Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
AKR1D1	6718	broad.mit.edu	37	7	137773485	137773485	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr7:137773485C>T	ENST00000242375.3	+	2	274	c.232C>T	c.(232-234)Cgg>Tgg	p.R78W	AKR1D1_ENST00000411726.2_Missense_Mutation_p.R78W|AKR1D1_ENST00000432161.1_Missense_Mutation_p.R78W|AKR1D1_ENST00000468877.2_Intron	NM_005989.3	NP_005980.1	P51857	AK1D1_HUMAN	aldo-keto reductase family 1, member D1	78					androgen metabolic process|bile acid biosynthetic process|bile acid catabolic process|C21-steroid hormone metabolic process|cholesterol catabolic process|digestion	cytosol	aldo-keto reductase (NADP) activity|delta4-3-oxosteroid 5beta-reductase activity|steroid binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(14)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	23						AGGAAAGGTGCGGAGGGAAGA	0.458000													6	11					0	0	1	0	0
APTX	54840	broad.mit.edu	37	9	32973634	32973634	+	Silent	SNP	T	T	A			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr9:32973634T>A	ENST00000379817.2	-	7	1087	c.891A>T	c.(889-891)gtA>gtT	p.V297V	APTX_ENST00000309615.3_3'UTR|APTX_ENST00000463596.1_Silent_p.V297V|APTX_ENST00000476858.1_Silent_p.V257V|APTX_ENST00000379825.2_3'UTR|APTX_ENST00000379813.3_Silent_p.V297V|APTX_ENST00000468275.1_Silent_p.V297V|APTX_ENST00000397172.3_Silent_p.V239V|APTX_ENST00000436040.2_3'UTR|APTX_ENST00000379819.1_Silent_p.V311V			Q7Z2E3	APTX_HUMAN	aprataxin	311					cell death|double-strand break repair|regulation of protein stability|response to hydrogen peroxide|single strand break repair	chromatin|nucleolus|nucleoplasm	chromatin binding|damaged DNA binding|DNA 5'-adenosine monophosphate hydrolase activity|double-stranded DNA binding|double-stranded RNA binding|phosphoglycolate phosphatase activity|phosphoprotein binding|polynucleotide 3'-phosphatase activity|protein N-terminus binding|zinc ion binding			endometrium(1)|lung(1)|ovary(2)|prostate(2)	6			LUSC - Lung squamous cell carcinoma(29;0.0302)	GBM - Glioblastoma multiforme(74;0.105)		CAGCCTCTTGTACCATCTCGA	0.453000								Editing and processing nucleases					31	16					0	0	1	0	0
ISL1	3670	broad.mit.edu	37	5	50689350	50689350	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr5:50689350C>T	ENST00000230658.7	+	6	1541	c.956C>T	c.(955-957)cCg>cTg	p.P319L	ISL1_ENST00000511384.1_Missense_Mutation_p.P296L	NM_002202.2	NP_002193.2	P61371	ISL1_HUMAN	ISL LIM homeobox 1	319	Gln-rich.				generation of precursor metabolites and energy|multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(11)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	31		Lung NSC(810;0.000845)|Breast(144;0.0411)				GAAGGAGGACCGGGCTCTAAT	0.393000													4	40					0	0	1	0	0
TAF13	6884	broad.mit.edu	37	1	109607266	109607266	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr1:109607266T>C	ENST00000338366.5	-	4	308	c.254A>G	c.(253-255)gAt>gGt	p.D85G		NM_005645.3	NP_005636.1	Q15543	TAF13_HUMAN	TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa	85					transcription elongation from RNA polymerase II promoter|viral reproduction	transcription factor TFIID complex	protein C-terminus binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(1)|lung(1)	3		all_epithelial(167;0.000102)|all_lung(203;0.000321)|Lung NSC(277;0.000626)		Colorectal(144;0.0138)|Lung(183;0.0425)|COAD - Colon adenocarcinoma(174;0.113)|Epithelial(280;0.166)|all cancers(265;0.191)|LUSC - Lung squamous cell carcinoma(189;0.228)		GAAGACGATATCTTCAACTTG	0.333000													68	101					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	228012208	228012208	+	Translation_Start_Site	SNP	A	A	T			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr2:228012208A>T	ENST00000396625.3	-	0	199				COL4A4_ENST00000329662.7_De_novo_Start_InFrame	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4						axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		ATCGCAGGCAAGTCTTAGTAC	0.453000													55	153					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100678325	100678325	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr7:100678325C>T	ENST00000306151.4	+	3	3692	c.3628C>T	c.(3628-3630)Cca>Tca	p.P1210S		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	1210	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity	p.P1210S(1)		NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					TACCAGCATGCCAACCTCAAC	0.512000													6	677					0	0	1	0	0
DUS3L	56931	broad.mit.edu	37	19	5786534	5786534	+	Silent	SNP	T	T	G			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr19:5786534T>G	ENST00000309061.7	-	10	1602	c.1506A>C	c.(1504-1506)tcA>tcC	p.S502S	DUS3L_ENST00000320699.8_Silent_p.S260S	NM_020175.2	NP_064560.2	Q96G46	DUS3L_HUMAN	dihydrouridine synthase 3-like (S. cerevisiae)	502					tRNA processing		flavin adenine dinucleotide binding|nucleic acid binding|tRNA dihydrouridine synthase activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|prostate(1)|skin(2)	14						CATCCTCAAATGACAAGATGT	0.572000													11	4					0	0	1	0	0
ZNF10	7556	broad.mit.edu	37	12	133727720	133727720	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr12:133727720A>G	ENST00000248211.6	+	3	362	c.140A>G	c.(139-141)tAt>tGt	p.Y47C	ZNF268_ENST00000416488.1_Missense_Mutation_p.Y47C|ZNF10_ENST00000540927.1_3'UTR|CTD-2140B24.4_ENST00000540096.2_Missense_Mutation_p.Y47C|ZNF10_ENST00000426665.2_Missense_Mutation_p.Y47C|ZNF10_ENST00000402932.2_Missense_Mutation_p.Y47C	NM_015394.4	NP_056209.2	P21506	ZNF10_HUMAN	zinc finger protein 10	47	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(9)|prostate(1)|skin(5)|urinary_tract(1)	26	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;1.28e-06)|all_epithelial(31;0.0051)|Lung NSC(355;0.00948)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		CTGGAGAACTATAAGAACCTG	0.453000													33	43					0	0	1	0	0
FAM21C	253725	broad.mit.edu	37	10	46250556	46250556	+	Silent	SNP	T	T	C			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr10:46250556T>C	ENST00000336378.4	+	15	1531	c.1413T>C	c.(1411-1413)tcT>tcC	p.S471S	FAM21C_ENST00000537517.1_Silent_p.S447S|FAM21C_ENST00000540872.1_Silent_p.S471S|FAM21C_ENST00000359860.4_Silent_p.S415S|FAM21C_ENST00000374362.2_Silent_p.S471S	NM_015262.2	NP_056077.2	A8K5W5	A8K5W5_HUMAN	family with sequence similarity 21, member C	471										central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	28						GCAAACCTTCTAAAACACGTA	0.458000													4	4					0	0	1	0	0
ZNF180	7733	broad.mit.edu	37	19	44981361	44981361	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr19:44981361A>T	ENST00000221327.4	-	5	1618	c.1337T>A	c.(1336-1338)tTc>tAc	p.F446Y	ZNF180_ENST00000391956.4_Missense_Mutation_p.F421Y|ZNF180_ENST00000592529.1_Missense_Mutation_p.F419Y	NM_013256.3	NP_037388.2	Q9UJW8	ZN180_HUMAN	zinc finger protein 180	446					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(3)|kidney(5)|large_intestine(14)|lung(6)|ovary(2)|urinary_tract(1)	33		Prostate(69;0.0435)				GCTCTGCCTGAATGACTTTCC	0.393000													24	30					0	0	1	0	0
