Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TACC2	10579	broad.mit.edu	37	10	123989891	123989891	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr10:123989891G>A	ENST00000369005.1	+	16	8403	c.8063G>A	c.(8062-8064)cGg>cAg	p.R2688Q	TACC2_ENST00000369004.3_Intron|TACC2_ENST00000513429.1_Missense_Mutation_p.R834Q|TACC2_ENST00000358010.1_Missense_Mutation_p.R834Q|TACC2_ENST00000515603.1_Intron|TACC2_ENST00000453444.2_Intron|TACC2_ENST00000369000.1_Intron|TACC2_ENST00000369001.1_Intron|TACC2_ENST00000334433.3_Missense_Mutation_p.R2688Q|TACC2_ENST00000368999.1_Missense_Mutation_p.R778Q|TACC2_ENST00000360561.3_Intron|TACC2_ENST00000260733.3_Missense_Mutation_p.R766Q|TACC2_ENST00000515273.1_Intron	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	2688						microtubule organizing center|nucleus	nuclear hormone receptor binding	p.R2688Q(1)		NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				GCCATCATGCGGATAGAAGCC	0.567000													35	93					0	0	0.788014	0	0
IGHV1-46	28465	broad.mit.edu	37	14	106967517	106967517	+	RNA	SNP	G	G	C			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr14:106967517G>C	ENST00000390622.2	-	0	271																											GGCTTCTGTAGAGAAGGGATG	0.468000													19	31					0	0	0.539581	0	0
SLC4A7	9497	broad.mit.edu	37	3	27431585	27431585	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr3:27431585C>T	ENST00000295736.5	-	22	3240	c.3170G>A	c.(3169-3171)cGt>cAt	p.R1057H	SLC4A7_ENST00000425128.2_3'UTR|SLC4A7_ENST00000445684.1_Missense_Mutation_p.R1053H|SLC4A7_ENST00000455077.1_Missense_Mutation_p.R938H|SLC4A7_ENST00000435667.2_Missense_Mutation_p.R942H|SLC4A7_ENST00000440156.1_Missense_Mutation_p.R1053H|SLC4A7_ENST00000388777.4_Missense_Mutation_p.R607H|SLC4A7_ENST00000428386.1_Missense_Mutation_p.R933H|SLC4A7_ENST00000446700.1_Missense_Mutation_p.R1049H|SLC4A7_ENST00000454389.1_Missense_Mutation_p.R1066H|SLC4A7_ENST00000437179.1_Missense_Mutation_p.R938H	NM_003615.4	NP_003606.3	Q9Y6M7	S4A7_HUMAN	solute carrier family 4, sodium bicarbonate cotransporter, member 7	1057						apical plasma membrane|basolateral plasma membrane|integral to membrane|stereocilium	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			NS(2)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(12)|lung(9)|ovary(4)|skin(1)	38						TAATTTTATACGGTCAAATAA	0.328000													4	163					0	0	0.217242	0	0
WASH3P	374666	broad.mit.edu	37	15	102515299	102515299	+	RNA	SNP	G	G	A			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr15:102515299G>A	ENST00000557932.1	+	0	1145																		p.G374S(10)		central_nervous_system(1)|endometrium(6)|kidney(11)|prostate(5)|stomach(1)|urinary_tract(1)	25						TGGGGGCATCGGCAAGGCCAA	0.652000													3	31					0	0	0.150653	0	0
DNAH2	146754	broad.mit.edu	37	17	7668743	7668743	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr17:7668743G>A	ENST00000572933.1	+	21	4831	c.3371G>A	c.(3370-3372)tGg>tAg	p.W1124*	DNAH2_ENST00000389173.2_Nonsense_Mutation_p.W1124*			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	1124	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				AACGGGGAGTGGGTTGTCTTC	0.537000													28	74					0	0	0.693898	0	0
RPP25L	138716	broad.mit.edu	37	9	34610878	34610878	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr9:34610878G>C	ENST00000297613.4	-	2	696	c.416C>G	c.(415-417)cCc>cGc	p.P139R	RPP25L_ENST00000378959.4_Missense_Mutation_p.P139R	NM_148179.2	NP_680545.1	Q8N5L8	CI023_HUMAN	ribonuclease P/MRP 25kDa subunit-like	139							nucleic acid binding										CAGGCCAGGGGGTGCTCCTGG	0.657000													26	65					0	0	0.729181	0	0
ASH2L	9070	broad.mit.edu	37	8	37986388	37986388	+	Silent	SNP	G	G	A			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr8:37986388G>A	ENST00000343823.6	+	12	1755	c.1446G>A	c.(1444-1446)caG>caA	p.Q482Q	ASH2L_ENST00000545394.1_Silent_p.Q343Q|ASH2L_ENST00000521652.1_Silent_p.Q388Q|ASH2L_ENST00000428278.2_Silent_p.Q388Q|ASH2L_ENST00000250635.7_Silent_p.Q388Q	NM_004674.4	NP_004665.2	Q9UBL3	ASH2L_HUMAN	ash2 (absent, small, or homeotic)-like (Drosophila)	482	B30.2/SPRY.				hemopoiesis|histone H3-K4 methylation|positive regulation of cell proliferation|regulation of transcription, DNA-dependent|response to estrogen stimulus|transcription from RNA polymerase II promoter	Set1C/COMPASS complex	metal ion binding|protein binding|transcription regulatory region DNA binding			NS(1)|endometrium(5)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)|stomach(1)	19	Colorectal(12;0.000501)	Lung NSC(58;0.0295)|all_lung(54;0.0413)				GCTATGGACAGGGAGACGTCC	0.443000													108	487					0	0	0.870114	0	0
SLC24A2	25769	broad.mit.edu	37	9	19619581	19619581	+	Splice_Site	SNP	C	C	T			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr9:19619581C>T	ENST00000341998.2	-	3	1140		c.e3+1		SLC24A2_ENST00000286344.3_Splice_Site	NM_001193288.2|NM_020344.3	NP_001180217.1|NP_065077.1	Q9UI40	NCKX2_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 2						visual perception	integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			endometrium(3)|kidney(1)|large_intestine(9)|lung(13)|ovary(3)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	33				GBM - Glioblastoma multiforme(1;1.67e-55)|Lung(42;0.0443)		TTGATGTTTACCTTCGGCGAG	0.512000													46	155					0	0	0.870114	0	0
TBC1D9	23158	broad.mit.edu	37	4	141583131	141583131	+	Silent	SNP	A	A	T			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr4:141583131A>T	ENST00000442267.2	-	10	1793	c.1719T>A	c.(1717-1719)gcT>gcA	p.A573A		NM_015130.2	NP_055945.2	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	573	Rab-GAP TBC.					intracellular	calcium ion binding|Rab GTPase activator activity			endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	31	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				CATTCTGAAAAGCTGGGTGTT	0.468000													24	58					0	0	0.693898	0	0
