Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CDC5L	988	broad.mit.edu	37	6	44387238	44387238	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr6:44387238G>T	ENST00000371477.3	+	9	1444	c.1145G>T	c.(1144-1146)gGa>gTa	p.G382V		NM_001253.3	NP_001244.1	Q99459	CDC5L_HUMAN	cell division cycle 5-like	382	Interaction with PPP1R8.				cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	catalytic step 2 spliceosome|cytoplasm|nuclear speck|nucleolus	DNA binding|RNA binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(1)|skin(4)	29	all_lung(25;0.00433)|Ovarian(13;0.0273)|all_hematologic(164;0.208)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			TTGAAAGGTGGACTTAATACC	0.443000													19	52					1.01871e-10	1.10361e-10	1	1	0
ESR1	2099	broad.mit.edu	37	6	152163816	152163816	+	Silent	SNP	C	C	A			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr6:152163816C>A	ENST00000440973.1	+	4	907	c.537C>A	c.(535-537)gcC>gcA	p.A179A	ESR1_ENST00000443427.1_Silent_p.A179A|ESR1_ENST00000206249.3_Silent_p.A179A|ESR1_ENST00000338799.5_Silent_p.A179A|ESR1_ENST00000456483.2_Silent_p.A179A|ESR1_ENST00000406599.1_Intron|ESR1_ENST00000544394.1_Silent_p.A6A	NM_001122742.1	NP_001116214.1	P03372	ESR1_HUMAN	estrogen receptor 1	179	Modulating; mediates interaction with MACROD1.				positive regulation of retinoic acid receptor signaling pathway|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to estradiol stimulus	chromatin remodeling complex|cytoplasm|nucleoplasm	beta-catenin binding|enzyme binding|estrogen receptor activity|estrogen response element binding|nitric-oxide synthase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(11)|lung(19)|ovary(1)|prostate(2)|skin(1)	49		Ovarian(120;0.0448)	BRCA - Breast invasive adenocarcinoma(37;0.0841)	OV - Ovarian serous cystadenocarcinoma(155;4.55e-10)	Chlorotrianisene(DB00269)|Clomifene(DB00882)|Conjugated Estrogens(DB00286)|Danazol(DB01406)|Desogestrel(DB00304)|Dienestrol(DB00890)|Diethylstilbestrol(DB00255)|Dromostanolone(DB00858)|Drospirenone(DB01395)|Estradiol(DB00783)|Estramustine(DB01196)|Estriol(DB04573)|Estrone(DB00655)|Ethinyl Estradiol(DB00977)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Fluoxymesterone(DB01185)|Fulvestrant(DB00947)|Letrozole(DB01006)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Melatonin(DB01065)|Mestranol(DB01357)|Naloxone(DB01183)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)|Quinestrol(DB04575)|Raloxifene(DB00481)|Tamoxifen(DB00675)|Toremifene(DB00539)	TGGAATCTGCCAAGGAGACTC	0.498000													12	50					0.00010058	0.000102151	1	1	0
HSD3B7	80270	broad.mit.edu	37	16	30998261	30998261	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr16:30998261G>A	ENST00000297679.5	+	6	725	c.632G>A	c.(631-633)cGc>cAc	p.R211H	HSD3B7_ENST00000353250.5_Intron|HSD3B7_ENST00000262520.6_Intron	NM_025193.3	NP_079469.2	Q9H2F3	3BHS7_HUMAN	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7	211					bile acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity	p.R211H(1)		central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12						CAGGGCCTGCGCCTGGGAGGT	0.662000													33	43					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55582405	55582405	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr10:55582405G>A	ENST00000361849.3	-	34	5481	c.5087C>T	c.(5086-5088)gCt>gTt	p.A1696V	PCDH15_ENST00000395433.1_Missense_Mutation_p.A1671V|PCDH15_ENST00000395446.1_Intron|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000409834.1_Intron|PCDH15_ENST00000395432.2_Missense_Mutation_p.A1654V|PCDH15_ENST00000414778.1_Intron|PCDH15_ENST00000373965.2_Intron|PCDH15_ENST00000395445.1_Intron|PCDH15_ENST00000395430.1_Missense_Mutation_p.A1691V|PCDH15_ENST00000463095.1_5'UTR|PCDH15_ENST00000320301.6_Missense_Mutation_p.A1694V|PCDH15_ENST00000395438.1_Intron|PCDH15_ENST00000373957.3_Intron|PCDH15_ENST00000437009.1_Missense_Mutation_p.A1625V|PCDH15_ENST00000395440.1_Intron	NM_001142763.1|NM_001142764.1|NM_001142765.1|NM_001142768.1	NP_001136235.1|NP_001136236.1|NP_001136237.1|NP_001136240.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	1694					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				GGAACACTCAGCAGGAGAACT	0.418000										HNSCC(58;0.16)			19	54					0	0	1	0	0
ERC2	26059	broad.mit.edu	37	3	56468653	56468653	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr3:56468653G>C	ENST00000288221.6	-	2	638	c.383C>G	c.(382-384)tCc>tGc	p.S128C		NM_015576.1	NP_056391.1	O15083	ERC2_HUMAN	ELKS/RAB6-interacting/CAST family member 2	128						cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			breast(2)|endometrium(5)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|urinary_tract(1)	31				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		GTGATGATGGGATGAGCCAGT	0.507000													55	49					0	0	1	0	0
SMCHD1	23347	broad.mit.edu	37	18	2718395	2718395	+	Silent	SNP	A	A	G			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr18:2718395A>G	ENST00000320876.6	+	19	2759	c.2421A>G	c.(2419-2421)agA>agG	p.R807R	RP11-703M24.5_ENST00000583546.1_RNA|SMCHD1_ENST00000261598.8_Silent_p.R807R	NM_015295.2	NP_056110.2	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible hinge domain containing 1	807					chromosome organization		ATP binding			NS(3)|breast(3)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(16)|lung(15)|pancreas(1)	45						ATGCAGGAAGACCACTACCAT	0.299000													26	276					0	0	1	0	0
ZPLD1	131368	broad.mit.edu	37	3	102171763	102171763	+	Splice_Site	SNP	C	C	A			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr3:102171763C>A	ENST00000306176.1	+	3	255	c.154_splice	c.e3-1	p.A52_splice	ZPLD1_ENST00000491959.1_Splice_Site_p.A36_splice|ZPLD1_ENST00000466937.1_Splice_Site_p.A36_splice	NM_175056.1	NP_778226.1	Q8TCW7	ZPLD1_HUMAN	zona pellucida-like domain containing 1	36	ZP.					integral to membrane				central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(18)|ovary(2)|skin(3)	35						TTTATTTCAGCTGAAAGAGAC	0.328000													26	14					2.48779e-11	2.71776e-11	1	1	0
ST6GALNAC5	81849	broad.mit.edu	37	1	77509973	77509973	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr1:77509973C>A	ENST00000477717.1	+	3	581	c.346C>A	c.(346-348)Cag>Aag	p.Q116K		NM_030965.1	NP_112227.1	Q9BVH7	SIA7E_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5	116					protein glycosylation	integral to Golgi membrane	sialyltransferase activity			endometrium(2)|kidney(1)|large_intestine(6)|lung(5)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)	18						CCAGATTGACCAGACAGAGTG	0.617000													21	24					7.41877e-09	7.90525e-09	1	1	0
RAP1GDS1	5910	broad.mit.edu	37	4	99313207	99313207	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr4:99313207G>T	ENST00000408927.3	+	6	726	c.613G>T	c.(613-615)Gca>Tca	p.A205S	RAP1GDS1_ENST00000380158.4_Missense_Mutation_p.A157S|RAP1GDS1_ENST00000408900.3_Missense_Mutation_p.A156S|RAP1GDS1_ENST00000453712.2_Missense_Mutation_p.A206S|RAP1GDS1_ENST00000264572.7_Intron|RAP1GDS1_ENST00000339360.5_Missense_Mutation_p.A206S	NM_001100426.1|NM_001100427.1|NM_021159.4	NP_001093896.1|NP_001093897.1|NP_066982.3	P52306	GDS1_HUMAN	RAP1, GTP-GDP dissociation stimulator 1	205							binding|GTPase activator activity			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)	28				OV - Ovarian serous cystadenocarcinoma(123;2.9e-07)|LUSC - Lung squamous cell carcinoma(1;0.0253)|Lung(1;0.0576)		GTGTCTTGTTGCATTTGGTAA	0.343000			T	NUP98	T-ALL								9	24					3.09899e-07	3.22294e-07	1	1	0
ATAD2	29028	broad.mit.edu	37	8	124382228	124382228	+	Missense_Mutation	SNP	T	T	A			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr8:124382228T>A	ENST00000287394.5	-	7	871	c.764A>T	c.(763-765)gAt>gTt	p.D255V	ATAD2_ENST00000521903.1_5'UTR	NM_014109.3	NP_054828.2	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	255	Asp-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|lung(16)|ovary(3)|prostate(3)|skin(1)|urinary_tract(2)	48	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			ttcaccatcatcttcatGTTC	0.348000													29	23					0	0	1	0	0
GRIA2	2891	broad.mit.edu	37	4	158281241	158281241	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr4:158281241G>T	ENST00000296526.7	+	13	2562	c.2237G>T	c.(2236-2238)gGa>gTa	p.G746V	GRIA2_ENST00000507898.1_Missense_Mutation_p.G699V|GRIA2_ENST00000449365.1_Missense_Mutation_p.G699V|GRIA2_ENST00000264426.9_Missense_Mutation_p.G746V|GRIA2_ENST00000393815.2_Missense_Mutation_p.G699V	NM_000826.3	NP_000817.2	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2	746					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(2)|lung(32)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	79	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	AAAGTTGGTGGAAACCTGGAT	0.438000													10	20					2.17888e-05	2.23035e-05	1	1	0
DNAH9	1770	broad.mit.edu	37	17	11835376	11835376	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr17:11835376C>T	ENST00000262442.3	+	64	12219	c.12151C>T	c.(12151-12153)Ctc>Ttc	p.L4051F	DNAH9_ENST00000396001.2_Missense_Mutation_p.L363F|DNAH9_ENST00000454412.2_Missense_Mutation_p.L3975F	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	4051	AAA 6 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		TAAGAGCATCCTCTTTGCTCT	0.493000													86	178					0	0	1	0	0
