Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
TTLL10	254173	broad.mit.edu	37	1	1117129	1117129	+	Missense_Mutation	SNP	A	A	T			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr1:1117129A>T	uc001acy.2	+	9	915	c.764A>T	c.(763-765)AAG>ATG	p.K255M	uc001acx.1_5'Flank|TTLL10_uc010nyg.1_Missense_Mutation_p.K255M|TTLL10_uc001acz.1_Missense_Mutation_p.K182M	NM_001130045	NP_001123517	Q6ZVT0	TTL10_HUMAN	tubulin tyrosine ligase-like family, member 10	255	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity			large_intestine(1)	1	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;4.75e-36)|OV - Ovarian serous cystadenocarcinoma(86;5.82e-22)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;4.22e-05)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		AGGCTGGAAAAGGACGCAGCA	0.672		NA											3	12					0	0	0	0
JAK1	3716	broad.mit.edu	37	1	65303626	65303627	+	Missense_Mutation	DNP	GC	GC	AA			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr1:65303626_65303627GC>AA	uc001dbu.1	-	22	3377_3378	c.3128_3129GC>TT	c.(3127-3129)AGC>ATT	p.S1043I	JAK1_uc009wam.1_Missense_Mutation_p.S1031I|JAK1_uc009wal.1_Missense_Mutation_p.S220I	NM_002227	NP_002218	P23458	JAK1_HUMAN	janus kinase 1	1043	Protein kinase 2.				interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to antibiotic|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|endomembrane system|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			haematopoietic_and_lymphoid_tissue(34)|prostate(7)|soft_tissue(6)|lung(4)|breast(3)|central_nervous_system(2)|liver(2)|large_intestine(1)|stomach(1)|ovary(1)	61				BRCA - Breast invasive adenocarcinoma(111;0.0485)		AAAACACAGGGCTGTCCCGGTC	0.401		NA	Mis		ALL								3	52					0	0	0	0
JAK1	3716	broad.mit.edu	37	1	65306941	65306941	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr1:65306941C>T	uc001dbu.1	-	19	2885	c.2636G>A	c.(2635-2637)CGT>CAT	p.R879H	JAK1_uc009wam.1_Missense_Mutation_p.R867H|JAK1_uc009wal.1_Missense_Mutation_p.R56H	NM_002227	NP_002218	P23458	JAK1_HUMAN	janus kinase 1	879	Protein kinase 2.				interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to antibiotic|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|endomembrane system|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity	p.R879S(1)|p.R879C(1)|p.R879H(1)		haematopoietic_and_lymphoid_tissue(34)|prostate(7)|soft_tissue(6)|lung(4)|breast(3)|central_nervous_system(2)|liver(2)|large_intestine(1)|stomach(1)|ovary(1)	61				BRCA - Breast invasive adenocarcinoma(111;0.0485)		TCCCAAGTCACGGATCCTCTT	0.493		NA	Mis		ALL								9	70					0	0	0	0
MSH4	4438	broad.mit.edu	37	1	76365359	76365359	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr1:76365359G>A	uc001dhd.1	+	19	2628	c.2587G>A	c.(2587-2589)GAA>AAA	p.E863K		NM_002440	NP_002431	O15457	MSH4_HUMAN	mutS homolog 4	863					chiasma assembly|homologous chromosome segregation|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			lung(3)|ovary(2)	5						GGATGCCAAGGAAATCACAAC	0.294		NA						MMR					8	66					0	0	0	0
MTMR11	10903	broad.mit.edu	37	1	149905361	149905361	+	Missense_Mutation	SNP	T	T	C			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr1:149905361T>C	uc001etl.3	-	10	1174	c.923A>G	c.(922-924)GAG>GGG	p.E308G	MTMR11_uc001etm.1_Missense_Mutation_p.E236G|MTMR11_uc010pbm.1_Missense_Mutation_p.E280G|MTMR11_uc010pbn.1_Missense_Mutation_p.E150G	NM_001145862	NP_001139334	A4FU01	MTMRB_HUMAN	myotubularin related protein 11 isoform a	308	Myotubularin phosphatase.						phosphatase activity			central_nervous_system(1)	1	Breast(34;0.0009)|Ovarian(49;0.0377)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)			GCTGGGCAGCTCATCCATAGT	0.567		NA											3	79					0	0	0	0
ANP32E	81611	broad.mit.edu	37	1	150202922	150202922	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr1:150202922C>G	uc001etw.2	-	3	681	c.311G>C	c.(310-312)AGT>ACT	p.S104T	ANP32E_uc010pbu.1_Missense_Mutation_p.S56T|ANP32E_uc010pbv.1_Intron|ANP32E_uc001etv.3_Missense_Mutation_p.S104T|ANP32E_uc010pbw.1_Missense_Mutation_p.S104T	NM_030920	NP_112182	Q9BTT0	AN32E_HUMAN	acidic (leucine-rich) nuclear phosphoprotein 32	104	LRR 4.					cytoplasmic membrane-bounded vesicle|nucleus	phosphatase inhibitor activity				0	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			TTCTACTGTACTGAGATCTTT	0.343		NA											7	57					0	0	0	0
LRP5	4041	broad.mit.edu	37	11	68133078	68133078	+	Missense_Mutation	SNP	A	A	C			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr11:68133078A>C	uc001ont.2	+	5	998	c.923A>C	c.(922-924)CAC>CCC	p.H308P	LRP5_uc009ysg.2_5'UTR	NM_002335	NP_002326	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein	308	EGF-like 1.|Extracellular (Potential).				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			lung(2)|skin(2)|ovary(1)|pancreas(1)|breast(1)	7						GGCTGCTCCCACCTGTGCCTG	0.587		NA											8	104					0	0	0	0
CD163	9332	broad.mit.edu	37	12	7636017	7636017	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr12:7636017G>A	uc001qsz.3	-	12	3162	c.3034C>T	c.(3034-3036)CGC>TGC	p.R1012C	CD163_uc001qta.3_Missense_Mutation_p.R1012C|CD163_uc009zfw.2_Missense_Mutation_p.R1045C	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	1012	SRCR 9.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						TGGCCCCAGCGTCTGGCAGGA	0.512		NA											7	50					0	0	0	0
