Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
UBR4	23352	broad.mit.edu	37	1	19404540	19404540	+	Missense_Mutation	SNP	T	T	C			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr1:19404540T>C	ENST00000375267.2	-	104	15257	c.15254A>G	c.(15253-15255)aAg>aGg	p.K5085R	UBR4_ENST00000375225.3_Missense_Mutation_p.K160R|UBR4_ENST00000543981.1_Missense_Mutation_p.K749R|UBR4_ENST00000375254.3_Missense_Mutation_p.K5085R|UBR4_ENST00000375224.1_Missense_Mutation_p.K792R|UBR4_ENST00000429347.2_Missense_Mutation_p.K608R|UBR4_ENST00000375226.2_Missense_Mutation_p.K5061R|UBR4_ENST00000375217.2_Missense_Mutation_p.K5078R			Q5T4S7	UBR4_HUMAN	ubiquitin protein ligase E3 component n-recognin 4	5085					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		GGAATAGTCCTTCACTGCCTT	0.493000													13	31					0	0	1	0	0
FPGT-TNNI3K	100526835	broad.mit.edu	37	1	74715151	74715151	+	Missense_Mutation	SNP	A	A	C			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr1:74715151A>C	ENST00000370895.1	+	5	496	c.461A>C	c.(460-462)gAa>gCa	p.E154A	TNNI3K_ENST00000326637.3_Missense_Mutation_p.E53A|FPGT-TNNI3K_ENST00000557284.1_Missense_Mutation_p.E154A|TNNI3K_ENST00000370891.2_Missense_Mutation_p.E154A|FPGT-TNNI3K_ENST00000370899.3_Missense_Mutation_p.E154A			Q59H18	TNI3K_HUMAN		53						cytoplasm|nucleus	ATP binding|metal ion binding|protein C-terminus binding|protein serine/threonine kinase activity|troponin I binding										AGCTCTGATGAAGCCTTCAGT	0.323000													11	32					0	0	1	0	0
KIAA0408	9729	broad.mit.edu	37	6	127767648	127767648	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr6:127767648C>G	ENST00000483725.3	-	5	2152	c.1816G>C	c.(1816-1818)Gaa>Caa	p.E606Q	SOGA3_ENST00000481848.2_3'UTR|SOGA3_ENST00000556132.1_3'UTR	NM_014702.4	NP_055517.3	Q6ZU52	K0408_HUMAN	KIAA0408	606							protein binding			endometrium(3)|large_intestine(7)|lung(15)|ovary(1)|pancreas(1)|skin(1)	28				GBM - Glioblastoma multiforme(226;0.0217)|all cancers(137;0.13)		TGGAGCATTTCTAAATGCTGA	0.428000													31	176					0	0	1	0	0
ANO7	50636	broad.mit.edu	37	2	242163542	242163542	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr2:242163542C>T	ENST00000274979.8	+	25	2879	c.2776C>T	c.(2776-2778)Ccc>Tcc	p.P926S		NM_001001891.3	NP_001001891.2	Q6IWH7	ANO7_HUMAN	anoctamin 7	926						cell junction|chloride channel complex|cytosol	chloride channel activity			NS(1)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(14)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(2)	32						CTTCACGGTTCCCAAGGCCAG	0.647000													11	79					0	0	1	0	0
OR4K5	79317	broad.mit.edu	37	14	20389482	20389482	+	Silent	SNP	G	G	T	rs137857056		TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr14:20389482G>T	ENST00000315915.4	+	1	742	c.717G>T	c.(715-717)acG>acT	p.T239T		NM_001005483.1	NP_001005483.1	Q8NGD3	OR4K5_HUMAN	olfactory receptor, family 4, subfamily K, member 5	239					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|liver(1)|lung(27)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	47	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CATTTTCTACGCTGGCTTCCC	0.413000													25	154					6.32553e-13	6.78097e-13	1	1	0
BRDT	676	broad.mit.edu	37	1	92447253	92447253	+	Nonsense_Mutation	SNP	C	C	G			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr1:92447253C>G	ENST00000370389.2	+	12	2648	c.1724C>G	c.(1723-1725)tCa>tGa	p.S575*	BRDT_ENST00000402388.1_Nonsense_Mutation_p.S648*|BRDT_ENST00000399546.2_Nonsense_Mutation_p.S648*|BRDT_ENST00000362005.3_Nonsense_Mutation_p.S648*|BRDT_ENST00000394530.3_Nonsense_Mutation_p.S602*	NM_001242810.1	NP_001229739.1	Q58F21	BRDT_HUMAN	bromodomain, testis-specific	648					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein serine/threonine kinase activity|transcription coactivator activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(24)|ovary(1)|prostate(4)|skin(2)|stomach(2)|urinary_tract(2)	56		all_lung(203;0.00531)|Lung NSC(277;0.0194)		all cancers(265;0.0228)|Epithelial(280;0.133)		agcagcTCATCAGAGTCTGAA	0.453000													23	46					0	0	1	0	0
USP17L2	377630	broad.mit.edu	37	8	11995295	11995295	+	Silent	SNP	G	G	A			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr8:11995295G>A	ENST00000333796.3	-	1	1291	c.975C>T	c.(973-975)caC>caT	p.H325H	FAM66D_ENST00000434078.2_RNA	NM_001256869.1|NM_001256871.1|NM_001256872.1|NM_001256873.1|NM_001256874.1|NM_201402.2	NP_001243798.1|NP_001243800.1|NP_001243801.1|NP_001243802.1|NP_001243803.1|NP_958804.2	Q6R6M4	U17L2_HUMAN	ubiquitin specific peptidase 17-like family member 2	325					apoptosis|cell cycle|G2/M transition checkpoint|mitotic cell cycle G1/S transition checkpoint|protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			central_nervous_system(1)|kidney(1)|large_intestine(11)|liver(1)|lung(8)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	29						TCCACCCAGCGTGGACCAGCA	0.488000													6	101					0	0	1	0	0
ATP8B4	79895	broad.mit.edu	37	15	50330967	50330967	+	Missense_Mutation	SNP	G	G	T			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr15:50330967G>T	ENST00000284509.6	-	6	501	c.360C>A	c.(358-360)agC>agA	p.S120R	ATP8B4_ENST00000558959.1_5'UTR|ATP8B4_ENST00000559829.1_Missense_Mutation_p.S120R	NM_024837.2	NP_079113.2	Q8TF62	AT8B4_HUMAN	ATPase, class I, type 8B, member 4	120					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|urinary_tract(1)	73		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		TTTCTTACTTGCTGTTGATGA	0.368000													9	49					1.76689e-08	1.87908e-08	1	1	0
CCDC36	339834	broad.mit.edu	37	3	49293706	49293706	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr3:49293706G>A	ENST00000438782.1	+	8	1012	c.776G>A	c.(775-777)aGa>aAa	p.R259K	CCDC36_ENST00000296449.5_Missense_Mutation_p.R259K|CCDC36_ENST00000452691.2_Missense_Mutation_p.R259K			Q8IYA8	CCD36_HUMAN	coiled-coil domain containing 36	259										endometrium(1)|kidney(2)|large_intestine(3)|liver(1)|lung(3)|ovary(1)|urinary_tract(3)	14				BRCA - Breast invasive adenocarcinoma(193;9.11e-05)|Kidney(197;0.00248)|KIRC - Kidney renal clear cell carcinoma(197;0.00262)		GAGCTGAAGAGATTGATCTCA	0.522000													11	79					0	0	1	0	0
P2RY8	286530	broad.mit.edu	37	X	1584402	1584402	+	Silent	SNP	G	G	A			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chrX:1584402G>A	ENST00000381297.4	-	2	1260	c.1050C>T	c.(1048-1050)ccC>ccT	p.P350P		NM_178129.4	NP_835230.1	Q86VZ1	P2RY8_HUMAN	purinergic receptor P2Y, G-protein coupled, 8	350						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(2)|lung(13)|prostate(1)	23		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TCTGGAGGCCGGGCCTGGTGG	0.716000			T	CRLF2	"""B-ALL, Downs associated ALL"""								16	93					0	0	1	0	0
OR5M3	219482	broad.mit.edu	37	11	56237425	56237425	+	Silent	SNP	G	G	A			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr11:56237425G>A	ENST00000312240.2	-	1	589	c.549C>T	c.(547-549)atC>atT	p.I183I		NM_001004742.2	NP_001004742.2	Q8NGP4	OR5M3_HUMAN	olfactory receptor, family 5, subfamily M, member 3	183					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(2)|endometrium(2)|large_intestine(7)|lung(15)|ovary(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	37	Esophageal squamous(21;0.00448)					AGGCCATTTTGATGAGAGGTG	0.403000													10	176					0	0	1	0	0
ATP13A3	79572	broad.mit.edu	37	3	194171001	194171001	+	Silent	SNP	T	T	G			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr3:194171001T>G	ENST00000439040.1	-	11	1634	c.843A>C	c.(841-843)atA>atC	p.I281I	ATP13A3_ENST00000256031.4_Silent_p.I281I			Q9H7F0	AT133_HUMAN	ATPase type 13A3	281					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			NS(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	24	all_cancers(143;6.01e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;3.83e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;5.98e-05)		AGATTTCTTCTATTTCTGAAA	0.338000													5	28					0	0	1	0	0
WDR60	55112	broad.mit.edu	37	7	158695177	158695177	+	Missense_Mutation	SNP	A	A	G			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr7:158695177A>G	ENST00000407559.3	+	10	1406	c.1248A>G	c.(1246-1248)atA>atG	p.I416M		NM_018051.4	NP_060521.4	Q8WVS4	WDR60_HUMAN	WD repeat domain 60	416										NS(3)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(2)|liver(4)|lung(16)|ovary(2)	35	Ovarian(565;0.152)	all_cancers(7;1.25e-09)|all_epithelial(9;0.000894)|all_hematologic(28;0.00603)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)|STAD - Stomach adenocarcinoma(7;0.18)		AAAAGGAAATACAAGAAATTC	0.363000													18	55					0	0	1	0	0
APEH	327	broad.mit.edu	37	3	49716303	49716303	+	Missense_Mutation	SNP	A	A	T			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr3:49716303A>T	ENST00000296456.5	+	12	1479	c.1079A>T	c.(1078-1080)tAc>tTc	p.Y360F	APEH_ENST00000438011.1_Missense_Mutation_p.Y360F	NM_001640.3	NP_001631.3	P13798	ACPH_HUMAN	acylaminoacyl-peptide hydrolase	360					proteolysis	cytoplasm|nuclear membrane	serine-type endopeptidase activity			endometrium(3)|large_intestine(1)|lung(6)|ovary(1)|skin(1)|stomach(2)|urinary_tract(1)	15				BRCA - Breast invasive adenocarcinoma(193;4.53e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		TCTGGGATCTACTGCAGCCTT	0.567000													20	102					0	0	1	0	0
DHX57	90957	broad.mit.edu	37	2	39025462	39025462	+	Silent	SNP	C	C	T			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr2:39025462C>T	ENST00000295373.6	-	24	4266	c.4140G>A	c.(4138-4140)gtG>gtA	p.V1380V		NM_198963.1	NP_945314.1	Q6P158	DHX57_HUMAN	DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57	1380							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(9)|kidney(2)|large_intestine(15)|lung(20)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	62		all_hematologic(82;0.248)				TGACAAGTTTCACAATTGTGC	0.448000													10	111					0	0	1	0	0
