Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MTNR1A	4543	broad.mit.edu	37	4	187454891	187454891	+	Silent	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr4:187454891C>T	ENST00000307161.5	-	2	1206	c.1005G>A	c.(1003-1005)ccG>ccA	p.P335P	RP11-215A19.2_ENST00000509111.1_Intron	NM_005958.3	NP_005949.1	P48039	MTR1A_HUMAN	melatonin receptor 1A	335					circadian rhythm|G-protein signaling, coupled to cyclic nucleotide second messenger|mating behavior	integral to plasma membrane	melatonin receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	14		all_cancers(14;6.39e-56)|all_epithelial(14;1.48e-41)|all_lung(41;2.45e-15)|Lung NSC(41;7.26e-15)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00335)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|Renal(120;0.0183)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;7.63e-12)|BRCA - Breast invasive adenocarcinoma(30;6.68e-07)|GBM - Glioblastoma multiforme(59;3.44e-05)|LUSC - Lung squamous cell carcinoma(40;0.000106)|STAD - Stomach adenocarcinoma(60;0.000279)|READ - Rectum adenocarcinoma(43;0.159)	Melatonin(DB01065)|Ramelteon(DB00980)	TCAGTGGAGACGGTTTCCATT	0.493000													24	68					0	0	0.003330	0	0
DMD	1756	broad.mit.edu	37	X	32591889	32591889	+	Silent	SNP	G	G	C			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chrX:32591889G>C	ENST00000357033.4	-	14	1883	c.1677C>G	c.(1675-1677)ctC>ctG	p.L559L	DMD_ENST00000378677.2_Silent_p.L555L|DMD_ENST00000288447.4_Silent_p.L551L	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	559					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				GTTGCCATTTGAGAAGGATGT	0.423000													7	6					0	0	0.003080	0	0
SBF2	81846	broad.mit.edu	37	11	10022466	10022466	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr11:10022466C>G	ENST00000256190.8	-	8	993	c.856G>C	c.(856-858)Gaa>Caa	p.E286Q	SBF2_ENST00000527019.1_5'UTR	NM_030962.3	NP_112224.1	Q86WG5	MTMRD_HUMAN	SET binding factor 2	286	DENN.				myelination	cytoplasm|membrane	phosphatase activity|protein binding			breast(4)|endometrium(8)|kidney(2)|large_intestine(8)|lung(16)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48				all cancers(16;2.88e-11)|Epithelial(150;3.61e-10)|BRCA - Breast invasive adenocarcinoma(625;0.00887)		CTTACAAGTTCATGGACATCA	0.363000													3	6					0	0	0.004672	0	0
CCDC66	285331	broad.mit.edu	37	3	56651600	56651600	+	Silent	SNP	G	G	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr3:56651600G>A	ENST00000394672.3	+	14	2374	c.2304G>A	c.(2302-2304)acG>acA	p.T768T	CCDC66_ENST00000326595.7_Silent_p.T734T|CCDC66_ENST00000436465.2_Silent_p.T768T	NM_001012506.4|NM_001141947.1	NP_001012524.4|NP_001135419.1	A2RUB6	CCD66_HUMAN	coiled-coil domain containing 66	768										breast(1)|kidney(1)|large_intestine(2)|liver(1)|lung(4)|skin(2)|urinary_tract(1)	12				KIRC - Kidney renal clear cell carcinoma(284;0.0478)|Kidney(284;0.0597)|OV - Ovarian serous cystadenocarcinoma(275;0.233)		ATCAAGAAACGGAGTCAAAGT	0.378000													10	15					0	0	0.008291	0	0
SI	6476	broad.mit.edu	37	3	164777066	164777066	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr3:164777066C>G	ENST00000264382.3	-	11	1230	c.1168G>C	c.(1168-1170)Gac>Cac	p.D390H		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	390	Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TCCATGTAGTCAATATCAGTG	0.358000										HNSCC(35;0.089)			7	52					0	0	0.003080	0	0
ERMARD	55780	broad.mit.edu	37	6	170156467	170156467	+	Silent	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr6:170156467C>T	ENST00000366773.3	+	4	382	c.349C>T	c.(349-351)Cta>Tta	p.L117L	C6orf70_ENST00000418781.3_Silent_p.L117L|C6orf70_ENST00000392095.4_5'UTR|C6orf70_ENST00000588451.1_5'UTR|C6orf70_ENST00000366772.2_Silent_p.L117L	NM_001278532.1|NM_018341.1	NP_001265461.1|NP_060811.1	Q5T6L9	CF070_HUMAN		117						integral to membrane				breast(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(7)|ovary(1)	20		Breast(66;5.08e-05)|Ovarian(120;0.208)		OV - Ovarian serous cystadenocarcinoma(33;1.2e-22)|BRCA - Breast invasive adenocarcinoma(81;1.49e-07)|GBM - Glioblastoma multiforme(31;0.00191)		CTTGGAAAGTCTACAATCTCC	0.348000													9	48					0	0	0.006214	0	0
TP53	7157	broad.mit.edu	37	17	7577022	7577022	+	Nonsense_Mutation	SNP	G	G	A	rs121913344		TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr17:7577022G>A	ENST00000420246.2	-	8	1048	c.916C>T	c.(916-918)Cga>Tga	p.R306*	TP53_ENST00000359597.4_Nonsense_Mutation_p.R306*|TP53_ENST00000455263.2_Nonsense_Mutation_p.R306*|TP53_ENST00000269305.4_Nonsense_Mutation_p.R306*|TP53_ENST00000413465.2_Intron|TP53_ENST00000445888.2_Nonsense_Mutation_p.R306*	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	306	Interaction with CARM1.|Interaction with HIPK1 (By similarity).		R -> P (in LFS; germline mutation and in a sporadic cancer; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R306*(133)|p.0?(8)|p.?(3)|p.R306fs*39(2)|p.K305fs*1(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGCTTACCTCGCTTAGTGCTC	0.562000	R306*(HCC1937_BREAST)|R306*(JURLMK1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R306*(MFE296_ENDOMETRIUM)|R306*(MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R306*(RCM1_LARGE_INTESTINE)	111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			53	31					0	0	0.014410	0	0
SIGLEC10	89790	broad.mit.edu	37	19	51914354	51914354	+	Silent	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr19:51914354C>T	ENST00000353836.5	-	10	2029	c.1808G>A	c.(1807-1809)tGa>tAa	p.*603*	SIGLEC10_ENST00000525998.1_Silent_p.*513*|SIGLEC10_ENST00000432469.2_Silent_p.*520*|SIGLEC10_ENST00000439889.2_Silent_p.*640*|SIGLEC10_ENST00000436984.2_Silent_p.*555*|SIGLEC10_ENST00000441969.3_Silent_p.*545*|SIGLEC10_ENST00000356298.5_Silent_p.*698*|SIGLEC10_ENST00000442846.3_Silent_p.*455*|SIGLEC10_ENST00000339313.5_Silent_p.*698*	NM_001171157.1|NM_001171158.1|NM_001171159.1	NP_001164628.1|NP_001164629.1|NP_001164630.1	Q96LC7	SIG10_HUMAN	sialic acid binding Ig-like lectin 10	0					cell adhesion	extracellular region|integral to membrane|plasma membrane	sugar binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(27)|ovary(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000668)|OV - Ovarian serous cystadenocarcinoma(262;0.0101)		AAGAGACCCTCATTGGAACTT	0.542000													61	38					0	0	0.014410	0	0
RHOA	387	broad.mit.edu	37	3	49412905	49412905	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr3:49412905C>G	ENST00000418115.1	-	2	502	c.118G>C	c.(118-120)Gag>Cag	p.E40Q	RHOA_ENST00000454011.2_Missense_Mutation_p.E40Q|RHOA_ENST00000422781.1_Missense_Mutation_p.E40Q	NM_001664.2	NP_001655.1	P61586	RHOA_HUMAN	ras homolog family member A	40					axon guidance|interspecies interaction between organisms|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of axonogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of neuron differentiation|positive regulation of NF-kappaB import into nucleus|positive regulation of stress fiber assembly|regulation of cell migration|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|spindle assembly involved in mitosis	cytoskeleton|cytosol|plasma membrane	GTP binding|GTPase activity|myosin binding	p.E40Q(1)		cervix(1)|kidney(1)|large_intestine(5)|lung(1)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	12				BRCA - Breast invasive adenocarcinoma(193;8.58e-05)|Kidney(197;0.0023)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)	Atorvastatin(DB01076)|Simvastatin(DB00641)	ACATAGTTCTCAAACACTGTG	0.438000													87	46					0	0	0.014410	0	0
USP26	83844	broad.mit.edu	37	X	132161099	132161099	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chrX:132161099G>C	ENST00000511190.1	-	6	1619	c.1150C>G	c.(1150-1152)Cat>Gat	p.H384D	USP26_ENST00000406273.1_Missense_Mutation_p.H384D|USP26_ENST00000370832.1_Missense_Mutation_p.H384D	NM_031907.1	NP_114113.1	Q9BXU7	UBP26_HUMAN	ubiquitin specific peptidase 26	384					protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity	p.H384Y(1)		breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(11)|liver(2)|lung(18)|ovary(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	60	Acute lymphoblastic leukemia(192;0.000127)					AAAAACTCATGAGCATCGTTC	0.358000													24	14					0	0	0.003954	0	0
CIT	11113	broad.mit.edu	37	12	120172072	120172072	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr12:120172072G>A	ENST00000392521.2	-	26	3302	c.3247C>T	c.(3247-3249)Cgg>Tgg	p.R1083W	CIT_ENST00000261833.7_Missense_Mutation_p.R1041W|CIT_ENST00000537607.1_5'UTR	NM_001206999.1	NP_001193928.1	O14578	CTRO_HUMAN	citron (rho-interacting, serine/threonine kinase 21)	1041					intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			breast(6)|endometrium(9)|kidney(4)|large_intestine(15)|liver(1)|lung(29)|ovary(7)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	86	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		TCCCACTGCCGCTCTTTTTCT	0.547000													34	42					0	0	0.003755	0	0
