(2)|central_nervous_system(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(17)|ovary(2)|prostate(4)|skin(2)|urinary_tract(1)	49			OV - Ovarian serous cystadenocarcinoma(10;0.0068)			AGAAAGAGTTCTAGCACCTGC	0.527000													15	79					0	0	1	0	0
PADI4	23569	broad.mit.edu	37	1	17657605	17657605	+	Silent	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr1:17657605G>A	ENST00000375448.4	+	2	260	c.234G>A	c.(232-234)ctG>ctA	p.L78L	PADI4_ENST00000375453.1_Silent_p.L78L|AC004824.2_ENST00000602074.1_Intron	NM_012387.2	NP_036519.2	Q9UM07	PADI4_HUMAN	peptidyl arginine deiminase, type IV	78					chromatin modification|peptidyl-citrulline biosynthetic process from peptidyl-arginine|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(13)|ovary(2)|skin(2)|urinary_tract(3)	26		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000338)|Lung NSC(340;0.00042)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00537)|BRCA - Breast invasive adenocarcinoma(304;8.54e-06)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(64;0.000223)|KIRC - Kidney renal clear cell carcinoma(64;0.00313)|STAD - Stomach adenocarcinoma(196;0.00707)|READ - Rectum adenocarcinoma(331;0.0689)|Lung(427;0.199)	L-Citrulline(DB00155)	AGGTGACCCTGACGATGAAAG	0.612000													4	87					0	0	1	0	0
SRPK2	6733	broad.mit.edu	37	7	104782803	104782803	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr7:104782803C>G	ENST00000357311.3	-	10	1333	c.1162G>C	c.(1162-1164)Gag>Cag	p.E388Q	SRPK2_ENST00000489828.1_Missense_Mutation_p.E388Q|SRPK2_ENST00000393651.3_Missense_Mutation_p.E399Q	NM_001278273.1|NM_182691.1	NP_001265202.1|NP_872633.1	P78362	SRPK2_HUMAN	SRSF protein kinase 2	388	Protein kinase.				angiogenesis|cell differentiation|intracellular protein kinase cascade|negative regulation of viral genome replication|nuclear speck organization|positive regulation of cell cycle|positive regulation of cell proliferation|positive regulation of gene expression|positive regulation of neuron apoptosis|positive regulation of viral genome replication|spliceosome assembly	cytoplasm|nucleolus	14-3-3 protein binding|ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(1)|kidney(11)|large_intestine(6)|lung(4)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	35						GGGCCATTCTCAATATGGCCA	0.413000													16	71					0	0	1	0	0
LRIT3	345193	broad.mit.edu	37	4	110791001	110791001	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr4:110791001G>A	ENST00000327908.3	+	4	1311	c.547G>A	c.(547-549)Gag>Aag	p.E183K	LRIT3_ENST00000379920.3_Missense_Mutation_p.E321K|LRIT3_ENST00000409621.2_Missense_Mutation_p.E183K|LRIT3_ENST00000594814.1_Missense_Mutation_p.E366K			Q3SXY7	LRIT3_HUMAN	leucine-rich repeat, immunoglobulin-like and transmembrane domains 3	321	LRRCT.					integral to membrane				cervix(1)|kidney(1)|large_intestine(3)|lung(8)|prostate(2)|skin(1)	16				OV - Ovarian serous cystadenocarcinoma(123;0.0011)		AGATCATCCTGAGTGGGATGT	0.483000													26	130					0	0	1	0	0
TCHH	7062	broad.mit.edu	37	1	152081624	152081624	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr1:152081624C>G	ENST00000368804.1	-	2	4068	c.4069G>C	c.(4069-4071)Gag>Cag	p.E1357Q		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	1357	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGTCACGCTCTTGGCGGCGC	0.577000													60	256					0	0	1	0	0
ODF3B	440836	broad.mit.edu	37	22	50969674	50969674	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr22:50969674G>A	ENST00000329363.4	-	4	500	c.364C>T	c.(364-366)Cgg>Tgg	p.R122W	ODF3B_ENST00000428989.2_Missense_Mutation_p.R122W|ODF3B_ENST00000405135.1_Missense_Mutation_p.S137L|ODF3B_ENST00000403326.1_Missense_Mutation_p.R54W|ODF3B_ENST00000401779.1_Missense_Mutation_p.S98L	NM_001014440.3	NP_001014440.2	A8MYP8	ODF3B_HUMAN	outer dense fiber of sperm tails 3B	122										lung(2)	2						ATGGTGTGCCGAGGCGCACTG	0.672000													11	27					0	0	1	0	0
MARCH4	57574	broad.mit.edu	37	2	217148387	217148387	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr2:217148387G>C	ENST00000273067.4	-	2	2348	c.582C>G	c.(580-582)atC>atG	p.I194M		NM_020814.2	NP_065865.1	Q9P2E8	MARH4_HUMAN	membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase	194						Golgi membrane|Golgi stack|integral to membrane|trans-Golgi network	ubiquitin-protein ligase activity|zinc ion binding			breast(1)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)|skin(1)	20		Renal(323;0.0854)		Epithelial(149;2.19e-05)|all cancers(144;0.00121)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(261;0.0125)		TGATCCACTTGATGAGGCAAG	0.582000													11	54					0	0	1	0	0
MYO9A	4649	broad.mit.edu	37	15	72143611	72143611	+	Silent	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr15:72143611G>A	ENST00000356056.5	-	37	7036	c.6564C>T	c.(6562-6564)ctC>ctT	p.L2188L	MYO9A_ENST00000444904.1_Silent_p.L2169L|MYO9A_ENST00000424560.1_Silent_p.L2259L|MYO9A_ENST00000564571.1_Silent_p.L2188L	NM_006901.3	NP_008832.2	B2RTY4	MYO9A_HUMAN	myosin IXA	2188	Rho-GAP.|Tail.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(29)|lung(27)|ovary(1)|pancreas(1)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						GATGAAAGATGAGGCGTTCCA	0.383000													4	28					0	0	1	0	0
MYO16	23026	broad.mit.edu	37	13	109699313	109699313	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr13:109699313C>T	ENST00000356711.2	+	24	2906	c.2780C>T	c.(2779-2781)tCa>tTa	p.S927L	MYO16_ENST00000357550.2_Missense_Mutation_p.S927L|MYO16_ENST00000457511.2_Missense_Mutation_p.S439L|MYO16_ENST00000251041.5_Missense_Mutation_p.S927L	NM_015011.1	NP_055826.1	Q9Y6X6	MYO16_HUMAN	myosin XVI	927	Myosin head-like 2.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			NS(3)|breast(4)|central_nervous_system(2)|endometrium(10)|kidney(8)|large_intestine(27)|lung(51)|ovary(9)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	121	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			GACTCCCTTTCACAGAATCTT	0.318000													10	45					0	0	1	0	0
SCYL3	57147	broad.mit.edu	37	1	169845188	169845188	+	Silent	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr1:169845188C>T	ENST00000367772.4	-	4	593	c.396G>A	c.(394-396)gtG>gtA	p.V132V	SCYL3_ENST00000367771.5_Silent_p.V132V|SCYL3_ENST00000470238.1_5'UTR|SCYL3_ENST00000367770.1_Silent_p.V132V	NM_181093.3	NP_851607.2	Q8IZE3	PACE1_HUMAN	SCY1-like 3 (S. cerevisiae)	132	Protein kinase.				cell migration	Golgi apparatus|lamellipodium	ATP binding|protein binding|protein kinase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(5)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CATCTTCACTCACAAACACAG	0.443000													21	50					0	0	1	0	0
TPTE	7179	broad.mit.edu	37	21	10951388	10951388	+	Silent	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr21:10951388G>A	ENST00000298232.7	-	9	637	c.270C>T	c.(268-270)ctC>ctT	p.L90L	TPTE_ENST00000361285.4_Silent_p.L108L|TPTE_ENST00000342420.5_Silent_p.L70L|TPTE_ENST00000415664.2_5'UTR	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	108					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CGGCAAGGATGAGAGTGACAT	0.333000													17	120					0	0	1	0	0
CD226	10666	broad.mit.edu	37	18	67562982	67562982	+	Missense_Mutation	SNP	C	C	T	rs146723371	byFrequency	TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr18:67562982C>T	ENST00000280200.4	-	4	950	c.682G>A	c.(682-684)Gca>Aca	p.A228T	CD226_ENST00000582621.1_Missense_Mutation_p.A228T|CD226_ENST00000581982.1_Missense_Mutation_p.A73T|CD226_ENST00000577287.1_Missense_Mutation_p.A73T	NM_006566.2	NP_006557.2	Q15762	CD226_HUMAN	CD226 molecule	228	Ig-like C2-type 2.				cell adhesion|cell recognition|positive regulation of Fc receptor mediated stimulatory signaling pathway|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	cell surface|integral to plasma membrane|membrane raft	cell adhesion molecule binding|integrin binding|protein kinase binding|receptor activity	p.A228T(1)		breast(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(14)|prostate(1)|urinary_tract(1)	24		Esophageal squamous(42;0.129)				TTTTCTCCTGCGCTGGCCTGC	0.542000													5	171					0	0	1	0	0
TMEM155	132332	broad.mit.edu	37	4	122682803	122682803	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr4:122682803C>G	ENST00000337677.5	-	5	660	c.102G>C	c.(100-102)caG>caC	p.Q34H	TMEM155_ENST00000394394.1_Missense_Mutation_p.Q34H|TMEM155_ENST00000394396.1_Missense_Mutation_p.Q34H	NM_152399.2	NP_689612.2	Q4W5P6	TM155_HUMAN	transmembrane protein 155	34						extracellular region				breast(1)|lung(5)	6						CTCTCTTATTCTGTAGAATCG	0.423000													10	30					0	0	1	0	0
TCHH	7062	broad.mit.edu	37	1	152082282	152082282	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr1:152082282C>G	ENST00000368804.1	-	2	3410	c.3411G>C	c.(3409-3411)gaG>gaC	p.E1137D		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	1137	10 X 30 AA tandem repeats.				keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			gatattgcctctccagctcct	0.607000													23	105					0	0	1	0	0
SPP2	6694	broad.mit.edu	37	2	234978605	234978605	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr2:234978605G>A	ENST00000168148.3	+	7	672	c.584G>A	c.(583-585)aGa>aAa	p.R195K	SPP2_ENST00000373368.1_Missense_Mutation_p.R195K	NM_006944.2	NP_008875.1	Q13103	SPP24_HUMAN	secreted phosphoprotein 2, 24kDa	195					bone remodeling|skeletal system development	extracellular region	endopeptidase inhibitor activity			breast(1)|kidney(1)|large_intestine(2)|lung(6)|prostate(1)|skin(1)	12		Breast(86;0.0109)|Renal(207;0.019)|all_lung(227;0.13)|all_hematologic(139;0.182)		Epithelial(121;5.73e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000166)|Lung(119;0.00539)|LUSC - Lung squamous cell carcinoma(224;0.00846)		CCTGGAAACAGAAGGTACCCA	0.438000													12	44					0	0	1	0	0
USP53	54532	broad.mit.edu	37	4	120194844	120194844	+	Silent	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr4:120194844G>A	ENST00000450251.1	+	13	2776	c.2232G>A	c.(2230-2232)caG>caA	p.Q744Q	USP53_ENST00000274030.6_Silent_p.Q744Q			Q70EK8	UBP53_HUMAN	ubiquitin specific peptidase 53	744					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(5)|ovary(1)|pancreas(1)|skin(2)|stomach(1)	27						CCTCCCTTCAGAGCCAACATC	0.323000													4	28					0	0	1	0	0
ZFP91	80829	broad.mit.edu	37	11	58384768	58384768	+	Silent	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr11:58384768C>T	ENST00000316059.6	+	11	1473	c.1302C>T	c.(1300-1302)atC>atT	p.I434I	ZFP91-CNTF_ENST00000389919.4_Silent_p.I434I	NM_001197051.1|NM_053023.4	NP_001183980.1|NP_444251.1	Q96JP5	ZFP91_HUMAN	ZFP91 zinc finger protein	434					activation of NF-kappaB-inducing kinase activity|protein K63-linked ubiquitination	nucleus	nucleic acid binding|ubiquitin-protein ligase activity|zinc ion binding			cervix(1)|endometrium(4)|kidney(4)|large_intestine(4)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	26		Breast(21;0.00725)|all_epithelial(135;0.0101)|all_lung(304;0.24)				CTTGCAATATCTGTGGCAAAA	0.458000													14	38					0	0	1	0	0
HUWE1	10075	broad.mit.edu	37	X	53577973	53577973	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chrX:53577973C>T	ENST00000342160.3	-	64	9731	c.9274G>A	c.(9274-9276)Gag>Aag	p.E3092K	HUWE1_ENST00000262854.6_Missense_Mutation_p.E3092K			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	3092					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						GCTTGAGCCTCAGCTGCAATG	0.562000													20	23					0	0	1	0	0
PHF1	5252	broad.mit.edu	37	6	33383784	33383784	+	Missense_Mutation	SNP	G	G	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr6:33383784G>T	ENST00000374516.3	+	15	1884	c.1613G>T	c.(1612-1614)cGa>cTa	p.R538L	PHF1_ENST00000374512.3_3'UTR	NM_024165.2	NP_077084.1	O43189	PHF1_HUMAN	PHD finger protein 1	538					chromatin modification	nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(1)|lung(5)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	19		Ovarian(999;0.0443)				TACCTGTCCCGAGGGGACCCT	0.632000													6	153					0.00116845	0.00118324	1	1	0
USP20	10868	broad.mit.edu	37	9	132637139	132637139	+	Silent	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr9:132637139G>A	ENST00000315480.4	+	19	2111	c.1953G>A	c.(1951-1953)gtG>gtA	p.V651V	USP20_ENST00000372429.3_Silent_p.V651V|USP20_ENST00000358355.1_Silent_p.V651V			Q9Y2K6	UBP20_HUMAN	ubiquitin specific peptidase 20	651					endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|ubiquitin thiolesterase activity|zinc ion binding			breast(1)|endometrium(2)|large_intestine(3)|lung(4)|urinary_tract(1)	11		Ovarian(14;0.00556)				GCCAGAACGTGATCAATGGGC	0.602000													14	32					0	0	1	0	0
FRG1BP	284802	broad.mit.edu	37	20	29628282	29628282	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr20:29628282G>A	ENST00000278882.3	+	6	664	c.284G>A	c.(283-285)gGg>gAg	p.G95E	FRG1B_ENST00000358464.4_Missense_Mutation_p.G95E|FRG1B_ENST00000439954.2_Missense_Mutation_p.G100E																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						AATGAAGCAGGGGACATAGAA	0.373000													4	124					0	0	1	0	0
KIDINS220	57498	broad.mit.edu	37	2	8890432	8890432	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr2:8890432C>G	ENST00000256707.3	-	24	3405	c.3224G>C	c.(3223-3225)gGa>gCa	p.G1075A	KIDINS220_ENST00000473731.1_Missense_Mutation_p.G1075A|KIDINS220_ENST00000427284.1_Missense_Mutation_p.G1075A|KIDINS220_ENST00000418530.1_Missense_Mutation_p.G1033A	NM_020738.2	NP_065789.1	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate, 220kDa	1075					activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(25)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	60	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					CGCCAGTCCTCCAATACTGAT	0.532000													12	34					0	0	1	0	0
MT-ND1	4535	broad.mit.edu	37	MT	3786	3786	+	Missense_Mutation	SNP	T	T	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chrM:3786T>C	ENST00000361390.2	+	1	480	c.480T>C	c.(478-480)ttT>ttC	p.160_160insF						mitochondrially encoded NADH dehydrogenase 1											breast(1)|endometrium(13)|kidney(17)|lung(2)|prostate(1)	34						AGTGGCTCCTTTAACCTCTCC	0.458000													15	11					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128488768	128488768	+	Silent	SNP	C	C	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr7:128488768C>A	ENST00000325888.8	+	27	4995	c.4734C>A	c.(4732-4734)atC>atA	p.I1578I	FLNC_ENST00000346177.6_Silent_p.I1578I	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	1578					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						CTGTCCAGATCTTGGTGAGTC	0.657000													8	137					0.0477658	0.0480058	1	1	0
PTPRU	10076	broad.mit.edu	37	1	29586053	29586053	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr1:29586053G>A	ENST00000373779.3	+	5	781	c.652G>A	c.(652-654)Gag>Aag	p.E218K	PTPRU_ENST00000460170.2_Missense_Mutation_p.E218K|PTPRU_ENST00000428026.2_Missense_Mutation_p.E218K|PTPRU_ENST00000345512.3_Missense_Mutation_p.E218K|PTPRU_ENST00000356870.3_Missense_Mutation_p.E218K|PTPRU_ENST00000323874.8_Missense_Mutation_p.E218K	NM_001195001.1|NM_133178.3	NP_001181930.1|NP_573439.2	Q92729	PTPRU_HUMAN	protein tyrosine phosphatase, receptor type, U	218	Ig-like C2-type.				canonical Wnt receptor signaling pathway|cell differentiation|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transmembrane receptor protein tyrosine phosphatase signaling pathway	cell-cell junction|integral to plasma membrane	beta-catenin binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(26)|ovary(1)|prostate(3)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	79		Colorectal(325;0.000399)|Lung NSC(340;0.00953)|all_lung(284;0.0112)|Breast(348;0.0126)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;6.99e-07)|COAD - Colon adenocarcinoma(152;3.18e-05)|STAD - Stomach adenocarcinoma(196;0.0234)|READ - Rectum adenocarcinoma(331;0.0686)|BRCA - Breast invasive adenocarcinoma(304;0.0871)		CAGAGCGGCCGAGGCCGAACG	0.701000													8	32					0	0	1	0	0
ZDHHC16	84287	broad.mit.edu	37	10	99214507	99214507	+	Nonsense_Mutation	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr10:99214507C>T	ENST00000393760.1	+	9	1124	c.775C>T	c.(775-777)Cga>Tga	p.R259*	ZDHHC16_ENST00000352634.4_Nonsense_Mutation_p.R243*|ZDHHC16_ENST00000370854.3_Nonsense_Mutation_p.R259*|ZDHHC16_ENST00000345745.5_Nonsense_Mutation_p.R178*|ZDHHC16_ENST00000370842.2_Nonsense_Mutation_p.R243*|ZDHHC16_ENST00000353979.3_Nonsense_Mutation_p.R220*|ZDHHC16_ENST00000370846.4_Intron|ZDHHC16_ENST00000495735.1_3'UTR	NM_198046.1	NP_932163.1	Q969W1	ZDH16_HUMAN	zinc finger, DHHC-type containing 16	259					apoptosis	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity|zinc ion binding			kidney(4)|large_intestine(3)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	14		Colorectal(252;0.0846)		Epithelial(162;5.81e-10)|all cancers(201;4.19e-08)		CTTCTCCTTTCGAGAAAGGAT	0.463000													29	96					0	0	1	0	0
ALOX15B	247	broad.mit.edu	37	17	7950325	7950325	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr17:7950325G>A	ENST00000380183.4	+	10	1527	c.1388G>A	c.(1387-1389)cGa>cAa	p.R463Q	ALOX15B_ENST00000573359.1_Missense_Mutation_p.R434Q|ALOX15B_ENST00000380173.2_Missense_Mutation_p.R434Q|ALOX15B_ENST00000572022.1_Missense_Mutation_p.R463Q	NM_001141.2	NP_001132.2	O15296	LX15B_HUMAN	arachidonate 15-lipoxygenase, type B	463	Lipoxygenase.				induction of apoptosis|leukotriene biosynthetic process|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of growth|prostate gland development|regulation of epithelial cell differentiation	cytoplasm	arachidonate 15-lipoxygenase activity|iron ion binding|lipoxygenase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(3)|ovary(1)|prostate(2)|skin(2)|stomach(4)|upper_aerodigestive_tract(1)	24						ATCCGGACCCGAGGAGTTGAA	0.557000													10	48					0	0	1	0	0
SOWAHA	134548	broad.mit.edu	37	5	132150735	132150735	+	Silent	SNP	C	C	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr5:132150735C>A	ENST00000378693.2	+	1	1703	c.1422C>A	c.(1420-1422)tcC>tcA	p.S474S		NM_175873.4	NP_787069.3	Q2M3V2	ANR43_HUMAN	sosondowah ankyrin repeat domain family member A	474																	TCCTCAGTTCCACCACCAGTG	0.637000													11	17					9.70103e-10	1.03202e-09	1	1	0
EPB41L3	23136	broad.mit.edu	37	18	5434087	5434087	+	Silent	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr18:5434087G>A	ENST00000341928.2	-	7	979	c.639C>T	c.(637-639)atC>atT	p.I213I	EPB41L3_ENST00000544123.1_Silent_p.I213I|EPB41L3_ENST00000540638.2_Silent_p.I213I|EPB41L3_ENST00000342933.3_Silent_p.I213I|EPB41L3_ENST00000400111.3_Silent_p.I213I|EPB41L3_ENST00000542652.2_5'UTR	NM_012307.2	NP_036439.2	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	213	FERM.				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(52)|ovary(5)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	105						TTCCGGACACGATGTCATCTC	0.542000													16	63					0	0	1	0	0
ACTR5	79913	broad.mit.edu	37	20	37380805	37380805	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr20:37380805C>G	ENST00000243903.4	+	3	674	c.637C>G	c.(637-639)Ctt>Gtt	p.L213V		NM_024855.3	NP_079131.3	Q9H9F9	ARP5_HUMAN	ARP5 actin-related protein 5 homolog (yeast)	213					DNA recombination|double-strand break repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent|UV-damage excision repair	cytoplasm|Ino80 complex	ATP binding|protein binding			kidney(2)|large_intestine(2)|liver(1)|lung(5)|skin(2)	12		Myeloproliferative disorder(115;0.00878)				GCGCATCAATCTTGGAGGAAG	0.498000													12	35					0	0	1	0	0
SUN5	140732	broad.mit.edu	37	20	31590714	31590714	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr20:31590714C>T	ENST00000356173.3	-	2	181	c.89G>A	c.(88-90)cGa>cAa	p.R30Q	SUN5_ENST00000375523.3_Missense_Mutation_p.R30Q|SUN5_ENST00000375519.2_Missense_Mutation_p.R30Q	NM_080675.3	NP_542406.2	Q8TC36	SUN5_HUMAN	Sad1 and UNC84 domain containing 5	30					spermatogenesis					endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	25						GTTCCGGCCTCGCTGGGCAAT	0.517000													5	59					0	0	1	0	0
GSS	2937	broad.mit.edu	37	20	33529623	33529623	+	Silent	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr20:33529623G>A	ENST00000216951.2	-	6	599	c.501C>T	c.(499-501)ctC>ctT	p.L167L	GSS_ENST00000541098.1_Silent_p.L39L|GSS_ENST00000451957.2_Intron	NM_000178.2	NP_000169.1	P48637	GSHB_HUMAN	glutathione synthetase	167					nervous system development|response to oxidative stress|xenobiotic metabolic process	cytosol	ATP binding|glutathione binding|glutathione synthase activity|magnesium ion binding|protein homodimerization activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(6)|ovary(3)|upper_aerodigestive_tract(1)	17			BRCA - Breast invasive adenocarcinoma(18;0.035)		Glutathione(DB00143)|Glycine(DB00145)|L-Cysteine(DB00151)	TCAGGACACTGAGAACATGTC	0.502000													13	44					0	0	1	0	0
NADSYN1	55191	broad.mit.edu	37	11	71185569	71185569	+	Silent	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr11:71185569C>T	ENST00000319023.2	+	9	983	c.795C>T	c.(793-795)gaC>gaT	p.D265D		NM_018161.4	NP_060631.2	Q6IA69	NADE_HUMAN	NAD synthetase 1	265	CN hydrolase.				NAD biosynthetic process|water-soluble vitamin metabolic process	cytosol	ATP binding|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|NAD+ synthase (glutamine-hydrolyzing) activity|protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	25					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	CTCTGGATGACGTGGTAATGA	0.597000													21	84					0	0	1	0	0
WDR60	55112	broad.mit.edu	37	7	158716345	158716345	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr7:158716345G>C	ENST00000407559.3	+	17	2336	c.2178G>C	c.(2176-2178)ttG>ttC	p.L726F		NM_018051.4	NP_060521.4	Q8WVS4	WDR60_HUMAN	WD repeat domain 60	726										NS(3)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(2)|liver(4)|lung(16)|ovary(2)	35	Ovarian(565;0.152)	all_cancers(7;1.25e-09)|all_epithelial(9;0.000894)|all_hematologic(28;0.00603)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)|STAD - Stomach adenocarcinoma(7;0.18)		TCTGGGATTTGAGAGAAGACT	0.532000													35	112					0	0	1	0	0
FAM83C	128876	broad.mit.edu	37	20	33875192	33875192	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr20:33875192G>A	ENST00000374408.3	-	4	1486	c.1390C>T	c.(1390-1392)Cgg>Tgg	p.R464W		NM_178468.5	NP_848563.1	Q9BQN1	FA83C_HUMAN	family with sequence similarity 83, member C	464								p.R464W(1)		central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(18;0.00252)			TCTGGGAACCGGGACAGAGCT	0.632000													11	35					0	0	1	0	0
TP53BP1	7158	broad.mit.edu	37	15	43748812	43748812	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr15:43748812G>A	ENST00000263801.3	-	12	2231	c.1979C>T	c.(1978-1980)tCa>tTa	p.S660L	TP53BP1_ENST00000382039.3_Missense_Mutation_p.S665L|TP53BP1_ENST00000382044.4_Missense_Mutation_p.S665L|TP53BP1_ENST00000450115.2_Missense_Mutation_p.S665L	NM_005657.2	NP_005648.1	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1	660					double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			breast(4)|endometrium(5)|kidney(7)|large_intestine(22)|lung(13)|ovary(4)|pancreas(2)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(3)	72		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		CTCAGACCCTGAAGACCCCTC	0.473000								Other conserved DNA damage response genes					30	108					0	0	1	0	0
MYH3	4621	broad.mit.edu	37	17	10541414	10541414	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr17:10541414G>C	ENST00000583535.1	-	27	3762	c.3675C>G	c.(3673-3675)ttC>ttG	p.F1225L	MYH3_ENST00000226209.7_Missense_Mutation_p.F1225L	NM_002470.3	NP_002461.2	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle, embryonic	1225					muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(5)|large_intestine(18)|lung(30)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	83						TCTCCAGCTTGAACTCGCTCT	0.572000													31	95					0	0	1	0	0
DNAJC13	23317	broad.mit.edu	37	3	132222099	132222099	+	Silent	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr3:132222099G>A	ENST00000260818.6	+	41	5006	c.4758G>A	c.(4756-4758)ctG>ctA	p.L1586L		NM_015268.3	NP_056083.3	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	1586							heat shock protein binding			breast(4)|endometrium(2)|kidney(2)|large_intestine(5)|lung(15)|ovary(1)|pancreas(2)|prostate(2)|urinary_tract(1)	34						TCCATGCTCTGAGTCGCCTTG	0.403000													9	78					0	0	1	0	0
WIZ	58525	broad.mit.edu	37	19	15533892	15533892	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr19:15533892G>C	ENST00000389282.4	-	10	5164	c.4951C>G	c.(4951-4953)Ccc>Gcc	p.P1651A	WIZ_ENST00000545156.1_Missense_Mutation_p.P965A|WIZ_ENST00000263381.6_Missense_Mutation_p.P794A|WIZ_ENST00000599910.1_Missense_Mutation_p.P968A|WIZ_ENST00000599686.2_Missense_Mutation_p.P835A			O95785	WIZ_HUMAN	widely interspaced zinc finger motifs	1651						nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|skin(1)|stomach(1)|urinary_tract(1)	24						TTGTGTTAGGGAGCCTCTGCC	0.582000													12	44					0	0	1	0	0
SAMD7	344658	broad.mit.edu	37	3	169644487	169644487	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr3:169644487C>T	ENST00000428432.2	+	6	826	c.437C>T	c.(436-438)cCt>cTt	p.P146L	SAMD7_ENST00000335556.3_Missense_Mutation_p.P146L	NM_182610.2	NP_872416.1	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	146										NS(1)|biliary_tract(1)|breast(1)|kidney(1)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	31	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)			AGCATGCTCCCTGCCGGTGAC	0.577000													28	130					0	0	1	0	0
XKR9	389668	broad.mit.edu	37	8	71619234	71619234	+	Silent	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr8:71619234C>T	ENST00000408926.3	+	4	873	c.339C>T	c.(337-339)ttC>ttT	p.F113F	XKR9_ENST00000520273.1_3'UTR|XKR9_ENST00000520030.1_Silent_p.F113F	NM_001011720.1	NP_001011720.1	Q5GH70	XKR9_HUMAN	XK, Kell blood group complex subunit-related family, member 9	113						integral to membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|liver(2)|lung(4)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	19	Breast(64;0.0716)		Epithelial(68;0.00301)|all cancers(69;0.0165)|OV - Ovarian serous cystadenocarcinoma(28;0.0524)|BRCA - Breast invasive adenocarcinoma(89;0.166)			CTAGTAACTTCGTGGAAGAAC	0.358000													4	41					0	0	1	0	0
HHATL	57467	broad.mit.edu	37	3	42740209	42740209	+	Silent	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr3:42740209G>A	ENST00000441594.1	-	5	735	c.474C>T	c.(472-474)atC>atT	p.I158I	HHATL_ENST00000310417.5_Silent_p.I158I	NM_020707.3	NP_065758.3	Q9HCP6	HHATL_HUMAN	hedgehog acyltransferase-like	158					negative regulation of N-terminal protein palmitoylation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm				NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(3)|prostate(3)	19				KIRC - Kidney renal clear cell carcinoma(284;0.215)		CCTGCCAAGAGATTAGGGGGT	0.567000													12	161					0	0	1	0	0
ITGAX	3687	broad.mit.edu	37	16	31382953	31382953	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr16:31382953G>A	ENST00000268296.4	+	17	2129	c.2008G>A	c.(2008-2010)Gac>Aac	p.D670N	ITGAX_ENST00000562522.1_Missense_Mutation_p.D670N	NM_000887.3	NP_000878.2	P20702	ITAX_HUMAN	integrin, alpha X (complement component 3 receptor 4 subunit)	670					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(42)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	77						GCCTACAGGTGACCTCCAAAG	0.632000													28	60					0	0	1	0	0
