Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TBC1D10B	26000	broad.mit.edu	37	16	30369853	30369853	+	Silent	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr16:30369853C>T	ENST00000409939.3	-	9	1919	c.1839G>A	c.(1837-1839)gaG>gaA	p.E613E		NM_015527.3	NP_056342.3	Q4KMP7	TB10B_HUMAN	TBC1 domain family, member 10B	613						cytoplasm	Rab GTPase activator activity			endometrium(2)|kidney(1)|lung(2)|urinary_tract(1)	6			Colorectal(24;0.193)			GGGCTGCATTCTCCCGCTCAA	0.637000													6	27					0	0	1	0	0
PCDHGB7	56099	broad.mit.edu	37	5	140797757	140797757	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr5:140797757G>A	ENST00000398594.2	+	1	331	c.331G>A	c.(331-333)Gaa>Aaa	p.E111K	PCDHGA3_ENST00000253812.6_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA10_ENST00000398610.2_Intron	NM_018927.3	NP_061750.1														central_nervous_system(2)|endometrium(9)|kidney(6)|large_intestine(13)|lung(15)|ovary(4)|prostate(3)|stomach(1)|upper_aerodigestive_tract(3)	56			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCTGTGGTGGAAAATCCTTT	0.418000													34	97					0	0	1	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102489170	102489170	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr14:102489170G>C	ENST00000360184.4	+	43	8754	c.8590G>C	c.(8590-8592)Gag>Cag	p.E2864Q		NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	2864					cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						CATCGACAGAGAGAAGGCAAT	0.493000													33	124					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77764690	77764690	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr8:77764690G>C	ENST00000521891.2	+	10	5981	c.5533G>C	c.(5533-5535)Gac>Cac	p.D1845H	ZFHX4_ENST00000455469.2_Missense_Mutation_p.D1800H|ZFHX4_ENST00000050961.6_Missense_Mutation_p.D1800H|ZFHX4_ENST00000518282.1_Missense_Mutation_p.D1819H	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	1800						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AGTGAGTGCAGACTGCCAAAT	0.438000										HNSCC(33;0.089)			9	7					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578402	7578402	+	Silent	SNP	G	G	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr17:7578402G>A	ENST00000420246.2	-	5	660	c.528C>T	c.(526-528)tgC>tgT	p.C176C	TP53_ENST00000455263.2_Silent_p.C176C|TP53_ENST00000445888.2_Silent_p.C176C|TP53_ENST00000269305.4_Silent_p.C176C|TP53_ENST00000574684.1_5'UTR|TP53_ENST00000413465.2_Silent_p.C176C|TP53_ENST00000359597.4_Silent_p.C176C	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	176	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		C -> F (in sporadic cancers; somatic mutation).|C -> G (in sporadic cancers; somatic mutation).|C -> R (in sporadic cancers; somatic mutation).|C -> S (in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> Y (in sporadic cancers; somatic mutation).|CP -> FS (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C176*(12)|p.C176W(11)|p.0?(8)|p.C176_R181delCPHHER(3)|p.R174fs*24(3)|p.H178fs*69(3)|p.R175_E180delRCPHHE(3)|p.C83*(2)|p.V173fs*59(2)|p.C44*(2)|p.R174fs*1(2)|p.V157_C176del20(1)|p.C176F(1)|p.C176fs*65(1)|p.C176_P177delCP(1)|p.V173fs*69(1)|p.C176fs*68(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.R174_H178>S(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.R175_H178>X(1)|p.R42fs*24(1)|p.P177fs*4(1)|p.R174_C176delRRC(1)|p.H168fs*69(1)|p.R174fs*70(1)|p.C176del(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.H178fs*3(1)|p.R174fs*3(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CATGGTGGGGGCAGCGCCTCA	0.647000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			25	31					0	0	1	0	0
RGS22	26166	broad.mit.edu	37	8	101051168	101051168	+	Missense_Mutation	SNP	C	C	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr8:101051168C>A	ENST00000360863.6	-	14	2351	c.2157G>T	c.(2155-2157)aaG>aaT	p.K719N	RGS22_ENST00000523287.1_Missense_Mutation_p.K538N|RGS22_ENST00000523437.1_Missense_Mutation_p.K707N	NM_015668.3	NP_056483.3	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	719					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity		RGS22/SYCP1(2)	breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(33)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	68			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			CTTGCGCTTGCTTGCATACTT	0.393000													3	38					0.004672	0.00479876	1	1	0
RGS4	5999	broad.mit.edu	37	1	163044203	163044203	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr1:163044203C>G	ENST00000421743.2	+	6	922	c.762C>G	c.(760-762)ttC>ttG	p.F254L	RGS4_ENST00000531057.1_Intron|RGS4_ENST00000367908.4_3'UTR|RGS4_ENST00000527809.1_Missense_Mutation_p.F139L|RGS4_ENST00000367906.3_Missense_Mutation_p.F139L|RGS4_ENST00000491263.1_3'UTR|RGS4_ENST00000367909.6_Missense_Mutation_p.F157L	NM_001102445.2|NM_001113380.1	NP_001095915.1|NP_001106851.1	P49798	RGS4_HUMAN	regulator of G-protein signaling 4	157					inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	plasma membrane	calmodulin binding|GTPase activator activity|signal transducer activity			breast(3)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(2)|upper_aerodigestive_tract(2)	21						AGAAGATTTTCAACCTGATGG	0.507000													54	391					0	0	1	0	0
ZNF280A	129025	broad.mit.edu	37	22	22868977	22868977	+	Silent	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr22:22868977C>T	ENST00000302097.3	-	2	1230	c.978G>A	c.(976-978)agG>agA	p.R326R		NM_080740.3	NP_542778.1	P59817	Z280A_HUMAN	zinc finger protein 280A	326					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(4)|lung(8)|ovary(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	18	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		AGCTGTCGTTCCTCTGCTTCT	0.463000													62	127					0	0	1	0	0
WARS	7453	broad.mit.edu	37	14	100801248	100801248	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr14:100801248G>C	ENST00000355338.2	-	11	1998	c.1380C>G	c.(1378-1380)ttC>ttG	p.F460L	WARS_ENST00000344102.5_Missense_Mutation_p.F419L|WARS_ENST00000392882.2_Missense_Mutation_p.F460L|WARS_ENST00000556645.1_Missense_Mutation_p.F419L|RP11-638I2.8_ENST00000557226.1_RNA|WARS_ENST00000358655.4_Missense_Mutation_p.F419L|WARS_ENST00000557135.1_Missense_Mutation_p.F460L	NM_173701.1	NP_776049.1	P23381	SYWC_HUMAN	tryptophanyl-tRNA synthetase	460					angiogenesis|negative regulation of cell proliferation|regulation of angiogenesis|tryptophanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|protein binding|tryptophan-tRNA ligase activity			breast(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)	20		all_cancers(154;0.00223)|all_lung(585;2.48e-06)|all_epithelial(191;0.000564)|Melanoma(154;0.152)			L-Tryptophan(DB00150)	GGGGAGTCATGAACTCTTTCA	0.493000													33	118					0	0	1	0	0
TREML2	79865	broad.mit.edu	37	6	41160555	41160555	+	Silent	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr6:41160555C>T	ENST00000483722.1	-	4	1055	c.870G>A	c.(868-870)aaG>aaA	p.K290K		NM_024807.2	NP_079083.2	Q5T2D2	TRML2_HUMAN	triggering receptor expressed on myeloid cells-like 2	290					T cell activation	cell surface|integral to membrane|plasma membrane	protein binding|receptor activity			breast(1)|central_nervous_system(1)|large_intestine(1)|lung(13)|ovary(1)|prostate(1)	18	Ovarian(28;0.0418)|Colorectal(47;0.196)					TGTGTCTCTTCTTCCAAAACC	0.557000													5	21					0	0	1	0	0
C1orf106	55765	broad.mit.edu	37	1	200867570	200867570	+	Silent	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr1:200867570C>T	ENST00000367342.4	+	2	497	c.297C>T	c.(295-297)atC>atT	p.I99I	C1orf106_ENST00000413687.2_Silent_p.I14I	NM_018265.3	NP_060735.3	Q3KP66	CA106_HUMAN	chromosome 1 open reading frame 106	99										endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(2)	21						ACAGTGGCATCATCCTGCAGT	0.612000													39	119					0	0	1	0	0
NCAPH2	29781	broad.mit.edu	37	22	50955877	50955877	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr22:50955877G>A	ENST00000395701.3	+	3	326	c.232G>A	c.(232-234)Gtc>Atc	p.V78I	NCAPH2_ENST00000395698.3_Missense_Mutation_p.V78I|NCAPH2_ENST00000420993.2_Missense_Mutation_p.V78I|NCAPH2_ENST00000299821.11_Missense_Mutation_p.V78I			Q6IBW4	CNDH2_HUMAN	non-SMC condensin II complex, subunit H2	78					chromosome condensation	chromosome|nucleus				breast(1)|cervix(1)|endometrium(2)|kidney(3)|lung(10)|ovary(1)|prostate(2)|skin(3)|stomach(1)	24		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.212)		CTACTCACTCGTCTACCAGGC	0.607000													37	207					0	0	1	0	0
CIDEA	1149	broad.mit.edu	37	18	12277158	12277158	+	Silent	SNP	G	G	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr18:12277158G>A	ENST00000320477.9	+	5	614	c.549G>A	c.(547-549)gtG>gtA	p.V183V	CIDEA_ENST00000521296.1_3'UTR	NM_001279.3	NP_001270.1	O60543	CIDEA_HUMAN	cell death-inducing DFFA-like effector a	183					DNA damage response, signal transduction resulting in induction of apoptosis|DNA fragmentation involved in apoptotic nuclear change|lipid metabolic process|lipid storage|negative regulation of apoptosis|negative regulation of cytokine secretion|negative regulation of lipid catabolic process|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of sequestering of triglyceride|temperature homeostasis	mitochondrial envelope|nucleus	protein homodimerization activity			central_nervous_system(1)|endometrium(1)|kidney(1)|lung(6)|ovary(1)|pancreas(1)|prostate(2)	13						CCGCCCAGGTGACGGGACAGT	0.577000													32	122					0	0	1	0	0
MMP16	4325	broad.mit.edu	37	8	89339455	89339455	+	Translation_Start_Site	SNP	G	G	C			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr8:89339455G>C	ENST00000286614.6	-	0	262				RP11-586K2.1_ENST00000523254.1_RNA	NM_005941.4	NP_005932.2	P51512	MMP16_HUMAN	matrix metallopeptidase 16 (membrane-inserted)						collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(5)|liver(1)|lung(51)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	81						TGCTTCAATGGATGGACGAGC	0.502000													53	78					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	9858337	9858337	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr16:9858337G>A	ENST00000396573.2	-	14	3373	c.3064C>T	c.(3064-3066)Cgc>Tgc	p.R1022C	GRIN2A_ENST00000404927.2_Missense_Mutation_p.R1022C|GRIN2A_ENST00000562109.1_Missense_Mutation_p.R1022C|GRIN2A_ENST00000330684.3_Missense_Mutation_p.R1022C|GRIN2A_ENST00000535259.1_Missense_Mutation_p.R865C|GRIN2A_ENST00000396575.2_Missense_Mutation_p.R1022C	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	1022					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding	p.R1022C(1)		NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GAATCCTGGCGTATGGAATCC	0.532000													44	100					0	0	1	0	0
ZNF184	7738	broad.mit.edu	37	6	27424635	27424635	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr6:27424635C>G	ENST00000211936.6	-	5	552	c.268G>C	c.(268-270)Gag>Cag	p.E90Q	ZNF184_ENST00000377419.1_Missense_Mutation_p.E90Q	NM_007149.2	NP_009080.2	Q99676	ZN184_HUMAN	zinc finger protein 184	90	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|kidney(9)|large_intestine(13)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	48						ATGCTTGGCTCCATGATCCAT	0.443000													24	53					0	0	1	0	0
CIC	23152	broad.mit.edu	37	19	42791373	42791373	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr19:42791373G>C	ENST00000572681.2	+	4	3228	c.3160G>C	c.(3160-3162)Gag>Cag	p.E1054Q	CIC_ENST00000160740.3_Missense_Mutation_p.E145Q|CIC_ENST00000575354.2_Missense_Mutation_p.E145Q			Q96RK0	CIC_HUMAN	capicua transcriptional repressor	145	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(32)|endometrium(10)|kidney(2)|large_intestine(7)|lung(9)|ovary(7)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	82		Prostate(69;0.00682)				CAGTGAGACAGAGAGTGACCA	0.662000			"""Mis, F, S"""		oligodendroglioma								7	36					0	0	1	0	0
PRKDC	5591	broad.mit.edu	37	8	48855894	48855894	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr8:48855894G>C	ENST00000314191.2	-	10	897	c.841C>G	c.(841-843)Cag>Gag	p.Q281E	PRKDC_ENST00000338368.3_Missense_Mutation_p.Q281E|PRKDC_ENST00000523565.1_5'UTR	NM_006904.6	NP_008835.5	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic polypeptide	281					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				GTGCTAAACTGAGATGCATGC	0.413000								Non-homologous end-joining					3	28					0	0	1	0	0
SLC7A14	57709	broad.mit.edu	37	3	170216564	170216564	+	Silent	SNP	G	G	C			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr3:170216564G>C	ENST00000231706.4	-	4	966	c.651C>G	c.(649-651)ctC>ctG	p.L217L	CLDN11_ENST00000486975.1_Intron|CLDN11_ENST00000451576.1_Intron	NM_020949.2	NP_066000.2	Q8TBB6	S7A14_HUMAN	solute carrier family 7, member 14	217						integral to membrane	amino acid transmembrane transporter activity			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|liver(1)|lung(23)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(4)	53	all_cancers(22;2.41e-22)|all_epithelial(15;4.2e-27)|all_lung(20;1.17e-16)|Lung NSC(18;4.91e-16)|Ovarian(172;0.000902)|Breast(254;0.137)		Lung(28;6.23e-13)|LUSC - Lung squamous cell carcinoma(14;1.48e-12)			TCAGCACATTGAGAACATTGT	0.507000													29	96					0	0	1	0	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274087	39274087	+	Missense_Mutation	SNP	G	G	C	rs141357429	by1000genomes	TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr17:39274087G>C	ENST00000391413.2	-	1	519	c.481C>G	c.(481-483)Ctg>Gtg	p.L161V		NM_033059.3	NP_149048.2	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	161	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].					keratin filament		p.L161V(1)		endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|lung(8)|prostate(5)|skin(1)	33		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			ACTGGACGCAGGcagcagcag	0.657000													7	24					0	0	1	0	0
MEF2C	4208	broad.mit.edu	37	5	88047711	88047711	+	Silent	SNP	A	A	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr5:88047711A>T	ENST00000504921.2	-	5	1224	c.552T>A	c.(550-552)ccT>ccA	p.P184P	MEF2C_ENST00000503554.1_5'UTR|MEF2C_ENST00000506554.1_Silent_p.P184P|MEF2C_ENST00000539796.1_Silent_p.P136P|MEF2C_ENST00000514015.1_Silent_p.P184P|MEF2C_ENST00000514028.1_Silent_p.P184P|MEF2C_ENST00000437473.2_Silent_p.P184P|MEF2C_ENST00000508569.1_Silent_p.P184P|MEF2C_ENST00000510942.1_Silent_p.P184P|MEF2C_ENST00000424173.2_Silent_p.P182P|MEF2C_ENST00000340208.5_Silent_p.P202P			Q06413	MEF2C_HUMAN	myocyte enhancer factor 2C	184					apoptosis|B cell proliferation|innate immune response|learning or memory|muscle cell differentiation|muscle organ development|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|neuron development|positive regulation of muscle cell differentiation|positive regulation of survival gene product expression|positive regulation of transcription from RNA polymerase II promoter|regulation of germinal center formation|regulation of megakaryocyte differentiation|regulation of synaptic activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nuclear speck	activating transcription factor binding|protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(9)|lung(9)|ovary(2)|pancreas(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	40		all_cancers(142;6.67e-05)|all_epithelial(76;7.77e-07)|Lung NSC(167;0.00566)|all_lung(232;0.00732)|Colorectal(57;0.0959)|Ovarian(174;0.1)		OV - Ovarian serous cystadenocarcinoma(54;1.04e-33)|Epithelial(54;1.6e-28)|all cancers(79;2.9e-25)		GTGTTACACCAGGAGACATAC	0.483000										HNSCC(66;0.2)			40	210					0	0	1	0	0
NCOA1	8648	broad.mit.edu	37	2	24927966	24927966	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr2:24927966G>A	ENST00000405141.1	+	13	1672	c.961G>A	c.(961-963)Ggc>Agc	p.G321S	NCOA1_ENST00000288599.5_Missense_Mutation_p.G321S|NCOA1_ENST00000538539.1_Missense_Mutation_p.G321S|NCOA1_ENST00000407230.1_Missense_Mutation_p.G170S|NCOA1_ENST00000406961.1_Missense_Mutation_p.G321S|NCOA1_ENST00000395856.3_Missense_Mutation_p.G321S|NCOA1_ENST00000348332.3_Missense_Mutation_p.G321S			Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1	321									PAX3/NCOA1(8)	breast(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(26)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	53	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GATGACTCGTGGCACTGCCTC	0.423000			T	PAX3	alveolar rhadomyosarcoma								28	77					0	0	1	0	0
ZNF622	90441	broad.mit.edu	37	5	16465250	16465250	+	Silent	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr5:16465250C>T	ENST00000308683.2	-	1	651	c.525G>A	c.(523-525)gaG>gaA	p.E175E		NM_033414.2	NP_219482.1	Q969S3	ZN622_HUMAN	zinc finger protein 622	175						cytoplasm|nucleus	nucleic acid binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|prostate(2)|urinary_tract(1)	25						GGGGTGGTTTCTCACTCGGGT	0.632000													50	135					0	0	1	0	0
WDR1	9948	broad.mit.edu	37	4	10099491	10099491	+	Missense_Mutation	SNP	A	A	C			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr4:10099491A>C	ENST00000382452.2	-	5	684	c.402T>G	c.(400-402)gaT>gaG	p.D134E	WDR1_ENST00000502702.1_Intron|WDR1_ENST00000499869.2_Missense_Mutation_p.D134E|WDR1_ENST00000382451.2_Intron	NM_017491.3	NP_059830.1	O75083	WDR1_HUMAN	WD repeat domain 1	134					platelet activation|platelet degranulation|sensory perception of sound	cytoskeleton|cytosol|extracellular region	actin binding			endometrium(3)|lung(5)|ovary(2)|pancreas(1)|urinary_tract(1)	12				STAD - Stomach adenocarcinoma(129;0.000703)|Colorectal(103;0.0057)|LUSC - Lung squamous cell carcinoma(721;0.0232)		AAGAGCCACTATCCCAGAGGA	0.488000													7	33					0	0	1	0	0
CMA1	1215	broad.mit.edu	37	14	24974771	24974771	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr14:24974771C>T	ENST00000250378.3	-	5	724	c.695G>A	c.(694-696)cGa>cAa	p.R232Q	RP11-80A15.1_ENST00000555109.1_Intron|CMA1_ENST00000206446.4_Missense_Mutation_p.R121Q	NM_001836.3	NP_001827.1	P23946	CMA1_HUMAN	chymase 1, mast cell	232	Peptidase S1.				interleukin-1 beta biosynthetic process|proteolysis	extracellular region	serine-type endopeptidase activity			kidney(1)|lung(8)|pancreas(1)|prostate(1)	11				GBM - Glioblastoma multiforme(265;0.0271)		ATGGGAGATTCGGGTGAAGAC	0.587000													24	140					0	0	1	0	0
NPHS1	4868	broad.mit.edu	37	19	36340175	36340175	+	Missense_Mutation	SNP	C	C	T	rs115308424	by1000genomes	TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr19:36340175C>T	ENST00000378910.5	-	7	802	c.803G>A	c.(802-804)cGa>cAa	p.R268Q	NPHS1_ENST00000353632.6_Missense_Mutation_p.R268Q	NM_004646.3	NP_004637.1	O60500	NPHN_HUMAN	nephrosis 1, congenital, Finnish type (nephrin)	268	Ig-like C2-type 3.				cell adhesion|excretion|muscle organ development	integral to plasma membrane				NS(2)|breast(1)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(1)|lung(26)|ovary(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			ATTACCCCCTCGGGCCACGCA	0.662000													15	42					0	0	1	0	0