KIAA1211	57482	broad.mit.edu	37	4	57182124	57182124	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr4:57182124C>T	ENST00000504228.1	+	6	2561	c.2456C>T	c.(2455-2457)tCg>tTg	p.S819L	KIAA1211_ENST00000264229.6_Missense_Mutation_p.S819L|KIAA1211_ENST00000541073.1_Missense_Mutation_p.S812L			Q6ZU35	K1211_HUMAN	KIAA1211	819										endometrium(7)|large_intestine(10)|lung(39)|ovary(2)|prostate(3)|skin(3)|stomach(1)	65	Glioma(25;0.08)|all_neural(26;0.101)					TTCACGACCTCGTCGGACAGC	0.537000													25	54					0	0	0.003954	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125282021	125282021	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr2:125282021A>G	ENST00000431078.1	+	9	1830	c.1466A>G	c.(1465-1467)tAt>tGt	p.Y489C		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	489	Laminin G-like 2.				cell adhesion|signal transduction	integral to membrane	receptor binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		AATAGCTACTATTTTGGAGGT	0.448000													16	19					0	0	0.004007	0	0
PDE8B	8622	broad.mit.edu	37	5	76704787	76704787	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr5:76704787C>G	ENST00000264917.5	+	14	1480	c.1435C>G	c.(1435-1437)Cta>Gta	p.L479V	PDE8B_ENST00000333194.4_Intron|PDE8B_ENST00000346042.3_Missense_Mutation_p.L382V|PDE8B_ENST00000342343.4_Missense_Mutation_p.L459V|PDE8B_ENST00000340978.3_Missense_Mutation_p.L432V	NM_003719.3	NP_003710.1	O95263	PDE8B_HUMAN	phosphodiesterase 8B	479					cyclic nucleotide metabolic process|regulation of transcription, DNA-dependent	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|two-component response regulator activity		GMDS/PDE8B(2)	NS(1)|autonomic_ganglia(2)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(10)|lung(15)|ovary(1)|prostate(2)|skin(3)	40		all_lung(232;0.00043)|Lung NSC(167;0.00114)|Ovarian(174;0.0107)|Prostate(461;0.0605)		OV - Ovarian serous cystadenocarcinoma(54;2.21e-49)|Epithelial(54;5.82e-43)|all cancers(79;4.06e-38)		GGACAGAGTTCTAGAGATTTT	0.463000													12	38					0	0	0.013537	0	0
CNGB3	54714	broad.mit.edu	37	8	87638274	87638274	+	Silent	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr8:87638274C>T	ENST00000320005.5	-	13	1562	c.1515G>A	c.(1513-1515)acG>acA	p.T505T		NM_019098.4	NP_061971.3	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	505					signal transduction|visual perception	integral to membrane	cGMP binding			NS(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(15)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	80						CTAACTGGACCGTAGTTGGTA	0.383000													20	42					0	0	0.010504	0	0
SSPO	23145	broad.mit.edu	37	7	149486777	149486777	+	RNA	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr7:149486777C>T	ENST00000378016.2	+	0	4551							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			TCTGGGACTGCCCAGATGGAG	0.667000													9	16					0	0	0.006214	0	0
TCERG1	10915	broad.mit.edu	37	5	145851118	145851118	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr5:145851118C>T	ENST00000296702.5	+	9	1618	c.1580C>T	c.(1579-1581)gCt>gTt	p.A527V	TCERG1_ENST00000394421.2_Missense_Mutation_p.A506V	NM_006706.3	NP_006697.2	O14776	TCRG1_HUMAN	transcription elongation regulator 1	527					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity			breast(1)|central_nervous_system(3)|endometrium(5)|kidney(4)|large_intestine(18)|lung(9)|ovary(2)|prostate(3)|skin(1)	46		Lung NSC(249;0.00188)|all_lung(500;0.00307)|all_neural(839;0.0424)|Breast(839;0.0743)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GTTGCTACTGCTCCTATTCCT	0.423000													16	38					0	0	0.006122	0	0
SLC2A12	154091	broad.mit.edu	37	6	134350301	134350301	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr6:134350301G>C	ENST00000275230.5	-	2	817	c.662C>G	c.(661-663)cCt>cGt	p.P221R		NM_145176.2	NP_660159.1	Q8TD20	GTR12_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 12	221						endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity			NS(1)|breast(1)|large_intestine(6)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	17	Breast(56;0.214)|Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.0101)|GBM - Glioblastoma multiforme(68;0.0123)		CAGAAACCGAGGGCTTGGAGG	0.448000													30	60					0	0	0.009535	0	0
MYRF	745	broad.mit.edu	37	11	61533490	61533490	+	Silent	SNP	G	G	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr11:61533490G>A	ENST00000278836.5	+	3	291	c.195G>A	c.(193-195)gcG>gcA	p.A65A	MYRF_ENST00000265460.5_Silent_p.A56A	NM_001127392.1	NP_001120864.1			myelin regulatory factor																		GGCAGCCTGCGATGCCTGGCT	0.746000													5	13					0	0	0.000602	0	0
PLCB4	5332	broad.mit.edu	37	20	9360788	9360788	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr20:9360788G>C	ENST00000378501.2	+	10	847	c.832G>C	c.(832-834)Gat>Cat	p.D278H	PLCB4_ENST00000378473.3_Missense_Mutation_p.D278H|PLCB4_ENST00000492632.1_3'UTR|PLCB4_ENST00000278655.4_Missense_Mutation_p.D278H|PLCB4_ENST00000378493.1_Missense_Mutation_p.D278H|PLCB4_ENST00000334005.3_Missense_Mutation_p.D278H|PLCB4_ENST00000414679.2_Missense_Mutation_p.D278H	NM_000933.3	NP_000924.3	Q15147	PLCB4_HUMAN	phospholipase C, beta 4	278					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(2)|breast(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(11)|liver(4)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(19)|upper_aerodigestive_tract(1)	87						GTATGAACCTGATGAAGATTT	0.294000													8	24					0	0	0.006214	0	0
LRRC8B	23507	broad.mit.edu	37	1	90049999	90049999	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr1:90049999T>C	ENST00000330947.2	+	5	2150	c.1790T>C	c.(1789-1791)cTg>cCg	p.L597P	LRRC8B_ENST00000439853.1_Missense_Mutation_p.L597P|RP5-1007M22.2_ENST00000443562.1_RNA|LRRC8B_ENST00000358200.4_Missense_Mutation_p.L597P	NM_001134476.1	NP_001127948.1	Q6P9F7	LRC8B_HUMAN	leucine rich repeat containing 8 family, member B	597						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(6)|kidney(5)|large_intestine(2)|lung(5)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	26		all_lung(203;0.17)		all cancers(265;0.00515)|Epithelial(280;0.0241)		AGCTGTGACCTGGAACGCATC	0.403000													3	52					0	0	0.004672	0	0
DDI2	84301	broad.mit.edu	37	1	15956839	15956839	+	Silent	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr1:15956839C>T	ENST00000480945.1	+	3	459	c.288C>T	c.(286-288)ttC>ttT	p.F96F		NM_032341.4	NP_115717.3	Q5TDH0	DDI2_HUMAN	DNA-damage inducible 1 homolog 2 (S. cerevisiae)	96					proteolysis		aspartic-type endopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(2)|lung(7)|pancreas(1)|prostate(1)|stomach(1)	17		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00327)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.03e-07)|COAD - Colon adenocarcinoma(227;4.48e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00773)|READ - Rectum adenocarcinoma(331;0.0656)		GAATAGATTTCAGTAGTATAG	0.463000													30	56					0	0	0.009535	0	0
CNTN3	5067	broad.mit.edu	37	3	74315641	74315641	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr3:74315641G>A	ENST00000263665.6	-	21	3004	c.2977C>T	c.(2977-2979)Cga>Tga	p.R993*	CNTN3_ENST00000477856.1_5'UTR	NM_020872.1	NP_065923.1	Q9P232	CNTN3_HUMAN	contactin 3 (plasmacytoma associated)	993					cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(39)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	83		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		CTGGTTATTCGTGGAATCCTG	0.428000													89	67					0	0	0.014410	0	0
MB21D2	151963	broad.mit.edu	37	3	192516654	192516654	+	Silent	SNP	G	G	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr3:192516654G>T	ENST00000392452.2	-	2	1317	c.997C>A	c.(997-999)Cgg>Agg	p.R333R		NM_178496.3	NP_848591.2	Q8IYB1	M21D2_HUMAN	Mab-21 domain containing 2	333										endometrium(3)|kidney(1)|large_intestine(4)|lung(17)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)	31						ATCATGCTCCGCAGGTGATAG	0.552000													28	82					9.04412e-07	1.04573e-06	0.004656	1	0
CPVL	54504	broad.mit.edu	37	7	29105714	29105714	+	Silent	SNP	G	G	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr7:29105714G>A	ENST00000409850.1	-	14	1534	c.888C>T	c.(886-888)ggC>ggT	p.G296G	CPVL_ENST00000265394.5_Silent_p.G296G|CPVL_ENST00000396276.3_Silent_p.G296G			Q9H3G5	CPVL_HUMAN	carboxypeptidase, vitellogenic-like	296					proteolysis		protein binding|serine-type carboxypeptidase activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|ovary(2)|prostate(1)|skin(1)	28						TTGTTAAGTCGCCATCTAGTA	0.348000													11	42					0	0	0.010729	0	0
CLEC2D	29121	broad.mit.edu	37	12	9840539	9840539	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr12:9840539C>T	ENST00000261340.7	+	3	236	c.214C>T	c.(214-216)Caa>Taa	p.Q72*	CLEC2D_ENST00000290855.6_Nonsense_Mutation_p.Q72*|CLEC2D_ENST00000261339.6_Nonsense_Mutation_p.Q35*|CLEC2D_ENST00000543300.1_Nonsense_Mutation_p.Q72*|CLEC2D_ENST00000545918.1_Nonsense_Mutation_p.Q35*	NM_001004419.4	NP_001004419.1	Q9UHP7	CLC2D_HUMAN	C-type lectin domain family 2, member D	72					cell surface receptor linked signaling pathway	cell surface|endoplasmic reticulum|integral to plasma membrane|membrane fraction	sugar binding|transmembrane receptor activity			endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|prostate(2)|stomach(1)	9						AGTATGTCTTCAAGCTGCATG	0.323000													11	38					0	0	0.010729	0	0
IRGC	56269	broad.mit.edu	37	19	44223073	44223073	+	Silent	SNP	G	G	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr19:44223073G>A	ENST00000244314.5	+	2	562	c.363G>A	c.(361-363)ccG>ccA	p.P121P		NM_019612.3	NP_062558.1	Q6NXR0	IIGP5_HUMAN	immunity-related GTPase family, cinema	121						membrane	GTP binding|hydrolase activity, acting on acid anhydrides			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|skin(2)	25		Prostate(69;0.0435)				CAGGCTGCCCGGCTGACAAGT	0.657000													7	32					0	0	0.001984	0	0