NTRK3	4916	broad.mit.edu	37	15	88472443	88472443	+	Silent	SNP	G	G	C			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr15:88472443G>C	ENST00000394480.1	-	17	2433	c.2112C>G	c.(2110-2112)gtC>gtG	p.V704V	NTRK3_ENST00000357724.2_Silent_p.V696V|NTRK3_ENST00000557856.1_Silent_p.V696V|NTRK3_ENST00000355254.2_Silent_p.V704V|NTRK3_ENST00000558676.1_Silent_p.V696V|NTRK3_ENST00000542733.2_Silent_p.V606V|NTRK3_ENST00000360948.2_Silent_p.V704V	NM_001243101.1|NM_002530.3	NP_001230030.1|NP_002521.2	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	704	Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(238)	breast(3)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(22)|lung(63)|ovary(6)|pancreas(3)|prostate(1)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)	119			BRCA - Breast invasive adenocarcinoma(143;0.211)			CCGTGCTGTAGACATCTCTGG	0.517000			T	ETV6	"""congenital fibrosarcoma, Secretory breast """					TSP Lung(13;0.10)			21	101					0	0	1	0	0
NDUFS8	4728	broad.mit.edu	37	11	67800624	67800624	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr11:67800624C>G	ENST00000313468.5	+	5	353	c.246C>G	c.(244-246)atC>atG	p.I82M	NDUFS8_ENST00000528492.1_Intron	NM_002496.3	NP_002487.1	O00217	NDUS8_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)	82					mitochondrial electron transport, NADH to ubiquinone|mitochondrial respiratory chain complex I assembly|response to oxidative stress|transport	mitochondrial respiratory chain complex I	4 iron, 4 sulfur cluster binding|electron carrier activity|metal ion binding|NADH dehydrogenase (ubiquinone) activity			endometrium(1)|kidney(1)|lung(5)|skin(1)	8					NADH(DB00157)	CGGCCACCATCAACTACCCGT	0.682000													4	33					0	0	1	0	0
PHEX	5251	broad.mit.edu	37	X	22117215	22117215	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chrX:22117215G>A	ENST00000379374.4	+	9	1590	c.1025G>A	c.(1024-1026)cGc>cAc	p.R342H	PHEX_ENST00000418858.3_Missense_Mutation_p.R45H|PHEX_ENST00000537599.1_Missense_Mutation_p.R342H|PHEX_ENST00000475778.1_3'UTR|PHEX_ENST00000535894.1_Missense_Mutation_p.R245H	NM_000444.4	NP_000435.3	P78562	PHEX_HUMAN	phosphate regulating endopeptidase homolog, X-linked	342					biomineral tissue development|cell-cell signaling|protein modification process|proteolysis|skeletal system development	integral to plasma membrane	aminopeptidase activity|metalloendopeptidase activity|zinc ion binding	p.R342H(1)		breast(1)|cervix(2)|endometrium(2)|large_intestine(12)|liver(1)|lung(19)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	42						GTGGTGGTCCGCGTCCCGCAG	0.448000													8	125					0	0	1	0	0
ARHGAP4	393	broad.mit.edu	37	X	153178906	153178906	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chrX:153178906C>T	ENST00000370028.3	-	10	1460	c.1403G>A	c.(1402-1404)cGg>cAg	p.R468Q	ARHGAP4_ENST00000537206.1_Missense_Mutation_p.R405Q|ARHGAP4_ENST00000370016.1_Missense_Mutation_p.R407Q|ARHGAP4_ENST00000350060.5_Missense_Mutation_p.R428Q|ARHGAP4_ENST00000393721.1_Missense_Mutation_p.R250Q	NM_001164741.1	NP_001158213.1	P98171	RHG04_HUMAN	Rho GTPase activating protein 4	428					apoptosis|cytoskeleton organization|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|Rho protein signal transduction	cytosol|focal adhesion|nucleus	Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			central_nervous_system(2)|endometrium(2)|large_intestine(1)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	14	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GCCGCGCCTCCGGCCCGCCTG	0.692000													6	99					0	0	1	0	0
BUB1	699	broad.mit.edu	37	2	111419371	111419371	+	Silent	SNP	C	C	G			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr2:111419371C>G	ENST00000535254.1	-	9	1012	c.945G>C	c.(943-945)ctG>ctC	p.L315L	BUB1_ENST00000302759.6_Silent_p.L335L|BUB1_ENST00000409311.1_Silent_p.L335L	NM_001278616.1	NP_001265545.1	O43683	BUB1_HUMAN	BUB1 mitotic checkpoint serine/threonine kinase	335					apoptosis|cell division|chromosome segregation|interspecies interaction between organisms|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|regulation of sister chromatid cohesion	condensed chromosome kinetochore|cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			breast(3)|endometrium(8)|kidney(4)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|stomach(1)	45		Ovarian(717;0.0822)		BRCA - Breast invasive adenocarcinoma(221;0.0556)		ATGGCGCTCTCAGTTCCTGCT	0.453000													14	116					0	0	1	0	0
ARNT	405	broad.mit.edu	37	1	150807017	150807017	+	Missense_Mutation	SNP	A	A	T			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr1:150807017A>T	ENST00000358595.5	-	8	1000	c.800T>A	c.(799-801)aTg>aAg	p.M267K	ARNT_ENST00000515192.1_Missense_Mutation_p.M258K|ARNT_ENST00000505755.1_Missense_Mutation_p.M252K|ARNT_ENST00000468970.1_5'UTR|ARNT_ENST00000354396.2_Missense_Mutation_p.M267K	NM_001197325.1|NM_001668.3|NM_178427.2	NP_001184254.1|NP_001659.1|NP_848514.1	P27540	ARNT_HUMAN	aryl hydrocarbon receptor nuclear translocator	267					positive regulation of hormone biosynthetic process|positive regulation vascular endothelial growth factor production|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|response to hypoxia		aryl hydrocarbon receptor binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(11)|prostate(2)|skin(4)|stomach(1)	34	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.02)|BRCA - Breast invasive adenocarcinoma(12;0.00606)|LUSC - Lung squamous cell carcinoma(543;0.211)			CACTCACCTCATTCGGCAAAT	0.438000			T	ETV6	AML								7	102					0	0	1	0	0
INF2	64423	broad.mit.edu	37	14	105174314	105174314	+	Silent	SNP	G	G	A			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr14:105174314G>A	ENST00000392634.4	+	8	1822	c.1710G>A	c.(1708-1710)caG>caA	p.Q570Q	INF2_ENST00000330634.7_Silent_p.Q570Q	NM_022489.3	NP_071934.3	Q27J81	INF2_HUMAN	inverted formin, FH2 and WH2 domain containing	570	FH2.				actin cytoskeleton organization	endoplasmic reticulum|nucleus|perinuclear region of cytoplasm	actin binding|Rho GTPase binding			large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	8		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00188)|OV - Ovarian serous cystadenocarcinoma(23;0.0191)|Epithelial(46;0.047)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.176)		TGAACTGGCAGAAGCTGCCAT	0.652000													10	55					0	0	1	0	0
MYH14	79784	broad.mit.edu	37	19	50781460	50781460	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr19:50781460G>C	ENST00000440075.2	+	30	3993	c.3946G>C	c.(3946-3948)Gag>Cag	p.E1316Q	MYH14_ENST00000598205.1_Missense_Mutation_p.E1283Q|MYH14_ENST00000596571.1_Missense_Mutation_p.E1275Q|MYH14_ENST00000425460.1_Missense_Mutation_p.E1283Q|MYH14_ENST00000376970.2_Missense_Mutation_p.E1308Q|MYH14_ENST00000601313.1_Missense_Mutation_p.E1316Q|MYH14_ENST00000262269.8_Missense_Mutation_p.E1316Q			Q7Z406	MYH14_HUMAN	myosin, heavy chain 14, non-muscle	1275					axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	46		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		GCGCCGCCTGGAGTTACAGCT	0.697000													6	17					0	0	1	0	0
LILRB5	10990	broad.mit.edu	37	19	54755938	54755938	+	Silent	SNP	G	G	A			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr19:54755938G>A	ENST00000450632.1	-	12	1658	c.1581C>T	c.(1579-1581)gaC>gaT	p.D527D	LILRB5_ENST00000449561.2_Silent_p.D536D|LILRB5_ENST00000316219.5_Silent_p.D535D|LILRB5_ENST00000345866.6_Silent_p.D436D			O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5	535					cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(5)|large_intestine(12)|lung(25)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TCTCCACCCCGTCCTTGGGCT	0.622000													55	127					0	0	1	0	0
ASXL1	171023	broad.mit.edu	37	20	31022345	31022345	+	Silent	SNP	C	C	T			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr20:31022345C>T	ENST00000375687.4	+	13	2254	c.1830C>T	c.(1828-1830)ggC>ggT	p.G610G	ASXL1_ENST00000306058.5_Silent_p.G605G	NM_015338.5	NP_056153.2	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 (Drosophila)	610					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding	p.Q592fs*5(1)|p.G610G(1)		NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(655)|kidney(5)|large_intestine(18)|liver(1)|lung(27)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	722						GTTGGACTGGCGCCAGGACCC	0.632000			"""F, N, Mis"""		"""MDS, CMML"""								4	48					0	0	1	0	0
CCDC91	55297	broad.mit.edu	37	12	28702043	28702043	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr12:28702043C>G	ENST00000545336.1	+	16	1682	c.1263C>G	c.(1261-1263)ttC>ttG	p.F421L	CCDC91_ENST00000540401.1_3'UTR|CCDC91_ENST00000539107.1_Missense_Mutation_p.F385L|CCDC91_ENST00000306172.5_Missense_Mutation_p.F391L|CCDC91_ENST00000381259.1_Missense_Mutation_p.F421L|CCDC91_ENST00000381256.1_Missense_Mutation_p.F385L			Q7Z6B0	CCD91_HUMAN	coiled-coil domain containing 91	421					protein transport	Golgi apparatus|membrane				NS(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(8)|skin(1)	22	Acute lymphoblastic leukemia(23;0.00718)|all_hematologic(23;0.0113)|Lung SC(9;0.184)					TGGAACTGTTCCTCTCCTGTG	0.378000													18	139					0	0	1	0	0
NDST3	9348	broad.mit.edu	37	4	119161817	119161817	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr4:119161817G>A	ENST00000296499.5	+	11	2660	c.2257G>A	c.(2257-2259)Gag>Aag	p.E753K		NM_004784.2	NP_004775.1	O95803	NDST3_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3	753	Heparan sulfate N-sulfotransferase 3.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			NS(1)|breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(23)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	54						CAGCCACATCGAGAGATGGCT	0.473000													6	51					0	0	1	0	0
AGO4	192670	broad.mit.edu	37	1	36315806	36315806	+	Missense_Mutation	SNP	A	A	G			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr1:36315806A>G	ENST00000373210.3	+	16	2469	c.2224A>G	c.(2224-2226)Atc>Gtc	p.I742V	AGO4_ENST00000488778.1_3'UTR	NM_017629.3	NP_060099.2			argonaute RISC catalytic component 4																		GGATAGTACCATCACACATCC	0.398000													11	106					0	0	1	0	0
