Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SLC5A3	6526	broad.mit.edu	37	21	35467771	35467771	+	Missense_Mutation	SNP	C	C	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr21:35467771C>T	ENST00000381151.3	+	2	786	c.274C>T	c.(274-276)Ctt>Ttt	p.L92F	MRPS6_ENST00000399312.2_Intron	NM_006933.4	NP_008864.3	P53794	SC5A3_HUMAN	solute carrier family 5 (sodium/myo-inositol cotransporter), member 3	92						integral to plasma membrane	myo-inositol:sodium symporter activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	20						GCTTTTACAACTTCTGGGATG	0.478000													14	88					0	0	1	0	0
ZNF264	9422	broad.mit.edu	37	19	57716772	57716772	+	Silent	SNP	T	T	A			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr19:57716772T>A	ENST00000263095.6	+	3	582	c.168T>A	c.(166-168)ccT>ccA	p.P56P	ZNF264_ENST00000536056.1_Silent_p.P56P	NM_003417.4	NP_003408.1	O43296	ZN264_HUMAN	zinc finger protein 264	56	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(8)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	27		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0135)		CAGGGTGTCCTGTTCCCAAAG	0.512000													3	15					0	0	1	0	0
IQCE	23288	broad.mit.edu	37	7	2613121	2613121	+	Splice_Site	SNP	A	A	G			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr7:2613121A>G	ENST00000402050.2	+	6	648	c.465_splice	c.e6+1	p.K155_splice	IQCE_ENST00000438376.2_Splice_Site_p.K139_splice|IQCE_ENST00000325979.7_Splice_Site_p.K90_splice|IQCE_ENST00000404984.1_Splice_Site_p.K104_splice	NM_001100390.1|NM_152558.3	NP_001093860.1|NP_689771.3	Q6IPM2	IQCE_HUMAN	IQ motif containing E	155										breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	30		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;1.23e-13)		GAGTTAAAGAAGGTAGTATTT	0.393000													8	32					0	0	1	0	0
ABCG2	9429	broad.mit.edu	37	4	89013473	89013473	+	Nonsense_Mutation	SNP	C	C	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr4:89013473C>T	ENST00000237612.3	-	16	2426	c.1881G>A	c.(1879-1881)tgG>tgA	p.W627*	ABCG2_ENST00000515655.1_3'UTR	NM_004827.2	NP_004818.2	Q9UNQ0	ABCG2_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 2	627	ABC transmembrane type-2.				cellular iron ion homeostasis|urate metabolic process	integral to membrane|plasma membrane	ATP binding|heme transporter activity|protein homodimerization activity|xenobiotic-transporting ATPase activity			breast(5)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(13)|lung(10)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	42		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;7.02e-05)	Imatinib(DB00619)|Mitoxantrone(DB01204)|Nicardipine(DB00622)|Nitrendipine(DB01054)|Rosuvastatin(DB01098)|Saquinavir(DB01232)|Topotecan(DB01030)	CGTGATTCTTCCACAAGCCCC	0.363000													8	53					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13871034	13871034	+	Missense_Mutation	SNP	G	G	A	rs146689446		TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr5:13871034G>A	ENST00000265104.4	-	24	3780	c.3676C>T	c.(3676-3678)Cgg>Tgg	p.R1226W	CTB-51A17.1_ENST00000503244.1_RNA	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1226	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					ATCTCACTCCGGTATTTTTTG	0.403000									Kartagener syndrome				15	78					0	0	1	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76556015	76556015	+	Silent	SNP	C	C	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr16:76556015C>T	ENST00000307431.8	+	18	2998	c.2613C>T	c.(2611-2613)aaC>aaT	p.N871N	CNTNAP4_ENST00000476707.1_Silent_p.N875N|CNTNAP4_ENST00000469589.1_3'UTR|CNTNAP4_ENST00000478060.1_Silent_p.N799N|CNTNAP4_ENST00000377504.4_Silent_p.N823N	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4	872	Laminin G-like 3.				cell adhesion|signal transduction	integral to membrane	receptor binding	p.N871K(1)|p.N799K(1)		breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						CCCACTTCAACGACAACCAGT	0.502000													20	145					0	0	1	0	0
NACA2	342538	broad.mit.edu	37	17	59668532	59668532	+	Missense_Mutation	SNP	C	C	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr17:59668532C>T	ENST00000521764.1	-	1	31	c.10G>A	c.(10-12)Gaa>Aaa	p.E4K		NM_199290.3	NP_954984.1	Q9H009	NACA2_HUMAN	nascent polypeptide-associated complex alpha subunit 2	4					protein transport	cytoplasm|nucleus				large_intestine(1)|lung(5)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	12	all_epithelial(1;3.12e-14)					TCTGTGGCTTCGCCCGGCATT	0.582000													4	64					0	0	1	0	0
MTF1	4520	broad.mit.edu	37	1	38287981	38287981	+	Missense_Mutation	SNP	C	C	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr1:38287981C>T	ENST00000373036.4	-	9	1719	c.1579G>A	c.(1579-1581)Gag>Aag	p.E527K		NM_005955.2	NP_005946.2	Q14872	MTF1_HUMAN	metal-regulatory transcription factor 1	527						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|zinc ion binding			endometrium(3)|kidney(5)|large_intestine(6)|liver(1)|lung(12)|ovary(2)|pancreas(1)|prostate(1)	31	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				GGCAGGGGCTCAGTAGTACTT	0.557000													12	58					0	0	1	0	0
TAS2R1	50834	broad.mit.edu	37	5	9629542	9629542	+	Silent	SNP	C	C	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr5:9629542C>T	ENST00000382492.2	-	1	921	c.603G>A	c.(601-603)ctG>ctA	p.L201L	CTD-2001E22.1_ENST00000504182.2_RNA	NM_019599.2	NP_062545.1	Q9NYW7	TA2R1_HUMAN	taste receptor, type 2, member 1	201					chemosensory behavior|sensory perception of taste	integral to membrane	taste receptor activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(19)|ovary(3)|prostate(1)|skin(1)|stomach(1)	39						TGTGCCTCCCCAGAGAGAAAA	0.498000													4	83					0	0	1	0	0
PLCD1	5333	broad.mit.edu	37	3	38058144	38058144	+	Missense_Mutation	SNP	C	C	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr3:38058144C>T	ENST00000463876.1	-	3	682	c.329G>A	c.(328-330)cGt>cAt	p.R110H	PLCD1_ENST00000479619.1_5'UTR|PLCD1_ENST00000334661.4_Missense_Mutation_p.R89H	NM_001130964.1	NP_001124436.1	P51178	PLCD1_HUMAN	phospholipase C, delta 1	89	PH.				intracellular signal transduction|lipid catabolic process|phospholipid metabolic process	cytoplasm	calcium ion binding|GTPase activating protein binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(6)|prostate(1)|skin(1)	24				KIRC - Kidney renal clear cell carcinoma(284;0.0519)|Kidney(284;0.0653)		GGGCACATCACGGGCGAACTT	0.612000													5	14					0	0	1	0	0
PCNXL3	399909	broad.mit.edu	37	11	65401690	65401690	+	Missense_Mutation	SNP	G	G	A			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr11:65401690G>A	ENST00000355703.3	+	28	5103	c.4564G>A	c.(4564-4566)Ggc>Agc	p.G1522S	PCNXL3_ENST00000531280.1_3'UTR	NM_032223.2	NP_115599.2	Q9H6A9	PCX3_HUMAN	pecanex-like 3 (Drosophila)	1522						integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)	13						GCGGGTGCCCGGCTATGCCGA	0.622000													3	28					0	0	1	0	0
FLJ33360	401172	broad.mit.edu	37	5	6337355	6337355	+	RNA	SNP	C	C	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr5:6337355C>T	ENST00000507444.1	-	0	50					NR_028351.1																						ACAGCTTTTTCGATGCTCACT	0.527000													11	77					0	0	1	0	0
NECAP2	55707	broad.mit.edu	37	1	16785408	16785408	+	Missense_Mutation	SNP	G	G	A			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr1:16785408G>A	ENST00000443980.2	+	7	765	c.739G>A	c.(739-741)Gtg>Atg	p.V247M	NECAP2_ENST00000457722.2_3'UTR|NECAP2_ENST00000406746.1_3'UTR|NECAP2_ENST00000337132.5_3'UTR|NECAP2_ENST00000504551.2_3'UTR	NM_001145277.1	NP_001138749.1	Q9NVZ3	NECP2_HUMAN	NECAP endocytosis associated 2	249					endocytosis|protein transport	clathrin vesicle coat|coated pit|plasma membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	9		Colorectal(325;0.000147)|Renal(390;0.00145)|Lung NSC(340;0.00215)|Breast(348;0.00224)|all_lung(284;0.00351)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(227;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|Kidney(64;0.000181)|KIRC - Kidney renal clear cell carcinoma(64;0.00268)|STAD - Stomach adenocarcinoma(196;0.012)|READ - Rectum adenocarcinoma(331;0.0649)		TTTTCCTCATGTGACTTCTGG	0.577000													9	39					0	0	1	0	0
C4orf40	401137	broad.mit.edu	37	4	71024299	71024299	+	Silent	SNP	G	G	A			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr4:71024299G>A	ENST00000344526.5	+	3	519	c.330G>A	c.(328-330)ccG>ccA	p.P110P	C4orf40_ENST00000502294.1_Silent_p.P110P|C4orf40_ENST00000502441.2_3'UTR	NM_214711.3	NP_999876.2	Q6MZM9	CD040_HUMAN	chromosome 4 open reading frame 40	110						extracellular region				breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12						GGGGTTTCCCGTTTGTCCCTC	0.532000													45	211					0	0	1	0	0
CEP192	55125	broad.mit.edu	37	18	13048862	13048862	+	Missense_Mutation	SNP	C	C	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr18:13048862C>T	ENST00000506447.1	+	16	2152	c.2072C>T	c.(2071-2073)aCt>aTt	p.T691I	CEP192_ENST00000325971.8_Missense_Mutation_p.T95I|CEP192_ENST00000430049.2_Missense_Mutation_p.T216I	NM_032142.3	NP_115518.3	B7ZMF0	B7ZMF0_HUMAN	centrosomal protein 192kDa	286										NS(1)|breast(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(36)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						TTCTAGGACACTTTCTTCATG	0.398000													15	34					0	0	1	0	0
UBR4	23352	broad.mit.edu	37	1	19468218	19468218	+	Missense_Mutation	SNP	C	C	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr1:19468218C>T	ENST00000375267.2	-	56	8236	c.8233G>A	c.(8233-8235)Ggg>Agg	p.G2745R	UBR4_ENST00000375254.3_Missense_Mutation_p.G2745R|UBR4_ENST00000375217.2_Missense_Mutation_p.G2773R|UBR4_ENST00000375226.2_Missense_Mutation_p.G2756R			Q5T4S7	UBR4_HUMAN	ubiquitin protein ligase E3 component n-recognin 4	2745					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		TTCGGGATCCCTGATGACTGC	0.507000													14	108					0	0	1	0	0
NCOA7	135112	broad.mit.edu	37	6	126211861	126211861	+	Missense_Mutation	SNP	G	G	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr6:126211861G>T	ENST00000368357.3	+	11	2353	c.2001G>T	c.(1999-2001)atG>atT	p.M667I	NCOA7_ENST00000392477.2_Missense_Mutation_p.M667I|NCOA7_ENST00000229634.9_Missense_Mutation_p.M552I	NM_001199619.1|NM_001199620.1	NP_001186548.1|NP_001186549.1	Q8NI08	NCOA7_HUMAN	nuclear receptor coactivator 7	667					cell wall macromolecule catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(6)|lung(16)|ovary(1)|skin(1)|soft_tissue(1)|urinary_tract(2)	39				UCEC - Uterine corpus endometrioid carcinoma (4;0.0803)|GBM - Glioblastoma multiforme(226;0.0193)|all cancers(137;0.237)		GAAAACCAATGAGAAAATCCT	0.473000													5	47					0.000602214	0.000624939	1	1	0
CCT4	10575	broad.mit.edu	37	2	62104184	62104184	+	Silent	SNP	C	C	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr2:62104184C>T	ENST00000394440.3	-	7	944	c.648G>A	c.(646-648)ggG>ggA	p.G216G	AC107081.5_ENST00000425779.1_RNA|CCT4_ENST00000538252.1_Silent_p.G160G|CCT4_ENST00000544079.1_Silent_p.G186G|CCT4_ENST00000544185.1_Silent_p.G66G	NM_006430.3	NP_006421.2	P50991	TCPD_HUMAN	chaperonin containing TCP1, subunit 4 (delta)	216					'de novo' posttranslational protein folding	melanosome|microtubule organizing center|nucleus	ATP binding|unfolded protein binding			breast(1)|large_intestine(2)|lung(6)|ovary(2)	11	Lung NSC(7;0.035)|all_lung(7;0.0691)		LUSC - Lung squamous cell carcinoma(7;6.5e-06)|Epithelial(17;0.0647)|all cancers(80;0.221)			CATCAATTGTCCCACTAAGGA	0.398000													9	48					0	0	1	0	0
OR2T6	254879	broad.mit.edu	37	1	248551037	248551037	+	Missense_Mutation	SNP	G	G	A			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr1:248551037G>A	ENST00000355728.2	+	1	128	c.128G>A	c.(127-129)gGg>gAg	p.G43E		NM_001005471.1	NP_001005471.1	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T, member 6	43					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(5)|lung(38)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ATAGCTAATGGGGTCATGATC	0.473000													7	95					0	0	1	0	0
TRIM23	373	broad.mit.edu	37	5	64906779	64906779	+	Missense_Mutation	SNP	T	T	A			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr5:64906779T>A	ENST00000231524.9	-	5	1108	c.737A>T	c.(736-738)gAt>gTt	p.D246V	TRIM23_ENST00000381018.3_Missense_Mutation_p.D246V|TRIM23_ENST00000274327.7_Missense_Mutation_p.D246V	NM_001656.3	NP_001647.1	P36406	TRI23_HUMAN	tripartite motif containing 23	246					interspecies interaction between organisms|small GTPase mediated signal transduction	Golgi membrane|lysosomal membrane	enzyme activator activity|GDP binding|GTP binding|GTPase activity|protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(5)|ovary(4)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	28		Lung NSC(167;3.24e-06)|Prostate(74;0.0138)|Breast(144;0.0433)|Ovarian(174;0.0545)|Colorectal(97;0.234)		Lung(70;0.00473)		TCTGGAATAATCTGAGATTTC	0.393000													7	36					0	0	1	0	0