ANKRD17	26057	broad.mit.edu	37	4	74014589	74014589	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr4:74014589G>A	ENST00000358602.4	-	8	1624	c.1508C>T	c.(1507-1509)cCa>cTa	p.P503L	ANKRD17_ENST00000514252.1_5'UTR|ANKRD17_ENST00000509867.2_Missense_Mutation_p.P390L|ANKRD17_ENST00000330838.6_Missense_Mutation_p.P503L	NM_032217.3	NP_115593.3	O75179	ANR17_HUMAN	ankyrin repeat domain 17	503					interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			NS(3)|breast(2)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(39)|ovary(6)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)	96	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TTCCATCAATGGTGTATAACC	0.423000													20	42					0	0	1	0	0
TAOK1	57551	broad.mit.edu	37	17	27825376	27825376	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr17:27825376G>A	ENST00000261716.3	+	12	1559	c.1040G>A	c.(1039-1041)aGt>aAt	p.S347N	TAOK1_ENST00000536202.1_Missense_Mutation_p.S347N	NM_020791.2	NP_065842.1	Q7L7X3	TAOK1_HUMAN	TAO kinase 1	347	Ser-rich.				mitotic prometaphase	cytosol|intracellular membrane-bounded organelle	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(14)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	28			Colorectal(6;0.198)			ACAGTTAATAGTGTTGGAAGT	0.408000													17	49					0	0	1	0	0
HAPLN1	1404	broad.mit.edu	37	5	82937489	82937489	+	Missense_Mutation	SNP	T	T	A			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr5:82937489T>A	ENST00000274341.4	-	5	1741	c.891A>T	c.(889-891)aaA>aaT	p.K297N		NM_001884.3	NP_001875.1	P10915	HPLN1_HUMAN	hyaluronan and proteoglycan link protein 1	297	Link 2.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(12)|liver(1)|lung(15)|ovary(1)|prostate(1)|skin(1)	34		Lung NSC(167;0.0484)|all_lung(232;0.0522)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;7.82e-42)|Epithelial(54;5.88e-35)|all cancers(79;1.14e-29)		ATCCGAGAATTTTCCAGGCAG	0.547000													5	190					0	0	1	0	0
ZNF347	84671	broad.mit.edu	37	19	53644901	53644901	+	Missense_Mutation	SNP	T	T	A			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr19:53644901T>A	ENST00000452676.2	-	5	1609	c.1183A>T	c.(1183-1185)Acc>Tcc	p.T395S	ZNF347_ENST00000334197.7_Missense_Mutation_p.T394S|ZNF347_ENST00000601469.2_Missense_Mutation_p.T395S|ZNF347_ENST00000601804.1_Intron	NM_001172674.1	NP_001166145.1	Q96SE7	ZN347_HUMAN	zinc finger protein 347	394					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(6)|lung(8)|prostate(3)|skin(1)	23				GBM - Glioblastoma multiforme(134;0.0179)		CCACTGTGGGTTGCCTGATGG	0.413000													32	35					0	0	1	0	0
SALL2	6297	broad.mit.edu	37	14	21991048	21991048	+	Silent	SNP	C	C	T			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr14:21991048C>T	ENST00000327430.3	-	2	3108	c.2814G>A	c.(2812-2814)ccG>ccA	p.P938P	SALL2_ENST00000450879.2_Silent_p.P801P|SALL2_ENST00000538754.1_Intron|SALL2_ENST00000317492.5_Intron	NM_005407.1	NP_005398.1	Q9Y467	SALL2_HUMAN	spalt-like transcription factor 2	938							DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|lung(12)|ovary(2)|skin(6)|urinary_tract(2)	43	all_cancers(95;0.000662)			GBM - Glioblastoma multiforme(265;0.0151)		AAGTGAAGAGCGGCCCCTCCT	0.607000													23	46					0	0	1	0	0
LDB2	9079	broad.mit.edu	37	4	16590360	16590360	+	Silent	SNP	T	T	C			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr4:16590360T>C	ENST00000502640.1	-	4	652	c.504A>G	c.(502-504)ttA>ttG	p.L168L	LDB2_ENST00000304523.5_Silent_p.L168L|LDB2_ENST00000503829.1_5'UTR|LDB2_ENST00000515064.1_Silent_p.L168L|LDB2_ENST00000503178.2_Silent_p.L44L|LDB2_ENST00000441778.2_Silent_p.L168L			O43679	LDB2_HUMAN	LIM domain binding 2	168							LIM domain binding|transcription cofactor activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(23)|urinary_tract(1)	33						TTCTCGGGACTAACTCTCGGT	0.393000													32	26					0	0	1	0	0
BBX	56987	broad.mit.edu	37	3	107447670	107447670	+	Missense_Mutation	SNP	A	A	G			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr3:107447670A>G	ENST00000415149.2	+	6	791	c.464A>G	c.(463-465)aAg>aGg	p.K155R	BBX_ENST00000416476.2_Missense_Mutation_p.K155R|BBX_ENST00000406780.1_Missense_Mutation_p.K155R|BBX_ENST00000402543.1_Missense_Mutation_p.K155R|BBX_ENST00000325805.8_Missense_Mutation_p.K155R	NM_001142568.1|NM_020235.5	NP_001136040.1|NP_064620.2	Q8WY36	BBX_HUMAN	bobby sox homolog (Drosophila)	155					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(18)|ovary(4)|pancreas(1)|skin(2)	49			OV - Ovarian serous cystadenocarcinoma(3;0.112)			ACCACAAACAAGCCTGTGAAA	0.408000													110	172					0	0	1	0	0
BAI1	575	broad.mit.edu	37	8	143603386	143603386	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr8:143603386G>A	ENST00000517894.1	+	21	3979	c.3085G>A	c.(3085-3087)Gtg>Atg	p.V1029M	BAI1_ENST00000323289.5_Missense_Mutation_p.V1029M			O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	1029					axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(2)|lung(28)|ovary(4)|pancreas(1)|prostate(7)	57	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					CTTCTGCTGGGTGCTCACCGA	0.692000													17	37					0	0	1	0	0
GIMAP6	474344	broad.mit.edu	37	7	150325213	150325213	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr7:150325213G>T	ENST00000328902.5	-	3	689	c.473C>A	c.(472-474)aCc>aAc	p.T158N	GIMAP6_ENST00000493969.1_3'UTR	NM_001244072.1|NM_024711.5	NP_001231001.1|NP_078987.3	Q6P9H5	GIMA6_HUMAN	GTPase, IMAP family member 6	158							GTP binding			endometrium(4)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	29			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CACCAGGATGGTGTGACCCAG	0.622000													49	42					1.38658e-30	1.58118e-30	1	1	0
BDP1	55814	broad.mit.edu	37	5	70786870	70786870	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr5:70786870C>G	ENST00000358731.4	+	11	1815	c.1552C>G	c.(1552-1554)Ctt>Gtt	p.L518V	BDP1_ENST00000380675.2_5'UTR	NM_018429.2	NP_060899.2	A6H8Y1	BDP1_HUMAN	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB	518					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			NS(2)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(34)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	72		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		GGAGCAGATGCTTTCCTGCAC	0.388000													31	50					0	0	1	0	0
OR9Q1	219956	broad.mit.edu	37	11	57946938	57946938	+	Missense_Mutation	SNP	T	T	G			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr11:57946938T>G	ENST00000335397.3	+	3	338	c.22T>G	c.(22-24)Ttg>Gtg	p.L8V		NM_001005212.3	NP_001005212.1	Q8NGQ5	OR9Q1_HUMAN	olfactory receptor, family 9, subfamily Q, member 1	8					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|liver(1)|lung(12)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26		Breast(21;0.222)				GAACCTCACCTTGGTGACCGA	0.438000													36	71					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176734863	176734863	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr1:176734863G>A	ENST00000367662.3	+	15	5377	c.4213G>A	c.(4213-4215)Gat>Aat	p.D1405N		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1405	Sushi 1.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						TGATCATGCTGATGTGGTGAA	0.507000													45	94					0	0	1	0	0
IL12RB2	3595	broad.mit.edu	37	1	67792498	67792498	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr1:67792498C>T	ENST00000262345.1	+	4	1085	c.445C>T	c.(445-447)Cga>Tga	p.R149*	IL12RB2_ENST00000541374.1_Nonsense_Mutation_p.R149*|IL12RB2_ENST00000544434.1_Nonsense_Mutation_p.R149*|IL12RB2_ENST00000371000.1_Nonsense_Mutation_p.R149*	NM_001559.2	NP_001550.1	Q99665	I12R2_HUMAN	interleukin 12 receptor, beta 2	149	Fibronectin type-III 1.		R -> Q (in dbSNP:rs17129792).		positive regulation of cell proliferation|positive regulation of interferon-gamma production	integral to plasma membrane	cytokine receptor activity			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(8)|lung(21)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	45						GGAAAGAGGACGAGACACCCA	0.408000													15	50					0	0	1	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121679547	121679547	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr7:121679547G>C	ENST00000393386.2	+	20	5953	c.5542G>C	c.(5542-5544)Gag>Cag	p.E1848Q	PTPRZ1_ENST00000449182.1_Missense_Mutation_p.E981Q	NM_001206838.1|NM_002851.2	NP_001193767.1|NP_002842.2	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	1848	Tyrosine-protein phosphatase 1.				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(12)|large_intestine(17)|liver(1)|lung(42)|ovary(4)|prostate(5)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	106						TGGGAGTGAGGAGTACGGGAA	0.393000													14	15					0	0	1	0	0
AZIN1	51582	broad.mit.edu	37	8	103842123	103842123	+	Missense_Mutation	SNP	T	T	C			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr8:103842123T>C	ENST00000337198.5	-	10	2109	c.946A>G	c.(946-948)Atg>Gtg	p.M316V	AZIN1_ENST00000347770.4_Missense_Mutation_p.M316V	NM_148174.2	NP_680479.1	O14977	AZIN1_HUMAN	antizyme inhibitor 1	316					polyamine biosynthetic process|regulation of cellular amino acid metabolic process	cytosol	catalytic activity|protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|prostate(1)|skin(1)|stomach(1)	9	Lung NSC(17;0.000143)|all_lung(17;0.000294)		OV - Ovarian serous cystadenocarcinoma(57;0.000196)|STAD - Stomach adenocarcinoma(118;0.0414)			CCATCATTCATATAATACATG	0.333000													34	94					0	0	1	0	0
