Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
GUSB	2990	broad.mit.edu	37	7	65426002	65426002	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr7:65426002C>G	ENST00000304895.4	-	12	1968	c.1838G>C	c.(1837-1839)aGa>aCa	p.R613T	GUSB_ENST00000345660.6_Missense_Mutation_p.R562T|GUSB_ENST00000421103.1_Missense_Mutation_p.R467T	NM_000181.3	NP_000172.2	P08236	BGLR_HUMAN	glucuronidase, beta	613					glycosaminoglycan catabolic process	lysosome	beta-glucuronidase activity|cation binding			breast(1)|cervix(2)|kidney(2)|large_intestine(4)|lung(10)|skin(1)	20						TTTTGGTTGTCTCTGCCGAGT	0.448000													27	198					0	0	1	0	0
BARD1	580	broad.mit.edu	37	2	215617235	215617235	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr2:215617235C>A	ENST00000260947.4	-	7	1747	c.1613G>T	c.(1612-1614)aGt>aTt	p.S538I	BARD1_ENST00000449967.2_Missense_Mutation_p.S394I	NM_000465.2	NP_000456.2	Q99728	BARD1_HUMAN	BRCA1 associated RING domain 1	538					cell cycle arrest|DNA repair|negative regulation of apoptosis|negative regulation of mRNA 3'-end processing|negative regulation of protein export from nucleus|positive regulation of apoptosis|positive regulation of protein catabolic process|protein K6-linked ubiquitination|regulation of phosphorylation|tissue homeostasis	BRCA1-A complex|BRCA1-BARD1 complex|cytoplasm	kinase binding|protein heterodimerization activity|protein homodimerization activity|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			NS(2)|breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(14)|prostate(4)|upper_aerodigestive_tract(1)	35		Renal(323;0.0243)		Epithelial(149;3.2e-06)|all cancers(144;0.000461)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		CGATTTCATACTTTCATCATC	0.373000									Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				7	74					1.12685e-05	1.22545e-05	1	1	0
FGD6	55785	broad.mit.edu	37	12	95604446	95604446	+	Missense_Mutation	SNP	C	C	A	rs146520684		TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr12:95604446C>A	ENST00000343958.4	-	2	837	c.614G>T	c.(613-615)aGc>aTc	p.S205I	FGD6_ENST00000549499.1_Missense_Mutation_p.S205I|FGD6_ENST00000546711.1_Missense_Mutation_p.S205I	NM_018351.3	NP_060821.3	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	205					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			breast(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(14)|liver(1)|lung(12)|ovary(3)|prostate(3)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	56						CATTTCTGGGCTGTCTGTGGG	0.418000													7	85					2.7689e-08	3.16966e-08	1	1	0
LOC101927209	101927209	broad.mit.edu	37	1	142713773	142713773	+	RNA	SNP	C	C	G			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr1:142713773C>G	ENST00000369381.2	-	0	832																											TCTTTTTCCACATTGTCATTT	0.284000													3	64					0	0	1	0	0
KCNH7	90134	broad.mit.edu	37	2	163360993	163360993	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr2:163360993A>G	ENST00000332142.5	-	6	1187	c.1088T>C	c.(1087-1089)gTt>gCt	p.V363A	KCNH7_ENST00000477019.1_5'UTR|KCNH7_ENST00000328032.4_Missense_Mutation_p.V356A	NM_033272.3	NP_150375.2	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 7	363					regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(22)|lung(53)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	108					Ibutilide(DB00308)	TCGATCTTTAACCTTGGGTGC	0.373000													17	130					0	0	1	0	0
TRPV2	51393	broad.mit.edu	37	17	16336965	16336965	+	Silent	SNP	C	C	T			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr17:16336965C>T	ENST00000338560.7	+	13	2466	c.2067C>T	c.(2065-2067)acC>acT	p.T689T	TRPV2_ENST00000577397.1_Silent_p.T259T	NM_016113.4	NP_057197.2	Q9Y5S1	TRPV2_HUMAN	transient receptor potential cation channel, subfamily V, member 2	689					sensory perception	integral to plasma membrane|melanosome	calcium channel activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(9)|ovary(1)|pancreas(1)|prostate(2)|stomach(3)	28				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		TGATGCTGACCGTTGGCACTA	0.587000													32	90					0	0	1	0	0
CCDC84	338657	broad.mit.edu	37	11	118881943	118881943	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr11:118881943A>G	ENST00000334418.1	+	5	519	c.463A>G	c.(463-465)Atc>Gtc	p.I155V	CCDC84_ENST00000580556.1_3'UTR	NM_198489.1	NP_940891.1	Q86UT8	CCD84_HUMAN	coiled-coil domain containing 84	155										breast(1)|kidney(1)|large_intestine(1)|liver(1)|ovary(1)	5	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0523)|all_neural(223;0.224)|all_hematologic(192;0.243)		BRCA - Breast invasive adenocarcinoma(274;7.72e-05)		GGCAGCTCAGATCCGTGAGGT	0.562000													7	52					0	0	1	0	0
TXNDC9	10190	broad.mit.edu	37	2	99944026	99944026	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr2:99944026A>T	ENST00000264255.3	-	3	535	c.280T>A	c.(280-282)Tgc>Agc	p.C94S	TXNDC9_ENST00000409434.1_Missense_Mutation_p.C94S	NM_005783.3	NP_005774.2	O14530	TXND9_HUMAN	thioredoxin domain containing 9	94	Thioredoxin.				cell redox homeostasis		protein binding			lung(1)	1						TAGAAATGGCAAACCACATTT	0.378000													5	41					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577120	7577120	+	Missense_Mutation	SNP	C	C	T	rs28934576	by1000genomes	TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr17:7577120C>T	ENST00000420246.2	-	8	950	c.818G>A	c.(817-819)cGt>cAt	p.R273H	TP53_ENST00000445888.2_Missense_Mutation_p.R273H|TP53_ENST00000269305.4_Missense_Mutation_p.R273H|TP53_ENST00000413465.2_Intron|TP53_ENST00000455263.2_Missense_Mutation_p.R273H|TP53_ENST00000359597.4_Missense_Mutation_p.R273H	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	273	Interaction with AXIN1 (By similarity).|Interaction with DNA.|Interaction with E4F1.|Interaction with HIPK1 (By similarity).		R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> H (in LFS; germline mutation and in sporadic cancers; somatic mutation; abolishes sequence-specific DNA binding; dbSNP:rs28934576).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273H(521)|p.R273L(93)|p.R273P(32)|p.0?(8)|p.?(2)|p.R273fs*32(2)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.R273S(1)|p.E258fs*71(1)|p.R273fs*72(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.R273fs*33(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCACAAACACGCACCTCAAA	0.542000	R273H(EN_ENDOMETRIUM)|R273H(HEC59_ENDOMETRIUM)|R273H(HEC6_ENDOMETRIUM)|R273H(HT29_LARGE_INTESTINE)|R273H(HT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(MDAMB468_BREAST)|R273H(MOLT13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(NCIH1155_LUNG)|R273H(NCIH1793_LUNG)|R273H(NCIH1975_LUNG)|R273H(NCIH2405_LUNG)|R273H(NCIH508_LARGE_INTESTINE)|R273H(OC314_OVARY)|R273H(PANC1_PANCREAS)|R273H(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SKMEL30_SKIN)|R273H(SNB19_CENTRAL_NERVOUS_SYSTEM)|R273H(SUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SUIT2_PANCREAS)|R273H(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273H(SW480_LARGE_INTESTINE)|R273H(SW620_LARGE_INTESTINE)|R273H(U251MG_CENTRAL_NERVOUS_SYSTEM)	111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			8	16					0	0	1	0	0