COPG1	22820	broad.mit.edu	37	3	128976661	128976661	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr3:128976661C>G	ENST00000314797.6	+	10	933	c.829C>G	c.(829-831)Ctg>Gtg	p.L277V		NM_016128.3	NP_057212.1	Q9Y678	COPG_HUMAN	coatomer protein complex, subunit gamma 1	277					COPI coating of Golgi vesicle|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity										CATCGTCAATCTGCCAGGCTG	0.567000													8	233					0	0	1	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													3	41					0	0	1	0	0
COL18A1	80781	broad.mit.edu	37	21	46888461	46888461	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr21:46888461C>T	ENST00000359759.4	+	2	1678	c.1657C>T	c.(1657-1659)Ctc>Ttc	p.L553F	COL18A1_ENST00000355480.5_Missense_Mutation_p.L318F|COL18A1_ENST00000400337.2_Missense_Mutation_p.L138F			P39060	COIA1_HUMAN	collagen, type XVIII, alpha 1	553	TSP N-terminal.				cell adhesion|negative regulation of cell proliferation|organ morphogenesis|visual perception	collagen|extracellular space	extracellular matrix structural constituent|metal ion binding|protein binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	25				Colorectal(79;0.0157)|READ - Rectum adenocarcinoma(84;0.0929)		CATCTCCCTGCTCTACACAGA	0.662000													49	82					0	0	1	0	0
FRG1BP	284802	broad.mit.edu	37	20	29625941	29625941	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr20:29625941A>T	ENST00000278882.3	+	5	565	c.185A>T	c.(184-186)gAt>gTt	p.D62V	FRG1B_ENST00000358464.4_Missense_Mutation_p.D62V|FRG1B_ENST00000439954.2_Missense_Mutation_p.D67V														p.D62V(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GGGCATTCAGATGCAATTGGA	0.333000													4	102					0	0	1	0	0
OR2AG2	338755	broad.mit.edu	37	11	6789864	6789864	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr11:6789864T>C	ENST00000338569.2	-	1	422	c.325A>G	c.(325-327)Agc>Ggc	p.S109G		NM_001004490.1	NP_001004490.1	A6NM03	O2AG2_HUMAN	olfactory receptor, family 2, subfamily AG, member 2	109					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(13)|ovary(1)|skin(5)|stomach(1)|urinary_tract(1)	28		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)		Epithelial(150;2.15e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		TCCTCAGCGCTACCCATTGTC	0.522000													21	45					0	0	1	0	0
STARD5	80765	broad.mit.edu	37	15	81614837	81614837	+	Nonsense_Mutation	SNP	C	C	T			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr15:81614837C>T	ENST00000302824.6	-	3	219	c.194G>A	c.(193-195)tGg>tAg	p.W65*	STARD5_ENST00000559913.1_5'UTR	NM_181900.2	NP_871629.1	Q9NSY2	STAR5_HUMAN	StAR-related lipid transfer (START) domain containing 5	65	START.				C21-steroid hormone biosynthetic process|lipid transport	cytosol	lipid binding			large_intestine(3)|ovary(1)|skin(1)|stomach(1)	6						CACACAGTCCCACACCTCCTC	0.473000													7	78					0	0	1	0	0
ARHGAP29	9411	broad.mit.edu	37	1	94640173	94640173	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr1:94640173G>A	ENST00000260526.6	-	23	3220	c.3038C>T	c.(3037-3039)aCc>aTc	p.T1013I		NM_004815.3	NP_004806.3	Q52LW3	RHG29_HUMAN	Rho GTPase activating protein 29	1013					Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			NS(1)|breast(5)|endometrium(6)|kidney(2)|large_intestine(9)|lung(19)|ovary(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		TCTAATCTTGGTCCTTGGAGT	0.398000													47	75					0	0	1	0	0
DCLK1	9201	broad.mit.edu	37	13	36700177	36700177	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr13:36700177G>A	ENST00000255448.4	-	2	309	c.98C>T	c.(97-99)cCg>cTg	p.P33L	DCLK1_ENST00000379892.4_Missense_Mutation_p.P33L|DCLK1_ENST00000360631.3_Missense_Mutation_p.P33L	NM_004734.4	NP_004725.1	O15075	DCLK1_HUMAN	doublecortin-like kinase 1	33					cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(18)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(6)|urinary_tract(1)	64		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		GCTGTGCGTCGGGCTCGGCAG	0.607000													60	30					0	0	1	0	0
SCNN1G	6340	broad.mit.edu	37	16	23226426	23226426	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr16:23226426C>A	ENST00000300061.2	+	13	1729	c.1586C>A	c.(1585-1587)tCc>tAc	p.S529Y		NM_001039.3	NP_001030.2	P51170	SCNNG_HUMAN	sodium channel, non-voltage-gated 1, gamma subunit	529					excretion|sensory perception of taste	apical plasma membrane|integral to plasma membrane	ligand-gated sodium channel activity|WW domain binding			NS(2)|autonomic_ganglia(1)|breast(1)|cervix(2)|kidney(1)|large_intestine(9)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	34				GBM - Glioblastoma multiforme(48;0.0366)	Amiloride(DB00594)|Triamterene(DB00384)	ATGCTTCTGTCCAACTTCGGT	0.542000													20	28					2.4624e-09	2.74752e-09	1	1	0
SLC5A12	159963	broad.mit.edu	37	11	26714150	26714150	+	Splice_Site	SNP	T	T	C			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr11:26714150T>C	ENST00000396005.3	-	9	1350		c.e9-2		SLC5A12_ENST00000280467.6_Splice_Site	NM_178498.3	NP_848593.2	Q1EHB4	SC5AC_HUMAN	solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12						sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(16)|ovary(2)|prostate(1)|skin(2)|stomach(1)	35						GCCACGGTGCTATAAGGAAAG	0.488000													4	56					0	0	1	0	0
CYP4A22	284541	broad.mit.edu	37	1	47611577	47611577	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr1:47611577A>G	ENST00000371891.3	+	10	1293	c.1262A>G	c.(1261-1263)aAc>aGc	p.N421S	CYP4A22_ENST00000294337.3_Missense_Mutation_p.N421S|CYP4A22_ENST00000371890.3_Missense_Mutation_p.N323S|CYP4A22_ENST00000485117.1_3'UTR|CYP4A22-AS1_ENST00000444042.2_lincRNA	NM_001010969.2	NP_001010969.2	Q5TCH4	CP4AM_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 22	421						endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						CTTCACCACAACCCAAAAGTG	0.517000													150	230					0	0	1	0	0
NAA25	80018	broad.mit.edu	37	12	112481439	112481439	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr12:112481439T>C	ENST00000261745.4	-	18	2488	c.2240A>G	c.(2239-2241)aAg>aGg	p.K747R		NM_024953.3	NP_079229.2	Q14CX7	NAA25_HUMAN	N(alpha)-acetyltransferase 25, NatB auxiliary subunit	747						cytoplasm	protein binding			autonomic_ganglia(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(1)|lung(14)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(4)	46						CTGAATATCCTTCTCAATAAA	0.408000													28	46					0	0	1	0	0
TM9SF3	56889	broad.mit.edu	37	10	98307666	98307666	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr10:98307666T>C	ENST00000371142.4	-	8	1256	c.1040A>G	c.(1039-1041)tAt>tGt	p.Y347C	TM9SF3_ENST00000490192.1_5'UTR	NM_020123.3	NP_064508.3	Q9HD45	TM9S3_HUMAN	transmembrane 9 superfamily member 3	347						integral to membrane	binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(6)|lung(2)|prostate(1)	15		Colorectal(252;0.158)		Epithelial(162;1.84e-09)|all cancers(201;2.84e-08)		TTGTCTAGCATACAGACTTCC	0.353000													32	61					0	0	1	0	0
KCTD20	222658	broad.mit.edu	37	6	36454762	36454762	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr6:36454762A>G	ENST00000373731.2	+	8	1461	c.1070A>G	c.(1069-1071)aAg>aGg	p.K357R	KCTD20_ENST00000536244.1_Missense_Mutation_p.K212R|KCTD20_ENST00000449081.2_Missense_Mutation_p.K191R|KCTD20_ENST00000544295.1_Missense_Mutation_p.K111R|KCTD20_ENST00000474988.1_3'UTR	NM_173562.3	NP_775833.2	Q7Z5Y7	KCD20_HUMAN	potassium channel tetramerization domain containing 20	357						voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|skin(1)	15						TCATGGGAAAAGGAAGAAGGG	0.478000													4	152					0	0	1	0	0