SLC26A1	10861	broad.mit.edu	37	4	985254	985254	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr4:985254C>T	ENST00000361661.2	-	3	615	c.238G>A	c.(238-240)Ggc>Agc	p.G80S	IDUA_ENST00000453894.1_Intron|SLC26A1_ENST00000398516.2_Missense_Mutation_p.G80S|IDUA_ENST00000247933.4_Intron|SLC26A1_ENST00000398520.2_Missense_Mutation_p.G80S	NM_213613.2	NP_998778.1	Q9H2B4	S26A1_HUMAN	solute carrier family 26 (anion exchanger), member 1	80						integral to membrane|plasma membrane	secondary active sulfate transmembrane transporter activity			central_nervous_system(1)|endometrium(4)|pancreas(1)|prostate(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			AGGATGATGCCGATGACCAGC	0.652000													35	112					0	0	1	0	0
ANKRD23	200539	broad.mit.edu	37	2	97507919	97507919	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr2:97507919C>G	ENST00000318357.4	-	3	219	c.178G>C	c.(178-180)Gaa>Caa	p.E60Q	ANKRD23_ENST00000331001.2_Missense_Mutation_p.E60Q|ANKRD23_ENST00000418232.1_Missense_Mutation_p.E60Q	NM_144994.7	NP_659431.5	Q86SG2	ANR23_HUMAN	ankyrin repeat domain 23	60						nucleus				endometrium(2)|kidney(1)|lung(4)|ovary(1)|prostate(1)	9						TTAAATCTTTCAAGCTGGGGC	0.532000													20	81					0	0	1	0	0
COL6A2	1292	broad.mit.edu	37	21	47532053	47532053	+	Silent	SNP	G	G	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr21:47532053G>C	ENST00000300527.4	+	3	380	c.276G>C	c.(274-276)ctG>ctC	p.L92L	COL6A2_ENST00000310645.5_Silent_p.L92L|COL6A2_ENST00000409416.1_Silent_p.L92L|COL6A2_ENST00000357838.4_Silent_p.L92L|COL6A2_ENST00000397763.1_Silent_p.L92L	NM_001849.3	NP_001840.3	P12110	CO6A2_HUMAN	collagen, type VI, alpha 2	92	Nonhelical region.|VWFA 1.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			NS(1)|breast(1)|central_nervous_system(7)|endometrium(7)|kidney(5)|liver(1)|lung(15)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	43	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		AGGTGGCGCTGAGCTGGCGCT	0.622000													14	62					0	0	1	0	0
SDF4	51150	broad.mit.edu	37	1	1158658	1158658	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr1:1158658G>C	ENST00000263741.7	-	4	835	c.543C>G	c.(541-543)atC>atG	p.I181M	SDF4_ENST00000360001.6_Missense_Mutation_p.I181M|SDF4_ENST00000545427.1_Missense_Mutation_p.I181M	NM_016176.3|NM_016547.2	NP_057260.2|NP_057631.1	Q9BRK5	CAB45_HUMAN	stromal cell derived factor 4	181					cerebellum development|fat cell differentiation|response to ethanol|UV protection|zymogen granule exocytosis	bleb|Golgi lumen|late endosome|soluble fraction	calcium ion binding|identical protein binding|protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	11	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;7.85e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.42e-21)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;4.83e-05)|Kidney(185;0.00252)|BRCA - Breast invasive adenocarcinoma(365;0.00263)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0368)|Lung(427;0.204)		CGTTGAGCCTGATGGCGTCGG	0.557000													28	75					0	0	1	0	0
ZNF234	10780	broad.mit.edu	37	19	44660827	44660827	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr19:44660827C>G	ENST00000426739.2	+	6	916	c.658C>G	c.(658-660)Caa>Gaa	p.Q220E	ZNF234_ENST00000592437.1_Missense_Mutation_p.Q220E	NM_006630.2	NP_006621.1	Q14588	ZN234_HUMAN	zinc finger protein 234	220					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(11)|ovary(1)|prostate(1)	23		Prostate(69;0.0435)				CTCACATCTTCAAACTCATCA	0.408000													51	155					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41557008	41557008	+	Silent	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr8:41557008C>T	ENST00000396942.1	-	23	2603	c.2520G>A	c.(2518-2520)gaG>gaA	p.E840E	ANK1_ENST00000396945.1_Silent_p.E840E|ANK1_ENST00000289734.7_Silent_p.E840E|ANK1_ENST00000265709.8_Silent_p.E881E|ANK1_ENST00000379758.2_Silent_p.E840E|ANK1_ENST00000352337.4_Silent_p.E840E|ANK1_ENST00000347528.4_Silent_p.E840E			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	840					axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			GCAGCTCCTTCTCTTCATCAA	0.577000													14	80					0	0	1	0	0
QSOX2	169714	broad.mit.edu	37	9	139110561	139110561	+	Silent	SNP	C	C	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr9:139110561C>A	ENST00000358701.5	-	8	1087	c.1050G>T	c.(1048-1050)ctG>ctT	p.L350L		NM_181701.3	NP_859052.3	Q6ZRP7	QSOX2_HUMAN	quiescin Q6 sulfhydryl oxidase 2	350					cell redox homeostasis	extracellular region|integral to membrane|nuclear membrane|plasma membrane	thiol oxidase activity			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(4)|prostate(1)|upper_aerodigestive_tract(1)	22		Myeloproliferative disorder(178;0.0511)		Epithelial(140;7.78e-08)|OV - Ovarian serous cystadenocarcinoma(145;1.55e-07)		TGAGCGTCTTCAGCTCTGCTC	0.612000													7	49					7.48243e-07	7.7942e-07	1	1	0
HOMER2	9455	broad.mit.edu	37	15	83561458	83561458	+	Silent	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr15:83561458G>A	ENST00000304231.8	-	2	333	c.141C>T	c.(139-141)atC>atT	p.I47I	HOMER2_ENST00000450735.2_Silent_p.I47I|HOMER2_ENST00000426485.1_Silent_p.I47I|HOMER2_ENST00000399166.2_Silent_p.I47I	NM_199330.2	NP_955362.1	Q9NSB8	HOME2_HUMAN	homer homolog 2 (Drosophila)	47	WH1.				metabotropic glutamate receptor signaling pathway	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane				cervix(1)|endometrium(2)|lung(6)	9						CCACACTGATGATCCGATAGC	0.498000													36	157					0	0	1	0	0
GANAB	23193	broad.mit.edu	37	11	62400964	62400964	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr11:62400964C>T	ENST00000346178.4	-	7	664	c.649G>A	c.(649-651)Gag>Aag	p.E217K	GANAB_ENST00000540933.1_Missense_Mutation_p.E98K|GANAB_ENST00000534779.1_Missense_Mutation_p.E103K|GANAB_ENST00000356638.3_Missense_Mutation_p.E195K|GANAB_ENST00000534422.1_5'UTR	NM_001278192.1|NM_198335.2	NP_001265121.1|NP_938149.2	Q14697	GANAB_HUMAN	glucosidase, alpha; neutral AB	195					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|ovary(3)|skin(2)|urinary_tract(3)	35						CCATCGCCCTCAGCTGGGTCT	0.627000													19	75					0	0	1	0	0
KATNAL2	83473	broad.mit.edu	37	18	44625615	44625615	+	Splice_Site	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr18:44625615G>A	ENST00000245121.5	+	13	1191	c.995_splice	c.e13-1	p.E333_splice	KATNAL2_ENST00000356157.7_Splice_Site_p.E405_splice	NM_031303.2	NP_112593.2	Q8IYT4	KATL2_HUMAN	katanin p60 subunit A-like 2	405						cytoplasm|microtubule	ATP binding|microtubule-severing ATPase activity			central_nervous_system(2)|endometrium(3)|large_intestine(8)|lung(8)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(2)	27						TGATTTCAGGGAGCTGGACTG	0.532000													18	68					0	0	1	0	0
MST1R	4486	broad.mit.edu	37	3	49924801	49924801	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr3:49924801G>A	ENST00000296474.3	-	20	4169	c.4142C>T	c.(4141-4143)tCa>tTa	p.S1381L	MST1R_ENST00000344206.4_Missense_Mutation_p.S1332L	NM_002447.2	NP_002438.2	Q04912	RON_HUMAN	macrophage stimulating 1 receptor (c-met-related tyrosine kinase)	1381					cellular component movement|defense response|multicellular organismal development|positive regulation of cell proliferation|single fertilization|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|macrophage colony-stimulating factor receptor activity|protein binding			cervix(1)|endometrium(5)|large_intestine(3)|lung(17)|ovary(5)|prostate(2)|skin(1)|urinary_tract(3)	37				BRCA - Breast invasive adenocarcinoma(193;4.65e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00553)|Kidney(197;0.00625)		TGGCATGGGTGAGAACTGCGG	0.592000													35	119					0	0	1	0	0
GTPBP8	29083	broad.mit.edu	37	3	112710045	112710045	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr3:112710045C>T	ENST00000383677.3	+	1	214	c.199C>T	c.(199-201)Cac>Tac	p.H67Y	GTPBP8_ENST00000383678.2_Missense_Mutation_p.H67Y	NM_138485.1	NP_612494.1	Q8N3Z3	GTPB8_HUMAN	GTP-binding protein 8 (putative)	67					barrier septum formation		GTP binding			kidney(1)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	6						GCAAGACCTTCACCTGCGTAT	0.622000													16	84					0	0	1	0	0
GPR124	25960	broad.mit.edu	37	8	37691353	37691353	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr8:37691353G>C	ENST00000315215.7	+	10	1807	c.1444G>C	c.(1444-1446)Gag>Cag	p.E482Q	GPR124_ENST00000412232.2_Missense_Mutation_p.E482Q			Q96PE1	GP124_HUMAN	G protein-coupled receptor 124	482					central nervous system development|endothelial cell migration|neuropeptide signaling pathway|regulation of angiogenesis|regulation of chemotaxis|sprouting angiogenesis	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(16)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	37			BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)			CCAGATCAAAGAGGTGAGACT	0.532000													17	76					0	0	1	0	0
ZNF133	7692	broad.mit.edu	37	20	18297346	18297346	+	Silent	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr20:18297346C>G	ENST00000377671.3	+	7	2407	c.1848C>G	c.(1846-1848)ctC>ctG	p.L616L	ZNF133_ENST00000402618.2_Silent_p.L554L|ZNF133_ENST00000462170.1_3'UTR|ZNF133_ENST00000316358.4_Silent_p.L617L|ZNF133_ENST00000535822.1_Silent_p.L522L|ZNF133_ENST00000396026.3_Silent_p.L620L|ZNF133_ENST00000401790.1_Silent_p.L617L|ZNF133_ENST00000538547.1_Silent_p.L522L	NM_001083330.1|NM_003434.4	NP_001076799.1|NP_003425.2	P52736	ZN133_HUMAN	zinc finger protein 133	617						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	26						GCTTCAGCCTCAAGTCTCACC	0.567000													5	63					0	0	1	0	0
TRPC4	7223	broad.mit.edu	37	13	38237809	38237809	+	Nonsense_Mutation	SNP	C	C	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr13:38237809C>A	ENST00000379705.3	-	6	2289	c.1432G>T	c.(1432-1434)Gag>Tag	p.E478*	TRPC4_ENST00000379681.3_Nonsense_Mutation_p.E478*|TRPC4_ENST00000494529.1_5'UTR|TRPC4_ENST00000426868.2_Intron|TRPC4_ENST00000447043.1_Nonsense_Mutation_p.E478*|TRPC4_ENST00000355779.2_Nonsense_Mutation_p.E478*|TRPC4_ENST00000379679.1_Nonsense_Mutation_p.E305*|TRPC4_ENST00000358477.2_Nonsense_Mutation_p.E478*|TRPC4_ENST00000379673.2_Nonsense_Mutation_p.E478*|TRPC4_ENST00000338947.5_Nonsense_Mutation_p.E305*			Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel, subfamily C, member 4	478					axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			NS(2)|breast(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(26)|lung(30)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	83				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		AATAAAGCCTCTGCCACCAGA	0.443000													4	46					1	1	1	1	0
HSPD1	3329	broad.mit.edu	37	2	198352695	198352695	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr2:198352695C>T	ENST00000388968.3	-	11	1723	c.1456G>A	c.(1456-1458)Gaa>Aaa	p.E486K	HSPD1_ENST00000345042.2_Missense_Mutation_p.E486K	NM_002156.4	NP_002147.2	P10809	CH60_HUMAN	heat shock 60kDa protein 1 (chaperonin)	486					'de novo' protein folding|activation of caspase activity|B cell cytokine production|B cell proliferation|chaperone-mediated protein complex assembly|interspecies interaction between organisms|isotype switching to IgG isotypes|MyD88-dependent toll-like receptor signaling pathway|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of interferon-alpha production|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of macrophage activation|positive regulation of T cell activation|positive regulation of T cell mediated immune response to tumor cell|protein maturation|protein refolding|protein stabilization|response to unfolded protein|T cell activation	cell surface|coated pit|coated vesicle|cytosol|early endosome|extracellular space|lipopolysaccharide receptor complex|mitochondrial inner membrane|mitochondrial matrix|stored secretory granule	ATP binding|ATPase activity|cell surface binding|chaperone binding|DNA replication origin binding|lipopolysaccharide binding|p53 binding|single-stranded DNA binding			NS(1)|breast(3)|endometrium(2)|large_intestine(3)|lung(7)|skin(1)	17			Epithelial(96;0.225)			AAAGATCCTTCAACACCTGCA	0.328000													9	13					0	0	1	0	0
SPCS3	60559	broad.mit.edu	37	4	177241299	177241299	+	Silent	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr4:177241299C>T	ENST00000503362.1	+	1	185	c.72C>T	c.(70-72)ttC>ttT	p.F24F	RP11-87F15.2_ENST00000512634.1_RNA	NM_021928.3	NP_068747.1	P61009	SPCS3_HUMAN	signal peptidase complex subunit 3 homolog (S. cerevisiae)	24					energy reserve metabolic process|regulation of insulin secretion|signal peptide processing	integral to membrane|microsome|signal peptidase complex	peptidase activity			ovary(2)	2		Breast(14;0.0011)|Prostate(90;0.0129)|Melanoma(52;0.0133)|Renal(120;0.0376)|all_hematologic(60;0.124)		all cancers(43;2.43e-19)|Epithelial(43;1.84e-16)|OV - Ovarian serous cystadenocarcinoma(60;4.51e-09)|GBM - Glioblastoma multiforme(59;0.000142)|STAD - Stomach adenocarcinoma(60;0.00279)|LUSC - Lung squamous cell carcinoma(193;0.0319)		CGCTCACCTTCGGCTGCTTCA	0.657000													24	74					0	0	1	0	0
XRN1	54464	broad.mit.edu	37	3	142151666	142151666	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr3:142151666C>T	ENST00000264951.4	-	2	262	c.145G>A	c.(145-147)Gat>Aat	p.D49N	XRN1_ENST00000392981.2_Missense_Mutation_p.D49N|XRN1_ENST00000544157.1_5'UTR|XRN1_ENST00000463916.1_Missense_Mutation_p.D49N	NM_019001.3	NP_061874.3	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1	49					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			NS(1)|breast(3)|endometrium(6)|kidney(12)|large_intestine(11)|liver(1)|lung(17)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	61						TGAACATCATCATCATTAGGA	0.333000													6	43					0	0	1	0	0
NEK5	341676	broad.mit.edu	37	13	52676070	52676070	+	Splice_Site	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr13:52676070C>G	ENST00000355568.4	-	11	1030	c.892_splice	c.e11+1	p.Q297_splice		NM_199289.1	NP_954983.1	Q6P3R8	NEK5_HUMAN	NIMA-related kinase 5	297							ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(8)|lung(11)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	39		Breast(56;0.00173)|Lung NSC(96;0.0168)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;3.7e-08)		CACACTTACTCTGGACCACCT	0.428000													13	39					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128475487	128475487	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr7:128475487G>A	ENST00000325888.8	+	2	721	c.460G>A	c.(460-462)Gag>Aag	p.E154K	FLNC_ENST00000346177.6_Missense_Mutation_p.E154K	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	154	Actin-binding.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						TGAAGATGATGAGGATGCCCG	0.587000													36	90					0	0	1	0	0
JAG1	182	broad.mit.edu	37	20	10622175	10622175	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr20:10622175G>C	ENST00000254958.5	-	23	3364	c.2849C>G	c.(2848-2850)tCt>tGt	p.S950C	JAG1_ENST00000423891.2_Missense_Mutation_p.S791C	NM_000214.2	NP_000205.1	P78504	JAG1_HUMAN	jagged 1	950					angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(14)|ovary(2)|pancreas(1)|urinary_tract(1)	44						ATAGGAGTCAGAGGTGCACTT	0.488000									Alagille Syndrome				30	95					0	0	1	0	0
SBF2	81846	broad.mit.edu	37	11	9871600	9871600	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr11:9871600G>C	ENST00000256190.8	-	22	2913	c.2776C>G	c.(2776-2778)Ctc>Gtc	p.L926V	RP11-1H15.2_ENST00000533659.1_RNA	NM_030962.3	NP_112224.1	Q86WG5	MTMRD_HUMAN	SET binding factor 2	926	GRAM.				myelination	cytoplasm|membrane	phosphatase activity|protein binding			breast(4)|endometrium(8)|kidney(2)|large_intestine(8)|lung(16)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48				all cancers(16;2.88e-11)|Epithelial(150;3.61e-10)|BRCA - Breast invasive adenocarcinoma(625;0.00887)		CCTCTGAAGAGAATTCTGTAT	0.507000													26	83					0	0	1	0	0
OPRM1	4988	broad.mit.edu	37	6	154412513	154412513	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr6:154412513C>T	ENST00000414028.2	+	3	1120	c.1070C>T	c.(1069-1071)tCt>tTt	p.S357F	OPRM1_ENST00000452687.2_Missense_Mutation_p.S357F|OPRM1_ENST00000428397.2_Missense_Mutation_p.S357F|OPRM1_ENST00000518759.1_Missense_Mutation_p.S276F|OPRM1_ENST00000330432.7_Missense_Mutation_p.S357F|OPRM1_ENST00000524163.1_Missense_Mutation_p.S357F|OPRM1_ENST00000229768.5_Missense_Mutation_p.S357F|OPRM1_ENST00000522236.1_Missense_Mutation_p.S257F|OPRM1_ENST00000434900.2_Missense_Mutation_p.S450F|OPRM1_ENST00000522555.1_Missense_Mutation_p.S257F|OPRM1_ENST00000419506.2_Missense_Mutation_p.S357F|OPRM1_ENST00000435918.2_Missense_Mutation_p.S357F|OPRM1_ENST00000520708.1_Missense_Mutation_p.S257F|OPRM1_ENST00000360422.4_Missense_Mutation_p.S357F|OPRM1_ENST00000337049.4_Missense_Mutation_p.S357F	NM_001145284.2	NP_001138756.1	P35372	OPRM_HUMAN	opioid receptor, mu 1	357					behavior|negative regulation of cell proliferation|sensory perception	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	mu-opioid receptor activity|protein binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(15)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	33		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;9.26e-11)|BRCA - Breast invasive adenocarcinoma(81;0.0154)	Alfentanil(DB00802)|Anileridine(DB00913)|Buprenorphine(DB00921)|Butorphanol(DB00611)|Codeine(DB00318)|Dezocine(DB01209)|Diphenoxylate(DB01081)|Fentanyl(DB00813)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Levallorphan(DB00504)|Levomethadyl Acetate(DB01227)|Levorphanol(DB00854)|Loperamide(DB00836)|Methadone(DB00333)|Methadyl Acetate(DB01433)|Morphine(DB00295)|Nalbuphine(DB00844)|Naloxone(DB01183)|Naltrexone(DB00704)|Oxycodone(DB00497)|Oxymorphone(DB01192)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Remifentanil(DB00899)|Sufentanil(DB00708)|Tramadol(DB00193)	ATCCCAACCTCTTCCAACATT	0.453000													14	62					0	0	1	0	0
GRK7	131890	broad.mit.edu	37	3	141535592	141535592	+	Silent	SNP	T	T	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr3:141535592T>C	ENST00000264952.2	+	4	1499	c.1362T>C	c.(1360-1362)ttT>ttC	p.F454F		NM_139209.2	NP_631948.1	Q8WTQ7	GRK7_HUMAN	G protein-coupled receptor kinase 7	454	Protein kinase.				visual perception	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(14)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	26						ATCATTTCTTTAAAACGATCA	0.423000													25	106					0	0	1	0	0
PPP1R9A	55607	broad.mit.edu	37	7	94540770	94540770	+	Missense_Mutation	SNP	G	G	A	rs73423007	byFrequency	TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr7:94540770G>A	ENST00000289495.5	+	1	1561	c.1345G>A	c.(1345-1347)Gaa>Aaa	p.E449K	PPP1R9A_ENST00000433360.1_Missense_Mutation_p.E449K|PPP1R9A_ENST00000456331.2_Missense_Mutation_p.E449K|PPP1R9A_ENST00000340694.4_Missense_Mutation_p.E449K|PPP1R9A_ENST00000433881.1_Missense_Mutation_p.E449K|PPP1R9A_ENST00000424654.1_Missense_Mutation_p.E449K	NM_001166161.1	NP_001159633.1	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory subunit 9A	449	Interacts with protein phosphatase 1 (By similarity).|Poly-Glu.					cell junction|synapse|synaptosome	actin binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(11)|liver(2)|lung(22)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(8)|urinary_tract(5)	71	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			GCCAGAAGAAGAAGAAATCCC	0.378000										HNSCC(28;0.073)			8	34					0	0	1	0	0
FAM167B	84734	broad.mit.edu	37	1	32713068	32713068	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr1:32713068G>A	ENST00000373582.3	+	1	235	c.46G>A	c.(46-48)Gag>Aag	p.E16K		NM_032648.2	NP_116037.2	Q9BTA0	F167B_HUMAN	family with sequence similarity 167, member B	16										endometrium(1)|large_intestine(1)|lung(1)|ovary(2)	5						TGAAGAGGACGAGGAGGATGA	0.597000													21	93					0	0	1	0	0
GPR156	165829	broad.mit.edu	37	3	119892255	119892255	+	Silent	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr3:119892255G>A	ENST00000464295.1	-	9	1441	c.996C>T	c.(994-996)ttC>ttT	p.F332F	GPR156_ENST00000461057.1_Silent_p.F328F|GPR156_ENST00000315843.3_Silent_p.F332F			Q8NFN8	GP156_HUMAN	G protein-coupled receptor 156	332						integral to membrane|plasma membrane	G-protein coupled receptor activity|GABA-B receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(11)|lung(12)|ovary(1)|prostate(1)|skin(1)	32				GBM - Glioblastoma multiforme(114;0.19)		TGGGAGTGCTGAAATATTTGG	0.433000													22	112					0	0	1	0	0
TRPM5	29850	broad.mit.edu	37	11	2444157	2444157	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr11:2444157C>T	ENST00000452833.1	-	1	118	c.110G>A	c.(109-111)cGa>cAa	p.R37Q	TRPM5_ENST00000528453.1_Missense_Mutation_p.R37Q|TRPM5_ENST00000155858.6_Missense_Mutation_p.R37Q|TRPM5_ENST00000533060.1_Missense_Mutation_p.R37Q			Q9NZQ8	TRPM5_HUMAN	transient receptor potential cation channel, subfamily M, member 5	37						integral to membrane|plasma membrane	receptor activity|voltage-gated ion channel activity	p.R37P(1)		breast(1)|central_nervous_system(1)|endometrium(4)|liver(1)|lung(8)|ovary(2)|prostate(2)|skin(2)|urinary_tract(2)	23		Medulloblastoma(188;0.0049)|Breast(177;0.00586)|all_epithelial(84;0.0075)|Ovarian(85;0.0256)|all_neural(188;0.0311)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|LUSC - Lung squamous cell carcinoma(625;0.191)		TACCTTGCCTCGCTTCTTCCC	0.657000													13	26					0	0	1	0	0
TRIM39-RPP21	202658	broad.mit.edu	37	6	30313141	30313141	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr6:30313141G>A	ENST00000513556.1	+	7	907	c.907G>A	c.(907-909)Gag>Aag	p.E303K	RPP21_ENST00000466327.1_3'UTR|RPP21_ENST00000442966.2_Missense_Mutation_p.E42K|RPP21_ENST00000436442.2_Missense_Mutation_p.E42K|RPP21_ENST00000428040.2_Missense_Mutation_p.E65K|RPP21_ENST00000433076.2_Missense_Mutation_p.E42K	NM_001199119.1	NP_001186048.1	A6ZJ12	A6ZJ12_HUMAN		303						intracellular	zinc ion binding										CTGCTACACTGAGAGGACCAT	0.706000													10	35					0	0	1	0	0
SI	6476	broad.mit.edu	37	3	164739023	164739023	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr3:164739023C>T	ENST00000264382.3	-	27	3310	c.3248G>A	c.(3247-3249)aGa>aAa	p.R1083K		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	1083	Sucrase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TTACATGACTCTTCCACTGCT	0.348000										HNSCC(35;0.089)			24	83					0	0	1	0	0
AR	367	broad.mit.edu	37	X	66766006	66766006	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chrX:66766006G>A	ENST00000374690.3	+	1	1542	c.1018G>A	c.(1018-1020)Gaa>Aaa	p.E340K	AR_ENST00000504326.1_Missense_Mutation_p.E340K|AR_ENST00000396044.3_Missense_Mutation_p.E340K|AR_ENST00000513847.1_3'UTR	NM_000044.3	NP_000035.2	P10275	ANDR_HUMAN	androgen receptor	338	Modulating.		P -> L (in prostate cancer).		cell death|cell growth|cell proliferation|cell-cell signaling|negative regulation of apoptosis|negative regulation of integrin biosynthetic process|positive regulation of cell proliferation|positive regulation of integrin biosynthetic process|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|regulation of establishment of protein localization in plasma membrane|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transport	cytoplasm|nuclear chromatin|nucleoplasm	androgen binding|androgen receptor activity|beta-catenin binding|enzyme binding|ligand-regulated transcription factor activity|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(12)|lung(20)|ovary(3)|prostate(11)|stomach(2)|upper_aerodigestive_tract(3)	67	all_cancers(1;0.173)|Prostate(1;2.27e-16)|all_epithelial(1;0.102)	all_lung(315;1.3e-11)			Bicalutamide(DB01128)|Cyproterone(DB04839)|Dromostanolone(DB00858)|Finasteride(DB01216)|Fluoxymesterone(DB01185)|Flutamide(DB00499)|Nandrolone(DB00984)|Nilutamide(DB00665)|Oxandrolone(DB00621)|Testosterone(DB00624)	CGGGACACTTGAACTGCCGTC	0.592000									Androgen Insensitivity Syndrome				18	22					0	0	1	0	0
SPATA33	124045	broad.mit.edu	37	16	89724669	89724669	+	Missense_Mutation	SNP	G	G	C	rs138527131	byFrequency	TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr16:89724669G>C	ENST00000301031.4	+	2	48	c.48G>C	c.(46-48)aaG>aaC	p.K16N	SPATA33_ENST00000568929.1_5'UTR|SPATA33_ENST00000579310.1_Missense_Mutation_p.K17N	NM_001271908.1|NM_153025.1	NP_001258837.1|NP_694570.1			spermatogenesis associated 33																		AGGAGCAAAAGAAGGGATCCA	0.532000													19	68					0	0	1	0	0
CD207	50489	broad.mit.edu	37	2	71062641	71062641	+	Silent	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr2:71062641G>A	ENST00000410009.3	-	2	216	c.171C>T	c.(169-171)gtC>gtT	p.V57V		NM_015717.3	NP_056532.3	Q9UJ71	CLC4K_HUMAN	CD207 molecule, langerin	57					defense response to virus	endocytic vesicle|integral to membrane	mannose binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(13)|ovary(1)|stomach(1)	20						CCTGCAGCAGGACGGAGGCGA	0.607000													8	28					0	0	1	0	0
LMO3	55885	broad.mit.edu	37	12	16713349	16713349	+	Missense_Mutation	SNP	C	C	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr12:16713349C>A	ENST00000320122.6	-	3	852	c.330G>T	c.(328-330)caG>caT	p.Q110H	LMO3_ENST00000534946.1_Missense_Mutation_p.Q110H|LMO3_ENST00000540848.1_Missense_Mutation_p.Q110H|LMO3_ENST00000447609.1_Missense_Mutation_p.Q110H|LMO3_ENST00000441439.2_Missense_Mutation_p.Q110H|LMO3_ENST00000354662.1_Missense_Mutation_p.Q110H|LMO3_ENST00000261169.6_Missense_Mutation_p.Q121H|LMO3_ENST00000541846.1_Missense_Mutation_p.Q110H|LMO3_ENST00000535535.1_Missense_Mutation_p.Q110H|LMO3_ENST00000541295.1_Missense_Mutation_p.Q128H|LMO3_ENST00000540445.1_Missense_Mutation_p.Q132H|LMO3_ENST00000537304.1_Missense_Mutation_p.Q110H	NM_001243611.1	NP_001230540.1	Q8TAP4	LMO3_HUMAN	LIM domain only 3 (rhombotin-like 2)	110	LIM zinc-binding 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent		zinc ion binding			endometrium(2)|large_intestine(2)|skin(1)	5		Hepatocellular(102;0.244)				CTGCTTACCTCTGATTACAAA	0.418000													4	89					4.096e-09	4.34589e-09	1	1	0
CXXC1	30827	broad.mit.edu	37	18	47811132	47811132	+	Silent	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr18:47811132C>T	ENST00000285106.6	-	8	1704	c.990G>A	c.(988-990)gtG>gtA	p.V330V	CXXC1_ENST00000589940.1_Silent_p.V330V|CXXC1_ENST00000412036.2_Silent_p.V330V	NM_001101654.1|NM_014593.3	NP_001095124.1|NP_055408.2	Q9P0U4	CXXC1_HUMAN	CXXC finger protein 1	330	Arg/Lys-rich (basic).				histone H3-K4 methylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck|Set1C/COMPASS complex	protein binding|unmethylated CpG binding|zinc ion binding			autonomic_ganglia(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	24						cccGACGCTTCACATGCTTCA	0.582000													9	22					0	0	1	0	0
BTAF1	9044	broad.mit.edu	37	10	93773781	93773781	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr10:93773781C>T	ENST00000265990.6	+	32	4887	c.4579C>T	c.(4579-4581)Ctc>Ttc	p.L1527F	BTAF1_ENST00000544642.1_Missense_Mutation_p.L355F	NM_003972.2	NP_003963.1	O14981	BTAF1_HUMAN	BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa	1527					negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(2)|urinary_tract(6)	59		Colorectal(252;0.0846)				TCTTAGTCCTCTCCAGGTTAG	0.363000													18	102					0	0	1	0	0
CDYL	9425	broad.mit.edu	37	6	4891958	4891958	+	Silent	SNP	T	T	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr6:4891958T>C	ENST00000328908.5	+	4	329	c.198T>C	c.(196-198)atT>atC	p.I66I	CDYL_ENST00000343762.5_5'UTR|CDYL_ENST00000449732.2_5'UTR|CDYL_ENST00000472453.1_Intron|CDYL_ENST00000397588.3_Silent_p.I12I			Q9Y232	CDYL1_HUMAN	chromodomain protein, Y-like	66	Chromo.				regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	histone acetyltransferase activity			breast(2)|kidney(2)|large_intestine(9)|lung(13)|skin(1)|stomach(2)|urinary_tract(1)	30	Ovarian(93;0.11)	all_hematologic(90;0.0901)|Lung NSC(90;0.244)		OV - Ovarian serous cystadenocarcinoma(45;0.182)		TTGAAAGGATTGTTGACAAAA	0.378000													24	38					0	0	1	0	0
BTBD8	284697	broad.mit.edu	37	1	92612785	92612785	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr1:92612785C>T	ENST00000342818.3	+	8	1215	c.979C>T	c.(979-981)Cat>Tat	p.H327Y	BTBD8_ENST00000540648.1_3'UTR	NM_183242.3	NP_899065.2	Q5XKL5	BTBD8_HUMAN	BTB (POZ) domain containing 8	327						nucleus				breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(8)|ovary(1)	16		all_lung(203;0.0484)|Lung NSC(277;0.126)|Glioma(108;0.222)		all cancers(265;0.0153)|Epithelial(280;0.0982)		GATTATTGCTCATTCAGTTGG	0.338000													15	60					0	0	1	0	0
