Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
OSBPL6	114880	broad.mit.edu	37	2	179247226	179247226	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr2:179247226C>T	ENST00000190611.4	+	16	1989	c.1613C>T	c.(1612-1614)tCt>tTt	p.S538F	OSBPL6_ENST00000359685.3_Missense_Mutation_p.S502F|OSBPL6_ENST00000409045.3_Missense_Mutation_p.S507F|OSBPL6_ENST00000392505.2_Missense_Mutation_p.S563F|OSBPL6_ENST00000357080.4_Missense_Mutation_p.S471F|OSBPL6_ENST00000409631.1_Missense_Mutation_p.S502F|OSBPL6_ENST00000315022.2_Missense_Mutation_p.S542F	NM_032523.3	NP_115912.1	Q9BZF3	OSBL6_HUMAN	oxysterol binding protein-like 6	538					lipid transport		lipid binding	p.S538F(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(13)|lung(18)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	46			OV - Ovarian serous cystadenocarcinoma(117;0.00578)|Epithelial(96;0.00847)|all cancers(119;0.0335)			GACAATATTTCTCGGCAAAGT	0.428000													5	26					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140996236	140996236	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chrX:140996236G>A	ENST00000285879.4	+	4	3332	c.3046G>A	c.(3046-3048)Gag>Aag	p.E1016K	MAGEC1_ENST00000406005.2_Missense_Mutation_p.E83K	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	1016	MAGE.						protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					CTATGCCTCTGAGGAGGTCAT	0.547000										HNSCC(15;0.026)			4	78					0	0	1	0	0
BYSL	705	broad.mit.edu	37	6	41897915	41897915	+	Silent	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr6:41897915G>A	ENST00000230340.4	+	3	852	c.477G>A	c.(475-477)caG>caA	p.Q159Q		NM_004053.3	NP_004044.3	Q13895	BYST_HUMAN	bystin-like	159					cell adhesion|female pregnancy|ribosome biogenesis	cytoplasm|nucleolus				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(5)|skin(1)	8	Colorectal(47;0.121)		STAD - Stomach adenocarcinoma(11;0.000204)|Epithelial(12;0.000473)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CTGAGAAGCAGACAGAGGTTG	0.602000													10	85					0	0	1	0	0
PARP14	54625	broad.mit.edu	37	3	122437494	122437494	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr3:122437494G>A	ENST00000474629.2	+	14	4762	c.4496G>A	c.(4495-4497)gGa>gAa	p.G1499E	PARP14_ENST00000475640.1_3'UTR	NM_017554.2	NP_060024.2	Q460N5	PAR14_HUMAN	poly (ADP-ribose) polymerase family, member 14	1499				G -> A (in Ref. 1; AAN08627).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	NAD+ ADP-ribosyltransferase activity			NS(2)|breast(5)|cervix(2)|endometrium(7)|kidney(5)|large_intestine(8)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	50				GBM - Glioblastoma multiforme(114;0.0531)		AAGGTTTTGGGAATTAGCAGA	0.413000													52	247					0	0	1	0	0
LDB3	11155	broad.mit.edu	37	10	88459051	88459051	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr10:88459051G>A	ENST00000372056.4	+	8	1140	c.1117G>A	c.(1117-1119)Gaa>Aaa	p.E373K	LDB3_ENST00000458213.2_Intron|LDB3_ENST00000372066.3_Missense_Mutation_p.E258K|LDB3_ENST00000542786.1_3'UTR|LDB3_ENST00000310944.6_Missense_Mutation_p.E305K|LDB3_ENST00000263066.6_Intron|LDB3_ENST00000429277.2_Intron|LDB3_ENST00000361373.4_Intron|LDB3_ENST00000352360.5_Intron	NM_001171611.1	NP_001165082.1	O75112	LDB3_HUMAN	LIM domain binding 3	0						cytoskeleton|perinuclear region of cytoplasm|pseudopodium	zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|soft_tissue(1)	25						GTTTGAAACGGAACGTAACAG	0.483000													41	164					0	0	1	0	0
CLCN7	1186	broad.mit.edu	37	16	1501640	1501640	+	Silent	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr16:1501640G>A	ENST00000382745.4	-	16	2036	c.1431C>T	c.(1429-1431)ctC>ctT	p.L477L	CLCN7_ENST00000448525.1_Silent_p.L453L|CLCN7_ENST00000262318.8_Silent_p.L453L	NM_001287.5	NP_001278.1	P51798	CLCN7_HUMAN	chloride channel, voltage-sensitive 7	477						integral to membrane|lysosomal membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			breast(2)|central_nervous_system(3)|endometrium(3)|kidney(3)|large_intestine(2)|lung(8)|ovary(1)|skin(2)	24		Hepatocellular(780;0.0893)				GGTCGTGGAAGAGGCTCACCA	0.637000													4	28					0	0	1	0	0
SRRM2	23524	broad.mit.edu	37	16	2815912	2815912	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr16:2815912C>T	ENST00000301740.8	+	11	5932	c.5383C>T	c.(5383-5385)Cag>Tag	p.Q1795*		NM_016333.3	NP_057417.3	Q9UQ35	SRRM2_HUMAN	serine/arginine repetitive matrix 2	1795	Arg-rich.|Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|lung(34)|ovary(6)|pancreas(3)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(7)	105						TGGATCTTCTCAGTCAACCTC	0.602000													20	58					0	0	1	0	0
ENOX1	55068	broad.mit.edu	37	13	43930251	43930251	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr13:43930251C>G	ENST00000261488.6	-	8	1204	c.627G>C	c.(625-627)aaG>aaC	p.K209N	ENOX1_ENST00000540032.1_Missense_Mutation_p.K22N|ENOX1_ENST00000412891.1_Missense_Mutation_p.K209N	NM_001242863.1|NM_017993.3	NP_001229792.1|NP_060463.2	Q8TC92	ENOX1_HUMAN	ecto-NOX disulfide-thiol exchanger 1	209	RRM.				electron transport chain|rhythmic process|transport	extracellular space|plasma membrane	nucleic acid binding|nucleotide binding|oxidoreductase activity			breast(1)|endometrium(3)|large_intestine(7)|lung(18)|pancreas(2)|prostate(1)|skin(1)|urinary_tract(1)	34		Lung NSC(96;0.000518)|Prostate(109;0.0233)|Hepatocellular(98;0.0268)|Lung SC(185;0.0367)|Breast(139;0.0406)		GBM - Glioblastoma multiforme(144;0.00333)|BRCA - Breast invasive adenocarcinoma(63;0.172)		GGCCTGAATCCTTTTTGTCGG	0.532000													14	53					0	0	1	0	0
ANLN	54443	broad.mit.edu	37	7	36462273	36462273	+	Silent	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr7:36462273G>A	ENST00000265748.2	+	14	2552	c.2331G>A	c.(2329-2331)ttG>ttA	p.L777L	ANLN_ENST00000396068.2_Silent_p.L740L	NM_018685.2	NP_061155.2	Q9NQW6	ANLN_HUMAN	anillin, actin binding protein	777	Localization to the cleavage furrow.				cytokinesis|mitosis|regulation of exit from mitosis|septin ring assembly	actomyosin contractile ring|nucleus	actin binding			breast(2)|endometrium(5)|kidney(5)|large_intestine(9)|lung(17)|ovary(2)|prostate(3)|skin(2)	45						TTGATGAATTGAATAAATTGA	0.348000													14	61					0	0	1	0	0
GBP1	2633	broad.mit.edu	37	1	89520433	89520433	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr1:89520433C>G	ENST00000370473.4	-	10	1816	c.1597G>C	c.(1597-1599)Gag>Cag	p.E533Q	GBP1_ENST00000484970.1_5'UTR	NM_002053.2	NP_002044.2	P32455	GBP1_HUMAN	guanylate binding protein 1, interferon-inducible	533					interferon-gamma-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			endometrium(7)|kidney(4)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	30		Lung NSC(277;0.123)		all cancers(265;0.0156)|Epithelial(280;0.0291)		TCCATCTTCTCAGTCAGTTGT	0.438000													5	503					0	0	1	0	0
GABRB2	2561	broad.mit.edu	37	5	160973365	160973365	+	Silent	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr5:160973365C>T	ENST00000274547.2	-	3	349	c.132G>A	c.(130-132)ctG>ctA	p.L44L	GABRB2_ENST00000353437.6_Silent_p.L44L|GABRB2_ENST00000520240.1_Silent_p.L44L|GABRB2_ENST00000517901.1_Intron|GABRB2_ENST00000393959.1_Silent_p.L44L|GABRB2_ENST00000517547.1_Intron	NM_000813.2|NM_021911.2	NP_000804.1|NP_068711.1	P47870	GBRB2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 2	44					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|GABA-A receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|liver(1)|lung(9)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	26	Renal(175;0.00259)	Medulloblastoma(196;0.021)|all_neural(177;0.0463)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	CATAGCCTTTCAGGAGTCTAT	0.453000													11	49					0	0	1	0	0
SCN9A	6335	broad.mit.edu	37	2	167056284	167056284	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr2:167056284C>T	ENST00000375387.4	-	27	5208	c.4868G>A	c.(4867-4869)cGt>cAt	p.R1623H	AC010127.3_ENST00000447809.2_RNA|SCN9A_ENST00000409672.1_Missense_Mutation_p.R1611H|SCN9A_ENST00000409435.1_Missense_Mutation_p.R1622H|SCN9A_ENST00000303354.6_Missense_Mutation_p.R1623H			Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha subunit	1622						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(5)|central_nervous_system(6)|endometrium(6)|kidney(3)|large_intestine(27)|lung(38)|ovary(6)|prostate(8)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	108					Lamotrigine(DB00555)|Lidocaine(DB00281)	TTTGACTAGACGTAGGATTCG	0.498000													38	139					0	0	1	0	0
ARID1B	57492	broad.mit.edu	37	6	157150436	157150436	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr6:157150436C>T	ENST00000346085.5	+	2	1619	c.1618C>T	c.(1618-1620)Cag>Tag	p.Q540*	ARID1B_ENST00000350026.5_Nonsense_Mutation_p.Q540*|ARID1B_ENST00000367148.1_Nonsense_Mutation_p.Q540*|ARID1B_ENST00000275248.4_Nonsense_Mutation_p.Q482*	NM_020732.3	NP_065783.3	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	540					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			NS(2)|breast(5)|central_nervous_system(4)|endometrium(12)|kidney(4)|large_intestine(11)|lung(30)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(3)	81		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		TTCTCAGCCTCAGCAGAGCAG	0.567000													9	115					0	0	1	0	0
DNMBP	23268	broad.mit.edu	37	10	101639929	101639929	+	Missense_Mutation	SNP	G	G	A	rs148968752		TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr10:101639929G>A	ENST00000342239.3	-	16	4350	c.4259C>T	c.(4258-4260)tCg>tTg	p.S1420L	DNMBP_ENST00000543621.1_Missense_Mutation_p.S642L|DNMBP_ENST00000324109.4_Missense_Mutation_p.S1396L|DNMBP_ENST00000540316.1_Missense_Mutation_p.S332L			Q6XZF7	DNMBP_HUMAN	dynamin binding protein	1396	Ser-rich.				intracellular signal transduction|regulation of Rho protein signal transduction	cell junction|cytoskeleton|Golgi stack|synapse	protein binding|Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|cervix(4)|endometrium(9)|large_intestine(14)|lung(19)|ovary(5)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	61		Colorectal(252;0.234)		Epithelial(162;2.94e-10)|all cancers(201;3.15e-08)		GCAAGACCCCGAGGTAAAGGA	0.557000													46	188					0	0	1	0	0
TTF2	8458	broad.mit.edu	37	1	117618364	117618364	+	Silent	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr1:117618364C>T	ENST00000369466.3	+	5	1202	c.1158C>T	c.(1156-1158)ttC>ttT	p.F386F		NM_003594.3	NP_003585.3	Q9UNY4	TTF2_HUMAN	transcription termination factor, RNA polymerase II	386					mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|termination of RNA polymerase II transcription	cytoplasm|spliceosomal complex|transcription elongation factor complex	ATP binding|ATP-dependent helicase activity|DNA binding|DNA-dependent ATPase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|liver(1)|lung(24)|ovary(1)|prostate(2)|skin(2)|urinary_tract(2)	50	Lung SC(450;0.225)	all_cancers(81;4.23e-06)|all_epithelial(167;3.65e-07)|all_lung(203;2.81e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0553)|Colorectal(144;0.179)|LUSC - Lung squamous cell carcinoma(189;0.19)		ACCTCCAATTCCCTGATCGAA	0.502000													6	38					0	0	1	0	0
ZNF609	23060	broad.mit.edu	37	15	64968080	64968080	+	Silent	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr15:64968080G>A	ENST00000326648.3	+	4	3155	c.3027G>A	c.(3025-3027)caG>caA	p.Q1009Q		NM_015042.1	NP_055857.1	O15014	ZN609_HUMAN	zinc finger protein 609	1009						nucleus	zinc ion binding			breast(3)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(9)|lung(11)|ovary(1)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						AAGAACAGCAGAAACGCCAGA	0.562000													39	148					0	0	1	0	0
AHSG	197	broad.mit.edu	37	3	186338451	186338451	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr3:186338451C>T	ENST00000411641.2	+	7	1055	c.836C>T	c.(835-837)cCg>cTg	p.P279L	AHSG_ENST00000273784.5_Missense_Mutation_p.P280L			P02765	FETUA_HUMAN	alpha-2-HS-glycoprotein	279					acute-phase response|negative regulation of bone mineralization|negative regulation of insulin receptor signaling pathway|pinocytosis|positive regulation of phagocytosis|regulation of inflammatory response|skeletal system development	extracellular space	cysteine-type endopeptidase inhibitor activity|protein binding			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(15)|prostate(2)|stomach(1)	22	all_cancers(143;3.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.27e-20)	GBM - Glioblastoma multiforme(93;0.0463)		GATGCACCTCCGTCCCCTCCA	0.622000													5	252					0	0	1	0	0
SKA3	221150	broad.mit.edu	37	13	21742369	21742369	+	Silent	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr13:21742369G>A	ENST00000314759.5	-	4	625	c.501C>T	c.(499-501)atC>atT	p.I167I	SKA3_ENST00000400018.3_Silent_p.I167I	NM_145061.5	NP_659498.4	Q8IX90	SKA3_HUMAN	spindle and kinetochore associated complex subunit 3	167					cell division|chromosome segregation|mitosis|regulation of microtubule polymerization or depolymerization	condensed chromosome outer kinetochore|cytoplasm|spindle microtubule	protein binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	19						CTTGGGATACGATGTACCGCT	0.438000													37	123					0	0	1	0	0
C21orf91	54149	broad.mit.edu	37	21	19169339	19169339	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr21:19169339C>T	ENST00000284881.4	-	3	314	c.224G>A	c.(223-225)cGa>cAa	p.R75Q	C21orf91_ENST00000493464.1_5'UTR|C21orf91_ENST00000400559.3_Missense_Mutation_p.R75Q|AL109761.5_ENST00000428689.1_RNA|C21orf91_ENST00000400558.3_Missense_Mutation_p.R75Q	NM_001100420.1|NM_017447.3	NP_001093890.1|NP_059143.3	Q9NYK6	EURL_HUMAN	chromosome 21 open reading frame 91	75										endometrium(2)|large_intestine(2)|lung(4)|ovary(1)	9				Epithelial(23;8.76e-05)|all cancers(11;0.000422)|OV - Ovarian serous cystadenocarcinoma(11;0.0107)|Lung(58;0.0129)|COAD - Colon adenocarcinoma(22;0.0303)|LUSC - Lung squamous cell carcinoma(23;0.0381)|Colorectal(24;0.0929)		AAGCTTAGATCGAGGACAACC	0.363000													11	56					0	0	1	0	0
GRIP1	23426	broad.mit.edu	37	12	66814548	66814548	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr12:66814548C>T	ENST00000359742.4	-	15	2030	c.1790G>A	c.(1789-1791)gGa>gAa	p.G597E	GRIP1_ENST00000286445.7_Missense_Mutation_p.G597E|GRIP1_ENST00000398016.3_Missense_Mutation_p.G545E			Q9Y3R0	GRIP1_HUMAN	glutamate receptor interacting protein 1	597	PDZ 5.				androgen receptor signaling pathway|intracellular signal transduction|positive regulation of transcription, DNA-dependent|synaptic transmission	cell junction|cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|postsynaptic membrane	androgen receptor binding|beta-catenin binding|protein C-terminus binding|receptor signaling complex scaffold activity|transcription coactivator activity			NS(3)|breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(19)|ovary(2)|prostate(2)|skin(1)	50			GBM - Glioblastoma multiforme(2;0.00069)	GBM - Glioblastoma multiforme(28;0.0933)		GAGGGGGTCTCCTGGTTTTCT	0.368000													17	101					0	0	1	0	0
ZNF562	54811	broad.mit.edu	37	19	9764512	9764512	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr19:9764512C>T	ENST00000448622.1	-	6	556	c.394G>A	c.(394-396)Gag>Aag	p.E132K	ZNF562_ENST00000537617.1_Missense_Mutation_p.E16K|ZNF562_ENST00000453792.2_Missense_Mutation_p.E63K|ZNF562_ENST00000541032.1_Missense_Mutation_p.E95K|ZNF562_ENST00000293648.4_Missense_Mutation_p.E60K|ZNF562_ENST00000590155.1_Missense_Mutation_p.E131K|ZNF562_ENST00000453372.2_Missense_Mutation_p.E132K|ZNF562_ENST00000587392.1_3'UTR	NM_001130031.1|NM_001130032.1	NP_001123503.1|NP_001123504.1	Q6V9R5	ZN562_HUMAN	zinc finger protein 562	132					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	17						CTGAAGACCTCTCCACAATTC	0.403000													15	74					0	0	1	0	0
C7orf60	154743	broad.mit.edu	37	7	112555465	112555465	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr7:112555465C>G	ENST00000297145.4	-	2	363	c.198G>C	c.(196-198)gaG>gaC	p.E66D	C7orf60_ENST00000485446.1_5'UTR	NM_152556.2	NP_689769.2	Q1RMZ1	CG060_HUMAN	chromosome 7 open reading frame 60	66										breast(1)|endometrium(2)|lung(7)|ovary(3)|prostate(2)|skin(1)|urinary_tract(1)	17						TTTCTTCATCCTCACAGTGTT	0.363000													12	65					0	0	1	0	0
PRPF8	10594	broad.mit.edu	37	17	1561562	1561562	+	Silent	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr17:1561562C>T	ENST00000572621.1	-	33	5755	c.5490G>A	c.(5488-5490)caG>caA	p.Q1830Q	PRPF8_ENST00000304992.6_Silent_p.Q1830Q			Q6P2Q9	PRP8_HUMAN	pre-mRNA processing factor 8	1830	Involved in interaction with pre-mRNA 5' splice site.					catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(13)|lung(24)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	77				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		CCAAACGCTTCTGTCCCGCCC	0.493000													15	65					0	0	1	0	0
FANCD2	2177	broad.mit.edu	37	3	10084814	10084814	+	Silent	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr3:10084814G>A	ENST00000287647.3	+	12	1062	c.969G>A	c.(967-969)ttG>ttA	p.L323L	FANCD2_ENST00000419585.1_Silent_p.L323L|FANCD2_ENST00000383807.1_Silent_p.L323L|FANCD2_ENST00000383806.1_Silent_p.L323L	NM_033084.3	NP_149075.2	Q9BXW9	FACD2_HUMAN	Fanconi anemia, complementation group D2	323	Interaction with BRCA2.				DNA repair|response to gamma radiation	nucleoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	51				OV - Ovarian serous cystadenocarcinoma(96;0.148)		AAGTAAAGTTGAAAAGTAAAG	0.413000			"""D, Mis, N, F"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				17	52					0	0	1	0	0
IGKV3D-11	28876	broad.mit.edu	37	2	90212193	90212193	+	RNA	SNP	C	C	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr2:90212193C>A	ENST00000390277.2	+	0	382																											CTCTCACCATCAGCAGCCTAG	0.527000													20	119					3.51602e-12	3.67784e-12	1	1	0
HNF4A	3172	broad.mit.edu	37	20	43043163	43043163	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr20:43043163C>G	ENST00000316099.3	+	5	598	c.509C>G	c.(508-510)tCc>tGc	p.S170C	HNF4A_ENST00000457232.1_Missense_Mutation_p.S148C|HNF4A_ENST00000415691.1_Missense_Mutation_p.S170C|HNF4A_ENST00000443598.2_Missense_Mutation_p.S170C	NM_000457.4|NM_001258355.1	NP_000448.3|NP_001245284.1	P41235	HNF4A_HUMAN	hepatocyte nuclear factor 4, alpha	170					blood coagulation|endocrine pancreas development|glucose homeostasis|negative regulation of cell growth|negative regulation of cell proliferation|ornithine metabolic process|phospholipid homeostasis|positive regulation of cholesterol homeostasis|regulation of growth hormone receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to glucose stimulus|triglyceride homeostasis|xenobiotic metabolic process	cytoplasm	activating transcription factor binding|protein homodimerization activity|receptor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(4)|large_intestine(7)|lung(17)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(2)	34		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			TCCCCCGTCTCCGGGATCAAC	0.597000													22	64					0	0	1	0	0