LRRK2	120892	broad.mit.edu	37	12	40734100	40734100	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr12:40734100C>G	ENST00000298910.7	+	41	6011	c.5953C>G	c.(5953-5955)Ctc>Gtc	p.L1985V		NM_198578.3	NP_940980.3	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	1985	Protein kinase.				activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding	p.L1985F(1)|p.L1992F(1)		NS(3)|biliary_tract(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(23)|large_intestine(31)|lung(55)|ovary(15)|pancreas(2)|prostate(4)|skin(4)|stomach(9)|upper_aerodigestive_tract(7)|urinary_tract(2)	181	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				TGGCAGATACCTCCACTCAGC	0.368000													58	114					0	0	1	0	0
IFI44	10561	broad.mit.edu	37	1	79120767	79120767	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr1:79120767G>A	ENST00000370747.4	+	4	648	c.563G>A	c.(562-564)cGa>cAa	p.R188Q	IFI44_ENST00000495254.1_3'UTR|IFI44_ENST00000545124.1_5'UTR	NM_006417.4	NP_006408.3	Q8TCB0	IFI44_HUMAN	interferon-induced protein 44	188					response to virus	cytoplasm		p.R188Q(1)		central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(4)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	21						CAACAAATACGAATTCTGCTG	0.463000													23	39					0	0	1	0	0
MROH5	389690	broad.mit.edu	37	8	142517313	142517313	+	RNA	SNP	G	G	A			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr8:142517313G>A	ENST00000430863.1	-	0	17					NM_207414.2	NP_997297.2			maestro heat-like repeat family member 5																		CCTGTGGGCCGGCCCTGTCTA	0.622000													9	31					0	0	1	0	0
DNHD1	144132	broad.mit.edu	37	11	6520037	6520037	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr11:6520037G>A	ENST00000254579.6	+	3	1156	c.592G>A	c.(592-594)Ggc>Agc	p.G198S	DNHD1_ENST00000527990.2_Missense_Mutation_p.G198S|DNHD1_ENST00000354685.3_Missense_Mutation_p.G198S	NM_144666.2	NP_653267.2	Q96M86	DNHD1_HUMAN	dynein heavy chain domain 1	198					microtubule-based movement	dynein complex	microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(4)|endometrium(13)|kidney(6)|large_intestine(11)|lung(14)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	55		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.171)		Epithelial(150;3.93e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		GCGCTGCCTGGGCATTGTTGG	0.592000													61	102					0	0	1	0	0
COL6A6	131873	broad.mit.edu	37	3	130285695	130285695	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr3:130285695G>A	ENST00000358511.6	+	4	1463	c.1432G>A	c.(1432-1434)Gtt>Att	p.V478I	COL6A6_ENST00000453409.2_Missense_Mutation_p.V478I	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	478	Nonhelical region.|VWFA 3.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						GGTTGGGGCCGTTCAGTATGC	0.498000													4	162					0	0	1	0	0
PAFAH1B2	5049	broad.mit.edu	37	11	117038340	117038340	+	Silent	SNP	C	C	T			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr11:117038340C>T	ENST00000527958.1	+	6	774	c.615C>T	c.(613-615)atC>atT	p.I205I	PAFAH1B2_ENST00000526888.1_Intron|PAFAH1B2_ENST00000419197.2_Intron|PAFAH1B2_ENST00000529887.2_Intron|PAFAH1B2_ENST00000530272.1_Intron	NM_002572.3	NP_002563.1	P68402	PA1B2_HUMAN	platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)	205					lipid catabolic process	cytoplasm	1-alkyl-2-acetylglycerophosphocholine esterase activity			kidney(1)	1	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;1.68e-05)|Epithelial(105;0.000162)|all cancers(92;0.00111)		ATGCAAAGATCTGCAAACCCC	0.502000			T	IGH@	MLCLS								5	23					0	0	1	0	0
TNPO2	30000	broad.mit.edu	37	19	12821510	12821510	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr19:12821510G>A	ENST00000425528.1	-	13	1552	c.1195C>T	c.(1195-1197)Ctc>Ttc	p.L399F	TNPO2_ENST00000450764.2_Missense_Mutation_p.L399F|TNPO2_ENST00000441499.1_Missense_Mutation_p.L399F|TNPO2_ENST00000588216.1_Missense_Mutation_p.L399F|TNPO2_ENST00000592287.1_Missense_Mutation_p.L399F|TNPO2_ENST00000356861.5_Missense_Mutation_p.L399F			O14787	TNPO2_HUMAN	transportin 2	399				LLKG -> YQS (in Ref. 1; AAB83973).	intracellular protein transport	cytoplasm|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(2)|large_intestine(2)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						AGGCCTTTGAGTAGTGGGAGT	0.637000													11	18					0	0	1	0	0
PLA2R1	22925	broad.mit.edu	37	2	160826660	160826660	+	Splice_Site	SNP	G	G	A	rs113304621	byFrequency	TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr2:160826660G>A	ENST00000283243.7	-	18	2865	c.2660_splice	c.e18+1	p.R887_splice	PLA2R1_ENST00000392771.1_Splice_Site_p.R887_splice	NM_001195641.1|NM_007366.4	NP_001182570.1|NP_031392.3	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1, 180kDa	887	C-type lectin 5.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding	p.R887C(1)	PLA2R1/RBMS1(2)	central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(17)|lung(20)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	60						GGTTCATACCGAAATTCATCA	0.318000													10	31					0	0	1	0	0
ZSCAN10	84891	broad.mit.edu	37	16	3140535	3140535	+	Silent	SNP	C	C	T			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr16:3140535C>T	ENST00000252463.2	-	5	822	c.735G>A	c.(733-735)ccG>ccA	p.P245P	ZSCAN10_ENST00000538082.2_Silent_p.P163P|ZSCAN10_ENST00000575108.1_5'UTR	NM_032805.1	NP_116194.1	Q96SZ4	ZSC10_HUMAN	zinc finger and SCAN domain containing 10	245					negative regulation of transcription, DNA-dependent|viral reproduction	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(3)|endometrium(3)|kidney(1)|lung(8)|ovary(2)|prostate(1)|skin(4)|urinary_tract(1)	24						AAGGCTCTCCCGGCACCCCAG	0.602000													42	87					0	0	1	0	0
TRAF3IP3	80342	broad.mit.edu	37	1	209933614	209933614	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr1:209933614G>A	ENST00000367024.1	+	3	746	c.230G>A	c.(229-231)gGc>gAc	p.G77D	TRAF3IP3_ENST00000010338.4_Missense_Mutation_p.G77D|TRAF3IP3_ENST00000367025.3_Missense_Mutation_p.G77D|TRAF3IP3_ENST00000367026.3_Missense_Mutation_p.G77D|TRAF3IP3_ENST00000400959.3_Missense_Mutation_p.G77D			Q9Y228	T3JAM_HUMAN	TRAF3 interacting protein 3	77						integral to membrane	protein binding			breast(2)|endometrium(1)|large_intestine(8)|lung(15)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32				OV - Ovarian serous cystadenocarcinoma(81;0.045)		GAGGAGAAGGGCAAAGCGCAG	0.597000													3	38					0	0	1	0	0
SENP3-EIF4A1	100533955	broad.mit.edu	37	17	7476054	7476054	+	RNA	SNP	C	C	T			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr17:7476054C>T	ENST00000579777.1	+	0	1965					NR_037926.1																						TTGCTGAGCGCCGGCAGGCGG	0.647000													10	21					0	0	1	0	0
WWC2	80014	broad.mit.edu	37	4	184166648	184166648	+	Missense_Mutation	SNP	A	A	G			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr4:184166648A>G	ENST00000403733.3	+	6	881	c.682A>G	c.(682-684)Atc>Gtc	p.I228V	WWC2_ENST00000504005.1_Intron|WWC2_ENST00000513834.1_Missense_Mutation_p.I228V|WWC2_ENST00000448232.2_Missense_Mutation_p.I228V|WWC2_ENST00000378925.3_Missense_Mutation_p.I130V	NM_024949.5	NP_079225.5	Q6AWC2	WWC2_HUMAN	WW and C2 domain containing 2	228										NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(15)|ovary(2)|prostate(1)|stomach(1)|urinary_tract(3)	32		all_lung(41;5.28e-14)|Lung NSC(41;1.35e-13)|Colorectal(36;0.00681)|Hepatocellular(41;0.00886)|Renal(120;0.00992)|Prostate(90;0.0237)|all_hematologic(60;0.0592)|Esophageal squamous(56;0.179)|all_neural(102;0.202)		all cancers(43;3.38e-24)|Epithelial(43;1.4e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.09e-09)|GBM - Glioblastoma multiforme(59;3.33e-05)|Colorectal(24;3.58e-05)|STAD - Stomach adenocarcinoma(60;4.21e-05)|COAD - Colon adenocarcinoma(29;0.000171)|LUSC - Lung squamous cell carcinoma(40;0.0145)|READ - Rectum adenocarcinoma(43;0.242)		ACTAAAATCTATCAGAAAGGC	0.373000													7	10					0	0	1	0	0
MYT1L	23040	broad.mit.edu	37	2	1926541	1926541	+	Missense_Mutation	SNP	A	A	C			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr2:1926541A>C	ENST00000399161.2	-	10	1747	c.1000T>G	c.(1000-1002)Tgc>Ggc	p.C334G	MYT1L_ENST00000428368.2_Missense_Mutation_p.C334G	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	334					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		AGGTCGAAGCACTGATTCCTC	0.547000													25	43					0	0	1	0	0
TMPRSS15	5651	broad.mit.edu	37	21	19666724	19666724	+	Silent	SNP	T	T	C			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr21:19666724T>C	ENST00000284885.3	-	21	2382	c.2349A>G	c.(2347-2349)ccA>ccG	p.P783P		NM_002772.2	NP_002763.2	P98073	ENTK_HUMAN	transmembrane protease, serine 15	783					proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			NS(1)|breast(2)|cervix(1)|endometrium(4)|kidney(7)|large_intestine(19)|lung(36)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	85						CAACAATCTTTGGGGTGATGT	0.463000													67	132					0	0	1	0	0
ACSM1	116285	broad.mit.edu	37	16	20693611	20693611	+	Translation_Start_Site	SNP	C	C	T	rs146861278	byFrequency	TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr16:20693611C>T	ENST00000219151.4	-	0	645				ACSM1_ENST00000520010.1_Missense_Mutation_p.R193H|ACSM1_ENST00000307493.4_Missense_Mutation_p.R193H			Q08AH1	ACSM1_HUMAN	acyl-CoA synthetase medium-chain family member 1						benzoate metabolic process|butyrate metabolic process|energy derivation by oxidation of organic compounds|fatty acid oxidation|xenobiotic metabolic process	mitochondrial matrix	acyl-CoA ligase activity|ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(23)|skin(3)|upper_aerodigestive_tract(2)	42						CCACCCTTCACGGCTGTGATC	0.493000													16	47					0	0	1	0	0