MID2	11043	broad.mit.edu	37	X	107159287	107159287	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chrX:107159287G>C	ENST00000262843.6	+	6	1677	c.1129G>C	c.(1129-1131)Gat>Cat	p.D377H	MID2_ENST00000443968.2_Missense_Mutation_p.D377H|RP6-191P20.4_ENST00000430140.1_RNA	NM_012216.3|NM_052817.2	NP_036348.2|NP_438112.2	Q9UJV3	TRIM1_HUMAN	midline 2	377	COS.					centrosome|microtubule	ligase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(7)|ovary(1)|prostate(2)	19						CAATTTTAATGATGCCTTTGA	0.353000													33	14					0	0	0.012213	0	0
ANO4	121601	broad.mit.edu	37	12	101491682	101491682	+	Silent	SNP	G	G	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr12:101491682G>T	ENST00000392979.3	+	20	2221	c.1860G>T	c.(1858-1860)gtG>gtT	p.V620V	ANO4_ENST00000392977.3_Silent_p.V655V|ANO4_ENST00000550015.1_Silent_p.V175V|ANO4_ENST00000299222.9_Silent_p.V175V	NM_178826.3	NP_849148.2	Q32M45	ANO4_HUMAN	anoctamin 4	655						chloride channel complex	chloride channel activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						TTATAATGgtgctaaagcaga	0.413000										HNSCC(74;0.22)			25	60					3.1745e-13	3.7586e-13	0.008361	1	0
SORCS3	22986	broad.mit.edu	37	10	106982909	106982909	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr10:106982909G>A	ENST00000369701.3	+	20	2997	c.2770G>A	c.(2770-2772)Gtt>Att	p.V924I	SORCS3_ENST00000369699.4_3'UTR	NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	924						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		AGTTCCATTTGTTGCCATAAG	0.453000													25	73					0	0	0.002780	0	0
MAPKAPK3	7867	broad.mit.edu	37	3	50683618	50683618	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr3:50683618C>T	ENST00000446044.1	+	10	1348	c.752C>T	c.(751-753)tCc>tTc	p.S251F	MAPKAPK3_ENST00000357955.2_Missense_Mutation_p.S251F	NM_001243926.1	NP_001230855.1	Q16644	MAPK3_HUMAN	mitogen-activated protein kinase-activated protein kinase 3	251	Protein kinase.				activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein serine/threonine kinase activity			central_nervous_system(1)|ovary(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.0188)|Kidney(197;0.0223)		CAGGCCATCTCCCCGGGGATG	0.597000													94	58					0	0	0.014410	0	0
AFM	173	broad.mit.edu	37	4	74351714	74351714	+	Silent	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr4:74351714C>T	ENST00000226355.3	+	4	499	c.406C>T	c.(406-408)Ctg>Ttg	p.L136L		NM_001133.2	NP_001124.1	P43652	AFAM_HUMAN	afamin	136	Albumin 1.				vitamin transport		vitamin E binding			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(9)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	32	Breast(15;0.00102)		Epithelial(6;5.69e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|all cancers(17;0.000555)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TGTGGGATTTCTGCCTCCTTT	0.398000													16	39					0	0	0.006122	0	0
KIF5C	3800	broad.mit.edu	37	2	149868101	149868101	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr2:149868101G>A	ENST00000435030.1	+	25	3153	c.2785G>A	c.(2785-2787)Gga>Aga	p.G929R	KIF5C_ENST00000464066.1_3'UTR|KIF5C_ENST00000414838.2_Missense_Mutation_p.G834R|KIF5C_ENST00000397413.1_Missense_Mutation_p.G697R			O60282	KIF5C_HUMAN	kinesin family member 5C	929	Globular.				microtubule-based movement|organelle organization	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(12)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36				BRCA - Breast invasive adenocarcinoma(221;0.108)		CATCCGCCCCGGACACTACCC	0.498000													4	82					0	0	0.000602	0	0
TRPM6	140803	broad.mit.edu	37	9	77386695	77386695	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr9:77386695C>T	ENST00000451710.3	-	25	3697	c.3460G>A	c.(3460-3462)Gtg>Atg	p.V1154M	TRPM6_ENST00000376864.4_Missense_Mutation_p.V1154M|TRPM6_ENST00000449912.2_Missense_Mutation_p.V1149M|TRPM6_ENST00000376872.3_Intron|TRPM6_ENST00000361255.3_Missense_Mutation_p.V1149M|TRPM6_ENST00000360774.1_Missense_Mutation_p.V1154M|TRPM6_ENST00000376871.3_Intron			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	1154					response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						TATTTTTCCACGCACTGCTCC	0.353000													8	45					0	0	0.004482	0	0
ABTB2	25841	broad.mit.edu	37	11	34194744	34194744	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr11:34194744C>T	ENST00000435224.2	-	4	1779	c.1355G>A	c.(1354-1356)cGg>cAg	p.R452Q	ABTB2_ENST00000298992.2_Missense_Mutation_p.R266Q|ABTB2_ENST00000530814.1_5'UTR	NM_145804.2	NP_665803.2	A8K6S9	A8K6S9_HUMAN	ankyrin repeat and BTB (POZ) domain containing 2	266							DNA binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		Acute lymphoblastic leukemia(5;0.0508)|all_hematologic(20;0.0691)				CAGCAGCAGCCGGGCTGCCTG	0.692000													13	36					0	0	0.002450	0	0
KCNH1	3756	broad.mit.edu	37	1	210971026	210971026	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr1:210971026G>A	ENST00000367007.4	-	9	1827	c.1658C>T	c.(1657-1659)cCg>cTg	p.P553L	KCNH1_ENST00000271751.4_Missense_Mutation_p.P580L	NM_002238.3|NM_172362.2	NP_002229.1|NP_758872.1	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 1	580					myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|lung(35)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		CCGGAAGGCCGGGTGCTCCTT	0.607000													22	47					0	0	0.010504	0	0
TRIP13	9319	broad.mit.edu	37	5	908535	908535	+	Silent	SNP	C	C	T	rs146441673		TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr5:908535C>T	ENST00000166345.3	+	9	1181	c.825C>T	c.(823-825)cgC>cgT	p.R275R		NM_004237.3	NP_004228.1	Q15645	PCH2_HUMAN	thyroid hormone receptor interactor 13	275					double-strand break repair|reciprocal meiotic recombination|synaptonemal complex assembly|transcription from RNA polymerase II promoter		ATP binding|identical protein binding|nucleoside-triphosphatase activity|transcription cofactor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)|skin(1)	18			Epithelial(17;0.00147)|OV - Ovarian serous cystadenocarcinoma(19;0.00271)|all cancers(22;0.00622)|Lung(60;0.165)			ATGCCATCCGCGTGGTCAATG	0.522000													22	65					0	0	0.012319	0	0
HIST1H2AL	8332	broad.mit.edu	37	6	27833460	27833460	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr6:27833460C>A	ENST00000357320.2	+	1	427	c.328C>A	c.(328-330)Ccc>Acc	p.P110T		NM_003511.2	NP_003502.1	P0C0S8	H2A1_HUMAN	histone cluster 1, H2al	110					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding			breast(1)|endometrium(1)|large_intestine(2)|lung(3)|urinary_tract(2)	9						TGGTGTCCTGCCCAACATCCA	0.552000													64	98					1.53122e-18	1.84244e-18	0.014410	1	0
EXPH5	23086	broad.mit.edu	37	11	108385369	108385369	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr11:108385369G>C	ENST00000265843.4	-	6	975	c.865C>G	c.(865-867)Cct>Gct	p.P289A	EXPH5_ENST00000428840.1_Missense_Mutation_p.P213A|EXPH5_ENST00000443411.1_Missense_Mutation_p.P101A|EXPH5_ENST00000525344.1_Missense_Mutation_p.P282A|EXPH5_ENST00000524840.1_5'UTR	NM_015065.2	NP_055880.2	Q149M6	Q149M6_HUMAN	exophilin 5	289					intracellular protein transport		Rab GTPase binding	p.P289S(2)		breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(13)|liver(1)|lung(34)|ovary(3)|pancreas(2)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(1)	91		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		CTTGTCCTAGGAGAAAAGGTT	0.378000													12	30					0	0	0.010729	0	0
ELMO3	79767	broad.mit.edu	37	16	67235652	67235652	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr16:67235652G>A	ENST00000393997.2	+	11	1142	c.1085G>A	c.(1084-1086)cGg>cAg	p.R362Q	ELMO3_ENST00000360833.1_Missense_Mutation_p.R345Q|ELMO3_ENST00000477898.1_Missense_Mutation_p.R196Q	NM_024712.3	NP_078988.2	Q96BJ8	ELMO3_HUMAN	engulfment and cell motility 3	309	ELMO.				apoptosis|phagocytosis	cytoplasm|cytoskeleton	SH3 domain binding			cervix(2)|kidney(4)|large_intestine(3)|lung(3)|ovary(2)|prostate(1)|upper_aerodigestive_tract(3)	18		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00067)|Epithelial(162;0.00442)|all cancers(182;0.0417)		CAGGAGCAGCGGGAGCAGCTG	0.637000													17	37					0	0	0.004007	0	0
NBPF9	400818	broad.mit.edu	37	1	144814712	144814712	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr1:144814712G>A	ENST00000440491.2	+	3	350	c.350G>A	c.(349-351)cGa>cAa	p.R117Q	NBPF9_ENST00000281815.8_5'UTR|NBPF9_ENST00000468645.1_3'UTR|NBPF9_ENST00000338347.4_Missense_Mutation_p.R117Q	NM_001037675.2	NP_001032764.1			neuroblastoma breakpoint family, member 9											NS(2)|prostate(1)	3						GCTCAGGAACGAGAGCTGACC	0.507000													87	129					0	0	0.014410	0	0
PHF3	23469	broad.mit.edu	37	6	64422967	64422967	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr6:64422967T>C	ENST00000262043.3	+	16	5823	c.5483T>C	c.(5482-5484)aTg>aCg	p.M1828T	PHF3_ENST00000393387.1_Missense_Mutation_p.M1828T			Q92576	PHF3_HUMAN	PHD finger protein 3	1828	Pro-rich.				multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			breast(7)|cervix(2)|endometrium(8)|kidney(7)|large_intestine(18)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(6)	75	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			CCACAAAGCATGTTTGGATTT	0.512000													91	128					0	0	0.014410	0	0