RIC8A	60626	broad.mit.edu	37	11	212415	212415	+	Splice_Site	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr11:212415G>A	ENST00000526104.1	+	6	2313		c.e6-1		RIC8A_ENST00000325207.5_Splice_Site|RIC8A_ENST00000527696.1_Splice_Site			Q9NPQ8	RIC8A_HUMAN	RIC8 guanine nucleotide exchange factor A							cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(3)|pancreas(1)|prostate(1)|skin(1)	13		all_cancers(49;9.23e-07)|all_epithelial(84;0.000315)|Breast(177;0.00122)|Ovarian(85;0.0202)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.45e-27)|Epithelial(43;2.94e-26)|OV - Ovarian serous cystadenocarcinoma(40;5.86e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.105)|LUSC - Lung squamous cell carcinoma(625;0.122)		ATCCTCTACAGACACACAGGC	0.572000													4	20					0	0	1	0	0
TMEM168	64418	broad.mit.edu	37	7	112407287	112407287	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr7:112407287C>T	ENST00000312814.5	-	5	2619	c.2059G>A	c.(2059-2061)Gac>Aac	p.D687N	TMEM168_ENST00000454074.1_Missense_Mutation_p.D687N	NM_022484.4	NP_071929.3	Q9H0V1	TM168_HUMAN	transmembrane protein 168	687						integral to membrane|transport vesicle				breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(10)|lung(12)|ovary(1)|prostate(2)|stomach(1)	32						TGTCCTGTGTCCAGCACAGTA	0.378000													14	47					0	0	1	0	0
HIVEP1	3096	broad.mit.edu	37	6	12122457	12122457	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr6:12122457C>T	ENST00000379388.2	+	4	2761	c.2429C>T	c.(2428-2430)cCg>cTg	p.P810L		NM_002114.2	NP_002105.2	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer binding protein 1	810					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(11)|liver(1)|lung(31)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	90	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				TCTGATATACCGAAGTCACCT	0.398000													4	138					0	0	1	0	0
POSTN	10631	broad.mit.edu	37	13	38160373	38160373	+	Silent	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr13:38160373G>A	ENST00000379747.4	-	7	915	c.798C>T	c.(796-798)gaC>gaT	p.D266D	POSTN_ENST00000379749.4_Silent_p.D266D|POSTN_ENST00000541481.1_Silent_p.D266D|POSTN_ENST00000541179.1_Silent_p.D266D|POSTN_ENST00000379742.4_Silent_p.D266D|POSTN_ENST00000379743.4_Silent_p.D266D	NM_006475.2	NP_006466.2	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor	266	FAS1 2.				cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(16)|lung(22)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	59		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		TGAAGTGACCGTCTCTTCCAA	0.458000													18	64					0	0	1	0	0
HIPK3	10114	broad.mit.edu	37	11	33308479	33308479	+	Silent	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr11:33308479G>A	ENST00000303296.4	+	2	824	c.519G>A	c.(517-519)caG>caA	p.Q173Q	HIPK3_ENST00000379016.3_Silent_p.Q173Q|HIPK3_ENST00000525975.1_Silent_p.Q173Q|HIPK3_ENST00000456517.1_Silent_p.Q173Q	NM_005734.3	NP_005725.3	Q9H422	HIPK3_HUMAN	homeodomain interacting protein kinase 3	173					anti-apoptosis|apoptosis|negative regulation of JUN kinase activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm	ATP binding|protein serine/threonine kinase activity			endometrium(3)|kidney(3)|large_intestine(9)|liver(4)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	39						GATCAAAACAGAATTGTACCA	0.418000													19	51					0	0	1	0	0
LARGE	9215	broad.mit.edu	37	22	33700301	33700301	+	Silent	SNP	G	G	A	rs113253213	byFrequency	TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr22:33700301G>A	ENST00000354992.2	-	13	2215	c.1644C>T	c.(1642-1644)aaC>aaT	p.N548N	LARGE_ENST00000437602.2_Silent_p.N548N|LARGE_ENST00000452586.2_Silent_p.N347N|LARGE_ENST00000397394.2_Silent_p.N548N|LARGE_ENST00000337431.2_Silent_p.N496N|LARGE_ENST00000402320.1_Silent_p.N496N	NM_004737.4	NP_004728.1	O95461	LARGE_HUMAN	like-glycosyltransferase	548					glycosphingolipid biosynthetic process|muscle cell homeostasis|N-acetylglucosamine metabolic process|protein glycosylation	integral to Golgi membrane	acetylglucosaminyltransferase activity			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(23)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	51		Lung NSC(1;0.219)				TCATGGCCACGTTGCGCAGCA	0.562000													27	104					0	0	1	0	0
DSN1	79980	broad.mit.edu	37	20	35381201	35381201	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr20:35381201G>C	ENST00000426836.1	-	11	1433	c.1061C>G	c.(1060-1062)tCt>tGt	p.S354C	DSN1_ENST00000473615.1_5'UTR|DSN1_ENST00000448110.1_Missense_Mutation_p.S338C|DSN1_ENST00000373734.4_Missense_Mutation_p.S247C|DSN1_ENST00000373740.3_Missense_Mutation_p.S282C|DSN1_ENST00000373745.3_Missense_Mutation_p.S354C|DSN1_ENST00000373750.4_Missense_Mutation_p.S354C	NM_001145316.1	NP_001138788.1	Q9H410	DSN1_HUMAN	DSN1, MIS12 kinetochore complex component	354					cell division|chromosome segregation|mitotic prometaphase	cytosol|MIS12/MIND type complex|nucleus	protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	16		Myeloproliferative disorder(115;0.00874)				TCACTGACAAGATCCAGATCC	0.498000													21	83					0	0	1	0	0
CACNA1A	773	broad.mit.edu	37	19	13346065	13346065	+	Silent	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr19:13346065C>T	ENST00000360228.5	-	33	5090	c.5091G>A	c.(5089-5091)ctG>ctA	p.L1697L	CACNA1A_ENST00000573710.2_Silent_p.L1698L|CACNA1A_ENST00000574822.1_5'UTR	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	1698					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	GCATGGCGATCAGCAGACAGA	0.562000											OREG0025293	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	17					0	0	1	0	0
SLC4A2	6522	broad.mit.edu	37	7	150773105	150773105	+	Silent	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr7:150773105G>A	ENST00000485713.1	+	22	4517	c.3477G>A	c.(3475-3477)cgG>cgA	p.R1159R	SLC4A2_ENST00000461735.1_Silent_p.R1145R|SLC4A2_ENST00000310317.5_Silent_p.R1077R|SLC4A2_ENST00000413384.2_Silent_p.R1159R|SLC4A2_ENST00000392826.2_Silent_p.R1150R|RP11-148K1.12_ENST00000485974.1_RNA	NM_001199692.1	NP_001186621.1	P04920	B3A2_HUMAN	solute carrier family 4 (anion exchanger), member 2	1159	Membrane (anion exchange).				bicarbonate transport	integral to membrane|membrane fraction	inorganic anion exchanger activity			NS(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(2)|liver(2)|lung(14)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	33			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CCCAGGTCCGGACCCTCCGTA	0.652000													16	62					0	0	1	0	0
ABL2	27	broad.mit.edu	37	1	179086512	179086512	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr1:179086512C>G	ENST00000502732.1	-	8	1566	c.1363G>C	c.(1363-1365)Gag>Cag	p.E455Q	ABL2_ENST00000512653.1_Missense_Mutation_p.E440Q|ABL2_ENST00000392043.3_Missense_Mutation_p.E434Q|ABL2_ENST00000511413.1_Missense_Mutation_p.E455Q|ABL2_ENST00000367623.4_Missense_Mutation_p.E434Q|ABL2_ENST00000344730.3_Missense_Mutation_p.E440Q|ABL2_ENST00000504405.1_Missense_Mutation_p.E419Q|ABL2_ENST00000507173.1_Missense_Mutation_p.E434Q|ABL2_ENST00000408940.3_Missense_Mutation_p.E419Q	NM_001168236.1|NM_001168237.1|NM_001168238.1|NM_007314.3	NP_001161708.1|NP_001161709.1|NP_001161710.1|NP_009298.1	P42684	ABL2_HUMAN	c-abl oncogene 2, non-receptor tyrosine kinase	455	Protein kinase.				axon guidance|cell adhesion|peptidyl-tyrosine phosphorylation|positive regulation of oxidoreductase activity|signal transduction	cytoskeleton|cytosol	ATP binding|magnesium ion binding|manganese ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(8)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	65					Adenosine triphosphate(DB00171)|Dasatinib(DB01254)	GCAAGACTCTCTGGTGCTGTC	0.383000			T	ETV6	AML								21	113					0	0	1	0	0
KIF21A	55605	broad.mit.edu	37	12	39756911	39756911	+	Silent	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr12:39756911G>A	ENST00000395670.3	-	7	1427	c.1008C>T	c.(1006-1008)ctC>ctT	p.L336L	KIF21A_ENST00000361418.5_Silent_p.L336L|KIF21A_ENST00000544797.2_Silent_p.L336L|KIF21A_ENST00000541463.2_Silent_p.L336L|KIF21A_ENST00000361961.3_Silent_p.L336L			Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	336					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity	p.L336L(1)		NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(41)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	86		Lung NSC(34;0.179)|all_lung(34;0.213)				TATTACCCCCGAGGGAATCCT	0.378000													19	73					0	0	1	0	0
PARP8	79668	broad.mit.edu	37	5	50111356	50111356	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr5:50111356C>T	ENST00000281631.5	+	15	1824	c.1666C>T	c.(1666-1668)Cag>Tag	p.Q556*	PARP8_ENST00000514067.2_Nonsense_Mutation_p.Q556*|PARP8_ENST00000514342.2_Nonsense_Mutation_p.Q309*|PARP8_ENST00000511363.2_3'UTR|PARP8_ENST00000505697.2_Nonsense_Mutation_p.Q556*|PARP8_ENST00000505554.1_Nonsense_Mutation_p.Q535*|PARP8_ENST00000503750.2_Nonsense_Mutation_p.Q556*	NM_001178056.1|NM_024615.3	NP_001171527.1|NP_078891.2	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	556						intracellular	NAD+ ADP-ribosyltransferase activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(23)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Lung NSC(810;0.0305)|Breast(144;0.222)				AACTGGAGCTCAGGTAGTAAC	0.378000													7	29					0	0	1	0	0
FRG1BP	284802	broad.mit.edu	37	20	29628243	29628243	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr20:29628243T>C	ENST00000278882.3	+	6	625	c.245T>C	c.(244-246)tTg>tCg	p.L82S	FRG1B_ENST00000439954.2_Missense_Mutation_p.L87S|FRG1B_ENST00000358464.4_Missense_Mutation_p.L82S														p.L82S(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ATGGCTTTGTTGGCCTCAAAT	0.363000													4	157					0	0	1	0	0
ZNF521	25925	broad.mit.edu	37	18	22804669	22804669	+	Silent	SNP	G	G	C			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr18:22804669G>C	ENST00000361524.3	-	4	3361	c.3213C>G	c.(3211-3213)ctC>ctG	p.L1071L	ZNF521_ENST00000584787.1_Silent_p.L851L|ZNF521_ENST00000538137.2_Silent_p.L1071L	NM_015461.2	NP_056276.1	Q96K83	ZN521_HUMAN	zinc finger protein 521	1071					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding	p.L1071L(1)		NS(1)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(21)|lung(97)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	149	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					GGAATTCTTTGAGGCAAGATG	0.522000			T	PAX5	ALL								21	65					0	0	1	0	0
NF1	4763	broad.mit.edu	37	17	29556273	29556273	+	Silent	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr17:29556273G>A	ENST00000358273.4	+	21	3023	c.2640G>A	c.(2638-2640)gtG>gtA	p.V880V	NF1_ENST00000356175.3_Silent_p.V880V	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1	880					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(4)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		TGATTTCAGTGATGTCTTCAG	0.483000			"""D, Mis, N, F, S, O"""		"""neurofibroma, glioma"""	"""neurofibroma, glioma"""			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			33	99					0	0	1	0	0
ATF4	468	broad.mit.edu	37	22	39918485	39918485	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr22:39918485G>C	ENST00000337304.2	+	2	1816	c.934G>C	c.(934-936)Gag>Cag	p.E312Q	ATF4_ENST00000404241.2_Missense_Mutation_p.E312Q|ATF4_ENST00000396680.1_Missense_Mutation_p.E312Q	NM_001675.2	NP_001666.2	P18848	ATF4_HUMAN	activating transcription factor 4	312	Interaction with GABBR1 (By similarity).|Leucine-zipper.				cellular amino acid metabolic process|gluconeogenesis|positive regulation of transcription from RNA polymerase II promoter|response to endoplasmic reticulum stress|transcription from RNA polymerase II promoter	cytoplasm|plasma membrane	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(2)|large_intestine(2)|lung(5)|skin(1)	11	Melanoma(58;0.04)					TGAGTGCAAAGAGCTGGAAAA	0.502000													9	24					0	0	1	0	0
FGFR1OP2	26127	broad.mit.edu	37	12	27116343	27116343	+	Silent	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr12:27116343C>T	ENST00000229395.3	+	6	921	c.579C>T	c.(577-579)gaC>gaT	p.D193D	FGFR1OP2_ENST00000327214.5_Silent_p.D155D	NM_015633.2	NP_056448.1	Q9NVK5	FGOP2_HUMAN	FGFR1 oncogene partner 2	193						cytoplasm				cervix(1)|large_intestine(4)|lung(1)|prostate(2)	8	Colorectal(261;0.0847)					TTGAAATTGACGAGCAACAGG	0.388000													10	40					0	0	1	0	0
TUBGCP4	27229	broad.mit.edu	37	15	43668716	43668716	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr15:43668716C>T	ENST00000564079.1	+	3	463	c.223C>T	c.(223-225)Caa>Taa	p.Q75*	TUBGCP4_ENST00000570081.1_3'UTR|TUBGCP4_ENST00000260383.7_Nonsense_Mutation_p.Q75*	NM_014444.2	NP_055259.2	Q9UGJ1	GCP4_HUMAN	tubulin, gamma complex associated protein 4	75					G2/M transition of mitotic cell cycle|microtubule nucleation|protein complex assembly	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	structural constituent of cytoskeleton			breast(1)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(4)|prostate(2)|upper_aerodigestive_tract(2)	21		all_cancers(109;1.27e-10)|all_epithelial(112;4.82e-09)|Lung NSC(122;1.72e-06)|all_lung(180;1.59e-05)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;3.53e-07)		CCATCCATCTCAACAGGGCCA	0.473000											OREG0023088	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	68					0	0	1	0	0
NDST4	64579	broad.mit.edu	37	4	115751020	115751020	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr4:115751020G>A	ENST00000264363.2	-	13	3103	c.2425C>T	c.(2425-2427)Caa>Taa	p.Q809*		NM_022569.1	NP_072091.1	Q9H3R1	NDST4_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4	809	Heparan sulfate N-sulfotransferase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(43)|ovary(1)|prostate(7)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	81		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		TCCAGTAATTGACACCAAAAA	0.348000													14	28					0	0	1	0	0
HUWE1	10075	broad.mit.edu	37	X	53560286	53560286	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chrX:53560286C>T	ENST00000342160.3	-	83	13566	c.13109G>A	c.(13108-13110)gGc>gAc	p.G4370D	HUWE1_ENST00000262854.6_Missense_Mutation_p.G4370D			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	4370	HECT.				base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						CAGCCCAAAGCCTTCAGAGCA	0.488000													3	6					0	0	1	0	0
NHP2L1	4809	broad.mit.edu	37	22	42070954	42070954	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr22:42070954C>T	ENST00000401959.1	-	4	686	c.370G>A	c.(370-372)Gaa>Aaa	p.E124K	NHP2L1_ENST00000355257.3_Missense_Mutation_p.E124K|NHP2L1_ENST00000463675.1_5'UTR|NHP2L1_ENST00000215956.5_Missense_Mutation_p.E124K|NHP2L1_ENST00000402458.1_Missense_Mutation_p.E128K	NM_005008.3	NP_004999.1	P55769	NH2L1_HUMAN	NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)	124					nuclear mRNA splicing, via spliceosome|ribosome biogenesis	box C/D snoRNP complex|nucleoplasm|spliceosomal complex	protein binding|RNA binding			endometrium(1)|kidney(1)|lung(1)|prostate(1)	4						AAGAGCCTTTCAATGGACTGC	0.512000													4	88					0	0	1	0	0
NIPBL	25836	broad.mit.edu	37	5	37051937	37051937	+	Silent	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr5:37051937G>A	ENST00000282516.8	+	41	7510	c.7011G>A	c.(7009-7011)aaG>aaA	p.K2337K	NIPBL_ENST00000448238.2_Silent_p.K2337K	NM_015384.4|NM_133433.3	NP_056199.2|NP_597677.2	Q6KC79	NIPBL_HUMAN	Nipped-B homolog (Drosophila)	2337					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			autonomic_ganglia(1)|breast(4)|endometrium(9)|kidney(22)|large_intestine(21)|liver(1)|lung(47)|ovary(7)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	128	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			TGCGGAACAAGGCTGATCAGC	0.318000													11	44					0	0	1	0	0
TLR5	7100	broad.mit.edu	37	1	223285720	223285720	+	Silent	SNP	T	T	C			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr1:223285720T>C	ENST00000540964.1	-	4	1115	c.654A>G	c.(652-654)aaA>aaG	p.K218K	TLR5_ENST00000342210.6_Silent_p.K218K			O60602	TLR5_HUMAN	toll-like receptor 5	218					cellular response to mechanical stimulus|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of toll-like receptor signaling pathway	integral to membrane|plasma membrane	interleukin-1 receptor binding|transmembrane receptor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	32				GBM - Glioblastoma multiforme(131;0.0851)		GGTTCATACATTTTCCCCAGT	0.458000													14	87					0	0	1	0	0
ZCCHC16	340595	broad.mit.edu	37	X	111698734	111698734	+	Nonsense_Mutation	SNP	C	C	T	rs139116920	byFrequency	TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chrX:111698734C>T	ENST00000340433.2	+	1	1008	c.778C>T	c.(778-780)Cga>Tga	p.R260*		NM_001004308.2	NP_001004308.2	Q6ZR62	ZCH16_HUMAN	zinc finger, CCHC domain containing 16	260							nucleic acid binding|zinc ion binding	p.R260G(1)		cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	27						TATACAGCTGCGAGAAGGCCA	0.552000													47	114					0	0	1	0	0
TMEM215	401498	broad.mit.edu	37	9	32784684	32784684	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr9:32784684C>T	ENST00000342743.5	+	2	868	c.503C>T	c.(502-504)tCg>tTg	p.S168L		NM_212558.2	NP_997723.2	Q68D42	TM215_HUMAN	transmembrane protein 215	168						integral to membrane				endometrium(4)|kidney(1)|large_intestine(3)|lung(2)|prostate(2)	12						TACTGCCCCTCGGGCAGTTCC	0.587000													11	44					0	0	1	0	0
CNTNAP1	8506	broad.mit.edu	37	17	40845455	40845455	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr17:40845455C>T	ENST00000264638.4	+	18	3110	c.2893C>T	c.(2893-2895)Cgg>Tgg	p.R965W	CTD-3193K9.3_ENST00000592440.1_RNA	NM_003632.2	NP_003623.1	P78357	CNTP1_HUMAN	contactin associated protein 1	965	EGF-like 2.				axon guidance|cell adhesion	paranode region of axon	receptor activity|receptor binding|SH3 domain binding|SH3/SH2 adaptor activity			NS(1)|breast(4)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(11)|lung(15)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.143)		TGCCCACCCTCGGCTCCCCTG	0.612000													26	108					0	0	1	0	0
GRAMD1A	57655	broad.mit.edu	37	19	35501007	35501007	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr19:35501007G>A	ENST00000599564.1	+	6	669	c.598G>A	c.(598-600)Gcc>Acc	p.A200T	GRAMD1A_ENST00000424536.2_Missense_Mutation_p.A113T|GRAMD1A_ENST00000411896.2_Missense_Mutation_p.A106T|GRAMD1A_ENST00000504615.2_5'UTR|GRAMD1A_ENST00000317991.5_Missense_Mutation_p.A113T|GRAMD1A_ENST00000598073.1_3'UTR			Q96CP6	GRM1A_HUMAN	GRAM domain containing 1A	113						integral to membrane				NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	19	all_lung(56;2.66e-08)|Lung NSC(56;4.13e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			TTACTCCTGCGCCCTGCAGCG	0.652000													5	142					0	0	1	0	0
NR1H2	7376	broad.mit.edu	37	19	50881514	50881514	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr19:50881514T>C	ENST00000253727.5	+	5	525	c.290T>C	c.(289-291)tTc>tCc	p.F97S	NR1H2_ENST00000598168.1_Missense_Mutation_p.F97S|NR1H2_ENST00000593926.1_Missense_Mutation_p.F97S|NR1H2_ENST00000411902.2_Intron|NR1H2_ENST00000599105.1_Missense_Mutation_p.F97S|NR1H2_ENST00000542413.1_5'UTR	NM_007121.5	NP_009052.3	P55055	NR1H2_HUMAN	nuclear receptor subfamily 1, group H, member 2	97					negative regulation of cholesterol storage|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of lipid transport|negative regulation of pinocytosis|negative regulation of transcription, DNA-dependent|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of triglyceride biosynthetic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			endometrium(2)|large_intestine(1)|lung(3)|upper_aerodigestive_tract(2)	8		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00757)|GBM - Glioblastoma multiforme(134;0.0186)		GCCTCCGGCTTCCACTACAAC	0.657000													58	258					0	0	1	0	0