ELTD1	64123	broad.mit.edu	37	1	79392614	79392614	+	Missense_Mutation	SNP	A	A	G			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr1:79392614A>G	ENST00000370742.3	-	8	1103	c.1040T>C	c.(1039-1041)tTa>tCa	p.L347S		NM_022159.3	NP_071442.2	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain containing 1	347					neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(45)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	69				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		AAGTTCATATAATGTGGGTGG	0.333000													18	38					0	0	1	0	0
ZXDC	79364	broad.mit.edu	37	3	126180392	126180392	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr3:126180392C>T	ENST00000389709.3	-	6	2166	c.2113G>A	c.(2113-2115)Ggc>Agc	p.G705S	ZXDC_ENST00000336332.5_Missense_Mutation_p.G705S	NM_025112.4	NP_079388.3	Q2QGD7	ZXDC_HUMAN	ZXD family zinc finger C	705					positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|LRR domain binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(9)|ovary(1)	17				GBM - Glioblastoma multiforme(114;0.155)		TAGAAGTTGCCAGTGCCTGCA	0.517000													15	30					0	0	1	0	0
OR5AS1	219447	broad.mit.edu	37	11	55798044	55798044	+	Missense_Mutation	SNP	T	T	A			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr11:55798044T>A	ENST00000313555.1	+	1	150	c.150T>A	c.(148-150)aaT>aaA	p.N50K		NM_001001921.1	NP_001001921.1	Q8N127	O5AS1_HUMAN	olfactory receptor, family 5, subfamily AS, member 1	50					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(7)|large_intestine(7)|liver(1)|lung(22)|ovary(3)|prostate(4)|skin(3)|stomach(1)	48	Esophageal squamous(21;0.00693)					TTCTAGTTAATATTAATTCAA	0.333000													10	23					0	0	1	0	0
FNBP4	23360	broad.mit.edu	37	11	47753078	47753078	+	Nonsense_Mutation	SNP	G	G	T			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr11:47753078G>T	ENST00000263773.5	-	12	1868	c.1856C>A	c.(1855-1857)tCg>tAg	p.S619*		NM_015308.2	NP_056123.2	Q8N3X1	FNBP4_HUMAN	formin binding protein 4	619	WW 2.									NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(12)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	44						AGACTCGCCCGACTGTTCGTT	0.408000													40	78					3.38236e-24	3.82353e-24	1	1	0
OR2H1	26716	broad.mit.edu	37	6	29429615	29429615	+	Silent	SNP	G	G	A			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr6:29429615G>A	ENST00000377136.1	+	4	534	c.69G>A	c.(67-69)agG>agA	p.R23R	OR2H1_ENST00000473369.1_Intron|OR2H1_ENST00000442615.1_Silent_p.R23R|OR2H1_ENST00000377133.1_Silent_p.R23R|OR2H1_ENST00000377132.1_Silent_p.R23R|OR2H1_ENST00000396792.2_Silent_p.R23R			Q9GZK4	OR2H1_HUMAN	olfactory receptor, family 2, subfamily H, member 1	23					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(5)|lung(12)	17						CACTGGAAAGGACTCTCTTTG	0.532000													47	102					0	0	1	0	0
USP17L2	377630	broad.mit.edu	37	8	11995582	11995582	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr8:11995582C>A	ENST00000333796.3	-	1	1004	c.688G>T	c.(688-690)Gct>Tct	p.A230S	FAM66D_ENST00000434078.2_RNA	NM_001256869.1|NM_001256871.1|NM_001256872.1|NM_001256873.1|NM_001256874.1|NM_201402.2	NP_001243798.1|NP_001243800.1|NP_001243801.1|NP_001243802.1|NP_001243803.1|NP_958804.2	Q6R6M4	U17L2_HUMAN	ubiquitin specific peptidase 17-like family member 2	230					apoptosis|cell cycle|G2/M transition checkpoint|mitotic cell cycle G1/S transition checkpoint|protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			central_nervous_system(1)|kidney(1)|large_intestine(11)|liver(1)|lung(8)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	29						ACACTCTGAGCTGCCTGGATA	0.522000													17	51					2.35188e-11	2.59106e-11	1	1	0
RNF214	257160	broad.mit.edu	37	11	117117602	117117602	+	Silent	SNP	G	G	A			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr11:117117602G>A	ENST00000530849.1	+	5	442	c.432G>A	c.(430-432)gaG>gaA	p.E144E	RNF214_ENST00000531452.1_Silent_p.E299E|RNF214_ENST00000300650.4_Silent_p.E299E|RNF214_ENST00000531287.1_Silent_p.E144E			Q8ND24	RN214_HUMAN	ring finger protein 214	299							zinc ion binding			cervix(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	23	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.88e-05)|Epithelial(105;0.000397)|all cancers(92;0.00258)		AGAAGAAGGAGTTTTTGCAGA	0.388000													43	82					0	0	1	0	0
CAMK2D	817	broad.mit.edu	37	4	114436283	114436283	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr4:114436283G>C	ENST00000454265.2	-	10	1619	c.761C>G	c.(760-762)aCt>aGt	p.T254S	CAMK2D_ENST00000429180.1_Missense_Mutation_p.T254S|CAMK2D_ENST00000394526.2_Missense_Mutation_p.T254S|CAMK2D_ENST00000342666.5_Missense_Mutation_p.T254S|CAMK2D_ENST00000394522.3_Missense_Mutation_p.T254S|CAMK2D_ENST00000508738.1_Missense_Mutation_p.T254S|CAMK2D_ENST00000418639.2_Missense_Mutation_p.T254S|CAMK2D_ENST00000511664.1_Missense_Mutation_p.T254S|CAMK2D_ENST00000515496.1_Missense_Mutation_p.T254S|CAMK2D_ENST00000505990.1_Missense_Mutation_p.T254S|CAMK2D_ENST00000379773.2_Missense_Mutation_p.T254S|CAMK2D_ENST00000296402.5_Missense_Mutation_p.T254S|CAMK2D_ENST00000394524.3_Missense_Mutation_p.T254S|CAMK2D_ENST00000514328.1_Missense_Mutation_p.T254S			Q13557	KCC2D_HUMAN	calcium/calmodulin-dependent protein kinase II delta	254	Protein kinase.				interferon-gamma-mediated signaling pathway|regulation of cell growth|synaptic transmission	calcium- and calmodulin-dependent protein kinase complex|cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)	13		Ovarian(17;0.00369)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000271)		AGGGTTGATAGTAAGCATTTT	0.368000													28	123					0	0	1	0	0
RBM43	375287	broad.mit.edu	37	2	152107874	152107874	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr2:152107874C>T	ENST00000331426.5	-	4	771	c.620G>A	c.(619-621)aGg>aAg	p.R207K		NM_198557.2	NP_940959.1	Q6ZSC3	RBM43_HUMAN	RNA binding motif protein 43	207							nucleotide binding|RNA binding			endometrium(2)|large_intestine(3)|lung(2)|ovary(1)	8				BRCA - Breast invasive adenocarcinoma(221;0.131)		TACTAAGGTCCTGACTGATGC	0.393000													23	40					0	0	1	0	0
PUM1	9698	broad.mit.edu	37	1	31454214	31454214	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr1:31454214C>G	ENST00000373747.3	-	8	1296	c.1197G>C	c.(1195-1197)ttG>ttC	p.L399F	PUM1_ENST00000440538.2_Missense_Mutation_p.L399F|PUM1_ENST00000426105.2_Missense_Mutation_p.L399F|PUM1_ENST00000423018.2_Missense_Mutation_p.L303F|PUM1_ENST00000257075.5_Missense_Mutation_p.L399F|PUM1_ENST00000424085.2_Missense_Mutation_p.L157F|PUM1_ENST00000373742.2_Missense_Mutation_p.L339F|PUM1_ENST00000373741.4_Missense_Mutation_p.L435F	NM_001020658.1	NP_001018494.1	Q14671	PUM1_HUMAN	pumilio RNA-binding family member 1	399	Ala-rich.				cellular membrane organization|post-Golgi vesicle-mediated transport|regulation of translation	cytosol	RNA binding			breast(1)|central_nervous_system(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(17)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	48		Colorectal(325;0.0211)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0381)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0232)|READ - Rectum adenocarcinoma(331;0.0681)		GAGCAGCTGTCAACTGCTGGA	0.498000													19	31					0	0	1	0	0
LILRP2	79166	broad.mit.edu	37	19	55222088	55222088	+	RNA	SNP	T	T	A			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr19:55222088T>A	ENST00000413439.1	+	0	1615																											CCATGAGTCCTGTGACCTCAG	0.602000													8	21					0	0	1	0	0
HIVEP3	59269	broad.mit.edu	37	1	42047649	42047649	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr1:42047649C>A	ENST00000372584.1	-	3	3834	c.2820G>T	c.(2818-2820)ttG>ttT	p.L940F	HIVEP3_ENST00000429157.2_Missense_Mutation_p.L940F|HIVEP3_ENST00000372583.1_Missense_Mutation_p.L940F|HIVEP3_ENST00000247584.5_Missense_Mutation_p.L940F	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	940	No DNA binding activity or transactivation activity, but complete prevention of TRAF-dependent NF-Kappa-B activation; associates with TRAF2 and JUN (By similarity).|Ser-rich.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				TGGACCCACTCAAAGAGACAT	0.622000													13	198					3.27435e-08	3.4607e-08	1	1	0
FRG1BP	284802	broad.mit.edu	37	20	29625934	29625934	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr20:29625934C>T	ENST00000278882.3	+	5	558	c.178C>T	c.(178-180)Cat>Tat	p.H60Y	FRG1B_ENST00000358464.4_Missense_Mutation_p.H60Y|FRG1B_ENST00000439954.2_Missense_Mutation_p.H65Y																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ACTTGTTGGGCATTCAGATGC	0.338000													5	124					0	0	1	0	0