ENPP2	5168	broad.mit.edu	37	8	120650707	120650707	+	Missense_Mutation	SNP	G	G	C	rs138726849		TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr8:120650707G>C	ENST00000427067.2	-	2	262	c.82C>G	c.(82-84)Cga>Gga	p.R28G	ENPP2_ENST00000075322.6_Missense_Mutation_p.R32G|ENPP2_ENST00000259486.6_Missense_Mutation_p.R32G|ENPP2_ENST00000522826.1_Missense_Mutation_p.R32G			Q13822	ENPP2_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 2	32					cellular component movement|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|phosphate metabolic process|phosphatidylcholine catabolic process|regulation of cell migration	extracellular space|integral to plasma membrane	alkylglycerophosphoethanolamine phosphodiesterase activity|calcium ion binding|lysophospholipase activity|nucleic acid binding|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity|transcription factor binding|zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(30)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)	69	Lung NSC(37;5.03e-06)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			CTCTTAATTCGATGTGCAGTG	0.373000													22	125					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179546391	179546391	+	Missense_Mutation	SNP	T	T	C			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr2:179546391T>C	ENST00000589042.1	-	136	33393	c.33169A>G	c.(33169-33171)Aaa>Gaa	p.K11057E	TTN_ENST00000359218.5_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.K9813E|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000431752.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.K10740E|TTN-AS1_ENST00000589830.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	10740	Glu-rich.|Pro-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACTCTACCTTTAGCCGGTGGG	0.388000													6	50					0	0	1	0	0
C5orf55	116349	broad.mit.edu	37	5	442703	442703	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr5:442703G>C	ENST00000408966.2	-	1	555	c.235C>G	c.(235-237)Cgt>Ggt	p.R79G		NM_138464.2	NP_612473.1	Q8N2X6	CE055_HUMAN	chromosome 5 open reading frame 55	79						extracellular region				large_intestine(1)|lung(2)	3						TTGTTCCCACGAGGGTGCCAA	0.612000													56	176					0	0	1	0	0
LAMA2	3908	broad.mit.edu	37	6	129691085	129691085	+	Missense_Mutation	SNP	G	G	C	rs138303386	byFrequency	TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr6:129691085G>C	ENST00000421865.2	+	34	4958	c.4909G>C	c.(4909-4911)Gag>Cag	p.E1637Q		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	1637	Domain II and I.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity	p.E1637K(1)		NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		TCAGCTGGCAGAGGGCAATCT	0.448000													11	73					0	0	1	0	0
SERPINB1	1992	broad.mit.edu	37	6	2833940	2833940	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr6:2833940G>A	ENST00000380739.5	-	7	1244	c.1042C>T	c.(1042-1044)Ccc>Tcc	p.P348S	SERPINB1_ENST00000537185.1_Missense_Mutation_p.P197S			P30740	ILEU_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 1	348					regulation of proteolysis	cytoplasm|extracellular space	serine-type endopeptidase inhibitor activity			breast(4)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|liver(1)|lung(2)|ovary(2)	13	Ovarian(93;0.0412)			OV - Ovarian serous cystadenocarcinoma(45;0.0717)		TTTTCTTCGGGCATCAACATG	0.443000													8	46					0	0	1	0	0
EGFR	1956	broad.mit.edu	37	7	55229200	55229200	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr7:55229200G>A	ENST00000275493.2	+	13	1684	c.1507G>A	c.(1507-1509)Ggc>Agc	p.G503S	EGFR_ENST00000342916.3_Missense_Mutation_p.G503S|EGFR_ENST00000455089.1_Missense_Mutation_p.G458S|EGFR_ENST00000442591.1_Missense_Mutation_p.G503S|EGFR_ENST00000344576.2_Missense_Mutation_p.G503S|EGFR_ENST00000454757.2_Missense_Mutation_p.G450S	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	503					activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	AGAGGCCACAGGCCAGGTCTG	0.692000		8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			17	90					0	0	1	0	0
AOX1	316	broad.mit.edu	37	2	201507423	201507423	+	Missense_Mutation	SNP	T	T	C			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr2:201507423T>C	ENST00000374700.2	+	25	2987	c.2746T>C	c.(2746-2748)Tcc>Ccc	p.S916P	AOX1_ENST00000485106.1_3'UTR	NM_001159.3	NP_001150.3	Q06278	ADO_HUMAN	aldehyde oxidase 1	916					inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			breast(5)|endometrium(3)|kidney(4)|large_intestine(13)|lung(38)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	81					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	CAACCTTCCATCCAACACAGC	0.493000													11	73					0	0	1	0	0
ZMYM4	9202	broad.mit.edu	37	1	35836031	35836031	+	Missense_Mutation	SNP	G	G	T			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr1:35836031G>T	ENST00000314607.6	+	7	1064	c.984G>T	c.(982-984)atG>atT	p.M328I	ZMYM4_ENST00000482131.1_3'UTR|ZMYM4_ENST00000373297.2_Missense_Mutation_p.M328I	NM_005095.2	NP_005086.2	Q5VZL5	ZMYM4_HUMAN	zinc finger, MYM-type 4	328					multicellular organismal development		DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(16)|ovary(2)|prostate(3)|skin(2)	54		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				TGAATAAAATGCTTCCTTCAG	0.393000													7	74					8.12818e-05	8.31433e-05	1	1	0
KRT85	3891	broad.mit.edu	37	12	52760958	52760958	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr12:52760958G>A	ENST00000257901.3	-	1	307	c.232C>T	c.(232-234)Cgc>Tgc	p.R78C		NM_002283.3	NP_002274.1	P78386	KRT85_HUMAN	keratin 85	78	Head.		R -> H (in EDPHN; dbSNP:rs61630004).		epidermis development	keratin filament	protein binding|structural molecule activity			NS(1)|breast(1)|endometrium(6)|kidney(1)|large_intestine(7)|liver(1)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	36	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)		CCGAAGCTGCGTCCGCAGGAG	0.697000													8	89					0	0	1	0	0
LOC645752	645752	broad.mit.edu	37	15	78212571	78212571	+	RNA	SNP	G	G	A			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr15:78212571G>A	ENST00000565869.1	+	0	111				RP11-114H24.2_ENST00000567226.1_RNA																							CCTGTGTCACGTGTGCGTTCA	0.572000													6	44					0	0	1	0	0
TNR	7143	broad.mit.edu	37	1	175355319	175355319	+	Silent	SNP	G	G	A			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr1:175355319G>A	ENST00000367674.1	-	8	2334	c.1626C>T	c.(1624-1626)ggC>ggT	p.G542G	TNR_ENST00000263525.2_Silent_p.G542G	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	542	Fibronectin type-III 3.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					CACCTTCCCCGCCCACCAGGC	0.587000													28	45					0	0	1	0	0
GABRR1	2569	broad.mit.edu	37	6	89888658	89888658	+	Missense_Mutation	SNP	A	A	G			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr6:89888658A>G	ENST00000435811.1	-	9	1674	c.1220T>C	c.(1219-1221)aTg>aCg	p.M407T	GABRR1_ENST00000454853.2_Missense_Mutation_p.M424T|GABRR1_ENST00000369451.3_Missense_Mutation_p.M337T	NM_001256703.1	NP_001243632.1	P24046	GBRR1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, rho 1	424					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(7)|lung(16)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	35		all_cancers(76;9.49e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.46e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;0.000114)		BRCA - Breast invasive adenocarcinoma(108;0.00917)	Picrotoxin(DB00466)	CAGCTGCACCATCATCCTGTC	0.557000													18	113					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179455600	179455600	+	Silent	SNP	A	A	G			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr2:179455600A>G	ENST00000589042.1	-	304	61076	c.60852T>C	c.(60850-60852)acT>acC	p.T20284T	TTN_ENST00000359218.5_Silent_p.T11344T|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000342175.6_Silent_p.T11411T|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000590743.1_RNA|TTN_ENST00000342992.6_Silent_p.T17716T|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Silent_p.T11219T|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Silent_p.T18643T|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	18643	Ig-like 111.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGCATTTTCAGTAATGTCAG	0.468000													18	95					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179483378	179483378	+	Silent	SNP	C	C	G			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr2:179483378C>G	ENST00000589042.1	-	251	47123	c.46899G>C	c.(46897-46899)ggG>ggC	p.G15633G	TTN_ENST00000359218.5_Silent_p.G6693G|TTN_ENST00000342175.6_Silent_p.G6760G|TTN-AS1_ENST00000589907.1_RNA|TTN_ENST00000342992.6_Silent_p.G13065G|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Silent_p.G6568G|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000591111.1_Silent_p.G13992G|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589830.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	13992	Ig-like 98.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTTATACCTCCCTTTGTCTC	0.348000													6	59					0	0	1	0	0
XPNPEP3	63929	broad.mit.edu	37	22	41318410	41318410	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr22:41318410C>T	ENST00000357137.4	+	8	1213	c.1129C>T	c.(1129-1131)Cct>Tct	p.P377S	XPNPEP3_ENST00000544094.1_Missense_Mutation_p.P354S	NM_022098.3	NP_071381.1	Q9NQH7	XPP3_HUMAN	X-prolyl aminopeptidase (aminopeptidase P) 3, putative	377					cellular process	mitochondrion	aminopeptidase activity|manganese ion binding|metallopeptidase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|skin(1)|urinary_tract(1)	17						CCTCTGCTTCCCTGGGACAAG	0.478000													30	260					0	0	1	0	0
GTF2E2	2961	broad.mit.edu	37	8	30472202	30472202	+	Silent	SNP	G	G	A			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr8:30472202G>A	ENST00000355904.4	-	4	571	c.289C>T	c.(289-291)Cta>Tta	p.L97L		NM_002095.4	NP_002086.1	P29084	T2EB_HUMAN	general transcription factor IIE, polypeptide 2, beta 34kDa	97					regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	transcription factor TFIIE complex	DNA binding|protein binding			endometrium(2)|kidney(2)|large_intestine(1)|lung(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	12				KIRC - Kidney renal clear cell carcinoma(542;0.113)|Kidney(114;0.135)		TCTAAGGTTAGAGGATGCGTA	0.343000													8	41					0	0	1	0	0