PTPRE	5791	broad.mit.edu	37	10	129877893	129877893	+	Silent	SNP	A	A	C	rs17854594		TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr10:129877893A>C	ENST00000254667.3	+	20	2241	c.1962A>C	c.(1960-1962)ggA>ggC	p.G654G	PTPRE_ENST00000419012.2_Silent_p.G654G|PTPRE_ENST00000306042.5_Silent_p.G596G	NM_006504.4	NP_006495.1	P23469	PTPRE_HUMAN	protein tyrosine phosphatase, receptor type, E	654	Tyrosine-protein phosphatase 2.				negative regulation of insulin receptor signaling pathway|protein phosphorylation	cytoplasm|integral to membrane|intermediate filament cytoskeleton|nucleus|plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	22		all_epithelial(44;1.66e-05)|all_lung(145;0.00456)|Lung NSC(174;0.0066)|all_neural(114;0.0936)|Colorectal(57;0.141)|Breast(234;0.166)|Melanoma(40;0.203)				AAGCCGAGGGACTTTTAGATG	0.448000													5	46					0	0	1	0	0
OR10K2	391107	broad.mit.edu	37	1	158389942	158389942	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr1:158389942A>G	ENST00000314902.2	-	1	714	c.715T>C	c.(715-717)Tct>Cct	p.S239P		NM_001004476.1	NP_001004476.1	Q6IF99	O10K2_HUMAN	olfactory receptor, family 10, subfamily K, member 2	239					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(19)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36	all_hematologic(112;0.0378)					ACACAGGTAGAAAAAGCTTTG	0.473000													6	85					0	0	1	0	0
MMP15	4324	broad.mit.edu	37	16	58071493	58071493	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr16:58071493G>C	ENST00000219271.3	+	2	1065	c.280G>C	c.(280-282)Gtc>Ctc	p.V94L		NM_002428.2	NP_002419.1	P51511	MMP15_HUMAN	matrix metallopeptidase 15 (membrane-inserted)	94					protein modification process|proteolysis	extracellular matrix|integral to plasma membrane	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|protein binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	18						CGGGATCCCAGTCACCGGTGT	0.627000													8	93					0	0	1	0	0
FAM218A	152756	broad.mit.edu	37	4	165878636	165878636	+	Silent	SNP	A	A	G			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr4:165878636A>G	ENST00000513876.2	+	1	537	c.462A>G	c.(460-462)tcA>tcG	p.S154S	TRIM61_ENST00000329314.5_Intron	NM_153027.1	NP_694572.1	Q96MZ4	CD039_HUMAN	family with sequence similarity 218, member A	154																	CGCTGGGCTCACCTGTCCTAT	0.498000													7	39					0	0	1	0	0
LRRC45	201255	broad.mit.edu	37	17	79985312	79985312	+	Silent	SNP	G	G	A			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr17:79985312G>A	ENST00000306688.3	+	7	1167	c.825G>A	c.(823-825)aaG>aaA	p.K275K		NM_144999.2	NP_659436.1	Q96CN5	LRC45_HUMAN	leucine rich repeat containing 45	275						centrosome				lung(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	5	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0191)			AGATGGCCAAGAGCAGCAGGT	0.617000													12	90					0	0	1	0	0
CHRNG	1146	broad.mit.edu	37	2	233409224	233409224	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr2:233409224C>T	ENST00000389494.3	+	10	1204	c.1183C>T	c.(1183-1185)Cgc>Tgc	p.R395C	CHRNG_ENST00000389492.3_Missense_Mutation_p.R343C	NM_005199.4	NP_005190.4	P07510	ACHG_HUMAN	cholinergic receptor, nicotinic, gamma (muscle)	395					muscle contraction	cell junction|postsynaptic membrane	acetylcholine receptor activity			breast(2)|endometrium(3)|large_intestine(4)|lung(12)|upper_aerodigestive_tract(1)	22		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;6.39e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00079)|LUSC - Lung squamous cell carcinoma(224;0.00757)|Lung(119;0.0086)		CTGCCTGCCTCGCAGTGAACT	0.657000													12	108					0	0	1	0	0
TRIM38	10475	broad.mit.edu	37	6	25983471	25983471	+	Silent	SNP	C	C	T			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr6:25983471C>T	ENST00000357085.3	+	8	1430	c.954C>T	c.(952-954)taC>taT	p.Y318Y	TRIM38_ENST00000349458.3_Silent_p.Y318Y	NM_006355.3	NP_006346.1	O00635	TRI38_HUMAN	tripartite motif containing 38	318	B30.2/SPRY.				positive regulation of I-kappaB kinase/NF-kappaB cascade	intracellular	signal transducer activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(8)|upper_aerodigestive_tract(2)	23						CTCGTGGATACACCCAGGAGA	0.463000													9	54					0	0	1	0	0
RECK	8434	broad.mit.edu	37	9	36058859	36058859	+	Missense_Mutation	SNP	T	T	G			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr9:36058859T>G	ENST00000377966.3	+	3	761	c.195T>G	c.(193-195)caT>caG	p.H65Q	RECK_ENST00000479053.1_3'UTR	NM_021111.2	NP_066934.1	O95980	RECK_HUMAN	reversion-inducing-cysteine-rich protein with kazal motifs	65	5 X Knot repeats.					anchored to membrane|peripheral to membrane of membrane fraction|plasma membrane	metalloendopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(7)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|pancreas(1)|skin(2)|stomach(1)	32			LUSC - Lung squamous cell carcinoma(32;0.112)|STAD - Stomach adenocarcinoma(86;0.228)			GACTAAAACATCTGTTGCAGC	0.328000													7	45					0	0	1	0	0
PFKFB3	5209	broad.mit.edu	37	10	6265929	6265929	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr10:6265929C>T	ENST00000379775.4	+	12	1552	c.1222C>T	c.(1222-1224)Ccc>Tcc	p.P408S	PFKFB3_ENST00000360521.2_Missense_Mutation_p.P408S|PFKFB3_ENST00000540253.1_Missense_Mutation_p.P422S|PFKFB3_ENST00000317350.4_Missense_Mutation_p.P408S|PFKFB3_ENST00000536985.1_3'UTR|PFKFB3_ENST00000379785.1_Missense_Mutation_p.P408S|PFKFB3_ENST00000379782.3_Missense_Mutation_p.P408S|PFKFB3_ENST00000379789.4_Missense_Mutation_p.P388S	NM_004566.3	NP_004557.1	Q16875	F263_HUMAN	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	408	Fructose-2,6-bisphosphatase.				fructose 2,6-bisphosphate metabolic process|glycolysis	cytosol	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity|identical protein binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(1)|liver(2)|lung(10)|ovary(3)|upper_aerodigestive_tract(1)	22						AGAGGAGATGCCCTACCTGAA	0.562000													4	164					0	0	1	0	0
STAR	6770	broad.mit.edu	37	8	38006158	38006158	+	Splice_Site	SNP	C	C	T			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr8:38006158C>T	ENST00000276449.4	-	2	625		c.e2+1			NM_000349.2	NP_000340.2	P49675	STAR_HUMAN	steroidogenic acute regulatory protein						C21-steroid hormone biosynthetic process	mitochondrial intermembrane space	cholesterol transporter activity			breast(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|skin(1)	11	Colorectal(12;0.000442)	all_lung(54;0.0151)|Lung NSC(58;0.0295)		READ - Rectum adenocarcinoma(644;0.188)		TCAGCACTTACCGAGTAGAGA	0.637000													8	52					0	0	1	0	0
DHX33	56919	broad.mit.edu	37	17	5347733	5347733	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr17:5347733C>G	ENST00000225296.3	-	12	2116	c.1916G>C	c.(1915-1917)gGc>gCc	p.G639A	DHX33_ENST00000433302.3_Missense_Mutation_p.G415A	NM_001199699.1|NM_020162.3	NP_001186628.1|NP_064547.2	Q9H6R0	DHX33_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 33	639						nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						GGCATAGGTGCCATCTGGCTG	0.622000													10	60					0	0	1	0	0
