Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
TNFRSF4	7293	broad.mit.edu	37	1	1147457	1147457	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:1147457C>A	uc001ade.2	-	5	504	c.499G>T	c.(499-501)GAG>TAG	p.E167*	TNFRSF4_uc001adf.2_Nonsense_Mutation_p.E171*	NM_003327	NP_003318	P43489	TNR4_HUMAN	tumor necrosis factor receptor superfamily,	167	TNFR-Cys 4.|Extracellular (Potential).				immune response|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|positive regulation of B cell proliferation|positive regulation of immunoglobulin secretion|T cell proliferation	integral to plasma membrane	tumor necrosis factor receptor activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;3.73e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.01e-21)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;4.22e-05)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		TCCCTGTCCTCACAGATTGCG	0.662		NA											6	18					0.00198382	0.00204096	1	0
CCDC27	148870	broad.mit.edu	37	1	3679939	3679939	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:3679939G>A	uc001akv.2	+	7	1303	c.1222G>A	c.(1222-1224)GAG>AAG	p.E408K		NM_152492	NP_689705	Q2M243	CCD27_HUMAN	coiled-coil domain containing 27	408	Glu-rich.									skin(1)	1	all_cancers(77;0.0385)|Ovarian(185;0.0634)|Lung NSC(156;0.21)|all_lung(157;0.218)	all_epithelial(116;5.52e-17)|all_lung(118;1.04e-06)|Lung NSC(185;0.000214)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Lung SC(97;0.0367)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.127)		Epithelial(90;1.11e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.35e-22)|GBM - Glioblastoma multiforme(42;3.46e-16)|Colorectal(212;1.17e-05)|COAD - Colon adenocarcinoma(227;5.76e-05)|Kidney(185;0.00036)|BRCA - Breast invasive adenocarcinoma(365;0.000696)|KIRC - Kidney renal clear cell carcinoma(229;0.00558)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.203)		CGAGTCGTTTGAGGAGGAGCT	0.428		NA											4	26					0	0	0	0
CLSTN1	22883	broad.mit.edu	37	1	9795145	9795145	+	Silent	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:9795145C>G	uc001aqh.2	-	14	2730	c.1971G>C	c.(1969-1971)CTG>CTC	p.L657L	CLSTN1_uc001aqi.2_Silent_p.L647L|CLSTN1_uc010oag.1_Silent_p.L638L|CLSTN1_uc001aqf.2_5'Flank	NM_001009566	NP_001009566	O94985	CSTN1_HUMAN	calsyntenin 1 isoform 1	657	Extracellular (Potential).				homophilic cell adhesion	cell junction|cell projection|endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nucleus|postsynaptic membrane	calcium ion binding			skin(1)	1	all_lung(157;0.222)	all_lung(284;4.03e-05)|Lung NSC(185;6.93e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00314)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|Colorectal(212;8.36e-08)|COAD - Colon adenocarcinoma(227;1.93e-05)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(304;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|STAD - Stomach adenocarcinoma(132;0.00644)|READ - Rectum adenocarcinoma(331;0.0419)		GGACGCCACTCAGGCTGATCT	0.542		NA											29	112					0	0	0	0
TARDBP	23435	broad.mit.edu	37	1	11077026	11077026	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:11077026G>A	uc001art.2	+	3	498	c.364G>A	c.(364-366)GAG>AAG	p.E122K	TARDBP_uc010oap.1_Intron	NM_007375	NP_031401	Q13148	TADBP_HUMAN	TAR DNA binding protein	122	RRM 1.			Missing: Completely abolishes RNA binding.	3'-UTR-mediated mRNA stabilization|cell death|mRNA processing|negative regulation by host of viral transcription|RNA splicing|transcription from RNA polymerase II promoter	nucleus	double-stranded DNA binding|mRNA 3'-UTR binding|nucleotide binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Ovarian(185;0.249)	Lung NSC(185;1.04e-05)|all_lung(284;1.31e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0578)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.37e-07)|COAD - Colon adenocarcinoma(227;7.38e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000299)|Kidney(185;0.000754)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)		GGACCTGAAAGAGTATTTTAG	0.383		NA											21	78					0	0	0	0
C1orf158	93190	broad.mit.edu	37	1	12819396	12819396	+	Missense_Mutation	SNP	G	G	C	rs148059585		TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:12819396G>C	uc001auh.2	+	3	595	c.379G>C	c.(379-381)GAG>CAG	p.E127Q	C1orf158_uc010obe.1_Missense_Mutation_p.E127Q	NM_152290	NP_689503	Q8N1D5	CA158_HUMAN	hypothetical protein LOC93190	127										ovary(1)|central_nervous_system(1)|skin(1)	3	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.06e-06)|COAD - Colon adenocarcinoma(227;0.000273)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00575)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		GTGGCTGCCAGAGAAGTCTGA	0.522		NA											13	50					0	0	0	0
PRAMEF12	390999	broad.mit.edu	37	1	12837643	12837643	+	Silent	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:12837643C>T	uc001aui.2	+	3	1380	c.1353C>T	c.(1351-1353)TTC>TTT	p.F451F		NM_001080830	NP_001074299	O95522	PRA12_HUMAN	PRAME family member 12	451										ovary(3)	3	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00818)|Colorectal(212;5.04e-06)|Kidney(185;4.99e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000198)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TTATTGTGTTCAGCACTGTCC	0.527		NA											25	73					0	0	0	0
AGMAT	79814	broad.mit.edu	37	1	15904338	15904338	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:15904338C>T	uc001awv.1	-	5	885	c.742G>A	c.(742-744)GAA>AAA	p.E248K	DNAJC16_uc001awu.2_Intron	NM_024758	NP_079034	Q9BSE5	SPEB_HUMAN	agmatine ureohydrolase (agmatinase) precursor	248					putrescine biosynthetic process|spermidine biosynthetic process	mitochondrion	agmatinase activity|metal ion binding			skin(1)	1		Breast(348;0.000207)|Colorectal(325;0.000258)|Lung NSC(340;0.000359)|all_lung(284;0.000486)|Renal(390;0.000518)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.93e-07)|COAD - Colon adenocarcinoma(227;3.91e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000121)|KIRC - Kidney renal clear cell carcinoma(229;0.00257)|STAD - Stomach adenocarcinoma(313;0.00734)|READ - Rectum adenocarcinoma(331;0.0649)		CAGCAGTCTTCAGCCAGGACT	0.413		NA											7	19					0	0	0	0
UBR4	23352	broad.mit.edu	37	1	19478158	19478158	+	Missense_Mutation	SNP	C	C	T	rs55848569		TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:19478158C>T	uc001bbi.2	-	48	7196	c.7192G>A	c.(7192-7194)GAT>AAT	p.D2398N	UBR4_uc001bbk.1_Missense_Mutation_p.D52N|UBR4_uc001bbl.1_Missense_Mutation_p.D335N|UBR4_uc001bbm.1_Missense_Mutation_p.D1610N	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	2398					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		AGCTTCTTATCAGCCTGCAGG	0.537		NA											21	54					0	0	0	0
PLA2G2F	64600	broad.mit.edu	37	1	20474786	20474786	+	Silent	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:20474786C>T	uc009vpp.1	+	5	626	c.528C>T	c.(526-528)TTC>TTT	p.F176F		NM_022819	NP_073730	Q9BZM2	PA2GF_HUMAN	phospholipase A2, group IIF	133					lipid catabolic process|phospholipid metabolic process	extracellular region	calcium ion binding|phospholipase A2 activity			ovary(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000247)|Lung NSC(340;0.000285)|Breast(348;0.000812)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|COAD - Colon adenocarcinoma(152;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;8.01e-05)|Kidney(64;0.00017)|GBM - Glioblastoma multiforme(114;0.000524)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.198)		ACCGTGGCTTCCTCAATGTCT	0.582		NA											8	44					0	0	0	0
WNT4	54361	broad.mit.edu	37	1	22456196	22456196	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:22456196C>G	uc001bfs.3	-	2	330	c.226G>C	c.(226-228)GAG>CAG	p.E76Q	WNT4_uc010odt.1_Missense_Mutation_p.E13Q	NM_030761	NP_110388	P56705	WNT4_HUMAN	wingless-type MMTV integration site family,	76					adrenal gland development|androgen biosynthetic process|anterior/posterior pattern formation|axis specification|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway|cellular response to transforming growth factor beta stimulus|dermatome development|endoderm development|epithelial to mesenchymal transition|establishment of protein localization in plasma membrane|female gonad development|female sex determination|liver development|male gonad development|mesonephric tubule development|metanephric mesenchymal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of male gonad development|negative regulation of testicular blood vessel morphogenesis|negative regulation of testosterone biosynthetic process|negative regulation of transcription, DNA-dependent|oocyte development|paramesonephric duct development|positive regulation of aldosterone biosynthetic process|positive regulation of bone mineralization|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of collagen biosynthetic process|positive regulation of cortisol biosynthetic process|positive regulation of osteoblast differentiation|positive regulation of transcription, DNA-dependent|protein palmitoylation|renal vesicle formation|smooth muscle cell differentiation|somatotropin secreting cell differentiation|tertiary branching involved in mammary gland duct morphogenesis|thyroid-stimulating hormone-secreting cell differentiation|Wnt receptor signaling pathway, calcium modulating pathway	cell surface|extracellular space|Golgi apparatus|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|signal transducer activity|transcription corepressor activity			ovary(1)	1		Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;6.55e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;9.02e-26)|Colorectal(126;1.71e-07)|COAD - Colon adenocarcinoma(152;1.17e-05)|GBM - Glioblastoma multiforme(114;2.01e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000568)|KIRC - Kidney renal clear cell carcinoma(1967;0.00277)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.138)		TGGCACTCCTCAATGGCCAGC	0.627		NA											14	40					0	0	0	0
FGR	2268	broad.mit.edu	37	1	27942093	27942093	+	Silent	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:27942093C>T	uc001boj.2	-	7	1016	c.870G>A	c.(868-870)GTG>GTA	p.V290V	FGR_uc001boi.2_5'UTR|FGR_uc001bok.2_Silent_p.V290V|FGR_uc001bol.2_Silent_p.V290V|FGR_uc001bom.2_Silent_p.V290V	NM_005248	NP_005239	P09769	FGR_HUMAN	proto-oncogene tyrosine-protein kinase FGR	290	Protein kinase.				platelet activation|response to virus	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity			skin(2)	2		all_lung(284;2.05e-05)|Colorectal(325;3.46e-05)|Lung NSC(340;3.67e-05)|Renal(390;0.00121)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		TCAGCGTCTTCACCGCCACCT	0.682		NA											8	23					0	0	0	0
PHACTR4	65979	broad.mit.edu	37	1	28793131	28793131	+	Silent	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:28793131C>T	uc001bpw.2	+	6	957	c.675C>T	c.(673-675)GTC>GTT	p.V225V	PHACTR4_uc001bpu.2_Silent_p.V225V|PHACTR4_uc001bpv.1_RNA|PHACTR4_uc001bpx.2_Silent_p.V209V|PHACTR4_uc001bpy.2_Silent_p.V235V	NM_001048183	NP_001041648	Q8IZ21	PHAR4_HUMAN	phosphatase and actin regulator 4 isoform 1	225							actin binding|protein phosphatase inhibitor activity				0		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;7.01e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;1.35e-21)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0144)|READ - Rectum adenocarcinoma(331;0.0649)		ATCTCTCTGTCACCCCTTCCC	0.597		NA											11	36					0	0	0	0
KPNA6	23633	broad.mit.edu	37	1	32632895	32632895	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:32632895C>G	uc001bug.2	+	12	1330	c.1242C>G	c.(1240-1242)ATC>ATG	p.I414M	KPNA6_uc001buh.2_Missense_Mutation_p.I189M|KPNA6_uc010ogx.1_Missense_Mutation_p.I411M|KPNA6_uc010ogy.1_Missense_Mutation_p.I419M|KPNA6_uc009vtz.2_Missense_Mutation_p.I309M	NM_012316	NP_036448	O60684	IMA7_HUMAN	karyopherin alpha 6	414	ARM 9.				NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				CTGAGCAGATCAGGTATTACA	0.473		NA											22	79					0	0	0	0
YARS	8565	broad.mit.edu	37	1	33263435	33263435	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:33263435C>T	uc001bvy.1	-	5	1308	c.520G>A	c.(520-522)GAA>AAA	p.E174K		NM_003680	NP_003671	P54577	SYYC_HUMAN	tyrosyl-tRNA synthetase	174					apoptosis|tyrosyl-tRNA aminoacylation	cytosol|extracellular space|nucleus|soluble fraction	ATP binding|interleukin-8 receptor binding|signal transducer activity|tRNA binding|tyrosine-tRNA ligase activity			skin(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)			L-Tyrosine(DB00135)	AAATACTCTTCATCCAAAGCC	0.274		NA											13	31					0	0	0	0
