Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
PRAMEF11	440560	broad.mit.edu	37	1	12887574	12887574	+	Missense_Mutation	SNP	C	C	G			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr1:12887574C>G	uc001auk.2	-	3	479	c.283G>C	c.(283-285)GTG>CTG	p.V95L		NM_001146344	NP_001139816	O60813	PRA11_HUMAN	PRAME family member 11	95											0						CAGTCCTGCACTGGTGTTTTG	0.498		NA											11	236					0	0	0	0
TTF2	8458	broad.mit.edu	37	1	117624536	117624536	+	Nonsense_Mutation	SNP	A	A	T			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr1:117624536A>T	uc001egy.2	+	10	1890	c.1870A>T	c.(1870-1872)AAA>TAA	p.K624*	TTF2_uc001egx.1_Nonsense_Mutation_p.K624*	NM_003594	NP_003585	Q9UNY4	TTF2_HUMAN	transcription termination factor, RNA polymerase	624	Helicase ATP-binding.				mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|termination of RNA polymerase II transcription	cytoplasm|spliceosomal complex|transcription elongation factor complex	ATP binding|ATP-dependent helicase activity|DNA binding|DNA-dependent ATPase activity|protein binding|zinc ion binding			ovary(1)	1	Lung SC(450;0.225)	all_cancers(81;4.23e-06)|all_epithelial(167;3.65e-07)|all_lung(203;2.81e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0553)|Colorectal(144;0.179)|LUSC - Lung squamous cell carcinoma(189;0.19)		AGAAAAGGAGAAAAGCACAGC	0.453		NA											5	53					0	0	0	0
FLG	2312	broad.mit.edu	37	1	152280551	152280551	+	Missense_Mutation	SNP	C	C	A			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr1:152280551C>A	uc001ezu.1	-	3	6847	c.6811G>T	c.(6811-6813)GCT>TCT	p.A2271S		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2271	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGCTCCTGAGCAGATCCATGA	0.582		NA							Ichthyosis				25	264					5.45e-15	7.68e-15	1	0
C1orf114	57821	broad.mit.edu	37	1	169390949	169390949	+	Silent	SNP	A	A	C			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr1:169390949A>C	uc001gga.1	-	3	888	c.720T>G	c.(718-720)CCT>CCG	p.P240P	C1orf114_uc001gfz.1_Silent_p.P240P|C1orf114_uc009wvq.1_Silent_p.P240P|C1orf114_uc001ggb.2_Silent_p.P240P|C1orf114_uc001ggc.1_Silent_p.P240P	NM_021179	NP_067002	Q5TID7	CA114_HUMAN	hypothetical protein LOC57821	240											0	all_hematologic(923;0.208)					TATTAATGGGAGGCAAAAACC	0.408		NA											17	109					0	0	0	0
SRGAP2	23380	broad.mit.edu	37	1	206628236	206628236	+	Silent	SNP	C	C	T			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr1:206628236C>T	uc001hdy.2	+	18	2445	c.2112C>T	c.(2110-2112)GTC>GTT	p.V704V	SRGAP2_uc001hdx.2_Silent_p.V704V|SRGAP2_uc010pru.1_Silent_p.V627V	NM_015326	NP_056141	O75044	FNBP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 2	791					axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding				0	Breast(84;0.137)					AGGACGGTGTCGTGGAGAGGT	0.597		NA											4	34					0	0	0	0
C10orf107	219621	broad.mit.edu	37	10	63450358	63450358	+	Silent	SNP	A	A	G			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr10:63450358A>G	uc010qik.1	+	4	572	c.267A>G	c.(265-267)GAA>GAG	p.E89E		NM_173554	NP_775825	Q8IVU9	CJ107_HUMAN	hypothetical protein LOC219621	89											0	Prostate(12;0.016)					CTGCCAGGGAAGAAATTGTGA	0.343		NA											7	46					0	0	0	0
SYT9	143425	broad.mit.edu	37	11	7439283	7439283	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr11:7439283G>A	uc001mfe.2	+	5	1498	c.1261G>A	c.(1261-1263)GAA>AAA	p.E421K	SYT9_uc001mfd.2_RNA|SYT9_uc009yfi.2_RNA	NM_175733	NP_783860	Q86SS6	SYT9_HUMAN	synaptotagmin IX	421	Cytoplasmic (Potential).|C2 2.					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(2)|large_intestine(1)	3				Epithelial(150;1.34e-07)|LUSC - Lung squamous cell carcinoma(625;0.0949)		TGTTTACAACGAAGCCATAGT	0.468		NA											6	61					0	0	0	0
OR4C16	219428	broad.mit.edu	37	11	55339695	55339695	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr11:55339695G>A	uc010rih.1	+	1	92	c.92G>A	c.(91-93)CGT>CAT	p.R31H		NM_001004701	NP_001004701	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C,	31	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		all_epithelial(135;0.0748)				ATTTTTTTGCGTCTCTACTTG	0.368		NA											7	89					0	0	0	0
WDR74	54663	broad.mit.edu	37	11	62606655	62606655	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr11:62606655C>T	uc001nvm.1	-	4	392	c.224G>A	c.(223-225)GGC>GAC	p.G75D	WDR74_uc001nvk.1_Missense_Mutation_p.G18D|WDR74_uc001nvl.1_Missense_Mutation_p.G75D|WDR74_uc001nvn.1_Missense_Mutation_p.G127D|WDR74_uc009yoi.1_Missense_Mutation_p.G75D|WDR74_uc010rmk.1_Missense_Mutation_p.G75D	NM_018093	NP_060563	Q6RFH5	WDR74_HUMAN	WD repeat domain 74	75	WD 1.					nucleolus				ovary(1)	1						CTGGAATATGCCATCCTCGGT	0.652		NA											4	46					0	0	0	0