SSBP2	23635	broad.mit.edu	37	5	80809449	80809449	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr5:80809449G>A	ENST00000320672.4	-	5	580	c.370C>T	c.(370-372)Cag>Tag	p.Q124*	SSBP2_ENST00000509053.1_Intron|SSBP2_ENST00000514493.1_Intron|SSBP2_ENST00000505980.1_Nonsense_Mutation_p.Q124*|SSBP2_ENST00000515395.1_Intron	NM_001256732.1|NM_001256733.1|NM_012446.3	NP_001243661.1|NP_001243662.1|NP_036578.2	P81877	SSBP2_HUMAN	single-stranded DNA binding protein 2	124	Pro-rich.				regulation of transcription, DNA-dependent	cytoplasm|nucleus	single-stranded DNA binding		SSBP2/JAK2(4)	central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|skin(1)	10		Lung NSC(167;0.00154)|all_lung(232;0.00179)|Ovarian(174;0.0338)		OV - Ovarian serous cystadenocarcinoma(54;1.07e-41)|Epithelial(54;2.79e-35)|all cancers(79;1.18e-29)		CTGAGTACCTGAAAGAACCCT	0.423000													14	99					0	0	1	0	0
TMEM129	92305	broad.mit.edu	37	4	1719932	1719932	+	Silent	SNP	G	G	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr4:1719932G>A	ENST00000382936.3	-	2	1120	c.627C>T	c.(625-627)ctC>ctT	p.L209L	TMEM129_ENST00000536901.1_Silent_p.L209L|TMEM129_ENST00000303277.2_Silent_p.L209L	NM_001127266.1	NP_001120738.1	A0AVI4	TM129_HUMAN	transmembrane protein 129	209						integral to membrane				lung(2)	2			OV - Ovarian serous cystadenocarcinoma(23;0.00765)			GGATGGTGAGGAGCTGCACGG	0.637000													3	12					0	0	1	0	0
MTBP	27085	broad.mit.edu	37	8	121530188	121530188	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr8:121530188G>C	ENST00000305949.1	+	19	2389	c.2344G>C	c.(2344-2346)Gaa>Caa	p.E782Q		NM_022045.3	NP_071328.2	Q96DY7	MTBP_HUMAN	Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa	782	Interaction with MDM2 (By similarity).				cell cycle arrest					NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	30	Lung NSC(37;5.68e-08)|Ovarian(258;0.00769)|all_neural(195;0.0804)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00503)			GCCACAAACAGAACGGTCCTT	0.398000													4	80					0	0	1	0	0
EXD3	54932	broad.mit.edu	37	9	140201526	140201526	+	Missense_Mutation	SNP	C	C	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr9:140201526C>A	ENST00000340951.4	-	22	2702	c.2507G>T	c.(2506-2508)gGa>gTa	p.G836V	EXD3_ENST00000342129.4_Missense_Mutation_p.G474V	NM_017820.3	NP_060290.3	Q8N9H8	MUT7_HUMAN	exonuclease 3'-5' domain containing 3	836					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(2)	12						GAAGACCTTTCCACAGCCCGT	0.697000													10	13					0.000673444	0.000694407	1	1	0
SYT8	90019	broad.mit.edu	37	11	1857283	1857283	+	Silent	SNP	G	G	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr11:1857283G>A	ENST00000535046.1	+	4	882	c.882G>A	c.(880-882)caG>caA	p.Q294Q	SYT8_ENST00000341958.3_Intron|SYT8_ENST00000483280.1_3'UTR|SYT8_ENST00000381968.3_Intron|SYT8_ENST00000436964.2_Silent_p.Q142Q			Q8NBV8	SYT8_HUMAN	synaptotagmin VIII	0	C2 2.					acrosomal vesicle|integral to membrane|plasma membrane|synaptic vesicle	transporter activity			breast(1)|large_intestine(1)|lung(2)|ovary(1)|skin(1)	6		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		GGGAAGGGCAGACCCCATGCC	0.687000													3	18					0	0	1	0	0
CSRP2BP	57325	broad.mit.edu	37	20	18143304	18143304	+	Silent	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr20:18143304C>T	ENST00000278816.2	+	7	2036	c.1386C>T	c.(1384-1386)ccC>ccT	p.P462P	CSRP2BP_ENST00000435364.2_Silent_p.P462P|CSRP2BP_ENST00000377681.2_Silent_p.P461P|CSRP2BP_ENST00000489634.2_Silent_p.P334P			Q9H8E8	CSR2B_HUMAN	CSRP2 binding protein	462					histone H3 acetylation	Ada2/Gcn5/Ada3 transcription activator complex|cytoplasm	LIM domain binding|N-acetyltransferase activity			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(12)|ovary(2)|prostate(3)|skin(1)|stomach(1)	34						GGTATACTCCCGTGAGCATCT	0.512000													15	87					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70331687	70331687	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr11:70331687C>T	ENST00000338508.4	-	32	4713	c.4714G>A	c.(4714-4716)Gat>Aat	p.D1572N	SHANK2_ENST00000409161.1_Missense_Mutation_p.D975N|SHANK2_ENST00000423696.2_Missense_Mutation_p.D1192N|SHANK2_ENST00000449833.2_Missense_Mutation_p.D976N			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	1192					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			CTATCTACATCTTCTTCCACG	0.547000													133	1114					0	0	1	0	0
LPHN3	23284	broad.mit.edu	37	4	62453119	62453119	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr4:62453119G>A	ENST00000512091.1	+	4	977	c.230G>A	c.(229-231)cGa>cAa	p.R77Q	LPHN3_ENST00000506746.1_Missense_Mutation_p.R145Q|LPHN3_ENST00000506720.1_Missense_Mutation_p.R145Q|LPHN3_ENST00000509896.1_Missense_Mutation_p.R145Q|LPHN3_ENST00000504896.1_Missense_Mutation_p.R77Q|LPHN3_ENST00000508946.1_Missense_Mutation_p.R77Q|LPHN3_ENST00000514157.1_Missense_Mutation_p.R77Q|LPHN3_ENST00000545650.1_Missense_Mutation_p.R77Q|LPHN3_ENST00000514591.1_Missense_Mutation_p.R77Q|LPHN3_ENST00000508693.1_Missense_Mutation_p.R145Q|LPHN3_ENST00000507164.1_Missense_Mutation_p.R145Q|LPHN3_ENST00000506700.1_Missense_Mutation_p.R77Q|LPHN3_ENST00000514996.1_Missense_Mutation_p.R77Q|LPHN3_ENST00000511324.1_Missense_Mutation_p.R145Q|LPHN3_ENST00000507625.1_Missense_Mutation_p.R145Q			Q9HAR2	LPHN3_HUMAN	latrophilin 3	77	SUEL-type lectin.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(21)|lung(73)|ovary(1)|pancreas(1)|prostate(6)|upper_aerodigestive_tract(1)	125						GAGAATATCCGATGTTATCTG	0.398000													7	23					0	0	1	0	0
MADD	8567	broad.mit.edu	37	11	47311465	47311465	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr11:47311465G>A	ENST00000342922.4	+	17	3161	c.2804G>A	c.(2803-2805)gGc>gAc	p.G935D	MADD_ENST00000407859.3_Missense_Mutation_p.G912D|MADD_ENST00000406482.1_Missense_Mutation_p.G892D|MADD_ENST00000395344.3_Missense_Mutation_p.G892D|MADD_ENST00000349238.3_Missense_Mutation_p.G955D|MADD_ENST00000311027.5_Missense_Mutation_p.G955D|MADD_ENST00000402799.1_Missense_Mutation_p.G892D|MADD_ENST00000402192.2_Missense_Mutation_p.G935D|MADD_ENST00000395336.3_Missense_Mutation_p.G955D	NM_130470.2	NP_569826.2	Q8WXG6	MADD_HUMAN	MAP-kinase activating death domain	955					activation of MAPK activity|apoptosis|cell surface receptor linked signaling pathway|regulation of apoptosis|regulation of cell cycle	cytoplasm|integral to membrane|plasma membrane	death receptor binding|protein kinase activator activity|Rab guanyl-nucleotide exchange factor activity			breast(7)|central_nervous_system(2)|endometrium(9)|kidney(3)|large_intestine(19)|lung(26)|ovary(6)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	84				Lung(87;0.182)		GTGCTGGACGGCCAGGGAGTT	0.597000													8	39					0	0	1	0	0
ITFG3	83986	broad.mit.edu	37	16	312193	312193	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr16:312193G>C	ENST00000399932.3	+	7	1261	c.810G>C	c.(808-810)agG>agC	p.R270S	ITFG3_ENST00000450082.2_Missense_Mutation_p.R270S|ITFG3_ENST00000600536.1_Missense_Mutation_p.R270S|ITFG3_ENST00000301679.2_Missense_Mutation_p.R270S|ITFG3_ENST00000301678.3_Missense_Mutation_p.R270S|ITFG3_ENST00000442458.2_Missense_Mutation_p.R270S			Q9H0X4	ITFG3_HUMAN	integrin alpha FG-GAP repeat containing 3	270						integral to membrane				central_nervous_system(3)|endometrium(2)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	16		all_cancers(16;0.000129)|all_epithelial(16;0.000206)|Hepatocellular(16;0.00264)|Lung NSC(18;0.0626)|all_lung(18;0.13)				ACGTCACCAGGACAGGTGCCC	0.617000													14	36					0	0	1	0	0
ANKRD20A8P	729171	broad.mit.edu	37	2	95522815	95522815	+	RNA	SNP	A	A	G			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr2:95522815A>G	ENST00000432432.2	-	0	212					NR_040113.1																						ATCTTCTGCAATTCGGAGTCC	0.652000													5	117					0	0	1	0	0
ERBB2	2064	broad.mit.edu	37	17	37868215	37868215	+	Silent	SNP	C	C	G			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr17:37868215C>G	ENST00000406381.2	+	10	1356	c.846C>G	c.(844-846)acC>acG	p.T282T	ERBB2_ENST00000541774.1_Silent_p.T297T|ERBB2_ENST00000540147.1_Silent_p.T282T|ERBB2_ENST00000445658.2_Silent_p.T36T|ERBB2_ENST00000269571.5_Silent_p.T312T|ERBB2_ENST00000578199.1_Silent_p.T282T|ERBB2_ENST00000540042.1_Silent_p.T282T|ERBB2_ENST00000584601.1_Silent_p.T282T|ERBB2_ENST00000584450.1_Silent_p.T312T	NM_001005862.1	NP_001005862.1	P04626	ERBB2_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2	312					cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			NS(1)|breast(16)|central_nervous_system(17)|endometrium(6)|haematopoietic_and_lymphoid_tissue(8)|kidney(4)|large_intestine(16)|liver(3)|lung(125)|ovary(18)|pancreas(1)|prostate(4)|skin(1)|stomach(14)|upper_aerodigestive_tract(9)|urinary_tract(4)	247	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	GATCCTGCACCCTCGTCTGCC	0.572000		1	"""A, Mis, O"""		"""breast, ovarian, other tumour types, NSCLC, gastric"""					TCGA GBM(5;<1E-08)			36	230					0	0	1	0	0
EYA1	2138	broad.mit.edu	37	8	72129059	72129059	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr8:72129059G>C	ENST00000340726.3	-	14	1867	c.1228C>G	c.(1228-1230)Cct>Gct	p.P410A	EYA1_ENST00000388743.2_Missense_Mutation_p.P409A|EYA1_ENST00000419131.1_Missense_Mutation_p.P375A|EYA1_ENST00000303824.7_Missense_Mutation_p.P404A|EYA1_ENST00000388742.4_Missense_Mutation_p.P410A|EYA1_ENST00000388741.2_Missense_Mutation_p.P376A|EYA1_ENST00000388740.3_Missense_Mutation_p.P377A	NM_000503.4	NP_000494.2	Q99502	EYA1_HUMAN	eyes absent homolog 1 (Drosophila)	410					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			NS(2)|breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(15)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	44	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			GCTGCAGCAGGAAAGCCATCT	0.433000													5	113					0	0	1	0	0
ADCY8	114	broad.mit.edu	37	8	131922087	131922087	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr8:131922087C>G	ENST00000286355.5	-	6	3599	c.1507G>C	c.(1507-1509)Gat>Cat	p.D503H	ADCY8_ENST00000377928.3_Missense_Mutation_p.D503H	NM_001115.2	NP_001106.1	P40145	ADCY8_HUMAN	adenylate cyclase 8 (brain)	503					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(21)|lung(67)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(5)|urinary_tract(2)	134	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			ATGTCAACATCGTGTTTTGTC	0.478000										HNSCC(32;0.087)			22	118					0	0	1	0	0
MYO7B	4648	broad.mit.edu	37	2	128351213	128351213	+	Silent	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr2:128351213C>T	ENST00000389524.4	+	18	2291	c.2238C>T	c.(2236-2238)ttC>ttT	p.F746F	MYO7B_ENST00000409816.2_Silent_p.F746F|MYO7B_ENST00000428314.1_Silent_p.F746F			Q6PIF6	MYO7B_HUMAN	myosin VIIB	746	IQ 1.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(46)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	75	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		CAAAAATTTTCCTGAGGGTGA	0.607000													16	109					0	0	1	0	0
CRYBB1	1414	broad.mit.edu	37	22	26995607	26995607	+	Silent	SNP	G	G	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr22:26995607G>A	ENST00000215939.2	-	6	736	c.606C>T	c.(604-606)cgC>cgT	p.R202R		NM_001887.3	NP_001878.1	P53674	CRBB1_HUMAN	crystallin, beta B1	202	Beta/gamma crystallin 'Greek key' 4.				visual perception		structural constituent of eye lens			breast(1)|endometrium(4)|large_intestine(8)|lung(8)|ovary(1)|prostate(3)|skin(2)|urinary_tract(4)	31						ACTGGTACCCGCGGTAGCCAG	0.597000													18	50					0	0	1	0	0
PCDH1	5097	broad.mit.edu	37	5	141244793	141244793	+	Missense_Mutation	SNP	C	C	T	rs142395032		TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr5:141244793C>T	ENST00000287008.3	-	3	1250	c.1103G>A	c.(1102-1104)aGt>aAt	p.S368N	PCDH1_ENST00000394536.3_Missense_Mutation_p.S368N|PCDH1_ENST00000536585.1_Missense_Mutation_p.S346N|PCDH1_ENST00000456271.1_Missense_Mutation_p.S356N|PCDH1_ENST00000511044.1_5'UTR|PCDH1_ENST00000503492.1_Intron	NM_032420.2	NP_115796.2	Q08174	PCDH1_HUMAN	protocadherin 1	368	Cadherin 3.				cell-cell signaling|homophilic cell adhesion|nervous system development	cell-cell junction|integral to plasma membrane	calcium ion binding			breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(4)|lung(20)|ovary(5)|skin(3)|upper_aerodigestive_tract(1)	51		Lung NSC(810;0.027)|all_lung(500;0.0321)|all_hematologic(541;0.0433)|Prostate(461;0.0453)|Breast(839;0.128)|Lung SC(612;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;1.06e-05)		GGCACGGGCACTCTTGGGGTT	0.572000													32	85					0	0	1	0	0
LRRFIP1	9208	broad.mit.edu	37	2	238672203	238672203	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr2:238672203G>A	ENST00000244815.5	+	10	2015	c.1775G>A	c.(1774-1776)aGa>aAa	p.R592K	LRRFIP1_ENST00000392000.4_Missense_Mutation_p.R616K|LRRFIP1_ENST00000308482.9_Intron|LRRFIP1_ENST00000289175.6_Missense_Mutation_p.R560K	NM_004735.3	NP_004726.2	Q32MZ4	LRRF1_HUMAN	leucine rich repeat (in FLII) interacting protein 1	616	Lys-rich.				negative regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|cytoskeleton|nucleus	DNA binding|double-stranded RNA binding|protein binding			NS(1)|breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)	29		Breast(86;0.00257)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;9.75e-23)|OV - Ovarian serous cystadenocarcinoma(60;1.01e-10)|Kidney(56;4.85e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.31e-07)|BRCA - Breast invasive adenocarcinoma(100;0.000151)|Lung(119;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0325)|COAD - Colon adenocarcinoma(134;0.228)		TCTACTGACAGAAAGTCAGCA	0.383000													5	22					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105410637	105410637	+	Silent	SNP	G	G	C			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr14:105410637G>C	ENST00000333244.5	-	7	11270	c.11151C>G	c.(11149-11151)ctC>ctG	p.L3717L	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3717						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GGTGCTCTTTGAGGCCGGCTC	0.627000													166	297					0	0	1	0	0
CYP2D7	1564	broad.mit.edu	37	22	42538870	42538870	+	RNA	SNP	A	A	C	rs2982057	by1000genomes	TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr22:42538870A>C	ENST00000358097.4	-	0	449				CYP2D7P1_ENST00000433992.1_RNA|CYP2D7P1_ENST00000424775.1_RNA																endometrium(1)	1						CCATAGCGCGACAGGAACACC	0.687000													6	53					0	0	1	0	0
ADAMTS3	9508	broad.mit.edu	37	4	73161471	73161471	+	Missense_Mutation	SNP	T	T	C			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr4:73161471T>C	ENST00000286657.4	-	19	2659	c.2623A>G	c.(2623-2625)Aaa>Gaa	p.K875E		NM_014243.2	NP_055058.2	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 3	875	TSP type-1 2.				collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(33)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	76			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TTATCACTTTTCCTACGGCAT	0.373000													9	57					0	0	1	0	0
COL24A1	255631	broad.mit.edu	37	1	86591642	86591642	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr1:86591642C>G	ENST00000370571.2	-	3	743	c.377G>C	c.(376-378)aGa>aCa	p.R126T	COL24A1_ENST00000436319.1_Missense_Mutation_p.R126T	NM_152890.5	NP_690850.2	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1	126	TSP N-terminal.				cell adhesion	collagen	extracellular matrix structural constituent			NS(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(9)|liver(1)|lung(56)|ovary(4)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	101				all cancers(265;0.0627)|Epithelial(280;0.0689)		ATTTTTATTTCTAATGCTGAA	0.368000													15	39					0	0	1	0	0
RDH11	51109	broad.mit.edu	37	14	68151846	68151846	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr14:68151846C>G	ENST00000381346.4	-	6	850	c.740G>C	c.(739-741)aGa>aCa	p.R247T	RDH11_ENST00000553384.1_Missense_Mutation_p.R234T|RP11-1012A1.4_ENST00000554493.1_5'UTR|RDH11_ENST00000428130.2_Missense_Mutation_p.R177T|RP11-1012A1.4_ENST00000553306.1_Missense_Mutation_p.D78H	NM_001252650.1|NM_016026.3	NP_001239579.1|NP_057110.3	Q8TC12	RDH11_HUMAN	retinol dehydrogenase 11 (all-trans/9-cis/11-cis)	247					retinol metabolic process|steroid metabolic process	endoplasmic reticulum membrane|integral to membrane	binding|NADP-retinol dehydrogenase activity|retinol dehydrogenase activity			breast(2)|endometrium(1)|kidney(3)|large_intestine(2)|lung(3)|ovary(1)	12				all cancers(60;0.00047)|OV - Ovarian serous cystadenocarcinoma(108;0.00206)|BRCA - Breast invasive adenocarcinoma(234;0.00924)	Vitamin A(DB00162)	CCACATCCATCTCATGAAAGA	0.512000													9	75					0	0	1	0	0
NBEA	26960	broad.mit.edu	37	13	36229032	36229032	+	Silent	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr13:36229032C>T	ENST00000400445.3	+	53	8547	c.8013C>T	c.(8011-8013)ctC>ctT	p.L2671L	NBEA_ENST00000379939.2_Silent_p.L2668L|NBEA_ENST00000540320.1_Silent_p.L2671L|NBEA_ENST00000310336.4_Silent_p.L2671L|NBEA_ENST00000379922.3_Silent_p.L249L|NBEA_ENST00000537702.1_Silent_p.L464L	NM_015678.4	NP_056493.3	Q8NFP9	NBEA_HUMAN	neurobeachin	2671						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		TCACAGACCTCGTTGACCAGA	0.368000													4	16					0	0	1	0	0
GDNF	2668	broad.mit.edu	37	5	37815895	37815895	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr5:37815895C>G	ENST00000326524.2	-	3	693	c.494G>C	c.(493-495)aGa>aCa	p.R165T	GDNF_ENST00000344622.4_Missense_Mutation_p.R139T|GDNF_ENST00000381826.4_Missense_Mutation_p.R156T|GDNF_ENST00000427982.1_Missense_Mutation_p.R182T|GDNF_ENST00000515058.1_Missense_Mutation_p.R139T	NM_000514.3	NP_000505.1	P39905	GDNF_HUMAN	glial cell derived neurotrophic factor	165					adult locomotory behavior|anti-apoptosis|axon guidance|branching involved in ureteric bud morphogenesis|enteric nervous system development|mRNA stabilization|negative regulation of neuron apoptosis|neural crest cell migration|peristalsis|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of dopamine secretion|positive regulation of monooxygenase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of ureteric bud formation|postganglionic parasympathetic nervous system development|regulation of dopamine uptake|signal transduction|sympathetic nervous system development	extracellular region	growth factor activity|protein homodimerization activity			NS(1)|endometrium(1)|large_intestine(2)|liver(1)|lung(8)|skin(2)	15	all_lung(31;0.00118)					CCTTCTATTTCTGGATAAGTT	0.448000													21	112					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237841360	237841360	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr1:237841360G>A	ENST00000366574.2	+	61	9160	c.8843G>A	c.(8842-8844)aGa>aAa	p.R2948K	RYR2_ENST00000360064.6_Missense_Mutation_p.R2946K|RYR2_ENST00000542537.1_Missense_Mutation_p.R2932K	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	2948	Modulator (Potential).				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GGTGGCAGCAGAGGCAAAGGA	0.348000													3	10					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48311578	48311578	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr7:48311578C>G	ENST00000435803.1	+	17	2339	c.2315C>G	c.(2314-2316)tCt>tGt	p.S772C		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	772					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						AATATAAGTTCTCTGTGGACA	0.383000													3	26					0	0	1	0	0