KRT78	196374	broad.mit.edu	37	12	53233611	53233611	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr12:53233611G>A	uc001sbc.1	-	7	1269	c.1205C>T	c.(1204-1206)ACG>ATG	p.T402M		NM_173352	NP_775487	Q8N1N4	K2C78_HUMAN	keratin 5b	402	Coil 2.|Rod.					keratin filament	protein binding|structural molecule activity			ovary(2)	2						GGAAAGCTTCGTGCTCGTCAG	0.612		NA											9	59					0	0	0	0
CSNK1A1L	122011	broad.mit.edu	37	13	37679304	37679304	+	Silent	SNP	G	G	A			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr13:37679304G>A	uc001uwm.1	-	1	498	c.90C>T	c.(88-90)GAC>GAT	p.D30D		NM_145203	NP_660204	Q8N752	KC1AL_HUMAN	casein kinase 1, alpha 1-like	30	ATP (By similarity).|Protein kinase.				Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity			large_intestine(1)	1		Lung NSC(96;7.97e-05)|Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.109)		all cancers(112;3.58e-07)|Epithelial(112;1.29e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00695)|BRCA - Breast invasive adenocarcinoma(63;0.0117)|GBM - Glioblastoma multiforme(144;0.0407)		CCAGATAAACGTCTCCAAAGG	0.537		NA											7	122					0	0	0	0
FARP1	10160	broad.mit.edu	37	13	99042297	99042297	+	Silent	SNP	C	C	A			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr13:99042297C>A	uc001vnj.2	+	10	1278	c.942C>A	c.(940-942)GCC>GCA	p.A314A	FARP1_uc001vnh.2_Silent_p.A314A	NM_005766	NP_005757	Q9Y4F1	FARP1_HUMAN	FERM, RhoGEF, and pleckstrin domain protein 1	314	FERM.				regulation of Rho protein signal transduction	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			AACATCATGCCTTCTTTAGAC	0.488		NA											7	155					2.01e-06	2.31e-06	1	0
RASA3	22821	broad.mit.edu	37	13	114751137	114751137	+	Missense_Mutation	SNP	T	T	C			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr13:114751137T>C	uc001vui.2	-	23	2509	c.2378A>G	c.(2377-2379)GAG>GGG	p.E793G	RASA3_uc010tkk.1_Missense_Mutation_p.E761G|RASA3_uc001vuj.2_Missense_Mutation_p.E410G	NM_007368	NP_031394	Q14644	RASA3_HUMAN	RAS p21 protein activator 3	793					intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	calcium-release channel activity|metal ion binding|Ras GTPase activator activity			lung(3)|skin(1)	4	Lung NSC(43;0.00814)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.016)|all_epithelial(44;0.00577)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.188)	BRCA - Breast invasive adenocarcinoma(86;0.128)			CTGGGCGTGCTCCTGCTCCAA	0.582		NA											15	183					0	0	0	0
MAP3K9	4293	broad.mit.edu	37	14	71205084	71205084	+	Silent	SNP	G	G	A			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr14:71205084G>A	uc001xmm.2	-	8	1722	c.1722C>T	c.(1720-1722)GGC>GGT	p.G574G	MAP3K9_uc010ttk.1_Silent_p.G311G|MAP3K9_uc001xmk.2_Silent_p.G316G|MAP3K9_uc001xml.2_Silent_p.G574G	NM_033141	NP_149132	P80192	M3K9_HUMAN	mitogen-activated protein kinase kinase kinase	574					activation of JUN kinase activity|protein autophosphorylation		ATP binding|JUN kinase kinase kinase activity|MAP kinase kinase activity|protein homodimerization activity			stomach(2)|lung(1)|central_nervous_system(1)|skin(1)	5				all cancers(60;0.00779)|BRCA - Breast invasive adenocarcinoma(234;0.00884)|OV - Ovarian serous cystadenocarcinoma(108;0.08)		CTGAGCTCCTGCCccaggttt	0.328		NA											11	77					0	0	0	0
C14orf179	112752	broad.mit.edu	37	14	76525675	76525675	+	Missense_Mutation	SNP	G	G	A	rs2302858	by1000genomes	TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr14:76525675G>A	uc010asm.1	+	5	288	c.254G>A	c.(253-255)CGC>CAC	p.R85H	C14orf179_uc001xsf.2_RNA|C14orf179_uc010asl.1_Missense_Mutation_p.R85H|C14orf179_uc001xsg.2_Intron|C14orf179_uc010tve.1_RNA	NM_001102564	NP_001096034	Q96FT9	IFT43_HUMAN	hypothetical protein LOC112752 isoform 2	85					cilium morphogenesis|intraflagellar retrograde transport						0				BRCA - Breast invasive adenocarcinoma(234;0.0199)		GGCAGTTTCCGCCTCAGACCA	0.448		NA											7	85					0	0	0	0
ATP8B4	79895	broad.mit.edu	37	15	50215663	50215663	+	Silent	SNP	A	A	C			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr15:50215663A>C	uc001zxu.2	-	17	1813	c.1671T>G	c.(1669-1671)CTT>CTG	p.L557L	ATP8B4_uc010ber.2_Silent_p.L430L|ATP8B4_uc010ufd.1_Silent_p.L367L|ATP8B4_uc010ufe.1_RNA	NM_024837	NP_079113	Q8TF62	AT8B4_HUMAN	ATPase class I type 8B member 4	557	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			skin(3)|ovary(2)|breast(2)|large_intestine(1)	8		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		CTTTGGAATAAAGCTTTATCT	0.383		NA											4	40					0	0	0	0
RFX7	64864	broad.mit.edu	37	15	56393703	56393703	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr15:56393703G>T	uc010bfn.2	-	7	665	c.665C>A	c.(664-666)GCT>GAT	p.A222D	RFX7_uc010ugk.1_RNA|RFX7_uc002adn.1_Missense_Mutation_p.A36D	NM_022841	NP_073752	Q2KHR2	RFX7_HUMAN	regulatory factor X domain containing 2	125					regulation of transcription, DNA-dependent	nucleus	DNA binding				0						AAGACGGCAAGCAGAAGAGAT	0.423		NA											8	47					4.19e-16	4.91e-16	1	0