ZC3H12A	80149	broad.mit.edu	37	1	37941518	37941518	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:37941518G>C	uc001cbb.3	+	2	571	c.421G>C	c.(421-423)GAT>CAT	p.D141H		NM_025079	NP_079355	Q5D1E8	ZC12A_HUMAN	zinc finger CCCH-type containing 12A	141					angiogenesis|apoptosis|cell differentiation	cytoplasm|nucleus|plasma membrane	endonuclease activity|metal ion binding			ovary(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				AGTGGTCATCGATGGGAGCAA	0.592		NA											5	8					0	0	0	0
GNL2	29889	broad.mit.edu	37	1	38040301	38040301	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:38040301C>G	uc001cbk.2	-	11	1430	c.1267G>C	c.(1267-1269)GAG>CAG	p.E423Q		NM_013285	NP_037417	Q13823	NOG2_HUMAN	guanine nucleotide binding protein-like 2	423					ribosome biogenesis	nucleolus	GTP binding|GTPase activity|protein binding			ovary(1)|central_nervous_system(1)	2		Myeloproliferative disorder(586;0.0393)				GCGAGCTTCTCAAGAAAGTCC	0.428		NA											18	28					0	0	0	0
MTF1	4520	broad.mit.edu	37	1	38323027	38323027	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:38323027G>C	uc001cce.1	-	2	445	c.304C>G	c.(304-306)CAG>GAG	p.Q102E	MTF1_uc009vvj.1_Translation_Start_Site	NM_005955	NP_005946	Q14872	MTF1_HUMAN	metal-regulatory transcription factor 1	102						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|zinc ion binding			ovary(1)|pancreas(1)	2	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				AAATGAATCTGATCTGGTGAG	0.453		NA											19	63					0	0	0	0
EBNA1BP2	10969	broad.mit.edu	37	1	43630388	43630388	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:43630388C>T	uc001cin.2	-	8	993	c.796G>A	c.(796-798)GAT>AAT	p.D266N	EBNA1BP2_uc001cio.2_Missense_Mutation_p.D321N|EBNA1BP2_uc001cim.2_Missense_Mutation_p.D161N|EBNA1BP2_uc010ojx.1_Missense_Mutation_p.D321N	NM_006824	NP_006815	Q99848	EBP2_HUMAN	EBNA1 binding protein 2 isoform 2	266					ribosome biogenesis	membrane fraction|nucleolus	protein binding				0	Ovarian(52;0.00579)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GATACATCATCATAGCTCTCC	0.502		NA											13	57					0	0	0	0
PTPRF	5792	broad.mit.edu	37	1	44069508	44069508	+	Silent	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:44069508G>A	uc001cjr.2	+	16	3025	c.2685G>A	c.(2683-2685)AAG>AAA	p.K895K	PTPRF_uc001cjs.2_Silent_p.K886K|PTPRF_uc001cju.2_Intron|PTPRF_uc009vwt.2_Silent_p.K455K|PTPRF_uc001cjv.2_Silent_p.K355K|PTPRF_uc001cjw.2_Silent_p.K121K	NM_002840	NP_002831	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	895	Extracellular (Potential).|Fibronectin type-III 6.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|skin(3)|lung(1)|kidney(1)|central_nervous_system(1)	10	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				TTGCTGCCAAGAACCGGGCTG	0.607		NA											11	26					0	0	0	0
PTPRF	5792	broad.mit.edu	37	1	44069632	44069632	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:44069632G>T	uc001cjr.2	+	16	3149	c.2809G>T	c.(2809-2811)GAC>TAC	p.D937Y	PTPRF_uc001cjs.2_Missense_Mutation_p.D928Y|PTPRF_uc001cju.2_Intron|PTPRF_uc009vwt.2_Missense_Mutation_p.D497Y|PTPRF_uc001cjv.2_Missense_Mutation_p.D397Y|PTPRF_uc001cjw.2_Missense_Mutation_p.D163Y	NM_002840	NP_002831	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	937	Fibronectin type-III 7.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|skin(3)|lung(1)|kidney(1)|central_nervous_system(1)	10	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				ACTGGCCTGGGACCCGCCAGT	0.602		NA											9	21					1.13e-05	1.19e-05	1	0
PTPRF	5792	broad.mit.edu	37	1	44069731	44069731	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:44069731G>C	uc001cjr.2	+	16	3248	c.2908G>C	c.(2908-2910)GAC>CAC	p.D970H	PTPRF_uc001cjs.2_Missense_Mutation_p.D961H|PTPRF_uc001cju.2_Intron|PTPRF_uc009vwt.2_Missense_Mutation_p.D530H|PTPRF_uc001cjv.2_Missense_Mutation_p.D430H|PTPRF_uc001cjw.2_Missense_Mutation_p.D196H	NM_002840	NP_002831	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	970	Fibronectin type-III 7.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|skin(3)|lung(1)|kidney(1)|central_nervous_system(1)	10	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				CATCACGACAGACACCCGCTT	0.597		NA											20	59					0	0	0	0
B4GALT2	8704	broad.mit.edu	37	1	44456097	44456097	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:44456097C>T	uc001clg.2	+	7	1466	c.1096C>T	c.(1096-1098)CCG>TCG	p.P366S	B4GALT2_uc001clh.2_Missense_Mutation_p.P300S|B4GALT2_uc010okl.1_Missense_Mutation_p.P395S|B4GALT2_uc001cli.2_Missense_Mutation_p.P366S|CCDC24_uc001clj.2_5'Flank|CCDC24_uc001clk.2_5'Flank|CCDC24_uc009vxc.2_5'Flank	NM_003780	NP_003771	O60909	B4GT2_HUMAN	UDP-Gal:betaGlcNAc beta 1,4-	366	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity|lactose synthase activity|metal ion binding|N-acetyllactosamine synthase activity			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)			N-Acetyl-D-glucosamine(DB00141)	TGGGCGGCCTCCGTCGTGGCC	0.617		NA											26	99					0	0	0	0
B4GALT2	8704	broad.mit.edu	37	1	44456112	44456112	+	Silent	SNP	C	C	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:44456112C>A	uc001clg.2	+	7	1481	c.1111C>A	c.(1111-1113)CGG>AGG	p.R371R	B4GALT2_uc001clh.2_Silent_p.R305R|B4GALT2_uc010okl.1_Silent_p.R400R|B4GALT2_uc001cli.2_Silent_p.R371R|CCDC24_uc001clj.2_5'Flank|CCDC24_uc001clk.2_5'Flank|CCDC24_uc009vxc.2_5'Flank	NM_003780	NP_003771	O60909	B4GT2_HUMAN	UDP-Gal:betaGlcNAc beta 1,4-	371	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity|lactose synthase activity|metal ion binding|N-acetyllactosamine synthase activity			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)			N-Acetyl-D-glucosamine(DB00141)	GTGGCCCCCTCGGGGCTGACA	0.622		NA											16	81					0.000566183	0.000588851	1	0
LRRC42	115353	broad.mit.edu	37	1	54426051	54426051	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:54426051G>A	uc001cwj.1	+	4	828	c.628G>A	c.(628-630)GAT>AAT	p.D210N	LRRC42_uc001cwl.1_Missense_Mutation_p.D210N|LRRC42_uc001cwk.1_Missense_Mutation_p.D210N|LRRC42_uc009vzm.1_Missense_Mutation_p.D210N	NM_052940	NP_443172	Q9Y546	LRC42_HUMAN	leucine rich repeat containing 42	210	LRR 3.										0						CCACCTGAAGGATAATTGTTT	0.373		NA											32	62					0	0	0	0
HOOK1	51361	broad.mit.edu	37	1	60334000	60334000	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:60334000G>C	uc009wad.2	+	21	2026	c.1924G>C	c.(1924-1926)GAG>CAG	p.E642Q	HOOK1_uc001czo.2_Missense_Mutation_p.E642Q|HOOK1_uc001czp.2_RNA|HOOK1_uc010oor.1_Missense_Mutation_p.E600Q	NM_015888	NP_056972	Q9UJC3	HOOK1_HUMAN	hook homolog 1	642	Potential.				early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|microtubule cytoskeleton organization|multicellular organismal development|protein transport	FHF complex|microtubule	identical protein binding			ovary(1)|breast(1)	2	all_cancers(7;0.000129)					GGCAGAGAAAGAGAGAAGAAT	0.303		NA											11	37					0	0	0	0
KANK4	163782	broad.mit.edu	37	1	62703988	62703988	+	Silent	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:62703988C>T	uc001dah.3	-	10	3326	c.2949G>A	c.(2947-2949)CTG>CTA	p.L983L	KANK4_uc001dai.3_Silent_p.L355L|KANK4_uc001daf.3_Silent_p.L121L|KANK4_uc001dag.3_Silent_p.L339L	NM_181712	NP_859063	Q5T7N3	KANK4_HUMAN	ankyrin repeat domain 38	983	ANK 5.									ovary(3)|skin(2)|lung(1)	6						CGTGGGCTCTCAGAAGCCCAG	0.557		NA											7	29					0	0	0	0
TCTEX1D1	200132	broad.mit.edu	37	1	67236139	67236139	+	Silent	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:67236139G>A	uc001dcv.2	+	3	320	c.189G>A	c.(187-189)CAG>CAA	p.Q63Q	TCTEX1D1_uc009wau.2_RNA|TCTEX1D1_uc009wav.2_RNA	NM_152665	NP_689878	Q8N7M0	TC1D1_HUMAN	Tctex1 domain containing 1	63											0						TTACAGTTCAGATGGAAAACA	0.348		NA											33	105					0	0	0	0
C1orf173	127254	broad.mit.edu	37	1	75055435	75055435	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:75055435C>T	uc001dgg.2	-	12	2275	c.2056G>A	c.(2056-2058)GAG>AAG	p.E686K	uc001dgh.2_Intron|C1orf173_uc001dgi.3_Missense_Mutation_p.E480K	NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	686	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						CCGGACTTCTCAGATAAACCC	0.443		NA											16	102					0	0	0	0
COL24A1	255631	broad.mit.edu	37	1	86289244	86289244	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:86289244C>T	uc001dlj.2	-	45	3806	c.3764G>A	c.(3763-3765)GGA>GAA	p.G1255E	COL24A1_uc001dli.2_Missense_Mutation_p.G391E|COL24A1_uc010osd.1_Missense_Mutation_p.G555E|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	1255	Collagen-like 14.				cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		TCCTTTTAGTCCTTGTTCACC	0.338		NA											21	60					0	0	0	0
CLCA1	1179	broad.mit.edu	37	1	86939133	86939133	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:86939133G>C	uc001dlt.2	+	2	325	c.196G>C	c.(196-198)GAA>CAA	p.E66Q	CLCA1_uc001dls.1_Missense_Mutation_p.E66Q	NM_001285	NP_001276	A8K7I4	CLCA1_HUMAN	chloride channel accessory 1 precursor	66					calcium ion transport	extracellular space|integral to plasma membrane	chloride channel activity			ovary(1)	1		Lung NSC(277;0.239)		all cancers(265;0.0249)|Epithelial(280;0.0476)		GTATCTGCTTGAAGCTACAGG	0.358		NA											7	44					0	0	0	0
GBP3	2635	broad.mit.edu	37	1	89486310	89486310	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:89486310G>C	uc001dmt.2	-	2	300	c.95C>G	c.(94-96)TCT>TGT	p.S32C	GBP3_uc010oss.1_5'UTR|GBP3_uc001dmu.2_5'UTR|GBP3_uc001dmv.2_RNA	NM_018284	NP_060754	Q9H0R5	GBP3_HUMAN	guanylate binding protein 3	32	Helical; (Potential).					integral to membrane	GTP binding|GTPase activity			ovary(1)|pancreas(1)	2		Lung NSC(277;0.123)		all cancers(265;0.0103)|Epithelial(280;0.0293)		TGTAATGGCAGACAGGATTTT	0.517		NA											26	78					0	0	0	0
BCAR3	8412	broad.mit.edu	37	1	94037340	94037340	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:94037340C>T	uc001dpz.2	-	9	2136	c.1861G>A	c.(1861-1863)GAG>AAG	p.E621K	BCAR3_uc001dqa.2_Missense_Mutation_p.E621K|BCAR3_uc001dqb.2_Missense_Mutation_p.E621K|BCAR3_uc001dpx.3_Missense_Mutation_p.E297K|BCAR3_uc001dpy.2_Missense_Mutation_p.E530K|BCAR3_uc009wdm.1_Missense_Mutation_p.E297K	NM_003567	NP_003558	O75815	BCAR3_HUMAN	breast cancer antiestrogen resistance 3	621	Ras-GEF.				response to drug|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)|lung(1)|central_nervous_system(1)	3		all_lung(203;0.00145)|Lung NSC(277;0.00662)		all cancers(265;0.0126)|GBM - Glioblastoma multiforme(16;0.0467)|Epithelial(280;0.166)		GCTCGGTCCTCCAAAGTGCCC	0.557		NA											6	90					0	0	0	0
EXTL2	2135	broad.mit.edu	37	1	101339776	101339776	+	Missense_Mutation	SNP	C	C	T	rs142198700		TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:101339776C>T	uc001dtk.1	-	5	1052	c.715G>A	c.(715-717)GAT>AAT	p.D239N	EXTL2_uc001dtl.1_Missense_Mutation_p.D239N|EXTL2_uc010ouk.1_Missense_Mutation_p.D226N|EXTL2_uc001dtm.1_Missense_Mutation_p.D238N	NM_001439	NP_001430	Q9UBQ6	EXTL2_HUMAN	exostoses-like 2	239	Lumenal (Potential).				N-acetylglucosamine metabolic process|UDP-N-acetylgalactosamine metabolic process	extracellular region|integral to membrane|intrinsic to endoplasmic reticulum membrane	alpha-1,4-N-acetylgalactosaminyltransferase activity|glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|metal ion binding			skin(1)	1		all_epithelial(167;2.48e-06)|all_lung(203;0.000414)|Lung NSC(277;0.000946)		Epithelial(280;0.0425)|all cancers(265;0.0628)|COAD - Colon adenocarcinoma(174;0.148)|Colorectal(144;0.167)|Lung(183;0.195)		TTTTGAGTATCATCTATCAAA	0.383		NA											7	14					0	0	0	0
CSDE1	7812	broad.mit.edu	37	1	115282405	115282405	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:115282405G>T	uc001efk.2	-	3	573	c.107C>A	c.(106-108)TCT>TAT	p.S36Y	CSDE1_uc001efi.2_Missense_Mutation_p.S82Y|CSDE1_uc001efj.2_RNA|CSDE1_uc001efl.2_Missense_Mutation_p.S36Y|CSDE1_uc001efm.2_Missense_Mutation_p.S82Y|CSDE1_uc009wgv.2_Missense_Mutation_p.S36Y|CSDE1_uc001efn.2_Missense_Mutation_p.S36Y	NM_001007553	NP_001007554	O75534	CSDE1_HUMAN	upstream of NRAS isoform 1	36	CSD 1.				male gonad development|regulation of transcription, DNA-dependent	cytoplasm	DNA binding|protein binding|RNA binding			ovary(1)	1	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;2.21e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		AAATCCGTAAGAGGTTAACAG	0.408		NA											97	258					7.48e-49	8.19e-49	1	0