MGA	23269	broad.mit.edu	37	15	42041778	42041778	+	Silent	SNP	G	G	A			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr15:42041778G>A	ENST00000219905.7	+	17	6154	c.5973G>A	c.(5971-5973)aaG>aaA	p.K1991K	MGA_ENST00000570161.1_Silent_p.K1991K|MGA_ENST00000389936.4_Silent_p.K1952K|MGA_ENST00000566586.1_Silent_p.K1782K|MGA_ENST00000545763.1_Silent_p.K1782K	NM_001164273.1	NP_001157745.1	Q8IWI9	MGAP_HUMAN	MGA, MAX dimerization protein	1952						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(33)|ovary(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		AAGAAACGAAGAAGGTTCTAC	0.413000													10	79					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100676068	100676068	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr7:100676068G>C	ENST00000306151.4	+	3	1435	c.1371G>C	c.(1369-1371)atG>atC	p.M457I		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	457	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					TAACAAGTATGCCTGTCAGCA	0.493000													115	518					0	0	1	0	0
TYSND1	219743	broad.mit.edu	37	10	71903626	71903626	+	Silent	SNP	G	G	T			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr10:71903626G>T	ENST00000287078.6	-	2	1268	c.1269C>A	c.(1267-1269)atC>atA	p.I423I	TYSND1_ENST00000494143.1_5'UTR|TYSND1_ENST00000335494.5_Intron	NM_173555.2	NP_775826.2	Q2T9J0	TYSD1_HUMAN	trypsin domain containing 1	423	Serine protease.				proteolysis	peroxisome	serine-type endopeptidase activity			endometrium(2)|large_intestine(2)|liver(1)|lung(3)|prostate(1)	9						CGGGCACAGGGATGGGGACAT	0.592000													7	36					2.7689e-08	2.92151e-08	1	1	0
CCDC146	57639	broad.mit.edu	37	7	76871152	76871152	+	Silent	SNP	C	C	G			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr7:76871152C>G	ENST00000285871.4	+	4	511	c.384C>G	c.(382-384)ctC>ctG	p.L128L	CCDC146_ENST00000431197.1_5'UTR	NM_020879.2	NP_065930.2	Q8IYE0	CC146_HUMAN	coiled-coil domain containing 146	128										breast(3)|central_nervous_system(3)|endometrium(1)|kidney(4)|large_intestine(7)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(2)	34		all_cancers(73;0.128)|all_lung(88;0.0986)|all_epithelial(88;0.163)|Myeloproliferative disorder(862;0.205)				AACAACTTCTCAAGTATCAAA	0.403000													22	63					0	0	1	0	0
CCDC36	339834	broad.mit.edu	37	3	49292911	49292911	+	Silent	SNP	G	G	A			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr3:49292911G>A	ENST00000438782.1	+	7	857	c.621G>A	c.(619-621)aaG>aaA	p.K207K	CCDC36_ENST00000296449.5_Silent_p.K207K|CCDC36_ENST00000452691.2_Silent_p.K207K			Q8IYA8	CCD36_HUMAN	coiled-coil domain containing 36	207										endometrium(1)|kidney(2)|large_intestine(3)|liver(1)|lung(3)|ovary(1)|urinary_tract(3)	14				BRCA - Breast invasive adenocarcinoma(193;9.11e-05)|Kidney(197;0.00248)|KIRC - Kidney renal clear cell carcinoma(197;0.00262)		TTGAGATGAAGAAAAGATTTG	0.393000													15	61					0	0	1	0	0
RTEL1	51750	broad.mit.edu	37	20	62321751	62321751	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr20:62321751G>C	ENST00000318100.4	+	26	3197	c.2370G>C	c.(2368-2370)aaG>aaC	p.K790N	RTEL1_ENST00000370003.1_Missense_Mutation_p.K35N|RTEL1_ENST00000508582.2_Missense_Mutation_p.K814N|RTEL1_ENST00000370018.3_Missense_Mutation_p.K790N|RTEL1-TNFRSF6B_ENST00000482936.1_Missense_Mutation_p.K790N|RTEL1_ENST00000360203.5_Missense_Mutation_p.K790N			Q9NZ71	RTEL1_HUMAN	regulator of telomere elongation helicase 1	790					DNA repair|regulation of double-strand break repair via homologous recombination|telomere maintenance	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_cancers(38;6.47e-12)|all_epithelial(29;3.75e-13)		Epithelial(9;1.25e-09)|all cancers(9;5.13e-09)|BRCA - Breast invasive adenocarcinoma(10;7.26e-05)|OV - Ovarian serous cystadenocarcinoma(5;0.00223)|Colorectal(105;0.107)			GGAAAGCTAAGAGTCTGGACC	0.692000													5	38					0	0	1	0	0
MAGEE2	139599	broad.mit.edu	37	X	75003750	75003750	+	Silent	SNP	G	G	T			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chrX:75003750G>T	ENST00000373359.2	-	1	1329	c.1137C>A	c.(1135-1137)ctC>ctA	p.L379L		NM_138703.4	NP_619648.1	Q8TD90	MAGE2_HUMAN	melanoma antigen family E, 2	379	MAGE 2.									autonomic_ganglia(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						GCTGGACAAGGAGGTAGATGT	0.443000													29	116					5.60225e-13	6.05404e-13	1	1	0
LARGE	9215	broad.mit.edu	37	22	33673130	33673130	+	Silent	SNP	C	C	G			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr22:33673130C>G	ENST00000354992.2	-	15	2560	c.1989G>C	c.(1987-1989)gtG>gtC	p.V663V	LARGE_ENST00000402320.1_Silent_p.V611V|LARGE_ENST00000452586.2_Silent_p.V462V|LARGE_ENST00000437602.2_Silent_p.V614V|LARGE_ENST00000337431.2_Silent_p.V611V|LARGE_ENST00000397394.2_Silent_p.V663V	NM_004737.4	NP_004728.1	O95461	LARGE_HUMAN	like-glycosyltransferase	663					glycosphingolipid biosynthetic process|muscle cell homeostasis|N-acetylglucosamine metabolic process|protein glycosylation	integral to Golgi membrane	acetylglucosaminyltransferase activity			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(23)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	51		Lung NSC(1;0.219)				AGTCACGTCTCACAACAACAT	0.577000													23	82					0	0	1	0	0
FAM71B	153745	broad.mit.edu	37	5	156590665	156590665	+	Missense_Mutation	SNP	G	G	T			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr5:156590665G>T	ENST00000302938.4	-	2	706	c.611C>A	c.(610-612)gCa>gAa	p.A204E		NM_130899.2	NP_570969.2	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	204						nucleus				NS(3)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(32)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GTGGAGCTCTGCAGCCTATAC	0.493000													11	72					0.00829132	0.00841694	1	1	0
APOL3	80833	broad.mit.edu	37	22	36556749	36556749	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr22:36556749G>A	ENST00000349314.2	-	1	228	c.191C>T	c.(190-192)tCt>tTt	p.S64F	APOL3_ENST00000397287.2_5'UTR|APOL3_ENST00000424878.2_5'UTR|APOL3_ENST00000361710.2_5'UTR|APOL3_ENST00000397293.2_5'UTR	NM_145640.2	NP_663615.1	O95236	APOL3_HUMAN	apolipoprotein L, 3	64					inflammatory response|lipoprotein metabolic process|positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|extracellular region	lipid binding|lipid transporter activity|signal transducer activity			endometrium(2)|large_intestine(1)|lung(1)|stomach(1)	5						GTGTGAGCAAGATCCAGCTGT	0.512000													8	105					0	0	1	0	0
CLCNKA	1187	broad.mit.edu	37	1	16352699	16352699	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr1:16352699C>G	ENST00000375692.1	+	6	583	c.455C>G	c.(454-456)tCc>tGc	p.S152C	CLCNKA_ENST00000420078.1_Missense_Mutation_p.S152C|CLCNKA_ENST00000464764.1_3'UTR|CLCNKA_ENST00000439316.2_Missense_Mutation_p.S109C|CLCNKA_ENST00000331433.4_Missense_Mutation_p.S152C			P51800	CLCKA_HUMAN	chloride channel, voltage-sensitive Ka	152					excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			breast(1)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|skin(1)	19		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)	Niflumic Acid(DB04552)	GTGGGCCTCTCCTGCACCCTG	0.617000													12	215					0	0	1	0	0
PTPRK	5796	broad.mit.edu	37	6	128563725	128563725	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr6:128563725G>C	ENST00000368227.3	-	4	884	c.518C>G	c.(517-519)tCa>tGa	p.S173*	PTPRK_ENST00000532331.1_Nonsense_Mutation_p.S173*|PTPRK_ENST00000368215.3_Nonsense_Mutation_p.S173*|PTPRK_ENST00000368207.3_Nonsense_Mutation_p.S173*|PTPRK_ENST00000524481.1_5'UTR|PTPRK_ENST00000368210.3_Nonsense_Mutation_p.S173*|PTPRK_ENST00000368213.5_Nonsense_Mutation_p.S173*|PTPRK_ENST00000368226.4_Nonsense_Mutation_p.S173*			Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	173	MAM.				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity		PTPRK/RSPO3(10)	autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(14)|lung(24)|ovary(3)|pancreas(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	72				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		TCTCCCTCCTGAGACTTCAGC	0.343000													7	26					0	0	1	0	0
IKBKE	9641	broad.mit.edu	37	1	206652357	206652357	+	Missense_Mutation	SNP	A	A	G			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr1:206652357A>G	ENST00000367120.3	+	10	1437	c.1064A>G	c.(1063-1065)gAg>gGg	p.E355G	IKBKE_ENST00000537984.1_Missense_Mutation_p.E270G|IKBKE_ENST00000462698.1_3'UTR	NM_001193322.1|NM_014002.3	NP_001180251.1|NP_054721.1	Q14164	IKKE_HUMAN	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	355					DNA damage response, signal transduction resulting in induction of apoptosis|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of type I interferon production|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane|PML body	ATP binding|IkappaB kinase activity|NF-kappaB-inducing kinase activity|protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(13)|ovary(3)|skin(2)	32	Breast(84;0.137)					TACCTCTTTGAGGGTCACCTC	0.622000													63	140					0	0	1	0	0
BRPF3	27154	broad.mit.edu	37	6	36168560	36168560	+	Missense_Mutation	SNP	A	A	G			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr6:36168560A>G	ENST00000357641.6	+	2	714	c.461A>G	c.(460-462)tAt>tGt	p.Y154C	BRPF3_ENST00000534694.1_Missense_Mutation_p.Y154C|BRPF3_ENST00000443324.2_Missense_Mutation_p.Y154C|BRPF3_ENST00000543502.1_Missense_Mutation_p.Y154C|BRPF3_ENST00000534400.1_Missense_Mutation_p.Y154C|BRPF3_ENST00000339717.7_Missense_Mutation_p.Y154C	NM_015695.2	NP_056510.2	Q9ULD4	BRPF3_HUMAN	bromodomain and PHD finger containing, 3	154					histone H3 acetylation|platelet activation|platelet degranulation	cytosol|extracellular region|MOZ/MORF histone acetyltransferase complex	protein binding|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(15)|ovary(1)|prostate(1)|skin(4)|urinary_tract(2)	40						GAGGTAGAGTATGACATGGAT	0.547000													14	58					0	0	1	0	0
SFI1	9814	broad.mit.edu	37	22	32002333	32002333	+	Missense_Mutation	SNP	A	A	G			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr22:32002333A>G	ENST00000432498.1	+	20	2374	c.1981A>G	c.(1981-1983)Aaa>Gaa	p.K661E	SFI1_ENST00000443326.1_Missense_Mutation_p.K610E|SFI1_ENST00000400288.2_Missense_Mutation_p.K692E|SFI1_ENST00000400289.1_Missense_Mutation_p.K610E|SFI1_ENST00000443011.1_Missense_Mutation_p.K539E|SFI1_ENST00000540643.1_Missense_Mutation_p.K637E|SFI1_ENST00000414585.1_Missense_Mutation_p.K539E	NM_014775.3	NP_055590.2	A8K8P3	SFI1_HUMAN	Sfi1 homolog, spindle assembly associated (yeast)	692					G2/M transition of mitotic cell cycle	centriole|cytosol				NS(2)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|large_intestine(7)|liver(1)|lung(11)|ovary(1)|prostate(3)|upper_aerodigestive_tract(3)	38						ACGTCGCTGGAAAGAGAACAC	0.498000													4	66					0	0	1	0	0