PRB1	5542	broad.mit.edu	37	12	11506284	11506284	+	Silent	SNP	A	A	C			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr12:11506284A>C	ENST00000500254.2	-	4	391	c.354T>G	c.(352-354)ccT>ccG	p.P118P	PRB1_ENST00000546254.1_Silent_p.P118P|PRB1_ENST00000545626.1_Intron	NM_005039.3|NM_199353.2	NP_005030.2|NP_955385.1	P04280	PRP1_HUMAN	proline-rich protein BstNI subfamily 1	312	15 X 20 AA approximate tandem repeats of P-P-G-K-P-Q-G-P-P-[PAQ]-Q-[GE]-[GD]- [NKS]-[KSQRN]-[PRQS]-[QS] [GPS]-[PQAR]- [PSR].		Missing (in allele M).|Missing (in clone CP-4).|Missing (in clone CP-5).			extracellular region				NS(1)|central_nervous_system(1)|kidney(4)|large_intestine(1)|lung(9)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	20			OV - Ovarian serous cystadenocarcinoma(49;0.185)			GGGGACCTTGAGGTTTGTTGC	0.617000													30	247					0	0	1	0	0
MFSD8	256471	broad.mit.edu	37	4	128865003	128865003	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr4:128865003C>T	ENST00000296468.3	-	5	470	c.343G>A	c.(343-345)Gtg>Atg	p.V115M	MFSD8_ENST00000513559.1_Missense_Mutation_p.V70M|MFSD8_ENST00000541133.1_Missense_Mutation_p.V70M|MFSD8_ENST00000515130.1_5'UTR	NM_152778.2	NP_689991.1	Q8NHS3	MFSD8_HUMAN	major facilitator superfamily domain containing 8	115					cell death|transmembrane transport	integral to membrane|lysosomal membrane				cervix(2)|endometrium(1)|large_intestine(4)|liver(1)|lung(11)|ovary(1)|prostate(2)|skin(1)	23						TTGGCTGCCACGGAAATCAAG	0.413000													17	88					0	0	1	0	0
EPHA2	1969	broad.mit.edu	37	1	16456789	16456789	+	Silent	SNP	G	G	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr1:16456789G>A	ENST00000358432.5	-	15	2755	c.2601C>T	c.(2599-2601)atC>atT	p.I867I		NM_004431.3	NP_004422.2	P29317	EPHA2_HUMAN	EPH receptor A2	867	Mediates interaction with ARHGEF16 and ELMO2.|Protein kinase.				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding	p.I867I(1)		NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	42		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	GGATGCTGACGATGTCAGCGA	0.622000													14	66					0	0	1	0	0
THBS2	7058	broad.mit.edu	37	6	169623544	169623544	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr6:169623544C>G	ENST00000366787.3	-	19	3049	c.2800G>C	c.(2800-2802)Gat>Cat	p.D934H	XXyac-YX65C7_A.2_ENST00000444188.1_RNA	NM_003247.2	NP_003238.2	P35442	TSP2_HUMAN	thrombospondin 2	934					cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			NS(3)|biliary_tract(1)|endometrium(8)|kidney(3)|large_intestine(23)|liver(1)|lung(56)|ovary(6)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	111		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		TCAAAATCATCTTTACAAATA	0.413000													22	73					0	0	1	0	0
SLC13A1	6561	broad.mit.edu	37	7	122757637	122757637	+	Missense_Mutation	SNP	A	A	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr7:122757637A>T	ENST00000194130.2	-	14	1577	c.1538T>A	c.(1537-1539)cTt>cAt	p.L513H	SLC13A1_ENST00000539873.1_3'UTR	NM_022444.3	NP_071889.2	Q9BZW2	S13A1_HUMAN	solute carrier family 13 (sodium/sulfate symporter), member 1	513						integral to membrane|plasma membrane	sodium:sulfate symporter activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(20)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	45					Succinic acid(DB00139)	CAGAATATAAAGAGGGTTCAC	0.348000													4	47					0	0	1	0	0
ZMIZ1	57178	broad.mit.edu	37	10	81072505	81072505	+	Silent	SNP	G	G	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr10:81072505G>A	ENST00000334512.5	+	25	3775	c.3203G>A	c.(3202-3204)tGa>tAa	p.*1068*	ZMIZ1_ENST00000446377.2_Silent_p.*134*	NM_020338.3	NP_065071.1	Q9ULJ6	ZMIZ1_HUMAN	zinc finger, MIZ-type containing 1	0					transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(2)|prostate(3)|skin(1)	30	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			GAGAACAACTGAGGGCCACCC	0.597000													48	109					0	0	1	0	0
SPTLC1	10558	broad.mit.edu	37	9	94794750	94794750	+	Silent	SNP	G	G	C			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr9:94794750G>C	ENST00000262554.2	-	15	1424	c.1419C>G	c.(1417-1419)ctC>ctG	p.L473L		NM_006415.2	NP_006406.1	O15269	SPTC1_HUMAN	serine palmitoyltransferase, long chain base subunit 1	473						integral to membrane|SPOTS complex	protein binding|pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			breast(2)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|skin(1)|urinary_tract(1)	14					L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	ACTCTGCCTAGAGCAGGACGG	0.582000													10	66					0	0	1	0	0
ANKMY1	51281	broad.mit.edu	37	2	241494435	241494435	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr2:241494435C>T	ENST00000401804.1	-	3	322	c.184G>A	c.(184-186)Gct>Act	p.A62T	ANKMY1_ENST00000403283.1_Missense_Mutation_p.A141T|ANKMY1_ENST00000373320.4_5'UTR|ANKMY1_ENST00000405523.3_Missense_Mutation_p.A62T|ANKMY1_ENST00000361678.4_Missense_Mutation_p.A62T|ANKMY1_ENST00000391987.1_5'UTR|ANKMY1_ENST00000406958.1_Missense_Mutation_p.A62T|ANKMY1_ENST00000405002.1_5'UTR|ANKMY1_ENST00000536462.1_Missense_Mutation_p.A15T|ANKMY1_ENST00000272972.3_5'UTR|ANKMY1_ENST00000373318.2_Missense_Mutation_p.A62T|ANKMY1_ENST00000462004.1_5'UTR			Q9P2S6	ANKY1_HUMAN	ankyrin repeat and MYND domain containing 1	0							zinc ion binding			central_nervous_system(1)|endometrium(5)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	30		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.03e-30)|all cancers(36;4.78e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.45e-14)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.8e-06)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.01)|Colorectal(34;0.0101)|COAD - Colon adenocarcinoma(134;0.0476)		GGGCCCTCAGCTTCCTCCTCT	0.592000													34	91					0	0	1	0	0
ANKRD20A8P	729171	broad.mit.edu	37	2	95522786	95522786	+	RNA	SNP	T	T	C			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr2:95522786T>C	ENST00000432432.2	-	0	241					NR_040113.1													p.K44K(1)									CGGCGTCGCCTTTGACAGCTG	0.687000													5	109					0	0	1	0	0
PLCB2	5330	broad.mit.edu	37	15	40588791	40588791	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr15:40588791C>T	ENST00000260402.3	-	15	1780	c.1531G>A	c.(1531-1533)Gaa>Aaa	p.E511K	PLCB2_ENST00000456256.2_Missense_Mutation_p.E511K|PLCB2_ENST00000557821.1_Missense_Mutation_p.E507K	NM_004573.2	NP_004564.2	Q00722	PLCB2_HUMAN	phospholipase C, beta 2	511	Glu-rich.				activation of phospholipase C activity|intracellular signal transduction|lipid catabolic process|phospholipid metabolic process|synaptic transmission	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(4)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(3)	39		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.38e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0508)		tcttcctcttccacctcctcc	0.597000													5	34					0	0	1	0	0
TACC2	10579	broad.mit.edu	37	10	123970124	123970124	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr10:123970124C>T	ENST00000369005.1	+	9	6524	c.6184C>T	c.(6184-6186)Cag>Tag	p.Q2062*	TACC2_ENST00000453444.2_Nonsense_Mutation_p.Q2066*|TACC2_ENST00000369000.1_5'UTR|TACC2_ENST00000368999.1_Nonsense_Mutation_p.Q140*|TACC2_ENST00000358010.1_Nonsense_Mutation_p.Q208*|TACC2_ENST00000369001.1_5'UTR|TACC2_ENST00000513429.1_Nonsense_Mutation_p.Q208*|TACC2_ENST00000515273.1_Nonsense_Mutation_p.Q2066*|TACC2_ENST00000369004.3_Nonsense_Mutation_p.Q140*|TACC2_ENST00000515603.1_Nonsense_Mutation_p.Q2017*|TACC2_ENST00000260733.3_Nonsense_Mutation_p.Q140*|TACC2_ENST00000360561.3_Nonsense_Mutation_p.Q140*|TACC2_ENST00000334433.3_Nonsense_Mutation_p.Q2062*	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	2062						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				CGCTAAGAATCAGGAGGGCAA	0.532000													25	68					0	0	1	0	0
SYT11	23208	broad.mit.edu	37	1	155837784	155837784	+	Silent	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr1:155837784C>T	ENST00000368324.4	+	2	316	c.63C>T	c.(61-63)atC>atT	p.I21I	SYT11_ENST00000539162.1_Intron	NM_152280.4	NP_689493.3	Q9BT88	SYT11_HUMAN	synaptotagmin XI	21						cell junction|synaptic vesicle membrane	protein binding|transporter activity			breast(2)|central_nervous_system(1)|endometrium(1)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;0.000162)			CCGGCCTCATCGGGGCCTCTG	0.582000													7	57					0	0	1	0	0
CCDC138	165055	broad.mit.edu	37	2	109489982	109489982	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr2:109489982C>T	ENST00000295124.4	+	14	1829	c.1769C>T	c.(1768-1770)cCt>cTt	p.P590L	CCDC138_ENST00000412964.2_Intron	NM_144978.1	NP_659415.1	Q96M89	CC138_HUMAN	coiled-coil domain containing 138	590										endometrium(1)|large_intestine(3)|lung(7)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	14						CTTCGAGCCCCTAAGCTTGAT	0.338000													6	42					0	0	1	0	0
HSPA1L	3305	broad.mit.edu	37	6	31779372	31779372	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr6:31779372C>G	ENST00000375654.4	-	2	567	c.378G>C	c.(376-378)ttG>ttC	p.L126F	HSPA1L_ENST00000417199.3_Missense_Mutation_p.L126F	NM_005527.3	NP_005518.3	P34931	HS71L_HUMAN	heat shock 70kDa protein 1-like	126					response to unfolded protein		ATP binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(10)|ovary(3)|pleura(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	34						TCAACTTAGTCAATACCATCG	0.463000													8	46					0	0	1	0	0
GOLGA6L3	100133220	broad.mit.edu	37	15	83014132	83014132	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr15:83014132C>G	ENST00000557886.1	-	6	550	c.451G>C	c.(451-453)Gag>Cag	p.E151Q															p.E151Q(4)		endometrium(6)|kidney(5)|prostate(1)	12						GCTGGGGGCTCTGGGGCCAGG	0.522000													3	9					0	0	1	0	0
OR2M3	127062	broad.mit.edu	37	1	248367272	248367272	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr1:248367272C>G	ENST00000456743.1	+	1	941	c.903C>G	c.(901-903)ttC>ttG	p.F301L		NM_001004689.1	NP_001004689.1	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M, member 3	301					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|large_intestine(4)|lung(33)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	50	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CCAGAGCATTCATGAAGATCT	0.428000													36	93					0	0	1	0	0
SIM1	6492	broad.mit.edu	37	6	100911253	100911253	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr6:100911253G>A	ENST00000369208.3	-	2	874	c.92C>T	c.(91-93)tCg>tTg	p.S31L	SIM1_ENST00000262901.4_Missense_Mutation_p.S31L			P81133	SIM1_HUMAN	single-minded family bHLH transcription factor 1	31	Helix-loop-helix motif.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity	p.S31L(1)		breast(1)|central_nervous_system(4)|endometrium(5)|kidney(1)|large_intestine(15)|lung(34)|ovary(4)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(5)	79		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		GGTGATAGCCGAGGGCAAAGG	0.458000													16	83					0	0	1	0	0
TGM4	7047	broad.mit.edu	37	3	44938204	44938204	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr3:44938204G>C	ENST00000296125.4	+	6	621	c.553G>C	c.(553-555)Gag>Cag	p.E185Q		NM_003241.3	NP_003232.2	P49221	TGM4_HUMAN	transglutaminase 4	185					peptide cross-linking|protein polyamination		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			NS(1)|breast(1)|endometrium(2)|large_intestine(9)|lung(21)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)	38				BRCA - Breast invasive adenocarcinoma(193;0.00963)|KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0686)	L-Glutamine(DB00130)	AAAATAGTTTGAGAAAAATGT	0.493000													14	36					0	0	1	0	0
ITGA8	8516	broad.mit.edu	37	10	15689001	15689001	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr10:15689001C>T	ENST00000378076.3	-	12	1404	c.1051G>A	c.(1051-1053)Gag>Aag	p.E351K		NM_003638.1	NP_003629.1	P53708	ITA8_HUMAN	integrin, alpha 8	351					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						GGGTTGCTCTCAAATTCACGT	0.507000													28	45					0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82837879	82837879	+	Silent	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr5:82837879C>T	ENST00000265077.3	+	8	9622	c.9057C>T	c.(9055-9057)atC>atT	p.I3019I	VCAN-AS1_ENST00000512090.1_RNA|VCAN_ENST00000342785.4_Intron|VCAN_ENST00000512590.2_Intron|VCAN_ENST00000513016.1_3'UTR|VCAN_ENST00000343200.5_Silent_p.I2032I|VCAN_ENST00000502527.2_Intron|VCAN-AS1_ENST00000513899.1_RNA	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	3019	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		CAGCTTTAATCAGAGGGCAGG	0.473000													30	57					0	0	1	0	0
ZKSCAN4	387032	broad.mit.edu	37	6	28212905	28212905	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr6:28212905G>C	ENST00000377294.2	-	5	1870	c.1627C>G	c.(1627-1629)Ctt>Gtt	p.L543V	ZKSCAN4_ENST00000423974.2_Missense_Mutation_p.L388V	NM_019110.3	NP_061983.2	Q969J2	ZKSC4_HUMAN	zinc finger with KRAB and SCAN domains 4	543					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|large_intestine(2)|lung(10)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	18						CACTGTGAAAGAGTTTTTTTC	0.443000													32	90					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77764944	77764944	+	Silent	SNP	G	G	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr8:77764944G>A	ENST00000521891.2	+	10	6235	c.5787G>A	c.(5785-5787)caG>caA	p.Q1929Q	ZFHX4_ENST00000455469.2_Silent_p.Q1884Q|ZFHX4_ENST00000050961.6_Silent_p.Q1884Q|ZFHX4_ENST00000518282.1_Silent_p.Q1903Q	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	1884						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AAAACAGGCAGAAGGTACAGA	0.413000										HNSCC(33;0.089)			29	41					0	0	1	0	0
LPPR2	64748	broad.mit.edu	37	19	11474442	11474442	+	Silent	SNP	C	C	G			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr19:11474442C>G	ENST00000251473.5	+	8	1270	c.894C>G	c.(892-894)ctC>ctG	p.L298L	DKFZP761J1410_ENST00000591608.1_Silent_p.L273L	NM_001170635.1|NM_022737.2	NP_001164106.1|NP_073574.2																					GCCGAAGGCTCTCTCCCTGGG	0.632000													8	53					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179477226	179477226	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr2:179477226C>G	ENST00000589042.1	-	266	50250	c.50026G>C	c.(50026-50028)Gag>Cag	p.E16676Q	TTN_ENST00000591111.1_Missense_Mutation_p.E15035Q|TTN_ENST00000359218.5_Missense_Mutation_p.E7736Q|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E7803Q|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E7611Q|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.E14108Q|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000589234.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	15035	Fibronectin type-III 21.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCATCTTTCTCAGGAACTGTC	0.448000													6	27					0	0	1	0	0
ANKRD20A8P	729171	broad.mit.edu	37	2	95515045	95515045	+	RNA	SNP	T	T	C			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr2:95515045T>C	ENST00000432432.2	-	0	612					NR_040113.1																						AAGTGGGGTATTACTGTCCTA	0.333000													21	151					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168099105	168099105	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr2:168099105C>G	ENST00000409195.1	+	9	1292	c.1203C>G	c.(1201-1203)ttC>ttG	p.F401L	XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409273.1_Missense_Mutation_p.F179L|XIRP2_ENST00000295237.9_Missense_Mutation_p.F401L|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409756.2_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	226					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						AAGAGACTTTCAAGCCATCAT	0.423000													11	89					0	0	1	0	0
LEPREL1	55214	broad.mit.edu	37	3	189688630	189688630	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr3:189688630G>A	ENST00000319332.5	-	13	2065	c.1868C>T	c.(1867-1869)aCa>aTa	p.T623I	LEPREL1_ENST00000427335.2_Missense_Mutation_p.T442I	NM_018192.3	NP_060662.2	Q8IVL5	P3H2_HUMAN	leprecan-like 1	623	Fe2OG dioxygenase.				collagen metabolic process|negative regulation of cell proliferation|peptidyl-proline hydroxylation	basement membrane|endoplasmic reticulum|Golgi apparatus	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(10)|liver(1)|lung(8)|ovary(2)|prostate(2)|skin(5)	41	all_cancers(143;4.01e-10)|Ovarian(172;0.0925)		Lung(62;4.35e-05)	GBM - Glioblastoma multiforme(93;0.02)	L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	ATCCATCTCTGTGAATATGAA	0.313000													12	41					0	0	1	0	0
BBS9	27241	broad.mit.edu	37	7	33407426	33407426	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr7:33407426C>T	ENST00000242067.6	+	17	2262	c.1741C>T	c.(1741-1743)Cac>Tac	p.H581Y	BBS9_ENST00000396127.2_Missense_Mutation_p.H546Y|BBS9_ENST00000355070.2_Missense_Mutation_p.H576Y|BBS9_ENST00000354265.4_Missense_Mutation_p.H546Y|BBS9_ENST00000350941.3_Missense_Mutation_p.H541Y	NM_198428.2	NP_940820.1	Q3SYG4	PTHB1_HUMAN	Bardet-Biedl syndrome 9	581					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding		BBS9/PKD1L1(2)	NS(1)|autonomic_ganglia(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	50			GBM - Glioblastoma multiforme(11;0.0894)			AATGGGTTTTCACTTCTTAGG	0.358000									Bardet-Biedl syndrome				5	70					0	0	1	0	0
LRRC36	55282	broad.mit.edu	37	16	67400972	67400972	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr16:67400972G>A	ENST00000329956.6	+	8	826	c.807G>A	c.(805-807)atG>atA	p.M269I	LRRC36_ENST00000541146.1_Intron|LRRC36_ENST00000290940.7_Start_Codon_SNP_p.M1I|LRRC36_ENST00000435835.3_Missense_Mutation_p.M148I|LRRC36_ENST00000563189.1_Missense_Mutation_p.M148I	NM_018296.5	NP_060766.5	Q1X8D7	LRC36_HUMAN	leucine rich repeat containing 36	269										endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	24		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0669)|Epithelial(162;0.161)		CAGAGAAGATGACTAGAGAAG	0.403000													15	88					0	0	1	0	0
NRCAM	4897	broad.mit.edu	37	7	107875086	107875086	+	Silent	SNP	A	A	G			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr7:107875086A>G	ENST00000379028.3	-	6	641	c.171T>C	c.(169-171)atT>atC	p.I57I	NRCAM_ENST00000413765.2_Silent_p.I57I|NRCAM_ENST00000379022.4_Silent_p.I57I|NRCAM_ENST00000379024.4_Silent_p.I57I|NRCAM_ENST00000351718.4_Silent_p.I51I|NRCAM_ENST00000425651.2_Silent_p.I57I			Q92823	NRCAM_HUMAN	neuronal cell adhesion molecule	57	Ig-like 1.				angiogenesis|axon guidance|axonal fasciculation|cell-cell adhesion|central nervous system development|clustering of voltage-gated sodium channels|neuron migration|positive regulation of neuron differentiation|regulation of axon extension|synapse assembly	external side of plasma membrane|integral to plasma membrane	ankyrin binding			breast(4)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(8)|liver(1)|lung(36)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	65						GAGGGTCAATAATGTAATCTT	0.353000													10	66					0	0	1	0	0