RNF144A	9781	broad.mit.edu	37	2	7179775	7179775	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr2:7179775G>T	ENST00000320892.6	+	9	1205	c.763G>T	c.(763-765)Gca>Tca	p.A255S	RNF144A_ENST00000467276.1_3'UTR	NM_014746.3	NP_055561.2	P50876	R144A_HUMAN	ring finger protein 144A	255						Golgi apparatus|integral to membrane	ligase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(15)|ovary(1)|prostate(1)	25	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)	all_cancers(51;0.226)		OV - Ovarian serous cystadenocarcinoma(76;0.195)		GGGCATTTTTGCAGGATTTGG	0.507000													28	121					9.65963e-10	9.97896e-10	1	1	0
PPFIA3	8541	broad.mit.edu	37	19	49643235	49643235	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr19:49643235C>G	ENST00000334186.4	+	18	2607	c.2258C>G	c.(2257-2259)tCt>tGt	p.S753C	PPFIA3_ENST00000602351.1_Missense_Mutation_p.S753C	NM_003660.2	NP_003651.1	O75145	LIPA3_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3	753						cell surface|cytoplasm	protein binding			NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(16)|pancreas(1)|prostate(1)|skin(4)|urinary_tract(1)	35		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.36e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000203)|GBM - Glioblastoma multiforme(486;0.00307)|Epithelial(262;0.00677)		ACCCCAGATTCTCTGCACAAA	0.562000													34	99					0	0	1	0	0
NIPBL	25836	broad.mit.edu	37	5	37051941	37051941	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr5:37051941G>A	ENST00000282516.8	+	41	7514	c.7015G>A	c.(7015-7017)Gat>Aat	p.D2339N	NIPBL_ENST00000448238.2_Missense_Mutation_p.D2339N	NM_015384.4|NM_133433.3	NP_056199.2|NP_597677.2	Q6KC79	NIPBL_HUMAN	Nipped-B homolog (Drosophila)	2339					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			autonomic_ganglia(1)|breast(4)|endometrium(9)|kidney(22)|large_intestine(21)|liver(1)|lung(47)|ovary(7)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	128	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			GAACAAGGCTGATCAGCAACT	0.323000													11	45					0	0	1	0	0
CLIC6	54102	broad.mit.edu	37	21	36081714	36081714	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr21:36081714C>G	ENST00000360731.3	+	6	1831	c.1831C>G	c.(1831-1833)Ctg>Gtg	p.L611V	CLIC6_ENST00000349499.2_Missense_Mutation_p.L593V			Q96NY7	CLIC6_HUMAN	chloride intracellular channel 6	611	GST C-terminal.					chloride channel complex|cytoplasm|plasma membrane	voltage-gated chloride channel activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(2)|lung(2)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	19						AAATAGCCCTCTGCCTGATGA	0.468000													5	64					0	0	1	0	0
LIMS1	3987	broad.mit.edu	37	2	109276203	109276203	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr2:109276203G>A	ENST00000393310.1	+	2	306	c.139G>A	c.(139-141)Gaa>Aaa	p.E47K	LIMS1_ENST00000409441.1_Missense_Mutation_p.E84K|LIMS1_ENST00000544547.1_Missense_Mutation_p.E59K|LIMS1_ENST00000332345.6_Missense_Mutation_p.E47K|LIMS1_ENST00000338045.3_Missense_Mutation_p.E47K|LIMS1_ENST00000542845.1_Missense_Mutation_p.E109K|LIMS1_ENST00000393314.2_Missense_Mutation_p.E109K|LIMS1_ENST00000462817.1_3'UTR|LIMS1_ENST00000410093.1_Missense_Mutation_p.E51K	NM_001193488.1	NP_001180417.1	P48059	LIMS1_HUMAN	LIM and senescent cell antigen-like domains 1	47	LIM zinc-binding 1.				cell aging|cell junction assembly|cellular response to transforming growth factor beta stimulus|negative regulation of transcription, DNA-dependent	cytosol|focal adhesion|perinuclear region of cytoplasm	protein binding|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)	10						GCAGTTCCCAGAAGGACTCTT	0.577000													13	50					0	0	1	0	0
CAPN3	825	broad.mit.edu	37	15	42694331	42694331	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr15:42694331G>C	ENST00000397163.3	+	12	1753	c.1534G>C	c.(1534-1536)Gag>Cag	p.E512Q	CAPN3_ENST00000357568.3_Missense_Mutation_p.E512Q|CAPN3_ENST00000356316.3_Missense_Mutation_p.E425Q|CAPN3_ENST00000349748.3_Missense_Mutation_p.E464Q|RP11-164J13.1_ENST00000495723.1_RNA|CAPN3_ENST00000318023.7_Intron	NM_000070.2	NP_000061.1	P20807	CAN3_HUMAN	calpain 3, (p94)	512	Domain III.				muscle organ development|proteolysis	cytoplasm	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(21)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	47		all_cancers(109;1.65e-16)|all_epithelial(112;8.34e-15)|Lung NSC(122;3.56e-09)|all_lung(180;1.68e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;7.36e-07)		GGTTCCCAAAGAGGTATAGCA	0.572000													4	162					0	0	1	0	0
HPS4	89781	broad.mit.edu	37	22	26860540	26860540	+	Silent	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr22:26860540G>A	ENST00000398145.2	-	11	1672	c.1056C>T	c.(1054-1056)ctC>ctT	p.L352L	HPS4_ENST00000402105.3_Silent_p.L347L|HPS4_ENST00000336873.5_Silent_p.L352L|HPS4_ENST00000398141.1_Silent_p.L365L	NM_022081.4	NP_071364.4	Q9NQG7	HPS4_HUMAN	Hermansky-Pudlak syndrome 4	352					lysosome organization|positive regulation of eye pigmentation|protein stabilization|protein targeting	lysosome|melanosome|membrane fraction|platelet dense granule	protein homodimerization activity			breast(2)|endometrium(3)|kidney(5)|large_intestine(4)|lung(12)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	32						GGGAGGAGCTGAGGCCAAGAA	0.552000									Hermansky-Pudlak syndrome				20	88					0	0	1	0	0
SAMD14	201191	broad.mit.edu	37	17	48195580	48195580	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr17:48195580C>T	ENST00000330175.4	-	3	472	c.155G>A	c.(154-156)cGg>cAg	p.R52Q	SAMD14_ENST00000503734.1_5'UTR|SAMD14_ENST00000503131.1_Missense_Mutation_p.R52Q	NM_001257359.1	NP_001244288.1	Q8IZD0	SAM14_HUMAN	sterile alpha motif domain containing 14	52										breast(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(3)|prostate(1)|urinary_tract(1)	15						GGCACTGTCCCGAAGCCTGGA	0.642000													26	87					0	0	1	0	0
RNMTL1	55178	broad.mit.edu	37	17	686360	686360	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr17:686360G>A	ENST00000304478.4	+	2	458	c.352G>A	c.(352-354)Gaa>Aaa	p.E118K		NM_018146.2	NP_060616.1	Q9HC36	RMTL1_HUMAN	RNA methyltransferase like 1	118					RNA processing		protein binding|RNA binding|RNA methyltransferase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	10				UCEC - Uterine corpus endometrioid carcinoma (25;0.0219)		GCCATTTCGGGAAAAACAAGG	0.423000													16	71					0	0	1	0	0
STXBP5L	9515	broad.mit.edu	37	3	121126200	121126200	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr3:121126200G>A	ENST00000273666.6	+	24	3041	c.2770G>A	c.(2770-2772)Gaa>Aaa	p.E924K	STXBP5L_ENST00000472879.1_Missense_Mutation_p.E900K|STXBP5L_ENST00000492541.1_Missense_Mutation_p.E924K|STXBP5L_ENST00000471454.1_Missense_Mutation_p.E900K|STXBP5L_ENST00000497029.1_Missense_Mutation_p.E898K	NM_014980.2	NP_055795.1	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	924					exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(12)|lung(28)|ovary(7)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				GBM - Glioblastoma multiforme(114;0.0694)		CAACATAGATGAAAATGAAAA	0.393000													6	50					0	0	1	0	0
SSSCA1	10534	broad.mit.edu	37	11	65338432	65338432	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr11:65338432G>A	ENST00000531405.1	+	2	372	c.136G>A	c.(136-138)Gat>Aat	p.D46N	SSSCA1_ENST00000527920.1_Missense_Mutation_p.D46N|SSSCA1_ENST00000309328.3_Missense_Mutation_p.D83N|SSSCA1_ENST00000526877.1_Silent_p.K77K			O60232	SSA27_HUMAN	Sjogren syndrome/scleroderma autoantigen 1	83					cell division|mitosis		protein binding			kidney(1)|lung(4)|ovary(1)|prostate(1)|skin(1)	8						CGTGGATAAAGATAATCCCGG	0.522000													11	29					0	0	1	0	0
SCN9A	6335	broad.mit.edu	37	2	167055739	167055739	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr2:167055739C>T	ENST00000375387.4	-	27	5753	c.5413G>A	c.(5413-5415)Gat>Aat	p.D1805N	AC010127.3_ENST00000447809.2_RNA|SCN9A_ENST00000409672.1_Missense_Mutation_p.D1793N|SCN9A_ENST00000409435.1_Missense_Mutation_p.D1804N|SCN9A_ENST00000303354.6_Missense_Mutation_p.D1805N			Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha subunit	1804						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(5)|central_nervous_system(6)|endometrium(6)|kidney(3)|large_intestine(27)|lung(38)|ovary(6)|prostate(8)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	108					Lamotrigine(DB00555)|Lidocaine(DB00281)	GCTGCAAAATCAGAGAGTTTA	0.473000													35	114					0	0	1	0	0
DOPEY2	9980	broad.mit.edu	37	21	37603425	37603425	+	Silent	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr21:37603425G>A	ENST00000399151.3	+	14	2428	c.2343G>A	c.(2341-2343)caG>caA	p.Q781Q		NM_005128.2	NP_005119.2	Q9Y3R5	DOP2_HUMAN	dopey family member 2	781					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(6)|lung(25)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						CGCTCTTCCAGCTGCCAGGTG	0.587000													22	70					0	0	1	0	0
CACNB3	784	broad.mit.edu	37	12	49219232	49219232	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr12:49219232C>T	ENST00000301050.2	+	8	788	c.589C>T	c.(589-591)Cag>Tag	p.Q197*	CACNB3_ENST00000540990.1_Nonsense_Mutation_p.Q184*|CACNB3_ENST00000547392.1_Nonsense_Mutation_p.Q170*|CACNB3_ENST00000547230.1_Nonsense_Mutation_p.Q156*|CACNB3_ENST00000536187.2_Nonsense_Mutation_p.Q196*	NM_000725.3	NP_000716.2	P54284	CACB3_HUMAN	calcium channel, voltage-dependent, beta 3 subunit	197					axon guidance|membrane depolarization|synaptic transmission	cytosol|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			autonomic_ganglia(1)|breast(1)|large_intestine(5)|lung(4)|prostate(1)	12					Verapamil(DB00661)	AGACATGATGCAGAAGGCTCT	0.567000													4	119					0	0	1	0	0
CENPF	1063	broad.mit.edu	37	1	214815174	214815174	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr1:214815174G>C	ENST00000366955.3	+	12	3661	c.3493G>C	c.(3493-3495)Gaa>Caa	p.E1165Q		NM_016343.3	NP_057427.3	P49454	CENPF_HUMAN	centromere protein F, 350/400kDa	1237					cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			NS(2)|breast(2)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(37)|lung(47)|ovary(7)|prostate(3)|skin(6)|stomach(1)|urinary_tract(1)	126				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		GACTAAACATGAATGTCAAAA	0.318000													17	54					0	0	1	0	0
LPPR5	163404	broad.mit.edu	37	1	99418842	99418842	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr1:99418842G>C	ENST00000370188.3	-	3	765	c.405C>G	c.(403-405)atC>atG	p.I135M	LPPR5_ENST00000263177.4_Missense_Mutation_p.I135M	NM_001010861.2	NP_001010861.1	Q32ZL2	LPPR5_HUMAN		135						integral to membrane	hydrolase activity										CATTTACAAAGATATCTGTAG	0.408000													11	62					0	0	1	0	0
SLC35E3	55508	broad.mit.edu	37	12	69140553	69140553	+	Silent	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr12:69140553C>T	ENST00000398004.2	+	1	668	c.396C>T	c.(394-396)ctC>ctT	p.L132L		NM_018656.2	NP_061126.2	Q7Z769	S35E3_HUMAN	solute carrier family 35, member E3	132						integral to membrane				cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	12	Breast(13;2.31e-06)|Renal(347;0.0684)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00372)			GAATCCAGCTCACGCTGGTGA	0.582000													31	126					0	0	1	0	0
MROH5	389690	broad.mit.edu	37	8	142446099	142446099	+	RNA	SNP	C	C	G			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr8:142446099C>G	ENST00000606664.1	+	0	1455				MROH5_ENST00000430863.1_RNA																							CCGCTCAGCTCCCTGTCTGCC	0.687000													6	58					0	0	1	0	0
ABCG4	64137	broad.mit.edu	37	11	119031274	119031274	+	Silent	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr11:119031274C>T	ENST00000307417.3	+	14	1987	c.1623C>T	c.(1621-1623)acC>acT	p.T541T	ABCG4_ENST00000449422.2_Silent_p.T541T|ABCG4_ENST00000531739.1_Silent_p.T541T	NM_022169.4	NP_071452.2	Q9H172	ABCG4_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 4	541	ABC transmembrane type-2.				cholesterol efflux	integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity|protein homodimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(28)|ovary(2)|prostate(1)|skin(1)	44	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		GCCCAGTTACCGCCATCCCTG	0.567000													6	338					0	0	1	0	0
ARHGAP15	55843	broad.mit.edu	37	2	143959724	143959724	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr2:143959724C>T	ENST00000409869.1	+	4	364	c.187C>T	c.(187-189)Cat>Tat	p.H63Y	ARHGAP15_ENST00000295095.6_Missense_Mutation_p.H63Y			Q53QZ3	RHG15_HUMAN	Rho GTPase activating protein 15	63					regulation of cell shape|small GTPase mediated signal transduction	cytosol|membrane	protein binding|Rac GTPase activator activity			endometrium(1)|kidney(5)|large_intestine(8)|liver(2)|lung(15)|ovary(1)|skin(2)	34				BRCA - Breast invasive adenocarcinoma(221;0.151)		CAGAAGGAATCATTCACAGCA	0.299000													15	54					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32752454	32752454	+	Silent	SNP	C	C	G			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr13:32752454C>G	ENST00000380250.3	+	21	3058	c.2562C>G	c.(2560-2562)ctC>ctG	p.L854L		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	854					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		CCTGGGTCCTCTGCCTCTTCA	0.547000													5	148					0	0	1	0	0
RARG	5916	broad.mit.edu	37	12	53621202	53621202	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr12:53621202C>A	ENST00000425354.2	-	3	615	c.128G>T	c.(127-129)aGc>aTc	p.S43I	RARG_ENST00000543762.1_Intron|RARG_ENST00000327550.3_Intron|RARG_ENST00000394426.1_Missense_Mutation_p.S43I	NM_000966.5	NP_000957.1	P13631	RARG_HUMAN	retinoic acid receptor, gamma	43	Modulating.				canonical Wnt receptor signaling pathway|embryonic eye morphogenesis|embryonic hindlimb morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|regulation of cell size|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid	integral to membrane|transcription factor complex	retinoic acid receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(6)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	GAAGCTAGGGCTCAGCATCTC	0.632000													14	55					6.72482e-11	6.97596e-11	1	1	0
CHFR	55743	broad.mit.edu	37	12	133435802	133435802	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr12:133435802C>G	ENST00000266880.7	-	8	862	c.799G>C	c.(799-801)Gac>Cac	p.D267H	CHFR_ENST00000443047.2_Missense_Mutation_p.D175H|CHFR_ENST00000315585.7_Missense_Mutation_p.D226H|CHFR_ENST00000450056.2_Missense_Mutation_p.D255H|CHFR_ENST00000541837.2_5'UTR|CHFR_ENST00000432561.2_Missense_Mutation_p.D267H			Q96EP1	CHFR_HUMAN	checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase	267					cell division|mitosis|mitotic cell cycle checkpoint|modification-dependent protein catabolic process|protein polyubiquitination	PML body	nucleotide binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding	p.D226N(1)		breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;0.00552)|all_epithelial(31;0.226)		OV - Ovarian serous cystadenocarcinoma(86;2.59e-08)|Epithelial(86;6.38e-07)|all cancers(50;1.56e-05)		CCGTTCAGGTCAAGGTCCCCA	0.552000													25	115					0	0	1	0	0
HPD	3242	broad.mit.edu	37	12	122277703	122277703	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr12:122277703G>C	ENST00000543163.1	-	15	1441	c.996C>G	c.(994-996)ttC>ttG	p.F332L	HPD_ENST00000289004.4_Missense_Mutation_p.F371L	NM_001171993.1	NP_001165464.1	P32754	HPPD_HUMAN	4-hydroxyphenylpyruvate dioxygenase	371					L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	4-hydroxyphenylpyruvate dioxygenase activity|metal ion binding			breast(1)|cervix(1)|kidney(1)|large_intestine(6)|lung(8)|urinary_tract(1)	18	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000105)|Epithelial(86;0.000352)|BRCA - Breast invasive adenocarcinoma(302;0.225)	Nitisinone(DB00348)	GCTCCTCCTCGAAAGCCTTGA	0.602000													21	94					0	0	1	0	0
FAM209A	200232	broad.mit.edu	37	20	55100096	55100096	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr20:55100096G>C	ENST00000371328.3	+	1	555	c.232G>C	c.(232-234)Gac>Cac	p.D78H	GCNT7_ENST00000243913.4_Intron|FAM209A_ENST00000481560.1_3'UTR	NM_001012971.3	NP_001012989.2			family with sequence similarity 209, member A																		GTGTCAAAGAGACAGTGAGAA	0.453000													25	109					0	0	1	0	0
SEC16B	89866	broad.mit.edu	37	1	177915616	177915616	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr1:177915616C>T	ENST00000308284.6	-	14	1803	c.1714G>A	c.(1714-1716)Gtg>Atg	p.V572M	SEC16B_ENST00000464631.1_Missense_Mutation_p.V573M|RP4-798P15.3_ENST00000528461.1_3'UTR|RP4-798P15.3_ENST00000354921.2_5'UTR	NM_033127.2	NP_149118.2	Q96JE7	SC16B_HUMAN	SEC16 homolog B (S. cerevisiae)	572					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane				central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(7)|lung(14)|ovary(3)|skin(1)|stomach(1)	35						CCAAAGGGCACGTGAGCCATG	0.562000											OREG0014008	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	9					0	0	1	0	0
SAMD14	201191	broad.mit.edu	37	17	48195607	48195607	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr17:48195607C>T	ENST00000330175.4	-	3	445	c.128G>A	c.(127-129)aGa>aAa	p.R43K	SAMD14_ENST00000503734.1_5'UTR|SAMD14_ENST00000503131.1_Missense_Mutation_p.R43K	NM_001257359.1	NP_001244288.1	Q8IZD0	SAM14_HUMAN	sterile alpha motif domain containing 14	43										breast(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(3)|prostate(1)|urinary_tract(1)	15						TGGCCGGTGTCTCCGGCCCTT	0.657000													24	76					0	0	1	0	0
ARHGAP21	57584	broad.mit.edu	37	10	24874616	24874616	+	Silent	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr10:24874616C>T	ENST00000396432.2	-	26	5088	c.4602G>A	c.(4600-4602)caG>caA	p.Q1534Q		NM_020824.3	NP_065875.3	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	1533					signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(17)|lung(21)|ovary(7)|pancreas(1)|prostate(5)|skin(2)|stomach(2)|urinary_tract(1)	78						GGGAGGACTTCTGTGCCAGAA	0.522000													6	194					0	0	1	0	0
UGT3A1	133688	broad.mit.edu	37	5	35968190	35968190	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr5:35968190G>A	ENST00000274278.3	-	3	599	c.242C>T	c.(241-243)tCa>tTa	p.S81L	UGT3A1_ENST00000503189.1_Missense_Mutation_p.S81L|UGT3A1_ENST00000507113.1_Missense_Mutation_p.S47L|UGT3A1_ENST00000513233.1_Intron|UGT3A1_ENST00000333811.4_Missense_Mutation_p.S27L	NM_152404.3	NP_689617.3	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	81						integral to membrane	glucuronosyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|skin(4)	46	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			ATCTTCAGGTGAAAACCACCT	0.318000													6	27					0	0	1	0	0
