Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
GOLGA3	2802	broad.mit.edu	37	12	133393134	133393134	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr12:133393134G>A	ENST00000204726.3	-	3	956	c.398C>T	c.(397-399)aCg>aTg	p.T133M	GOLGA3_ENST00000456883.2_Missense_Mutation_p.T133M|GOLGA3_ENST00000450791.2_Missense_Mutation_p.T133M|GOLGA3_ENST00000537452.1_Missense_Mutation_p.T133M|GOLGA3_ENST00000545875.1_Missense_Mutation_p.T133M	NM_005895.3	NP_005886.2	Q08378	GOGA3_HUMAN	golgin A3	133	Interaction with GOPC.				intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		ACACAGTTGCGTTTCTTGCAT	0.542000													14	46					0	0	1	0	0
LHX4	89884	broad.mit.edu	37	1	180199676	180199676	+	Silent	SNP	T	T	C			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr1:180199676T>C	ENST00000263726.2	+	1	256	c.12T>C	c.(10-12)agT>agC	p.S4S		NM_033343.3	NP_203129.1	Q969G2	LHX4_HUMAN	LIM homeobox 4	4						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(1)	16						TGATGCAGAGTGCGACTGTCC	0.517000													4	14					0	0	1	0	0
DNTTIP1	116092	broad.mit.edu	37	20	44439738	44439738	+	Silent	SNP	C	C	T			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr20:44439738C>T	ENST00000372622.3	+	13	962	c.894C>T	c.(892-894)gtC>gtT	p.V298V		NM_052951.2	NP_443183.1	Q9H147	TDIF1_HUMAN	deoxynucleotidyltransferase, terminal, interacting protein 1	298						nucleus				breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(2)|prostate(1)	9		Myeloproliferative disorder(115;0.0122)				AATCCTTTGTCCTACCCTCCT	0.502000													15	77					0	0	1	0	0
MYO1B	4430	broad.mit.edu	37	2	192278879	192278879	+	Silent	SNP	G	G	A			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr2:192278879G>A	ENST00000392318.3	+	28	3226	c.2979G>A	c.(2977-2979)gtG>gtA	p.V993V	MYO1B_ENST00000392316.1_Silent_p.V964V|MYO1B_ENST00000339514.4_Silent_p.V935V|MYO1B_ENST00000439065.2_Silent_p.V238V|MYO1B_ENST00000304164.4_Silent_p.V993V	NM_001130158.1	NP_001123630.1	O43795	MYO1B_HUMAN	myosin IB	993						myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|central_nervous_system(6)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(19)|ovary(1)	55			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.104)|all cancers(119;0.236)			CTGAAGTCGTGAACAAAATTA	0.393000													30	85					0	0	1	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96593016	96593016	+	Missense_Mutation	SNP	C	C	A	rs79307257	by1000genomes	TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr2:96593016C>A	ENST00000456556.1	-	28	1969	c.1885G>T	c.(1885-1887)Gat>Tat	p.D629Y						ankyrin repeat domain 36C									p.D629Y(1)		breast(1)|endometrium(8)|kidney(5)|lung(4)	18						GAAACAGAATCTTTCTCATCA	0.318000													3	35					1	1	1	1	0
ASZ1	136991	broad.mit.edu	37	7	117067495	117067495	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr7:117067495C>T	ENST00000284629.2	-	1	82	c.20G>A	c.(19-21)cGa>cAa	p.R7Q		NM_130768.2	NP_570124.1	Q8WWH4	ASZ1_HUMAN	ankyrin repeat, SAM and basic leucine zipper domain containing 1	7					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	signal transducer activity	p.R7Q(1)		breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|prostate(3)|skin(1)	24	Lung NSC(10;0.00156)|all_lung(10;0.00175)		STAD - Stomach adenocarcinoma(10;0.000512)			TGGCAGGCCTCGCAGCGCGCT	0.697000											OREG0003439	type=REGULATORY REGION|Gene=ASZ1|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	18	49					0	0	1	0	0
SLC26A9	115019	broad.mit.edu	37	1	205886433	205886433	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr1:205886433C>T	ENST00000367135.3	-	20	2419	c.2306G>A	c.(2305-2307)cGc>cAc	p.R769H	SLC26A9_ENST00000367134.2_Missense_Mutation_p.R769H|SLC26A9_ENST00000340781.4_Missense_Mutation_p.R769H	NM_052934.3	NP_443166.1	Q7LBE3	S26A9_HUMAN	solute carrier family 26 (anion exchanger), member 9	769						integral to membrane	chloride channel activity|secondary active sulfate transmembrane transporter activity			NS(1)|breast(3)|endometrium(11)|kidney(1)|large_intestine(6)|lung(17)|ovary(1)|skin(7)|urinary_tract(5)	52	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0458)			CCAGTAGCTGCGAATGTCCTC	0.577000													57	153					0	0	1	0	0
MAPK12	6300	broad.mit.edu	37	22	50694559	50694559	+	Missense_Mutation	SNP	G	G	A	rs147362308		TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr22:50694559G>A	ENST00000215659.8	-	7	889	c.574C>T	c.(574-576)Cgg>Tgg	p.R192W	MAPK12_ENST00000497036.1_5'UTR|MAPK12_ENST00000395780.1_Missense_Mutation_p.R102W	NM_002969.3	NP_002960.2	P53778	MK12_HUMAN	mitogen-activated protein kinase 12	192	Protein kinase.				cell cycle arrest|DNA damage induced protein phosphorylation|muscle organ development|myoblast differentiation|nerve growth factor receptor signaling pathway|positive regulation of muscle cell differentiation|Ras protein signal transduction	mitochondrion|nucleoplasm	ATP binding|magnesium ion binding|MAP kinase activity|protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(2)|skin(1)	8		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		TCGGGAGCCCGGTACCACCGG	0.602000													13	43					0	0	1	0	0
BCL11A	53335	broad.mit.edu	37	2	60688664	60688664	+	Silent	SNP	G	G	A			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr2:60688664G>A	ENST00000335712.6	-	4	1610	c.1383C>T	c.(1381-1383)agC>agT	p.S461S	BCL11A_ENST00000538214.1_Silent_p.S427S|BCL11A_ENST00000356842.4_Silent_p.S461S|BCL11A_ENST00000477659.1_5'UTR|BCL11A_ENST00000358510.4_Silent_p.S427S|BCL11A_ENST00000537768.1_Silent_p.S130S|BCL11A_ENST00000359629.5_Intron	NM_022893.3	NP_075044.2	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A (zinc finger protein)	461					negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			NS(1)|breast(6)|central_nervous_system(6)|endometrium(4)|kidney(1)|large_intestine(8)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	59			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			ACTTGAGCGCGCTGCTGGCGC	0.647000			T	IGH@	B-CLL								6	22					0	0	1	0	0
MCM8	84515	broad.mit.edu	37	20	5948132	5948132	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr20:5948132G>A	ENST00000378896.3	+	9	1303	c.926G>A	c.(925-927)cGa>cAa	p.R309Q	MCM8_ENST00000378883.1_Missense_Mutation_p.R309Q|MCM8_ENST00000265187.4_Missense_Mutation_p.R309Q|MCM8_ENST00000378886.2_Missense_Mutation_p.R309Q	NM_032485.4|NM_182802.1	NP_115874.3|NP_877954.1	Q9UJA3	MCM8_HUMAN	minichromosome maintenance complex component 8	309					cell cycle checkpoint|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|nucleoside-triphosphatase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	23						CGGATTCCACGAACAATAGAA	0.393000													21	56					0	0	1	0	0
IGSF1	3547	broad.mit.edu	37	X	130412550	130412550	+	Silent	SNP	C	C	T			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chrX:130412550C>T	ENST00000370904.1	-	18	2809	c.1899G>A	c.(1897-1899)cgG>cgA	p.R633R	IGSF1_ENST00000361420.3_Silent_p.R642R|IGSF1_ENST00000370910.1_Silent_p.R633R|IGSF1_ENST00000370903.3_Silent_p.R647R			Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1	642	Ig-like C2-type 6.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|liver(1)|lung(37)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)	78						GGAAGGCAGCCCGGACCTGCT	0.632000													25	30					0	0	1	0	0
NRG3	10718	broad.mit.edu	37	10	83635703	83635703	+	Missense_Mutation	SNP	A	A	T			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr10:83635703A>T	ENST00000404547.1	+	1	607	c.607A>T	c.(607-609)Agc>Tgc	p.S203C	NRG3_ENST00000372141.2_Missense_Mutation_p.S203C			P56975	NRG3_HUMAN	neuregulin 3	203	Ser/Thr-rich.				regulation of cell growth	extracellular region|integral to plasma membrane	growth factor activity|receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(41)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	69				GBM - Glioblastoma multiforme(1;2.5e-18)|all cancers(1;2.85e-09)		GTTCTTCAGTAGCAGCACGCT	0.692000													9	22					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2721074	2721074	+	Silent	SNP	C	C	T			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr12:2721074C>T	ENST00000399655.1	+	29	3988	c.3723C>T	c.(3721-3723)taC>taT	p.Y1241Y	CACNA1C_ENST00000399641.1_Silent_p.Y1241Y|CACNA1C_ENST00000399606.1_Silent_p.Y1261Y|CACNA1C_ENST00000347598.4_Silent_p.Y1261Y|CACNA1C_ENST00000344100.3_Silent_p.Y1241Y|CACNA1C_ENST00000327702.7_Silent_p.Y1241Y|CACNA1C_ENST00000480911.1_Silent_p.Y1241Y|CACNA1C_ENST00000399649.1_Silent_p.Y1241Y|CACNA1C_ENST00000399591.1_Silent_p.Y1241Y|CACNA1C_ENST00000399637.1_Silent_p.Y1241Y|CACNA1C_ENST00000399621.1_Silent_p.Y1241Y|CACNA1C_ENST00000399595.1_Silent_p.Y1241Y|CACNA1C_ENST00000399634.1_Silent_p.Y1241Y|CACNA1C_ENST00000399597.1_Silent_p.Y1241Y|CACNA1C_ENST00000399629.1_Silent_p.Y1241Y|CACNA1C_ENST00000399638.1_Silent_p.Y1241Y|CACNA1C_ENST00000399644.1_Silent_p.Y1241Y|CACNA1C_ENST00000399617.1_Silent_p.Y1241Y|CACNA1C_ENST00000399601.1_Silent_p.Y1241Y|CACNA1C_ENST00000406454.3_Silent_p.Y1241Y|CACNA1C_ENST00000335762.5_Silent_p.Y1266Y|CACNA1C_ENST00000402845.3_Silent_p.Y1241Y|CACNA1C_ENST00000399603.1_Silent_p.Y1241Y	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	1261					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	TGCAGCACTACGGCCAGAGCT	0.577000													9	15					0	0	1	0	0
ERV3-1	2086	broad.mit.edu	37	7	64452634	64452634	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr7:64452634G>C	ENST00000394323.2	-	2	1271	c.771C>G	c.(769-771)ttC>ttG	p.F257L		NM_001007253.3	NP_001007254.2	Q14264	ENR1_HUMAN		257						virion				breast(1)|cervix(1)|endometrium(3)|large_intestine(3)|lung(8)	16						catgctcatagaatgactcaa	0.473000													12	40					0	0	1	0	0