SESN3	143686	broad.mit.edu	37	11	94911920	94911920	+	Missense_Mutation	SNP	T	T	G			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr11:94911920T>G	uc001pfk.1	-	7	1232	c.1010A>C	c.(1009-1011)GAC>GCC	p.D337A	SESN3_uc010rug.1_Missense_Mutation_p.D198A	NM_144665	NP_653266	P58005	SESN3_HUMAN	sestrin 3	337					cell cycle arrest	nucleus					0		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)		BRCA - Breast invasive adenocarcinoma(274;0.234)		TCTGGCAAAGTCTTCATACCC	0.363		NA											7	46					0	0	0	0
ST8SIA1	6489	broad.mit.edu	37	12	22408274	22408274	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr12:22408274C>T	uc001rfo.3	-	3	913	c.431G>A	c.(430-432)GGT>GAT	p.G144D	ST8SIA1_uc009zix.2_Intron	NM_003034	NP_003025	Q92185	SIA8A_HUMAN	alpha-2,8-sialyltransferase 1	144	Lumenal (Potential).				glycosphingolipid biosynthetic process|protein glycosylation	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			ovary(3)	3						CAGAATCCCACCATTTCCCAC	0.517		NA											10	100					0	0	0	0
MLL2	8085	broad.mit.edu	37	12	49445626	49445626	+	Nonsense_Mutation	SNP	C	C	A			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr12:49445626C>A	uc001rta.3	-	10	1840	c.1840G>T	c.(1840-1842)GAG>TAG	p.E614*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	614	15 X 5 AA repeats of S/P-P-P-E/P-E/A.|Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						AGGGGAGACTCCTCAGGTGGA	0.602		NA	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			9	49					2.18e-05	3.01e-05	1	0
KIF5A	3798	broad.mit.edu	37	12	57958726	57958726	+	Silent	SNP	C	C	T	rs143178113		TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr12:57958726C>T	uc001sor.1	+	6	679	c.471C>T	c.(469-471)CAC>CAT	p.H157H	KIF5A_uc010srr.1_Silent_p.H68H	NM_004984	NP_004975	Q12840	KIF5A_HUMAN	kinesin family member 5A	157	Kinesin-motor.				blood coagulation|cell death|microtubule-based movement|synaptic transmission	cytosol|kinesin complex|membrane fraction|microtubule|perinuclear region of cytoplasm	ATP binding|microtubule motor activity			ovary(2)|skin(1)	3						TGTCCGTGCACGAGGACAAGA	0.532		NA											6	33					0	0	0	0
THAP2	83591	broad.mit.edu	37	12	72070612	72070612	+	Silent	SNP	G	G	A			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr12:72070612G>A	uc001swq.2	+	3	917	c.411G>A	c.(409-411)AGG>AGA	p.R137R		NM_031435	NP_113623	Q9H0W7	THAP2_HUMAN	THAP domain containing, apoptosis associated	137						nucleolus	DNA binding|metal ion binding			ovary(1)	1						CAAAAAAGAGGATCATTAAAC	0.383		NA											6	65					0	0	0	0
SACS	26278	broad.mit.edu	37	13	23914846	23914846	+	Missense_Mutation	SNP	C	C	G			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr13:23914846C>G	uc001uon.2	-	10	3758	c.3169G>C	c.(3169-3171)GAT>CAT	p.D1057H	SACS_uc001uoo.2_Missense_Mutation_p.D910H|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	1057					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		ACTTCTATATCAGGGTCAAAG	0.373		NA											5	115					0	0	0	0
SMOC1	64093	broad.mit.edu	37	14	70444647	70444647	+	Missense_Mutation	SNP	A	A	G			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr14:70444647A>G	uc001xls.1	+	5	744	c.491A>G	c.(490-492)GAC>GGC	p.D164G	SMOC1_uc001xlt.1_Missense_Mutation_p.D164G	NM_022137	NP_071420	Q9H4F8	SMOC1_HUMAN	secreted modular calcium-binding protein 1	164					cell differentiation|eye development|limb development|regulation of osteoblast differentiation|signal transduction	basement membrane	calcium ion binding			upper_aerodigestive_tract(1)|pancreas(1)	2				all cancers(60;0.00417)|BRCA - Breast invasive adenocarcinoma(234;0.0119)|OV - Ovarian serous cystadenocarcinoma(108;0.028)		TCAGTCACCGACAAGCCCTTG	0.433		NA											6	56					0	0	0	0
EFTUD1	79631	broad.mit.edu	37	15	82444535	82444535	+	Nonsense_Mutation	SNP	G	G	A			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr15:82444535G>A	uc002bgt.1	-	18	2429	c.2260C>T	c.(2260-2262)CGA>TGA	p.R754*	EFTUD1_uc002bgs.1_Nonsense_Mutation_p.R125*|EFTUD1_uc002bgu.1_Nonsense_Mutation_p.R703*	NM_024580	NP_078856	Q7Z2Z2	ETUD1_HUMAN	elongation factor Tu GTP binding domain	754					mature ribosome assembly		GTP binding|GTPase activity|ribosome binding|translation elongation factor activity			ovary(1)	1						GGCATGGCTCGAACACTGAGC	0.438		NA											7	75					0	0	0	0
SLC28A1	9154	broad.mit.edu	37	15	85447424	85447424	+	Silent	SNP	C	C	T			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr15:85447424C>T	uc002blg.2	+	7	760	c.558C>T	c.(556-558)TGC>TGT	p.C186C	SLC28A1_uc010upd.1_Silent_p.C108C|SLC28A1_uc010bnb.2_Silent_p.C186C|SLC28A1_uc010upe.1_Silent_p.C186C|SLC28A1_uc010upf.1_Silent_p.C186C|SLC28A1_uc010upg.1_Silent_p.C186C	NM_004213	NP_004204	O00337	S28A1_HUMAN	solute carrier family 28, member 1 isoform 1	186	Helical; (Potential).				nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding			skin(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(143;0.0587)			CAGGAATCTGCGTGTTCGTCG	0.597		NA											5	87					0	0	0	0