KBTBD7	84078	broad.mit.edu	37	13	41767771	41767771	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr13:41767771G>A	ENST00000379483.3	-	1	931	c.623C>T	c.(622-624)tCa>tTa	p.S208L		NM_032138.4	NP_115514.2	Q8WVZ9	KBTB7_HUMAN	kelch repeat and BTB (POZ) domain containing 7	208							protein binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(8)|ovary(4)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	24		Lung NSC(96;0.000105)|Breast(139;0.00715)|Prostate(109;0.0233)|Lung SC(185;0.0367)		all cancers(112;6.21e-09)|Epithelial(112;6.99e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000196)|GBM - Glioblastoma multiforme(144;0.000857)|BRCA - Breast invasive adenocarcinoma(63;0.0669)		CTCCCGAATTGAACCCATTCG	0.542000													26	88					0	0	1	0	0
RPGRIP1L	23322	broad.mit.edu	37	16	53726170	53726170	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr16:53726170C>T	ENST00000262135.4	-	4	430	c.337G>A	c.(337-339)Gag>Aag	p.E113K	RPGRIP1L_ENST00000379925.3_Missense_Mutation_p.E113K|RPGRIP1L_ENST00000564374.1_Missense_Mutation_p.E113K|RPGRIP1L_ENST00000563746.1_Missense_Mutation_p.E113K	NM_001127897.1	NP_001121369.1	Q68CZ1	FTM_HUMAN	RPGRIP1-like	113					negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			endometrium(6)|kidney(3)|large_intestine(9)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(2)	46		all_cancers(37;0.0973)				TGCAGCTGCTCAATCATTTCT	0.448000													47	163					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8460493	8460493	+	Nonsense_Mutation	SNP	C	C	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr9:8460493C>A	ENST00000381196.4	-	30	4336	c.3793G>T	c.(3793-3795)Gaa>Taa	p.E1265*	PTPRD_ENST00000360074.4_Nonsense_Mutation_p.E1252*|PTPRD_ENST00000540109.1_Nonsense_Mutation_p.E1265*|PTPRD_ENST00000537002.1_Nonsense_Mutation_p.E851*|PTPRD_ENST00000358503.5_Nonsense_Mutation_p.E1243*|PTPRD_ENST00000486161.1_Nonsense_Mutation_p.E854*|PTPRD_ENST00000356435.5_Nonsense_Mutation_p.E1265*|PTPRD_ENST00000355233.5_Nonsense_Mutation_p.E854*|PTPRD_ENST00000397606.3_Nonsense_Mutation_p.E844*|PTPRD_ENST00000397611.3_Nonsense_Mutation_p.E851*|PTPRD_ENST00000397617.3_Nonsense_Mutation_p.E844*	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1265					transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		ATCAAGCCTTCTTCTTCATCC	0.453000										TSP Lung(15;0.13)			26	78					1.42536e-11	1.53264e-11	1	1	0
DPYSL4	10570	broad.mit.edu	37	10	134006300	134006300	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr10:134006300C>G	ENST00000338492.4	+	3	431	c.267C>G	c.(265-267)ttC>ttG	p.F89L	DPYSL4_ENST00000493882.1_3'UTR|DPYSL4_ENST00000368627.1_Missense_Mutation_p.F12L|DPYSL4_ENST00000368629.1_Missense_Mutation_p.F12L	NM_006426.2	NP_006417.2	O14531	DPYL4_HUMAN	dihydropyrimidinase-like 4	89					axon guidance|pyrimidine base catabolic process	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			NS(1)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		all_cancers(35;4.33e-08)|all_epithelial(44;6.75e-06)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)|Colorectal(31;0.19)		OV - Ovarian serous cystadenocarcinoma(35;7.21e-05)|Epithelial(32;8.01e-05)|all cancers(32;9.29e-05)|BRCA - Breast invasive adenocarcinoma(275;0.206)		CTGACGACTTCTGTCAGGGCA	0.622000													20	54					0	0	1	0	0
DOCK8	81704	broad.mit.edu	37	9	304659	304659	+	Silent	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr9:304659G>A	ENST00000432829.2	+	5	595	c.279G>A	c.(277-279)caG>caA	p.Q93Q	DOCK8_ENST00000453981.1_Silent_p.Q161Q|DOCK8_ENST00000469391.1_Silent_p.Q93Q	NM_203447.3	NP_982272.2	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	161					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(5)|endometrium(2)|kidney(6)|large_intestine(13)|lung(22)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	65		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		TTCCGAAACAGACGTTTGAGT	0.443000													10	194					0	0	1	0	0
DEFB114	245928	broad.mit.edu	37	6	49928037	49928037	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr6:49928037C>G	ENST00000322066.3	-	2	177	c.178G>C	c.(178-180)Gag>Cag	p.E60Q		NM_001037499.1	NP_001032588.1	Q30KQ6	DB114_HUMAN	defensin, beta 114	60					defense response to bacterium	extracellular region				kidney(1)|large_intestine(1)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	8	Lung NSC(77;0.042)					TACAATTTCTCAGTGCAGCAA	0.378000													6	20					0	0	1	0	0
MYH8	4626	broad.mit.edu	37	17	10303815	10303815	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr17:10303815C>G	ENST00000403437.2	-	27	3721	c.3627G>C	c.(3625-3627)caG>caC	p.Q1209H	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000581304.1_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	1209					muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						AGTTGTCAATCTGCTCCCCAA	0.552000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				20	80					0	0	1	0	0
GRWD1	83743	broad.mit.edu	37	19	48950050	48950050	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr19:48950050C>G	ENST00000253237.5	+	3	651	c.418C>G	c.(418-420)Cag>Gag	p.Q140E		NM_031485.3	NP_113673.3	Q9BQ67	GRWD1_HUMAN	glutamate-rich WD repeat containing 1	140						nucleolus				endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|stomach(1)	19		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000206)|all cancers(93;0.000207)|Epithelial(262;0.0125)|GBM - Glioblastoma multiforme(486;0.0222)		GCGGAAACCTCAGCTGGAGCT	0.542000													28	43					0	0	1	0	0
TBC1D8B	54885	broad.mit.edu	37	X	106093309	106093309	+	Missense_Mutation	SNP	A	A	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chrX:106093309A>T	ENST00000357242.5	+	12	2066	c.1892A>T	c.(1891-1893)cAg>cTg	p.Q631L	TBC1D8B_ENST00000276175.3_Missense_Mutation_p.Q625L	NM_017752.2	NP_060222.2	Q0IIM8	TBC8B_HUMAN	TBC1 domain family, member 8B (with GRAM domain)	631	Rab-GAP TBC.					intracellular	calcium ion binding|Rab GTPase activator activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(6)|liver(4)|lung(15)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						CACCTTCCTCAGCTGACAGAA	0.378000													18	23					0	0	1	0	0
ZNF750	79755	broad.mit.edu	37	17	80789586	80789586	+	Nonsense_Mutation	SNP	C	C	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr17:80789586C>A	ENST00000269394.3	-	2	1578	c.745G>T	c.(745-747)Gag>Tag	p.E249*	TBCD_ENST00000539345.2_Intron|TBCD_ENST00000397466.2_Intron|TBCD_ENST00000355528.4_Intron|ZNF750_ENST00000572562.1_Intron	NM_024702.2	NP_078978.2	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	249						intracellular	zinc ion binding			NS(3)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|large_intestine(4)|lung(12)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	31	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)			AGCCCGTGCTCTGTGTAAAAG	0.567000													53	52					1.48341e-19	1.62121e-19	1	1	0
SIX5	147912	broad.mit.edu	37	19	46269022	46269022	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr19:46269022C>G	ENST00000317578.6	-	3	2338	c.1957G>C	c.(1957-1959)Gag>Cag	p.E653Q	AC074212.5_ENST00000559756.1_RNA|SIX5_ENST00000560168.1_3'UTR	NM_175875.4	NP_787071.2	Q8N196	SIX5_HUMAN	SIX homeobox 5	653						cytoplasm|nucleus	protein binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(2)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	8		Ovarian(192;0.0308)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00783)|GBM - Glioblastoma multiforme(486;0.0802)|Epithelial(262;0.235)		ATCAGCCCCTCTGGTGGGGGC	0.692000													7	81					0	0	1	0	0
KIAA0226	9711	broad.mit.edu	37	3	197427940	197427940	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr3:197427940C>G	ENST00000273582.5	-	7	1170	c.625G>C	c.(625-627)Gag>Cag	p.E209Q	KIAA0226_ENST00000389665.5_Missense_Mutation_p.E269Q|KIAA0226_ENST00000296343.5_Missense_Mutation_p.E269Q|KIAA0226_ENST00000449205.1_Missense_Mutation_p.E269Q	NM_001145642.2	NP_001139114.1	Q92622	RUBIC_HUMAN	KIAA0226	269	Ser-rich.				autophagy|endocytosis|negative regulation of autophagy|negative regulation of endocytosis	early endosome|late endosome|lysosome	protein binding			NS(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_cancers(143;8.26e-10)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;2.19e-23)|all cancers(36;1.39e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.21e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(93;0.0446)		GTTTGATCCTCTGCTGGTGAG	0.512000													4	123					0	0	1	0	0
MAGI2	9863	broad.mit.edu	37	7	77755125	77755125	+	Silent	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr7:77755125C>T	ENST00000354212.4	-	20	3706	c.3453G>A	c.(3451-3453)gaG>gaA	p.E1151E	MAGI2_ENST00000522391.1_Silent_p.E1151E|MAGI2_ENST00000419488.1_Silent_p.E1137E	NM_012301.3	NP_036433.2	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 2	1151	PDZ 6.					cell junction|synapse|synaptosome	phosphatase binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(37)|ovary(5)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(3)	84		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				TGGCTCCTTTCTCCATGTCCA	0.403000													12	39					0	0	1	0	0
CYFIP1	23191	broad.mit.edu	37	15	22929869	22929869	+	Silent	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr15:22929869G>A	ENST00000313077.7	+	6	668	c.543G>A	c.(541-543)gtG>gtA	p.V181V	CYFIP1_ENST00000560848.1_Silent_p.V181V	NM_014608.2	NP_055423.1	Q7L576	CYFP1_HUMAN	cytoplasmic FMR1 interacting protein 1	181					axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|liver(1)|lung(14)|ovary(4)|pancreas(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	40		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)		AGTGCAGTGTGAAGAACGACC	0.577000													10	55					0	0	1	0	0
ATAD2	29028	broad.mit.edu	37	8	124371872	124371872	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr8:124371872C>T	ENST00000287394.5	-	10	1318	c.1211G>A	c.(1210-1212)cGa>cAa	p.R404Q	ATAD2_ENST00000521903.1_5'UTR|ATAD2_ENST00000534257.1_5'UTR	NM_014109.3	NP_054828.2	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	404					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|lung(16)|ovary(3)|prostate(3)|skin(1)|urinary_tract(2)	48	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			AATTTTCATTCGATCTTTATA	0.353000													7	36					0	0	1	0	0
SERTAD2	9792	broad.mit.edu	37	2	64863799	64863799	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr2:64863799C>G	ENST00000313349.3	-	2	504	c.207G>C	c.(205-207)ttG>ttC	p.L69F	SERTAD2_ENST00000476805.1_5'UTR	NM_014755.2	NP_055570.1	Q14140	SRTD2_HUMAN	SERTA domain containing 2	69	SERTA.				negative regulation of cell growth|transcription, DNA-dependent	cytoplasm|nucleus				breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|skin(1)	12						GGATCCGCCTCAACATGTTGT	0.542000													18	86					0	0	1	0	0
DSN1	79980	broad.mit.edu	37	20	35381261	35381261	+	Missense_Mutation	SNP	C	C	T	rs143517734	by1000genomes	TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr20:35381261C>T	ENST00000426836.1	-	11	1373	c.1001G>A	c.(1000-1002)cGa>cAa	p.R334Q	DSN1_ENST00000448110.1_Missense_Mutation_p.R318Q|DSN1_ENST00000473615.1_5'UTR|DSN1_ENST00000373745.3_Missense_Mutation_p.R334Q|DSN1_ENST00000373740.3_Missense_Mutation_p.R262Q|DSN1_ENST00000373750.4_Missense_Mutation_p.R334Q|DSN1_ENST00000373734.4_Missense_Mutation_p.R227Q	NM_001145316.1	NP_001138788.1	Q9H410	DSN1_HUMAN	DSN1, MIS12 kinetochore complex component	334					cell division|chromosome segregation|mitotic prometaphase	cytosol|MIS12/MIND type complex|nucleus	protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	16		Myeloproliferative disorder(115;0.00874)				CAACAGTTTTCGAGCTGGTGA	0.408000													15	89					0	0	1	0	0
PDZD2	23037	broad.mit.edu	37	5	32089962	32089962	+	Silent	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr5:32089962C>T	ENST00000438447.1	+	20	6796	c.6408C>T	c.(6406-6408)gtC>gtT	p.V2136V	PDZD2_ENST00000282493.3_Silent_p.V2136V			O15018	PDZD2_HUMAN	PDZ domain containing 2	2136					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				NS(2)|breast(4)|central_nervous_system(5)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(31)|lung(58)|ovary(6)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	148						ATCGCCAGGTCGCAGAATCAT	0.542000													23	92					0	0	1	0	0
SLC25A44	9673	broad.mit.edu	37	1	156180047	156180047	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr1:156180047C>T	ENST00000359511.4	+	4	942	c.770C>T	c.(769-771)tCc>tTc	p.S257F	SLC25A44_ENST00000423538.2_Missense_Mutation_p.S234F|SLC25A44_ENST00000469537.1_3'UTR	NM_014655.2	NP_055470.1	Q96H78	S2544_HUMAN	solute carrier family 25, member 44	257					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			breast(3)|kidney(2)|large_intestine(2)|lung(1)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14	Hepatocellular(266;0.158)					GGCAAGAACTCCATCATCCTG	0.547000													36	62					0	0	1	0	0
PDZRN4	29951	broad.mit.edu	37	12	41903701	41903701	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr12:41903701G>A	ENST00000298919.7	+	5	797	c.409G>A	c.(409-411)Gac>Aac	p.D137N	PDZRN4_ENST00000402685.2_Missense_Mutation_p.D397N|PDZRN4_ENST00000539469.2_Missense_Mutation_p.D139N			Q6ZMN7	PZRN4_HUMAN	PDZ domain containing ring finger 4	397	Gly-rich.						ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	77	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				CAGAACAGAAGACTTTGAATA	0.373000													10	56					0	0	1	0	0
DPP10	57628	broad.mit.edu	37	2	116593750	116593750	+	Silent	SNP	T	T	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr2:116593750T>C	ENST00000410059.1	+	22	2448	c.1968T>C	c.(1966-1968)atT>atC	p.I656I	DPP10_ENST00000409163.1_Silent_p.I606I|DPP10_ENST00000310323.8_Silent_p.I649I|DPP10_ENST00000393147.2_Silent_p.I660I	NM_001178037.1|NM_020868.3	NP_001171508.1|NP_065919.2	Q8N608	DPP10_HUMAN	dipeptidyl-peptidase 10 (non-functional)	656					proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(24)|liver(2)|lung(48)|ovary(6)|prostate(1)|skin(5)|soft_tissue(1)	101						GTGGCTATATTGCATCAATGA	0.333000													10	27					0	0	1	0	0
EP300	2033	broad.mit.edu	37	22	41572777	41572777	+	Splice_Site	SNP	G	G	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr22:41572777G>C	ENST00000263253.7	+	31	6281	c.5061_splice	c.e31-1	p.D1688_splice	RP1-85F18.6_ENST00000415054.1_RNA|RP1-85F18.5_ENST00000420537.1_RNA	NM_001429.3	NP_001420.2	Q09472	EP300_HUMAN	E1A binding protein p300	1688	Binding region for E1A adenovirus.				apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			NS(2)|breast(11)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(31)|kidney(5)|large_intestine(31)|liver(2)|lung(33)|ovary(2)|pancreas(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(16)	171						TTTTCCCTAGGATTATGACTT	0.403000			"""T,  N, F, Mis, O"""	"""MLL, RUNXBP2"""	"""colorectal, breast, pancreatic, AML, ALL, DLBCL"""				Rubinstein-Taybi syndrome				32	100					0	0	1	0	0
CCDC89	220388	broad.mit.edu	37	11	85396555	85396555	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr11:85396555G>A	ENST00000316398.3	-	1	765	c.619C>T	c.(619-621)Cgc>Tgc	p.R207C		NM_152723.1	NP_689936.1	Q8N998	CCD89_HUMAN	coiled-coil domain containing 89	207						cytoplasm|nucleus				NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(6)|skin(1)	15		Acute lymphoblastic leukemia(157;4.88e-06)|all_hematologic(158;0.00572)				TCCTTCTCGCGCGCCTGTGCC	0.617000													23	119					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237774148	237774148	+	Silent	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr1:237774148C>T	ENST00000366574.2	+	36	5087	c.4770C>T	c.(4768-4770)ttC>ttT	p.F1590F	RYR2_ENST00000542537.1_Silent_p.F1574F|RYR2_ENST00000360064.6_Silent_p.F1588F	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	1590	4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ACGTGCAGTTCCTGTCACACG	0.557000													11	20					0	0	1	0	0
ZDBF2	57683	broad.mit.edu	37	2	207172263	207172263	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr2:207172263C>G	ENST00000374423.3	+	5	3397	c.3011C>G	c.(3010-3012)tCt>tGt	p.S1004C		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	1004							nucleic acid binding|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						AGTTTAGATTCTGGTGTCCCT	0.343000													12	57					0	0	1	0	0
EPAS1	2034	broad.mit.edu	37	2	46609636	46609636	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr2:46609636C>G	ENST00000263734.3	+	15	2870	c.2360C>G	c.(2359-2361)tCt>tGt	p.S787C		NM_001430.4	NP_001421.2	Q99814	EPAS1_HUMAN	endothelial PAS domain protein 1	787					angiogenesis|myoblast cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|response to hypoxia	transcription factor complex	histone acetyltransferase binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription coactivator activity|transcription factor binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(11)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	LUSC - Lung squamous cell carcinoma(58;0.151)			CAGCCTCCATCTGCCATCAGT	0.592000													5	141					0	0	1	0	0
CPSF2	53981	broad.mit.edu	37	14	92600486	92600486	+	Missense_Mutation	SNP	G	G	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr14:92600486G>T	ENST00000298875.4	+	4	566	c.281G>T	c.(280-282)gGa>gTa	p.G94V		NM_017437.2	NP_059133.1	Q9P2I0	CPSF2_HUMAN	cleavage and polyadenylation specific factor 2, 100kDa	94					histone mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	hydrolase activity|protein binding|RNA binding			breast(2)|cervix(1)|endometrium(3)|large_intestine(2)|lung(7)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	24		all_cancers(154;0.0766)		COAD - Colon adenocarcinoma(157;0.222)		TATAAAATGGGACAGATGTTC	0.383000													19	64					2.94398e-08	3.10711e-08	1	1	0
AC079210.1	0	broad.mit.edu	37	17	66539808	66539808	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr17:66539808C>G	ENST00000600820.1	+	1	440	c.67C>G	c.(67-69)Ctg>Gtg	p.L23V	PRKAR1A_ENST00000588188.2_Intron|FAM20A_ENST00000592554.1_Missense_Mutation_p.Q258H|FAM20A_ENST00000226094.5_5'UTR																							CATTGTGTCTCTGAAAGTCAA	0.537000													6	97					0	0	1	0	0
EIF3A	8661	broad.mit.edu	37	10	120797938	120797938	+	Silent	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr10:120797938C>T	ENST00000369144.3	-	20	3667	c.3540G>A	c.(3538-3540)gaG>gaA	p.E1180E	EIF3A_ENST00000541549.1_Silent_p.E1146E|EIF3A_ENST00000478852.1_Intron	NM_003750.2	NP_003741.1	Q14152	EIF3A_HUMAN	eukaryotic translation initiation factor 3, subunit A	1180	Asp-rich.				formation of translation initiation complex	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|structural molecule activity|translation initiation factor activity			endometrium(8)|kidney(4)|large_intestine(14)|lung(22)|prostate(1)|skin(4)|urinary_tract(3)	56		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0236)		CTTTTTCTTTCTCTCTCCATC	0.378000													26	120					0	0	1	0	0
HIVEP3	59269	broad.mit.edu	37	1	42041232	42041232	+	Silent	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr1:42041232G>A	ENST00000372584.1	-	4	6204	c.5190C>T	c.(5188-5190)atC>atT	p.I1730I	HIVEP3_ENST00000372583.1_Silent_p.I1730I|HIVEP3_ENST00000460604.1_5'UTR|HIVEP3_ENST00000429157.2_Silent_p.I1730I|HIVEP3_ENST00000247584.5_Silent_p.I1730I	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	1730					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				CGAAGATTTTGATCCTCGCCG	0.557000													55	303					0	0	1	0	0
PTGER4	5734	broad.mit.edu	37	5	40681938	40681938	+	Silent	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr5:40681938G>A	ENST00000302472.3	+	2	1867	c.843G>A	c.(841-843)gtG>gtA	p.V281V		NM_000958.2	NP_000949.1	P35408	PE2R4_HUMAN	prostaglandin E receptor 4 (subtype EP4)	281					G-protein signaling, coupled to cAMP nucleotide second messenger|immune response	integral to membrane|plasma membrane	prostaglandin E receptor activity			breast(1)|endometrium(3)|liver(1)|lung(13)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	23						CCCTGGTGGTGCTCATCTGCT	0.667000													4	73					0	0	1	0	0
CACNA1I	8911	broad.mit.edu	37	22	40078504	40078504	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr22:40078504G>A	ENST00000336649.4	+	38	5686	c.5686G>A	c.(5686-5688)Gag>Aag	p.E1896K	CACNA1I_ENST00000404898.1_Missense_Mutation_p.E1855K|CACNA1I_ENST00000402142.3_Missense_Mutation_p.E1890K|CACNA1I_ENST00000400164.3_Missense_Mutation_p.E1855K|CACNA1I_ENST00000401624.1_Missense_Mutation_p.E1890K|CACNA1I_ENST00000407673.1_Missense_Mutation_p.E1855K			Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type, alpha 1I subunit	1890					axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(2)|lung(27)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	CTTGCAGGGTGAGCTGGACCC	0.607000													14	82					0	0	1	0	0
ITSN2	50618	broad.mit.edu	37	2	24431971	24431971	+	Silent	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr2:24431971C>T	ENST00000355123.4	-	36	5036	c.4593G>A	c.(4591-4593)gaG>gaA	p.E1531E	ITSN2_ENST00000361999.3_Silent_p.E1504E	NM_006277.2	NP_006268.2	Q9NZM3	ITSN2_HUMAN	intersectin 2	1531	PH.				endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(8)|large_intestine(11)|liver(3)|lung(28)|ovary(2)|stomach(1)	61	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGACTGACCTCTCATTAATGT	0.547000													7	36					0	0	1	0	0
ITGAL	3683	broad.mit.edu	37	16	30495277	30495277	+	Silent	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr16:30495277C>T	ENST00000356798.6	+	8	1032	c.852C>T	c.(850-852)atC>atT	p.I284I	ITGAL_ENST00000454514.2_3'UTR|ITGAL_ENST00000433423.2_Intron|ITGAL_ENST00000358164.5_Silent_p.I201I|RP11-297C4.2_ENST00000569459.1_RNA	NM_002209.2	NP_002200.2	P20701	ITAL_HUMAN	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	284	VWFA.				blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(10)|kidney(4)|large_intestine(12)|lung(32)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	76					Efalizumab(DB00095)	GCTACATCATCGGGGTAGGGC	0.547000													46	178					0	0	1	0	0
MYO15A	51168	broad.mit.edu	37	17	18023111	18023111	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr17:18023111G>A	ENST00000205890.5	+	2	1335	c.997G>A	c.(997-999)Gag>Aag	p.E333K		NM_016239.3	NP_057323.3	Q9UKN7	MYO15_HUMAN	myosin XVA	333	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			breast(5)|central_nervous_system(2)|endometrium(17)|kidney(3)|large_intestine(16)|lung(27)|ovary(3)|pancreas(1)|prostate(6)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	99	all_neural(463;0.228)					CGATGGGTACGAGGGCGAGGC	0.602000													38	119					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13758984	13758984	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr5:13758984C>G	ENST00000265104.4	-	61	10494	c.10390G>C	c.(10390-10392)Gag>Cag	p.E3464Q		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3464	Stalk (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TGTTCATACTCAGCCTGCACC	0.537000									Kartagener syndrome				35	114					0	0	1	0	0
COPG1	22820	broad.mit.edu	37	3	128979521	128979521	+	Silent	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr3:128979521C>G	ENST00000314797.6	+	12	1103	c.999C>G	c.(997-999)gtC>gtG	p.V333V		NM_016128.3	NP_057212.1	Q9Y678	COPG_HUMAN	coatomer protein complex, subunit gamma 1	333					COPI coating of Golgi vesicle|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity										AGAACCTGGTCACAGATTCAA	0.552000													6	94					0	0	1	0	0
SLX4	84464	broad.mit.edu	37	16	3632371	3632371	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr16:3632371C>T	ENST00000294008.3	-	15	6117	c.5477G>A	c.(5476-5478)cGg>cAg	p.R1826Q	RP11-461A8.1_ENST00000573982.1_lincRNA	NM_032444.2	NP_115820.2	Q8IY92	SLX4_HUMAN	SLX4 structure-specific endonuclease subunit	1826	Interaction with PLK1 and TERF2-TERF2IP.|Interaction with SLX1.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding			breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	76						CTTCTTGCCCCGAGGCTGCCG	0.667000								Direct reversal of damage					25	88					0	0	1	0	0
CNTNAP2	26047	broad.mit.edu	37	7	147869528	147869528	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr7:147869528G>A	ENST00000361727.3	+	18	3484	c.2968G>A	c.(2968-2970)Gat>Aat	p.D990N	CNTNAP2_ENST00000538075.1_Missense_Mutation_p.D49N	NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	990	EGF-like 2.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding	p.D990N(1)		NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			TTACTCCTGCGATTGCTCTAA	0.453000										HNSCC(39;0.1)			20	87					0	0	1	0	0
REV3L	5980	broad.mit.edu	37	6	111695940	111695940	+	Missense_Mutation	SNP	C	C	G	rs35802572		TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr6:111695940C>G	ENST00000435970.1	-	15	4200	c.3384G>C	c.(3382-3384)aaG>aaC	p.K1128N	REV3L_ENST00000358835.3_Missense_Mutation_p.K1206N|REV3L_ENST00000368805.1_Missense_Mutation_p.K1206N|REV3L_ENST00000368802.3_Missense_Mutation_p.K1206N			O60673	DPOLZ_HUMAN	REV3-like, polymerase (DNA directed), zeta, catalytic subunit	1206					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			NS(2)|breast(1)|endometrium(6)|kidney(7)|large_intestine(30)|lung(25)|ovary(3)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	88		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		CTCTTGGTTTCTTTTTTCCAT	0.323000								DNA polymerases (catalytic subunits)					6	35					0	0	1	0	0
ZBTB21	49854	broad.mit.edu	37	21	43411138	43411138	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr21:43411138C>T	ENST00000310826.5	-	3	3250	c.3067G>A	c.(3067-3069)Gaa>Aaa	p.E1023K	ZBTB21_ENST00000398499.1_Missense_Mutation_p.E1023K|ZBTB21_ENST00000398511.3_Missense_Mutation_p.E1023K|ZBTB21_ENST00000398505.3_Missense_Mutation_p.E822K	NM_001098402.1	NP_001091872.1			zinc finger and BTB domain containing 21																		GTGTCTGATTCTTGGGGCACA	0.498000													16	58					0	0	1	0	0
SRGAP2-AS1	100873165	broad.mit.edu	37	1	121115981	121115981	+	RNA	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr1:121115981C>T	ENST00000437515.1	-	0	329																											CCACGGCCAACGTTCGCATTG	0.527000													3	11					0	0	1	0	0
ALDH1L1	10840	broad.mit.edu	37	3	125865695	125865695	+	Silent	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr3:125865695C>T	ENST00000393434.2	-	9	1408	c.1059G>A	c.(1057-1059)gcG>gcA	p.A353A	ALDH1L1_ENST00000393431.2_Silent_p.A353A|ALDH1L1_ENST00000273450.3_Silent_p.A363A|ALDH1L1_ENST00000472186.1_Silent_p.A353A|ALDH1L1_ENST00000452905.2_Silent_p.A252A	NM_012190.3	NP_036322.2	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	353	Acyl carrier.				10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(5)|large_intestine(10)|lung(22)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	52				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	CGTCCACAGACGCGGCCCCTG	0.542000													5	55					0	0	1	0	0
NOL4	8715	broad.mit.edu	37	18	31599388	31599388	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr18:31599388G>A	ENST00000261592.5	-	6	1247	c.950C>T	c.(949-951)tCg>tTg	p.S317L	NOL4_ENST00000269185.4_Missense_Mutation_p.S203L|NOL4_ENST00000538587.1_Missense_Mutation_p.S243L|NOL4_ENST00000535384.1_Missense_Mutation_p.S32L|NOL4_ENST00000535475.1_Missense_Mutation_p.S162L|NOL4_ENST00000589544.1_Missense_Mutation_p.S317L	NM_001198546.1|NM_003787.4	NP_001185475.1|NP_003778.2	O94818	NOL4_HUMAN	nucleolar protein 4	317						nucleolus	RNA binding			NS(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(7)|lung(20)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	51						TCTGTATTCCGAAGTTAGCTG	0.458000													5	55					0	0	1	0	0