CHDC2	286464	broad.mit.edu	37	X	36091266	36091266	+	Silent	SNP	A	A	C			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chrX:36091266A>C	ENST00000378660.1	+	4	389	c.201A>C	c.(199-201)gtA>gtC	p.V67V	CHDC2_ENST00000313548.4_Silent_p.V67V					calponin homology domain containing 2																		GAGTGGAAGTACTGCCTGAAA	0.348000													6	12					0	0	1	0	0
CENPF	1063	broad.mit.edu	37	1	214816112	214816112	+	Silent	SNP	A	A	G			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr1:214816112A>G	ENST00000366955.3	+	12	4599	c.4431A>G	c.(4429-4431)tcA>tcG	p.S1477S		NM_016343.3	NP_057427.3	P49454	CENPF_HUMAN	centromere protein F, 350/400kDa	1573	2 X 96 AA approximate tandem repeats.				cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			NS(2)|breast(2)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(37)|lung(47)|ovary(7)|prostate(3)|skin(6)|stomach(1)|urinary_tract(1)	126				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		CATCCCTGTCATCCTCTTGTG	0.473000													19	41					0	0	1	0	0
BOD1L1	259282	broad.mit.edu	37	4	13600626	13600626	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr4:13600626G>T	ENST00000040738.5	-	10	8033	c.7898C>A	c.(7897-7899)cCt>cAt	p.P2633H		NM_148894.2	NP_683692.2	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division 1-like 1	2633							DNA binding										TCCTTCCTCAGGGAATGATTT	0.373000													5	75					0.184627	0.186048	1	1	0
DZIP1L	199221	broad.mit.edu	37	3	137822609	137822609	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr3:137822609G>A	ENST00000327532.2	-	2	567	c.205C>T	c.(205-207)Cgg>Tgg	p.R69W	DZIP1L_ENST00000469243.1_Missense_Mutation_p.R69W	NM_173543.2	NP_775814.2	Q8IYY4	DZI1L_HUMAN	DAZ interacting zinc finger protein 1-like	69						intracellular	zinc ion binding	p.R69W(1)		breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(1)|pancreas(2)|prostate(1)|skin(1)	35						CACACCTCCCGGTCCAAGTTG	0.617000													9	55					0	0	1	0	0
NAP1L3	4675	broad.mit.edu	37	X	92927176	92927176	+	Silent	SNP	T	T	A			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chrX:92927176T>A	ENST00000373079.3	-	1	1391	c.1128A>T	c.(1126-1128)acA>acT	p.T376T	NAP1L3_ENST00000475430.1_5'UTR	NM_004538.5	NP_004529.2	Q99457	NP1L3_HUMAN	nucleosome assembly protein 1-like 3	376					nucleosome assembly	chromatin assembly complex				haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(16)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	34						TTATTATATATGTCTTCACCA	0.408000													8	14					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216373122	216373122	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr1:216373122C>A	ENST00000366943.2	-	17	4044	c.3658G>T	c.(3658-3660)Gta>Tta	p.V1220L	USH2A_ENST00000366942.3_Missense_Mutation_p.V1220L|RP5-1099E6.3_ENST00000420867.1_RNA|USH2A_ENST00000307340.3_Missense_Mutation_p.V1220L			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	1220	Fibronectin type-III 2.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CACGCCTGTACAGAAAAATCG	0.517000										HNSCC(13;0.011)			13	62					0.00010058	0.000106258	1	1	0
ZNF235	9310	broad.mit.edu	37	19	44792818	44792818	+	Missense_Mutation	SNP	T	T	C			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr19:44792818T>C	ENST00000291182.4	-	5	872	c.770A>G	c.(769-771)cAc>cGc	p.H257R	ZNF235_ENST00000589248.1_Intron|ZNF235_ENST00000589799.1_Intron	NM_004234.4	NP_004225.3	Q14590	ZN235_HUMAN	zinc finger protein 235	257					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	29		Prostate(69;0.0352)|all_neural(266;0.116)				CTGTCCTGTGTGAATACTACG	0.388000													12	53					0	0	1	0	0
VIPAS39	63894	broad.mit.edu	37	14	77914882	77914882	+	Missense_Mutation	SNP	A	A	T			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr14:77914882A>T	ENST00000553888.1	-	7	969	c.459T>A	c.(457-459)aaT>aaA	p.N153K	VIPAS39_ENST00000557658.1_Missense_Mutation_p.N153K|VIPAS39_ENST00000556412.1_Missense_Mutation_p.N179K|VIPAS39_ENST00000448935.2_Missense_Mutation_p.N104K|VIPAS39_ENST00000343765.2_Missense_Mutation_p.N153K|VIPAS39_ENST00000327028.4_Missense_Mutation_p.N140K	NM_001193314.1|NM_001193317.1|NM_022067.3	NP_001180243.1|NP_001180246.1|NP_071350.2			VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog																		GGCTCCAGTCATTGCTGTAAT	0.463000													41	34					0	0	1	0	0
TPTE	7179	broad.mit.edu	37	21	10970031	10970031	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr21:10970031C>T	ENST00000298232.7	-	6	464	c.97G>A	c.(97-99)Gag>Aag	p.E33K	TPTE_ENST00000361285.4_Missense_Mutation_p.E33K|TPTE_ENST00000342420.5_Missense_Mutation_p.E33K|TPTE_ENST00000415664.2_5'UTR	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	33					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GGTGCCTCCTCGGTTGCTCCT	0.393000													6	115					0	0	1	0	0
ZNF189	7743	broad.mit.edu	37	9	104171678	104171678	+	Missense_Mutation	SNP	A	A	T			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr9:104171678A>T	ENST00000374861.3	+	3	1870	c.1586A>T	c.(1585-1587)gAt>gTt	p.D529V	ZNF189_ENST00000339664.2_Missense_Mutation_p.D543V|ZNF189_ENST00000259395.4_Missense_Mutation_p.D501V	NM_001278231.1|NM_001278232.1|NM_003452.2	NP_001265160.1|NP_001265161.1|NP_003443.2	O75820	ZN189_HUMAN	zinc finger protein 189	543					negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(10)|ovary(2)|prostate(3)|skin(2)|urinary_tract(1)	26		Acute lymphoblastic leukemia(62;0.0559)				CATAAATGTGATGAATGTGGA	0.423000													13	55					0	0	1	0	0
OR2G6	391211	broad.mit.edu	37	1	248685295	248685295	+	Silent	SNP	C	C	T			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr1:248685295C>T	ENST00000343414.4	+	1	380	c.348C>T	c.(346-348)gcC>gcT	p.A116A		NM_001013355.1	NP_001013373.1	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G, member 6	116					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(1)|endometrium(2)|large_intestine(7)|lung(40)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	61	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TTCTCTTGGCCGTCATGGCTT	0.557000													4	75					0	0	1	0	0
GDF6	392255	broad.mit.edu	37	8	97157145	97157145	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr8:97157145G>T	ENST00000287020.5	-	2	1113	c.1014C>A	c.(1012-1014)ttC>ttA	p.F338L		NM_001001557.2	NP_001001557.1	Q6KF10	GDF6_HUMAN	growth differentiation factor 6	338					activin receptor signaling pathway|BMP signaling pathway|growth|pathway-restricted SMAD protein phosphorylation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			breast(2)|cervix(1)|endometrium(1)|large_intestine(5)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	27	Breast(36;2.67e-05)					GGCGACTGGCGAAGGCCGTgc	0.746000													9	17					2.17888e-05	2.33961e-05	1	1	0
KIAA0947	23379	broad.mit.edu	37	5	5464410	5464410	+	Missense_Mutation	SNP	T	T	C			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr5:5464410T>C	ENST00000296564.7	+	13	5185	c.4963T>C	c.(4963-4965)Tcg>Ccg	p.S1655P		NM_015325.2	NP_056140.1	Q9Y2F5	K0947_HUMAN	KIAA0947	1655	Pro-rich.									breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(14)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)	35						TCCACTGATATCGAGTTCTAG	0.567000													36	140					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	4091409	4091409	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr7:4091409C>T	ENST00000404826.2	+	19	2997	c.2858C>T	c.(2857-2859)aCc>aTc	p.T953I	SDK1_ENST00000389531.3_Missense_Mutation_p.T953I	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	953	Fibronectin type-III 3.				cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		TGCTTCACCACCCCTGGGGAC	0.527000													26	80					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14819319	14819319	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr9:14819319G>C	ENST00000380881.4	-	15	3277	c.2462C>G	c.(2461-2463)cCt>cGt	p.P821R	FREM1_ENST00000422223.2_Missense_Mutation_p.P820R|FREM1_ENST00000380880.3_Missense_Mutation_p.P820R			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	820					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		TCCGTGCAGAGGCAATTCCCG	0.468000													9	16					0	0	1	0	0
SNX25	83891	broad.mit.edu	37	4	186272622	186272622	+	Silent	SNP	G	G	C			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr4:186272622G>C	ENST00000504273.1	+	14	2127	c.1833G>C	c.(1831-1833)ctG>ctC	p.L611L	SNX25_ENST00000264694.8_Silent_p.L611L|SNX25_ENST00000512853.1_Intron			Q9H3E2	SNX25_HUMAN	sorting nexin 25	611	PX.				cell communication|protein transport	endosome membrane	phosphatidylinositol binding|signal transducer activity			NS(1)|breast(4)|endometrium(2)|kidney(4)|large_intestine(8)|lung(13)|ovary(2)|pancreas(2)|prostate(2)|urinary_tract(2)	40		all_lung(41;1.03e-13)|Lung NSC(41;2.5e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00886)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;2.13e-24)|Epithelial(43;6.15e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.6e-11)|BRCA - Breast invasive adenocarcinoma(30;0.00013)|Colorectal(24;0.000165)|GBM - Glioblastoma multiforme(59;0.000357)|COAD - Colon adenocarcinoma(29;0.000887)|STAD - Stomach adenocarcinoma(60;0.00118)|LUSC - Lung squamous cell carcinoma(40;0.0129)|READ - Rectum adenocarcinoma(43;0.228)		ATGAAAGACTGTGTCAGAGTG	0.438000													13	45					0	0	1	0	0
GRM8	2918	broad.mit.edu	37	7	126883110	126883110	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr7:126883110C>T	ENST00000339582.2	-	2	957	c.149G>A	c.(148-150)gGt>gAt	p.G50D	GRM8_ENST00000405249.1_Missense_Mutation_p.G50D|GRM8_ENST00000358373.3_Missense_Mutation_p.G50D|GRM8_ENST00000444921.2_Missense_Mutation_p.G50D			O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8	50					negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(16)|lung(62)|ovary(5)|pancreas(1)|prostate(1)|skin(14)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(4)	125		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	AGGGAAGAGACCCCCCAAAAT	0.517000										HNSCC(24;0.065)			9	70					0	0	1	0	0