CAPRIN2	65981	broad.mit.edu	37	12	30881830	30881830	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr12:30881830G>A	ENST00000251071.5	-	8	2284	c.1534C>T	c.(1534-1536)Cca>Tca	p.P512S	CAPRIN2_ENST00000308433.5_Missense_Mutation_p.P179S|CAPRIN2_ENST00000417045.1_Missense_Mutation_p.P512S|CAPRIN2_ENST00000298892.5_Missense_Mutation_p.P512S|CAPRIN2_ENST00000395805.2_Missense_Mutation_p.P512S|CAPRIN2_ENST00000538387.1_5'UTR	NM_001002259.1|NM_032156.3	NP_001002259.1|NP_115532.3	Q6IMN6	CAPR2_HUMAN	caprin family member 2	512					negative regulation of cell growth|negative regulation of translation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of transcription from RNA polymerase II promoter	mitochondrion|receptor complex	receptor binding|RNA binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(4)|large_intestine(13)|lung(16)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	48	all_lung(12;1.13e-09)|Lung NSC(12;7.98e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					CAAGACTTTGGAGTTTGCTTC	0.473000													39	56					0	0	1	0	0
SRCAP	10847	broad.mit.edu	37	16	30744978	30744978	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr16:30744978C>T	ENST00000262518.4	+	29	6738	c.6353C>T	c.(6352-6354)aCt>aTt	p.T2118I	SRCAP_ENST00000395059.2_Missense_Mutation_p.T2056I|SRCAP_ENST00000344771.4_Missense_Mutation_p.T1960I	NM_006662.2	NP_006653.2	Q6ZRS2	SRCAP_HUMAN	Snf2-related CREBBP activator protein	2118	Helicase C-terminal.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			ATCCTTTCAACTCGGAGTGGG	0.507000													40	71					0	0	1	0	0
AIF1L	83543	broad.mit.edu	37	9	133987042	133987042	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr9:133987042C>G	ENST00000372309.3	+	4	384	c.230C>G	c.(229-231)gCc>gGc	p.A77G	AIF1L_ENST00000372300.1_Missense_Mutation_p.A51G|AIF1L_ENST00000372297.2_5'UTR|AIF1L_ENST00000247291.3_Missense_Mutation_p.A51G|AIF1L_ENST00000372302.1_Missense_Mutation_p.A51G|AIF1L_ENST00000372301.2_5'UTR|AIF1L_ENST00000472942.1_3'UTR|AIF1L_ENST00000372312.3_Missense_Mutation_p.A56G|AIF1L_ENST00000372298.1_Missense_Mutation_p.A51G	NM_001185095.1	NP_001172024.1	Q9BQI0	AIF1L_HUMAN	allograft inflammatory factor 1-like	51	EF-hand 1.					actin cytoskeleton|cytoplasm|focal adhesion|ruffle membrane	actin filament binding|calcium ion binding			lung(2)	2						AAGCTCACAGCCTTCAAAGGT	0.567000													14	234					0	0	1	0	0
TMEM39A	55254	broad.mit.edu	37	3	119156860	119156860	+	Silent	SNP	C	C	T			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr3:119156860C>T	ENST00000319172.5	-	6	1086	c.666G>A	c.(664-666)gaG>gaA	p.E222E	TMEM39A_ENST00000486159.1_5'UTR	NM_018266.1	NP_060736.1	Q9NV64	TM39A_HUMAN	transmembrane protein 39A	222						integral to membrane				NS(1)|breast(1)|endometrium(1)|large_intestine(2)|lung(5)|ovary(2)|skin(1)	13				GBM - Glioblastoma multiforme(114;0.244)		CCTCTACTGCCTCGTGCTGAA	0.433000													15	28					0	0	1	0	0
SIK3	23387	broad.mit.edu	37	11	116746969	116746969	+	Splice_Site	SNP	C	C	T			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr11:116746969C>T	ENST00000375300.1	-	8	1100	c.1095_splice	c.e8+1	p.Q365_splice	SIK3_ENST00000434315.2_Splice_Site_p.Q206_splice|SIK3_ENST00000446921.2_Splice_Site_p.Q365_splice|SIK3_ENST00000542607.1_Splice_Site_p.Q307_splice|SIK3_ENST00000292055.4_Splice_Site_p.Q307_splice|SIK3_ENST00000375288.1_5'UTR			Q9Y2K2	SIK3_HUMAN	SIK family kinase 3	307						cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			breast(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(18)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	57						TCGGAGATACCTGCAGTGTCT	0.483000													29	52					0	0	1	0	0
SLCO2A1	6578	broad.mit.edu	37	3	133698375	133698375	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr3:133698375G>A	ENST00000310926.4	-	2	457	c.184C>T	c.(184-186)Cgc>Tgc	p.R62C	SLCO2A1_ENST00000493729.1_Missense_Mutation_p.R62C|SLCO2A1_ENST00000478651.1_5'UTR	NM_005630.2	NP_005621.2	Q92959	SO2A1_HUMAN	solute carrier organic anion transporter family, member 2A1	62					sodium-independent organic anion transport	integral to plasma membrane|membrane fraction	prostaglandin transmembrane transporter activity|protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|skin(2)|stomach(2)	30						AGCCCAAAGCGCTTCTCAATG	0.557000													13	138					0	0	1	0	0
SMARCAD1	56916	broad.mit.edu	37	4	95174149	95174149	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr4:95174149G>C	ENST00000354268.4	+	9	1345	c.1272G>C	c.(1270-1272)tgG>tgC	p.W424C	SMARCAD1_ENST00000457823.2_Missense_Mutation_p.W424C			Q9H4L7	SMRCD_HUMAN	SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1	424					chromatin modification|nucleotide metabolic process|positive regulation of transcription, DNA-dependent|protein homooligomerization|regulation of DNA recombination	nuclear matrix	ATP binding|DNA binding|helicase activity			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(11)|liver(2)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	44				OV - Ovarian serous cystadenocarcinoma(123;4.33e-08)		TTAATAGTTGGGAGGCTCTGG	0.408000													112	33					0	0	1	0	0
EEF1G	1937	broad.mit.edu	37	11	62334423	62334423	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr11:62334423G>A	ENST00000378019.3	-	7	952	c.862C>T	c.(862-864)Cgg>Tgg	p.R288W	MIR3654_ENST00000496634.2_3'UTR|EEF1G_ENST00000329251.4_Missense_Mutation_p.R238W			P26641	EF1G_HUMAN	eukaryotic translation elongation factor 1 gamma	238	EF-1-gamma C-terminal.				response to virus	cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity			breast(2)|endometrium(4)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						TTCTCTTCCCGTGAACCCTTC	0.552000													4	187					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168099555	168099555	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr2:168099555C>A	ENST00000409195.1	+	9	1742	c.1653C>A	c.(1651-1653)gaC>gaA	p.D551E	XIRP2_ENST00000295237.9_Missense_Mutation_p.D551E|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409273.1_Missense_Mutation_p.D329E|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409605.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	376					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						ACACAAATGACAGTTCTCAAA	0.398000													9	13					2.17888e-05	2.23035e-05	1	1	0
CTTNBP2	83992	broad.mit.edu	37	7	117407215	117407215	+	Silent	SNP	A	A	G			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr7:117407215A>G	ENST00000160373.3	-	9	2885	c.2794T>C	c.(2794-2796)Ttg>Ctg	p.L932L		NM_033427.2	NP_219499.1	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	932										breast(3)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(36)|ovary(4)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		TGCCTACACAAGATTTCTAGG	0.438000													27	15					0	0	1	0	0
OR1M1	125963	broad.mit.edu	37	19	9204125	9204125	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr19:9204125G>A	ENST00000429566.3	+	1	271	c.205G>A	c.(205-207)Gtt>Att	p.V69I		NM_001004456.1	NP_001004456.1	Q8NGA1	OR1M1_HUMAN	olfactory receptor, family 1, subfamily M, member 1	69					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.V69I(2)		breast(1)|endometrium(4)|large_intestine(3)|lung(17)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	32						CCTGTCCCTGGTTGATTTCTG	0.557000													4	85					0	0	1	0	0
GRIK5	2901	broad.mit.edu	37	19	42510913	42510913	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr19:42510913C>T	ENST00000262895.3	-	15	1920	c.1921G>A	c.(1921-1923)Gcc>Acc	p.A641T	GRIK5_ENST00000301218.4_Missense_Mutation_p.A641T|GRIK5_ENST00000593562.1_Missense_Mutation_p.A641T	NM_002088.4	NP_002079.3	Q16478	GRIK5_HUMAN	glutamate receptor, ionotropic, kainate 5	641						cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(11)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	35		Prostate(69;0.059)			L-Glutamic Acid(DB00142)	GTGAGGAAGGCGGCCAGGTTG	0.632000													15	34					0	0	1	0	0
OR4C46	119749	broad.mit.edu	37	11	51515885	51515885	+	Nonsense_Mutation	SNP	G	G	T			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr11:51515885G>T	ENST00000328188.1	+	1	604	c.604G>T	c.(604-606)Gga>Tga	p.G202*		NM_001004703.1	NP_001004703.1	A6NHA9	O4C46_HUMAN	olfactory receptor, family 4, subfamily C, member 46	202					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(5)|large_intestine(5)|lung(31)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	48						TGCCAACAGTGGATTCATCTG	0.483000													33	51					6.04164e-23	6.77081e-23	1	1	0
C1orf159	54991	broad.mit.edu	37	1	1019364	1019364	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr1:1019364G>A	ENST00000448924.1	-	10	1410	c.979C>T	c.(979-981)Ctc>Ttc	p.L327F	C1orf159_ENST00000421241.2_Intron|C1orf159_ENST00000379320.1_Missense_Mutation_p.L291F|C1orf159_ENST00000379319.1_Intron|C1orf159_ENST00000482816.1_5'UTR|C1orf159_ENST00000379339.1_Missense_Mutation_p.L327F|C1orf159_ENST00000294576.5_Missense_Mutation_p.L291F			Q96HA4	CA159_HUMAN	chromosome 1 open reading frame 159	327						integral to membrane						all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;2.96e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.77e-22)|Colorectal(212;6.51e-05)|COAD - Colon adenocarcinoma(227;0.000214)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|Kidney(185;0.00254)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.037)|Lung(427;0.205)		GCCTGGCGGAGGCCGGCTGCG	0.647000													4	8					0	0	1	0	0