OR1A2	26189	broad.mit.edu	37	17	3101020	3101020	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr17:3101020G>A	ENST00000381951.1	+	1	208	c.208G>A	c.(208-210)Gac>Aac	p.D70N		NM_012352.1	NP_036484.1	Q9Y585	OR1A2_HUMAN	olfactory receptor, family 1, subfamily A, member 2	70					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|large_intestine(2)|lung(5)|skin(4)|stomach(2)	18						CTCCTTGGTTGACATCATCTT	0.483000													85	112					0	0	0.014410	0	0
GLIS1	148979	broad.mit.edu	37	1	53972293	53972293	+	Silent	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr1:53972293C>T	ENST00000312233.2	-	10	2428	c.1862G>A	c.(1861-1863)tGa>tAa	p.*621*		NM_147193.2	NP_671726.2	Q8NBF1	GLIS1_HUMAN	GLIS family zinc finger 1	0					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(3)|liver(1)|lung(7)|ovary(1)|skin(3)|urinary_tract(4)	24						GGGGCTCCTTCAGGTGTCTGT	0.642000													20	40					0	0	0.007413	0	0
NEU2	4759	broad.mit.edu	37	2	233899356	233899356	+	Silent	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr2:233899356C>T	ENST00000233840.3	+	2	732	c.732C>T	c.(730-732)gtC>gtT	p.V244V		NM_005383.2	NP_005374.2	Q9Y3R4	NEUR2_HUMAN	sialidase 2 (cytosolic sialidase)	244							exo-alpha-sialidase activity			endometrium(3)|large_intestine(2)|lung(10)|skin(2)|urinary_tract(1)	18		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0271)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0839)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000311)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)|GBM - Glioblastoma multiforme(43;0.0488)		GAGCCAGGGTCCAGGCCCAGA	0.652000													18	52					0	0	0.008871	0	0
IWS1	55677	broad.mit.edu	37	2	128255753	128255753	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr2:128255753C>T	ENST00000295321.4	-	6	1787	c.1528G>A	c.(1528-1530)Gat>Aat	p.D510N	IWS1_ENST00000455721.2_Intron|AC010976.2_ENST00000599001.1_RNA	NM_017969.2	NP_060439.2	Q96ST2	IWS1_HUMAN	IWS1 homolog (S. cerevisiae)	510					transcription, DNA-dependent	nucleus	DNA binding			cervix(1)|endometrium(2)|kidney(6)|large_intestine(2)|lung(12)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	28	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0735)		GAATCTGAATCTTCTGCTTCT	0.303000													34	44					0	0	0.003271	0	0
ENPEP	2028	broad.mit.edu	37	4	111397714	111397714	+	Silent	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr4:111397714C>T	ENST00000265162.5	+	1	486	c.144C>T	c.(142-144)gaC>gaT	p.D48D		NM_001977.3	NP_001968.3	Q07075	AMPE_HUMAN	glutamyl aminopeptidase (aminopeptidase A)	48					cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(1)	54		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	CCAGCGGGGACGGCGGGCCGG	0.637000													15	110					0	0	0.002450	0	0
PIK3CA	5290	broad.mit.edu	37	3	178952085	178952085	+	Missense_Mutation	SNP	A	A	G	rs121913279		TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr3:178952085A>G	ENST00000263967.3	+	21	3297	c.3140A>G	c.(3139-3141)cAt>cGt	p.H1047R		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	1047	PI3K/PI4K.		H -> L (in cancer).|H -> R (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; requires binding to p85 regulatory subunit to induce cellular transformation but not interaction with RAS; may mimic the conformatitonal change triggered by the interaction with RAS; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells; increases lipid kinase activity; may alter the interaction of the PI3K/ PI4K kinase domain with the cell membrane).|H -> Y (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.H1047R(1387)|p.H1047L(194)|p.H1047P(1)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AATGATGCACATCATGGTGGC	0.378000	H1047L(EFM19_BREAST)|H1047R(BT20_BREAST)|H1047R(CAL29_URINARY_TRACT)|H1047R(CAL33_UPPER_AERODIGESTIVE_TRACT)|H1047R(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|H1047R(HCC1954_BREAST)|H1047R(HCT116_LARGE_INTESTINE)|H1047R(HSC2_UPPER_AERODIGESTIVE_TRACT)|H1047R(LS180_LARGE_INTESTINE)|H1047R(MCAS_OVARY)|H1047R(MDAMB453_BREAST)|H1047R(NCIH1048_LUNG)|H1047R(RKO_LARGE_INTESTINE)|H1047R(SKOV3_OVARY)|H1047R(T47D_BREAST)	57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			49	24					0	0	0.014410	0	0
ZFHX4	79776	broad.mit.edu	37	8	77618583	77618583	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr8:77618583G>A	ENST00000521891.2	+	2	2708	c.2260G>A	c.(2260-2262)Gga>Aga	p.G754R	ZFHX4_ENST00000517683.1_Intron|ZFHX4_ENST00000518282.1_Missense_Mutation_p.G754R|ZFHX4_ENST00000455469.2_Missense_Mutation_p.G754R|ZFHX4_ENST00000050961.6_Missense_Mutation_p.G754R	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	754						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CAGTGGCTGCGGAACACCCTC	0.527000										HNSCC(33;0.089)			25	19					0	0	0.003330	0	0
KMT2C	58508	broad.mit.edu	37	7	151891214	151891214	+	Splice_Site	SNP	C	C	G			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr7:151891214C>G	ENST00000355193.2	-	31	4759		c.e31-1		KMT2C_ENST00000262189.6_Splice_Site					lysine (K)-specific methyltransferase 2C																		CCGCCAAGCTCTAGGAGATAA	0.418000													10	27					0	0	0.006214	0	0
ASTN1	460	broad.mit.edu	37	1	176833525	176833525	+	Silent	SNP	G	G	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr1:176833525G>A	ENST00000367654.2	-	23	3817	c.3804C>T	c.(3802-3804)ccC>ccT	p.P1268P	ASTN1_ENST00000367657.3_Intron|ASTN1_ENST00000361833.2_Silent_p.P1260P			O14525	ASTN1_HUMAN	astrotactin 1	1268					cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						CAAGTCCGTAGGGTTTGATCT	0.572000													31	83					0	0	0.010818	0	0
FARSB	10056	broad.mit.edu	37	2	223520788	223520788	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr2:223520788G>A	ENST00000281828.6	-	1	268	c.5C>T	c.(4-6)cCg>cTg	p.P2L		NM_005687.3	NP_005678.3	Q9NSD9	SYFB_HUMAN	phenylalanyl-tRNA synthetase, beta subunit	2					phenylalanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|magnesium ion binding|phenylalanine-tRNA ligase activity|RNA binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(5)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	24		Renal(207;0.0183)		Epithelial(121;3.47e-10)|all cancers(144;1.86e-07)|LUSC - Lung squamous cell carcinoma(224;0.00871)|Lung(261;0.011)	L-Phenylalanine(DB00120)	GCTGACAGTCGGCATGGTGTG	0.627000													10	6					0	0	0.010729	0	0
LCT	3938	broad.mit.edu	37	2	136575285	136575285	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr2:136575285C>T	ENST00000264162.2	-	6	1343	c.1333G>A	c.(1333-1335)Ggc>Agc	p.G445S		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	445	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity	p.G445S(1)		breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		GCCCGGAGGCCGCAAAGCAGG	0.642000													33	81					0	0	0.009535	0	0
PACS2	23241	broad.mit.edu	37	14	105849787	105849787	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr14:105849787G>A	ENST00000447393.1	+	16	1892	c.1717G>A	c.(1717-1719)Gag>Aag	p.E573K	PACS2_ENST00000547217.1_Missense_Mutation_p.E539K|PACS2_ENST00000458164.2_Missense_Mutation_p.E573K|PACS2_ENST00000325438.8_Missense_Mutation_p.E569K|PACS2_ENST00000430725.2_Missense_Mutation_p.E494K|PACS2_ENST00000551743.1_Missense_Mutation_p.E83K	NM_015197.3	NP_056012.2	Q86VP3	PACS2_HUMAN	phosphofurin acidic cluster sorting protein 2	569					apoptosis|interspecies interaction between organisms	endoplasmic reticulum lumen|mitochondrion				endometrium(2)|kidney(2)|lung(7)|ovary(3)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	21		all_cancers(154;0.0351)|all_epithelial(191;0.153)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.0145)|Epithelial(46;0.036)	Epithelial(152;0.138)		GCTCTTTGTGGAGCAGCTGTC	0.642000													47	16					0	0	0.014410	0	0
TUBBP5	643224	broad.mit.edu	37	9	141070687	141070687	+	RNA	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr9:141070687C>T	ENST00000503395.1	+	0	1462																											ACAACTGGGCCAAGGGACGCT	0.577000													3	13					0	0	0.009096	0	0
KIAA0195	9772	broad.mit.edu	37	17	73487507	73487507	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr17:73487507C>A	ENST00000314256.7	+	13	1751	c.1357C>A	c.(1357-1359)Cta>Ata	p.L453I	KIAA0195_ENST00000375248.5_Missense_Mutation_p.L463I|KIAA0195_ENST00000579208.1_Missense_Mutation_p.L104I	NM_014738.4	NP_055553.3	Q12767	K0195_HUMAN	KIAA0195	453					ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			breast(2)|endometrium(5)|kidney(2)|large_intestine(7)|lung(17)|ovary(5)|skin(2)|stomach(1)|urinary_tract(1)	42	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			CACCGATGGCCTATCCACCCG	0.637000													37	69					7.63091e-17	9.10786e-17	0.007835	1	0
VPS25	84313	broad.mit.edu	37	17	40925516	40925516	+	Missense_Mutation	SNP	C	C	T	rs141909224		TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr17:40925516C>T	ENST00000253794.2	+	1	63	c.23C>T	c.(22-24)cCg>cTg	p.P8L		NM_032353.2	NP_115729.1	Q9BRG1	VPS25_HUMAN	vacuolar protein sorting 25 homolog (S. cerevisiae)	8					cellular membrane organization|endosome transport|protein transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endosome membrane|nucleoplasm				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)	5		Breast(137;0.00104)		BRCA - Breast invasive adenocarcinoma(366;0.0745)		TTCGAGTGGCCGTGGCAGTAT	0.632000													26	123					0	0	0.004656	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140718650	140718650	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr5:140718650G>C	ENST00000394576.2	+	1	112	c.112G>C	c.(112-114)Gag>Cag	p.E38Q	PCDHGA1_ENST00000517417.1_Intron	NM_018915.2	NP_061738.1														breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(32)|ovary(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTGCGGGAAGAGATCGACAG	0.597000											OREG0016854	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	28	57					0	0	0.006320	0	0