PPP1R8	5511	broad.mit.edu	37	1	28176681	28176681	+	Silent	SNP	C	C	T			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr1:28176681C>T	ENST00000373931.4	+	7	1149	c.354C>T	c.(352-354)agC>agT	p.S118S	PPP1R8_ENST00000311772.5_Silent_p.S260S|PPP1R8_ENST00000236412.7_Silent_p.S36S|PPP1R8_ENST00000486634.1_3'UTR	NM_138558.2	NP_612568.1	Q12972	PP1R8_HUMAN	protein phosphatase 1, regulatory subunit 8	260	Interaction with CDC5L, SF3B1 and MELK.				mRNA processing|regulation of transcription, DNA-dependent|RNA catabolic process|RNA splicing|transcription, DNA-dependent	cytoplasm|nuclear speck|spliceosomal complex	DNA binding|endonuclease activity|protein binding|protein serine/threonine phosphatase inhibitor activity|ribonuclease E activity|RNA binding			breast(2)|cervix(1)|endometrium(2)|lung(2)|upper_aerodigestive_tract(1)	8		Colorectal(325;3.46e-05)|all_lung(284;0.000129)|Lung NSC(340;0.000259)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0419)|OV - Ovarian serous cystadenocarcinoma(117;2.76e-24)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00248)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0649)		TTGCCTTCAGCGGAGGACTCT	0.622000													47	195					0	0	1	0	0
GLCCI1	113263	broad.mit.edu	37	7	8110672	8110672	+	Missense_Mutation	SNP	A	A	G	rs148958007		TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr7:8110672A>G	ENST00000223145.5	+	6	1645	c.1088A>G	c.(1087-1089)cAt>cGt	p.H363R		NM_138426.3	NP_612435.1	Q86VQ1	GLCI1_HUMAN	glucocorticoid induced transcript 1	363										endometrium(4)|large_intestine(4)|lung(13)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	25		Ovarian(82;0.0608)		UCEC - Uterine corpus endometrioid carcinoma (126;0.206)		TGCAGCAGTCATTCACCCTGT	0.517000													23	92					0	0	1	0	0
ABCC9	10060	broad.mit.edu	37	12	22012543	22012543	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr12:22012543G>C	ENST00000261200.4	-	20	2481	c.2482C>G	c.(2482-2484)Caa>Gaa	p.Q828E	ABCC9_ENST00000345162.2_Missense_Mutation_p.Q792E|ABCC9_ENST00000261201.4_Missense_Mutation_p.Q828E|RP11-729I10.2_ENST00000539874.1_RNA	NM_020297.2	NP_064693.2	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	828	ABC transporter 1.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity	p.Q828*(2)		NS(2)|breast(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|lung(56)|ovary(4)|pancreas(1)|prostate(4)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(5)	118					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	TTGGTGTTTTGATACAGCGCT	0.408000													30	90					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196750966	196750966	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr2:196750966C>T	ENST00000312428.6	-	34	5537	c.5437G>A	c.(5437-5439)Gtc>Atc	p.V1813I		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1813					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						AAGGACCGGACCAAGTTTGTA	0.333000													5	38					0	0	1	0	0
TRAV5	28688	broad.mit.edu	37	14	22217750	22217750	+	RNA	SNP	G	G	A			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr14:22217750G>A	ENST00000390427.3	+	0	113																											CTGAGTGTCCGAGAGGGAGAC	0.483000													9	23					0	0	1	0	0
ZNF648	127665	broad.mit.edu	37	1	182026642	182026642	+	Silent	SNP	G	G	T			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr1:182026642G>T	ENST00000339948.3	-	2	711	c.504C>A	c.(502-504)ccC>ccA	p.P168P		NM_001009992.1	NP_001009992.1	Q5T619	ZN648_HUMAN	zinc finger protein 648	168					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(7)|large_intestine(10)|lung(17)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	40						TTCCATTGCTGGGGAAGCTGG	0.567000													7	29					0.000157383	0.000163629	1	1	0
ZNFX1	57169	broad.mit.edu	37	20	47886636	47886636	+	Silent	SNP	T	T	A			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr20:47886636T>A	ENST00000396105.1	-	3	1959	c.1713A>T	c.(1711-1713)ctA>ctT	p.L571L	ZNFX1_ENST00000371754.4_Silent_p.L571L|ZNFX1_ENST00000371752.1_Silent_p.L571L	NM_021035.2	NP_066363.1	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	571							metal ion binding			cervix(2)|endometrium(8)|kidney(7)|large_intestine(15)|liver(1)|lung(17)|ovary(2)|prostate(4)|skin(3)|urinary_tract(1)	60			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			CGACATTTCTTAGAAATTCCC	0.478000													26	94					0	0	1	0	0
SALL3	27164	broad.mit.edu	37	18	76756969	76756969	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr18:76756969C>G	ENST00000536229.3	+	3	3644	c.2935C>G	c.(2935-2937)Ctc>Gtc	p.L979V	SALL3_ENST00000575389.2_Missense_Mutation_p.L1112V|SALL3_ENST00000537592.2_Missense_Mutation_p.L1184V			Q9BXA9	SALL3_HUMAN	spalt-like transcription factor 3	1184					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(40)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		CCCCATGGCTCTCCTAGGGGG	0.602000													13	26					0	0	1	0	0
CCDC88C	440193	broad.mit.edu	37	14	91763765	91763765	+	Missense_Mutation	SNP	T	T	C			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr14:91763765T>C	ENST00000389857.6	-	22	3936	c.3850A>G	c.(3850-3852)Acc>Gcc	p.T1284A		NM_001080414.3	NP_001073883.2	Q9P219	DAPLE_HUMAN	coiled-coil domain containing 88C	1284					microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(6)|pancreas(1)|urinary_tract(1)	24		all_cancers(154;0.0468)				TTCAGTGAGGTTTTCAGCTCC	0.597000													17	8					0	0	1	0	0
SPTBN2	6712	broad.mit.edu	37	11	66476402	66476402	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr11:66476402C>T	ENST00000533211.1	-	11	1493	c.1162G>A	c.(1162-1164)Gag>Aag	p.E388K	SPTBN2_ENST00000309996.2_Missense_Mutation_p.E388K|SPTBN2_ENST00000529997.1_Missense_Mutation_p.E388K			O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	388					actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(15)|liver(1)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	74						AGCCGGCCCTCGCGGGGCGTG	0.617000													18	49					0	0	1	0	0
CXorf22	170063	broad.mit.edu	37	X	35966480	35966480	+	Silent	SNP	A	A	T			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chrX:35966480A>T	ENST00000297866.5	+	4	633	c.567A>T	c.(565-567)ccA>ccT	p.P189P		NM_152632.3	NP_689845.2	Q6ZTR5	CX022_HUMAN	chromosome X open reading frame 22	189										breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(3)	44						TCATTTTTCCAACTAGTGGTA	0.393000													30	25					0	0	1	0	0
PNLIP	5406	broad.mit.edu	37	10	118313298	118313298	+	Silent	SNP	C	C	T	rs150321250		TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr10:118313298C>T	ENST00000369221.2	+	6	547	c.519C>T	c.(517-519)caC>caT	p.H173H		NM_000936.2	NP_000927.1	P16233	LIPP_HUMAN	pancreatic lipase	173					lipid catabolic process|retinoid metabolic process|steroid metabolic process	extracellular region	retinyl-palmitate esterase activity|triglyceride lipase activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|liver(2)|lung(22)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	43				all cancers(201;0.0131)	Bentiromide(DB00522)|Orlistat(DB01083)	TGGGTGCCCACGCTGCTGGGG	0.522000													11	30					0	0	1	0	0
CDH17	1015	broad.mit.edu	37	8	95186135	95186135	+	Missense_Mutation	SNP	T	T	G			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr8:95186135T>G	ENST00000027335.3	-	7	797	c.673A>C	c.(673-675)Agt>Cgt	p.S225R	CDH17_ENST00000450165.2_Missense_Mutation_p.S225R|CDH17_ENST00000441892.2_Intron	NM_004063.3	NP_004054.3	Q12864	CAD17_HUMAN	cadherin 17, LI cadherin (liver-intestine)	225	Cadherin 2.					integral to membrane	calcium ion binding			NS(1)|endometrium(5)|kidney(3)|large_intestine(10)|lung(18)|ovary(6)|prostate(3)|skin(4)|stomach(2)	52	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)			GTGGTATCACTGAAGGAATTC	0.438000													19	84					0	0	1	0	0
IGHV7-81	28378	broad.mit.edu	37	14	107283086	107283086	+	RNA	SNP	G	G	T			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr14:107283086G>T	ENST00000390639.2	-	0	110																											GCTGCACCTGGGAGTAGGTAC	0.582000													21	105					6.44725e-10	7.28095e-10	1	1	0
SLC28A1	9154	broad.mit.edu	37	15	85486699	85486699	+	Silent	SNP	G	G	A	rs147715805		TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr15:85486699G>A	ENST00000394573.1	+	16	1807	c.1605G>A	c.(1603-1605)acG>acA	p.T535T	SLC28A1_ENST00000537624.1_Silent_p.T535T|SLC28A1_ENST00000538177.1_Silent_p.T369T|SLC28A1_ENST00000286749.3_Silent_p.T535T|SLC28A1_ENST00000537216.1_Intron	NM_004213.3	NP_004204.3	O00337	S28A1_HUMAN	solute carrier family 28 (concentrative nucleoside transporter), member 1	535					nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)	41			BRCA - Breast invasive adenocarcinoma(143;0.0587)			TCCTCACGACGTTTGCCCTCT	0.552000													13	28					0	0	1	0	0
PIWIL4	143689	broad.mit.edu	37	11	94331061	94331061	+	Missense_Mutation	SNP	A	A	C			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr11:94331061A>C	ENST00000299001.6	+	11	1571	c.1360A>C	c.(1360-1362)Ata>Cta	p.I454L	RP11-867G2.8_ENST00000537874.1_RNA|RP11-867G2.8_ENST00000536540.1_RNA	NM_152431.2	NP_689644.2	Q7Z3Z4	PIWL4_HUMAN	piwi-like RNA-mediated gene silencing 4	454					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|meiosis|multicellular organismal development|piRNA metabolic process|regulation of translation|spermatogenesis	nucleus|piP-body	piRNA binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(10)|prostate(1)|skin(1)|urinary_tract(2)	30		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				TTCAGAAAAAATATTAATGCA	0.388000													11	24					0	0	1	0	0
