Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SYCP2	10388	broad.mit.edu	37	20	58471566	58471566	+	Missense_Mutation	SNP	T	T	A			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr20:58471566T>A	ENST00000357552.3	-	19	1647	c.1422A>T	c.(1420-1422)aaA>aaT	p.K474N	SYCP2_ENST00000371001.2_Missense_Mutation_p.K474N			Q9BX26	SYCP2_HUMAN	synaptonemal complex protein 2	474					cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding	p.K474N(1)		NS(4)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(14)|lung(12)|ovary(4)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)			ACATTTTTCTTTTGCTAGGAG	0.318000													7	38					0	0	0.003080	0	0
CNOT1	23019	broad.mit.edu	37	16	58583721	58583721	+	Missense_Mutation	SNP	C	C	G			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr16:58583721C>G	ENST00000317147.5	-	25	3756	c.3424G>C	c.(3424-3426)Gag>Cag	p.E1142Q	CNOT1_ENST00000245138.4_Missense_Mutation_p.E32Q|CNOT1_ENST00000441024.2_Missense_Mutation_p.E1142Q|CNOT1_ENST00000569240.1_Missense_Mutation_p.E1137Q	NM_001265612.1|NM_016284.4	NP_001252541.1|NP_057368.3	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	1142					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				breast(1)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(24)|lung(25)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(2)	87				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		AAGTTTGGCTCAATACTGACT	0.393000													6	87					0	0	0.001984	0	0
GRM2	2912	broad.mit.edu	37	3	51743211	51743211	+	Missense_Mutation	SNP	G	G	A	rs144180122	by1000genomes	TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr3:51743211G>A	ENST00000395052.3	+	2	446	c.212G>A	c.(211-213)cGc>cAc	p.R71H	GRM2_ENST00000442933.2_Missense_Mutation_p.R71H|GRM2_ENST00000475478.1_Intron	NM_000839.3	NP_000830.2	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2	71					synaptic transmission	integral to plasma membrane				breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(1)|lung(11)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	GCACTGGACCGCATCAACCGT	0.632000													8	89					0	0	0.004482	0	0
SLC6A6	6533	broad.mit.edu	37	3	14526472	14526472	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr3:14526472C>T	ENST00000454876.2	+	15	2149	c.1820C>T	c.(1819-1821)gCt>gTt	p.A607V	SLC6A6_ENST00000360861.3_Missense_Mutation_p.A607V			P31641	SC6A6_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 6	607					cellular amino acid metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity|taurine:sodium symporter activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)|skin(2)	28						ATGAACGGCGCTCTCGTGAAA	0.577000													3	22					0	0	0.004672	0	0
KDM3B	51780	broad.mit.edu	37	5	137727180	137727180	+	Missense_Mutation	SNP	A	A	G			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr5:137727180A>G	ENST00000314358.5	+	8	2059	c.1859A>G	c.(1858-1860)aAt>aGt	p.N620S	KDM3B_ENST00000394866.1_Missense_Mutation_p.N276S|KDM3B_ENST00000542866.1_Intron	NM_016604.3	NP_057688.2	Q7LBC6	KDM3B_HUMAN	lysine (K)-specific demethylase 3B	620					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(15)|liver(2)|lung(18)|ovary(4)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	65						AATCATGAAAATCTATTTTTA	0.507000													13	104					0	0	0.001855	0	0
THAP2	83591	broad.mit.edu	37	12	72070612	72070612	+	Silent	SNP	G	G	A			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr12:72070612G>A	ENST00000308086.2	+	3	1912	c.411G>A	c.(409-411)agG>agA	p.R137R	RP11-293I14.2_ENST00000548802.1_Intron	NM_031435.3	NP_113623.1	Q9H0W7	THAP2_HUMAN	THAP domain containing, apoptosis associated protein 2	137						nucleolus	DNA binding|metal ion binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|skin(1)	10						CAAAAAAGAGGATCATTAAAC	0.383000													6	65					0	0	0.001168	0	0
SESN3	143686	broad.mit.edu	37	11	94911920	94911920	+	Missense_Mutation	SNP	T	T	G			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr11:94911920T>G	ENST00000536441.1	-	7	1346	c.1010A>C	c.(1009-1011)gAc>gCc	p.D337A	RP11-712B9.2_ENST00000534891.1_RNA|SESN3_ENST00000278499.2_Missense_Mutation_p.D198A|RP11-712B9.2_ENST00000534864.1_RNA	NM_001271594.1|NM_144665.2	NP_001258523.1|NP_653266.2	P58005	SESN3_HUMAN	sestrin 3	337					cell cycle arrest	nucleus				endometrium(5)|large_intestine(6)|lung(3)|skin(1)|stomach(1)	16		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)		BRCA - Breast invasive adenocarcinoma(274;0.234)		TCTGGCAAAGTCTTCATACCC	0.363000													7	46					0	0	0.001984	0	0
LDLRAD4	753	broad.mit.edu	37	18	13645527	13645527	+	Silent	SNP	C	C	T			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr18:13645527C>T	ENST00000361205.4	+	7	1460	c.792C>T	c.(790-792)ggC>ggT	p.G264G	LDLRAD4_ENST00000359446.5_Silent_p.G264G|LDLRAD4_ENST00000586765.1_Silent_p.G209G|LDLRAD4_ENST00000399848.3_Silent_p.G246G|RP11-701H16.4_ENST00000588397.1_RNA|LDLRAD4_ENST00000587757.1_Silent_p.G227G|LDLRAD4_ENST00000592991.1_Silent_p.G166G|LDLRAD4_ENST00000585931.1_Silent_p.G187G	NM_001276249.1|NM_181481.3	NP_001263178.1|NP_852146.1			low density lipoprotein receptor class A domain containing 4																		ACCACCCAGGCGCCTCTTTCC	0.597000													9	60					0	0	0.006214	0	0