CAPZB	832	broad.mit.edu	37	1	19705096	19705096	+	Silent	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr1:19705096C>T	ENST00000264203.3	-	5	838	c.345G>A	c.(343-345)ccG>ccA	p.P115P	CAPZB_ENST00000375144.1_Silent_p.P77P|CAPZB_ENST00000375142.1_Silent_p.P89P|CAPZB_ENST00000482808.1_5'UTR|CAPZB_ENST00000433834.1_Silent_p.P118P|CAPZB_ENST00000264202.6_Silent_p.P89P|CAPZB_ENST00000401084.2_Silent_p.P89P			P47756	CAPZB_HUMAN	capping protein (actin filament) muscle Z-line, beta	89					actin cytoskeleton organization|actin filament capping|blood coagulation|cellular component movement	cytosol|F-actin capping protein complex|WASH complex	actin binding			endometrium(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)|urinary_tract(1)	7		Colorectal(325;3.93e-05)|Renal(390;0.000147)|all_lung(284;0.000169)|Lung NSC(340;0.000202)|Breast(348;0.000496)|Ovarian(437;0.00428)|Myeloproliferative disorder(586;0.0262)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Kidney(64;8.63e-06)|BRCA - Breast invasive adenocarcinoma(304;4.06e-05)|KIRC - Kidney renal clear cell carcinoma(64;0.000175)|GBM - Glioblastoma multiforme(114;0.000525)|STAD - Stomach adenocarcinoma(196;0.00779)|READ - Rectum adenocarcinoma(331;0.103)|Lung(427;0.173)		GCCGAGCTGACGGCATGGCCC	0.502000													15	70					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139207509	139207509	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr8:139207509C>T	ENST00000395297.1	-	9	1035	c.865G>A	c.(865-867)Gag>Aag	p.E289K		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	289										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			ACCTGTAGCTCTGAGCACAGC	0.433000										HNSCC(54;0.14)			8	76					0	0	1	0	0
OR5H6	79295	broad.mit.edu	37	3	97983171	97983171	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr3:97983171G>A	ENST00000383696.2	+	1	84	c.43G>A	c.(43-45)Gag>Aag	p.E15K	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005479.1	NP_001005479.1	Q8NGV6	OR5H6_HUMAN	olfactory receptor, family 5, subfamily H, member 6 (gene/pseudogene)	15					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(2)|endometrium(1)|large_intestine(4)|lung(20)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	34						GACATGCAGTGAGGAGATGGA	0.383000													23	101					0	0	1	0	0
GALNTL5	168391	broad.mit.edu	37	7	151716859	151716859	+	Missense_Mutation	SNP	G	G	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr7:151716859G>T	ENST00000392800.2	+	9	1559	c.1305G>T	c.(1303-1305)gaG>gaT	p.E435D	GALNTL5_ENST00000431418.2_Missense_Mutation_p.E435D	NM_145292.3	NP_660335.2	Q7Z4T8	GLTL5_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 5	435						Golgi membrane|integral to membrane	transferase activity, transferring glycosyl groups			NS(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(11)|ovary(2)|prostate(2)|skin(3)	32	all_neural(206;0.187)	all_hematologic(28;0.0749)	OV - Ovarian serous cystadenocarcinoma(82;0.00427)	UCEC - Uterine corpus endometrioid carcinoma (81;0.18)|BRCA - Breast invasive adenocarcinoma(188;0.166)		TCTTCCCAGAGTTGGAGGCAT	0.403000													20	37					4.96729e-08	5.24435e-08	1	1	0
CHRM5	1133	broad.mit.edu	37	15	34356456	34356456	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr15:34356456G>A	ENST00000383263.5	+	3	2208	c.1538G>A	c.(1537-1539)cGa>cAa	p.R513Q	CHRM5_ENST00000557872.1_Missense_Mutation_p.R513Q	NM_012125.3	NP_036257.1	P08912	ACM5_HUMAN	cholinergic receptor, muscarinic 5	513					cell proliferation|inhibition of adenylate cyclase activity by muscarinic acetylcholine receptor signaling pathway	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(10)|ovary(1)|skin(1)	20		all_lung(180;1.76e-08)		all cancers(64;4.82e-17)|GBM - Glioblastoma multiforme(113;2.58e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0262)	Atropine(DB00572)|Benzquinamide(DB00767)|Cryptenamine(DB00785)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Thiethylperazine(DB00372)	CTTCTCTGCCGATGGAAAAAG	0.463000													9	50					0	0	1	0	0
SRCAP	10847	broad.mit.edu	37	16	30748954	30748954	+	Silent	SNP	A	A	C			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr16:30748954A>C	ENST00000262518.4	+	34	7978	c.7593A>C	c.(7591-7593)ccA>ccC	p.P2531P	SRCAP_ENST00000344771.4_Silent_p.P2373P|SRCAP_ENST00000395059.2_Silent_p.P2469P	NM_006662.2	NP_006653.2	Q6ZRS2	SRCAP_HUMAN	Snf2-related CREBBP activator protein	2531	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			TGCTTGGTCCACCTTCTGTGC	0.597000													12	112					0	0	1	0	0
RFFL	117584	broad.mit.edu	37	17	33339032	33339032	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr17:33339032G>C	ENST00000315249.7	-	7	1269	c.1047C>G	c.(1045-1047)atC>atG	p.I349M	RFFL_ENST00000447669.2_Missense_Mutation_p.I349M|RFFL_ENST00000413582.2_Missense_Mutation_p.I341M|RFFL_ENST00000394597.2_Missense_Mutation_p.I349M|RFFL_ENST00000268850.7_Missense_Mutation_p.I313M|RFFL_ENST00000584655.1_Missense_Mutation_p.I313M|RFFL_ENST00000378516.2_Missense_Mutation_p.I341M|RAD51L3-RFFL_ENST00000593039.1_Missense_Mutation_p.I258M|RFFL_ENST00000415395.2_Missense_Mutation_p.I349M			Q8WZ73	RFFL_HUMAN	ring finger and FYVE-like domain containing E3 ubiquitin protein ligase	349					apoptosis	membrane	ligase activity|zinc ion binding			kidney(1)|large_intestine(2)|lung(3)	6		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)		ACTGCCGGCAGATGGGACATT	0.522000													13	83					0	0	1	0	0
UBBP4	23666	broad.mit.edu	37	17	21730916	21730916	+	Missense_Mutation	SNP	G	G	T	rs111245273	by1000genomes	TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr17:21730916G>T	ENST00000584755.1	+	2	615	c.218G>T	c.(217-219)cGg>cTg	p.R73L	UBBP4_ENST00000584398.1_Intron|UBBP4_ENST00000578713.1_Missense_Mutation_p.R73L|UBBP4_ENST00000583708.1_Intron														p.R73L(24)		endometrium(9)|kidney(4)|lung(4)|prostate(3)|urinary_tract(4)	24						GTCCTGCGTCGGAGAGGTGGT	0.552000													4	89					0.150653	0.150653	1	1	0
AMACR	23600	broad.mit.edu	37	5	34004719	34004719	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr5:34004719C>T	ENST00000335606.6	-	3	600	c.512G>A	c.(511-513)cGc>cAc	p.R171H	AMACR_ENST00000382085.3_Missense_Mutation_p.R171H|AMACR_ENST00000382072.2_Intron|AMACR_ENST00000502637.1_Missense_Mutation_p.R171H|AMACR_ENST00000441713.2_Intron|AMACR_ENST00000514195.1_Intron	NM_001167595.1|NM_014324.5	NP_001161067.1|NP_055139.4	Q9UHK6	AMACR_HUMAN	alpha-methylacyl-CoA racemase	171					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	mitochondrion|peroxisomal matrix	alpha-methylacyl-CoA racemase activity			endometrium(3)|kidney(1)|large_intestine(4)|lung(9)|stomach(1)|urinary_tract(1)	19						AGTGCGTGTGCGGTCAAAAAG	0.478000													4	125					0	0	1	0	0
PKN3	29941	broad.mit.edu	37	9	131469624	131469624	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr9:131469624G>C	ENST00000291906.4	+	6	1168	c.775G>C	c.(775-777)Gct>Cct	p.A259P		NM_013355.3	NP_037487.2	Q6P5Z2	PKN3_HUMAN	protein kinase N3	259					signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm	ATP binding|protein binding|protein kinase C activity			breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|pancreas(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	24						AGAGTTGCGGGCTGCGGTGCC	0.612000													14	23					0	0	1	0	0
SKI	6497	broad.mit.edu	37	1	2160602	2160602	+	Missense_Mutation	SNP	G	G	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr1:2160602G>T	ENST00000378536.4	+	1	469	c.397G>T	c.(397-399)Gac>Tac	p.D133Y		NM_003036.3	NP_003027.1	P12755	SKI_HUMAN	v-ski avian sarcoma viral oncogene homolog	133					anterior/posterior axis specification|BMP signaling pathway|bone morphogenesis|cell motility|cell proliferation|embryonic limb morphogenesis|face morphogenesis|lens morphogenesis in camera-type eye|myelination in peripheral nervous system|myotube differentiation|negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of fibroblast proliferation|negative regulation of osteoblast differentiation|negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|neural tube closure|nose morphogenesis|olfactory bulb development|palate development|positive regulation of DNA binding|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|protein homotrimerization|regulation of apoptosis|retina development in camera-type eye|skeletal muscle fiber development|SMAD protein signal transduction|somatic stem cell maintenance|transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|PML body|transcription factor complex|transcriptional repressor complex	histone deacetylase inhibitor activity|nucleotide binding|protein domain specific binding|protein kinase binding|repressing transcription factor binding|SMAD binding|transcription corepressor activity|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)|kidney(2)|lung(5)|prostate(1)|stomach(1)	10	all_cancers(77;0.000139)|all_epithelial(69;4.45e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)			Epithelial(90;2.14e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.72e-29)|GBM - Glioblastoma multiforme(42;2.45e-08)|Colorectal(212;5.33e-05)|COAD - Colon adenocarcinoma(227;0.000228)|Kidney(185;0.00268)|BRCA - Breast invasive adenocarcinoma(365;0.00471)|STAD - Stomach adenocarcinoma(132;0.0147)|KIRC - Kidney renal clear cell carcinoma(229;0.0385)|Lung(427;0.207)		GGTGCTGCGCGACTTCTCGCT	0.622000													5	27					0.014758	0.014927	1	1	0
SLK	9748	broad.mit.edu	37	10	105781404	105781404	+	Silent	SNP	G	G	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr10:105781404G>A	ENST00000369755.3	+	18	4019	c.3474G>A	c.(3472-3474)gaG>gaA	p.E1158E	SLK_ENST00000335753.4_Silent_p.E1127E	NM_014720.2	NP_055535.2	Q9H2G2	SLK_HUMAN	STE20-like kinase	1158					apoptosis|nucleotide-excision repair	cytoplasm|plasma membrane	ATP binding|DNA binding|nuclease activity|protein serine/threonine kinase activity			kidney(1)|lung(1)|ovary(2)|skin(2)|stomach(2)	8		Colorectal(252;0.178)		Epithelial(162;5.81e-10)|all cancers(201;2.35e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		TGTTGGTTGAGCATGAGACTC	0.323000													4	53					0	0	1	0	0
ZNF613	79898	broad.mit.edu	37	19	52448568	52448568	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr19:52448568C>G	ENST00000293471.6	+	6	2111	c.1432C>G	c.(1432-1434)Cac>Gac	p.H478D	ZNF613_ENST00000601794.1_3'UTR|ZNF613_ENST00000391794.4_Missense_Mutation_p.H442D	NM_001031721.3	NP_001026891.2	Q6PF04	ZN613_HUMAN	zinc finger protein 613	478					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|skin(1)|urinary_tract(1)	19		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.0183)		CCAGAGAATTCACACAGGAGA	0.448000													23	49					0	0	1	0	0
CCR8	1237	broad.mit.edu	37	3	39374086	39374086	+	Silent	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr3:39374086C>T	ENST00000326306.4	+	2	402	c.264C>T	c.(262-264)ttC>ttT	p.F88F	CCR8_ENST00000414803.1_Intron|CCR8_ENST00000545843.1_Intron	NM_005201.3	NP_005192.1	P51685	CCR8_HUMAN	chemokine (C-C motif) receptor 8	88					cell adhesion|chemotaxis|elevation of cytosolic calcium ion concentration|immune response	integral to plasma membrane	coreceptor activity			NS(3)|breast(1)|endometrium(3)|large_intestine(5)|lung(7)|ovary(1)|skin(1)	21				KIRC - Kidney renal clear cell carcinoma(284;0.0504)|Kidney(284;0.0635)		TCTTCTCCTTCCCCTTTCAGA	0.488000													30	147					0	0	1	0	0
KMT2C	58508	broad.mit.edu	37	7	151945174	151945174	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr7:151945174G>C	ENST00000355193.2	-	14	2563	c.2345C>G	c.(2344-2346)tCt>tGt	p.S782C	KMT2C_ENST00000262189.6_Missense_Mutation_p.S782C					lysine (K)-specific methyltransferase 2C																		TGGGGAGGAAGACACATCTGC	0.428000													8	356					0	0	1	0	0
KIAA0100	9703	broad.mit.edu	37	17	26962072	26962072	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr17:26962072G>A	ENST00000528896.2	-	16	2607	c.2533C>T	c.(2533-2535)Cag>Tag	p.Q845*	KIAA0100_ENST00000389003.3_Nonsense_Mutation_p.Q702*|RP11-192H23.7_ENST00000577814.1_RNA|KIAA0100_ENST00000544884.1_Nonsense_Mutation_p.Q702*	NM_014680.3	NP_055495.2	Q14667	K0100_HUMAN	KIAA0100	845						extracellular region				breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(23)|ovary(2)|prostate(2)|skin(6)|stomach(2)|urinary_tract(3)	68	Lung NSC(42;0.00431)					AGCCACTTCTGAACTCCCACA	0.527000													43	198					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21232630	21232630	+	Silent	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr2:21232630C>T	ENST00000233242.1	-	26	7237	c.7110G>A	c.(7108-7110)ttG>ttA	p.L2370L		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	2370					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TAGTCTCCTTCAACTTGTATT	0.368000													7	28					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11038916	11038916	+	RNA	SNP	G	G	C			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr21:11038916G>C	ENST00000470054.1	-	0	1287									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TGGGGAGGAAGACACATCTGC	0.428000													7	423					0	0	1	0	0
MMP14	4323	broad.mit.edu	37	14	23314558	23314558	+	Missense_Mutation	SNP	T	T	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr14:23314558T>A	ENST00000311852.6	+	9	1661	c.1400T>A	c.(1399-1401)tTc>tAc	p.F467Y	MMP14_ENST00000548162.1_3'UTR	NM_004995.2	NP_004986.1	P50281	MMP14_HUMAN	matrix metallopeptidase 14 (membrane-inserted)	467	Hemopexin-like 4.					extracellular matrix|integral to plasma membrane|melanosome	calcium ion binding|metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(5)|prostate(1)|skin(2)|urinary_tract(1)	20	all_cancers(95;9.47e-05)			GBM - Glioblastoma multiforme(265;0.00551)		AGAGGGTCATTCATGGGCAGC	0.557000													17	39					0	0	1	0	0
ZNF829	374899	broad.mit.edu	37	19	37405914	37405914	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr19:37405914C>G	ENST00000520965.1	-	3	358	c.292G>C	c.(292-294)Gaa>Caa	p.E98Q	ZNF829_ENST00000391711.3_Missense_Mutation_p.E17Q	NM_001171979.1	NP_001165450.1	Q3KNS6	ZN829_HUMAN	zinc finger protein 829	17	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(11)|lung(8)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	29	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TCCTCCTCTTCTGGGTGACAC	0.423000													4	50					0	0	1	0	0
CCDC13	152206	broad.mit.edu	37	3	42799702	42799702	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr3:42799702C>T	ENST00000310232.6	-	2	219	c.136G>A	c.(136-138)Gac>Aac	p.D46N	CCDC13_ENST00000435327.2_5'UTR	NM_144719.3	NP_653320.3	Q8IYE1	CCD13_HUMAN	coiled-coil domain containing 13	46										endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(11)|ovary(1)|prostate(3)|skin(1)|urinary_tract(1)	25						TCCTCTTGGTCGTCAGCTCTG	0.493000													20	52					0	0	1	0	0
KIF26B	55083	broad.mit.edu	37	1	245850699	245850699	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr1:245850699G>A	ENST00000366518.4	+	9	3375	c.3271G>A	c.(3271-3273)Gct>Act	p.A1091T	KIF26B_ENST00000407071.2_Missense_Mutation_p.A1472T			Q2KJY2	KI26B_HUMAN	kinesin family member 26B	1472					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(21)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	51	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			CCCCTCGAATGCTGAGACCAG	0.597000													4	13					0	0	1	0	0
CLUAP1	23059	broad.mit.edu	37	16	3580624	3580624	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr16:3580624G>C	ENST00000571025.1	+	10	1035	c.985G>C	c.(985-987)Gaa>Caa	p.E329Q	CLUAP1_ENST00000341633.5_Missense_Mutation_p.E329Q|CLUAP1_ENST00000572600.1_Missense_Mutation_p.E163Q|CLUAP1_ENST00000445795.2_Missense_Mutation_p.E88Q|CLUAP1_ENST00000576634.1_Missense_Mutation_p.E329Q|CLUAP1_ENST00000417763.2_Missense_Mutation_p.E163Q			Q96AJ1	CLUA1_HUMAN	clusterin associated protein 1	329						nucleus	protein binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(1)|ovary(1)|pancreas(1)|urinary_tract(2)	16						CAGTGAGTTGGAAGAAAGGCG	0.547000													14	31					0	0	1	0	0
SIPA1	6494	broad.mit.edu	37	11	65417892	65417892	+	Nonsense_Mutation	SNP	C	C	G			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr11:65417892C>G	ENST00000394224.3	+	15	3220	c.2924C>G	c.(2923-2925)tCa>tGa	p.S975*	SIPA1_ENST00000394227.3_Nonsense_Mutation_p.S873*|SIPA1_ENST00000527525.1_Nonsense_Mutation_p.S873*|SIPA1_ENST00000534313.1_Nonsense_Mutation_p.S975*	NM_153253.29	NP_694985.29	Q96FS4	SIPA1_HUMAN	signal-induced proliferation-associated 1	975					cell proliferation|cytoskeleton organization|intracellular signal transduction|negative regulation of cell adhesion|negative regulation of cell cycle|negative regulation of cell growth	cytosol|endomembrane system|membrane|perinuclear region of cytoplasm	Rap GTPase activator activity			cervix(1)|endometrium(2)|large_intestine(2)|lung(3)|prostate(1)|urinary_tract(1)	10						GGGAACCTCTCAGAGAAGGTC	0.622000													10	94					0	0	1	0	0
PTK2B	2185	broad.mit.edu	37	8	27291621	27291621	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr8:27291621C>T	ENST00000397501.1	+	17	1925	c.1117C>T	c.(1117-1119)Cgg>Tgg	p.R373W	PTK2B_ENST00000544172.1_Missense_Mutation_p.R373W|PTK2B_ENST00000397497.4_Missense_Mutation_p.R119W|PTK2B_ENST00000517339.1_Missense_Mutation_p.R373W|PTK2B_ENST00000420218.2_Missense_Mutation_p.R373W|PTK2B_ENST00000346049.5_Missense_Mutation_p.R373W|PTK2B_ENST00000338238.4_Missense_Mutation_p.R373W	NM_173174.2	NP_775266.1	Q14289	FAK2_HUMAN	protein tyrosine kinase 2 beta	373					apoptosis|bone resorption|positive regulation of cell proliferation|signal complex assembly	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|signal transducer activity			breast(2)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(17)|ovary(4)|skin(12)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	47		Ovarian(32;2.72e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|Epithelial(17;6.61e-10)|BRCA - Breast invasive adenocarcinoma(99;0.226)|Colorectal(74;0.229)		TGGTGAGAAGCGGAACAGCCT	0.562000													16	108					0	0	1	0	0
BEGAIN	57596	broad.mit.edu	37	14	101004846	101004846	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr14:101004846C>G	ENST00000556751.1	-	5	4454	c.1050G>C	c.(1048-1050)atG>atC	p.M350I	BEGAIN_ENST00000355173.2_Missense_Mutation_p.M414I|BEGAIN_ENST00000443071.2_Missense_Mutation_p.M414I			Q9BUH8	BEGIN_HUMAN	brain-enriched guanylate kinase-associated	414						cytoplasm|membrane	protein binding			cervix(1)|endometrium(4)|large_intestine(2)|lung(3)|prostate(1)|skin(2)|stomach(1)	14		Melanoma(154;0.212)				ACTGGCCCCTCATGTCCTCCC	0.726000													3	26					0	0	1	0	0
GOPC	57120	broad.mit.edu	37	6	117890829	117890829	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr6:117890829C>T	ENST00000535237.1	-	7	1212	c.983G>A	c.(982-984)gGa>gAa	p.G328E	GOPC_ENST00000467125.1_5'UTR|GOPC_ENST00000368498.2_Missense_Mutation_p.G328E|GOPC_ENST00000052569.6_Missense_Mutation_p.G320E|DCBLD1_ENST00000296955.8_3'UTR					golgi-associated PDZ and coiled-coil motif containing										GOPC/ROS1(14)	endometrium(1)|large_intestine(3)|lung(4)|ovary(1)	9		all_cancers(87;0.00844)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0363)|OV - Ovarian serous cystadenocarcinoma(136;0.0821)|all cancers(137;0.0976)		GTGCAGCCCTCCGCATCTATC	0.458000			O	ROS1	glioblastoma								33	196					0	0	1	0	0