PRAMEF1	65121	broad.mit.edu	37	1	12855611	12855611	+	Missense_Mutation	SNP	C	C	A			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr1:12855611C>A	ENST00000332296.7	+	4	994	c.891C>A	c.(889-891)aaC>aaA	p.N297K	PRAMEF1_ENST00000400814.3_Missense_Mutation_p.N52K	NM_023013.2	NP_075389.1	O95521	PRAM1_HUMAN	PRAME family member 1	297										cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	35	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CCTTGGAGAACTTGGAATTAA	0.468000													4	112					5.4927e-09	6.08252e-09	1	1	0
GRID1	2894	broad.mit.edu	37	10	87373297	87373297	+	Missense_Mutation	SNP	C	C	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr10:87373297C>T	ENST00000327946.7	-	15	2553	c.2468G>A	c.(2467-2469)gGc>gAc	p.G823D	GRID1_ENST00000536331.1_Missense_Mutation_p.G394D	NM_017551.2	NP_060021.1	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	823						cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(46)|ovary(5)|prostate(4)|skin(5)|stomach(4)|upper_aerodigestive_tract(5)	106					L-Glutamic Acid(DB00142)	GAGGGATTTGCCGTCGGCCTG	0.652000										Multiple Myeloma(13;0.14)			4	115					0	0	1	0	0
ATG9B	285973	broad.mit.edu	37	7	150721007	150721007	+	Translation_Start_Site	SNP	G	G	A			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr7:150721007G>A	ENST00000444312.1	-	0	579				ATG9B_ENST00000377974.2_Silent_p.H168H|ATG9B_ENST00000605938.1_Silent_p.H168H|ATG9B_ENST00000605952.1_Silent_p.H168H|ATG9B_ENST00000494791.1_5'UTR			Q674R7	ATG9B_HUMAN	autophagy related 9B						autophagic vacuole assembly	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane				cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(1)|ovary(4)|prostate(1)	14	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GCTCCTCCCCGTGGATGGGTG	0.612000													3	6					0	0	1	0	0
ZDHHC6	64429	broad.mit.edu	37	10	114194100	114194100	+	Silent	SNP	T	T	C			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr10:114194100T>C	ENST00000369405.3	-	7	1281	c.858A>G	c.(856-858)ggA>ggG	p.G286G	ZDHHC6_ENST00000369404.3_Silent_p.G282G	NM_022494.1	NP_071939.1	Q9H6R6	ZDHC6_HUMAN	zinc finger, DHHC-type containing 6	286						integral to membrane	acyltransferase activity|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(2)|lung(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	14		Colorectal(252;0.198)		Epithelial(162;0.0291)|all cancers(201;0.117)		GCCACTCAAGTCCATCTCCTT	0.418000													4	65					0	0	1	0	0
IKBKB	3551	broad.mit.edu	37	8	42171842	42171842	+	Missense_Mutation	SNP	A	A	G			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr8:42171842A>G	ENST00000520810.1	+	9	881	c.695A>G	c.(694-696)cAt>cGt	p.H232R	IKBKB_ENST00000520835.1_Missense_Mutation_p.H230R|IKBKB_ENST00000522147.1_Intron|IKBKB_ENST00000379708.3_Missense_Mutation_p.H9R|IKBKB_ENST00000416505.2_Missense_Mutation_p.H173R	NM_001556.2	NP_001547.1	O14920	IKKB_HUMAN	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	232	Protein kinase.				anti-apoptosis|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|membrane raft	ATP binding|identical protein binding|IkappaB kinase activity			breast(4)|lung(1)|ovary(2)|skin(1)	8	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;6.21e-12)|Lung NSC(13;1.04e-10)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;1.37e-10)|Colorectal(10;0.00102)|OV - Ovarian serous cystadenocarcinoma(14;0.00168)|Lung(22;0.00467)|LUSC - Lung squamous cell carcinoma(45;0.024)|COAD - Colon adenocarcinoma(11;0.0264)		Arsenic trioxide(DB01169)|Auranofin(DB00995)	ATTTGCAGGCATTCAAAAGTG	0.423000													18	176					0	0	1	0	0
ARHGAP17	55114	broad.mit.edu	37	16	24950790	24950790	+	Missense_Mutation	SNP	G	G	A			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr16:24950790G>A	ENST00000289968.6	-	17	1688	c.1619C>T	c.(1618-1620)cCa>cTa	p.P540L	ARHGAP17_ENST00000441763.2_3'UTR|ARHGAP17_ENST00000303665.5_Intron	NM_001006634.1	NP_001006635.1	Q68EM7	RHG17_HUMAN	Rho GTPase activating protein 17	540	Pro-rich.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|tight junction	GTPase activator activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(13)|ovary(1)|urinary_tract(2)	30				GBM - Glioblastoma multiforme(48;0.0407)		AGGGGGCTCTGGGCCAGCGGG	0.677000													3	24					0	0	1	0	0
STK32C	282974	broad.mit.edu	37	10	134039104	134039104	+	Silent	SNP	G	G	T	rs79590008	by1000genomes	TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr10:134039104G>T	ENST00000368622.1	-	6	729	c.348C>A	c.(346-348)acC>acA	p.T116T	STK32C_ENST00000368625.4_Silent_p.T246T			Q86UX6	ST32C_HUMAN	serine/threonine kinase 32C	233	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(1)|endometrium(2)|large_intestine(2)|lung(15)|ovary(2)|skin(1)	23		all_cancers(35;2.72e-11)|all_epithelial(44;2.33e-08)|Lung NSC(174;0.000855)|all_lung(145;0.00146)|all_neural(114;0.0299)|Breast(234;0.106)|Colorectal(31;0.112)|Melanoma(40;0.124)|Glioma(114;0.203)		Epithelial(32;3.99e-05)|all cancers(32;5.58e-05)|OV - Ovarian serous cystadenocarcinoma(35;9.96e-05)|BRCA - Breast invasive adenocarcinoma(275;0.222)		TGTTGAAGTCGGTCAGGTGTG	0.617000													31	147					7.11191e-15	8.09286e-15	1	1	0
LDB3	11155	broad.mit.edu	37	10	88476357	88476357	+	Missense_Mutation	SNP	C	C	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr10:88476357C>T	ENST00000429277.2	+	10	1665	c.1520C>T	c.(1519-1521)cCg>cTg	p.P507L	LDB3_ENST00000352360.5_Missense_Mutation_p.P245L|LDB3_ENST00000458213.2_Missense_Mutation_p.P392L|LDB3_ENST00000361373.4_Missense_Mutation_p.P502L|LDB3_ENST00000263066.6_Missense_Mutation_p.P392L	NM_001171610.1	NP_001165081.1	O75112	LDB3_HUMAN	LIM domain binding 3	502						cytoskeleton|perinuclear region of cytoplasm|pseudopodium	zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|soft_tissue(1)	25						AAGTTTGCCCCGGGCAAGAGC	0.672000													20	116					0	0	1	0	0
ARHGEF38	54848	broad.mit.edu	37	4	106474093	106474093	+	Silent	SNP	G	G	A			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr4:106474093G>A	ENST00000420470.2	+	1	315	c.171G>A	c.(169-171)agG>agA	p.R57R	ARHGEF38_ENST00000265154.2_Silent_p.R57R	NM_001242729.1	NP_001229658.1	Q9NXL2	ARH38_HUMAN	Rho guanine nucleotide exchange factor (GEF) 38	57					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(1)|endometrium(1)|large_intestine(2)|lung(4)|ovary(3)	11						AATCTGACAGGACTGAATACA	0.458000													8	39					0	0	1	0	0
TRAPPC9	83696	broad.mit.edu	37	8	141321414	141321414	+	Missense_Mutation	SNP	C	C	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr8:141321414C>T	ENST00000389328.4	-	10	1863	c.1849G>A	c.(1849-1851)Gag>Aag	p.E617K	TRAPPC9_ENST00000389327.3_Missense_Mutation_p.E510K|TRAPPC9_ENST00000438773.2_Missense_Mutation_p.E519K	NM_031466.5	NP_113654.4	Q96Q05	TPPC9_HUMAN	trafficking protein particle complex 9	519					cell differentiation	endoplasmic reticulum|Golgi apparatus				breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(16)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	47						GCGATGGGCTCCATGGTCCCA	0.537000													9	71					0	0	1	0	0
TPR	7175	broad.mit.edu	37	1	186292894	186292894	+	Missense_Mutation	SNP	G	G	A			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr1:186292894G>A	ENST00000367478.3	-	43	6517	c.6221C>T	c.(6220-6222)cCg>cTg	p.P2074L		NM_003292.2	NP_003283.2	P12270	TPR_HUMAN	translocated promoter region, nuclear basket protein	2074					carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			autonomic_ganglia(1)|breast(5)|central_nervous_system(4)|cervix(2)|endometrium(9)|kidney(12)|large_intestine(23)|liver(1)|lung(45)|ovary(2)|pancreas(1)|prostate(6)|skin(3)|stomach(1)|urinary_tract(8)	123		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		TGGGCGTCTCGGTGACTGAGG	0.502000			T	NTRK1	papillary thyroid								4	111					0	0	1	0	0
PLD1	5337	broad.mit.edu	37	3	171338283	171338283	+	Nonsense_Mutation	SNP	G	G	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr3:171338283G>T	ENST00000356327.5	-	23	2577	c.2507C>A	c.(2506-2508)tCa>tAa	p.S836*	PLD1_ENST00000342215.6_3'UTR|PLD1_ENST00000351298.4_Nonsense_Mutation_p.S874*|PLD1_ENST00000340989.4_Nonsense_Mutation_p.S874*	NM_001130081.2	NP_001123553.1	Q13393	PLD1_HUMAN	phospholipase D1, phosphatidylcholine-specific	874	Catalytic.				cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(15)|lung(27)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	63	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)	ACCACAGAATGATATGTAATT	0.313000													5	57					0.00116845	0.00120496	1	1	0
CACNA1B	774	broad.mit.edu	37	9	140772598	140772598	+	Silent	SNP	C	C	G			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr9:140772598C>G	ENST00000371372.1	+	1	358	c.213C>G	c.(211-213)gtC>gtG	p.V71V	CACNA1B_ENST00000371355.4_Silent_p.V71V|CACNA1B_ENST00000371357.1_Silent_p.V71V|CACNA1B_ENST00000371363.1_Silent_p.V71V|CACNA1B_ENST00000277551.2_Silent_p.V71V|RP11-188C12.3_ENST00000371390.1_RNA|CACNA1B_ENST00000277549.5_5'UTR	NM_000718.3|NM_001243812.1	NP_000709.1|NP_001230741.1	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	71					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	GCTTCACCGTCAACCGCTCGC	0.662000													3	22					0	0	1	0	0
ZNF132	7691	broad.mit.edu	37	19	58944698	58944698	+	Missense_Mutation	SNP	G	G	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr19:58944698G>T	ENST00000254166.3	-	3	2513	c.2113C>A	c.(2113-2115)Cat>Aat	p.H705N		NM_003433.3	NP_003424.3	P52740	ZN132_HUMAN	zinc finger protein 132	705						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(1)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	19		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0171)|Lung(386;0.182)		ACTCAGGTATGAATCTTTTTA	0.433000													19	105					4.96729e-08	5.46402e-08	1	1	0
FUT3	2525	broad.mit.edu	37	19	5844507	5844507	+	Missense_Mutation	SNP	G	G	T	rs141188376		TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr19:5844507G>T	ENST00000303225.6	-	3	978	c.344C>A	c.(343-345)tCc>tAc	p.S115Y	FUT3_ENST00000458379.2_Missense_Mutation_p.S115Y|FUT3_ENST00000589620.1_Missense_Mutation_p.S115Y|FUT3_ENST00000589918.1_Missense_Mutation_p.S115Y	NM_000149.3	NP_000140.1	P21217	FUT3_HUMAN	fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)	115					protein glycosylation	Golgi cisterna membrane|integral to membrane|membrane fraction	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(5)|upper_aerodigestive_tract(1)	14						CTTAGGGTTGGACATGATATC	0.622000													15	111					7.93312e-07	8.66864e-07	1	1	0
REG1P	5969	broad.mit.edu	37	2	79363180	79363180	+	RNA	SNP	C	C	A			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr2:79363180C>A	ENST00000444841.1	-	0	1158																											CAGGGACCCACTACTCCACTG	0.532000													3	24					0.004672	0.00478807	1	1	0
C19orf35	374872	broad.mit.edu	37	19	2276297	2276297	+	Missense_Mutation	SNP	C	C	G			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr19:2276297C>G	ENST00000342063.3	-	4	897	c.804G>C	c.(802-804)gaG>gaC	p.E268D		NM_198532.2	NP_940934.1	Q6ZS72	CS035_HUMAN	chromosome 19 open reading frame 35	268										large_intestine(1)|lung(5)|pancreas(1)|prostate(1)	8				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCGTGCAGGCCTCCGCCAGCC	0.741000													3	12					0	0	1	0	0
BRCA2	675	broad.mit.edu	37	13	32893410	32893410	+	Silent	SNP	G	G	A	rs80359341		TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr13:32893410G>A	ENST00000544455.1	+	3	491	c.264G>A	c.(262-264)ctG>ctA	p.L88L	BRCA2_ENST00000380152.3_Silent_p.L88L	NM_000059.3	NP_000050.2	P51587	BRCA2_HUMAN	breast cancer 2, early onset	88					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			NS(3)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(32)|liver(1)|lung(41)|oesophagus(5)|ovary(22)|pancreas(4)|prostate(3)|salivary_gland(1)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	183		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		GGCTGACTCTGCCGCTGTACC	0.363000			"""D, Mis, N, F, S"""		"""breast, ovarian, pancreatic"""	"""breast, ovarian, pancreatic, leukemia  (FANCB, FANCD1)"""		Homologous recombination	Pancreatic Cancer, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Prostate Cancer;Hereditary Breast-Ovarian Cancer, BRCA2 type;Fanconi Anemia type D1, bi-allelic BRCA2 mutations;Fanconi Anemia	TCGA Ovarian(8;0.087)			12	53					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141272298	141272298	+	Silent	SNP	T	T	C			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr2:141272298T>C	ENST00000389484.3	-	51	9164	c.8193A>G	c.(8191-8193)aaA>aaG	p.K2731K		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	2731	LDL-receptor class A 16.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TAGAAATACATTTTTGTGCGG	0.378000										TSP Lung(27;0.18)			14	61					0	0	1	0	0