HRAS	3265	broad.mit.edu	37	11	533550	533550	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr11:533550C>T	ENST00000417302.1	-	4	540	c.353G>A	c.(352-354)tGt>tAt	p.C118Y	HRAS_ENST00000397596.2_Missense_Mutation_p.C118Y|HRAS_ENST00000311189.7_Missense_Mutation_p.C118Y|HRAS_ENST00000397594.1_Missense_Mutation_p.C118Y|HRAS_ENST00000451590.1_Missense_Mutation_p.C118Y	NM_176795.3	NP_789765.1	P01112	RASH_HUMAN	Harvey rat sarcoma viral oncogene homolog	118					activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding			adrenal_gland(1)|bone(3)|breast(7)|cervix(23)|endometrium(4)|haematopoietic_and_lymphoid_tissue(12)|kidney(1)|large_intestine(2)|liver(1)|lung(16)|oesophagus(2)|penis(2)|pituitary(10)|prostate(31)|salivary_gland(24)|skin(184)|soft_tissue(38)|stomach(14)|testis(5)|thymus(1)|thyroid(173)|upper_aerodigestive_tract(122)|urinary_tract(225)	901		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	AGCCAGGTCACACTTGTTCCC	0.632000		6	Mis		"""infrequent sarcomas, rare other types"""	"""rhadomyosarcoma, ganglioneuroblastoma, bladder"""			Costello syndrome	HNSCC(11;0.0054)			45	103					0	0	1	0	0
SAMD8	142891	broad.mit.edu	37	10	76928320	76928320	+	Silent	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr10:76928320C>T	ENST00000542569.1	+	4	799	c.696C>T	c.(694-696)ctC>ctT	p.L232L	SAMD8_ENST00000372690.3_Silent_p.L295L|SAMD8_ENST00000372687.3_Silent_p.L232L	NM_001174156.1|NM_144660.2	NP_001167627.1|NP_653261.1	Q96LT4	SAMD8_HUMAN	sterile alpha motif domain containing 8	232					sphingomyelin biosynthetic process	integral to membrane				NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|prostate(1)	12	all_cancers(46;0.0207)|all_epithelial(25;0.00126)|Prostate(51;0.0112)|Ovarian(15;0.0348)					TGCGAAGGCTCTGTAGTCTGA	0.448000													5	169					0	0	1	0	0
RYK	6259	broad.mit.edu	37	3	133878181	133878181	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr3:133878181G>C	ENST00000427044.2	-	15	1655	c.1045C>G	c.(1045-1047)Ctg>Gtg	p.L349V	RYK_ENST00000296084.4_Missense_Mutation_p.L539V			P34925	RYK_HUMAN	receptor-like tyrosine kinase	535	Protein kinase.				corpus callosum development|positive regulation of MAPKKK cascade|Wnt receptor signaling pathway	cytoplasm|integral to plasma membrane|nucleus	ATP binding|transmembrane receptor protein tyrosine kinase activity	p.L539V(1)		lung(1)|ovary(3)	4						GTCTGGCCCAGAGTCATGAGT	0.522000													10	47					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179582510	179582510	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr2:179582510C>G	ENST00000589042.1	-	87	25315	c.25091G>C	c.(25090-25092)aGa>aCa	p.R8364T	TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.R7120T|TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.R8047T	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	8047	Ig-like 66.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTCAGTTTTCTTGCAAAGAA	0.413000													7	26					0	0	1	0	0
TMEM248	55069	broad.mit.edu	37	7	66418288	66418288	+	Missense_Mutation	SNP	T	T	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr7:66418288T>C	ENST00000341567.4	+	6	1111	c.856T>C	c.(856-858)Tgc>Cgc	p.C286R		NM_017994.4	NP_060464.1			transmembrane protein 248																		AACAATGTTTTGCTATGCTGT	0.423000													22	94					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105414321	105414321	+	Silent	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr14:105414321C>T	ENST00000333244.5	-	7	7586	c.7467G>A	c.(7465-7467)aaG>aaA	p.K2489K	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2489						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			ATGACGGCATCTTGAACTTGG	0.612000													63	336					0	0	1	0	0
NUDT16L1	84309	broad.mit.edu	37	16	4744970	4744970	+	Missense_Mutation	SNP	C	C	T	rs149968687		TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr16:4744970C>T	ENST00000586536.1	+	3	516	c.496C>T	c.(496-498)Cgt>Tgt	p.R166C	NUDT16L1_ENST00000586252.1_Intron|NUDT16L1_ENST00000405142.1_3'UTR|NUDT16L1_ENST00000304301.6_Silent_p.L142L	NM_001193452.1	NP_001180381.1	Q9BRJ7	SDOS_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 16-like 1	0	Interaction with PXN (By similarity).					cytoplasm	hydrolase activity			endometrium(1)|large_intestine(1)|lung(1)|skin(1)	4						TGCTGGGCCTCGTGCGGGTCC	0.647000													6	16					0	0	1	0	0
ZNF700	90592	broad.mit.edu	37	19	12060248	12060248	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr19:12060248G>C	ENST00000482090.1	+	3	1773	c.1355G>C	c.(1354-1356)gGa>gCa	p.G452A	CTD-2006C1.12_ENST00000586394.1_RNA|ZNF763_ENST00000590798.1_Intron|ZNF700_ENST00000254321.5_Missense_Mutation_p.G470A|ZNF763_ENST00000538752.1_Intron|ZNF763_ENST00000591944.1_Intron			Q9H0M5	ZN700_HUMAN	zinc finger protein 700	470					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		ZNF700/MAST1_ENST00000251472(2)	breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(13)|pancreas(1)|prostate(1)|urinary_tract(1)	33						ACTCATACTGGAGAGAAACCC	0.443000													17	50					0	0	1	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43846349	43846349	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr12:43846349G>A	ENST00000389420.3	-	13	1909	c.1910C>T	c.(1909-1911)tCt>tTt	p.S637F	ADAMTS20_ENST00000553158.1_Missense_Mutation_p.S637F	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	637	Cys-rich.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		CCTCACATTAGAGGGAATGCC	0.373000													6	33					0	0	1	0	0
EFNB3	1949	broad.mit.edu	37	17	7612627	7612627	+	Silent	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr17:7612627G>A	ENST00000226091.2	+	5	1153	c.756G>A	c.(754-756)cgG>cgA	p.R252R		NM_001406.3	NP_001397.1	Q15768	EFNB3_HUMAN	ephrin-B3	252					cell-cell signaling|interspecies interaction between organisms	integral to plasma membrane	ephrin receptor binding|transmembrane-ephrin receptor activity			large_intestine(3)|lung(2)|ovary(1)|prostate(1)|urinary_tract(1)	8		all_cancers(10;1.14e-06)|Prostate(122;0.081)				TGTGTTGGCGGAGACGGCGGG	0.726000													5	19					0	0	1	0	0
F13A1	2162	broad.mit.edu	37	6	6167819	6167819	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr6:6167819C>T	ENST00000264870.3	-	13	2045	c.1780G>A	c.(1780-1782)Gag>Aag	p.E594K		NM_000129.3	NP_000120.2	P00488	F13A_HUMAN	coagulation factor XIII, A1 polypeptide	594					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	62	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	CCCATGTACTCGCCGGCTTGG	0.522000													10	29					0	0	1	0	0
SPEF2	79925	broad.mit.edu	37	5	35704682	35704682	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr5:35704682C>G	ENST00000440995.2	+	17	2410	c.2410C>G	c.(2410-2412)Cac>Gac	p.H804D	CTD-2113L7.1_ENST00000510433.1_RNA|SPEF2_ENST00000356031.3_Missense_Mutation_p.H809D|SPEF2_ENST00000509059.1_Missense_Mutation_p.H804D			Q9C093	SPEF2_HUMAN	sperm flagellar 2	809					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	37	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TAAAACTGCTCACGAAGATAT	0.313000													10	38					0	0	1	0	0
AKAP4	8852	broad.mit.edu	37	X	49965527	49965527	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chrX:49965527G>C	ENST00000358526.2	-	1	137	c.14C>G	c.(13-15)tCt>tGt	p.S5C	AKAP4_ENST00000376056.2_5'UTR|AKAP4_ENST00000376058.2_5'UTR	NM_003886.2	NP_003877.2	Q5JQC9	AKAP4_HUMAN	A kinase (PRKA) anchor protein 4	5					cell projection organization|single fertilization|sperm motility	cAMP-dependent protein kinase complex|cilium|cytoskeleton|microtubule-based flagellum	protein kinase A binding			NS(2)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(6)|lung(14)|ovary(1)|skin(4)	41	Ovarian(276;0.236)					TGTAGTATCAGAGTACGCCAT	0.443000													20	43					0	0	1	0	0
TNIK	23043	broad.mit.edu	37	3	170819360	170819360	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr3:170819360C>G	ENST00000436636.2	-	22	2813	c.2469G>C	c.(2467-2469)atG>atC	p.M823I	TNIK_ENST00000470834.1_Missense_Mutation_p.M786I|TNIK_ENST00000475336.1_Missense_Mutation_p.M731I|TNIK_ENST00000341852.6_Missense_Mutation_p.M739I|TNIK_ENST00000460047.1_Missense_Mutation_p.M760I|TNIK_ENST00000488470.1_Missense_Mutation_p.M768I|TNIK_ENST00000538048.1_Missense_Mutation_p.M775I|TNIK_ENST00000369326.5_Missense_Mutation_p.M801I|TNIK_ENST00000357327.5_Missense_Mutation_p.M794I|TNIK_ENST00000284483.8_Missense_Mutation_p.M815I	NM_015028.2	NP_055843.1	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase	823	Mediates interaction with NEDD4.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(22)|ovary(5)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(2)	62	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			TCACCTTCTTCATTGGGCGGT	0.468000													27	173					0	0	1	0	0
TUBG2	27175	broad.mit.edu	37	17	40817761	40817761	+	Silent	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr17:40817761C>T	ENST00000251412.7	+	8	958	c.759C>T	c.(757-759)ctC>ctT	p.L253L		NM_016437.2	NP_057521.1	Q9NRH3	TBG2_HUMAN	tubulin, gamma 2	253					G2/M transition of mitotic cell cycle|microtubule-based process|protein polymerization	cytosol	GTP binding|GTPase activity|structural molecule activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)	15		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.141)		ACAATGACCTCATCGGCCTCA	0.622000													57	189					0	0	1	0	0
RRM1	6240	broad.mit.edu	37	11	4142861	4142861	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr11:4142861G>C	ENST00000300738.5	+	10	1108	c.904G>C	c.(904-906)Gag>Cag	p.E302Q	RRM1_ENST00000528470.1_3'UTR|RRM1_ENST00000423050.2_Missense_Mutation_p.E205Q|RRM1_ENST00000537197.1_5'UTR|RRM1_ENST00000534285.1_Missense_Mutation_p.E80Q	NM_001033.3	NP_001024.1	P23921	RIR1_HUMAN	ribonucleotide reductase M1	302					deoxyribonucleotide biosynthetic process|DNA replication|nucleobase, nucleoside and nucleotide interconversion	cytosol|nucleoplasm|ribonucleoside-diphosphate reductase complex	ATP binding|ribonucleoside-diphosphate reductase activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(7)|skin(2)	14		Medulloblastoma(188;0.0025)|Breast(177;0.00502)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0848)|LUSC - Lung squamous cell carcinoma(625;0.205)	Clofarabine(DB00631)|Fludarabine(DB01073)|Gemcitabine(DB00441)|Hydroxyurea(DB01005)	TATTTACCTGGAGCCTTGGCA	0.388000													14	38					0	0	1	0	0
FOXP1	27086	broad.mit.edu	37	3	71021784	71021784	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr3:71021784C>T	ENST00000318789.4	-	18	2099	c.1574G>A	c.(1573-1575)cGa>cAa	p.R525Q	FOXP1_ENST00000498215.1_Missense_Mutation_p.R525Q|FOXP1_ENST00000484350.1_Missense_Mutation_p.R449Q|FOXP1_ENST00000475937.1_Missense_Mutation_p.R525Q|FOXP1_ENST00000493089.1_Missense_Mutation_p.R524Q|FOXP1_ENST00000468577.1_Intron|FOXP1_ENST00000491238.1_Missense_Mutation_p.R527Q	NM_001244810.1|NM_001244813.1|NM_032682.5	NP_001231739.1|NP_001231742.1|NP_116071.2	Q9H334	FOXP1_HUMAN	forkhead box P1	525					cardiac muscle cell differentiation|embryo development|immunoglobulin V(D)J recombination|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of immunoglobulin production|positive regulation of mesenchymal cell proliferation|pre-B cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|skeletal muscle tissue development|smooth muscle tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(8)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	31		Lung NSC(201;4.62e-05)|Prostate(10;0.0181)|Hepatocellular(537;0.186)|Myeloproliferative disorder(1037;0.209)		BRCA - Breast invasive adenocarcinoma(55;1.17e-05)|Epithelial(33;1.39e-05)|LUSC - Lung squamous cell carcinoma(21;2.35e-05)|Lung(16;4.26e-05)		GTTTTCTACTCGCACAAAACA	0.388000			T	PAX5	ALL								9	51					0	0	1	0	0
HDAC3	8841	broad.mit.edu	37	5	141008863	141008863	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr5:141008863G>A	ENST00000305264.3	-	7	566	c.487C>T	c.(487-489)Cgg>Tgg	p.R163W		NM_003883.3	NP_003874.2	O15379	HDAC3_HUMAN	histone deacetylase 3	163	Histone deacetylase.				anti-apoptosis|cellular lipid metabolic process|negative regulation of cell cycle|negative regulation of JNK cascade|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|spindle assembly|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|spindle microtubule|transcriptional repressor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|transcription corepressor activity|transcription factor binding			endometrium(1)|large_intestine(2)|lung(3)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	13			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Vorinostat(DB02546)	TAGAGCACCCGAGGGTGGTAC	0.537000													6	63					0	0	1	0	0
KIAA1377	57562	broad.mit.edu	37	11	101828953	101828953	+	Missense_Mutation	SNP	G	G	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr11:101828953G>T	ENST00000263468.8	+	5	831	c.561G>T	c.(559-561)caG>caT	p.Q187H	KIAA1377_ENST00000537689.1_5'UTR	NM_020802.2	NP_065853.2	Q9P2H0	K1377_HUMAN	KIAA1377	187							protein binding			breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(18)|ovary(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	53	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)		ACAAGCATCAGAAACAACTCT	0.358000													50	213					2.52991e-16	2.75739e-16	1	1	0
ZMIZ1	57178	broad.mit.edu	37	10	81072426	81072426	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr10:81072426G>A	ENST00000334512.5	+	25	3696	c.3124G>A	c.(3124-3126)Gag>Aag	p.E1042K	ZMIZ1_ENST00000446377.2_Missense_Mutation_p.E108K	NM_020338.3	NP_065071.1	Q9ULJ6	ZMIZ1_HUMAN	zinc finger, MIZ-type containing 1	1042					transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(2)|prostate(3)|skin(1)	30	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			AAATCCTGACGAGCTCCTGTC	0.567000													48	217					0	0	1	0	0
HIAT1	64645	broad.mit.edu	37	1	100546054	100546054	+	Missense_Mutation	SNP	G	G	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr1:100546054G>T	ENST00000370152.3	+	11	1241	c.1105G>T	c.(1105-1107)Gtc>Ttc	p.V369F	RP4-714D9.2_ENST00000432294.1_RNA	NM_033055.2	NP_149044.2	Q96MC6	HIAT1_HUMAN	hippocampus abundant transcript 1	369					transmembrane transport	integral to membrane|plasma membrane	transporter activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(8)|skin(1)	16		all_epithelial(167;2.96e-06)|all_lung(203;0.00125)|Lung NSC(277;0.00131)		Epithelial(280;0.0832)|all cancers(265;0.136)|COAD - Colon adenocarcinoma(174;0.148)|Lung(183;0.195)		CAATGTAGGTGTCGTTCAAGG	0.348000													24	90					6.44725e-10	6.87707e-10	1	1	0
RPL22	6146	broad.mit.edu	37	1	6253099	6253099	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr1:6253099C>T	ENST00000234875.4	-	3	171	c.133G>A	c.(133-135)Gaa>Aaa	p.E45K	RPL22_ENST00000497965.1_Missense_Mutation_p.E12K|RPL22_ENST00000484532.1_Missense_Mutation_p.E12K	NM_000983.3	NP_000974.1	P35268	RL22_HUMAN	ribosomal protein L22	45					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	heparin binding|RNA binding|structural constituent of ribosome			kidney(1)|large_intestine(2)|lung(2)|skin(1)	6	Ovarian(185;0.0634)	all_cancers(23;2.78e-38)|all_epithelial(116;8.88e-22)|all_lung(118;7.95e-08)|Lung NSC(185;1.6e-06)|all_neural(13;3.18e-06)|all_hematologic(16;8.99e-06)|Acute lymphoblastic leukemia(12;0.000365)|Breast(487;0.000496)|Renal(390;0.0007)|Colorectal(325;0.00104)|Glioma(11;0.00203)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)|Medulloblastoma(700;0.211)		Epithelial(90;4.53e-38)|GBM - Glioblastoma multiforme(13;3.33e-32)|OV - Ovarian serous cystadenocarcinoma(86;2.8e-19)|Colorectal(212;6.8e-08)|COAD - Colon adenocarcinoma(227;8.04e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00107)|STAD - Stomach adenocarcinoma(132;0.00311)|READ - Rectum adenocarcinoma(331;0.0642)|Lung(427;0.182)		TTGATCCTTTCTTGCAAAAAC	0.438000			T	RUNX1	"""AML, CML"""								24	72					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178916876	178916876	+	Missense_Mutation	SNP	G	G	A	rs121913287		TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr3:178916876G>A	ENST00000263967.3	+	2	420	c.263G>A	c.(262-264)cGa>cAa	p.R88Q		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	88	PI3K-ABD.		R -> Q (in cancer; may disrupt the interaction between the PI3K-ABD domain and the N-terminal lobe of PI3K/PI4K kinase domain possibly affecting the conformation of the kinase domain).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.R88Q(53)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			GAAACAAGACGACTTTGTGAC	0.363000	R88Q(JHUEM1_ENDOMETRIUM)|R88Q(SKUT1_SOFT_TISSUE)|R88Q(SNGM_ENDOMETRIUM)	57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			40	100					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7673616	7673616	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr17:7673616G>C	ENST00000572933.1	+	25	5448	c.3988G>C	c.(3988-3990)Gaa>Caa	p.E1330Q	DNAH2_ENST00000389173.2_Missense_Mutation_p.E1330Q			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	1330	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				GTTTGATCAGGAATCTGAAAG	0.532000													9	68					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62294856	62294856	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr11:62294856C>G	ENST00000378024.4	-	5	7307	c.7033G>C	c.(7033-7035)Gaa>Caa	p.E2345Q	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	2345					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				ACATCCAATTCTGGACCTTTT	0.443000													38	153					0	0	1	0	0
CYP3A43	64816	broad.mit.edu	37	7	99445814	99445814	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr7:99445814G>C	ENST00000354829.2	+	6	561	c.458G>C	c.(457-459)gGa>gCa	p.G153A	CYP3A43_ENST00000477658.1_3'UTR|CYP3A43_ENST00000312017.5_Missense_Mutation_p.G153A|CYP3A43_ENST00000342499.4_Missense_Mutation_p.W15C|CYP3A43_ENST00000444905.1_Intron|CYP3A43_ENST00000222382.5_Missense_Mutation_p.G153A|CYP3A43_ENST00000415413.1_Intron|CYP3A43_ENST00000417625.1_Intron	NM_022820.3|NM_057095.1	NP_073731.1|NP_476436.1	Q9HB55	CP343_HUMAN	cytochrome P450, family 3, subfamily A, polypeptide 43	153			Missing (in allele CYP3A43*2).		xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|skin(1)	19	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)				Cetirizine(DB00341)|Doxycycline(DB00254)	TCCCAATGTGGAGATATGTTG	0.473000													6	33					0	0	1	0	0
OR7G3	390883	broad.mit.edu	37	19	9237262	9237262	+	Missense_Mutation	SNP	C	C	G	rs144765135		TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr19:9237262C>G	ENST00000305444.2	-	1	364	c.365G>C	c.(364-366)cGa>cCa	p.R122P		NM_001001958.1	NP_001001958.1	Q8NG95	OR7G3_HUMAN	olfactory receptor, family 7, subfamily G, member 3	122					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|endometrium(1)|large_intestine(3)|liver(1)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	15						GGCCACAAATCGATCATAGGC	0.473000													16	103					0	0	1	0	0
POLR1A	25885	broad.mit.edu	37	2	86280055	86280055	+	Silent	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr2:86280055G>A	ENST00000263857.6	-	16	2655	c.2277C>T	c.(2275-2277)taC>taT	p.Y759Y	POLR1A_ENST00000409681.1_Silent_p.Y759Y			O95602	RPA1_HUMAN	polymerase (RNA) I polypeptide A, 194kDa	759					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(8)|kidney(3)|large_intestine(12)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	63						GGACCAGGCCGTAGGCGGAGC	0.627000													13	25					0	0	1	0	0
CCDC114	93233	broad.mit.edu	37	19	48800551	48800551	+	Silent	SNP	G	G	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr19:48800551G>C	ENST00000315396.7	-	14	2377	c.1695C>G	c.(1693-1695)ctC>ctG	p.L565L		NM_144577.3	NP_653178.3	Q96M63	CC114_HUMAN	coiled-coil domain containing 114	565										cervix(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|stomach(1)	24		all_epithelial(76;9.64e-05)|all_lung(116;0.000147)|Lung NSC(112;0.000251)|Prostate(7;0.0187)|all_neural(266;0.0228)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000162)|Epithelial(262;0.0134)|GBM - Glioblastoma multiforme(486;0.0143)		TGCTGGAGCTGAGGCCGCCAA	0.642000													24	60					0	0	1	0	0
MTBP	27085	broad.mit.edu	37	8	121528214	121528214	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr8:121528214G>A	ENST00000305949.1	+	18	2074	c.2029G>A	c.(2029-2031)Gaa>Aaa	p.E677K		NM_022045.3	NP_071328.2	Q96DY7	MTBP_HUMAN	Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa	677	Interaction with MDM2 (By similarity).				cell cycle arrest					NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	30	Lung NSC(37;5.68e-08)|Ovarian(258;0.00769)|all_neural(195;0.0804)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00503)			AGGATTTTCTGAACTTCAGTC	0.403000													22	39					0	0	1	0	0
CD177	57126	broad.mit.edu	37	19	43866475	43866475	+	RNA	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr19:43866475C>G	ENST00000378009.4	+	0	1478				CD177_ENST00000607517.1_RNA|CTC-490G23.4_ENST00000607109.1_RNA	NM_020406.2	NP_065139.2	Q8N6Q3	CD177_HUMAN	CD177 molecule						blood coagulation|leukocyte migration	anchored to membrane|plasma membrane				central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	5		Prostate(69;0.00682)				CCTGCTAACTCTATTACCCCC	0.592000													3	10					0	0	1	0	0
PLCE1	51196	broad.mit.edu	37	10	96030304	96030304	+	Missense_Mutation	SNP	C	C	G	rs121912605		TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr10:96030304C>G	ENST00000260766.3	+	18	5085	c.4451C>G	c.(4450-4452)tCg>tGg	p.S1484W	PLCE1_ENST00000371375.1_Missense_Mutation_p.S1176W|PLCE1_ENST00000371380.2_Missense_Mutation_p.S1484W|PLCE1_ENST00000371385.3_Missense_Mutation_p.S1176W	NM_016341.3	NP_057425.3	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1	1484	PI-PLC X-box.		S -> L (in NPHS3; gives rise to focal segmental glomerulosclerosis rather than diffuse mesangial sclerosis).		activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			liver(1)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	8		Colorectal(252;0.0458)				ATCATCATATCGATTGAGAAC	0.438000													17	64					0	0	1	0	0
PPFIA3	8541	broad.mit.edu	37	19	49652942	49652942	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr19:49652942C>T	ENST00000334186.4	+	28	3842	c.3493C>T	c.(3493-3495)Ccg>Tcg	p.P1165S	PPFIA3_ENST00000602351.1_Missense_Mutation_p.P1156S	NM_003660.2	NP_003651.1	O75145	LIPA3_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3	1165						cell surface|cytoplasm	protein binding	p.G1160fs*>21(2)		NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(16)|pancreas(1)|prostate(1)|skin(4)|urinary_tract(1)	35		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.36e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000203)|GBM - Glioblastoma multiforme(486;0.00307)|Epithelial(262;0.00677)		CCTGGGCTCTCCGGGGCTCCC	0.642000													5	39					0	0	1	0	0
ARSE	415	broad.mit.edu	37	X	2854807	2854807	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chrX:2854807C>T	ENST00000545496.1	-	11	1753	c.1462G>A	c.(1462-1464)Gca>Aca	p.A488T	ARSE_ENST00000540563.1_Missense_Mutation_p.A418T|ARSE_ENST00000381134.3_Missense_Mutation_p.A463T			P51690	ARSE_HUMAN	arylsulfatase E (chondrodysplasia punctata 1)	463					skeletal system development	Golgi stack	arylsulfatase activity|metal ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CACCTGGCTGCGTGCAGAAAC	0.557000													11	7					0	0	1	0	0
RNASE3	6037	broad.mit.edu	37	14	21360228	21360228	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr14:21360228G>C	ENST00000304639.3	+	2	441	c.383G>C	c.(382-384)aGa>aCa	p.R128T		NM_002935.2	NP_002926.2	P12724	ECP_HUMAN	ribonuclease, RNase A family, 3	128					defense response to bacterium|RNA catabolic process	extracellular region|soluble fraction	nucleic acid binding|pancreatic ribonuclease activity			endometrium(1)|large_intestine(1)|lung(6)|ovary(1)	9	all_cancers(95;0.00453)		OV - Ovarian serous cystadenocarcinoma(11;6.3e-09)|Epithelial(56;1.42e-07)|all cancers(55;5.48e-07)	GBM - Glioblastoma multiforme(265;0.0187)	Pranlukast(DB01411)	TATGCAGACAGACCAGGAAGG	0.473000													22	62					0	0	1	0	0
NLRP10	338322	broad.mit.edu	37	11	7982421	7982421	+	Silent	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr11:7982421G>A	ENST00000328600.2	-	2	899	c.738C>T	c.(736-738)ttC>ttT	p.F246F		NM_176821.3	NP_789791.1	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	246	NACHT.						ATP binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CATCCAGGATGAACAGGAGCC	0.537000													4	63					0	0	1	0	0
FCHO2	115548	broad.mit.edu	37	5	72311471	72311471	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr5:72311471G>A	ENST00000430046.2	+	7	735	c.619G>A	c.(619-621)Gaa>Aaa	p.E207K	FCHO2_ENST00000512348.1_Intron|FCHO2_ENST00000341845.6_Missense_Mutation_p.E207K|FCHO2_ENST00000287761.6_Missense_Mutation_p.E207K	NM_001146032.1|NM_138782.2	NP_001139504.1|NP_620137.2	Q0JRZ9	FCHO2_HUMAN	FCH domain only 2	207										cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(4)|ovary(1)|prostate(1)	17		Lung NSC(167;0.0465)|Ovarian(174;0.0908)|Prostate(461;0.165)		OV - Ovarian serous cystadenocarcinoma(47;4.6e-53)		AGATATTGAAGAAACTCATCT	0.289000													5	29					0	0	1	0	0
NEDD9	4739	broad.mit.edu	37	6	11213618	11213618	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr6:11213618G>C	ENST00000379446.5	-	2	521	c.355C>G	c.(355-357)Caa>Gaa	p.Q119E	NEDD9_ENST00000504387.1_Missense_Mutation_p.Q119E|RP3-510L9.1_ENST00000500636.2_RNA|NEDD9_ENST00000379433.5_Missense_Mutation_p.Q119E	NM_001271033.1|NM_006403.3	NP_001257962.1|NP_006394.1	Q14511	CASL_HUMAN	neural precursor cell expressed, developmentally down-regulated 9	119	Interacts strongly with spindle- regulatory protein D1M1.				actin filament bundle assembly|cell adhesion|cell division|integrin-mediated signaling pathway|mitosis|regulation of growth	cell cortex|focal adhesion|Golgi apparatus|lamellipodium|nucleus	protein binding			endometrium(3)|kidney(2)|large_intestine(8)|liver(1)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26	Breast(50;0.0768)|Ovarian(93;0.152)	all_hematologic(90;0.135)	Epithelial(50;0.0647)|all cancers(50;0.179)			GTGGGGACTTGGTAAATTCCC	0.547000													10	158					0	0	1	0	0
ITSN2	50618	broad.mit.edu	37	2	24432036	24432036	+	Nonsense_Mutation	SNP	C	C	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr2:24432036C>A	ENST00000355123.4	-	36	4971	c.4528G>T	c.(4528-4530)Gag>Tag	p.E1510*	ITSN2_ENST00000361999.3_Nonsense_Mutation_p.E1483*	NM_006277.2	NP_006268.2	Q9NZM3	ITSN2_HUMAN	intersectin 2	1510	PH.				endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(8)|large_intestine(11)|liver(3)|lung(28)|ovary(2)|stomach(1)	61	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AAGACAGGCTCATCGCTGGAA	0.502000													6	49					8.12818e-05	8.31528e-05	1	1	0
HIVEP3	59269	broad.mit.edu	37	1	42047722	42047722	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr1:42047722G>A	ENST00000372584.1	-	3	3761	c.2747C>T	c.(2746-2748)tCa>tTa	p.S916L	HIVEP3_ENST00000372583.1_Missense_Mutation_p.S916L|HIVEP3_ENST00000429157.2_Missense_Mutation_p.S916L|HIVEP3_ENST00000247584.5_Missense_Mutation_p.S916L	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	916	No DNA binding activity or transactivation activity, but complete prevention of TRAF-dependent NF-Kappa-B activation; associates with TRAF2 and JUN (By similarity).|Ser-rich.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				CTCCCCTGATGATTGGGCCAT	0.597000													39	200					0	0	1	0	0
KEL	3792	broad.mit.edu	37	7	142658159	142658159	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr7:142658159G>A	ENST00000355265.2	-	4	730	c.256C>T	c.(256-258)Cgg>Tgg	p.R86W	KEL_ENST00000479768.2_5'UTR	NM_000420.2	NP_000411.1	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	86					proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(34)|ovary(3)|prostate(2)|skin(1)	60	Melanoma(164;0.059)					TAATGATCCCGGAGATCCAAA	0.542000													15	66					0	0	1	0	0