CIITA	4261	broad.mit.edu	37	16	11000940	11000940	+	Missense_Mutation	SNP	G	G	A	rs144646271	byFrequency	TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr16:11000940G>A	ENST00000324288.8	+	11	1724	c.1591G>A	c.(1591-1593)Ggc>Agc	p.G531S	CIITA_ENST00000537380.1_Intron|CIITA_ENST00000381835.5_Intron	NM_000246.3	NP_000237.2	P33076	C2TA_HUMAN	class II, major histocompatibility complex, transactivator	531	NACHT.				interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|response to antibiotic|transcription, DNA-dependent	nucleus	activating transcription factor binding|ATP binding|protein C-terminus binding|protein complex binding|transcription coactivator activity|transcription regulatory region DNA binding			central_nervous_system(1)|large_intestine(7)|ovary(1)|skin(1)|stomach(2)	12						GCTGCTGGCCGGCCTTTTCCA	0.692000			T	"""FLJ27352, CD274, CD273, RALGDS, RUNDC2A, C16orf75, BCL6"""	"""PMBL, Hodgkin Lymphona, """								5	59					0	0	1	0	0
RHOA	387	broad.mit.edu	37	3	49405953	49405953	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr3:49405953C>T	ENST00000418115.1	-	3	569	c.185G>A	c.(184-186)gGg>gAg	p.G62E	RHOA_ENST00000454011.2_Intron|RHOA_ENST00000422781.1_Missense_Mutation_p.G62E	NM_001664.2	NP_001655.1	P61586	RHOA_HUMAN	ras homolog family member A	62					axon guidance|interspecies interaction between organisms|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of axonogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of neuron differentiation|positive regulation of NF-kappaB import into nucleus|positive regulation of stress fiber assembly|regulation of cell migration|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|spindle assembly involved in mitosis	cytoskeleton|cytosol|plasma membrane	GTP binding|GTPase activity|myosin binding			cervix(1)|kidney(1)|large_intestine(5)|lung(1)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	12				BRCA - Breast invasive adenocarcinoma(193;8.58e-05)|Kidney(197;0.0023)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)	Atorvastatin(DB01076)|Simvastatin(DB00641)	ATCTTCCTGCCCAGCTGTGTC	0.473000													16	76					0	0	1	0	0
OR13C3	138803	broad.mit.edu	37	9	107298658	107298658	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr9:107298658C>T	ENST00000374781.2	-	1	479	c.437G>A	c.(436-438)gGc>gAc	p.G146D		NM_001001961.1	NP_001001961.1	Q8NGS6	O13C3_HUMAN	olfactory receptor, family 13, subfamily C, member 3	146					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(7)|lung(7)|pancreas(1)|prostate(1)|skin(1)	19						TGCCATCATGCCAAGAAGCAG	0.463000													32	203					0	0	1	0	0
FILIP1	27145	broad.mit.edu	37	6	76022592	76022592	+	Missense_Mutation	SNP	A	A	C			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr6:76022592A>C	ENST00000393004.2	-	5	3177	c.2956T>G	c.(2956-2958)Ttt>Gtt	p.F986V	FILIP1_ENST00000370020.1_Missense_Mutation_p.F887V|FILIP1_ENST00000498523.1_5'UTR|FILIP1_ENST00000237172.7_Missense_Mutation_p.F986V			Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	986										breast(3)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)	80						TCTCTGGAAAATGTAGTAATT	0.463000													22	94					0	0	1	0	0
SRP68	6730	broad.mit.edu	37	17	74063379	74063379	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr17:74063379C>T	ENST00000307877.2	-	3	445	c.284G>A	c.(283-285)cGa>cAa	p.R95Q	SRP68_ENST00000539137.1_Intron|SRP68_ENST00000355113.5_5'UTR	NM_014230.3	NP_055045.2	Q9UHB9	SRP68_HUMAN	signal recognition particle 68kDa	95					response to drug	cytosol|endoplasmic reticulum|nucleolus|ribosome|signal recognition particle, endoplasmic reticulum targeting	RNA binding|signal recognition particle binding			NS(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(5)|lung(4)|ovary(2)|prostate(3)	23						GAGTGTTTTTCGAAGACGTCT	0.408000													11	88					0	0	1	0	0
KANSL1L	151050	broad.mit.edu	37	2	210962878	210962878	+	Silent	SNP	G	G	A			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr2:210962878G>A	ENST00000281772.9	-	5	1745	c.1482C>T	c.(1480-1482)tcC>tcT	p.S494S	KANSL1L_ENST00000457374.1_Silent_p.S494S|KANSL1L_ENST00000452086.1_Silent_p.S494S|KANSL1L_ENST00000418791.1_Silent_p.S494S	NM_152519.2	NP_689732.2	A0AUZ9	CB067_HUMAN	KAT8 regulatory NSL complex subunit 1-like	494																	ATGAAGTTGGGGACAAGTTGA	0.423000													14	59					0	0	1	0	0
MARVELD3	91862	broad.mit.edu	37	16	71674711	71674711	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr16:71674711G>C	ENST00000299952.4	+	3	1057	c.1014G>C	c.(1012-1014)gaG>gaC	p.E338D	MARVELD3_ENST00000565261.1_3'UTR|MARVELD3_ENST00000561682.1_Intron|PHLPP2_ENST00000540628.1_3'UTR	NM_001017967.2	NP_001017967.2	Q96A59	MALD3_HUMAN	MARVEL domain containing 3	341	MARVEL.					integral to membrane				NS(1)|endometrium(3)|large_intestine(5)|lung(6)|skin(2)	17		Ovarian(137;0.125)				AAACAAGAGAGAGGCTCTATG	0.572000													9	80					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414343	20414343	+	Silent	SNP	A	A	G			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr9:20414343A>G	ENST00000380338.4	-	5	787	c.501T>C	c.(499-501)agT>agC	p.S167S	MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S164S|MLLT3_ENST00000475957.1_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	167	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S167S(19)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctactgctgctgc	0.532000			T	MLL	ALL								4	59					0	0	1	0	0
PLEKHM1P	440456	broad.mit.edu	37	17	62796685	62796685	+	RNA	SNP	G	G	A			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr17:62796685G>A	ENST00000582986.1	-	0	1235					NR_024386.1																						GGTTCCTCAGGCTGGTCTGAG	0.682000													19	54					0	0	1	0	0
HNF1B	6928	broad.mit.edu	37	17	36064972	36064972	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr17:36064972G>C	ENST00000225893.4	-	6	1652	c.1291C>G	c.(1291-1293)Caa>Gaa	p.Q431E	HNF1B_ENST00000427275.2_Missense_Mutation_p.Q405E|HNF1B_ENST00000561193.1_Missense_Mutation_p.Q405E|HNF1B_ENST00000560016.1_Missense_Mutation_p.Q431E	NM_000458.2|NM_001165923.1	NP_000449.1|NP_001159395.1	P35680	HNF1B_HUMAN	HNF1 homeobox B	431					endocrine pancreas development|genitalia development|kidney development|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|pronephric nephron tubule development|regulation of pronephros size	nucleus	DNA binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(6)|kidney(3)|large_intestine(2)|liver(1)|lung(3)|ovary(3)|prostate(1)|skin(2)	28		Breast(25;0.00765)|Ovarian(249;0.15)	STAD - Stomach adenocarcinoma(1;0.0142)			ATGAGGTTTTGAGATTGCTGG	0.488000													13	69					0	0	1	0	0
KIAA0196	9897	broad.mit.edu	37	8	126087290	126087290	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr8:126087290C>T	ENST00000318410.7	-	8	1277	c.928G>A	c.(928-930)Gca>Aca	p.A310T	KIAA0196_ENST00000517845.1_Missense_Mutation_p.A162T	NM_014846.3	NP_055661.3	Q12768	STRUM_HUMAN	KIAA0196	310					cell death	WASH complex				NS(1)|breast(3)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	42	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			GCAGTTTTTGCAGCTTTGTAA	0.378000													6	77					0	0	1	0	0
YOD1	55432	broad.mit.edu	37	1	207222776	207222776	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr1:207222776C>T	ENST00000367084.1	-	4	708	c.504G>A	c.(502-504)tgG>tgA	p.W168*	YOD1_ENST00000315927.4_Nonsense_Mutation_p.W212*|YOD1_ENST00000391927.1_Nonsense_Mutation_p.W168*	NM_001276320.1	NP_001263249.1	Q5VVQ6	OTU1_HUMAN	YOD1 deubiquitinase	212	OTU.				cellular amino acid metabolic process|endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|protein K48-linked deubiquitination|protein K63-linked deubiquitination	intracellular	protein binding|ubiquitin-specific protease activity|zinc ion binding			cervix(1)|endometrium(3)|large_intestine(1)|lung(3)|ovary(3)	11	Prostate(682;0.19)					CCCTTTTGATCCAGTCACAGT	0.418000													12	222					0	0	1	0	0
OR2M4	26245	broad.mit.edu	37	1	248402920	248402920	+	Silent	SNP	T	T	C			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr1:248402920T>C	ENST00000306687.1	+	1	690	c.690T>C	c.(688-690)tcT>tcC	p.S230S		NM_017504.1	NP_059974.1	Q96R27	OR2M4_HUMAN	olfactory receptor, family 2, subfamily M, member 4	230					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(27)|skin(3)|upper_aerodigestive_tract(2)	50	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			ACATGGGCTCTGGGGAAAGTC	0.488000													21	89					0	0	1	0	0
NOTCH1	4851	broad.mit.edu	37	9	139404312	139404312	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr9:139404312C>A	ENST00000277541.6	-	18	2917	c.2842G>T	c.(2842-2844)Gag>Tag	p.E948*		NM_017617.3	NP_060087.3	P46531	NOTC1_HUMAN	notch 1	948	EGF-like 25; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity	p.E948*(1)|p.E949*(1)		breast(16)|central_nervous_system(17)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1183)|kidney(4)|large_intestine(1)|lung(57)|oesophagus(2)|ovary(3)|pancreas(1)|prostate(3)|skin(21)|upper_aerodigestive_tract(39)|urinary_tract(3)	1359	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		CTGGCACACTCGTTGATGTCC	0.652000			"""T, Mis, O"""	TRB@	T-ALL					HNSCC(8;0.001)			51	115					1.86277e-20	2.04599e-20	1	1	0
DHRS7C	201140	broad.mit.edu	37	17	9680514	9680514	+	Silent	SNP	C	C	T			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr17:9680514C>T	ENST00000330255.4	-	4	582	c.570G>A	c.(568-570)acG>acA	p.T190T	DHRS7C_ENST00000571134.1_Silent_p.T189T	NM_001220493.1	NP_001207422.1	A6NNS2	DRS7C_HUMAN	dehydrogenase/reductase (SDR family) member 7C	190						extracellular region	binding|oxidoreductase activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)	15						ACTTACAAGTCGTACGGAACG	0.423000													4	28					0	0	1	0	0