PAPPA	5069	broad.mit.edu	37	9	118974096	118974096	+	Missense_Mutation	SNP	T	T	G			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr9:118974096T>G	ENST00000328252.3	+	4	2172	c.1803T>G	c.(1801-1803)aaT>aaG	p.N601K	PAPPA_ENST00000534838.1_Intron	NM_002581.3	NP_002572.2	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A, pappalysin 1	601					cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(9)|kidney(2)|large_intestine(23)|lung(33)|ovary(4)|pancreas(2)|prostate(5)|skin(7)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	98						ACCTCTGCAATGATACCAACC	0.532000													6	341					0	0	1	0	0
ZNF814	730051	broad.mit.edu	37	19	58385140	58385140	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr19:58385140G>T	ENST00000435989.2	-	3	1852	c.1618C>A	c.(1618-1620)Caa>Aaa	p.Q540K	ZNF814_ENST00000600634.1_Intron|ZNF814_ENST00000597832.1_Intron|ZNF814_ENST00000597342.1_Intron|ZNF814_ENST00000596604.1_Intron|ZNF814_ENST00000595295.1_Intron	NM_001144989.1	NP_001138461.1	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	540					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			NS(1)|central_nervous_system(2)|endometrium(3)|kidney(9)|lung(2)|prostate(4)|skin(1)|urinary_tract(3)	25						GTGTGAATTTGCTGATGGTTC	0.448000													3	40					0.115264	0.115264	1	1	0
ATP10D	57205	broad.mit.edu	37	4	47525029	47525029	+	Splice_Site	SNP	G	G	T			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr4:47525029G>T	ENST00000273859.3	+	4	755	c.485_splice	c.e4-1	p.R162_splice	ATP10D_ENST00000504445.1_Splice_Site_p.R162_splice	NM_020453.3	NP_065186.3	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	162					ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|endometrium(5)|kidney(5)|large_intestine(14)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(5)|skin(2)|stomach(1)|urinary_tract(1)	66						ttaattaCAGGAAAGAGAAAA	0.303000													8	27					0.00448238	0.00456858	1	1	0
NOC3L	64318	broad.mit.edu	37	10	96106181	96106181	+	Splice_Site	SNP	C	C	A			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr10:96106181C>A	ENST00000371361.3	-	11	1490		c.e11+1		NOC3L_ENST00000543788.1_Splice_Site|NOC3L_ENST00000371350.1_Splice_Site	NM_022451.9	NP_071896.8	Q8WTT2	NOC3L_HUMAN	nucleolar complex associated 3 homolog (S. cerevisiae)							nuclear speck|nucleolus	binding			endometrium(3)|large_intestine(17)|lung(5)|ovary(1)|skin(2)|stomach(1)	29		Colorectal(252;0.0897)				ATAAGTCAAACCTTTCTCTGC	0.259000													7	21					0.00198382	0.0020416	1	1	0
COL8A2	1296	broad.mit.edu	37	1	36564394	36564394	+	Silent	SNP	C	C	T			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr1:36564394C>T	ENST00000397799.1	-	4	1112	c.888G>A	c.(886-888)ggG>ggA	p.G296G	COL8A2_ENST00000481785.1_Silent_p.G231G|COL8A2_ENST00000303143.4_Silent_p.G296G			P25067	CO8A2_HUMAN	collagen, type VIII, alpha 2	296	Triple-helical region.				angiogenesis|cell-cell adhesion|extracellular matrix organization	basement membrane|collagen	extracellular matrix structural constituent|protein binding, bridging			NS(2)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(1)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	17		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CCCCTTTGGCCCCTGATGGGC	0.706000													16	40					0	0	1	0	0
TTC3	7267	broad.mit.edu	37	21	38560808	38560808	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr21:38560808G>C	ENST00000399017.2	+	39	7683	c.4936G>C	c.(4936-4938)Gaa>Caa	p.E1646Q	TTC3-AS1_ENST00000424733.1_RNA|TTC3_ENST00000479930.1_3'UTR|TTC3_ENST00000355666.1_Missense_Mutation_p.E1646Q|TTC3_ENST00000354749.2_Missense_Mutation_p.E1646Q	NM_003316.3	NP_003307.3	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	1646					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(5)|endometrium(7)|kidney(5)|large_intestine(17)|liver(1)|lung(18)|ovary(4)|prostate(2)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(5)	75		Myeloproliferative disorder(46;0.0412)				ATCCGTACTTGAAAACTGGAA	0.393000													15	30					0	0	1	0	0
BTBD8	284697	broad.mit.edu	37	1	92604962	92604962	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr1:92604962G>T	ENST00000370382.3	+	6	1075	c.808G>T	c.(808-810)Gac>Tac	p.D270Y	BTBD8_ENST00000342818.3_Missense_Mutation_p.D270Y|BTBD8_ENST00000540648.1_Missense_Mutation_p.D270Y			Q5XKL5	BTBD8_HUMAN	BTB (POZ) domain containing 8	270	BTB 2.					nucleus				breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(8)|ovary(1)	16		all_lung(203;0.0484)|Lung NSC(277;0.126)|Glioma(108;0.222)		all cancers(265;0.0153)|Epithelial(280;0.0982)		AGGAACTCTGGACATTCCAGA	0.303000													21	44					1.87028e-06	2.04381e-06	1	1	0
PDE7B	27115	broad.mit.edu	37	6	136476804	136476804	+	Silent	SNP	C	C	T			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr6:136476804C>T	ENST00000308191.6	+	8	922	c.619C>T	c.(619-621)Ctg>Ttg	p.L207L	RP13-143G15.4_ENST00000591521.1_RNA|RP13-143G15.4_ENST00000585946.1_RNA|RP13-143G15.4_ENST00000417643.1_RNA	NM_018945.3	NP_061818.1	Q9NP56	PDE7B_HUMAN	phosphodiesterase 7B	207	Catalytic (By similarity).				signal transduction|synaptic transmission	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(1)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	21	Colorectal(23;0.24)			OV - Ovarian serous cystadenocarcinoma(155;0.0136)|GBM - Glioblastoma multiforme(68;0.0147)	Dyphylline(DB00651)|Ketotifen(DB00920)	CATGCTTGGACTGCTGGCTGC	0.448000													23	28					0	0	1	0	0
CHEK2P2	646096	broad.mit.edu	37	15	20496736	20496736	+	RNA	SNP	C	C	G			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr15:20496736C>G	ENST00000555186.1	+	0	789					NR_038836.1																						ACTCTGTCATCTTTCTTTTCT	0.393000													6	24					0	0	1	0	0
KIF26A	26153	broad.mit.edu	37	14	104641958	104641958	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr14:104641958A>T	ENST00000315264.7	+	11	2794	c.2416A>T	c.(2416-2418)Agg>Tgg	p.R806W	KIF26A_ENST00000423312.2_Missense_Mutation_p.R945W			Q9ULI4	KI26A_HUMAN	kinesin family member 26A	945					blood coagulation|enteric nervous system development|microtubule-based movement|negative regulation of signal transduction|regulation of cell growth by extracellular stimulus	cytosol|microtubule	ATP binding|microtubule binding|microtubule motor activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	21		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0767)	Epithelial(46;0.152)	Epithelial(152;0.161)		GAGTGGAGGCAGGAGGCCACT	0.667000													10	14					0	0	1	0	0
MAP1B	4131	broad.mit.edu	37	5	71482572	71482572	+	Silent	SNP	C	C	T	rs111766097	byFrequency	TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr5:71482572C>T	ENST00000296755.7	+	4	799	c.501C>T	c.(499-501)acC>acT	p.T167T		NM_005909.3	NP_005900.2	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	167						microtubule|microtubule associated complex	structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(42)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	104		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		AGATTTTCACCGATCAAGAGG	0.493000													42	17					0	0	1	0	0