LRP6	4040	broad.mit.edu	37	12	12334167	12334167	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr12:12334167G>A	ENST00000261349.4	-	6	1259	c.1183C>T	c.(1183-1185)Cag>Tag	p.Q395*	LRP6_ENST00000543091.1_Nonsense_Mutation_p.Q395*	NM_002336.2	NP_002327.2	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein 6	395	Beta-propeller 2.				cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(28)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	85		Prostate(47;0.0865)				ACCACAAACTGACTGCCAGAT	0.468000													13	106					0	0	1	0	0
RNASE9	390443	broad.mit.edu	37	14	21024726	21024726	+	Missense_Mutation	SNP	C	C	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr14:21024726C>A	ENST00000557068.1	-	4	2228	c.503G>T	c.(502-504)tGt>tTt	p.C168F	RNASE9_ENST00000557209.1_Missense_Mutation_p.C173F|RNASE9_ENST00000429244.2_Missense_Mutation_p.C168F|RNASE9_ENST00000556208.1_Missense_Mutation_p.C173F|RNASE9_ENST00000553706.1_Missense_Mutation_p.C173F|RNASE9_ENST00000338904.3_Missense_Mutation_p.C168F|RNASE9_ENST00000553541.1_Missense_Mutation_p.C168F|RNASE9_ENST00000554964.1_Missense_Mutation_p.C168F|RNASE9_ENST00000555230.1_Missense_Mutation_p.C168F|RNASE9_ENST00000404716.3_Missense_Mutation_p.C173F			P60153	RNAS9_HUMAN	ribonuclease, RNase A family, 9 (non-active)	168						extracellular region	nucleic acid binding|pancreatic ribonuclease activity			haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|ovary(2)|urinary_tract(1)	8	all_cancers(95;0.00238)		Epithelial(56;3.32e-06)|all cancers(55;2.46e-05)	GBM - Glioblastoma multiforme(265;0.0141)		TTGCCATGAACAAGTGATAAG	0.388000													5	34					0.014758	0.014927	1	1	0
MIS18BP1	55320	broad.mit.edu	37	14	45686255	45686255	+	Silent	SNP	G	G	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr14:45686255G>A	ENST00000310806.4	-	13	3428	c.2970C>T	c.(2968-2970)ttC>ttT	p.F990F		NM_018353.4	NP_060823.3	Q6P0N0	M18BP_HUMAN	MIS18 binding protein 1	990					cell division|CenH3-containing nucleosome assembly at centromere|mitosis	chromosome, centromeric region|nucleoplasm	DNA binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(10)|liver(1)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	39						GTGTTGTACTGAAAAAATCAT	0.338000													14	98					0	0	1	0	0
SPATA2L	124044	broad.mit.edu	37	16	89764256	89764256	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr16:89764256G>A	ENST00000289805.5	-	3	829	c.761C>T	c.(760-762)cCg>cTg	p.P254L	SPATA2L_ENST00000335360.7_Intron	NM_152339.3	NP_689552.2	Q8IUW3	SPA2L_HUMAN	spermatogenesis associated 2-like	254										breast(1)|cervix(1)|endometrium(1)|lung(2)|skin(1)	6		Lung NSC(15;0.00043)|all_lung(18;0.000665)|all_hematologic(23;0.0355)		BRCA - Breast invasive adenocarcinoma(80;0.0272)		CAGCTCCGCCGGGGGCGAGTC	0.692000													6	18					0	0	1	0	0
ZNF878	729747	broad.mit.edu	37	19	12155088	12155088	+	Silent	SNP	G	G	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr19:12155088G>A	ENST00000602107.1	-	5	1268	c.1269C>T	c.(1267-1269)ttC>ttT	p.F423F	CTD-2006C1.10_ENST00000547473.1_Intron|CTD-2006C1.2_ENST00000476474.1_RNA|CTD-2006C1.2_ENST00000591898.1_RNA|CTD-2006C1.2_ENST00000591838.1_RNA|ZNF878_ENST00000547628.1_Silent_p.F376F			C9JN71	ZN878_HUMAN	zinc finger protein 878	376					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			cervix(1)|endometrium(1)|kidney(1)|lung(4)|urinary_tract(1)	8						TGGAAGAAGTGAAGGTTTTCC	0.423000													10	48					0	0	1	0	0
ANKRD50	57182	broad.mit.edu	37	4	125590426	125590426	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr4:125590426G>C	ENST00000504087.1	-	4	5043	c.4006C>G	c.(4006-4008)Cag>Gag	p.Q1336E	ANKRD50_ENST00000515641.1_Missense_Mutation_p.Q1157E	NM_020337.2	NP_065070.1	Q9ULJ7	ANR50_HUMAN	ankyrin repeat domain 50	1336								p.Q1336*(1)		NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(14)|lung(18)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	55						ATTTCCTGCTGAGCTGAAGGT	0.403000													14	109					0	0	1	0	0
SYNE2	23224	broad.mit.edu	37	14	64596788	64596788	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr14:64596788G>A	ENST00000357395.3	+	77	14461	c.3317G>A	c.(3316-3318)gGa>gAa	p.G1106E	ESR2_ENST00000542956.1_Intron|SYNE2_ENST00000554584.1_Missense_Mutation_p.G4638E|SYNE2_ENST00000394768.2_Missense_Mutation_p.G1106E|SYNE2_ENST00000344113.4_Missense_Mutation_p.G4721E|SYNE2_ENST00000555002.1_Missense_Mutation_p.G1355E|SYNE2_ENST00000358025.3_Missense_Mutation_p.G4721E			Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	4721					centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		AGTATGTGGGGAATGCTAAGA	0.478000													23	51					0	0	1	0	0
ZBTB37	84614	broad.mit.edu	37	1	173839393	173839393	+	Missense_Mutation	SNP	G	G	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr1:173839393G>T	ENST00000367704.1	+	3	429	c.30G>T	c.(28-30)gaG>gaT	p.E10D	ZBTB37_ENST00000427304.1_Missense_Mutation_p.E10D|ZBTB37_ENST00000367701.4_Missense_Mutation_p.E10D|ZBTB37_ENST00000367702.1_Missense_Mutation_p.E10D|ZBTB37_ENST00000432989.1_Missense_Mutation_p.E10D			Q5TC79	ZBT37_HUMAN	zinc finger and BTB domain containing 37	10					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(1)|urinary_tract(4)	13						TACAATTGGAGATTCCTGACT	0.433000													5	31					0.014758	0.014927	1	1	0
PRSS38	339501	broad.mit.edu	37	1	228003458	228003458	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr1:228003458C>T	ENST00000366757.3	+	1	65	c.41C>T	c.(40-42)tCt>tTt	p.S14F		NM_183062.2	NP_898885.1	A1L453	PRS38_HUMAN	protease, serine, 38	14					proteolysis	extracellular region	serine-type endopeptidase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23						CTCGGGCCCTCTGCCCTGGGC	0.667000													10	32					0	0	1	0	0
ATF4	468	broad.mit.edu	37	22	39917519	39917519	+	Silent	SNP	G	G	C			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr22:39917519G>C	ENST00000337304.2	+	1	951	c.69G>C	c.(67-69)tcG>tcC	p.S23S	ATF4_ENST00000396680.1_Silent_p.S23S|ATF4_ENST00000404241.2_Silent_p.S23S	NM_001675.2	NP_001666.2	P18848	ATF4_HUMAN	activating transcription factor 4	23					cellular amino acid metabolic process|gluconeogenesis|positive regulation of transcription from RNA polymerase II promoter|response to endoplasmic reticulum stress|transcription from RNA polymerase II promoter	cytoplasm|plasma membrane	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(2)|large_intestine(2)|lung(5)|skin(1)	11	Melanoma(58;0.04)					TCGACCAGTCGGGTTTGGGGG	0.552000													18	137					0	0	1	0	0
CADM2	253559	broad.mit.edu	37	3	85851334	85851334	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr3:85851334G>C	ENST00000383699.3	+	3	853	c.226G>C	c.(226-228)Gac>Cac	p.D76H	CADM2_ENST00000407528.2_Missense_Mutation_p.D67H|CADM2_ENST00000405615.2_Missense_Mutation_p.D69H|CADM2-AS2_ENST00000467225.1_RNA	NM_001167675.1|NM_001256504.1|NM_001256505.1	NP_001161147.1|NP_001243433.1|NP_001243434.1	Q8N3J6	CADM2_HUMAN	cell adhesion molecule 2	67	Ig-like V-type.				adherens junction organization|cell junction assembly	integral to membrane|plasma membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(15)|ovary(1)|prostate(1)|skin(4)	38		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		TCTGTACTTTGACGACAAGAA	0.343000													7	40					0	0	1	0	0
FRYL	285527	broad.mit.edu	37	4	48546828	48546828	+	Silent	SNP	C	C	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr4:48546828C>A	ENST00000537810.1	-	43	5977	c.5373G>T	c.(5371-5373)gtG>gtT	p.V1791V	FRYL_ENST00000503238.1_Silent_p.V1791V|FRYL_ENST00000264319.7_5'UTR|FRYL_ENST00000507873.2_5'UTR|FRYL_ENST00000358350.4_Silent_p.V1791V			O94915	FRYL_HUMAN	FRY-like	1791					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(21)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	91						AAACAGAAACCACATGTTTCA	0.338000													13	36					5.50884e-06	5.77013e-06	1	1	0
TRPS1	7227	broad.mit.edu	37	8	116631647	116631647	+	Silent	SNP	T	T	G			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr8:116631647T>G	ENST00000395715.3	-	3	1255	c.678A>C	c.(676-678)gcA>gcC	p.A226A	TRPS1_ENST00000519076.1_Silent_p.A167A|TRPS1_ENST00000519674.1_Silent_p.A213A|TRPS1_ENST00000220888.5_Silent_p.A213A|TRPS1_ENST00000520276.1_Silent_p.A217A	NM_014112.2	NP_054831.2	Q9UHF7	TRPS1_HUMAN	trichorhinophalangeal syndrome I	213					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(58)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|urinary_tract(2)	111	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			GAGACAGAGGTGCCGGGTCTG	0.458000									Langer-Giedion syndrome				23	201					0	0	1	0	0
KCTD12	115207	broad.mit.edu	37	13	77460092	77460092	+	Silent	SNP	G	G	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr13:77460092G>A	ENST00000377474.2	-	1	433	c.192C>T	c.(190-192)ttC>ttT	p.F64F	KCTD12_ENST00000317765.2_Silent_p.F64F	NM_138444.3	NP_612453.1	Q96CX2	KCD12_HUMAN	potassium channel tetramerization domain containing 12	64						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			kidney(1)|large_intestine(1)|lung(1)|ovary(1)	4		Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.0499)		GCTGCTGCGTGAACATGCGCC	0.662000													5	12					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82595703	82595703	+	Missense_Mutation	SNP	G	G	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr7:82595703G>T	ENST00000423517.2	-	4	3738	c.3401C>A	c.(3400-3402)gCa>gAa	p.A1134E	PCLO_ENST00000333891.8_Missense_Mutation_p.A1134E	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	1073					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity	p.A1134V(2)|p.A1073V(1)		breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						CATAGGAGATGCTTTGGGTCC	0.423000													13	76					0.00010058	0.000104524	1	1	0
CACNA2D1	781	broad.mit.edu	37	7	81978949	81978949	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr7:81978949C>G	ENST00000356860.3	-	2	450	c.112G>C	c.(112-114)Gat>Cat	p.D38H	CACNA2D1_ENST00000356253.5_Missense_Mutation_p.D38H|CACNA2D1_ENST00000423588.1_Missense_Mutation_p.D38H	NM_000722.2	NP_000713.2	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 1	38						voltage-gated calcium channel complex	metal ion binding			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(15)|liver(1)|lung(42)|ovary(6)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	81					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	TGCATCTTATCCACCCATGAT	0.368000													11	71					0	0	1	0	0
GLB1L	79411	broad.mit.edu	37	2	220102441	220102441	+	Silent	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr2:220102441C>T	ENST00000295759.7	-	16	1795	c.1482G>A	c.(1480-1482)ttG>ttA	p.L494L	GLB1L_ENST00000497855.1_5'UTR|GLB1L_ENST00000409640.1_Silent_p.L404L|GLB1L_ENST00000356283.3_Silent_p.L404L|GLB1L_ENST00000392089.2_Silent_p.L494L			Q6UWU2	GLB1L_HUMAN	galactosidase, beta 1-like	494					carbohydrate metabolic process	extracellular region	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	22		all_lung(227;1.19e-05)|Lung NSC(271;2.76e-05)|Medulloblastoma(418;0.0208)|Esophageal squamous(248;0.0559)		Epithelial(149;1.3e-11)|all cancers(144;2.07e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TTGGTGGCTTCAACAGGCCCT	0.433000													24	55					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32841311	32841311	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr13:32841311G>A	ENST00000380250.3	+	55	8447	c.7951G>A	c.(7951-7953)Gga>Aga	p.G2651R	FRY_ENST00000542859.1_Missense_Mutation_p.G21R	NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	2651					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		TTCCAGCTTTGGAGAAGGTGA	0.517000													11	93					0	0	1	0	0
GNB3	2784	broad.mit.edu	37	12	6952678	6952678	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr12:6952678C>G	ENST00000229264.3	+	7	824	c.419C>G	c.(418-420)tCt>tGt	p.S140C	GNB3_ENST00000435982.2_Missense_Mutation_p.S140C	NM_002075.2	NP_002066.1	P16520	GBB3_HUMAN	guanine nucleotide binding protein (G protein), beta polypeptide 3	140					cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of blood pressure|synaptic transmission	plasma membrane	GTPase activity|GTPase binding|signal transducer activity			cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(7)|prostate(1)|stomach(1)	20						CGGGAGCTTTCTGCTCACACA	0.597000													22	94					0	0	1	0	0
OR1S1	219959	broad.mit.edu	37	11	57982336	57982336	+	Silent	SNP	C	C	G			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr11:57982336C>G	ENST00000309433.6	+	1	120	c.120C>G	c.(118-120)ctC>ctG	p.L40L		NM_001004458.1	NP_001004458.1	Q8NH92	OR1S1_HUMAN	olfactory receptor, family 1, subfamily S, member 1	40					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(24)|kidney(1)|large_intestine(1)|liver(1)|lung(10)|prostate(1)|skin(2)|stomach(3)|urinary_tract(3)	48		Breast(21;0.0589)				AAAACCTCCTCTTTGTGCTTT	0.448000													43	110					0	0	1	0	0
RASGRF1	5923	broad.mit.edu	37	15	79291097	79291097	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr15:79291097C>G	ENST00000419573.3	-	19	3139	c.2865G>C	c.(2863-2865)ttG>ttC	p.L955F	RASGRF1_ENST00000558480.2_Missense_Mutation_p.L939F|RASGRF1_ENST00000560334.1_5'UTR|RASGRF1_ENST00000394745.3_Missense_Mutation_p.L171F	NM_002891.4	NP_002882.3	Q13972	RGRF1_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 1	957					activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(18)|lung(23)|ovary(2)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						GGAGCACGTTCAAGACACGAT	0.632000													14	88					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578403	7578403	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr17:7578403C>T	ENST00000420246.2	-	5	659	c.527G>A	c.(526-528)tGc>tAc	p.C176Y	TP53_ENST00000455263.2_Missense_Mutation_p.C176Y|TP53_ENST00000445888.2_Missense_Mutation_p.C176Y|TP53_ENST00000269305.4_Missense_Mutation_p.C176Y|TP53_ENST00000574684.1_5'UTR|TP53_ENST00000413465.2_Missense_Mutation_p.C176Y|TP53_ENST00000359597.4_Missense_Mutation_p.C176Y	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	176	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		C -> F (in sporadic cancers; somatic mutation).|C -> G (in sporadic cancers; somatic mutation).|C -> R (in sporadic cancers; somatic mutation).|C -> S (in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> Y (in sporadic cancers; somatic mutation).|CP -> FS (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C176F(129)|p.C176Y(63)|p.C83F(9)|p.C44F(9)|p.C176S(8)|p.0?(8)|p.C176_R181delCPHHER(3)|p.R174fs*24(3)|p.C44Y(3)|p.C83Y(3)|p.R175_E180delRCPHHE(3)|p.V173fs*59(2)|p.R174fs*1(2)|p.V157_C176del20(1)|p.C176fs*65(1)|p.C176_P177delCP(1)|p.V173fs*69(1)|p.C176fs*68(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.R174_H178>S(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.R175_H178>X(1)|p.R42fs*24(1)|p.R174_C176delRRC(1)|p.H168fs*69(1)|p.R174fs*70(1)|p.C176del(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.H178fs*3(1)|p.R174fs*3(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATGGTGGGGGCAGCGCCTCAC	0.652000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			25	31					0	0	1	0	0
ACACB	32	broad.mit.edu	37	12	109677702	109677702	+	Missense_Mutation	SNP	A	A	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr12:109677702A>T	ENST00000338432.7	+	35	4849	c.4730A>T	c.(4729-4731)gAg>gTg	p.E1577V	ACACB_ENST00000543201.1_Missense_Mutation_p.E243V|ACACB_ENST00000377848.3_Missense_Mutation_p.E1577V|ACACB_ENST00000377854.5_Missense_Mutation_p.E1507V			O00763	ACACB_HUMAN	acetyl-CoA carboxylase beta	1577					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(1)|breast(2)|endometrium(9)|kidney(5)|large_intestine(20)|lung(40)|ovary(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95					Biotin(DB00121)	GACGAGCTGGAGGTGGCGTTC	0.597000													16	82					0	0	1	0	0
L3MBTL4	91133	broad.mit.edu	37	18	6239864	6239864	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr18:6239864G>C	ENST00000400104.3	-	9	760	c.560C>G	c.(559-561)cCa>cGa	p.P187R	L3MBTL4_ENST00000535782.1_5'UTR|L3MBTL4_ENST00000400105.2_Missense_Mutation_p.P187R|L3MBTL4_ENST00000317931.7_Missense_Mutation_p.P187R|L3MBTL4_ENST00000284898.6_Missense_Mutation_p.P187R			Q8NA19	LMBL4_HUMAN	l(3)mbt-like 4 (Drosophila)	187					chromatin modification	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(17)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		Colorectal(10;0.0249)				TTTAGACATTGGCCCATTCTA	0.468000													15	64					0	0	1	0	0
KAT6B	23522	broad.mit.edu	37	10	76739009	76739009	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr10:76739009G>A	ENST00000287239.4	+	10	2632	c.2143G>A	c.(2143-2145)Gac>Aac	p.D715N	KAT6B_ENST00000372725.1_Missense_Mutation_p.D423N|KAT6B_ENST00000372724.1_Missense_Mutation_p.D423N|KAT6B_ENST00000372714.1_Missense_Mutation_p.D423N|KAT6B_ENST00000372711.1_Missense_Mutation_p.D532N|KAT6B_ENST00000490365.1_3'UTR	NM_001256468.1|NM_012330.3	NP_001243397.1|NP_036462.2	Q8WYB5	MYST4_HUMAN	K(lysine) acetyltransferase 6B	715	Negatively regulates HAT activity.				histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding										TGGGGTGGAAGACTGTGGCCG	0.378000													4	48					0	0	1	0	0
RASIP1	54922	broad.mit.edu	37	19	49232825	49232825	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr19:49232825G>A	ENST00000222145.4	-	5	1406	c.1202C>T	c.(1201-1203)aCg>aTg	p.T401M	RASIP1_ENST00000594232.1_5'UTR	NM_017805.2	NP_060275.2	Q5U651	RAIN_HUMAN	Ras interacting protein 1	401					signal transduction	Golgi stack|perinuclear region of cytoplasm				central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(7)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	21		all_lung(116;4.89e-06)|all_epithelial(76;7.04e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;9.98e-05)|all cancers(93;0.000272)|Epithelial(262;0.0155)|GBM - Glioblastoma multiforme(486;0.0222)		CTGCTCTCGCGTCATCACATA	0.557000													3	15					0	0	1	0	0
SLIT2	9353	broad.mit.edu	37	4	20535220	20535220	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr4:20535220G>A	ENST00000504154.1	+	18	1966	c.1714G>A	c.(1714-1716)Gat>Aat	p.D572N	SLIT2_ENST00000503823.1_Missense_Mutation_p.D564N|SLIT2_ENST00000503837.1_Missense_Mutation_p.D568N|SLIT2_ENST00000273739.5_Missense_Mutation_p.D576N	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	572					apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						TAAGATCACAGATATTGAGGA	0.318000													6	54					0	0	1	0	0
PCDHA13	56136	broad.mit.edu	37	5	140263604	140263604	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr5:140263604C>T	ENST00000289272.2	+	1	1751	c.1751C>T	c.(1750-1752)tCg>tTg	p.S584L	PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA13_ENST00000409494.1_Missense_Mutation_p.S584L	NM_018904.2|NM_031865.1	NP_061727.1|NP_114071.1														NS(1)|biliary_tract(2)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(18)|liver(3)|lung(23)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGCCGCGGTCGGTGGGTGCA	0.687000													24	148					0	0	1	0	0
PRPF40B	25766	broad.mit.edu	37	12	50037079	50037079	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr12:50037079C>T	ENST00000261897.1	+	22	2728	c.2177C>T	c.(2176-2178)tCa>tTa	p.S726L	PRPF40B_ENST00000548825.2_Missense_Mutation_p.S760L|PRPF40B_ENST00000380281.1_Missense_Mutation_p.S739L|FMNL3_ENST00000335154.5_3'UTR			Q6NWY9	PR40B_HUMAN	PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae)	739					mRNA processing|RNA splicing	nuclear speck				breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	34						CGGAACCCCTCAGAGTCAGGC	0.607000													24	105					0	0	1	0	0