OTOGL	283310	broad.mit.edu	37	12	80726828	80726828	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr12:80726828G>A	ENST00000458043.2	+	37	4371	c.4365G>A	c.(4363-4365)atG>atA	p.M1455I	OTOGL_ENST00000547103.1_Missense_Mutation_p.M1443I	NM_173591.3	NP_775862.3			otogelin-like											breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						TGTTTGATATGCTAACACCAA	0.363000													8	21					0	0	0.278610	0	0
KPRP	448834	broad.mit.edu	37	1	152732235	152732235	+	Silent	SNP	C	C	T			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr1:152732235C>T	ENST00000368773.1	+	2	229	c.171C>T	c.(169-171)tgC>tgT	p.C57C	KPRP_ENST00000606109.1_Silent_p.C57C	NM_001025231.1	NP_001020402.1	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	57	Gln-rich.					cytoplasm				NS(1)|breast(1)|endometrium(9)|kidney(1)|large_intestine(10)|lung(21)|ovary(6)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTCAAGTTTGCCAGGTGTCAG	0.547000													30	79					0	0	0.717897	0	0
SP140L	93349	broad.mit.edu	37	2	231223763	231223763	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr2:231223763C>A	ENST00000243810.6	+	4	355	c.355C>A	c.(355-357)Ctg>Atg	p.L119M	SP140L_ENST00000444636.1_Missense_Mutation_p.L119M|SP140L_ENST00000396563.4_Missense_Mutation_p.L119M|SP140L_ENST00000458341.1_Missense_Mutation_p.L32M|SP140L_ENST00000415673.2_Missense_Mutation_p.L119M			Q9H930	LY10L_HUMAN	SP140 nuclear body protein-like	119	HSR.					nucleus	DNA binding|metal ion binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(7)|prostate(1)|skin(1)	20						GACATTTAACCTGTCAGTTTT	0.358000													4	161					0.014758	0.0153405	0.184627	1	0
GPR98	84059	broad.mit.edu	37	5	89943471	89943471	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr5:89943471C>T	ENST00000405460.2	+	17	3275	c.3179C>T	c.(3178-3180)aCg>aTg	p.T1060M		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	1060	Calx-beta 8.				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		AAAGGAGAAACGCTCATTTTT	0.413000													33	139					0	0	0.779181	0	0
CCM2L	140706	broad.mit.edu	37	20	30617557	30617557	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr20:30617557G>A	ENST00000300415.8	+	9	1331	c.1318G>A	c.(1318-1320)Gag>Aag	p.E440K	CCM2L_ENST00000262659.8_Silent_p.G418G|RP1-310O13.7_ENST00000449519.1_RNA					cerebral cavernous malformation 2-like																		GCTGCTGCGGGAGTACCGGCT	0.617000													11	54					0	0	0.479597	0	0
PCDH8	5100	broad.mit.edu	37	13	53420242	53420242	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr13:53420242C>T	ENST00000377942.3	-	1	2533	c.2330G>A	c.(2329-2331)cGc>cAc	p.R777H	PCDH8_ENST00000338862.4_Missense_Mutation_p.R777H	NM_002590.3	NP_002581.2	O95206	PCDH8_HUMAN	protocadherin 8	777					cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(23)|ovary(1)|skin(1)|urinary_tract(1)	36		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		CTCCTTCTTGCGGCGGTTGCA	0.741000													15	17					0	0	0.608945	0	0
RRN3P2	653390	broad.mit.edu	37	16	29110458	29110458	+	RNA	SNP	T	T	C	rs151074589	by1000genomes	TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr16:29110458T>C	ENST00000564580.1	+	0	1131																		p.W375R(25)									GAATTTTGAGTGGATAGTGAT	0.328000													4	48					0	0	0.217242	0	0
KIF1A	547	broad.mit.edu	37	2	241722504	241722504	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr2:241722504G>A	ENST00000498729.2	-	9	1067	c.821C>T	c.(820-822)tCg>tTg	p.S274L	KIF1A_ENST00000320389.7_Missense_Mutation_p.S274L	NM_001244008.1	NP_001230937.1	Q12756	KIF1A_HUMAN	kinesin family member 1A	274	Kinesin-motor.				anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			NS(1)|central_nervous_system(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(25)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	66		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		GGTGGTCAGCGACTTGTTGAT	0.657000													24	40					0	0	0.667858	0	0
XYLT1	64131	broad.mit.edu	37	16	17202658	17202658	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr16:17202658G>C	ENST00000261381.6	-	12	2858	c.2774C>G	c.(2773-2775)aCa>aGa	p.T925R		NM_022166.3	NP_071449.1	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	925					glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						CGGGCAGGCTGTGGGGCCCGT	0.677000													9	19					0	0	0.307466	0	0
ATP5A1	498	broad.mit.edu	37	18	43666161	43666161	+	Silent	SNP	G	G	A	rs141613719		TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr18:43666161G>A	ENST00000593152.2	-	10	1736	c.1197C>T	c.(1195-1197)ttC>ttT	p.F399F	ATP5A1_ENST00000398752.6_Silent_p.F449F|ATP5A1_ENST00000590665.1_Silent_p.F427F|ATP5A1_ENST00000282050.2_Silent_p.F449F	NM_001257335.1	NP_001244264.1	P25705	ATPA_HUMAN	ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle	449					ATP hydrolysis coupled proton transport|embryo development|lipid metabolic process|negative regulation of endothelial cell proliferation|respiratory electron transport chain	mitochondrial matrix|plasma membrane	ATP binding|eukaryotic cell surface binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|MHC class I protein binding|proton-transporting ATPase activity, rotational mechanism			breast(2)|endometrium(1)|kidney(2)|large_intestine(7)|lung(8)|skin(1)|urinary_tract(1)	22						GGTCAGAACCGAACTGGGCAA	0.458000													52	44					0	0	0.870114	0	0
LRP1B	53353	broad.mit.edu	37	2	141267498	141267498	+	Splice_Site	SNP	G	G	A			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr2:141267498G>A	ENST00000389484.3	-	52	9368	c.8398_splice	c.e52+1	p.C2799_splice		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	2799	LDL-receptor class A 17.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding	p.C2799C(2)		NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TGTTCATACCGCAGCCTGCTG	0.507000										TSP Lung(27;0.18)			4	110					0	0	0.150653	0	0