ZC3H15	55854	broad.mit.edu	37	2	187359982	187359982	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr2:187359982A>G	ENST00000337859.6	+	2	325	c.98A>G	c.(97-99)aAt>aGt	p.N33S	ZC3H15_ENST00000544130.1_5'UTR|ZC3H15_ENST00000468120.1_3'UTR	NM_018471.2	NP_060941.2	Q8WU90	ZC3HF_HUMAN	zinc finger CCCH-type containing 15	33						cytoplasm|nucleolus|plasma membrane	nucleic acid binding|zinc ion binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(4)|lung(5)|skin(1)	15			OV - Ovarian serous cystadenocarcinoma(117;0.0148)|Epithelial(96;0.0922)|all cancers(119;0.233)			GGTTTGAAGAATAAGAAAGGA	0.323000													12	18					0	0	1	0	0
ABL2	27	broad.mit.edu	37	1	179077872	179077872	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr1:179077872T>A	ENST00000502732.1	-	12	2733	c.2530A>T	c.(2530-2532)Agc>Tgc	p.S844C	ABL2_ENST00000504405.1_Missense_Mutation_p.S705C|ABL2_ENST00000408940.3_Missense_Mutation_p.S808C|ABL2_ENST00000512653.1_Missense_Mutation_p.S829C|ABL2_ENST00000367623.4_Missense_Mutation_p.S823C|ABL2_ENST00000344730.3_Missense_Mutation_p.S726C|ABL2_ENST00000511413.1_Missense_Mutation_p.S741C|ABL2_ENST00000507173.1_Missense_Mutation_p.S720C	NM_001168236.1|NM_001168237.1|NM_001168238.1|NM_007314.3	NP_001161708.1|NP_001161709.1|NP_001161710.1|NP_009298.1	P42684	ABL2_HUMAN	c-abl oncogene 2, non-receptor tyrosine kinase	844	F-actin-binding (By similarity).|Pro-rich.				axon guidance|cell adhesion|peptidyl-tyrosine phosphorylation|positive regulation of oxidoreductase activity|signal transduction	cytoskeleton|cytosol	ATP binding|magnesium ion binding|manganese ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(8)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	65					Adenosine triphosphate(DB00171)|Dasatinib(DB01254)	CTCTCCCTGCTTGGAGCAGCA	0.522000			T	ETV6	AML								53	57					0	0	1	0	0
OR2AG2	338755	broad.mit.edu	37	11	6789862	6789862	+	Silent	SNP	G	G	A	rs145583606	by1000genomes	TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr11:6789862G>A	ENST00000338569.2	-	1	424	c.327C>T	c.(325-327)agC>agT	p.S109S		NM_001004490.1	NP_001004490.1	A6NM03	O2AG2_HUMAN	olfactory receptor, family 2, subfamily AG, member 2	109					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.S109S(1)		breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(13)|ovary(1)|skin(5)|stomach(1)|urinary_tract(1)	28		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)		Epithelial(150;2.15e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		GGTCCTCAGCGCTACCCATTG	0.522000													18	43					0	0	1	0	0
LOC645752	645752	broad.mit.edu	37	15	78211548	78211548	+	RNA	SNP	T	T	C			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr15:78211548T>C	ENST00000565869.1	+	0	111				RP11-114H24.2_ENST00000567226.1_RNA																							CCACCTGGGATTGGAGCTTTC	0.562000													4	125					0	0	1	0	0
MTRR	4552	broad.mit.edu	37	5	7892899	7892899	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr5:7892899C>G	ENST00000264668.2	+	11	1541	c.1511C>G	c.(1510-1512)tCt>tGt	p.S504C	MTRR_ENST00000440940.2_Missense_Mutation_p.S477C	NM_002454.2|NM_024010.2	NP_002445.2|NP_076915.2	Q9UBK8	MTRR_HUMAN	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	504	FAD-binding FR-type.				methionine biosynthetic process	cytosol	[methionine synthase] reductase activity|flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding	p.S504F(1)		NS(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(14)|ovary(1)|prostate(3)|stomach(1)	31					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)|L-Methionine(DB00134)	GAATTTCTGTCTACTGCCACA	0.438000													5	132					0	0	1	0	0
ADAM21P1	145241	broad.mit.edu	37	14	70713010	70713010	+	RNA	SNP	T	T	C	rs148589381	by1000genomes	TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr14:70713010T>C	ENST00000530196.1	-	0	1508					NR_003951.1																						ATGGCATGAATTTGCAGTCTT	0.478000													8	48					0	0	1	0	0
DHX36	170506	broad.mit.edu	37	3	154022739	154022739	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr3:154022739T>A	ENST00000496811.1	-	8	1071	c.991A>T	c.(991-993)Atc>Ttc	p.I331F	DHX36_ENST00000308361.6_Missense_Mutation_p.I331F|DHX36_ENST00000329463.5_Missense_Mutation_p.I331F|DHX36_ENST00000544526.1_Missense_Mutation_p.I331F	NM_020865.2	NP_065916.2	Q9H2U1	DHX36_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 36	331	Helicase ATP-binding.					cytoplasm|nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(7)|lung(11)|prostate(2)|skin(1)|urinary_tract(1)	35			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			TCAAGTACGATATGACTAACA	0.294000													18	18					0	0	1	0	0
PAQR7	164091	broad.mit.edu	37	1	26189386	26189386	+	Missense_Mutation	SNP	A	A	C			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr1:26189386A>C	ENST00000374296.3	-	2	1611	c.945T>G	c.(943-945)ttT>ttG	p.F315L	RP1-125I3.2_ENST00000455431.1_RNA	NM_178422.5	NP_848509.1	Q86WK9	MPRA_HUMAN	progestin and adipoQ receptor family member VII	315					cell differentiation|multicellular organismal development|oogenesis	integral to membrane|plasma membrane	receptor activity|steroid binding			breast(3)|endometrium(1)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	9		Colorectal(325;3.46e-05)|Lung NSC(340;0.00038)|all_lung(284;0.00051)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0505)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;2.16e-25)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000724)|BRCA - Breast invasive adenocarcinoma(304;0.000965)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0136)|READ - Rectum adenocarcinoma(331;0.0649)		AGAGGCCAGAAAAGTTGTGAG	0.592000													35	63					0	0	1	0	0
FAM21C	253725	broad.mit.edu	37	10	46250521	46250521	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr10:46250521G>A	ENST00000336378.4	+	15	1496	c.1378G>A	c.(1378-1380)Gac>Aac	p.D460N	FAM21C_ENST00000537517.1_Missense_Mutation_p.D436N|FAM21C_ENST00000540872.1_Missense_Mutation_p.D460N|FAM21C_ENST00000359860.4_Missense_Mutation_p.D404N|FAM21C_ENST00000374362.2_Missense_Mutation_p.D460N	NM_015262.2	NP_056077.2	A8K5W5	A8K5W5_HUMAN	family with sequence similarity 21, member C	460										central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	28						tgatgatgatgacgaCTTTTT	0.498000													3	18					0	0	1	0	0
ACTR1A	10121	broad.mit.edu	37	10	104250323	104250323	+	Silent	SNP	T	T	C			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr10:104250323T>C	ENST00000369905.4	-	2	159	c.96A>G	c.(94-96)aaA>aaG	p.K32K	ACTR1A_ENST00000446605.2_Intron|ACTR1A_ENST00000545684.1_5'UTR|ACTR1A_ENST00000487599.1_Silent_p.K32K	NM_005736.3	NP_005727.1	P61163	ACTZ_HUMAN	ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)	32					G2/M transition of mitotic cell cycle|vesicle-mediated transport	centrosome|cytosol|dynactin complex	ATP binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)	13		Colorectal(252;0.122)		Epithelial(162;5.34e-09)|all cancers(201;1.43e-07)|BRCA - Breast invasive adenocarcinoma(275;0.222)		GAAAGCAGTATTTGGGGATCT	0.458000													15	41					0	0	1	0	0