RAB11FIP3	9727	broad.mit.edu	37	16	546835	546835	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr16:546835G>A	uc002chf.2	+	6	1616	c.1277G>A	c.(1276-1278)CGG>CAG	p.R426Q	RAB11FIP3_uc010uuf.1_Missense_Mutation_p.R130Q|RAB11FIP3_uc010uug.1_Missense_Mutation_p.R161Q	NM_014700	NP_055515	O75154	RFIP3_HUMAN	rab11-family interacting protein 3 isoform 1	426					cell cycle|cytokinesis|endocytic recycling|protein transport	centrosome|cleavage furrow|midbody|recycling endosome membrane	ADP-ribosylation factor binding|calcium ion binding|protein homodimerization activity|Rab GTPase binding				0		Hepatocellular(16;0.0218)				CCGACAAAGCGGCTCTCCAGC	0.423		NA											13	92					0	0	0	0
MAPK8IP3	23162	broad.mit.edu	37	16	1815178	1815178	+	Silent	SNP	C	C	T			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr16:1815178C>T	uc002cmk.2	+	20	2562	c.2442C>T	c.(2440-2442)CCC>CCT	p.P814P	MAPK8IP3_uc002cml.2_Silent_p.P808P|MAPK8IP3_uc010uvl.1_Silent_p.P815P	NM_015133	NP_055948	Q9UPT6	JIP3_HUMAN	mitogen-activated protein kinase 8 interacting	814					vesicle-mediated transport	Golgi membrane	kinesin binding|MAP-kinase scaffold activity|protein kinase binding			breast(2)|central_nervous_system(1)	3						CCAGCATCCCCGGTGAGCAGC	0.617		NA											3	18					0	0	0	0
MYH11	4629	broad.mit.edu	37	16	15841500	15841500	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr16:15841500C>T	uc002ddy.2	-	19	2445	c.2338G>A	c.(2338-2340)GAG>AAG	p.E780K	MYH11_uc002ddv.2_Missense_Mutation_p.E787K|MYH11_uc002ddw.2_Missense_Mutation_p.E780K|MYH11_uc002ddx.2_Missense_Mutation_p.E787K|MYH11_uc010bvg.2_Missense_Mutation_p.E612K	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	780	Myosin head-like.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						TCTCGCTCCTCCTCTAGGTGG	0.498		NA	T	CBFB	AML								13	86					0	0	0	0
HS3ST4	9951	broad.mit.edu	37	16	26147117	26147117	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr16:26147117G>A	uc002dof.2	+	2	1311	c.919G>A	c.(919-921)GAG>AAG	p.E307K		NM_006040	NP_006031	Q9Y661	HS3S4_HUMAN	heparan sulfate D-glucosaminyl	307	Lumenal (Potential).				heparan sulfate proteoglycan metabolic process	extracellular region|Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity			large_intestine(1)|breast(1)	2				GBM - Glioblastoma multiforme(48;0.0988)		AAAGAAACCCGAGATCCCCAC	0.537		NA											21	165					0	0	0	0
KIAA0895L	653319	broad.mit.edu	37	16	67213451	67213451	+	Silent	SNP	C	C	G			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr16:67213451C>G	uc002ert.2	-	4	1504	c.729G>C	c.(727-729)CTG>CTC	p.L243L	KIAA0895L_uc002err.2_5'Flank|KIAA0895L_uc002ers.2_5'UTR|KIAA0895L_uc002eru.2_Silent_p.L243L|EXOC3L_uc002erv.1_RNA	NM_001040715	NP_001035805	Q68EN5	K895L_HUMAN	hypothetical protein LOC653319	243											0						GGTCCTCACTCAGCTGCACCA	0.647		NA											4	40					0	0	0	0
PELP1	27043	broad.mit.edu	37	17	4575883	4575883	+	Silent	SNP	T	T	G			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr17:4575883T>G	uc002fyi.3	-	16	2629	c.2403A>C	c.(2401-2403)CCA>CCC	p.P801P	PELP1_uc010vsf.1_Silent_p.P654P	NM_014389	NP_055204	Q8IZL8	PELP1_HUMAN	proline, glutamic acid and leucine rich protein	801	Pro-rich.				transcription, DNA-dependent	cytoplasm|MLL1 complex	protein binding			ovary(1)|central_nervous_system(1)	2						CTGAGGGTGGTGGGGGTGGCA	0.622		NA											4	27					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7577120	7577120	+	Missense_Mutation	SNP	C	C	T	rs28934576	by1000genomes	TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr17:7577120C>T	uc002gim.2	-	8	1012	c.818G>A	c.(817-819)CGT>CAT	p.R273H	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R273H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R141H|TP53_uc010cng.1_Missense_Mutation_p.R141H|TP53_uc002gii.1_Missense_Mutation_p.R141H|TP53_uc010cnh.1_Missense_Mutation_p.R273H|TP53_uc010cni.1_Missense_Mutation_p.R273H|TP53_uc002gij.2_Missense_Mutation_p.R273H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	273	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273H(469)|p.R273C(394)|p.R273L(83)|p.R273P(24)|p.R273S(11)|p.R273G(9)|p.0?(7)|p.R273fs*72(3)|p.?(2)|p.R273fs*33(2)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.R273R(1)|p.E258fs*71(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCACAAACACGCACCTCAAA	0.542	R273H(NCIH1793_LUNG)|R273H(MOLT13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(PANC1_PANCREAS)|R273H(NCIH508_LARGE_INTESTINE)|R273H(NCIH1975_LUNG)|R273H(U251MG_CENTRAL_NERVOUS_SYSTEM)|R273H(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273H(NCIH2405_LUNG)|R273H(HEC59_ENDOMETRIUM)|R273H(NCIH1155_LUNG)|R273H(HT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(EN_ENDOMETRIUM)|R273H(SNB19_CENTRAL_NERVOUS_SYSTEM)|R273H(MDAMB468_BREAST)|R273H(SUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SW620_LARGE_INTESTINE)|R273H(SUIT2_PANCREAS)|R273H(SW480_LARGE_INTESTINE)|R273H(SKMEL30_SKIN)|R273H(OC314_OVARY)|R273H(HEC6_ENDOMETRIUM)|R273H(HT29_LARGE_INTESTINE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			6	22					0	0	0	0