CA14	23632	broad.mit.edu	37	1	150233959	150233959	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:150233959G>A	uc001etx.2	+	3	487	c.178G>A	c.(178-180)GAT>AAT	p.D60N		NM_012113	NP_036245	Q9ULX7	CAH14_HUMAN	carbonic anhydrase XIV precursor	60	Extracellular (Potential).					integral to membrane	carbonate dehydratase activity|metal ion binding			ovary(1)	1	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			ATTTGACCCTGATTTGCCTGC	0.552		NA											14	36					0	0	0	0
SETDB1	9869	broad.mit.edu	37	1	150923439	150923439	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:150923439G>A	uc001evu.2	+	13	2276	c.2086G>A	c.(2086-2088)GAG>AAG	p.E696K	SETDB1_uc009wmf.2_Missense_Mutation_p.E697K|SETDB1_uc001evv.2_Missense_Mutation_p.E696K|SETDB1_uc009wmg.1_Missense_Mutation_p.E696K	NM_001145415	NP_001138887	Q15047	SETB1_HUMAN	SET domain, bifurcated 1 isoform 1	696					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)			CTGTGTCAATGAGATTGACAC	0.468		NA											16	52					0	0	0	0
SNX27	81609	broad.mit.edu	37	1	151630850	151630850	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:151630850C>T	uc001eyn.1	+	3	699	c.683C>T	c.(682-684)TCA>TTA	p.S228L	SNX27_uc001eyo.2_Missense_Mutation_p.S135L|SNX27_uc001eyp.2_Missense_Mutation_p.S42L	NM_030918	NP_112180	Q96L92	SNX27_HUMAN	sorting nexin family member 27	228	PX.				cell communication|protein transport|signal transduction	cytosol|early endosome	phosphatidylinositol binding|protein binding			ovary(2)|central_nervous_system(1)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			TTTTCATTATCAGAACAACAA	0.433		NA											18	124					0	0	0	0
HRNR	388697	broad.mit.edu	37	1	152191644	152191644	+	Missense_Mutation	SNP	C	C	G	rs141963410		TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:152191644C>G	uc001ezt.1	-	3	2537	c.2461G>C	c.(2461-2463)GAG>CAG	p.E821Q		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	821	8				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GAGCCAGACTCGTGTTGCCCA	0.567		NA											11	45					0	0	0	0
S100A2	6273	broad.mit.edu	37	1	153536239	153536239	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:153536239G>C	uc001fcb.2	-	2	450	c.112C>G	c.(112-114)CTG>GTG	p.L38V		NM_005978	NP_005969	P29034	S10A2_HUMAN	S100 calcium binding protein A2	39	EF-hand 1.				endothelial cell migration		calcium ion binding			ovary(1)	1	all_lung(78;5.98e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			TCCTTGTGCAGAAGTTCCTTC	0.582		NA											16	43					0	0	0	0
ADAM15	8751	broad.mit.edu	37	1	155030888	155030888	+	Silent	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:155030888C>T	uc001fgr.1	+	15	1989	c.1888C>T	c.(1888-1890)CTG>TTG	p.L630L	ADAM15_uc001fgq.1_Silent_p.L315L|ADAM15_uc010pet.1_Silent_p.L614L|ADAM15_uc010peu.1_Silent_p.L647L|ADAM15_uc001fgt.1_Silent_p.L630L|ADAM15_uc010pev.1_Silent_p.L640L|ADAM15_uc001fgs.1_Silent_p.L630L|ADAM15_uc001fgu.1_Silent_p.L630L|ADAM15_uc001fgw.1_Silent_p.L630L|ADAM15_uc001fgv.1_Silent_p.L630L|ADAM15_uc001fgx.1_Silent_p.L630L|ADAM15_uc001fgz.1_RNA|ADAM15_uc001fgy.1_RNA|ADAM15_uc001fha.1_RNA|ADAM15_uc001fhb.1_5'UTR	NM_207197	NP_997080	Q13444	ADA15_HUMAN	a disintegrin and metalloproteinase domain 15	630	Extracellular (Potential).|Cys-rich.				angiogenesis|cell-matrix adhesion|collagen catabolic process|proteolysis	acrosomal vesicle|adherens junction|endomembrane system|flagellum|integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			central_nervous_system(3)|skin(2)|ovary(1)	6	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			CCTCCTGACTCTGCCTGGCAC	0.597		NA											8	24					0	0	0	0
CD1E	913	broad.mit.edu	37	1	158324275	158324275	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:158324275C>T	uc001fse.2	+	2	406	c.167C>T	c.(166-168)TCA>TTA	p.S56L	CD1E_uc010pid.1_Missense_Mutation_p.S54L|CD1E_uc010pie.1_Intron|CD1E_uc010pif.1_Intron|CD1E_uc001fsd.2_Missense_Mutation_p.S56L|CD1E_uc001fsk.2_Missense_Mutation_p.S56L|CD1E_uc001fsj.2_Missense_Mutation_p.S56L|CD1E_uc001fsc.2_Intron|CD1E_uc010pig.1_Intron|CD1E_uc001fsa.2_Intron|CD1E_uc001fsf.2_Missense_Mutation_p.S56L|CD1E_uc001fry.2_Missense_Mutation_p.S56L|CD1E_uc001fsg.2_Intron|CD1E_uc001fsh.2_Intron|CD1E_uc001fsi.2_Missense_Mutation_p.S56L|CD1E_uc009wsv.2_Intron|CD1E_uc001frz.2_Missense_Mutation_p.S56L|CD1E_uc009wsw.2_5'Flank	NM_030893	NP_112155	P15812	CD1E_HUMAN	CD1E antigen isoform a precursor	56					antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				skin(3)	3	all_hematologic(112;0.0378)					AGTGAGGGCTCAGGATGGCTG	0.567		NA											19	52					0	0	0	0
SPTA1	6708	broad.mit.edu	37	1	158641186	158641186	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:158641186G>A	uc001fst.1	-	12	1745	c.1546C>T	c.(1546-1548)CAG>TAG	p.Q516*		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	516	Spectrin 6.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					TCATGCTTCTGAAGAAGGGCT	0.488		NA											9	36					0	0	0	0
COPA	1314	broad.mit.edu	37	1	160281696	160281696	+	Silent	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:160281696G>A	uc009wti.2	-	11	1432	c.1038C>T	c.(1036-1038)TTC>TTT	p.F346F	COPA_uc001fvv.3_Silent_p.F346F|COPA_uc009wtj.1_Silent_p.F292F	NM_004371	NP_004362	P53621	COPA_HUMAN	coatomer protein complex, subunit alpha isoform	346					COPI coating of Golgi vesicle|intracellular protein transport|pancreatic juice secretion|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|extracellular space|microsome|soluble fraction	hormone activity|structural molecule activity			ovary(1)|skin(1)	2	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TGGAGCTGTTGAAATCCAGCT	0.473		NA											6	28					0	0	0	0
CD84	8832	broad.mit.edu	37	1	160535406	160535406	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:160535406G>A	uc001fwh.3	-	2	200	c.176C>T	c.(175-177)TCT>TTT	p.S59F	CD84_uc001fwf.3_Missense_Mutation_p.S59F|CD84_uc001fwg.3_Missense_Mutation_p.S59F|CD84_uc009wtn.2_Missense_Mutation_p.S59F|CD84_uc001fwi.3_Intron|CD84_uc001fwj.2_Missense_Mutation_p.S59F|CD84_uc001fwk.2_Missense_Mutation_p.S59F	NM_003874	NP_003865	Q9UIB8	SLAF5_HUMAN	CD84 molecule	59	Extracellular (Potential).				blood coagulation|defense response|homophilic cell adhesion|leukocyte migration	integral to plasma membrane	receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(52;3.62e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			ATAAGCAACAGATGTTTTAGA	0.423		NA											36	111					0	0	0	0
C1orf156	92342	broad.mit.edu	37	1	169761757	169761757	+	Silent	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:169761757C>T	uc001ggn.2	-	2	1358	c.1080G>A	c.(1078-1080)AAG>AAA	p.K360K	C1orf112_uc001ggj.2_Intron|C1orf112_uc001ggo.2_5'Flank|uc010plt.1_5'Flank|C1orf112_uc001ggp.2_5'Flank|C1orf112_uc001ggq.2_5'Flank	NM_033418	NP_219486	O95568	MET18_HUMAN	hypothetical protein MGC9084	360						cytoplasm	protein methyltransferase activity				0	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TTATGAACCTCTTCAATCCTT	0.308		NA											3	8					0	0	0	0
TNR	7143	broad.mit.edu	37	1	175299264	175299264	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:175299264C>A	uc001gkp.1	-	19	3820	c.3739G>T	c.(3739-3741)GAG>TAG	p.E1247*	TNR_uc009wwu.1_Nonsense_Mutation_p.E1247*	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	1247	Fibrinogen C-terminal.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					CTGCTGTCCTCGACAGAGAAC	0.587		NA											13	32					4.38e-07	4.68e-07	1	0
FAM20B	9917	broad.mit.edu	37	1	179041145	179041145	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:179041145G>A	uc001gmc.2	+	8	1389	c.1096G>A	c.(1096-1098)GTG>ATG	p.V366M		NM_014864	NP_055679	O75063	XYLK_HUMAN	hypothetical protein LOC9917 precursor	366	Lumenal (Potential).					Golgi membrane|integral to membrane	ATP binding|kinase activity|phosphotransferase activity, alcohol group as acceptor			ovary(3)	3						CATCTCCCCAGTGCTCTCTGA	0.557		NA											35	89					0	0	0	0
TMCC2	9911	broad.mit.edu	37	1	205238423	205238423	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:205238423G>C	uc001hbz.1	+	4	1537	c.1093G>C	c.(1093-1095)GAG>CAG	p.E365Q	TMCC2_uc010prf.1_Missense_Mutation_p.E287Q|TMCC2_uc001hca.2_Missense_Mutation_p.E140Q|TMCC2_uc001hcb.1_Missense_Mutation_p.E125Q|TMCC2_uc001hcc.1_5'UTR|TMCC2_uc001hcd.2_Missense_Mutation_p.E132Q	NM_014858	NP_055673	O75069	TMCC2_HUMAN	transmembrane and coiled-coil domain family 2	365	Potential.					integral to membrane	protein binding			pancreas(1)	1	Breast(84;0.0871)		BRCA - Breast invasive adenocarcinoma(75;0.117)			GAAGGAGATTGAGCAGAACGG	0.632		NA											9	9					0	0	0	0
CR2	1380	broad.mit.edu	37	1	207643212	207643212	+	Silent	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:207643212G>A	uc001hfw.2	+	6	1084	c.990G>A	c.(988-990)CAG>CAA	p.Q330Q	CR2_uc001hfv.2_Silent_p.Q330Q|CR2_uc009xch.2_Silent_p.Q330Q|CR2_uc009xci.1_5'Flank	NM_001877	NP_001868	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus)	330	Sushi 5.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			upper_aerodigestive_tract(3)|skin(3)|urinary_tract(1)|ovary(1)	8						TTGATAGTCAGAAGACTGGGA	0.517		NA											10	25					0	0	0	0
SERTAD4	56256	broad.mit.edu	37	1	210415084	210415084	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:210415084G>A	uc001hhy.2	+	4	652	c.473G>A	c.(472-474)GGC>GAC	p.G158D	SERTAD4_uc009xcw.2_Missense_Mutation_p.G158D	NM_019605	NP_062551	Q9NUC0	SRTD4_HUMAN	SERTA domain containing 4	158							protein binding			ovary(1)|pancreas(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0237)|all cancers(67;0.127)		TCTTTCAATGGCACCTCTGCC	0.453		NA											42	97					0	0	0	0
KCNK2	3776	broad.mit.edu	37	1	215368397	215368397	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:215368397G>A	uc001hkq.2	+	6	1094	c.925G>A	c.(925-927)GAT>AAT	p.D309N	KCNK2_uc001hko.2_Missense_Mutation_p.D305N|KCNK2_uc009xdm.2_RNA|KCNK2_uc001hkp.2_RNA|KCNK2_uc010pua.1_RNA|KCNK2_uc001hkr.3_Missense_Mutation_p.D294N	NM_001017425	NP_001017425	O95069	KCNK2_HUMAN	potassium channel, subfamily K, member 2 isoform	309	Cytoplasmic (Potential).			DWL -> RLV (in Ref. 3; AAD01203).			outward rectifier potassium channel activity				0				OV - Ovarian serous cystadenocarcinoma(81;0.0399)|all cancers(67;0.0556)|GBM - Glioblastoma multiforme(131;0.068)	Dofetilide(DB00204)	CATGATTGGAGATTGGCTCCG	0.373		NA											46	134					0	0	0	0
ZNF678	339500	broad.mit.edu	37	1	227842557	227842557	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:227842557T>G	uc001hqw.1	+	4	951	c.606T>G	c.(604-606)ATT>ATG	p.I202M	ZNF678_uc009xet.1_Intron|ZNF678_uc009xeu.1_Intron	NM_178549	NP_848644	F5GXA7	F5GXA7_HUMAN	zinc finger protein 678	257					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			pancreas(1)	1		Prostate(94;0.0885)				ATAAGAAAATTCATAGTGGAG	0.368		NA											39	116					0	0	0	0
GTPBP4	23560	broad.mit.edu	37	10	1063059	1063059	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr10:1063059G>C	uc001ift.2	+	17	1868	c.1797G>C	c.(1795-1797)AAG>AAC	p.K599N	GTPBP4_uc001ifu.2_RNA|GTPBP4_uc010qad.1_Missense_Mutation_p.K483N|GTPBP4_uc010qae.1_Missense_Mutation_p.K552N	NM_012341	NP_036473	Q9BZE4	NOG1_HUMAN	G protein-binding protein CRFG	599					negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of cell-cell adhesion|negative regulation of collagen binding|negative regulation of DNA replication|negative regulation of protein ubiquitination|protein stabilization|regulation of cyclin-dependent protein kinase activity|ribosome biogenesis	nucleolus|perinuclear region of cytoplasm	GTP binding|GTPase activity|protein binding			ovary(1)|skin(1)	2		all_epithelial(10;0.107)|Colorectal(49;0.14)	OV - Ovarian serous cystadenocarcinoma(33;0.0814)	Epithelial(11;0.0513)|all cancers(11;0.135)|OV - Ovarian serous cystadenocarcinoma(14;0.173)		CTCAGAAGAAGATGAATCGGT	0.403		NA											15	63					0	0	0	0
WDR37	22884	broad.mit.edu	37	10	1123898	1123898	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr10:1123898C>G	uc001igf.1	+	3	363	c.190C>G	c.(190-192)CAA>GAA	p.Q64E	WDR37_uc001ige.2_Missense_Mutation_p.Q64E|WDR37_uc009xhm.1_Missense_Mutation_p.Q64E|WDR37_uc009xhn.1_Intron|WDR37_uc001igg.1_RNA	NM_014023	NP_054742	Q9Y2I8	WDR37_HUMAN	WD repeat domain 37	64											0		all_epithelial(10;0.0449)|Colorectal(49;0.142)		Epithelial(11;0.134)		ACTGTTTGGTCAAATAGAAAG	0.318		NA											19	63					0	0	0	0