TNNT3	7140	broad.mit.edu	37	11	1959683	1959683	+	Silent	SNP	G	G	A			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr11:1959683G>A	ENST00000381558.1	+	15	993	c.714G>A	c.(712-714)ggG>ggA	p.G238G	TNNT3_ENST00000381548.3_Silent_p.G248G|TNNT3_ENST00000381549.3_Silent_p.G238G|TNNT3_ENST00000381579.3_Silent_p.G238G|TNNT3_ENST00000360603.3_Silent_p.G240G|TNNT3_ENST00000278317.6_Silent_p.G246G|TNNT3_ENST00000397304.2_Silent_p.G227G|TNNT3_ENST00000446240.1_Silent_p.G227G|TNNT3_ENST00000397301.1_Silent_p.G257G|TNNT3_ENST00000381589.3_Silent_p.G244G|TNNT3_ENST00000381561.4_Silent_p.G249G			P45378	TNNT3_HUMAN	troponin T type 3 (skeletal, fast)	257					muscle filament sliding|regulation of ATPase activity|regulation of striated muscle contraction|skeletal muscle contraction	cytosol|troponin complex	calcium-dependent protein binding|tropomyosin binding|troponin C binding|troponin I binding			breast(2)|endometrium(1)|kidney(1)|lung(8)|ovary(1)|prostate(1)|skin(4)|stomach(1)	19		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00253)|Lung(200;0.0333)|LUSC - Lung squamous cell carcinoma(625;0.0826)		AGAAGGCTGGGACCCCAGCCA	0.662000													25	82					0	0	1	0	0
LENG9	94059	broad.mit.edu	37	19	54973383	54973383	+	Missense_Mutation	SNP	C	C	G			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr19:54973383C>G	ENST00000333834.4	-	1	1511	c.1393G>C	c.(1393-1395)Gag>Cag	p.E465Q		NM_198988.1	NP_945339.2	Q96B70	LENG9_HUMAN	leukocyte receptor cluster (LRC) member 9	465					RNA metabolic process	intracellular	catalytic activity|nucleic acid binding|zinc ion binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(5)	11	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.134)		AGGGTGAACTCCAGCTTGGGG	0.652000													22	118					0	0	1	0	0
C3AR1	719	broad.mit.edu	37	12	8212660	8212660	+	Missense_Mutation	SNP	T	T	G			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr12:8212660T>G	ENST00000307637.4	-	2	325	c.122A>C	c.(121-123)aAt>aCt	p.N41T		NM_004054.2	NP_004045.1	Q16581	C3AR_HUMAN	complement component 3a receptor 1	41					blood circulation|chemotaxis|elevation of cytosolic calcium ion concentration|inflammatory response	integral to plasma membrane	C3a anaphylatoxin receptor activity|complement component C3a receptor activity|phosphatidylinositol phospholipase C activity			breast(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(1)	20				Kidney(36;0.0893)		CACCAGCCCATTGCCTGGCAA	0.537000													18	80					0	0	1	0	0
MIR3654	100500804	broad.mit.edu	37	11	62348581	62348581	+	Silent	SNP	G	G	A			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr11:62348581G>A	ENST00000496634.2	-	4	732	c.687C>T	c.(685-687)ccC>ccT	p.P229P	TUT1_ENST00000476907.1_Silent_p.P229P|TUT1_ENST00000308436.7_Silent_p.P267P																NS(1)	1						CACTCACCTGGGGCTCTTCCA	0.522000													22	111					0	0	1	0	0
SEZ6	124925	broad.mit.edu	37	17	27308504	27308504	+	Silent	SNP	G	G	A			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr17:27308504G>A	ENST00000317338.12	-	2	1037	c.609C>T	c.(607-609)ggC>ggT	p.G203G	SEZ6_ENST00000335960.6_Silent_p.G203G|SEZ6_ENST00000442608.3_Silent_p.G203G|PIPOX_ENST00000583215.1_Intron|SEZ6_ENST00000360295.9_Silent_p.G203G			Q53EL9	SEZ6_HUMAN	seizure related 6 homolog (mouse)	203						integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(4)|lung(11)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	29	Lung NSC(42;0.0137)		Epithelial(11;4.73e-06)|all cancers(11;2.91e-05)|BRCA - Breast invasive adenocarcinoma(11;8.06e-05)|OV - Ovarian serous cystadenocarcinoma(11;0.111)			CGATCCCTGCGCCCTGGGACA	0.602000													3	16					0	0	1	0	0
TUBB8P7	197331	broad.mit.edu	37	16	90162513	90162513	+	RNA	SNP	T	T	C			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr16:90162513T>C	ENST00000567960.1	+	0	1249				TUBB8P7_ENST00000564451.1_RNA														p.N415N(2)									GCAACATGAATGACCTGGTGT	0.537000													4	141					0	0	1	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125192141	125192141	+	Missense_Mutation	SNP	G	G	A			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr2:125192141G>A	ENST00000431078.1	+	5	974	c.610G>A	c.(610-612)Gtg>Atg	p.V204M		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	204	Laminin G-like 1.				cell adhesion|signal transduction	integral to membrane	receptor binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		TCTCAAAGATGTGATCTCCCT	0.493000													8	67					0	0	1	0	0
CTC-260E6.6	0	broad.mit.edu	37	19	20369553	20369553	+	RNA	SNP	G	G	A			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr19:20369553G>A	ENST00000593655.1	-	0	199																											CCCAGTATTAGAAGGCTTTTC	0.448000													8	76					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1263911	1263911	+	Missense_Mutation	SNP	C	C	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr11:1263911C>T	ENST00000447027.1	+	31	5868	c.5810C>T	c.(5809-5811)cCc>cTc	p.P1937L	MUC5B_ENST00000529681.1_Missense_Mutation_p.P1934L|RP11-532E4.2_ENST00000532061.2_RNA			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	1934	11 X approximate tandem repeats, Ser/Thr- rich.|7 X Cys-rich subdomain repeats.|Thr-rich.			PPPKVLT -> GTPHVS (in Ref. 4; CAA96577).	cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		AGAACAGCTCCCCCTCCCAAA	0.642000													38	153					0	0	1	0	0
KCTD7	154881	broad.mit.edu	37	7	66103260	66103260	+	Missense_Mutation	SNP	G	G	A			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr7:66103260G>A	ENST00000275532.3	+	3	519	c.335G>A	c.(334-336)cGc>cAc	p.R112H	KCTD7_ENST00000443322.1_Missense_Mutation_p.R112H	NM_001167961.2|NM_153033.4	NP_001161433.1|NP_694578.1	Q96MP8	KCTD7_HUMAN	potassium channel tetramerization domain containing 7	112	BTB.					voltage-gated potassium channel complex	voltage-gated potassium channel activity	p.R112H(1)		central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|urinary_tract(1)	16						AATTTCCTGCGCTCAGGGGAC	0.567000													12	97					0	0	1	0	0
SLC27A4	10999	broad.mit.edu	37	9	131107581	131107581	+	Silent	SNP	C	C	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr9:131107581C>T	ENST00000300456.3	+	3	426	c.309C>T	c.(307-309)acC>acT	p.T103T	SLC27A4_ENST00000372870.1_Intron	NM_005094.3	NP_005085.2	Q6P1M0	S27A4_HUMAN	solute carrier family 27 (fatty acid transporter), member 4	103					long-chain fatty acid transport|transmembrane transport	integral to membrane	fatty acid transporter activity|nucleotide binding|protein binding			autonomic_ganglia(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(2)	13						CCCACTGGACCTTCCGCCAGC	0.622000													9	48					0	0	1	0	0
KIAA0895L	653319	broad.mit.edu	37	16	67214239	67214239	+	Missense_Mutation	SNP	C	C	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr16:67214239C>T	ENST00000290881.7	-	3	1201	c.275G>A	c.(274-276)cGg>cAg	p.R92Q	KIAA0895L_ENST00000561621.1_Missense_Mutation_p.R92Q|KIAA0895L_ENST00000563902.1_Missense_Mutation_p.R92Q|KIAA0895L_ENST00000563831.2_Intron			Q68EN5	K895L_HUMAN	KIAA0895-like	92										breast(2)|endometrium(5)|kidney(2)|large_intestine(3)|lung(2)|prostate(2)|skin(1)	17						GCCACGCCCCCGCCGGCCAGT	0.667000													9	23					0	0	1	0	0
PCDHB11	56125	broad.mit.edu	37	5	140580049	140580049	+	Silent	SNP	C	C	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr5:140580049C>T	ENST00000354757.3	+	1	702	c.702C>T	c.(700-702)gaC>gaT	p.D234D	PCDHB11_ENST00000536699.1_Intron	NM_018931.2	NP_061754.1	Q9Y5F2	PCDBB_HUMAN		234	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGGTTGTGGACATTAATGACA	0.507000													28	111					0	0	1	0	0
C5orf15	56951	broad.mit.edu	37	5	133295400	133295400	+	Missense_Mutation	SNP	G	G	A			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr5:133295400G>A	ENST00000231512.3	-	2	653	c.451C>T	c.(451-453)Cca>Tca	p.P151S	C5orf15_ENST00000507191.1_5'UTR	NM_020199.2	NP_064584.1	Q8NC54	KCT2_HUMAN	chromosome 5 open reading frame 15	151						integral to membrane				endometrium(2)|large_intestine(1)|lung(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00806)|Kidney(363;0.02)			TCATAGTCTGGTTCTCCATAA	0.473000													14	40					0	0	1	0	0
FAT1	2195	broad.mit.edu	37	4	187539163	187539163	+	Silent	SNP	G	G	C			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr4:187539163G>C	ENST00000441802.2	-	10	8786	c.8577C>G	c.(8575-8577)tcC>tcG	p.S2859S		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	2859	Cadherin 26.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						TAATGGCAAAGGATTCAATGA	0.413000										HNSCC(5;0.00058)			20	67					0	0	1	0	0
ZBTB32	27033	broad.mit.edu	37	19	36205627	36205627	+	Silent	SNP	C	C	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr19:36205627C>T	ENST00000392197.2	+	3	417	c.99C>T	c.(97-99)atC>atT	p.I33I	ZBTB32_ENST00000262630.3_Silent_p.I33I			Q9Y2Y4	ZBT32_HUMAN	zinc finger and BTB domain containing 32	33	BTB.				DNA repair|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleoplasm	DNA binding|protein binding|transcription corepressor activity|zinc ion binding			large_intestine(5)|lung(1)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	14	all_lung(56;2.22e-07)|Lung NSC(56;3.47e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			ATACTCTGATCACCGTAGGGA	0.642000													13	120					0	0	1	0	0
CASP8	841	broad.mit.edu	37	2	202149674	202149674	+	Missense_Mutation	SNP	G	G	A			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr2:202149674G>A	ENST00000358485.4	+	8	1311	c.1115G>A	c.(1114-1116)tGt>tAt	p.C372Y	CASP8_ENST00000392259.2_3'UTR|CASP8_ENST00000392266.3_3'UTR|CASP8_ENST00000264275.5_Missense_Mutation_p.C330Y|CASP8_ENST00000432109.2_Missense_Mutation_p.C313Y|CASP8_ENST00000323492.7_Missense_Mutation_p.C298Y|CASP8_ENST00000264274.9_Missense_Mutation_p.C229Y	NM_001080125.1	NP_001073594.1	Q14790	CASP8_HUMAN	caspase 8, apoptosis-related cysteine peptidase	313					activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding			breast(5)|cervix(2)|endometrium(6)|large_intestine(11)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(9)|urinary_tract(3)	52						TTCATCTGCTGTATCCTCTCC	0.483000										HNSCC(4;0.00038)			36	119					0	0	1	0	0
FAM160A2	84067	broad.mit.edu	37	11	6233034	6233034	+	Missense_Mutation	SNP	G	G	A			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr11:6233034G>A	ENST00000265978.4	-	12	3021	c.2663C>T	c.(2662-2664)gCc>gTc	p.A888V	FAM160A2_ENST00000449352.2_Missense_Mutation_p.A874V|FAM160A2_ENST00000529360.1_5'UTR	NM_001098794.1|NM_032127.3	NP_001092264.1|NP_115503.2	Q8N612	F16A2_HUMAN	family with sequence similarity 160, member A2	874					early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|protein transport	FHF complex	protein binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(7)|liver(1)|lung(14)|ovary(2)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						CGCCTGCCGGGCCCTGGTTGG	0.607000													5	242					0	0	1	0	0
GTSE1	51512	broad.mit.edu	37	22	46704348	46704348	+	Nonsense_Mutation	SNP	G	G	A			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr22:46704348G>A	ENST00000454366.1	+	4	482	c.270G>A	c.(268-270)tgG>tgA	p.W90*		NM_016426.6	NP_057510.4	Q9NYZ3	GTSE1_HUMAN	G-2 and S-phase expressed 1	71					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G2 phase of mitotic cell cycle|microtubule-based process	cytoplasmic microtubule				NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(3)	27		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00462)		CCTTTGCCTGGAGCCCTCTGG	0.527000													17	177					0	0	1	0	0
RPE65	6121	broad.mit.edu	37	1	68896860	68896860	+	Splice_Site	SNP	C	C	A			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr1:68896860C>A	ENST00000262340.5	-	13	1392		c.e13-1			NM_000329.2	NP_000320.1	Q16518	RPE65_HUMAN	retinal pigment epithelium-specific protein 65kDa						visual perception	cytoplasm|plasma membrane	all-trans-retinyl-palmitate hydrolase activity|metal ion binding|retinol isomerase activity			central_nervous_system(1)|kidney(3)|large_intestine(12)|lung(15)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	35						GCTTACAGAGCTGTTTGTGAG	0.373000													4	35					0.00909568	0.00915114	1	1	0
EPHA5	2044	broad.mit.edu	37	4	66217121	66217121	+	Missense_Mutation	SNP	C	C	A			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr4:66217121C>A	ENST00000273854.3	-	14	3094	c.2494G>T	c.(2494-2496)Gcc>Tcc	p.A832S	EPHA5_ENST00000432638.2_Missense_Mutation_p.A669S|EPHA5_ENST00000354839.4_Missense_Mutation_p.A810S|EPHA5_ENST00000511294.1_Missense_Mutation_p.A833S	NM_004439.5	NP_004430.4	P54756	EPHA5_HUMAN	EPH receptor A5	832	Protein kinase.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(25)|liver(1)|lung(76)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	142						GTGGTGTAGGCTGCCTCGGGA	0.408000										TSP Lung(17;0.13)			10	86					3.07112e-06	3.29048e-06	1	1	0
KMT2D	8085	broad.mit.edu	37	12	49438264	49438264	+	Missense_Mutation	SNP	G	G	A			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr12:49438264G>A	ENST00000301067.7	-	20	5004	c.5005C>T	c.(5005-5007)Ccc>Tcc	p.P1669S		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		GGGCTGACGGGGCCCTCCAGT	0.532000											OREG0021780	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	65					0	0	1	0	0