PLK1	5347	broad.mit.edu	37	16	23695252	23695252	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr16:23695252G>A	uc002dlz.1	+	5	931	c.878G>A	c.(877-879)CGC>CAC	p.R293H		NM_005030	NP_005021	P53350	PLK1_HUMAN	polo-like kinase 1	293	Protein kinase.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|G2/M transition DNA damage checkpoint|G2/M transition of mitotic cell cycle|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic prophase|negative regulation of cyclin-dependent protein kinase activity|peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein destabilization|protein localization to chromatin|protein ubiquitination|regulation of mitotic anaphase|regulation of protein binding	centrosome|condensed nuclear chromosome outer kinetochore|cytosol|nucleoplasm|spindle microtubule|spindle midzone|spindle pole	anaphase-promoting complex binding|ATP binding|polo kinase kinase activity|protein kinase binding			lung(1)|skin(1)	2				GBM - Glioblastoma multiforme(48;0.0156)		CCCACTGCCCGCCCAACCATT	0.547		NA											12	250					0	0	0	0
CNOT1	23019	broad.mit.edu	37	16	58583721	58583721	+	Missense_Mutation	SNP	C	C	G			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr16:58583721C>G	uc002env.2	-	25	3717	c.3424G>C	c.(3424-3426)GAG>CAG	p.E1142Q	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Missense_Mutation_p.E1137Q|CNOT1_uc002enx.2_Missense_Mutation_p.E1142Q|CNOT1_uc002enz.1_Missense_Mutation_p.E571Q|CNOT1_uc010vik.1_Missense_Mutation_p.E138Q|SNORA46_uc002eny.1_5'Flank	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	1142					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		AAGTTTGGCTCAATACTGACT	0.393		NA											6	87					0	0	0	0
ZFHX3	463	broad.mit.edu	37	16	72828433	72828433	+	Silent	SNP	G	G	A			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr16:72828433G>A	uc002fck.2	-	9	8821	c.8148C>T	c.(8146-8148)TGC>TGT	p.C2716C	ZFHX3_uc002fcl.2_Silent_p.C1802C	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	2716	C2H2-type 20.				muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				AGAGCGCTCTGCAAAAAGGGC	0.562		NA											17	65					0	0	0	0
SC65	10609	broad.mit.edu	37	17	39967445	39967445	+	Missense_Mutation	SNP	T	T	C			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr17:39967445T>C	uc002hxt.2	-	2	838	c.554A>G	c.(553-555)TAT>TGT	p.Y185C	FKBP10_uc002hxv.2_5'Flank|SC65_uc002hxu.2_Missense_Mutation_p.Y276C	NM_006455	NP_006446	Q92791	SC65_HUMAN	synaptonemal complex protein SC65	185					synaptonemal complex assembly	nucleolus|synaptonemal complex	binding				0		Breast(137;0.000162)		BRCA - Breast invasive adenocarcinoma(366;0.149)		CATCCCCTGATAGTAGTTGAG	0.647		NA											27	233					0	0	0	0
C18orf1	753	broad.mit.edu	37	18	13645527	13645527	+	Silent	SNP	C	C	T			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr18:13645527C>T	uc002ksa.2	+	7	1460	c.792C>T	c.(790-792)GGC>GGT	p.G264G	C18orf1_uc002ksb.2_Silent_p.G246G|C18orf1_uc002kse.2_Silent_p.G227G|C18orf1_uc002ksf.2_Silent_p.G209G|C18orf1_uc002ksg.1_Silent_p.G187G|C18orf1_uc002ksh.1_Silent_p.G206G|C18orf1_uc002ksi.1_Silent_p.G188G	NM_181481	NP_852146	O15165	CR001_HUMAN	hypothetical protein LOC753 isoform alpha 1	264	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(2)|skin(1)	3				READ - Rectum adenocarcinoma(73;0.0642)		ACCACCCAGGCGCCTCTTTCC	0.597		NA											9	60					0	0	0	0
TCEB3B	51224	broad.mit.edu	37	18	44559510	44559510	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr18:44559510C>T	uc002lcr.1	-	1	2479	c.2126G>A	c.(2125-2127)CGG>CAG	p.R709Q	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_016427	NP_057511	Q8IYF1	ELOA2_HUMAN	elongin A2	709					regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			ovary(2)|large_intestine(1)|pancreas(1)	4						GGGGTTGGCCCGCTTCTCAGG	0.547		NA											5	62					0	0	0	0
LPHN1	22859	broad.mit.edu	37	19	14268749	14268749	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr19:14268749G>A	uc010xnn.1	-	14	2791	c.2495C>T	c.(2494-2496)ACG>ATG	p.T832M	LPHN1_uc010xno.1_Missense_Mutation_p.T827M|uc002myf.2_Intron	NM_001008701	NP_001008701	O94910	LPHN1_HUMAN	latrophilin 1 isoform 1 precursor	832	GPS.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			ovary(2)|lung(2)|central_nervous_system(1)	5						GCAGGCACACGTGGTATGGGT	0.597		NA											5	61					0	0	0	0
ZNF540	163255	broad.mit.edu	37	19	38102814	38102814	+	Silent	SNP	T	T	C			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr19:38102814T>C	uc002ogq.2	+	5	965	c.633T>C	c.(631-633)GGT>GGC	p.G211G	ZNF540_uc002ogu.2_Silent_p.G211G|ZNF540_uc010efq.2_Silent_p.G179G	NM_152606	NP_689819	Q8NDQ6	ZN540_HUMAN	zinc finger protein 540	211					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)	1			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TTCATACTGGTGAAAAATCCT	0.338		NA											3	50					0	0	0	0