LRBA	987	broad.mit.edu	37	4	151509256	151509256	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr4:151509256C>T	ENST00000535741.1	-	40	6747	c.6274G>A	c.(6274-6276)Gaa>Aaa	p.E2092K	LRBA_ENST00000507224.1_Missense_Mutation_p.E2092K|LRBA_ENST00000510413.1_Missense_Mutation_p.E2092K|LRBA_ENST00000357115.3_Missense_Mutation_p.E2103K			P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and anchor containing	2103						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(20)|lung(32)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	91	all_hematologic(180;0.151)					AAATAGAGTTCGGAGGAGGTG	0.463000													10	91					0	0	0.000673	0	0
PCDHGB3	56102	broad.mit.edu	37	5	140751490	140751490	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr5:140751490G>A	ENST00000576222.1	+	1	1660	c.1529G>A	c.(1528-1530)cGg>cAg	p.R510Q	PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron	NM_018924.2|NM_032097.1	NP_061747.1|NP_115268.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGAGCGCGCGGAGCGGGGTG	0.667000													10	50					0	0	0.006214	0	0
TOMM34	10953	broad.mit.edu	37	20	43585027	43585027	+	Splice_Site	SNP	G	G	A			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr20:43585027G>A	ENST00000372813.3	-	2	379	c.227_splice	c.e2+1	p.S76_splice	PABPC1L_ENST00000490798.1_Intron|PABPC1L_ENST00000372819.1_Intron	NM_006809.4	NP_006800.2	Q15785	TOM34_HUMAN	translocase of outer mitochondrial membrane 34	76					protein targeting to mitochondrion	integral to membrane|mitochondrial outer membrane	heat shock protein binding|signal sequence binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)	11		Myeloproliferative disorder(115;0.0122)				GGCCACTTACGAAGTGCAATC	0.468000													14	203					0	0	0.004990	0	0
DNAH8	1769	broad.mit.edu	37	6	38840791	38840791	+	Silent	SNP	C	C	T			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr6:38840791C>T	ENST00000359357.3	+	49	6950	c.6696C>T	c.(6694-6696)cgC>cgT	p.R2232R	DNAH8_ENST00000449981.2_Silent_p.R2449R|DNAH8_ENST00000441566.1_Silent_p.R2196R					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						ATGGAGATCGCATTCCCATGG	0.443000													12	82					0	0	0.001855	0	0
TTF2	8458	broad.mit.edu	37	1	117624536	117624536	+	Nonsense_Mutation	SNP	A	A	T			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr1:117624536A>T	ENST00000369466.3	+	10	1914	c.1870A>T	c.(1870-1872)Aaa>Taa	p.K624*		NM_003594.3	NP_003585.3	Q9UNY4	TTF2_HUMAN	transcription termination factor, RNA polymerase II	624	Helicase ATP-binding.				mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|termination of RNA polymerase II transcription	cytoplasm|spliceosomal complex|transcription elongation factor complex	ATP binding|ATP-dependent helicase activity|DNA binding|DNA-dependent ATPase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|liver(1)|lung(24)|ovary(1)|prostate(2)|skin(2)|urinary_tract(2)	50	Lung SC(450;0.225)	all_cancers(81;4.23e-06)|all_epithelial(167;3.65e-07)|all_lung(203;2.81e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0553)|Colorectal(144;0.179)|LUSC - Lung squamous cell carcinoma(189;0.19)		AGAAAAGGAGAAAAGCACAGC	0.453000													5	53					0	0	0.000602	0	0
CCDC180	100499483	broad.mit.edu	37	9	100127991	100127991	+	Missense_Mutation	SNP	G	G	T			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr9:100127991G>T	ENST00000375202.2	+	44	5501	c.4149G>T	c.(4147-4149)gaG>gaT	p.E1383D	CCDC180_ENST00000529487.1_Missense_Mutation_p.E1383D|RP11-23J9.4_ENST00000534123.1_RNA|CCDC180_ENST00000357054.1_Missense_Mutation_p.E1328D|CCDC180_ENST00000395220.1_3'UTR					coiled-coil domain containing 180																		TCCTCTGGGAGAGCAGTGAGA	0.562000													16	54					1.99824e-07	2.96797e-07	0.004990	1	0
ANKRD30BP2	149992	broad.mit.edu	37	21	14414844	14414844	+	RNA	SNP	T	T	C	rs148060711	by1000genomes	TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr21:14414844T>C	ENST00000507941.1	+	0	95																											ACTGGGCCTGTGCCAATGGCC	0.433000													7	40					0	0	0.006214	0	0
OR4C16	219428	broad.mit.edu	37	11	55339695	55339695	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr11:55339695G>A	ENST00000314634.3	+	1	92	c.92G>A	c.(91-93)cGt>cAt	p.R31H		NM_001004701.2	NP_001004701.2	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C, member 16 (gene/pseudogene)	31					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R31H(2)|p.R31L(1)		central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(28)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	41		all_epithelial(135;0.0748)				ATTTTTTTGCGTCTCTACTTG	0.368000													7	89					0	0	0.001984	0	0
EFTUD1	79631	broad.mit.edu	37	15	82444535	82444535	+	Nonsense_Mutation	SNP	G	G	A			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr15:82444535G>A	ENST00000268206.7	-	18	2428	c.2260C>T	c.(2260-2262)Cga>Tga	p.R754*	EFTUD1_ENST00000359445.3_Nonsense_Mutation_p.R703*	NM_024580.5	NP_078856.4	Q7Z2Z2	ETUD1_HUMAN	elongation factor Tu GTP binding domain containing 1	754					mature ribosome assembly		GTP binding|GTPase activity|ribosome binding|translation elongation factor activity			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(14)|ovary(1)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	32						GGCATGGCTCGAACACTGAGC	0.438000													7	75					0	0	0.003080	0	0