PNMA5	114824	broad.mit.edu	37	X	152159374	152159374	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chrX:152159374C>G	ENST00000439251.1	-	2	1207	c.769G>C	c.(769-771)Gag>Cag	p.E257Q	PNMA5_ENST00000361887.5_Missense_Mutation_p.E257Q|PNMA5_ENST00000452693.1_Missense_Mutation_p.E257Q|PNMA5_ENST00000535214.1_Missense_Mutation_p.E257Q	NM_001103150.1	NP_001096620.1	Q96PV4	PNMA5_HUMAN	paraneoplastic Ma antigen family member 5	257					apoptosis					breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(6)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25	Acute lymphoblastic leukemia(192;6.56e-05)					GAGACTTTCTCTCCAATCTTC	0.522000													32	67					0	0	1	0	0
DNASE1	1773	broad.mit.edu	37	16	3707065	3707065	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr16:3707065G>A	ENST00000246949.5	+	6	3711	c.502G>A	c.(502-504)Gct>Act	p.A168T	DNASE1_ENST00000414110.2_Intron|DNASE1_ENST00000407479.1_Missense_Mutation_p.A168T	NM_005223.3	NP_005214.2	P24855	DNAS1_HUMAN	deoxyribonuclease I	168					apoptosis|DNA catabolic process	extracellular region|nuclear envelope	actin binding|deoxyribonuclease I activity			lung(1)	1		Ovarian(90;0.0261)		Kidney(780;0.0556)	Dornase Alfa(DB00003)	CGAGATCGACGCTCTCTATGA	0.642000													11	46					0	0	1	0	0
SRP54	6729	broad.mit.edu	37	14	35477865	35477865	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr14:35477865G>C	ENST00000556994.1	+	7	790	c.393G>C	c.(391-393)aaG>aaC	p.K131N	SRP54_ENST00000555557.1_Missense_Mutation_p.K67N|SRP54_ENST00000546080.1_Missense_Mutation_p.K82N|SRP54_ENST00000216774.6_Missense_Mutation_p.K131N			P61011	SRP54_HUMAN	signal recognition particle 54kDa	131	G-domain.				GTP catabolic process|response to drug|SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition|SRP-dependent cotranslational protein targeting to membrane, translocation	cytosol|nuclear speck|signal recognition particle, endoplasmic reticulum targeting	7S RNA binding|drug binding|endoplasmic reticulum signal peptide binding|GDP binding|GTP binding|nucleoside-triphosphatase activity|ribonucleoprotein binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	14	Breast(36;0.0545)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;2.48e-05)|Lung(238;3.13e-05)|Epithelial(34;0.0314)|all cancers(34;0.0797)|BRCA - Breast invasive adenocarcinoma(188;0.243)	GBM - Glioblastoma multiforme(112;0.0396)		AAGGTTGGAAGACCTGTTTAA	0.269000													8	40					0	0	1	0	0
PSG4	5672	broad.mit.edu	37	19	43699348	43699348	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr19:43699348C>T	ENST00000405312.3	-	4	1024	c.787G>A	c.(787-789)Gaa>Aaa	p.E263K	PSG4_ENST00000244295.9_Intron|PSG4_ENST00000433626.2_Missense_Mutation_p.E170K	NM_002780.3	NP_002771.2	Q00888	PSG4_HUMAN	pregnancy specific beta-1-glycoprotein 4	263	Ig-like C2-type 2.				defense response|female pregnancy	extracellular region				central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(10)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	24		Prostate(69;0.00682)				CTCTTAGGTTCACAGGTGAAG	0.453000													63	255					0	0	1	0	0
SUOX	6821	broad.mit.edu	37	12	56397864	56397864	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr12:56397864C>T	ENST00000394109.3	+	3	1415	c.691C>T	c.(691-693)Cgc>Tgc	p.R231C	SUOX_ENST00000394115.2_Missense_Mutation_p.R231C|SUOX_ENST00000356124.4_Missense_Mutation_p.R231C|SUOX_ENST00000266971.3_Missense_Mutation_p.R231C|SUOX_ENST00000548274.1_Missense_Mutation_p.R231C|SUOX_ENST00000551841.2_Intron			P51687	SUOX_HUMAN	sulfite oxidase	231	Molybdenum-pterin domain (By similarity).					mitochondrial intermembrane space	electron carrier activity|molybdenum ion binding|sulfite oxidase activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(6)	15			UCEC - Uterine corpus endometrioid carcinoma (6;0.0471)|OV - Ovarian serous cystadenocarcinoma(18;0.119)			AGACACCTATCGCTTACACGT	0.532000													6	71					0	0	1	0	0
SLC25A36	55186	broad.mit.edu	37	3	140695131	140695131	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr3:140695131G>T	ENST00000446041.2	+	7	994	c.769G>T	c.(769-771)Gga>Tga	p.G257*	SLC25A36_ENST00000453248.2_Nonsense_Mutation_p.G232*|SLC25A36_ENST00000324194.6_Nonsense_Mutation_p.G258*	NM_001104647.1|NM_018155.2	NP_001098117.1|NP_060625.2	Q96CQ1	S2536_HUMAN	solute carrier family 25 (pyrimidine nucleotide carrier ), member 36	258					response to estradiol stimulus|transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			endometrium(2)|large_intestine(2)|lung(1)|upper_aerodigestive_tract(1)	6						ACGTGAAGAGGGAACAAAATA	0.343000													8	32					1.12685e-05	1.14517e-05	1	1	0
CCNK	8812	broad.mit.edu	37	14	99961945	99961945	+	Silent	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr14:99961945C>T	ENST00000389879.5	+	4	513	c.390C>T	c.(388-390)ggC>ggT	p.G130G	CCNK_ENST00000555049.1_Silent_p.G130G|CCNK_ENST00000557165.1_3'UTR	NM_001099402.1	NP_001092872.1	O75909	CCNK_HUMAN	cyclin K	130					cell division|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein kinase binding			NS(1)|endometrium(2)|lung(3)	6		all_cancers(154;0.224)|all_epithelial(191;0.0643)|Melanoma(154;0.0866)				TACAATTTGGCCAGTTTGGAG	0.383000													4	112					0	0	1	0	0
TP73-AS1	57212	broad.mit.edu	37	1	3662748	3662748	+	RNA	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr1:3662748G>A	ENST00000452079.1	-	0	1138				TP73-AS1_ENST00000423764.1_RNA|TP73-AS1_ENST00000544565.1_RNA|TP73-AS1_ENST00000418088.1_RNA	NR_033711.1																						CGAGGCGGCTGAGCTGGACAA	0.577000													4	48					0	0	1	0	0
TAOK2	9344	broad.mit.edu	37	16	29997849	29997849	+	Silent	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr16:29997849G>A	ENST00000308893.4	+	16	3299	c.2256G>A	c.(2254-2256)ccG>ccA	p.P752P	TAOK2_ENST00000543033.1_Intron|TAOK2_ENST00000279394.3_Intron|TAOK2_ENST00000416441.2_Silent_p.P579P	NM_001252043.1|NM_016151.3	NP_001238972.1|NP_057235.2	Q9UL54	TAOK2_HUMAN	TAO kinase 2	752					actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|large_intestine(5)|lung(8)|ovary(1)|prostate(3)|skin(1)	22						AGCGCCCCCCGGGCCTTCCAC	0.652000													4	167					0	0	1	0	0
TNFRSF9	3604	broad.mit.edu	37	1	7995117	7995117	+	Missense_Mutation	SNP	G	G	A	rs145966863	byFrequency	TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr1:7995117G>A	ENST00000377507.3	-	6	666	c.500C>T	c.(499-501)cCg>cTg	p.P167L		NM_001561.5	NP_001552.2	Q07011	TNR9_HUMAN	tumor necrosis factor receptor superfamily, member 9	167					induction of apoptosis|negative regulation of cell proliferation	integral to plasma membrane	binding|receptor activity	p.P167L(1)		NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	19	Ovarian(185;0.0634)|all_lung(157;0.151)	all_epithelial(116;9.63e-21)|all_lung(118;1.29e-06)|Lung NSC(185;7.5e-06)|Renal(390;0.000147)|Breast(348;0.000625)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;2.93e-71)|GBM - Glioblastoma multiforme(8;3.72e-37)|Colorectal(212;7e-08)|COAD - Colon adenocarcinoma(227;7.71e-06)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000419)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00103)|READ - Rectum adenocarcinoma(331;0.0649)		GGATGCTCCCGGAGAGAGGTC	0.542000													14	32					0	0	1	0	0
ATP2A1	487	broad.mit.edu	37	16	28900216	28900216	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr16:28900216C>G	ENST00000395503.4	+	9	1221	c.1037C>G	c.(1036-1038)tCt>tGt	p.S346C	ATP2A1_ENST00000357084.3_Missense_Mutation_p.S346C|ATP2A1_ENST00000536376.1_Missense_Mutation_p.S221C	NM_004320.4	NP_004311.1	O14983	AT2A1_HUMAN	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	346					apoptosis in response to endoplasmic reticulum stress|apoptotic mitochondrial changes|ATP biosynthetic process|calcium ion import|elevation of endoplasmic reticulum calcium ion concentration|elevation of mitochondrial calcium ion concentration|maintenance of mitochondrion location|negative regulation of striated muscle contraction|platelet activation|positive regulation of fast-twitch skeletal muscle fiber contraction|reduction of endoplasmic reticulum calcium ion concentration|relaxation of skeletal muscle|response to endoplasmic reticulum stress	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|H zone|I band|microsome|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum|sarcoplasmic reticulum membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|protein homodimerization activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(10)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(2)	38						GGCTGCACCTCTGTCATCTGT	0.592000													58	215					0	0	1	0	0
NOV	4856	broad.mit.edu	37	8	120429126	120429126	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr8:120429126C>G	ENST00000259526.3	+	2	454	c.227C>G	c.(226-228)tCa>tGa	p.S76*		NM_002514.3	NP_002505.1	P48745	NOV_HUMAN	nephroblastoma overexpressed	76	IGFBP N-terminal.				regulation of cell growth		growth factor activity|insulin-like growth factor binding			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(7)|ovary(2)|pancreas(1)|skin(3)	21	all_cancers(13;3.84e-26)|Lung NSC(37;1.19e-08)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.000507)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GAGAGCTGCTCAGATCTGGAG	0.682000											OREG0018940	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	33					0	0	1	0	0
COL22A1	169044	broad.mit.edu	37	8	139845345	139845345	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr8:139845345C>G	ENST00000303045.6	-	5	1228	c.782G>C	c.(781-783)aGa>aCa	p.R261T	COL22A1_ENST00000435777.1_Missense_Mutation_p.R261T	NM_152888.1	NP_690848.1	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	261	TSP N-terminal.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			TCCATTCTCTCTCTTCCCCAA	0.483000										HNSCC(7;0.00092)			21	86					0	0	1	0	0
ZFHX3	463	broad.mit.edu	37	16	72831514	72831514	+	Silent	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr16:72831514C>T	ENST00000268489.5	-	9	5739	c.5067G>A	c.(5065-5067)ggG>ggA	p.G1689G	ZFHX3_ENST00000397992.5_Silent_p.G775G	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	1689					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				GGGGTGGCATCCCTACACTCT	0.527000													17	104					0	0	1	0	0
PHF3	23469	broad.mit.edu	37	6	64416676	64416676	+	Silent	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr6:64416676C>T	ENST00000262043.3	+	13	3961	c.3621C>T	c.(3619-3621)ttC>ttT	p.F1207F	PHF3_ENST00000393387.1_Silent_p.F1207F			Q92576	PHF3_HUMAN	PHD finger protein 3	1207					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			breast(7)|cervix(2)|endometrium(8)|kidney(7)|large_intestine(18)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(6)	75	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			GATTGAACTTCATCTGGAAAG	0.413000													14	57					0	0	1	0	0
KMT2C	58508	broad.mit.edu	37	7	151845932	151845932	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr7:151845932C>T	ENST00000355193.2	-	53	13469	c.13251G>A	c.(13249-13251)tgG>tgA	p.W4417*	KMT2C_ENST00000262189.6_Nonsense_Mutation_p.W4360*					lysine (K)-specific methyltransferase 2C									p.W4360*(1)|p.W4417*(1)									TATGAATGCTCCACTTCTTCC	0.423000													11	41					0	0	1	0	0
MAPK1	5594	broad.mit.edu	37	22	22127164	22127164	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr22:22127164C>T	ENST00000215832.6	-	7	1152	c.964G>A	c.(964-966)Gag>Aag	p.E322K	MAPK1_ENST00000398822.3_Missense_Mutation_p.E322K|MAPK1_ENST00000544786.1_Missense_Mutation_p.E278K	NM_002745.4	NP_002736.3	P28482	MK01_HUMAN	mitogen-activated protein kinase 1	322					activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle|epidermal growth factor receptor signaling pathway|ERK1 and ERK2 cascade|induction of apoptosis|innate immune response|insulin receptor signaling pathway|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription, DNA-dependent	cytosol|nucleoplasm	ATP binding|DNA binding|MAP kinase activity|phosphatase binding|RNA polymerase II carboxy-terminal domain kinase activity	p.E322K(1)		NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	Colorectal(54;0.105)	all_lung(157;3.89e-05)		READ - Rectum adenocarcinoma(21;0.0689)	Arsenic trioxide(DB01169)	GCTCTTACCTCGTCACTCGGG	0.478000													14	61					0	0	1	0	0
NXPH1	30010	broad.mit.edu	37	7	8791145	8791145	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr7:8791145G>A	ENST00000405863.1	+	3	1473	c.562G>A	c.(562-564)Gat>Aat	p.D188N	NXPH1_ENST00000497400.1_3'UTR|NXPH1_ENST00000602349.1_Missense_Mutation_p.D71N	NM_152745.2	NP_689958.1	P58417	NXPH1_HUMAN	neurexophilin 1	188	V (Cys-rich).					extracellular region		p.D188Y(1)		breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(7)|ovary(1)	17		Ovarian(82;0.0628)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)		TGATGCCAAAGATTCCAAGTC	0.413000													6	32					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414340	20414340	+	Silent	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr9:20414340G>A	ENST00000380338.4	-	5	790	c.504C>T	c.(502-504)agC>agT	p.S168S	MLLT3_ENST00000429426.2_Silent_p.S165S|MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000475957.1_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	168	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S168S(5)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctgctactgctgc	0.537000			T	MLL	ALL								5	73					0	0	1	0	0
LOC148709	148709	broad.mit.edu	37	1	202842517	202842517	+	RNA	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr1:202842517C>T	ENST00000456105.2	+	0	469					NR_002929.2																						ATGTTCCCCTCCATCACTGGG	0.552000													4	12					0	0	1	0	0
PRRG1	5638	broad.mit.edu	37	X	37285149	37285149	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chrX:37285149G>C	ENST00000542554.1	+	4	339	c.67G>C	c.(67-69)Ggg>Cgg	p.G23R	PRRG1_ENST00000543642.1_Missense_Mutation_p.G23R|PRRG1_ENST00000463135.1_Missense_Mutation_p.G23R|PRRG1_ENST00000449135.2_Missense_Mutation_p.G23R|TM4SF2_ENST00000465127.1_Missense_Mutation_p.G23R|PRRG1_ENST00000491253.1_Intron|PRRG1_ENST00000378628.4_Missense_Mutation_p.G23R	NM_001173489.1	NP_001166960.1	O14668	TMG1_HUMAN	proline rich Gla (G-carboxyglutamic acid) 1	23	Gla.					extracellular region|integral to plasma membrane	calcium ion binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	15						AAGAGCTAATGGGTTTTTTGA	0.338000													14	13					0	0	1	0	0
STXBP5L	9515	broad.mit.edu	37	3	120760566	120760566	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr3:120760566G>A	ENST00000273666.6	+	4	578	c.307G>A	c.(307-309)Gat>Aat	p.D103N	STXBP5L_ENST00000472879.1_Missense_Mutation_p.D103N|STXBP5L_ENST00000492541.1_Missense_Mutation_p.D103N|STXBP5L_ENST00000471454.1_Missense_Mutation_p.D103N|STXBP5L_ENST00000497029.1_Missense_Mutation_p.D103N	NM_014980.2	NP_055795.1	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	103					exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(12)|lung(28)|ovary(7)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				GBM - Glioblastoma multiforme(114;0.0694)		ACCTGGTGTTGATTGCTATTG	0.348000													9	54					0	0	1	0	0
WDFY3	23001	broad.mit.edu	37	4	85717800	85717800	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr4:85717800C>T	ENST00000322366.6	-	19	3448	c.3041G>A	c.(3040-3042)gGa>gAa	p.G1014E	WDFY3_ENST00000295888.4_Missense_Mutation_p.G1014E			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	1014						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		TACAGTACTTCCTTCCGCAGA	0.448000													18	82					0	0	1	0	0
CATSPER2P1	440278	broad.mit.edu	37	15	44036355	44036355	+	RNA	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr15:44036355C>T	ENST00000381680.2	-	0	578					NR_002318.2																						TCACGTATTTCAACCATCAGT	0.473000													3	20					0	0	1	0	0
AMFR	267	broad.mit.edu	37	16	56401439	56401439	+	Splice_Site	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr16:56401439G>A	ENST00000290649.5	-	12	1726	c.1515_splice	c.e12-1	p.R506_splice		NM_001144.5	NP_001135.3	Q9UKV5	AMFR2_HUMAN	autocrine motility factor receptor, E3 ubiquitin protein ligase	506					endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|protein oligomerization|protein polyubiquitination	integral to endoplasmic reticulum membrane|integral to membrane of membrane fraction	protein binding|receptor activity|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	17						CTATCTGACCGCTGGAAGAGA	0.493000													5	307					0	0	1	0	0
MYO9A	4649	broad.mit.edu	37	15	72338247	72338247	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr15:72338247C>A	ENST00000356056.5	-	2	1130	c.658G>T	c.(658-660)Gat>Tat	p.D220Y	MYO9A_ENST00000563542.1_5'UTR|MYO9A_ENST00000444904.1_Missense_Mutation_p.D220Y|MYO9A_ENST00000566885.1_Intron|MYO9A_ENST00000564571.1_Missense_Mutation_p.D220Y|MYO9A_ENST00000424560.1_Missense_Mutation_p.D220Y	NM_006901.3	NP_008832.2	B2RTY4	MYO9A_HUMAN	myosin IXA	220	Myosin head-like 1.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(29)|lung(27)|ovary(1)|pancreas(1)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						TAAGCTACATCAGCCACAGCA	0.403000													22	59					7.41877e-09	7.6012e-09	1	1	0
COL6A6	131873	broad.mit.edu	37	3	130300675	130300675	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr3:130300675C>A	ENST00000358511.6	+	8	3849	c.3818C>A	c.(3817-3819)cCa>cAa	p.P1273Q	COL6A6_ENST00000453409.2_Missense_Mutation_p.P1273Q	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	1273	Nonhelical region.|VWFA 7.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						GTTAAAGGACCATCTCTTCTC	0.368000													48	193					1.63038e-21	1.71258e-21	1	1	0
AC005609.1	0	broad.mit.edu	37	5	140242608	140242608	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr5:140242608G>A	ENST00000502505.1	-	1	616	c.368C>T	c.(367-369)gCg>gTg	p.A123V	PCDHA1_ENST00000504120.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA4_ENST00000512229.2_Intron																							CCTGGTTGTCGCAACAGCTGC	0.637000													9	36					0	0	1	0	0
EPHB4	2050	broad.mit.edu	37	7	100421502	100421502	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr7:100421502C>T	ENST00000358173.3	-	3	643	c.175G>A	c.(175-177)Gaa>Aaa	p.E59K	EPHB4_ENST00000360620.3_Missense_Mutation_p.E59K|EPHB4_ENST00000477446.1_5'UTR	NM_004444.4	NP_004435.3	P54760	EPHB4_HUMAN	EPH receptor B4	59					cell proliferation|organ morphogenesis|regulation of angiogenesis	cell surface|integral to plasma membrane	ATP binding|ephrin receptor activity			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(7)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(3)	47	Lung NSC(181;0.041)|all_lung(186;0.0581)					TCACACACTTCGTAGGTGCGC	0.682000													8	23					0	0	1	0	0