VNN1	8876	broad.mit.edu	37	6	133014187	133014187	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr6:133014187G>A	ENST00000367928.4	-	4	815	c.802C>T	c.(802-804)Cat>Tat	p.H268Y		NM_004666.2	NP_004657.2	O95497	VNN1_HUMAN	vanin 1	268	CN hydrolase.				acute inflammatory response|anti-apoptosis|cell-cell adhesion|cellular component movement|chronic inflammatory response|innate immune response|pantothenate metabolic process|positive regulation of T cell differentiation in thymus|response to oxidative stress	anchored to membrane|integral to membrane|plasma membrane	GPI anchor binding|pantetheine hydrolase activity			NS(2)|endometrium(3)|kidney(2)|large_intestine(8)|lung(10)|ovary(4)|prostate(1)|upper_aerodigestive_tract(1)	31	Breast(56;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.0027)|GBM - Glioblastoma multiforme(226;0.0189)		GAGGGGTAATGTATGTTGGAT	0.388000													10	20					0	0	1	0	0
SLC22A2	6582	broad.mit.edu	37	6	160671714	160671714	+	Missense_Mutation	SNP	A	A	G			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr6:160671714A>G	ENST00000366952.1	-	5	1957	c.476T>C	c.(475-477)cTc>cCc	p.L159P	SLC22A2_ENST00000366953.3_Missense_Mutation_p.L180P|SLC22A2_ENST00000491092.1_5'UTR			O15244	S22A2_HUMAN	solute carrier family 22 (organic cation transporter), member 2	180					body fluid secretion|neurotransmitter biosynthetic process|neurotransmitter secretion	integral to plasma membrane|membrane fraction	neurotransmitter transporter activity|organic cation transmembrane transporter activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(16)|prostate(2)|skin(1)	27		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.28e-17)|BRCA - Breast invasive adenocarcinoma(81;6.29e-06)		TGTAGTTAGGAGGCAGAGCTT	0.418000													31	74					0	0	1	0	0
ONECUT3	390874	broad.mit.edu	37	19	1775232	1775232	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr19:1775232C>T	ENST00000382349.4	+	2	2563	c.1273C>T	c.(1273-1275)Cag>Tag	p.Q425*		NM_001080488.1	NP_001073957.1	O60422	ONEC3_HUMAN	one cut homeobox 3	425					endocrine pancreas development		sequence-specific DNA binding						Acute lymphoblastic leukemia(61;4.66e-11)|all_hematologic(61;4.59e-07)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CACCGACCTGCAGCGACGCAC	0.652000													6	11					0	0	1	0	0
PHF3	23469	broad.mit.edu	37	6	64423032	64423032	+	Missense_Mutation	SNP	A	A	T			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr6:64423032A>T	ENST00000262043.3	+	16	5888	c.5548A>T	c.(5548-5550)Aat>Tat	p.N1850Y	PHF3_ENST00000393387.1_Missense_Mutation_p.N1850Y			Q92576	PHF3_HUMAN	PHD finger protein 3	1850	Pro-rich.				multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			breast(7)|cervix(2)|endometrium(8)|kidney(7)|large_intestine(18)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(6)	75	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			CTTTGCTCAAAATCCCATGGT	0.512000													66	107					0	0	1	0	0
BCAP29	55973	broad.mit.edu	37	7	107234468	107234468	+	Translation_Start_Site	SNP	G	G	A			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr7:107234468G>A	ENST00000379121.2	+	0	2				BCAP29_ENST00000379117.2_Missense_Mutation_p.D88N|BCAP29_ENST00000494086.1_3'UTR|BCAP29_ENST00000379119.2_Missense_Mutation_p.D88N|BCAP29_ENST00000465919.1_De_novo_Start_OutOfFrame|BCAP29_ENST00000005259.4_Missense_Mutation_p.D88N|BCAP29_ENST00000445771.2_Missense_Mutation_p.D88N			Q9UHQ4	BAP29_HUMAN	B-cell receptor-associated protein 29						apoptosis|intracellular protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|integral to membrane				cervix(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(2)|skin(1)|urinary_tract(1)	14						CAGCAGACCTGATGCCTATGA	0.343000													100	44					0	0	1	0	0
ATN1	1822	broad.mit.edu	37	12	7046137	7046137	+	Silent	SNP	T	T	A	rs143934146		TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr12:7046137T>A	ENST00000356654.4	+	5	1944	c.1707T>A	c.(1705-1707)tcT>tcA	p.S569S	ATN1_ENST00000396684.2_Silent_p.S569S	NM_001007026.1	NP_001007027.1	P54259	ATN1_HUMAN	atrophin 1	569	Poly-Ser.				cell death|central nervous system development	cytoplasm|nucleus	protein domain specific binding			breast(5)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(15)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	40						CTCCAGTCTCTTCCTCTTCCA	0.632000													40	111					0	0	1	0	0
MAVS	57506	broad.mit.edu	37	20	3845164	3845164	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr20:3845164C>T	ENST00000428216.2	+	6	1015	c.887C>T	c.(886-888)tCc>tTc	p.S296F	MAVS_ENST00000416600.2_Missense_Mutation_p.S155F|MAVS_ENST00000358134.6_3'UTR	NM_020746.4	NP_065797.2	Q7Z434	MAVS_HUMAN	mitochondrial antiviral signaling protein	296					activation of innate immune response|cellular response to exogenous dsRNA|defense response to bacterium|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of chemokine (C-C motif) ligand 5 production|positive regulation of defense response to virus by host|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interleukin-8 production|positive regulation of IP-10 production|positive regulation of protein import into nucleus, translocation|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of type I interferon-mediated signaling pathway|response to virus	integral to membrane|mitochondrial outer membrane	CARD domain binding|protein kinase binding|signal transducer activity			autonomic_ganglia(1)|breast(3)|endometrium(1)|large_intestine(3)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	14						TCTCTGCCCTCCAAAGTGCCT	0.592000													30	50					0	0	1	0	0
NCAN	1463	broad.mit.edu	37	19	19330002	19330002	+	Silent	SNP	C	C	A	rs138463686		TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr19:19330002C>A	ENST00000252575.5	+	3	395	c.352C>A	c.(352-354)Cgg>Agg	p.R118R		NM_004386.2	NP_004377.2	O14594	NCAN_HUMAN	neurocan	118	Ig-like V-type.				axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(32)|ovary(5)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64			Epithelial(12;0.00544)			TTCCTACCCCCGGCGCCGAGC	0.652000													13	20					2.27111e-07	2.381e-07	1	1	0
STAG2	10735	broad.mit.edu	37	X	123195628	123195628	+	Silent	SNP	A	A	G			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chrX:123195628A>G	ENST00000371160.1	+	17	1832	c.1542A>G	c.(1540-1542)acA>acG	p.T514T	STAG2_ENST00000354548.5_Silent_p.T445T|STAG2_ENST00000371157.3_Silent_p.T514T|STAG2_ENST00000371144.3_Silent_p.T514T|STAG2_ENST00000371145.3_Silent_p.T514T|STAG2_ENST00000218089.9_Silent_p.T514T|STAG2_ENST00000469481.1_Intron			Q8N3U4	STAG2_HUMAN	stromal antigen 2	514					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(9)|lung(21)|ovary(5)|prostate(2)|skin(5)|urinary_tract(4)	78						tAGCACTAACAGATAGGCAAG	0.353000													4	4					0	0	1	0	0
TRGC2	6967	broad.mit.edu	37	7	38288848	38288848	+	RNA	SNP	C	C	G			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr7:38288848C>G	ENST00000436911.2	-	0	325																											ACATACCTGTCTTTATTGGAG	0.338000													16	19					0	0	1	0	0
MDC1	9656	broad.mit.edu	37	6	30681696	30681696	+	Missense_Mutation	SNP	T	T	A			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr6:30681696T>A	ENST00000376406.3	-	3	1048	c.401A>T	c.(400-402)gAt>gTt	p.D134V	MDC1_ENST00000376405.2_Missense_Mutation_p.D134V	NM_014641.2	NP_055456.2	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	134	Interaction with CHEK2.|Interaction with the MRN complex.				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|kidney(1)|ovary(1)	4						CAGAGAGACATCCAGGCGATG	0.557000								Other conserved DNA damage response genes					21	66					0	0	1	0	0
ESAM	90952	broad.mit.edu	37	11	124624558	124624558	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr11:124624558C>T	ENST00000278927.5	-	5	838	c.709G>A	c.(709-711)Gtg>Atg	p.V237M	ESAM_ENST00000442070.2_Missense_Mutation_p.V58M	NM_138961.2	NP_620411.2	Q96AP7	ESAM_HUMAN	endothelial cell adhesion molecule	237	Ig-like C2-type.				blood coagulation|leukocyte migration	adherens junction|integral to membrane|tight junction				endometrium(2)|kidney(1)|large_intestine(6)|lung(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	16	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.022)		TCCAGCGTCACATTACATTGG	0.552000													61	112					0	0	1	0	0
EPHA4	2043	broad.mit.edu	37	2	222294710	222294710	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr2:222294710G>C	ENST00000281821.2	-	15	2699	c.2658C>G	c.(2656-2658)aaC>aaG	p.N886K	EPHA4_ENST00000392071.4_Missense_Mutation_p.N835K|EPHA4_ENST00000409938.1_Missense_Mutation_p.N886K|EPHA4_ENST00000409854.1_Missense_Mutation_p.N886K	NM_004438.3	NP_004429.1	P54764	EPHA4_HUMAN	EPH receptor A4	886						integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(21)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Renal(207;0.0183)		Epithelial(121;5.38e-09)|all cancers(144;2.47e-06)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(261;0.0154)		TCTTCAAGCTGTTGGGGTTGC	0.507000													5	166					0	0	1	0	0
ZFYVE9	9372	broad.mit.edu	37	1	52698894	52698894	+	Missense_Mutation	SNP	C	C	G	rs145555218		TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr1:52698894C>G	ENST00000287727.3	+	3	188	c.16C>G	c.(16-18)Caa>Gaa	p.Q6E	ZFYVE9_ENST00000361625.1_Missense_Mutation_p.Q6E|ZFYVE9_ENST00000357206.2_Missense_Mutation_p.Q6E|ZFYVE9_ENST00000371591.1_Missense_Mutation_p.Q6E	NM_004799.2	NP_004790.2	O95405	ZFYV9_HUMAN	zinc finger, FYVE domain containing 9	6					endocytosis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	early endosome membrane	metal ion binding|protein binding|receptor activity|serine-type peptidase activity	p.Q6*(1)		breast(1)|central_nervous_system(4)|endometrium(3)|kidney(1)|large_intestine(12)|lung(17)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	53						GAATTACTTCCAAGCAGAAGC	0.323000													30	45					0	0	1	0	0