MC3R	4159	broad.mit.edu	37	20	54823948	54823948	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr20:54823948G>A	ENST00000243911.2	+	1	161	c.49G>A	c.(49-51)Ggc>Agc	p.G17S		NM_019888.3	NP_063941.3	P41968	MC3R_HUMAN	melanocortin 3 receptor	54					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|protein binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(3)|lung(13)|ovary(3)|skin(1)	26			Colorectal(105;0.202)			ACTGCCTAATGGCTCGGAGCA	0.582000													56	153					0	0	0.870114	0	0
MAPKAP1	79109	broad.mit.edu	37	9	128347842	128347842	+	Silent	SNP	C	C	T			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr9:128347842C>T	ENST00000265960.3	-	5	995	c.663G>A	c.(661-663)ccG>ccA	p.P221P	MAPKAP1_ENST00000373503.3_Silent_p.P29P|MAPKAP1_ENST00000350766.3_Silent_p.P221P|MAPKAP1_ENST00000373497.5_Silent_p.P29P|MAPKAP1_ENST00000394060.3_Silent_p.P221P|MAPKAP1_ENST00000394063.1_Silent_p.P29P|MAPKAP1_ENST00000373511.2_Silent_p.P221P|MAPKAP1_ENST00000373498.1_Silent_p.P221P	NM_001006617.1	NP_001006618.1	Q9BPZ7	SIN1_HUMAN	mitogen-activated protein kinase associated protein 1	221					nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|response to stress|T cell costimulation	cytoplasmic membrane-bounded vesicle|cytosol|nucleus|plasma membrane	Ras GTPase binding	p.P221P(1)		endometrium(2)|kidney(1)|large_intestine(2)|lung(15)|ovary(3)	23						ACTTGAGCTTCGGCTCCCGTC	0.532000													26	111					0	0	0.706142	0	0
EIF2AK1	27102	broad.mit.edu	37	7	6077066	6077066	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr7:6077066G>A	ENST00000199389.6	-	11	1467	c.1321C>T	c.(1321-1323)Cga>Tga	p.R441*	EIF2AK1_ENST00000536084.1_Nonsense_Mutation_p.R317*	NM_001134335.1|NM_014413.3	NP_001127807.1|NP_055228.2	Q9BQI3	E2AK1_HUMAN	eukaryotic translation initiation factor 2-alpha kinase 1	441	Protein kinase.				negative regulation of hemoglobin biosynthetic process|negative regulation of translational initiation by iron|protein autophosphorylation|response to external stimulus|response to stress	cytoplasm	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|heme binding|protein homodimerization activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)	27		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.106)|OV - Ovarian serous cystadenocarcinoma(56;5.22e-14)		TTCAGATCTCGGTGCACAATT	0.378000													32	45					0	0	0.804634	0	0
KLHL17	339451	broad.mit.edu	37	1	898584	898584	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr1:898584G>T	ENST00000338591.3	+	7	1245	c.1138G>T	c.(1138-1140)Gcc>Tcc	p.A380S		NM_198317.2	NP_938073.1	Q6TDP4	KLH17_HUMAN	kelch-like family member 17	380	Interaction with F-actin (By similarity).				actin cytoskeleton organization	actin cytoskeleton|cell junction|postsynaptic density|postsynaptic membrane	protein complex scaffold			central_nervous_system(1)|kidney(2)|lung(3)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	10	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;1.52e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.59e-23)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|BRCA - Breast invasive adenocarcinoma(365;0.000469)|Kidney(185;0.00227)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		CACGCGCCGGGCCCGGGTGGG	0.716000													4	13					0.00024832	0.000261564	0.150653	1	0
PIK3C2G	5288	broad.mit.edu	37	12	18435208	18435208	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr12:18435208G>T	ENST00000433979.1	+	2	309	c.193G>T	c.(193-195)Gtg>Ttg	p.V65L	PIK3C2G_ENST00000535651.1_Missense_Mutation_p.V65L|RERGL_ENST00000541632.1_Intron|PIK3C2G_ENST00000266497.5_Missense_Mutation_p.V65L|PIK3C2G_ENST00000538779.1_Missense_Mutation_p.V65L	NM_004570.4	NP_004561.3	O75747	P3C2G_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma	65					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			breast(5)|central_nervous_system(6)|endometrium(2)|kidney(4)|large_intestine(8)|lung(31)|ovary(2)|prostate(1)|skin(2)|stomach(4)|upper_aerodigestive_tract(1)	66		Hepatocellular(102;0.194)				CACCTTTTTTGTGCCCACTGC	0.408000													4	86					0.150653	0.154567	0.150653	1	0
PRRC2B	84726	broad.mit.edu	37	9	134367624	134367624	+	Silent	SNP	C	C	T			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr9:134367624C>T	ENST00000357304.4	+	29	6505	c.6450C>T	c.(6448-6450)ccC>ccT	p.P2150P	PRRC2B_ENST00000405995.1_Silent_p.P1456P|PRRC2B_ENST00000372249.1_Silent_p.P247P|PRRC2B_ENST00000465931.1_3'UTR|PRRC2B_ENST00000458550.1_Silent_p.P1456P	NM_013318.3	NP_037450.2	Q5JSZ5	PRC2B_HUMAN	proline-rich coiled-coil 2B	2150							protein binding			cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(20)|ovary(2)	44						CAGGAGGCCCCGTGCCATCGC	0.552000													15	88					0	0	0.500413	0	0
ZHX2	22882	broad.mit.edu	37	8	123966105	123966105	+	Silent	SNP	C	C	T			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr8:123966105C>T	ENST00000314393.4	+	3	3190	c.2355C>T	c.(2353-2355)aaC>aaT	p.N785N		NM_014943.3	NP_055758.1	Q9Y6X8	ZHX2_HUMAN	zinc fingers and homeoboxes 2	785						cytoplasm|nucleus|plasma membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(15)|ovary(1)|prostate(1)|skin(4)|stomach(3)|urinary_tract(1)	45	Lung NSC(37;2e-09)|Ovarian(258;0.0205)|Hepatocellular(40;0.105)		STAD - Stomach adenocarcinoma(47;0.00527)			GCGACGAGAACGAGGAGTCGA	0.612000													9	31					0	0	0.335167	0	0
ZCCHC4	29063	broad.mit.edu	37	4	25314436	25314436	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr4:25314436C>T	ENST00000302874.4	+	1	29	c.5C>T	c.(4-6)gCg>gTg	p.A2V	ZCCHC4_ENST00000505451.1_3'UTR	NM_024936.2	NP_079212.2	Q9H5U6	ZCHC4_HUMAN	zinc finger, CCHC domain containing 4	2							methyltransferase activity|nucleic acid binding|zinc ion binding			endometrium(1)|large_intestine(3)|lung(2)|ovary(2)|pancreas(1)	9		Breast(46;0.0503)				GGGAAGATGGCGGCCTCCAGG	0.652000											OREG0016141	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	174					0	0	0.184627	0	0