RTCA	8634	broad.mit.edu	37	1	100741195	100741195	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr1:100741195G>A	ENST00000370128.4	+	7	825	c.656G>A	c.(655-657)aGa>aAa	p.R219K	RTCA_ENST00000260563.4_Missense_Mutation_p.R232K	NM_003729.3	NP_003720.1	O00442	RTC1_HUMAN	RNA 3'-terminal phosphate cyclase	219					RNA processing	mitochondrion|nucleoplasm	ATP binding|protein binding|RNA binding|RNA-3'-phosphate cyclase activity										AGATGCATCAGAAAGGAGATC	0.353000													24	39					0	0	1	0	0
CNGB1	1258	broad.mit.edu	37	16	57992361	57992361	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr16:57992361C>G	ENST00000564448.1	-	11	832	c.772G>C	c.(772-774)Gag>Cag	p.E258Q	CNGB1_ENST00000251102.8_Missense_Mutation_p.E264Q|CNGB1_ENST00000311183.4_Missense_Mutation_p.E264Q			Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1	264					sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(7)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(11)|liver(1)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	54						AAGGCCATCTCCAGCCTGTGC	0.622000													11	60					0	0	1	0	0
SCNN1G	6340	broad.mit.edu	37	16	23200873	23200873	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr16:23200873G>C	ENST00000300061.2	+	3	642	c.499G>C	c.(499-501)Gag>Cag	p.E167Q		NM_001039.3	NP_001030.2	P51170	SCNNG_HUMAN	sodium channel, non-voltage-gated 1, gamma subunit	167					excretion|sensory perception of taste	apical plasma membrane|integral to plasma membrane	ligand-gated sodium channel activity|WW domain binding			NS(2)|autonomic_ganglia(1)|breast(1)|cervix(2)|kidney(1)|large_intestine(9)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	34				GBM - Glioblastoma multiforme(48;0.0366)	Amiloride(DB00594)|Triamterene(DB00384)	TGATCAGGATGAGAAGGGCAA	0.562000													25	254					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179482515	179482515	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr2:179482515C>T	ENST00000589042.1	-	253	47787	c.47563G>A	c.(47563-47565)Gat>Aat	p.D15855N	TTN_ENST00000359218.5_Missense_Mutation_p.D6915N|TTN_ENST00000342175.6_Missense_Mutation_p.D6982N|TTN-AS1_ENST00000589907.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.D13287N|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.D6790N|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.D14214N|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589830.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	14214	Fibronectin type-III 15.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCAATTGGATCAGCAACTTTG	0.383000													19	75					0	0	1	0	0
PTK2	5747	broad.mit.edu	37	8	141685543	141685543	+	Missense_Mutation	SNP	T	T	A			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr8:141685543T>A	ENST00000395218.2	-	28	2847	c.2618A>T	c.(2617-2619)aAt>aTt	p.N873I	PTK2_ENST00000430260.2_Intron|PTK2_ENST00000522684.1_Intron|PTK2_ENST00000538769.1_Intron|PTK2_ENST00000521059.1_Intron|PTK2_ENST00000535192.1_Intron|PTK2_ENST00000517887.1_Intron|PTK2_ENST00000340930.3_Missense_Mutation_p.N873I|PTK2_ENST00000519465.1_Intron|PTK2_ENST00000519419.1_Intron			Q05397	FAK1_HUMAN	protein tyrosine kinase 2	867	Interaction with TGFB1I1.|Pro-rich.				axon guidance|blood coagulation|cellular component disassembly involved in apoptosis|ephrin receptor signaling pathway|growth hormone receptor signaling pathway|integrin-mediated signaling pathway|peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of cell adhesion mediated by integrin|signal complex assembly	cytoskeleton|cytosol|focal adhesion	ATP binding|JUN kinase binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(6)|lung(23)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	48	all_cancers(97;1.05e-15)|all_epithelial(106;2.09e-14)|Lung NSC(106;1.61e-06)|all_lung(105;2.5e-06)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;2.72e-05)|Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.137)			TTCCGCCCAATTCTTTTCTTC	0.363000													4	23					0	0	1	0	0
C6	729	broad.mit.edu	37	5	41159288	41159288	+	Silent	SNP	C	C	A			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr5:41159288C>A	ENST00000263413.3	-	12	2016	c.1752G>T	c.(1750-1752)tcG>tcT	p.S584S	C6_ENST00000337836.5_Silent_p.S584S	NM_001115131.1	NP_001108603.2	P13671	CO6_HUMAN	complement component 6	584	TSP type-1 3.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				CTCGGGTTCTCGATCTCTTAT	0.498000													37	69					1.90571e-15	2.07614e-15	1	1	0
DNAH8	1769	broad.mit.edu	37	6	38905899	38905899	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr6:38905899G>A	ENST00000359357.3	+	76	11316	c.11062G>A	c.(11062-11064)Gga>Aga	p.G3688R	DNAH8_ENST00000441566.1_Missense_Mutation_p.G3652R|RP1-207H1.3_ENST00000416948.1_RNA|DNAH8_ENST00000449981.2_Missense_Mutation_p.G3905R					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						AGCCACCCGCGGAAGCATCCT	0.522000													12	64					0	0	1	0	0
HOXC8	3224	broad.mit.edu	37	12	54403466	54403466	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr12:54403466C>T	ENST00000040584.4	+	1	635	c.398C>T	c.(397-399)tCg>tTg	p.S133L		NM_022658.3	NP_073149.1	P31273	HXC8_HUMAN	homeobox C8	133						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)|skin(3)	8						AATCAAAACTCGTCTCCCAGC	0.557000													13	208					0	0	1	0	0
AMOTL1	154810	broad.mit.edu	37	11	94554915	94554915	+	Missense_Mutation	SNP	A	A	G			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr11:94554915A>G	ENST00000433060.2	+	4	1482	c.1341A>G	c.(1339-1341)atA>atG	p.I447M	AMOTL1_ENST00000317837.9_Intron|AMOTL1_ENST00000317829.8_Missense_Mutation_p.I397M|AMOTL1_ENST00000539727.1_3'UTR	NM_130847.2	NP_570899.1	Q8IY63	AMOL1_HUMAN	angiomotin like 1	447						cytoplasm|tight junction	identical protein binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(14)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(2)	36		Acute lymphoblastic leukemia(157;2.38e-05)|all_hematologic(158;0.00824)				TGGTGGAGATATTAACAGAGG	0.602000													9	87					0	0	1	0	0
OR2B3	442184	broad.mit.edu	37	6	29054606	29054606	+	Silent	SNP	G	G	A			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr6:29054606G>A	ENST00000377173.2	-	1	484	c.420C>T	c.(418-420)ttC>ttT	p.F140F		NM_001005226.2	NP_001005226.1			olfactory receptor, family 2, subfamily B, member 3											breast(1)|endometrium(1)|kidney(2)|lung(17)|prostate(1)|skin(2)	24						TCCTTAGGCAGAACCAATAAT	0.488000													17	59					0	0	1	0	0
IL1RAP	3556	broad.mit.edu	37	3	190362143	190362143	+	Silent	SNP	C	C	G			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr3:190362143C>G	ENST00000412504.2	+	9	1410	c.1158C>G	c.(1156-1158)gtC>gtG	p.V386V	IL1RAP_ENST00000072516.3_Silent_p.V386V|IL1RAP_ENST00000447382.1_Silent_p.V386V|IL1RAP_ENST00000317757.3_Silent_p.V386V|IL1RAP_ENST00000443369.2_Silent_p.V386V|IL1RAP_ENST00000439062.1_Silent_p.V386V			Q9NPH3	IL1AP_HUMAN	interleukin 1 receptor accessory protein	386					inflammatory response|innate immune response|protein complex assembly	extracellular region|integral to plasma membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	20	all_cancers(143;3.61e-10)|Ovarian(172;0.0733)|Breast(254;0.21)		Lung(62;1.95e-06)|LUSC - Lung squamous cell carcinoma(58;2.05e-06)	GBM - Glioblastoma multiforme(93;0.00851)		TAGAGATGGTCCTATTTTACC	0.398000													4	45					0	0	1	0	0
PIWIL2	55124	broad.mit.edu	37	8	22213004	22213004	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr8:22213004C>G	ENST00000356766.6	+	23	3056	c.2908C>G	c.(2908-2910)Ctg>Gtg	p.L970V	PIWIL2_ENST00000521356.1_Missense_Mutation_p.L934V|PIWIL2_ENST00000454009.2_Missense_Mutation_p.L970V	NM_018068.3	NP_060538.2	Q8TC59	PIWL2_HUMAN	piwi-like RNA-mediated gene silencing 2	970					DNA methylation involved in gamete generation|gene silencing by RNA|germ-line stem cell maintenance|multicellular organismal development|oogenesis|piRNA metabolic process|positive regulation of translation|RNA 5'-end processing|spermatogenesis	chromatoid body|pi-body	piRNA binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(14)|lung(14)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	46				Colorectal(74;0.018)|COAD - Colon adenocarcinoma(73;0.0707)		GTGCGAGAACCTGTTCTTCCT	0.517000													10	40					0	0	1	0	0
LRRC23	10233	broad.mit.edu	37	12	7014828	7014828	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr12:7014828G>C	ENST00000007969.8	+	2	251	c.31G>C	c.(31-33)Gag>Cag	p.E11Q	LRRC23_ENST00000443597.2_Missense_Mutation_p.E11Q|LRRC23_ENST00000449039.1_3'UTR|LRRC23_ENST00000436789.1_Missense_Mutation_p.E11Q|LRRC23_ENST00000429740.1_Missense_Mutation_p.E11Q|LRRC23_ENST00000433346.1_Missense_Mutation_p.E11Q|LRRC23_ENST00000323702.5_Missense_Mutation_p.E11Q	NM_001135217.1|NM_201650.2	NP_001128689.1|NP_964013.1	Q53EV4	LRC23_HUMAN	leucine rich repeat containing 23	11										NS(1)|breast(1)|endometrium(2)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)|stomach(1)	13						AGAAGACTCTGAGCCAGACCA	0.488000													14	73					0	0	1	0	0
KRT32	3882	broad.mit.edu	37	17	39616419	39616419	+	Silent	SNP	G	G	C			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr17:39616419G>C	ENST00000225899.3	-	7	1393	c.1290C>G	c.(1288-1290)gtC>gtG	p.V430V		NM_002278.3	NP_002269.3	Q14532	K1H2_HUMAN	keratin 32	430	Tail.				epidermis development	intermediate filament	protein binding|structural molecule activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Breast(137;0.000812)				GTGGCACACAGACGGTGCGGG	0.637000													8	30					0	0	1	0	0
RUNX2	860	broad.mit.edu	37	6	45480097	45480097	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr6:45480097G>A	ENST00000371438.1	+	6	1332	c.974G>A	c.(973-975)cGg>cAg	p.R325Q	RUNX2_ENST00000541979.1_Missense_Mutation_p.R393Q|RUNX2_ENST00000359524.5_Missense_Mutation_p.R311Q|RUNX2_ENST00000371432.3_Missense_Mutation_p.R311Q|RUNX2_ENST00000465038.2_Missense_Mutation_p.R325Q|RUNX2_ENST00000371436.6_Missense_Mutation_p.R325Q|RUNX2_ENST00000576263.1_Missense_Mutation_p.R325Q|RUNX2_ENST00000352853.5_Missense_Mutation_p.R393Q	NM_001024630.3	NP_001019801.3	Q13950	RUNX2_HUMAN	runt-related transcription factor 2	325	Pro/Ser/Thr-rich.				negative regulation of transcription, DNA-dependent|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(18)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34						TCTTCCACACGGGGCACTGGG	0.592000													20	100					0	0	1	0	0