KRTAP4-1	85285	broad.mit.edu	37	17	39340710	39340710	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr17:39340710G>A	uc002hwe.3	-	2	381	c.340C>T	c.(340-342)CGT>TGT	p.R114C		NM_033060	NP_149049	Q9BYQ7	KRA41_HUMAN	keratin associated protein 4-1	133	16.|18 X 5 AA repeats of C-C-[GRQC]-[SPT]- [VSTL].					keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000449)			CAAGTTGCACGGCAGCAGGTG	0.577		NA											6	126					0	0	0	0
WFIKKN2	124857	broad.mit.edu	37	17	48917985	48917985	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr17:48917985C>T	uc002isv.3	+	2	2030	c.1336C>T	c.(1336-1338)CGG>TGG	p.R446W	WFIKKN2_uc010dbu.2_Missense_Mutation_p.R353W	NM_175575	NP_783165	Q8TEU8	WFKN2_HUMAN	WFIKKN2 protein	446	NTR.					extracellular region	metalloendopeptidase inhibitor activity|protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			CCAGCGCTGTCGGGCCTGCAA	0.622		NA											8	55					0	0	0	0
GDPD1	284161	broad.mit.edu	37	17	57298028	57298028	+	Missense_Mutation	SNP	T	T	C			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr17:57298028T>C	uc002ixk.1	+	1	195	c.58T>C	c.(58-60)TCA>CCA	p.S20P	GDPD1_uc002ixj.2_Missense_Mutation_p.S20P	NM_182569	NP_872375	Q8N9F7	GDPD1_HUMAN	glycerophosphodiester phosphodiesterase domain	20	Helical; (Potential).				glycerol metabolic process|lipid metabolic process	cytoplasm|integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding				0	all_neural(34;0.0837)|Medulloblastoma(34;0.0922)					CTTGGTGACCTCATTCTTGTT	0.542		NA									OREG0024617	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	137					0	0	0	0
LRRC37A3	374819	broad.mit.edu	37	17	62857035	62857035	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr17:62857035G>A	uc002jey.2	-	11	3760	c.3229C>T	c.(3229-3231)CGG>TGG	p.R1077W	LRRC37A3_uc010wqg.1_Missense_Mutation_p.R195W|LRRC37A3_uc002jex.1_Missense_Mutation_p.R54W|LRRC37A3_uc010wqf.1_Missense_Mutation_p.R115W|LRRC37A3_uc010dek.1_Missense_Mutation_p.R83W	NM_199340	NP_955372	O60309	L37A3_HUMAN	leucine rich repeat containing 37, member A3	1077	Extracellular (Potential).					integral to membrane					0						TAATTCTTCCGGGCTTGTAAC	0.483		NA											24	269					0	0	0	0
ARHGEF18	23370	broad.mit.edu	37	19	7531842	7531842	+	Silent	SNP	C	C	T			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr19:7531842C>T	uc002mgi.2	+	14	2632	c.2379C>T	c.(2377-2379)CCC>CCT	p.P793P	ARHGEF18_uc010xjm.1_Silent_p.P635P|ARHGEF18_uc002mgh.2_Silent_p.P635P|ARHGEF18_uc002mgj.1_Silent_p.P436P	NM_001130955	NP_001124427	Q6ZSZ5	ARHGI_HUMAN	Rho/Rac guanine nucleotide exchange factor 18	793					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell shape|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			ovary(1)	1		Renal(5;0.0902)				CCCGTCTGCCCACCGTCCTGG	0.637		NA											11	68					0	0	0	0
CD97	976	broad.mit.edu	37	19	14508888	14508888	+	Silent	SNP	C	C	T			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr19:14508888C>T	uc002myl.2	+	9	957	c.834C>T	c.(832-834)TTC>TTT	p.F278F	CD97_uc002mym.2_Silent_p.F229F|CD97_uc002myn.2_Silent_p.F185F	NM_078481	NP_510966	P48960	CD97_HUMAN	CD97 antigen isoform 1 precursor	278	Extracellular (Potential).				cell adhesion|cell-cell signaling|cellular component movement|immune response|inflammatory response|neuropeptide signaling pathway	extracellular space|integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(3)|breast(1)	4						TTTCCCGATTCTTCGACAAAG	0.587		NA											5	74					0	0	0	0
USHBP1	83878	broad.mit.edu	37	19	17373676	17373676	+	Silent	SNP	C	C	T			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr19:17373676C>T	uc002nfs.1	-	4	440	c.327G>A	c.(325-327)GTG>GTA	p.V109V	USHBP1_uc002nft.1_RNA|USHBP1_uc010xpk.1_Silent_p.V45V|USHBP1_uc010eam.1_Silent_p.V37V	NM_031941	NP_114147	Q8N6Y0	USBP1_HUMAN	Usher syndrome 1C binding protein 1	109							PDZ domain binding			ovary(1)	1						TCCCAGGGGGCACAGTCTCCT	0.667		NA											14	102					0	0	0	0
LYPD3	27076	broad.mit.edu	37	19	43965777	43965777	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr19:43965777G>A	uc002owl.1	-	5	875	c.767C>T	c.(766-768)ACC>ATC	p.T256I	LYPD3_uc002owm.2_3'UTR	NM_014400	NP_055215	O95274	LYPD3_HUMAN	GPI-anchored metastasis-associated protein	256						anchored to plasma membrane				pancreas(1)	1		Prostate(69;0.0153)				GGTAGAAGTGGTGACAGATGT	0.612		NA											20	118					0	0	0	0
CACNG7	59284	broad.mit.edu	37	19	54418666	54418666	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr19:54418666G>A	uc002qcr.1	+	3	346	c.331G>A	c.(331-333)GTG>ATG	p.V111M	CACNG7_uc010era.1_Missense_Mutation_p.V111M	NM_031896	NP_114102	P62955	CCG7_HUMAN	voltage-dependent calcium channel gamma-7	111	Helical; (Potential).				regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(1)	1	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0711)		CCTCTTCCTCGTGTTCACGGC	0.607		NA											9	49					0	0	0	0
NLRP8	126205	broad.mit.edu	37	19	56466997	56466997	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr19:56466997C>T	uc002qmh.2	+	3	1644	c.1573C>T	c.(1573-1575)CAA>TAA	p.Q525*	NLRP8_uc010etg.2_Nonsense_Mutation_p.Q525*	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	525	NACHT.					cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		CTGTTTCCCACAAAGACTCAA	0.433		NA											8	171					0	0	0	0