NAB2	4665	broad.mit.edu	37	12	57485446	57485446	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr12:57485446T>C	ENST00000300131.3	+	2	1000	c.622T>C	c.(622-624)Ttc>Ctc	p.F208L	NAB2_ENST00000342556.6_Missense_Mutation_p.F208L|NAB2_ENST00000554718.1_3'UTR|NAB2_ENST00000357680.4_Missense_Mutation_p.F208L	NM_005967.3	NP_005958.1	Q15742	NAB2_HUMAN	NGFI-A binding protein 2 (EGR1 binding protein 2)	208					cell proliferation|negative regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	nucleus	transcription corepressor activity	p.F208L(1)		breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|ovary(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	20						CTCGCCCCCCTTCTCCCCCCC	0.716000													6	37					0	0	0.307466	0	0
DPP9	91039	broad.mit.edu	37	19	4684712	4684712	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr19:4684712C>A	ENST00000262960.9	-	18	2418	c.2141G>T	c.(2140-2142)cGa>cTa	p.R714L	DPP9_ENST00000601173.1_5'UTR|AC005594.3_ENST00000381796.1_RNA|DPP9_ENST00000594671.1_Missense_Mutation_p.R685L|DPP9_ENST00000598800.1_Missense_Mutation_p.R685L	NM_139159.4	NP_631898.3	Q86TI2	DPP9_HUMAN	dipeptidyl-peptidase 9	685					proteolysis	cytosol|membrane	aminopeptidase activity|serine-type peptidase activity			cervix(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00884)		CCGAAGCCCTCGCTGACAGGA	0.582000													7	15					1.26484e-09	1.3688e-09	0.278610	1	0
GLOD4	51031	broad.mit.edu	37	17	685428	685428	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr17:685428T>C	ENST00000301329.6	-	1	153	c.68A>G	c.(67-69)tAt>tGt	p.Y23C	GLOD4_ENST00000536578.1_5'UTR|GLOD4_ENST00000301328.5_Missense_Mutation_p.Y23C	NM_016080.3	NP_057164.3	Q9HC38	GLOD4_HUMAN	glyoxalase domain containing 4	23						mitochondrion				endometrium(1)|large_intestine(1)|prostate(1)	3				UCEC - Uterine corpus endometrioid carcinoma (25;0.022)		GACGTCCCGATAGAAACGCGC	0.692000													13	32					0	0	0.435327	0	0
PPP1R10	5514	broad.mit.edu	37	6	30571952	30571952	+	Silent	SNP	C	C	T			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr6:30571952C>T	ENST00000376511.2	-	14	1893	c.1341G>A	c.(1339-1341)gcG>gcA	p.A447A		NM_002714.3	NP_002705.2	Q96QC0	PP1RA_HUMAN	protein phosphatase 1, regulatory subunit 10	447	Essential for PPP1CA inhibition (By similarity).|Interaction with WDR82 (By similarity).				protein import into nucleus|transcription, DNA-dependent	PTW/PP1 phosphatase complex	DNA binding|protein phosphatase inhibitor activity|RNA binding|zinc ion binding			cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(9)|ovary(2)|prostate(3)|skin(1)	25						TCAGACGCCGCGCTGTCTCAA	0.552000													109	45					0	0	0.870114	0	0
DHX58	79132	broad.mit.edu	37	17	40253880	40253880	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr17:40253880G>A	ENST00000251642.3	-	14	2158	c.1936C>T	c.(1936-1938)Cgg>Tgg	p.R646W		NM_024119.2	NP_077024.2	Q96C10	DHX58_HUMAN	DEXH (Asp-Glu-X-His) box polypeptide 58	646	RNA-binding.				innate immune response	cytoplasm	ATP binding|DNA binding|helicase activity|protein binding|RNA binding|zinc ion binding			breast(2)|endometrium(3)|large_intestine(3)|lung(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		all_cancers(22;9.73e-07)|all_epithelial(22;3.58e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		GCCTGGATCCGCCCCTGAGGG	0.587000											OREG0024418	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	68					0	0	0.479597	0	0
RIMBP3	85376	broad.mit.edu	37	22	20458538	20458538	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr22:20458538G>A	ENST00000426804.1	-	1	3248	c.2764C>T	c.(2764-2766)Cag>Tag	p.Q922*		NM_015672.1	NP_056487.1			RIMS binding protein 3											breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(1)|prostate(1)|skin(1)|urinary_tract(1)	13	Colorectal(54;0.0993)|Melanoma(16;0.165)		LUSC - Lung squamous cell carcinoma(15;0.0405)|Lung(15;0.224)			GCTTCATCCTGCCCCGCTGGG	0.597000													10	34					0	0	0.387290	0	0
POM121L12	285877	broad.mit.edu	37	7	53103445	53103445	+	Silent	SNP	C	C	T			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr7:53103445C>T	ENST00000408890.4	+	1	97	c.81C>T	c.(79-81)gaC>gaT	p.D27D		NM_182595.3	NP_872401.3	Q8N7R1	P1L12_HUMAN	POM121 transmembrane nucleoporin-like 12	27										endometrium(5)|kidney(1)|large_intestine(5)|lung(44)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	61						AAGGCCCCGACGCCCTGGCGG	0.701000													7	13					0	0	0.248553	0	0
NAA11	84779	broad.mit.edu	37	4	80247011	80247011	+	Silent	SNP	C	C	T			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr4:80247011C>T	ENST00000286794.4	-	1	193	c.21G>A	c.(19-21)caG>caA	p.Q7Q		NM_032693.2	NP_116082.1	Q9BSU3	NAA11_HUMAN	N(alpha)-acetyltransferase 11, NatA catalytic subunit	7	Interaction with NAA15 (By similarity).|N-acetyltransferase.					cytoplasm|nucleus	peptide alpha-N-acetyltransferase activity|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(9)|ovary(1)|pancreas(1)|skin(2)	23						GGTCGTCTGGCTGAGCGTTGC	0.522000													15	25					0	0	0.500413	0	0
RPL4	6124	broad.mit.edu	37	15	66795855	66795855	+	Missense_Mutation	SNP	G	G	A	rs142487012		TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr15:66795855G>A	ENST00000307961.6	-	2	108	c.16C>T	c.(16-18)Cca>Tca	p.P6S	RPL4_ENST00000568588.1_5'UTR	NM_000968.3	NP_000959.2	P36578	RL4_HUMAN	ribosomal protein L4	6					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	protein binding|RNA binding|structural constituent of ribosome			endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|skin(1)|stomach(1)|urinary_tract(1)	17						GATATCAGTGGGCGAGCACAC	0.403000													26	11					0	0	0.693898	0	0