DZIP3	9666	broad.mit.edu	37	3	108355486	108355486	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr3:108355486G>C	ENST00000361582.3	+	11	1172	c.942G>C	c.(940-942)ttG>ttC	p.L314F	DZIP3_ENST00000463306.1_Missense_Mutation_p.L314F	NM_014648.3	NP_055463.1	Q86Y13	DZIP3_HUMAN	DAZ interacting zinc finger protein 3	314					protein polyubiquitination	cytoplasm	polyubiquitin binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(9)|lung(21)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	45						AAAAATGTTTGAAGGAAGGAT	0.269000													12	72					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195505836	195505836	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr3:195505836G>C	ENST00000463781.3	-	2	13074	c.12615C>G	c.(12613-12615)caC>caG	p.H4205Q	MUC4_ENST00000349607.4_Intron|MUC4_ENST00000475231.1_Missense_Mutation_p.H4205Q|MUC4_ENST00000346145.4_Intron	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	968					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity	p.H4205Q(10)		NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GAGGGGTGGCGTGACCTGTGG	0.597000													2	1					0	0	1	0	0
DHX40	79665	broad.mit.edu	37	17	57643053	57643053	+	Silent	SNP	C	C	G			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr17:57643053C>G	ENST00000251241.4	+	1	168	c.21C>G	c.(19-21)gtC>gtG	p.V7V	DHX40_ENST00000425628.3_Silent_p.V7V|DHX40_ENST00000451169.2_5'UTR	NM_024612.4	NP_078888.4	Q8IX18	DHX40_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 40	7							ATP binding|ATP-dependent helicase activity|nucleic acid binding			endometrium(7)|large_intestine(6)|lung(6)|prostate(1)	20	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					TTCCCGCAGTCGCGGGCAGGG	0.662000													4	31					0	0	1	0	0
USE1	55850	broad.mit.edu	37	19	17327091	17327091	+	Silent	SNP	G	G	A			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr19:17327091G>A	ENST00000595101.1	+	4	363	c.345G>A	c.(343-345)gcG>gcA	p.A115A	USE1_ENST00000445667.2_Silent_p.A115A|USE1_ENST00000263897.5_Silent_p.A115A|USE1_ENST00000379776.4_Silent_p.A115A|USE1_ENST00000596136.1_Silent_p.A115A			Q9NZ43	USE1_HUMAN	unconventional SNARE in the ER 1 homolog (S. cerevisiae)	115					lysosomal transport|protein catabolic process|protein transport|secretion by cell|vesicle-mediated transport	endoplasmic reticulum membrane|integral to membrane	protein binding			breast(2)|endometrium(1)|lung(3)	6						AGTCACGGGCGCGGTACACCA	0.612000													24	56					0	0	1	0	0
MGA	23269	broad.mit.edu	37	15	42041118	42041118	+	Silent	SNP	G	G	A			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr15:42041118G>A	ENST00000219905.7	+	16	5677	c.5496G>A	c.(5494-5496)cgG>cgA	p.R1832R	MGA_ENST00000570161.1_Silent_p.R1832R|MGA_ENST00000389936.4_Silent_p.R1793R|MGA_ENST00000566586.1_Silent_p.R1623R|MGA_ENST00000545763.1_Silent_p.R1623R	NM_001164273.1	NP_001157745.1	Q8IWI9	MGAP_HUMAN	MGA, MAX dimerization protein	1793						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(33)|ovary(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		TCATGTTTCGGAACCCAGGTA	0.398000													11	67					0	0	1	0	0
BCORL1	63035	broad.mit.edu	37	X	129147516	129147516	+	Silent	SNP	G	G	A			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chrX:129147516G>A	ENST00000540052.1	+	3	812	c.768G>A	c.(766-768)ccG>ccA	p.P256P	BCORL1_ENST00000303743.5_Silent_p.P256P|BCORL1_ENST00000359304.2_Silent_p.P256P|BCORL1_ENST00000218147.7_Silent_p.P256P	NM_021946.4	NP_068765.3	Q5H9F3	BCORL_HUMAN	BCL6 corepressor-like 1	256	Pro-rich.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				breast(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|liver(3)|lung(30)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	75						CACCTGTCCCGGCTCTGGCTC	0.622000													24	226					0	0	1	0	0
ZNF831	128611	broad.mit.edu	37	20	57767475	57767475	+	Silent	SNP	G	G	A			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr20:57767475G>A	ENST00000371030.2	+	1	1401	c.1401G>A	c.(1399-1401)ccG>ccA	p.P467P		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	467						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					GGAGGGCCCCGGGCCCCGTGC	0.662000													6	72					0	0	1	0	0
VRK2	7444	broad.mit.edu	37	2	58362327	58362327	+	Silent	SNP	C	C	T			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr2:58362327C>T	ENST00000435505.2	+	13	1594	c.849C>T	c.(847-849)agC>agT	p.S283S	VRK2_ENST00000417641.2_Silent_p.S283S|VRK2_ENST00000340157.4_Silent_p.S283S|VRK2_ENST00000440705.2_Silent_p.S260S|VRK2_ENST00000412104.2_Silent_p.S283S			Q86Y07	VRK2_HUMAN	vaccinia related kinase 2	283	Protein kinase.					integral to membrane	ATP binding|protein binding|protein serine/threonine kinase activity			endometrium(4)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)	24						CTTCTGGAAGCAGTTGCTGTA	0.413000													22	121					0	0	1	0	0
ANKRD19P	138649	broad.mit.edu	37	9	95599380	95599380	+	RNA	SNP	C	C	A			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr9:95599380C>A	ENST00000473204.1	+	0	1461																											GCCACCAGTTCAGGCTTCTTG	0.592000													9	54					2.17888e-05	2.26333e-05	1	1	0
CLDN25	644672	broad.mit.edu	37	11	113650687	113650687	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr11:113650687G>A	ENST00000453129.2	+	1	219	c.170G>A	c.(169-171)cGa>cAa	p.R57Q		NM_001101389.1	NP_001094859.1	C9JDP6	CLD25_HUMAN	claudin 25	57						integral to membrane|tight junction	structural molecule activity			large_intestine(1)|lung(6)|ovary(1)|urinary_tract(2)	10						TGCGTGGATCGAGAGGAAGTC	0.562000													13	150					0	0	1	0	0
NBEAL1	65065	broad.mit.edu	37	2	204039938	204039938	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr2:204039938C>T	ENST00000449802.1	+	41	6638	c.6305C>T	c.(6304-6306)tCt>tTt	p.S2102F		NM_001114132.1	NP_001107604.1	Q6ZS30	NBEL1_HUMAN	neurobeachin-like 1	2102	BEACH.						binding			NS(1)|breast(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(8)|liver(1)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37						TATTCAAATTCTGCGGGGGTC	0.378000													8	55					0	0	1	0	0
CA3	761	broad.mit.edu	37	8	86360302	86360302	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr8:86360302G>T	ENST00000285381.2	+	7	786	c.703G>T	c.(703-705)Gag>Tag	p.E235*	RP11-317J10.2_ENST00000521761.1_RNA|RP11-317J10.2_ENST00000517697.1_RNA	NM_005181.3	NP_005172.1	P07451	CAH3_HUMAN	carbonic anhydrase III, muscle specific	235					one-carbon metabolic process	cytoplasm	carbonate dehydratase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23						TGCTGAGAACGAGCCCCCAGT	0.557000													7	45					8.12818e-05	8.31433e-05	1	1	0
MEX3D	399664	broad.mit.edu	37	19	1556649	1556649	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr19:1556649C>T	ENST00000402693.4	-	2	868	c.869G>A	c.(868-870)gGg>gAg	p.G290E	MEX3D_ENST00000388824.6_Missense_Mutation_p.G290E|AC027307.1_ENST00000410788.1_RNA	NM_203304.3	NP_976049.3	Q86XN8	MEX3D_HUMAN	mex-3 RNA binding family member D	290	KH 2.				mRNA destabilization|posttranscriptional regulation of gene expression by mRNA localization|regulation of anti-apoptosis	nucleus|perinuclear region of cytoplasm	AU-rich element binding|zinc ion binding			endometrium(1)|lung(3)	4		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCCTTGGGCCCCACCACCAG	0.726000													11	30					0	0	1	0	0
NPEPPS	9520	broad.mit.edu	37	17	45608813	45608813	+	Missense_Mutation	SNP	G	G	T			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr17:45608813G>T	ENST00000322157.4	+	1	384	c.147G>T	c.(145-147)agG>agT	p.R49S	NPEPPS_ENST00000530173.1_Missense_Mutation_p.R45S|NPEPPS_ENST00000525037.1_Intron|NPEPPS_ENST00000544660.1_Missense_Mutation_p.R5S	NM_006310.3	NP_006301.3	P55786	PSA_HUMAN	aminopeptidase puromycin sensitive	49					proteolysis	cytosol|nucleus	aminopeptidase activity|metallopeptidase activity|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(6)|lung(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	27						CGGAGAAGAGGCCCTTCGAGC	0.677000													4	7					0.150653	0.150653	1	1	0
MATR3	9782	broad.mit.edu	37	5	138661938	138661938	+	Missense_Mutation	SNP	C	C	A			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr5:138661938C>A	ENST00000394800.2	+	18	3151	c.2602C>A	c.(2602-2604)Cat>Aat	p.H868N	MATR3_ENST00000502929.1_Missense_Mutation_p.H868N|MATR3_ENST00000504203.1_Missense_Mutation_p.H482N|MATR3_ENST00000361059.2_Missense_Mutation_p.H820N|MATR3_ENST00000503811.1_Missense_Mutation_p.H532N|MATR3_ENST00000510056.1_Intron|MATR3_ENST00000509990.1_Missense_Mutation_p.H820N|MATR3_ENST00000394805.3_Missense_Mutation_p.H820N|MATR3_ENST00000502499.1_Missense_Mutation_p.H482N			P43243	MATR3_HUMAN	matrin 3	820						nuclear inner membrane|nuclear matrix	nucleotide binding|protein binding|RNA binding|structural molecule activity|zinc ion binding			breast(2)|endometrium(3)|kidney(4)|large_intestine(6)|lung(9)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	29			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			AAAGAATACTCATTGCAGCAG	0.328000													3	19					0.150653	0.150653	1	1	0
RDX	5962	broad.mit.edu	37	11	110102759	110102759	+	Splice_Site	SNP	C	C	T			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr11:110102759C>T	ENST00000343115.4	-	14	1907		c.e14-1		RDX_ENST00000544551.1_Splice_Site|RDX_ENST00000528900.1_Splice_Site|RDX_ENST00000530301.1_Intron|RDX_ENST00000405097.1_Splice_Site|RDX_ENST00000528498.1_Splice_Site	NM_001260494.1|NM_002906.3	NP_001247423.1|NP_002897.1	P35241	RADI_HUMAN	radixin						actin filament capping	cleavage furrow|cytoskeleton|extrinsic to membrane|Golgi apparatus|nucleolus|plasma membrane	actin binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(8)|skin(1)|urinary_tract(1)	18		all_cancers(61;7.18e-13)|all_epithelial(67;2.61e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;1.13e-06)|BRCA - Breast invasive adenocarcinoma(274;9.75e-06)|all cancers(92;5.9e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0248)		AACTTAATGCCtatttaaaaa	0.279000													17	96					0	0	1	0	0