CNTRL	11064	broad.mit.edu	37	9	123914807	123914807	+	Silent	SNP	A	A	G			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr9:123914807A>G	ENST00000373855.1	+	26	4268	c.4008A>G	c.(4006-4008)aaA>aaG	p.K1336K	CNTRL_ENST00000373845.2_3'UTR|CNTRL_ENST00000373850.1_Silent_p.K784K|CNTRL_ENST00000373847.1_Silent_p.K784K|CNTRL_ENST00000238341.5_Silent_p.K1336K			Q7Z7A1	CNTRL_HUMAN	centriolin	1336					cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding			haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(2)|ovary(4)|skin(3)	20						AGCATTTAAAATCAAAGAAGC	0.398000													7	105					0	0	1	0	0
OLFM2	93145	broad.mit.edu	37	19	9965152	9965152	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr19:9965152G>A	ENST00000264833.4	-	6	1260	c.1075C>T	c.(1075-1077)Cgg>Tgg	p.R359W	OLFM2_ENST00000590841.1_Missense_Mutation_p.R281W	NM_058164.2	NP_477512.1	O95897	NOE2_HUMAN	olfactomedin 2	359	Olfactomedin-like.					extracellular region				breast(1)|cervix(1)|endometrium(3)|large_intestine(8)|lung(9)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)	31						TCCCAGGACCGCATGACCTCG	0.657000													4	116					0	0	1	0	0
RUNX2	860	broad.mit.edu	37	6	45459744	45459744	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr6:45459744G>A	ENST00000371438.1	+	5	1110	c.752G>A	c.(751-753)cGc>cAc	p.R251H	RUNX2_ENST00000359524.5_Missense_Mutation_p.R237H|RUNX2_ENST00000576263.1_Missense_Mutation_p.R251H|RUNX2_ENST00000541979.1_Missense_Mutation_p.R319H|RUNX2_ENST00000371436.6_Missense_Mutation_p.R251H|RUNX2_ENST00000371432.3_Missense_Mutation_p.R237H|RUNX2_ENST00000465038.2_Missense_Mutation_p.R251H|RUNX2_ENST00000352853.5_Missense_Mutation_p.R319H	NM_001024630.3	NP_001019801.3	Q13950	RUNX2_HUMAN	runt-related transcription factor 2	251	Pro/Ser/Thr-rich.				negative regulation of transcription, DNA-dependent|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(18)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34						GATTTAGGGCGCATTCCTCAT	0.473000													4	156					0	0	1	0	0
RPS6KA1	6195	broad.mit.edu	37	1	26887589	26887589	+	Silent	SNP	G	G	T			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr1:26887589G>T	ENST00000374168.2	+	16	1549	c.1395G>T	c.(1393-1395)cgG>cgT	p.R465R	RPS6KA1_ENST00000374166.4_Silent_p.R454R|RPS6KA1_ENST00000526792.1_Silent_p.R373R|RPS6KA1_ENST00000374162.2_Silent_p.R373R|RPS6KA1_ENST00000531382.1_Silent_p.R474R|RPS6KA1_ENST00000530003.1_Silent_p.R449R	NM_002953.3	NP_002944.2	Q15418	KS6A1_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 1	465	Protein kinase 2.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein binding|protein serine/threonine kinase activity			lung(1)	1		all_cancers(24;2.49e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00571)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;1.12e-50)|OV - Ovarian serous cystadenocarcinoma(117;2.89e-29)|Colorectal(126;1.4e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000537)|KIRC - Kidney renal clear cell carcinoma(1967;0.000759)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0361)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.161)|LUSC - Lung squamous cell carcinoma(448;0.234)		TTCTTCTGCGGTATGGCCAGC	0.527000													4	48					0.00909568	0.00942053	1	1	0
FASN	2194	broad.mit.edu	37	17	80040889	80040889	+	Missense_Mutation	SNP	C	C	T	rs139792253		TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr17:80040889C>T	ENST00000306749.2	-	33	5886	c.5668G>A	c.(5668-5670)Gct>Act	p.A1890T	FASN_ENST00000579758.1_5'UTR	NM_004104.4	NP_004095.4	P49327	FAS_HUMAN	fatty acid synthase	1890	Beta-ketoacyl reductase (By similarity).				energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|pantothenate metabolic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	cytosol|Golgi apparatus|melanosome|plasma membrane	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|acyl carrier activity|cofactor binding|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|phosphopantetheine binding|protein binding|zinc ion binding			central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(12)|prostate(3)|skin(2)|urinary_tract(1)	34	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		OV - Ovarian serous cystadenocarcinoma(97;0.0211)|BRCA - Breast invasive adenocarcinoma(99;0.0237)		Cerulenin(DB01034)|Orlistat(DB01083)|Pyrazinamide(DB00339)	AGACCACCAGCGATGATGTAG	0.632000													5	61					0	0	1	0	0
GCOM1	145781	broad.mit.edu	37	15	57913834	57913834	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr15:57913834A>T	ENST00000574161.1	+	4	466	c.347A>T	c.(346-348)aAg>aTg	p.K116M	GCOM1_ENST00000380561.2_Intron|GCOM1_ENST00000380568.3_Missense_Mutation_p.K116M|GCOM1_ENST00000396180.1_Intron|MYZAP_ENST00000380565.4_Missense_Mutation_p.K116M|POLR2M_ENST00000380563.2_Intron|GCOM1_ENST00000587652.1_Missense_Mutation_p.K116M|GCOM1_ENST00000380560.2_Intron|GCOM1_ENST00000380569.2_Missense_Mutation_p.K116M|MYZAP_ENST00000267853.5_Missense_Mutation_p.K116M|GCOM1_ENST00000572390.1_Missense_Mutation_p.K116M	NM_001018100.3	NP_001018110.1	P0CAP1	GCOM1_HUMAN		116					intracellular signal transduction	extrinsic to internal side of plasma membrane|I band				endometrium(1)|kidney(2)|large_intestine(9)|liver(1)|lung(1)|ovary(1)|skin(2)|stomach(1)	18						AAGGTGAGAAAGCGAATGTAT	0.403000													10	80					0	0	1	0	0
FEZF1	389549	broad.mit.edu	37	7	121942264	121942264	+	Silent	SNP	G	G	A			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr7:121942264G>A	ENST00000442488.2	-	4	1282	c.1215C>T	c.(1213-1215)tgC>tgT	p.C405C	FEZF1_ENST00000427185.2_Silent_p.C355C|FEZF1_ENST00000331178.4_Silent_p.C401C	NM_001024613.2|NM_001160264.1	NP_001019784.2|NP_001153736.1	A0PJY2	FEZF1_HUMAN	FEZ family zinc finger 1	405					cell differentiation|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|large_intestine(3)|lung(18)|ovary(2)|prostate(1)	25						AACCCTTGCCGCACGTGGGGC	0.572000													4	123					0	0	1	0	0
STRADB	55437	broad.mit.edu	37	2	202337801	202337801	+	Splice_Site	SNP	T	T	A			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr2:202337801T>A	ENST00000194530.3	+	5	680		c.e5+2		STRADB_ENST00000392249.2_Splice_Site	NM_001206864.1|NM_018571.5	NP_001193793.1|NP_061041.2	Q9C0K7	STRAB_HUMAN	STE20-related kinase adaptor beta						activation of protein kinase activity|cell cycle arrest|insulin receptor signaling pathway|protein export from nucleus|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|protein binding|protein kinase activity			breast(1)|large_intestine(2)|lung(5)|prostate(1)|skin(3)|stomach(1)	13						GCTTTACAGGTAACAATATGA	0.368000													10	77					0	0	1	0	0
C9orf84	158401	broad.mit.edu	37	9	114520394	114520394	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr9:114520394C>A	ENST00000394779.3	-	3	613	c.369G>T	c.(367-369)gaG>gaT	p.E123D	C9orf84_ENST00000374283.5_Missense_Mutation_p.E226D|C9orf84_ENST00000374287.3_Missense_Mutation_p.E162D|C9orf84_ENST00000394777.4_Missense_Mutation_p.E123D|C9orf84_ENST00000318737.4_Missense_Mutation_p.E162D	NM_001080551.1	NP_001074020.1	Q5VXU9	CI084_HUMAN	chromosome 9 open reading frame 84	162										breast(1)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(10)|liver(1)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35						CTTCTAGTTTCTCTTGACAAA	0.269000													5	16					0.0215528	0.0220599	1	1	0