SALL1	6299	broad.mit.edu	37	16	51174768	51174768	+	Silent	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr16:51174768C>T	ENST00000440970.1	-	2	1505	c.1074G>A	c.(1072-1074)gcG>gcA	p.A358A	SALL1_ENST00000251020.4_Silent_p.A455A|SALL1_ENST00000541611.1_Intron|SALL1_ENST00000566102.1_Intron	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	455					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			CAAAGACCTTCGCGCAGAACC	0.512000													47	59					0	0	0.014410	0	0
TAF4	6874	broad.mit.edu	37	20	60584189	60584189	+	Silent	SNP	A	A	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr20:60584189A>T	ENST00000252996.3	-	5	1802	c.1803T>A	c.(1801-1803)tcT>tcA	p.S601S		NM_003185.3	NP_003176.2	O00268	TAF4_HUMAN	TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa	601	TAFH.				interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	37	Breast(26;1e-08)		BRCA - Breast invasive adenocarcinoma(19;3.1e-07)			TTATTAACGTAGATAGGAAAT	0.353000													19	49					0	0	0.006122	0	0
AKT2	208	broad.mit.edu	37	19	40741920	40741920	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr19:40741920T>C	ENST00000392038.2	-	11	1350	c.1052A>G	c.(1051-1053)tAc>tGc	p.Y351C	AKT2_ENST00000311278.6_Missense_Mutation_p.Y308C|AKT2_ENST00000579047.1_Missense_Mutation_p.Y289C|AKT2_ENST00000424901.1_Missense_Mutation_p.Y351C	NM_001243027.1|NM_001243028.1|NM_001626.4	NP_001229956.1|NP_001229957.1|NP_001617.1	P31751	AKT2_HUMAN	v-akt murine thymoma viral oncogene homolog 2	351	Protein kinase.				insulin receptor signaling pathway|negative regulation of plasma membrane long-chain fatty acid transport|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process	cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|cervix(1)|kidney(3)|large_intestine(9)|lung(10)|prostate(2)|skin(1)	27			Lung(22;0.000499)			GTCCTGGTTGTAGAAGGGCAG	0.637000			A		"""ovarian, pancreatic """								12	63					0	0	0.010729	0	0
MAST2	23139	broad.mit.edu	37	1	46383114	46383114	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr1:46383114G>A	ENST00000372008.1	+	2	231	c.64G>A	c.(64-66)Gct>Act	p.A22T	MAST2_ENST00000372009.2_Intron|MAST2_ENST00000361297.2_Intron			Q6P0Q8	MAST2_HUMAN	microtubule associated serine/threonine kinase 2	0					regulation of interleukin-12 biosynthetic process|spermatid differentiation	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|phosphatase binding|protein serine/threonine kinase activity			breast(1)|lung(3)|ovary(5)|stomach(2)	11	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.184)					TGCTGATTGTGCTTTGGCTAC	0.532000													45	48					0	0	0.010771	0	0
TSC22D4	81628	broad.mit.edu	37	7	100075277	100075277	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr7:100075277C>T	ENST00000300181.2	-	2	1139	c.385G>A	c.(385-387)Gag>Aag	p.E129K	TSC22D4_ENST00000393991.1_Intron	NM_030935.3	NP_112197.1	Q9Y3Q8	T22D4_HUMAN	TSC22 domain family, member 4	129					negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding transcription factor activity			breast(2)|kidney(1)|large_intestine(1)|lung(2)|skin(1)|urinary_tract(1)	8	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CTGGCCAGCTCCAACCTGGAA	0.692000													7	6					0	0	0.001984	0	0
SKIDA1	387640	broad.mit.edu	37	10	21804522	21804522	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr10:21804522C>G	ENST00000449193.2	-	4	4482	c.2230G>C	c.(2230-2232)Gaa>Caa	p.E744Q	SKIDA1_ENST00000444772.3_Missense_Mutation_p.E665Q	NM_207371.3	NP_997254.3			SKI/DACH domain containing 1																		GAAGGAGTTTCTTTTTCAGGG	0.453000													80	152					0	0	0.014410	0	0
MLLT3	4300	broad.mit.edu	37	9	20414343	20414343	+	Silent	SNP	A	A	G			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr9:20414343A>G	ENST00000380338.4	-	5	787	c.501T>C	c.(499-501)agT>agC	p.S167S	MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S164S|MLLT3_ENST00000355930.6_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	167	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S167S(19)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctactgctgctgc	0.532000			T	MLL	ALL								4	53					0	0	0.000602	0	0
SAFB	6294	broad.mit.edu	37	19	5641946	5641946	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr19:5641946C>T	ENST00000292123.5	+	4	642	c.535C>T	c.(535-537)Cag>Tag	p.Q179*	SAFB_ENST00000538656.1_Intron|SAFB_ENST00000454510.1_Intron|SAFB_ENST00000433404.1_Nonsense_Mutation_p.Q9*|SAFB_ENST00000592224.1_Nonsense_Mutation_p.Q179*|SAFB_ENST00000588852.1_Nonsense_Mutation_p.Q179*|SAFB_ENST00000586934.1_3'UTR	NM_001201338.1|NM_001201339.1|NM_002967.3	NP_001188267.1|NP_001188268.1|NP_002958.2	Q15424	SAFB1_HUMAN	scaffold attachment factor B	179					chromatin organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	double-stranded DNA binding|nucleotide binding|protein binding|RNA binding			breast(3)|central_nervous_system(1)|endometrium(5)|large_intestine(4)|liver(1)|lung(6)|ovary(2)|skin(1)	23				UCEC - Uterine corpus endometrioid carcinoma (162;0.000222)		GGAGCAGCTTCAGGAACATGC	0.458000													27	27					0	0	0.003954	0	0
SUSD5	26032	broad.mit.edu	37	3	33195134	33195134	+	Silent	SNP	G	G	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr3:33195134G>A	ENST00000309558.3	-	5	1407	c.990C>T	c.(988-990)gtC>gtT	p.V330V		NM_015551.1	NP_056366.1	O60279	SUSD5_HUMAN	sushi domain containing 5	330					cell adhesion	integral to membrane	hyaluronic acid binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24						GTTCACCTGGGACCAATTTTA	0.517000													17	12					0	0	0.006122	0	0
BCAN	63827	broad.mit.edu	37	1	156628471	156628471	+	Silent	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr1:156628471C>T	ENST00000329117.4	+	13	2910	c.2574C>T	c.(2572-2574)tgC>tgT	p.C858C	BCAN_ENST00000496038.1_3'UTR|RP11-284F21.7_ENST00000448869.1_RNA	NM_021948.4	NP_068767.3	Q96GW7	PGCB_HUMAN	brevican	858	Sushi.				cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	55	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TGATCCGATGCCAAGAGAACG	0.632000													32	82					0	0	0.010818	0	0
KIF16B	55614	broad.mit.edu	37	20	16360188	16360188	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr20:16360188T>C	ENST00000354981.2	-	19	2616	c.2459A>G	c.(2458-2460)aAg>aGg	p.K820R	KIF16B_ENST00000355755.3_Missense_Mutation_p.K820R|KIF16B_ENST00000378003.2_Missense_Mutation_p.K46R|KIF16B_ENST00000408042.1_Missense_Mutation_p.K820R	NM_001199865.1|NM_024704.4	NP_001186794.1|NP_078980.3	Q96L93	KI16B_HUMAN	kinesin family member 16B	820	Glu-rich.				cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(24)|ovary(1)|prostate(15)|skin(3)|upper_aerodigestive_tract(2)	74						CAGTTGAGCCTTTTCTAACTC	0.517000													3	87					0	0	0.004672	0	0
HECW2	57520	broad.mit.edu	37	2	197182030	197182030	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr2:197182030C>T	ENST00000260983.2	-	10	2584	c.2402G>A	c.(2401-2403)cGg>cAg	p.R801Q	HECW2_ENST00000409111.1_Missense_Mutation_p.R445Q	NM_020760.1	NP_065811.1	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	801	Interaction with TP73.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(24)|lung(45)|ovary(5)|pancreas(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	113						CCTCTGGTACCGGCTAACATC	0.517000													6	14					0	0	0.001168	0	0
OPA3	80207	broad.mit.edu	37	19	46056884	46056884	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr19:46056884G>A	ENST00000263275.4	-	2	482	c.428C>T	c.(427-429)gCg>gTg	p.A143V	OPA3_ENST00000323060.3_Intron|OPA3_ENST00000544371.1_Missense_Mutation_p.A90V	NM_025136.3	NP_079412.1	Q9H6K4	OPA3_HUMAN	optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)	143					response to stimulus|visual perception	mitochondrion				cervix(1)|large_intestine(1)|lung(2)	4		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00778)|GBM - Glioblastoma multiforme(486;0.0976)|Epithelial(262;0.242)		CTGTGGCGGCGCCGCCTGCAC	0.726000													7	41					0	0	0.001984	0	0
GAB2	9846	broad.mit.edu	37	11	77937653	77937653	+	Silent	SNP	G	G	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr11:77937653G>A	ENST00000361507.4	-	4	1150	c.1065C>T	c.(1063-1065)ccC>ccT	p.P355P	GAB2_ENST00000340149.2_Silent_p.P317P	NM_080491.2	NP_536739.1	Q9UQC2	GAB2_HUMAN	GRB2-associated binding protein 2	355					osteoclast differentiation|phosphatidylinositol-mediated signaling|positive regulation of cell proliferation|positive regulation of mast cell degranulation	cytosol|plasma membrane	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|transmembrane receptor protein tyrosine kinase adaptor activity		INTS4/GAB2(2)	NS(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(8)|ovary(5)|skin(1)|upper_aerodigestive_tract(1)	24	all_cancers(14;3.31e-18)|all_epithelial(13;5.3e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.58e-23)			TTGGCTTGGGGGGGCGGGGTG	0.582000													24	53					0	0	0.004656	0	0