FAT1	2195	broad.mit.edu	37	4	187540460	187540460	+	Missense_Mutation	SNP	T	T	C			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr4:187540460T>C	ENST00000441802.2	-	10	7489	c.7280A>G	c.(7279-7281)tAt>tGt	p.Y2427C		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	2427	Cadherin 22.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						CAGAATGGAATACTGCAACTT	0.458000										HNSCC(5;0.00058)			14	34					0	0	1	0	0
ARF6	382	broad.mit.edu	37	14	50360513	50360513	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr14:50360513G>T	ENST00000298316.5	+	2	606	c.59G>T	c.(58-60)gGc>gTc	p.G20V		NM_001663.3	NP_001654.1	P62330	ARF6_HUMAN	ADP-ribosylation factor 6	20					cell adhesion|cellular component movement|cortical actin cytoskeleton organization|negative regulation of receptor-mediated endocytosis|positive regulation of actin filament polymerization|positive regulation of establishment of protein localization in plasma membrane|protein localization at cell surface|protein transport|regulation of dendritic spine development|regulation of filopodium assembly|regulation of Rac protein signal transduction|ruffle organization|small GTPase mediated signal transduction|vesicle-mediated transport	cell cortex|endosome membrane|filopodium membrane|Golgi apparatus|membrane fraction|ruffle	GTP binding|GTPase activity|thioesterase binding			endometrium(1)|kidney(1)|large_intestine(1)|ovary(1)	4	all_epithelial(31;0.000822)|Breast(41;0.0117)					CTCATGTTGGGCCTGGACGCG	0.597000													21	83					1.10513e-12	1.29261e-12	1	1	0
GALNT1	2589	broad.mit.edu	37	18	33243770	33243770	+	Silent	SNP	A	A	G			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr18:33243770A>G	ENST00000591081.1	+	2	409	c.318A>G	c.(316-318)taA>taG	p.*106*	GALNT1_ENST00000537549.1_Intron|GALNT1_ENST00000269195.5_Intron			Q10472	GALT1_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)	0					protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	extracellular region|Golgi cisterna membrane|integral to membrane|perinuclear region of cytoplasm	manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|ovary(4)|stomach(1)	21						TAGAAGGGTAAGTACTTACTG	0.323000													31	42					0	0	1	0	0
WDR60	55112	broad.mit.edu	37	7	158704239	158704239	+	Splice_Site	SNP	A	A	G			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr7:158704239A>G	ENST00000407559.3	+	12	1618		c.e12-1			NM_018051.4	NP_060521.4	Q8WVS4	WDR60_HUMAN	WD repeat domain 60											NS(3)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(2)|liver(4)|lung(16)|ovary(2)	35	Ovarian(565;0.152)	all_cancers(7;1.25e-09)|all_epithelial(9;0.000894)|all_hematologic(28;0.00603)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)|STAD - Stomach adenocarcinoma(7;0.18)		TTTATTTCAAAGGATGCGAAG	0.333000													4	20					0	0	1	0	0
GLRB	2743	broad.mit.edu	37	4	158057730	158057730	+	Missense_Mutation	SNP	A	A	C			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr4:158057730A>C	ENST00000264428.4	+	5	677	c.407A>C	c.(406-408)aAg>aCg	p.K136T	GLRB_ENST00000541722.1_Missense_Mutation_p.K136T|GLRB_ENST00000512619.1_Intron|GLRB_ENST00000509282.1_Missense_Mutation_p.K136T	NM_000824.4	NP_000815.1	P48167	GLRB_HUMAN	glycine receptor, beta	136					nervous system development|neuropeptide signaling pathway|startle response	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|protein binding|receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(11)|lung(6)|skin(5)|upper_aerodigestive_tract(1)	27	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.0564)|COAD - Colon adenocarcinoma(41;0.0642)|Kidney(143;0.0707)	Glycine(DB00145)	ACAATGTACAAGTGTTTATGG	0.398000													22	62					0	0	1	0	0
FMO4	2329	broad.mit.edu	37	1	171303840	171303840	+	Missense_Mutation	SNP	T	T	G			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr1:171303840T>G	ENST00000367749.3	+	8	1448	c.1118T>G	c.(1117-1119)cTt>cGt	p.L373R		NM_002022.1	NP_002013.1	P31512	FMO4_HUMAN	flavin containing monooxygenase 4	373					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(12)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	33	all_cancers(6;3.9e-08)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					CTTATCGGCCTTAAAGGATCC	0.438000													15	57					0	0	1	0	0
UGT2B28	54490	broad.mit.edu	37	4	70155439	70155439	+	Silent	SNP	G	G	T			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr4:70155439G>T	ENST00000335568.5	+	4	1061	c.1059G>T	c.(1057-1059)ctG>ctT	p.L353L	UGT2B28_ENST00000511240.1_Intron	NM_053039.1	NP_444267.1	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B28	353					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(16)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	31					Flunitrazepam(DB01544)	ATACTCGGCTGTATAAGTGGA	0.373000													18	77					1.02788e-11	1.18116e-11	1	1	0
TP53	7157	broad.mit.edu	37	17	7578442	7578442	+	Missense_Mutation	SNP	T	T	C	rs148924904		TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr17:7578442T>C	ENST00000420246.2	-	5	620	c.488A>G	c.(487-489)tAc>tGc	p.Y163C	TP53_ENST00000455263.2_Missense_Mutation_p.Y163C|TP53_ENST00000413465.2_Missense_Mutation_p.Y163C|TP53_ENST00000445888.2_Missense_Mutation_p.Y163C|TP53_ENST00000359597.4_Missense_Mutation_p.Y163C|TP53_ENST00000269305.4_Missense_Mutation_p.Y163C	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	163	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		Y -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|Y -> D (in sporadic cancers; somatic mutation).|Y -> F (in a sporadic cancer; somatic mutation).|Y -> H (in sporadic cancers; somatic mutation).|Y -> N (in sporadic cancers; somatic mutation).|Y -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Y163C(134)|p.Y70C(12)|p.Y31C(12)|p.0?(8)|p.Y163S(7)|p.V157_C176del20(1)|p.Y31S(1)|p.Y163fs*1(1)|p.Y70S(1)|p.Y163_Q165delYKQ(1)|p.P151_V173del23(1)|p.Y163fs*14(1)|p.S149fs*72(1)|p.A159_Q167delAMAIYKQSQ(1)|p.I162_Y163delIY(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGACTGCTTGTAGATGGCCAT	0.622000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			29	23					0	0	1	0	0
BEND2	139105	broad.mit.edu	37	X	18220055	18220055	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chrX:18220055G>A	ENST00000380033.4	-	6	1045	c.913C>T	c.(913-915)Cca>Tca	p.P305S	BEND2_ENST00000380030.3_Intron	NM_153346.4	NP_699177.2	Q8NDZ0	BEND2_HUMAN	BEN domain containing 2	305										NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(11)|liver(1)|lung(21)|ovary(3)|prostate(1)	49						GGTCTTTCTGGCATTTCTGTA	0.343000													9	16					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2717711	2717711	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr12:2717711G>T	ENST00000399655.1	+	27	3656	c.3391G>T	c.(3391-3393)Gac>Tac	p.D1131Y	CACNA1C_ENST00000399641.1_Missense_Mutation_p.D1131Y|CACNA1C_ENST00000399606.1_Missense_Mutation_p.D1151Y|CACNA1C_ENST00000347598.4_Missense_Mutation_p.D1151Y|CACNA1C_ENST00000344100.3_Missense_Mutation_p.D1131Y|CACNA1C_ENST00000327702.7_Missense_Mutation_p.D1131Y|CACNA1C_ENST00000480911.1_Missense_Mutation_p.D1131Y|CACNA1C_ENST00000399649.1_Missense_Mutation_p.D1131Y|CACNA1C_ENST00000399591.1_Missense_Mutation_p.D1131Y|CACNA1C_ENST00000399637.1_Missense_Mutation_p.D1131Y|CACNA1C_ENST00000399621.1_Missense_Mutation_p.D1131Y|CACNA1C_ENST00000399595.1_Missense_Mutation_p.D1131Y|CACNA1C_ENST00000399634.1_Missense_Mutation_p.D1131Y|CACNA1C_ENST00000399597.1_Missense_Mutation_p.D1131Y|CACNA1C_ENST00000399629.1_Missense_Mutation_p.D1131Y|CACNA1C_ENST00000399638.1_Missense_Mutation_p.D1131Y|CACNA1C_ENST00000399644.1_Missense_Mutation_p.D1131Y|CACNA1C_ENST00000399617.1_Missense_Mutation_p.D1131Y|CACNA1C_ENST00000399601.1_Missense_Mutation_p.D1131Y|CACNA1C_ENST00000406454.3_Missense_Mutation_p.D1131Y|CACNA1C_ENST00000335762.5_Missense_Mutation_p.D1156Y|CACNA1C_ENST00000402845.3_Missense_Mutation_p.D1131Y|CACNA1C_ENST00000399603.1_Missense_Mutation_p.D1131Y	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	1151	Dihydropyridine binding (By similarity).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	CCACACGGAAGACAAGGGCCC	0.552000													5	10					5.9392e-07	6.43004e-07	1	1	0
SLC6A2	6530	broad.mit.edu	37	16	55729260	55729260	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr16:55729260C>T	ENST00000379906.2	+	7	1348	c.1093C>T	c.(1093-1095)Ctt>Ttt	p.L365F	SLC6A2_ENST00000566163.1_Missense_Mutation_p.L320F|SLC6A2_ENST00000561820.1_Missense_Mutation_p.L365F|SLC6A2_ENST00000414754.3_Missense_Mutation_p.L365F|SLC6A2_ENST00000219833.8_Missense_Mutation_p.L365F|SLC6A2_ENST00000568943.1_Missense_Mutation_p.L365F|SLC6A2_ENST00000567238.1_Missense_Mutation_p.L260F	NM_001043.3	NP_001034.1	P23975	SC6A2_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 2	365					synaptic transmission	integral to plasma membrane|membrane fraction	norepinephrine:sodium symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(20)|ovary(3)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(1)	41				BRCA - Breast invasive adenocarcinoma(181;0.01)|Kidney(780;0.0267)	Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Atomoxetine(DB00289)|Bethanidine(DB00217)|Bupropion(DB01156)|Clomipramine(DB01242)|Cocaine(DB00907)|Debrisoquin(DB04840)|Desipramine(DB01151)|Diethylpropion(DB00937)|Doxepin(DB01142)|Duloxetine(DB00476)|Ergotamine(DB00696)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Imipramine(DB00458)|Maprotiline(DB00934)|Mazindol(DB00579)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Nefazodone(DB01149)|Norepinephrine(DB00368)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Protriptyline(DB00344)|Reboxetine(DB00234)|Sibutramine(DB01105)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)	CTTCTCCATCCTTGGTTACAT	0.587000													12	56					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158648221	158648221	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr1:158648221G>C	ENST00000368148.3	-	6	962	c.782C>G	c.(781-783)tCc>tGc	p.S261C	SPTA1_ENST00000368147.3_Missense_Mutation_p.S261C	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	261			S -> P (in EL2).		actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					TGCAGCATTGGACAGAGCTTT	0.438000													9	57					0	0	1	0	0