DHTKD1	55526	broad.mit.edu	37	10	12126746	12126746	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr10:12126746C>G	uc001ild.3	+	3	617	c.518C>G	c.(517-519)TCT>TGT	p.S173C		NM_018706	NP_061176	Q96HY7	DHTK1_HUMAN	dehydrogenase E1 and transketolase domain	173					glycolysis	mitochondrion	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			ovary(1)|central_nervous_system(1)	2		Renal(717;0.228)	BRCA - Breast invasive adenocarcinoma(52;0.188)			ATGCTGGAATCTCAGGTAAAA	0.269		NA											12	54					0	0	0	0
JMJD1C	221037	broad.mit.edu	37	10	64946111	64946111	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr10:64946111C>T	uc001jmn.2	-	19	6903	c.6603G>A	c.(6601-6603)ATG>ATA	p.M2201I	JMJD1C_uc001jml.2_Missense_Mutation_p.M1964I|JMJD1C_uc001jmm.2_Missense_Mutation_p.M1913I|JMJD1C_uc010qiq.1_Missense_Mutation_p.M2019I|JMJD1C_uc009xpi.2_Missense_Mutation_p.M2019I|JMJD1C_uc009xpj.1_RNA|JMJD1C_uc001jmo.2_Missense_Mutation_p.M108I	NM_032776	NP_116165	Q15652	JHD2C_HUMAN	jumonji domain containing 1C isoform a	2201					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			ovary(4)|breast(1)|central_nervous_system(1)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)					GGCTAATGTTCATTTTCTTAT	0.318		NA											8	32					0	0	0	0
MYPN	84665	broad.mit.edu	37	10	69881415	69881415	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr10:69881415G>A	uc001jnm.3	+	3	405	c.220G>A	c.(220-222)GAA>AAA	p.E74K	MYPN_uc001jnl.1_Missense_Mutation_p.E74K|MYPN_uc001jnn.3_Intron|MYPN_uc001jno.3_Missense_Mutation_p.E74K|MYPN_uc001jnp.1_Missense_Mutation_p.E74K|MYPN_uc009xps.2_Missense_Mutation_p.E74K|MYPN_uc009xpt.2_Missense_Mutation_p.E74K|MYPN_uc010qit.1_5'UTR|MYPN_uc010qiu.1_RNA	NM_032578	NP_115967	Q86TC9	MYPN_HUMAN	myopalladin	74	Interaction with CARP.					nucleus|sarcomere	actin binding			ovary(3)|skin(2)	5						AGAATTAGACGAAAGTGTCAA	0.488		NA											12	50					0	0	0	0
RUFY2	55680	broad.mit.edu	37	10	70156607	70156607	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr10:70156607G>A	uc001job.2	-	4	760	c.433C>T	c.(433-435)CGA>TGA	p.R145*	RUFY2_uc001jnz.1_RNA|RUFY2_uc001joc.2_Intron|RUFY2_uc010qiw.1_Nonsense_Mutation_p.R52*|RUFY2_uc001jod.1_Nonsense_Mutation_p.R110*|RUFY2_uc009xpv.1_5'UTR|RUFY2_uc001joe.1_Nonsense_Mutation_p.R110*	NM_017987	NP_060457	Q8WXA3	RUFY2_HUMAN	RUN and FYVE domain-containing 2 isoform a	159	RUN.					nucleus	metal ion binding			ovary(1)	1						AGGGCTAATCGAAGCCACGCT	0.428		NA											17	38					0	0	0	0
SUPV3L1	6832	broad.mit.edu	37	10	70958267	70958267	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr10:70958267G>A	uc001jpe.1	+	9	1218	c.1163G>A	c.(1162-1164)CGG>CAG	p.R388Q	SUPV3L1_uc010qjd.1_Missense_Mutation_p.R257Q	NM_003171	NP_003162	Q8IYB8	SUV3_HUMAN	suppressor of var1, 3-like 1 precursor	388	Helicase C-terminal.				DNA duplex unwinding	mitochondrial nucleoid|nucleus	ATP binding|DNA binding|DNA helicase activity|RNA binding			urinary_tract(1)|ovary(1)	2						ATTGAAATTCGGGGATTAGAA	0.393		NA											21	84					0	0	0	0
TTC18	118491	broad.mit.edu	37	10	75051064	75051064	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr10:75051064C>G	uc009xrc.2	-	20	2490	c.2369G>C	c.(2368-2370)AGA>ACA	p.R790T	TTC18_uc001jty.2_Missense_Mutation_p.R790T|TTC18_uc001jtv.3_Intron|TTC18_uc001jtw.3_Intron|TTC18_uc001jtx.2_Missense_Mutation_p.R171T	NM_145170	NP_660153	Q5T0N1	TTC18_HUMAN	tetratricopeptide repeat domain 18	790							binding			ovary(2)|central_nervous_system(1)	3	Prostate(51;0.0119)					TCTCTTCCCTCTTTCCTCAGT	0.493		NA											23	121					0	0	0	0
VCL	7414	broad.mit.edu	37	10	75877857	75877857	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr10:75877857C>T	uc001jwd.2	+	22	3429	c.3335C>T	c.(3334-3336)GCT>GTT	p.A1112V	VCL_uc009xrr.2_Missense_Mutation_p.A793V|VCL_uc001jwe.2_Missense_Mutation_p.A1044V|VCL_uc010qkz.1_Missense_Mutation_p.A305V	NM_014000	NP_054706	P18206	VINC_HUMAN	vinculin isoform meta-VCL	1112	C-terminal tail.				adherens junction assembly|apical junction assembly|cell-matrix adhesion|cellular component movement|epithelial cell-cell adhesion|lamellipodium assembly|morphogenesis of an epithelium|muscle contraction|negative regulation of cell migration|platelet activation|platelet degranulation|protein localization at cell surface	costamere|cytosol|extracellular region|focal adhesion	actin binding|alpha-catenin binding|beta-catenin binding|beta-dystroglycan binding|cadherin binding|structural molecule activity		VCL/ALK(4)	kidney(4)|ovary(1)|central_nervous_system(1)	6	Prostate(51;0.0112)					GCTGAAGCTGCTTCAATCAAA	0.517		NA											4	69					0	0	0	0
HECTD2	143279	broad.mit.edu	37	10	93242780	93242780	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr10:93242780G>C	uc001khl.2	+	8	868	c.768G>C	c.(766-768)CAG>CAC	p.Q256H	LOC100188947_uc010qnl.1_Intron|HECTD2_uc010qnm.1_Missense_Mutation_p.Q256H|HECTD2_uc001khm.2_RNA|HECTD2_uc009xty.1_5'UTR|HECTD2_uc001khn.1_5'Flank	NM_182765	NP_877497	Q5U5R9	HECD2_HUMAN	HECT domain containing 2 isoform a	256					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			skin(1)	1						TGCTACGACAGATAGCTACCT	0.308		NA											16	35					0	0	0	0
CYP2C9	1559	broad.mit.edu	37	10	96702031	96702031	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr10:96702031G>C	uc001kka.3	+	3	439	c.414G>C	c.(412-414)AAG>AAC	p.K138N	CYP2C9_uc009xut.2_Missense_Mutation_p.K138N|CYP2C9_uc001kjz.2_Missense_Mutation_p.K138N	NM_000771	NP_000762	P11712	CP2C9_HUMAN	cytochrome P450, family 2, subfamily C,	138					exogenous drug catabolic process|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid metabolic process|urea metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|caffeine oxidase activity|drug binding|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			skin(4)|ovary(2)	6		Colorectal(252;0.0902)		all cancers(201;6.93e-05)	Acenocoumarol(DB01418)|Alosetron(DB00969)|Amiodarone(DB01118)|Antihemophilic Factor(DB00025)|Aprepitant(DB00673)|Bosentan(DB00559)|Carprofen(DB00821)|Carvedilol(DB01136)|Celecoxib(DB00482)|Clomipramine(DB01242)|Dapsone(DB00250)|Delavirdine(DB00705)|Desloratadine(DB00967)|Desogestrel(DB00304)|Diclofenac(DB00586)|Esomeprazole(DB00736)|Etodolac(DB00749)|Fluconazole(DB00196)|Fluoxetine(DB00472)|Flurbiprofen(DB00712)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Gemfibrozil(DB01241)|Ginkgo biloba(DB01381)|Glibenclamide(DB01016)|Glimepiride(DB00222)|Glipizide(DB01067)|Guanfacine(DB01018)|Hydromorphone(DB00327)|Ibuprofen(DB01050)|Imipramine(DB00458)|Irbesartan(DB01029)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Losartan(DB00678)|Lumiracoxib(DB01283)|Marinol(DB00470)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mephenytoin(DB00532)|Metronidazole(DB00916)|Miconazole(DB01110)|Midazolam(DB00683)|Montelukast(DB00471)|Nateglinide(DB00731)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Oxymorphone(DB01192)|Pantoprazole(DB00213)|Paramethadione(DB00617)|Phenprocoumon(DB00946)|Phenytoin(DB00252)|Pravastatin(DB00175)|Quinidine(DB00908)|Ritonavir(DB00503)|Rosiglitazone(DB00412)|Sertraline(DB01104)|Sildenafil(DB00203)|Sulfamethoxazole(DB01015)|Suprofen(DB00870)|Tamoxifen(DB00675)|Tenoxicam(DB00469)|Terfenadine(DB00342)|Tolbutamide(DB01124)|Torasemide(DB00214)|Troleandomycin(DB01361)|Valdecoxib(DB00580)|Valsartan(DB00177)|Voriconazole(DB00582)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zileuton(DB00744)	GGATGGGGAAGAGGAGCATTG	0.502		NA											16	68					0	0	0	0
SFRP5	6425	broad.mit.edu	37	10	99527298	99527298	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr10:99527298G>T	uc001kor.3	-	3	1093	c.927C>A	c.(925-927)TTC>TTA	p.F309L		NM_003015	NP_003006	Q5T4F7	SFRP5_HUMAN	secreted frizzled-related protein 5 precursor	309					apoptosis|brain development|cell differentiation|embryo development|establishment or maintenance of cell polarity|gonad development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of cell proliferation|negative regulation of protein kinase B signaling cascade|negative regulation of sequence-specific DNA binding transcription factor activity|vasculature development|visual perception	cytoplasm|extracellular space|plasma membrane	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(1)	1		Colorectal(252;0.234)		Epithelial(162;4.98e-10)|all cancers(201;3.58e-08)		CCCCGTAGAAGAAAGGGTAGT	0.587		NA											5	21					0.00116845	0.00120535	1	0
SFRP5	6425	broad.mit.edu	37	10	99527328	99527328	+	Silent	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr10:99527328G>A	uc001kor.3	-	3	1063	c.897C>T	c.(895-897)TTC>TTT	p.F299F		NM_003015	NP_003006	Q5T4F7	SFRP5_HUMAN	secreted frizzled-related protein 5 precursor	299	NTR.				apoptosis|brain development|cell differentiation|embryo development|establishment or maintenance of cell polarity|gonad development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of cell proliferation|negative regulation of protein kinase B signaling cascade|negative regulation of sequence-specific DNA binding transcription factor activity|vasculature development|visual perception	cytoplasm|extracellular space|plasma membrane	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(1)	1		Colorectal(252;0.234)		Epithelial(162;4.98e-10)|all cancers(201;3.58e-08)		AGGGGTAGGAGAACATGAATT	0.567		NA											8	29					0	0	0	0
CWF19L1	55280	broad.mit.edu	37	10	102003530	102003530	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr10:102003530C>A	uc001kqq.1	-	10	1056	c.969G>T	c.(967-969)CAG>CAT	p.Q323H	CWF19L1_uc001kqs.1_Missense_Mutation_p.Q75H|CWF19L1_uc001kqr.1_Missense_Mutation_p.Q323H|CWF19L1_uc001kqt.1_Splice_Site_p.P28_splice|CWF19L1_uc010qpn.1_Missense_Mutation_p.Q186H	NM_018294	NP_060764	Q69YN2	C19L1_HUMAN	CWF19-like 1, cell cycle control	323							catalytic activity				0		Colorectal(252;0.117)		Epithelial(162;3.78e-10)|all cancers(201;3.1e-08)		GTCCTGGAGGCTGAGCTTCAT	0.443		NA											29	90					1.89e-17	2.06e-17	1	0
PSD	5662	broad.mit.edu	37	10	104173810	104173810	+	Silent	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr10:104173810G>A	uc001kvg.1	-	5	1796	c.1269C>T	c.(1267-1269)CTC>CTT	p.L423L	PSD_uc001kvh.1_Silent_p.L44L|PSD_uc009xxd.1_Silent_p.L423L	NM_002779	NP_002770	A5PKW4	PSD1_HUMAN	pleckstrin and Sec7 domain containing	423					regulation of ARF protein signal transduction	cytoplasm|plasma membrane|ruffle	ARF guanyl-nucleotide exchange factor activity|signal transducer activity			breast(2)|urinary_tract(1)	3				Epithelial(162;1.27e-08)|all cancers(201;2.85e-07)		CCAGCGAGGCGAGGCTGGTAT	0.652		NA											4	46					0	0	0	0
MUC6	4588	broad.mit.edu	37	11	1016425	1016425	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:1016425G>A	uc001lsw.2	-	31	6427	c.6376C>T	c.(6376-6378)CAG>TAG	p.Q2126*		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	mucin 6, gastric	2126	Ser-rich.|Thr-rich.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GAGGACAGCTGATTAGTTGTG	0.527		NA											5	26					0	0	0	0
RRP8	23378	broad.mit.edu	37	11	6622653	6622653	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:6622653C>T	uc001med.2	-	3	722	c.643G>A	c.(643-645)GCC>ACC	p.A215T	ILK_uc001mee.2_5'Flank|ILK_uc001mef.2_5'Flank|ILK_uc010rap.1_5'Flank|ILK_uc010raq.1_5'Flank|ILK_uc001meg.2_5'Flank|ILK_uc001meh.2_5'Flank	NM_015324	NP_056139	O43159	RRP8_HUMAN	ribosomal RNA processing 8, methyltransferase,	215					chromatin modification|chromatin silencing at rDNA|rRNA processing|transcription, DNA-dependent	chromatin silencing complex|nucleolus|rDNA heterochromatin	methylated histone residue binding|S-adenosylmethionine-dependent methyltransferase activity				0						TCTGTGGGGGCCTCAGCTGGG	0.592		NA											11	39					0	0	0	0
DKK3	27122	broad.mit.edu	37	11	11988594	11988594	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:11988594G>A	uc001mju.2	-	5	637	c.580C>T	c.(580-582)CAC>TAC	p.H194Y	DKK3_uc010rcf.1_Missense_Mutation_p.H166Y|DKK3_uc001mjv.2_Missense_Mutation_p.H194Y|DKK3_uc001mjw.2_Missense_Mutation_p.H194Y|DKK3_uc010rcg.1_Missense_Mutation_p.H194Y	NM_001018057	NP_001018067	Q9UBP4	DKK3_HUMAN	dickkopf homolog 3 precursor	194	DKK-type Cys-1.				adrenal gland development|anatomical structure morphogenesis|negative regulation of aldosterone biosynthetic process|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cortisol biosynthetic process|negative regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	extracellular space				breast(1)	1				Epithelial(150;0.000502)		TTGGTGCAGTGACCCCAGACA	0.622		NA									OREG0020766	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	41					0	0	0	0