ANKRD36	375248	broad.mit.edu	37	2	97867947	97867947	+	Missense_Mutation	SNP	C	C	G	rs10203570	by1000genomes	TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr2:97867947C>G	uc010yva.1	+	47	3110	c.2866C>G	c.(2866-2868)CAG>GAG	p.Q956E	ANKRD36_uc002sxp.3_RNA	NM_001164315	NP_001157787	A6QL64	AN36A_HUMAN	ankyrin repeat domain 36	956											0						AGTGTCTTCTCAGAAACCACC	0.343		NA											2	13					0	0	0	0
KIF3B	9371	broad.mit.edu	37	20	30897727	30897727	+	Silent	SNP	G	G	A			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr20:30897727G>A	uc002wxq.2	+	2	314	c.147G>A	c.(145-147)ACG>ACA	p.T49T	KIF3B_uc010ztv.1_Silent_p.T49T|KIF3B_uc010ztw.1_Silent_p.T49T	NM_004798	NP_004789	O15066	KIF3B_HUMAN	kinesin family member 3B	49	Kinesin-motor.				anterograde axon cargo transport|blood coagulation|determination of left/right symmetry|mitotic centrosome separation|plus-end-directed vesicle transport along microtubule|spindle assembly involved in mitosis	centrosome|cytosol|kinesin II complex|plus-end kinesin complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|Rho GTPase binding			central_nervous_system(3)|ovary(2)	5			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			CCAAAGGGACGGCCCATGAAA	0.512		NA											5	52					0	0	0	0
BPIL3	128859	broad.mit.edu	37	20	31622901	31622901	+	Missense_Mutation	SNP	T	T	C			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr20:31622901T>C	uc010zuc.1	+	5	467	c.467T>C	c.(466-468)ATG>ACG	p.M156T	BPIL3_uc010zud.1_Missense_Mutation_p.M95T	NM_174897	NP_777557	Q8NFQ5	BPIL3_HUMAN	bactericidal/permeability-increasing	156						extracellular region	lipid binding			ovary(1)|pancreas(1)	2						CTCCCCAAGATGGTCAACAAG	0.577		NA											11	52					0	0	0	0
TOMM34	10953	broad.mit.edu	37	20	43585027	43585027	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr20:43585027G>A	uc002xmy.2	-	2	367	c.227C>T	c.(226-228)TCA>TTA	p.S76L	PABPC1L_uc002xmx.2_Intron|TOMM34_uc002xmz.2_RNA	NM_006809	NP_006800	Q15785	TOM34_HUMAN	translocase of outer mitochondrial membrane 34	76	TPR 2.				protein targeting to mitochondrion	integral to membrane|mitochondrial outer membrane	heat shock protein binding|signal sequence binding				0		Myeloproliferative disorder(115;0.0122)				GGCCACTTACGAAGTGCAATC	0.468		NA											14	203					0	0	0	0
SYCP2	10388	broad.mit.edu	37	20	58471566	58471566	+	Missense_Mutation	SNP	T	T	A			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr20:58471566T>A	uc002yaz.2	-	18	1561	c.1422A>T	c.(1420-1422)AAA>AAT	p.K474N		NM_014258	NP_055073	Q9BX26	SYCP2_HUMAN	synaptonemal complex protein 2	474					cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding			ovary(3)|lung(2)	5	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)			ACATTTTTCTTTTGCTAGGAG	0.318		NA											7	38					0	0	0	0
CCT8L2	150160	broad.mit.edu	37	22	17072504	17072504	+	Missense_Mutation	SNP	C	C	G			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr22:17072504C>G	uc002zlp.1	-	1	1197	c.937G>C	c.(937-939)GTG>CTG	p.V313L		NM_014406	NP_055221	Q96SF2	TCPQM_HUMAN	T-complex protein 1	313					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			ovary(1)	1	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				TGAATCACCACGATGCCATAC	0.557		NA											14	132					0	0	0	0
C22orf42	150297	broad.mit.edu	37	22	32548591	32548591	+	Silent	SNP	C	C	T			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr22:32548591C>T	uc003amd.2	-	3	371	c.330G>A	c.(328-330)GCG>GCA	p.A110A		NM_001010859	NP_001010859	Q6IC83	CV042_HUMAN	chromosome 22 open reading frame 42	110										ovary(1)|skin(1)	2						CGTGTGCAGACGCCTGCACAT	0.493		NA											6	46					0	0	0	0
SLC6A6	6533	broad.mit.edu	37	3	14526472	14526472	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr3:14526472C>T	uc010heg.2	+	22	2111	c.1820C>T	c.(1819-1821)GCT>GTT	p.A607V	SLC6A6_uc003byq.2_Missense_Mutation_p.A607V|SLC6A6_uc003byr.2_RNA	NM_001134367	NP_001127839	P31641	SC6A6_HUMAN	solute carrier family 6 (neurotransmitter	607	Cytoplasmic (Potential).				cellular amino acid metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity|taurine:sodium symporter activity			ovary(1)	1						ATGAACGGCGCTCTCGTGAAA	0.577		NA											3	22					0	0	0	0
GRM2	2912	broad.mit.edu	37	3	51743211	51743211	+	Missense_Mutation	SNP	G	G	A	rs144180122	by1000genomes	TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr3:51743211G>A	uc010hlv.2	+	2	451	c.212G>A	c.(211-213)CGC>CAC	p.R71H	GRM2_uc003dbo.3_Intron|GRM2_uc010hlu.2_RNA	NM_000839	NP_000830	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2 isoform a	71	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	GCACTGGACCGCATCAACCGT	0.632		NA											8	89					0	0	0	0