NF2	4771	broad.mit.edu	37	22	30051658	30051658	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr22:30051658C>T	ENST00000338641.4	+	6	1033	c.592C>T	c.(592-594)Cga>Tga	p.R198*	NF2_ENST00000397789.3_Nonsense_Mutation_p.R198*|NF2_ENST00000361452.4_Nonsense_Mutation_p.R157*|NF2_ENST00000413209.2_Intron|NF2_ENST00000347330.5_Intron|NF2_ENST00000403435.1_Nonsense_Mutation_p.R198*|NF2_ENST00000353887.4_Nonsense_Mutation_p.R115*|NF2_ENST00000361676.4_Nonsense_Mutation_p.R156*|NF2_ENST00000403999.3_Nonsense_Mutation_p.R198*|NF2_ENST00000361166.4_Nonsense_Mutation_p.R198*|NF2_ENST00000334961.7_Nonsense_Mutation_p.R115*	NM_000268.3|NM_016418.5|NM_181832.2	NP_000259.1|NP_057502.2|NP_861970.1	P35240	MERL_HUMAN	neurofibromin 2 (merlin)	198	FERM.				actin cytoskeleton organization|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of cell-cell adhesion|negative regulation of cell-matrix adhesion|negative regulation of DNA replication|negative regulation of tyrosine phosphorylation of Stat3 protein|negative regulation of tyrosine phosphorylation of Stat5 protein|positive regulation of stress fiber assembly|regulation of hippo signaling cascade|Schwann cell proliferation	cytoskeleton|early endosome|extrinsic to membrane|filopodium membrane|nucleolus|perinuclear region of cytoplasm|ruffle membrane	cytoskeletal protein binding|protein binding	p.?(3)|p.R198*(3)|p.R198fs*4(1)		NS(1)|bone(2)|breast(5)|central_nervous_system(21)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(17)|large_intestine(9)|liver(1)|lung(9)|meninges(372)|ovary(2)|pituitary(1)|pleura(9)|prostate(1)|skin(7)|soft_tissue(303)|stomach(2)|thyroid(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	776						GCACCGAGGCCGAGCCAGGTG	0.398000			"""D, Mis, N, F, S, O"""		"""meningioma, acoustic neuroma, renal """	"""meningioma, acoustic neuroma"""			Neurofibromatosis, type 2				16	23					0	0	1	0	0
ERBB3	2065	broad.mit.edu	37	12	56490841	56490841	+	Missense_Mutation	SNP	A	A	T			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr12:56490841A>T	ENST00000267101.3	+	20	2727	c.2287A>T	c.(2287-2289)Att>Ttt	p.I763F	ERBB3_ENST00000553131.1_Missense_Mutation_p.I4F|ERBB3_ENST00000450146.2_Missense_Mutation_p.I120F|ERBB3_ENST00000415288.2_Missense_Mutation_p.I704F	NM_001982.3	NP_001973.2	P21860	ERBB3_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3	763	Protein kinase.				cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(2)|lung(3)|ovary(1)|skin(1)|stomach(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			TATGCTGGCCATTGGCAGCCT	0.537000													13	50					0	0	1	0	0
CARD11	84433	broad.mit.edu	37	7	2969673	2969673	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr7:2969673G>A	ENST00000396946.4	-	12	2009	c.1606C>T	c.(1606-1608)Cct>Tct	p.P536S		NM_032415.4	NP_115791.3	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	536					positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(62)|kidney(11)|large_intestine(13)|lung(31)|ovary(4)|prostate(5)|skin(7)|upper_aerodigestive_tract(2)	150		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		CAGGAGCTAGGGCTGGCGTCC	0.627000			Mis		DLBCL								12	44					0	0	1	0	0
MICAL1	64780	broad.mit.edu	37	6	109770680	109770680	+	Missense_Mutation	SNP	C	C	A	rs143598372		TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr6:109770680C>A	ENST00000368952.4	-	11	1786	c.1496G>T	c.(1495-1497)cGa>cTa	p.R499L	MICAL1_ENST00000358577.3_Missense_Mutation_p.R394L|MICAL1_ENST00000358807.3_Missense_Mutation_p.R480L			Q8TDZ2	MICA1_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 1	480					cytoskeleton organization|signal transduction	cytoplasm|intermediate filament	SH3 domain binding|zinc ion binding			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|liver(1)|lung(7)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	40		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0142)|all cancers(137;0.0197)|OV - Ovarian serous cystadenocarcinoma(136;0.0233)|BRCA - Breast invasive adenocarcinoma(108;0.0574)		ATACAGGTCTCGTACCTAAGG	0.617000													15	67					6.31663e-08	6.9536e-08	1	1	0
KIAA0556	23247	broad.mit.edu	37	16	27751397	27751397	+	Silent	SNP	C	C	T			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr16:27751397C>T	ENST00000261588.4	+	15	1798	c.1779C>T	c.(1777-1779)taC>taT	p.Y593Y		NM_015202.2	NP_056017.2	O60303	K0556_HUMAN	KIAA0556	593										breast(4)|endometrium(7)|kidney(8)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	76						TGAAGCTTTACGTCAACAGAA	0.438000													15	74					0	0	1	0	0
KCTD19	146212	broad.mit.edu	37	16	67337093	67337093	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr16:67337093G>A	ENST00000304372.5	-	4	654	c.599C>T	c.(598-600)aCg>aTg	p.T200M	KCTD19_ENST00000562860.1_5'UTR	NM_001100915.1	NP_001094385.1	Q17RG1	KCD19_HUMAN	potassium channel tetramerization domain containing 19	200						voltage-gated potassium channel complex	voltage-gated potassium channel activity	p.T200M(1)		endometrium(3)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(3)	23		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)		GAGGGCCACCGTCTCAGCCAG	0.612000													9	20					0	0	1	0	0
REXO1	57455	broad.mit.edu	37	19	1821533	1821533	+	Silent	SNP	G	G	A			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr19:1821533G>A	ENST00000170168.4	-	5	2473	c.2379C>T	c.(2377-2379)caC>caT	p.H793H		NM_020695.3	NP_065746.3	Q8N1G1	REXO1_HUMAN	REX1, RNA exonuclease 1 homolog (S. cerevisiae)	793						nucleus	exonuclease activity|nucleic acid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	16		Ovarian(11;1.78e-06)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGGATGGACTGTGGGCGATTC	0.647000													24	91					0	0	1	0	0
OLFM3	118427	broad.mit.edu	37	1	102296366	102296366	+	Silent	SNP	C	C	T			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr1:102296366C>T	ENST00000370103.4	-	3	447	c.234G>A	c.(232-234)caG>caA	p.Q78Q	OLFM3_ENST00000338858.5_Silent_p.Q98Q|OLFM3_ENST00000359814.3_Silent_p.Q98Q|OLFM3_ENST00000462354.1_5'UTR|OLFM3_ENST00000536598.1_Silent_p.Q3Q	NM_058170.2	NP_477518.2	Q96PB7	NOE3_HUMAN	olfactomedin 3	98						extracellular region				breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(24)|ovary(3)|prostate(1)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(2)	43		all_epithelial(167;1.87e-06)|all_lung(203;8.12e-05)|Lung NSC(277;0.000189)		all cancers(265;0.0843)|Epithelial(280;0.0921)|COAD - Colon adenocarcinoma(174;0.145)		CTTCAATAGACTGGGACATGT	0.353000													9	46					0	0	1	0	0
CHAD	1101	broad.mit.edu	37	17	48545748	48545748	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr17:48545748G>A	ENST00000508540.1	-	1	579	c.427C>T	c.(427-429)Ctc>Ttc	p.L143F	ACSF2_ENST00000300441.4_Intron|ACSF2_ENST00000504392.1_Intron|ACSF2_ENST00000427954.2_Intron|CHAD_ENST00000258969.4_Missense_Mutation_p.L143F|ACSF2_ENST00000506085.1_3'UTR|ACSF2_ENST00000502667.1_Intron|ACSF2_ENST00000541920.1_Intron	NM_001267.2	NP_001258.2	O15335	CHAD_HUMAN	chondroadherin	143					regulation of cell growth	proteinaceous extracellular matrix	extracellular matrix structural constituent			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(2)|ovary(2)	15	Breast(11;1.93e-18)		BRCA - Breast invasive adenocarcinoma(22;1.55e-09)			AGCGGGGAGAGCAACCCCCGG	0.632000													17	54					0	0	1	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96593000	96593000	+	Missense_Mutation	SNP	A	A	G	rs111976783		TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr2:96593000A>G	ENST00000456556.1	-	28	1985	c.1901T>C	c.(1900-1902)aTa>aCa	p.I634T						ankyrin repeat domain 36C									p.I634T(1)		breast(1)|endometrium(8)|kidney(5)|lung(4)	18						TTCTGTGGCTATATTTGAAAC	0.338000													3	36					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77618518	77618518	+	Missense_Mutation	SNP	A	A	T			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr8:77618518A>T	ENST00000521891.2	+	2	2643	c.2195A>T	c.(2194-2196)aAt>aTt	p.N732I	ZFHX4_ENST00000050961.6_Missense_Mutation_p.N732I|ZFHX4_ENST00000518282.1_Missense_Mutation_p.N732I|ZFHX4_ENST00000455469.2_Missense_Mutation_p.N732I|ZFHX4_ENST00000517683.1_Intron	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	732						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AATCTCCAAAATGGCAATGGT	0.517000										HNSCC(33;0.089)			16	28					0	0	1	0	0
ASPRV1	151516	broad.mit.edu	37	2	70188289	70188289	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr2:70188289C>A	ENST00000320256.4	-	1	1108	c.532G>T	c.(532-534)Gcc>Tcc	p.A178S		NM_152792.2	NP_690005.2	Q53RT3	APRV1_HUMAN	aspartic peptidase, retroviral-like 1	178					protein maturation by peptide bond cleavage|skin development		aspartic-type endopeptidase activity			endometrium(3)|large_intestine(4)|lung(6)|ovary(1)	14						TGGCTGGGGGCAGCCCCAGGG	0.587000													19	40					1.33834e-09	1.48578e-09	1	1	0