TUBB8P7	197331	broad.mit.edu	37	16	90161902	90161902	+	RNA	SNP	A	A	G	rs6500471	by1000genomes	TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr16:90161902A>G	ENST00000564451.1	+	0	1255				TUBB8P7_ENST00000567960.1_RNA														p.K213R(8)									ATATGTTCCAAGACCCTAAAA	0.537000													5	5					0	0	0.217242	0	0
EGF	1950	broad.mit.edu	37	4	110915936	110915936	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr4:110915936G>A	ENST00000265171.5	+	20	3350	c.2905G>A	c.(2905-2907)Gta>Ata	p.V969I	EGF_ENST00000503392.1_Missense_Mutation_p.V928I|EGF_ENST00000509793.1_Missense_Mutation_p.V927I	NM_001178130.1|NM_001963.4	NP_001171601.1|NP_001954.2	P01133	EGF_HUMAN	epidermal growth factor	969					angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			breast(1)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	CCACTATTCCGTAAGAAATAG	0.443000													27	47					0	0	0.717897	0	0
LSS	4047	broad.mit.edu	37	21	47626627	47626627	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr21:47626627C>T	ENST00000397728.3	-	16	1601	c.1523G>A	c.(1522-1524)gGg>gAg	p.G508E	LSS_ENST00000356396.4_Missense_Mutation_p.G508E|LSS_ENST00000457828.2_Missense_Mutation_p.G428E|LSS_ENST00000522411.1_Missense_Mutation_p.G497E	NM_001145436.1|NM_002340.5	NP_001138908.1|NP_002331.3	P48449	ERG7_HUMAN	lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)	508					cholesterol biosynthetic process	endoplasmic reticulum membrane	lanosterol synthase activity			cervix(1)|endometrium(6)|kidney(1)|large_intestine(3)|liver(1)|lung(7)|skin(1)|urinary_tract(1)	21	Breast(49;0.214)					CAAGTGCCCCCCACGCTTGGT	0.602000													20	56					0	0	0.624587	0	0
DSN1	79980	broad.mit.edu	37	20	35399490	35399490	+	Silent	SNP	G	G	A	rs139234953		TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr20:35399490G>A	ENST00000426836.1	-	3	513	c.141C>T	c.(139-141)ggC>ggT	p.G47G	DSN1_ENST00000473615.1_Intron|DSN1_ENST00000373734.4_Intron|DSN1_ENST00000448110.1_Silent_p.G31G|DSN1_ENST00000373740.3_Intron|DSN1_ENST00000373745.3_Silent_p.G47G|DSN1_ENST00000373750.4_Silent_p.G47G	NM_001145316.1	NP_001138788.1	Q9H410	DSN1_HUMAN	DSN1, MIS12 kinetochore complex component	47					cell division|chromosome segregation|mitotic prometaphase	cytosol|MIS12/MIND type complex|nucleus	protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	16		Myeloproliferative disorder(115;0.00874)				CCTCTGAAACGCCTTGATTCA	0.448000													53	205					0	0	0.870114	0	0
CROCCP2	84809	broad.mit.edu	37	1	16956460	16956460	+	RNA	SNP	A	A	C			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr1:16956460A>C	ENST00000412962.1	-	0	294																											tgcctgggcaattttttaaat	0.572000													2	5					0	0	0.115264	0	0
MTF1	4520	broad.mit.edu	37	1	38323083	38323083	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr1:38323083A>G	ENST00000373036.4	-	2	388	c.248T>C	c.(247-249)cTg>cCg	p.L83P	MTF1_ENST00000468190.1_5'UTR	NM_005955.2	NP_005946.2	Q14872	MTF1_HUMAN	metal-regulatory transcription factor 1	83						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|zinc ion binding			endometrium(3)|kidney(5)|large_intestine(6)|liver(1)|lung(12)|ovary(2)|pancreas(1)|prostate(1)	31	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				ATGATCTATCAGGTGAAAGCC	0.483000													3	80					0	0	0.115264	0	0
FAM149A	25854	broad.mit.edu	37	4	187074901	187074901	+	Silent	SNP	C	C	T			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr4:187074901C>T	ENST00000356371.5	+	5	1062	c.1062C>T	c.(1060-1062)tgC>tgT	p.C354C	FAM149A_ENST00000502970.1_Silent_p.C63C|FAM149A_ENST00000389354.5_Silent_p.C63C|FAM149A_ENST00000227065.4_Silent_p.C63C|FAM149A_ENST00000514829.1_3'UTR|FAM149A_ENST00000503432.1_Silent_p.C63C|FAM149A_ENST00000514153.1_Silent_p.C63C			A5PLN7	F149A_HUMAN	family with sequence similarity 149, member A	354										breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(8)|lung(8)|pancreas(1)|prostate(1)|skin(2)	25		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.19e-10)|BRCA - Breast invasive adenocarcinoma(30;1.22e-05)|GBM - Glioblastoma multiforme(59;0.000122)|STAD - Stomach adenocarcinoma(60;0.000288)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.166)		TCAGTGCCTGCGGACACAGCA	0.468000													4	174					0	0	0.150653	0	0
GPC5	2262	broad.mit.edu	37	13	92345950	92345950	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr13:92345950C>T	ENST00000377067.3	+	3	1207	c.835C>T	c.(835-837)Cga>Tga	p.R279*		NM_004466.4	NP_004457.1	P78333	GPC5_HUMAN	glypican 5	279						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			NS(1)|breast(4)|endometrium(6)|kidney(4)|large_intestine(7)|lung(34)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				CAATGTCATGCGAGGCTGCCT	0.542000													22	27					0	0	0.608945	0	0
ILK	3611	broad.mit.edu	37	11	6630568	6630568	+	Silent	SNP	G	G	A			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr11:6630568G>A	ENST00000396751.2	+	7	1113	c.657G>A	c.(655-657)gtG>gtA	p.V219V	ILK_ENST00000299421.4_Silent_p.V219V|ILK_ENST00000526711.1_3'UTR|ILK_ENST00000420936.2_Silent_p.V219V|ILK_ENST00000537806.1_Silent_p.V85V|ILK_ENST00000528995.1_Silent_p.V158V|RP11-732A19.2_ENST00000527398.1_RNA	NM_001014795.1	NP_001014795.1	Q13418	ILK_HUMAN	integrin-linked kinase	219	Protein kinase.				cell junction assembly|cell proliferation|cell-matrix adhesion|integrin-mediated signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of phosphorylation|positive regulation of transcription, DNA-dependent	cytosol|focal adhesion	ATP binding|protein serine/threonine kinase activity			central_nervous_system(1)	1		Breast(177;7.61e-05)|Medulloblastoma(188;0.00263)|all_neural(188;0.026)|all_lung(207;0.152)		Epithelial(150;5.49e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00012)|Lung(200;0.00942)|LUSC - Lung squamous cell carcinoma(625;0.0163)		ACATTGTCGTGAAGGTGCTGA	0.547000													24	57					0	0	0.717897	0	0