TCEB3B	51224	broad.mit.edu	37	18	44559510	44559510	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr18:44559510C>T	ENST00000332567.4	-	1	2478	c.2126G>A	c.(2125-2127)cGg>cAg	p.R709Q	KATNAL2_ENST00000356157.7_Intron|KATNAL2_ENST00000245121.5_Intron|KATNAL2_ENST00000592005.1_Intron	NM_016427.2	NP_057511.2	Q8IYF1	ELOA2_HUMAN	transcription elongation factor B polypeptide 3B (elongin A2)	709					regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			breast(1)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|lung(24)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						GGGGTTGGCCCGCTTCTCAGG	0.672000													5	62					0	0	0.000602	0	0
SCML1	6322	broad.mit.edu	37	X	17768243	17768243	+	Missense_Mutation	SNP	C	C	G			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chrX:17768243C>G	ENST00000380043.3	+	5	780	c.452C>G	c.(451-453)aCt>aGt	p.T151S	SCML1_ENST00000380041.3_Missense_Mutation_p.T178S|SCML1_ENST00000380045.3_Missense_Mutation_p.T57S|SCML1_ENST00000398080.1_Missense_Mutation_p.T57S	NM_006746.4	NP_006737.2	Q9UN30	SCML1_HUMAN	sex comb on midleg-like 1 (Drosophila)	178					anatomical structure morphogenesis	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(3)|endometrium(2)|kidney(2)|large_intestine(2)|ovary(1)	10	Hepatocellular(33;0.183)					CTCAGCCGCACTCCGAGTCCA	0.522000													16	71					0	0	0.003163	0	0
WDR74	54663	broad.mit.edu	37	11	62606655	62606655	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr11:62606655C>T	ENST00000525239.1	-	4	761	c.224G>A	c.(223-225)gGc>gAc	p.G75D	WDR74_ENST00000311713.7_Missense_Mutation_p.G75D|WDR74_ENST00000525752.1_Missense_Mutation_p.G18D|WDR74_ENST00000540620.1_5'UTR|WDR74_ENST00000529106.1_Missense_Mutation_p.G75D|WDR74_ENST00000278856.4_Missense_Mutation_p.G75D			Q6RFH5	WDR74_HUMAN	WD repeat domain 74	75						nucleolus				kidney(2)|large_intestine(1)|liver(1)|lung(3)|ovary(1)	8						CTGGAATATGCCATCCTCGGT	0.652000													4	46					0	0	0.000248	0	0
ZFHX3	463	broad.mit.edu	37	16	72828433	72828433	+	Silent	SNP	G	G	A			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr16:72828433G>A	ENST00000268489.5	-	9	8820	c.8148C>T	c.(8146-8148)tgC>tgT	p.C2716C	ZFHX3_ENST00000397992.5_Silent_p.C1802C	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	2716					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding	p.C2716>?(1)		NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				AGAGCGCTCTGCAAAAAGGGC	0.562000													17	65					0	0	0.004007	0	0
C10orf107	219621	broad.mit.edu	37	10	63450358	63450358	+	Silent	SNP	A	A	G			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr10:63450358A>G	ENST00000330194.2	+	4	572	c.267A>G	c.(265-267)gaA>gaG	p.E89E		NM_173554.2	NP_775825.1	Q8IVU9	CJ107_HUMAN	chromosome 10 open reading frame 107	89										breast(1)|kidney(1)|lung(4)|prostate(1)|skin(1)	8	Prostate(12;0.016)					CTGCCAGGGAAGAAATTGTGA	0.343000													7	46					0	0	0.003080	0	0
C22orf42	150297	broad.mit.edu	37	22	32548591	32548591	+	Silent	SNP	C	C	T			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr22:32548591C>T	ENST00000382097.3	-	3	402	c.330G>A	c.(328-330)gcG>gcA	p.A110A		NM_001010859.1	NP_001010859.1	Q6IC83	CV042_HUMAN	chromosome 22 open reading frame 42	110										NS(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(2)	24						CGTGTGCAGACGCCTGCACAT	0.493000													6	46					0	0	0.001984	0	0
ST8SIA1	6489	broad.mit.edu	37	12	22408274	22408274	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr12:22408274C>T	ENST00000396037.4	-	3	912	c.431G>A	c.(430-432)gGt>gAt	p.G144D	ST8SIA1_ENST00000539510.1_Intron	NM_003034.3	NP_003025.1	Q92185	SIA8A_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	144					glycosphingolipid biosynthetic process|protein glycosylation	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(10)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	25						CAGAATCCCACCATTTCCCAC	0.517000													10	100					0	0	0.001368	0	0
SMOC1	64093	broad.mit.edu	37	14	70444647	70444647	+	Missense_Mutation	SNP	A	A	G			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr14:70444647A>G	ENST00000381280.4	+	5	744	c.491A>G	c.(490-492)gAc>gGc	p.D164G	SMOC1_ENST00000361956.3_Missense_Mutation_p.D164G	NM_001034852.2|NM_022137.5	NP_001030024.1|NP_071420.1	Q9H4F8	SMOC1_HUMAN	SPARC related modular calcium binding 1	164					cell differentiation|eye development|limb development|regulation of osteoblast differentiation|signal transduction	basement membrane	calcium ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	21				all cancers(60;0.00417)|BRCA - Breast invasive adenocarcinoma(234;0.0119)|OV - Ovarian serous cystadenocarcinoma(108;0.028)		TCAGTCACCGACAAGCCCTTG	0.433000													6	56					0	0	0.001984	0	0
HTR1A	3350	broad.mit.edu	37	5	63256816	63256816	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr5:63256816G>A	ENST00000323865.3	-	1	964	c.731C>T	c.(730-732)gCa>gTa	p.A244V	RP11-158J3.2_ENST00000502882.1_RNA	NM_000524.3	NP_000515.2	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled	244				A -> AA (in Ref. 8).	behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(29)|ovary(2)|pancreas(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	56		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	GGCGGGAGATGCTCCATGGCG	0.632000													8	56					0	0	0.006214	0	0