DCUN1D3	123879	broad.mit.edu	37	16	20871437	20871437	+	Missense_Mutation	SNP	G	G	A	rs149680095		TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr16:20871437G>A	ENST00000324344.3	-	3	971	c.686C>T	c.(685-687)aCa>aTa	p.T229I	DCUN1D3_ENST00000563934.1_Missense_Mutation_p.T229I|ERI2_ENST00000564349.1_Intron	NM_173475.2	NP_775746.1	Q8IWE4	DCNL3_HUMAN	DCN1, defective in cullin neddylation 1, domain containing 3	229	DCUN1.				negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|positive regulation of apoptosis|response to gamma radiation|response to UV-C	perinuclear region of cytoplasm				NS(2)|breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(3)|ovary(2)	14				GBM - Glioblastoma multiforme(48;0.249)		GGGGTTCTCTGTTAGGAAGTT	0.517000													29	104					0	0	1	0	0
HNRNPR	10236	broad.mit.edu	37	1	23637080	23637080	+	Missense_Mutation	SNP	T	T	A			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr1:23637080T>A	ENST00000478691.1	-	10	1746	c.1475A>T	c.(1474-1476)aAc>aTc	p.N492I	HNRNPR_ENST00000302271.6_Missense_Mutation_p.N590I|HNRNPR_ENST00000426846.2_Missense_Mutation_p.N430I|HNRNPR_ENST00000606561.1_Missense_Mutation_p.N451I|HNRNPR_ENST00000374612.1_Missense_Mutation_p.N590I|HNRNPR_ENST00000427764.2_Missense_Mutation_p.N552I|HNRNPR_ENST00000374616.3_Missense_Mutation_p.N593I|HNRNPR_ENST00000476660.1_5'UTR	NM_001102397.1|NM_001102399.1	NP_001095867.1|NP_001095869.1	O43390	HNRPR_HUMAN	heterogeneous nuclear ribonucleoprotein R	590	3 X 11 AA approximate repeats of D-D-Y-Y- G-Y-D-Y-H-D-Y.|RNA-binding RGG-box.					catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00394)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;6.83e-27)|Colorectal(126;6.01e-08)|COAD - Colon adenocarcinoma(152;3.32e-06)|GBM - Glioblastoma multiforme(114;6.69e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|KIRC - Kidney renal clear cell carcinoma(1967;0.00357)|STAD - Stomach adenocarcinoma(196;0.0131)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0875)|LUSC - Lung squamous cell carcinoma(448;0.19)		GTTCTGTTGGTTGTTGGTCTG	0.522000													52	137					0	0	1	0	0
KIF25	3834	broad.mit.edu	37	6	168440845	168440845	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr6:168440845C>T	ENST00000443060.2	+	7	986	c.595C>T	c.(595-597)Cac>Tac	p.H199Y	KIF25_ENST00000351261.3_Missense_Mutation_p.H199Y|KIF25_ENST00000354419.2_Missense_Mutation_p.H199Y			Q9UIL4	KIF25_HUMAN	kinesin family member 25	199	Kinesin-motor.				microtubule-based movement|mitotic sister chromatid segregation	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			NS(2)|breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	29		Breast(66;1.07e-05)|Ovarian(120;0.0728)		Epithelial(4;7.7e-30)|OV - Ovarian serous cystadenocarcinoma(33;5.82e-22)|BRCA - Breast invasive adenocarcinoma(4;1.38e-10)|GBM - Glioblastoma multiforme(31;0.000756)		CTCCAGGTCTCACCTGATAAT	0.557000													15	29					0	0	1	0	0
KMT2E	55904	broad.mit.edu	37	7	104717552	104717552	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr7:104717552C>T	ENST00000334877.4	+	10	1445	c.911C>T	c.(910-912)gCt>gTt	p.A304V	KMT2E_ENST00000334914.7_5'UTR|KMT2E_ENST00000476671.1_Missense_Mutation_p.A304V|KMT2E_ENST00000311117.3_Missense_Mutation_p.A304V|KMT2E_ENST00000257745.4_Missense_Mutation_p.A304V					lysine (K)-specific methyltransferase 2E																		CAAAGAATAGCTCTGAGATTA	0.388000													6	29					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82764191	82764191	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr7:82764191G>C	ENST00000423517.2	-	3	3012	c.2675C>G	c.(2674-2676)cCt>cGt	p.P892R	PCLO_ENST00000333891.8_Missense_Mutation_p.P892R	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	838	Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						GGACTGTTGAGGTGTGGGGAC	0.532000													39	182					0	0	1	0	0
LRP1	4035	broad.mit.edu	37	12	57573659	57573659	+	Silent	SNP	C	C	A			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr12:57573659C>A	ENST00000243077.3	+	30	5527	c.5061C>A	c.(5059-5061)gcC>gcA	p.A1687A		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	1687					aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	TCAATGTGGCCCGGCTGGATG	0.612000													25	84					1.5548e-18	1.83494e-18	1	1	0
CPT1A	1374	broad.mit.edu	37	11	68552417	68552417	+	Silent	SNP	G	G	A			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr11:68552417G>A	ENST00000265641.5	-	10	1183	c.1029C>T	c.(1027-1029)ttC>ttT	p.F343F	CPT1A_ENST00000376618.2_Silent_p.F343F|CPT1A_ENST00000539743.1_Silent_p.F343F|CPT1A_ENST00000540367.1_Silent_p.F343F	NM_001876.3	NP_001867.2	P50416	CPT1A_HUMAN	carnitine palmitoyltransferase 1A (liver)	343			F -> V (in CPT1AD).		carnitine shuttle|fatty acid beta-oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			NS(2)|breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|liver(1)|lung(17)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42	Esophageal squamous(3;3.28e-14)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.142)		L-Carnitine(DB00583)|Perhexiline(DB01074)	GCCAGACCTTGAAGTAGCGTC	0.592000													14	358					0	0	1	0	0
CERS2	29956	broad.mit.edu	37	1	150939941	150939941	+	Missense_Mutation	SNP	T	T	C			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr1:150939941T>C	ENST00000271688.6	-	7	925	c.539A>G	c.(538-540)tAt>tGt	p.Y180C	CERS2_ENST00000368954.5_Missense_Mutation_p.Y180C|CERS2_ENST00000345896.4_5'UTR|CERS2_ENST00000561294.1_Missense_Mutation_p.Y171C	NM_181746.3	NP_859530.1	Q96G23	CERS2_HUMAN	ceramide synthase 2	180	TLC.					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity										GTAGTACCAATACTGGGAAGG	0.527000													15	46					0	0	1	0	0
RSBN1	54665	broad.mit.edu	37	1	114308737	114308737	+	Silent	SNP	T	T	A			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr1:114308737T>A	ENST00000261441.5	-	7	2337	c.2274A>T	c.(2272-2274)tcA>tcT	p.S758S		NM_018364.3	NP_060834.2	Q5VWQ0	RSBN1_HUMAN	round spermatid basic protein 1	758						nucleus				breast(1)|endometrium(2)|large_intestine(4)|lung(16)|ovary(1)|prostate(3)|urinary_tract(2)	29	Lung SC(450;0.184)	all_cancers(81;3.78e-08)|all_epithelial(167;5.56e-08)|all_lung(203;6.97e-06)|Lung NSC(69;1.18e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTGGGAAAGATGATGAAGCAG	0.418000													29	82					0	0	1	0	0
OR10H3	26532	broad.mit.edu	37	19	15852977	15852977	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr19:15852977C>G	ENST00000305892.1	+	1	775	c.775C>G	c.(775-777)Ctt>Gtt	p.L259V		NM_013938.1	NP_039226.1	O60404	O10H3_HUMAN	olfactory receptor, family 10, subfamily H, member 3	259					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(2)|endometrium(1)|kidney(2)|large_intestine(1)|liver(1)|lung(6)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	17						TTTTGCCTCCCTTATCTACCT	0.502000													26	94					0	0	1	0	0
FGFR3	2261	broad.mit.edu	37	4	1808391	1808391	+	Missense_Mutation	SNP	G	G	A	rs17882190	byFrequency	TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr4:1808391G>A	ENST00000340107.4	+	16	2411	c.2155G>A	c.(2155-2157)Gcc>Acc	p.A719T	FGFR3_ENST00000440486.2_Missense_Mutation_p.A717T|FGFR3_ENST00000352904.1_Missense_Mutation_p.A605T|FGFR3_ENST00000412135.2_Missense_Mutation_p.A605T|FGFR3_ENST00000260795.2_Missense_Mutation_p.A717T|FGFR3_ENST00000481110.2_Missense_Mutation_p.R694H	NM_001163213.1	NP_001156685.1	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3	717	Protein kinase.				bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding			NS(1)|central_nervous_system(5)|cervix(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(40)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(9)|skin(339)|soft_tissue(4)|testis(2)|upper_aerodigestive_tract(58)|urinary_tract(2607)	3091		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	GGACAAGCCCGCCAACTGCAC	0.692000		1	"""Mis, T"""	"""IGH@, ETV6"""	"""bladder, MM, T-cell lymphoma"""		"""Hypochondroplasia, Thanatophoric dysplasia"""		Saethre-Chotzen syndrome;Muenke syndrome				3	32					0	0	1	0	0
GRM8	2918	broad.mit.edu	37	7	126746673	126746673	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr7:126746673G>C	ENST00000339582.2	-	3	1412	c.604C>G	c.(604-606)Caa>Gaa	p.Q202E	GRM8_ENST00000405249.1_Missense_Mutation_p.Q202E|GRM8_ENST00000358373.3_Missense_Mutation_p.Q202E|GRM8_ENST00000480995.1_5'UTR|GRM8_ENST00000444921.2_Missense_Mutation_p.Q202E			O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8	202					negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(16)|lung(62)|ovary(5)|pancreas(1)|prostate(1)|skin(14)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(4)	125		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	GCTTGGGCTTGGTAGGAGTCA	0.512000										HNSCC(24;0.065)			11	37					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	186063420	186063420	+	Silent	SNP	T	T	C			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr1:186063420T>C	ENST00000271588.4	+	67	10438	c.10209T>C	c.(10207-10209)gcT>gcC	p.A3403A	HMCN1_ENST00000367492.2_Silent_p.A3403A	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	3403	Ig-like C2-type 32.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						TTGTGAGAGCTCAGGTGTCTG	0.388000													9	39					0	0	1	0	0
LEPR	3953	broad.mit.edu	37	1	66088607	66088607	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr1:66088607G>A	ENST00000349533.6	+	19	2801	c.2616G>A	c.(2614-2616)tgG>tgA	p.W872*	LEPR_ENST00000371060.3_Nonsense_Mutation_p.W872*|LEPR_ENST00000371058.1_Nonsense_Mutation_p.W872*|LEPR_ENST00000371059.3_Nonsense_Mutation_p.W872*|LEPR_ENST00000344610.8_Nonsense_Mutation_p.W872*|LEPR_ENST00000406510.3_Intron	NM_002303.5	NP_002294.2	P48357	LEPR_HUMAN	leptin receptor	872					energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(22)|skin(2)	36				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		AGCTATTTTGGGAAGATGTTC	0.348000													9	21					0	0	1	0	0