TCERG1	10915	broad.mit.edu	37	5	145851099	145851099	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr5:145851099G>A	ENST00000296702.5	+	9	1599	c.1561G>A	c.(1561-1563)Gca>Aca	p.A521T	TCERG1_ENST00000394421.2_Missense_Mutation_p.A500T	NM_006706.3	NP_006697.2	O14776	TCRG1_HUMAN	transcription elongation regulator 1	521					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity			breast(1)|central_nervous_system(3)|endometrium(5)|kidney(4)|large_intestine(18)|lung(9)|ovary(2)|prostate(3)|skin(1)	46		Lung NSC(249;0.00188)|all_lung(500;0.00307)|all_neural(839;0.0424)|Breast(839;0.0743)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TGCCCAGAAGGCAAAGCCAGT	0.388000													74	67					0	0	0.870114	0	0
IGHV1OR16-3	28313	broad.mit.edu	37	16	32070612	32070612	+	RNA	SNP	A	A	C			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr16:32070612A>C	ENST00000566806.1	-	0	499																											GGTCTCCTGCAAGGCTTCTGG	0.552000													3	68					0	0	0.115264	0	0
MTPAP	55149	broad.mit.edu	37	10	30638194	30638194	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr10:30638194G>A	ENST00000263063.3	-	1	54	c.11C>T	c.(10-12)cCc>cTc	p.P4L	MTPAP_ENST00000358107.4_Intron|MTPAP_ENST00000488290.1_Intron	NM_018109.3	NP_060579.3	Q9NVV4	PAPD1_HUMAN	mitochondrial poly(A) polymerase	4					cell death|histone mRNA catabolic process|mRNA polyadenylation|transcription, DNA-dependent	mitochondrion	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|protein homodimerization activity|RNA binding|UTP binding			breast(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	33						CCCCACGCCGGGAACCGCCAT	0.567000													3	31					0	0	0.115264	0	0
EEPD1	80820	broad.mit.edu	37	7	36194642	36194642	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr7:36194642G>A	ENST00000242108.4	+	2	1427	c.709G>A	c.(709-711)Ggg>Agg	p.G237R	EEPD1_ENST00000534978.1_Missense_Mutation_p.G237R	NM_030636.2	NP_085139.2	Q7L9B9	EEPD1_HUMAN	endonuclease/exonuclease/phosphatase family domain containing 1	237					DNA repair		DNA binding			endometrium(2)|large_intestine(3)|lung(10)|ovary(1)|pancreas(1)|skin(1)	18						GCCGCCAGGGGGGCCCACCCA	0.662000													8	28					0	0	0.307466	0	0
PDE7A	5150	broad.mit.edu	37	8	66695027	66695027	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr8:66695027G>A	ENST00000401827.3	-	2	633	c.190C>T	c.(190-192)Cgt>Tgt	p.R64C	PDE7A_ENST00000379419.4_Missense_Mutation_p.R38C|PDE7A_ENST00000396642.3_Missense_Mutation_p.R64C	NM_001242318.2	NP_001229247.1	Q13946	PDE7A_HUMAN	phosphodiesterase 7A	64						cell fraction|cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			large_intestine(5)|lung(3)|stomach(1)|urinary_tract(1)	10			Epithelial(68;0.0509)|BRCA - Breast invasive adenocarcinoma(89;0.111)|all cancers(69;0.168)|OV - Ovarian serous cystadenocarcinoma(28;0.238)		Dyphylline(DB00651)|Ketotifen(DB00920)	CCTAGCATACGAATGTATAAT	0.284000													11	15					0	0	0.457914	0	0
APBA3	9546	broad.mit.edu	37	19	3752701	3752701	+	Silent	SNP	C	C	G			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr19:3752701C>G	ENST00000316757.3	-	8	1400	c.1200G>C	c.(1198-1200)cgG>cgC	p.R400R		NM_004886.3	NP_004877.1	O96018	APBA3_HUMAN	amyloid beta (A4) precursor protein-binding, family A, member 3	400	PDZ 1.				intracellular signal transduction|protein transport	intracellular|membrane	protein binding			endometrium(1)|large_intestine(1)|skin(1)	3		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00467)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTCCCCTCGCCGCTTCTCGA	0.746000													6	8					0	0	0.217242	0	0
SPOP	8405	broad.mit.edu	37	17	47688665	47688665	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr17:47688665T>C	ENST00000393331.3	-	8	1105	c.635A>G	c.(634-636)cAg>cGg	p.Q212R	SPOP_ENST00000347630.2_Missense_Mutation_p.Q212R|SPOP_ENST00000504102.1_Missense_Mutation_p.Q212R|SPOP_ENST00000503676.1_Missense_Mutation_p.Q212R|SPOP_ENST00000393328.2_Missense_Mutation_p.Q212R	NM_001007226.1|NM_001007227.1	NP_001007227.1|NP_001007228.1	O43791	SPOP_HUMAN	speckle-type POZ protein	212	BTB.				mRNA processing	nucleus	protein binding			endometrium(18)|kidney(1)|large_intestine(3)|liver(1)|lung(4)|ovary(3)|prostate(33)	63						CTTGTGAGCCTGGAATTCCTG	0.448000										Prostate(2;0.17)			4	201					0	0	0.150653	0	0
KRT6B	3854	broad.mit.edu	37	12	52843354	52843354	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr12:52843354G>A	ENST00000252252.3	-	5	1023	c.976C>T	c.(976-978)Cgc>Tgc	p.R326C		NM_005555.3	NP_005546.2	P04259	K2C6B_HUMAN	keratin 6B	326	Linker 12.|Rod.				ectoderm development	keratin filament	structural constituent of cytoskeleton			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(19)|ovary(4)|prostate(2)	40				BRCA - Breast invasive adenocarcinoma(357;0.083)		TCCAGGTTGCGGTTGTTGTCC	0.527000													4	220					0	0	0.150653	0	0
SYNE1	23345	broad.mit.edu	37	6	152651634	152651634	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr6:152651634G>A	ENST00000367255.5	-	78	14787	c.14186C>T	c.(14185-14187)gCg>gTg	p.A4729V	SYNE1_ENST00000341594.5_Missense_Mutation_p.A4476V|SYNE1_ENST00000448038.1_Missense_Mutation_p.A4658V|SYNE1_ENST00000423061.1_Missense_Mutation_p.A4658V|SYNE1_ENST00000265368.4_Missense_Mutation_p.A4729V	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	4729					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TTCATCCACCGCCTCCCCAAG	0.552000										HNSCC(10;0.0054)			14	42					0	0	0.539581	0	0