LCE1F	353137	broad.mit.edu	37	1	152748927	152748927	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr1:152748927C>A	ENST00000334371.2	+	1	80	c.80C>A	c.(79-81)cCg>cAg	p.P27Q		NM_178354.2	NP_848131.1	Q5T754	LCE1F_HUMAN	late cornified envelope 1F	27	Pro-rich.				keratinization					kidney(1)|large_intestine(2)|lung(7)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			tgccccacaccgaagtgcccc	0.657000													11	86					1.58986e-06	1.77331e-06	1	1	0
KIAA0195	9772	broad.mit.edu	37	17	73484066	73484066	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr17:73484066C>T	ENST00000314256.7	+	6	857	c.463C>T	c.(463-465)Ctc>Ttc	p.L155F	KIAA0195_ENST00000579208.1_Intron|KIAA0195_ENST00000583795.1_3'UTR|KIAA0195_ENST00000375248.5_Missense_Mutation_p.L165F	NM_014738.4	NP_055553.3	Q12767	K0195_HUMAN	KIAA0195	155					ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			breast(2)|endometrium(5)|kidney(2)|large_intestine(7)|lung(17)|ovary(5)|skin(2)|stomach(1)|urinary_tract(1)	42	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			GTATCCAGACCTCCACATGCC	0.587000													6	67					0	0	1	0	0
LARP1B	55132	broad.mit.edu	37	4	129043120	129043120	+	Missense_Mutation	SNP	A	A	C			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr4:129043120A>C	ENST00000326639.6	+	11	1512	c.1301A>C	c.(1300-1302)aAt>aCt	p.N434T	LARP1B_ENST00000512292.1_Missense_Mutation_p.N434T|LARP1B_ENST00000427266.1_Missense_Mutation_p.N434T|LARP1B_ENST00000264584.5_Missense_Mutation_p.N387T|LARP1B_ENST00000441387.1_Missense_Mutation_p.N434T|LARP1B_ENST00000354456.3_5'UTR	NM_018078.2	NP_060548.2	Q659C4	LAR1B_HUMAN	La ribonucleoprotein domain family, member 1B	434							RNA binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(7)|lung(11)|ovary(1)|prostate(3)	34						TGGTCTGATAATGATTCAGAT	0.333000													9	51					0	0	1	0	0
STRA6	64220	broad.mit.edu	37	15	74474544	74474544	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr15:74474544A>T	ENST00000323940.5	-	16	1723	c.1478T>A	c.(1477-1479)gTc>gAc	p.V493D	STRA6_ENST00000423167.2_Missense_Mutation_p.V484D|STRA6_ENST00000416286.3_Missense_Mutation_p.V485D|STRA6_ENST00000574439.1_5'UTR|STRA6_ENST00000563965.1_Missense_Mutation_p.V532D|STRA6_ENST00000574278.1_Missense_Mutation_p.V508D|STRA6_ENST00000535552.1_Missense_Mutation_p.V530D|STRA6_ENST00000395105.4_Missense_Mutation_p.V493D|STRA6_ENST00000449139.2_Missense_Mutation_p.V493D	NM_001142617.1|NM_001142618.1|NM_001142619.1	NP_001136089.1|NP_001136090.1|NP_001136091.1	Q9BX79	STRA6_HUMAN	stimulated by retinoic acid 6	493					adrenal gland development|alveolar primary septum development|developmental growth|diaphragm development|digestive tract morphogenesis|ear development|embryonic camera-type eye formation|embryonic digestive tract development|eyelid development in camera-type eye|face morphogenesis|feeding behavior|female genitalia development|kidney development|lung vasculature development|neuromuscular process|nose morphogenesis|paramesonephric duct development|positive regulation of behavior|pulmonary artery morphogenesis|pulmonary valve morphogenesis|smooth muscle tissue development|transport|uterus morphogenesis|ventricular septum development|vocal learning	integral to membrane|plasma membrane|protein complex	receptor activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(4)|lung(5)|skin(1)|stomach(2)	26						CTCCAGGAAGACCCAATGGGC	0.622000													8	72					0	0	1	0	0
NEUROG2	63973	broad.mit.edu	37	4	113436581	113436581	+	Silent	SNP	T	T	C			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr4:113436581T>C	ENST00000313341.3	-	2	377	c.51A>G	c.(49-51)ttA>ttG	p.L17L	RP11-402J6.1_ENST00000506057.1_RNA	NM_024019.3	NP_076924.1	Q9H2A3	NGN2_HUMAN	neurogenin 2	17					positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent	nucleus	E-box binding			central_nervous_system(1)|large_intestine(3)|lung(6)|skin(2)	12		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.00168)		CGAGCAGCACTAACACGTCCT	0.602000													11	36					0	0	1	0	0
NCOA3	8202	broad.mit.edu	37	20	46252789	46252789	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr20:46252789A>T	ENST00000372004.3	+	4	434	c.218A>T	c.(217-219)aAg>aTg	p.K73M	NCOA3_ENST00000371997.3_Missense_Mutation_p.K73M|NCOA3_ENST00000371998.3_Missense_Mutation_p.K73M|NCOA3_ENST00000341724.6_Missense_Mutation_p.K73M	NM_001174087.1|NM_001174088.1|NM_006534.3|NM_181659.2	NP_001167558.1|NP_001167559.1|NP_006525.2|NP_858045.1	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3	73	Helix-loop-helix motif.				androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			breast(3)|endometrium(3)|kidney(4)|large_intestine(12)|lung(19)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	52						GCGATTTTAAAGGAAACAGTA	0.358000													6	45					0	0	1	0	0
TGOLN2	10618	broad.mit.edu	37	2	85553654	85553654	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr2:85553654T>C	ENST00000377386.3	-	2	1663	c.1201A>G	c.(1201-1203)Atc>Gtc	p.I401V	TGOLN2_ENST00000282120.2_Missense_Mutation_p.I245V|TGOLN2_ENST00000409232.3_Missense_Mutation_p.I401V|TGOLN2_ENST00000444342.2_Missense_Mutation_p.I401V|TGOLN2_ENST00000409015.1_Missense_Mutation_p.I401V|TGOLN2_ENST00000398263.2_Missense_Mutation_p.I343V			O43493	TGON2_HUMAN	trans-golgi network protein 2	401						integral to membrane|nucleus|plasma membrane|trans-Golgi network|transport vesicle	protein binding										TGATGAGCGATATAGAGGACA	0.562000													14	76					0	0	1	0	0
SNX22	79856	broad.mit.edu	37	15	64446598	64446598	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr15:64446598A>G	ENST00000325881.4	+	7	532	c.473A>G	c.(472-474)aAc>aGc	p.N158S		NM_024798.2	NP_079074.2	Q96L94	SNX22_HUMAN	sorting nexin 22	158					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding			large_intestine(3)|lung(1)|urinary_tract(2)	6						TCGCTGCCCAACGTGGTGGTG	0.597000											OREG0023180	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	153					0	0	1	0	0
CFH	3075	broad.mit.edu	37	1	196659265	196659265	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr1:196659265C>G	ENST00000367429.4	+	9	1472	c.1232C>G	c.(1231-1233)tCt>tGt	p.S411C	CFH_ENST00000359637.2_Missense_Mutation_p.S347C|CFH_ENST00000439155.2_Missense_Mutation_p.S411C	NM_000186.3	NP_000177.2	P08603	CFAH_HUMAN	complement factor H	411	Sushi 7.				complement activation, alternative pathway	extracellular space				NS(3)|breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(24)|lung(33)|ovary(1)|prostate(5)|skin(9)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	101						CAGGGTAAATCTATAGACGTT	0.393000													4	40					0	0	1	0	0
SNRNP200	23020	broad.mit.edu	37	2	96953193	96953193	+	Silent	SNP	C	C	T			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr2:96953193C>T	ENST00000323853.5	-	26	3545	c.3468G>A	c.(3466-3468)ctG>ctA	p.L1156L	SNRNP200_ENST00000349783.5_Intron	NM_014014.4	NP_054733.2	O75643	U520_HUMAN	small nuclear ribonucleoprotein 200kDa (U5)	1156	SEC63 1.					catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|lung(37)|ovary(7)|prostate(4)|skin(5)|stomach(1)|urinary_tract(1)	90						CATTATGATTCAGGTCGTACA	0.517000													16	134					0	0	1	0	0