TERF2	7014	broad.mit.edu	37	16	69400744	69400744	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr16:69400744G>C	ENST00000254942.3	-	7	1322	c.1306C>G	c.(1306-1308)Ctc>Gtc	p.L436V	TERF2_ENST00000603068.1_Missense_Mutation_p.L394V	NM_005652.3	NP_005643.2	Q15554	TERF2_HUMAN	telomeric repeat binding factor 2	394					age-dependent telomere shortening|cell cycle|cellular senescence|negative regulation of telomere maintenance via semi-conservative replication|protection from non-homologous end joining at telomere|protein localization to chromosome, telomeric region|regulation of transcription, DNA-dependent|telomeric loop formation	Golgi apparatus|nuclear telomere cap complex|nucleoplasm	double-stranded telomeric DNA binding|protein C-terminus binding|protein homodimerization activity			NS(2)|breast(1)|large_intestine(3)|lung(1)	7		Ovarian(137;0.101)				GGTTGGTTGAGAACGGTGGGC	0.562000													4	41					0	0	1	0	0
ALDH9A1	223	broad.mit.edu	37	1	165638641	165638641	+	Missense_Mutation	SNP	T	T	C			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr1:165638641T>C	ENST00000354775.4	-	7	1281	c.977A>G	c.(976-978)gAt>gGt	p.D326G	ALDH9A1_ENST00000538148.1_Missense_Mutation_p.D232G	NM_000696.3	NP_000687.3	P49189	AL9A1_HUMAN	aldehyde dehydrogenase 9 family, member A1	302					carnitine biosynthetic process|cellular aldehyde metabolic process|hormone metabolic process|neurotransmitter biosynthetic process	cytosol|plasma membrane	3-chloroallyl aldehyde dehydrogenase activity|4-trimethylammoniobutyraldehyde dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|aminobutyraldehyde dehydrogenase activity			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(7)|prostate(1)|skin(2)|urinary_tract(1)	21	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				NADH(DB00157)	TGTAAATTTATCAAGAATTTC	0.398000													7	61					0	0	1	0	0
NUMA1	4926	broad.mit.edu	37	11	71725814	71725814	+	Missense_Mutation	SNP	G	G	C			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr11:71725814G>C	ENST00000393695.3	-	15	3066	c.2735C>G	c.(2734-2736)aCc>aGc	p.T912S	RP11-849H4.4_ENST00000502284.1_RNA|NUMA1_ENST00000358965.6_Missense_Mutation_p.T912S|NUMA1_ENST00000351960.6_Intron	NM_006185.2	NP_006176.2	Q14980	NUMA1_HUMAN	nuclear mitotic apparatus protein 1	912					G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(12)|lung(20)|ovary(5)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	65						CTCTTTGCTGGTGGCAGCCAT	0.607000			T	RARA	APL								118	111					0	0	1	0	0
PITPNM2	57605	broad.mit.edu	37	12	123481122	123481122	+	Silent	SNP	G	G	A			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr12:123481122G>A	ENST00000280562.5	-	12	1870	c.1665C>T	c.(1663-1665)gtC>gtT	p.V555V	PITPNM2_ENST00000392428.1_Silent_p.V276V|PITPNM2_ENST00000542749.1_Silent_p.V555V|PITPNM2_ENST00000320201.4_Silent_p.V555V			Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein, membrane-associated 2	555					metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			NS(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	39	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		CAATCAGGCAGACCTTGGGAG	0.657000													6	71					0	0	1	0	0
FZD4	8322	broad.mit.edu	37	11	86666010	86666010	+	Missense_Mutation	SNP	C	C	T	rs139401671	byFrequency	TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr11:86666010C>T	ENST00000531380.1	-	1	423	c.118G>A	c.(118-120)Gag>Aag	p.E40K		NM_012193.3	NP_036325.2	Q9ULV1	FZD4_HUMAN	frizzled family receptor 4	40	FZ.		E -> Q (in EVR1).		canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|negative regulation of cell-substrate adhesion|neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|progesterone secretion|regulation of vascular endothelial growth factor receptor signaling pathway|substrate adhesion-dependent cell spreading|vasculogenesis|Wnt receptor signaling pathway, calcium modulating pathway	cell projection|cell surface|cytoplasm	cytokine binding|G-protein coupled receptor activity|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|Wnt receptor activity|Wnt-protein binding			breast(1)|kidney(1)|large_intestine(3)|lung(9)|prostate(6)|skin(1)	21		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				CGCTCTTCCTCGTCCCCGAAG	0.697000													4	45					0	0	1	0	0
APOL5	80831	broad.mit.edu	37	22	36122515	36122515	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr22:36122515C>T	ENST00000249044.2	+	3	400	c.400C>T	c.(400-402)Ctt>Ttt	p.L134F		NM_030642.1	NP_085145.1	Q9BWW9	APOL5_HUMAN	apolipoprotein L, 5	134					lipid metabolic process|lipid transport|lipoprotein metabolic process	cytoplasm|extracellular region	high-density lipoprotein particle binding|lipid binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(6)|skin(2)|urinary_tract(1)	19						TCACGAGTTGCTTACCAAGAC	0.502000													9	124					0	0	1	0	0
COPS6	10980	broad.mit.edu	37	7	99689087	99689087	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr7:99689087C>G	ENST00000303904.3	+	9	824	c.787C>G	c.(787-789)Ctg>Gtg	p.L263V	COPS6_ENST00000418625.1_Missense_Mutation_p.L262V	NM_006833.4	NP_006824.2	Q7L5N1	CSN6_HUMAN	COP9 signalosome subunit 6	263	Interaction with Vpr.				cullin deneddylation|interspecies interaction between organisms	cytoplasm|signalosome	protein binding			breast(1)|endometrium(3)|large_intestine(4)|lung(2)|prostate(1)|stomach(1)	12	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)		STAD - Stomach adenocarcinoma(171;0.129)			GGCCTATGCTCTGTGTCACTG	0.507000													33	130					0	0	1	0	0
PWWP2B	170394	broad.mit.edu	37	10	134230574	134230574	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr10:134230574G>A	ENST00000368609.4	+	3	1525	c.1496G>A	c.(1495-1497)cGa>cAa	p.R499Q	PWWP2B_ENST00000305233.5_3'UTR	NM_001098637.1	NP_001092107.1	Q6NUJ5	PWP2B_HUMAN	PWWP domain containing 2B	0	PWWP.									central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(5)|urinary_tract(1)	9		all_cancers(35;6.69e-12)|all_epithelial(44;1.55e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Breast(234;0.106)|Colorectal(31;0.109)|Melanoma(40;0.123)|Glioma(114;0.203)|all_hematologic(284;0.224)		OV - Ovarian serous cystadenocarcinoma(35;7.49e-05)|Epithelial(32;0.00016)|all cancers(32;0.000186)		GGTCACCGACGATGAGGGCGC	0.632000													69	364					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152324558	152324559	+	Frame_Shift_Del	DEL	TG	TG	-	rs140875805	byFrequency	TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr1:152324558_152324559delTG	ENST00000388718.5	-	3	5775_5776	c.5703_5704delCA	c.(5701-5706)cagcfs	p.HS1901fs	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000445097.1_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	1901							calcium ion binding|structural molecule activity	p.H1901fs*30(1)		NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGGCTTGGCTGTGTGTGTGTC	0.515													8	467	---	---	---	---					
PROX1	5629	broad.mit.edu	37	1	214170981	214170981	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr1:214170981delT	ENST00000366958.4	+	2	1711	c.1103delT	c.(1102-1104)gcfs	p.V368fs	PROX1_ENST00000498508.2_Frame_Shift_Del_p.V368fs|PROX1_ENST00000261454.4_Frame_Shift_Del_p.V368fs|PROX1_ENST00000435016.1_Frame_Shift_Del_p.V368fs	NM_001270616.1	NP_001257545.1	Q92786	PROX1_HUMAN	prospero homeobox 1	368					aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of S phase of mitotic cell cycle|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(3)|prostate(2)|skin(4)	47				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)		GACACTGTGGTCAAAGTCTTT	0.532													9	160	---	---	---	---					
OTOP1	133060	broad.mit.edu	37	4	4204225	4204229	+	Frame_Shift_Del	DEL	TTGAG	TTGAG	-			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr4:4204225_4204229delTTGAG	ENST00000296358.4	-	4	700_704	c.676_680delCTCAA	c.(676-681)tfs	p.LN226fs		NM_177998.1	NP_819056.1	Q7RTM1	OTOP1_HUMAN	otopetrin 1	226					biomineral tissue development	extracellular space|integral to membrane		p.L226fs*1(1)		NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(3)|liver(4)|lung(14)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	34				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		CTTGTGCTCATTGAGTTGGTGCTTT	0.502													7	144	---	---	---	---					
NLRC3	197358	broad.mit.edu	37	16	3594163	3594163	+	RNA	DEL	A	A	-	rs60164526		TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr16:3594163delA	ENST00000301749.7	-	0	3261				NLRC3_ENST00000603507.1_RNA|NLRC3_ENST00000448023.2_RNA|NLRC3_ENST00000419350.2_RNA|NLRC3_ENST00000359128.5_RNA	NM_178844.2	NP_849172.2	Q7RTR2	NLRC3_HUMAN	NLR family, CARD domain containing 3						I-kappaB kinase/NF-kappaB cascade|negative regulation of NF-kappaB transcription factor activity|T cell activation	cytoplasm	ATP binding			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(1)|liver(1)|lung(16)|ovary(2)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						tgtctcgaggaaaaaaaaaaa	0.488													4	5	---	---	---	---					
CNDP2	55748	broad.mit.edu	37	18	72173115	72173119	+	Frame_Shift_Del	DEL	CTATT	CTATT	-			TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr18:72173115_72173119delCTATT	ENST00000324262.4	+	4	552_556	c.236_240delCTATT	c.(235-240)cfs	p.PI79fs	CNDP2_ENST00000579847.1_Frame_Shift_Del_p.PI79fs|CNDP2_ENST00000324301.8_Intron	NM_018235.2	NP_060705.2	Q96KP4	CNDP2_HUMAN	CNDP dipeptidase 2 (metallopeptidase M20 family)	79						cytoplasm	carboxypeptidase activity|metal ion binding|metallopeptidase activity|protein binding|tripeptidase activity			breast(1)|cervix(1)|endometrium(3)|large_intestine(7)|lung(5)|ovary(2)|skin(2)|stomach(3)	24		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.22)		CCGCTCCCTCCTATTCTGCTCGGCA	0.576													8	48	---	---	---	---					
ZNF761	388561	broad.mit.edu	37	19	53946133	53946133	+	RNA	DEL	A	A	-	rs35108555		TCGA-BB-8596-01A-11D-2394-08	TCGA-BB-8596-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	77ded927-d328-4fbd-a9b6-22186c6e8d16	2c431744-ff25-4064-933b-53037e011d1e	g.chr19:53946133delA	ENST00000454407.1	+	0	55				TPM3P9_ENST00000424846.3_RNA			Q86XN6	ZN761_HUMAN	zinc finger protein 761						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	30				GBM - Glioblastoma multiforme(134;0.00786)		TCATGTTGTGAAAAAAAAAAT	0.348													4	3	---	---	---	---