ZSCAN5B	342933	broad.mit.edu	37	19	56703238	56703238	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr19:56703238G>C	ENST00000586855.2	-	3	882	c.569C>G	c.(568-570)gCt>gGt	p.A190G	ZSCAN5B_ENST00000358992.3_Missense_Mutation_p.A190G			A6NJL1	ZSA5B_HUMAN	zinc finger and SCAN domain containing 5B	190					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(5)|large_intestine(3)|lung(23)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37						GGACAGTGCAGCGACCCTGGG	0.622000													6	31					0	0	0.248553	0	0
AKAP3	10566	broad.mit.edu	37	12	4735774	4735774	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr12:4735774G>A	ENST00000545990.2	-	5	2818	c.2294C>T	c.(2293-2295)aCg>aTg	p.T765M	AKAP3_ENST00000228850.1_Missense_Mutation_p.T765M	NM_001278309.1	NP_001265238.1	O75969	AKAP3_HUMAN	A kinase (PRKA) anchor protein 3	765					acrosome reaction|cellular component movement	acrosomal vesicle	protein kinase A binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|liver(1)|lung(17)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	51						AACTGTGTCCGTTAGGTTGTG	0.488000													30	126					0	0	0.740014	0	0
ITGB4	3691	broad.mit.edu	37	17	73753345	73753345	+	Silent	SNP	C	C	T			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr17:73753345C>T	ENST00000200181.3	+	39	5470	c.5283C>T	c.(5281-5283)agC>agT	p.S1761S	ITGB4_ENST00000579662.1_Silent_p.S1691S|ITGB4_ENST00000450894.3_Silent_p.S1691S|ITGB4_ENST00000449880.2_Silent_p.S1744S|GALK1_ENST00000225614.2_Intron|ITGB4_ENST00000339591.3_Silent_p.S1744S	NM_000213.3	NP_000204.3	P16144	ITB4_HUMAN	integrin, beta 4	1761					cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|liver(1)|lung(25)|skin(1)|urinary_tract(1)	43	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			GCGAGTACAGCAGCATCACCA	0.667000													16	37					0	0	0.479597	0	0
CKAP5	9793	broad.mit.edu	37	11	46800015	46800015	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr11:46800015C>G	ENST00000529230.1	-	21	2614	c.2568G>C	c.(2566-2568)gaG>gaC	p.E856D	CKAP5_ENST00000312055.5_Missense_Mutation_p.E856D|CKAP5_ENST00000354558.3_Missense_Mutation_p.E856D|CKAP5_ENST00000415402.1_Missense_Mutation_p.E856D			Q14008	CKAP5_HUMAN	cytoskeleton associated protein 5	856					cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding			breast(1)|cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(13)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	43						CCTACCTGATCTCCGTCCTCG	0.413000													23	54					0	0	0.667858	0	0
CCDC178	374864	broad.mit.edu	37	18	30969508	30969508	+	Silent	SNP	A	A	C			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr18:30969508A>C	ENST00000383096.3	-	5	386	c.204T>G	c.(202-204)acT>acG	p.T68T	CCDC178_ENST00000579916.1_Silent_p.T68T|CCDC178_ENST00000583930.1_Silent_p.T68T|CCDC178_ENST00000579947.1_Silent_p.T68T|CCDC178_ENST00000402325.1_Silent_p.T68T|CCDC178_ENST00000403303.1_Silent_p.T68T|CCDC178_ENST00000300227.8_Silent_p.T68T|CCDC178_ENST00000406524.2_Silent_p.T68T					coiled-coil domain containing 178																		CCTCACCTTCAGTATTTGTCA	0.279000													19	43					0	0	0.592651	0	0
XPO7	23039	broad.mit.edu	37	8	21851879	21851879	+	Silent	SNP	T	T	A			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr8:21851879T>A	ENST00000434536.1	+	20	2283	c.2181T>A	c.(2179-2181)acT>acA	p.T727T	XPO7_ENST00000252512.9_Silent_p.T718T|XPO7_ENST00000433566.4_Silent_p.T719T			Q9UIA9	XPO7_HUMAN	exportin 7	718					mRNA transport|protein export from nucleus|transmembrane transport	cytoplasm|nuclear pore	nuclear export signal receptor activity|protein transporter activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(2)|lung(12)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				Colorectal(74;0.0187)|COAD - Colon adenocarcinoma(73;0.0724)		TACAGCGAACTCTAGTTGGCC	0.388000													18	35					0	0	0.575678	0	0
NDNF	79625	broad.mit.edu	37	4	121957686	121957686	+	Silent	SNP	G	G	A	rs146653001		TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr4:121957686G>A	ENST00000379692.4	-	4	1966	c.1440C>T	c.(1438-1440)atC>atT	p.I480I		NM_024574.3	NP_078850.3	Q8TB73	CD031_HUMAN	neuron-derived neurotrophic factor	480	Fibronectin type-III 2.									breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(10)|prostate(3)|skin(1)|urinary_tract(1)	29						CTTTTTTGTAGATGCAAAACT	0.433000													24	67					0	0	0.639603	0	0
WDTC1	23038	broad.mit.edu	37	1	27632707	27632707	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr1:27632707G>A	ENST00000319394.3	+	16	2402	c.1867G>A	c.(1867-1869)Gat>Aat	p.D623N	WDTC1_ENST00000361771.3_Missense_Mutation_p.D622N	NM_001276252.1|NM_015023.3	NP_001263181.1|NP_055838.2	Q8N5D0	WDTC1_HUMAN	WD and tetratricopeptide repeats 1	623							protein binding			central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(5)|ovary(1)|skin(1)	21		all_cancers(24;3.12e-19)|all_epithelial(13;4.18e-18)|Colorectal(325;0.000147)|all_lung(284;0.000366)|Lung NSC(340;0.000548)|Renal(390;0.00211)|Breast(348;0.00257)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0443)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-27)|Colorectal(126;8.83e-09)|COAD - Colon adenocarcinoma(152;1.02e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000544)|KIRC - Kidney renal clear cell carcinoma(1967;0.00201)|STAD - Stomach adenocarcinoma(196;0.00321)|READ - Rectum adenocarcinoma(331;0.0476)		AGTCGTGGAAGATATGGAGGG	0.607000													19	36					0	0	0.557998	0	0
FSCB	84075	broad.mit.edu	37	14	44974032	44974032	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr14:44974032G>A	ENST00000340446.4	-	1	2450	c.2159C>T	c.(2158-2160)cCa>cTa	p.P720L		NM_032135.3	NP_115511.3	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	720						cilium				breast(4)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(10)|lung(47)|ovary(2)|pancreas(1)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	89				GBM - Glioblastoma multiforme(112;0.128)		CAAATCAGCTGGTGGGGAATG	0.522000													11	30					0	0	0.457914	0	0