MPP5	64398	broad.mit.edu	37	14	67745984	67745984	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr14:67745984C>G	ENST00000261681.4	+	3	758	c.97C>G	c.(97-99)Cga>Gga	p.R33G	MPP5_ENST00000555925.1_5'UTR|MPP5_ENST00000556345.1_Missense_Mutation_p.R33G	NM_022474.3	NP_071919.2	Q8N3R9	MPP5_HUMAN	membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)	33	Interaction with PARD6B (By similarity).				tight junction assembly	cytoplasm|endomembrane system|tight junction	protein domain specific binding			cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(8)|ovary(1)|skin(1)	18				all cancers(60;0.000388)|OV - Ovarian serous cystadenocarcinoma(108;0.00762)|BRCA - Breast invasive adenocarcinoma(234;0.0106)		TCAGAAGCACCGAGAGATGGC	0.478000													4	56					0	0	1	0	0
C6orf89	221477	broad.mit.edu	37	6	36870018	36870018	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr6:36870018A>T	ENST00000480824.2	+	4	505	c.211A>T	c.(211-213)Atc>Ttc	p.I71F	C6orf89_ENST00000373685.1_Missense_Mutation_p.I71F|C6orf89_ENST00000355190.3_Missense_Mutation_p.I78F|C6orf89_ENST00000359359.2_5'UTR|C6orf89_ENST00000510325.2_Intron			Q6UWU4	CF089_HUMAN	chromosome 6 open reading frame 89	71						integral to membrane				breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(4)|ovary(1)|skin(2)	15						CTTGGGATTAATCTTGCTCAC	0.428000													11	91					0	0	1	0	0
TRGV2	6974	broad.mit.edu	37	7	38402656	38402656	+	RNA	SNP	G	G	T			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr7:38402656G>T	ENST00000426402.2	-	0	352																											TCCTGGTGTAGGTACCAGTGG	0.498000													12	71					9.31168e-06	1.02546e-05	1	1	0
CCDC101	112869	broad.mit.edu	37	16	28596281	28596281	+	Silent	SNP	C	C	T			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr16:28596281C>T	ENST00000317058.3	+	3	310	c.123C>T	c.(121-123)acC>acT	p.T41T		NM_138414.2	NP_612423.1	Q96ES7	SGF29_HUMAN	coiled-coil domain containing 101	41					establishment of protein localization to chromatin|histone H3 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ada2/Gcn5/Ada3 transcription activator complex|SAGA-type complex	methylated histone residue binding			central_nervous_system(2)|endometrium(1)|large_intestine(2)|lung(4)|skin(1)	10						TCCAGAAGACCCATGAGCGGA	0.542000													7	61					0	0	1	0	0
MTMR14	64419	broad.mit.edu	37	3	9695337	9695337	+	Silent	SNP	G	G	T			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr3:9695337G>T	ENST00000296003.4	+	2	314	c.192G>T	c.(190-192)ctG>ctT	p.L64L	MTMR14_ENST00000420925.1_Intron|MTMR14_ENST00000351233.5_Silent_p.L64L|MTMR14_ENST00000353332.5_Silent_p.L64L	NM_001077525.2	NP_001070993.1	Q8NCE2	MTMRE_HUMAN	myotubularin related protein 14	64						perinuclear region of cytoplasm|ruffle	phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity			breast(1)|endometrium(3)|kidney(2)|lung(10)|skin(3)|upper_aerodigestive_tract(2)	21	Medulloblastoma(99;0.227)					GTCTGGAGCTGTTTGGCCGAG	0.507000													29	103					8.88839e-20	1.04499e-19	1	1	0
KIAA0232	9778	broad.mit.edu	37	4	6878388	6878388	+	Splice_Site	SNP	A	A	T			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr4:6878388A>T	ENST00000307659.5	+	9	4367	c.3910_splice	c.e9-1	p.E1304_splice	KIAA0232_ENST00000425103.1_Splice_Site_p.E1304_splice	NM_014743.2	NP_055558.2	Q92628	K0232_HUMAN	KIAA0232	1304							ATP binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(12)|ovary(2)|prostate(4)|skin(1)|urinary_tract(1)	41						ATGATTAAGAATGTTACACAA	0.363000													5	46					0	0	1	0	0
PHF3	23469	broad.mit.edu	37	6	64394926	64394926	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr6:64394926A>G	ENST00000262043.3	+	4	1643	c.1303A>G	c.(1303-1305)Atc>Gtc	p.I435V	PHF3_ENST00000509330.1_Missense_Mutation_p.I435V|PHF3_ENST00000393387.1_Missense_Mutation_p.I435V			Q92576	PHF3_HUMAN	PHD finger protein 3	435					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			breast(7)|cervix(2)|endometrium(8)|kidney(7)|large_intestine(18)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(6)	75	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			GGAAAGTAATATCTTGGAAAA	0.368000													12	114					0	0	1	0	0
PCDHGC5	56097	broad.mit.edu	37	5	140871023	140871023	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr5:140871023C>T	ENST00000252087.1	+	1	2216	c.2216C>T	c.(2215-2217)cCg>cTg	p.P739L	PCDHGA6_ENST00000517434.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGC4_ENST00000306593.1_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGA12_ENST00000252085.3_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA11_ENST00000518882.1_Intron|PCDHGA11_ENST00000398587.2_Intron|PCDHGB7_ENST00000398594.2_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGC3_ENST00000308177.3_Intron	NM_018929.2|NM_032403.2|NM_032407.1	NP_061752.1|NP_115779.1|NP_115783.1	Q9Y5F6	PCDGM_HUMAN		739					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(2)|endometrium(6)|kidney(4)|large_intestine(4)|lung(10)|ovary(4)|prostate(1)|urinary_tract(2)	35			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCACCCTCCCCGGACTTCTAT	0.632000													7	80					0	0	1	0	0
MCOLN3	55283	broad.mit.edu	37	1	85506782	85506782	+	Silent	SNP	G	G	A			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr1:85506782G>A	ENST00000370587.1	-	4	683	c.307C>T	c.(307-309)Cta>Tta	p.L103L	WDR63_ENST00000370596.1_Intron|MCOLN3_ENST00000370589.2_Silent_p.L103L|MCOLN3_ENST00000341115.4_Intron			Q8TDD5	MCLN3_HUMAN	mucolipin 3	103						integral to membrane	ion channel activity			endometrium(6)|kidney(3)|large_intestine(9)|lung(12)|prostate(3)|skin(1)	34				all cancers(265;0.00957)|Epithelial(280;0.0254)		TATCCTTTTAGGAAAAGGTGT	0.368000													4	72					0	0	1	0	0
YIPF7	285525	broad.mit.edu	37	4	44638032	44638032	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr4:44638032C>T	ENST00000332990.5	-	3	275	c.259G>A	c.(259-261)Gca>Aca	p.A87T		NM_182592.2	NP_872398.2	Q8N8F6	YIPF7_HUMAN	Yip1 domain family, member 7	87						endoplasmic reticulum membrane|integral to membrane				breast(1)|large_intestine(1)|lung(9)|upper_aerodigestive_tract(1)	12						AATTGTCCTGCGTAACCCGAT	0.403000													7	35					0	0	1	0	0
TIAM1	7074	broad.mit.edu	37	21	32617877	32617877	+	Missense_Mutation	SNP	G	G	A	rs146528832		TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr21:32617877G>A	ENST00000286827.3	-	7	1982	c.1511C>T	c.(1510-1512)gCg>gTg	p.A504V	TIAM1_ENST00000541036.1_Missense_Mutation_p.A504V|TIAM1_ENST00000469412.1_5'UTR	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	504	PH 1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						CTCAGGCACCGCCTGCACAAT	0.552000													5	37					0	0	1	0	0
PCDHGB1	56104	broad.mit.edu	37	5	140731367	140731367	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr5:140731367C>T	ENST00000523390.1	+	1	1540	c.1540C>T	c.(1540-1542)Cgc>Tgc	p.R514C	PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018922.2|NM_032095.1	NP_061745.1|NP_115266.1														central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)	16			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTTCGCGCAGCGCGCCTTCGA	0.682000													11	88					0	0	1	0	0