DDX1	1653	broad.mit.edu	37	2	15770222	15770222	+	Missense_Mutation	SNP	A	A	G			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr2:15770222A>G	uc002rce.2	+	25	2368	c.2080A>G	c.(2080-2082)AGG>GGG	p.R694G		NM_004939	NP_004930	Q92499	DDX1_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 1	694	Necessary for interaction with HNRNPK.				DNA duplex unwinding|double-strand break repair|multicellular organismal development|regulation of transcription, DNA-dependent|regulation of translational initiation|spliceosome assembly|transcription, DNA-dependent	cleavage body|stress granule|tRNA-splicing ligase complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|DNA/RNA helicase activity|exonuclease activity|poly(A) RNA binding|protein binding|RNA helicase activity|transcription cofactor activity			central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.197)	all_epithelial(98;2.96e-07)|Acute lymphoblastic leukemia(84;4.24e-05)|Ovarian(717;0.0694)	GBM - Glioblastoma multiforme(3;0.00969)	Epithelial(75;4.35e-05)|OV - Ovarian serous cystadenocarcinoma(76;0.133)		CGGTCAGAAAAGGGCTGCTGG	0.373		NA											3	118					0	0	0	0
APOB	338	broad.mit.edu	37	2	21233487	21233487	+	Nonsense_Mutation	SNP	G	G	A	rs121918386		TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr2:21233487G>A	uc002red.2	-	26	6381	c.6253C>T	c.(6253-6255)CGA>TGA	p.R2085*		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	2085	Heparin-binding.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	ATGGTTTGTCGATTCCTCTCA	0.343		NA											6	57					0	0	0	0
TCF7L1	83439	broad.mit.edu	37	2	85536379	85536379	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr2:85536379G>A	uc002soy.2	+	12	1635	c.1561G>A	c.(1561-1563)GCC>ACC	p.A521T		NM_031283	NP_112573	Q9HCS4	TF7L1_HUMAN	HMG-box transcription factor TCF-3	521					chromatin organization|regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(1)|breast(1)|central_nervous_system(1)	3						CCACTCTGCCGCCTTCCTGTC	0.687		NA											6	26					0	0	0	0
STAT1	6772	broad.mit.edu	37	2	191843715	191843715	+	Silent	SNP	G	G	A			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr2:191843715G>A	uc002usj.2	-	21	2128	c.1740C>T	c.(1738-1740)GGC>GGT	p.G580G	STAT1_uc010fse.1_Silent_p.G580G|STAT1_uc002usk.2_Silent_p.G580G|STAT1_uc002usl.2_Silent_p.G582G	NM_007315	NP_009330	P42224	STAT1_HUMAN	signal transducer and activator of transcription	580	SH2.				activation of caspase activity|I-kappaB kinase/NF-kappaB cascade|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway|tyrosine phosphorylation of STAT protein	cytosol|nucleolus|nucleoplasm	calcium ion binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|signal transducer activity			lung(3)|breast(3)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.00434)|Epithelial(96;0.0555)|all cancers(119;0.141)		Fludarabine(DB01073)	TGCTGATGAAGCCCATGATGC	0.522		NA											3	21					0	0	0	0
PGAP1	80055	broad.mit.edu	37	2	197763049	197763049	+	Silent	SNP	G	G	A			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr2:197763049G>A	uc002utw.2	-	6	966	c.852C>T	c.(850-852)TCC>TCT	p.S284S	PGAP1_uc002utx.2_Silent_p.S110S|PGAP1_uc002uty.1_Silent_p.S284S|PGAP1_uc010zgv.1_RNA|PGAP1_uc010fsj.2_Silent_p.S110S	NM_024989	NP_079265	Q75T13	PGAP1_HUMAN	GPI deacylase	284	Lumenal (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation|intracellular protein transport|myo-inositol transport	integral to membrane|intrinsic to endoplasmic reticulum membrane	nuclease activity|phosphoric ester hydrolase activity			ovary(3)|central_nervous_system(1)	4						ACCACACAATGGAGAGGTGGT	0.343		NA											11	67					0	0	0	0
C20orf54	113278	broad.mit.edu	37	20	746115	746115	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr20:746115C>T	uc002wed.3	-	2	643	c.304G>A	c.(304-306)GGC>AGC	p.G102S	C20orf54_uc002wee.2_Missense_Mutation_p.G102S	NM_033409	NP_212134	Q9NQ40	RFT2_HUMAN	hypothetical protein LOC113278 precursor	102	Helical; (Potential).				sensory perception of sound	integral to plasma membrane	riboflavin transporter activity			ovary(2)	2						CTGTGGTGGCCGTCCAGCACC	0.597		NA											3	10					0	0	0	0
ZNFX1	57169	broad.mit.edu	37	20	47863942	47863942	+	Silent	SNP	C	C	T			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr20:47863942C>T	uc002xui.2	-	14	5866	c.5619G>A	c.(5617-5619)AAG>AAA	p.K1873K		NM_021035	NP_066363	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	1873							metal ion binding			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			CAATCACTTCCTTACAGTCAG	0.527		NA											10	66					0	0	0	0
OLIG2	10215	broad.mit.edu	37	21	34399432	34399432	+	Missense_Mutation	SNP	T	T	G			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr21:34399432T>G	uc002yqx.1	+	2	420	c.262T>G	c.(262-264)TCG>GCG	p.S88A		NM_005806	NP_005797	Q13516	OLIG2_HUMAN	oligodendrocyte lineage transcription factor 2	88	Poly-Ser.					cytoplasm|nucleus|plasma membrane	DNA binding			central_nervous_system(2)	2						GTCTACGTCGTCGGCGGCTGC	0.632		NA	T	TRA@	T-ALL								6	18					0	0	0	0