PTH2	113091	broad.mit.edu	37	19	49926533	49926533	+	Missense_Mutation	SNP	G	G	C			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr19:49926533G>C	ENST00000270631.1	-	1	165	c.64C>G	c.(64-66)Ctg>Gtg	p.L22V		NM_178449.3	NP_848544.1	Q96A98	TIP39_HUMAN	parathyroid hormone 2	22					neuropeptide signaling pathway	extracellular region		p.L22V(2)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(262;0.0015)|GBM - Glioblastoma multiforme(486;0.044)|Lung(386;0.0785)|LUSC - Lung squamous cell carcinoma(496;0.0836)		GGCACCACcagcagcagcagc	0.692000													4	36					0	0	1	0	0
ANKRD35	148741	broad.mit.edu	37	1	145561563	145561563	+	Silent	SNP	T	T	C			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr1:145561563T>C	ENST00000355594.4	+	10	1338	c.1251T>C	c.(1249-1251)caT>caC	p.H417H		NM_144698.3	NP_653299.3	Q8N283	ANR35_HUMAN	ankyrin repeat domain 35	417										NS(1)|biliary_tract(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(9)|lung(16)|ovary(4)|prostate(3)|skin(2)|urinary_tract(1)	47	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					ATGAAGTCCATGGAAGGTCCC	0.542000													11	85					0	0	1	0	0
TMPRSS9	360200	broad.mit.edu	37	19	2415714	2415714	+	Silent	SNP	C	C	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr19:2415714C>T	ENST00000332578.3	+	10	1518	c.1518C>T	c.(1516-1518)ggC>ggT	p.G506G		NM_182973.1	NP_892018.1	Q7Z410	TMPS9_HUMAN	transmembrane protease, serine 9	506	Peptidase S1 2.				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGTCGTGGGCGGGTTCGGAG	0.677000													4	50					0	0	1	0	0
DOCK10	55619	broad.mit.edu	37	2	225740797	225740797	+	Missense_Mutation	SNP	G	G	A			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr2:225740797G>A	ENST00000409592.3	-	8	984	c.871C>T	c.(871-873)Ctc>Ttc	p.L291F	DOCK10_ENST00000258390.7_Missense_Mutation_p.L297F			Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	297							GTP binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(10)|large_intestine(16)|lung(40)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	87		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		CTCCCTTGGAGGGGCCCCTCA	0.512000													5	54					0	0	1	0	0
FUZ	80199	broad.mit.edu	37	19	50310533	50310533	+	Missense_Mutation	SNP	C	C	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr19:50310533C>T	ENST00000313777.4	-	11	1295	c.1132G>A	c.(1132-1134)Gtg>Atg	p.V378M	FUZ_ENST00000528094.1_Missense_Mutation_p.V342M|FUZ_ENST00000445575.2_Splice_Site|FUZ_ENST00000533418.1_Missense_Mutation_p.V328M	NM_025129.4	NP_079405.2	Q9BT04	FUZZY_HUMAN	fuzzy planar cell polarity protein	378	Leu-rich.				cilium assembly|embryonic body morphogenesis|embryonic skeletal system morphogenesis|establishment of planar polarity|hair follicle development|neural tube closure|protein transport|regulation of smoothened signaling pathway	cytoplasm|cytoskeleton				endometrium(1)|lung(3)	4		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00793)|GBM - Glioblastoma multiforme(134;0.0116)		ACCAGACGCACTCCTGTGCCT	0.642000													10	47					0	0	1	0	0
PCED1B	91523	broad.mit.edu	37	12	47629097	47629097	+	Missense_Mutation	SNP	C	C	A			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr12:47629097C>A	ENST00000546455.1	+	4	982	c.251C>A	c.(250-252)tCc>tAc	p.S84Y	PCED1B_ENST00000432328.1_Missense_Mutation_p.S84Y					PC-esterase domain containing 1B																		GAGTTCCGCTCCGACCACCAT	0.602000													20	86					8.34094e-07	9.05431e-07	1	1	0
PLD1	5337	broad.mit.edu	37	3	171406534	171406534	+	Missense_Mutation	SNP	C	C	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr3:171406534C>T	ENST00000356327.5	-	14	1541	c.1471G>A	c.(1471-1473)Gag>Aag	p.E491K	PLD1_ENST00000342215.6_Missense_Mutation_p.E491K|PLD1_ENST00000351298.4_Missense_Mutation_p.E491K|PLD1_ENST00000340989.4_Missense_Mutation_p.E491K	NM_001130081.2	NP_001123553.1	Q13393	PLD1_HUMAN	phospholipase D1, phosphatidylcholine-specific	491	Catalytic.				cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(15)|lung(27)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	63	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)	AGTCTGTGCTCATTGTCGTCC	0.502000													8	69					0	0	1	0	0
FKBPL	63943	broad.mit.edu	37	6	32096926	32096926	+	Missense_Mutation	SNP	C	C	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr6:32096926C>T	ENST00000375156.3	-	2	902	c.632G>A	c.(631-633)aGg>aAg	p.R211K		NM_022110.3	NP_071393.2	Q9UIM3	FKBPL_HUMAN	FK506 binding protein like	211					response to radiation	membrane|nucleus	FK506 binding|peptidyl-prolyl cis-trans isomerase activity										ACGTTCTTCCCTGGCCAGGGC	0.602000													22	95					0	0	1	0	0
ITGAV	3685	broad.mit.edu	37	2	187455132	187455132	+	Missense_Mutation	SNP	C	C	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr2:187455132C>T	ENST00000261023.3	+	1	341	c.67C>T	c.(67-69)Ctc>Ttc	p.L23F	ITGAV_ENST00000374907.3_Missense_Mutation_p.L23F	NM_002210.3	NP_002201.1	P06756	ITAV_HUMAN	integrin, alpha V	23					angiogenesis|axon guidance|blood coagulation|cell-matrix adhesion|entry of bacterium into host cell|entry of symbiont into host cell by promotion of host phagocytosis|entry of virus into host cell|ERK1 and ERK2 cascade|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|positive regulation of cell adhesion|positive regulation of cell proliferation|regulation of apoptotic cell clearance	integrin complex	receptor activity|transforming growth factor beta binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47			OV - Ovarian serous cystadenocarcinoma(117;0.0185)|Epithelial(96;0.072)|all cancers(119;0.189)	STAD - Stomach adenocarcinoma(3;0.106)|COAD - Colon adenocarcinoma(31;0.108)		TCTCTCGGGACTCCTGCTACC	0.672000													5	46					0	0	1	0	0
USP21	27005	broad.mit.edu	37	1	161130737	161130737	+	Missense_Mutation	SNP	C	C	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr1:161130737C>T	ENST00000368002.3	+	3	684	c.307C>T	c.(307-309)Cca>Tca	p.P103S	USP21_ENST00000289865.8_Missense_Mutation_p.P103S|USP21_ENST00000368001.1_Missense_Mutation_p.P103S	NM_001014443.2	NP_001014443.1	Q9UK80	UBP21_HUMAN	ubiquitin specific peptidase 21	103					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	nucleus	metal ion binding|NEDD8-specific protease activity|protein binding|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(10)|ovary(3)|prostate(3)	29	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			TTTGCCTCTCCCATCTCGGAC	0.642000													12	65					0	0	1	0	0
FGD1	2245	broad.mit.edu	37	X	54475672	54475672	+	Silent	SNP	C	C	T	rs144498939	byFrequency	TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chrX:54475672C>T	ENST00000375135.3	-	15	2911	c.2178G>A	c.(2176-2178)acG>acA	p.T726T		NM_004463.2	NP_004454.2	P98174	FGD1_HUMAN	FYVE, RhoGEF and PH domain containing 1	726					actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|organ morphogenesis|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|nucleus|plasma membrane|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(10)|lung(8)|ovary(3)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						CCCGGATGGGCGTAGGTGCCC	0.602000													7	20					0	0	1	0	0
PTPRM	5797	broad.mit.edu	37	18	7955231	7955231	+	Silent	SNP	G	G	A			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr18:7955231G>A	ENST00000332175.8	+	7	1988	c.951G>A	c.(949-951)gaG>gaA	p.E317E	PTPRM_ENST00000444013.1_Silent_p.E104E|PTPRM_ENST00000400053.4_Silent_p.E255E|PTPRM_ENST00000400060.4_Silent_p.E317E|PTPRM_ENST00000580170.1_Silent_p.E317E	NM_002845.3	NP_002836.3	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	317	Fibronectin type-III 1.				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(32)|lung(25)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	90		Colorectal(10;0.234)				TGGCCCGAGAGGTGGAGTACT	0.557000													14	43					0	0	1	0	0
MAP3K5	4217	broad.mit.edu	37	6	136926459	136926459	+	Missense_Mutation	SNP	C	C	G			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr6:136926459C>G	ENST00000359015.4	-	19	2927	c.2567G>C	c.(2566-2568)aGa>aCa	p.R856T	MAP3K5_ENST00000355845.4_Missense_Mutation_p.R103T	NM_005923.3	NP_005914.1	Q99683	M3K5_HUMAN	mitogen-activated protein kinase kinase kinase 5	856	Protein kinase.				activation of JUN kinase activity|activation of MAPKK activity|cellular response to hydrogen peroxide|induction of apoptosis by extracellular signals|interspecies interaction between organisms		ATP binding|caspase activator activity|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein phosphatase binding			NS(1)|breast(1)|cervix(1)|endometrium(8)|kidney(6)|large_intestine(6)|lung(24)|ovary(2)|prostate(1)|skin(4)|urinary_tract(4)	58	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00137)|OV - Ovarian serous cystadenocarcinoma(155;0.00569)		TCCGTAGCCTCTTGGTCCTTT	0.413000													22	52					0	0	1	0	0
KIF18B	146909	broad.mit.edu	37	17	43009516	43009516	+	Missense_Mutation	SNP	C	C	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr17:43009516C>T	ENST00000587309.1	-	10	1356	c.1333G>A	c.(1333-1335)Ggg>Agg	p.G445R	KIF18B_ENST00000590129.1_Missense_Mutation_p.G454R|KIF18B_ENST00000438933.2_Missense_Mutation_p.G445R|KIF18B_ENST00000339151.4_Missense_Mutation_p.G445R|KIF18B_ENST00000593135.1_Missense_Mutation_p.G433R	NM_001264573.1	NP_001251503.1			kinesin family member 18B											breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)	21		Prostate(33;0.155)				GCCTCCATCCCCAGACTCTCC	0.642000													10	28					0	0	1	0	0
CPNE7	27132	broad.mit.edu	37	16	89661966	89661966	+	Silent	SNP	G	G	A			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr16:89661966G>A	ENST00000268720.5	+	16	1849	c.1719G>A	c.(1717-1719)gcG>gcA	p.A573A	CPNE7_ENST00000566398.1_3'UTR|CPNE7_ENST00000319518.8_Silent_p.A498A	NM_014427.4	NP_055242.1	Q9UBL6	CPNE7_HUMAN	copine VII	573	VWFA.				lipid metabolic process		transporter activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(2)	17		all_hematologic(23;0.0748)		all cancers(4;3.63e-08)|OV - Ovarian serous cystadenocarcinoma(4;1.7e-06)|BRCA - Breast invasive adenocarcinoma(80;0.0147)		GTGAGCCCGCGCTCCGGGACA	0.662000													9	46					0	0	1	0	0
LOC150776	150776	broad.mit.edu	37	2	132275460	132275460	+	RNA	SNP	A	A	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr2:132275460A>T	ENST00000438378.2	+	0	1733					NR_026922.1																						GATGATTCAGAAAGGTAAGTC	0.617000													3	26					0	0	1	0	0
CHMP4A	29082	broad.mit.edu	37	14	24682710	24682710	+	Missense_Mutation	SNP	G	G	A			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr14:24682710G>A	ENST00000347519.6	-	1	365	c.65C>T	c.(64-66)cCt>cTt	p.P22L	AL136419.6_ENST00000565988.1_RNA	NM_014169.3	NP_054888.2			charged multivesicular body protein 4A											NS(1)|large_intestine(2)|lung(3)|ovary(2)|prostate(1)	9				GBM - Glioblastoma multiforme(265;0.0181)		GCTCCTGGGAGGGTGATGTCT	0.657000													5	49					0	0	1	0	0
ZNF14	7561	broad.mit.edu	37	19	19823218	19823218	+	Missense_Mutation	SNP	A	A	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr19:19823218A>T	ENST00000344099.3	-	4	1010	c.872T>A	c.(871-873)cTc>cAc	p.L291H		NM_021030.2	NP_066358.2	P17017	ZNF14_HUMAN	zinc finger protein 14	291					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|cervix(2)|endometrium(1)|large_intestine(9)|lung(8)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	32		Renal(1328;0.0474)				AAAAGAACTGAGAAAACTGAA	0.388000													4	36					0	0	1	0	0
HIST1H3C	8352	broad.mit.edu	37	6	26045748	26045748	+	Missense_Mutation	SNP	A	A	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr6:26045748A>T	ENST00000540144.1	+	1	110	c.110A>T	c.(109-111)aAg>aTg	p.K37M		NM_003531.2	NP_003522.1	P68431	H31_HUMAN	histone cluster 1, H3c	37					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|ovary(1)|skin(1)	8						GGTGGCGTGAAGAAACCTCAT	0.632000													19	75					0	0	1	0	0
GRID2	2895	broad.mit.edu	37	4	94436372	94436372	+	Missense_Mutation	SNP	T	T	C			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr4:94436372T>C	ENST00000282020.4	+	13	2261	c.2003T>C	c.(2002-2004)cTc>cCc	p.L668P	GRID2_ENST00000510992.1_Missense_Mutation_p.L573P	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	668					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	TCAAGGTCTCTCCAGGACCTT	0.408000													5	21					0	0	1	0	0