ACOT12	134526	broad.mit.edu	37	5	80640726	80640726	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr5:80640726A>T	ENST00000307624.3	-	8	936	c.908T>A	c.(907-909)aTc>aAc	p.I303N		NM_130767.2	NP_570123.1	Q8WYK0	ACO12_HUMAN	acyl-CoA thioesterase 12	303					acyl-CoA metabolic process|fatty acid metabolic process	cytosol	acetyl-CoA hydrolase activity|carboxylesterase activity			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(7)|ovary(2)	23		Lung NSC(167;0.0176)|all_lung(232;0.0205)|Ovarian(174;0.135)		OV - Ovarian serous cystadenocarcinoma(54;1.37e-45)|Epithelial(54;1.25e-39)|all cancers(79;5.01e-34)		AATGGGTTGGATTCTGGGAAA	0.478000													6	61					0	0	1	0	0
ZNF367	195828	broad.mit.edu	37	9	99157147	99157147	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr9:99157147G>A	ENST00000375256.4	-	3	945	c.649C>T	c.(649-651)Cgt>Tgt	p.R217C		NM_153695.3	NP_710162.1	Q7RTV3	ZN367_HUMAN	zinc finger protein 367	217					regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			cervix(1)|endometrium(4)|large_intestine(3)|lung(3)|prostate(1)	12		Acute lymphoblastic leukemia(62;0.0167)				GTGTGAAGACGCTGATGTGTT	0.388000													16	39					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181701953	181701953	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr1:181701953C>T	ENST00000526775.1	+	19	2839	c.2674C>T	c.(2674-2676)Cgg>Tgg	p.R892W	CACNA1E_ENST00000367573.2_Missense_Mutation_p.R911W|CACNA1E_ENST00000358338.5_Missense_Mutation_p.R843W|CACNA1E_ENST00000357570.5_Missense_Mutation_p.R862W|CACNA1E_ENST00000367567.4_Missense_Mutation_p.R518W|CACNA1E_ENST00000367570.1_Missense_Mutation_p.R911W|CACNA1E_ENST00000360108.3_Missense_Mutation_p.R892W	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	911					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						CTTTGAGGACCGGGCCAGGCA	0.672000													11	106					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9091432	9091432	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr19:9091432G>T	ENST00000397910.4	-	1	586	c.383C>A	c.(382-384)tCc>tAc	p.S128Y		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	128	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGTCCTTGGGGAACTCAATCC	0.502000													9	86					0.335167	0.335167	1	1	0
CD40LG	959	broad.mit.edu	37	X	135741436	135741436	+	Missense_Mutation	SNP	A	A	C			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chrX:135741436A>C	ENST00000370629.2	+	5	704	c.648A>C	c.(646-648)aaA>aaC	p.K216N	CD40LG_ENST00000370628.2_Missense_Mutation_p.K195N	NM_000074.2	NP_000065.1	P29965	CD40L_HUMAN	CD40 ligand	216					anti-apoptosis|B cell proliferation|inflammatory response|isotype switching|leukocyte cell-cell adhesion|platelet activation|positive regulation of endothelial cell apoptosis|positive regulation of interleukin-12 production	extracellular space|integral to plasma membrane|soluble fraction	CD40 receptor binding|cytokine activity|tumor necrosis factor receptor binding			endometrium(1)|kidney(1)|large_intestine(8)|lung(14)|skin(1)|stomach(1)	26	Acute lymphoblastic leukemia(192;0.000127)				Atorvastatin(DB01076)	GTTCCGCCAAACCTTGCGGGC	0.493000									Immune Deficiency with Hyper-IgM				33	168					0	0	1	0	0
TMPRSS9	360200	broad.mit.edu	37	19	2422072	2422072	+	Missense_Mutation	SNP	C	C	T	rs138523679	byFrequency	TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr19:2422072C>T	ENST00000332578.3	+	13	2273	c.2273C>T	c.(2272-2274)aCg>aTg	p.T758M		NM_182973.1	NP_892018.1	Q7Z410	TMPS9_HUMAN	transmembrane protease, serine 9	758					proteolysis	integral to plasma membrane	serine-type endopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGCCCCAGGACGACAGCTGGC	0.657000													9	76					0	0	1	0	0
SNX10	29887	broad.mit.edu	37	7	26404670	26404670	+	Silent	SNP	A	A	G			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr7:26404670A>G	ENST00000338523.4	+	5	403	c.216A>G	c.(214-216)caA>caG	p.Q72Q	SNX10_ENST00000446848.2_Silent_p.Q98Q|SNX10_ENST00000396376.1_Silent_p.Q72Q|SNX10_ENST00000409838.1_5'UTR|SNX10_ENST00000409367.1_Silent_p.Q32Q	NM_001199835.1|NM_013322.2	NP_001186764.1|NP_037454.2	Q9Y5X0	SNX10_HUMAN	sorting nexin 10	72	PX.				cell communication|endosome organization|protein transport	extrinsic to endosome membrane	1-phosphatidylinositol binding			endometrium(1)|large_intestine(1)|lung(3)|upper_aerodigestive_tract(1)	6						TCCTAAGACAACTGCCAGAAC	0.393000											OREG0017908	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	49					0	0	1	0	0
ADAMTS7	11173	broad.mit.edu	37	15	79051886	79051886	+	Silent	SNP	G	G	A			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr15:79051886G>A	ENST00000388820.4	-	24	5148	c.4938C>T	c.(4936-4938)tgC>tgT	p.C1646C		NM_014272.3	NP_055087.2	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 7	1646	PLAC.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding	p.C1646C(4)		NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(23)|ovary(1)|prostate(8)|skin(9)	54						GCAGCGTCTCGCAGAACCCGA	0.701000													5	24					0	0	1	0	0
MYO1B	4430	broad.mit.edu	37	2	192250758	192250758	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr2:192250758A>G	ENST00000392318.3	+	16	1749	c.1502A>G	c.(1501-1503)aAt>aGt	p.N501S	MYO1B_ENST00000339514.4_Missense_Mutation_p.N501S|MYO1B_ENST00000304164.4_Missense_Mutation_p.N501S|MYO1B_ENST00000392316.1_Missense_Mutation_p.N501S	NM_001130158.1	NP_001123630.1	O43795	MYO1B_HUMAN	myosin IB	501	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|central_nervous_system(6)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(19)|ovary(1)	55			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.104)|all cancers(119;0.236)			CGGTTCCTCAATGACACGTCT	0.532000													22	254					0	0	1	0	0
MMAB	326625	broad.mit.edu	37	12	109998858	109998858	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr12:109998858G>A	ENST00000545712.2	-	7	964	c.571C>T	c.(571-573)Cgg>Tgg	p.R191W	MMAB_ENST00000266839.5_Missense_Mutation_p.R100W|MMAB_ENST00000540016.1_Missense_Mutation_p.R139W	NM_052845.3	NP_443077.1	Q96EY8	MMAB_HUMAN	methylmalonic aciduria (cobalamin deficiency) cblB type	191			R -> W (in MMAB).		cobalamin biosynthetic process	mitochondrion	ATP binding|cob(I)yrinic acid a,c-diamide adenosyltransferase activity			cervix(1)|kidney(1)|large_intestine(2)|lung(1)|urinary_tract(1)	6					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CTCTCGGCCCGGCGGCACACG	0.657000													8	48					0	0	1	0	0
ATAD5	79915	broad.mit.edu	37	17	29219776	29219776	+	Silent	SNP	C	C	T			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr17:29219776C>T	ENST00000321990.4	+	20	4788	c.4410C>T	c.(4408-4410)tcC>tcT	p.S1470S		NM_024857.3	NP_079133.3	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	1470					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(3)|large_intestine(18)|lung(13)|ovary(3)|pancreas(1)	51		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				ACATTTTTTCCCCATCTGAAG	0.328000													5	121					0	0	1	0	0
OR4K5	79317	broad.mit.edu	37	14	20389008	20389008	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr14:20389008G>T	ENST00000315915.4	+	1	268	c.243G>T	c.(241-243)atG>atT	p.M81I		NM_001005483.1	NP_001005483.1	Q8NGD3	OR4K5_HUMAN	olfactory receptor, family 4, subfamily K, member 5	81					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.M81I(1)		central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|liver(1)|lung(27)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	47	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CCCCTAAAATGATTGCAGATT	0.438000													16	200					1.15088e-07	1.30034e-07	1	1	0