ZC3H7B	23264	broad.mit.edu	37	22	41752766	41752766	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr22:41752766G>A	uc003azw.2	+	22	2851	c.2635G>A	c.(2635-2637)GGC>AGC	p.G879S	ZC3H7B_uc010gyl.1_Intron	NM_017590	NP_060060	Q9UGR2	Z3H7B_HUMAN	zinc finger CCCH-type containing 7B	895					interspecies interaction between organisms	nucleus	nucleic acid binding|protein binding|zinc ion binding			central_nervous_system(1)	1						TGACGCCAGCGGCTGGGCCTT	0.647		NA											4	115					0	0	0	0
PIK3CA	5290	broad.mit.edu	37	3	178936091	178936091	+	Missense_Mutation	SNP	G	G	A	rs104886003		TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			10	57					0	0	0	0
C4orf37	285555	broad.mit.edu	37	4	98893492	98893492	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr4:98893492G>A	uc003htt.1	-	7	962	c.872C>T	c.(871-873)CCT>CTT	p.P291L		NM_174952	NP_777612	Q8N412	CD037_HUMAN	hypothetical protein LOC285555	291											0				OV - Ovarian serous cystadenocarcinoma(123;2.27e-08)		GAAAGTCCGAGGAACAGAAGA	0.358		NA											6	120					0	0	0	0
METTL14	57721	broad.mit.edu	37	4	119621745	119621745	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr4:119621745C>T	uc003icf.2	+	8	802	c.686C>T	c.(685-687)TCA>TTA	p.S229L	METTL14_uc003icg.2_Missense_Mutation_p.S191L	NM_020961	NP_066012	Q9HCE5	MTL14_HUMAN	methyltransferase like 14	229						nucleus	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity				0						GCACCTCGATCATTTATTTTT	0.338		NA											12	81					0	0	0	0
FAT4	79633	broad.mit.edu	37	4	126372350	126372350	+	Silent	SNP	C	C	T			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr4:126372350C>T	uc003ifj.3	+	9	10179	c.10179C>T	c.(10177-10179)GTC>GTT	p.V3393V	FAT4_uc011cgp.1_Silent_p.V1691V|FAT4_uc003ifi.1_Silent_p.V871V	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	3393	Cadherin 32.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CTGTAAATGTCACCGTGCTTG	0.428		NA											19	161					0	0	0	0
MAP9	79884	broad.mit.edu	37	4	156277012	156277012	+	Silent	SNP	C	C	T			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr4:156277012C>T	uc003ios.2	-	9	1410	c.1146G>A	c.(1144-1146)AAG>AAA	p.K382K	MAP9_uc011cin.1_Silent_p.K357K|MAP9_uc010iqa.1_Intron|MAP9_uc003iot.1_Silent_p.K381K	NM_001039580	NP_001034669	Q49MG5	MAP9_HUMAN	aster-associated protein	382					cell division|mitosis	cytoplasm|microtubule|spindle				ovary(1)|central_nervous_system(1)	2	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.143)		AACTAGATTTCTTCAAAAACT	0.348		NA											4	38					0	0	0	0
ASB5	140458	broad.mit.edu	37	4	177146412	177146412	+	Splice_Site	SNP	C	C	T			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr4:177146412C>T	uc003iuq.1	-	2	292	c.276_splice	c.e2+1	p.Q92_splice	ASB5_uc003iup.1_Splice_Site_p.Q39_splice	NM_080874	NP_543150	Q8WWX0	ASB5_HUMAN	ankyrin repeat and SOCS box-containing protein						intracellular signal transduction					skin(2)	2		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.13e-20)|Epithelial(43;9.94e-18)|OV - Ovarian serous cystadenocarcinoma(60;2e-09)|GBM - Glioblastoma multiforme(59;0.000254)|STAD - Stomach adenocarcinoma(60;0.000653)|LUSC - Lung squamous cell carcinoma(193;0.0393)		TAATATATTACCTGTGATAAT	0.353		NA											5	47					0	0	0	0
C6	729	broad.mit.edu	37	5	41199881	41199881	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr5:41199881C>T	uc003jmk.2	-	4	644	c.434G>A	c.(433-435)CGC>CAC	p.R145H	C6_uc003jml.1_Missense_Mutation_p.R145H	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	145	LDL-receptor class A.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				ACTGTCACAGCGAAATTTATT	0.413		NA											15	105					0	0	0	0
CHD1	1105	broad.mit.edu	37	5	98218909	98218909	+	Silent	SNP	T	T	C			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr5:98218909T>C	uc003knf.2	-	18	2749	c.2601A>G	c.(2599-2601)GGA>GGG	p.G867G		NM_001270	NP_001261	O14646	CHD1_HUMAN	chromodomain helicase DNA binding protein 1	867	Helicase C-terminal.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|methylated histone residue binding			lung(2)|ovary(1)|breast(1)|pancreas(1)	5		all_cancers(142;5.36e-08)|all_epithelial(76;6.97e-11)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|all_lung(232;0.00119)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0717)	Epirubicin(DB00445)	TCCCTAGACCTCCAGCTCTTG	0.373		NA											3	43					0	0	0	0
TMED7-TICAM2	100302736	broad.mit.edu	37	5	114916440	114916440	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr5:114916440G>A	uc003krd.2	-	4	1520	c.514C>T	c.(514-516)CCC>TCC	p.P172S	TMED7-TICAM2_uc003kre.2_Missense_Mutation_p.P341S|TICAM2_uc003krc.2_Missense_Mutation_p.P172S	NM_021649	NP_067681	Q86XR7	TCAM2_HUMAN	toll-like receptor adaptor molecule 2	172	TIR.				I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	Golgi apparatus|intrinsic to membrane|plasma membrane	protein binding|transmembrane receptor activity				0						GGCCGCATGGGTATAACAGAG	0.443		NA											6	84					0	0	0	0