MAPK8	5599	broad.mit.edu	37	10	49612966	49612966	+	Missense_Mutation	SNP	C	C	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr10:49612966C>T	ENST00000374189.1	+	3	375	c.194C>T	c.(193-195)aCt>aTt	p.T65I	MAPK8_ENST00000395611.3_Missense_Mutation_p.T65I|MAPK8_ENST00000360332.3_Missense_Mutation_p.T65I|MAPK8_ENST00000374174.1_Missense_Mutation_p.T65I|MAPK8_ENST00000374182.3_Missense_Mutation_p.T65I			P45983	MK08_HUMAN	mitogen-activated protein kinase 8	65	Protein kinase.				activation of pro-apoptotic gene products|cellular response to mechanical stimulus|induction of apoptosis by intracellular signals|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of apoptosis|negative regulation of protein binding|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of deacetylase activity|regulation of protein localization|regulation of sequence-specific DNA binding transcription factor activity|response to UV|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|histone deacetylase binding|histone deacetylase regulator activity|JUN kinase activity|protein binding			breast(1)|central_nervous_system(3)|endometrium(4)|kidney(1)|large_intestine(6)|liver(3)|lung(11)|ovary(1)|skin(1)|stomach(1)|urinary_tract(2)	34		Ovarian(717;0.0221)|Lung SC(717;0.113)|all_neural(218;0.116)		Epithelial(53;3.46e-65)|Lung(62;0.125)		CAGAATCAGACTCATGCCAAG	0.358000													5	37					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103237105	103237105	+	Missense_Mutation	SNP	C	C	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr7:103237105C>T	ENST00000428762.1	-	25	3496	c.3337G>A	c.(3337-3339)Ggg>Agg	p.G1113R	RELN_ENST00000343529.5_Missense_Mutation_p.G1113R|RELN_ENST00000424685.2_Missense_Mutation_p.G1113R	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	1113					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TGTCTTTTCCCAGCCTTTCAG	0.433000													10	52					0	0	1	0	0
CAPN15	6650	broad.mit.edu	37	16	603477	603477	+	Silent	SNP	G	G	A	rs149989399	byFrequency	TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr16:603477G>A	ENST00000219611.2	+	14	3585	c.3222G>A	c.(3220-3222)acG>acA	p.T1074T	LA16c-366D1.3_ENST00000565879.1_RNA	NM_005632.2	NP_005623.1			calpain 15																		CCCCACTCACGCCAGAGGTCG	0.677000													7	73					0	0	1	0	0
KCNH7	90134	broad.mit.edu	37	2	163695001	163695001	+	Missense_Mutation	SNP	G	G	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr2:163695001G>T	ENST00000332142.5	-	1	127	c.28C>A	c.(28-30)Cca>Aca	p.P10T	KCNH7_ENST00000328032.4_Missense_Mutation_p.P10T	NM_033272.3	NP_150375.2	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 7	10					regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(22)|lung(53)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	108					Ibutilide(DB00308)	GTATTTTGTGGTGCCACATGC	0.562000													9	65					4.84862e-15	5.55571e-15	1	1	0
PI4KB	5298	broad.mit.edu	37	1	151278751	151278751	+	Missense_Mutation	SNP	C	C	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr1:151278751C>T	ENST00000368875.2	-	6	1887	c.1307G>A	c.(1306-1308)cGg>cAg	p.R436Q	PI4KB_ENST00000271657.5_Missense_Mutation_p.R436Q|PI4KB_ENST00000529142.1_Missense_Mutation_p.R92Q|PI4KB_ENST00000368872.1_Missense_Mutation_p.R409Q|PI4KB_ENST00000368873.1_Missense_Mutation_p.R424Q|PI4KB_ENST00000368874.4_Missense_Mutation_p.R409Q	NM_002651.2	NP_002642.1	Q9UBF8	PI4KB_HUMAN	phosphatidylinositol 4-kinase, catalytic, beta	424					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|receptor-mediated endocytosis	endosome|Golgi apparatus|mitochondrial outer membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum membrane	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			breast(3)|endometrium(5)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	27	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			CCTCGTACTCCGAATTCGGTT	0.527000													13	50					0	0	1	0	0
OGDHL	55753	broad.mit.edu	37	10	50944522	50944522	+	Missense_Mutation	SNP	G	G	A			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr10:50944522G>A	ENST00000374103.4	-	21	2720	c.2635C>T	c.(2635-2637)Cgg>Tgg	p.R879W	OGDHL_ENST00000419399.1_Missense_Mutation_p.R822W|OGDHL_ENST00000432695.1_Missense_Mutation_p.R670W|OGDHL_ENST00000490844.1_5'UTR	NM_018245.2	NP_060715.2	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like	879					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	61						TCAGGGGCCCGTGCTGCGGCC	0.637000													4	125					0	0	1	0	0
ABCA12	26154	broad.mit.edu	37	2	215840595	215840595	+	Silent	SNP	G	G	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr2:215840595G>T	ENST00000272895.7	-	34	5514	c.5295C>A	c.(5293-5295)ggC>ggA	p.G1765G	ABCA12_ENST00000389661.4_Silent_p.G1447G	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	1765					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		TTCTCAGTGTGCCAAGGCCCA	0.488000													21	101					2.4624e-09	2.74524e-09	1	1	0
WDR90	197335	broad.mit.edu	37	16	716723	716723	+	Silent	SNP	G	G	A			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr16:716723G>A	ENST00000549091.1	+	39	5033	c.4941G>A	c.(4939-4941)ggG>ggA	p.G1647G	WDR90_ENST00000547944.1_Silent_p.G244G|WDR90_ENST00000315764.4_Silent_p.G196G|WDR90_ENST00000293879.4_Silent_p.G1645G|WDR90_ENST00000547543.1_3'UTR	NM_145294.4	NP_660337.3	Q96KV7	WDR90_HUMAN	WD repeat domain 90	1645										endometrium(4)|kidney(3)|large_intestine(2)|lung(22)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	37		Hepatocellular(780;0.0218)				CTTGGGATGGGGCGCTCCTGA	0.647000													19	67					0	0	1	0	0
CLUH	23277	broad.mit.edu	37	17	2600086	2600086	+	Silent	SNP	C	C	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr17:2600086C>T	ENST00000570628.1	-	11	2103	c.1998G>A	c.(1996-1998)gaG>gaA	p.E666E	CLUH_ENST00000538975.1_Silent_p.E666E|CLUH_ENST00000435359.1_Silent_p.E666E|CLUH_ENST00000575014.1_Silent_p.E598E					clustered mitochondria (cluA/CLU1) homolog																		TGCTACCCTCCTCCTCACTTC	0.652000													17	41					0	0	1	0	0
DNAJA2	10294	broad.mit.edu	37	16	47005331	47005331	+	Missense_Mutation	SNP	C	C	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr16:47005331C>T	ENST00000317089.5	-	3	507	c.292G>A	c.(292-294)Ggc>Agc	p.G98S		NM_005880.3	NP_005871.1	O60884	DNJA2_HUMAN	DnaJ (Hsp40) homolog, subfamily A, member 2	98					positive regulation of cell proliferation|protein folding|response to heat	membrane	ATP binding|heat shock protein binding|metal ion binding|unfolded protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|prostate(2)|upper_aerodigestive_tract(1)	14		all_cancers(37;0.00125)|all_lung(18;0.00338)|all_epithelial(9;0.00358)|Lung NSC(13;0.0309)|Breast(268;0.116)				CCCATGAAGCCGAACAATCCC	0.448000													20	125					0	0	1	0	0
MUC6	4588	broad.mit.edu	37	11	1028255	1028255	+	Missense_Mutation	SNP	G	G	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr11:1028255G>T	ENST00000421673.2	-	14	1774	c.1724C>A	c.(1723-1725)aCt>aAt	p.T575N		NM_005961.2	NP_005952.2	Q6W4X9	MUC6_HUMAN	mucin 6, oligomeric mucus/gel-forming	575	VWFD 2.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(8)|kidney(10)|large_intestine(6)|lung(43)|ovary(4)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	80		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GCAGGGGTCAGTCTCACGCTC	0.667000													3	17					0.00909568	0.00915114	1	1	0
EPHA10	284656	broad.mit.edu	37	1	38227628	38227628	+	Missense_Mutation	SNP	C	C	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr1:38227628C>T	ENST00000373048.4	-	3	298	c.299G>A	c.(298-300)cGc>cAc	p.R100H	EPHA10_ENST00000319637.6_Missense_Mutation_p.R100H|EPHA10_ENST00000427468.2_Missense_Mutation_p.R100H	NM_001099439.1	NP_001092909.1	Q5JZY3	EPHAA_HUMAN	EPH receptor A10	100						extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			NS(2)|breast(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(4)|lung(13)|prostate(3)|skin(8)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CACGAAGATGCGCTGCCCGCG	0.607000													4	165					0	0	1	0	0
GPX1	2876	broad.mit.edu	37	3	49395482	49395482	+	Missense_Mutation	SNP	G	G	C			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr3:49395482G>C	ENST00000419783.1	-	1	551	c.230C>G	c.(229-231)cCg>cGg	p.P77R	GPX1_ENST00000419349.1_Missense_Mutation_p.P77R|GPX1_ENST00000496791.1_5'UTR	NM_000581.2	NP_000572.2	P07203	GPX1_HUMAN	glutathione peroxidase 1	77					anti-apoptosis|cell redox homeostasis|glutathione metabolic process|heart contraction|hydrogen peroxide catabolic process|negative regulation of caspase activity|purine base metabolic process|purine nucleotide catabolic process|regulation of gene expression, epigenetic|regulation of mammary gland epithelial cell proliferation|regulation of proteasomal protein catabolic process|release of cytochrome c from mitochondria|response to selenium ion|UV protection	cytosol|mitochondrion	endopeptidase inhibitor activity|glutathione peroxidase activity|SH3 domain binding			breast(1)|large_intestine(2)|lung(1)	4				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	Glutathione(DB00143)	CTGGTTGCACGGGAAGCCGAG	0.726000													3	19					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414343	20414343	+	Silent	SNP	A	A	G			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr9:20414343A>G	ENST00000380338.4	-	5	787	c.501T>C	c.(499-501)agT>agC	p.S167S	MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S164S	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	167	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S167S(19)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctactgctgctgc	0.532000			T	MLL	ALL								5	73					0	0	1	0	0
ASXL2	55252	broad.mit.edu	37	2	25966250	25966250	+	Missense_Mutation	SNP	C	C	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr2:25966250C>T	ENST00000435504.4	-	13	3249	c.2956G>A	c.(2956-2958)Gag>Aag	p.E986K	ASXL2_ENST00000336112.4_Missense_Mutation_p.E958K|ASXL2_ENST00000404843.1_Intron|ASXL2_ENST00000272341.4_Intron			Q76L83	ASXL2_HUMAN	additional sex combs like 2 (Drosophila)	986					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(7)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(3)	33	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCCCTTTCCTCTTTTGCAGTC	0.478000													11	109					0	0	1	0	0
TXLNA	200081	broad.mit.edu	37	1	32647005	32647005	+	Missense_Mutation	SNP	A	A	G			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr1:32647005A>G	ENST00000373609.1	+	2	613	c.332A>G	c.(331-333)gAg>gGg	p.E111G	TXLNA_ENST00000373610.3_Missense_Mutation_p.E111G			P40222	TXLNA_HUMAN	taxilin alpha	111					cell proliferation|exocytosis	cytoplasm|extracellular region	cytokine activity|high molecular weight B cell growth factor receptor binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(2)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	13		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				GAAGATGCAGAGAAGTCCCGG	0.567000													7	28					0	0	1	0	0
INCENP	3619	broad.mit.edu	37	11	61897977	61897977	+	Silent	SNP	C	C	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr11:61897977C>T	ENST00000394818.3	+	4	1180	c.978C>T	c.(976-978)gcC>gcT	p.A326A	INCENP_ENST00000278849.4_Silent_p.A326A	NM_001040694.1	NP_001035784.1	Q9NQS7	INCE_HUMAN	inner centromere protein antigens 135/155kDa	326					chromosome segregation|cytokinesis|mitotic prometaphase	centromeric heterochromatin|condensed chromosome kinetochore|cytosol|microtubule|spindle	protein binding			breast(1)|endometrium(1)|kidney(6)|large_intestine(2)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	19						CTCTGGTGGCCAAACAGGAAA	0.622000													17	104					0	0	1	0	0
GATA3	2625	broad.mit.edu	37	10	8106031	8106031	+	Missense_Mutation	SNP	G	G	A			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr10:8106031G>A	ENST00000379328.3	+	4	1422	c.854G>A	c.(853-855)tGc>tAc	p.C285Y	GATA3_ENST00000346208.3_Missense_Mutation_p.C284Y|GATA3_ENST00000461472.1_Intron	NM_001002295.1|NM_002051.2	NP_001002295.1|NP_002042.1	P23771	GATA3_HUMAN	GATA binding protein 3	284				NA -> RR (in Ref. 4; AAA35870).	aortic valve morphogenesis|blood coagulation|canonical Wnt receptor signaling pathway involved in metanephric kidney development|cardiac right ventricle morphogenesis|cell fate determination|cellular response to interferon-alpha|cellular response to interleukin-4|cellular response to tumor necrosis factor|defense response|ear development|lymphocyte migration|male gonad development|mesenchymal to epithelial transition|mesonephros development|negative regulation of cell cycle|negative regulation of cell motility|negative regulation of cell proliferation involved in mesonephros development|negative regulation of endothelial cell apoptosis|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation|negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation|negative regulation of inflammatory response|negative regulation of mammary gland epithelial cell proliferation|nephric duct formation|norepinephrine biosynthetic process|pharyngeal system development|phosphatidylinositol 3-kinase cascade|positive regulation of endothelial cell migration|positive regulation of interleukin-13 secretion|positive regulation of interleukin-4 production|positive regulation of interleukin-5 secretion|positive regulation of protein kinase B signaling cascade|positive regulation of T cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|positive regulation of ureteric bud formation|regulation of cellular response to X-ray|regulation of cytokine biosynthetic process|regulation of nephron tubule epithelial cell differentiation|response to estrogen stimulus|response to virus|sympathetic nervous system development|T cell receptor signaling pathway|TOR signaling cascade|ureteric bud formation|uterus development|ventricular septum development	nuclear chromatin|nucleolus|nucleoplasm	core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|E-box binding|HMG box domain binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription coactivator activity|transcription factor binding|zinc ion binding			NS(1)|breast(44)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(24)|ovary(3)|skin(2)	87						CACTACCTGTGCAACGCCTGC	0.567000			"""F, N, S"""		breast		"""HDR syndrome (HYPOPARATHYROIDISM, SENSORINEURAL DEAFNESS, AND RENAL DISEASE)"""						18	108					0	0	1	0	0