C11orf58	10944	broad.mit.edu	37	11	16760339	16760339	+	Missense_Mutation	SNP	G	G	C	rs146011841		TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:16760339G>C	uc001mmk.2	+	1	192	c.14G>C	c.(13-15)AGA>ACA	p.R5T	C11orf58_uc010rct.1_5'UTR|SOX6_uc001mmh.1_5'Flank	NM_014267	NP_055082	O00193	SMAP_HUMAN	small acidic protein isoform a	5											0						AGTGCTGCCAGAGAGTCTCAC	0.582		NA											3	46					0	0	0	0
WT1	7490	broad.mit.edu	37	11	32417879	32417879	+	Silent	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:32417879G>A	uc001mtn.1	-	7	1369	c.1173C>T	c.(1171-1173)TTC>TTT	p.F391F	WT1_uc001mtl.1_Silent_p.F179F|WT1_uc001mtm.1_Silent_p.F162F|WT1_uc001mto.1_Silent_p.F391F|WT1_uc001mtp.1_Silent_p.F374F|WT1_uc001mtq.1_Silent_p.F374F|WT1_uc009yjs.1_RNA	NM_024426	NP_077744	P19544	WT1_HUMAN	Wilms tumor 1 isoform D	323	C2H2-type 1.				adrenal cortex formation|branching involved in ureteric bud morphogenesis|camera-type eye development|cardiac muscle cell fate commitment|cellular response to cAMP|cellular response to gonadotropin stimulus|germ cell development|glomerular basement membrane development|glomerular visceral epithelial cell differentiation|induction of apoptosis|male genitalia development|male gonad development|mesenchymal to epithelial transition|metanephric epithelium development|metanephric S-shaped body morphogenesis|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of female gonad development|negative regulation of metanephric glomerular mesangial cell proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of translation|positive regulation of male gonad development|positive regulation of transcription, DNA-dependent|posterior mesonephric tubule development|regulation of organ formation|RNA splicing|sex determination|vasculogenesis|visceral serous pericardium development	cytoplasm|nuclear speck|nucleoplasm	C2H2 zinc finger domain binding|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding	p.V380_S410del(1)	EWSR1/WT1(231)	haematopoietic_and_lymphoid_tissue(318)|soft_tissue(231)|kidney(132)|pleura(2)|lung(2)|upper_aerodigestive_tract(1)|peritoneum(1)	687	Breast(20;0.247)		OV - Ovarian serous cystadenocarcinoma(30;0.128)			AAGCACACATGAAGGGGCGTT	0.542		NA	D|Mis|N|F|S	EWSR1	Wilms|desmoplastic small round cell tumor	Wilms			Denys-Drash_syndrome|Frasier_syndrome|Familial_Wilms_tumor|Wilms_tumor-Aniridia-ambiguous_Genitals-mental_Retardation				17	49					0	0	0	0
C11orf41	25758	broad.mit.edu	37	11	33689480	33689480	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:33689480C>G	uc001mup.3	+	20	5472	c.5348C>G	c.(5347-5349)TCC>TGC	p.S1783C		NM_012194	NP_036326	Q6ZVL6	CK041_HUMAN	hypothetical protein LOC25758	1777						integral to membrane				ovary(2)	2						AGCTCTCCCTCCAGGCTTCCT	0.687		NA											7	12					0	0	0	0
AHNAK	79026	broad.mit.edu	37	11	62286412	62286412	+	Silent	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:62286412C>G	uc001ntl.2	-	5	15777	c.15477G>C	c.(15475-15477)CTG>CTC	p.L5159L	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	5159					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TGGGGCCTTTCAGGTCACCCT	0.522		NA											9	44					0	0	0	0
AHNAK	79026	broad.mit.edu	37	11	62291157	62291157	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:62291157C>T	uc001ntl.2	-	5	11032	c.10732G>A	c.(10732-10734)GAT>AAT	p.D3578N	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	3578					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				CCTTTGATATCAACCTCTGGC	0.468		NA											55	162					0	0	0	0
AHNAK	79026	broad.mit.edu	37	11	62294428	62294428	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:62294428C>G	uc001ntl.2	-	5	7761	c.7461G>C	c.(7459-7461)ATG>ATC	p.M2487I	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	2487					nervous system development	nucleus	protein binding	p.M2487V(1)		ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				CCCTGATGTTCATATCTGGTA	0.478		NA											49	147					0	0	0	0
AHNAK	79026	broad.mit.edu	37	11	62296791	62296791	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:62296791C>G	uc001ntl.2	-	5	5398	c.5098G>C	c.(5098-5100)GAT>CAT	p.D1700H	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	1700					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				ACCTCCACATCTGGGGCATCA	0.493		NA											60	241					0	0	0	0
AHNAK	79026	broad.mit.edu	37	11	62296833	62296833	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:62296833C>G	uc001ntl.2	-	5	5356	c.5056G>C	c.(5056-5058)GAT>CAT	p.D1686H	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	1686					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				ATGTCAACATCTGGCACTTTC	0.488		NA											71	259					0	0	0	0
AHNAK	79026	broad.mit.edu	37	11	62297749	62297749	+	Silent	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:62297749C>T	uc001ntl.2	-	5	4440	c.4140G>A	c.(4138-4140)CTG>CTA	p.L1380L	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	1380					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TGGGCATCTTCAGGTGCCAAT	0.498		NA											81	236					0	0	0	0
AHNAK	79026	broad.mit.edu	37	11	62298201	62298201	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:62298201C>G	uc001ntl.2	-	5	3988	c.3688G>C	c.(3688-3690)GAA>CAA	p.E1230Q	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	1230					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				CCTTTGATTTCAACATCTGGC	0.483		NA											89	285					0	0	0	0
AHNAK	79026	broad.mit.edu	37	11	62298786	62298786	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:62298786C>G	uc001ntl.2	-	5	3403	c.3103G>C	c.(3103-3105)GAT>CAT	p.D1035H	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	1035					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				GCATTAGTATCTACTTTTGGT	0.463		NA											14	84					0	0	0	0
SF1	7536	broad.mit.edu	37	11	64536578	64536578	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:64536578G>C	uc001obb.1	-	8	1180	c.803C>G	c.(802-804)TCA>TGA	p.S268*	SF1_uc010rnm.1_5'UTR|SF1_uc010rnn.1_Nonsense_Mutation_p.S242*|SF1_uc001oaz.1_Nonsense_Mutation_p.S393*|SF1_uc001oba.1_Nonsense_Mutation_p.S268*|SF1_uc001obc.1_Nonsense_Mutation_p.S268*|SF1_uc001obd.1_Nonsense_Mutation_p.S268*|SF1_uc001obe.1_Nonsense_Mutation_p.S153*|SF1_uc010rno.1_Nonsense_Mutation_p.S153*	NM_004630	NP_004621	Q15637	SF01_HUMAN	splicing factor 1 isoform 1	268					nuclear mRNA 3'-splice site recognition|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ribosome|spliceosomal complex	protein binding|RNA binding|transcription corepressor activity|zinc ion binding			ovary(1)|breast(1)|skin(1)	3						GCGGGTCTCTGAGCTCTGCCA	0.488		NA											16	82					0	0	0	0
CFL1	1072	broad.mit.edu	37	11	65623593	65623593	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:65623593C>T	uc001ofs.2	-	2	358	c.124G>A	c.(124-126)GAG>AAG	p.E42K	CFL1_uc001oft.2_Missense_Mutation_p.E42K|CFL1_uc001ofu.2_3'UTR	NM_005507	NP_005498	P23528	COF1_HUMAN	cofilin 1 (non-muscle)	42	ADF-H.				actin cytoskeleton organization|anti-apoptosis|axon guidance|platelet activation|platelet degranulation|response to virus|Rho protein signal transduction	cytoplasm|cytoskeleton|nuclear matrix	actin binding				0				READ - Rectum adenocarcinoma(159;0.169)		TTCTTGTCCTCACTCAGGCAG	0.547		NA											17	56					0	0	0	0
IGHMBP2	3508	broad.mit.edu	37	11	68704300	68704300	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:68704300G>C	uc001ook.1	+	13	2454	c.2352G>C	c.(2350-2352)AAG>AAC	p.K784N	IGHMBP2_uc001ool.1_Missense_Mutation_p.K408N|IGHMBP2_uc001oom.1_Missense_Mutation_p.K362N	NM_002180	NP_002171	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	784	R3H.|SS DNA-binding (By similarity).				cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			CTGTGAGCAAGAGGGCCCCGC	0.682		NA											5	17					0	0	0	0
FCHSD2	9873	broad.mit.edu	37	11	72600885	72600885	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:72600885G>A	uc009ytl.2	-	11	1251	c.1030C>T	c.(1030-1032)CAC>TAC	p.H344Y	FCHSD2_uc010rrg.1_Missense_Mutation_p.H208Y|FCHSD2_uc001oth.3_Missense_Mutation_p.H288Y|FCHSD2_uc001oti.2_Missense_Mutation_p.H303Y	NM_014824	NP_055639	O94868	FCSD2_HUMAN	FCH and double SH3 domains 2	344							protein binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(5;3.3e-05)			CGTTGTTGGTGAACAATGTTT	0.393		NA											7	12					0	0	0	0
PLEKHB1	58473	broad.mit.edu	37	11	73372592	73372592	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:73372592G>C	uc001oua.2	+	8	1108	c.677G>C	c.(676-678)GGA>GCA	p.G226A	PLEKHB1_uc001oub.2_Missense_Mutation_p.G191A|PLEKHB1_uc001ouc.2_Missense_Mutation_p.G207A|PLEKHB1_uc001oud.2_Missense_Mutation_p.G172A|PLEKHB1_uc009ytq.2_Missense_Mutation_p.G172A	NM_021200	NP_067023	Q9UF11	PKHB1_HUMAN	pleckstrin homology domain containing, family B	226					multicellular organismal development|phototransduction	cytoplasm|integral to membrane	signal transducer activity			ovary(1)|lung(1)	2						ATGCTTGCGGGAGCCGCCACT	0.692		NA									OREG0021217	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	62					0	0	0	0
PGM2L1	283209	broad.mit.edu	37	11	74056565	74056565	+	Silent	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:74056565G>C	uc001ovb.1	-	9	1463	c.1167C>G	c.(1165-1167)GTC>GTG	p.V389V		NM_173582	NP_775853	Q6PCE3	PGM2L_HUMAN	phosphoglucomutase 2-like 1	389					glucose 1-phosphate metabolic process	cytosol	glucose-1,6-bisphosphate synthase activity|phosphoglucomutase activity			ovary(1)	1	Breast(11;3.32e-06)					TTTTAGAAGAGACTGTGGTGG	0.333		NA											10	52					0	0	0	0
OR2AT4	341152	broad.mit.edu	37	11	74799889	74799889	+	Silent	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:74799889G>C	uc010rro.1	-	1	870	c.870C>G	c.(868-870)CTC>CTG	p.L290L		NM_001005285	NP_001005285	A6NND4	O2AT4_HUMAN	olfactory receptor, family 2, subfamily AT,	290	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TGAGGGGGTTGAGAATTGGTG	0.483		NA											20	61					0	0	0	0
MRE11A	4361	broad.mit.edu	37	11	94179020	94179020	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:94179020G>C	uc001peu.2	-	16	2012	c.1823C>G	c.(1822-1824)TCA>TGA	p.S608*	MRE11A_uc001pev.2_Intron|MRE11A_uc009ywj.2_Nonsense_Mutation_p.S611*	NM_005591	NP_005582	P49959	MRE11_HUMAN	meiotic recombination 11 homolog A isoform 1	608					DNA duplex unwinding|double-strand break repair via homologous recombination|double-strand break repair via nonhomologous end joining|negative regulation of DNA endoreduplication|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|sister chromatid cohesion|telomere maintenance via telomerase	Mre11 complex|nucleoplasm	3'-5' exonuclease activity|double-stranded DNA binding|manganese ion binding|protein C-terminus binding|single-stranded DNA specific endodeoxyribonuclease activity			breast(4)|lung(1)	5		Acute lymphoblastic leukemia(157;2.37e-05)|all_hematologic(158;0.00824)				AGCAGTCTTTGAGTTCCTGCT	0.378		NA						Homologous_recombination	Ataxia-Telangiectasia-Like_Disorder				32	89					0	0	0	0
BIRC3	330	broad.mit.edu	37	11	102195711	102195711	+	Silent	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:102195711G>A	uc001pgx.2	+	3	693	c.471G>A	c.(469-471)TTG>TTA	p.L157L		NM_182962	NP_892007	Q13489	BIRC3_HUMAN	baculoviral IAP repeat-containing protein 3	157					anti-apoptosis|apoptosis|cell surface receptor linked signaling pathway	cytoplasm|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|skin(1)	4	all_cancers(8;0.00044)|all_epithelial(12;0.00348)|Lung NSC(15;0.227)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0093)	Lung(13;0.109)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0146)		TTTCTGCCTTGATGAGAAGTT	0.408		NA	T	MALT1	MALT								49	150					0	0	0	0
EXPH5	23086	broad.mit.edu	37	11	108384448	108384448	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:108384448C>T	uc001pkk.2	-	6	1897	c.1786G>A	c.(1786-1788)GAG>AAG	p.E596K	EXPH5_uc010rvy.1_Missense_Mutation_p.E408K|EXPH5_uc010rvz.1_Missense_Mutation_p.E440K|EXPH5_uc010rwa.1_Missense_Mutation_p.E520K	NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	596					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		CTTACCAACTCACTAGATTTG	0.418		NA											6	85					0	0	0	0