SLC4A4	8671	broad.mit.edu	37	4	72412192	72412192	+	Silent	SNP	G	G	A			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr4:72412192G>A	uc003hfy.2	+	19	2685	c.2568G>A	c.(2566-2568)AAG>AAA	p.K856K	SLC4A4_uc010iic.2_Silent_p.K856K|SLC4A4_uc010iib.2_Intron|SLC4A4_uc003hfz.2_Silent_p.K856K|SLC4A4_uc003hgc.3_Silent_p.K812K|SLC4A4_uc010iid.2_Silent_p.K60K	NM_001098484	NP_001091954	Q9Y6R1	S4A4_HUMAN	solute carrier family 4, sodium bicarbonate	856	Extracellular (Potential).			K -> R (in Ref. 4; AAG47773).		basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|kidney(1)|skin(1)	5			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			ACAGTTTGAAGATGGAGACAG	0.483		NA											6	46					0	0	0	0
LRBA	987	broad.mit.edu	37	4	151509256	151509256	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr4:151509256C>T	uc010ipj.2	-	41	6781	c.6307G>A	c.(6307-6309)GAA>AAA	p.E2103K	LRBA_uc003ilt.3_Missense_Mutation_p.E751K|LRBA_uc003ilu.3_Missense_Mutation_p.E2092K	NM_006726	NP_006717	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and	2103						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)					AAATAGAGTTCGGAGGAGGTG	0.463		NA											10	91					0	0	0	0
SLC38A9	153129	broad.mit.edu	37	5	54922346	54922346	+	Missense_Mutation	SNP	G	G	T			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr5:54922346G>T	uc003jqf.2	-	16	1863	c.1662C>A	c.(1660-1662)AAC>AAA	p.N554K	SLC38A9_uc003jqd.2_Missense_Mutation_p.N491K|SLC38A9_uc010ivx.2_Missense_Mutation_p.N491K|SLC38A9_uc003jqe.2_RNA|SLC38A9_uc010ivy.2_Missense_Mutation_p.N425K	NM_173514	NP_775785	Q8NBW4	S38A9_HUMAN	solute carrier family 38, member 9	554	Helical; (Potential).				amino acid transport|sodium ion transport	integral to membrane					0		Lung NSC(810;0.00122)|Prostate(74;0.0376)|Breast(144;0.181)				GAACAATCAGGTTAGCCACGC	0.368		NA											12	86					0.000978159	0.00124859	1	0
DDX4	54514	broad.mit.edu	37	5	55110956	55110956	+	Missense_Mutation	SNP	C	C	T			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr5:55110956C>T	uc003jqg.3	+	20	2017	c.1943C>T	c.(1942-1944)TCG>TTG	p.S648L	DDX4_uc010ivz.2_Missense_Mutation_p.S628L|DDX4_uc003jqh.3_Missense_Mutation_p.S614L|DDX4_uc003jqj.2_Missense_Mutation_p.S499L	NM_001136034	NP_001129506	Q9NQI0	DDX4_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform	648	Helicase C-terminal.				multicellular organismal development|sperm motility	perinuclear region of cytoplasm|pi-body|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|skin(1)	2		Lung NSC(810;6.93e-05)|all_neural(839;0.00409)|Prostate(74;0.0107)|Breast(144;0.0544)|Ovarian(174;0.223)				GATCTTGAATCGGATAACCAT	0.358		NA											6	104					0	0	0	0
HTR1A	3350	broad.mit.edu	37	5	63256816	63256816	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr5:63256816G>A	uc011cqt.1	-	1	731	c.731C>T	c.(730-732)GCA>GTA	p.A244V		NM_000524	NP_000515	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A	244	Cytoplasmic (By similarity).			A -> AA (in Ref. 8).	behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			ovary(2)|pancreas(2)	4		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	GGCGGGAGATGCTCCATGGCG	0.632		NA											8	56					0	0	0	0
PCSK1	5122	broad.mit.edu	37	5	95746485	95746485	+	Missense_Mutation	SNP	T	T	A			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr5:95746485T>A	uc003kls.1	-	8	1294	c.1088A>T	c.(1087-1089)CAG>CTG	p.Q363L	PCSK1_uc010jbi.1_Intron	NM_000439	NP_000430	P29120	NEC1_HUMAN	proprotein convertase subtilisin/kexin type 1	363	Catalytic.				cell-cell signaling|cellular nitrogen compound metabolic process|energy reserve metabolic process|hormone biosynthetic process|peptide biosynthetic process|peptide hormone processing|regulation of insulin secretion	extracellular space|stored secretory granule|transport vesicle	serine-type endopeptidase activity			ovary(2)	2		all_cancers(142;2.67e-06)|all_epithelial(76;6.92e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0112)|Colorectal(57;0.0341)|Breast(839;0.244)		all cancers(79;3.44e-16)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TACGATTCTCTGGTCGGTGTA	0.512		NA											10	80					0	0	0	0
KDM3B	51780	broad.mit.edu	37	5	137727180	137727180	+	Missense_Mutation	SNP	A	A	G			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr5:137727180A>G	uc003lcy.1	+	8	2059	c.1859A>G	c.(1858-1860)AAT>AGT	p.N620S	KDM3B_uc010jew.1_Missense_Mutation_p.N276S|KDM3B_uc011cys.1_Intron	NM_016604	NP_057688	Q7LBC6	KDM3B_HUMAN	jumonji domain containing 1B	620					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(3)|upper_aerodigestive_tract(2)|lung(2)|kidney(2)|central_nervous_system(1)|skin(1)	11						AATCATGAAAATCTATTTTTA	0.507		NA											13	104					0	0	0	0