STEAP2	261729	broad.mit.edu	37	7	89856755	89856755	+	Silent	SNP	C	C	G			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr7:89856755C>G	ENST00000287908.3	+	3	1356	c.963C>G	c.(961-963)ctC>ctG	p.L321L	STEAP2_ENST00000394622.2_Silent_p.L321L|STEAP2_ENST00000394621.2_Silent_p.L321L|STEAP2_ENST00000394629.2_Silent_p.L321L|STEAP2_ENST00000402625.2_Silent_p.L321L|STEAP2_ENST00000394632.1_Silent_p.L321L|STEAP2_ENST00000394626.1_Silent_p.L321L	NM_001244944.1|NM_152999.3	NP_001231873.1|NP_694544.2	Q8NFT2	STEA2_HUMAN	STEAP family member 2, metalloreductase	321	Ferric oxidoreductase.				electron transport chain|endocytosis|Golgi to plasma membrane transport|ion transport|iron ion homeostasis|regulated secretory pathway|response to hormone stimulus	cytosol|early endosome|endosome membrane|integral to Golgi membrane|plasma membrane|trans-Golgi network transport vesicle|vesicular fraction	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity|transporter activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|prostate(1)|skin(1)	15	all_hematologic(106;0.112)					CCTACAGCCTCTGCTTACCGA	0.398000													14	38					0	0	1	0	0
HOXA13	3209	broad.mit.edu	37	7	27237897	27237897	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr7:27237897C>T	ENST00000222753.4	-	2	1115	c.1087G>A	c.(1087-1089)Gag>Aag	p.E363K		NM_000522.4	NP_000513.2	P31271	HXA13_HUMAN	homeobox A13	363					skeletal system development	nucleus	sequence-specific DNA binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	6						ACCTGCCGCTCAGAGAGATTC	0.413000			T	NUP98	AML								62	211					0	0	1	0	0
GPR111	222611	broad.mit.edu	37	6	47649593	47649593	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr6:47649593C>T	ENST00000398742.2	+	5	1143	c.1094C>T	c.(1093-1095)tCa>tTa	p.S365L	GPR111_ENST00000507065.1_Missense_Mutation_p.S365L|GPR111_ENST00000296862.1_Missense_Mutation_p.S433L			Q8IZF7	GP111_HUMAN	G protein-coupled receptor 111	433					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(2)|lung(15)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	29						ACCTCTTTCTCAATTCTTATG	0.438000													14	101					0	0	1	0	0
OR10J1	26476	broad.mit.edu	37	1	159410358	159410358	+	Silent	SNP	C	C	G			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr1:159410358C>G	ENST00000423932.3	+	1	847	c.810C>G	c.(808-810)ctC>ctG	p.L270L	RP11-550P17.5_ENST00000431862.1_RNA	NM_012351.2	NP_036483.2	P30954	O10J1_HUMAN	olfactory receptor, family 10, subfamily J, member 1	270					sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			endometrium(2)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)|stomach(1)	25	all_hematologic(112;0.0429)					TTGCCTACCTCAAGCCCAAGT	0.527000													8	120					0	0	1	0	0
RERGL	79785	broad.mit.edu	37	12	18234143	18234143	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr12:18234143C>G	ENST00000229002.2	-	6	806	c.600G>C	c.(598-600)aaG>aaC	p.K200N	RERGL_ENST00000538724.1_Missense_Mutation_p.K199N	NM_024730.2	NP_079006.1	Q9H628	RERGL_HUMAN	RERG/RAS-like	200	Small GTPase-like.				signal transduction	membrane	GTP binding|GTPase activity			endometrium(1)|large_intestine(5)|lung(8)|prostate(1)|skin(1)|urinary_tract(1)	17						ATTTCCTTCTCTTTCCAAATA	0.338000													13	21					0	0	1	0	0
NAPG	8774	broad.mit.edu	37	18	10539865	10539865	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr18:10539865G>A	ENST00000322897.6	+	6	434	c.365G>A	c.(364-366)gGa>gAa	p.G122E	NAPG_ENST00000542979.1_Missense_Mutation_p.G40E	NM_003826.2	NP_003817.1	Q99747	SNAG_HUMAN	N-ethylmaleimide-sensitive factor attachment protein, gamma	122					cellular membrane fusion|intra-Golgi vesicle-mediated transport|intracellular protein transport|protein complex assembly|protein stabilization	membrane|membrane fraction|mitochondrion	protein binding			large_intestine(2)|lung(2)	4						GAGCGAGCTGGAAAGTGAGTG	0.443000													12	49					0	0	1	0	0
NKD2	85409	broad.mit.edu	37	5	1037993	1037993	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr5:1037993G>C	ENST00000296849.5	+	10	1090	c.861G>C	c.(859-861)caG>caC	p.Q287H	NKD2_ENST00000274150.4_3'UTR|NKD2_ENST00000382730.2_Intron	NM_033120.2	NP_149111.1	Q969F2	NKD2_HUMAN	naked cuticle homolog 2 (Drosophila)	287					exocytosis|Wnt receptor signaling pathway	cytoplasmic membrane-bounded vesicle|plasma membrane	calcium ion binding|ubiquitin protein ligase binding			breast(1)|central_nervous_system(3)|large_intestine(1)|lung(8)|pancreas(1)	14	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;3.28e-09)		Epithelial(17;0.00093)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00417)|Lung(60;0.165)			CCCGCTCCCAGGAGCCAGATA	0.687000													5	22					0	0	1	0	0
GPR17	2840	broad.mit.edu	37	2	128408991	128408991	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr2:128408991C>T	ENST00000544369.1	+	4	1377	c.766C>T	c.(766-768)Cgc>Tgc	p.R256C	LIMS2_ENST00000355119.4_Intron|GPR17_ENST00000486700.1_3'UTR|LIMS2_ENST00000324938.5_Intron|GPR17_ENST00000272644.3_Missense_Mutation_p.R256C|LIMS2_ENST00000410011.1_Intron|LIMS2_ENST00000545738.2_Intron|GPR17_ENST00000393018.3_Missense_Mutation_p.R256C|LIMS2_ENST00000409808.2_Intron|LIMS2_ENST00000409455.1_Intron	NM_001161415.1	NP_001154887.1	Q13304	GPR17_HUMAN	G protein-coupled receptor 17	256						integral to plasma membrane	chemokine receptor activity|purinergic nucleotide receptor activity, G-protein coupled			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(11)|prostate(2)|urinary_tract(1)	19	Colorectal(110;0.1)	Ovarian(717;0.15)		BRCA - Breast invasive adenocarcinoma(221;0.0677)		TGTGGAGAAGCGCCTCAAGAC	0.622000													4	102					0	0	1	0	0
HHAT	55733	broad.mit.edu	37	1	210796934	210796934	+	Missense_Mutation	SNP	C	C	T	rs113371678		TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr1:210796934C>T	ENST00000367010.1	+	11	1537	c.1310C>T	c.(1309-1311)tCg>tTg	p.S437L	HHAT_ENST00000391905.3_Missense_Mutation_p.S437L|HHAT_ENST00000541565.1_Missense_Mutation_p.S300L|HHAT_ENST00000261458.3_Missense_Mutation_p.S437L|HHAT_ENST00000537898.1_Missense_Mutation_p.S372L|HHAT_ENST00000308852.6_Missense_Mutation_p.S392L|HHAT_ENST00000545781.1_Missense_Mutation_p.S374L|HHAT_ENST00000545154.1_Missense_Mutation_p.S438L|HHAT_ENST00000367009.1_Missense_Mutation_p.S127L|HHAT_ENST00000413764.2_Missense_Mutation_p.S437L	NM_001170580.1	NP_001164051.1	Q5VTY9	HHAT_HUMAN	hedgehog acyltransferase	437					multicellular organismal development	endoplasmic reticulum membrane|integral to membrane	GTP binding			breast(3)|central_nervous_system(1)|kidney(1)|large_intestine(6)|lung(8)|ovary(2)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)	27				OV - Ovarian serous cystadenocarcinoma(81;0.0136)|all cancers(67;0.161)|KIRC - Kidney renal clear cell carcinoma(1967;0.215)		TGTTCCACCTCGATGCTGATC	0.498000													71	293					0	0	1	0	0
SPINT2	10653	broad.mit.edu	37	19	38782595	38782595	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr19:38782595G>T	ENST00000301244.7	+	7	1143	c.708G>T	c.(706-708)tgG>tgT	p.W236C	SPINT2_ENST00000454580.3_Missense_Mutation_p.W179C|CTB-102L5.4_ENST00000591889.1_Intron|SPINT2_ENST00000587090.1_Missense_Mutation_p.W186C	NM_021102.3	NP_066925.1	O43291	SPIT2_HUMAN	serine peptidase inhibitor, Kunitz type, 2	236					cellular component movement	cytoplasm|extracellular region|integral to membrane|soluble fraction	serine-type endopeptidase inhibitor activity			large_intestine(2)|lung(1)|ovary(1)	4	all_cancers(60;6.83e-07)		Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			GCACCGTCTGGAGCTCCGGAG	0.602000													10	27					3.07112e-06	3.13379e-06	1	1	0
NBPF1	55672	broad.mit.edu	37	1	16902903	16902903	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr1:16902903C>G	ENST00000430580.2	-	19	2865	c.1978G>C	c.(1978-1980)Gat>Cat	p.D660H	NBPF1_ENST00000432949.1_Missense_Mutation_p.D118H|NBPF1_ENST00000287968.8_Missense_Mutation_p.D25H	NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1	660						cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		CAGGAGGCATCTCTCCCTTCC	0.532000													11	398					0	0	1	0	0
PCDHA1	56147	broad.mit.edu	37	5	140167659	140167659	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr5:140167659G>A	ENST00000504120.2	+	1	1784	c.1784G>A	c.(1783-1785)cGc>cAc	p.R595H	PCDHA1_ENST00000394633.3_Intron|PCDHA1_ENST00000378133.3_Missense_Mutation_p.R595H	NM_018900.2	NP_061723.1														breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(34)|prostate(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(3)	70			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGAAGGTGCGCGCAGTGGAC	0.692000													33	140					0	0	1	0	0
HTR3C	170572	broad.mit.edu	37	3	183778026	183778026	+	Silent	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr3:183778026G>A	ENST00000318351.1	+	9	1264	c.1230G>A	c.(1228-1230)caG>caA	p.Q410Q		NM_130770.2	NP_570126.2	Q8WXA8	5HT3C_HUMAN	5-hydroxytryptamine (serotonin) receptor 3C, ionotropic	410						integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(2)	32	all_cancers(143;2.33e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			CAAAGACCCAGCTAATGGAGC	0.597000													39	121					0	0	1	0	0
TUBGCP6	85378	broad.mit.edu	37	22	50662572	50662572	+	Silent	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr22:50662572C>T	ENST00000439308.2	-	13	2760	c.2268G>A	c.(2266-2268)gcG>gcA	p.A756A	TUBGCP6_ENST00000491449.1_5'UTR|TUBGCP6_ENST00000248846.5_Silent_p.A756A	NM_020461.3	NP_065194.2	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	756					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			breast(4)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(13)|ovary(3)|prostate(2)|skin(2)	45		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		TGCCCTACCTCGCCTTCCTCT	0.577000													9	44					0	0	1	0	0
TRIM36	55521	broad.mit.edu	37	5	114499269	114499269	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr5:114499269G>A	ENST00000513154.1	-	2	534	c.208C>T	c.(208-210)Cga>Tga	p.R70*	TRIM36_ENST00000282369.3_Nonsense_Mutation_p.R82*|TRIM36_ENST00000515104.1_5'UTR|TRIM36_ENST00000514154.1_Intron			Q9NQ86	TRI36_HUMAN	tripartite motif containing 36	82						acrosomal vesicle|cytoskeleton	ligase activity|zinc ion binding			breast(3)|endometrium(1)|kidney(2)|large_intestine(4)|lung(15)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	37		all_cancers(142;0.00133)|all_epithelial(76;2.41e-05)|Prostate(80;0.00955)|Ovarian(225;0.0443)|Breast(839;0.195)		OV - Ovarian serous cystadenocarcinoma(64;3.62e-08)|Epithelial(69;7.69e-08)|all cancers(49;9.33e-06)		AGCCGAAGTCGAGGACTGCTT	0.453000													17	72					0	0	1	0	0
DUSP19	142679	broad.mit.edu	37	2	183960311	183960311	+	Silent	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr2:183960311C>T	ENST00000354221.4	+	4	754	c.579C>T	c.(577-579)ttC>ttT	p.F193F	DUSP19_ENST00000469344.1_3'UTR|AC064871.3_ENST00000444562.1_RNA|AC064871.3_ENST00000413954.1_RNA|DUSP19_ENST00000342619.6_Silent_p.F142F	NM_080876.3	NP_543152.1	Q8WTR2	DUS19_HUMAN	dual specificity phosphatase 19	193	Tyrosine-protein phosphatase.				JNK cascade|negative regulation of JNK cascade|negative regulation of JUN kinase activity|positive regulation of JNK cascade|positive regulation of JUN kinase activity	cytoplasm	JUN kinase phosphatase activity|MAP-kinase scaffold activity|mitogen-activated protein kinase kinase kinase binding|protein kinase activator activity|protein kinase inhibitor activity|protein tyrosine phosphatase activity			breast(1)|kidney(2)|large_intestine(3)|lung(6)|ovary(4)|pancreas(1)	17						ATTCTGGCTTCATGGAGCAGC	0.393000													18	85					0	0	1	0	0
LRRN1	57633	broad.mit.edu	37	3	3886722	3886722	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr3:3886722G>A	ENST00000319331.3	+	2	1158	c.397G>A	c.(397-399)Gag>Aag	p.E133K	SUMF1_ENST00000534863.1_Intron	NM_020873.5	NP_065924.3	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1	133						integral to membrane				NS(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)|skin(1)|urinary_tract(2)	26				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		TCAGATTACCGAGATGACTGA	0.428000													8	65					0	0	1	0	0
ZNF43	7594	broad.mit.edu	37	19	21991719	21991719	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr19:21991719C>T	ENST00000594012.1	-	7	1616	c.1102G>A	c.(1102-1104)Gaa>Aaa	p.E368K	ZNF43_ENST00000598381.1_Missense_Mutation_p.E368K|ZNF43_ENST00000595461.1_Missense_Mutation_p.E368K|ZNF43_ENST00000354959.4_Missense_Mutation_p.E374K	NM_001256649.1|NM_001256651.1|NM_001256653.1|NM_001256654.1	NP_001243578.1|NP_001243580.1|NP_001243582.1|NP_001243583.1	P17038	ZNF43_HUMAN	zinc finger protein 43	374					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(16)|ovary(2)|prostate(3)|stomach(3)|upper_aerodigestive_tract(2)	51		Renal(1328;0.000219)|Hepatocellular(1079;0.121)		GBM - Glioblastoma multiforme(1328;5.97e-05)|STAD - Stomach adenocarcinoma(1328;0.0127)		TCACCACATTCTGTACATTTA	0.368000													13	67					0	0	1	0	0
NADK	65220	broad.mit.edu	37	1	1686840	1686840	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr1:1686840G>A	ENST00000344463.4	-	9	1317	c.1096C>T	c.(1096-1098)Cag>Tag	p.Q366*	NADK_ENST00000341991.3_Nonsense_Mutation_p.Q221*|NADK_ENST00000378625.1_Nonsense_Mutation_p.Q366*|NADK_ENST00000341426.5_Nonsense_Mutation_p.Q221*|NADK_ENST00000342348.5_Nonsense_Mutation_p.Q189*			O95544	NADK_HUMAN	NAD kinase	221					ATP metabolic process|NAD metabolic process|water-soluble vitamin metabolic process	cytosol	ATP binding|metal ion binding|NAD+ kinase activity|protein binding			NS(1)|autonomic_ganglia(1)|endometrium(4)|large_intestine(2)|lung(4)|ovary(1)|prostate(2)|stomach(1)|urinary_tract(1)	17	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.61e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;8.75e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.33e-23)|GBM - Glioblastoma multiforme(42;1.35e-07)|Colorectal(212;0.000203)|COAD - Colon adenocarcinoma(227;0.000225)|Kidney(185;0.00265)|STAD - Stomach adenocarcinoma(132;0.00655)|BRCA - Breast invasive adenocarcinoma(365;0.00855)|KIRC - Kidney renal clear cell carcinoma(229;0.0382)|Lung(427;0.207)		ACTTGGGACTGAAAGTTCTCA	0.592000													60	197					0	0	1	0	0
FERD3L	222894	broad.mit.edu	37	7	19184632	19184632	+	Silent	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr7:19184632G>A	ENST00000275461.3	-	1	412	c.354C>T	c.(352-354)aaC>aaT	p.N118N	AC003986.5_ENST00000452700.1_RNA	NM_152898.2	NP_690862.1	Q96RJ6	FER3L_HUMAN	Fer3-like bHLH transcription factor	118	Helix-loop-helix motif.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|endometrium(4)|large_intestine(8)|lung(16)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	35						CAAAGGCCTCGTTGAGGTTGA	0.592000													14	34					0	0	1	0	0
CDH4	1002	broad.mit.edu	37	20	60503417	60503417	+	Silent	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr20:60503417C>T	ENST00000360469.5	+	12	2029	c.1941C>T	c.(1939-1941)taC>taT	p.Y647Y	CDH4_ENST00000543233.1_Silent_p.Y573Y	NM_001794.3	NP_001785.2	P55283	CADH4_HUMAN	cadherin 4, type 1, R-cadherin (retinal)	647	Cadherin 5.				adherens junction organization|cell junction assembly		calcium ion binding	p.Y647Y(1)		NS(2)|breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(2)|lung(25)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			TCGGCCCCTACGTCTTCGAGC	0.652000													29	148					0	0	1	0	0
PLEKHB2	55041	broad.mit.edu	37	2	131904248	131904248	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr2:131904248C>T	ENST00000403716.1	+	8	1131	c.571C>T	c.(571-573)Cga>Tga	p.R191*	PLEKHB2_ENST00000538982.1_Nonsense_Mutation_p.R143*|PLEKHB2_ENST00000409158.1_Nonsense_Mutation_p.R199*|PLEKHB2_ENST00000303908.3_Intron|PLEKHB2_ENST00000234115.6_Nonsense_Mutation_p.R190*|PLEKHB2_ENST00000438882.2_Silent_p.F154F|PLEKHB2_ENST00000439822.2_Silent_p.F146F|PLEKHB2_ENST00000409612.1_Nonsense_Mutation_p.R191*|PLEKHB2_ENST00000409279.1_Nonsense_Mutation_p.R191*|PLEKHB2_ENST00000404460.1_Intron	NM_001100623.1|NM_001267062.1|NM_001267063.1|NM_001267064.1|NM_001267065.1|NM_001267066.1|NM_017958.2	NP_001094093.1|NP_001253991.1|NP_001253992.1|NP_001253993.1|NP_001253994.1|NP_001253995.1|NP_060428.2	Q96CS7	PKHB2_HUMAN	pleckstrin homology domain containing, family B (evectins) member 2	191						membrane	protein binding			large_intestine(1)|lung(3)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.0828)		AGTCATCATTCGAGAGCGCTA	0.507000													61	210					0	0	1	0	0
ARID1A	8289	broad.mit.edu	37	1	27058005	27058005	+	Silent	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr1:27058005G>A	ENST00000324856.7	+	3	2084	c.1713G>A	c.(1711-1713)tcG>tcA	p.S571S	ARID1A_ENST00000457599.2_Silent_p.S571S|ARID1A_ENST00000374152.2_Silent_p.S188S	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	571					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding		ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CAGCACCCTCGACGCTCTCCC	0.622000			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								5	377					0	0	1	0	0
KIAA0586	9786	broad.mit.edu	37	14	58932576	58932576	+	Missense_Mutation	SNP	A	A	C			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr14:58932576A>C	ENST00000423743.3	+	16	2209	c.1951A>C	c.(1951-1953)Aca>Cca	p.T651P	KIAA0586_ENST00000556134.1_Missense_Mutation_p.T680P|KIAA0586_ENST00000538571.2_3'UTR|KIAA0586_ENST00000354386.6_Missense_Mutation_p.T748P|KIAA0586_ENST00000261244.5_Missense_Mutation_p.T619P	NM_001244191.1|NM_001244192.1	NP_001231120.1|NP_001231121.1	E9PGW8	E9PGW8_HUMAN	KIAA0586	619										endometrium(4)|kidney(6)|large_intestine(8)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						GTCAATAAGAACACAGACTGA	0.333000													14	52					0	0	1	0	0
LOC100294341	100294341	broad.mit.edu	37	17	43587576	43587576	+	RNA	SNP	A	A	G	rs145439557	by1000genomes	TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr17:43587576A>G	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							tctgaaaagaaaagaaaaaaa	0.428000													5	89					0	0	1	0	0
CSNK2A1	1457	broad.mit.edu	37	20	470429	470429	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr20:470429C>T	ENST00000217244.3	-	10	1093	c.718G>A	c.(718-720)Gat>Aat	p.D240N	CSNK2A1_ENST00000400217.1_Missense_Mutation_p.D104N|CSNK2A1_ENST00000400227.3_Missense_Mutation_p.D240N|CSNK2A1_ENST00000349736.5_Missense_Mutation_p.D240N|CSNK2A1_ENST00000460062.1_5'UTR	NM_177559.2	NP_808227.1	P68400	CSK21_HUMAN	casein kinase 2, alpha 1 polypeptide	240	Protein kinase.				axon guidance|Wnt receptor signaling pathway	cytosol|NuRD complex|plasma membrane|Sin3 complex	ATP binding|protein N-terminus binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)|urinary_tract(1)	17		Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.0969)			ATTACCTGATCATAATTGTCA	0.398000													5	38					0	0	1	0	0
FANCD2	2177	broad.mit.edu	37	3	10085540	10085540	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr3:10085540G>A	ENST00000287647.3	+	14	1219	c.1126G>A	c.(1126-1128)Gaa>Aaa	p.E376K	FANCD2_ENST00000419585.1_Missense_Mutation_p.E376K|FANCD2_ENST00000383807.1_Missense_Mutation_p.E376K|FANCD2_ENST00000383806.1_Missense_Mutation_p.E376K	NM_033084.3	NP_149075.2	Q9BXW9	FACD2_HUMAN	Fanconi anemia, complementation group D2	376					DNA repair|response to gamma radiation	nucleoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	51				OV - Ovarian serous cystadenocarcinoma(96;0.148)		CTCAGTATCTGAACACAAGGT	0.398000			"""D, Mis, N, F"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				7	19					0	0	1	0	0