YY1AP1	55249	broad.mit.edu	37	1	155642519	155642519	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr1:155642519C>G	ENST00000368340.5	-	6	937	c.829G>C	c.(829-831)Gag>Cag	p.E277Q	YY1AP1_ENST00000295566.4_Missense_Mutation_p.E205Q|YY1AP1_ENST00000355499.4_Missense_Mutation_p.E139Q|MSTO1_ENST00000452804.2_Intron|YY1AP1_ENST00000311573.5_Missense_Mutation_p.E128Q|YY1AP1_ENST00000535662.1_Missense_Mutation_p.E5Q|YY1AP1_ENST00000438245.2_Missense_Mutation_p.E139Q|YY1AP1_ENST00000359205.5_Missense_Mutation_p.E128Q|YY1AP1_ENST00000407221.1_Missense_Mutation_p.E128Q|YY1AP1_ENST00000361831.5_Missense_Mutation_p.E128Q|YY1AP1_ENST00000476093.1_5'UTR|YY1AP1_ENST00000368330.2_Missense_Mutation_p.E139Q|YY1AP1_ENST00000368339.5_Missense_Mutation_p.E277Q|MSTO1_ENST00000538143.1_Intron|YY1AP1_ENST00000405763.3_Missense_Mutation_p.E277Q|YY1AP1_ENST00000347088.5_Missense_Mutation_p.E139Q|YY1AP1_ENST00000404643.1_Missense_Mutation_p.E139Q	NM_001198904.1	NP_001185833.1			YY1 associated protein 1											central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(7)|ovary(2)|skin(2)|urinary_tract(2)	31	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)					GTTCCCAGCTCTTTCTGGGAA	0.448000													6	57					0	0	1	0	0
VPS52	6293	broad.mit.edu	37	6	33232653	33232653	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr6:33232653C>T	ENST00000445902.2	-	13	1524	c.1306G>A	c.(1306-1308)Gac>Aac	p.D436N	VPS52_ENST00000482399.1_3'UTR|VPS52_ENST00000436044.2_Missense_Mutation_p.D311N|VPS52_ENST00000478934.1_5'UTR	NM_022553.4	NP_072047.4	Q8N1B4	VPS52_HUMAN	vacuolar protein sorting 52 homolog (S. cerevisiae)	436					protein transport	endosome membrane|Golgi apparatus				endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(8)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)	28						TCGTAGCAGTCAGCTAGATAA	0.448000													33	142					0	0	1	0	0
PRAMEF11	440560	broad.mit.edu	37	1	12885289	12885289	+	Silent	SNP	G	G	T	rs148273194	by1000genomes	TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr1:12885289G>T	ENST00000535591.1	-	4	1017	c.822C>A	c.(820-822)ctC>ctA	p.L274L		NM_001146344.1	NP_001139816.1	O60813	PRA11_HUMAN	PRAME family member 11	274								p.L274L(3)		NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|lung(7)|pancreas(2)|skin(4)|urinary_tract(1)	27						GGCACTGGGAGAGATGCTTCA	0.458000													7	319					2.0095e-06	2.08238e-06	1	1	0
HIVEP3	59269	broad.mit.edu	37	1	42045430	42045430	+	Missense_Mutation	SNP	G	G	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr1:42045430G>T	ENST00000372584.1	-	3	6053	c.5039C>A	c.(5038-5040)tCc>tAc	p.S1680Y	HIVEP3_ENST00000372583.1_Missense_Mutation_p.S1680Y|HIVEP3_ENST00000460604.1_5'UTR|HIVEP3_ENST00000429157.2_Missense_Mutation_p.S1680Y|HIVEP3_ENST00000247584.5_Missense_Mutation_p.S1680Y	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	1680					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				GGGCTTGCGGGAGCTGGATGG	0.512000													19	81					2.21704e-12	2.39033e-12	1	1	0
C22orf42	150297	broad.mit.edu	37	22	32555103	32555103	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr22:32555103C>T	ENST00000382097.3	-	1	172	c.100G>A	c.(100-102)Gag>Aag	p.E34K		NM_001010859.1	NP_001010859.1	Q6IC83	CV042_HUMAN	chromosome 22 open reading frame 42	34										NS(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(2)	24						GCCACAGTCTCAGGAATCTCA	0.577000													4	116					0	0	1	0	0
CCNB1IP1	57820	broad.mit.edu	37	14	20779857	20779857	+	Missense_Mutation	SNP	C	C	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr14:20779857C>A	ENST00000398169.3	-	7	1302	c.686G>T	c.(685-687)gGa>gTa	p.G229V	CCNB1IP1_ENST00000398163.2_Missense_Mutation_p.G229V|CCNB1IP1_ENST00000358932.4_Missense_Mutation_p.G229V|CCNB1IP1_ENST00000353689.4_Missense_Mutation_p.G229V|CCNB1IP1_ENST00000398160.2_Missense_Mutation_p.G229V|CCNB1IP1_ENST00000437553.2_Missense_Mutation_p.G229V			Q9NPC3	CIP1_HUMAN	cyclin B1 interacting protein 1, E3 ubiquitin protein ligase	229						chromosome|nucleus	ligase activity|metal ion binding|protein binding		HMGA2/CCNB1IP1(2)	breast(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)	9	all_cancers(95;0.00092)	all_lung(585;0.235)	Epithelial(56;8.86e-07)|all cancers(55;4.98e-06)	GBM - Glioblastoma multiforme(265;0.0164)		ATCTCCATCTCCATCGCCCCG	0.398000			T	HMGA2	leiomyoma								27	97					3.1745e-13	3.43189e-13	1	1	0
EHD1	10938	broad.mit.edu	37	11	64627491	64627491	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr11:64627491C>T	ENST00000320631.3	-	3	1074	c.820G>A	c.(820-822)Gag>Aag	p.E274K	EHD1_ENST00000359393.2_Missense_Mutation_p.E274K	NM_006795.2	NP_006786.2	Q9H4M9	EHD1_HUMAN	EH-domain containing 1	274					blood coagulation|cholesterol homeostasis|endocytic recycling|intracellular protein transport|low-density lipoprotein particle clearance|positive regulation of cholesterol storage|protein homooligomerization	early endosome membrane|lipid particle|plasma membrane|platelet dense tubular network membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)	12						TCCTGCTCCTCGGCCTCAAAG	0.612000													19	45					0	0	1	0	0
PVRL4	81607	broad.mit.edu	37	1	161049441	161049441	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr1:161049441C>G	ENST00000368012.3	-	2	680	c.378G>C	c.(376-378)gaG>gaC	p.E126D		NM_030916.2	NP_112178.2	Q96NY8	PVRL4_HUMAN	poliovirus receptor-related 4	126	Ig-like V-type 1.				adherens junction organization|cell adhesion|cell junction assembly	adherens junction|extracellular region|integral to membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|urinary_tract(1)	20	all_cancers(52;8.9e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)			TGACCCGGCACTCGTACTCGC	0.711000													8	26					0	0	1	0	0
FANCI	55215	broad.mit.edu	37	15	89807156	89807156	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr15:89807156G>A	ENST00000310775.7	+	8	654	c.568G>A	c.(568-570)Gag>Aag	p.E190K	FANCI_ENST00000300027.8_Missense_Mutation_p.E190K|FANCI_ENST00000567996.1_Missense_Mutation_p.E190K|FANCI_ENST00000451393.2_Missense_Mutation_p.E11K	NM_001113378.1	NP_001106849.1	Q9NVI1	FANCI_HUMAN	Fanconi anemia, complementation group I	190					cell cycle|DNA repair	nucleoplasm	protein binding			breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	Lung NSC(78;0.0472)|all_lung(78;0.089)					GACTGCAGAAGAGGTGGAATT	0.423000								Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				10	54					0	0	1	0	0
SLC4A10	57282	broad.mit.edu	37	2	162833336	162833336	+	Silent	SNP	G	G	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr2:162833336G>C	ENST00000375514.5	+	25	3524	c.3237G>C	c.(3235-3237)ctG>ctC	p.L1079L	SLC4A10_ENST00000272716.5_Silent_p.L1068L|SLC4A10_ENST00000421911.1_Intron|SLC4A10_ENST00000415876.2_Silent_p.L1068L|SLC4A10_ENST00000446997.1_Silent_p.L1098L	NM_001178016.1	NP_001171487.1	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate transporter, member 10	1098					bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(9)|lung(35)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						GGAACCTTCTGATTACTGCCG	0.338000													4	4					0	0	1	0	0
VGLL1	51442	broad.mit.edu	37	X	135618380	135618380	+	Silent	SNP	G	G	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chrX:135618380G>C	ENST00000370634.3	+	2	371	c.201G>C	c.(199-201)gtG>gtC	p.V67V		NM_016267.3	NP_057351.1	Q99990	VGLL1_HUMAN	vestigial like 1 (Drosophila)	67					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	transcription coactivator activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(7)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	20	Acute lymphoblastic leukemia(192;0.000127)					GTGAAGGTGTGATGCTGAAAA	0.527000													10	32					0	0	1	0	0
NUDT16	131870	broad.mit.edu	37	3	131102278	131102278	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr3:131102278G>A	ENST00000537561.1	+	4	547	c.472G>A	c.(472-474)Gag>Aag	p.E158K	NUDT16_ENST00000359850.3_3'UTR|NUDT16_ENST00000502852.1_3'UTR|NUDT16_ENST00000521288.1_3'UTR	NM_001171905.1	NP_001165376.1	Q96DE0	NUD16_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 16	0	Nudix hydrolase.					nucleolus|nucleoplasm	hydrolase activity|metal ion binding|RNA binding			large_intestine(1)|lung(6)	7						TATTGGATCTGAGAGATGATA	0.468000													4	7					0	0	1	0	0
MIR381HG	378881	broad.mit.edu	37	14	101513736	101513736	+	RNA	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr14:101513736C>G	ENST00000553692.1	+	0	28																											TTTTGAGTATCAAATCTTGCC	0.483000													3	20					0	0	1	0	0
ASPSCR1	79058	broad.mit.edu	37	17	79974881	79974881	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr17:79974881G>C	ENST00000306729.7	+	16	1919	c.1822G>C	c.(1822-1824)Gag>Cag	p.E608Q	ASPSCR1_ENST00000306739.4_Missense_Mutation_p.E514Q|ASPSCR1_ENST00000580534.1_Missense_Mutation_p.E462Q|ASPSCR1_ENST00000582404.1_3'UTR	NM_001251888.1	NP_001238817.1	Q9BZE9	ASPC1_HUMAN	alveolar soft part sarcoma chromosome region, candidate 1	514							protein binding		ASPSCR1/TFE3(167)	breast(2)|large_intestine(2)	4	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0191)			ACCTAAGTCTGAGCCAGCTGC	0.677000			T	TFE3	alveolar soft part sarcoma								10	49					0	0	1	0	0
SDF4	51150	broad.mit.edu	37	1	1158640	1158640	+	Silent	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr1:1158640G>A	ENST00000263741.7	-	4	853	c.561C>T	c.(559-561)ctC>ctT	p.L187L	SDF4_ENST00000360001.6_Silent_p.L187L|SDF4_ENST00000545427.1_Silent_p.L187L	NM_016176.3|NM_016547.2	NP_057260.2|NP_057631.1	Q9BRK5	CAB45_HUMAN	stromal cell derived factor 4	187					cerebellum development|fat cell differentiation|response to ethanol|UV protection|zymogen granule exocytosis	bleb|Golgi lumen|late endosome|soluble fraction	calcium ion binding|identical protein binding|protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	11	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;7.85e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.42e-21)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;4.83e-05)|Kidney(185;0.00252)|BRCA - Breast invasive adenocarcinoma(365;0.00263)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0368)|Lung(427;0.204)		CATCCACTTTGAGTTCCTCGT	0.562000													23	61					0	0	1	0	0
ADAMTS16	170690	broad.mit.edu	37	5	5190238	5190238	+	Missense_Mutation	SNP	C	C	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr5:5190238C>A	ENST00000274181.7	+	7	1340	c.1202C>A	c.(1201-1203)aCt>aAt	p.T401N	ADAMTS16_ENST00000511368.1_Missense_Mutation_p.T401N	NM_139056.2	NP_620687.2	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 16	401	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(72)|ovary(4)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	107						CCCTGTGACACTTTGGGTGAG	0.507000													5	88					1.23904e-05	1.27408e-05	1	1	0
HIVEP3	59269	broad.mit.edu	37	1	42050278	42050278	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr1:42050278G>A	ENST00000372584.1	-	3	1205	c.191C>T	c.(190-192)tCa>tTa	p.S64L	HIVEP3_ENST00000372583.1_Missense_Mutation_p.S64L|HIVEP3_ENST00000429157.2_Missense_Mutation_p.S64L|HIVEP3_ENST00000247584.5_Missense_Mutation_p.S64L	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	64					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				CCTAAGAACTGATGAGGGGCC	0.632000													35	191					0	0	1	0	0
GAL3ST2	64090	broad.mit.edu	37	2	242741215	242741215	+	Nonsense_Mutation	SNP	G	G	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr2:242741215G>T	ENST00000192314.6	+	3	270	c.139G>T	c.(139-141)Gag>Tag	p.E47*	AC114730.5_ENST00000437438.1_RNA	NM_022134.2	NP_071417.2	Q9H3Q3	G3ST2_HUMAN	galactose-3-O-sulfotransferase 2	47					biosynthetic process	Golgi cisterna membrane|integral to membrane	galactosylceramide sulfotransferase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(9)|prostate(1)|skin(1)	14		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;4.59e-33)|all cancers(36;9.89e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.89e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0833)		GGGCCAGGCTGAGGGGCCGCC	0.652000													15	34					6.31663e-08	6.64908e-08	1	1	0
SH3RF1	57630	broad.mit.edu	37	4	170077830	170077830	+	Splice_Site	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr4:170077830C>G	ENST00000284637.9	-	3	735	c.393_splice	c.e3-1	p.G132_splice	SH3RF1_ENST00000508685.1_5'UTR	NM_020870.3	NP_065921.2	Q7Z6J0	SH3R1_HUMAN	SH3 domain containing ring finger 1	132						Golgi apparatus|lamellipodium|perinuclear region of cytoplasm	ligase activity|zinc ion binding			NS(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(10)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	31		Prostate(90;0.00267)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)		TGAGGTATACCCTTTAAAAAA	0.328000													14	52					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62294601	62294601	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr11:62294601C>G	ENST00000378024.4	-	5	7562	c.7288G>C	c.(7288-7290)Gag>Cag	p.E2430Q	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	2430					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				TCTGGTCCCTCAATGTCAATG	0.468000													14	64					0	0	1	0	0
IL19	29949	broad.mit.edu	37	1	207010027	207010027	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr1:207010027C>T	ENST00000270218.6	+	3	959	c.20C>T	c.(19-21)tCc>tTc	p.S7F	IL19_ENST00000340758.2_Missense_Mutation_p.S45F	NM_013371.3	NP_037503.2	Q9UHD0	IL19_HUMAN	interleukin 19	7					apoptosis|immune response|signal transduction	extracellular space	cytokine activity			central_nervous_system(2)|large_intestine(1)|lung(2)|ovary(1)|stomach(1)	7			BRCA - Breast invasive adenocarcinoma(75;0.211)			CAGTGTGTTTCCCTTTGGCTC	0.478000													66	74					0	0	1	0	0
AOC2	314	broad.mit.edu	37	17	41001263	41001263	+	Silent	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr17:41001263C>G	ENST00000253799.3	+	2	1776	c.1749C>G	c.(1747-1749)ctC>ctG	p.L583L	AOC2_ENST00000452774.2_Silent_p.L583L	NM_009590.2	NP_033720.2	O75106	AOC2_HUMAN	amine oxidase, copper containing 2 (retina-specific)	583					catecholamine metabolic process|visual perception	cytoplasm|plasma membrane	aliphatic-amine oxidase activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|copper ion binding|electron carrier activity|phenethylamine:oxygen oxidoreductase (deaminating) activity|primary amine oxidase activity|quinone binding|tryptamine:oxygen oxidoreductase (deaminating) activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(14)|ovary(4)|skin(2)	30		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.156)		CCCGCTACCTCTACCTGGCTA	0.607000													33	133					0	0	1	0	0
ABCD1	215	broad.mit.edu	37	X	153008774	153008774	+	Silent	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chrX:153008774C>T	ENST00000218104.3	+	9	2364	c.1965C>T	c.(1963-1965)ctC>ctT	p.L655L	U52111.14_ENST00000434284.1_RNA	NM_000033.3	NP_000024.2	P33897	ABCD1_HUMAN	ATP-binding cassette, sub-family D (ALD), member 1	655	ABC transporter.				fatty acid beta-oxidation using acyl-CoA oxidase|peroxisomal membrane transport|peroxisome organization	cytosol|integral to peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|identical protein binding|peroxisomal fatty-acyl-CoA transporter activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(6)|urinary_tract(2)	18	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TTGCCCTGCTCTCCATCACCC	0.687000													3	6					0	0	1	0	0
STAB1	23166	broad.mit.edu	37	3	52541667	52541667	+	Silent	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr3:52541667G>A	ENST00000321725.6	+	19	2104	c.2028G>A	c.(2026-2028)acG>acA	p.T676T		NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1	676					cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		ACACCAGCACGTGTCCCCCCA	0.612000													13	54					0	0	1	0	0
NPAS2	4862	broad.mit.edu	37	2	101580639	101580639	+	Splice_Site	SNP	G	G	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr2:101580639G>T	ENST00000335681.5	+	8	1002		c.e8+1		NPAS2_ENST00000542504.1_Splice_Site	NM_002518.3	NP_002509.2	Q99743	NPAS2_HUMAN	neuronal PAS domain protein 2						central nervous system development|positive regulation of transcription from RNA polymerase II promoter|rhythmic process	transcription factor complex	DNA binding|Hsp90 protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			cervix(1)|endometrium(3)|large_intestine(7)|lung(9)|ovary(3)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						ATTCTTAAAGGCAAGTACCTG	0.443000													17	88					1.45105e-14	1.57296e-14	1	1	0
COL6A6	131873	broad.mit.edu	37	3	130293197	130293197	+	Silent	SNP	G	G	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr3:130293197G>C	ENST00000358511.6	+	7	3406	c.3375G>C	c.(3373-3375)ctG>ctC	p.L1125L	COL6A6_ENST00000453409.2_Silent_p.L1125L	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	1125	Nonhelical region.|VWFA 6.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						CGGAAGCCCTGAGACACAGAG	0.567000													26	107					0	0	1	0	0
SIMC1	375484	broad.mit.edu	37	5	175772396	175772396	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr5:175772396C>T	ENST00000443967.1	+	12	2974	c.2567C>T	c.(2566-2568)gCg>gTg	p.A856V	SIMC1_ENST00000430704.2_Missense_Mutation_p.A441V|SIMC1_ENST00000341199.6_Missense_Mutation_p.A441V|SIMC1_ENST00000332772.4_Missense_Mutation_p.A317V					SUMO-interacting motifs containing 1																		TTCTATGCTGCGGACTTGAAC	0.572000													9	44					0	0	1	0	0
FNBP4	23360	broad.mit.edu	37	11	47739054	47739054	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr11:47739054C>G	ENST00000263773.5	-	17	2986	c.2974G>C	c.(2974-2976)Gag>Cag	p.E992Q		NM_015308.2	NP_056123.2	Q8N3X1	FNBP4_HUMAN	formin binding protein 4	992										NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(12)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	44						GCATTTCTCTCTGCCATGCCA	0.328000													10	41					0	0	1	0	0
MT-CYB	4519	broad.mit.edu	37	MT	14996	14996	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chrM:14996G>A	ENST00000361789.2	+	1	250	c.250G>A	c.(250-252)Gcc>Acc	p.84_84insT						mitochondrially encoded cytochrome b											breast(6)|endometrium(25)|kidney(33)|prostate(1)	65						GCTACCTTCACGCCAATGGCG	0.483000													13	17					0	0	1	0	0
CEP164	22897	broad.mit.edu	37	11	117214932	117214932	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr11:117214932G>C	ENST00000278935.3	+	4	280	c.133G>C	c.(133-135)Gaa>Caa	p.E45Q		NM_014956.4	NP_055771.4	Q9UPV0	CE164_HUMAN	centrosomal protein 164kDa	45	Interaction with ATRIP.				cell division|DNA repair|G2/M transition of mitotic cell cycle|mitosis	centriole|cytosol|nucleus				breast(3)|central_nervous_system(1)|kidney(7)|large_intestine(12)|lung(18)|ovary(3)|prostate(3)	47	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;4e-05)|Epithelial(105;0.0008)		CAAGGAACCAGAACTGATGTG	0.532000													9	14					0	0	1	0	0
DPPA2	151871	broad.mit.edu	37	3	109028070	109028070	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr3:109028070G>A	ENST00000478945.1	-	4	535	c.289C>T	c.(289-291)Cgg>Tgg	p.R97W		NM_138815.3	NP_620170.3	Q7Z7J5	DPPA2_HUMAN	developmental pluripotency associated 2	97	SAP.					nucleus	nucleic acid binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(19)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						AAAGTGTCCCGACACACCTTA	0.448000													48	250					0	0	1	0	0
KIF21A	55605	broad.mit.edu	37	12	39727051	39727051	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr12:39727051C>G	ENST00000395670.3	-	18	2869	c.2450G>C	c.(2449-2451)aGa>aCa	p.R817T	KIF21A_ENST00000361961.3_Missense_Mutation_p.R804T|KIF21A_ENST00000544797.2_Missense_Mutation_p.R804T|KIF21A_ENST00000361418.5_Missense_Mutation_p.R817T|KIF21A_ENST00000541463.2_Intron			Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	817					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(41)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	86		Lung NSC(34;0.179)|all_lung(34;0.213)				TTCTTGGTTTCTTTTTTGGGC	0.328000													28	113					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179604916	179604916	+	Silent	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr2:179604916G>A	ENST00000589042.1	-	48	13268	c.13044C>T	c.(13042-13044)aaC>aaT	p.N4348N	TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000582847.1_RNA|TTN_ENST00000460472.2_Silent_p.N3985N|TTN_ENST00000359218.5_Silent_p.N4110N|TTN_ENST00000342992.6_Intron|TTN_ENST00000342175.6_Silent_p.N4177N|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000591111.1_Silent_p.N4031N	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	4031	Ig-like 23.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCATCACCACGTTGTCAGAAT	0.463000													10	58					0	0	1	0	0
ZKSCAN1	7586	broad.mit.edu	37	7	99621306	99621306	+	Missense_Mutation	SNP	C	C	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr7:99621306C>A	ENST00000324306.6	+	2	411	c.177C>A	c.(175-177)ttC>ttA	p.F59L	ZKSCAN1_ENST00000426572.1_Missense_Mutation_p.F23L|ZKSCAN1_ENST00000535170.1_Intron	NM_003439.1	NP_003430.1	P17029	ZKSC1_HUMAN	zinc finger with KRAB and SCAN domains 1	59	SCAN box.				viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(5)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	Lung NSC(181;0.0211)|all_lung(186;0.0323)|Esophageal squamous(72;0.0439)		STAD - Stomach adenocarcinoma(171;0.129)			GCCAACGCTTCAGGCGCTTCT	0.552000													27	68					8.24728e-16	8.96444e-16	1	1	0
FRYL	285527	broad.mit.edu	37	4	48546000	48546000	+	Missense_Mutation	SNP	C	C	G	rs955713		TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr4:48546000C>G	ENST00000537810.1	-	44	6020	c.5416G>C	c.(5416-5418)Gaa>Caa	p.E1806Q	FRYL_ENST00000264319.7_5'UTR|FRYL_ENST00000503238.1_Missense_Mutation_p.E1806Q|FRYL_ENST00000358350.4_Missense_Mutation_p.E1806Q|FRYL_ENST00000507873.2_5'UTR			O94915	FRYL_HUMAN	FRY-like	1806					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(21)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	91						AGATGATGTTCCAGATGAATT	0.408000													11	39					0	0	1	0	0
MCF2L	23263	broad.mit.edu	37	13	113699197	113699197	+	Silent	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr13:113699197C>T	ENST00000397021.1	+	1	222	c.159C>T	c.(157-159)ggC>ggT	p.G53G	MCF2L_ENST00000375597.4_Intron|MCF2L_ENST00000375608.3_Intron|MCF2L_ENST00000442652.2_Intron|MCF2L_ENST00000397030.1_Intron|MCF2L_ENST00000375601.3_Intron|MCF2L_ENST00000480321.1_3'UTR|MCF2L_ENST00000423482.2_Intron|MCF2L_ENST00000535094.2_Intron|MCF2L_ENST00000375604.2_Intron|MCF2L_ENST00000434480.2_Intron|MCF2L_ENST00000421756.1_Intron			O15068	MCF2L_HUMAN	MCF.2 cell line derived transforming sequence-like	388	CRAL-TRIO.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	Rho guanyl-nucleotide exchange factor activity			kidney(1)|large_intestine(5)|ovary(1)|stomach(1)	8	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0368)|all_epithelial(44;0.0396)|Lung NSC(25;0.129)|Breast(118;0.188)				CCAGGACCGGCGTGATGTATG	0.522000													3	45					0	0	1	0	0
ZNF493	284443	broad.mit.edu	37	19	21606712	21606712	+	Silent	SNP	T	T	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr19:21606712T>C	ENST00000392288.2	+	4	1360	c.1251T>C	c.(1249-1251)tcT>tcC	p.S417S	CTD-2561J22.3_ENST00000600810.1_Intron|ZNF493_ENST00000355504.4_Silent_p.S289S	NM_001076678.2	NP_001070146.1	Q6ZR52	ZN493_HUMAN	zinc finger protein 493	289					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	30						ATAAGGAGTCTTCACACCTTA	0.348000													3	44					0	0	1	0	0
TMEM120A	83862	broad.mit.edu	37	7	75621579	75621579	+	RNA	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr7:75621579C>T	ENST00000493111.2	-	0	200				TMEM120A_ENST00000338761.4_RNA			Q9BXJ8	T120A_HUMAN	transmembrane protein 120A							integral to membrane											GGGTTTGCATCTGCGGGTAAG	0.617000													4	84					0	0	1	0	0
AKAP9	10142	broad.mit.edu	37	7	91736691	91736691	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr7:91736691G>C	ENST00000359028.2	+	48	11738	c.11513G>C	c.(11512-11514)aGa>aCa	p.R3838T	AKAP9_ENST00000356239.3_Missense_Mutation_p.R3834T|AKAP9_ENST00000358100.2_Missense_Mutation_p.R3784T			Q99996	AKAP9_HUMAN	A kinase (PRKA) anchor protein 9	3838					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			NS(1)|autonomic_ganglia(2)|breast(14)|central_nervous_system(3)|cervix(1)|endometrium(13)|kidney(12)|large_intestine(35)|lung(49)|ovary(8)|prostate(6)|skin(8)|stomach(1)|urinary_tract(2)	155	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			TATCGCTCAAGATCAGATCTG	0.363000			T	BRAF	papillary thyroid								10	35					0	0	1	0	0
C4BPA	722	broad.mit.edu	37	1	207317276	207317276	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr1:207317276C>T	ENST00000367070.3	+	11	1752	c.1558C>T	c.(1558-1560)Ccc>Tcc	p.P520S		NM_000715.3	NP_000706.1	P04003	C4BPA_HUMAN	complement component 4 binding protein, alpha	520	Sushi 8.				complement activation, classical pathway|innate immune response	extracellular region	protein binding			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(7)|ovary(2)|skin(1)|urinary_tract(2)	28						TGTGGTTGGTCCCCAAAGTAT	0.478000													23	38					0	0	1	0	0
ADAMTS1	9510	broad.mit.edu	37	21	28217210	28217210	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr21:28217210C>T	ENST00000284984.2	-	1	518	c.64G>A	c.(64-66)Gag>Aag	p.E22K		NM_006988.3	NP_008919.3	Q9UHI8	ATS1_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 1	22					integrin-mediated signaling pathway|negative regulation of cell proliferation|proteolysis		heparin binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(20)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	42		Breast(209;0.000962)		Lung(58;0.215)		GGAGCCCGCTCCGCGTTCCCC	0.716000											OREG0026151	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	12					0	0	1	0	0
TMEM169	92691	broad.mit.edu	37	2	216960858	216960858	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr2:216960858G>A	ENST00000454545.1	+	3	498	c.172G>A	c.(172-174)Gac>Aac	p.D58N	TMEM169_ENST00000437356.2_Missense_Mutation_p.D58N|TMEM169_ENST00000406027.2_Missense_Mutation_p.D58N|TMEM169_ENST00000295658.4_Missense_Mutation_p.D58N	NM_001142310.1	NP_001135782.1	Q96HH4	TM169_HUMAN	transmembrane protein 169	58						integral to membrane				breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(2)	13		Renal(323;0.0651)		Epithelial(149;6.44e-06)|all cancers(144;0.000398)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CTACCGCTCAGACAATGAGAA	0.517000													10	43					0	0	1	0	0
RICTOR	253260	broad.mit.edu	37	5	38964982	38964982	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr5:38964982G>C	ENST00000357387.3	-	16	1342	c.1312C>G	c.(1312-1314)Ctt>Gtt	p.L438V	RICTOR_ENST00000296782.5_Missense_Mutation_p.L438V	NM_152756.3	NP_689969.2	Q6R327	RICTR_HUMAN	RPTOR independent companion of MTOR, complex 2	438					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(33)|ovary(3)|prostate(3)|skin(5)	75	all_lung(31;0.000396)					GAATGAGGAAGAATTGTGTTT	0.363000													7	24					0	0	1	0	0
IMMT	10989	broad.mit.edu	37	2	86371549	86371549	+	Missense_Mutation	SNP	C	C	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr2:86371549C>A	ENST00000410111.3	-	15	2506	c.2119G>T	c.(2119-2121)Gca>Tca	p.A707S	IMMT_ENST00000409051.2_Missense_Mutation_p.A660S|IMMT_ENST00000449247.2_Missense_Mutation_p.A696S|IMMT_ENST00000442664.2_Missense_Mutation_p.A706S|IMMT_ENST00000254636.5_Missense_Mutation_p.A608S	NM_001100169.1|NM_001100170.1|NM_006839.2	NP_001093639.1|NP_001093640.1|NP_006830.2	Q16891	IMMT_HUMAN	inner membrane protein, mitochondrial	707						integral to mitochondrial inner membrane	protein binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						ACAAACTTTGCTGCTAGCTCC	0.478000													18	61					5.03518e-11	5.38522e-11	1	1	0