UNC5C	8633	broad.mit.edu	37	4	96091388	96091388	+	Silent	SNP	C	C	T			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr4:96091388C>T	ENST00000453304.1	-	15	2895	c.2547G>A	c.(2545-2547)cgG>cgA	p.R849R		NM_003728.3	NP_003719.3	O95185	UNC5C_HUMAN	unc-5 homolog C (C. elegans)	849					apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(14)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	55		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		AGAGCTTCTGCCGGATAGGGA	0.602000													5	434					0	0	1	0	0
RP11-423O2.5	0	broad.mit.edu	37	1	142803543	142803543	+	RNA	SNP	C	C	T			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr1:142803543C>T	ENST00000423385.1	-	0	1422																											TGTTGGAATTCCTGATGAATC	0.269000													4	105					0	0	1	0	0
HEATR5A	25938	broad.mit.edu	37	14	31849768	31849768	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr14:31849768G>C	ENST00000543095.2	-	11	1797	c.1613C>G	c.(1612-1614)gCa>gGa	p.A538G	HEATR5A_ENST00000404677.3_Missense_Mutation_p.A538G|HEATR5A_ENST00000389961.3_Missense_Mutation_p.A532G|HEATR5A_ENST00000439727.1_Missense_Mutation_p.A245G|HEATR5A_ENST00000439348.1_Missense_Mutation_p.A532G	NM_015473.3	NP_056288.2	Q86XA9	HTR5A_HUMAN	HEAT repeat containing 5A	532							binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(13)|ovary(1)	26	Hepatocellular(127;0.0877)|Breast(36;0.137)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.0797)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.0059)		CAAATCCTCTGCTAATGTCAT	0.348000													6	8					0	0	1	0	0
CELSR1	9620	broad.mit.edu	37	22	46931804	46931804	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr22:46931804C>T	ENST00000262738.3	-	1	1263	c.1264G>A	c.(1264-1266)Gag>Aag	p.E422K	CELSR1_ENST00000395964.1_Missense_Mutation_p.E422K	NM_014246.1	NP_055061.1	Q9NYQ6	CELR1_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 1	422	Cadherin 2.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			breast(8)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(13)|lung(27)|ovary(2)|pancreas(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(3)	95		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		AGCTGGTACTCGGCCGCCTCC	0.682000													16	22					0	0	1	0	0
PXDN	7837	broad.mit.edu	37	2	1652648	1652648	+	Silent	SNP	G	G	A			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr2:1652648G>A	ENST00000252804.4	-	17	2954	c.2904C>T	c.(2902-2904)atC>atT	p.I968I		NM_012293.1	NP_036425.1	Q92626	PXDN_HUMAN	peroxidasin homolog (Drosophila)	968					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			breast(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(24)|lung(48)|ovary(3)|pancreas(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	112	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		GGAAGCAGGGGATGGGGCTCT	0.706000													4	16					0	0	1	0	0
HAO1	54363	broad.mit.edu	37	20	7894877	7894877	+	Missense_Mutation	SNP	T	T	C			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr20:7894877T>C	ENST00000378789.3	-	3	530	c.479A>G	c.(478-480)gAc>gGc	p.D160G		NM_017545.2	NP_060015.1	Q9UJM8	HAOX1_HUMAN	hydroxyacid oxidase (glycolate oxidase) 1	160	FMN hydroxy acid dehydrogenase.				cellular nitrogen compound metabolic process|fatty acid alpha-oxidation|glycolate catabolic process|glyoxylate metabolic process	peroxisomal matrix	FMN binding|glycolate oxidase activity|glyoxylate oxidase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(19)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36						GTAAGGTGTGTCCACTGTCAC	0.532000													22	68					0	0	1	0	0
KANSL3	55683	broad.mit.edu	37	2	97279275	97279275	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr2:97279275G>C	ENST00000599854.1	-	6	951	c.484C>G	c.(484-486)Ctg>Gtg	p.L162V	KANSL3_ENST00000487070.1_5'UTR|KANSL3_ENST00000441706.2_Missense_Mutation_p.L162V|KANSL3_ENST00000440133.1_Missense_Mutation_p.L43V|KANSL3_ENST00000431828.1_Missense_Mutation_p.L249V	NM_001115016.2	NP_001108488.1	Q9P2N6	K1310_HUMAN	KAT8 regulatory NSL complex subunit 3	249																	GGCCTCTTCAGTAGGAGAGAC	0.473000													54	106					0	0	1	0	0
DAPK1	1612	broad.mit.edu	37	9	90113996	90113996	+	Missense_Mutation	SNP	A	A	G			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr9:90113996A>G	ENST00000469640.2	+	2	379	c.4A>G	c.(4-6)Acc>Gcc	p.T2A	DAPK1_ENST00000472284.1_Missense_Mutation_p.T2A|DAPK1_ENST00000408954.3_Missense_Mutation_p.T2A|DAPK1_ENST00000358077.5_Missense_Mutation_p.T2A|DAPK1_ENST00000491893.1_Missense_Mutation_p.T2A			P53355	DAPK1_HUMAN	death-associated protein kinase 1	2					apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity			breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(27)|liver(2)|lung(17)|ovary(1)|prostate(2)|skin(3)|stomach(1)	72						GTTTATCATGACCGTGTTCAG	0.572000									Chronic Lymphocytic Leukemia, Familial Clustering of				12	18					0	0	1	0	0
OR52W1	120787	broad.mit.edu	37	11	6220873	6220873	+	Silent	SNP	G	G	T			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr11:6220873G>T	ENST00000311352.2	+	1	498	c.420G>T	c.(418-420)ctG>ctT	p.L140L		NM_001005178.1	NP_001005178.1	Q6IF63	O52W1_HUMAN	olfactory receptor, family 52, subfamily W, member 1	140					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(6)	11		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;2.13e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ACCCTGTCCTGGTCACCAAAG	0.542000													17	22					6.94344e-10	7.4599e-10	1	1	0
REG3A	5068	broad.mit.edu	37	2	79384769	79384769	+	Missense_Mutation	SNP	T	T	C			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr2:79384769T>C	ENST00000393878.1	-	4	643	c.389A>G	c.(388-390)tAc>tGc	p.Y130C	REG3A_ENST00000409839.3_Missense_Mutation_p.Y130C|REG3A_ENST00000305165.2_Missense_Mutation_p.Y130C	NM_138938.2	NP_620355.1	Q06141	REG3A_HUMAN	regenerating islet-derived 3 alpha	130	C-type lectin.				acute-phase response|cell proliferation|heterophilic cell-cell adhesion|multicellular organismal development	cytoplasm|extracellular space|soluble fraction	sugar binding			breast(2)|large_intestine(4)|lung(41)|prostate(2)|skin(1)	50						CCATGCAAAGTAATTCATCAC	0.547000													35	86					0	0	1	0	0
GZF1	64412	broad.mit.edu	37	20	23345049	23345049	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr20:23345049C>T	ENST00000338121.5	+	2	106	c.29C>T	c.(28-30)tCc>tTc	p.S10F	GZF1_ENST00000542987.1_Intron|GZF1_ENST00000544236.1_Intron|GZF1_ENST00000377051.2_Missense_Mutation_p.S10F			Q9H116	GZF1_HUMAN	GDNF-inducible zinc finger protein 1	10					transcription, DNA-dependent	nucleolus|nucleoplasm	sequence-specific DNA binding|zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(7)|prostate(1)|urinary_tract(2)	24	Lung NSC(19;0.0605)|Colorectal(13;0.0993)|all_lung(19;0.135)					CTGCTGGAATCCAAATCCTCC	0.478000													30	55					0	0	1	0	0
MSI1	4440	broad.mit.edu	37	12	120784110	120784110	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr12:120784110G>A	ENST00000257552.2	-	13	963	c.875C>T	c.(874-876)aCg>aTg	p.T292M		NM_002442.3	NP_002433.1	O43347	MSI1H_HUMAN	musashi RNA-binding protein 1	292					nervous system development	cytoplasm|nucleus	nucleotide binding			breast(4)|central_nervous_system(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(5)|skin(2)	19	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GGGAGCCATCGTCCAGGGGTG	0.692000													4	7					0	0	1	0	0
PON3	5446	broad.mit.edu	37	7	94989436	94989436	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr7:94989436C>T	ENST00000265627.5	-	9	924	c.914G>A	c.(913-915)cGc>cAc	p.R305H	PON1_ENST00000542556.1_Intron|PON3_ENST00000427422.1_Missense_Mutation_p.A235T	NM_000940.2	NP_000931.1			paraoxonase 3									p.R305H(1)		breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(2)|skin(2)	24	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0151)			ATTCTGGATGCGAAGTACCTG	0.438000													26	119					0	0	1	0	0
GIMAP6	474344	broad.mit.edu	37	7	150324890	150324890	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr7:150324890C>G	ENST00000328902.5	-	3	1012	c.796G>C	c.(796-798)Gag>Cag	p.E266Q	GIMAP6_ENST00000493969.1_3'UTR	NM_001244072.1|NM_024711.5	NP_001231001.1|NP_078987.3	Q6P9H5	GIMA6_HUMAN	GTPase, IMAP family member 6	266							GTP binding			endometrium(4)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	29			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AGCCAAGACTCCTCACCAGGC	0.537000													30	27					0	0	1	0	0
C12orf74	338809	broad.mit.edu	37	12	93100523	93100523	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr12:93100523G>A	ENST00000544406.2	+	2	382	c.116G>A	c.(115-117)cGg>cAg	p.R39Q	C12orf74_ENST00000397833.3_Missense_Mutation_p.R39Q			Q32Q52	CL074_HUMAN	chromosome 12 open reading frame 74	39								p.R39L(1)		kidney(1)|large_intestine(2)|lung(4)|prostate(1)|urinary_tract(2)	10						CAGTTTGACCGGCAAGCCCCA	0.627000													17	49					0	0	1	0	0
YARS2	51067	broad.mit.edu	37	12	32903678	32903678	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr12:32903678G>C	ENST00000324868.8	-	3	1105	c.1078C>G	c.(1078-1080)Cga>Gga	p.R360G		NM_001040436.2	NP_001035526.1	Q9Y2Z4	SYYM_HUMAN	tyrosyl-tRNA synthetase 2, mitochondrial	360					tyrosyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|protein binding|RNA binding|tyrosine-tRNA ligase activity			endometrium(1)|large_intestine(4)|lung(9)|prostate(1)|upper_aerodigestive_tract(1)	16	Lung NSC(5;2.43e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)				L-Tyrosine(DB00135)	AATCCTTCTCGTCCATGAACA	0.408000													29	68					0	0	1	0	0