TUBB8P7	197331	broad.mit.edu	37	16	90161902	90161902	+	RNA	SNP	A	A	G	rs6500471	by1000genomes	TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr16:90161902A>G	ENST00000564451.1	+	0	1255				TUBB8P7_ENST00000567960.1_RNA														p.K213R(8)									ATATGTTCCAAGACCCTAAAA	0.537000													4	44					0	0	0.000602	0	0
RRN3P1	730092	broad.mit.edu	37	16	21817457	21817457	+	RNA	SNP	G	G	A	rs150520281	by1000genomes	TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr16:21817457G>A	ENST00000546471.1	-	0	1601																											CTTACATCCAGCTTGAGTAGT	0.259000													5	16					0	0	0.001168	0	0
AJUBA	84962	broad.mit.edu	37	14	23444255	23444255	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr14:23444255T>A	ENST00000262713.2	-	5	1673	c.1298A>T	c.(1297-1299)aAc>aTc	p.N433I	RP11-298I3.5_ENST00000555074.1_Intron|AJUBA_ENST00000397388.3_Missense_Mutation_p.N16I|AJUBA_ENST00000361265.4_Missense_Mutation_p.N433I	NM_032876.4	NP_116265.1	Q96IF1	JUB_HUMAN	ajuba LIM protein	433	LIM zinc-binding 2.				cell cycle|gene silencing by miRNA|positive regulation of protein complex assembly	cell-cell junction|cytoplasmic mRNA processing body|microtubule organizing center	alpha-catenin binding|zinc ion binding										CAGGCACTTGTTGCAAACAAT	0.522000													57	32					0	0	0.014410	0	0
ANKRD20A8P	729171	broad.mit.edu	37	2	95522772	95522772	+	RNA	SNP	T	T	C			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr2:95522772T>C	ENST00000432432.2	-	0	255					NR_040113.1													p.E49G(1)									GCGCTCCACCTCCGCGGCGTC	0.682000													3	105					0	0	0.000602	0	0
EPHA10	284656	broad.mit.edu	37	1	38227344	38227344	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr1:38227344C>T	ENST00000373048.4	-	3	582	c.583G>A	c.(583-585)Gtg>Atg	p.V195M	EPHA10_ENST00000427468.2_Missense_Mutation_p.V195M|EPHA10_ENST00000319637.6_Missense_Mutation_p.V195M	NM_001099439.1	NP_001092909.1	Q5JZY3	EPHAA_HUMAN	EPH receptor A10	195						extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			NS(2)|breast(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(4)|lung(13)|prostate(3)|skin(8)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CATGCGCCCACGTCCTGAAAG	0.682000													18	43					0	0	0.010504	0	0
PDGFRB	5159	broad.mit.edu	37	5	149514571	149514571	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr5:149514571C>T	ENST00000261799.4	-	4	842	c.373G>A	c.(373-375)Gtg>Atg	p.V125M		NM_002609.3	NP_002600.1	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor, beta polypeptide	125					aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(3)|prostate(3)|skin(3)|stomach(6)|urinary_tract(1)	75		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	AGGAAGCCCACGGTGGGATCT	0.522000			T	"""ETV6, TRIP11, HIP1, RAB5EP, H4, NIN, HCMOGT-1, PDE4DIP"""	"""MPD, AML, CMML, CML"""								41	33					0	0	0.006230	0	0
DENND5B	160518	broad.mit.edu	37	12	31586050	31586050	+	Silent	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr12:31586050C>T	ENST00000354285.4	-	9	2390	c.2211G>A	c.(2209-2211)gcG>gcA	p.A737A	DENND5B_ENST00000306833.6_Intron|DENND5B_ENST00000389082.5_Intron|DENND5B_ENST00000536562.1_Intron			Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	0						integral to membrane				NS(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(8)|lung(17)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38						TAGTTCATGGCGCTTGCTGTG	0.428000													32	65					0	0	0.008361	0	0
MALAT1	378938	broad.mit.edu	37	11	65265609	65265609	+	RNA	SNP	G	G	C			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr11:65265609G>C	ENST00000534336.1	+	0	377				AP000769.7_ENST00000602344.1_lincRNA	NR_002819.2																						AGCAGACCCAGAGCAGTGTAA	0.463000													13	38					0	0	0.001855	0	0
MPO	4353	broad.mit.edu	37	17	56352927	56352927	+	Silent	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr17:56352927C>T	ENST00000340482.3	-	7	1613	c.1437G>A	c.(1435-1437)cgG>cgA	p.R479R	MPO_ENST00000225275.3_Silent_p.R447R			P05164	PERM_HUMAN	myeloperoxidase	447					anti-apoptosis|hydrogen peroxide catabolic process|low-density lipoprotein particle remodeling	extracellular space|lysosome|nucleus|stored secretory granule	chromatin binding|heme binding|heparin binding|peroxidase activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(13)|ovary(2)|pancreas(1)|skin(4)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	46					Cefdinir(DB00535)	CCACGATCTTCCGGGCTTCCT	0.607000													14	44					0	0	0.006122	0	0
MPP5	64398	broad.mit.edu	37	14	67779302	67779302	+	Missense_Mutation	SNP	G	G	A	rs150659640		TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr14:67779302G>A	ENST00000261681.4	+	9	1761	c.1100G>A	c.(1099-1101)cGa>cAa	p.R367Q	ATP6V1D_ENST00000553974.1_Intron|MPP5_ENST00000555925.1_Missense_Mutation_p.R333Q	NM_022474.3	NP_071919.2	Q8N3R9	MPP5_HUMAN	membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)	367	SH3.				tight junction assembly	cytoplasm|endomembrane system|tight junction	protein domain specific binding			cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(8)|ovary(1)|skin(1)	18				all cancers(60;0.000388)|OV - Ovarian serous cystadenocarcinoma(108;0.00762)|BRCA - Breast invasive adenocarcinoma(234;0.0106)		GTTCCATGTCGAGAGTTAGGT	0.393000													58	18					0	0	0.014410	0	0
SOBP	55084	broad.mit.edu	37	6	107956339	107956339	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr6:107956339C>T	ENST00000317357.5	+	6	2950	c.2291C>T	c.(2290-2292)gCg>gTg	p.A764V	SOBP_ENST00000494935.1_3'UTR	NM_018013.3	NP_060483.3	A7XYQ1	SOBP_HUMAN	sine oculis binding protein homolog (Drosophila)	764							metal ion binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	26		all_cancers(87;5.26e-06)|Acute lymphoblastic leukemia(125;2.87e-08)|all_hematologic(75;1.14e-06)|all_epithelial(87;0.00193)|Colorectal(196;0.156)		BRCA - Breast invasive adenocarcinoma(108;0.026)|all cancers(137;0.087)|Epithelial(106;0.104)|OV - Ovarian serous cystadenocarcinoma(136;0.154)		GAGGAACCGGCGGTGAGCGAG	0.711000													7	27					0	0	0.001984	0	0
CDC42	998	broad.mit.edu	37	1	22408230	22408230	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr1:22408230G>A	ENST00000344548.3	+	4	372	c.121G>A	c.(121-123)Gca>Aca	p.A41T	CDC42_ENST00000421089.2_Missense_Mutation_p.A83T|CDC42_ENST00000400259.1_Missense_Mutation_p.A41T|CDC42_ENST00000315554.8_Missense_Mutation_p.A41T|CDC42_ENST00000498236.1_3'UTR	NM_001039802.1	NP_001034891.1	P60953	CDC42_HUMAN	cell division cycle 42	41					actin cytoskeleton organization|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|establishment or maintenance of cell polarity|macrophage differentiation|muscle cell differentiation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of protein complex assembly|positive regulation of muscle cell differentiation|positive regulation of pseudopodium assembly|regulation of filopodium assembly|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|filopodium|plasma membrane	GTP binding|GTPase activity|protein binding|thioesterase binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(1)|lung(4)	12		Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;6.55e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)|Prostate(1639;0.0792)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0452)|OV - Ovarian serous cystadenocarcinoma(117;7.32e-26)|Colorectal(126;1.35e-07)|COAD - Colon adenocarcinoma(152;7.73e-06)|GBM - Glioblastoma multiforme(114;8.62e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000649)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(1967;0.00767)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.207)		TGACAACTATGCAGTCACAGT	0.348000													35	63					0	0	0.003271	0	0
PRKAA2	5563	broad.mit.edu	37	1	57161705	57161705	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr1:57161705A>G	ENST00000371244.4	+	6	727	c.661A>G	c.(661-663)Acg>Gcg	p.T221A		NM_006252.3	NP_006243.2	P54646	AAPK2_HUMAN	protein kinase, AMP-activated, alpha 2 catalytic subunit	221	Protein kinase.				carnitine shuttle|cell cycle arrest|cholesterol biosynthetic process|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm	ATP binding|metal ion binding			breast(6)|endometrium(1)|large_intestine(6)|lung(7)|ovary(1)|prostate(1)|stomach(1)	23						GCATGTACCTACGTTATTTAA	0.448000													137	179					0	0	0.014410	0	0
TP63	8626	broad.mit.edu	37	3	189349311	189349311	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr3:189349311T>C	ENST00000264731.3	+	1	96	c.7T>C	c.(7-9)Ttt>Ctt	p.F3L	TP63_ENST00000392460.3_Missense_Mutation_p.F3L|TP63_ENST00000418709.2_Missense_Mutation_p.F3L|TP63_ENST00000440651.2_Missense_Mutation_p.F3L|TP63_ENST00000382063.4_Missense_Mutation_p.F3L|TP63_ENST00000320472.5_Missense_Mutation_p.F3L	NM_001114978.1|NM_003722.4	NP_001108450.1|NP_003713.3	Q9H3D4	P63_HUMAN	tumor protein p63	3	Transcription activation.				anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(5)|large_intestine(12)|lung(15)|ovary(2)|skin(9)|upper_aerodigestive_tract(6)	61	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		GGAAATGAATTTTGAAACTTC	0.378000										HNSCC(45;0.13)			73	70					0	0	0.014410	0	0
LOC220729	220729	broad.mit.edu	37	3	197348646	197348646	+	RNA	SNP	T	T	C	rs138265355	by1000genomes	TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr3:197348646T>C	ENST00000418868.1	-	0	613					NR_003266.2																						TGGGCCTGCCTGCCCTTTCCA	0.532000													6	95					0	0	0.001168	0	0