PRR15L	79170	broad.mit.edu	37	17	46030325	46030325	+	Silent	SNP	G	G	C			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr17:46030325G>C	ENST00000300557.2	-	2	526	c.276C>G	c.(274-276)ctC>ctG	p.L92L	RP11-6N17.9_ENST00000582262.1_RNA	NM_024320.3	NP_077296.1	Q9BU68	PR15L_HUMAN	proline rich 15-like	92										NS(1)|cervix(1)|ovary(1)|pancreas(1)	4						GATCATCAAAGAGGTTAGGGT	0.542000													10	95					0	0	1	0	0
KIF7	374654	broad.mit.edu	37	15	90172250	90172250	+	Silent	SNP	C	C	G	rs138986036	byFrequency	TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr15:90172250C>G	ENST00000394412.3	-	18	3697	c.3621G>C	c.(3619-3621)ctG>ctC	p.L1207L		NM_198525.2	NP_940927.2	Q2M1P5	KIF7_HUMAN	kinesin family member 7	1207					microtubule-based movement|negative regulation of smoothened signaling pathway|positive regulation of smoothened signaling pathway	cilium	ATP binding|microtubule motor activity|protein binding			central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(5)|lung(11)|ovary(2)|stomach(1)|urinary_tract(1)	25	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			GCTTCTGTTTCAGTTCCTGGT	0.547000													21	120					0	0	1	0	0
MAST1	22983	broad.mit.edu	37	19	12978692	12978692	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr19:12978692C>T	ENST00000251472.4	+	20	2506	c.2467C>T	c.(2467-2469)Ccc>Tcc	p.P823S		NM_014975.2	NP_055790.1	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase 1	823					cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(20)|ovary(5)|prostate(5)|skin(3)	56						GCGCAGGCCTCCCCGGCCCAG	0.736000													6	20					0	0	1	0	0
ACSS3	79611	broad.mit.edu	37	12	81613830	81613830	+	Missense_Mutation	SNP	C	C	T	rs142377880		TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr12:81613830C>T	ENST00000548058.1	+	11	2399	c.1489C>T	c.(1489-1491)Cgg>Tgg	p.R497W	ACSS3_ENST00000548324.1_Missense_Mutation_p.R179W|ACSS3_ENST00000261206.3_Missense_Mutation_p.R496W			Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	497						mitochondrion	acetate-CoA ligase activity|ATP binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(7)|liver(3)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)	51						ACTGAAGGCTCGGTGTTTAGG	0.269000													8	63					0	0	1	0	0
NAV3	89795	broad.mit.edu	37	12	78593297	78593297	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr12:78593297C>G	ENST00000397909.2	+	37	6874	c.6701C>G	c.(6700-6702)tCt>tGt	p.S2234C	NAV3_ENST00000228327.6_Missense_Mutation_p.S2212C|NAV3_ENST00000266692.7_Missense_Mutation_p.S2035C|NAV3_ENST00000541270.1_Missense_Mutation_p.S64C|NAV3_ENST00000536525.2_Missense_Mutation_p.S2212C			Q8IVL0	NAV3_HUMAN	neuron navigator 3	2234						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						CACAGTTCTTCTGACGTTACC	0.373000										HNSCC(70;0.22)			8	57					0	0	1	0	0
LGI4	163175	broad.mit.edu	37	19	35616130	35616130	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr19:35616130G>C	ENST00000310123.3	-	9	2100	c.1581C>G	c.(1579-1581)atC>atG	p.I527M	LGI4_ENST00000392225.3_3'UTR|LGI4_ENST00000493050.1_5'UTR	NM_139284.2	NP_644813.1	Q8N135	LGI4_HUMAN	leucine-rich repeat LGI family, member 4	527						extracellular region				endometrium(1)|large_intestine(1)|lung(4)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10	all_lung(56;7.56e-09)|Lung NSC(56;1.1e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.54e-20)|OV - Ovarian serous cystadenocarcinoma(14;1.33e-18)|all cancers(14;4.27e-17)|LUSC - Lung squamous cell carcinoma(66;0.0849)			GATGCTGGTAGATCTGTGTGG	0.652000													15	89					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113694784	113694784	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr8:113694784G>T	ENST00000297405.5	-	16	2808	c.2564C>A	c.(2563-2565)tCa>tAa	p.S855*	CSMD3_ENST00000455883.2_Nonsense_Mutation_p.S751*|CSMD3_ENST00000352409.3_Nonsense_Mutation_p.S855*|CSMD3_ENST00000343508.3_Nonsense_Mutation_p.S815*	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	855	Sushi 4.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						AACTGAAATTGAACTTCCTAA	0.358000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			17	106					3.41278e-10	3.61755e-10	1	1	0
PCDHGB2	56103	broad.mit.edu	37	5	140740503	140740503	+	Silent	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr5:140740503C>T	ENST00000522605.1	+	1	801	c.801C>T	c.(799-801)acC>acT	p.T267T	PCDHGB1_ENST00000523390.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018923.2|NM_032096.1	NP_061746.1|NP_115267.1														endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	14			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGACAGCCACCGACCGGGATG	0.493000													13	34					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70331690	70331690	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr11:70331690C>T	ENST00000338508.4	-	32	4710	c.4711G>A	c.(4711-4713)Gaa>Aaa	p.E1571K	SHANK2_ENST00000409161.1_Missense_Mutation_p.E974K|SHANK2_ENST00000423696.2_Missense_Mutation_p.E1191K|SHANK2_ENST00000449833.2_Missense_Mutation_p.E975K			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	1191					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			TCTACATCTTCTTCCACGAGC	0.552000													135	1146					0	0	1	0	0
SERPINA10	51156	broad.mit.edu	37	14	94756848	94756848	+	Missense_Mutation	SNP	G	G	C	rs2232697		TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr14:94756848G>C	ENST00000554723.1	-	2	621	c.203C>G	c.(202-204)tCg>tGg	p.S68W	SERPINA10_ENST00000393096.1_Missense_Mutation_p.S28W|SERPINA10_ENST00000554173.1_Missense_Mutation_p.S28W|SERPINA10_ENST00000261994.4_Missense_Mutation_p.S28W			Q9UK55	ZPI_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10	28					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity	p.S28L(1)		haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(4)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	33		all_cancers(154;0.105)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)		GGTCTCTGGCGACTGAGGACT	0.642000													17	23					0	0	1	0	0
CYP4A22	284541	broad.mit.edu	37	1	47607908	47607908	+	Splice_Site	SNP	G	G	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr1:47607908G>T	ENST00000371891.3	+	4	541		c.e4+1		CYP4A22_ENST00000294337.3_Splice_Site|CYP4A22_ENST00000371890.3_Splice_Site|CYP4A22_ENST00000485117.1_Splice_Site|CYP4A22-AS1_ENST00000444042.2_lincRNA	NM_001010969.2	NP_001010969.2	Q5TCH4	CP4AM_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 22							endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						AGTGATGCTGGTGAGTCCATG	0.557000													8	66					0.000157383	0.000162916	1	1	0
RIMBP2	23504	broad.mit.edu	37	12	130912804	130912804	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr12:130912804C>T	ENST00000261655.4	-	12	2444	c.2281G>A	c.(2281-2283)Gag>Aag	p.E761K		NM_015347.4	NP_056162.4	O15034	RIMB2_HUMAN	RIMS binding protein 2	761						cell junction|synapse				NS(2)|breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(33)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	96	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		AGCTCCTCCTCGTCCTCCTCC	0.617000													26	60					0	0	1	0	0
MYT1L	23040	broad.mit.edu	37	2	1855422	1855422	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr2:1855422G>C	ENST00000399161.2	-	19	3512	c.2765C>G	c.(2764-2766)tCt>tGt	p.S922C	MYT1L_ENST00000428368.2_Missense_Mutation_p.S920C	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	922					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		CCTCCGATGAGAAGCATAATT	0.433000													13	112					0	0	1	0	0
ANKRD20A8P	729171	broad.mit.edu	37	2	95522772	95522772	+	RNA	SNP	T	T	C			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr2:95522772T>C	ENST00000432432.2	-	0	255					NR_040113.1													p.E49G(1)									GCGCTCCACCTCCGCGGCGTC	0.682000													6	104					0	0	1	0	0
BBS10	79738	broad.mit.edu	37	12	76740853	76740853	+	Silent	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr12:76740853C>T	ENST00000393262.3	-	2	995	c.912G>A	c.(910-912)caG>caA	p.Q304Q		NM_024685.3	NP_078961.3	Q8TAM1	BBS10_HUMAN	Bardet-Biedl syndrome 10	304					cellular protein metabolic process|nonmotile primary cilium assembly|photoreceptor cell maintenance|response to stimulus|retina homeostasis	cilium	ATP binding			endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(1)	19						ATTTTACATTCTGACTATGTA	0.338000									Bardet-Biedl syndrome				6	24					0	0	1	0	0
CAPN2	824	broad.mit.edu	37	1	223943283	223943283	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr1:223943283C>G	ENST00000295006.5	+	10	1546	c.1237C>G	c.(1237-1239)Cag>Gag	p.Q413E	CAPN2_ENST00000433674.2_Missense_Mutation_p.Q335E	NM_001748.4	NP_001739.2	P17655	CAN2_HUMAN	calpain 2, (m/II) large subunit	413	Domain III.				proteolysis	cytoplasm|plasma membrane				breast(3)|endometrium(1)|kidney(1)|large_intestine(9)|lung(10)|prostate(1)|skin(1)|stomach(3)	29				GBM - Glioblastoma multiforme(131;0.109)		GGGGCTCATTCAGAAGCACCG	0.607000													27	52					0	0	1	0	0
ITSN2	50618	broad.mit.edu	37	2	24480820	24480820	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr2:24480820C>T	ENST00000355123.4	-	23	3268	c.2825G>A	c.(2824-2826)gGa>gAa	p.G942E	ITSN2_ENST00000406921.3_Missense_Mutation_p.G942E|ITSN2_ENST00000361999.3_Missense_Mutation_p.G915E	NM_006277.2	NP_006268.2	Q9NZM3	ITSN2_HUMAN	intersectin 2	942	SH3 2.				endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(8)|large_intestine(11)|liver(3)|lung(28)|ovary(2)|stomach(1)	61	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCATCCTCTTCCTCCATGCAC	0.408000													13	90					0	0	1	0	0
DHX37	57647	broad.mit.edu	37	12	125432580	125432580	+	Silent	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr12:125432580C>T	ENST00000544745.1	-	23	2908	c.2799G>A	c.(2797-2799)ctG>ctA	p.L933L	DHX37_ENST00000308736.2_Intron			Q8IY37	DHX37_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 37	0							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			breast(5)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(11)|liver(1)|lung(27)|ovary(1)|prostate(2)|skin(3)	65	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;8.05e-05)|Epithelial(86;0.000486)|all cancers(50;0.00653)		GCCCCTGCCTCAGTGACCCCA	0.597000													16	27					0	0	1	0	0
RBM12	10137	broad.mit.edu	37	20	34242341	34242341	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr20:34242341C>G	ENST00000374114.3	-	3	1167	c.904G>C	c.(904-906)Gat>Cat	p.D302H	CPNE1_ENST00000397442.1_Intron|RBM12_ENST00000374104.3_Missense_Mutation_p.D302H|CPNE1_ENST00000397443.1_Intron|CPNE1_ENST00000352393.4_Intron|CPNE1_ENST00000397446.1_Intron|RBM12_ENST00000359646.1_Missense_Mutation_p.D302H|CPNE1_ENST00000317619.3_Intron|CPNE1_ENST00000397445.1_Intron	NM_001198838.1|NM_001198840.1|NM_006047.5	NP_001185767.1|NP_001185769.1|NP_006038.2	Q9NTZ6	RBM12_HUMAN	RNA binding motif protein 12	302						nucleus	nucleotide binding|protein binding|RNA binding			breast(3)|endometrium(7)|kidney(1)|large_intestine(3)|lung(14)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36	Lung NSC(9;0.00608)|all_lung(11;0.00918)		BRCA - Breast invasive adenocarcinoma(18;0.00953)			TACAGATCATCAGGGTTGATG	0.433000													33	74					0	0	1	0	0
NAV3	89795	broad.mit.edu	37	12	78531100	78531100	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr12:78531100C>G	ENST00000397909.2	+	19	4758	c.4585C>G	c.(4585-4587)Cgt>Ggt	p.R1529G	NAV3_ENST00000228327.6_Missense_Mutation_p.R1529G|NAV3_ENST00000266692.7_Missense_Mutation_p.R1352G|NAV3_ENST00000536525.2_Missense_Mutation_p.R1529G			Q8IVL0	NAV3_HUMAN	neuron navigator 3	1529	Ser-rich.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity	p.R1529S(1)		NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						GGAAAGACCTCGTGCCATCAG	0.493000										HNSCC(70;0.22)			13	82					0	0	1	0	0
TPR	7175	broad.mit.edu	37	1	186315292	186315292	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr1:186315292C>T	ENST00000367478.3	-	23	3367	c.3071G>A	c.(3070-3072)aGa>aAa	p.R1024K		NM_003292.2	NP_003283.2	P12270	TPR_HUMAN	translocated promoter region, nuclear basket protein	1024					carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			autonomic_ganglia(1)|breast(5)|central_nervous_system(4)|cervix(2)|endometrium(9)|kidney(12)|large_intestine(23)|liver(1)|lung(45)|ovary(2)|pancreas(1)|prostate(6)|skin(3)|stomach(1)|urinary_tract(8)	123		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		CTCTATGGCTCTTCTTTTATC	0.333000			T	NTRK1	papillary thyroid								10	39					0	0	1	0	0
ATRNL1	26033	broad.mit.edu	37	10	116919891	116919891	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr10:116919891C>T	ENST00000355044.3	+	6	1046	c.920C>T	c.(919-921)tCa>tTa	p.S307L	ATRNL1_ENST00000529665.1_3'UTR|ATRNL1_ENST00000527407.1_Missense_Mutation_p.S307L	NM_207303.2	NP_997186.1	Q5VV63	ATRN1_HUMAN	attractin-like 1	307						integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(11)|liver(2)|lung(44)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		GGTCGGGCTTCACATAAAGCA	0.368000													13	106					0	0	1	0	0
RAVER1	125950	broad.mit.edu	37	19	10439531	10439531	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr19:10439531C>T	ENST00000293677.6	-	3	675	c.594G>A	c.(592-594)atG>atA	p.M198I		NM_133452.2	NP_597709.2	Q8IY67	RAVR1_HUMAN	ribonucleoprotein, PTB-binding 1	181	RRM 2.					cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding			breast(1)|endometrium(3)|large_intestine(1)|lung(8)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	18			OV - Ovarian serous cystadenocarcinoma(20;1.81e-09)|Epithelial(33;3.65e-06)|all cancers(31;8.35e-06)			AGTCCTTCTTCATGTACTCAG	0.642000													7	32					0	0	1	0	0
PCDHB6	56130	broad.mit.edu	37	5	140532031	140532031	+	Silent	SNP	A	A	G			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr5:140532031A>G	ENST00000231136.1	+	1	2193	c.2193A>G	c.(2191-2193)ccA>ccG	p.P731P	PCDHB6_ENST00000543635.1_Silent_p.P595P	NM_018939.2	NP_061762.1	Q9Y5E3	PCDB6_HUMAN		731					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			cervix(1)|endometrium(14)|kidney(6)|large_intestine(16)|liver(1)|lung(33)|ovary(1)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	84			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GTCCCTTTCCAGGGCATCTGG	0.612000													18	211					0	0	1	0	0
ZDBF2	57683	broad.mit.edu	37	2	207173957	207173957	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr2:207173957G>C	ENST00000374423.3	+	5	5091	c.4705G>C	c.(4705-4707)Gat>Cat	p.D1569H		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	1569							nucleic acid binding|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						AGAATGTATTGATATAGAAGA	0.358000													6	17					0	0	1	0	0
UBR4	23352	broad.mit.edu	37	1	19525298	19525298	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr1:19525298G>C	ENST00000375267.2	-	4	506	c.503C>G	c.(502-504)tCa>tGa	p.S168*	UBR4_ENST00000375226.2_Nonsense_Mutation_p.S168*|UBR4_ENST00000375254.3_Nonsense_Mutation_p.S168*|UBR4_ENST00000375217.2_Nonsense_Mutation_p.S168*			Q5T4S7	UBR4_HUMAN	ubiquitin protein ligase E3 component n-recognin 4	168					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		CCCACCGTCTGAAAGTGTCTT	0.498000													33	89					0	0	1	0	0
UBR3	130507	broad.mit.edu	37	2	170938300	170938300	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr2:170938300C>G	ENST00000272793.5	+	39	5664	c.5614C>G	c.(5614-5616)Cat>Gat	p.H1872D	UBR3_ENST00000418381.1_Missense_Mutation_p.H1872D|UBR3_ENST00000392631.1_Missense_Mutation_p.H693D			Q6ZT12	UBR3_HUMAN	ubiquitin protein ligase E3 component n-recognin 3 (putative)	1872					sensory perception of smell|suckling behavior|ubiquitin-dependent protein catabolic process	integral to membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(9)|liver(1)|lung(8)|ovary(1)|prostate(3)|stomach(1)	33						GTGGATTTCTCATACTTTTGA	0.363000													7	55					0	0	1	0	0
CASP3	836	broad.mit.edu	37	4	185550591	185550591	+	Silent	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr4:185550591C>T	ENST00000308394.4	-	8	931	c.669G>A	c.(667-669)ctG>ctA	p.L223L	CASP3_ENST00000517513.1_Silent_p.*183*|CASP3_ENST00000523916.1_Silent_p.L223L|CASP3_ENST00000393585.2_Silent_p.*183*|CASP3_ENST00000393588.4_Silent_p.*183*	NM_004346.3	NP_004337.2	P42574	CASP3_HUMAN	caspase 3, apoptosis-related cysteine peptidase	223					activation of caspase activity by cytochrome c|DNA fragmentation involved in apoptotic nuclear change|negative regulation of apoptosis|nerve growth factor receptor signaling pathway|nuclear fragmentation involved in apoptotic nuclear change|proteolysis|response to tumor necrosis factor	cytosol|mitochondrion|nucleoplasm|plasma membrane	cysteine-type endopeptidase activity|protein binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|skin(1)	12		all_lung(41;7.57e-14)|Lung NSC(41;1.81e-13)|Colorectal(36;0.00139)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_neural(102;0.057)|all_hematologic(60;0.0592)		all cancers(43;2.05e-27)|Epithelial(43;4.27e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.04e-11)|Colorectal(24;2e-05)|STAD - Stomach adenocarcinoma(60;2.35e-05)|GBM - Glioblastoma multiforme(59;4.94e-05)|COAD - Colon adenocarcinoma(29;0.00017)|BRCA - Breast invasive adenocarcinoma(30;0.000218)|LUSC - Lung squamous cell carcinoma(40;0.00904)|READ - Rectum adenocarcinoma(43;0.161)	Melatonin(DB01065)|Minocycline(DB01017)|Simvastatin(DB00641)	CATACTGTTTCAGCATGGCAC	0.418000													23	49					0	0	1	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140720688	140720688	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr5:140720688G>A	ENST00000394576.2	+	1	2150	c.2150G>A	c.(2149-2151)cGg>cAg	p.R717Q	PCDHGA1_ENST00000517417.1_Intron	NM_018915.2	NP_061738.1														breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(32)|ovary(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACAGGCTGCGGCGCTGGCAC	0.647000													39	130					0	0	1	0	0
PNPLA1	285848	broad.mit.edu	37	6	36270066	36270066	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr6:36270066C>T	ENST00000394571.2	+	6	1204	c.1204C>T	c.(1204-1206)Cag>Tag	p.Q402*	PNPLA1_ENST00000312917.5_Nonsense_Mutation_p.Q316*|PNPLA1_ENST00000388715.3_Nonsense_Mutation_p.Q307*	NM_001145717.1	NP_001139189.2	Q8N8W4	PLPL1_HUMAN	patatin-like phospholipase domain containing 1	402	Pro-rich.				lipid catabolic process		hydrolase activity			breast(1)|kidney(1)|large_intestine(4)|lung(9)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)	22						TCTGTCACCTCAGCAGCAGGT	0.607000											OREG0017382	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	125					0	0	1	0	0
HRNR	388697	broad.mit.edu	37	1	152188128	152188128	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr1:152188128G>A	ENST00000368801.2	-	3	6052	c.5977C>T	c.(5977-5979)Cga>Tga	p.R1993*	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	1993					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CGAGACTCTCGGTGACCTAAG	0.572000													68	1237					0	0	1	0	0