PCDHGB3	56102	broad.mit.edu	37	5	140751490	140751490	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr5:140751490G>A	uc003ljw.1	+	1	1529	c.1529G>A	c.(1528-1530)CGG>CAG	p.R510Q	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGA6_uc003ljy.1_5'Flank|PCDHGB3_uc011dat.1_Missense_Mutation_p.R510Q|PCDHGA6_uc011dau.1_5'Flank	NM_018924	NP_061747	Q9Y5G1	PCDGF_HUMAN	protocadherin gamma subfamily B, 3 isoform 1	510	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGAGCGCGCGGAGCGGGGTG	0.667		NA											10	50					0	0	0	0
FAM193B	54540	broad.mit.edu	37	5	176951739	176951739	+	Silent	SNP	G	G	A			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr5:176951739G>A	uc003mhs.3	-	8	3233	c.1644C>T	c.(1642-1644)AAC>AAT	p.N548N	FAM193B_uc003mhr.2_Silent_p.N85N|FAM193B_uc003mht.2_Silent_p.N207N|FAM193B_uc003mhu.2_Silent_p.N260N|FAM193B_uc003mhv.2_Silent_p.N207N|FAM193B_uc003mhw.2_RNA	NM_019057	NP_061930	E9PET5	E9PET5_HUMAN	hypothetical protein LOC54540	581											0						TCACGAGCCCGTTCTCGGGGA	0.652		NA											4	8					0	0	0	0
HIST1H2BM	8342	broad.mit.edu	37	6	27783137	27783137	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr6:27783137G>A	uc003njo.2	+	1	316	c.316G>A	c.(316-318)GAA>AAA	p.E106K	HIST1H2AJ_uc003njn.1_5'Flank	NM_003521	NP_003512	Q99879	H2B1M_HUMAN	histone cluster 1, H2bm	106					nucleosome assembly	nucleosome|nucleus	DNA binding			large_intestine(1)	1						GCTACCCGGGGAATTGGCCAA	0.622		NA											7	60					0	0	0	0
TRIM27	5987	broad.mit.edu	37	6	28871857	28871857	+	Missense_Mutation	SNP	G	G	C			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr6:28871857G>C	uc003nlr.2	-	8	1891	c.1532C>G	c.(1531-1533)ACC>AGC	p.T511S	TRIM27_uc003nls.2_3'UTR|TRIM27_uc003nlt.1_3'UTR	NM_006510	NP_006501	P14373	TRI27_HUMAN	ret finger protein	511					cell proliferation|negative regulation of gene expression, epigenetic|negative regulation of transcription from RNA polymerase II promoter|protein trimerization|spermatogenesis|transcription, DNA-dependent	cytoplasm|integral to plasma membrane|membrane fraction|nuclear membrane|PML body	DNA binding|protein binding|transmembrane receptor protein tyrosine kinase activity|zinc ion binding			ovary(1)	1						TCAAGGGGAGGTCTCCATGGA	0.537		NA	T	RET	papillary thyroid								9	60					0	0	0	0
VARS2	57176	broad.mit.edu	37	6	30888896	30888896	+	Nonsense_Mutation	SNP	C	C	T			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr6:30888896C>T	uc003nsc.1	+	15	2166	c.1534C>T	c.(1534-1536)CAG>TAG	p.Q512*	VARS2_uc011dmx.1_Nonsense_Mutation_p.Q512*|VARS2_uc011dmy.1_Nonsense_Mutation_p.Q372*|VARS2_uc011dmz.1_Nonsense_Mutation_p.Q542*|VARS2_uc011dna.1_Nonsense_Mutation_p.Q510*|VARS2_uc011dnb.1_RNA|VARS2_uc011dnc.1_RNA|VARS2_uc011dnd.1_5'UTR|VARS2_uc010jsg.1_5'UTR|VARS2_uc010jsh.1_5'Flank	NM_020442	NP_065175	Q5ST30	SYVM_HUMAN	valyl-tRNA synthetase 2, mitochondrial	512					valyl-tRNA aminoacylation	mitochondrion	ATP binding|valine-tRNA ligase activity			ovary(3)|central_nervous_system(1)	4						GAAGAACTGGCAGCACTGGTT	0.557		NA											6	45					0	0	0	0
HLA-B	3106	broad.mit.edu	37	6	31324908	31324908	+	Missense_Mutation	SNP	G	G	T			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr6:31324908G>T	uc003nth.2	-	1	82	c.28C>A	c.(28-30)CTC>ATC	p.L10I	HLA-C_uc003ntb.2_5'Flank|HLA-C_uc003ntc.1_5'Flank|HLA-B_uc010jsm.1_5'Flank|HLA-B_uc011dnk.1_5'Flank|HLA-B_uc003ntf.2_Missense_Mutation_p.L10I|HLA-B_uc003ntg.1_5'Flank|HLA-B_uc003nti.1_5'Flank|HLA-B_uc010jsn.1_5'Flank|HLA-B_uc010jso.2_5'Flank	NM_005514	NP_005505	P01889	1B07_HUMAN	major histocompatibility complex, class I, B	10					antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity				0						AGCAGCAGGAGGACGGTTCGG	0.697		NA							Melanoma_Familial_Clustering_of|Lichen_Sclerosis_et_Atrophicus_Familial_Clustering_of				4	10					0.000602214	0.00077786	1	0
SLC44A4	80736	broad.mit.edu	37	6	31832499	31832499	+	Silent	SNP	C	C	A			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr6:31832499C>A	uc010jti.2	-	20	2007	c.1941G>T	c.(1939-1941)GGG>GGT	p.G647G	NEU1_uc003nxq.3_5'Flank|NEU1_uc010jtg.2_5'Flank|NEU1_uc003nxr.3_5'Flank|NEU1_uc010jth.2_5'Flank|NEU1_uc003nxs.3_5'Flank	NM_025257	NP_079533	Q53GD3	CTL4_HUMAN	choline transporter-like protein 4	647	Helical; (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4					Choline(DB00122)	TGACATAGGCCCCCAGGATGG	0.597		NA											7	79					8.13e-05	0.000108878	1	0
DNAH8	1769	broad.mit.edu	37	6	38840791	38840791	+	Silent	SNP	C	C	T			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr6:38840791C>T	uc003ooe.1	+	49	7296	c.6696C>T	c.(6694-6696)CGC>CGT	p.R2232R		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						ATGGAGATCGCATTCCCATGG	0.443		NA											12	82					0	0	0	0