TP53I11	9537	broad.mit.edu	37	11	44958408	44958408	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr11:44958408C>T	ENST00000533940.1	-	8	884	c.280G>A	c.(280-282)Gga>Aga	p.G94R	TP53I11_ENST00000308212.5_Missense_Mutation_p.G94R|TP53I11_ENST00000531130.2_5'UTR|TP53I11_ENST00000525680.1_Missense_Mutation_p.G94R|TP53I11_ENST00000531928.2_Missense_Mutation_p.G94R|TP53I11_ENST00000395648.3_Missense_Mutation_p.G94R	NM_001258320.1	NP_001245249.1	O14683	P5I11_HUMAN	tumor protein p53 inducible protein 11	94					negative regulation of cell proliferation|response to stress	integral to membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(2)|ovary(1)	5						ACCTGGGCTCCATCAAAGACC	0.687000											OREG0020923	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	26					0	0	0.010729	0	0
PLEKHG4	25894	broad.mit.edu	37	16	67315718	67315718	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr16:67315718A>G	ENST00000360461.5	+	6	3518	c.983A>G	c.(982-984)cAg>cGg	p.Q328R	PLEKHG4_ENST00000427155.2_Missense_Mutation_p.Q328R|PLEKHG4_ENST00000450733.1_Missense_Mutation_p.Q247R|PLEKHG4_ENST00000379344.3_Missense_Mutation_p.Q328R	NM_001129727.1|NM_015432.3	NP_001123199.1|NP_056247.1	Q58EX7	PKHG4_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 4	328					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37				OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)|Kidney(780;0.119)		TACTGCCACCAGGCCTGGCTG	0.617000													4	104					0	0	0.009096	0	0
C1orf43	25912	broad.mit.edu	37	1	154179930	154179930	+	Nonstop_Mutation	SNP	C	C	G			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr1:154179930C>G	ENST00000368521.5	-	7	959	c.761G>C	c.(760-762)tGa>tCa	p.*254S	C1orf43_ENST00000350592.3_Nonstop_Mutation_p.*220S|C1orf43_ENST00000362076.4_Nonstop_Mutation_p.*202S|C1orf43_ENST00000483282.1_5'UTR|C1orf43_ENST00000368519.1_Nonstop_Mutation_p.*236S	NM_001098616.1	NP_001092086.1	Q9BWL3	CA043_HUMAN	chromosome 1 open reading frame 43	0						integral to membrane	coenzyme binding|oxidoreductase activity			cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(3)|ovary(1)	10	all_lung(78;1.98e-30)|Lung NSC(65;2.87e-28)|Hepatocellular(266;0.0877)					TCAGCTCCGTCACAGAGTACT	0.517000													3	159					0	0	0.004672	0	0
ZNF251	90987	broad.mit.edu	37	8	145948537	145948537	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr8:145948537C>T	ENST00000292562.7	-	5	783	c.508G>A	c.(508-510)Gtg>Atg	p.V170M	ZNF251_ENST00000524394.1_Intron	NM_138367.1	NP_612376.1	Q9BRH9	ZN251_HUMAN	zinc finger protein 251	170					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|kidney(1)|large_intestine(5)|lung(9)|stomach(1)	17	all_cancers(97;3.54e-11)|all_epithelial(106;2.65e-10)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.75e-39)|Epithelial(56;7.54e-38)|all cancers(56;6.19e-33)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.11)	GBM - Glioblastoma multiforme(99;0.198)		TCCCTGCCCACGGTAGCTTCT	0.438000													106	133					0	0	0.014410	0	0
FOSL2	2355	broad.mit.edu	37	2	28627022	28627022	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr2:28627022A>G	ENST00000264716.4	+	2	1014	c.151A>G	c.(151-153)Atc>Gtc	p.I51V	FOSL2_ENST00000379619.1_Missense_Mutation_p.I26V|FOSL2_ENST00000460736.1_3'UTR|FOSL2_ENST00000545753.1_Missense_Mutation_p.I12V	NM_005253.3	NP_005244.1	P15408	FOSL2_HUMAN	FOS-like antigen 2	51					cell death|regulation of transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(1)|large_intestine(3)|lung(1)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	14	Acute lymphoblastic leukemia(172;0.155)					CATCCCCACCATCAACGCCAT	0.517000													27	98					0	0	0.005443	0	0
HIST1H2AD	3013	broad.mit.edu	37	6	26199448	26199448	+	Silent	SNP	G	G	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr6:26199448G>A	ENST00000341023.1	-	1	23	c.24C>T	c.(22-24)ggC>ggT	p.G8G	HIST1H3D_ENST00000377831.5_5'UTR	NM_021065.2	NP_066409.1	P20671	H2A1D_HUMAN	histone cluster 1, H2ad	8					nucleosome assembly	nucleosome|nucleus	DNA binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)	6		all_hematologic(11;0.196)				GGGCCTTTCCGCCTTGCTTGC	0.507000													12	29					0	0	0.001855	0	0
RSAD2	91543	broad.mit.edu	37	2	7027109	7027109	+	Silent	SNP	C	C	T	rs111620392	byFrequency	TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr2:7027109C>T	ENST00000382040.3	+	3	688	c.552C>T	c.(550-552)gaC>gaT	p.D184D	RSAD2_ENST00000541728.1_Silent_p.D77D	NM_080657.4	NP_542388.2	Q8WXG1	RSAD2_HUMAN	radical S-adenosyl methionine domain containing 2	184					defense response to virus	endoplasmic reticulum membrane|Golgi apparatus	catalytic activity|iron-sulfur cluster binding|metal ion binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|prostate(1)|skin(1)	20	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			OV - Ovarian serous cystadenocarcinoma(76;0.191)		ACAGCTTTGACGAGGAAGTCA	0.458000													15	37					0	0	0.003163	0	0
CDKN2A	1029	broad.mit.edu	37	9	21971120	21971120	+	Nonsense_Mutation	SNP	G	G	A	rs121913388		TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr9:21971120G>A	ENST00000304494.5	-	2	508	c.238C>T	c.(238-240)Cga>Tga	p.R80*	CDKN2A_ENST00000497750.1_Nonsense_Mutation_p.R29*|CDKN2A_ENST00000578845.2_Nonsense_Mutation_p.R29*|CDKN2A_ENST00000498628.2_Nonsense_Mutation_p.R29*|CDKN2A_ENST00000446177.1_Nonsense_Mutation_p.R80*|CDKN2A_ENST00000498124.1_Nonsense_Mutation_p.R80*|CDKN2A_ENST00000479692.2_Nonsense_Mutation_p.R29*|RP11-145E5.5_ENST00000404796.2_Intron|CDKN2A_ENST00000361570.3_Missense_Mutation_p.P135L|CDKN2A_ENST00000530628.2_Missense_Mutation_p.P94L|CDKN2A_ENST00000494262.1_Nonsense_Mutation_p.R29*|CDKN2A_ENST00000579122.1_Nonsense_Mutation_p.R80*|CDKN2A_ENST00000579755.1_Missense_Mutation_p.P94L	NM_000077.4	NP_000068.1	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A	80			R -> L (in a head and neck tumor).|R -> P (in CMM2; loss of CDK4 binding).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein kinase binding	p.0?(1315)|p.R80*(100)|p.?(44)|p.P135L(7)|p.L65fs*38(1)|p.T79fs*37(1)|p.0(1)|p.A76fs*64(1)|p.T79fs*65(1)|p.E61_L94del(1)|p.A68fs*3(1)|p.R80fs*34(1)		NS(28)|adrenal_gland(6)|autonomic_ganglia(11)|biliary_tract(74)|bone(84)|breast(46)|central_nervous_system(522)|cervix(23)|endometrium(14)|eye(4)|genital_tract(15)|haematopoietic_and_lymphoid_tissue(698)|kidney(39)|large_intestine(11)|liver(92)|lung(365)|meninges(18)|oesophagus(239)|ovary(98)|pancreas(263)|pleura(94)|prostate(13)|salivary_gland(10)|skin(541)|small_intestine(1)|soft_tissue(93)|stomach(48)|thymus(4)|thyroid(24)|upper_aerodigestive_tract(436)|urinary_tract(283)|vulva(2)	4199		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TGCACGGGTCGGGTGAGAGTG	0.726000	R80*(HSC4_UPPER_AERODIGESTIVE_TRACT)|R80*(MEWO_SKIN)	17								HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			17	10					0	0	0.010504	0	0
NEUROG3	50674	broad.mit.edu	37	10	71332754	71332754	+	Missense_Mutation	SNP	C	C	T	rs146974265		TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr10:71332754C>T	ENST00000242462.4	-	2	75	c.46G>A	c.(46-48)Gag>Aag	p.E16K		NM_020999.3	NP_066279.2	Q9Y4Z2	NGN3_HUMAN	neurogenin 3	16					central nervous system development|endocrine pancreas development|peripheral nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity	nucleus	transcription coactivator activity			endometrium(4)|large_intestine(2)|lung(6)|prostate(1)	13						CGCTCCGTCTCACGGGTCACT	0.677000													17	44					0	0	0.004990	0	0
LIMS1	3987	broad.mit.edu	37	2	109292348	109292348	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr2:109292348C>T	ENST00000393310.1	+	6	676	c.509C>T	c.(508-510)gCc>gTc	p.A170V	LIMS1_ENST00000410093.1_Missense_Mutation_p.A174V|LIMS1_ENST00000338045.3_Missense_Mutation_p.A170V|LIMS1_ENST00000544547.1_Missense_Mutation_p.A182V|LIMS1_ENST00000332345.6_Missense_Mutation_p.A170V|LIMS1_ENST00000542845.1_Missense_Mutation_p.A232V|LIMS1_ENST00000409441.1_Missense_Mutation_p.A207V	NM_001193488.1	NP_001180417.1	P48059	LIMS1_HUMAN	LIM and senescent cell antigen-like domains 1	170	LIM zinc-binding 3.				cell aging|cell junction assembly|cellular response to transforming growth factor beta stimulus|negative regulation of transcription, DNA-dependent	cytosol|focal adhesion|perinuclear region of cytoplasm	protein binding|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)	10						GAGCTGACTGCCGATGCACGG	0.527000													4	93					0	0	0.000602	0	0
MTRR	4552	broad.mit.edu	37	5	7870928	7870928	+	Silent	SNP	A	A	G	rs114427781	by1000genomes	TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr5:7870928A>G	ENST00000264668.2	+	2	132	c.102A>G	c.(100-102)ctA>ctG	p.L34L	MTRR_ENST00000341013.6_Silent_p.L7L|MTRR_ENST00000502509.1_Intron|MTRR_ENST00000440940.2_Silent_p.L7L	NM_002454.2|NM_024010.2	NP_002445.2|NP_076915.2	Q9UBK8	MTRR_HUMAN	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	34	Flavodoxin-like.				methionine biosynthetic process	cytosol	[methionine synthase] reductase activity|flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding	p.L34L(1)		NS(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(14)|ovary(1)|prostate(3)|stomach(1)	31					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)|L-Methionine(DB00134)	TTCTGTTACTATATGCTACAC	0.403000													24	30					0	0	0.014323	0	0