ZBED1	9189	broad.mit.edu	37	X	2408368	2408368	+	Silent	SNP	C	C	T			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chrX:2408368C>T	ENST00000381223.4	-	2	596	c.393G>A	c.(391-393)ctG>ctA	p.L131L	ZBED1_ENST00000381218.3_Silent_p.L131L|DHRSX_ENST00000334651.5_Intron|ZBED1_ENST00000381222.2_Silent_p.L131L	NM_001171135.1|NM_001171136.1|NM_004729.3	NP_001164606.1|NP_001164607.1|NP_004720.1	O96006	ZBED1_HUMAN	zinc finger, BED-type containing 1	131						nuclear chromosome	DNA binding|metal ion binding|protein dimerization activity|transposase activity			endometrium(8)|kidney(1)|large_intestine(3)|lung(11)|prostate(1)|upper_aerodigestive_tract(1)	25		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				AGATGAGGCCCAGCACGGCGG	0.697000													39	19					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	68999986	68999986	+	Silent	SNP	T	T	C			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr8:68999986T>C	ENST00000288368.4	+	19	2332	c.2055T>C	c.(2053-2055)gaT>gaC	p.D685D	PREX2_ENST00000529398.1_3'UTR|RP11-403D15.2_ENST00000526901.1_RNA	NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	685	PDZ 2.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						ATTCAGCTGATGGACTTGGCT	0.438000													52	110					0	0	1	0	0
DGCR14	8220	broad.mit.edu	37	22	19127410	19127410	+	Silent	SNP	T	T	C			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr22:19127410T>C	ENST00000252137.6	-	4	571	c.528A>G	c.(526-528)gcA>gcG	p.A176A		NM_022719.2	NP_073210.1	Q96DF8	DGC14_HUMAN	DiGeorge syndrome critical region gene 14	176					nervous system development	catalytic step 2 spliceosome				breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|skin(1)	16	Colorectal(54;0.0993)					AAGCGTGGCGTGCCCGGCTTC	0.602000													83	123					0	0	1	0	0
SCAP	22937	broad.mit.edu	37	3	47455799	47455799	+	Silent	SNP	A	A	G			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr3:47455799A>G	ENST00000265565.5	-	22	3877	c.3465T>C	c.(3463-3465)caT>caC	p.H1155H	SCAP_ENST00000441517.2_Silent_p.H899H|SCAP_ENST00000545718.1_Silent_p.H762H	NM_012235.2	NP_036367.2	Q12770	SCAP_HUMAN	SREBF chaperone	1155	Interaction with SREBF2 (By similarity).				cholesterol metabolic process|negative regulation of cholesterol biosynthetic process|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane	unfolded protein binding			endometrium(4)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	26				BRCA - Breast invasive adenocarcinoma(193;0.000278)|KIRC - Kidney renal clear cell carcinoma(197;0.00592)|Kidney(197;0.00679)		GAGCAAACACATGGCTGACCC	0.602000													34	13					0	0	1	0	0
KRTAP15-1	254950	broad.mit.edu	37	21	31812774	31812774	+	Silent	SNP	G	G	T			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr21:31812774G>T	ENST00000334067.3	+	1	178	c.129G>T	c.(127-129)ctG>ctT	p.L43L		NM_181623.1	NP_853654.1	Q3LI76	KR151_HUMAN	keratin associated protein 15-1	43			L -> M (in dbSNP:rs2832873).			intermediate filament		p.L43L(1)		kidney(1)|large_intestine(3)|lung(6)|skin(1)	11						CCTGCCAACTGGGCTCCTCTC	0.488000													38	34					1.57351e-24	1.79347e-24	1	1	0
OR5AS1	219447	broad.mit.edu	37	11	55798145	55798145	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr11:55798145A>T	ENST00000313555.1	+	1	251	c.251A>T	c.(250-252)aAc>aTc	p.N84I		NM_001001921.1	NP_001001921.1	Q8N127	O5AS1_HUMAN	olfactory receptor, family 5, subfamily AS, member 1	84					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(7)|large_intestine(7)|liver(1)|lung(22)|ovary(3)|prostate(4)|skin(3)|stomach(1)	48	Esophageal squamous(21;0.00693)					ATGCTGGCAAACTTCTTGGCA	0.398000													15	18					0	0	1	0	0
LOC220729	220729	broad.mit.edu	37	3	197348674	197348674	+	RNA	SNP	A	A	G	rs144273946	by1000genomes	TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr3:197348674A>G	ENST00000418868.1	-	0	585					NR_003266.2																						GGCTCTGTCCACCAAATGCAC	0.478000													4	172					0	0	1	0	0
USP3	9960	broad.mit.edu	37	15	63866570	63866570	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr15:63866570A>T	ENST00000268049.7	+	12	1322	c.998A>T	c.(997-999)aAt>aTt	p.N333I	USP3_ENST00000558285.1_Missense_Mutation_p.N338I|USP3_ENST00000539772.1_Missense_Mutation_p.N106I|USP3-AS1_ENST00000560350.1_RNA|USP3_ENST00000380324.3_Missense_Mutation_p.N355I|USP3-AS1_ENST00000559861.1_RNA|USP3_ENST00000559711.1_Missense_Mutation_p.N266I|USP3-AS1_ENST00000559357.1_RNA|USP3_ENST00000540797.1_Missense_Mutation_p.N311I|USP3_ENST00000536001.1_3'UTR			Q9Y6I4	UBP3_HUMAN	ubiquitin specific peptidase 3	355					DNA repair|histone deubiquitination|mitotic cell cycle|regulation of protein stability|ubiquitin-dependent protein catabolic process	nuclear chromatin	histone binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			endometrium(3)|large_intestine(7)|lung(4)	14				GBM - Glioblastoma multiforme(80;0.0187)		CGCTCTAAGAATCAAGAAAAT	0.323000													15	29					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414373	20414373	+	Silent	SNP	G	G	A			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr9:20414373G>A	ENST00000380338.4	-	5	757	c.471C>T	c.(469-471)agC>agT	p.S157S	MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S154S|MLLT3_ENST00000355930.6_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	157	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S157S(5)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctgctactgctgc	0.527000			T	MLL	ALL								3	27					0	0	1	0	0
AMER3	205147	broad.mit.edu	37	2	131519912	131519912	+	Silent	SNP	G	G	A			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr2:131519912G>A	ENST00000423981.1	+	2	377	c.267G>A	c.(265-267)gtG>gtA	p.V89V	AMER3_ENST00000321420.4_Silent_p.V89V	NM_001105193.1|NM_001105194.1|NM_001105195.1|NM_152698.2	NP_001098663.1|NP_001098664.1|NP_001098665.1|NP_689911.2			APC membrane recruitment protein 3																		TCAAACCGGTGCGAAAGTGCA	0.662000													8	19					0	0	1	0	0
BMP2	650	broad.mit.edu	37	20	6751021	6751021	+	Missense_Mutation	SNP	A	A	G	rs79417223		TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr20:6751021A>G	ENST00000378827.4	+	2	1467	c.248A>G	c.(247-249)tAt>tGt	p.Y83C		NM_001200.2	NP_001191.1	P12643	BMP2_HUMAN	bone morphogenetic protein 2	83					BMP signaling pathway involved in heart induction|bone mineralization involved in bone maturation|cardiac cell differentiation|cardiac epithelial to mesenchymal transition|cartilage development|growth|negative regulation of cell cycle|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|pathway-restricted SMAD protein phosphorylation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cartilage development|positive regulation of endothelial cell proliferation|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of phosphatase activity|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	activin receptor activity, type II|BMP receptor binding|cytokine activity|growth factor activity|phosphatase activator activity|protein heterodimerization activity|SMAD binding|transforming growth factor beta receptor binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)	13					Simvastatin(DB00641)	CTAGACCTGTATCGCAGGCAC	0.647000													13	33					0	0	1	0	0