SERPINA6	866	broad.mit.edu	37	14	94776138	94776138	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr14:94776138C>T	ENST00000341584.3	-	3	965	c.819G>A	c.(817-819)atG>atA	p.M273I		NM_001756.3	NP_001747.2	P08185	CBG_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6	273					regulation of proteolysis|transport	extracellular space	serine-type endopeptidase inhibitor activity|steroid binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(11)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	26		all_cancers(154;0.0482)|all_epithelial(191;0.166)		COAD - Colon adenocarcinoma(157;0.211)	Alclometasone(DB00240)|Beclomethasone(DB00394)|Ciclesonide(DB01410)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Halobetasol Propionate(DB00596)|Medrysone(DB00253)|Mitotane(DB00648)|Paramethasone(DB01384)|Prednisolone(DB00860)|Rimexolone(DB00896)|Triamcinolone(DB00620)	TGACTGTGTTCATCTTCCCCT	0.542000													27	87					0	0	1	0	0
NUDT16	131870	broad.mit.edu	37	3	131100765	131100765	+	Silent	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr3:131100765C>T	ENST00000359850.3	+	1	157	c.18C>T	c.(16-18)atC>atT	p.I6I	NUDT16_ENST00000521288.1_Silent_p.I39I|NUDT16_ENST00000537561.1_Intron|NUDT16_ENST00000502852.1_Silent_p.I39I	NM_152395.2	NP_689608.2	Q96DE0	NUD16_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 16	39						nucleolus|nucleoplasm	hydrolase activity|metal ion binding|RNA binding			large_intestine(1)|lung(6)	7						TCGGCCGCATCCCGCTGCGCT	0.721000													6	38					0	0	1	0	0
TBC1D24	57465	broad.mit.edu	37	16	2550908	2550908	+	Silent	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr16:2550908C>T	ENST00000567020.1	+	7	1751	c.1611C>T	c.(1609-1611)ttC>ttT	p.F537F	TBC1D24_ENST00000293970.5_Silent_p.F543F|TBC1D24_ENST00000434757.2_Silent_p.F543F|RP11-20I23.1_ENST00000564543.1_Intron	NM_020705.2	NP_065756.1	Q9ULP9	TBC24_HUMAN	TBC1 domain family, member 24	543	TLD.				neuron projection development	cytoplasm	protein binding|Rab GTPase activator activity			endometrium(2)|kidney(4)|large_intestine(3)|lung(4)	13						CCGAGAACTTCCTCATTGCTG	0.672000											OREG0023552	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	44					0	0	1	0	0
FANCD2	2177	broad.mit.edu	37	3	10085242	10085242	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr3:10085242G>A	ENST00000287647.3	+	13	1157	c.1064G>A	c.(1063-1065)aGa>aAa	p.R355K	FANCD2_ENST00000419585.1_Missense_Mutation_p.R355K|FANCD2_ENST00000383807.1_Missense_Mutation_p.R355K|FANCD2_ENST00000383806.1_Missense_Mutation_p.R355K	NM_033084.3	NP_149075.2	Q9BXW9	FACD2_HUMAN	Fanconi anemia, complementation group D2	355	Interaction with BRCA2.				DNA repair|response to gamma radiation	nucleoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	51				OV - Ovarian serous cystadenocarcinoma(96;0.148)		TCAGCTATTAGATATGAGAAA	0.368000			"""D, Mis, N, F"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				10	50					0	0	1	0	0
PCSK5	5125	broad.mit.edu	37	9	78936474	78936474	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr9:78936474G>A	ENST00000545128.1	+	30	4478	c.3940G>A	c.(3940-3942)Gag>Aag	p.E1314K		NM_001190482.1	NP_001177411.1	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	726					anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|liver(2)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55						AAACTGCCCCGAGAGGCACGT	0.547000													8	75					0	0	1	0	0
FAM187A	100528020	broad.mit.edu	37	17	42979942	42979942	+	Translation_Start_Site	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr17:42979942G>A	ENST00000331733.4	+	0	581				CCDC103_ENST00000410006.2_Silent_p.A162A|FAM187A_ENST00000412523.2_Intron|CCDC103_ENST00000417826.2_Silent_p.A162A	NM_001258399.1|NM_213607.2	NP_001245328.1|NP_998772.1			family with sequence similarity 187, member A																		ACCGGGCAGCGGTGCTGGGGA	0.632000													7	114					0	0	1	0	0
KCNC3	3748	broad.mit.edu	37	19	50831719	50831719	+	Silent	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr19:50831719G>A	ENST00000376959.2	-	1	784	c.621C>T	c.(619-621)ccC>ccT	p.P207P	KCNC3_ENST00000477616.1_Silent_p.P207P|KCNC3_ENST00000474951.1_Intron|KCNC3_ENST00000391818.2_Intron			Q14003	KCNC3_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 3	207					cell death	voltage-gated potassium channel complex	voltage-gated potassium channel activity	p.A208fs*116(1)		endometrium(2)|large_intestine(4)|lung(5)|pancreas(1)|skin(1)	13		all_neural(266;0.057)|Ovarian(192;0.208)		OV - Ovarian serous cystadenocarcinoma(262;0.00283)|GBM - Glioblastoma multiforme(134;0.0181)		CGGCGCCCGCGGGGTCGGGCG	0.776000													3	25					0	0	1	0	0
ORAI2	80228	broad.mit.edu	37	7	102087373	102087373	+	Silent	SNP	C	C	G			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr7:102087373C>G	ENST00000356387.2	+	4	874	c.639C>G	c.(637-639)gtC>gtG	p.V213V	ORAI2_ENST00000403646.3_Silent_p.V213V|ORAI2_ENST00000478730.1_Silent_p.V213V|ORAI2_ENST00000488996.1_3'UTR|ORAI2_ENST00000473939.1_Silent_p.V213V	NM_001126340.1|NM_001271818.1|NM_001271819.1|NM_032831.3	NP_001119812.1|NP_001258747.1|NP_001258748.1|NP_116220.1	Q96SN7	ORAI2_HUMAN	ORAI calcium release-activated calcium modulator 2	213						integral to membrane	protein binding			autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(1)|lung(4)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	15						TCTTCGTGGTCTTCACCATCC	0.662000													4	38					0	0	1	0	0
GPX1	2876	broad.mit.edu	37	3	49395178	49395178	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr3:49395178C>G	ENST00000419783.1	-	2	576	c.255G>C	c.(253-255)gaG>gaC	p.E85D	GPX1_ENST00000419349.1_3'UTR|GPX1_ENST00000496791.1_5'UTR	NM_000581.2	NP_000572.2	P07203	GPX1_HUMAN	glutathione peroxidase 1	85					anti-apoptosis|cell redox homeostasis|glutathione metabolic process|heart contraction|hydrogen peroxide catabolic process|negative regulation of caspase activity|purine base metabolic process|purine nucleotide catabolic process|regulation of gene expression, epigenetic|regulation of mammary gland epithelial cell proliferation|regulation of proteasomal protein catabolic process|release of cytochrome c from mitochondria|response to selenium ion|UV protection	cytosol|mitochondrion	endopeptidase inhibitor activity|glutathione peroxidase activity|SH3 domain binding			breast(1)|large_intestine(2)|lung(1)	4				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	Glutathione(DB00143)	TCTTGGCGTTCTCCTACAGGA	0.517000													20	80					0	0	1	0	0
TBL1Y	90665	broad.mit.edu	37	Y	6939823	6939823	+	Silent	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chrY:6939823G>A	ENST00000383032.1	+	12	1493	c.846G>A	c.(844-846)ctG>ctA	p.L282L	TBL1Y_ENST00000346432.3_Silent_p.L282L|TBL1Y_ENST00000355162.2_Silent_p.L282L	NM_033284.1	NP_150600.1	Q9BQ87	TBL1Y_HUMAN	transducin (beta)-like 1, Y-linked	282					transcription, DNA-dependent					kidney(1)|large_intestine(4)|lung(2)|skin(1)	8						TCTTCGCTCTGAAATGGAACA	0.388000													7	16					0	0	1	0	0
C14orf182	283551	broad.mit.edu	37	14	50472359	50472359	+	Silent	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr14:50472359G>A	ENST00000399206.1	-	1	1879	c.159C>T	c.(157-159)ttC>ttT	p.F53F	C14orf182_ENST00000529902.1_5'UTR	NM_001012706.1	NP_001012724.1	A1A4T8	CN182_HUMAN	chromosome 14 open reading frame 182	53										large_intestine(2)|urinary_tract(1)	3						GCAAGAAGACGAAATGTCTGT	0.532000													37	174					0	0	1	0	0
NDEL1	81565	broad.mit.edu	37	17	8354194	8354194	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr17:8354194C>G	ENST00000334527.7	+	6	820	c.623C>G	c.(622-624)tCc>tGc	p.S208C	NDEL1_ENST00000402554.3_Missense_Mutation_p.S208C|NDEL1_ENST00000380025.4_Missense_Mutation_p.S208C|NDEL1_ENST00000585098.1_Intron|NDEL1_ENST00000299734.7_Missense_Mutation_p.S208C	NM_030808.4	NP_110435.1	Q9GZM8	NDEL1_HUMAN	nudE neurodevelopment protein 1-like 1	208	Interaction with CENPF.|Interaction with KATNA1 (By similarity).|Interaction with NEFL (By similarity).|Interaction with YWHAE (By similarity).				chromosome segregation|mitotic prometaphase	condensed chromosome kinetochore|cytosol|microtubule|spindle				large_intestine(6)|lung(4)|skin(3)	13						AAGATGGACTCCGCCGTCCAA	0.453000													10	32					0	0	1	0	0
TRIB1	10221	broad.mit.edu	37	8	126445713	126445713	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr8:126445713G>A	ENST00000311922.3	+	2	1097	c.515G>A	c.(514-516)cGa>cAa	p.R172Q	TRIB1_ENST00000520847.1_Missense_Mutation_p.R6Q|TRIB1_ENST00000521778.1_3'UTR	NM_025195.2	NP_079471.1	Q96RU8	TRIB1_HUMAN	tribbles pseudokinase 1	172	Protein kinase.				JNK cascade|negative regulation of lipopolysaccharide-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell proliferation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of MAP kinase activity|response to lipopolysaccharide	cytoplasm|nucleus	ATP binding|mitogen-activated protein kinase kinase binding|protein kinase activity|protein kinase inhibitor activity|transcription factor binding|ubiquitin protein ligase binding|ubiquitin-protein ligase regulator activity			NS(1)|large_intestine(2)|lung(2)|prostate(2)|urinary_tract(1)	8	all_hematologic(1;4.97e-05)|Ovarian(258;0.00167)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)			TCCTATGTGCGAAGCCGGAAG	0.577000													5	191					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79026961	79026961	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr5:79026961C>G	ENST00000446378.2	+	2	2404	c.2373C>G	c.(2371-2373)ttC>ttG	p.F791L		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	791						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		GTGAACGTTTCACACCGGATT	0.453000													24	85					0	0	1	0	0
SPAG5	10615	broad.mit.edu	37	17	26912913	26912913	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr17:26912913C>T	ENST00000321765.5	-	7	2041	c.1709G>A	c.(1708-1710)aGa>aAa	p.R570K		NM_006461.3	NP_006452.3	Q96R06	SPAG5_HUMAN	sperm associated antigen 5	570					cell division|mitosis|phosphatidylinositol-mediated signaling|spindle organization	condensed chromosome kinetochore|cytoplasm|spindle pole	protein binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(17)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	43	Lung NSC(42;0.00431)					CATTTCCTCTCTGTGCCTTGC	0.502000													50	215					0	0	1	0	0
CADPS	8618	broad.mit.edu	37	3	62860622	62860622	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr3:62860622G>A	ENST00000383710.4	-	1	432	c.83C>T	c.(82-84)cCg>cTg	p.P28L	CADPS_ENST00000357948.3_Missense_Mutation_p.P28L|CADPS_ENST00000283269.9_Missense_Mutation_p.P28L|CADPS_ENST00000490353.2_Missense_Mutation_p.P28L	NM_003716.3	NP_003707.2	Q9ULU8	CAPS1_HUMAN	Ca++-dependent secretion activator	28					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			breast(3)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(24)|lung(38)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(2)	92		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		CGCGCCGGACGGGGCCGAGCC	0.746000													3	13					0	0	1	0	0
ZSCAN5B	342933	broad.mit.edu	37	19	56704176	56704176	+	Silent	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr19:56704176C>T	ENST00000586855.2	-	2	559	c.246G>A	c.(244-246)caG>caA	p.Q82Q	ZSCAN5B_ENST00000358992.3_Silent_p.Q82Q			A6NJL1	ZSA5B_HUMAN	zinc finger and SCAN domain containing 5B	82	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(5)|large_intestine(3)|lung(23)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37						TGTCCAGGATCTGCTCTTTGG	0.577000													7	26					0	0	1	0	0
GPR55	9290	broad.mit.edu	37	2	231774925	231774925	+	Silent	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr2:231774925C>T	ENST00000392040.1	-	2	945	c.753G>A	c.(751-753)ctG>ctA	p.L251L	GPR55_ENST00000392039.2_Silent_p.L251L	NM_005683.3	NP_005674.2	Q9Y2T6	GPR55_HUMAN	G protein-coupled receptor 55	251					activation of phospholipase C activity|bone resorption|negative regulation of osteoclast differentiation|positive regulation of ERK1 and ERK2 cascade|positive regulation of Rho protein signal transduction	integral to plasma membrane	cannabinoid receptor activity			endometrium(1)|large_intestine(1)|lung(14)|ovary(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		Renal(207;0.0112)|all_lung(227;0.0741)|all_hematologic(139;0.0748)|Acute lymphoblastic leukemia(138;0.167)|Lung NSC(271;0.204)		Epithelial(121;1.04e-11)|all cancers(144;4.22e-09)|LUSC - Lung squamous cell carcinoma(224;0.0119)|Lung(119;0.0145)		TGTTTCTCACCAGGAACTGCA	0.542000													20	97					0	0	1	0	0
TLE1	7088	broad.mit.edu	37	9	84226773	84226773	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr9:84226773C>T	ENST00000376499.3	-	13	2229	c.1165G>A	c.(1165-1167)Gct>Act	p.A389T	TLE1_ENST00000376484.1_Missense_Mutation_p.A64T|TLE1_ENST00000376472.1_Missense_Mutation_p.A64T|TLE1_ENST00000464999.1_5'UTR	NM_005077.3	NP_005068.2	Q04724	TLE1_HUMAN	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	389	Pro/Ser-rich.				negative regulation of Wnt receptor signaling pathway|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway		transcription factor binding			NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	29						GCGTAGGCAGCGCCTGGGCTG	0.687000													15	64					0	0	1	0	0
IPO5	3843	broad.mit.edu	37	13	98655279	98655279	+	Silent	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr13:98655279G>A	ENST00000261574.5	+	16	1719	c.1539G>A	c.(1537-1539)ctG>ctA	p.L513L	IPO5_ENST00000493492.2_3'UTR|IPO5_ENST00000539640.1_Silent_p.L370L|IPO5_ENST00000490680.1_Silent_p.L495L	NM_002271.4	NP_002262.3	O00410	IPO5_HUMAN	importin 5	495					interspecies interaction between organisms|NLS-bearing substrate import into nucleus|ribosomal protein import into nucleus	cytoplasm|nuclear pore|nucleolus	GTPase inhibitor activity|protein transporter activity|Ran GTPase binding			breast(2)|endometrium(2)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	27						TTATGGTACTGAAGCTTCAAG	0.398000													21	180					0	0	1	0	0
PCSK6	5046	broad.mit.edu	37	15	101872144	101872144	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr15:101872144C>G	ENST00000348070.1	-	15	1947	c.1948G>C	c.(1948-1950)Gag>Cag	p.E650Q	PCSK6_ENST00000561177.1_5'UTR|PCSK6_ENST00000358417.3_Missense_Mutation_p.E650Q	NM_002570.3|NM_138320.1	NP_002561.1|NP_612193.1	P29122	PCSK6_HUMAN	proprotein convertase subtilisin/kexin type 6	651					glycoprotein metabolic process|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|regulation of BMP signaling pathway|secretion by cell	cell surface|endomembrane system|endoplasmic reticulum|extracellular matrix|extracellular space|Golgi lumen|membrane|soluble fraction	eukaryotic cell surface binding|heparin binding|nerve growth factor binding|serine-type endopeptidase activity			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Lung NSC(78;0.00102)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000803)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			GCTGAGAGCTCCAGCATCCGC	0.572000													6	31					0	0	1	0	0
PCSK4	54760	broad.mit.edu	37	19	1489887	1489887	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr19:1489887C>T	ENST00000300954.5	-	2	260	c.199G>A	c.(199-201)Gac>Aac	p.D67N	PCSK4_ENST00000587784.1_Intron	NM_017573.3	NP_060043.2	Q6UW60	PCSK4_HUMAN	proprotein convertase subtilisin/kexin type 4	67					proteolysis	integral to membrane	serine-type endopeptidase activity			cervix(2)|endometrium(2)|kidney(1)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	15		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TACTGCCCGTCAGGGAAGATC	0.667000													3	12					0	0	1	0	0
NIPBL	25836	broad.mit.edu	37	5	37051956	37051956	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr5:37051956G>A	ENST00000282516.8	+	41	7529	c.7030G>A	c.(7030-7032)Gaa>Aaa	p.E2344K	NIPBL_ENST00000448238.2_Missense_Mutation_p.E2344K	NM_015384.4|NM_133433.3	NP_056199.2|NP_597677.2	Q6KC79	NIPBL_HUMAN	Nipped-B homolog (Drosophila)	2344					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			autonomic_ganglia(1)|breast(4)|endometrium(9)|kidney(22)|large_intestine(21)|liver(1)|lung(47)|ovary(7)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	128	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			GCAACTTGTGGAAATAGACAA	0.313000													10	45					0	0	1	0	0
DEFB136	613210	broad.mit.edu	37	8	11832092	11832092	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr8:11832092G>C	ENST00000382209.2	-	1	16	c.17C>G	c.(16-18)tCt>tGt	p.S6C		NM_001033018.2	NP_001028190.2	Q30KP8	DB136_HUMAN	defensin, beta 136	6					defense response to bacterium	extracellular region				endometrium(2)|large_intestine(1)|lung(4)	7			STAD - Stomach adenocarcinoma(15;0.033)	COAD - Colon adenocarcinoma(149;0.163)		GAGTAATGCAGAAAGACAGAG	0.507000													31	134					0	0	1	0	0
RNF216	54476	broad.mit.edu	37	7	5781327	5781327	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr7:5781327C>G	ENST00000389902.3	-	4	588	c.321G>C	c.(319-321)aaG>aaC	p.K107N	RNF216_ENST00000425013.2_Intron			Q9NWF9	RN216_HUMAN	ring finger protein 216	65					apoptosis|interspecies interaction between organisms|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination|regulation of defense response to virus by host|regulation of interferon-beta production	cytoplasm|nucleus	ligase activity|protein binding|zinc ion binding		FBXL18/RNF216(2)	breast(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(11)|ovary(3)|prostate(1)|skin(1)|urinary_tract(4)	33		Ovarian(82;0.07)		UCEC - Uterine corpus endometrioid carcinoma (126;0.135)|OV - Ovarian serous cystadenocarcinoma(56;2.69e-13)		AATAGCTGCTCTTATCTGATT	0.458000													36	145					0	0	1	0	0
HIST2H2AB	317772	broad.mit.edu	37	1	149859298	149859298	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr1:149859298C>G	ENST00000331128.3	-	1	168	c.169G>C	c.(169-171)Gag>Cag	p.E57Q		NM_175065.2	NP_778235.1	Q8IUE6	H2A2B_HUMAN	histone cluster 2, H2ab	57					nucleosome assembly	nucleosome|nucleus	DNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	15	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			GTCAGGTACTCGAGGACCGCC	0.662000													32	109					0	0	1	0	0
PSG4	5672	broad.mit.edu	37	19	43702371	43702371	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr19:43702371C>T	ENST00000405312.3	-	3	724	c.487G>A	c.(487-489)Gag>Aag	p.E163K	PSG4_ENST00000244295.9_Missense_Mutation_p.E163K|PSG4_ENST00000433626.2_Intron	NM_002780.3	NP_002771.2	Q00888	PSG4_HUMAN	pregnancy specific beta-1-glycoprotein 4	163	Ig-like C2-type 1.				defense response|female pregnancy	extracellular region				central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(10)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	24		Prostate(69;0.00682)				ATCACAGCCTCCATGGCCTCC	0.547000													67	263					0	0	1	0	0
MON1A	84315	broad.mit.edu	37	3	49948975	49948975	+	Silent	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr3:49948975G>A	ENST00000417270.1	-	4	1314	c.621C>T	c.(619-621)atC>atT	p.I207I	CTD-2330K9.3_ENST00000419183.1_Intron|MON1A_ENST00000296473.3_Silent_p.I296I|MON1A_ENST00000455683.2_Intron			Q86VX9	MON1A_HUMAN	MON1 secretory trafficking family member A	199							protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(2)|prostate(1)	13				BRCA - Breast invasive adenocarcinoma(193;4.62e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		GGATGGAGCGGATGGCGTTCT	0.597000													18	68					0	0	1	0	0