CDKN2A	1029	broad.mit.edu	37	9	21968242	21968242	+	Splice_Site	SNP	C	C	T			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr9:21968242C>T	ENST00000579755.1	-	3	793		c.e3-1		CDKN2A_ENST00000498628.2_Splice_Site|RP11-145E5.5_ENST00000404796.2_Intron|CDKN2A_ENST00000579122.1_Splice_Site|CDKN2A_ENST00000494262.1_Splice_Site|CDKN2A_ENST00000361570.3_Splice_Site|CDKN2A_ENST00000530628.2_Splice_Site|CDKN2A_ENST00000304494.5_Splice_Site|CDKN2A_ENST00000498124.1_Splice_Site|CDKN2A_ENST00000578845.2_Splice_Site			P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A						cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein kinase binding	p.0?(1315)|p.?(6)|p.0(1)		NS(28)|adrenal_gland(6)|autonomic_ganglia(11)|biliary_tract(74)|bone(84)|breast(46)|central_nervous_system(522)|cervix(23)|endometrium(14)|eye(4)|genital_tract(15)|haematopoietic_and_lymphoid_tissue(698)|kidney(39)|large_intestine(11)|liver(92)|lung(365)|meninges(18)|oesophagus(239)|ovary(98)|pancreas(263)|pleura(94)|prostate(13)|salivary_gland(10)|skin(541)|small_intestine(1)|soft_tissue(93)|stomach(48)|thymus(4)|thyroid(24)|upper_aerodigestive_tract(436)|urinary_tract(283)|vulva(2)	4199		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TCGGGGATGTCTGCAGAGGGC	0.542000		17								HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			7	38					0	0	1	0	0
ZNF730	100129543	broad.mit.edu	37	19	23329013	23329013	+	Silent	SNP	T	T	A			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr19:23329013T>A	ENST00000597761.2	+	4	1366	c.1167T>A	c.(1165-1167)atT>atA	p.I389I		NM_001277403.1	NP_001264332.1			zinc finger protein 730											endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(7)|pancreas(1)|stomach(2)|urinary_tract(1)	16						ATAAGATAATTCATACTGTAG	0.338000													5	16					0	0	1	0	0
GRXCR2	643226	broad.mit.edu	37	5	145252448	145252448	+	Silent	SNP	G	G	A	rs141618183	byFrequency	TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr5:145252448G>A	ENST00000377976.1	-	1	83	c.84C>T	c.(82-84)agC>agT	p.S28S		NM_001080516.1	NP_001073985.1	A6NFK2	GRCR2_HUMAN	glutaredoxin, cysteine rich 2	28										breast(1)|endometrium(1)|large_intestine(2)|lung(1)|urinary_tract(2)	7						ATACTCGACCGCTGTAGGAGG	0.468000													12	150					0	0	1	0	0
PGM5	5239	broad.mit.edu	37	9	71098912	71098912	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr9:71098912C>T	ENST00000396396.1	+	9	1656	c.1427C>T	c.(1426-1428)aCg>aTg	p.T476M		NM_021965.3	NP_068800.2	Q15124	PGM5_HUMAN	phosphoglucomutase 5	476					cell adhesion|cellular calcium ion homeostasis|glucose metabolic process	costamere|dystrophin-associated glycoprotein complex|focal adhesion|intercalated disc|internal side of plasma membrane|sarcolemma|spot adherens junction|stress fiber|Z disc	intramolecular transferase activity, phosphotransferases|magnesium ion binding|structural molecule activity			endometrium(5)|kidney(1)|large_intestine(5)|liver(2)|lung(15)|ovary(1)|pancreas(1)|prostate(3)|skin(1)	34						GTGGCGAAGACGGATAGTTTT	0.502000													12	111					0	0	1	0	0
KIF1B	23095	broad.mit.edu	37	1	10435384	10435384	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr1:10435384G>T	ENST00000377086.1	+	48	5563	c.5361G>T	c.(5359-5361)atG>atT	p.M1787I	KIF1B_ENST00000377081.1_Missense_Mutation_p.M1787I|KIF1B_ENST00000263934.6_Missense_Mutation_p.M1741I			O60333	KIF1B_HUMAN	kinesin family member 1B	1787	PH.				anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			breast(2)|endometrium(7)|kidney(8)|large_intestine(9)|lung(29)|ovary(3)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(2)	71	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		ACAAAGACATGAACGACTGGT	0.438000													8	99					2.17888e-05	2.34028e-05	1	1	0
BDKRB2	624	broad.mit.edu	37	14	96706870	96706870	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr14:96706870G>A	ENST00000542454.2	+	3	3212	c.124G>A	c.(124-126)Gtg>Atg	p.V42M	BDKRB2_ENST00000539359.1_Missense_Mutation_p.V42M|BDKRB2_ENST00000554311.1_Missense_Mutation_p.V69M|RP11-404P21.8_ENST00000553811.1_Intron|BDKRB2_ENST00000306005.3_Missense_Mutation_p.V69M			P30411	BKRB2_HUMAN	bradykinin receptor B2	69					arachidonic acid secretion|elevation of cytosolic calcium ion concentration|transmembrane receptor protein tyrosine kinase signaling pathway	endosome|integral to plasma membrane	bradykinin receptor activity|phosphatidylinositol phospholipase C activity|protease binding|protein heterodimerization activity|type 1 angiotensin receptor binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(5)|lung(7)|ovary(3)|skin(1)	24		all_cancers(154;0.0678)|Melanoma(154;0.155)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.226)		GGTGCTGTTCGTGCTGGCCAC	0.612000													23	140					0	0	1	0	0
LRRC43	254050	broad.mit.edu	37	12	122677440	122677440	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr12:122677440A>T	ENST00000339777.4	+	7	1266	c.1238A>T	c.(1237-1239)gAg>gTg	p.E413V	LRRC43_ENST00000425921.1_Missense_Mutation_p.E228V	NM_152759.4	NP_689972.3	Q8N309	LRC43_HUMAN	leucine rich repeat containing 43	413	Glu-rich.									NS(1)|endometrium(1)|large_intestine(4)|lung(10)|skin(1)|upper_aerodigestive_tract(2)	19	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000312)|Epithelial(86;0.000539)|BRCA - Breast invasive adenocarcinoma(302;0.225)		GGAGAGTCGGAGCTGTCTGTC	0.567000													9	48					0	0	1	0	0
FZD1	8321	broad.mit.edu	37	7	90895444	90895444	+	Missense_Mutation	SNP	T	T	G			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr7:90895444T>G	ENST00000287934.2	+	1	1662	c.1249T>G	c.(1249-1251)Tcc>Gcc	p.S417A		NM_003505.1	NP_003496.1	Q9UP38	FZD1_HUMAN	frizzled family receptor 1	417					autocrine signaling|axonogenesis|brain development|canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|embryo development|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|lung alveolus development|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to drug|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cell surface|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|receptor binding|Wnt receptor activity|Wnt-protein binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(4)|liver(1)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24	all_cancers(62;3.1e-10)|all_epithelial(64;1.66e-08)|Breast(17;0.000635)|Lung NSC(181;0.153)|all_lung(186;0.154)|all_hematologic(106;0.215)		STAD - Stomach adenocarcinoma(171;0.0134)			CATGGCCAGCTCCATCTGGTG	0.602000													8	63					0	0	1	0	0
KIAA0556	23247	broad.mit.edu	37	16	27777718	27777718	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr16:27777718C>T	ENST00000261588.4	+	20	3917	c.3898C>T	c.(3898-3900)Cgc>Tgc	p.R1300C		NM_015202.2	NP_056017.2	O60303	K0556_HUMAN	KIAA0556	1300										breast(4)|endometrium(7)|kidney(8)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	76						GGTCACGATCCGCCTGGACAG	0.582000													11	78					0	0	1	0	0