FDX1	2230	broad.mit.edu	37	11	110306635	110306635	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:110306635C>T	uc001pkx.2	+	2	514	c.263C>T	c.(262-264)TCT>TTT	p.S88F		NM_004109	NP_004100	P10109	ADX_HUMAN	ferredoxin 1 precursor	88	2Fe-2S ferredoxin-type.				electron transport chain|transport	mitochondrial matrix	2 iron, 2 sulfur cluster binding|electron carrier activity|iron ion binding				0		all_cancers(61;1.59e-12)|all_epithelial(67;8.38e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;1.01e-06)|BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|all cancers(92;5.27e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0384)|Colorectal(284;0.228)	Mitotane(DB00648)	GTTGGTGATTCTCTGCTAGAT	0.323		NA											12	39					0	0	0	0
DRD2	1813	broad.mit.edu	37	11	113281596	113281596	+	Silent	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:113281596C>T	uc001pnz.2	-	7	1506	c.1185G>A	c.(1183-1185)CTG>CTA	p.L395L	DRD2_uc010rwv.1_Silent_p.L394L|DRD2_uc001poa.3_Silent_p.L395L|DRD2_uc001pob.3_Silent_p.L366L	NM_000795	NP_000786	P14416	DRD2_HUMAN	dopamine receptor D2 isoform long	395	Helical; Name=6; (By similarity).				activation of phospholipase C activity by dopamine receptor signaling pathway|adenohypophysis development|adult walking behavior|arachidonic acid secretion|axonogenesis|behavioral response to cocaine|behavioral response to ethanol|branching morphogenesis of a nerve|cerebral cortex GABAergic interneuron migration|circadian regulation of gene expression|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|intracellular protein kinase cascade|negative regulation of blood pressure|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of dopamine receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|negative regulation of synaptic transmission, glutamatergic|neurological system process involved in regulation of systemic arterial blood pressure|peristalsis|phosphatidylinositol metabolic process|positive regulation of dopamine uptake|positive regulation of growth hormone secretion|positive regulation of neuroblast proliferation|prepulse inhibition|protein localization|regulation of heart rate|regulation of long-term neuronal synaptic plasticity|regulation of potassium ion transport|regulation of sodium ion transport|regulation of synaptic transmission, GABAergic|release of sequestered calcium ion into cytosol|response to amphetamine|response to drug|response to histamine|response to morphine|sensory perception of smell|synapse assembly|temperature homeostasis|visual learning	integral to plasma membrane	dopamine D2 receptor activity|dopamine receptor activity, coupled via Gi/Go|drug binding|potassium channel regulator activity|protein binding			pancreas(1)|skin(1)	2		all_cancers(61;3.91e-16)|all_epithelial(67;2.95e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000977)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0494)		BRCA - Breast invasive adenocarcinoma(274;5.77e-06)|Epithelial(105;6.66e-05)|all cancers(92;0.000307)|OV - Ovarian serous cystadenocarcinoma(223;0.216)	Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Aripiprazole(DB01238)|Bromocriptine(DB01200)|Buspirone(DB00490)|Cabergoline(DB00248)|Carphenazine(DB01038)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clozapine(DB00363)|Domperidone(DB01184)|Droperidol(DB00450)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Fluspirilene(DB04842)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Mesoridazine(DB00933)|Metoclopramide(DB01233)|Minaprine(DB00805)|Molindone(DB01618)|Olanzapine(DB00334)|Paliperidone(DB01267)|Pergolide(DB01186)|Perphenazine(DB00850)|Pimozide(DB01100)|Pramipexole(DB00413)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Remoxipride(DB00409)|Risperidone(DB00734)|Ropinirole(DB00268)|Sertindole(DB06144)|Sulpiride(DB00391)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trifluoperazine(DB00831)|Triflupromazine(DB00508)|Ziprasidone(DB00246)|Zuclopenthixol(DB01624)	AGTGTATGTTCAGGATGTGTG	0.602		NA											12	42					0	0	0	0
MLL	4297	broad.mit.edu	37	11	118361969	118361969	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:118361969G>A	uc001pta.2	+	14	4778	c.4755G>A	c.(4753-4755)ATG>ATA	p.M1585I	MLL_uc001ptb.2_Missense_Mutation_p.M1585I|MLL_uc001pte.1_RNA	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	1585	PHD-type 3.				apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		AGAGTAAGATGATGCAATGTG	0.398		NA	T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								33	107					0	0	0	0
NTM	50863	broad.mit.edu	37	11	132082033	132082033	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr11:132082033C>G	uc001qgp.2	+	3	1182	c.518C>G	c.(517-519)TCT>TGT	p.S173C	NTM_uc001qgm.2_Missense_Mutation_p.S173C|NTM_uc010sch.1_Missense_Mutation_p.S164C|NTM_uc010sci.1_Missense_Mutation_p.S173C|NTM_uc010scj.1_Missense_Mutation_p.S132C|NTM_uc001qgo.2_Missense_Mutation_p.S173C|NTM_uc001qgq.2_Missense_Mutation_p.S173C|NTM_uc001qgr.2_5'UTR	NM_016522	NP_057606	Q9P121	NTRI_HUMAN	neurotrimin isoform 1	173	Ig-like C2-type 2.				cell adhesion|neuron recognition	anchored to membrane|plasma membrane				ovary(4)|central_nervous_system(1)|skin(1)	6						AGACACATCTCTCCCAAAGGT	0.443		NA											18	66					0	0	0	0
NANOG	79923	broad.mit.edu	37	12	7942253	7942253	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr12:7942253G>C	uc009zfy.1	+	1	259	c.43G>C	c.(43-45)GAA>CAA	p.E15Q		NM_024865	NP_079141	Q9H9S0	NANOG_HUMAN	Nanog homeobox	15					cell proliferation|embryo development|somatic stem cell maintenance	nucleolus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0				Kidney(36;0.0872)		GCCTTGCTTTGAAGCATCCGA	0.438		NA											9	105					0	0	0	0
TAS2R46	259292	broad.mit.edu	37	12	11214128	11214128	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr12:11214128C>G	uc001qzp.1	-	1	766	c.766G>C	c.(766-768)GAA>CAA	p.E256Q	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_176887	NP_795368	P59540	T2R46_HUMAN	taste receptor, type 2, member 46	256	Extracellular (Potential).				sensory perception of taste	cilium membrane|integral to membrane	G-protein coupled receptor activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(49;0.0344)	BRCA - Breast invasive adenocarcinoma(232;0.196)		GGTTTGTTTTCCAGACTCTCA	0.423		NA											18	126					0	0	0	0
LRP6	4040	broad.mit.edu	37	12	12284896	12284896	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr12:12284896C>T	uc001rah.3	-	18	3971	c.3829G>A	c.(3829-3831)GAA>AAA	p.E1277K	BCL2L14_uc001raf.1_Intron|LRP6_uc010shl.1_Intron	NM_002336	NP_002327	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein	1277	Extracellular (Potential).|LDL-receptor class A 1.				cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			lung(4)|skin(4)|ovary(2)|kidney(1)|central_nervous_system(1)	12		Prostate(47;0.0865)				CTGTGGTCTTCACATTCAGTA	0.498		NA											11	51					0	0	0	0
ABCC9	10060	broad.mit.edu	37	12	22015908	22015908	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr12:22015908C>T	uc001rfi.1	-	18	2338	c.2318G>A	c.(2317-2319)GGA>GAA	p.G773E	ABCC9_uc001rfh.2_Missense_Mutation_p.G773E|ABCC9_uc001rfj.1_Missense_Mutation_p.G737E	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	773	Cytoplasmic (Potential).|ABC transporter 1.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	AAAAGGACTTCCAAAAGTAAT	0.343		NA											5	27					0	0	0	0
TSPAN11	441631	broad.mit.edu	37	12	31116785	31116785	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr12:31116785G>A	uc010sju.1	+	3	489	c.109G>A	c.(109-111)GTG>ATG	p.V37M	TSPAN11_uc001rjp.2_Missense_Mutation_p.V37M|TSPAN11_uc010sjv.1_Missense_Mutation_p.V27M	NM_001080509	NP_001073978	A1L157	TSN11_HUMAN	tetraspanin 11	37	Helical; (Potential).					integral to membrane					0	all_lung(12;3.11e-10)|Lung NSC(12;5.24e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Lung SC(12;0.0592)|Esophageal squamous(101;0.233)					CGTCCTGGCTGTGGGCATCTG	0.577		NA											20	52					0	0	0	0
ABCD2	225	broad.mit.edu	37	12	39947792	39947792	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr12:39947792C>G	uc001rmb.2	-	10	2571	c.2145G>C	c.(2143-2145)CAG>CAC	p.Q715H		NM_005164	NP_005155	Q9UBJ2	ABCD2_HUMAN	ATP-binding cassette, sub-family D, member 2	715					fatty acid metabolic process|transport	ATP-binding cassette (ABC) transporter complex|integral to plasma membrane|peroxisomal membrane	ATP binding|ATPase activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)|central_nervous_system(1)|skin(1)	6						CATTGAGTCTCTGCTGCATTT	0.343		NA											6	37					0	0	0	0
ADCY6	112	broad.mit.edu	37	12	49171950	49171950	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr12:49171950G>C	uc001rsh.3	-	2	1615	c.955C>G	c.(955-957)CAG>GAG	p.Q319E	ADCY6_uc001rsj.3_Missense_Mutation_p.Q319E|ADCY6_uc001rsi.3_Missense_Mutation_p.Q319E	NM_015270	NP_056085	O43306	ADCY6_HUMAN	adenylate cyclase 6 isoform a	319	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding				0						CGGGTCTCCTGAAAGGCCTGG	0.632		NA											5	18					0	0	0	0
PRPF40B	25766	broad.mit.edu	37	12	50027427	50027427	+	Silent	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr12:50027427C>G	uc001rur.1	+	8	586	c.522C>G	c.(520-522)GTC>GTG	p.V174V	PRPF40B_uc001rup.1_Silent_p.V196V|PRPF40B_uc001ruq.1_Silent_p.V168V|PRPF40B_uc001rus.1_Silent_p.V117V	NM_001031698	NP_001026868	Q6NWY9	PR40B_HUMAN	Huntingtin interacting protein C isoform 1	174					mRNA processing|RNA splicing	nuclear speck				skin(2)|ovary(1)|pancreas(1)|kidney(1)	5						CAGTTCTAGTCAAACAAGAGG	0.537		NA											4	46					0	0	0	0
KRT74	121391	broad.mit.edu	37	12	52967185	52967185	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr12:52967185T>C	uc001sap.1	-	1	425	c.377A>G	c.(376-378)AAC>AGC	p.N126S		NM_175053	NP_778223	Q7RTS7	K2C74_HUMAN	keratin 6 irs4	126	Head.					keratin filament	structural molecule activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(357;0.191)		CAGCTCCACGTTGAGGGGGGC	0.597		NA											26	65					0	0	0	0
ESYT1	23344	broad.mit.edu	37	12	56531676	56531676	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr12:56531676G>C	uc001sjq.2	+	19	2226	c.2176G>C	c.(2176-2178)GAC>CAC	p.D726H	ESYT1_uc001sjr.2_Missense_Mutation_p.D736H	NM_015292	NP_056107	Q9BSJ8	ESYT1_HUMAN	extended synaptotagmin-like protein 1	726	C2 3.					integral to membrane				ovary(4)|skin(1)	5						CAAGGACTTGGACAAGGATGA	0.488		NA											18	53					0	0	0	0
SLC26A10	65012	broad.mit.edu	37	12	58018660	58018660	+	Silent	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr12:58018660C>T	uc001spe.2	+	10	1550	c.1239C>T	c.(1237-1239)GTC>GTT	p.V413V	SLC26A10_uc001spf.2_RNA|SLC26A10_uc009zpz.1_RNA	NM_133489	NP_597996	Q8NG04	S2610_HUMAN	solute carrier family 26, member 10	413	STAS.					integral to membrane	antiporter activity			large_intestine(1)|central_nervous_system(1)	2	Melanoma(17;0.122)					TCCTCCAGGTCCCGGGGCTCT	0.587		NA											19	69					0	0	0	0
MSRB3	253827	broad.mit.edu	37	12	65722331	65722331	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr12:65722331C>T	uc001ssn.2	+	3	293	c.232C>T	c.(232-234)CAC>TAC	p.H78Y	MSRB3_uc001ssm.2_Missense_Mutation_p.H71Y|MSRB3_uc009zqp.2_Missense_Mutation_p.H71Y	NM_198080	NP_932346	Q8IXL7	MSRB3_HUMAN	methionine sulfoxide reductase B3 isoform 1	78					protein repair	endoplasmic reticulum|mitochondrion	peptide-methionine-(S)-S-oxide reductase activity|protein-methionine-R-oxide reductase activity|zinc ion binding			central_nervous_system(1)|skin(1)	2			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.131)		ATACACACATCACAAAGATCC	0.299		NA											9	46					0	0	0	0
CAND1	55832	broad.mit.edu	37	12	67699870	67699870	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr12:67699870C>T	uc001stn.2	+	10	2859	c.2422C>T	c.(2422-2424)CGA>TGA	p.R808*	CAND1_uc001sto.2_Nonsense_Mutation_p.R318*	NM_018448	NP_060918	Q86VP6	CAND1_HUMAN	TIP120 protein	808	HEAT 18.				cell differentiation|negative regulation of catalytic activity|protein ubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|ubiquitin ligase complex	protein binding			central_nervous_system(1)|skin(1)	2			GBM - Glioblastoma multiforme(1;1.13e-10)|Lung(24;0.000342)|LUSC - Lung squamous cell carcinoma(43;0.196)	GBM - Glioblastoma multiforme(28;0.0279)		TGCCCTTACTCGAGCATGCCC	0.443		NA											31	50					0	0	0	0
PTPRB	5787	broad.mit.edu	37	12	70983837	70983837	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr12:70983837C>T	uc001swb.3	-	6	1333	c.1303G>A	c.(1303-1305)GAC>AAC	p.D435N	PTPRB_uc010sto.1_Missense_Mutation_p.D435N|PTPRB_uc010stp.1_Intron|PTPRB_uc001swc.3_Missense_Mutation_p.D653N|PTPRB_uc001swa.3_Missense_Mutation_p.D653N|PTPRB_uc001swd.3_Missense_Mutation_p.D652N|PTPRB_uc009zrr.1_Missense_Mutation_p.D532N	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	435	Fibronectin type-III 5.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			AGCCCCGTGTCATCCATGACA	0.493		NA									OREG0021990	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	102					0	0	0	0