LPHN1	22859	broad.mit.edu	37	19	14268749	14268749	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr19:14268749G>A	ENST00000340736.6	-	14	2792	c.2495C>T	c.(2494-2496)aCg>aTg	p.T832M	CTB-55O6.12_ENST00000588387.1_RNA|LPHN1_ENST00000361434.3_Missense_Mutation_p.T827M|CTB-55O6.12_ENST00000592086.1_RNA	NM_001008701.2	NP_001008701.1	O94910	LPHN1_HUMAN	latrophilin 1	832	GPS.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(3)|liver(1)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						GCAGGCACACGTGGTATGGGT	0.597000													5	61					0	0	0.000602	0	0
BAIAP3	8938	broad.mit.edu	37	16	1397985	1397985	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr16:1397985C>T	ENST00000324385.5	+	32	3379	c.3221C>T	c.(3220-3222)aCg>aTg	p.T1074M	BAIAP3_ENST00000568887.1_Missense_Mutation_p.T1011M|BAIAP3_ENST00000421665.2_Missense_Mutation_p.T1003M|BAIAP3_ENST00000397489.1_Missense_Mutation_p.T1056M|BAIAP3_ENST00000562208.1_Missense_Mutation_p.T1016M|BAIAP3_ENST00000397488.2_Missense_Mutation_p.T1056M|BAIAP3_ENST00000426824.3_Missense_Mutation_p.T1039M	NM_003933.4	NP_003924.2	O94812	BAIP3_HUMAN	BAI1-associated protein 3	1074	C2 2.				G-protein coupled receptor protein signaling pathway|neurotransmitter secretion		protein C-terminus binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(25)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42		Hepatocellular(780;0.0893)				AAGACCCGGACGCTGCACCCT	0.632000													11	74					0	0	0.000978	0	0
LEPREL4	10609	broad.mit.edu	37	17	39967445	39967445	+	Missense_Mutation	SNP	T	T	C			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr17:39967445T>C	ENST00000355468.3	-	3	1020	c.554A>G	c.(553-555)tAt>tGt	p.Y185C	LEPREL4_ENST00000393928.1_Missense_Mutation_p.Y185C			Q92791	SC65_HUMAN	leprecan-like 4	185					synaptonemal complex assembly	nucleolus|synaptonemal complex	binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|urinary_tract(1)	8						CATCCCCTGATAGTAGTTGAG	0.647000													27	233					0	0	0.001786	0	0
KIF3B	9371	broad.mit.edu	37	20	30897727	30897727	+	Silent	SNP	G	G	A			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr20:30897727G>A	ENST00000375712.3	+	2	314	c.147G>A	c.(145-147)acG>acA	p.T49T		NM_004798.3	NP_004789.1	O15066	KIF3B_HUMAN	kinesin family member 3B	49	Kinesin-motor.				anterograde axon cargo transport|blood coagulation|determination of left/right symmetry|mitotic centrosome separation|plus-end-directed vesicle transport along microtubule|spindle assembly involved in mitosis	centrosome|cytosol|kinesin II complex|plus-end kinesin complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|Rho GTPase binding			NS(2)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(5)|lung(9)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	36			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			CCAAAGGGACGGCCCATGAAA	0.512000													5	52					0	0	0.001168	0	0
VARS2	57176	broad.mit.edu	37	6	30888896	30888896	+	Nonsense_Mutation	SNP	C	C	T			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr6:30888896C>T	ENST00000321897.5	+	15	2166	c.1534C>T	c.(1534-1536)Cag>Tag	p.Q512*	VARS2_ENST00000416670.2_Nonsense_Mutation_p.Q512*|VARS2_ENST00000542001.1_Nonsense_Mutation_p.Q372*|VARS2_ENST00000476162.1_3'UTR|VARS2_ENST00000541562.1_Nonsense_Mutation_p.Q542*			Q5ST30	SYVM_HUMAN	valyl-tRNA synthetase 2, mitochondrial	512					valyl-tRNA aminoacylation	mitochondrion	ATP binding|valine-tRNA ligase activity			central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(15)|ovary(3)|prostate(3)|skin(4)|urinary_tract(1)	46						GAAGAACTGGCAGCACTGGTT	0.557000													6	45					0	0	0.001984	0	0
CCDC181	57821	broad.mit.edu	37	1	169390949	169390949	+	Silent	SNP	A	A	C			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr1:169390949A>C	ENST00000545005.1	-	4	1227	c.720T>G	c.(718-720)ccT>ccG	p.P240P	CCDC181_ENST00000367806.3_Silent_p.P240P|CCDC181_ENST00000367805.3_Silent_p.P240P|CCDC181_ENST00000491570.1_5'UTR					coiled-coil domain containing 181																		TATTAATGGGAGGCAAAAACC	0.408000													17	109					0	0	0.004007	0	0
FAM49B	51571	broad.mit.edu	37	8	130874554	130874554	+	Missense_Mutation	SNP	C	C	G			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr8:130874554C>G	ENST00000519824.2	-	5	495	c.222G>C	c.(220-222)aaG>aaC	p.K74N	FAM49B_ENST00000522250.1_5'UTR|FAM49B_ENST00000401979.2_Missense_Mutation_p.K74N|FAM49B_ENST00000519540.1_Missense_Mutation_p.K74N|FAM49B_ENST00000522941.1_Intron|FAM49B_ENST00000518879.1_5'UTR|FAM49B_ENST00000517654.1_Missense_Mutation_p.K74N|FAM49B_ENST00000522746.1_Missense_Mutation_p.K74N|FAM49B_ENST00000519110.1_Missense_Mutation_p.K74N|FAM49B_ENST00000523509.1_Missense_Mutation_p.K74N	NM_016623.4	NP_057707.3	Q9NUQ9	FA49B_HUMAN	family with sequence similarity 49, member B	74										kidney(1)|large_intestine(6)|lung(4)|prostate(1)	12	Ovarian(5;0.000567)|Esophageal squamous(12;0.00693)|Acute lymphoblastic leukemia(118;0.155)		LUAD - Lung adenocarcinoma(14;0.0989)			TCTCTTGCAACTTCTCATCTG	0.328000													8	87					0	0	0.006214	0	0