KIAA0776	23376	broad.mit.edu	37	6	96971059	96971059	+	Silent	SNP	T	T	C			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr6:96971059T>C	uc003por.2	+	2	163	c.115T>C	c.(115-117)TTG>CTG	p.L39L	KIAA0776_uc010kck.2_RNA	NM_015323	NP_056138	O94874	UFL1_HUMAN	hypothetical protein LOC23376	39	Required for E3 UFM1-protein ligase activity.				negative regulation of NF-kappaB transcription factor activity|negative regulation of protein ubiquitination|protein ufmylation	endoplasmic reticulum|nucleus	protein binding|UFM1 conjugating enzyme activity			ovary(1)	1		all_cancers(76;5.83e-05)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.0604)|Colorectal(196;0.0721)		BRCA - Breast invasive adenocarcinoma(108;0.0934)		TGTTAATAAATTGATTGCTCA	0.368		NA											5	88					0	0	0	0
HEY2	23493	broad.mit.edu	37	6	126080842	126080842	+	Missense_Mutation	SNP	T	T	G			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr6:126080842T>G	uc003qad.2	+	5	1099	c.908T>G	c.(907-909)ATC>AGC	p.I303S	HEY2_uc011ebr.1_Missense_Mutation_p.I257S	NM_012259	NP_036391	Q9UBP5	HEY2_HUMAN	hairy/enhancer-of-split related with YRPW motif	303					negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription initiation from RNA polymerase II promoter|negative regulation of transcription regulatory region DNA binding|Notch signaling pathway|smooth muscle cell differentiation|transcription, DNA-dependent	transcriptional repressor complex	histone deacetylase binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding			breast(1)	1				UCEC - Uterine corpus endometrioid carcinoma (4;0.0608)|GBM - Glioblastoma multiforme(226;0.0361)|all cancers(137;0.193)		GCCACAGCCATCAGCCCGCCC	0.622		NA											10	106					0	0	0	0
FAM49B	51571	broad.mit.edu	37	8	130874554	130874554	+	Missense_Mutation	SNP	C	C	G			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr8:130874554C>G	uc003yss.2	-	8	771	c.222G>C	c.(220-222)AAG>AAC	p.K74N	FAM49B_uc003yst.2_Missense_Mutation_p.K74N|FAM49B_uc003ysu.2_Missense_Mutation_p.K74N|FAM49B_uc003ysv.2_Intron|FAM49B_uc003ysw.2_Missense_Mutation_p.K74N|FAM49B_uc003ysx.2_Missense_Mutation_p.K74N|FAM49B_uc003ysy.1_Missense_Mutation_p.K74N	NM_016623	NP_057707	Q9NUQ9	FA49B_HUMAN	hypothetical protein LOC51571	74											0	Ovarian(5;0.000567)|Esophageal squamous(12;0.00693)|Acute lymphoblastic leukemia(118;0.155)		LUAD - Lung adenocarcinoma(14;0.0989)			TCTCTTGCAACTTCTCATCTG	0.328		NA											8	87					0	0	0	0
PAX5	5079	broad.mit.edu	37	9	37015073	37015073	+	Missense_Mutation	SNP	C	C	A			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr9:37015073C>A	uc003zzo.1	-	3	779	c.331G>T	c.(331-333)GCC>TCC	p.A111S	PAX5_uc011lpw.1_Missense_Mutation_p.A111S|PAX5_uc011lpx.1_Intron|PAX5_uc011lpy.1_Missense_Mutation_p.A3S|PAX5_uc010mls.1_Missense_Mutation_p.A111S|PAX5_uc011lpz.1_Missense_Mutation_p.A111S|PAX5_uc011lqa.1_Missense_Mutation_p.A3S|PAX5_uc010mlq.1_RNA|PAX5_uc011lqb.1_RNA|PAX5_uc010mlo.1_Missense_Mutation_p.A111S|PAX5_uc010mlp.1_Missense_Mutation_p.A111S|PAX5_uc011lqc.1_Missense_Mutation_p.A111S|PAX5_uc010mlr.1_Missense_Mutation_p.A111S|PAX5_uc011lqd.1_Intron|PAX5_uc011lqe.1_RNA|PAX5_uc011lqf.1_Intron|PAX5_uc011lqg.1_RNA	NM_016734	NP_057953	Q02548	PAX5_HUMAN	paired box 5	111	Paired.				cell differentiation|humoral immune response|nervous system development|organ morphogenesis|spermatogenesis|transcription from RNA polymerase II promoter	nucleus	DNA binding	p.?(32)	PAX5/JAK2(18)	haematopoietic_and_lymphoid_tissue(142)|lung(3)|central_nervous_system(2)	147		all_cancers(2;3.46e-10)|Acute lymphoblastic leukemia(2;7.09e-56)|all_hematologic(2;6.65e-44)		GBM - Glioblastoma multiforme(29;0.0108)		ATCTCCCAGGCAAACATGGTG	0.547		NA	T|Mis|D|F|S	IGH@|ETV6|PML|FOXP1|ZNF521|ELN	NHL|ALL|B-ALL								8	179					0.00448238	0.0056551	1	0
KIAA1529	57653	broad.mit.edu	37	9	100127991	100127991	+	Missense_Mutation	SNP	G	G	T			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr9:100127991G>T	uc011lut.1	+	42	5339	c.4566G>T	c.(4564-4566)GAG>GAT	p.E1522D	KIAA1529_uc004axe.1_Missense_Mutation_p.E1328D|KIAA1529_uc004axg.1_Missense_Mutation_p.E1383D|KIAA1529_uc004axh.1_RNA|KIAA1529_uc011luw.1_Missense_Mutation_p.E476D|MIR1302-8_hsa-mir-1302-8|MI0006369_5'Flank	NM_020893	NP_065944			hypothetical protein LOC57653											ovary(4)|large_intestine(2)|skin(1)	7		Acute lymphoblastic leukemia(62;0.154)				TCCTCTGGGAGAGCAGTGAGA	0.562		NA											16	54					2e-07	2.78e-07	1	0