RBM14	10432	broad.mit.edu	37	11	66394099	66394099	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr11:66394099G>A	ENST00000310137.4	+	3	2109	c.1970G>A	c.(1969-1971)cGg>cAg	p.R657Q	RBM14-RBM4_ENST00000412278.2_Intron|RBM14_ENST00000393979.3_3'UTR|RBM4_ENST00000514361.3_Intron|RBM4_ENST00000503028.2_Intron|RBM14-RBM4_ENST00000500635.2_Intron	NM_006328.3	NP_006319.1	Q96PK6	RBM14_HUMAN	RNA binding motif protein 14	657					DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|histone deacetylation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus	mediator complex|ribonucleoprotein complex|transcription factor complex	ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|protein binding, bridging|RNA binding|RNA polymerase II transcription cofactor activity		RBM14/PACS1(2)	breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(3)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	17						GATTACCTGCGGGCGGCTCAG	0.607000													10	9					0	0	1	0	0
GTPBP4	23560	broad.mit.edu	37	10	1056448	1056448	+	Silent	SNP	A	A	T			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr10:1056448A>T	ENST00000360803.4	+	13	1414	c.1332A>T	c.(1330-1332)ccA>ccT	p.P444P	GTPBP4_ENST00000545048.1_Silent_p.P397P|GTPBP4_ENST00000538293.1_Silent_p.P328P|GTPBP4_ENST00000491635.1_3'UTR	NM_012341.2	NP_036473.2	Q9BZE4	NOG1_HUMAN	GTP binding protein 4	444					negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of cell-cell adhesion|negative regulation of collagen binding|negative regulation of DNA replication|negative regulation of protein ubiquitination|protein stabilization|regulation of cyclin-dependent protein kinase activity|ribosome biogenesis	nucleolus|perinuclear region of cytoplasm	GTP binding|GTPase activity|protein binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(11)|ovary(1)|prostate(2)|skin(1)	21		all_epithelial(10;0.107)|Colorectal(49;0.14)	OV - Ovarian serous cystadenocarcinoma(33;0.0814)	Epithelial(11;0.0513)|all cancers(11;0.135)|OV - Ovarian serous cystadenocarcinoma(14;0.173)		ATATTGATCCAGCCATCATGA	0.353000													7	53					0	0	1	0	0
TECRL	253017	broad.mit.edu	37	4	65274925	65274925	+	Missense_Mutation	SNP	T	T	A			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr4:65274925T>A	ENST00000381210.3	-	1	255	c.145A>T	c.(145-147)Act>Tct	p.T49S	TECRL_ENST00000507440.1_Missense_Mutation_p.T49S	NM_001010874.4	NP_001010874.2	Q5HYJ1	TECRL_HUMAN	trans-2,3-enoyl-CoA reductase-like	49					lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors			endometrium(2)|kidney(5)|large_intestine(7)|lung(30)|prostate(1)|skin(1)|stomach(1)	47						ACTGCTGGAGTTGGTCTTAGA	0.368000													17	29					0	0	1	0	0
SCGB1D4	404552	broad.mit.edu	37	11	62065047	62065047	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr11:62065047C>A	ENST00000358585.1	-	2	192	c.139G>T	c.(139-141)Gcc>Tcc	p.A47S		NM_206998.1	NP_996881.1	Q6XE38	SG1D4_HUMAN	secretoglobin, family 1D, member 4	47						extracellular region	binding			lung(1)|prostate(1)	2						TTAAGTTTGGCAACTTGGAGG	0.448000													48	119					1.48734e-19	1.77128e-19	1	1	0
BTBD3	22903	broad.mit.edu	37	20	11899106	11899106	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr20:11899106G>T	ENST00000405977.1	+	2	808	c.183G>T	c.(181-183)aaG>aaT	p.K61N	BTBD3_ENST00000378226.2_Missense_Mutation_p.K61N|BTBD3_ENST00000399006.2_5'UTR|RP4-742J24.2_ENST00000439529.1_RNA|BTBD3_ENST00000254977.3_5'UTR			Q9Y2F9	BTBD3_HUMAN	BTB (POZ) domain containing 3	61								p.K61K(1)		breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(18)|ovary(3)|skin(2)	34						AAAAGAAGAAGATGGCTGCTG	0.448000													18	139					2.35188e-11	2.6791e-11	1	1	0
ZNF540	163255	broad.mit.edu	37	19	38104133	38104133	+	Missense_Mutation	SNP	A	A	G			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr19:38104133A>G	ENST00000592533.1	+	5	2284	c.1952A>G	c.(1951-1953)tAt>tGt	p.Y651C	ZNF540_ENST00000316433.4_Missense_Mutation_p.Y651C|ZNF540_ENST00000343599.5_Missense_Mutation_p.Y651C|ZNF540_ENST00000589117.1_Missense_Mutation_p.Y619C	NM_152606.4	NP_689819.1			zinc finger protein 540											breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(13)|lung(8)|skin(1)	28			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TCACATCTTTATCAACATCAG	0.318000													6	30					0	0	1	0	0
RNF130	55819	broad.mit.edu	37	5	179405210	179405210	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr5:179405210G>C	ENST00000522208.2	-	5	859	c.841C>G	c.(841-843)Ccc>Gcc	p.P281A	RNF130_ENST00000521389.1_Missense_Mutation_p.P281A|RNF130_ENST00000261947.4_Missense_Mutation_p.P281A			Q86XS8	GOLI_HUMAN	ring finger protein 130	281					apoptosis	cytoplasm|integral to membrane|nucleus	ubiquitin-protein ligase activity|zinc ion binding			breast(2)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|upper_aerodigestive_tract(2)	17	all_cancers(89;5.49e-05)|all_epithelial(37;1.94e-05)|Renal(175;0.000159)|Lung NSC(126;0.00118)|all_lung(126;0.00212)	all_cancers(40;0.0294)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TACTTGCAGGGGAGAATTCGG	0.413000													13	53					0	0	1	0	0
GLDN	342035	broad.mit.edu	37	15	51687166	51687166	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr15:51687166G>A	ENST00000335449.6	+	5	732	c.676G>A	c.(676-678)Gtg>Atg	p.V226M	GLDN_ENST00000396399.2_Missense_Mutation_p.V102M	NM_181789.2	NP_861454.2	Q6ZMI3	GLDN_HUMAN	gliomedin	226					cell differentiation|nervous system development	collagen|integral to membrane|plasma membrane				central_nervous_system(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	19				all cancers(107;0.00194)|GBM - Glioblastoma multiforme(94;0.00942)		GTCCAACGACGTGCTCCTGGC	0.587000													6	15					0	0	1	0	0
OGG1	4968	broad.mit.edu	37	3	9792851	9792851	+	Silent	SNP	C	C	T			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr3:9792851C>T	ENST00000302036.7	+	2	703	c.360C>T	c.(358-360)ttC>ttT	p.F120F	OGG1_ENST00000349503.5_Silent_p.F120F|OGG1_ENST00000339511.5_Silent_p.F120F|OGG1_ENST00000302003.7_Silent_p.F120F|OGG1_ENST00000383826.5_Silent_p.F120F|OGG1_ENST00000449570.2_Silent_p.F120F|OGG1_ENST00000344629.7_Silent_p.F120F|OGG1_ENST00000302008.8_Silent_p.F120F	NM_016821.2	NP_058214.1	O15527	OGG1_HUMAN	8-oxoguanine DNA glycosylase	120					depurination|nucleotide-excision repair|regulation of protein import into nucleus, translocation|regulation of transcription, DNA-dependent|response to oxidative stress|response to radiation	mitochondrion|nuclear matrix|nuclear speck	damaged DNA binding|endonuclease activity|oxidized purine base lesion DNA N-glycosylase activity|protein binding			kidney(2)|large_intestine(2)|lung(2)|skin(1)|urinary_tract(1)	8	Medulloblastoma(99;0.227)					ACTCCCACTTCCAAGAGGTGG	0.547000								Base excision repair (BER), DNA glycosylases					15	14					0	0	1	0	0
SPG11	80208	broad.mit.edu	37	15	44878014	44878014	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr15:44878014C>A	ENST00000261866.7	-	29	4957	c.4941G>T	c.(4939-4941)caG>caT	p.Q1647H	SPG11_ENST00000558319.1_Missense_Mutation_p.Q1647H|SPG11_ENST00000535302.2_Missense_Mutation_p.Q1647H|SPG11_ENST00000558253.1_5'UTR|SPG11_ENST00000427534.2_Missense_Mutation_p.Q1647H	NM_025137.3	NP_079413.3	Q96JI7	SPTCS_HUMAN	spastic paraplegia 11 (autosomal recessive)	1647					cell death	cytosol|integral to membrane|nucleus	protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	72		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		CCTTCAAAATCTGGCAAAGGA	0.358000													26	69					1.17739e-12	1.36494e-12	1	1	0
NEU2	4759	broad.mit.edu	37	2	233898940	233898940	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr2:233898940C>A	ENST00000233840.3	+	2	316	c.316C>A	c.(316-318)Cct>Act	p.P106T		NM_005383.2	NP_005374.2	Q9Y3R4	NEUR2_HUMAN	sialidase 2 (cytosolic sialidase)	106							exo-alpha-sialidase activity			endometrium(3)|large_intestine(2)|lung(10)|skin(2)|urinary_tract(1)	18		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0271)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0839)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000311)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)|GBM - Glioblastoma multiforme(43;0.0488)		CATTGCCATCCCTGGGCAAGT	0.647000													20	50					0.000132079	0.000138419	1	1	0
CABS1	85438	broad.mit.edu	37	4	71201289	71201289	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr4:71201289C>T	ENST00000273936.4	+	1	592	c.533C>T	c.(532-534)gCc>gTc	p.A178V		NM_033122.3	NP_149113.3	Q96KC9	CABS1_HUMAN	calcium-binding protein, spermatid-specific 1	178						flagellum	calcium ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(4)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						GACGCTCCTGCCTTTCCACGT	0.468000													9	33					0	0	1	0	0
MST1L	11223	broad.mit.edu	37	1	17084510	17084510	+	RNA	SNP	G	G	A	rs61769731	by1000genomes	TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr1:17084510G>A	ENST00000455405.2	-	0	379																		p.L525L(2)|p.L530L(2)									ACCCGCTGTAGGCCTGGCTCT	0.577000													3	30					0	0	1	0	0
CTGF	1490	broad.mit.edu	37	6	132270603	132270603	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr6:132270603C>A	ENST00000367976.3	-	5	1051	c.851G>T	c.(850-852)tGt>tTt	p.C284F		NM_001901.2	NP_001892.1	P29279	CTGF_HUMAN	connective tissue growth factor	284	CTCK.|Heparin-binding.				cellular lipid metabolic process|DNA replication|epidermis development|regulation of cell growth|response to wounding	plasma membrane|proteinaceous extracellular matrix	heparin binding|insulin-like growth factor binding			breast(1)|endometrium(6)|kidney(1)|large_intestine(1)|lung(3)|prostate(1)	13	Breast(56;0.0602)			GBM - Glioblastoma multiforme(226;0.015)|OV - Ovarian serous cystadenocarcinoma(155;0.0169)		ACATACTCCACAGAATTTAGC	0.527000													61	183					1.08141e-31	1.29967e-31	1	1	0