NYNRIN	57523	broad.mit.edu	37	14	24878576	24878576	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr14:24878576C>T	ENST00000382554.3	+	4	1894	c.1576C>T	c.(1576-1578)Caa>Taa	p.Q526*		NM_025081.2	NP_079357.2	Q9P2P1	NYNRI_HUMAN	NYN domain and retroviral integrase containing	526					DNA integration	integral to membrane	DNA binding			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(8)|lung(21)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	56						GCCCGTGGCTCAAGGGGGGCT	0.567000													9	82					0	0	1	0	0
MAPKBP1	23005	broad.mit.edu	37	15	42116199	42116199	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr15:42116199G>A	ENST00000457542.2	+	29	4439	c.4153G>A	c.(4153-4155)Gag>Aag	p.E1385K	MAPKBP1_ENST00000260357.7_Missense_Mutation_p.E1224K|MAPKBP1_ENST00000221214.6_Missense_Mutation_p.E1268K|MAPKBP1_ENST00000514566.1_Intron|MAPKBP1_ENST00000456763.2_Missense_Mutation_p.E1391K	NM_014994.2	NP_055809.2	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein 1	1391								p.E1385K(1)		breast(6)|central_nervous_system(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	56		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		CCCACCCCCTGAGAAGACTCC	0.637000													11	229					0	0	1	0	0
KCNK15	60598	broad.mit.edu	37	20	43378877	43378877	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr20:43378877C>T	ENST00000372861.3	+	2	522	c.391C>T	c.(391-393)Cgg>Tgg	p.R131W		NM_022358.3	NP_071753.2	Q9H427	KCNKF_HUMAN	potassium channel, subfamily K, member 15	131						integral to membrane	potassium channel activity|voltage-gated ion channel activity			NS(1)|endometrium(1)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(2)	10		Myeloproliferative disorder(115;0.0122)				CCTGGGCGAACGGCTGAACGC	0.692000													12	25					0	0	1	0	0
DAAM1	23002	broad.mit.edu	37	14	59757989	59757989	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr14:59757989G>A	ENST00000395125.1	+	2	261	c.238G>A	c.(238-240)Gag>Aag	p.E80K	DAAM1_ENST00000360909.3_Missense_Mutation_p.E80K|DAAM1_ENST00000556135.1_Missense_Mutation_p.E80K|DAAM1_ENST00000351081.1_Missense_Mutation_p.E80K	NM_014992.2	NP_055807.1	Q9Y4D1	DAAM1_HUMAN	dishevelled associated activator of morphogenesis 1	80	GBD/FH3.				actin cytoskeleton organization	cytoplasm|plasma membrane	actin binding|Rho GTPase binding			breast(3)|cervix(3)|endometrium(5)|kidney(5)|large_intestine(4)|lung(7)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	37				OV - Ovarian serous cystadenocarcinoma(108;0.165)		ACTTCCAGCTGAGAAAAAATG	0.333000													14	27					0	0	1	0	0
ARMC6	93436	broad.mit.edu	37	19	19165128	19165128	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr19:19165128C>T	ENST00000535612.1	+	6	1453	c.1021C>T	c.(1021-1023)Cag>Tag	p.Q341*	ARMC6_ENST00000546344.1_Nonsense_Mutation_p.Q248*|ARMC6_ENST00000392336.3_Nonsense_Mutation_p.Q341*|ARMC6_ENST00000392335.2_Nonsense_Mutation_p.Q316*|ARMC6_ENST00000269932.6_Nonsense_Mutation_p.Q316*	NM_001199196.1	NP_001186125.1	Q6NXE6	ARMC6_HUMAN	armadillo repeat containing 6	341							protein binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|liver(2)|lung(5)|ovary(1)|prostate(1)	14			OV - Ovarian serous cystadenocarcinoma(5;5.66e-06)|Epithelial(12;0.000391)			GAGCGGCGTTCAGGTATGAAG	0.617000											OREG0025376	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	65					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168119691	168119691	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr5:168119691C>G	ENST00000519560.1	-	29	3516	c.3097G>C	c.(3097-3099)Gag>Cag	p.E1033Q	SLIT3_ENST00000404867.3_Missense_Mutation_p.E1033Q|SLIT3_ENST00000332966.8_Missense_Mutation_p.E1040Q	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	1033					apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCAATCACCTCGTCGCATAGC	0.577000													10	38					0	0	1	0	0
ZNF213	7760	broad.mit.edu	37	16	3188497	3188497	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr16:3188497G>A	ENST00000396878.3	+	3	953	c.478G>A	c.(478-480)Gca>Aca	p.A160T	ZNF213_ENST00000576416.1_Missense_Mutation_p.A160T|ZNF213_ENST00000416391.2_Silent_p.G26G|ZNF213_ENST00000574902.1_Missense_Mutation_p.A160T	NM_001134655.1|NM_004220.2	NP_001128127.1|NP_004211.1	O14771	ZN213_HUMAN	zinc finger protein 213	160					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)	16						GACGGTGGGGGCACGGAGGCG	0.677000													9	61					0	0	1	0	0
AGAP3	116988	broad.mit.edu	37	7	150817139	150817139	+	Silent	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr7:150817139C>T	ENST00000397238.2	+	8	1035	c.1035C>T	c.(1033-1035)atC>atT	p.I345I	AGAP3_ENST00000473312.1_Silent_p.I345I|AGAP3_ENST00000335367.3_Silent_p.I525I|AGAP3_ENST00000463381.1_Silent_p.I117I|AGAP3_ENST00000479901.1_Intron	NM_031946.4	NP_114152.3	Q96P47	AGAP3_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 3	309	Small GTPase-like.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm|membrane	ARF GTPase activator activity|GTP binding|GTPase activity|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(3)|liver(2)|lung(9)|ovary(2)|prostate(3)|urinary_tract(1)	28						CCCCCAGCATCAGCCAGCGGG	0.652000													16	74					0	0	1	0	0
OR2A2	442361	broad.mit.edu	37	7	143807504	143807504	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr7:143807504C>T	ENST00000408979.2	+	1	898	c.829C>T	c.(829-831)Cac>Tac	p.H277Y		NM_001005480.2	NP_001005480.2	Q6IF42	OR2A2_HUMAN	olfactory receptor, family 2, subfamily A, member 2	277					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(13)|prostate(1)|skin(4)	22	Melanoma(164;0.0783)					GTCCCTGTTTCACAGTGTCTT	0.507000													21	204					0	0	1	0	0
HELZ	9931	broad.mit.edu	37	17	65103405	65103405	+	Missense_Mutation	SNP	G	G	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr17:65103405G>T	ENST00000358691.5	-	31	5287	c.5121C>A	c.(5119-5121)caC>caA	p.H1707Q	HELZ_ENST00000580168.1_Missense_Mutation_p.H1708Q	NM_014877.3	NP_055692.2			helicase with zinc finger											NS(1)|breast(5)|endometrium(9)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					GCGGTGGCCTGTGAGGCAATG	0.458000													31	173					1.80694e-10	1.92305e-10	1	1	0
LRRC4C	57689	broad.mit.edu	37	11	40137376	40137376	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr11:40137376C>T	ENST00000278198.2	-	2	2430	c.467G>A	c.(466-468)cGa>cAa	p.R156Q	LRRC4C_ENST00000527150.1_Missense_Mutation_p.R156Q|LRRC4C_ENST00000530763.1_Missense_Mutation_p.R156Q|LRRC4C_ENST00000528697.1_Missense_Mutation_p.R156Q			Q9HCJ2	LRC4C_HUMAN	leucine rich repeat containing 4C	156					regulation of axonogenesis	integral to membrane	protein binding	p.R156Q(2)		NS(2)|central_nervous_system(3)|endometrium(1)|large_intestine(14)|lung(43)|ovary(5)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	86		all_lung(304;0.0575)|Lung NSC(402;0.138)				GGGGTTGTTTCGCAACCAGAG	0.428000													8	70					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126411726	126411726	+	Silent	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr4:126411726C>T	ENST00000394329.3	+	17	13762	c.13749C>T	c.(13747-13749)atC>atT	p.I4583I	FAT4_ENST00000335110.5_Silent_p.I2824I	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	4583					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						AACCAGATATCATTGAAAGGG	0.478000													13	71					0	0	1	0	0
MFNG	4242	broad.mit.edu	37	22	37882050	37882050	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr22:37882050C>T	ENST00000356998.3	-	1	389	c.166G>A	c.(166-168)Gtc>Atc	p.V56I	MFNG_ENST00000416983.3_Missense_Mutation_p.V56I	NM_002405.3	NP_002396.2	O00587	MFNG_HUMAN	MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	56					pattern specification process	extracellular space|integral to Golgi membrane	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity			large_intestine(2)|lung(2)|skin(1)	5	Melanoma(58;0.0574)					GCAATGAAGACATCGTGTAGC	0.622000													19	63					0	0	1	0	0
YIPF7	285525	broad.mit.edu	37	4	44626764	44626764	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr4:44626764C>T	ENST00000332990.5	-	5	550	c.534G>A	c.(532-534)atG>atA	p.M178I		NM_182592.2	NP_872398.2	Q8N8F6	YIPF7_HUMAN	Yip1 domain family, member 7	178						endoplasmic reticulum membrane|integral to membrane				breast(1)|large_intestine(1)|lung(9)|upper_aerodigestive_tract(1)	12						CAATGGCACTCATGCCATACA	0.493000													4	16					0	0	1	0	0
VPS18	57617	broad.mit.edu	37	15	41193186	41193186	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr15:41193186G>A	ENST00000220509.5	+	4	2509	c.2170G>A	c.(2170-2172)Gag>Aag	p.E724K	VPS18_ENST00000558474.1_Intron	NM_020857.2	NP_065908.1	Q9P253	VPS18_HUMAN	vacuolar protein sorting 18 homolog (S. cerevisiae)	724					endosome organization|lysosome organization|protein transport	HOPS complex|late endosome membrane|lysosomal membrane	metal ion binding|protein binding			autonomic_ganglia(1)|endometrium(5)|kidney(4)|large_intestine(4)|lung(6)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	28		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;1.07e-05)|COAD - Colon adenocarcinoma(120;0.15)|BRCA - Breast invasive adenocarcinoma(123;0.164)		AGAGCTGTATGAGGAGGCCGT	0.602000													25	54					0	0	1	0	0
MATN4	8785	broad.mit.edu	37	20	43933166	43933166	+	Silent	SNP	C	C	G			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr20:43933166C>G	ENST00000537548.1	-	4	589	c.345G>C	c.(343-345)ctG>ctC	p.L115L	MATN4_ENST00000372754.1_Silent_p.L115L|MATN4_ENST00000372753.1_Intron|MATN4_ENST00000353917.5_Silent_p.L115L|MATN4_ENST00000372756.1_Silent_p.L115L|MATN4_ENST00000372751.4_Intron|MATN4_ENST00000342716.4_Silent_p.L115L|MATN4_ENST00000360607.5_Silent_p.L115L			O95460	MATN4_HUMAN	matrilin 4	115	VWFA 1.					extracellular region	protein binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	27		Myeloproliferative disorder(115;0.0122)				ACTGGATTGCCAGTCCCGTCA	0.682000													10	23					0	0	1	0	0
TIE1	7075	broad.mit.edu	37	1	43770753	43770753	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr1:43770753C>G	ENST00000372476.3	+	2	369	c.290C>G	c.(289-291)tCg>tGg	p.S97W	TIE1_ENST00000538015.1_Missense_Mutation_p.S97W|TIE1_ENST00000441333.2_Missense_Mutation_p.S97W	NM_001253357.1|NM_005424.4	NP_001240286.1|NP_005415.1	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	97	Ig-like C2-type 1.				mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(8)|lung(28)|ovary(3)|prostate(2)|salivary_gland(1)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	70	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TCCAAGCCCTCGGACCTCGTG	0.706000													15	21					0	0	1	0	0
FBXO18	84893	broad.mit.edu	37	10	5948426	5948426	+	Nonsense_Mutation	SNP	C	C	G			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr10:5948426C>G	ENST00000379999.5	+	4	841	c.737C>G	c.(736-738)tCa>tGa	p.S246*	FBXO18_ENST00000397269.3_5'UTR|FBXO18_ENST00000470089.1_3'UTR|FBXO18_ENST00000362091.4_Nonsense_Mutation_p.S195*	NM_032807.4	NP_116196.3	Q8NFZ0	FBX18_HUMAN	F-box protein, helicase, 18	195					DNA repair	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|breast(2)|kidney(2)|large_intestine(16)|lung(9)|ovary(2)|prostate(3)|skin(3)|stomach(1)	40						ATTCCTGACTCATACTATGGG	0.587000													12	34					0	0	1	0	0
NLRP3	114548	broad.mit.edu	37	1	247582139	247582139	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr1:247582139G>C	ENST00000366497.2	+	2	823	c.43G>C	c.(43-45)Gag>Cag	p.E15Q	NLRP3_ENST00000391828.3_Missense_Mutation_p.E15Q|NLRP3_ENST00000391827.2_Missense_Mutation_p.E15Q|NLRP3_ENST00000336119.3_Missense_Mutation_p.E15Q|NLRP3_ENST00000474792.1_3'UTR|NLRP3_ENST00000366496.2_Missense_Mutation_p.E15Q|NLRP3_ENST00000348069.2_Missense_Mutation_p.E15Q	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	15	DAPIN.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			CAGGTACCTGGAGGACCTGGA	0.542000													7	81					0	0	1	0	0
RGMA	56963	broad.mit.edu	37	15	93588297	93588297	+	Silent	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr15:93588297C>T	ENST00000329082.7	-	4	1555	c.1284G>A	c.(1282-1284)ctG>ctA	p.L428L	RGMA_ENST00000538818.1_Silent_p.L319L|RGMA_ENST00000543599.1_Silent_p.L412L|RGMA_ENST00000556658.1_Silent_p.L319L|RGMA_ENST00000425933.2_Silent_p.L412L|RGMA_ENST00000557301.1_Silent_p.L436L|RGMA_ENST00000542321.2_Silent_p.L412L|RGMA_ENST00000557420.1_3'UTR	NM_020211.2	NP_064596.2	Q96B86	RGMA_HUMAN	repulsive guidance molecule family member a	428					axon guidance	anchored to membrane|endoplasmic reticulum|plasma membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(2)|prostate(1)	9	Lung NSC(78;0.0542)|all_lung(78;0.0786)		BRCA - Breast invasive adenocarcinoma(143;0.0312)|OV - Ovarian serous cystadenocarcinoma(32;0.108)			GGGCCAGGGGCAGCCCCGCAG	0.667000													3	10					0	0	1	0	0
TMEM51	55092	broad.mit.edu	37	1	15541866	15541866	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr1:15541866G>T	ENST00000428417.1	+	2	729	c.283G>T	c.(283-285)Gag>Tag	p.E95*	TMEM51_ENST00000400796.3_Nonsense_Mutation_p.E95*|TMEM51_ENST00000376014.3_Nonsense_Mutation_p.E95*|TMEM51_ENST00000376008.2_Nonsense_Mutation_p.E95*|TMEM51_ENST00000434578.2_Nonsense_Mutation_p.E95*	NM_001136217.1	NP_001129689.1	Q9NW97	TMM51_HUMAN	transmembrane protein 51	95						integral to membrane				breast(1)|central_nervous_system(1)|cervix(3)|large_intestine(2)|lung(5)|prostate(2)	14		Renal(390;0.00145)|Breast(348;0.00186)|Colorectal(325;0.00215)|all_lung(284;0.00459)|Lung NSC(340;0.0104)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;2.07e-06)|COAD - Colon adenocarcinoma(227;7.14e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000175)|KIRC - Kidney renal clear cell carcinoma(229;0.00141)|STAD - Stomach adenocarcinoma(313;0.00644)|READ - Rectum adenocarcinoma(331;0.0751)		GCGGCAGGGCGAGGACCTGGC	0.652000													16	38					3.32936e-07	3.50111e-07	1	1	0
ALOX5	240	broad.mit.edu	37	10	45941106	45941106	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr10:45941106G>C	ENST00000374391.2	+	14	2049	c.1996G>C	c.(1996-1998)Gac>Cac	p.D666H	ALOX5_ENST00000542434.1_Missense_Mutation_p.D609H|RP11-67C2.2_ENST00000435635.1_RNA	NM_000698.3|NM_001256153.1	NP_000689.1|NP_001243082.1	P09917	LOX5_HUMAN	arachidonate 5-lipoxygenase	666	Lipoxygenase.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process	cytosol|nuclear envelope lumen|nuclear matrix|nuclear membrane	arachidonate 5-lipoxygenase activity|iron ion binding|lipoxygenase activity|protein binding			breast(1)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(14)|ovary(2)|pancreas(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	37		Lung SC(717;0.0257)			Diethylcarbamazine(DB00711)|Hydrocortisone(DB00741)|Leflunomide(DB01097)|Masoprocol(DB00179)|Meclofenamic acid(DB00939)|Minocycline(DB01017)|Montelukast(DB00471)|Quinacrine(DB01103)|Vitamin E(DB00163)|Zileuton(DB00744)	CTTGTCCCCAGACCGGATTCC	0.587000													14	123					0	0	1	0	0
ZNF454	285676	broad.mit.edu	37	5	178369801	178369801	+	Silent	SNP	C	C	G			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr5:178369801C>G	ENST00000320129.3	+	2	312	c.9C>G	c.(7-9)gtC>gtG	p.V3V	ZNF454_ENST00000519564.1_Silent_p.V3V	NM_001178090.1|NM_182594.2	NP_001171561.1|NP_872400.2	Q8N9F8	ZN454_HUMAN	zinc finger protein 454	3					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(11)|lung(18)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)	46	all_cancers(89;0.000904)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.225)|all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.234)		GAATGGCTGTCAGCCACCTGC	0.537000													10	52					0	0	1	0	0
EPHA2	1969	broad.mit.edu	37	1	16456780	16456780	+	Silent	SNP	G	G	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr1:16456780G>A	ENST00000358432.5	-	15	2764	c.2610C>T	c.(2608-2610)atC>atT	p.I870I		NM_004431.3	NP_004422.2	P29317	EPHA2_HUMAN	EPH receptor A2	870	Mediates interaction with ARHGEF16 and ELMO2.|Protein kinase.				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	42		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	GCTTGTCCAGGATGCTGACGA	0.602000													12	74					0	0	1	0	0
ZBTB49	166793	broad.mit.edu	37	4	4322525	4322525	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr4:4322525G>C	ENST00000337872.4	+	8	1901	c.1780G>C	c.(1780-1782)Gat>Cat	p.D594H	ZBTB49_ENST00000355834.3_Missense_Mutation_p.D472H|ZBTB49_ENST00000538529.1_Missense_Mutation_p.D77H	NM_145291.3	NP_660334.3	Q6ZSB9	ZBT49_HUMAN	zinc finger and BTB domain containing 49	594					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|kidney(3)|large_intestine(5)|lung(9)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	28						CGAGAGCCCAGATGTGCTGGA	0.562000													9	54					0	0	1	0	0
PIK3C2G	5288	broad.mit.edu	37	12	18658283	18658283	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr12:18658283G>C	ENST00000433979.1	+	23	3204	c.3088G>C	c.(3088-3090)Gga>Cga	p.G1030R	PIK3C2G_ENST00000538779.1_Missense_Mutation_p.G1071R|PIK3C2G_ENST00000266497.5_Missense_Mutation_p.G1030R	NM_004570.4	NP_004561.3	O75747	P3C2G_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma	1030	PI3K/PI4K.				cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			breast(5)|central_nervous_system(6)|endometrium(2)|kidney(4)|large_intestine(8)|lung(31)|ovary(2)|prostate(1)|skin(2)|stomach(4)|upper_aerodigestive_tract(1)	66		Hepatocellular(102;0.194)				ATTCATCCTGGGAGTATGTGA	0.383000													5	21					0	0	1	0	0
CLASP2	23122	broad.mit.edu	37	3	33661222	33661222	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr3:33661222G>A	ENST00000399362.4	-	12	1543	c.1190C>T	c.(1189-1191)tCa>tTa	p.S397L	CLASP2_ENST00000461133.3_Missense_Mutation_p.S164L|CLASP2_ENST00000333778.6_Missense_Mutation_p.S174L|CLASP2_ENST00000313350.6_Missense_Mutation_p.S170L|CLASP2_ENST00000359576.5_Missense_Mutation_p.S397L|CLASP2_ENST00000480013.1_Missense_Mutation_p.S164L|CLASP2_ENST00000487200.1_Missense_Mutation_p.S170L|CLASP2_ENST00000307312.7_5'UTR|CLASP2_ENST00000468888.2_Missense_Mutation_p.S398L|CLASP2_ENST00000539981.1_Missense_Mutation_p.S149L	NM_015097.2	NP_055912.2	B2RTR1	B2RTR1_HUMAN	cytoplasmic linker associated protein 2	398										breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(19)|ovary(3)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	48						CAAAACTGTTGAAAGGTGGCT	0.323000													3	8					0	0	1	0	0
VSIG10	54621	broad.mit.edu	37	12	118520021	118520021	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr12:118520021G>A	ENST00000359236.5	-	3	851	c.575C>T	c.(574-576)tCg>tTg	p.S192L		NM_019086.5	NP_061959.2	Q8N0Z9	VSI10_HUMAN	V-set and immunoglobulin domain containing 10	192	Ig-like C2-type 2.					integral to membrane				endometrium(5)|large_intestine(3)|lung(6)|skin(1)|stomach(1)|urinary_tract(1)	17						GAGGTTTGGCGATATCAGTAA	0.517000													19	110					0	0	1	0	0
CDCP1	64866	broad.mit.edu	37	3	45127156	45127156	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr3:45127156G>C	ENST00000296129.1	-	9	2619	c.2485C>G	c.(2485-2487)Cag>Gag	p.Q829E		NM_022842.3	NP_073753.3	Q9H5V8	CDCP1_HUMAN	CUB domain containing protein 1	829						extracellular region|integral to membrane|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|skin(4)|urinary_tract(1)	29				BRCA - Breast invasive adenocarcinoma(193;0.00928)|KIRC - Kidney renal clear cell carcinoma(197;0.0519)|Kidney(197;0.0651)		ATGGGCTCCTGAGTGTTCAGT	0.522000													27	106					0	0	1	0	0