TRIM27	5987	broad.mit.edu	37	6	28871857	28871857	+	Missense_Mutation	SNP	G	G	C			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr6:28871857G>C	ENST00000377199.3	-	8	1888	c.1532C>G	c.(1531-1533)aCc>aGc	p.T511S	TRIM27_ENST00000377194.3_3'UTR	NM_006510.4	NP_006501.1	P14373	TRI27_HUMAN	tripartite motif containing 27	511					cell proliferation|negative regulation of gene expression, epigenetic|negative regulation of transcription from RNA polymerase II promoter|protein trimerization|spermatogenesis|transcription, DNA-dependent	cytoplasm|integral to plasma membrane|membrane fraction|nuclear membrane|PML body	DNA binding|protein binding|transmembrane receptor protein tyrosine kinase activity|zinc ion binding			endometrium(1)|large_intestine(2)|lung(6)|ovary(1)	10						TCAAGGGGAGGTCTCCATGGA	0.537000			T	RET	papillary thyroid								9	60					0	0	0.004482	0	0
SYT9	143425	broad.mit.edu	37	11	7439283	7439283	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr11:7439283G>A	ENST00000318881.6	+	5	1498	c.1261G>A	c.(1261-1263)Gaa>Aaa	p.E421K		NM_175733.3	NP_783860.1	Q86SS6	SYT9_HUMAN	synaptotagmin IX	421	C2 2.					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity	p.E421K(1)		NS(1)|endometrium(2)|large_intestine(9)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	38				Epithelial(150;1.34e-07)|LUSC - Lung squamous cell carcinoma(625;0.0949)		TGTTTACAACGAAGCCATAGT	0.468000													6	61					0	0	0.001984	0	0
UFL1	23376	broad.mit.edu	37	6	96971059	96971059	+	Silent	SNP	T	T	C			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr6:96971059T>C	ENST00000369278.4	+	2	181	c.115T>C	c.(115-117)Ttg>Ctg	p.L39L		NM_015323.4	NP_056138.1	O94874	UFL1_HUMAN	UFM1-specific ligase 1	39	Required for E3 UFM1-protein ligase activity.				negative regulation of NF-kappaB transcription factor activity|negative regulation of protein ubiquitination|protein ufmylation	endoplasmic reticulum|nucleus	protein binding|UFM1 conjugating enzyme activity										TGTTAATAAATTGATTGCTCA	0.368000													5	88					0	0	0.000602	0	0
CCT8L2	150160	broad.mit.edu	37	22	17072504	17072504	+	Missense_Mutation	SNP	C	C	G			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr22:17072504C>G	ENST00000359963.3	-	1	1196	c.937G>C	c.(937-939)Gtg>Ctg	p.V313L		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	313					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity	p.V313M(1)		breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				TGAATCACCACGATGCCATAC	0.557000													14	132					0	0	0.004007	0	0
SRGAP2	23380	broad.mit.edu	37	1	206628236	206628236	+	Silent	SNP	C	C	T			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr1:206628236C>T	ENST00000414007.1	+	17	1953	c.1953C>T	c.(1951-1953)gtC>gtT	p.V651V	SRGAP2_ENST00000471256.1_3'UTR|SRGAP2_ENST00000419187.2_Silent_p.V96V			O75044	FNBP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 2	791	Rho-GAP.				axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			NS(1)|breast(1)|kidney(1)|lung(1)	4	Breast(84;0.137)					AGGACGGTGTCGTGGAGAGGT	0.597000													4	34					0	0	0.000602	0	0
SLC38A9	153129	broad.mit.edu	37	5	54922346	54922346	+	Missense_Mutation	SNP	G	G	T			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr5:54922346G>T	ENST00000396865.2	-	16	2253	c.1662C>A	c.(1660-1662)aaC>aaA	p.N554K	SLC38A9_ENST00000416547.2_Missense_Mutation_p.N430K|SLC38A9_ENST00000539768.1_3'UTR|SLC38A9_ENST00000515629.1_Missense_Mutation_p.N491K|SLC38A9_ENST00000318672.3_Missense_Mutation_p.N554K|SLC38A9_ENST00000512595.1_Missense_Mutation_p.N491K	NM_173514.3	NP_775785.2	Q8NBW4	S38A9_HUMAN	solute carrier family 38, member 9	554					amino acid transport|sodium ion transport	integral to membrane				endometrium(1)|kidney(1)|large_intestine(3)|lung(3)	8		Lung NSC(810;0.00122)|Prostate(74;0.0376)|Breast(144;0.181)				GAACAATCAGGTTAGCCACGC	0.368000													12	86					0.000978159	0.00133505	0.000978	1	0
SLC44A4	80736	broad.mit.edu	37	6	31832499	31832499	+	Silent	SNP	C	C	A			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr6:31832499C>A	ENST00000544672.1	-	20	2009	c.1713G>T	c.(1711-1713)ggG>ggT	p.G571G	SLC44A4_ENST00000229729.6_Silent_p.G647G|SLC44A4_ENST00000375562.4_Silent_p.G605G	NM_001178045.1	NP_001171516.1	Q53GD3	CTL4_HUMAN	solute carrier family 44, member 4	647						integral to membrane|plasma membrane	choline transmembrane transporter activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|prostate(3)|skin(1)|urinary_tract(2)	35					Choline(DB00122)	TGACATAGGCCCCCAGGATGG	0.597000													7	79					8.12818e-05	0.000115626	0.001984	1	0
PCDH11X	27328	broad.mit.edu	37	X	91132437	91132437	+	Missense_Mutation	SNP	A	A	G			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chrX:91132437A>G	ENST00000373094.1	+	2	2043	c.1198A>G	c.(1198-1200)Aca>Gca	p.T400A	PCDH11X_ENST00000373097.1_Missense_Mutation_p.T400A|PCDH11X_ENST00000504220.1_Missense_Mutation_p.T400A|PCDH11X_ENST00000361655.2_Missense_Mutation_p.T400A|PCDH11X_ENST00000298274.8_Missense_Mutation_p.T400A|PCDH11X_ENST00000395337.2_Missense_Mutation_p.T400A|PCDH11X_ENST00000406881.1_Missense_Mutation_p.T400A|PCDH11X_ENST00000361724.1_Missense_Mutation_p.T400A|PCDH11X_ENST00000373088.1_Missense_Mutation_p.T400A	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	400	Cadherin 4.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						GACATGCTTCACAGATCATGA	0.418000													9	121					0	0	0.006214	0	0