FCN3	8547	broad.mit.edu	37	1	27695795	27695795	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr1:27695795C>T	ENST00000270879.4	-	8	837	c.832G>A	c.(832-834)Ggc>Agc	p.G278S	FCN3_ENST00000354982.2_Missense_Mutation_p.G267S	NM_003665.2	NP_003656.2	O75636	FCN3_HUMAN	ficolin (collagen/fibrinogen domain containing) 3	278	Fibrinogen C-terminal.				complement activation, lectin pathway|signal transduction	collagen|extracellular space	receptor binding|sugar binding			endometrium(2)|kidney(2)|large_intestine(1)|lung(1)|urinary_tract(1)	7		all_lung(284;1.6e-05)|Lung NSC(340;2.92e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.0175)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;1.42e-27)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00128)|KIRC - Kidney renal clear cell carcinoma(1967;0.00155)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		CAGTCAATGCCATATTTGTGG	0.577000													18	75					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128485310	128485310	+	Splice_Site	SNP	G	G	A			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr7:128485310G>A	ENST00000325888.8	+	21	4051		c.e21+1		FLNC_ENST00000346177.6_Splice_Site	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma						cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						GAGCCACACGGTGAGTGGACA	0.622000													3	17					0	0	1	0	0
ALKBH2	121642	broad.mit.edu	37	12	109530356	109530356	+	Missense_Mutation	SNP	T	T	A			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr12:109530356T>A	ENST00000429722.2	-	2	599	c.236A>T	c.(235-237)gAt>gTt	p.D79V	ALKBH2_ENST00000440112.2_Missense_Mutation_p.D79V|ALKBH2_ENST00000343075.3_Missense_Mutation_p.D79V	NM_001145374.1	NP_001138846.1	Q6NS38	ALKB2_HUMAN	alkB, alkylation repair homolog 2 (E. coli)	79					DNA dealkylation involved in DNA repair|oxidative DNA demethylation	nucleoplasm	cytosine C-5 DNA demethylase activity|damaged DNA binding|DNA-N1-methyladenine dioxygenase activity|ferrous iron binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			endometrium(1)|kidney(3)|large_intestine(1)|lung(3)	8					Vitamin C(DB00126)	GAAAATCTCATCTGCCTCAGC	0.522000								Direct reversal of damage					29	48					0	0	1	0	0
MROH5	389690	broad.mit.edu	37	8	142481168	142481168	+	RNA	SNP	T	T	A			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr8:142481168T>A	ENST00000430863.1	-	0	2073					NM_207414.2	NP_997297.2			maestro heat-like repeat family member 5																		TTGTGGCACATCAAGAGCTGG	0.597000													30	110					0	0	1	0	0
KMT2E	55904	broad.mit.edu	37	7	104717551	104717551	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr7:104717551G>T	ENST00000334877.4	+	10	1444	c.910G>T	c.(910-912)Gct>Tct	p.A304S	KMT2E_ENST00000334914.7_5'UTR|KMT2E_ENST00000476671.1_Missense_Mutation_p.A304S|KMT2E_ENST00000311117.3_Missense_Mutation_p.A304S|KMT2E_ENST00000257745.4_Missense_Mutation_p.A304S					lysine (K)-specific methyltransferase 2E																		ACAAAGAATAGCTCTGAGATT	0.388000													6	28					5.9392e-07	6.43004e-07	1	1	0
CSRP2BP	57325	broad.mit.edu	37	20	18143347	18143347	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr20:18143347G>A	ENST00000278816.2	+	7	2079	c.1429G>A	c.(1429-1431)Gct>Act	p.A477T	CSRP2BP_ENST00000435364.2_Missense_Mutation_p.A477T|CSRP2BP_ENST00000489634.2_Missense_Mutation_p.A349T|CSRP2BP_ENST00000377681.2_Missense_Mutation_p.A476T			Q9H8E8	CSR2B_HUMAN	CSRP2 binding protein	477					histone H3 acetylation	Ada2/Gcn5/Ada3 transcription activator complex|cytoplasm	LIM domain binding|N-acetyltransferase activity			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(12)|ovary(2)|prostate(3)|skin(1)|stomach(1)	34						GAGGCTGGAAGCTTGTCCCGG	0.517000													21	60					0	0	1	0	0
TRHDE	29953	broad.mit.edu	37	12	72680679	72680679	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr12:72680679C>G	ENST00000261180.4	+	2	1094	c.998C>G	c.(997-999)gCc>gGc	p.A333G		NM_013381.2	NP_037513.1	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	333					cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(38)|ovary(2)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	79						TATTATTTAGCCTGGGCAATT	0.398000													20	56					0	0	1	0	0
CPSF2	53981	broad.mit.edu	37	14	92609452	92609452	+	Silent	SNP	C	C	G			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr14:92609452C>G	ENST00000298875.4	+	9	1239	c.954C>G	c.(952-954)gcC>gcG	p.A318A		NM_017437.2	NP_059133.1	Q9P2I0	CPSF2_HUMAN	cleavage and polyadenylation specific factor 2, 100kDa	318					histone mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	hydrolase activity|protein binding|RNA binding			breast(2)|cervix(1)|endometrium(3)|large_intestine(2)|lung(7)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	24		all_cancers(154;0.0766)		COAD - Colon adenocarcinoma(157;0.222)		CTGACTTGGCCCGTGTACCTA	0.418000													40	30					0	0	1	0	0
SRCAP	10847	broad.mit.edu	37	16	30745264	30745264	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr16:30745264C>G	ENST00000262518.4	+	30	6929	c.6544C>G	c.(6544-6546)Cag>Gag	p.Q2182E	SRCAP_ENST00000395059.2_Missense_Mutation_p.Q2120E|SRCAP_ENST00000344771.4_Missense_Mutation_p.Q2024E	NM_006662.2	NP_006653.2	Q6ZRS2	SRCAP_HUMAN	Snf2-related CREBBP activator protein	2182	Helicase C-terminal.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			AAAGGCAAATCAGAAGAGAAT	0.463000													13	19					0	0	1	0	0
BAG4	9530	broad.mit.edu	37	8	38050240	38050240	+	Missense_Mutation	SNP	A	A	G			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr8:38050240A>G	ENST00000287322.4	+	2	576	c.305A>G	c.(304-306)tAt>tGt	p.Y102C	BAG4_ENST00000521282.1_3'UTR|BAG4_ENST00000432471.2_Intron	NM_004874.3	NP_004865.1	O95429	BAG4_HUMAN	BCL2-associated athanogene 4	102					anti-apoptosis|apoptosis|protein folding	cytoplasm|nucleus	receptor signaling protein activity			breast(1)|kidney(2)|large_intestine(2)|liver(2)|lung(2)|ovary(1)|urinary_tract(1)	11	Colorectal(12;0.000442)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.121)				AATTCTAACTATTGGAATTCT	0.353000													14	49					0	0	1	0	0
CKS1B	1163	broad.mit.edu	37	1	154951209	154951210	+	Frame_Shift_Ins	INS	-	-	T			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr1:154951209_154951210insT	ENST00000368439.1	+	3	397_398	c.148_149insT	c.(148-150)cttfs	p.L50fs	CKS1B_ENST00000308987.5_Frame_Shift_Ins_p.L66fs|CKS1B_ENST00000471245.1_3'UTR			P61024	CKS1_HUMAN	CDC28 protein kinase regulatory subunit 1B	66					cell division|cell proliferation|G1/S transition of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|S phase of mitotic cell cycle	nucleoplasm	cyclin-dependent protein kinase regulator activity|protein binding			breast(1)|large_intestine(1)|lung(1)	3	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			AGAACCTCACATCTTGCTGTTC	0.465													8	21	---	---	---	---					
GON4L	54856	broad.mit.edu	37	1	155735634	155735637	+	Frame_Shift_Del	DEL	GCCA	GCCA	-			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr1:155735634_155735637delGCCA	ENST00000437809.1	-	21	3749_3752	c.3627_3630delTGGC	c.(3625-3630)tcfs	p.SG1209fs	GON4L_ENST00000361040.5_Frame_Shift_Del_p.SG1209fs|GON4L_ENST00000368331.1_Frame_Shift_Del_p.SG1209fs|GON4L_ENST00000271883.5_Frame_Shift_Del_p.SG1209fs|GON4L_ENST00000471341.1_5'UTR			Q3T8J9	GON4L_HUMAN	gon-4-like (C. elegans)	1209					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(4)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	45	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					TCACAGAATTGCCAGAAACAATTA	0.490													9	60	---	---	---	---					
H3F3AP4	440926	broad.mit.edu	37	2	175585079	175585079	+	RNA	DEL	A	A	-			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr2:175585079delA	ENST00000442996.1	+	0	217																											TTTCATTCTCAAAAAAAAAAA	0.368											OREG0015078	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	5	---	---	---	---					
DOCK5	80005	broad.mit.edu	37	8	25222144	25222144	+	Frame_Shift_Del	DEL	T	T	-			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr8:25222144delT	ENST00000276440.7	+	30	3091	c.3047delT	c.(3046-3048)gtfs	p.V1016fs		NM_024940.6	NP_079216.4	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	1016						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(9)|large_intestine(13)|lung(20)|ovary(3)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	72		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		TTCCGCAGGGTTTTTCTCCGT	0.418													2	4	---	---	---	---					
RP11-377D9.3	0	broad.mit.edu	37	12	13174142	13174147	+	RNA	DEL	AACAAC	AACAAC	-	rs113537246		TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr12:13174142_13174147delAACAAC	ENST00000543321.1	+	0	1025																											ctgtctcaaaaacaacaacaacaaca	0.553													3	4	---	---	---	---					
JPH3	57338	broad.mit.edu	37	16	87723649	87723649	+	Frame_Shift_Del	DEL	G	G	-			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr16:87723649delG	ENST00000284262.2	+	4	1925	c.1683delG	c.(1681-1683)tcfs	p.S561fs	JPH3_ENST00000563609.1_3'UTR	NM_020655.2	NP_065706.2	Q8WXH2	JPH3_HUMAN	junctophilin 3	561					calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	30				BRCA - Breast invasive adenocarcinoma(80;0.0287)		CCCGAGGTTCGGGCCGCAAGC	0.741													2	4	---	---	---	---					
ZNF528-AS1	102724105	broad.mit.edu	37	19	52896073	52896074	+	RNA	DEL	TA	TA	-			TCGA-D6-A4Z9-01A-11D-A25D-08	TCGA-D6-A4Z9-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3279137c-938d-4043-8aa7-f92d3acac353	f96baddb-030d-4c48-a806-399713ca18ac	g.chr19:52896073_52896074delTA	ENST00000601562.1	-	0	784																											GTGGAAGCTGTATATATATATA	0.460													2	4	---	---	---	---