SCML1	6322	broad.mit.edu	37	X	17768243	17768243	+	Missense_Mutation	SNP	C	C	G			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chrX:17768243C>G	uc004cyb.2	+	6	858	c.533C>G	c.(532-534)ACT>AGT	p.T178S	SCML1_uc004cyc.2_Missense_Mutation_p.T151S|SCML1_uc004cyd.2_Missense_Mutation_p.T57S|SCML1_uc004cye.2_Missense_Mutation_p.T57S	NM_001037540	NP_001032629	Q9UN30	SCML1_HUMAN	sex comb on midleg-like 1 isoform a	178					anatomical structure morphogenesis	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|ovary(1)	3	Hepatocellular(33;0.183)					CTCAGCCGCACTCCGAGTCCA	0.522		NA											16	71					0	0	0	0
BRWD3	254065	broad.mit.edu	37	X	79932674	79932674	+	Missense_Mutation	SNP	A	A	G			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chrX:79932674A>G	uc004edt.2	-	41	5106	c.4843T>C	c.(4843-4845)TCT>CCT	p.S1615P	BRWD3_uc010nmi.1_RNA|BRWD3_uc004edo.2_Missense_Mutation_p.S1211P|BRWD3_uc004edp.2_Missense_Mutation_p.S1444P|BRWD3_uc004edq.2_Missense_Mutation_p.S1211P|BRWD3_uc010nmj.1_Missense_Mutation_p.S1211P|BRWD3_uc004edr.2_Missense_Mutation_p.S1285P|BRWD3_uc004eds.2_Missense_Mutation_p.S1211P|BRWD3_uc004edu.2_Missense_Mutation_p.S1285P|BRWD3_uc004edv.2_Missense_Mutation_p.S1211P|BRWD3_uc004edw.2_Missense_Mutation_p.S1211P|BRWD3_uc004edx.2_Missense_Mutation_p.S1211P|BRWD3_uc004edy.2_Missense_Mutation_p.S1211P|BRWD3_uc004edz.2_Missense_Mutation_p.S1285P|BRWD3_uc004eea.2_Missense_Mutation_p.S1285P|BRWD3_uc004eeb.2_Missense_Mutation_p.S1211P|uc004edn.1_5'Flank	NM_153252	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	1615										ovary(4)	4						GTACTTTCAGAACTTAAACTG	0.294		NA											5	136					0	0	0	0
PCDH11X	27328	broad.mit.edu	37	X	91132437	91132437	+	Missense_Mutation	SNP	A	A	G			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chrX:91132437A>G	uc004efk.1	+	2	2043	c.1198A>G	c.(1198-1200)ACA>GCA	p.T400A	PCDH11X_uc004efl.1_Missense_Mutation_p.T400A|PCDH11X_uc004efo.1_Missense_Mutation_p.T400A|PCDH11X_uc010nmv.1_Missense_Mutation_p.T400A|PCDH11X_uc004efm.1_Missense_Mutation_p.T400A|PCDH11X_uc004efn.1_Missense_Mutation_p.T400A|PCDH11X_uc004efh.1_Missense_Mutation_p.T400A|PCDH11X_uc004efj.1_Missense_Mutation_p.T400A	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	400	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						GACATGCTTCACAGATCATGA	0.418		NA											9	121					0	0	0	0
GPR112	139378	broad.mit.edu	37	X	135405364	135405364	+	Missense_Mutation	SNP	T	T	A			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chrX:135405364T>A	uc004ezu.1	+	5	789	c.498T>A	c.(496-498)AAT>AAA	p.N166K	GPR112_uc010nsb.1_Intron	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	166	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					TTCTCAAGAATGAGAGCAGCG	0.448		NA											7	129					0	0	0	0
FLNA	2316	broad.mit.edu	37	X	153594747	153594747	+	Missense_Mutation	SNP	G	G	A			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chrX:153594747G>A	uc004fkk.2	-	8	1406	c.1157C>T	c.(1156-1158)GCC>GTC	p.A386V	FLNA_uc010nuu.1_Missense_Mutation_p.A386V	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	386	Filamin 2.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GGGACCTTGGGCTGTCACTTT	0.597		NA											7	58					0	0	0	0
ABCC3	8714	broad.mit.edu	37	17	48761081	48761082	+	Frame_Shift_Del	DEL	GA	GA	-			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr17:48761081_48761082delGA	uc002isl.2	+	27	3998_3999	c.3918_3919delGA	c.(3916-3921)CTGAGAfs	p.L1306fs	ABCC3_uc002isn.2_Frame_Shift_Del_p.L60fs	NM_003786	NP_003777	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C, member 3	1306_1307	Cytoplasmic (By similarity).|ABC transporter 2.				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			skin(3)|central_nervous_system(1)	4			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	ACCTGGTGCTGAGAGACCTGAG	0.644		NA											15	77	---	---	---	---	NA	NA	NA	NA
DNAH8	1769	broad.mit.edu	37	6	38816439	38816440	+	Frame_Shift_Ins	INS	-	-	A			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr6:38816439_38816440insA	uc003ooe.1	+	35	5010_5011	c.4410_4411insA	c.(4408-4413)TTTAAAfs	p.F1470fs		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						ATGCTCCATTTAAAAAAAATAT	0.342		NA											7	31	---	---	---	---	NA	NA	NA	NA
AKAP9	10142	broad.mit.edu	37	7	91570433	91570435	+	In_Frame_Del	DEL	AGA	AGA	-			TCGA-IQ-7632-01A-11D-2078-08	TCGA-IQ-7632-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9fcfc377-a153-401c-95b4-8a4569866096	a469cc49-769d-4e13-ad08-591a3792926e	g.chr7:91570433_91570435delAGA	uc003ulg.2	+	1	245_247	c.20_22delAGA	c.(19-24)CAGAAG>CAG	p.K9del	AKAP9_uc003uld.3_In_Frame_Del_p.K9del|AKAP9_uc003ule.2_In_Frame_Del_p.K9del|AKAP9_uc003ulf.2_In_Frame_Del_p.K9del	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	9					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			GAGGAGAGACAGAAGAAGCTGGA	0.635		NA	T	BRAF	papillary thyroid								12	108	---	---	---	---	NA	NA	NA	NA