DDX4	54514	broad.mit.edu	37	5	55110956	55110956	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr5:55110956C>T	ENST00000505374.1	+	20	2035	c.1943C>T	c.(1942-1944)tCg>tTg	p.S648L	DDX4_ENST00000511853.1_Missense_Mutation_p.S499L|DDX4_ENST00000353507.5_Missense_Mutation_p.S614L|DDX4_ENST00000354991.5_Missense_Mutation_p.S614L|DDX4_ENST00000514278.2_Missense_Mutation_p.S628L	NM_024415.2	NP_077726.1	Q9NQI0	DDX4_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 4	648	Helicase C-terminal.				multicellular organismal development|sperm motility	perinuclear region of cytoplasm|pi-body|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(8)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)	24		Lung NSC(810;6.93e-05)|all_neural(839;0.00409)|Prostate(74;0.0107)|Breast(144;0.0544)|Ovarian(174;0.223)				GATCTTGAATCGGATAACCAT	0.358000													6	104					0	0	0.001168	0	0
PRAMEF11	440560	broad.mit.edu	37	1	12887574	12887574	+	Missense_Mutation	SNP	C	C	G			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr1:12887574C>G	ENST00000535591.1	-	3	478	c.283G>C	c.(283-285)Gtg>Ctg	p.V95L		NM_001146344.1	NP_001139816.1	O60813	PRA11_HUMAN	PRAME family member 11	95										NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|lung(7)|pancreas(2)|skin(4)|urinary_tract(1)	27						CAGTCCTGCACTGGTGTTTTG	0.498000													11	236					0	0	0.002450	0	0
BRWD3	254065	broad.mit.edu	37	X	79932674	79932674	+	Missense_Mutation	SNP	A	A	G			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chrX:79932674A>G	ENST00000373275.4	-	41	5059	c.4843T>C	c.(4843-4845)Tct>Cct	p.S1615P		NM_153252.4	NP_694984.4	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	1615										breast(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(39)|ovary(4)|prostate(2)|skin(3)	87						GTACTTTCAGAACTTAAACTG	0.373000													5	136					0	0	0.000602	0	0
KMT2D	8085	broad.mit.edu	37	12	49445626	49445626	+	Nonsense_Mutation	SNP	C	C	A			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr12:49445626C>A	ENST00000301067.7	-	10	1839	c.1840G>T	c.(1840-1842)Gag>Tag	p.E614*		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		AGGGGAGACTCCTCAGGTGGA	0.602000													9	49					2.17888e-05	3.18937e-05	0.006214	1	0
FAM193B	54540	broad.mit.edu	37	5	176951739	176951739	+	Silent	SNP	G	G	A			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr5:176951739G>A	ENST00000329540.5	-	9	3450	c.621C>T	c.(619-621)aaC>aaT	p.N207N	FAM193B_ENST00000514747.1_Silent_p.N581N|FAM193B_ENST00000443375.2_Silent_p.N548N			Q6IPW0	Q6IPW0_HUMAN	family with sequence similarity 193, member B	257										kidney(1)|large_intestine(3)	4						TCACGAGCCCGTTCTCGGGGA	0.652000													4	8					0	0	0.000248	0	0
FLG	2312	broad.mit.edu	37	1	152280551	152280551	+	Missense_Mutation	SNP	C	C	A			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr1:152280551C>A	ENST00000368799.1	-	3	6846	c.6811G>T	c.(6811-6813)Gct>Tct	p.A2271S	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	2271	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGCTCCTGAGCAGATCCATGA	0.582000									Ichthyosis				25	264					5.45024e-15	8.21603e-15	0.003330	1	0
GPR112	139378	broad.mit.edu	37	X	135405364	135405364	+	Missense_Mutation	SNP	T	T	A			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chrX:135405364T>A	ENST00000394143.1	+	5	789	c.498T>A	c.(496-498)aaT>aaA	p.N166K	GPR112_ENST00000370652.1_Missense_Mutation_p.N166K|GPR112_ENST00000412101.1_Intron|GPR112_ENST00000394141.1_Intron|GPR112_ENST00000287534.4_Missense_Mutation_p.N103K	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	166					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					TTCTCAAGAATGAGAGCAGCG	0.448000													7	129					0	0	0.003080	0	0
PAX5	5079	broad.mit.edu	37	9	37015073	37015073	+	Missense_Mutation	SNP	C	C	A			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr9:37015073C>A	ENST00000358127.4	-	3	405	c.331G>T	c.(331-333)Gcc>Tcc	p.A111S	PAX5_ENST00000377847.2_Missense_Mutation_p.A111S|PAX5_ENST00000520154.1_Missense_Mutation_p.A111S|PAX5_ENST00000377853.2_Missense_Mutation_p.A111S|PAX5_ENST00000523241.1_Missense_Mutation_p.A111S|PAX5_ENST00000377852.2_Missense_Mutation_p.A111S|PAX5_ENST00000520281.1_Missense_Mutation_p.A111S|PAX5_ENST00000446742.1_Intron|PAX5_ENST00000414447.1_Missense_Mutation_p.A111S|PAX5_ENST00000522003.1_Missense_Mutation_p.A3S|PAX5_ENST00000523145.1_Missense_Mutation_p.A3S	NM_016734.1	NP_057953.1	Q02548	PAX5_HUMAN	paired box 5	111	Paired.				cell differentiation|humoral immune response|nervous system development|organ morphogenesis|spermatogenesis|transcription from RNA polymerase II promoter	nucleus	DNA binding	p.?(42)	PAX5/JAK2(18)	NS(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(151)|kidney(1)|lung(10)|prostate(1)|skin(1)	171		all_cancers(2;3.46e-10)|Acute lymphoblastic leukemia(2;7.09e-56)|all_hematologic(2;6.65e-44)		GBM - Glioblastoma multiforme(29;0.0108)		ATCTCCCAGGCAAACATGGTG	0.547000			"""T, Mis, D, F, S"""	"""IGH@, ETV6, PML, FOXP1, ZNF521, ELN"""	"""NHL, ALL, B-ALL"""								8	179					0.00448238	0.00603627	0.004482	1	0
FMN2	56776	broad.mit.edu	37	1	240371580	240371580	+	Silent	SNP	A	A	C			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr1:240371580A>C	ENST00000319653.9	+	5	3698	c.3468A>C	c.(3466-3468)ccA>ccC	p.P1156P		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	1156	FH1.|Pro-rich.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CTCCGCCCCCACTTCCCGGAG	0.706000													3	7					0	0	0.004672	0	0