RNF148	378925	broad.mit.edu	37	7	122342732	122342732	+	Silent	SNP	G	G	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr7:122342732G>A	ENST00000434824.1	-	1	289	c.73C>T	c.(73-75)Cta>Tta	p.L25L	CADPS2_ENST00000412584.2_Intron|RNF148_ENST00000447240.1_Silent_p.L25L|CADPS2_ENST00000449022.2_Intron|CADPS2_ENST00000334010.7_Intron|CADPS2_ENST00000313070.7_Intron	NM_198085.1	NP_932351.1	Q8N7C7	RN148_HUMAN	ring finger protein 148	25						integral to membrane	zinc ion binding			endometrium(2)|kidney(1)|large_intestine(6)|lung(7)	16						CTAAGTAGTAGAAAGATACTA	0.403000													5	22					0	0	1	0	0
ATF7	11016	broad.mit.edu	37	12	53911088	53911088	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr12:53911088G>A	ENST00000420353.2	-	12	1434	c.1285C>T	c.(1285-1287)Cag>Tag	p.Q429*	RP11-793H13.3_ENST00000548347.1_RNA|ATF7_ENST00000456903.4_Nonsense_Mutation_p.Q429*|ATF7_ENST00000328463.7_Nonsense_Mutation_p.Q440*|ATF7_ENST00000546661.1_5'UTR|RP11-793H13.10_ENST00000591834.1_Intron|ATF7_ENST00000415113.1_Nonsense_Mutation_p.Q408*|ATF7_ENST00000548446.2_Nonsense_Mutation_p.Q440*	NM_006856.2	NP_006847.1	P17544	ATF7_HUMAN	activating transcription factor 7	440	Essential for binding adenovirus 2 E1A.				interspecies interaction between organisms	cytoplasm|nuclear periphery|nucleoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)|skin(1)|urinary_tract(1)	9						GAGCTGTGCTGAATCACAGGG	0.562000													9	34					0	0	1	0	0
MAST3	23031	broad.mit.edu	37	19	18255834	18255834	+	Missense_Mutation	SNP	T	T	C			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr19:18255834T>C	ENST00000262811.5	+	23	2747	c.2747T>C	c.(2746-2748)cTc>cCc	p.L916P	AC007192.6_ENST00000600364.1_RNA	NM_015016.1	NP_055831.1	O60307	MAST3_HUMAN	microtubule associated serine/threonine kinase 3	916	Ser-rich.						ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(6)|ovary(4)|pancreas(1)|stomach(1)	31						GGCGGCCCCCTCATGAGCCCC	0.692000													10	41					0	0	1	0	0
SCN4A	6329	broad.mit.edu	37	17	62022765	62022765	+	Silent	SNP	G	G	C			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr17:62022765G>C	ENST00000578147.1	-	19	3751	c.3675C>G	c.(3673-3675)gtC>gtG	p.V1225V	SCN4A_ENST00000435607.1_Silent_p.V1225V			P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	1225					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	TGTCGTAGTTGACCTTGACAT	0.617000													63	93					0	0	1	0	0
PHIP	55023	broad.mit.edu	37	6	79656513	79656513	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr6:79656513G>C	ENST00000275034.4	-	37	4452	c.4285C>G	c.(4285-4287)Ctt>Gtt	p.L1429V	PHIP_ENST00000479165.1_5'UTR	NM_017934.5	NP_060404.3	Q8WWQ0	PHIP_HUMAN	pleckstrin homology domain interacting protein	1429					insulin receptor signaling pathway|negative regulation of apoptosis|positive regulation of cell proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis	nucleus	insulin receptor binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(10)|kidney(4)|large_intestine(20)|lung(20)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	68		all_cancers(76;0.00125)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.219)		BRCA - Breast invasive adenocarcinoma(397;0.231)		TGAAAACGAAGAGCAGATTTA	0.348000													6	49					0	0	1	0	0
KRT83	3889	broad.mit.edu	37	12	52711548	52711548	+	Missense_Mutation	SNP	C	C	T	rs149581248		TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr12:52711548C>T	ENST00000293670.3	-	4	729	c.667G>A	c.(667-669)Gcc>Acc	p.A223T		NM_002282.3	NP_002273.3	P78385	KRT83_HUMAN	keratin 83	223	Coil 1B.|Rod.				epidermis development	keratin filament	structural molecule activity			NS(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(9)|prostate(1)|skin(4)|stomach(7)|upper_aerodigestive_tract(1)	32	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)		CGGAGGTAGGCGCAGTCCACA	0.627000													30	122					0	0	1	0	0
CEP350	9857	broad.mit.edu	37	1	180031466	180031466	+	Missense_Mutation	SNP	C	C	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr1:180031466C>A	ENST00000367607.3	+	26	5792	c.5374C>A	c.(5374-5376)Cag>Aag	p.Q1792K		NM_014810.4	NP_055625.4	Q5VT06	CE350_HUMAN	centrosomal protein 350kDa	1792						centrosome|nucleus|spindle				central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	66						CATAAAACTACAGGAGAAATT	0.403000													3	17					0.115264	0.115701	1	1	0
KRT12	3859	broad.mit.edu	37	17	39021192	39021192	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr17:39021192G>A	ENST00000251643.4	-	3	696	c.673C>T	c.(673-675)Cgc>Tgc	p.R225C		NM_000223.3	NP_000214.1	Q99456	K1C12_HUMAN	keratin 12	225	Coil 1B.|Rod.				visual perception	intermediate filament	structural molecule activity	p.R225C(2)		central_nervous_system(1)|endometrium(1)|large_intestine(3)|liver(1)|lung(5)|ovary(2)|upper_aerodigestive_tract(2)	15		Breast(137;0.000301)				ACGCCCTGGCGCAGGGCCAGT	0.552000													15	67					0	0	1	0	0
CCDC135	84229	broad.mit.edu	37	16	57760012	57760012	+	Silent	SNP	G	G	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr16:57760012G>A	ENST00000360716.3	+	14	2012	c.1791G>A	c.(1789-1791)gcG>gcA	p.A597A	CCDC135_ENST00000336825.8_Silent_p.A532A|CCDC135_ENST00000394337.4_Silent_p.A597A			Q8IY82	CC135_HUMAN	coiled-coil domain containing 135	597						cytoplasm				breast(1)|central_nervous_system(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	30						GCAACCCAGCGAAGCCCGCGG	0.602000													7	23					0	0	1	0	0
MLKL	197259	broad.mit.edu	37	16	74729454	74729454	+	Missense_Mutation	SNP	C	C	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr16:74729454C>A	ENST00000308807.7	-	2	665	c.202G>T	c.(202-204)Gcc>Tcc	p.A68S	MLKL_ENST00000306247.7_Missense_Mutation_p.A68S	NM_152649.2	NP_689862.1	Q8NB16	MLKL_HUMAN	mixed lineage kinase domain-like	68							ATP binding|protein binding|protein kinase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(2)|lung(6)|skin(1)|stomach(2)	19						TCCTCCAGGGCAGCCTTGAAG	0.512000													8	59					1.12685e-05	1.17565e-05	1	1	0
RNF216	54476	broad.mit.edu	37	7	5800679	5800679	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr7:5800679C>T	ENST00000425013.2	-	2	246	c.22G>A	c.(22-24)Gaa>Aaa	p.E8K	RNF216_ENST00000389902.3_Missense_Mutation_p.E8K	NM_207111.3|NM_207116.2	NP_996994.1|NP_996999.1	Q9NWF9	RN216_HUMAN	ring finger protein 216	8					apoptosis|interspecies interaction between organisms|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination|regulation of defense response to virus by host|regulation of interferon-beta production	cytoplasm|nucleus	ligase activity|protein binding|zinc ion binding		FBXL18/RNF216(2)	breast(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(11)|ovary(3)|prostate(1)|skin(1)|urinary_tract(4)	33		Ovarian(82;0.07)		UCEC - Uterine corpus endometrioid carcinoma (126;0.135)|OV - Ovarian serous cystadenocarcinoma(56;2.69e-13)		ATTACCTCTTCATTGTTGTTT	0.388000													8	48					0	0	1	0	0
NAA15	80155	broad.mit.edu	37	4	140270652	140270652	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr4:140270652C>T	ENST00000296543.5	+	7	1051	c.728C>T	c.(727-729)gCt>gTt	p.A243V	NAA15_ENST00000480277.2_3'UTR|NAA15_ENST00000398947.1_Missense_Mutation_p.A243V	NM_057175.3	NP_476516.1	Q9BXJ9	NAA15_HUMAN	N(alpha)-acetyltransferase 15, NatA auxiliary subunit	243					angiogenesis|cell differentiation|N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|transcription factor complex	protein binding			NS(1)|endometrium(3)|large_intestine(7)|liver(2)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	29						TTGGAAGATGCTGCAGATGTT	0.338000													4	18					0	0	1	0	0
ITGB4	3691	broad.mit.edu	37	17	73729698	73729698	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr17:73729698G>A	ENST00000200181.3	+	13	1769	c.1582G>A	c.(1582-1584)Gaa>Aaa	p.E528K	ITGB4_ENST00000450894.3_Missense_Mutation_p.E528K|ITGB4_ENST00000449880.2_Missense_Mutation_p.E528K|ITGB4_ENST00000579662.1_Missense_Mutation_p.E528K|ITGB4_ENST00000584558.1_3'UTR|ITGB4_ENST00000339591.3_Missense_Mutation_p.E528K	NM_000213.3	NP_000204.3	P16144	ITB4_HUMAN	integrin, beta 4	528	Cysteine-rich tandem repeats.				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|liver(1)|lung(25)|skin(1)|urinary_tract(1)	43	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			GTGCTACGGCGAAGGCCGCTA	0.632000													24	90					0	0	1	0	0
CRYGS	1427	broad.mit.edu	37	3	186256703	186256703	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr3:186256703G>C	ENST00000392499.2	-	4	658	c.319C>G	c.(319-321)Cag>Gag	p.Q107E	CRYGS_ENST00000307944.5_Missense_Mutation_p.Q107E	NM_017541.2	NP_060011.1	P22914	CRBS_HUMAN	crystallin, gamma S	107	Beta/gamma crystallin 'Greek key' 3.						structural constituent of eye lens			endometrium(1)|kidney(2)|large_intestine(2)|lung(3)|prostate(1)|upper_aerodigestive_tract(2)	11	all_cancers(143;3.75e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.5e-22)	GBM - Glioblastoma multiforme(93;0.0906)		TCATACATCTGACCACTAAAA	0.433000													7	35					0	0	1	0	0
LAMC1	3915	broad.mit.edu	37	1	183091075	183091075	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr1:183091075G>C	ENST00000258341.4	+	12	2465	c.2208G>C	c.(2206-2208)gaG>gaC	p.E736D		NM_002293.3	NP_002284.3	P11047	LAMC1_HUMAN	laminin, gamma 1 (formerly LAMB2)	736	Laminin EGF-like 6.				axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent			NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(27)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	76					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GTGATCCTGAGACAGGTGAGA	0.438000													14	29					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70331681	70331681	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr11:70331681C>T	ENST00000338508.4	-	32	4719	c.4720G>A	c.(4720-4722)Gat>Aat	p.D1574N	SHANK2_ENST00000409161.1_Missense_Mutation_p.D977N|SHANK2_ENST00000423696.2_Missense_Mutation_p.D1194N|SHANK2_ENST00000449833.2_Missense_Mutation_p.D978N			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	1194					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding	p.D978H(1)|p.D1574H(1)		NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			ACAAAGCTATCTACATCTTCT	0.562000													129	1061					0	0	1	0	0
PHIP	55023	broad.mit.edu	37	6	79650558	79650558	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr6:79650558C>T	ENST00000275034.4	-	40	5485	c.5318G>A	c.(5317-5319)cGa>cAa	p.R1773Q	PHIP_ENST00000479165.1_5'UTR	NM_017934.5	NP_060404.3	Q8WWQ0	PHIP_HUMAN	pleckstrin homology domain interacting protein	1773					insulin receptor signaling pathway|negative regulation of apoptosis|positive regulation of cell proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis	nucleus	insulin receptor binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(10)|kidney(4)|large_intestine(20)|lung(20)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	68		all_cancers(76;0.00125)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.219)		BRCA - Breast invasive adenocarcinoma(397;0.231)		AGCTGTCCTTCGACCTTGATT	0.413000													13	85					0	0	1	0	0
ATP6V1F	9296	broad.mit.edu	37	7	128503037	128503037	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr7:128503037G>A	ENST00000492758.1	+	1	80	c.79G>A	c.(79-81)Gag>Aag	p.E27K	ATP6V1F_ENST00000249289.4_Missense_Mutation_p.E27K	NM_001198909.1	NP_001185838.1	Q16864	VATF_HUMAN	ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F	27					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|membrane fraction|proton-transporting V-type ATPase, V1 domain|vacuolar proton-transporting V-type ATPase complex	ATPase activity, uncoupled|hydrogen ion transporting ATP synthase activity, rotational mechanism|protein binding|proton-transporting ATPase activity, rotational mechanism			lung(1)|ovary(1)|prostate(1)	3						CGGCATAGGGGAGCTTAACAA	0.587000											OREG0018299	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	27	76					0	0	1	0	0
PPFIA1	8500	broad.mit.edu	37	11	70200478	70200478	+	Silent	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr11:70200478C>T	ENST00000253925.7	+	17	2450	c.2235C>T	c.(2233-2235)tcC>tcT	p.S745S	PPFIA1_ENST00000389547.3_Silent_p.S745S|AP000487.6_ENST00000528607.1_RNA	NM_003626.3	NP_003617.1	Q13136	LIPA1_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1	745					cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			breast(3)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	65			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			CGCCTTCCTCCCCGAGAGCCC	0.562000													9	416					0	0	1	0	0
CXorf48	54967	broad.mit.edu	37	X	134292163	134292163	+	Silent	SNP	T	T	C			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chrX:134292163T>C	ENST00000344129.2	-	4	724	c.498A>G	c.(496-498)gcA>gcG	p.A166A	CXorf48_ENST00000276241.6_Silent_p.A166A	NM_017863.2	NP_060333.1	Q8WUE5	CX048_HUMAN	chromosome X open reading frame 48	166										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(3)	5	Acute lymphoblastic leukemia(192;0.000127)					TCACAGAAGTTGCCTTGATGT	0.418000													15	32					0	0	1	0	0
KIAA0430	9665	broad.mit.edu	37	16	15692843	15692843	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr16:15692843C>T	ENST00000396368.3	-	26	5058	c.4852G>A	c.(4852-4854)Gac>Aac	p.D1618N	KIAA0430_ENST00000551742.1_Missense_Mutation_p.D1618N|KIAA0430_ENST00000602337.1_Missense_Mutation_p.D1615N|KIAA0430_ENST00000540441.2_Missense_Mutation_p.D1453N|KIAA0430_ENST00000344181.3_Missense_Mutation_p.D1306N|KIAA0430_ENST00000548025.1_Missense_Mutation_p.D1615N	NM_001184998.1|NM_001184999.1|NM_014647.3	NP_001171927.1|NP_001171928.1|NP_055462.2	Q9Y4F3	LKAP_HUMAN	KIAA0430	1617						peroxisome	nucleotide binding|RNA binding			breast(4)|endometrium(8)|kidney(4)|large_intestine(2)|lung(13)|ovary(3)|prostate(5)|skin(1)	40						GGGGAGTCGTCGGTCAGGCGG	0.652000													14	47					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179433158	179433158	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr2:179433158C>T	ENST00000589042.1	-	326	77925	c.77701G>A	c.(77701-77703)Gat>Aat	p.D25901N	TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.D24260N|TTN_ENST00000359218.5_Missense_Mutation_p.D16961N|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.D17028N|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.D16836N|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.D23333N|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000419746.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	24260	Fibronectin type-III 88.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGACGTCATCAAATTTAACA	0.393000													9	36					0	0	1	0	0
HEG1	57493	broad.mit.edu	37	3	124746348	124746348	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr3:124746348G>A	ENST00000311127.4	-	3	681	c.614C>T	c.(613-615)tCa>tTa	p.S205L		NM_020733.1	NP_065784.1	Q9ULI3	HEG1_HUMAN	heart development protein with EGF-like domains 1	205						extracellular region|integral to membrane	calcium ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(24)|ovary(2)|urinary_tract(4)	47						AAGACTTTCTGAGGCTGAAAA	0.423000													12	29					0	0	1	0	0
LAMA1	284217	broad.mit.edu	37	18	7012122	7012122	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr18:7012122G>A	ENST00000389658.3	-	24	3472	c.3379C>T	c.(3379-3381)Cct>Tct	p.P1127S		NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1	1127	Laminin EGF-like 13.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TTGCACTGAGGACCAAAGACA	0.517000													19	21					0	0	1	0	0
KIAA1524	57650	broad.mit.edu	37	3	108278852	108278852	+	Silent	SNP	C	C	T			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr3:108278852C>T	ENST00000295746.8	-	15	1927	c.1851G>A	c.(1849-1851)gtG>gtA	p.V617V	KIAA1524_ENST00000491772.1_Silent_p.V458V	NM_020890.2	NP_065941.2	Q8TCG1	CIP2A_HUMAN	KIAA1524	617						cytoplasm|integral to membrane	protein binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(21)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						CAGATATTCTCACATCACAAA	0.254000													5	35					0	0	1	0	0
TSC22D1	8848	broad.mit.edu	37	13	45148706	45148708	+	In_Frame_Del	DEL	TGC	TGC	-	rs112613609		TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr13:45148706_45148708delTGC	ENST00000458659.2	-	1	1993_1995	c.1503_1505delGCA	c.(1501-1506)caa>ca	p.QQ507del	TSC22D1_ENST00000501704.2_In_Frame_Del_p.QQ507del	NM_183422.3	NP_904358.2	Q15714	T22D1_HUMAN	TSC22 domain family, member 1	507	Gln-rich.				transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding transcription factor activity			breast(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_hematologic(4;8.74e-08)|Acute lymphoblastic leukemia(4;1.78e-07)|Lung NSC(96;2.21e-05)|Breast(139;0.000625)|Prostate(109;0.000947)|Hepatocellular(98;0.0202)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;0.000522)|BRCA - Breast invasive adenocarcinoma(63;0.118)		ttgttgttgttgctgctgctgct	0.507													8	98	---	---	---	---					
RP11-597A11.1	0	broad.mit.edu	37	14	20138376	20138376	+	RNA	DEL	G	G	-	rs57620493		TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr14:20138376delG	ENST00000548261.1	+	0	391																											ACAaaagaaagaaagaaagaa	0.388													3	4	---	---	---	---					
SYNE3	161176	broad.mit.edu	37	14	95921888	95921890	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr14:95921888_95921890delCTC	ENST00000334258.5	-	5	975_977	c.961_963delGAG	c.(961-963)del	p.E321del	SYNE3_ENST00000553340.1_In_Frame_Del_p.E321del|SYNE3_ENST00000554873.1_In_Frame_Del_p.E78del|SYNE3_ENST00000557275.1_In_Frame_Del_p.E321del	NM_152592.3	NP_689805.3			spectrin repeat containing, nuclear envelope family member 3											breast(1)|endometrium(2)|lung(25)	28						CCCGCAGCCGCTCCTCCTCCTCC	0.616													7	271	---	---	---	---					
PKD1L2	114780	broad.mit.edu	37	16	81183625	81183626	+	RNA	DEL	TT	TT	-	rs11296516		TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr16:81183625_81183626delTT	ENST00000525539.1	-	0	4553				PKD1L2_ENST00000533478.1_RNA	NM_052892.3	NP_443124.3	Q7Z442	PK1L2_HUMAN	polycystic kidney disease 1-like 2						neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						TTGTTCACACtttttttttttt	0.465													3	3	---	---	---	---					
TBC1D3P2	440452	broad.mit.edu	37	17	60347260	60347260	+	RNA	DEL	T	T	-	rs71816198		TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr17:60347260delT	ENST00000581291.1	-	0	581																				breast(2)|kidney(1)|lung(2)	5						CTCTGAATGATTTTTTTTTTT	0.448													4	5	---	---	---	---					
RP13-329D4.3	0	broad.mit.edu	37	20	26113543	26113543	+	RNA	DEL	A	A	-			TCGA-BB-A5HU-01A-11D-A28R-08	TCGA-BB-A5HU-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7f0cb9f-e525-44b3-a405-8b211dd44b8a	6b63db96-19a4-4904-9cb2-b4f584de603d	g.chr20:26113543delA	ENST00000416563.1	-	0	250																											TCTTTGCCTTAACAACATTAT	0.363													2	4	---	---	---	---