PCCA	5095	broad.mit.edu	37	13	100959482	100959482	+	Missense_Mutation	SNP	A	A	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr13:100959482A>T	ENST00000376285.1	+	15	1359	c.1321A>T	c.(1321-1323)Att>Ttt	p.I441F	PCCA_ENST00000376279.3_Missense_Mutation_p.I441F|PCCA_ENST00000376286.4_Missense_Mutation_p.I415F	NM_000282.3	NP_000273.2	P05165	PCCA_HUMAN	propionyl CoA carboxylase, alpha polypeptide	441	Biotin carboxylation.				fatty acid beta-oxidation	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|enzyme binding|metal ion binding|propionyl-CoA carboxylase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(12)|lung(8)|prostate(1)|skin(2)	26	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Biotin(DB00121)	AGGAAGTGATATTAGCATTTA	0.299000													8	27					0	0	1	0	0
LOC150776	150776	broad.mit.edu	37	2	132275459	132275459	+	RNA	SNP	G	G	A			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr2:132275459G>A	ENST00000438378.2	+	0	1732					NR_026922.1																						AGATGATTCAGAAAGGTAAGT	0.612000													3	26					0	0	1	0	0
CHML	1122	broad.mit.edu	37	1	241799085	241799085	+	Translation_Start_Site	SNP	G	G	A	rs140161557	by1000genomes	TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr1:241799085G>A	ENST00000366553.1	-	0	147				OPN3_ENST00000366554.2_Intron|OPN3_ENST00000331838.5_Intron|OPN3_ENST00000469376.1_Intron	NM_001821.3	NP_001812.2	P26374	RAE2_HUMAN	choroideremia-like (Rab escort protein 2)						intracellular protein transport|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(6)|lung(7)|ovary(4)|skin(3)|stomach(1)	26	Ovarian(103;0.103)|all_lung(81;0.23)	all_cancers(173;0.0231)	OV - Ovarian serous cystadenocarcinoma(106;0.0125)			AAGTAACAGCGTCTGGTGACA	0.438000													7	48					0	0	1	0	0
PHC2	1912	broad.mit.edu	37	1	33832911	33832911	+	Missense_Mutation	SNP	G	G	A			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr1:33832911G>A	ENST00000257118.5	-	6	835	c.782C>T	c.(781-783)cCt>cTt	p.P261L	PHC2_ENST00000431992.1_Missense_Mutation_p.P232L|PHC2_ENST00000373416.1_5'UTR|PHC2_ENST00000419414.2_Missense_Mutation_p.P261L	NM_198040.2	NP_932157.1	Q8IXK0	PHC2_HUMAN	polyhomeotic homolog 2 (Drosophila)	261					multicellular organismal development	PcG protein complex	DNA binding|identical protein binding|zinc ion binding			autonomic_ganglia(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|liver(1)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	31		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				GGTAGGCAGAGGCTGGCTACC	0.637000											OREG0013344	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	134					0	0	1	0	0
SHOC2	8036	broad.mit.edu	37	10	112724466	112724466	+	Nonsense_Mutation	SNP	C	C	A			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr10:112724466C>A	ENST00000369452.4	+	2	695	c.350C>A	c.(349-351)tCa>tAa	p.S117*	SHOC2_ENST00000265277.5_Nonsense_Mutation_p.S117*|SHOC2_ENST00000489390.1_Intron	NM_007373.3	NP_031399.2	Q9UQ13	SHOC2_HUMAN	soc-2 suppressor of clear homolog (C. elegans)	117					fibroblast growth factor receptor signaling pathway|positive regulation of Ras protein signal transduction|Ras protein signal transduction	nucleus|protein phosphatase type 1 complex	protein phosphatase binding|protein phosphatase regulator activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(4)|ovary(1)|skin(2)	17				Epithelial(162;0.000796)|all cancers(201;0.011)|BRCA - Breast invasive adenocarcinoma(275;0.126)		ATATTGCCATCATCAATCAAA	0.383000													7	89					0.248553	0.248553	1	1	0
NPR1	4881	broad.mit.edu	37	1	153655867	153655867	+	Missense_Mutation	SNP	A	A	C			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr1:153655867A>C	ENST00000368680.3	+	6	1751	c.1279A>C	c.(1279-1281)Aat>Cat	p.N427H		NM_000906.3	NP_000897.3	P16066	ANPRA_HUMAN	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	427					body fluid secretion|intracellular signal transduction|negative regulation of angiogenesis|negative regulation of cell growth|positive regulation of renal sodium excretion|positive regulation of urine volume|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size|regulation of vascular permeability|regulation of vasodilation		ATP binding|GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|peptide receptor activity, G-protein coupled|protein kinase activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(17)|ovary(4)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	42	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)		Erythrityl Tetranitrate(DB01613)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Nesiritide(DB04899)|Nitric Oxide(DB00435)|Nitroglycerin(DB00727)|Nitroprusside(DB00325)	ACTGAACTACAATGGGACTTC	0.597000													9	42					0	0	1	0	0
PRSS27	83886	broad.mit.edu	37	16	2764296	2764296	+	Missense_Mutation	SNP	C	C	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr16:2764296C>T	ENST00000302641.3	-	4	332	c.278G>A	c.(277-279)aGg>aAg	p.R93K		NM_031948.3	NP_114154.1	Q9BQR3	PRS27_HUMAN	protease, serine 27	93	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)	8						CACTAGCTGCCTTGCCCCCAG	0.692000													3	14					0	0	1	0	0
TACC1	6867	broad.mit.edu	37	8	38677367	38677367	+	Missense_Mutation	SNP	G	G	A			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr8:38677367G>A	ENST00000379931.3	+	3	984	c.605G>A	c.(604-606)gGg>gAg	p.G202E	TACC1_ENST00000520973.1_Missense_Mutation_p.G7E|TACC1_ENST00000519416.1_Missense_Mutation_p.G7E|TACC1_ENST00000330691.6_Intron|TACC1_ENST00000520615.1_Missense_Mutation_p.G7E|TACC1_ENST00000520340.1_Missense_Mutation_p.G166E|TACC1_ENST00000348567.4_Intron|TACC1_ENST00000317827.4_Missense_Mutation_p.G202E|TACC1_ENST00000522752.1_Intron|TACC1_ENST00000443286.2_Missense_Mutation_p.G218E|TACC1_ENST00000276520.8_Intron|TACC1_ENST00000518415.1_Missense_Mutation_p.G157E			O75410	TACC1_HUMAN	transforming, acidic coiled-coil containing protein 1	202	Interaction with TDRD7.				cell cycle|cell division	intermediate filament cytoskeleton|microtubule organizing center|nucleus	protein binding			breast(4)|endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|skin(3)	17		all_lung(54;0.00292)|Lung NSC(58;0.0115)|Hepatocellular(245;0.065)	LUSC - Lung squamous cell carcinoma(45;1.7e-09)|COAD - Colon adenocarcinoma(9;0.235)			GGCAGCATGGGGGTCACCCTC	0.592000													4	126					0	0	1	0	0
TCF12	6938	broad.mit.edu	37	15	57545575	57545575	+	Missense_Mutation	SNP	T	T	C			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr15:57545575T>C	ENST00000267811.5	+	15	1608	c.1304T>C	c.(1303-1305)tTa>tCa	p.L435S	TCF12_ENST00000557843.1_Missense_Mutation_p.L435S|TCF12_ENST00000537840.1_Missense_Mutation_p.L199S|TCF12_ENST00000438423.2_Missense_Mutation_p.L459S|TCF12_ENST00000543579.1_Missense_Mutation_p.L289S|TCF12_ENST00000343827.3_Missense_Mutation_p.L265S|TCF12_ENST00000452095.2_Missense_Mutation_p.L455S|TCF12_ENST00000559703.1_Missense_Mutation_p.L93S|TCF12_ENST00000560764.1_3'UTR|TCF12_ENST00000333725.5_Missense_Mutation_p.L459S|TCF12_ENST00000559710.1_Missense_Mutation_p.L69S	NM_003205.3|NM_207038.1	NP_003196.1|NP_996921.1	Q99081	HTF4_HUMAN	transcription factor 12	435					immune response|muscle organ development|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity		TCF12/NR4A3(2)	breast(2)|central_nervous_system(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(1)|lung(13)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	36		Colorectal(260;0.0907)		all cancers(107;0.000313)|GBM - Glioblastoma multiforme(80;0.00878)|STAD - Stomach adenocarcinoma(283;0.239)		ATACATAGTTTATTGGGACCA	0.458000			T	TEC	extraskeletal myxoid chondrosarcoma								8	71					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124414967	124414967	+	Missense_Mutation	SNP	G	G	A			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr12:124414967G>A	ENST00000409039.3	+	72	12302	c.12277G>A	c.(12277-12279)Gcc>Acc	p.A4093T	CCDC92_ENST00000544798.1_Intron|DNAH10OS_ENST00000514254.2_3'UTR	NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	4093					microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TGGAGGACGGGCCATCGACAG	0.562000													3	29					0	0	1	0	0
WDR90	197335	broad.mit.edu	37	16	711364	711364	+	Missense_Mutation	SNP	G	G	A			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr16:711364G>A	ENST00000549091.1	+	30	3628	c.3536G>A	c.(3535-3537)cGa>cAa	p.R1179Q	WDR90_ENST00000293879.4_Missense_Mutation_p.R1179Q	NM_145294.4	NP_660337.3	Q96KV7	WDR90_HUMAN	WD repeat domain 90	1179										endometrium(4)|kidney(3)|large_intestine(2)|lung(22)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	37		Hepatocellular(780;0.0218)				GCCTCGGGCCGAAGCAGCACG	0.682000													11	42					0	0	1	0	0
CLTCL1	8218	broad.mit.edu	37	22	19188854	19188854	+	Missense_Mutation	SNP	G	G	A			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr22:19188854G>A	ENST00000263200.10	-	23	3823	c.3751C>T	c.(3751-3753)Cgg>Tgg	p.R1251W	CLTCL1_ENST00000427926.1_Missense_Mutation_p.R1251W|CLTCL1_ENST00000353891.5_Missense_Mutation_p.R1251W|CLTCL1_ENST00000442042.2_5'UTR	NM_007098.3	NP_009029.3	P53675	CLH2_HUMAN	clathrin, heavy chain-like 1	1251	Heavy chain arm.|Involved in binding clathrin light chain (By similarity).|Proximal segment.				anatomical structure morphogenesis|intracellular protein transport|mitosis|positive regulation of glucose import|receptor-mediated endocytosis	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|spindle|trans-Golgi network	protein binding|signal transducer activity|structural molecule activity			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(9)|kidney(3)|large_intestine(11)|lung(9)|ovary(5)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49	Colorectal(54;0.0993)					TTCCACGTCCGGGTGCTGCTG	0.592000			T	?	ALCL								5	24					0	0	1	0	0
SLCO1C1	53919	broad.mit.edu	37	12	20868160	20868160	+	Missense_Mutation	SNP	C	C	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr12:20868160C>T	ENST00000381552.1	+	6	985	c.617C>T	c.(616-618)cCt>cTt	p.P206L	SLCO1C1_ENST00000540354.1_Intron|SLCO1C1_ENST00000545604.1_Missense_Mutation_p.P206L|SLCO1C1_ENST00000545102.1_Missense_Mutation_p.P88L|SLCO1C1_ENST00000266509.2_Missense_Mutation_p.P206L			Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family, member 1C1	206					sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			NS(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	60	Esophageal squamous(101;0.149)					CCCATTCAGCCTTTGGGCATT	0.418000													12	117					0	0	1	0	0
KIF23	9493	broad.mit.edu	37	15	69718764	69718764	+	Missense_Mutation	SNP	C	C	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr15:69718764C>T	ENST00000260363.4	+	9	1054	c.937C>T	c.(937-939)Ccc>Tcc	p.P313S	KIF23_ENST00000558585.1_Missense_Mutation_p.P130S|KIF23_ENST00000395392.2_Missense_Mutation_p.P313S|KIF23_ENST00000559279.1_Missense_Mutation_p.P313S|KIF23_ENST00000352331.4_Missense_Mutation_p.P313S|KIF23_ENST00000537891.1_Missense_Mutation_p.P130S	NM_138555.2	NP_612565.1	Q02241	KIF23_HUMAN	kinesin family member 23	313	Kinesin-motor.				blood coagulation|cytokinesis|microtubule-based movement|mitosis|mitotic spindle elongation	cytosol|kinesin complex|microtubule|midbody|nucleoplasm|spindle	ATP binding|microtubule motor activity|protein binding			central_nervous_system(1)|endometrium(4)|large_intestine(7)|lung(6)|prostate(2)|skin(1)	21						AGTTCAGGCTCCCTTGGATGC	0.398000													35	161					0	0	1	0	0
SCNN1B	6338	broad.mit.edu	37	16	23364284	23364284	+	Silent	SNP	C	C	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr16:23364284C>T	ENST00000343070.2	+	3	650	c.474C>T	c.(472-474)ccC>ccT	p.P158P	SCNN1B_ENST00000568085.1_Silent_p.P158P|SCNN1B_ENST00000307331.5_Silent_p.P203P|SCNN1B_ENST00000568923.1_Silent_p.P158P	NM_000336.2	NP_000327.2	P51168	SCNNB_HUMAN	sodium channel, non-voltage-gated 1, beta subunit	158					excretion|sensory perception of taste	apical plasma membrane	ligand-gated sodium channel activity|WW domain binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|liver(2)|lung(8)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	32				GBM - Glioblastoma multiforme(48;0.0465)	Amiloride(DB00594)|Triamterene(DB00384)	AACGGAACCCCCACCACCCCA	0.517000													14	133					0	0	1	0	0