IGHV3OR16-9	28307	broad.mit.edu	37	16	32077661	32077661	+	RNA	SNP	T	T	C			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr16:32077661T>C	ENST00000354689.6	+	0	276				RP11-1166P10.6_ENST00000566806.1_RNA																							AGGACACGGCTGTGTATTACT	0.552000													7	417					0	0	0.278610	0	0
OBSL1	23363	broad.mit.edu	37	2	220435109	220435109	+	Silent	SNP	C	C	T			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr2:220435109C>T	ENST00000404537.1	-	1	902	c.846G>A	c.(844-846)gaG>gaA	p.E282E	OBSL1_ENST00000289656.3_Intron|OBSL1_ENST00000373876.1_Silent_p.E282E|OBSL1_ENST00000603926.1_Silent_p.E282E|OBSL1_ENST00000373873.4_Silent_p.E282E|INHA_ENST00000489456.1_Intron|OBSL1_ENST00000265318.4_Silent_p.E282E	NM_015311.2	NP_056126.1	O75147	OBSL1_HUMAN	obscurin-like 1	282	Ig-like 3.				cardiac myofibril assembly	intercalated disc|M band|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity						Renal(207;0.0376)		Epithelial(149;2.02e-07)|all cancers(144;1.68e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00834)		GCGGGCGGCCCTCCCAGTGCC	0.672000													10	20					0	0	0.361761	0	0
LINC01250	101927554	broad.mit.edu	37	2	2910678	2910679	+	RNA	INS	-	-	C	rs140675846	by1000genomes	TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr2:2910678_2910679insC	ENST00000457478.1	-	0	594																											caccccctcttcccagcccaca	0.703													4	2	---	---	---	---					
SDHAP1	255812	broad.mit.edu	37	3	195690462	195690463	+	RNA	INS	-	-	G			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr3:195690462_195690463insG	ENST00000427841.1	-	0	2203					NR_003264.2																						catgcgcaacaggggactgtaa	0.366													3	4	---	---	---	---					
HLA-A	3105	broad.mit.edu	37	6	29911160	29911179	+	Frame_Shift_Del	DEL	CCTGCGCTCTTGGACCGCGG	CCTGCGCTCTTGGACCGCGG	-	rs41542714		TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr6:29911160_29911179delCCTGCGCTCTTGGACCGCGG	ENST00000396634.1	+	5	800_819	c.459_478delCCTGCGCTCTTGGACCGCGG	c.(457-480)gacgfs	p.DLRSWTAA153fs	HLA-A_ENST00000376809.5_Frame_Shift_Del_p.DLRSWTAA153fs|HLA-A_ENST00000376802.2_Frame_Shift_Del_p.DLRSWTAA153fs|HLA-A_ENST00000376806.5_Frame_Shift_Del_p.DLRSWTAA153fs			P30443	1A01_HUMAN	major histocompatibility complex, class I, A	153	Alpha-2.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity	p.A160fs*15(1)		central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	30						TGAACGAGGACCTGCGCTCTTGGACCGCGGCGGACATGGC	0.655									Osteosarcoma, Familial Clustering of;Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of;Melanoma, Familial Clustering of;Lichen Sclerosis et Atrophicus, Familial Clustering of	Multiple Myeloma(9;0.094)			14	25	---	---	---	---					
TTLL2	83887	broad.mit.edu	37	6	167754366	167754367	+	Frame_Shift_Ins	INS	-	-	T	rs150247166		TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr6:167754366_167754367insT	ENST00000239587.5	+	3	1066_1067	c.978_979insT	c.(976-981)agttttfs	p.SF326fs		NM_031949.4	NP_114155.4	Q9BWV7	TTLL2_HUMAN	tubulin tyrosine ligase-like family, member 2	326	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity			central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(17)|ovary(1)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	39		Breast(66;7.8e-06)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		CGCTCAGCAGATTTTTTTCCTA	0.446													82	161	---	---	---	---					
RP11-513H8.1	0	broad.mit.edu	37	8	135331910	135331935	+	RNA	DEL	CCAGGGAGAGGGTGTGAGGGGTCAAT	CCAGGGAGAGGGTGTGAGGGGTCAAT	-	rs13271339		TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr8:135331910_135331935delCCAGGGAGAGGGTGTGAGGGGTCAAT	ENST00000523317.1	-	0	84																											CCACAGCAGCCCAGGGAGAGGGTGTGAGGGGTCAATCCAGGGAGAG	0.544													2	4	---	---	---	---					
HERC2P4	100289574	broad.mit.edu	37	16	32126964	32126964	+	RNA	DEL	T	T	-	rs77063499		TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr16:32126964delT	ENST00000564145.1	-	0	456																											TTGCCCCCCCTGCCGCCGCGG	0.692													2	4	---	---	---	---					
EPN2	22905	broad.mit.edu	37	17	19232949	19232950	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr17:19232949_19232950insA	ENST00000314728.5	+	9	1884_1885	c.1400_1401insA	c.(1399-1401)taafs	p.*467fs	EPN2_ENST00000347697.2_Frame_Shift_Ins_p.*410fs|EPN2_ENST00000395626.1_Frame_Shift_Ins_p.*467fs|EPN2_ENST00000395620.2_Frame_Shift_Ins_p.*410fs|EPN2_ENST00000571254.1_Frame_Shift_Ins_p.*403fs|EPN2_ENST00000575595.1_Frame_Shift_Ins_p.*175fs|EPN2_ENST00000395618.3_Frame_Shift_Ins_p.*182fs	NM_014964.4	NP_055779.2	O95208	EPN2_HUMAN	epsin 2	467	6 X 3 AA repeats of [DE]-P-W.				endocytosis		lipid binding	p.T470fs*19(1)		breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(5)|prostate(1)|skin(2)|urinary_tract(1)	19	all_cancers(12;3.11e-05)|all_epithelial(12;0.00121)|Hepatocellular(7;0.00345)|Breast(13;0.143)					CTTCGGACTTCAAAAAAAACAG	0.396													7	139	---	---	---	---					
UPF3AP2	147150	broad.mit.edu	37	17	20279654	20279655	+	RNA	INS	-	-	T			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr17:20279654_20279655insT	ENST00000578315.1	-	0	51_52																											atctgtctctcttttttttttt	0.381													2	4	---	---	---	---					
TBC1D3B	414059	broad.mit.edu	37	17	34499240	34499240	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr17:34499240delC	ENST00000454519.3	-	7	620	c.471delG	c.(469-471)atfs	p.M157fs	CTB-91J4.1_ENST00000592460.1_RNA|TBC1D3B_ENST00000398801.3_Frame_Shift_Del_p.M157fs	NM_001001417.5	NP_001001417.5	A6NDS4	TBC3B_HUMAN	TBC1 domain family, member 3B	157	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			endometrium(2)|lung(3)|pancreas(1)	6		Breast(25;0.102)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CCCTGAAGAACATATGCTTCC	0.562													48	1435	---	---	---	---