FARS2	10667	broad.mit.edu	37	6	5369021	5369021	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr6:5369021G>C	ENST00000324331.6	+	2	554	c.218G>C	c.(217-219)aGa>aCa	p.R73T	FARS2_ENST00000274680.4_Missense_Mutation_p.R73T			O95363	SYFM_HUMAN	phenylalanyl-tRNA synthetase 2, mitochondrial	73					phenylalanyl-tRNA aminoacylation|tRNA processing	mitochondrial matrix|soluble fraction	ATP binding|magnesium ion binding|phenylalanine-tRNA ligase activity|tRNA binding			endometrium(3)|kidney(1)|large_intestine(5)|lung(3)|prostate(1)|stomach(2)	15	Ovarian(93;0.11)	all_hematologic(90;0.0104)			L-Phenylalanine(DB00120)	GTCCTCACCAGAGTTGGCAGG	0.587000													7	60					0	0	1	0	0
GRM6	2916	broad.mit.edu	37	5	178418925	178418925	+	Missense_Mutation	SNP	C	C	G	rs62638204		TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr5:178418925C>G	ENST00000231188.5	-	2	842	c.664G>C	c.(664-666)Gag>Cag	p.E222Q	GRM6_ENST00000517717.1_Missense_Mutation_p.E222Q	NM_000843.3	NP_000834.2	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6	222					detection of visible light|visual perception	integral to plasma membrane				NS(2)|breast(4)|endometrium(9)|large_intestine(12)|lung(21)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	55	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		TAGTTGCCCTCGGAGGCCAGC	0.617000													14	49					0	0	1	0	0
SLC2A2	6514	broad.mit.edu	37	3	170727825	170727825	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr3:170727825G>C	ENST00000314251.3	-	4	497	c.418C>G	c.(418-420)Ctc>Gtc	p.L140V	SLC2A2_ENST00000382808.4_Missense_Mutation_p.L21V	NM_000340.1	NP_000331.1	P11168	GTR2_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 2	140					carbohydrate metabolic process|cellular lipid metabolic process|endocrine pancreas development|energy reserve metabolic process|regulation of insulin secretion	integral to plasma membrane|membrane fraction	D-glucose transmembrane transporter activity			central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_cancers(22;1.41e-19)|all_lung(20;1.59e-15)|Lung NSC(18;7.08e-15)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;1.1e-14)|Lung(28;2.99e-14)			CCCATCAAGAGAGCTCCAACT	0.343000													8	64					0	0	1	0	0
NRAP	4892	broad.mit.edu	37	10	115374043	115374043	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr10:115374043C>G	ENST00000369358.4	-	29	3467	c.3223G>C	c.(3223-3225)Gag>Cag	p.E1075Q	NRAP_ENST00000360478.3_Missense_Mutation_p.E1032Q|NRAP_ENST00000369360.3_Missense_Mutation_p.E1040Q|NRAP_ENST00000359988.3_Missense_Mutation_p.E1067Q			Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein	1067						fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(18)|lung(39)|ovary(6)|prostate(3)|skin(1)|stomach(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		TCAAATGCCTCTTTGTATTTG	0.463000													20	91					0	0	1	0	0
SIN3A	25942	broad.mit.edu	37	15	75676757	75676757	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr15:75676757C>G	ENST00000394947.3	-	17	3357	c.3043G>C	c.(3043-3045)Gag>Cag	p.E1015Q	SIN3A_ENST00000360439.4_Missense_Mutation_p.E1015Q|SIN3A_ENST00000394949.4_Missense_Mutation_p.E1015Q	NM_001145358.1	NP_001138830.1	Q96ST3	SIN3A_HUMAN	SIN3 transcription regulator family member A	1015					blood coagulation|cellular lipid metabolic process|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|Sin3 complex	protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(15)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	63						ACACAGATCTCATCACTCACG	0.468000													10	59					0	0	1	0	0
SULT1A2	6799	broad.mit.edu	37	16	28606873	28606873	+	Nonsense_Mutation	SNP	G	G	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr16:28606873G>C	ENST00000533150.1	-	2	1388	c.272C>G	c.(271-273)tCa>tGa	p.S91*	SULT1A2_ENST00000335715.4_Nonsense_Mutation_p.S91*|SULT1A2_ENST00000395630.1_Nonsense_Mutation_p.S91*			P50226	ST1A2_HUMAN	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2	91					3'-phosphoadenosine 5'-phosphosulfate metabolic process|amine biosynthetic process|catecholamine metabolic process|steroid metabolic process|sulfation|xenobiotic metabolic process	cytosol	aryl sulfotransferase activity|flavonol 3-sulfotransferase activity			NS(2)|breast(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(3)|skin(2)	14						ACACACACCTGAGGGAATCCC	0.587000													15	73					0	0	1	0	0
MYH15	22989	broad.mit.edu	37	3	108140005	108140005	+	Silent	SNP	T	T	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr3:108140005T>C	ENST00000273353.3	-	29	3875	c.3819A>G	c.(3817-3819)gcA>gcG	p.A1273A		NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	1273						myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						TATCTAGCTTTGCAGTTGCTT	0.458000													37	124					0	0	1	0	0
LINC00264	645528	broad.mit.edu	37	10	26880266	26880266	+	RNA	SNP	G	G	A	rs138111133	by1000genomes	TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr10:26880266G>A	ENST00000412114.1	+	0	501					NR_026793.1																						ACCAAGCCCAGTGGACAGATG	0.443000													4	46					0	0	1	0	0
TCHH	7062	broad.mit.edu	37	1	152081441	152081441	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr1:152081441C>T	ENST00000368804.1	-	2	4251	c.4252G>A	c.(4252-4254)Gag>Aag	p.E1418K		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	1418	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTTCCTCCTCGCGGAATTTT	0.582000													36	135					0	0	1	0	0
KIAA1551	55196	broad.mit.edu	37	12	32135582	32135582	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr12:32135582C>G	ENST00000312561.4	+	4	2107	c.1693C>G	c.(1693-1695)Ccc>Gcc	p.P565A	KIAA1551_ENST00000535596.1_Intron	NM_018169.3	NP_060639.3			KIAA1551																		AATTTCTGTTCCCAAGTCCAT	0.378000													9	31					0	0	1	0	0
GPR176	11245	broad.mit.edu	37	15	40212072	40212072	+	Missense_Mutation	SNP	G	G	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr15:40212072G>T	ENST00000299092.3	-	1	354	c.156C>A	c.(154-156)ttC>ttA	p.F52L	GPR176_ENST00000561100.1_Missense_Mutation_p.F52L	NM_001271854.1|NM_001271855.1	NP_001258783.1|NP_001258784.1	Q14439	GP176_HUMAN	G protein-coupled receptor 176	52					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity			central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(3)|liver(1)|lung(9)|ovary(2)|pancreas(1)|skin(2)	23		all_cancers(109;4.05e-15)|all_epithelial(112;2.96e-13)|Lung NSC(122;8.53e-11)|all_lung(180;2.71e-09)|Melanoma(134;0.091)|Colorectal(260;0.198)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;4.4e-06)|BRCA - Breast invasive adenocarcinoma(123;0.123)		GCGAGCCTATGAAGATGACGA	0.736000													4	15					1.23904e-05	1.27408e-05	1	1	0
AMH	268	broad.mit.edu	37	19	2251939	2251939	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr19:2251939G>A	ENST00000221496.3	+	5	2332	c.1666G>A	c.(1666-1668)Gag>Aag	p.E556K		NM_000479.3	NP_000470.2	P03971	MIS_HUMAN	anti-Mullerian hormone	556					cell differentiation|cell-cell signaling|gonadal mesoderm development|Mullerian duct regression|positive regulation of gene expression|sex determination	extracellular space	growth factor activity|hormone activity			lung(2)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGTGGCCACCGAGTGTGGCTG	0.706000									Persistant Mullerian Duct Syndrome (type I and II)				3	9					0	0	1	0	0
PDZD2	23037	broad.mit.edu	37	5	32090179	32090179	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr5:32090179G>A	ENST00000438447.1	+	20	7013	c.6625G>A	c.(6625-6627)Gag>Aag	p.E2209K	PDZD2_ENST00000282493.3_Missense_Mutation_p.E2209K			O15018	PDZD2_HUMAN	PDZ domain containing 2	2209					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				NS(2)|breast(4)|central_nervous_system(5)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(31)|lung(58)|ovary(6)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	148						CCCCTCGGGGGAGGACCATCT	0.587000													61	247					0	0	1	0	0
CROCC	9696	broad.mit.edu	37	1	17257809	17257809	+	Silent	SNP	C	C	T	rs144262827		TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr1:17257809C>T	ENST00000375541.5	+	8	942	c.873C>T	c.(871-873)aaC>aaT	p.N291N	CROCC_ENST00000467938.1_3'UTR	NM_014675.3	NP_055490.3	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil, rootletin	291					cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			breast(3)|central_nervous_system(2)|cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(1)|lung(20)|ovary(3)|prostate(9)|skin(3)|urinary_tract(1)	62		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		ACTTCAGCAACGAGCACAGTC	0.622000													22	119					0	0	1	0	0
MEP1B	4225	broad.mit.edu	37	18	29782855	29782855	+	Splice_Site	SNP	G	G	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr18:29782855G>T	ENST00000269202.6	+	6	297		c.e6-1		MEP1B_ENST00000581447.1_Splice_Site	NM_005925.2	NP_005916.2	Q16820	MEP1B_HUMAN	meprin A, beta						digestion|proteolysis	extracellular space|integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(9)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23						TCTTCCTTCAGAAATGAATGC	0.348000													4	8					1.23904e-05	1.27408e-05	1	1	0
ZNF253	56242	broad.mit.edu	37	19	20002778	20002778	+	Nonsense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr19:20002778C>G	ENST00000589717.1	+	4	814	c.722C>G	c.(721-723)tCa>tGa	p.S241*	ZNF253_ENST00000355650.4_Nonsense_Mutation_p.S165*	NM_021047.2	NP_066385.2	O75346	ZN253_HUMAN	zinc finger protein 253	241				Missing (in Ref. 1; AAC26844).	negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(6)|lung(11)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						AAGCAGTCCTCAAACCTTACT	0.403000													13	50					0	0	1	0	0
SENP7	57337	broad.mit.edu	37	3	101090902	101090902	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr3:101090902C>T	ENST00000394095.2	-	7	799	c.746G>A	c.(745-747)cGa>cAa	p.R249Q	SENP7_ENST00000358203.3_Missense_Mutation_p.R85Q|SENP7_ENST00000394094.2_Missense_Mutation_p.R184Q|SENP7_ENST00000394091.1_Missense_Mutation_p.R85Q|SENP7_ENST00000314261.7_Missense_Mutation_p.R183Q|SENP7_ENST00000348610.3_Missense_Mutation_p.R216Q	NM_020654.3	NP_065705.3	Q9BQF6	SENP7_HUMAN	SUMO1/sentrin specific peptidase 7	249					proteolysis	nucleus	cysteine-type peptidase activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(16)|lung(15)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						ATCCTTTCTTCGTTTTTCTTT	0.353000													10	44					0	0	1	0	0
IQGAP1	8826	broad.mit.edu	37	15	91029307	91029307	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr15:91029307C>G	ENST00000268182.5	+	31	4091	c.3967C>G	c.(3967-3969)Cca>Gca	p.P1323A	IQGAP1_ENST00000560738.1_Missense_Mutation_p.P751A	NM_003870.3	NP_003861.1	P46940	IQGA1_HUMAN	IQ motif containing GTPase activating protein 1	1323	C2.				energy reserve metabolic process|regulation of insulin secretion|small GTPase mediated signal transduction	actin filament|cytoplasm|midbody|nucleus|plasma membrane	calmodulin binding|GTPase inhibitor activity|protein phosphatase binding|Ras GTPase activator activity			breast(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(14)|liver(1)|lung(18)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59	Melanoma(11;0.00551)|Lung NSC(78;0.0237)|all_lung(78;0.0488)		BRCA - Breast invasive adenocarcinoma(143;0.0745)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			GCACAATGATCCAATCCACGA	0.502000													7	18					0	0	1	0	0
TMEM169	92691	broad.mit.edu	37	2	216960780	216960780	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr2:216960780G>C	ENST00000454545.1	+	3	420	c.94G>C	c.(94-96)Gat>Cat	p.D32H	TMEM169_ENST00000437356.2_Missense_Mutation_p.D32H|TMEM169_ENST00000406027.2_Missense_Mutation_p.D32H|TMEM169_ENST00000295658.4_Missense_Mutation_p.D32H	NM_001142310.1	NP_001135782.1	Q96HH4	TM169_HUMAN	transmembrane protein 169	32						integral to membrane				breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(2)	13		Renal(323;0.0651)		Epithelial(149;6.44e-06)|all cancers(144;0.000398)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCTGGCGCTGGATGGGGAATC	0.552000													15	67					0	0	1	0	0
UBR3	130507	broad.mit.edu	37	2	170938325	170938325	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr2:170938325G>C	ENST00000272793.5	+	39	5689	c.5639G>C	c.(5638-5640)aGa>aCa	p.R1880T	UBR3_ENST00000392631.1_Missense_Mutation_p.R701T|UBR3_ENST00000418381.1_Missense_Mutation_p.R1880T			Q6ZT12	UBR3_HUMAN	ubiquitin protein ligase E3 component n-recognin 3 (putative)	1880					sensory perception of smell|suckling behavior|ubiquitin-dependent protein catabolic process	integral to membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(9)|liver(1)|lung(8)|ovary(1)|prostate(3)|stomach(1)	33						ATCAATAAAAGATGGGGTCCA	0.373000													10	51					0	0	1	0	0
LRRTM1	347730	broad.mit.edu	37	2	80529668	80529668	+	Missense_Mutation	SNP	T	T	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr2:80529668T>A	ENST00000295057.3	-	2	1933	c.1277A>T	c.(1276-1278)cAc>cTc	p.H426L	CTNNA2_ENST00000541047.1_Intron|CTNNA2_ENST00000496558.1_Intron|CTNNA2_ENST00000361291.4_Intron|CTNNA2_ENST00000540488.1_Intron|CTNNA2_ENST00000466387.1_Intron|CTNNA2_ENST00000402739.4_Intron|LRRTM1_ENST00000409148.1_Missense_Mutation_p.H426L	NM_178839.4	NP_849161.2	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	426						axon|endoplasmic reticulum membrane|growth cone|integral to membrane				NS(1)|breast(1)|endometrium(5)|large_intestine(7)|liver(1)|lung(33)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	63						GACCACCTTGTGGATCTGCAC	0.657000										HNSCC(69;0.2)			21	53					0	0	1	0	0
CSNK2A2	1459	broad.mit.edu	37	16	58201591	58201591	+	Nonsense_Mutation	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr16:58201591G>A	ENST00000262506.3	-	7	805	c.622C>T	c.(622-624)Cag>Tag	p.Q208*	CSNK2A2_ENST00000566813.1_5'UTR	NM_001896.2	NP_001887.1	P19784	CSK22_HUMAN	casein kinase 2, alpha prime polypeptide	208	Protein kinase.				axon guidance|Wnt receptor signaling pathway	cytosol|nucleus	ATP binding|protein N-terminus binding|protein serine/threonine kinase activity			central_nervous_system(1)	1						AAGTTTACCTGATAGTCCACG	0.438000													20	43					0	0	1	0	0
GPT2	84706	broad.mit.edu	37	16	46960843	46960843	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr16:46960843C>G	ENST00000440783.2	+	11	1740	c.1075C>G	c.(1075-1077)Caa>Gaa	p.Q359E	GPT2_ENST00000340124.4_Missense_Mutation_p.Q459E	NM_001142466.1	NP_001135938.1	Q8TD30	ALAT2_HUMAN	glutamic pyruvate transaminase (alanine aminotransferase) 2	459					2-oxoglutarate metabolic process|cellular amino acid biosynthetic process|L-alanine metabolic process	mitochondrial matrix	L-alanine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(2)	23		all_cancers(37;0.0276)|all_epithelial(9;0.0498)|all_lung(18;0.0522)			L-Alanine(DB00160)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	ATAGGCCCATCAAATGGCTCC	0.517000													13	42					0	0	1	0	0
FANCF	2188	broad.mit.edu	37	11	22646256	22646256	+	Silent	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr11:22646256G>A	ENST00000327470.3	-	1	1131	c.1101C>T	c.(1099-1101)ctC>ctT	p.L367L		NM_022725.3	NP_073562.1	Q9NPI8	FANCF_HUMAN	Fanconi anemia, complementation group F	367					DNA repair	nucleoplasm	protein binding			kidney(3)|large_intestine(3)|lung(6)|skin(1)	13						GGCCTGCGCTGAGACCCAAAA	0.378000			"""N, F"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia		OREG0020844	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	26	70					0	0	1	0	0
ACSS1	84532	broad.mit.edu	37	20	25003652	25003652	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr20:25003652G>A	ENST00000537502.1	-	3	2166	c.635C>T	c.(634-636)tCa>tTa	p.S212L	ACSS1_ENST00000432802.2_Missense_Mutation_p.S295L|ACSS1_ENST00000323482.4_Missense_Mutation_p.S295L|ACSS1_ENST00000542618.1_Missense_Mutation_p.S174L			Q9NUB1	ACS2L_HUMAN	acyl-CoA synthetase short-chain family member 1	295					acetyl-CoA biosynthetic process|ethanol oxidation|xenobiotic metabolic process	mitochondrial matrix	acetate-CoA ligase activity|AMP binding|ATP binding|protein binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	26					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	GGTGCTCCCTGAGGTGTACAG	0.597000													11	36					0	0	1	0	0
AMBP	259	broad.mit.edu	37	9	116825030	116825030	+	Silent	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr9:116825030C>T	ENST00000265132.3	-	7	874	c.612G>A	c.(610-612)cgG>cgA	p.R204R		NM_001633.3	NP_001624.1	P02760	AMBP_HUMAN	alpha-1-microglobulin/bikunin precursor	204					cell adhesion|female pregnancy|heme catabolic process|interspecies interaction between organisms|negative regulation of immune response|negative regulation of JNK cascade|protein-chromophore linkage	extracellular region|plasma membrane	calcium channel inhibitor activity|calcium oxalate binding|heme binding|IgA binding|protein homodimerization activity|serine-type endopeptidase inhibitor activity|transporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(4)|skin(1)	11					Human Serum Albumin(DB00062)|Serum albumin iodonated(DB00064)	GCACAGCCCTCCGGACTCTCT	0.507000													9	53					0	0	1	0	0
HIVEP3	59269	broad.mit.edu	37	1	42045758	42045758	+	Missense_Mutation	SNP	G	G	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr1:42045758G>T	ENST00000372584.1	-	3	5725	c.4711C>A	c.(4711-4713)Ctg>Atg	p.L1571M	HIVEP3_ENST00000372583.1_Missense_Mutation_p.L1571M|HIVEP3_ENST00000429157.2_Missense_Mutation_p.L1571M|HIVEP3_ENST00000247584.5_Missense_Mutation_p.L1571M	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	1571					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				GACAGAGGCAGAGAGCTCGGA	0.532000													22	108					4.35082e-09	4.60404e-09	1	1	0
OR6F1	343169	broad.mit.edu	37	1	247875358	247875358	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr1:247875358G>A	ENST00000302084.2	-	1	747	c.700C>T	c.(700-702)Cgg>Tgg	p.R234W	RP11-634B7.4_ENST00000449298.1_RNA	NM_001005286.1	NP_001005286.1	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F, member 1	234					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(1)|large_intestine(5)|lung(34)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)	47	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)			GCTTTGCTCCGGCCACTGGCA	0.522000													63	118					0	0	1	0	0
TNPO2	30000	broad.mit.edu	37	19	12829958	12829958	+	Silent	SNP	G	G	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr19:12829958G>C	ENST00000425528.1	-	5	567	c.210C>G	c.(208-210)ctC>ctG	p.L70L	TNPO2_ENST00000441499.1_Silent_p.L70L|TNPO2_ENST00000450764.2_Silent_p.L70L|TNPO2_ENST00000588216.1_Silent_p.L70L|TNPO2_ENST00000356861.5_Silent_p.L70L|TNPO2_ENST00000592287.1_Silent_p.L70L|TNPO2_ENST00000589956.1_5'UTR			O14787	TNPO2_HUMAN	transportin 2	70	Importin N-terminal.				intracellular protein transport	cytoplasm|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(2)|large_intestine(2)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						CGTTGTTCTTGAGGATGAGGC	0.577000													21	60					0	0	1	0	0
KIDINS220	57498	broad.mit.edu	37	2	8890400	8890400	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr2:8890400C>T	ENST00000256707.3	-	24	3437	c.3256G>A	c.(3256-3258)Gag>Aag	p.E1086K	KIDINS220_ENST00000473731.1_Missense_Mutation_p.E1086K|KIDINS220_ENST00000427284.1_Missense_Mutation_p.E1086K|KIDINS220_ENST00000418530.1_Missense_Mutation_p.E1044K	NM_020738.2	NP_065789.1	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate, 220kDa	1086					activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(25)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	60	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					GGAGGACCCTCATGTAGAGGG	0.582000													16	65					0	0	1	0	0
DESI2	51029	broad.mit.edu	37	1	244869039	244869039	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr1:244869039C>T	ENST00000302550.11	+	5	912	c.533C>T	c.(532-534)tCc>tTc	p.S178F	DESI2_ENST00000263831.7_Missense_Mutation_p.S145F	NM_016076.3	NP_057160.2	Q9BSY9	PPDE1_HUMAN	desumoylating isopeptidase 2	178																	GCATCCGCTTCCGTGGCAAGC	0.567000													18	74					0	0	1	0	0
PLEKHG2	64857	broad.mit.edu	37	19	39915990	39915990	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr19:39915990C>G	ENST00000458508.2	+	20	3811	c.3685C>G	c.(3685-3687)Cag>Gag	p.Q1229E	PLEKHG2_ENST00000425673.1_3'UTR|PLEKHG2_ENST00000409797.2_3'UTR|PLEKHG2_ENST00000409794.3_3'UTR			Q9H7P9	PKHG2_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 2	0					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(2)|liver(1)|lung(13)|pancreas(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	40	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CATAGACCCTCAGAACTTGAC	0.572000													3	35					0	0	1	0	0
BOK	666	broad.mit.edu	37	2	242511758	242511758	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr2:242511758C>T	ENST00000318407.3	+	5	862	c.560C>T	c.(559-561)tCc>tTc	p.S187F		NM_032515.4	NP_115904.1	Q9UMX3	BOK_HUMAN	BCL2-related ovarian killer	187					activation of caspase activity|cell proliferation|signal transduction by p53 class mediator resulting in induction of apoptosis	mitochondrial membrane|nucleus				large_intestine(1)|lung(3)|ovary(1)	5		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;2.04e-33)|all cancers(36;7.87e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.52e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.64e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0835)		GGCCTCCGCTCCCACTGGCTG	0.642000													7	24					0	0	1	0	0
EML1	2009	broad.mit.edu	37	14	100363537	100363537	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr14:100363537G>C	ENST00000262233.6	+	7	872	c.733G>C	c.(733-735)Gag>Cag	p.E245Q	EML1_ENST00000334192.4_Missense_Mutation_p.E264Q|EML1_ENST00000327921.9_Missense_Mutation_p.E233Q	NM_004434.2	NP_004425.2	O00423	EMAL1_HUMAN	echinoderm microtubule associated protein like 1	245						cytoplasm|microtubule|microtubule associated complex	calcium ion binding|protein binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Melanoma(154;0.0879)|all_epithelial(191;0.216)				TCCGACGGGAGAGACCGTCTA	0.488000													19	64					0	0	1	0	0
OR10A4	283297	broad.mit.edu	37	11	6897953	6897953	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr11:6897953G>C	ENST00000379829.2	+	1	98	c.75G>C	c.(73-75)caG>caC	p.Q25H		NM_207186.2	NP_997069.2	Q9H209	O10A4_HUMAN	olfactory receptor, family 10, subfamily A, member 4	25					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(2)|liver(2)|lung(20)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	31		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CTGAGCTTCAGGCTCTACTGT	0.458000													35	101					0	0	1	0	0
DIP2B	57609	broad.mit.edu	37	12	51126172	51126172	+	Silent	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr12:51126172C>T	ENST00000301180.5	+	32	3868	c.3834C>T	c.(3832-3834)tgC>tgT	p.C1278C		NM_173602.2	NP_775873.2	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B (Drosophila)	1278						nucleus	catalytic activity|transcription factor binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(15)|lung(18)|ovary(4)|pancreas(1)|prostate(1)|skin(6)|urinary_tract(2)	60						ACCTCTCCTGCGTCCGGACCT	0.562000													15	75					0	0	1	0	0
PTDSS1	9791	broad.mit.edu	37	8	97299290	97299290	+	Silent	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr8:97299290C>T	ENST00000517309.1	+	4	683	c.357C>T	c.(355-357)ctC>ctT	p.L119L	PTDSS1_ENST00000455950.2_Intron|PTDSS1_ENST00000518776.1_3'UTR	NM_014754.1	NP_055569.1	P48651	PTSS1_HUMAN	phosphatidylserine synthase 1	119					phosphatidylserine biosynthetic process	integral to membrane	transferase activity			endometrium(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(1)|prostate(1)|stomach(1)	29	Breast(36;6.18e-05)				Phosphatidylserine(DB00144)	TATTCCTACTCTTCCTGAATT	0.413000													36	139					0	0	1	0	0
SAMD4B	55095	broad.mit.edu	37	19	39874164	39874164	+	Silent	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr19:39874164C>T	ENST00000314471.6	+	16	3117	c.2082C>T	c.(2080-2082)atC>atT	p.I694I	SAMD4B_ENST00000598913.1_Intron|SAMD4B_ENST00000596368.1_Intron	NM_018028.2	NP_060498.2	Q5PRF9	SMAG2_HUMAN	sterile alpha motif domain containing 4B	694							protein binding			autonomic_ganglia(1)|breast(1)|endometrium(5)|large_intestine(1)|lung(4)|skin(1)|urinary_tract(2)	15	all_cancers(60;2.5e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;9.6e-28)|all cancers(26;9.14e-25)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			CCTCCACCATCTGACGGGACC	0.647000													38	107					0	0	1	0	0
MAGEB16	139604	broad.mit.edu	37	X	35820394	35820394	+	Silent	SNP	T	T	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chrX:35820394T>C	ENST00000399989.1	+	2	360	c.81T>C	c.(79-81)gtT>gtC	p.V27V	MAGEB16_ENST00000399992.1_Silent_p.V59V|MAGEB16_ENST00000399987.1_Silent_p.V27V|MAGEB16_ENST00000399988.1_Silent_p.V27V|MAGEB16_ENST00000399985.1_Silent_p.V27V	NM_001099921.1	NP_001093391.1	A2A368	MAGBG_HUMAN	melanoma antigen family B, 16	27										breast(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(16)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	31						GCCTGGAGGTTGCACAGGTCT	0.562000													15	13					0	0	1	0	0
MAP1B	4131	broad.mit.edu	37	5	71492935	71492935	+	Silent	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr5:71492935C>T	ENST00000296755.7	+	5	4051	c.3753C>T	c.(3751-3753)gtC>gtT	p.V1251V		NM_005909.3	NP_005900.2	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	1251						microtubule|microtubule associated complex	structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(42)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	104		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		GTGAAAAGGTCAGCCCATCGA	0.502000													15	58					0	0	1	0	0
ASAP3	55616	broad.mit.edu	37	1	23779205	23779205	+	Silent	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr1:23779205C>T	ENST00000336689.3	-	4	452	c.408G>A	c.(406-408)ctG>ctA	p.L136L	ASAP3_ENST00000437606.2_Silent_p.L136L	NM_017707.3	NP_060177.2	Q8TDY4	ASAP3_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH domain 3	136					regulation of ARF GTPase activity	cytoplasm	ARF GTPase activator activity|zinc ion binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|ovary(1)|skin(2)|urinary_tract(1)	24						GACCGTCCCTCAGCTGCCCCT	0.572000													68	281					0	0	1	0	0
KLHL11	55175	broad.mit.edu	37	17	40021244	40021244	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr17:40021244G>A	ENST00000319121.3	-	1	440	c.380C>T	c.(379-381)tCg>tTg	p.S127L		NM_018143.1	NP_060613.1	Q9NVR0	KLH11_HUMAN	kelch-like family member 11	127	BTB.					extracellular region				NS(2)|breast(2)|endometrium(1)|large_intestine(2)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	17		Breast(137;0.00156)				AAACTGGCCCGAGAGCAGGGG	0.677000													9	38					0	0	1	0	0
DNM1	1759	broad.mit.edu	37	9	131008756	131008756	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr9:131008756C>G	ENST00000341179.7	+	16	1847	c.1755C>G	c.(1753-1755)atC>atG	p.I585M	DNM1_ENST00000486160.1_Missense_Mutation_p.I585M|DNM1_ENST00000475805.1_Missense_Mutation_p.I585M|DNM1_ENST00000493925.1_3'UTR|DNM1_ENST00000393594.3_Missense_Mutation_p.I585M|DNM1_ENST00000372923.3_Missense_Mutation_p.I585M	NM_001005336.1	NP_001005336.1	Q05193	DYN1_HUMAN	dynamin 1	585	PH.				receptor-mediated endocytosis	microtubule	GTP binding|GTPase activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(15)|lung(6)|ovary(2)|urinary_tract(2)	32						GCAAGCATATCTTTGCCCTCT	0.557000													4	42					0	0	1	0	0