SPRED2	200734	broad.mit.edu	37	2	65541047	65541047	+	Missense_Mutation	SNP	C	C	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr2:65541047C>T	ENST00000356388.4	-	6	1034	c.845G>A	c.(844-846)gGc>gAc	p.G282D	SPRED2_ENST00000443619.2_Missense_Mutation_p.G279D	NM_181784.2	NP_861449.2	Q7Z698	SPRE2_HUMAN	sprouty-related, EVH1 domain containing 2	282					inactivation of MAPK activity|multicellular organismal development	transport vesicle membrane	stem cell factor receptor binding			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(7)|ovary(2)|upper_aerodigestive_tract(3)	34						GCCCCCGCGGCCTTTGGGGTC	0.662000													26	88					0	0	1	0	0
TMEM190	147744	broad.mit.edu	37	19	55889217	55889217	+	Missense_Mutation	SNP	G	G	A			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr19:55889217G>A	ENST00000291934.3	+	4	286	c.268G>A	c.(268-270)Ggc>Agc	p.G90S	CTD-2105E13.15_ENST00000595064.1_RNA	NM_139172.1	NP_631911.1	Q8WZ59	TM190_HUMAN	transmembrane protein 190	90						integral to membrane				large_intestine(1)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	5	Breast(117;0.191)		BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		GACGTGCAGCGGCCTCCTCCT	0.697000													9	63					0	0	1	0	0
GRK7	131890	broad.mit.edu	37	3	141497350	141497350	+	Missense_Mutation	SNP	C	C	A			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr3:141497350C>A	ENST00000264952.2	+	1	361	c.224C>A	c.(223-225)gCc>gAc	p.A75D		NM_139209.2	NP_631948.1	Q8WTQ7	GRK7_HUMAN	G protein-coupled receptor kinase 7	75	RGS.				visual perception	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(14)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	26						GACTTCCTAGCCACAGTGCCC	0.657000													12	51					3.07112e-06	3.29048e-06	1	1	0
DGKZ	8525	broad.mit.edu	37	11	46394044	46394044	+	Nonsense_Mutation	SNP	G	G	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr11:46394044G>T	ENST00000454345.1	+	12	1683	c.1558G>T	c.(1558-1560)Gga>Tga	p.G520*	DGKZ_ENST00000528615.1_Nonsense_Mutation_p.G110*|DGKZ_ENST00000543978.1_Intron|DGKZ_ENST00000456247.2_Nonsense_Mutation_p.G331*|DGKZ_ENST00000527911.1_Nonsense_Mutation_p.G332*|DGKZ_ENST00000532868.2_Nonsense_Mutation_p.G336*|DGKZ_ENST00000343674.6_Nonsense_Mutation_p.G348*|DGKZ_ENST00000421244.2_Nonsense_Mutation_p.G332*|DGKZ_ENST00000318201.8_Nonsense_Mutation_p.G309*|DGKZ_ENST00000395574.3_Nonsense_Mutation_p.G298*	NM_001105540.1	NP_001099010.1	Q13574	DGKZ_HUMAN	diacylglycerol kinase, zeta	520	DAGKc.|Mediates interaction with RASGRP1.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell migration|intracellular signal transduction|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of mitotic cell cycle|platelet activation	cytoplasm|lamellipodium|nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|lipid kinase activity|metal ion binding|protein binding|protein C-terminus binding			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(12)|pancreas(1)|prostate(1)|skin(1)	25				GBM - Glioblastoma multiforme(35;0.0259)|Lung(87;0.141)		CCTGAGCCAGGGAGGGCCCAA	0.582000													13	71					4.36969e-10	4.90475e-10	1	1	0
DDO	8528	broad.mit.edu	37	6	110714266	110714266	+	Silent	SNP	C	C	A	rs148812598	byFrequency	TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr6:110714266C>A	ENST00000368924.3	-	5	837	c.822G>T	c.(820-822)ccG>ccT	p.P274P	DDO_ENST00000368925.1_Silent_p.P246P|DDO_ENST00000368923.3_Silent_p.P215P	NM_003649.2	NP_003640.2	Q99489	OXDD_HUMAN	D-aspartate oxidase	246					aspartate catabolic process	peroxisome	binding|D-amino-acid oxidase activity|D-aspartate oxidase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(9)|ovary(4)|pancreas(1)|skin(3)	24		all_cancers(87;3.47e-21)|all_epithelial(87;9.03e-20)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_lung(197;2.98e-05)|Lung NSC(302;3.25e-05)|Colorectal(196;3.46e-05)|Ovarian(999;0.00327)		all cancers(137;2.54e-48)|Epithelial(106;3.11e-44)|OV - Ovarian serous cystadenocarcinoma(136;2.08e-24)|BRCA - Breast invasive adenocarcinoma(108;0.000141)|GBM - Glioblastoma multiforme(226;0.00046)		TTTCTGCATCCGGGGACAGAT	0.522000													32	171					2.80507e-11	3.17012e-11	1	1	0
ZNF208	7757	broad.mit.edu	37	19	22154756	22154756	+	Missense_Mutation	SNP	G	G	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr19:22154756G>T	ENST00000397126.4	-	4	3228	c.3080C>A	c.(3079-3081)aCa>aAa	p.T1027K	ZNF208_ENST00000599916.1_Intron|ZNF208_ENST00000601773.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				TTTGTAGGGTGTCTCTCCAGT	0.413000													7	81					0.000274275	0.000286427	1	1	0
PPFIA4	8497	broad.mit.edu	37	1	203028956	203028956	+	Missense_Mutation	SNP	C	C	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr1:203028956C>T	ENST00000367240.2	+	20	3024	c.2497C>T	c.(2497-2499)Cct>Tct	p.P833S	PPFIA4_ENST00000414050.2_Missense_Mutation_p.P561S|PPFIA4_ENST00000447715.2_Missense_Mutation_p.P832S|PPFIA4_ENST00000599966.1_Missense_Mutation_p.P348S|PPFIA4_ENST00000272198.6_Missense_Mutation_p.P348S|PPFIA4_ENST00000295706.4_Missense_Mutation_p.P348S			O75335	LIPA4_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4	348					cell communication	cell surface|cytoplasm	protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|endometrium(6)|kidney(2)|large_intestine(8)|lung(20)|ovary(4)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	50						GTGGGATGGTCCTACTGTGGT	0.552000													7	11					0	0	1	0	0
RASA4B	100271927	broad.mit.edu	37	7	102136604	102136604	+	Missense_Mutation	SNP	C	C	T	rs746316		TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr7:102136604C>T	ENST00000481893.1	-	16	1962	c.838G>A	c.(838-840)Gtg>Atg	p.V280M	RASA4B_ENST00000306682.6_Missense_Mutation_p.V280M|RASA4B_ENST00000465829.1_Missense_Mutation_p.V352M|RASA4B_ENST00000541662.1_Missense_Mutation_p.V352M					RAS p21 protein activator 4B									p.V352M(1)		skin(1)	1						AAAGACTCCACGGACTTTGAG	0.542000													4	103					0	0	1	0	0
COL26A1	136227	broad.mit.edu	37	7	101188672	101188672	+	RNA	SNP	G	G	A			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr7:101188672G>A	ENST00000313669.7	+	0	949				COL26A1_ENST00000528707.1_RNA|COL26A1_ENST00000397927.3_RNA	NM_133457.2	NP_597714.2			collagen, type XXVI, alpha 1																		GGGGCGCCCCGGCCCCCCAGG	0.697000													6	23					0	0	1	0	0
PIGK	10026	broad.mit.edu	37	1	77620301	77620301	+	Missense_Mutation	SNP	C	C	A			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr1:77620301C>A	ENST00000370812.3	-	9	842	c.819G>T	c.(817-819)caG>caT	p.Q273H	PIGK_ENST00000478391.1_5'UTR|PIGK_ENST00000445065.1_Missense_Mutation_p.Q179H|PIGK_ENST00000359130.1_Missense_Mutation_p.Q273H|PIGK_ENST00000370813.5_Missense_Mutation_p.Q197H	NM_005482.2	NP_005473.1	Q92643	GPI8_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class K	273					attachment of GPI anchor to protein|C-terminal protein lipidation|protein thiol-disulfide exchange|proteolysis	GPI-anchor transamidase complex	cysteine-type endopeptidase activity|GPI-anchor transamidase activity|protein binding			endometrium(5)|kidney(1)|large_intestine(4)|lung(3)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)	19						TGGGACATACCTGAAACTGaa	0.328000													4	16					0.00024832	0.000262646	1	1	0
DNAH1	25981	broad.mit.edu	37	3	52406960	52406960	+	Silent	SNP	C	C	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr3:52406960C>T	ENST00000420323.2	+	44	7137	c.6876C>T	c.(6874-6876)ttC>ttT	p.F2292F		NM_015512.4	NP_056327.4	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	2292	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		TTATCTTCTTCATCGATGACC	0.627000													8	76					0	0	1	0	0
GDF3	9573	broad.mit.edu	37	12	7842781	7842781	+	Missense_Mutation	SNP	A	A	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr12:7842781A>T	ENST00000329913.3	-	2	835	c.788T>A	c.(787-789)cTc>cAc	p.L263H		NM_020634.1	NP_065685.1	Q9NR23	GDF3_HUMAN	growth differentiation factor 3	263					eye development|growth|skeletal system development	extracellular space	cytokine activity|growth factor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(7)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	28						ACGGTGGCAGAGGTTCTTACA	0.542000													18	88					0	0	1	0	0
NOTCH1	4851	broad.mit.edu	37	9	139396814	139396814	+	Missense_Mutation	SNP	C	C	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr9:139396814C>T	ENST00000277541.6	-	28	5369	c.5294G>A	c.(5293-5295)gGc>gAc	p.G1765D		NM_017617.3	NP_060087.3	P46531	NOTC1_HUMAN	notch 1	1765					aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(16)|central_nervous_system(17)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1183)|kidney(4)|large_intestine(1)|lung(57)|oesophagus(2)|ovary(3)|pancreas(1)|prostate(3)|skin(21)|upper_aerodigestive_tract(39)|urinary_tract(3)	1359	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		CCAGAGCTGGCCATGCTGCCG	0.667000			"""T, Mis, O"""	TRB@	T-ALL					HNSCC(8;0.001)			6	30					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149515760	149515760	+	RNA	SNP	C	C	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr7:149515760C>T	ENST00000378016.2	+	0	11661							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GCCCATGGTCCTCCTGGTCCC	0.687000													4	38					0	0	1	0	0
NTNG2	84628	broad.mit.edu	37	9	135073814	135073814	+	Silent	SNP	C	C	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr9:135073814C>T	ENST00000393229.3	+	3	1451	c.675C>T	c.(673-675)ccC>ccT	p.P225P	NTNG2_ENST00000372179.3_Silent_p.P225P|NTNG2_ENST00000360670.3_Silent_p.P225P|NTNG2_ENST00000393228.4_Silent_p.P225P	NM_032536.2	NP_115925.2	Q96CW9	NTNG2_HUMAN	netrin G2	225	Laminin N-terminal.				axonogenesis	anchored to plasma membrane				central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	29				OV - Ovarian serous cystadenocarcinoma(145;1.23e-05)|Epithelial(140;0.000173)		TTGCCGGCCCCGACCTGCGCA	0.662000													21	119					0	0	1	0	0
C2orf16	84226	broad.mit.edu	37	2	27804461	27804461	+	Silent	SNP	C	C	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr2:27804461C>T	ENST00000408964.2	+	1	5073	c.5022C>T	c.(5020-5022)tcC>tcT	p.S1674S		NM_032266.3	NP_115642.3	Q68DN1	CB016_HUMAN	chromosome 2 open reading frame 16	1674	27 X 8 AA approximative tandem repeat of P-S-E-R-S-H-H-S.|Arg-rich.									breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(33)|urinary_tract(1)	47	Acute lymphoblastic leukemia(172;0.155)					GCAGTCCCTCCCAGAGGAGCC	0.572000													14	264					0	0	1	0	0
PCDHA4	56144	broad.mit.edu	37	5	140187569	140187569	+	Missense_Mutation	SNP	C	C	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr5:140187569C>T	ENST00000530339.1	+	1	797	c.797C>T	c.(796-798)gCc>gTc	p.A266V	PCDHA4_ENST00000356878.4_Missense_Mutation_p.A266V|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Missense_Mutation_p.A266V|PCDHA1_ENST00000504120.2_Intron	NM_018907.2	NP_061730.1														breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(6)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAACTTAACGCCTCAGATTTA	0.358000													13	53					0	0	1	0	0
CYTH2	9266	broad.mit.edu	37	19	48981550	48981550	+	Missense_Mutation	SNP	A	A	G			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr19:48981550A>G	ENST00000427476.1	+	10	1207	c.907A>G	c.(907-909)Atc>Gtc	p.I303V	CYTH2_ENST00000452733.2_Missense_Mutation_p.I302V	NM_004228.6|NM_017457.5	NP_004219.3|NP_059431.1	Q99418	CYH2_HUMAN	cytohesin 2	303	PH.				actin cytoskeleton organization|endocytosis|regulation of ARF protein signal transduction|regulation of cell adhesion	cytoplasm|membrane fraction|plasma membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15						GCCCCGAGGAATCATCCCCCT	0.622000													15	87					0	0	1	0	0
ZNF835	90485	broad.mit.edu	37	19	57175629	57175629	+	Missense_Mutation	SNP	G	G	A			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr19:57175629G>A	ENST00000537055.2	-	2	1169	c.938C>T	c.(937-939)gCg>gTg	p.A313V		NM_001005850.2	NP_001005850.2			zinc finger protein 835									p.G334fs*26(1)		endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(22)|pancreas(3)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	47						GCTGAAGAGCGCGCCGCAGTC	0.706000													4	24					0	0	1	0	0
C2orf16	84226	broad.mit.edu	37	2	27804504	27804504	+	Missense_Mutation	SNP	C	C	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr2:27804504C>T	ENST00000408964.2	+	1	5116	c.5065C>T	c.(5065-5067)Ccc>Tcc	p.P1689S		NM_032266.3	NP_115642.3	Q68DN1	CB016_HUMAN	chromosome 2 open reading frame 16	1689	27 X 8 AA approximative tandem repeat of P-S-E-R-S-H-H-S.|Arg-rich.									breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(33)|urinary_tract(1)	47	Acute lymphoblastic leukemia(172;0.155)					CCATTGCAGTCCCTCTGAGAG	0.577000													6	246					0	0	1	0	0
PIK3AP1	118788	broad.mit.edu	37	10	98469699	98469699	+	Missense_Mutation	SNP	C	C	G			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr10:98469699C>G	ENST00000339364.5	-	2	174	c.55G>C	c.(55-57)Gat>Cat	p.D19H		NM_152309.2	NP_689522.2	Q6ZUJ8	BCAP_HUMAN	phosphoinositide-3-kinase adaptor protein 1	19						cytoplasm|plasma membrane				NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(27)|ovary(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	52		Colorectal(252;0.0442)		Epithelial(162;6.29e-08)|all cancers(201;3.18e-06)		TCCTCGGCATCCGGGCTGTAG	0.612000													3	70					0	0	1	0	0