GRK7	131890	broad.mit.edu	37	3	141535597	141535597	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr3:141535597C>T	ENST00000264952.2	+	4	1504	c.1367C>T	c.(1366-1368)aCg>aTg	p.T456M		NM_139209.2	NP_631948.1	Q8WTQ7	GRK7_HUMAN	G protein-coupled receptor kinase 7	456	AGC-kinase C-terminal.				visual perception	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(14)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	26						TTCTTTAAAACGATCAACTTT	0.423000													12	136					0	0	1	0	0
ABL1	25	broad.mit.edu	37	9	133755972	133755972	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr9:133755972G>T	ENST00000318560.5	+	10	1980	c.1599G>T	c.(1597-1599)agG>agT	p.R533S		NM_005157.4	NP_005148.2	P00519	ABL1_HUMAN	c-abl oncogene 1, non-receptor tyrosine kinase	533					actin cytoskeleton organization|axon guidance|blood coagulation|cell adhesion|DNA damage induced protein phosphorylation|DNA damage response, signal transduction resulting in induction of apoptosis|mismatch repair|muscle cell differentiation|negative regulation of protein serine/threonine kinase activity|peptidyl-tyrosine phosphorylation|positive regulation of muscle cell differentiation|positive regulation of oxidoreductase activity|regulation of transcription involved in S phase of mitotic cell cycle	cytoskeleton|cytosol|nuclear membrane|nucleolus|perinuclear region of cytoplasm	ATP binding|DNA binding|magnesium ion binding|manganese ion binding|mitogen-activated protein kinase binding|non-membrane spanning protein tyrosine kinase activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding			breast(3)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1149)|kidney(3)|large_intestine(7)|lung(15)|ovary(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	1195		all_hematologic(13;0.0361)|Acute lymphoblastic leukemia(5;0.0543)|Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.4e-05)	Adenosine triphosphate(DB00171)|Dasatinib(DB01254)|Imatinib(DB00619)	CCAAGACGAGGACCTCCAGGA	0.602000			"""T, Mis"""	"""BCR, ETV6, NUP214"""	"""CML, ALL, T-ALL"""								13	39					9.05144e-12	1.04997e-11	1	1	0
HAUS6	54801	broad.mit.edu	37	9	19102605	19102605	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr9:19102605C>A	ENST00000380502.3	-	1	512	c.45G>T	c.(43-45)tgG>tgT	p.W15C		NM_017645.3	NP_060115.3	Q7Z4H7	HAUS6_HUMAN	HAUS augmin-like complex, subunit 6	15					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|nucleus|spindle				autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						GCAGATACATCCAGAGATGCT	0.637000													6	42					0.0293803	0.029722	1	1	0
GRIN2A	2903	broad.mit.edu	37	16	10032120	10032120	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr16:10032120C>T	ENST00000396573.2	-	4	1012	c.703G>A	c.(703-705)Gag>Aag	p.E235K	GRIN2A_ENST00000566670.1_5'UTR|GRIN2A_ENST00000562109.1_Missense_Mutation_p.E235K|GRIN2A_ENST00000535259.1_Missense_Mutation_p.E78K|GRIN2A_ENST00000404927.2_Missense_Mutation_p.E235K|GRIN2A_ENST00000396575.2_Missense_Mutation_p.E235K|GRIN2A_ENST00000330684.3_Missense_Mutation_p.E235K	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	235					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	AGAACAGCCTCGTCTTTGGAA	0.507000													7	61					0	0	1	0	0
MYO9A	4649	broad.mit.edu	37	15	72142383	72142383	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr15:72142383G>C	ENST00000356056.5	-	38	7179	c.6707C>G	c.(6706-6708)aCt>aGt	p.T2236S	MYO9A_ENST00000424560.1_Missense_Mutation_p.T2307S|MYO9A_ENST00000564571.1_Missense_Mutation_p.T2236S|MYO9A_ENST00000444904.1_Missense_Mutation_p.T2217S	NM_006901.3	NP_008832.2	B2RTY4	MYO9A_HUMAN	myosin IXA	2236	Rho-GAP.|Tail.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(29)|lung(27)|ovary(1)|pancreas(1)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						TTACGTGGTAGTCTTACTGAT	0.468000													5	69					0	0	1	0	0
MYLK	4638	broad.mit.edu	37	3	123451756	123451756	+	Silent	SNP	G	G	T			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr3:123451756G>T	ENST00000360772.3	-	12	1881	c.1503C>A	c.(1501-1503)acC>acA	p.T501T	MYLK_ENST00000475616.1_Silent_p.T501T|MYLK_ENST00000360304.3_Silent_p.T501T|MYLK_ENST00000359169.1_Silent_p.T501T|MYLK_ENST00000346322.5_Intron			Q15746	MYLK_HUMAN	myosin light chain kinase	501	Ig-like C2-type 3.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		CCACTTGGAGGGTCCAGCTAC	0.567000													17	44					0.000958276	0.00101671	1	1	0
FOXC1	2296	broad.mit.edu	37	6	1611463	1611465	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr6:1611463_1611465delCAG	ENST00000380874.2	+	1	783_785	c.783_785delCAG	c.(781-786)gac>ga	p.DS261del		NM_001453.2	NP_001444.2	Q12948	FOXC1_HUMAN	forkhead box C1	261					anti-apoptosis|artery morphogenesis|blood vessel remodeling|brain development|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|germ cell migration|glycosaminoglycan metabolic process|lacrimal gland development|lymphangiogenesis|metanephros development|negative regulation of mitotic cell cycle|neural crest cell fate commitment|Notch signaling pathway|odontogenesis of dentine-containing tooth|ossification|ovarian follicle development|paraxial mesodermal cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|regulation of blood vessel size|regulation of organ growth|regulation of sequence-specific DNA binding transcription factor activity|somitogenesis|ureteric bud development|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	nuclear heterochromatin|transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(1)	8	Ovarian(93;0.0733)	all_cancers(2;4.45e-07)|all_epithelial(2;4.33e-05)|all_lung(73;0.0713)|all_hematologic(90;0.0895)		Epithelial(2;0.0904)|OV - Ovarian serous cystadenocarcinoma(45;0.095)|all cancers(2;0.168)		AGAGCCCCGACAGCAGCAGCAGC	0.793													2	4	---	---	---	---					
TMEM120A	83862	broad.mit.edu	37	7	75616818	75616821	+	RNA	DEL	GACA	GACA	-	rs71741566		TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr7:75616818_75616821delGACA	ENST00000493111.2	-	0	849				TMEM120A_ENST00000338761.4_RNA			Q9BXJ8	T120A_HUMAN	transmembrane protein 120A							integral to membrane											GCAGAGGACGGACAGACAGACAGG	0.574													6	6	---	---	---	---					
MMP12	4321	broad.mit.edu	37	11	102738793	102738794	+	RNA	INS	-	-	T	rs35342965	by1000genomes	TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr11:102738793_102738794insT	ENST00000532855.1	-	0	727_728							P39900	MMP12_HUMAN	matrix metallopeptidase 12 (macrophage elastase)						positive regulation of epithelial cell proliferation involved in wound healing|proteolysis|wound healing, spreading of epidermal cells	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	26		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.014)	Acetohydroxamic Acid(DB00551)	TGAGGAACAAGTGGTGCCTAAG	0.416													3	6	---	---	---	---					
RP11-252A24.2	0	broad.mit.edu	37	16	74394379	74394380	+	RNA	INS	-	-	A	rs142790741	by1000genomes	TCGA-BA-A6DD-01A-12D-A31L-08	TCGA-BA-A6DD-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cee6020-356f-4c2e-85f1-63a1c0e8a8d2	b532630e-1958-4c87-b70b-a5ace90aa753	g.chr16:74394379_74394380insA	ENST00000429810.2	-	0	435																											TAGTCATCCTTAAACAAAATTC	0.347													4	2	---	---	---	---