HEY2	23493	broad.mit.edu	37	6	126080842	126080842	+	Missense_Mutation	SNP	T	T	G			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr6:126080842T>G	ENST00000368364.3	+	5	1105	c.908T>G	c.(907-909)aTc>aGc	p.I303S	HEY2_ENST00000368365.1_Missense_Mutation_p.I257S	NM_012259.2	NP_036391.1	Q9UBP5	HEY2_HUMAN	hes-related family bHLH transcription factor with YRPW motif 2	303					negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription initiation from RNA polymerase II promoter|negative regulation of transcription regulatory region DNA binding|Notch signaling pathway|smooth muscle cell differentiation|transcription, DNA-dependent	transcriptional repressor complex	histone deacetylase binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding			breast(1)|large_intestine(7)|lung(5)|prostate(1)	14				UCEC - Uterine corpus endometrioid carcinoma (4;0.0608)|GBM - Glioblastoma multiforme(226;0.0361)|all cancers(137;0.193)		GCCACAGCCATCAGCCCGCCC	0.622000													10	106					0	0	0.000673	0	0
PLK1	5347	broad.mit.edu	37	16	23695252	23695252	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr16:23695252G>A	ENST00000300093.4	+	5	989	c.878G>A	c.(877-879)cGc>cAc	p.R293H		NM_005030.3	NP_005021.2	P53350	PLK1_HUMAN	polo-like kinase 1	293	Protein kinase.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|G2/M transition DNA damage checkpoint|G2/M transition of mitotic cell cycle|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic prophase|negative regulation of cyclin-dependent protein kinase activity|peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein destabilization|protein localization to chromatin|protein ubiquitination|regulation of mitotic anaphase|regulation of protein binding	centrosome|condensed nuclear chromosome outer kinetochore|cytosol|nucleoplasm|spindle microtubule|spindle midzone|spindle pole	anaphase-promoting complex binding|ATP binding|polo kinase kinase activity|protein kinase binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23				GBM - Glioblastoma multiforme(48;0.0156)		CCCACTGCCCGCCCAACCATT	0.547000													12	250					0	0	0.001855	0	0
SLC28A1	9154	broad.mit.edu	37	15	85447424	85447424	+	Silent	SNP	C	C	T			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr15:85447424C>T	ENST00000394573.1	+	7	760	c.558C>T	c.(556-558)tgC>tgT	p.C186C	SLC28A1_ENST00000537216.1_Silent_p.C186C|SLC28A1_ENST00000286749.3_Silent_p.C186C|SLC28A1_ENST00000537624.1_Silent_p.C186C|SLC28A1_ENST00000537703.1_Silent_p.C108C|SLC28A1_ENST00000538177.1_Silent_p.C186C	NM_004213.3	NP_004204.3	O00337	S28A1_HUMAN	solute carrier family 28 (concentrative nucleoside transporter), member 1	186					nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)	41			BRCA - Breast invasive adenocarcinoma(143;0.0587)			CAGGAATCTGCGTGTTCGTCG	0.597000													5	87					0	0	0.001168	0	0
TAF6	6878	broad.mit.edu	37	7	99707619	99707619	+	Silent	SNP	C	C	T			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr7:99707619C>T	ENST00000344095.4	-	12	1761	c.1236G>A	c.(1234-1236)ctG>ctA	p.L412L	TAF6_ENST00000452041.1_Silent_p.L412L|TAF6_ENST00000472509.1_Silent_p.L469L|TAF6_ENST00000437822.2_Silent_p.L449L|TAF6_ENST00000418432.2_Silent_p.L336L|TAF6_ENST00000453269.2_Silent_p.L412L|AP4M1_ENST00000421755.1_Intron	NM_005641.3	NP_005632.1	P49848	TAF6_HUMAN	TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa	412					negative regulation of cell cycle|negative regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|liver(1)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|urinary_tract(2)	26	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CAATGTTGCTCAGCACAGGGC	0.582000													8	73					0	0	0.004482	0	0
SLC4A4	8671	broad.mit.edu	37	4	72412192	72412192	+	Silent	SNP	G	G	A			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr4:72412192G>A	ENST00000340595.3	+	16	2632	c.2436G>A	c.(2434-2436)aaG>aaA	p.K812K	SLC4A4_ENST00000264485.5_Silent_p.K856K|SLC4A4_ENST00000425175.1_Silent_p.K856K|SLC4A4_ENST00000351898.6_Intron	NM_003759.3	NP_003750.1	Q9Y6R1	S4A4_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 4	856						basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(1)|lung(21)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	58			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			ACAGTTTGAAGATGGAGACAG	0.483000													6	46					0	0	0.001168	0	0
KIF5A	3798	broad.mit.edu	37	12	57958726	57958726	+	Silent	SNP	C	C	T	rs143178113		TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr12:57958726C>T	ENST00000455537.2	+	6	745	c.471C>T	c.(469-471)caC>caT	p.H157H	KIF5A_ENST00000286452.5_Silent_p.H68H	NM_004984.2	NP_004975.2	Q12840	KIF5A_HUMAN	kinesin family member 5A	157	Kinesin-motor.				blood coagulation|cell death|microtubule-based movement|synaptic transmission	cytosol|kinesin complex|membrane fraction|microtubule|perinuclear region of cytoplasm	ATP binding|microtubule motor activity	p.H157H(1)		breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|liver(1)|lung(32)|ovary(2)|prostate(2)|skin(2)	62						TGTCCGTGCACGAGGACAAGA	0.532000													6	33					0	0	0.004482	0	0