CEP192	55125	broad.mit.edu	37	18	13057601	13057601	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr18:13057601G>A	ENST00000506447.1	+	20	4206	c.4126G>A	c.(4126-4128)Gag>Aag	p.E1376K	CEP192_ENST00000325971.8_Missense_Mutation_p.E780K|CEP192_ENST00000430049.2_Missense_Mutation_p.E901K	NM_032142.3	NP_115518.3	B7ZMF0	B7ZMF0_HUMAN	centrosomal protein 192kDa	971										NS(1)|breast(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(36)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						CCGAGTGCCCGAGGAGTTGAA	0.502000													12	35					0	0	1	0	0
SMC3	9126	broad.mit.edu	37	10	112343948	112343948	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr10:112343948C>G	ENST00000361804.4	+	13	1225	c.1099C>G	c.(1099-1101)Caa>Gaa	p.Q367E		NM_005445.3	NP_005436.1	Q9UQE7	SMC3_HUMAN	structural maintenance of chromosomes 3	367					cell division|DNA mediated transformation|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic spindle organization|negative regulation of DNA endoreduplication|signal transduction|sister chromatid cohesion	basement membrane|chromatin|chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nuclear matrix|nucleoplasm|spindle pole	ATP binding|dynein binding|microtubule motor activity|protein heterodimerization activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(5)|lung(13)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	39		Breast(234;0.0848)|Lung NSC(174;0.238)		Epithelial(162;0.00206)|all cancers(201;0.0227)|BRCA - Breast invasive adenocarcinoma(275;0.127)		TAGATTGGCTCAAGCTACCCA	0.378000													5	50					0	0	1	0	0
SWT1	54823	broad.mit.edu	37	1	185173910	185173910	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr1:185173910C>G	ENST00000367500.4	+	12	1913	c.1748C>G	c.(1747-1749)tCt>tGt	p.S583C	SWT1_ENST00000367501.3_Missense_Mutation_p.S583C	NM_017673.6	NP_060143.4	Q5T5J6	SWT1_HUMAN	SWT1 RNA endoribonuclease homolog (S. cerevisiae)	583										breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(16)|ovary(1)|prostate(1)|urinary_tract(1)	41						AGCATTGTATCTGATCTTGAA	0.343000													19	38					0	0	1	0	0
CCL24	6369	broad.mit.edu	37	7	75441279	75441279	+	Silent	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr7:75441279G>A	ENST00000416943.1	-	4	288	c.195C>T	c.(193-195)ttC>ttT	p.F65F	CCL24_ENST00000222902.2_Silent_p.F65F	NM_002991.2	NP_002982.2	O00175	CCL24_HUMAN	chemokine (C-C motif) ligand 24	65					cell-cell signaling|chemotaxis|immune response|inflammatory response|positive regulation of actin filament polymerization|positive regulation of cell migration|positive regulation of endothelial cell proliferation|positive regulation of Rac GTPase activity|signal transduction	extracellular space	chemokine activity			endometrium(1)|lung(2)	3						TCTTGGTGGTGAAGCTGTGGA	0.592000													10	58					0	0	1	0	0
NSMCE4A	54780	broad.mit.edu	37	10	123727232	123727232	+	Silent	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr10:123727232G>A	ENST00000538652.1	-	4	751	c.114C>T	c.(112-114)tcC>tcT	p.S38S	NSMCE4A_ENST00000369017.5_Silent_p.S197S|NSMCE4A_ENST00000369023.3_Silent_p.S197S|NSMCE4A_ENST00000489266.1_5'UTR			Q9NXX6	NSE4A_HUMAN	non-SMC element 4 homolog A (S. cerevisiae)	197										breast(2)|endometrium(1)|large_intestine(1)|lung(1)|prostate(1)	6		all_neural(114;0.138)|Glioma(114;0.222)				TTATCTTCCAGGAGTCATAGA	0.363000													20	74					0	0	1	0	0
ZNF331	55422	broad.mit.edu	37	19	54080760	54080760	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr19:54080760C>G	ENST00000253144.9	+	7	2279	c.946C>G	c.(946-948)Cag>Gag	p.Q316E	ZNF331_ENST00000513999.1_Missense_Mutation_p.Q316E|ZNF331_ENST00000449416.1_Missense_Mutation_p.Q316E|ZNF331_ENST00000411977.2_Missense_Mutation_p.Q316E|ZNF331_ENST00000511154.1_Missense_Mutation_p.Q316E|ZNF331_ENST00000513265.1_3'UTR|ZNF331_ENST00000511593.2_Missense_Mutation_p.Q316E|ZNF331_ENST00000512387.1_Missense_Mutation_p.Q316E	NM_001253801.1|NM_018555.5	NP_001240730.1|NP_061025.5	Q9NQX6	ZN331_HUMAN	zinc finger protein 331	316					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|large_intestine(1)|lung(1)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	10				GBM - Glioblastoma multiforme(134;0.00555)		TTACCTTACTCAGCATCAGAA	0.478000			T	?	follicular thyroid adenoma								21	73					0	0	1	0	0
SNX19	399979	broad.mit.edu	37	11	130781546	130781546	+	Translation_Start_Site	SNP	G	G	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr11:130781546G>C	ENST00000530356.1	-	0	348				SNX19_ENST00000539184.1_Missense_Mutation_p.L42V|SNX19_ENST00000533318.1_5'UTR|SNX19_ENST00000265909.4_Missense_Mutation_p.L599V|SNX19_ENST00000528555.1_De_novo_Start_OutOfFrame|SNX19_ENST00000533214.1_Missense_Mutation_p.L599V			Q92543	SNX19_HUMAN	sorting nexin 19						cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(8)|ovary(3)|prostate(1)|skin(6)|urinary_tract(1)	35	all_hematologic(175;0.0597)	Lung NSC(97;0.000272)|all_lung(97;0.000608)|Breast(109;0.000962)|all_neural(223;0.0298)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;0.0195)|Lung(977;0.233)		AACTTTCGTAGATCTGGTTTC	0.547000													4	46					0	0	1	0	0
ABHD6	57406	broad.mit.edu	37	3	58270845	58270845	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr3:58270845C>T	ENST00000478253.1	+	8	1216	c.715C>T	c.(715-717)Cat>Tat	p.H239Y	ABHD6_ENST00000295962.4_Missense_Mutation_p.H239Y			Q9BV23	ABHD6_HUMAN	abhydrolase domain containing 6	239						integral to membrane	acylglycerol lipase activity			NS(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|prostate(1)|skin(1)	16				BRCA - Breast invasive adenocarcinoma(55;0.000225)|KIRC - Kidney renal clear cell carcinoma(284;0.0471)|Kidney(284;0.0589)|OV - Ovarian serous cystadenocarcinoma(275;0.209)		CCGCATCCCTCATAACAACTT	0.433000													7	68					0	0	1	0	0
PORCN	64840	broad.mit.edu	37	X	48368320	48368320	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chrX:48368320G>A	ENST00000359882.4	+	2	291	c.112G>A	c.(112-114)Gcc>Acc	p.A38T	PORCN_ENST00000355092.3_Missense_Mutation_p.A38T|PORCN_ENST00000537758.1_Missense_Mutation_p.A38T|PORCN_ENST00000361988.3_Missense_Mutation_p.A38T|PORCN_ENST00000326194.6_Missense_Mutation_p.A38T|PORCN_ENST00000355961.4_Missense_Mutation_p.A38T|PORCN_ENST00000367574.4_5'UTR|PORCN_ENST00000486272.1_3'UTR			Q9H237	PORCN_HUMAN	porcupine homolog (Drosophila)	38	Leu-rich.				Wnt receptor signaling pathway	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						CATCTGCCTCGCCTGCCGCCT	0.597000													15	13					0	0	1	0	0
CPT2	1376	broad.mit.edu	37	1	53676293	53676293	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr1:53676293G>A	ENST00000371486.3	+	4	1462	c.947G>A	c.(946-948)aGg>aAg	p.R316K	RP5-1024G6.2_ENST00000452466.1_RNA	NM_000098.2	NP_000089.1	P23786	CPT2_HUMAN	carnitine palmitoyltransferase 2	316					carnitine shuttle|fatty acid beta-oxidation|regulation of fatty acid oxidation	mitochondrial inner membrane	carnitine O-palmitoyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	15					L-Carnitine(DB00583)|Perhexiline(DB01074)	GAGAGCCTGAGGAAAGTGGAC	0.547000													28	90					0	0	1	0	0
FAT1	2195	broad.mit.edu	37	4	187521167	187521167	+	Silent	SNP	A	A	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr4:187521167A>G	ENST00000441802.2	-	22	12197	c.11988T>C	c.(11986-11988)taT>taC	p.Y3996Y		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	3996	Laminin G-like.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						CGATGTGTGCATAGCTTCTGG	0.507000										HNSCC(5;0.00058)			26	87					0	0	1	0	0
TRPC3	7222	broad.mit.edu	37	4	122828590	122828590	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr4:122828590G>C	ENST00000264811.5	-	6	2124	c.1706C>G	c.(1705-1707)tCt>tGt	p.S569C	TRPC3_ENST00000513531.1_Missense_Mutation_p.S514C|TRPC3_ENST00000379645.3_Missense_Mutation_p.S642C	NM_003305.2	NP_003296.1	Q13507	TRPC3_HUMAN	transient receptor potential cation channel, subfamily C, member 3	557					axon guidance|phototransduction|platelet activation	integral to plasma membrane	protein binding|store-operated calcium channel activity			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(12)|lung(13)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	51						CCTTCCAAGAGAGATCTGCAG	0.418000													5	162					0	0	1	0	0
LRRC19	64922	broad.mit.edu	37	9	26996311	26996311	+	Nonsense_Mutation	SNP	G	G	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr9:26996311G>C	ENST00000380055.5	-	4	892	c.782C>G	c.(781-783)tCa>tGa	p.S261*	IFT74_ENST00000433700.1_Intron|IFT74_ENST00000443698.1_Intron|IFT74_ENST00000429045.2_Intron|IFT74_ENST00000380062.5_Intron|LRRC19_ENST00000482770.1_5'UTR	NM_022901.2	NP_075052.1	Q9H756	LRC19_HUMAN	leucine rich repeat containing 19	261						integral to membrane				breast(1)|endometrium(2)|kidney(1)|lung(2)	6		all_neural(11;1.81e-09)		Lung(218;1.06e-05)|LUSC - Lung squamous cell carcinoma(38;0.0001)		TATATTACCTGAATTTCTTGT	0.259000													5	20					0	0	1	0	0
DNMT3B	1789	broad.mit.edu	37	20	31387101	31387101	+	Nonsense_Mutation	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr20:31387101C>T	ENST00000328111.2	+	16	2047	c.1726C>T	c.(1726-1728)Cga>Tga	p.R576*	DNMT3B_ENST00000201963.3_Nonsense_Mutation_p.R568*|DNMT3B_ENST00000456297.2_Nonsense_Mutation_p.R480*|DNMT3B_ENST00000443239.3_Nonsense_Mutation_p.R514*|DNMT3B_ENST00000375623.4_3'UTR|DNMT3B_ENST00000348286.2_Nonsense_Mutation_p.R556*|DNMT3B_ENST00000353855.2_Nonsense_Mutation_p.R556*|DNMT3B_ENST00000344505.4_Nonsense_Mutation_p.R556*	NM_006892.3	NP_008823.1	Q9UBC3	DNM3B_HUMAN	DNA (cytosine-5-)-methyltransferase 3 beta	576					negative regulation of histone H3-K9 methylation|positive regulation of gene expression|positive regulation of histone H3-K4 methylation		metal ion binding|protein binding|transcription corepressor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(16)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						GCGGCCCATTCGAGTCCTGTC	0.587000													4	25					0	0	1	0	0
MDGA2	161357	broad.mit.edu	37	14	47342716	47342716	+	Missense_Mutation	SNP	A	A	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr14:47342716A>G	ENST00000426342.1	-	14	2524	c.1778T>C	c.(1777-1779)aTa>aCa	p.I593T	MDGA2_ENST00000357362.3_Missense_Mutation_p.I593T|MDGA2_ENST00000439988.2_Missense_Mutation_p.I822T|MDGA2_ENST00000399222.3_Missense_Mutation_p.I24T|MDGA2_ENST00000399232.2_Missense_Mutation_p.I891T	NM_182830.3	NP_878250.2	Q7Z553	MDGA2_HUMAN	MAM domain containing glycosylphosphatidylinositol anchor 2	822	Ig-like 6.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane		p.I593R(2)|p.I891R(1)		breast(3)|endometrium(4)|kidney(2)|large_intestine(14)|lung(41)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(5)	76						TTTGGGAGCTATGCTGAAAAC	0.383000													25	79					0	0	1	0	0
PBK	55872	broad.mit.edu	37	8	27678199	27678199	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr8:27678199C>T	ENST00000301905.4	-	6	941	c.478G>A	c.(478-480)Gaa>Aaa	p.E160K	PBK_ENST00000522944.1_Missense_Mutation_p.E160K	NM_018492.2	NP_060962.2	Q96KB5	TOPK_HUMAN	PDZ binding kinase	160	Protein kinase.				mitosis		ATP binding|protein binding|protein serine/threonine kinase activity			endometrium(1)|large_intestine(2)|lung(1)	4		Ovarian(32;0.000953)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0213)|KIRC - Kidney renal clear cell carcinoma(542;0.101)|Kidney(114;0.121)|Colorectal(74;0.141)		AGTTTCTTTTCTTGGTGCAGA	0.303000													7	35					0	0	1	0	0
ERBB3	2065	broad.mit.edu	37	12	56493802	56493802	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr12:56493802C>T	ENST00000267101.3	+	25	3558	c.3118C>T	c.(3118-3120)Cgg>Tgg	p.R1040W	ERBB3_ENST00000415288.2_Missense_Mutation_p.R981W|ERBB3_ENST00000450146.2_Missense_Mutation_p.R397W|ERBB3_ENST00000553131.1_Missense_Mutation_p.R281W|ERBB3_ENST00000549832.1_Missense_Mutation_p.R160W	NM_001982.3	NP_001973.2	P21860	ERBB3_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3	1040					cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(2)|lung(3)|ovary(1)|skin(1)|stomach(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			AACACTTAATCGGCCACGTGG	0.527000													26	110					0	0	1	0	0
GRIK2	2898	broad.mit.edu	37	6	102124560	102124560	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr6:102124560C>T	ENST00000369138.1	+	4	1094	c.604C>T	c.(604-606)Cgt>Tgt	p.R202C	GRIK2_ENST00000369134.4_Missense_Mutation_p.R153C|GRIK2_ENST00000413795.1_Missense_Mutation_p.R202C|GRIK2_ENST00000421544.1_Missense_Mutation_p.R202C|GRIK2_ENST00000318991.6_Missense_Mutation_p.R202C|GRIK2_ENST00000358361.3_Missense_Mutation_p.R202C|GRIK2_ENST00000369137.3_Missense_Mutation_p.R202C	NM_001166247.1	NP_001159719.1	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	202					glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity	p.R202C(4)		NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	ACTCAAAATTCGTCAGTTACC	0.343000													7	26					0	0	1	0	0
HAS2	3037	broad.mit.edu	37	8	122629412	122629412	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr8:122629412G>A	ENST00000303924.4	-	3	1199	c.662C>T	c.(661-663)tCa>tTa	p.S221L		NM_005328.2	NP_005319.1	Q92819	HAS2_HUMAN	hyaluronan synthase 2	221						integral to plasma membrane	hyaluronan synthase activity		HAS2/PLAG1(10)	breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|lung(19)|ovary(5)|skin(1)	38	Lung NSC(37;3.12e-08)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)|all_neural(195;0.142)		STAD - Stomach adenocarcinoma(47;0.00503)			CTCCACAGATGAGGCTGGGTC	0.398000													11	32					0	0	1	0	0
PPIP5K2	23262	broad.mit.edu	37	5	102482338	102482338	+	Missense_Mutation	SNP	T	T	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr5:102482338T>C	ENST00000321521.9	+	6	1168	c.595T>C	c.(595-597)Tat>Cat	p.Y199H	PPIP5K2_ENST00000358359.3_Missense_Mutation_p.Y199H|PPIP5K2_ENST00000414217.1_Missense_Mutation_p.Y199H|PPIP5K2_ENST00000513500.1_3'UTR			O43314	VIP2_HUMAN	diphosphoinositol pentakisphosphate kinase 2	199					inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	42						TGTTTACATTTATTACCCAAC	0.368000													6	49					0	0	1	0	0
EPB41L5	57669	broad.mit.edu	37	2	120932482	120932482	+	Silent	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr2:120932482G>A	ENST00000263713.5	+	25	2415	c.2201G>A	c.(2200-2202)tGa>tAa	p.*734*	EPB41L5_ENST00000452780.1_Silent_p.*733*|AC012363.4_ENST00000455707.1_RNA|EPB41L5_ENST00000443902.2_3'UTR	NM_020909.3	NP_065960.2	Q9HCM4	E41L5_HUMAN	erythrocyte membrane protein band 4.1 like 5	0						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(5)|lung(12)|ovary(1)	26						ACTGAGCTCTGAGGGCCTGTA	0.488000													28	93					0	0	1	0	0
RARG	5916	broad.mit.edu	37	12	53607396	53607396	+	Missense_Mutation	SNP	T	T	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr12:53607396T>C	ENST00000425354.2	-	8	1389	c.902A>G	c.(901-903)aAt>aGt	p.N301S	RARG_ENST00000394426.1_Missense_Mutation_p.N301S|RARG_ENST00000338561.5_Missense_Mutation_p.N290S|RARG_ENST00000327550.3_Missense_Mutation_p.N229S|RARG_ENST00000543726.1_Missense_Mutation_p.N279S|RARG_ENST00000543762.1_5'UTR	NM_000966.5	NP_000957.1	P13631	RARG_HUMAN	retinoic acid receptor, gamma	301	Ligand-binding.				canonical Wnt receptor signaling pathway|embryonic eye morphogenesis|embryonic hindlimb morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|regulation of cell size|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid	integral to membrane|transcription factor complex	retinoic acid receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(6)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	GAAGCCGGCATTGTGCATCTG	0.622000											OREG0021862	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	65					0	0	1	0	0
NOL4	8715	broad.mit.edu	37	18	31523073	31523073	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr18:31523073C>T	ENST00000261592.5	-	9	1795	c.1498G>A	c.(1498-1500)Gag>Aag	p.E500K	NOL4_ENST00000269185.4_Intron|NOL4_ENST00000538587.1_Missense_Mutation_p.E426K|NOL4_ENST00000535384.1_Missense_Mutation_p.E215K|NOL4_ENST00000535475.1_Missense_Mutation_p.E281K|NOL4_ENST00000589544.1_Intron	NM_001198546.1|NM_003787.4	NP_001185475.1|NP_003778.2	O94818	NOL4_HUMAN	nucleolar protein 4	500						nucleolus	RNA binding	p.E500*(1)		NS(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(7)|lung(20)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	51						TTTCTACTCTCACTCTCACAA	0.428000													14	52					0	0	1	0	0
AMOTL1	154810	broad.mit.edu	37	11	94592733	94592733	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr11:94592733C>T	ENST00000433060.2	+	9	2129	c.1988C>T	c.(1987-1989)gCc>gTc	p.A663V	AMOTL1_ENST00000317829.8_Missense_Mutation_p.A613V|AMOTL1_ENST00000317837.9_Intron	NM_130847.2	NP_570899.1	Q8IY63	AMOL1_HUMAN	angiomotin like 1	663						cytoplasm|tight junction	identical protein binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(14)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(2)	36		Acute lymphoblastic leukemia(157;2.38e-05)|all_hematologic(158;0.00824)				GAATACAATGCCCCAGCCCTC	0.527000													5	21					0	0	1	0	0
NEUROD1	4760	broad.mit.edu	37	2	182542615	182542615	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr2:182542615G>A	ENST00000295108.3	-	2	1430	c.973C>T	c.(973-975)Cgc>Tgc	p.R325C	NEUROD1_ENST00000496876.1_Intron|CERKL_ENST00000479558.1_Intron	NM_002500.4	NP_002491.2	Q13562	NDF1_HUMAN	neuronal differentiation 1	325					amacrine cell differentiation|cerebellum development|dentate gyrus development|embryonic organ morphogenesis|enteroendocrine cell differentiation|glucose homeostasis|inner ear development|insulin secretion|negative regulation of apoptosis|nitric oxide mediated signal transduction|positive regulation of apoptosis|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of intestinal epithelial structure maintenance|response to glucose stimulus	cytoplasm|nucleus	chromatin binding|E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding	p.R325C(1)		endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25			OV - Ovarian serous cystadenocarcinoma(117;0.088)			ATCTCGCAGCGAGGGGCAGCG	0.498000													12	82					0	0	1	0	0
HSPG2	3339	broad.mit.edu	37	1	22167727	22167727	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr1:22167727C>T	ENST00000374695.3	-	71	9459	c.9380G>A	c.(9379-9381)gGa>gAa	p.G3127E		NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	3127	Ig-like C2-type 17.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	GACAGCCTTTCCCACTTTCAC	0.652000													14	74					0	0	1	0	0
EIF3B	8662	broad.mit.edu	37	7	2409171	2409171	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr7:2409171C>G	ENST00000360876.4	+	10	1524	c.1468C>G	c.(1468-1470)Cca>Gca	p.P490A	EIF3B_ENST00000397011.2_Missense_Mutation_p.P490A	NM_001037283.1	NP_001032360.1	P55884	EIF3B_HUMAN	eukaryotic translation initiation factor 3, subunit B	490					regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	nucleotide binding|protein complex scaffold|translation initiation factor activity			breast(2)|endometrium(4)|kidney(2)|large_intestine(3)|lung(11)|ovary(1)|skin(1)	24		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0833)|OV - Ovarian serous cystadenocarcinoma(56;7.76e-14)		CAAAGATATTCCAGCCAGGGT	0.483000													48	157					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105410651	105410651	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr14:105410651C>T	ENST00000333244.5	-	7	11256	c.11137G>A	c.(11137-11139)Gag>Aag	p.E3713K	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3713						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CCGGCTCCCTCGGGCACCTGG	0.632000													59	221					0	0	1	0	0
PNKP	11284	broad.mit.edu	37	19	50367447	50367447	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr19:50367447C>T	ENST00000322344.3	-	6	734	c.625G>A	c.(625-627)Gag>Aag	p.E209K	PNKP_ENST00000596014.1_Missense_Mutation_p.E209K|PNKP_ENST00000600910.1_Missense_Mutation_p.E209K|PNKP_ENST00000600573.1_Missense_Mutation_p.E209K	NM_007254.3	NP_009185.2	Q96T60	PNKP_HUMAN	polynucleotide kinase 3'-phosphatase	209					DNA damage response, detection of DNA damage|DNA-dependent DNA replication|nucleotide-excision repair, DNA damage removal|response to oxidative stress|response to radiation	nucleolus	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|damaged DNA binding|double-stranded DNA binding|endonuclease activity|nucleotide kinase activity|polynucleotide 3'-phosphatase activity|protein binding			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(10)|ovary(1)|urinary_tract(1)	19		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0118)|OV - Ovarian serous cystadenocarcinoma(262;0.0134)		TTGTAGCCCTCGGCTTCCAGC	0.642000								Other BER factors					32	45					0	0	1	0	0
WBSCR17	64409	broad.mit.edu	37	7	71135092	71135092	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr7:71135092G>A	ENST00000333538.5	+	8	2036	c.1402G>A	c.(1402-1404)Gag>Aag	p.E468K	WBSCR17_ENST00000498380.2_3'UTR	NM_022479.1	NP_071924.1	Q6IS24	GLTL3_HUMAN	Williams-Beuren syndrome chromosome region 17	468	Ricin B-type lectin.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(5)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(7)|large_intestine(22)|lung(45)|ovary(2)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	100		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				TGCTTACGGGGAGGTAATTCA	0.413000													8	186					0	0	1	0	0
FRZB	2487	broad.mit.edu	37	2	183731003	183731003	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr2:183731003G>A	ENST00000295113.4	-	1	887	c.278C>T	c.(277-279)gCg>gTg	p.A93V		NM_001463.3	NP_001454.2	Q92765	SFRP3_HUMAN	frizzled-related protein	93	FZ.				brain development|cochlea morphogenesis|gonad development|mammary gland involution|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cartilage development|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of hepatocyte differentiation|positive regulation of apoptosis|positive regulation of fat cell differentiation|skeletal system development|vasculature development|Wnt receptor signaling pathway	cytoplasm|extracellular space|membrane	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)	21			OV - Ovarian serous cystadenocarcinoma(117;0.109)|Epithelial(96;0.231)			GCAGATGGGCGCGTACATGGC	0.607000													33	42					0	0	1	0	0
PIBF1	10464	broad.mit.edu	37	13	73401164	73401164	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr13:73401164G>A	ENST00000326291.6	+	7	1161	c.823G>A	c.(823-825)Gaa>Aaa	p.E275K		NM_006346.2	NP_006337.2	Q8WXW3	PIBF1_HUMAN	progesterone immunomodulatory binding factor 1	275						centrosome				breast(2)|endometrium(2)|kidney(1)|large_intestine(1)|lung(10)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	24		Prostate(6;0.00191)|Breast(118;0.0736)|Acute lymphoblastic leukemia(28;0.0865)		GBM - Glioblastoma multiforme(99;0.000664)		TGATGCACTTGAACAGGAAGT	0.338000													4	46					0	0	1	0	0
JMJD1C	221037	broad.mit.edu	37	10	64966452	64966452	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr10:64966452C>G	ENST00000399262.2	-	10	5195	c.4977G>C	c.(4975-4977)aaG>aaC	p.K1659N	JMJD1C_ENST00000542921.1_Missense_Mutation_p.K1477N|JMJD1C_ENST00000402544.1_Missense_Mutation_p.K1440N|JMJD1C_ENST00000399251.1_Missense_Mutation_p.K1440N	NM_032776.1	NP_116165.1	Q15652	JHD2C_HUMAN	jumonji domain containing 1C	1659					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(8)|large_intestine(9)|lung(27)|ovary(6)|prostate(4)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	77	Prostate(12;0.0119)|all_hematologic(501;0.191)					CACCTTTTCTCTTTTGCAAAT	0.373000													19	49					0	0	1	0	0
PIAS2	9063	broad.mit.edu	37	18	44424064	44424064	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr18:44424064C>G	ENST00000585916.1	-	8	993	c.994G>C	c.(994-996)Gat>Cat	p.D332H	PIAS2_ENST00000545673.1_Missense_Mutation_p.D42H|PIAS2_ENST00000324794.7_Missense_Mutation_p.D332H	NM_004671.3	NP_004662.2	O75928	PIAS2_HUMAN	protein inhibitor of activated STAT, 2	332					androgen receptor signaling pathway|negative regulation of androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck|PML body	androgen receptor binding|DNA binding|protein binding|SUMO ligase activity|transcription coactivator activity|zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(8)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	22						ATTTCACTATCAGGATCTGCA	0.279000													20	69					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135496474	135496474	+	Missense_Mutation	SNP	A	A	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chrX:135496474A>C	ENST00000394143.1	+	25	9484	c.9193A>C	c.(9193-9195)Agc>Cgc	p.S3065R	GPR112_ENST00000394141.1_Missense_Mutation_p.S2860R|GPR112_ENST00000287534.4_Missense_Mutation_p.S2784R|GPR112_ENST00000370652.1_Missense_Mutation_p.S3065R|GPR112_ENST00000412101.1_Missense_Mutation_p.S2860R	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	3065					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					TTCAGAAATAAGCTTTCCAAA	0.388000													29	49					0	0	1	0	0
DDX31	64794	broad.mit.edu	37	9	135470375	135470375	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr9:135470375C>G	ENST00000372159.3	-	20	2585	c.2434G>C	c.(2434-2436)Ggt>Cgt	p.G812R	DDX31_ENST00000372153.1_Missense_Mutation_p.G739R|DDX31_ENST00000438527.3_Missense_Mutation_p.G683R	NM_022779.7	NP_073616.6	Q9H8H2	DDX31_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 31	812						nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(4)|lung(10)|prostate(1)|skin(1)|urinary_tract(1)	27				OV - Ovarian serous cystadenocarcinoma(145;2.67e-06)|Epithelial(140;7.61e-05)		GGCCGGCCACCAGGCTCTCCA	0.547000													35	145					0	0	1	0	0
UNC5B	219699	broad.mit.edu	37	10	73050782	73050782	+	Missense_Mutation	SNP	C	C	T	rs139601435		TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr10:73050782C>T	ENST00000335350.6	+	9	1626	c.1210C>T	c.(1210-1212)Cgt>Tgt	p.R404C	UNC5B_ENST00000373192.4_Missense_Mutation_p.R393C	NM_170744.4	NP_734465.2	Q8IZJ1	UNC5B_HUMAN	unc-5 homolog B (C. elegans)	404					apoptosis|axon guidance|regulation of apoptosis	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|prostate(4)|skin(4)	49						CCGCAACTGCCGTGACTTCGA	0.607000													62	229					0	0	1	0	0
KRT6A	3853	broad.mit.edu	37	12	52885413	52885413	+	Silent	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr12:52885413C>T	ENST00000330722.6	-	2	716	c.648G>A	c.(646-648)caG>caA	p.Q216Q		NM_005554.3	NP_005545.1	P02538	K2C6A_HUMAN	keratin 6A	216	Linker 1.|Rod.				cell differentiation|ectoderm development|positive regulation of cell proliferation	keratin filament	protein binding|structural constituent of cytoskeleton			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|liver(1)|lung(14)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	39				BRCA - Breast invasive adenocarcinoma(357;0.189)		TGTTGATGTACTGCTCGAACA	0.587000													4	124					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9056550	9056550	+	Nonsense_Mutation	SNP	G	G	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr19:9056550G>C	ENST00000397910.4	-	3	31099	c.30896C>G	c.(30895-30897)tCa>tGa	p.S10299*		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	10301	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						ACCTGAACCTGAGATGGCTCG	0.532000													16	85					0	0	1	0	0
LOC220729	220729	broad.mit.edu	37	3	197348674	197348674	+	RNA	SNP	A	A	G	rs144273946	by1000genomes	TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr3:197348674A>G	ENST00000418868.1	-	0	585					NR_003266.2																						GGCTCTGTCCACCAAATGCAC	0.478000													4	102					0	0	1	0	0