DIAPH1	1729	broad.mit.edu	37	5	140908785	140908785	+	Missense_Mutation	SNP	T	T	C			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr5:140908785T>C	uc003llb.3	-	22	2873	c.2732A>G	c.(2731-2733)AAG>AGG	p.K911R	DIAPH1_uc011dbd.1_5'Flank|DIAPH1_uc003llc.3_Missense_Mutation_p.K902R|DIAPH1_uc010jgc.1_Missense_Mutation_p.K347R	NM_005219	NP_005210	O60610	DIAP1_HUMAN	diaphanous 1 isoform 1	911	FH2.				regulation of microtubule-based process|sensory perception of sound	cytoplasm|cytoskeleton|ruffle membrane	actin binding|receptor binding|Rho GTPase binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATATTCATCCTTCAGTTCAGA	0.498		NA											9	73					0	0	0	0
N4BP3	23138	broad.mit.edu	37	5	177548577	177548577	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr5:177548577C>T	uc003mik.1	+	5	1457	c.1210C>T	c.(1210-1212)CAA>TAA	p.Q404*	N4BP3_uc003mil.1_Nonsense_Mutation_p.Q73*	NM_015111	NP_055926	O15049	N4BP3_HUMAN	Nedd4 binding protein 3	404	Potential.					cytoplasmic vesicle membrane					0	all_cancers(89;0.00294)|Renal(175;0.000269)|Lung NSC(126;0.00858)|all_lung(126;0.0139)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TCTGAAGACACAACTTCGGGG	0.647		NA											13	85					0	0	0	0
MEP1A	4224	broad.mit.edu	37	6	46787388	46787388	+	Nonsense_Mutation	SNP	C	C	G			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr6:46787388C>G	uc010jzh.1	+	7	545	c.503C>G	c.(502-504)TCA>TGA	p.S168*	MEP1A_uc011dwg.1_5'UTR|MEP1A_uc011dwh.1_Nonsense_Mutation_p.S196*|MEP1A_uc011dwi.1_Nonsense_Mutation_p.S68*	NM_005588	NP_005579	Q16819	MEP1A_HUMAN	meprin A alpha precursor	168	Extracellular (Potential).|Metalloprotease.				digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			pancreas(2)|ovary(1)	3			Lung(136;0.192)			CACGAGCAGTCAAGGACGGAC	0.478		NA											5	227					0	0	0	0
PION	54103	broad.mit.edu	37	7	77006706	77006706	+	Missense_Mutation	SNP	A	A	C			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr7:77006706A>C	uc003ugf.2	-	9	657	c.578T>G	c.(577-579)GTG>GGG	p.V193G	PION_uc003ugg.1_5'UTR	NM_017439	NP_059135	A4D1B5	GSAP_HUMAN	pigeon homolog	193					beta-amyloid formation|regulation of proteolysis	trans-Golgi network	beta-amyloid binding			central_nervous_system(1)	1						ATTTTTAATCACCTAAAAATG	0.308		NA											9	64					0	0	0	0
SH2D4A	63898	broad.mit.edu	37	8	19190591	19190591	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr8:19190591C>T	uc003wzb.2	+	3	643	c.307C>T	c.(307-309)CGG>TGG	p.R103W	SH2D4A_uc011kym.1_Missense_Mutation_p.R58W|SH2D4A_uc003wzc.2_Missense_Mutation_p.R103W	NM_022071	NP_071354	Q9H788	SH24A_HUMAN	SH2 domain containing 4A	103						cytoplasm|nucleus	protein binding				0				Colorectal(111;0.0732)		TGAGAGGGCCCGGCTGAAAGC	0.463		NA											8	68					0	0	0	0
CSMD3	114788	broad.mit.edu	37	8	113241099	113241099	+	Nonsense_Mutation	SNP	G	G	T			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr8:113241099G>T	uc003ynu.2	-	70	11009	c.10850C>A	c.(10849-10851)TCA>TAA	p.S3617*	CSMD3_uc003yns.2_Nonsense_Mutation_p.S2819*|CSMD3_uc003ynt.2_Nonsense_Mutation_p.S3577*|CSMD3_uc011lhx.1_Nonsense_Mutation_p.S3448*	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3617	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TGAAGAATTTGAACCTTCTGA	0.279		NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			4	46					0.00909568	0.00988349	1	0
CDKN2A	1029	broad.mit.edu	37	9	21971120	21971120	+	Nonsense_Mutation	SNP	G	G	A	rs121913388		TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr9:21971120G>A	uc003zpk.2	-	2	450	c.238C>T	c.(238-240)CGA>TGA	p.R80*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.P135L	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	80	ANK 3.		R -> P (in CMM2; loss of CDK4 binding).|R -> L (in a head and neck tumor).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.R80*(88)|p.?(13)|p.R80Q(2)|p.P135L(2)|p.T79fs*37(1)|p.L65fs*38(1)|p.R80fs*66(1)|p.A76fs*64(1)|p.T79fs*65(1)|p.E61_L94del(1)|p.A68fs*3(1)|p.R80fs*34(1)|p.R80?(1)|p.R80L(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TGCACGGGTCGGGTGAGAGTG	0.726	R80*(MEWO_SKIN)|R80*(HSC4_UPPER_AERODIGESTIVE_TRACT)	17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			3	14					0	0	0	0
DUSP21	63904	broad.mit.edu	37	X	44703847	44703847	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chrX:44703847G>A	uc004dgd.2	+	1	599	c.469G>A	c.(469-471)GAA>AAA	p.E157K		NM_022076	NP_071359	Q9H596	DUS21_HUMAN	dual specificity phosphatase 21	157	Tyrosine-protein phosphatase.					cytoplasm|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			large_intestine(1)|lung(1)	2						CATCAATTACGAATTCAAGCT	0.498		NA											9	54					0	0	0	0
NUDT11	55190	broad.mit.edu	37	X	51238820	51238820	+	Silent	SNP	C	C	T			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chrX:51238820C>T	uc010njt.2	-	1	640	c.477G>A	c.(475-477)TCG>TCA	p.S159S		NM_018159	NP_060629	Q96G61	NUD11_HUMAN	nudix-type motif 11	159						cytoplasm	diphosphoinositol-polyphosphate diphosphatase activity|metal ion binding				0	Ovarian(276;0.236)					CGCTATCTGGCGAGGATGGGG	0.562		NA								HNSCC(48;0.14)			4	31					0	0	0	0