KCNC2	3747	broad.mit.edu	37	12	75444683	75444683	+	Silent	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr12:75444683G>A	uc001sxg.1	-	3	1646	c.1102C>T	c.(1102-1104)CTG>TTG	p.L368L	KCNC2_uc009zry.2_Silent_p.L368L|KCNC2_uc001sxe.2_Silent_p.L368L|KCNC2_uc001sxf.2_Silent_p.L368L|KCNC2_uc010stw.1_Silent_p.L368L	NM_139137	NP_631875	Q96PR1	KCNC2_HUMAN	Shaw-related voltage-gated potassium channel	368	Helical; Voltage-sensor; Name=Segment S4; (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(2)|pancreas(2)|skin(1)|lung(1)	6						AGCACCCTCAGACCTACAAAA	0.438		NA											19	25					0	0	0	0
ACSS3	79611	broad.mit.edu	37	12	81613830	81613830	+	Silent	SNP	C	C	A	rs142377880		TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr12:81613830C>A	uc001szl.1	+	11	1580	c.1489C>A	c.(1489-1491)CGG>AGG	p.R497R	ACSS3_uc001szm.1_Silent_p.R496R|ACSS3_uc001szn.1_Silent_p.R179R	NM_024560	NP_078836	Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	497						mitochondrion	acetate-CoA ligase activity|ATP binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4						ACTGAAGGCTCGGTGTTTAGG	0.269		NA											7	48					4.69e-08	5.03e-08	1	0
FGD6	55785	broad.mit.edu	37	12	95478362	95478362	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr12:95478362C>G	uc001tdp.3	-	20	4392	c.4168G>C	c.(4168-4170)GAG>CAG	p.E1390Q	FGD6_uc009zsx.2_Missense_Mutation_p.E523Q	NM_018351	NP_060821	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	1390	PH 2.				actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding	p.E1390D(1)		ovary(2)|breast(1)	3						TCGGAATTCTCATCTTTAACT	0.343		NA											25	39					0	0	0	0
ACACB	32	broad.mit.edu	37	12	109613984	109613984	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr12:109613984G>C	uc001tob.2	+	9	1472	c.1353G>C	c.(1351-1353)TTG>TTC	p.L451F	ACACB_uc001toc.2_Missense_Mutation_p.L451F	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	451	Biotin carboxylation.|ATP-grasp.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	GTTTTCCATTGATGATCAAAG	0.512		NA											119	164					0	0	0	0
IFT81	28981	broad.mit.edu	37	12	110628776	110628776	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr12:110628776G>C	uc001tqi.2	+	13	1520	c.1390G>C	c.(1390-1392)GAG>CAG	p.E464Q	IFT81_uc001tqh.2_Missense_Mutation_p.E464Q|IFT81_uc001tqj.2_RNA	NM_001143779	NP_001137251	Q8WYA0	IFT81_HUMAN	intraflagellar transport 81-like isoform 1	464					cell differentiation|multicellular organismal development|spermatogenesis	intraflagellar transport particle B|microtubule-based flagellum				ovary(1)	1						CACCCAAGAAGAGCTAGAAAG	0.338		NA											20	48					0	0	0	0
FBXO21	23014	broad.mit.edu	37	12	117603392	117603392	+	Silent	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr12:117603392C>T	uc001twk.2	-	9	1263	c.1224G>A	c.(1222-1224)CTG>CTA	p.L408L	FBXO21_uc001twj.2_Silent_p.L408L|FBXO21_uc009zwq.2_Silent_p.L348L|FBXO21_uc001twl.1_Silent_p.L21L	NM_033624	NP_296373	O94952	FBX21_HUMAN	F-box only protein 21 isoform 1	408					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	ubiquitin-protein ligase activity			kidney(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0291)		GCGAGTCTCTCAGGAGCTGGT	0.507		NA											7	59					0	0	0	0
P2RX4	5025	broad.mit.edu	37	12	121670829	121670829	+	Silent	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr12:121670829C>T	uc001tzr.2	+	11	1378	c.1074C>T	c.(1072-1074)CTC>CTT	p.L358L	P2RX4_uc009zxc.2_Silent_p.L331L|P2RX4_uc001tzs.2_Silent_p.L374L|P2RX4_uc009zxb.2_RNA|P2RX4_uc010szt.1_Silent_p.L257L	NM_002560	NP_002551	Q99571	P2RX4_HUMAN	purinergic receptor P2X4	358	Helical; Name=2; (Potential).				endothelial cell activation|negative regulation of cardiac muscle hypertrophy|positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling|positive regulation of nitric oxide biosynthetic process|positive regulation of prostaglandin secretion|regulation of apoptosis|regulation of blood pressure|regulation of sodium ion transport|relaxation of cardiac muscle|response to ATP|response to fluid shear stress|sensory perception of pain|tissue homeostasis	cell junction|perinuclear region of cytoplasm	cadherin binding|copper ion binding|extracellular ATP-gated cation channel activity|protein homodimerization activity|purinergic nucleotide receptor activity|receptor binding|zinc ion binding				0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					TCATAGTCCTCTACTGCATGA	0.507		NA											21	232					0	0	0	0
P2RX4	5025	broad.mit.edu	37	12	121670850	121670850	+	Silent	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr12:121670850C>G	uc001tzr.2	+	11	1399	c.1095C>G	c.(1093-1095)CTC>CTG	p.L365L	P2RX4_uc009zxc.2_Silent_p.L338L|P2RX4_uc001tzs.2_Silent_p.L381L|P2RX4_uc009zxb.2_RNA|P2RX4_uc010szt.1_Silent_p.L264L	NM_002560	NP_002551	Q99571	P2RX4_HUMAN	purinergic receptor P2X4	365	Cytoplasmic (Potential).				endothelial cell activation|negative regulation of cardiac muscle hypertrophy|positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling|positive regulation of nitric oxide biosynthetic process|positive regulation of prostaglandin secretion|regulation of apoptosis|regulation of blood pressure|regulation of sodium ion transport|relaxation of cardiac muscle|response to ATP|response to fluid shear stress|sensory perception of pain|tissue homeostasis	cell junction|perinuclear region of cytoplasm	cadherin binding|copper ion binding|extracellular ATP-gated cation channel activity|protein homodimerization activity|purinergic nucleotide receptor activity|receptor binding|zinc ion binding				0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					AGAAAAGACTCTACTATCGGG	0.512		NA											18	202					0	0	0	0
UBC	7316	broad.mit.edu	37	12	125398224	125398224	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr12:125398224C>G	uc001ugs.3	-	2	542	c.94G>C	c.(94-96)GAT>CAT	p.D32H	UBC_uc001ugr.2_5'Flank|UBC_uc001ugu.1_Missense_Mutation_p.D32H|UBC_uc001ugt.2_Missense_Mutation_p.D32H|UBC_uc001ugv.2_Missense_Mutation_p.D32H|UBC_uc001ugw.2_5'UTR|UBC_uc009zyf.1_RNA	NM_021009	NP_066289	P0CG48	UBC_HUMAN	ubiquitin C	32	Ubiquitin-like 1.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.17e-05)|Epithelial(86;0.000207)|all cancers(50;0.00308)		CCTTCCTTATCTTGGATCTTT	0.502		NA											13	175					0	0	0	0
TMEM132D	121256	broad.mit.edu	37	12	129569056	129569056	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr12:129569056G>C	uc009zyl.1	-	6	1963	c.1635C>G	c.(1633-1635)ATC>ATG	p.I545M	TMEM132D_uc001uia.2_Missense_Mutation_p.I83M	NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	545	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		TGCTGGAGACGATGGGCACTC	0.517		NA											5	11					0	0	0	0
GJA3	2700	broad.mit.edu	37	13	20716822	20716822	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr13:20716822G>C	uc001umx.1	-	2	778	c.606C>G	c.(604-606)ATC>ATG	p.I202M		NM_021954	NP_068773	Q9Y6H8	CXA3_HUMAN	connexin 46	202	Helical; (Potential).				cell-cell signaling|visual perception	connexon complex|integral to membrane				pancreas(1)	1		all_cancers(29;1.4e-21)|all_epithelial(30;8.75e-19)|all_lung(29;1.28e-17)|Lung SC(185;0.0257)|Ovarian(182;0.0822)		all cancers(112;0.000554)|Epithelial(112;0.000872)|OV - Ovarian serous cystadenocarcinoma(117;0.0105)|Lung(94;0.0251)|LUSC - Lung squamous cell carcinoma(192;0.0784)		AGATGATGAAGATGGTCTTCT	0.612		NA											13	36					0	0	0	0
SACS	26278	broad.mit.edu	37	13	23912713	23912713	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr13:23912713G>C	uc001uon.2	-	10	5891	c.5302C>G	c.(5302-5304)CAC>GAC	p.H1768D	SACS_uc001uoo.2_Missense_Mutation_p.H1621D|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	1768					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		AACACATGGTGAAATTCTTCC	0.443		NA											22	140					0	0	0	0
PARP4	143	broad.mit.edu	37	13	25026704	25026704	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr13:25026704C>T	uc001upl.2	-	24	2960	c.2854G>A	c.(2854-2856)GAC>AAC	p.D952N	PARP4_uc010tdc.1_Missense_Mutation_p.D952N	NM_006437	NP_006428	Q9UKK3	PARP4_HUMAN	poly (ADP-ribose) polymerase family, member 4	952	VWFA.				cell death|DNA repair|inflammatory response|protein ADP-ribosylation|response to drug|transport	cytoplasm|nucleus|ribonucleoprotein complex|spindle microtubule	DNA binding|enzyme binding|NAD+ ADP-ribosyltransferase activity			ovary(3)|skin(1)	4		all_epithelial(30;7.67e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.000127)|Epithelial(112;0.000778)|Kidney(163;0.039)|OV - Ovarian serous cystadenocarcinoma(117;0.0578)|KIRC - Kidney renal clear cell carcinoma(186;0.135)|Lung(94;0.195)		TTCCAGAAGTCTGTGTTCCCC	0.488		NA											20	62					0	0	0	0
ATP8A2	51761	broad.mit.edu	37	13	26125501	26125501	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr13:26125501G>C	uc001uqk.2	+	11	1059	c.917G>C	c.(916-918)AGA>ACA	p.R306T	ATP8A2_uc010tdi.1_Missense_Mutation_p.R266T|ATP8A2_uc010tdj.1_RNA|ATP8A2_uc001uql.1_Missense_Mutation_p.R266T	NM_016529	NP_057613	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter-like,	266	Cytoplasmic (Potential).				ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|large_intestine(1)|skin(1)	4		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		CCTCTCAAGAGATCAAATGTT	0.507		NA											9	33					0	0	0	0
MTIF3	219402	broad.mit.edu	37	13	28009980	28009980	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr13:28009980G>C	uc001urh.2	-	3	1893	c.669C>G	c.(667-669)TTC>TTG	p.F223L	MTIF3_uc001uri.2_Missense_Mutation_p.F223L|MTIF3_uc001urj.2_Missense_Mutation_p.F223L|MTIF3_uc001urk.2_Missense_Mutation_p.F223L	NM_152912	NP_690876	Q9H2K0	IF3M_HUMAN	mitochondrial translational initiation factor 3	223					regulation of translational initiation|ribosome disassembly	mitochondrion	ribosomal small subunit binding|translation initiation factor activity			ovary(1)|skin(1)	2		Lung SC(185;0.0161)	Colorectal(13;0.00042)|READ - Rectum adenocarcinoma(15;0.105)	all cancers(112;0.108)|OV - Ovarian serous cystadenocarcinoma(117;0.157)		GCCTAGATGAGAATGTAGCTA	0.383		NA											19	61					0	0	0	0
C13orf33	84935	broad.mit.edu	37	13	31495235	31495235	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr13:31495235C>T	uc001uth.3	+	3	814	c.473C>T	c.(472-474)TCA>TTA	p.S158L	uc001utg.1_Intron	NM_032849	NP_116238	Q5VYS4	CM033_HUMAN	hypothetical protein LOC84935	158											0		Lung SC(185;0.0281)		all cancers(112;0.00914)|Epithelial(112;0.0474)|OV - Ovarian serous cystadenocarcinoma(117;0.0559)|GBM - Glioblastoma multiforme(144;0.244)		GTCATCTCCTCAGTGATTGGA	0.483		NA											4	22					0	0	0	0
NBEA	26960	broad.mit.edu	37	13	35751193	35751193	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr13:35751193C>T	uc001uvb.2	+	28	4821	c.4615C>T	c.(4615-4617)CAG>TAG	p.Q1539*	NBEA_uc010abi.2_Nonsense_Mutation_p.Q227*	NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	1539						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		TAGACTTCTTCAGGATGTTGA	0.363		NA											3	8					0	0	0	0
AKAP11	11215	broad.mit.edu	37	13	42876840	42876840	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr13:42876840C>G	uc001uys.1	+	8	4133	c.3958C>G	c.(3958-3960)CTT>GTT	p.L1320V		NM_016248	NP_057332	Q9UKA4	AKA11_HUMAN	A-kinase anchor protein 11	1320					intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			ovary(1)|central_nervous_system(1)	2		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		TCCGTTTATTCTTTCATTACC	0.398		NA											5	45					0	0	0	0
LCP1	3936	broad.mit.edu	37	13	46733075	46733075	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr13:46733075G>C	uc001vaz.3	-	3	240	c.114C>G	c.(112-114)TTC>TTG	p.F38L	LCP1_uc001vba.3_Missense_Mutation_p.F38L	NM_002298	NP_002289	P13796	PLSL_HUMAN	L-plastin	38	EF-hand 1.				regulation of intracellular protein transport|T cell activation involved in immune response	cell junction|cytosol|ruffle membrane	calcium ion binding			lung(4)|ovary(3)	7		Lung NSC(96;1.27e-05)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.39e-05)		AAGCAGCCTTGAACAAGTCAT	0.433		NA	T	BCL6	NHL 								31	90					0	0	0	0