MON1A	84315	broad.mit.edu	37	3	49949205	49949205	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr3:49949205G>C	ENST00000417270.1	-	4	1084	c.391C>G	c.(391-393)Ccc>Gcc	p.P131A	CTD-2330K9.3_ENST00000419183.1_Intron|MON1A_ENST00000296473.3_Missense_Mutation_p.P220A|MON1A_ENST00000483022.1_5'UTR|MON1A_ENST00000455683.2_Intron			Q86VX9	MON1A_HUMAN	MON1 secretory trafficking family member A	123							protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(2)|prostate(1)	13				BRCA - Breast invasive adenocarcinoma(193;4.62e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		GCCCCTGGGGGTTCCAGCCAA	0.657000													16	72					0	0	1	0	0
BAG2	9532	broad.mit.edu	37	6	57048881	57048881	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr6:57048881C>G	ENST00000370693.5	+	3	901	c.529C>G	c.(529-531)Ctg>Gtg	p.L177V	BAG2_ENST00000545080.1_Missense_Mutation_p.L144V	NM_004282.3	NP_004273.1	O95816	BAG2_HUMAN	BCL2-associated athanogene 2	177	BAG.				apoptosis|protein folding		protein binding			endometrium(1)|large_intestine(1)	2	Lung NSC(77;0.126)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			ATTAGAGACTCTGCTTAGAAA	0.393000													14	50					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453155	140453155	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr7:140453155C>T	ENST00000288602.6	-	15	1840	c.1780G>A	c.(1780-1782)Gat>Aat	p.D594N		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	594	Protein kinase.		D -> G (in NHL).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.D594N(9)|p.D594H(2)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	AGACCAAAATCACCTATTTTT	0.378000		61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				14	57					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20975195	20975195	+	Silent	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr16:20975195C>T	ENST00000261383.3	-	53	10010	c.10011G>A	c.(10009-10011)acG>acA	p.T3337T	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3337					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		CCTCGCTCTTCGTGCTGTGGG	0.478000													37	104					0	0	1	0	0
ADAMTS10	81794	broad.mit.edu	37	19	8657722	8657722	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr19:8657722C>G	ENST00000270328.4	-	12	1778	c.1512G>C	c.(1510-1512)aaG>aaC	p.K504N	ADAMTS10_ENST00000597188.1_Missense_Mutation_p.K504N			Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 10	504	Disintegrin.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(16)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(3)|skin(10)|urinary_tract(1)	53						ACCGGTTGCTCTTGCTCAGAC	0.716000													3	29					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32023946	32023946	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr6:32023946C>T	ENST00000375244.3	-	24	8350	c.8149G>A	c.(8149-8151)Gag>Aag	p.E2717K	TNXB_ENST00000375247.2_Missense_Mutation_p.E2717K			P22105	TENX_HUMAN	tenascin XB	2775	Fibronectin type-III 19.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						GTCTCTTCCTCTGCAGCTGAG	0.612000													10	45					0	0	1	0	0
C3AR1	719	broad.mit.edu	37	12	8212398	8212398	+	Silent	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr12:8212398G>A	ENST00000307637.4	-	2	587	c.384C>T	c.(382-384)atC>atT	p.I128I		NM_004054.2	NP_004045.1	Q16581	C3AR_HUMAN	complement component 3a receptor 1	128					blood circulation|chemotaxis|elevation of cytosolic calcium ion concentration|inflammatory response	integral to plasma membrane	C3a anaphylatoxin receptor activity|complement component C3a receptor activity|phosphatidylinositol phospholipase C activity			breast(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(1)	20				Kidney(36;0.0893)		TCTGACACCAGATTGGCTTGA	0.502000													16	82					0	0	1	0	0
FREM2	341640	broad.mit.edu	37	13	39261962	39261962	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr13:39261962G>A	ENST00000280481.7	+	1	697	c.481G>A	c.(481-483)Gga>Aga	p.G161R		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	161					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		TGACGCGCCCGGAGGGGCAGT	0.667000													5	15					0	0	1	0	0
C16orf3	750	broad.mit.edu	37	16	90095621	90095621	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr16:90095621C>T	ENST00000408886.2	-	1	688	c.130G>A	c.(130-132)Gta>Ata	p.V44I	GAS8_ENST00000540721.1_Intron|GAS8_ENST00000536122.1_Intron|GAS8_ENST00000268699.4_Intron	NM_001214.3	NP_001205.3	O95177	CP003_HUMAN	chromosome 16 open reading frame 3	44										large_intestine(1)|lung(2)|prostate(1)	4		all_cancers(9;9.01e-08)|Hepatocellular(780;0.000325)|Lung NSC(15;0.0104)|all_lung(18;0.0239)		BRCA - Breast invasive adenocarcinoma(80;0.0272)		gggcaggctacggggcaggcC	0.672000													16	44					0	0	1	0	0
OOEP	441161	broad.mit.edu	37	6	74078584	74078584	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr6:74078584C>T	ENST00000370363.1	-	4	700	c.208G>A	c.(208-210)Gag>Aag	p.E70K	OOEP_ENST00000370359.5_Missense_Mutation_p.E125K			A6NGQ2	OOEP_HUMAN	oocyte expressed protein	125	KH; atypical.					cytoplasm				large_intestine(2)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	8						TTCATCTTCTCAGCTGGAAGA	0.483000													7	31					0	0	1	0	0
CATSPER2P1	440278	broad.mit.edu	37	15	44037259	44037259	+	RNA	SNP	C	C	G			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr15:44037259C>G	ENST00000381680.2	-	0	364					NR_002318.2																						CAGCTTGGCTCAAGCCTTGCA	0.463000													27	105					0	0	1	0	0
HLA-B	3106	broad.mit.edu	37	6	31323370	31323370	+	Splice_Site	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr6:31323370C>T	ENST00000412585.2	-	4	648		c.e4-1			NM_005514.6	NP_005505.2			major histocompatibility complex, class I, B											endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(4)|lung(4)|prostate(1)|upper_aerodigestive_tract(2)	27						TTTGGGGGGTCTGATGGGAAG	0.577000									Melanoma, Familial Clustering of;Lichen Sclerosis et Atrophicus, Familial Clustering of				34	145					0	0	1	0	0
ZBTB26	57684	broad.mit.edu	37	9	125682207	125682207	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr9:125682207C>G	ENST00000373656.3	-	2	80	c.7G>C	c.(7-9)Gaa>Caa	p.E3Q	ZBTB26_ENST00000373654.1_Missense_Mutation_p.E3Q	NM_020924.2	NP_065975.1	Q9HCK0	ZBT26_HUMAN	zinc finger and BTB domain containing 26	3					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(4)|prostate(1)	11						TCTGATCTTTCAGACATTTTG	0.303000													4	24					0	0	1	0	0
IGSF10	285313	broad.mit.edu	37	3	151162905	151162905	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr3:151162905C>G	ENST00000282466.3	-	4	4863	c.4864G>C	c.(4864-4866)Gat>Cat	p.D1622H		NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	1622					cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GGTTTCTTATCAAAGTCACTC	0.433000													17	107					0	0	1	0	0
TAS1R2	80834	broad.mit.edu	37	1	19180755	19180755	+	Silent	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr1:19180755G>A	ENST00000375371.3	-	3	1230	c.1209C>T	c.(1207-1209)ctC>ctT	p.L403L	RP13-279N23.2_ENST00000494072.3_3'UTR	NM_152232.2	NP_689418.2	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2	403					detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(10)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(3)|stomach(1)	45		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	TGTCACAGCCGAGGAGGCTGT	0.612000													5	28					0	0	1	0	0
OR9A2	135924	broad.mit.edu	37	7	142724130	142724130	+	Silent	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr7:142724130G>A	ENST00000350513.2	-	1	152	c.90C>T	c.(88-90)ttC>ttT	p.F30F		NM_001001658.1	NP_001001658.1	Q8NGT5	OR9A2_HUMAN	olfactory receptor, family 9, subfamily A, member 2	30					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(3)|endometrium(4)|large_intestine(1)|lung(14)|skin(3)	25	Melanoma(164;0.059)					AGAAGAAAAAGAATATAGCAA	0.433000													21	92					0	0	1	0	0
PCDHA3	56145	broad.mit.edu	37	5	140182393	140182393	+	Silent	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr5:140182393G>A	ENST00000522353.2	+	1	1611	c.1611G>A	c.(1609-1611)gcG>gcA	p.A537A	PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000532566.2_Silent_p.A537A|PCDHA2_ENST00000520672.2_Intron	NM_018906.2	NP_061729.1														NS(1)|breast(1)|endometrium(16)|kidney(3)|large_intestine(19)|lung(36)|ovary(7)|prostate(8)|skin(3)|stomach(1)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGTGAGTGCGCGCGATGCGG	0.667000													58	189					0	0	1	0	0
COG4	25839	broad.mit.edu	37	16	70557288	70557288	+	Silent	SNP	G	G	C			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr16:70557288G>C	ENST00000323786.5	-	1	180	c.159C>G	c.(157-159)ctC>ctG	p.L53L	COG4_ENST00000393612.4_Silent_p.L49L|COG4_ENST00000564653.1_Silent_p.L53L	NM_001195139.1|NM_015386.2	NP_001182068.1|NP_056201.2	Q9H9E3	COG4_HUMAN	component of oligomeric golgi complex 4	49	Interacts with SCFD1.				Golgi organization|Golgi vesicle prefusion complex stabilization|protein transport|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(12)|pancreas(1)|prostate(2)	33		Ovarian(137;0.0694)				CCTCGCCGCAGAGCCGTTCGT	0.617000													18	79					0	0	1	0	0
BSND	7809	broad.mit.edu	37	1	55472860	55472860	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr1:55472860C>G	ENST00000371265.4	+	3	717	c.463C>G	c.(463-465)Cag>Gag	p.Q155E		NM_057176.2	NP_476517.1	Q8WZ55	BSND_HUMAN	Bartter syndrome, infantile, with sensorineural deafness (Barttin)	155						basolateral plasma membrane|cytoplasm|integral to plasma membrane|protein complex				cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	17						TGGCGACGTTCAGGCCTGGAT	0.622000													14	95					0	0	1	0	0
NAA15	80155	broad.mit.edu	37	4	140272760	140272760	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr4:140272760G>T	ENST00000296543.5	+	9	1332	c.1009G>T	c.(1009-1011)Gaa>Taa	p.E337*	NAA15_ENST00000480277.2_3'UTR|NAA15_ENST00000398947.1_Nonsense_Mutation_p.E337*	NM_057175.3	NP_476516.1	Q9BXJ9	NAA15_HUMAN	N(alpha)-acetyltransferase 15, NatA auxiliary subunit	337					angiogenesis|cell differentiation|N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|transcription factor complex	protein binding			NS(1)|endometrium(3)|large_intestine(7)|liver(2)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	29						CAAAGACAAAGAAAAGGTAAA	0.338000													20	68					7.45023e-12	7.76065e-12	1	1	0
FAM129B	64855	broad.mit.edu	37	9	130270248	130270248	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr9:130270248G>A	ENST00000373312.3	-	13	1765	c.1552C>T	c.(1552-1554)Cgg>Tgg	p.R518W	FAM129B_ENST00000373314.3_Missense_Mutation_p.R505W|FAM129B_ENST00000468379.1_Intron	NM_022833.2	NP_073744.2	Q96TA1	NIBL1_HUMAN	family with sequence similarity 129, member B	518							protein binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|liver(1)|lung(7)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	25						TCCTGGAACCGGGGCAGCTCC	0.622000													4	124					0	0	1	0	0
SHMT2	6472	broad.mit.edu	37	12	57626558	57626558	+	Silent	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr12:57626558G>A	ENST00000328923.3	+	7	1241	c.789G>A	c.(787-789)gtG>gtA	p.V263V	SHMT2_ENST00000449049.3_Silent_p.V242V|SHMT2_ENST00000414700.3_Silent_p.V242V|SHMT2_ENST00000557487.1_Silent_p.V253V|SHMT2_ENST00000393827.4_Silent_p.V167V|SHMT2_ENST00000553474.1_Silent_p.V242V	NM_001166356.1|NM_005412.5	NP_001159828.1|NP_005403.2	P34897	GLYM_HUMAN	serine hydroxymethyltransferase 2 (mitochondrial)	263						microtubule cytoskeleton|mitochondrial nucleoid	glycine hydroxymethyltransferase activity|methyltransferase activity			breast(1)|central_nervous_system(1)|large_intestine(4)|liver(2)|lung(3)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	15					Glycine(DB00145)|Pyridoxal Phosphate(DB00114)|Tetrahydrofolic acid(DB00116)	CTGCCAAGGTGATTCCCTCGC	0.602000													17	54					0	0	1	0	0
USP34	9736	broad.mit.edu	37	2	61431476	61431476	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr2:61431476T>C	ENST00000398571.2	-	74	9375	c.9299A>G	c.(9298-9300)aAg>aGg	p.K3100R		NM_014709.3	NP_055524.3	Q70CQ2	UBP34_HUMAN	ubiquitin specific peptidase 34	3100					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			autonomic_ganglia(1)|breast(14)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(52)|ovary(8)|prostate(10)|skin(6)|urinary_tract(2)	138			Epithelial(17;0.229)			TCCTATTAGCTTGATATTTTC	0.413000													12	69					0	0	1	0	0
SMO	6608	broad.mit.edu	37	7	128851608	128851608	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr7:128851608C>A	ENST00000249373.3	+	11	2213	c.1933C>A	c.(1933-1935)Cca>Aca	p.P645T	RP11-286H14.8_ENST00000466717.1_RNA	NM_005631.4	NP_005622.1	Q99835	SMO_HUMAN	smoothened, frizzled family receptor	645					adenohypophysis development|axon extension involved in axon guidance|canonical Wnt receptor signaling pathway|cardioblast differentiation|central nervous system neuron differentiation|cerebellar cortex morphogenesis|ciliary receptor clustering involved in smoothened signaling pathway|determination of left/right symmetry|dorsal/ventral neural tube patterning|embryonic camera-type eye development|embryonic digestive tract morphogenesis|embryonic neurocranium morphogenesis|embryonic viscerocranium morphogenesis|exocrine pancreas development|facial nerve development|floor plate formation|gonad development|heart morphogenesis|muscle cell fate commitment|negative regulation of apoptosis|neural crest cell migration|neuron fate commitment|neuron projection regeneration|odontogenesis of dentine-containing tooth|osteoblast differentiation|otolith morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of neuroblast proliferation|positive regulation of smoothened signaling pathway|semicircular canal morphogenesis|smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation|smoothened signaling pathway involved in ventral spinal cord patterning|spermatogenesis|vasculogenesis	cilium|cytoplasm|integral to membrane|neuronal cell body|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			biliary_tract(1)|central_nervous_system(5)|endometrium(1)|kidney(4)|large_intestine(14)|liver(1)|lung(11)|pancreas(2)|prostate(1)|skin(20)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						TGTGGCAACTCCAGGTATGAG	0.597000			Mis		skin basal cell								12	54					7.03913e-09	7.2419e-09	1	1	0
EXOC6B	23233	broad.mit.edu	37	2	72968471	72968471	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr2:72968471C>G	ENST00000272427.6	-	2	371	c.241G>C	c.(241-243)Gaa>Caa	p.E81Q	EXOC6B_ENST00000410104.1_Missense_Mutation_p.E81Q	NM_015189.1	NP_056004.1	Q9Y2D4	EXC6B_HUMAN	exocyst complex component 6B	81					protein transport|vesicle docking involved in exocytosis	exocyst				breast(1)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)	10						TTCAGCAGTTCAGTTATAGAG	0.418000													32	144					0	0	1	0	0
PSG4	5672	broad.mit.edu	37	19	43699264	43699264	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr19:43699264C>T	ENST00000405312.3	-	4	1108	c.871G>A	c.(871-873)Gaa>Aaa	p.E291K	PSG4_ENST00000244295.9_Intron|PSG4_ENST00000433626.2_Missense_Mutation_p.E198K	NM_002780.3	NP_002771.2	Q00888	PSG4_HUMAN	pregnancy specific beta-1-glycoprotein 4	291	Ig-like C2-type 2.				defense response|female pregnancy	extracellular region				central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(10)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	24		Prostate(69;0.00682)				ATCCTGTTTTCAATGGGTCGC	0.473000													55	306					0	0	1	0	0
NTNG2	84628	broad.mit.edu	37	9	135102294	135102294	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr9:135102294G>A	ENST00000393229.3	+	4	1692	c.916G>A	c.(916-918)Gag>Aag	p.E306K	NTNG2_ENST00000393228.4_Missense_Mutation_p.E306K|NTNG2_ENST00000372179.3_Missense_Mutation_p.E306K|NTNG2_ENST00000360670.3_Missense_Mutation_p.E306K	NM_032536.2	NP_115925.2	Q96CW9	NTNG2_HUMAN	netrin G2	306	Laminin EGF-like 1.				axonogenesis	anchored to plasma membrane				central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	29				OV - Ovarian serous cystadenocarcinoma(145;1.23e-05)|Epithelial(140;0.000173)		CCTGCAGTGCGAGTGCGAGCA	0.657000													7	18					0	0	1	0	0
DEAF1	10522	broad.mit.edu	37	11	687913	687913	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr11:687913G>C	ENST00000382409.3	-	4	1146	c.662C>G	c.(661-663)tCa>tGa	p.S221*	DEAF1_ENST00000338675.6_Nonsense_Mutation_p.S221*	NM_021008.2	NP_066288.2	O75398	DEAF1_HUMAN	DEAF1 transcription factor	221	SAND.				embryonic skeletal system development|germ cell development|neural tube closure|regulation of mammary gland epithelial cell proliferation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|extracellular region|nucleus	protein binding|zinc ion binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)	24		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;1.76e-27)|Epithelial(43;8.42e-27)|OV - Ovarian serous cystadenocarcinoma(40;6.55e-21)|BRCA - Breast invasive adenocarcinoma(625;4.83e-05)|Lung(200;0.0259)|LUSC - Lung squamous cell carcinoma(625;0.075)		GTCCTCACCTGAGCCGAGCCT	0.517000													10	51					0	0	1	0	0
DNAJB11	51726	broad.mit.edu	37	3	186302284	186302284	+	Silent	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr3:186302284C>T	ENST00000439351.1	+	10	1847	c.918C>T	c.(916-918)ctC>ctT	p.L306L	DNAJB11_ENST00000265028.3_Silent_p.L306L			Q9UBS4	DJB11_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 11	306					protein folding	endoplasmic reticulum lumen	heat shock protein binding			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|urinary_tract(2)	15	all_cancers(143;2.84e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.44e-20)	GBM - Glioblastoma multiforme(93;0.0476)		GGGAAGGGCTCCCCAACTTTG	0.453000													5	65					0	0	1	0	0
GUCY1A3	2982	broad.mit.edu	37	4	156632234	156632234	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr4:156632234G>A	ENST00000296518.7	+	6	1126	c.917G>A	c.(916-918)aGa>aAa	p.R306K	GUCY1A3_ENST00000513574.1_Missense_Mutation_p.R306K|GUCY1A3_ENST00000455639.2_Missense_Mutation_p.R306K|GUCY1A3_ENST00000506455.1_Missense_Mutation_p.R306K|GUCY1A3_ENST00000511507.1_Missense_Mutation_p.R306K|GUCY1A3_ENST00000393832.3_Missense_Mutation_p.R48K|GUCY1A3_ENST00000511108.1_Missense_Mutation_p.R306K			Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3	306					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|liver(2)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		AATGGCATCAGAAGGCTGATG	0.403000													17	61					0	0	1	0	0
OR2M7	391196	broad.mit.edu	37	1	248487009	248487009	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr1:248487009G>C	ENST00000317965.2	-	1	890	c.862C>G	c.(862-864)Ctc>Gtc	p.L288V		NM_001004691.1	NP_001004691.1	Q8NG81	OR2M7_HUMAN	olfactory receptor, family 2, subfamily M, member 7	288					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(6)|large_intestine(3)|lung(29)|skin(3)	42	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CTATAAATGAGAGGATTCAGC	0.423000													22	69					0	0	1	0	0