TCF20	6942	broad.mit.edu	37	22	42605671	42605671	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr22:42605671T>C	ENST00000359486.3	-	1	5777	c.5641A>G	c.(5641-5643)Ata>Gta	p.I1881V	TCF20_ENST00000335626.4_Missense_Mutation_p.I1881V|TCF20_ENST00000404876.1_Missense_Mutation_p.I182V	NM_005650.1	NP_005641.1	Q9UGU0	TCF20_HUMAN	transcription factor 20 (AR1)	1881					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(13)|lung(22)|ovary(5)|prostate(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(5)	66						TCTCTGGCTATTTCCAGCGCT	0.433000													72	99					0	0	1	0	0
FAM21C	253725	broad.mit.edu	37	10	46250493	46250493	+	Silent	SNP	C	C	G	rs28673841		TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr10:46250493C>G	ENST00000336378.4	+	15	1468	c.1350C>G	c.(1348-1350)ctC>ctG	p.L450L	FAM21C_ENST00000537517.1_Silent_p.L426L|FAM21C_ENST00000540872.1_Silent_p.L450L|FAM21C_ENST00000359860.4_Silent_p.L394L|FAM21C_ENST00000374362.2_Silent_p.L450L	NM_015262.2	NP_056077.2	A8K5W5	A8K5W5_HUMAN	family with sequence similarity 21, member C	450										central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	28						CCACTGGCCTCTTtgatgatg	0.522000													8	25					0	0	1	0	0
SMCHD1	23347	broad.mit.edu	37	18	2732289	2732289	+	Missense_Mutation	SNP	G	G	T	rs150408627	by1000genomes	TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr18:2732289G>T	ENST00000320876.6	+	25	3413	c.3075G>T	c.(3073-3075)gaG>gaT	p.E1025D	SMCHD1_ENST00000261598.8_Missense_Mutation_p.E1025D|RP11-703M24.5_ENST00000583546.1_RNA	NM_015295.2	NP_056110.2	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible hinge domain containing 1	1025					chromosome organization		ATP binding			NS(3)|breast(3)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(16)|lung(15)|pancreas(1)	45						CACCTGTGGAGAAGACTATTA	0.373000													28	49					1.32003e-05	1.42779e-05	1	1	0
KIF15	56992	broad.mit.edu	37	3	44856411	44856411	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr3:44856411A>G	ENST00000326047.4	+	20	2541	c.2392A>G	c.(2392-2394)Agt>Ggt	p.S798G	KIF15_ENST00000425755.1_Missense_Mutation_p.S433G	NM_020242.2	NP_064627.1	Q9NS87	KIF15_HUMAN	kinesin family member 15	798					blood coagulation|cell proliferation|microtubule-based movement|mitosis	centrosome|cytosol|microtubule|plus-end kinesin complex|spindle	ATP binding|DNA binding|microtubule motor activity			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|liver(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(5)	36				BRCA - Breast invasive adenocarcinoma(193;0.0099)|KIRC - Kidney renal clear cell carcinoma(197;0.0564)|Kidney(197;0.0707)		AGTTTTGAAAAGTGAGGTACA	0.353000													30	11					0	0	1	0	0
PLEKHG7	440107	broad.mit.edu	37	12	93150134	93150134	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr12:93150134C>G	ENST00000344636.3	+	8	851	c.667C>G	c.(667-669)Cac>Gac	p.H223D		NM_001004330.2	NP_001004330.1	Q6ZR37	PKHG7_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 7	223	PH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)	17						AACCAGCAGACACCTTCTCTA	0.368000													13	47					0	0	1	0	0
FRMD4A	55691	broad.mit.edu	37	10	13701485	13701485	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr10:13701485T>C	ENST00000357447.2	-	21	2272	c.1904A>G	c.(1903-1905)cAc>cGc	p.H635R	FRMD4A_ENST00000358621.4_Missense_Mutation_p.H620R|FRMD4A_ENST00000378503.1_Missense_Mutation_p.H635R	NM_018027.3	NP_060497.3	Q9P2Q2	FRM4A_HUMAN	FERM domain containing 4A	635	Ser-rich.					cytoplasm|cytoskeleton	binding			breast(4)|endometrium(9)|kidney(2)|large_intestine(11)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	41						GAAGCGCTTGTGGCTGCTGCA	0.632000													17	58					0	0	1	0	0
SPEG	10290	broad.mit.edu	37	2	220354174	220354174	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr2:220354174C>A	ENST00000312358.7	+	36	8566	c.8434C>A	c.(8434-8436)Ccc>Acc	p.P2812T	AC053503.11_ENST00000429882.1_RNA|SPEG_ENST00000485813.1_3'UTR	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	2812	Pro-rich.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		TCCTGCTGCCCCCACACCCCC	0.672000													59	61					1.93748e-29	2.25684e-29	1	1	0
MFSD3	113655	broad.mit.edu	37	8	145734848	145734848	+	Silent	SNP	G	G	A			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr8:145734848G>A	ENST00000301327.4	+	1	392	c.132G>A	c.(130-132)aaG>aaA	p.K44K		NM_138431.1	NP_612440.1	Q96ES6	MFSD3_HUMAN	major facilitator superfamily domain containing 3	44	Leu-rich.				transmembrane transport	integral to membrane				central_nervous_system(2)|endometrium(1)|kidney(1)|lung(4)	8	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			GGCTGGCCAAGGTTCTGTACG	0.736000													3	4					0	0	1	0	0
NCOR2	9612	broad.mit.edu	37	12	124859003	124859003	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr12:124859003T>C	ENST00000356219.3	-	20	2329	c.2174A>G	c.(2173-2175)cAt>cGt	p.H725R	NCOR2_ENST00000397355.1_Intron|NCOR2_ENST00000404621.1_Intron|NCOR2_ENST00000405201.1_Missense_Mutation_p.H725R|NCOR2_ENST00000429285.2_Intron|NCOR2_ENST00000404121.2_Intron	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	725					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		cccagaggcatgtaaggctgg	0.647000													18	11					0	0	1	0	0
GTF3C3	9330	broad.mit.edu	37	2	197641346	197641346	+	Silent	SNP	T	T	C			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr2:197641346T>C	ENST00000263956.3	-	11	1487	c.1398A>G	c.(1396-1398)ttA>ttG	p.L466L		NM_012086.4	NP_036218.1	Q9Y5Q9	TF3C3_HUMAN	general transcription factor IIIC, polypeptide 3, 102kDa	466						transcription factor TFIIIC complex	DNA binding|protein binding			breast(4)|endometrium(3)|kidney(1)|large_intestine(9)|lung(5)|ovary(3)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	33						CTAAGGCCTTTAAACATTCTA	0.378000													8	75					0	0	1	0	0
TMEM132D	121256	broad.mit.edu	37	12	130185052	130185052	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr12:130185052G>A	ENST00000422113.2	-	2	597	c.271C>T	c.(271-273)Cct>Tct	p.P91S		NM_133448.2	NP_597705.2	Q14C87	T132D_HUMAN	transmembrane protein 132D	91						integral to membrane		p.P91S(1)		NS(1)|breast(6)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(33)|liver(1)|lung(69)|ovary(10)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(2)	152	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		TTGAGGACAGGCAGCCTCCTG	0.512000													17	37					0	0	1	0	0
IGKV3D-11	28876	broad.mit.edu	37	2	90212076	90212076	+	RNA	SNP	C	C	A			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr2:90212076C>A	ENST00000390277.2	+	0	265																											TAGCCTGGTACCAGCAGAAAC	0.597000													50	99					2.68985e-26	3.09918e-26	1	1	0
CYP4A11	1579	broad.mit.edu	37	1	47398680	47398680	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr1:47398680T>C	ENST00000310638.4	-	10	1293	c.1262A>G	c.(1261-1263)aAc>aGc	p.N421S	CYP4A11_ENST00000475477.1_Intron|CYP4A11_ENST00000371904.4_Missense_Mutation_p.N422S|CYP4A11_ENST00000371905.1_Missense_Mutation_p.N421S	NM_000778.3	NP_000769.2	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 11	421					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			endometrium(2)|kidney(5)|large_intestine(6)|lung(6)|ovary(5)|prostate(3)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	36					NADH(DB00157)	CACTTTTGGGTTGTGGTGAAG	0.517000													12	391					0	0	1	0	0