MYO15A	51168	broad.mit.edu	37	17	18022714	18022714	+	Silent	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr17:18022714C>T	ENST00000205890.5	+	2	938	c.600C>T	c.(598-600)ggC>ggT	p.G200G		NM_016239.3	NP_057323.3	Q9UKN7	MYO15_HUMAN	myosin XVA	200	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			breast(5)|central_nervous_system(2)|endometrium(17)|kidney(3)|large_intestine(16)|lung(27)|ovary(3)|pancreas(1)|prostate(6)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	99	all_neural(463;0.228)					ACGCGTCAGGCGAGCCCCTGG	0.706000													12	41					0	0	0.010729	0	0
PCDHB4	56131	broad.mit.edu	37	5	140503125	140503125	+	Silent	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr5:140503125C>T	ENST00000194152.1	+	1	1545	c.1545C>T	c.(1543-1545)ctC>ctT	p.L515L		NM_018938.2	NP_061761.1	Q9Y5E5	PCDB4_HUMAN		515	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	67			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGTTCGCCCTCAGGTCGCTGG	0.697000													52	121					0	0	0.014410	0	0
GLRA2	2742	broad.mit.edu	37	X	14748491	14748491	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chrX:14748491G>A	ENST00000218075.4	+	9	1773	c.1243G>A	c.(1243-1245)Gca>Aca	p.A415T	GLRA2_ENST00000355020.4_Missense_Mutation_p.A415T|GLRA2_ENST00000443437.2_Missense_Mutation_p.A326T	NM_002063.3	NP_002054.1	P23416	GLRA2_HUMAN	glycine receptor, alpha 2	415					neuropeptide signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(22)|ovary(1)|prostate(1)|skin(2)	37	Hepatocellular(33;0.128)				Ethanol(DB00898)|Glycine(DB00145)	TGTGGACCGGGCAAAAAGGAT	0.473000													4	78					0	0	0.000602	0	0
RAB9BP1	9366	broad.mit.edu	37	5	104435344	104435344	+	RNA	SNP	C	C	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr5:104435344C>T	ENST00000522464.1	-	0	68				RP11-6N13.1_ENST00000503650.1_lincRNA																							CATTTTGGTACCAAGTAGAAT	0.398000													24	56					0	0	0.014323	0	0
MAP1B	4131	broad.mit.edu	37	5	71494372	71494372	+	Silent	SNP	G	G	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr5:71494372G>A	ENST00000296755.7	+	5	5488	c.5190G>A	c.(5188-5190)ccG>ccA	p.P1730P		NM_005909.3	NP_005900.2	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	1730						microtubule|microtubule associated complex	structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(42)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	104		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		AGGCCTCCCCGTCCACCTCTT	0.483000													84	121					0	0	0.014410	0	0
UNC79	57578	broad.mit.edu	37	14	94088226	94088226	+	Silent	SNP	A	A	G			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr14:94088226A>G	ENST00000553484.1	+	31	4867	c.4713A>G	c.(4711-4713)agA>agG	p.R1571R	UNC79_ENST00000256339.4_Silent_p.R1372R|UNC79_ENST00000393151.2_Silent_p.R1549R|UNC79_ENST00000555664.1_Silent_p.R1549R			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	1549						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						GACGTTCTAGACAGAACTCTG	0.512000													68	33					0	0	0.014410	0	0
GRAMD1C	54762	broad.mit.edu	37	3	113659107	113659107	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr3:113659107C>G	ENST00000358160.4	+	17	2315	c.1823C>G	c.(1822-1824)tCa>tGa	p.S608*	GRAMD1C_ENST00000440446.2_Nonsense_Mutation_p.S403*|GRAMD1C_ENST00000479212.1_3'UTR|GRAMD1C_ENST00000472026.1_Nonsense_Mutation_p.S441*|GRAMD1C_ENST00000452134.2_Nonsense_Mutation_p.S337*	NM_017577.4	NP_060047.3	Q8IYS0	GRM1C_HUMAN	GRAM domain containing 1C	608						integral to membrane				NS(1)|endometrium(1)|large_intestine(6)|lung(13)|ovary(2)|skin(3)	26						GATATGGTGTCAAGAGCAGAA	0.408000													53	169					0	0	0.014410	0	0
HIST2H2BB	338391	broad.mit.edu	37	1	149377834	149377839	+	RNA	DEL	TCTTTG	TCTTTG	-			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr1:149377834_149377839delTCTTTG	ENST00000415338.1	-	0	1061																											GTATCTCTTCTCTTTGTCTTTTTCTG	0.461													3	4	---	---	---	---					
KCNT2	343450	broad.mit.edu	37	1	196311261	196311262	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr1:196311261_196311262insA	ENST00000367433.5	-	15	1601_1602	c.1500_1501insT	c.(1498-1503)ttctgafs	p.*501fs	KCNT2_ENST00000451324.2_Frame_Shift_Ins_p.*112fs|KCNT2_ENST00000294725.8_Frame_Shift_Ins_p.*501fs|KCNT2_ENST00000367431.4_Intron|KCNT2_ENST00000498426.1_5'UTR			Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	501	RCK N-terminal.					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(16)|lung(43)|ovary(5)|pancreas(1)|prostate(1)|skin(11)|stomach(2)|upper_aerodigestive_tract(1)	97						TCATATTCAGCAAAAAATGTAC	0.391													16	34	---	---	---	---					
STK25	10494	broad.mit.edu	37	2	242438109	242438110	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr2:242438109_242438110insA	ENST00000316586.4	-	8	1210_1211	c.861_862insT	c.(859-864)taagcgfs	p.*A287fs	STK25_ENST00000543554.1_Frame_Shift_Ins_p.*A193fs|STK25_ENST00000401869.1_Frame_Shift_Ins_p.*A287fs|STK25_ENST00000405883.3_Frame_Shift_Ins_p.*A210fs|STK25_ENST00000478403.1_5'UTR|STK25_ENST00000405585.1_Frame_Shift_Ins_p.*A210fs|STK25_ENST00000535007.1_Frame_Shift_Ins_p.*A193fs|STK25_ENST00000403346.3_Frame_Shift_Ins_p.*A287fs	NM_001271977.1|NM_001271978.1	NP_001258906.1|NP_001258907.1	O00506	STK25_HUMAN	serine/threonine kinase 25	287					response to oxidative stress|signal transduction	Golgi apparatus	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			breast(1)|kidney(1)|large_intestine(2)|lung(5)|upper_aerodigestive_tract(1)	10		all_cancers(19;2.09e-34)|all_epithelial(40;2.09e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Ovarian(221;0.069)|Lung NSC(271;0.0886)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.2)		Epithelial(32;8.24e-34)|all cancers(36;3.46e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.6e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.1e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0839)		TTCCAGCGCTTATAGCGGTCGA	0.584													27	104	---	---	---	---					
C8orf37-AS1	100616530	broad.mit.edu	37	8	96415908	96415915	+	RNA	DEL	TTTTTTTT	TTTTTTTT	-	rs59279759		TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr8:96415908_96415915delTTTTTTTT	ENST00000521905.1	+	0	126																											aataaaAGACtttttttttttttttttt	0.327													2	4	---	---	---	---					
RP11-34D15.2	0	broad.mit.edu	37	10	102104600	102104601	+	RNA	INS	-	-	T			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr10:102104600_102104601insT	ENST00000429420.1	-	0	103																											AAAAATCACAAttttttttttt	0.401													3	3	---	---	---	---					
GABRA5	2558	broad.mit.edu	37	15	27188544	27188544	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr15:27188544delA	ENST00000335625.5	+	10	1948	c.1060delA	c.(1060-1062)aafs	p.K355fs	GABRA5_ENST00000355395.5_Frame_Shift_Del_p.K355fs|GABRA5_ENST00000400081.3_Frame_Shift_Del_p.K355fs	NM_000810.3	NP_000801.1	P31644	GBRA5_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 5	355					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(26)|ovary(1)|upper_aerodigestive_tract(1)	49		all_lung(180;4.59e-13)|Breast(32;0.000563)|Colorectal(260;0.227)		all cancers(64;1.45e-08)|Epithelial(43;4.96e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0232)|Lung(196;0.182)	Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	CTGGGATGGCAAAAAAGCCTT	0.498													2	4	---	---	---	---					
ZNF587B	100293516	broad.mit.edu	37	19	58352693	58352693	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr19:58352693delA	ENST00000442832.4	+	3	885	c.651delA	c.(649-651)ggfs	p.G217fs	ZNF587B_ENST00000594901.1_Frame_Shift_Del_p.G217fs|CTD-2583A14.10_ENST00000598031.1_Intron|ZNF587B_ENST00000316462.4_Intron	NM_001204818.1	NP_001191747.1	B4DR41	B4DR41_HUMAN	zinc finger protein 587B	217					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding										ATAGCCATGGAGATTCCATGA	0.473													8	20	---	---	---	---					
BCL2L1	598	broad.mit.edu	37	20	30309591	30309591	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CN-6998-01A-23D-2012-08	TCGA-CN-6998-10A-01D-2013-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c364f7e-5b90-44ef-9f80-250e428989ef	87130101-046f-4b71-9ed9-79b2d8556e64	g.chr20:30309591delA	ENST00000307677.4	-	2	841	c.431delT	c.(430-432)tcfs	p.F144fs	BCL2L1_ENST00000420653.1_Frame_Shift_Del_p.F144fs|BCL2L1_ENST00000376062.2_Frame_Shift_Del_p.F144fs|BCL2L1_ENST00000376055.4_Intron	NM_138578.1	NP_612815.1	Q07817	B2CL1_HUMAN	BCL2-like 1	144					induction of apoptosis by intracellular signals|negative regulation of establishment of protein localization in plasma membrane|negative regulation of survival gene product expression|regulation of mitochondrial membrane permeability|regulation of mitochondrial membrane potential|release of cytochrome c from mitochondria|response to cytokine stimulus	integral to membrane|mitochondrial outer membrane|nuclear membrane	BH3 domain binding|identical protein binding			breast(1)|central_nervous_system(1)|large_intestine(2)|lung(4)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11	all_cancers(5;3.47e-06)|all_epithelial(3;1.83e-06)|Lung NSC(7;2.08e-06)|all_lung(7;3.63e-06)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Epithelial(4;2.97e-06)|all cancers(5;3.21e-05)|OV - Ovarian serous cystadenocarcinoma(3;0.00052)|Colorectal(19;0.0055)|COAD - Colon adenocarcinoma(19;0.0264)			GCCGAAGGAGAAAAAGGCCAC	0.542													7	365	---	---	---	---