SCAF8	22828	broad.mit.edu	37	6	155143453	155143453	+	Silent	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr6:155143453C>T	ENST00000367178.3	+	16	2412	c.1836C>T	c.(1834-1836)gtC>gtT	p.V612V	SCAF8_ENST00000367186.4_Silent_p.V678V|SCAF8_ENST00000417268.1_Silent_p.V612V	NM_014892.3	NP_055707.3	Q9UPN6	SCAF8_HUMAN	SR-related CTD-associated factor 8	612					mRNA processing|RNA splicing	nuclear matrix|spliceosomal complex	nucleotide binding|RNA binding|RNA polymerase core enzyme binding			breast(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(15)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	46						AAGAGACGGTCCAGACAACTC	0.433000													5	110					0	0	1	0	0
RHPN2	85415	broad.mit.edu	37	19	33482768	33482768	+	Silent	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr19:33482768G>A	ENST00000254260.3	-	13	1640	c.1605C>T	c.(1603-1605)ccC>ccT	p.P535P	RHPN2_ENST00000400226.4_Silent_p.P384P	NM_033103.4	NP_149094.3	Q8IUC4	RHPN2_HUMAN	rhophilin, Rho GTPase binding protein 2	535	PDZ.				signal transduction	perinuclear region of cytoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(5)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(3)|skin(3)|urinary_tract(1)	44	Esophageal squamous(110;0.137)					GAACCTGAACGGGGGCGTTCC	0.517000													13	58					0	0	1	0	0
ATP2B2	491	broad.mit.edu	37	3	10420934	10420934	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr3:10420934C>G	ENST00000360273.2	-	9	1473	c.1035G>C	c.(1033-1035)caG>caC	p.Q345H	ATP2B2_ENST00000352432.4_Missense_Mutation_p.Q345H|ATP2B2_ENST00000343816.4_Intron|ATP2B2_ENST00000397077.1_Intron|ATP2B2_ENST00000383800.4_Intron	NM_001001331.2	NP_001001331.1	Q01814	AT2B2_HUMAN	ATPase, Ca++ transporting, plasma membrane 2	345					ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|large_intestine(19)|lung(29)|ovary(5)|prostate(2)|skin(4)|stomach(2)|urinary_tract(2)	74						TACCTTTGCTCTGGCTGGCGT	0.522000													11	17					0	0	1	0	0
WHSC1	7468	broad.mit.edu	37	4	1941403	1941403	+	Silent	SNP	A	A	G			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr4:1941403A>G	ENST00000503128.1	+	9	1986	c.1779A>G	c.(1777-1779)gcA>gcG	p.A593A	WHSC1_ENST00000482415.2_3'UTR|WHSC1_ENST00000508803.1_Silent_p.A593A|WHSC1_ENST00000514045.1_Silent_p.A593A|WHSC1_ENST00000382895.3_Silent_p.A593A|WHSC1_ENST00000398261.1_Silent_p.A593A|WHSC1_ENST00000382892.2_Silent_p.A593A|WHSC1_ENST00000382891.5_Silent_p.A593A|WHSC1_ENST00000420906.2_Silent_p.A593A			O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1	593					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(14)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	48		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		TGTCTGATGCATGTAAACCAC	0.378000			T	IGH@	MM								10	48					0	0	1	0	0
KBTBD8	84541	broad.mit.edu	37	3	67049505	67049505	+	Silent	SNP	C	C	G			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr3:67049505C>G	ENST00000295568.4	+	2	170	c.39C>G	c.(37-39)ctC>ctG	p.L13L	KBTBD8_ENST00000460576.1_Intron|KBTBD8_ENST00000417314.2_Silent_p.L39L|KBTBD8_ENST00000469661.1_3'UTR	NM_032505.2	NP_115894.2	Q8NFY9	KBTB8_HUMAN	kelch repeat and BTB (POZ) domain containing 8	39										breast(1)|endometrium(1)|kidney(4)|large_intestine(7)|lung(4)|ovary(2)|prostate(1)	20		Lung NSC(201;0.0765)		BRCA - Breast invasive adenocarcinoma(55;6.02e-06)|KIRC - Kidney renal clear cell carcinoma(39;0.105)|Kidney(39;0.125)		TTAAGCAACTCAAAACAATGT	0.453000													10	40					0	0	1	0	0
KLHL1	57626	broad.mit.edu	37	13	70514196	70514196	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr13:70514196C>T	ENST00000377844.4	-	4	1749	c.990G>A	c.(988-990)atG>atA	p.M330I	KLHL1_ENST00000545028.1_Missense_Mutation_p.M137I	NM_020866.2	NP_065917.1	Q9NR64	KLHL1_HUMAN	kelch-like family member 1	330					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding	p.M330I(1)		breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(56)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	84		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		GGGCCACCTTCATTAACTCAA	0.413000													7	34					0	0	1	0	0
LACRT	90070	broad.mit.edu	37	12	55026033	55026033	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr12:55026033T>C	ENST00000257867.4	-	3	298	c.245A>G	c.(244-246)aAc>aGc	p.N82S	LACRT_ENST00000547511.1_Missense_Mutation_p.N82S	NM_033277.1	NP_150593.1	Q9GZZ8	LACRT_HUMAN	lacritin	82					calcineurin-NFAT signaling pathway|positive regulation of epithelial cell proliferation|positive regulation of NFAT protein import into nucleus|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of secretion|protein localization in Golgi apparatus|tear secretion	extracellular region|stored secretory granule	collagen binding|fibronectin binding|glycoprotein binding|growth factor activity|laminin-1 binding|protein N-terminus binding			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(1)|lung(4)|stomach(1)	10						ACTCAGGGGGTTTAGTTCCTG	0.557000													21	75					0	0	1	0	0
DZIP1	22873	broad.mit.edu	37	13	96242575	96242575	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr13:96242575G>C	ENST00000347108.3	-	15	2233	c.1801C>G	c.(1801-1803)Caa>Gaa	p.Q601E	DZIP1_ENST00000361396.2_Missense_Mutation_p.Q582E|DZIP1_ENST00000376829.2_Missense_Mutation_p.Q601E|DZIP1_ENST00000361156.3_Missense_Mutation_p.Q582E			Q86YF9	DZIP1_HUMAN	DAZ interacting zinc finger protein 1	601					germ cell development|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleic acid binding|protein binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(20)|lung(11)|ovary(2)|pancreas(1)|skin(1)|stomach(1)	38	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.141)			CAGCTGACTTGATGTTCAAGG	0.348000													17	99					0	0	1	0	0
SLC32A1	140679	broad.mit.edu	37	20	37356388	37356388	+	Silent	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr20:37356388C>T	ENST00000217420.1	+	2	947	c.684C>T	c.(682-684)ctC>ctT	p.L228L		NM_080552.2	NP_542119.1	Q9H598	VIAAT_HUMAN	solute carrier family 32 (GABA vesicular transporter), member 1	228					neurotransmitter secretion	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|integral to membrane|plasma membrane|synaptic vesicle membrane	vesicular hydrogen:amino acid antiporter activity			breast(2)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(11)|lung(16)|urinary_tract(1)	38		Myeloproliferative disorder(115;0.00878)			Glycine(DB00145)	GTGGCAACCTCATGTACAACA	0.617000													16	50					0	0	1	0	0
FOXG1	2290	broad.mit.edu	37	14	29237845	29237845	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr14:29237845G>C	ENST00000382535.3	+	2	1729	c.1360G>C	c.(1360-1362)Gag>Cag	p.E454Q	FOXG1_ENST00000313071.4_Missense_Mutation_p.E454Q			P55316	FOXG1_HUMAN	forkhead box G1	454					axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(23)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(2)	43			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)		CCTGCCCTGTGAGTCTTTAAG	0.582000													13	66					0	0	1	0	0
DCBLD1	285761	broad.mit.edu	37	6	117866741	117866741	+	Silent	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr6:117866741C>T	ENST00000338728.5	+	14	1716	c.1596C>T	c.(1594-1596)ctC>ctT	p.L532L	DCBLD1_ENST00000296955.8_Silent_p.L532L|DCBLD1_ENST00000534777.1_3'UTR|GOPC_ENST00000467125.1_Intron|DCBLD1_ENST00000368503.4_Silent_p.L333L			Q8N8Z6	DCBD1_HUMAN	discoidin, CUB and LCCL domain containing 1	532					cell adhesion	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(15)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	26		all_cancers(87;0.171)		GBM - Glioblastoma multiforme(226;0.0447)|OV - Ovarian serous cystadenocarcinoma(136;0.0921)|all cancers(137;0.125)		AGTTAGATCTCATCACAAGTG	0.428000													29	76					0	0	1	0	0
VPS13B	157680	broad.mit.edu	37	8	100523670	100523670	+	Silent	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr8:100523670G>A	ENST00000358544.2	+	29	4749	c.4638G>A	c.(4636-4638)ttG>ttA	p.L1546L	VPS13B_ENST00000395996.1_3'UTR|VPS13B_ENST00000357162.2_Silent_p.L1521L	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	1546					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			ATTTACCTTTGATTTATGTCA	0.358000													9	21					0	0	1	0	0
IGSF10	285313	broad.mit.edu	37	3	151162930	151162930	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr3:151162930C>G	ENST00000282466.3	-	4	4838	c.4839G>C	c.(4837-4839)caG>caC	p.Q1613H		NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	1613					cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TTGTGTTCTTCTGTCCATCCC	0.413000													26	111					0	0	1	0	0
KNTC1	9735	broad.mit.edu	37	12	123082440	123082440	+	Silent	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr12:123082440G>A	ENST00000333479.7	+	44	4695	c.4518G>A	c.(4516-4518)acG>acA	p.T1506T	KNTC1_ENST00000450485.2_Intron|KNTC1_ENST00000545065.1_3'UTR	NM_014708.4	NP_055523.1	P50748	KNTC1_HUMAN	kinetochore associated 1	1506			T -> M (in dbSNP:rs35315099).		cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(12)|kidney(8)|large_intestine(12)|lung(20)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	72	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		CTTTACTGACGAGCACAAAAG	0.502000													18	84					0	0	1	0	0
CEP350	9857	broad.mit.edu	37	1	180064688	180064688	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr1:180064688G>A	ENST00000367607.3	+	35	8960	c.8542G>A	c.(8542-8544)Gaa>Aaa	p.E2848K	CEP350_ENST00000490141.1_3'UTR	NM_014810.4	NP_055625.4	Q5VT06	CE350_HUMAN	centrosomal protein 350kDa	2848						centrosome|nucleus|spindle				central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	66						CAGTGGGCAGGAAGAACTTGC	0.433000													5	77					0	0	1	0	0
DCAF12	25853	broad.mit.edu	37	9	34107496	34107496	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr9:34107496C>G	ENST00000361264.4	-	3	742	c.401G>C	c.(400-402)gGa>gCa	p.G134A	DCAF12_ENST00000463286.1_5'UTR	NM_015397.3	NP_056212.1	Q5T6F0	DCA12_HUMAN	DDB1 and CUL4 associated factor 12	134						centrosome|CUL4 RING ubiquitin ligase complex				breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|prostate(1)	11						GGTCACACCTCCAGGCTCCCG	0.502000													15	60					0	0	1	0	0
MKL2	57496	broad.mit.edu	37	16	14340402	14340402	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr16:14340402C>T	ENST00000571589.1	+	12	1457	c.1285C>T	c.(1285-1287)Cgc>Tgc	p.R429C	MKL2_ENST00000341243.5_Missense_Mutation_p.R418C|MKL2_ENST00000574045.1_Missense_Mutation_p.R429C|MKL2_ENST00000318282.5_Missense_Mutation_p.R429C	NM_014048.3	NP_054767.3	Q9ULH7	MKL2_HUMAN	MKL/myocardin-like 2	418					cell differentiation|muscle organ development|positive regulation of striated muscle tissue development|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		identical protein binding|nucleic acid binding|transcription coactivator activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(6)|liver(2)|lung(7)|ovary(4)|pancreas(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						CCTCATTGAGCGCCTAAAACC	0.517000													14	57					0	0	1	0	0
ZNF131	7690	broad.mit.edu	37	5	43139394	43139394	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr5:43139394C>G	ENST00000509634.1	+	3	810	c.354C>G	c.(352-354)atC>atG	p.I118M	ZNF131_ENST00000399534.1_Missense_Mutation_p.I118M|ZNF131_ENST00000505606.2_Missense_Mutation_p.I118M|ZNF131_ENST00000509931.1_Intron|ZNF131_ENST00000509156.1_Missense_Mutation_p.I118M|ZNF131_ENST00000306938.4_Missense_Mutation_p.I118M			P52739	ZN131_HUMAN	zinc finger protein 131	118						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	17						TAGAAGCTATCAAAGCCCTTG	0.348000													24	80					0	0	1	0	0
NBPF1	55672	broad.mit.edu	37	1	16902807	16902807	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr1:16902807C>T	ENST00000430580.2	-	19	2961	c.2074G>A	c.(2074-2076)Gag>Aag	p.E692K	NBPF1_ENST00000432949.1_Missense_Mutation_p.E150K|NBPF1_ENST00000287968.8_Missense_Mutation_p.E57K	NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1	692						cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		CTACACCCCTCAGCCAGCTGT	0.577000													28	918					0	0	1	0	0
PCDHA7	56141	broad.mit.edu	37	5	140214112	140214112	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr5:140214112C>G	ENST00000525929.1	+	1	144	c.144C>G	c.(142-144)atC>atG	p.I48M	PCDHA1_ENST00000504120.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA7_ENST00000378125.3_Missense_Mutation_p.I48M|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA4_ENST00000512229.2_Intron	NM_018910.2	NP_061733.1														NS(2)|biliary_tract(1)|breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGGCCGCATCGCGCAGGACC	0.597000													57	159					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152522033	152522033	+	Silent	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr2:152522033G>A	ENST00000427231.2	-	42	5254	c.5052C>T	c.(5050-5052)ttC>ttT	p.F1684F	NEB_ENST00000409198.1_Silent_p.F1684F|NEB_ENST00000604864.1_Silent_p.F1684F|NEB_ENST00000172853.10_Silent_p.F1684F|NEB_ENST00000397345.3_Silent_p.F1684F|NEB_ENST00000603639.1_Silent_p.F1684F	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	1684					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		TCCAATTGGTGAAGTCAGATT	0.413000													7	17					0	0	1	0	0
GFM2	84340	broad.mit.edu	37	5	74041581	74041581	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr5:74041581C>G	ENST00000296805.3	-	10	1228	c.771G>C	c.(769-771)gaG>gaC	p.E257D	GFM2_ENST00000345239.2_Missense_Mutation_p.E257D|GFM2_ENST00000509430.1_Missense_Mutation_p.E257D|GFM2_ENST00000427854.2_Missense_Mutation_p.E257D	NM_032380.3	NP_115756.2	Q969S9	RRF2M_HUMAN	G elongation factor, mitochondrial 2	257					mitochondrial translation|ribosome disassembly	mitochondrion	GTP binding|GTPase activity			breast(2)|endometrium(2)|large_intestine(4)|lung(5)|prostate(1)	14		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Breast(144;0.231)		OV - Ovarian serous cystadenocarcinoma(47;1.86e-56)		GGGGCTTTCTCTCAAAGTCTT	0.348000													12	34					0	0	1	0	0
GAPDH	2597	broad.mit.edu	37	12	6646377	6646377	+	Silent	SNP	C	C	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr12:6646377C>A	ENST00000229239.5	+	6	1104	c.438C>A	c.(436-438)atC>atA	p.I146I	GAPDH_ENST00000396861.1_Silent_p.I146I|GAPDH_ENST00000396859.1_Silent_p.I146I|GAPDH_ENST00000396856.1_Silent_p.I71I|GAPDH_ENST00000396858.1_Silent_p.I104I	NM_002046.4	NP_002037.2	P04406	G3P_HUMAN	glyceraldehyde-3-phosphate dehydrogenase	146	Interaction with WARS.				gluconeogenesis|glycolysis|neuron apoptosis|peptidyl-cysteine S-trans-nitrosylation|protein stabilization	cytosol|membrane|nucleus|perinuclear region of cytoplasm	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity|NAD binding|peptidyl-cysteine S-nitrosylase activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|lung(4)	7					NADH(DB00157)	GCCTCAAGATCATCAGGTGAG	0.592000													6	47					0.00307968	0.00310452	1	1	0
MORN5	254956	broad.mit.edu	37	9	124929130	124929130	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr9:124929130G>A	ENST00000536616.1	+	2	169	c.131G>A	c.(130-132)gGa>gAa	p.G44E	MORN5_ENST00000486801.1_3'UTR|MORN5_ENST00000373764.3_Missense_Mutation_p.G44E			Q5VZ52	MORN5_HUMAN	MORN repeat containing 5	44										endometrium(3)|kidney(1)|large_intestine(3)|lung(1)|skin(1)	9						CACGGCGAGGGAACCCTGTAC	0.527000													8	33					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11058248	11058248	+	RNA	SNP	G	G	A	rs8130203	by1000genomes	TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr21:11058248G>A	ENST00000470054.1	-	0	399									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GCAGCACAAGGATAATGATAC	0.433000													5	127					0	0	1	0	0
TOM1L2	146691	broad.mit.edu	37	17	17783023	17783023	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr17:17783023C>T	ENST00000581396.1	-	6	641	c.545G>A	c.(544-546)cGa>cAa	p.R182Q	TOM1L2_ENST00000535933.1_Missense_Mutation_p.R179Q|TOM1L2_ENST00000395739.4_Missense_Mutation_p.R187Q|TOM1L2_ENST00000542206.1_Missense_Mutation_p.R84Q|TOM1L2_ENST00000379504.3_Missense_Mutation_p.R232Q|TOM1L2_ENST00000318094.10_Missense_Mutation_p.R187Q|TOM1L2_ENST00000540946.1_Missense_Mutation_p.R134Q	NM_001033551.2	NP_001028723.1	Q6ZVM7	TM1L2_HUMAN	target of myb1-like 2 (chicken)	232					intracellular protein transport	intracellular				endometrium(2)|kidney(2)|large_intestine(1)|lung(3)|prostate(2)	10	all_neural(463;0.228)					TGTGTTTCCTCGAACGACGTC	0.507000													26	102					0	0	1	0	0
CNGA3	1261	broad.mit.edu	37	2	99012614	99012614	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr2:99012614delC	ENST00000393504.1	+	8	1398	c.981delC	c.(979-981)ttfs	p.F327fs	CNGA3_ENST00000272602.2_Frame_Shift_Del_p.F327fs|CNGA3_ENST00000409937.1_Frame_Shift_Del_p.F331fs|CNGA3_ENST00000436404.2_Frame_Shift_Del_p.F309fs	NM_001298.2	NP_001289.1	Q16281	CNGA3_HUMAN	cyclic nucleotide gated channel alpha 3	327					signal transduction|visual perception	integral to membrane	cGMP binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(10)|lung(17)|ovary(5)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)	49						TTTCCAAGTTCATTGGTTTTG	0.478													19	112	---	---	---	---					
STAG3L2	442582	broad.mit.edu	37	7	74300804	74300804	+	RNA	DEL	A	A	-			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr7:74300804delA	ENST00000423186.1	-	0	499							P0CL84	ST3L2_HUMAN								nucleus	binding			breast(1)|central_nervous_system(1)|large_intestine(1)|lung(1)|pancreas(1)	5						CTTCATACTTAAAAAAAAAAA	0.458													2	4	---	---	---	---					
ZNF750	79755	broad.mit.edu	37	17	80789724	80789725	+	Frame_Shift_Del	DEL	GA	GA	-			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr17:80789724_80789725delGA	ENST00000269394.3	-	2	1439_1440	c.606_607delTC	c.(604-609)acctfs	p.TP202fs	TBCD_ENST00000397466.2_Intron|TBCD_ENST00000355528.4_Intron|ZNF750_ENST00000572562.1_Intron|TBCD_ENST00000539345.2_Intron	NM_024702.2	NP_078978.2	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	202						intracellular	zinc ion binding			NS(3)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|large_intestine(4)|lung(12)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	31	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)			GGGTAGCCAGGAGTGTGGAAGG	0.569													25	43	---	---	---	---					
TMC4	147798	broad.mit.edu	37	19	54675747	54675749	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-CN-A63Y-01A-11D-A30E-08	TCGA-CN-A63Y-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1573766d-cd60-4498-bdad-dcb8d6bc88c8	8582b1ee-b97e-42ab-be9f-5d3899704723	g.chr19:54675747_54675749delTCC	ENST00000376591.4	-	2	332_334	c.201_203delGGA	c.(199-204)gat>ga	p.ED67del	TMC4_ENST00000301187.4_In_Frame_Del_p.ED61del	NM_001145303.1|NM_144686.2	NP_001138775.1|NP_653287.1	Q7Z404	TMC4_HUMAN	transmembrane channel-like 4	67	Poly-Glu.					integral to membrane				breast(2)|endometrium(7)|large_intestine(4)|lung(6)|pancreas(1)|skin(1)|urinary_tract(1)	22	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					CCTTCCTCCATCCTCCTCCTCCT	0.645													8	108	---	---	---	---