PDE10A	10846	broad.mit.edu	37	6	165792844	165792844	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr6:165792844G>C	ENST00000366882.1	-	19	1948	c.1794C>G	c.(1792-1794)caC>caG	p.H598Q	PDE10A_ENST00000354448.4_Missense_Mutation_p.H598Q|PDE10A_ENST00000539869.2_Missense_Mutation_p.H608Q			Q9Y233	PDE10_HUMAN	phosphodiesterase 10A	598					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			breast(4)|endometrium(5)|kidney(1)|large_intestine(13)|liver(1)|lung(39)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	71		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	AGAAGATATTGTGCCCTTCCA	0.378000													20	33					0	0	1	0	0
TSPAN3	10099	broad.mit.edu	37	15	77346572	77346572	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr15:77346572T>C	ENST00000267970.4	-	4	653	c.380A>G	c.(379-381)aAt>aGt	p.N127S	TSPAN3_ENST00000558394.1_5'UTR|TSPAN3_ENST00000559494.1_Missense_Mutation_p.N38S|TSPAN3_ENST00000424443.3_Missense_Mutation_p.N63S|TSPAN3_ENST00000346495.2_Missense_Mutation_p.N102S|TSPAN3_ENST00000558745.1_5'UTR|TSPAN3_ENST00000561277.1_5'UTR	NM_001168412.1|NM_005724.5|NM_198902.2	NP_001161884.1|NP_005715.1|NP_944492.1	O60637	TSN3_HUMAN	tetraspanin 3	127						integral to membrane				kidney(1)|large_intestine(2)|lung(6)|urinary_tract(1)	10				all cancers(203;1.14e-19)		GTTGGTTCCATTGTAGGTCTT	0.413000													24	32					0	0	1	0	0
UST	10090	broad.mit.edu	37	6	149395184	149395184	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr6:149395184A>G	ENST00000367463.4	+	8	1256	c.1153A>G	c.(1153-1155)Acc>Gcc	p.T385A	UST_ENST00000466695.1_3'UTR	NM_005715.2	NP_005706.1	Q9Y2C2	UST_HUMAN	uronyl-2-sulfotransferase	385					protein sulfation	Golgi membrane|integral to membrane	sulfotransferase activity			breast(1)|endometrium(3)|large_intestine(4)|lung(2)|ovary(2)	12		Ovarian(120;0.0907)		OV - Ovarian serous cystadenocarcinoma(155;1.78e-10)|GBM - Glioblastoma multiforme(68;0.138)		TCCACTGGAAACCGAGGAGCC	0.488000													5	75					0	0	1	0	0
ACTN4	81	broad.mit.edu	37	19	39214357	39214357	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr19:39214357C>A	ENST00000252699.2	+	13	1622	c.1546C>A	c.(1546-1548)Ctg>Atg	p.L516M	ACTN4_ENST00000424234.2_Missense_Mutation_p.L126M|ACTN4_ENST00000390009.3_Missense_Mutation_p.L297M	NM_004924.4	NP_004915.2	O43707	ACTN4_HUMAN	actinin, alpha 4	516					platelet activation|platelet degranulation|positive regulation of cellular component movement|positive regulation of sodium:hydrogen antiporter activity|protein transport|regulation of apoptosis	extracellular region|nucleolus|perinuclear region of cytoplasm|platelet alpha granule lumen|protein complex|pseudopodium|ribonucleoprotein complex	actin filament binding|calcium ion binding|integrin binding|nucleoside binding|protein homodimerization activity			NS(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|urinary_tract(3)	30	all_cancers(60;1.57e-05)|Ovarian(47;0.103)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			CAGGGAAGCCCTGGAGGTGAG	0.627000													6	8					0.00116845	0.00121427	1	1	0
ANKHD1	54882	broad.mit.edu	37	5	139819838	139819838	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr5:139819838A>G	ENST00000297183.6	+	4	876	c.752A>G	c.(751-753)tAt>tGt	p.Y251C	ANKHD1-EIF4EBP3_ENST00000532219.1_Missense_Mutation_p.Y251C|ANKHD1_ENST00000360839.2_Missense_Mutation_p.Y251C|ANKHD1_ENST00000394722.3_Missense_Mutation_p.Y240C|ANKHD1_ENST00000394723.3_Missense_Mutation_p.Y251C	NM_020690.5	NP_065741.3			ankyrin repeat and KH domain containing 1											breast(2)|endometrium(8)|kidney(6)|large_intestine(14)|lung(18)|ovary(5)|prostate(2)|skin(3)|urinary_tract(2)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCAGGGTATTATGAATTAGCA	0.323000													42	23					0	0	1	0	0
ZNF343	79175	broad.mit.edu	37	20	2463924	2463924	+	Silent	SNP	T	T	C			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr20:2463924T>C	ENST00000278772.4	-	6	2170	c.1683A>G	c.(1681-1683)aaA>aaG	p.K561K	RP4-734P14.4_ENST00000461548.1_Intron	NM_024325.4	NP_077301.4	Q6P1L6	ZN343_HUMAN	zinc finger protein 343	561					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(11)|skin(4)|upper_aerodigestive_tract(1)	25						GGAGGAGTGATTTCCGGCTAA	0.502000													29	47					0	0	1	0	0
FAM45A	404636	broad.mit.edu	37	10	120889085	120889085	+	Silent	SNP	G	G	A			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr10:120889085G>A	ENST00000361432.2	+	7	779	c.753G>A	c.(751-753)gtG>gtA	p.V251V	FAM45A_ENST00000544016.1_Silent_p.V100V|FAM45A_ENST00000489988.1_3'UTR|FAM45A_ENST00000535029.1_3'UTR	NM_207009.2	NP_996892.1	Q8TCE6	FA45A_HUMAN	family with sequence similarity 45, member A	251										breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|ovary(2)|urinary_tract(1)	14		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0293)		TCTATGATGTGTTTGTGAATC	0.433000													13	30					0	0	1	0	0
RGPD4	285190	broad.mit.edu	37	2	108488115	108488115	+	Nonsense_Mutation	SNP	G	G	T			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr2:108488115G>T	ENST00000408999.3	+	20	3732	c.3655G>T	c.(3655-3657)Gaa>Taa	p.E1219*	RGPD4_ENST00000354986.4_Nonsense_Mutation_p.E1219*	NM_182588.2	NP_872394.2	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1219					intracellular transport		binding			breast(1)|endometrium(7)|kidney(4)|lung(23)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(3)	43						AGTCACTGAGGAAGAAAATAA	0.423000													7	185					1.58986e-06	1.75547e-06	1	1	0
GPR128	84873	broad.mit.edu	37	3	100413810	100413810	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr3:100413810C>G	ENST00000273352.3	+	16	2627	c.2359C>G	c.(2359-2361)Ctc>Gtc	p.L787V	GPR128_ENST00000475887.1_Missense_Mutation_p.L492V|GPR128_ENST00000481506.1_3'UTR	NM_032787.2	NP_116176.2	Q96K78	GP128_HUMAN	G protein-coupled receptor 128	787					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|liver(2)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	56						GGAAATCACACTCTCTGAAAG	0.413000													25	53					0	0	1	0	0
AKR1D1	6718	broad.mit.edu	37	7	137801398	137801398	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr7:137801398A>T	ENST00000242375.3	+	9	1013	c.971A>T	c.(970-972)gAt>gTt	p.D324V	AKR1D1_ENST00000411726.2_Missense_Mutation_p.D283V|AKR1D1_ENST00000432161.1_3'UTR|AKR1D1_ENST00000468877.2_3'UTR	NM_005989.3	NP_005980.1	P51857	AK1D1_HUMAN	aldo-keto reductase family 1, member D1	324					androgen metabolic process|bile acid biosynthetic process|bile acid catabolic process|C21-steroid hormone metabolic process|cholesterol catabolic process|digestion	cytosol	aldo-keto reductase (NADP) activity|delta4-3-oxosteroid 5beta-reductase activity|steroid binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(14)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	23						CCATTTCATGATGAATACTGA	0.448000													30	33					0	0	1	0	0
ULK1	8408	broad.mit.edu	37	12	132393211	132393211	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr12:132393211C>A	ENST00000321867.4	+	6	690	c.339C>A	c.(337-339)gaC>gaA	p.D113E		NM_003565.2	NP_003556.1	O75385	ULK1_HUMAN	unc-51 like autophagy activating kinase 1	113	Protein kinase.				autophagy|protein localization|regulation of autophagy	autophagic vacuole|cytosol|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	ATP binding|protein complex binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(11)|ovary(1)|prostate(2)|skin(2)|urinary_tract(2)	29	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.07e-08)|Epithelial(86;2.56e-07)|all cancers(50;3.01e-07)		TGAGCGAGGACACCATCAGGC	0.677000													6	13					0.00116845	0.00121427	1	1	0