C1orf177	163747	broad.mit.edu	37	1	55307479	55307479	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr1:55307479G>A	ENST00000371273.3	+	10	1205	c.1190G>A	c.(1189-1191)aGg>aAg	p.R397K	C1orf177_ENST00000358193.3_3'UTR	NM_001110533.1	NP_001104003.1	Q3ZCV2	CA177_HUMAN	chromosome 1 open reading frame 177	397										breast(1)|cervix(1)|kidney(1)|large_intestine(6)|lung(6)|prostate(2)	17						taaagggaaaggatcacacca	0.463000													3	5					0	0	1	0	0
TRABD2A	129293	broad.mit.edu	37	2	85066403	85066403	+	Silent	SNP	G	G	A			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr2:85066403G>A	ENST00000335459.5	-	3	919	c.714C>T	c.(712-714)atC>atT	p.I238I	TRABD2A_ENST00000409133.1_Silent_p.I287I|TRABD2A_ENST00000409520.2_Silent_p.I287I	NM_001080824.1	NP_001074293.1			TraB domain containing 2A																		CCTGAGCAGTGATGCGCTCCT	0.463000													14	25					0	0	1	0	0
CARD6	84674	broad.mit.edu	37	5	40854448	40854448	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr5:40854448C>G	ENST00000254691.5	+	3	3213	c.3014C>G	c.(3013-3015)tCt>tGt	p.S1005C	CARD6_ENST00000381677.3_Intron	NM_032587.3	NP_115976.2	Q9BX69	CARD6_HUMAN	caspase recruitment domain family, member 6	1005	Pro-rich.				apoptosis|regulation of apoptosis	intracellular				NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(2)|lung(29)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	62						TCTAAGCCTTCTCAGCCCAGA	0.527000													155	636					0	0	1	0	0
NRG2	9542	broad.mit.edu	37	5	139422532	139422534	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr5:139422532_139422534delGCT	ENST00000541337.1	-	1	350_352	c.121_123delAGC	c.(121-123)del	p.S41del	NRG2_ENST00000545385.1_In_Frame_Del_p.S41del|NRG2_ENST00000289409.4_In_Frame_Del_p.S41del|NRG2_ENST00000358522.3_In_Frame_Del_p.S41del|NRG2_ENST00000289422.7_In_Frame_Del_p.S41del|NRG2_ENST00000361474.1_In_Frame_Del_p.S41del|NRG2_ENST00000394770.1_In_Frame_Del_p.S41del	NM_001184935.1	NP_001171864.1	O14511	NRG2_HUMAN	neuregulin 2	41	Poly-Ser.				embryo development	extracellular region|integral to membrane|plasma membrane	growth factor activity	p.S41delS(2)		breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(5)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	25			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			tgccgctctcgctgctgctgctg	0.700													2	4	---	---	---	---					
NSD1	64324	broad.mit.edu	37	5	176710861	176710861	+	Frame_Shift_Del	DEL	A	A	-			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr5:176710861delA	ENST00000439151.2	+	20	6128	c.6083delA	c.(6082-6084)gafs	p.E2028fs	NSD1_ENST00000361032.4_Frame_Shift_Del_p.E1925fs|NSD1_ENST00000354179.4_Frame_Shift_Del_p.E1759fs|NSD1_ENST00000347982.4_Frame_Shift_Del_p.E1759fs	NM_022455.4	NP_071900.2	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	2028	SET.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(18)|lung(24)|ovary(2)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(3)	96	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		CCCAACTGTGAAACACAGAAG	0.443			T	NUP98	AML		Sotos Syndrome		Weaver syndrome;Sotos syndrome;Beckwith-Wiedemann syndrome	HNSCC(47;0.14)			62	43	---	---	---	---					
PTCH1	5727	broad.mit.edu	37	9	98224262	98224263	+	Frame_Shift_Ins	INS	-	-	A			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr9:98224262_98224263insA	ENST00000430669.2	-	16	2965_2966	c.2380_2381insT	c.(2380-2382)cagfs	p.Q794fs	PTCH1_ENST00000437951.1_Frame_Shift_Ins_p.Q794fs|PTCH1_ENST00000331920.6_Frame_Shift_Ins_p.Q860fs|PTCH1_ENST00000418258.1_Frame_Shift_Ins_p.Q709fs|PTCH1_ENST00000421141.1_Frame_Shift_Ins_p.Q709fs|PTCH1_ENST00000429896.2_Frame_Shift_Ins_p.Q709fs|PTCH1_ENST00000375274.2_Frame_Shift_Ins_p.Q859fs			Q13635	PTC1_HUMAN	patched 1	860					embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity			NS(8)|bone(33)|breast(10)|central_nervous_system(95)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(8)|kidney(2)|large_intestine(18)|lung(22)|meninges(1)|oesophagus(3)|ovary(6)|prostate(2)|skin(262)|upper_aerodigestive_tract(11)|urinary_tract(2)|vulva(1)	490		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				CCAGTCACTGTCAAATGCATCC	0.500													81	40	---	---	---	---					
DLG5	9231	broad.mit.edu	37	10	79613112	79613114	+	Splice_Site	DEL	CTG	CTG	-			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr10:79613112_79613114delCTG	ENST00000372391.2	-	5	867_869	c.864_splice	c.e5+1	p.Q288_splice	DLG5_ENST00000372388.2_Splice_Site_p.Q288_splice	NM_004747.3	NP_004738.3	Q8TDM6	DLG5_HUMAN	discs, large homolog 5 (Drosophila)	288					cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			breast(9)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(17)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	60	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			ctgggCCTACCTGCTGCTGCTGG	0.576													2	4	---	---	---	---					
TRAV9-2	28677	broad.mit.edu	37	14	22409532	22409540	+	RNA	DEL	TCTCTCTCT	TCTCTCTCT	-	rs57759840		TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr14:22409532_22409540delTCTCTCTCT	ENST00000390441.2	+	0	102																											tctctctctctctctctctTTTTTTTTTT	0.411													4	4	---	---	---	---					
HERC2P2	400322	broad.mit.edu	37	15	23312380	23312380	+	RNA	DEL	T	T	-			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr15:23312380delT	ENST00000560464.1	-	0	3118																											TGTTAttttcttttttttttt	0.398													3	5	---	---	---	---					
TP53	7157	broad.mit.edu	37	17	7578262	7578277	+	Frame_Shift_Del	DEL	CGGATAAGATGCTGAG	CGGATAAGATGCTGAG	-			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr17:7578262_7578277delCGGATAAGATGCTGAG	ENST00000420246.2	-	6	704_719	c.572_587delCTCAGCATCTTATCCG	c.(571-588)cafs	p.PQHLIR191fs	TP53_ENST00000455263.2_Frame_Shift_Del_p.PQHLIR191fs|TP53_ENST00000269305.4_Frame_Shift_Del_p.PQHLIR191fs|TP53_ENST00000413465.2_Frame_Shift_Del_p.PQHLIR191fs|TP53_ENST00000574684.1_Intron|TP53_ENST00000359597.4_Frame_Shift_Del_p.PQHLIR191fs|TP53_ENST00000445888.2_Frame_Shift_Del_p.PQHLIR191fs	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	191	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		P -> H (in sporadic cancers; somatic mutation).|P -> L (in sporadic cancers; somatic mutation).|P -> R (in sporadic cancers; somatic mutation).|P -> S (in sporadic cancers; somatic mutation).|P -> T (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R196*(167)|p.Q192*(83)|p.H193R(80)|p.I195T(69)|p.L194R(47)|p.H193L(42)|p.H193Y(29)|p.I195F(20)|p.R196P(18)|p.H193P(18)|p.L194F(17)|p.R64*(14)|p.R103*(14)|p.H193D(13)|p.I195N(12)|p.I195S(10)|p.L194P(8)|p.L194H(8)|p.0?(8)|p.P191del(7)|p.R196fs*51(7)|p.?(6)|p.I195fs*52(6)|p.Q99*(6)|p.I195fs*14(6)|p.Q60*(6)|p.L62R(5)|p.L101R(5)|p.Q192R(5)|p.P191delP(4)|p.H61R(4)|p.H100L(4)|p.H61L(4)|p.H100R(4)|p.L194L(4)|p.H193N(4)|p.A189_V197delAPPQHLIRV(4)|p.I195M(3)|p.R196Q(3)|p.H193fs*16(3)|p.P191_E198>Q(3)|p.Q192H(3)|p.P191L(2)|p.P191fs*53(2)|p.I102S(2)|p.I102T(2)|p.P59delP(2)|p.H61P(2)|p.I63T(2)|p.H100P(2)|p.I63S(2)|p.H61D(2)|p.H100D(2)|p.R103P(2)|p.G187fs*16(2)|p.R64P(2)|p.L194fs*15(2)|p.P191R(2)|p.P98delP(2)|p.H193H(2)|p.Q192Q(2)|p.R196R(2)|p.R64fs*>27(1)|p.R103fs*51(1)|p.P59_E66>Q(1)|p.P191fs*56(1)|p.I102M(1)|p.I102F(1)|p.L188_P191del(1)|p.Q192fs*30(1)|p.I102fs*14(1)|p.I195fs*50(1)|p.R196L(1)|p.L194fs*52(1)|p.P98_E105>Q(1)|p.H100Y(1)|p.H61Y(1)|p.Q192fs*16(1)|p.I195L(1)|p.I63fs*14(1)|p.P191fs*6(1)|p.H193_I195delHLI(1)|p.P191fs*15(1)|p.I195_G199delIRVEG(1)|p.L62H(1)|p.A189fs*53(1)|p.A189_Q192>E(1)|p.L194V(1)|p.L194I(1)|p.I102fs*52(1)|p.I195fs*12(1)|p.I63M(1)|p.P191H(1)|p.L194fs*14(1)|p.P191P(1)|p.L101H(1)|p.P191_Q192delPQ(1)|p.D186_P191delDGLAPP(1)|p.Q192>XXXXXXXXX(1)|p.Q192K(1)|p.I63F(1)|p.I63fs*>28(1)|p.Q192fs*56(1)|p.Q192del(1)|p.H193_I195>AP(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCCTTCCACTCGGATAAGATGCTGAGGAGGGGCCAG	0.551		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			21	16	---	---	---	---					
KIZ-AS1	101929591	broad.mit.edu	37	20	21142442	21142442	+	RNA	DEL	A	A	-	rs113752643		TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr20:21142442delA	ENST00000591761.1	-	0	5142				PLK1S1_ENST00000457464.1_RNA|RP5-872K7.7_ENST00000425746.2_RNA																							TCATTTCTGGAAAAAAAAAAA	0.363													3	6	---	---	---	---					
CELSR1	9620	broad.mit.edu	37	22	46761484	46761484	+	Splice_Site	DEL	A	A	-			TCGA-D6-A6EO-01A-11D-A31L-08	TCGA-D6-A6EO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	710de6ca-2401-4b9c-b803-1086cc6b775d	88414f62-bce3-45d4-8925-a108cc4b2501	g.chr22:46761484delA	ENST00000262738.3	-	31	8402	c.8404_splice	c.e31+1	p.P2801_splice		NM_014246.1	NP_055061.1	Q9NYQ6	CELR1_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 1	2801					central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			breast(8)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(13)|lung(27)|ovary(2)|pancreas(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(3)	95		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		AAGCCATACCAGGGGGATCCT	0.637													2	4	---	---	---	---