PCSK1	5122	broad.mit.edu	37	5	95746485	95746485	+	Missense_Mutation	SNP	T	T	A			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr5:95746485T>A	ENST00000311106.3	-	8	1325	c.1088A>T	c.(1087-1089)cAg>cTg	p.Q363L	PCSK1_ENST00000513085.1_Intron|PCSK1_ENST00000508626.1_Missense_Mutation_p.Q316L|CTD-2337A12.1_ENST00000502645.2_RNA	NM_000439.4|NM_001177876.1	NP_000430.3|NP_001171347.1	P29120	NEC1_HUMAN	proprotein convertase subtilisin/kexin type 1	363	Catalytic.				cell-cell signaling|cellular nitrogen compound metabolic process|energy reserve metabolic process|hormone biosynthetic process|peptide biosynthetic process|peptide hormone processing|regulation of insulin secretion	extracellular space|stored secretory granule|transport vesicle	serine-type endopeptidase activity			NS(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(14)|ovary(2)|prostate(3)|skin(3)|urinary_tract(2)	36		all_cancers(142;2.67e-06)|all_epithelial(76;6.92e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0112)|Colorectal(57;0.0341)|Breast(839;0.244)		all cancers(79;3.44e-16)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TACGATTCTCTGGTCGGTGTA	0.512000													10	80					0	0	0.000673	0	0
ZNF540	163255	broad.mit.edu	37	19	38102814	38102814	+	Silent	SNP	T	T	C			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr19:38102814T>C	ENST00000592533.1	+	5	965	c.633T>C	c.(631-633)ggT>ggC	p.G211G	ZNF540_ENST00000316433.4_Silent_p.G211G|ZNF540_ENST00000589117.1_Silent_p.G179G|ZNF540_ENST00000343599.5_Silent_p.G211G	NM_152606.4	NP_689819.1			zinc finger protein 540											breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(13)|lung(8)|skin(1)	28			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TTCATACTGGTGAAAAATCCT	0.338000													3	50					0	0	0.000248	0	0
HIST1H2BM	8342	broad.mit.edu	37	6	27783137	27783137	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr6:27783137G>A	ENST00000359465.4	+	1	316	c.316G>A	c.(316-318)Gaa>Aaa	p.E106K		NM_003521.2	NP_003512.1	Q99879	H2B1M_HUMAN	histone cluster 1, H2bm	106					nucleosome assembly	nucleosome|nucleus	DNA binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(2)	12						GCTACCCGGGGAATTGGCCAA	0.622000													7	60					0	0	0.001984	0	0
SACS	26278	broad.mit.edu	37	13	23914846	23914846	+	Missense_Mutation	SNP	C	C	G			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr13:23914846C>G	ENST00000382298.3	-	10	3757	c.3169G>C	c.(3169-3171)Gat>Cat	p.D1057H	SACS_ENST00000402364.1_Missense_Mutation_p.D307H|SACS_ENST00000382292.3_Missense_Mutation_p.D1057H	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	1057					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		ACTTCTATATCAGGGTCAAAG	0.373000													5	115					0	0	0.000602	0	0
ANKRD36	375248	broad.mit.edu	37	2	97867947	97867947	+	Missense_Mutation	SNP	C	C	G	rs10203570	by1000genomes	TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr2:97867947C>G	ENST00000420699.2	+	47	3110	c.2866C>G	c.(2866-2868)Cag>Gag	p.Q956E	ANKRD36_ENST00000461153.2_Missense_Mutation_p.Q956E	NM_001164315.1	NP_001157787.1	A6QL64	AN36A_HUMAN	ankyrin repeat domain 36	956										endometrium(9)|kidney(5)|liver(1)|lung(3)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	23						AGTGTCTTCTCAGAAACCACC	0.343000													2	13					0	0	0.004672	0	0
FLNA	2316	broad.mit.edu	37	X	153594747	153594747	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chrX:153594747G>A	ENST00000422373.1	-	8	1405	c.1157C>T	c.(1156-1158)gCc>gTc	p.A386V	FLNA_ENST00000360319.4_Missense_Mutation_p.A386V|FLNA_ENST00000344736.4_Missense_Mutation_p.A386V|FLNA_ENST00000369850.3_Missense_Mutation_p.A386V	NM_001456.3	NP_001447.2	P21333	FLNA_HUMAN	filamin A, alpha	386					actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GGGACCTTGGGCTGTCACTTT	0.597000													7	58					0	0	0.004482	0	0
DNAH8	1769	broad.mit.edu	37	6	38816439	38816440	+	Frame_Shift_Ins	INS	-	-	A			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr6:38816439_38816440insA	ENST00000359357.3	+	35	4664_4665	c.4410_4411insA	c.(4408-4413)ttaaaafs	p.LK1470fs	DNAH8_ENST00000449981.2_Frame_Shift_Ins_p.LK1687fs|DNAH8_ENST00000441566.1_Frame_Shift_Ins_p.LK1470fs					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						ATGCTCCATTTAAAAAAAATAT	0.342													7	31	---	---	---	---					
AKAP9	10142	broad.mit.edu	37	7	91570433	91570435	+	In_Frame_Del	DEL	AGA	AGA	-			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr7:91570433_91570435delAGA	ENST00000359028.2	+	1	245_247	c.20_22delAGA	c.(19-24)cag>c	p.QK7del	AKAP9_ENST00000356239.3_In_Frame_Del_p.QK7del|AKAP9_ENST00000358100.2_In_Frame_Del_p.QK7del|AKAP9_ENST00000394564.1_In_Frame_Del_p.QK7del			Q99996	AKAP9_HUMAN	A kinase (PRKA) anchor protein 9	7					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			NS(1)|autonomic_ganglia(2)|breast(14)|central_nervous_system(3)|cervix(1)|endometrium(13)|kidney(12)|large_intestine(35)|lung(49)|ovary(8)|prostate(6)|skin(8)|stomach(1)|urinary_tract(2)	155	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			GAGGAGAGACAGAAGAAGCTGGA	0.635			T	BRAF	papillary thyroid								12	108	---	---	---	---					
ABCC3	8714	broad.mit.edu	37	17	48761081	48761082	+	Frame_Shift_Del	DEL	GA	GA	-			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr17:48761081_48761082delGA	ENST00000285238.8	+	27	3998_3999	c.3918_3919delGA	c.(3916-3921)ctgafs	p.LR1306fs		NM_003786.3	NP_003777.2	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	1306	ABC transporter 2.				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	ACCTGGTGCTGAGAGACCTGAG	0.644													15	77	---	---	---	---