ZNF546	339327	broad.mit.edu	37	19	40504315	40504315	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr19:40504315A>G	ENST00000347077.4	+	3	298	c.82A>G	c.(82-84)Atg>Gtg	p.M28V	ZNF546_ENST00000600094.1_Intron|ZNF546_ENST00000596894.1_Intron	NM_178544.3	NP_848639.2	Q86UE3	ZN546_HUMAN	zinc finger protein 546	28					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(15)|lung(6)|ovary(3)|skin(2)|upper_aerodigestive_tract(3)	34	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					ACTTTCTATAATGGTAGAGAA	0.388000													5	28					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113516155	113516155	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr8:113516155G>T	ENST00000297405.5	-	30	5191	c.4947C>A	c.(4945-4947)gaC>gaA	p.D1649E	CSMD3_ENST00000455883.2_Missense_Mutation_p.D1545E|CSMD3_ENST00000343508.3_Missense_Mutation_p.D1609E|CSMD3_ENST00000352409.3_Missense_Mutation_p.D1649E	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1649	CUB 9.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						GGCTATTACTGTCTGGTCCAT	0.358000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			22	37					5.26018e-13	5.93169e-13	1	1	0
TMEM200A	114801	broad.mit.edu	37	6	130762093	130762093	+	Missense_Mutation	SNP	A	A	C			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr6:130762093A>C	ENST00000392429.1	+	2	2904	c.526A>C	c.(526-528)Aag>Cag	p.K176Q	TMEM200A_ENST00000545622.1_Missense_Mutation_p.K176Q|TMEM200A_ENST00000296978.3_Missense_Mutation_p.K176Q	NM_052913.2	NP_443145.1	Q86VY9	T200A_HUMAN	transmembrane protein 200A	176						integral to membrane				NS(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(30)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		GCTAAGAATCAAGGAGCAAAG	0.428000													27	51					0	0	1	0	0
HUWE1	10075	broad.mit.edu	37	X	53600715	53600715	+	Nonsense_Mutation	SNP	T	T	A			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chrX:53600715T>A	ENST00000342160.3	-	46	6764	c.6307A>T	c.(6307-6309)Aaa>Taa	p.K2103*	HUWE1_ENST00000262854.6_Nonsense_Mutation_p.K2103*			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	2103					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						ATTACCTCTTTGATCAGTTCA	0.458000													16	29					0	0	1	0	0
HERC6	55008	broad.mit.edu	37	4	89314703	89314703	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr4:89314703G>A	ENST00000380265.5	+	5	911	c.728G>A	c.(727-729)tGt>tAt	p.C243Y	HERC6_ENST00000264346.7_Missense_Mutation_p.C243Y|HERC6_ENST00000273960.3_Missense_Mutation_p.C243Y	NM_001165136.1	NP_001158608.1	Q8IVU3	HERC6_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 6	243					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytosol	ubiquitin-protein ligase activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)	11		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000222)		TATATCAGCTGTGGTGATGCA	0.403000													5	13					0	0	1	0	0
GDF3	9573	broad.mit.edu	37	12	7842783	7842783	+	Silent	SNP	G	G	A			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr12:7842783G>A	ENST00000329913.3	-	2	833	c.786C>T	c.(784-786)aaC>aaT	p.N262N		NM_020634.1	NP_065685.1	Q9NR23	GDF3_HUMAN	growth differentiation factor 3	262					eye development|growth|skeletal system development	extracellular space	cytokine activity|growth factor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(7)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	28						GGTGGCAGAGGTTCTTACAAG	0.537000													42	58					0	0	1	0	0
SLAMF1	6504	broad.mit.edu	37	1	160589601	160589601	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr1:160589601delT	ENST00000302035.6	-	5	1178	c.829delA	c.(829-831)gcfs	p.S277fs	SLAMF1_ENST00000235739.5_Frame_Shift_Del_p.S247fs|SLAMF1_ENST00000355199.3_Frame_Shift_Del_p.S277fs|SLAMF1_ENST00000538290.1_Intron	NM_003037.2	NP_003028.1	Q13291	SLAF1_HUMAN	signaling lymphocytic activation molecule family member 1	277					interspecies interaction between organisms|lymphocyte activation|positive regulation of cell proliferation	integral to membrane	antigen binding|transmembrane receptor activity			breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	25	all_cancers(52;4.94e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			ATCGTAAGGCTTTTTTTTTCC	0.433													8	155	---	---	---	---					
COL26A1	136227	broad.mit.edu	37	7	101183401	101183401	+	RNA	DEL	C	C	-			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr7:101183401delC	ENST00000313669.7	+	0	796				COL26A1_ENST00000397927.3_RNA|COL26A1_ENST00000528707.1_RNA	NM_133457.2	NP_597714.2			collagen, type XXVI, alpha 1																		CCCAGGGCCTCCCTAGAGAGG	0.557													8	9	---	---	---	---					
P4HA1	5033	broad.mit.edu	37	10	74813231	74813232	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr10:74813231_74813232delAG	ENST00000412021.2	-	7	913_914	c.580_581delCT	c.(580-582)gfs	p.L194fs	P4HA1_ENST00000307116.2_Frame_Shift_Del_p.L194fs|P4HA1_ENST00000440381.1_Frame_Shift_Del_p.L194fs|P4HA1_ENST00000373008.2_Frame_Shift_Del_p.L194fs|P4HA1_ENST00000394890.2_Frame_Shift_Del_p.L194fs|P4HA1_ENST00000263556.3_Frame_Shift_Del_p.L194fs	NM_001142595.1	NP_001136067.1	P13674	P4HA1_HUMAN	prolyl 4-hydroxylase, alpha polypeptide I	194						endoplasmic reticulum lumen|mitochondrion	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 4-dioxygenase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)	15	Prostate(51;0.0198)				Hydralazine(DB01275)|L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	GCCTTCATCCAGTTGCCTTAGG	0.446													49	71	---	---	---	---					
KMT2D	8085	broad.mit.edu	37	12	49447385	49447385	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr12:49447385delA	ENST00000301067.7	-	6	712	c.713delT	c.(712-714)tgfs	p.L238fs		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		CAGGTCACACAACTCCCCTGG	0.597													9	4	---	---	---	---					
TP53	7157	broad.mit.edu	37	17	7576862	7576863	+	Frame_Shift_Ins	INS	-	-	A			TCGA-F7-A61W-01A-11D-A28R-08	TCGA-F7-A61W-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed0da491-dc84-4ed1-8339-e12bf5c9503f	ac306330-1113-45d8-bb1f-029bc54aff50	g.chr17:7576862_7576863insA	ENST00000420246.2	-	9	1115_1116	c.983_984insT	c.(982-984)tacfs	p.Y328fs	TP53_ENST00000359597.4_Frame_Shift_Ins_p.Y328fs|TP53_ENST00000455263.2_Frame_Shift_Ins_p.Y328fs|TP53_ENST00000413465.2_Intron|TP53_ENST00000445888.2_Frame_Shift_Ins_p.Y328fs|TP53_ENST00000269305.4_Frame_Shift_Ins_p.Y328fs	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	328	Interaction with CARM1.|Interaction with HIPK1 (By similarity).|Interaction with HIPK2.|Oligomerization.		F -> L (in a sporadic cancer; somatic mutation).|F -> S (in sporadic cancers; somatic mutation).|F -> V (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(8)|p.T329fs*8(3)|p.F328F(1)|p.T329fs*21(1)|p.F328S(1)|p.?(1)|p.F328fs*9(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCTGAAGGGTGAAATATTCTCC	0.441		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			90	22	---	---	---	---