POLR2L	5441	broad.mit.edu	37	11	842418	842418	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr11:842418C>G	ENST00000322028.4	-	1	127	c.91G>C	c.(91-93)Gag>Cag	p.E31Q		NM_021128.4	NP_066951.1	P62875	RPAB5_HUMAN	polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa	31					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription from RNA polymerase I promoter|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase II promoter|transcription elongation from RNA polymerase III promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|zinc ion binding			lung(1)	1		all_cancers(49;2.31e-08)|all_epithelial(84;3.72e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.179)|all_lung(207;0.227)		all cancers(45;4.1e-25)|Epithelial(43;3.15e-24)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		cctcaccccTCGGTGTACTCG	0.731000													7	14					0	0	1	0	0
ERBB3	2065	broad.mit.edu	37	12	56494849	56494849	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr12:56494849C>G	ENST00000267101.3	+	27	3646	c.3206C>G	c.(3205-3207)tCt>tGt	p.S1069C	ERBB3_ENST00000415288.2_Missense_Mutation_p.S1010C|ERBB3_ENST00000450146.2_Missense_Mutation_p.S426C|ERBB3_ENST00000553131.1_Missense_Mutation_p.S310C|ERBB3_ENST00000549832.1_Missense_Mutation_p.S189C	NM_001982.3	NP_001973.2	P21860	ERBB3_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3	1069					cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(2)|lung(3)|ovary(1)|skin(1)|stomach(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			CCTTAGGAGTCTGCAGTTTCT	0.463000													6	23					0	0	1	0	0
PDZD3	79849	broad.mit.edu	37	11	119057090	119057090	+	Silent	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr11:119057090C>T	ENST00000531114.1	+	2	768	c.219C>T	c.(217-219)agC>agT	p.S73S	PDZD3_ENST00000525131.1_Intron|PDZD3_ENST00000392817.2_Silent_p.S73S|PDZD3_ENST00000355547.5_Intron|PDZD3_ENST00000322712.4_Intron			Q86UT5	NHRF4_HUMAN	PDZ domain containing 3	73					cGMP-mediated signaling|ion transport|negative regulation of cGMP biosynthetic process|response to toxin|water transport	apical part of cell|brush border|cytosol|membrane fraction|subapical complex	guanylate cyclase inhibitor activity|ion channel inhibitor activity|protein C-terminus binding			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(1)|lung(4)|ovary(1)	14	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0523)|Breast(348;0.174)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;7.52e-05)		AACTGCCCAGCACCCTATCAG	0.617000													6	27					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128496974	128496974	+	Splice_Site	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr7:128496974C>T	ENST00000325888.8	+	45	7821	c.7561_splice	c.e45+1	p.T2520_splice	RP11-309L24.2_ENST00000469965.1_RNA|FLNC_ENST00000346177.6_Splice_Site_p.T2487_splice	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	2520	Interaction with INPPL1.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						GAGGCACTACCGGTGAGTGCC	0.637000													10	20					0	0	1	0	0
HIST1H4F	8361	broad.mit.edu	37	6	26240845	26240845	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr6:26240845G>C	ENST00000377745.2	+	1	285	c.192G>C	c.(190-192)gaG>gaC	p.E64D		NM_003540.3	NP_003531.1	P62805	H4_HUMAN	histone cluster 1, H4f	64			E -> Q (in a breast cancer sample; somatic mutation).		CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			cervix(1)|endometrium(1)|large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)	5		all_hematologic(11;0.0945)|Acute lymphoblastic leukemia(11;0.167)				TGTTCCTGGAGAATGTGATAC	0.597000													14	49					0	0	1	0	0
PFN2	5217	broad.mit.edu	37	3	149686274	149686274	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr3:149686274G>C	ENST00000239940.7	-	2	448	c.196C>G	c.(196-198)Ctt>Gtt	p.L66V	PFN2_ENST00000498307.1_Missense_Mutation_p.L17V|PFN2_ENST00000497148.1_Missense_Mutation_p.L17V|PFN2_ENST00000475518.1_Missense_Mutation_p.L17V|PFN2_ENST00000494827.1_Missense_Mutation_p.L17V|PFN2_ENST00000481767.1_Missense_Mutation_p.L17V|PFN2_ENST00000452853.2_Missense_Mutation_p.L66V|PFN2_ENST00000481275.1_Missense_Mutation_p.L17V|PFN2_ENST00000423691.2_Missense_Mutation_p.L66V|PFN2_ENST00000461868.1_Missense_Mutation_p.L66V|PFN2_ENST00000490975.1_Missense_Mutation_p.L66V|PFN2_ENST00000461930.1_3'UTR|PFN2_ENST00000489155.1_Missense_Mutation_p.L17V			P35080	PROF2_HUMAN	profilin 2	66					actin cytoskeleton organization|regulation of actin polymerization or depolymerization	actin cytoskeleton|cytoplasm	actin binding|phosphatidylinositol-4,5-bisphosphate binding			large_intestine(1)|lung(4)|ovary(1)|prostate(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			TTCGCGCCAAGAGTCAAACCG	0.443000													37	222					0	0	1	0	0
HIST1H2BN	8341	broad.mit.edu	37	6	27806606	27806606	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr6:27806606C>T	ENST00000606613.1	+	1	228	c.167C>T	c.(166-168)tCg>tTg	p.S56L	HIST1H2BN_ENST00000396980.3_Missense_Mutation_p.S56L			Q99877	H2B1N_HUMAN	histone cluster 1, H2bn	56					nucleosome assembly	nucleosome|nucleus	DNA binding			central_nervous_system(1)|endometrium(3)|lung(3)|prostate(1)	8						ACCGGTATCTCGTCCAAGGCC	0.597000													78	247					0	0	1	0	0
ABCA6	23460	broad.mit.edu	37	17	67108383	67108383	+	Silent	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr17:67108383C>G	ENST00000284425.2	-	16	2247	c.2073G>C	c.(2071-2073)ctG>ctC	p.L691L		NM_080284.2	NP_525023.2	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 6	691	ABC transporter 1.				transport	integral to membrane	ATP binding|ATPase activity			breast(6)|endometrium(5)|kidney(17)|large_intestine(18)|lung(20)|ovary(3)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	82	Breast(10;5.65e-12)					CTGCACACTTCAGTCTCCCAT	0.373000													36	100					0	0	1	0	0
BCRP7	100133163	broad.mit.edu	37	22	18845939	18845939	+	RNA	SNP	G	G	A	rs117961252	by1000genomes	TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr22:18845939G>A	ENST00000412938.1	+	0	3297																											TGCCTGGGCCGTGGAGCACTC	0.483000													3	23					0	0	1	0	0
TPP2	7174	broad.mit.edu	37	13	103297012	103297012	+	Nonsense_Mutation	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr13:103297012C>T	ENST00000376052.3	+	18	2297	c.2281C>T	c.(2281-2283)Cag>Tag	p.Q761*	TPP2_ENST00000376065.4_Nonsense_Mutation_p.Q761*			P29144	TPP2_HUMAN	tripeptidyl peptidase II	761					proteolysis	cytoplasm|nucleus	aminopeptidase activity|serine-type endopeptidase activity|tripeptidyl-peptidase activity			breast(2)|endometrium(5)|kidney(2)|large_intestine(12)|lung(21)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	52	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TACTGCTCCTCAGTTAAACAT	0.343000													5	40					0	0	1	0	0
KRT222	125113	broad.mit.edu	37	17	38816365	38816365	+	Missense_Mutation	SNP	T	T	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr17:38816365T>A	ENST00000476049.1	-	3	361	c.320A>T	c.(319-321)gAg>gTg	p.E107V	KRT222_ENST00000394052.3_Missense_Mutation_p.E107V			Q8N1A0	KT222_HUMAN	keratin 222	107						intermediate filament	structural molecule activity			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)|prostate(2)|skin(1)	15						TTCCTGTAGCTCTTTTTCTAG	0.483000													24	87					0	0	1	0	0
ARHGAP39	80728	broad.mit.edu	37	8	145756245	145756245	+	Silent	SNP	C	C	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr8:145756245C>A	ENST00000276826.5	-	9	3099	c.2898G>T	c.(2896-2898)ctG>ctT	p.L966L	ARHGAP39_ENST00000540274.1_Silent_p.L966L|ARHGAP39_ENST00000377307.2_Silent_p.L997L			Q9C0H5	RHG39_HUMAN	Rho GTPase activating protein 39	966	Rho-GAP.				axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|nucleus	GTPase activator activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	22						ACCACAGCTTCAGCAGGGACG	0.706000													14	24					2.61681e-11	2.80624e-11	1	1	0
FOXC1	2296	broad.mit.edu	37	6	1610983	1610983	+	Silent	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr6:1610983G>A	ENST00000380874.2	+	1	303	c.303G>A	c.(301-303)ctG>ctA	p.L101L		NM_001453.2	NP_001444.2	Q12948	FOXC1_HUMAN	forkhead box C1	101				L -> Q (in Ref. 5; AAK13575).	anti-apoptosis|artery morphogenesis|blood vessel remodeling|brain development|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|germ cell migration|glycosaminoglycan metabolic process|lacrimal gland development|lymphangiogenesis|metanephros development|negative regulation of mitotic cell cycle|neural crest cell fate commitment|Notch signaling pathway|odontogenesis of dentine-containing tooth|ossification|ovarian follicle development|paraxial mesodermal cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|regulation of blood vessel size|regulation of organ growth|regulation of sequence-specific DNA binding transcription factor activity|somitogenesis|ureteric bud development|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	nuclear heterochromatin|transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(1)	8	Ovarian(93;0.0733)	all_cancers(2;4.45e-07)|all_epithelial(2;4.33e-05)|all_lung(73;0.0713)|all_hematologic(90;0.0895)		Epithelial(2;0.0904)|OV - Ovarian serous cystadenocarcinoma(45;0.095)|all cancers(2;0.168)		AGATCACCCTGAACGGCATCT	0.597000													31	174					0	0	1	0	0
FSIP2	401024	broad.mit.edu	37	2	186670114	186670114	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr2:186670114G>C	ENST00000343098.5	+	17	16348	c.16348G>C	c.(16348-16350)Gaa>Caa	p.E5450Q	FSIP2_ENST00000424728.1_Missense_Mutation_p.E5361Q	NM_173651.2	NP_775922.2			fibrous sheath interacting protein 2											NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(11)|lung(46)|pancreas(1)|urinary_tract(2)	69						ACAGTTCATAGAAAAATGCAC	0.313000													4	70					0	0	1	0	0
IGHV3-35	28432	broad.mit.edu	37	14	106845429	106845429	+	RNA	SNP	G	G	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr14:106845429G>C	ENST00000390617.2	-	0	259																											GCCCTTCACAGAGTCTGCATA	0.522000													52	172					0	0	1	0	0
NEK5	341676	broad.mit.edu	37	13	52676138	52676138	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr13:52676138C>G	ENST00000355568.4	-	11	962	c.823G>C	c.(823-825)Gaa>Caa	p.E275Q		NM_199289.1	NP_954983.1	Q6P3R8	NEK5_HUMAN	NIMA-related kinase 5	275							ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(8)|lung(11)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	39		Breast(56;0.00173)|Lung NSC(96;0.0168)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;3.7e-08)		TGACTGAATTCTTCCTGAATG	0.468000													10	44					0	0	1	0	0
TIE1	7075	broad.mit.edu	37	1	43772592	43772592	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr1:43772592C>T	ENST00000372476.3	+	4	645	c.566C>T	c.(565-567)tCg>tTg	p.S189L	TIE1_ENST00000441333.2_Missense_Mutation_p.S189L|TIE1_ENST00000538015.1_Missense_Mutation_p.S189L	NM_001253357.1|NM_005424.4	NP_001240286.1|NP_005415.1	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	189					mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(8)|lung(28)|ovary(3)|prostate(2)|salivary_gland(1)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	70	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CAGCCACCATCGAGCGGCATC	0.607000													51	84					0	0	1	0	0
NPM2	10361	broad.mit.edu	37	8	21883270	21883270	+	Nonsense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr8:21883270C>G	ENST00000397940.1	+	4	1272	c.257C>G	c.(256-258)tCa>tGa	p.S86*	NPM2_ENST00000518119.1_Nonsense_Mutation_p.S86*|NPM2_ENST00000381530.5_Nonsense_Mutation_p.S86*|NPM2_ENST00000521157.1_Nonsense_Mutation_p.S86*|NPM2_ENST00000289820.6_Nonsense_Mutation_p.S86*|NPM2_ENST00000520180.1_3'UTR			Q86SE8	NPM2_HUMAN	nucleophosmin/nucleoplasmin 2	86					chromatin remodeling|embryo development|oocyte differentiation|positive regulation of meiosis|regulation of exit from mitosis|single fertilization	cytoplasmic chromatin|nuclear chromatin	histone binding|nucleic acid binding			large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	4				Colorectal(74;8.48e-05)|READ - Rectum adenocarcinoma(5;0.0276)|COAD - Colon adenocarcinoma(73;0.0618)		CTCCAGGCCTCAGTCCTCCCC	0.597000													63	173					0	0	1	0	0
SH3RF1	57630	broad.mit.edu	37	4	170077719	170077719	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr4:170077719C>G	ENST00000284637.9	-	3	846	c.505G>C	c.(505-507)Gaa>Caa	p.E169Q	SH3RF1_ENST00000508685.1_5'UTR	NM_020870.3	NP_065921.2	Q7Z6J0	SH3R1_HUMAN	SH3 domain containing ring finger 1	169	SH3 1.					Golgi apparatus|lamellipodium|perinuclear region of cytoplasm	ligase activity|zinc ion binding			NS(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(10)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	31		Prostate(90;0.00267)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)		TACCAATTTTCATCCACTTGT	0.433000													23	105					0	0	1	0	0
HM13	81502	broad.mit.edu	37	20	30154072	30154072	+	Silent	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr20:30154072C>G	ENST00000335574.5	+	11	1132	c.1008C>G	c.(1006-1008)gcC>gcG	p.A336A	HM13_ENST00000340852.5_Silent_p.A336A|HM13_ENST00000398174.3_Silent_p.A336A|HM13_ENST00000492709.1_3'UTR|HM13_ENST00000376127.3_Silent_p.A294A	NM_178580.1	NP_848695.1	Q8TCT9	HM13_HUMAN	histocompatibility (minor) 13	336					membrane protein proteolysis	cell surface|endoplasmic reticulum membrane|integral to membrane|plasma membrane	aspartic-type endopeptidase activity|protein binding			breast(1)|endometrium(2)|large_intestine(2)|lung(4)|prostate(1)|skin(1)|urinary_tract(1)	12	all_cancers(5;3.44e-05)|Lung NSC(7;4.38e-06)|all_lung(7;7.65e-06)|all_hematologic(12;0.158)|Ovarian(7;0.198)		all cancers(5;0.000479)|Colorectal(19;0.00202)|COAD - Colon adenocarcinoma(19;0.0264)			TGGCGCTGGCCAAGGGAGAAG	0.617000													9	41					0	0	1	0	0
ARGFX	503582	broad.mit.edu	37	3	121305090	121305090	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr3:121305090G>C	ENST00000334384.3	+	4	601	c.591G>C	c.(589-591)gaG>gaC	p.E197D		NM_001012659.1	NP_001012677.1	A6NJG6	ARGFX_HUMAN	arginine-fifty homeobox	197						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.E197D(1)		kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	15				GBM - Glioblastoma multiforme(114;0.152)		CCTTCACTGAGAGTTCTACCA	0.468000													38	169					0	0	1	0	0
UFSP2	55325	broad.mit.edu	37	4	186339890	186339890	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr4:186339890C>G	ENST00000264689.6	-	3	233	c.117G>C	c.(115-117)ttG>ttC	p.L39F	UFSP2_ENST00000502282.1_5'UTR	NM_018359.3	NP_060829.2	Q9NUQ7	UFSP2_HUMAN	UFM1-specific peptidase 2	39						endoplasmic reticulum|nucleus	small conjugating protein-specific protease activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	12		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;0.00109)|Colorectal(36;0.0215)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;3.4e-25)|Epithelial(43;2.23e-22)|OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;8.1e-05)|GBM - Glioblastoma multiforme(59;0.000148)|STAD - Stomach adenocarcinoma(60;0.000782)|LUSC - Lung squamous cell carcinoma(40;0.00939)|COAD - Colon adenocarcinoma(29;0.0108)|READ - Rectum adenocarcinoma(43;0.166)		ACAGGTCACTCAACACATGTT	0.348000													10	41					0	0	1	0	0
SLC46A1	113235	broad.mit.edu	37	17	26726681	26726681	+	Silent	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr17:26726681C>T	ENST00000440501.1	-	6	1466	c.1371G>A	c.(1369-1371)caG>caA	p.Q457Q	SLC46A1_ENST00000321666.5_Silent_p.Q428Q|SLC46A1_ENST00000584729.1_5'UTR|SARM1_ENST00000457710.3_3'UTR	NM_080669.4	NP_542400.2	Q96NT5	PCFT_HUMAN	solute carrier family 46 (folate transporter), member 1	457					cellular iron ion homeostasis|folic acid metabolic process	apical plasma membrane|cytoplasm|integral to membrane	folic acid binding|folic acid transporter activity|heme transporter activity			lung(5)	5	all_lung(13;0.000533)|Lung NSC(42;0.00171)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)	Folic Acid(DB00158)	ATCAGGGGCTCTGGGGAAACT	0.562000													9	30					0	0	1	0	0
ZKSCAN4	387032	broad.mit.edu	37	6	28219640	28219640	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr6:28219640C>G	ENST00000377294.2	-	1	362	c.119G>C	c.(118-120)aGa>aCa	p.R40T	ZKSCAN4_ENST00000423974.2_Intron	NM_019110.3	NP_061983.2	Q969J2	ZKSC4_HUMAN	zinc finger with KRAB and SCAN domains 4	40					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|large_intestine(2)|lung(10)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	18						GCAGGGTGCTCTCACCTCCGC	0.701000													5	74					0	0	1	0	0
KIAA2018	205717	broad.mit.edu	37	3	113374459	113374459	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr3:113374459G>A	ENST00000316407.4	-	7	6480	c.6070C>T	c.(6070-6072)Ctt>Ttt	p.L2024F	KIAA2018_ENST00000491165.1_Intron|KIAA2018_ENST00000478658.1_Missense_Mutation_p.L2024F	NM_001009899.2	NP_001009899.2	Q68DE3	K2018_HUMAN	KIAA2018	2024					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			NS(1)|breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|liver(1)|lung(30)|ovary(8)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	80						TGACGTCCAAGAATCATACTG	0.463000													12	72					0	0	1	0	0
KIF4B	285643	broad.mit.edu	37	5	154395085	154395085	+	Missense_Mutation	SNP	C	C	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr5:154395085C>A	ENST00000435029.4	+	1	1826	c.1666C>A	c.(1666-1668)Caa>Aaa	p.Q556K		NM_001099293.1	NP_001092763.1	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	556					axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(27)|ovary(2)|upper_aerodigestive_tract(1)	58	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			CATTCAGTTTCAATACCAGGA	0.403000													20	35					8.34094e-07	8.66591e-07	1	1	0
RAB31	11031	broad.mit.edu	37	18	9859311	9859311	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr18:9859311C>T	ENST00000578921.1	+	7	818	c.577C>T	c.(577-579)Cgg>Tgg	p.R193W	RAB31_ENST00000577284.1_3'UTR	NM_006868.3	NP_006859.2	Q13636	RAB31_HUMAN	RAB31, member RAS oncogene family	192					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			breast(2)|endometrium(2)|large_intestine(2)|lung(3)|skin(1)	10						AGCCAGCCGCCGGTGCTGTTG	0.577000													7	46					0	0	1	0	0
LPAR2	9170	broad.mit.edu	37	19	19737862	19737862	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr19:19737862C>G	ENST00000542587.1	-	5	1134	c.232G>C	c.(232-234)Gac>Cac	p.D78H	LPAR2_ENST00000407877.3_Missense_Mutation_p.D78H|LPAR2_ENST00000586703.1_Missense_Mutation_p.D78H			Q9HBW0	LPAR2_HUMAN	lysophosphatidic acid receptor 2	78					activation of phospholipase C activity|elevation of cytosolic calcium ion concentration	cell surface|integral to plasma membrane	LIM domain binding|lipid binding			breast(1)|endometrium(2)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|urinary_tract(1)	10						GCGAAGAGGTCAGCCGCGGCC	0.632000													6	33					0	0	1	0	0
CTAGE1	64693	broad.mit.edu	37	18	19995791	19995791	+	Missense_Mutation	SNP	G	G	C			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr18:19995791G>C	ENST00000391403.2	-	1	2087	c.1984C>G	c.(1984-1986)Cct>Gct	p.P662A		NM_172241.2	NP_758441.2	Q96RT6	CTGE2_HUMAN	cutaneous T-cell lymphoma-associated antigen 1	662	Pro-rich.					integral to membrane				cervix(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(19)|ovary(1)	27	all_cancers(21;0.000361)|all_epithelial(16;9.61e-06)|Colorectal(14;0.0533)|Lung NSC(20;0.0605)|Ovarian(2;0.116)|all_lung(20;0.135)					AGAGGTGGAGGAACAAAGCCA	0.473000													32	171					0	0	1	0	0
RASL11A	387496	broad.mit.edu	37	13	27847221	27847221	+	Missense_Mutation	SNP	G	G	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr13:27847221G>A	ENST00000241463.4	+	4	937	c.319G>A	c.(319-321)Gag>Aag	p.E107K	RASL11A_ENST00000480803.1_3'UTR	NM_206827.1	NP_996563.1	Q6T310	RSLBA_HUMAN	RAS-like, family 11, member A	107	Small GTPase-like.				positive regulation of transcription from RNA polymerase I promoter|small GTPase mediated signal transduction|transcription, DNA-dependent	membrane|nucleolus	GTP binding|GTPase activity			breast(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(3)|prostate(1)	10		Lung SC(185;0.0161)	Colorectal(13;0.00042)|READ - Rectum adenocarcinoma(15;0.105)	all cancers(112;0.0173)|GBM - Glioblastoma multiforme(144;0.0557)|OV - Ovarian serous cystadenocarcinoma(117;0.152)|Epithelial(112;0.164)		GCAGTGGGCCGAGGGTTTTCT	0.517000													4	85					0	0	1	0	0
BTAF1	9044	broad.mit.edu	37	10	93773754	93773754	+	Missense_Mutation	SNP	C	C	G			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr10:93773754C>G	ENST00000265990.6	+	32	4860	c.4552C>G	c.(4552-4554)Caa>Gaa	p.Q1518E	BTAF1_ENST00000544642.1_Missense_Mutation_p.Q346E	NM_003972.2	NP_003963.1	O14981	BTAF1_HUMAN	BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa	1518					negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(2)|urinary_tract(6)	59		Colorectal(252;0.0846)				TAAAATTATTCAAGACTATTA	0.383000													18	94					0	0	1	0	0
DENND4B	9909	broad.mit.edu	37	1	153907294	153907294	+	Silent	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr1:153907294C>T	ENST00000361217.4	-	18	3133	c.2715G>A	c.(2713-2715)caG>caA	p.Q905Q		NM_014856.2	NP_055671.2	O75064	DEN4B_HUMAN	DENN/MADD domain containing 4B	905	Gln-rich.									NS(1)|breast(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	36	all_lung(78;2.89e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			gctgctgctgctgctgctgct	0.632000													4	73					0	0	1	0	0
SLC35G6	643664	broad.mit.edu	37	17	7386226	7386226	+	Missense_Mutation	SNP	C	C	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr17:7386226C>T	ENST00000412468.2	+	2	1038	c.923C>T	c.(922-924)tCt>tTt	p.S308F	ZBTB4_ENST00000311403.4_Intron	NM_001102614.1	NP_001096084.1	P0C7Q6	AMCL3_HUMAN	solute carrier family 35, member G6	308	DUF6 2.					integral to membrane											GTGGCACCTTCTGACATCGTG	0.577000													4	163					0	0	1	0	0
FMO2	2327	broad.mit.edu	37	1	171174566	171174567	+	Frame_Shift_Ins	INS	-	-	T			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr1:171174566_171174567insT	ENST00000441535.1	+	7	1093_1094	c.976_977insT	c.(976-978)tttfs	p.F326fs	FMO2_ENST00000529935.1_3'UTR|RP1-127D3.4_ENST00000445290.1_RNA|RP1-127D3.4_ENST00000422841.1_RNA|RP1-45C12.1_ENST00000455124.1_RNA|FMO2_ENST00000209929.7_Frame_Shift_Ins_p.F326fs|RP1-127D3.4_ENST00000445909.1_RNA	NM_001460.2	NP_001451.1	Q99518	FMO2_HUMAN	flavin containing monooxygenase 2 (non-functional)	326					drug metabolic process|NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|host cell microsome|integral to membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|prostate(1)|skin(2)|stomach(3)|urinary_tract(1)	22	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TGATGTCATCATTTTTGCAACA	0.396													12	59	---	---	---	---					
AC016995.3	0	broad.mit.edu	37	2	38710019	38710019	+	RNA	DEL	T	T	-	rs2005502	by1000genomes	TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr2:38710019delT	ENST00000417039.1	-	0	696																											CTTtaaaaaataaataaataa	0.244													2	4	---	---	---	---					
STAT1	6772	broad.mit.edu	37	2	191845380	191845399	+	Splice_Site	DEL	GGGCTGGCGTTAGGACCTAA	GGGCTGGCGTTAGGACCTAA	-	rs148573907	byFrequency	TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr2:191845380_191845399delGGGCTGGCGTTAGGACCTAA	ENST00000361099.3	-	19	1970_1985	c.1582_splice	c.e19-1	p.528_splice	STAT1_ENST00000409465.1_Splice_Site_p.528_splice|STAT1_ENST00000392322.3_Splice_Site_p.528_splice|STAT1_ENST00000392323.2_Splice_Site_p.530_splice|STAT1_ENST00000540176.1_3'UTR	NM_007315.3	NP_009330.1	P42224	STAT1_HUMAN	signal transducer and activator of transcription 1, 91kDa	528					activation of caspase activity|I-kappaB kinase/NF-kappaB cascade|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway|tyrosine phosphorylation of STAT protein	cytosol|nucleolus|nucleoplasm	calcium ion binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|signal transducer activity	p.A531T(1)		autonomic_ganglia(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(6)|lung(13)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	39			OV - Ovarian serous cystadenocarcinoma(117;0.00434)|Epithelial(96;0.0555)|all cancers(119;0.141)		Fludarabine(DB01073)	GAGACCATCGGGGCTGGCGTTAGGACCTAAACAAATAAAA	0.436													10	53	---	---	---	---					
CDH18	1016	broad.mit.edu	37	5	19747265	19747265	+	Frame_Shift_Del	DEL	A	A	-			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr5:19747265delA	ENST00000507958.1	-	6	1299	c.309delT	c.(307-309)atfs	p.I103fs	CDH18_ENST00000382275.1_Frame_Shift_Del_p.I103fs|CDH18_ENST00000511273.1_Frame_Shift_Del_p.I103fs|CDH18_ENST00000506372.1_Frame_Shift_Del_p.I103fs|CDH18_ENST00000502796.1_Frame_Shift_Del_p.I103fs|CDH18_ENST00000274170.4_Frame_Shift_Del_p.I103fs			Q13634	CAD18_HUMAN	cadherin 18, type 2	103	Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(24)|lung(76)|ovary(5)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)	138	Lung NSC(1;0.00734)|all_lung(1;0.0197)					TGGTATCGTCAATGATAAATA	0.433													16	60	---	---	---	---					
LOC153910	153910	broad.mit.edu	37	6	142860299	142860299	+	RNA	DEL	T	T	-			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr6:142860299delT	ENST00000447311.1	-	0	364					NR_027312.1																						taggccagtatttttttttta	0.473													4	3	---	---	---	---					
PNLIPRP2	5408	broad.mit.edu	37	10	118396277	118396277	+	RNA	DEL	G	G	-	rs148140777	by1000genomes	TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr10:118396277delG	ENST00000537242.1	+	0	962				PNLIPRP2_ENST00000298771.7_RNA|PNLIPRP2_ENST00000433618.4_RNA	NM_005396.4	NP_005387.2	P54317	LIPR2_HUMAN	pancreatic lipase-related protein 2						galactolipid catabolic process|lipid digestion|phospholipid catabolic process|triglyceride metabolic process	extracellular space	acylglycerol lipase activity|calcium ion binding|galactolipase activity|phospholipase activity|triglyceride lipase activity			endometrium(1)|large_intestine(1)|lung(11)|prostate(3)	16				all cancers(201;0.015)		GACAAATTATGGTTTTTTTTT	0.423													2	4	---	---	---	---					
LOC101929735	101929735	broad.mit.edu	37	14	22892201	22892202	+	RNA	INS	-	-	A			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr14:22892201_22892202insA	ENST00000514473.2	-	0	225				AE000661.37_ENST00000535351.1_RNA|AE000661.37_ENST00000537850.1_RNA|AE000661.37_ENST00000545670.1_RNA|AE000661.37_ENST00000541008.1_RNA																							actaaaaatacaaaaaaaaaaa	0.545													2	4	---	---	---	---					
DNM1P47	100216544	broad.mit.edu	37	15	102293062	102293064	+	RNA	DEL	CTC	CTC	-	rs4965539		TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chr15:102293062_102293064delCTC	ENST00000561463.1	+	0	1108_1110																											AGTTCATCTTCTCAGAGCTGCTG	0.576													2	4	---	---	---	---					
DDX3X	1654	broad.mit.edu	37	X	41202088	41202089	+	Splice_Site	DEL	GT	GT	-			TCGA-P3-A5Q5-01A-11D-A28R-08	TCGA-P3-A5Q5-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a57af901-b526-49ff-8fae-21ac6d6455d1	6fac8c8f-b381-4cb2-8701-0d6225b76804	g.chrX:41202088_41202089delGT	ENST00000399959.2	+	6	1397_1398	c.543_splice	c.e6+1	p.S181_splice	DDX3X_ENST00000542215.1_Splice_Site_p.S225_splice|DDX3X_ENST00000478993.1_3'UTR|DDX3X_ENST00000457138.2_Splice_Site_p.S165_splice|DDX3X_ENST00000441189.2_Intron	NM_001193416.1|NM_001193417.1|NM_001356.3	NP_001180345.1|NP_001180346.1|NP_001347.3	O00571	DDX3X_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked	181					interspecies interaction between organisms	cytoplasm|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding|RNA binding			NS(3)|breast(8)|central_nervous_system(36)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(3)|lung(7)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	84						CATATTGAAAGTGTGAGTATTT	0.386										HNSCC(61;0.18)			9	25	---	---	---	---