BAZ1A	11177	broad.mit.edu	37	14	35253084	35253084	+	Silent	SNP	T	T	C			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr14:35253084T>C	ENST00000360310.1	-	15	2448	c.1881A>G	c.(1879-1881)ctA>ctG	p.L627L	BAZ1A_ENST00000382422.2_Silent_p.L627L|BAZ1A_ENST00000358716.4_Silent_p.L595L	NM_013448.2	NP_038476.2	Q9NRL2	BAZ1A_HUMAN	bromodomain adjacent to zinc finger domain, 1A	627					chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ACF complex	zinc ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(6)|kidney(2)|large_intestine(7)|lung(19)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	48	Breast(36;0.0388)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;7.23e-05)|Lung(238;0.00019)|Epithelial(34;0.0793)|all cancers(34;0.175)	GBM - Glioblastoma multiforme(112;0.0659)		TAGTTGAAACTAGGGTCAGTA	0.368000													10	58					0	0	1	0	0
RPIA	22934	broad.mit.edu	37	2	88991322	88991322	+	Missense_Mutation	SNP	C	C	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr2:88991322C>T	ENST00000283646.4	+	1	161	c.106C>T	c.(106-108)Ctc>Ttc	p.L36F		NM_144563.2	NP_653164.2	P49247	RPIA_HUMAN	ribose 5-phosphate isomerase A	36					pentose-phosphate shunt, non-oxidative branch	cytosol	ribose-5-phosphate isomerase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(8)|ovary(1)|skin(1)	18		Acute lymphoblastic leukemia(2;0.000456)|all_hematologic(2;0.00287)				CAGCTGGGACCTCCCGGGTTC	0.746000													7	11					0	0	1	0	0
FSIP1	161835	broad.mit.edu	37	15	39909959	39909959	+	Missense_Mutation	SNP	C	C	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr15:39909959C>T	ENST00000350221.3	-	11	1885	c.1676G>A	c.(1675-1677)aGt>aAt	p.S559N		NM_152597.4	NP_689810.3	Q8NA03	FSIP1_HUMAN	fibrous sheath interacting protein 1	559										NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(4)|ovary(2)|skin(4)|stomach(2)|urinary_tract(1)	23		all_cancers(109;2.66e-19)|all_epithelial(112;2.66e-16)|Lung NSC(122;1.5e-11)|all_lung(180;4.03e-10)|Melanoma(134;0.0575)|Ovarian(310;0.0827)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;8.22e-06)|BRCA - Breast invasive adenocarcinoma(123;0.142)		CTCTGGAGAACTGAGTTTCAG	0.393000													10	60					0	0	1	0	0
RALGPS2	55103	broad.mit.edu	37	1	178854232	178854232	+	Missense_Mutation	SNP	C	C	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr1:178854232C>T	ENST00000367635.3	+	12	1264	c.926C>T	c.(925-927)cCa>cTa	p.P309L	RALGPS2_ENST00000367634.2_Missense_Mutation_p.P309L|RALGPS2_ENST00000477383.1_3'UTR|RALGPS2_ENST00000324778.4_Missense_Mutation_p.P274L	NM_152663.3	NP_689876.2	Q86X27	RGPS2_HUMAN	Ral GEF with PH domain and SH3 binding motif 2	309					small GTPase mediated signal transduction	cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity|protein binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(11)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	29						GGAGCGTCTCCACAGAGTGGA	0.433000													8	51					0	0	1	0	0
SPTBN1	6711	broad.mit.edu	37	2	54858010	54858010	+	Silent	SNP	A	A	G			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr2:54858010A>G	ENST00000333896.5	+	15	3172	c.2787A>G	c.(2785-2787)gaA>gaG	p.E929E	SPTBN1_ENST00000356805.4_Silent_p.E942E	NM_178313.2	NP_842565.2	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1	942					actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			NS(1)|breast(8)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(27)|ovary(4)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	82			Lung(47;0.24)			AGTTCAGAGAACTGGTTGACA	0.517000													5	19					0	0	1	0	0
SERPINA1	5265	broad.mit.edu	37	14	94849510	94849510	+	Missense_Mutation	SNP	G	G	A			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr14:94849510G>A	ENST00000448921.1	-	4	637	c.65C>T	c.(64-66)tCc>tTc	p.S22F	SERPINA1_ENST00000393088.4_Missense_Mutation_p.S22F|SERPINA1_ENST00000437397.1_Missense_Mutation_p.S22F|SERPINA1_ENST00000449399.3_Missense_Mutation_p.S22F|SERPINA1_ENST00000355814.4_Missense_Mutation_p.S22F|SERPINA1_ENST00000440909.1_Missense_Mutation_p.S22F|SERPINA1_ENST00000393087.4_Missense_Mutation_p.S22F|SERPINA1_ENST00000402629.1_Missense_Mutation_p.S22F|SERPINA1_ENST00000404814.4_Missense_Mutation_p.S22F	NM_001002236.2|NM_001127701.1|NM_001127703.1|NM_001127704.1|NM_001127705.1	NP_001002236.1|NP_001121173.1|NP_001121175.1|NP_001121176.1|NP_001121177.1	P01009	A1AT_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	22					acute-phase response|platelet activation|platelet degranulation|regulation of proteolysis	extracellular space|platelet alpha granule lumen|proteinaceous extracellular matrix	protease binding|serine-type endopeptidase inhibitor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|skin(6)|stomach(1)	24		all_cancers(154;0.0649)|all_epithelial(191;0.223)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)	Alpha-1-proteinase inhibitor(DB00058)	CTCAGCCAGGGAGACAGGGAC	0.612000													7	75					0	0	1	0	0
ZC3HAV1L	92092	broad.mit.edu	37	7	138713609	138713609	+	Missense_Mutation	SNP	C	C	A			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr7:138713609C>A	ENST00000275766.1	-	3	610	c.599G>T	c.(598-600)gGa>gTa	p.G200V		NM_080660.3	NP_542391.2	Q96H79	ZCCHL_HUMAN	zinc finger CCCH-type, antiviral 1-like	200										NS(2)|endometrium(2)|large_intestine(1)|lung(4)|skin(1)	10						TTTGCATTCTCCTTTCACAAA	0.448000													9	31					0.000274275	0.000286427	1	1	0
GBF1	8729	broad.mit.edu	37	10	104135126	104135126	+	Missense_Mutation	SNP	C	C	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr10:104135126C>T	ENST00000369983.3	+	30	3928	c.3668C>T	c.(3667-3669)tCc>tTc	p.S1223F		NM_001199378.1|NM_001199379.1|NM_004193.2	NP_001186307.1|NP_001186308.1|NP_004184.1	Q92538	GBF1_HUMAN	golgi brefeldin A resistant guanine nucleotide exchange factor 1	1223					COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|regulation of ARF protein signal transduction|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(14)|kidney(8)|large_intestine(15)|lung(19)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	71		Colorectal(252;0.0236)		Epithelial(162;5.16e-08)|all cancers(201;1.19e-06)		GTGCTGCTCTCCCTGCGCATT	0.577000													11	67					0	0	1	0	0
CDC14A	8556	broad.mit.edu	37	1	100818542	100818542	+	Missense_Mutation	SNP	C	C	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr1:100818542C>T	ENST00000370125.2	+	1	520	c.32C>T	c.(31-33)gCt>gTt	p.A11V	CDC14A_ENST00000542213.1_Intron|CDC14A_ENST00000370124.3_Missense_Mutation_p.A11V|CDC14A_ENST00000336454.3_Missense_Mutation_p.A11V|CDC14A_ENST00000361544.6_Missense_Mutation_p.A11V|CDC14A_ENST00000544534.1_Missense_Mutation_p.A11V			Q9UNH5	CC14A_HUMAN	cell division cycle 14A	11	A.				cell cycle|cell division|cell proliferation	centrosome|nucleus|spindle	protein binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			breast(1)|endometrium(5)|kidney(6)|large_intestine(6)|lung(10)|skin(2)|urinary_tract(1)	31		all_epithelial(167;3.71e-06)|all_lung(203;0.00097)|Lung NSC(277;0.001)		Epithelial(280;0.0676)|all cancers(265;0.127)|COAD - Colon adenocarcinoma(174;0.201)|Lung(183;0.227)|Colorectal(144;0.241)		CTAATCGGGGCTTGTGAGTTC	0.622000													5	52					0	0	1	0	0
H3F3AP4	440926	broad.mit.edu	37	2	175585079	175585079	+	RNA	DEL	A	A	-			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr2:175585079delA	ENST00000442996.1	+	0	217																											TTTCATTCTCAAAAAAAAAAA	0.368											OREG0015078	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	4	---	---	---	---					
DMXL1	1657	broad.mit.edu	37	5	118525523	118525524	+	Frame_Shift_Ins	INS	-	-	G	rs17144964	byFrequency	TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr5:118525523_118525524insG	ENST00000311085.8	+	29	7336_7337	c.7256_7257insG	c.(7255-7257)ggtfs	p.G2419fs	DMXL1_ENST00000539542.1_Frame_Shift_Ins_p.G2419fs	NM_005509.4	NP_005500.4	Q9Y485	DMXL1_HUMAN	Dmx-like 1	2419										breast(3)|central_nervous_system(1)|endometrium(14)|kidney(4)|large_intestine(20)|liver(6)|lung(28)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)	86		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		GAGTCACTGGCGGTTAAAGAAA	0.421													7	112	---	---	---	---					
SVEP1	79987	broad.mit.edu	37	9	113168593	113168594	+	Frame_Shift_Ins	INS	-	-	T			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr9:113168593_113168594insT	ENST00000401783.2	-	38	9622_9623	c.9286_9287insA	c.(9286-9288)acafs	p.T3096fs	SVEP1_ENST00000297826.5_Frame_Shift_Ins_p.T1022fs|SVEP1_ENST00000374469.1_Frame_Shift_Ins_p.T3073fs	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	3096	Sushi 28.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						ACTGCCTTGTATGACATATCCA	0.485													29	218	---	---	---	---					
PHRF1	57661	broad.mit.edu	37	11	607585	607590	+	In_Frame_Del	DEL	GCATCA	GCATCA	-			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr11:607585_607590delGCATCA	ENST00000264555.5	+	14	2257_2262	c.2129_2134delGCATCA	c.(2128-2136)tgc>t	p.CIS710del	PHRF1_ENST00000413872.2_In_Frame_Del_p.CIS708del|PHRF1_ENST00000533464.1_In_Frame_Del_p.CIS706del|PHRF1_ENST00000416188.2_In_Frame_Del_p.CIS709del	NM_020901.2	NP_065952.2	Q9P1Y6	PHRF1_HUMAN	PHD and ring finger domains 1	710							RNA polymerase binding|zinc ion binding			breast(1)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(13)|urinary_tract(2)	28						CCCAGTGCCTGCATCAGCCGACTGAC	0.684													16	105	---	---	---	---					
MMP12	4321	broad.mit.edu	37	11	102738795	102738796	+	RNA	INS	-	-	T	rs33924686	by1000genomes	TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr11:102738795_102738796insT	ENST00000532855.1	-	0	725_726							P39900	MMP12_HUMAN	matrix metallopeptidase 12 (macrophage elastase)						positive regulation of epithelial cell proliferation involved in wound healing|proteolysis|wound healing, spreading of epidermal cells	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding	p.N211fs*20(2)		autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	26		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.014)	Acetohydroxamic Acid(DB00551)	AGGAACAAGTGGTGCCTAAGAA	0.416													7	5	---	---	---	---					
RP11-377D9.3	0	broad.mit.edu	37	12	13174142	13174144	+	RNA	DEL	AAC	AAC	-	rs59907395		TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr12:13174142_13174144delAAC	ENST00000543321.1	+	0	1025																											ctgtctcaaaaacaacaacaaca	0.552													5	9	---	---	---	---					
SLC26A10	65012	broad.mit.edu	37	12	58014154	58014154	+	Frame_Shift_Del	DEL	C	C	-			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr12:58014154delC	ENST00000379218.2	+	1	462	c.151delC	c.(151-153)ccfs	p.P52fs	SLC26A10_ENST00000320442.4_Frame_Shift_Del_p.P52fs			Q8NG04	S2610_HUMAN	solute carrier family 26, member 10	52						integral to membrane	antiporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(5)|large_intestine(4)|lung(7)	19	Melanoma(17;0.122)					GGCCTCCGTGCCCCCGGTGTT	0.562													7	825	---	---	---	---					
BRCA2	675	broad.mit.edu	37	13	32911001	32911002	+	Frame_Shift_Ins	INS	-	-	A			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr13:32911001_32911002insA	ENST00000544455.1	+	11	2736_2737	c.2509_2510insA	c.(2509-2511)aaafs	p.K837fs	BRCA2_ENST00000380152.3_Frame_Shift_Ins_p.K837fs	NM_000059.3	NP_000050.2	P51587	BRCA2_HUMAN	breast cancer 2, early onset	837	Interaction with NPM1.				cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			NS(3)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(32)|liver(1)|lung(41)|oesophagus(5)|ovary(22)|pancreas(4)|prostate(3)|salivary_gland(1)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	183		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		GTTGCCACCTGAAAAATACATG	0.307			"""D, Mis, N, F, S"""		"""breast, ovarian, pancreatic"""	"""breast, ovarian, pancreatic, leukemia  (FANCB, FANCD1)"""		Homologous recombination	Pancreatic Cancer, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Prostate Cancer;Hereditary Breast-Ovarian Cancer, BRCA2 type;Fanconi Anemia type D1, bi-allelic BRCA2 mutations;Fanconi Anemia	TCGA Ovarian(8;0.087)			7	59	---	---	---	---					
GALK1	2584	broad.mit.edu	37	17	73758797	73758797	+	Frame_Shift_Del	DEL	C	C	-			TCGA-MT-A67D-01A-31D-A30E-08	TCGA-MT-A67D-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1755566d-3b50-4ce5-b912-577022096fd5	7986c53f-94a9-4dad-bfac-359d75bad617	g.chr17:73758797delC	ENST00000588479.1	-	5	1355	c.781delG	c.(781-783)aafs	p.E262fs	GALK1_ENST00000437911.1_Frame_Shift_Del_p.E292fs|GALK1_ENST00000225614.2_Frame_Shift_Del_p.E262fs			P51570	GALK1_HUMAN	galactokinase 1	262					galactose catabolic process	cytosol	ATP binding|galactokinase activity|galactose binding			endometrium(2)|large_intestine(1)|lung(1)|prostate(1)	5	all_cancers(13;1.5e-07)		all cancers(21;1.03e-06)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			TCTAGCTCTTCCAGTTGTACC	0.667													14	77	---	---	---	---