PCDH11X	27328	broad.mit.edu	37	X	91133558	91133558	+	Missense_Mutation	SNP	T	T	A			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chrX:91133558T>A	uc004efk.1	+	2	3164	c.2319T>A	c.(2317-2319)AAT>AAA	p.N773K	PCDH11X_uc004efl.1_Missense_Mutation_p.N773K|PCDH11X_uc004efo.1_Missense_Mutation_p.N773K|PCDH11X_uc010nmv.1_Missense_Mutation_p.N773K|PCDH11X_uc004efm.1_Missense_Mutation_p.N773K|PCDH11X_uc004efn.1_Missense_Mutation_p.N773K|PCDH11X_uc004efh.1_Missense_Mutation_p.N773K|PCDH11X_uc004efj.1_Missense_Mutation_p.N773K	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	773	Cadherin 7.|Extracellular (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						TGTTCGTGAATGAGTCGGTGA	0.433		NA											15	124					0	0	0	0
SMARCA1	6594	broad.mit.edu	37	X	128615129	128615129	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chrX:128615129G>A	uc004eun.3	-	18	2364	c.2251C>T	c.(2251-2253)CGA>TGA	p.R751*	SMARCA1_uc004eup.3_Nonsense_Mutation_p.R739*|SMARCA1_uc011muk.1_Nonsense_Mutation_p.R751*|SMARCA1_uc011mul.1_Nonsense_Mutation_p.R739*	NM_003069	NP_003060	P28370	SMCA1_HUMAN	SWI/SNF-related matrix-associated	751					ATP-dependent chromatin remodeling|brain development|neuron differentiation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	NURF complex	ATP binding|DNA binding|helicase activity|nucleosome binding|protein binding			ovary(3)|skin(1)	4						TTGCGTTCTCGTTTAGGAGGT	0.423		NA											11	49					0	0	0	0
PNMA3	29944	broad.mit.edu	37	X	152226306	152226306	+	Silent	SNP	A	A	G			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chrX:152226306A>G	uc004fhc.2	+	2	1230	c.894A>G	c.(892-894)TTA>TTG	p.L298L	PNMA5_uc004fha.3_5'Flank|PNMA3_uc004fhd.2_5'Flank	NM_013364	NP_037496	Q9UL41	PNMA3_HUMAN	paraneoplastic cancer-testis-brain antigen	298					apoptosis	nucleolus	nucleic acid binding|zinc ion binding			skin(2)|large_intestine(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					aacgagtcttaagtggggcca	0		NA											6	63					0	0	0	0
F8	2157	broad.mit.edu	37	X	154250784	154250784	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chrX:154250784C>T	uc004fmt.2	-	1	215	c.44G>A	c.(43-45)CGA>CAA	p.R15Q	F8_uc011mzx.1_Intron	NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	15					acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	AAAGCAGAATCGCAAAAGGCA	0.448		NA											4	117					0	0	0	0
CTBS	1486	broad.mit.edu	37	1	85039999	85040007	+	In_Frame_Del	DEL	GCAGCGCCA	GCAGCGCCA	-			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr1:85039999_85040007delGCAGCGCCA	uc001dka.2	-	1	157_165	c.92_100delTGGCGCTGC	c.(91-102)CTGGCGCTGCGG>CGG	p.LAL31del	CTBS_uc001dkc.2_5'UTR|CTBS_uc001dkd.2_5'UTR|CTBS_uc001dkb.2_5'UTR	NM_004388	NP_004379	Q01459	DIAC_HUMAN	chitobiase, di-N-acetyl- precursor	31_33						lysosome	cation binding				0				all cancers(265;0.00727)|Epithelial(280;0.0192)|OV - Ovarian serous cystadenocarcinoma(397;0.166)		GCCGCGAGCCgcagcgccagcagcgccag	0.589		NA											3	6	---	---	---	---	NA	NA	NA	NA
ADCY7	113	broad.mit.edu	37	16	50340985	50340986	+	Frame_Shift_Ins	INS	-	-	C	rs74793314		TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr16:50340985_50340986insC	uc002egd.1	+	14	2045_2046	c.1777_1778insC	c.(1777-1779)GCCfs	p.A593fs	ADCY7_uc002egc.1_Frame_Shift_Ins_p.A593fs	NM_001114	NP_001105	P51828	ADCY7_HUMAN	adenylate cyclase 7	593	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to ethanol|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of cAMP biosynthetic process|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			skin(1)	1		all_cancers(37;0.0127)		GBM - Glioblastoma multiforme(240;0.195)	Bromocriptine(DB01200)	CATCCCCCGGGCCCGCCACGAC	0.658		NA											7	43	---	---	---	---	NA	NA	NA	NA
FAM192A	80011	broad.mit.edu	37	16	57206187	57206189	+	In_Frame_Del	DEL	TTC	TTC	-			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chr16:57206187_57206189delTTC	uc010vhk.1	-	4	581_583	c.322_324delGAA	c.(322-324)GAAdel	p.E108del	FAM192A_uc002ekz.3_In_Frame_Del_p.E108del|FAM192A_uc002ekv.3_In_Frame_Del_p.E31del|FAM192A_uc002ekw.3_In_Frame_Del_p.E108del|FAM192A_uc002ekx.3_In_Frame_Del_p.E108del|FAM192A_uc002eky.3_In_Frame_Del_p.E108del|FAM192A_uc010ccx.2_In_Frame_Del_p.E108del	NM_024946	NP_079222	Q9GZU8	F192A_HUMAN	NEFA-interacting nuclear protein NIP30	108						nucleus					0						GTTCTTTCAGTTCTTCTTCTCTT	0.355		NA											9	108	---	---	---	---	NA	NA	NA	NA
ZNF41	7592	broad.mit.edu	37	X	47308645	47308646	+	Frame_Shift_Ins	INS	-	-	T			TCGA-D6-6515-01A-21D-1870-08	TCGA-D6-6515-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	15c4d640-884c-4d55-897e-2f68314423fe	ab033f13-89a6-427b-8675-eb4228c502a5	g.chrX:47308645_47308646insT	uc004dhs.3	-	4	716_717	c.649_650insA	c.(649-651)ATAfs	p.I217fs	ZNF41_uc004dhu.3_Frame_Shift_Ins_p.I209fs|ZNF41_uc004dht.3_Frame_Shift_Ins_p.I89fs|ZNF41_uc004dhv.3_Frame_Shift_Ins_p.I185fs|ZNF41_uc004dhw.3_Frame_Shift_Ins_p.I177fs|ZNF41_uc004dhy.3_Frame_Shift_Ins_p.I175fs|ZNF41_uc004dhx.3_Frame_Shift_Ins_p.I175fs|ZNF41_uc011mlm.1_Frame_Shift_Ins_p.I89fs	NM_153380	NP_700359	P51814	ZNF41_HUMAN	zinc finger protein 41	217						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3		all_lung(315;0.000129)				CACATGAATTATTTTTTCAATG	0.332		NA											15	131	---	---	---	---	NA	NA	NA	NA