SUCLA2	8803	broad.mit.edu	37	13	48563043	48563043	+	Silent	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr13:48563043G>A	uc001vbs.2	-	3	402	c.345C>T	c.(343-345)CTC>CTT	p.L115L	SUCLA2_uc010tgb.1_Silent_p.L55L|SUCLA2_uc010tgc.1_5'UTR|SUCLA2_uc010tgd.1_Silent_p.L55L|SUCLA2_uc001vbt.1_RNA|SUCLA2_uc001vbu.1_Silent_p.L115L	NM_003850	NP_003841	Q9P2R7	SUCB1_HUMAN	succinate-CoA ligase, ADP-forming, beta subunit	115	ATP-grasp.				succinyl-CoA pathway|tricarboxylic acid cycle	mitochondrial matrix	ATP binding|metal ion binding|protein binding|succinate-CoA ligase (ADP-forming) activity			central_nervous_system(1)	1		all_cancers(8;1.13e-24)|all_epithelial(8;1.78e-13)|all_lung(13;2.85e-06)|Breast(56;0.000141)|Lung NSC(96;0.000226)|all_hematologic(8;0.000885)|Prostate(109;0.00132)|Acute lymphoblastic leukemia(8;0.0167)|Myeloproliferative disorder(33;0.039)|Hepatocellular(98;0.0556)|Lung SC(185;0.102)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(144;2.1e-06)	Succinic acid(DB00139)	CTCCTCCTTTGAGGCCACTTT	0.328		NA											37	118					0	0	0	0
PCDH17	27253	broad.mit.edu	37	13	58207078	58207078	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr13:58207078C>G	uc001vhq.1	+	1	1290	c.398C>G	c.(397-399)TCC>TGC	p.S133C	PCDH17_uc010aec.1_Missense_Mutation_p.S133C	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	133	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		CCCTCCTTCTCCTCGGACCAG	0.612		NA											6	11					0	0	0	0
MYCBP2	23077	broad.mit.edu	37	13	77633702	77633702	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr13:77633702C>T	uc001vkf.2	-	78	13073	c.12982G>A	c.(12982-12984)GAG>AAG	p.E4328K	MYCBP2_uc010aev.2_Missense_Mutation_p.E3732K|MYCBP2_uc001vke.2_Missense_Mutation_p.E945K	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	4328					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		GCAGATAACTCTGTTCCACTC	0.463		NA											8	67					0	0	0	0
MYCBP2	23077	broad.mit.edu	37	13	77699528	77699528	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr13:77699528C>G	uc001vkf.2	-	55	7937	c.7846G>C	c.(7846-7848)GAG>CAG	p.E2616Q	MYCBP2_uc010aev.2_Missense_Mutation_p.E2020Q|MYCBP2_uc001vkg.1_Missense_Mutation_p.E79Q	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	2616					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		GACCATGCCTCTCCTTCATCA	0.433		NA											43	162					0	0	0	0
COL4A2	1284	broad.mit.edu	37	13	111077163	111077163	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr13:111077163G>A	uc001vqx.2	+	5	552	c.263G>A	c.(262-264)GGA>GAA	p.G88E		NM_001846	NP_001837	P08572	CO4A2_HUMAN	alpha 2 type IV collagen preproprotein	88					angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			skin(3)|central_nervous_system(2)|ovary(1)	6	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			GGACGTAAAGGAGACAAGGGT	0.627		NA											13	41					0	0	0	0
ADPRHL1	113622	broad.mit.edu	37	13	114079395	114079395	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr13:114079395T>C	uc001vtq.1	-	5	833	c.746A>G	c.(745-747)GAC>GGC	p.D249G	ADPRHL1_uc001vtp.1_Missense_Mutation_p.D167G	NM_138430	NP_612439	Q8NDY3	ARHL1_HUMAN	ADP-ribosylhydrolase like 1 isoform 1	249					protein de-ADP-ribosylation		ADP-ribosylarginine hydrolase activity|magnesium ion binding				0	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0395)|all_epithelial(44;0.011)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.0195)|GBM - Glioblastoma multiforme(44;0.116)			ATCATAATTGTCGGGGAAGAT	0.299		NA											15	69					0	0	0	0
RASA3	22821	broad.mit.edu	37	13	114781703	114781703	+	Silent	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr13:114781703C>T	uc001vui.2	-	13	1382	c.1251G>A	c.(1249-1251)TTG>TTA	p.L417L	RASA3_uc010tkk.1_Silent_p.L385L|RASA3_uc001vuj.2_Silent_p.L34L	NM_007368	NP_031394	Q14644	RASA3_HUMAN	RAS p21 protein activator 3	417	Ras-GAP.				intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	calcium-release channel activity|metal ion binding|Ras GTPase activator activity			lung(3)|skin(1)	4	Lung NSC(43;0.00814)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.016)|all_epithelial(44;0.00577)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.188)	BRCA - Breast invasive adenocarcinoma(86;0.128)			CTCCGTCTTTCAACTTCACAG	0.517		NA											10	44					0	0	0	0
HOMEZ	57594	broad.mit.edu	37	14	23745036	23745036	+	Silent	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr14:23745036C>T	uc001wja.2	-	2	1549	c.1401G>A	c.(1399-1401)GAG>GAA	p.E467E	HOMEZ_uc001wjb.2_Silent_p.E469E	NM_020834	NP_065885	Q8IX15	HOMEZ_HUMAN	homeodomain leucine zipper protein	467						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	all_cancers(95;5.54e-06)			GBM - Glioblastoma multiforme(265;0.00643)		CCCAGTACCTCTCCAAGGGTT	0.552		NA											6	31					0	0	0	0
L2HGDH	79944	broad.mit.edu	37	14	50734600	50734600	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr14:50734600C>T	uc001wxu.2	-	8	1014	c.935G>A	c.(934-936)GGA>GAA	p.G312E	L2HGDH_uc010tqn.1_Missense_Mutation_p.G312E|L2HGDH_uc010tqo.1_Missense_Mutation_p.G312E	NM_024884	NP_079160	Q9H9P8	L2HDH_HUMAN	L-2-hydroxyglutarate dehydrogenase precursor	312					2-oxoglutarate metabolic process|cellular protein metabolic process	integral to mitochondrial inner membrane	2-hydroxyglutarate dehydrogenase activity			ovary(2)	2	all_epithelial(31;0.000599)|Breast(41;0.0102)					GAAGTGAACTCCTAGGAAAGG	0.423		NA											27	65					0	0	0	0
DAAM1	23002	broad.mit.edu	37	14	59821922	59821922	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr14:59821922C>T	uc001xdz.1	+	21	2551	c.2426C>T	c.(2425-2427)GCC>GTC	p.A809V	DAAM1_uc001xea.1_Missense_Mutation_p.A799V|DAAM1_uc001xec.1_RNA	NM_014992	NP_055807	Q9Y4D1	DAAM1_HUMAN	dishevelled-associated activator of	809	FH2.				actin cytoskeleton organization	cytoplasm|plasma membrane	actin binding|Rho GTPase binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.165)		AGGAGTGGTGCCCTCAAGCAG	0.378		NA											40	118					0	0	0	0
SYNE2	23224	broad.mit.edu	37	14	64691209	64691209	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr14:64691209G>C	uc001xgm.2	+	113	20574	c.20344G>C	c.(20344-20346)GAG>CAG	p.E6782Q	SYNE2_uc001xgl.2_Missense_Mutation_p.E6805Q|SYNE2_uc010apy.2_Missense_Mutation_p.E3167Q|SYNE2_uc001xgn.2_Missense_Mutation_p.E1744Q|SYNE2_uc001xgo.2_RNA|SYNE2_uc010aqa.2_Missense_Mutation_p.E752Q|SYNE2_uc001xgq.2_Missense_Mutation_p.E1161Q|SYNE2_uc001xgr.2_Missense_Mutation_p.E565Q|SYNE2_uc010tsi.1_Missense_Mutation_p.E439Q|SYNE2_uc001xgs.2_Missense_Mutation_p.E453Q|SYNE2_uc001xgt.2_Missense_Mutation_p.E327Q	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	6782	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		CAGCTTCGACGAGGTAGACTC	0.517		NA											9	83					0	0	0	0
SLC8A3	6547	broad.mit.edu	37	14	70518823	70518823	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr14:70518823C>G	uc001xly.2	-	5	2669	c.1915G>C	c.(1915-1917)GAC>CAC	p.D639H	SLC8A3_uc001xlu.2_5'UTR|SLC8A3_uc001xlv.2_Missense_Mutation_p.D10H|SLC8A3_uc001xlw.2_Splice_Site_p.D636_splice|SLC8A3_uc001xlx.2_Splice_Site_p.D637_splice|SLC8A3_uc001xlz.2_Missense_Mutation_p.D633H|SLC8A3_uc010ara.2_RNA|SLC8A3_uc001xma.2_5'UTR	NM_183002	NP_892114	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium	639	Cytoplasmic (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(2)|breast(2)	7				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		AGCTTCCTGTCTGTCACATCT	0.458		NA											24	59					0	0	0	0
YLPM1	56252	broad.mit.edu	37	14	75279341	75279341	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr14:75279341G>C	uc001xqj.3	+	11	5482	c.5358G>C	c.(5356-5358)AGG>AGC	p.R1786S	YLPM1_uc001xql.3_RNA|YLPM1_uc001xqm.1_Missense_Mutation_p.R269S	NM_019589	NP_062535	P49750	YLPM1_HUMAN	YLP motif containing 1	1591					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				ovary(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		GAGAACGAAGGACTTATCCTG	0.443		NA											5	8					0	0	0	0
C14orf166B	145497	broad.mit.edu	37	14	77319682	77319682	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr14:77319682G>C	uc001xsx.2	+	9	1051	c.937G>C	c.(937-939)GAC>CAC	p.D313H	C14orf166B_uc010asn.1_Missense_Mutation_p.D73H|C14orf166B_uc001xsw.2_RNA|C14orf166B_uc010tvg.1_RNA|C14orf166B_uc010tvh.1_RNA	NM_194287	NP_919263	Q0VAA2	CN16B_HUMAN	hypothetical protein LOC145497	313	LRR 7.										0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0306)		CGGTGGCAATGACATCGGCAA	0.507		NA											12	36					0	0	0	0
C14orf166B	145497	broad.mit.edu	37	14	77319694	77319694	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr14:77319694G>A	uc001xsx.2	+	9	1063	c.949G>A	c.(949-951)GAA>AAA	p.E317K	C14orf166B_uc010asn.1_Missense_Mutation_p.E77K|C14orf166B_uc001xsw.2_RNA|C14orf166B_uc010tvg.1_RNA|C14orf166B_uc010tvh.1_RNA	NM_194287	NP_919263	Q0VAA2	CN16B_HUMAN	hypothetical protein LOC145497	317	LRR 7.										0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0306)		CATCGGCAATGAAGGGGCCTC	0.478		NA											7	26					0	0	0	0
PTPN21	11099	broad.mit.edu	37	14	88935898	88935898	+	Silent	SNP	G	G	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr14:88935898G>T	uc001xwv.3	-	17	3511	c.3180C>A	c.(3178-3180)CTC>CTA	p.L1060L	PTPN21_uc010twc.1_Silent_p.L856L	NM_007039	NP_008970	Q16825	PTN21_HUMAN	protein tyrosine phosphatase, non-receptor type	1060	Tyrosine-protein phosphatase.					cytoplasm|cytoskeleton	binding|protein tyrosine phosphatase activity			ovary(3)|skin(1)	4						CTGTGTATTGGAGGTGCCAGA	0.537		NA											5	53					2.77e-08	2.98e-08	1	0
C14orf184	650662	broad.mit.edu	37	14	92040776	92040776	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr14:92040776C>T	uc010aua.1	-	1	608	c.181G>A	c.(181-183)GAG>AAG	p.E61K		NM_001080113	NP_001073582	Q8WYT3	CN184_HUMAN	hypothetical protein LOC650662	61											0						AGCCGCCGCTCGGGTGTACTG	0.657		NA											5	8					0	0	0	0
DDX24	57062	broad.mit.edu	37	14	94528623	94528623	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr14:94528623C>G	uc001ycj.2	-	3	1162	c.1063G>C	c.(1063-1065)GAG>CAG	p.E355Q	DDX24_uc010twq.1_Missense_Mutation_p.E312Q|DDX24_uc010twr.1_Missense_Mutation_p.E105Q	NM_020414	NP_065147	Q9GZR7	DDX24_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 24	355	Helicase ATP-binding.				RNA metabolic process	cytoplasm|nucleolus|nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(2)|kidney(1)|skin(1)	4		all_cancers(154;0.12)		Epithelial(152;0.114)|all cancers(159;0.19)|COAD - Colon adenocarcinoma(157;0.207)		TCCTCATTCTCATTCTGTTTG	0.483		NA											23	70					0	0	0	0
SETD3	84193	broad.mit.edu	37	14	99929847	99929847	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr14:99929847C>G	uc001ygc.2	-	3	342	c.172G>C	c.(172-174)GAG>CAG	p.E58Q	SETD3_uc001ygd.2_Missense_Mutation_p.E58Q|SETD3_uc001ygf.2_Missense_Mutation_p.E58Q	NM_032233	NP_115609	Q86TU7	SETD3_HUMAN	SET domain containing 3 isoform a	58					peptidyl-lysine dimethylation|peptidyl-lysine monomethylation|peptidyl-lysine trimethylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone methyltransferase activity (H3-K36 specific)|transcription coactivator activity				0		all_cancers(154;0.224)|all_epithelial(191;0.0644)|Melanoma(154;0.0866)				CGTATTTTCTCAACCAGAGTC	0.413		NA											4	22					0	0	0	0
EML1	2009	broad.mit.edu	37	14	100405558	100405558	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr14:100405558G>A	uc001ygs.2	+	21	2285	c.2216G>A	c.(2215-2217)GGA>GAA	p.G739E	EML1_uc010tww.1_Missense_Mutation_p.G727E|EML1_uc001ygr.2_Missense_Mutation_p.G758E	NM_004434	NP_004425	O00423	EMAL1_HUMAN	echinoderm microtubule associated protein like 1	739	WD 10.					cytoplasm|microtubule|microtubule associated complex	calcium ion binding|protein binding			large_intestine(2)|pancreas(1)|ovary(1)|skin(1)	5		Melanoma(154;0.0879)|all_epithelial(191;0.216)				GGCTCGGACGGAACCGACATC	0.587		NA											4	40					0	0	0	0
EML1	2009	broad.mit.edu	37	14	100405590	100405590	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr14:100405590G>C	uc001ygs.2	+	21	2317	c.2248G>C	c.(2248-2250)GAG>CAG	p.E750Q	EML1_uc010tww.1_Missense_Mutation_p.E738Q|EML1_uc001ygr.2_Missense_Mutation_p.E769Q	NM_004434	NP_004425	O00423	EMAL1_HUMAN	echinoderm microtubule associated protein like 1	750	WD 10.					cytoplasm|microtubule|microtubule associated complex	calcium ion binding|protein binding			large_intestine(2)|pancreas(1)|ovary(1)|skin(1)	5		Melanoma(154;0.0879)|all_epithelial(191;0.216)				TCGGGCCCATGAGAAGAAACT	0.537		NA											4	33					0	0	0	0
C14orf68	283600	broad.mit.edu	37	14	100789775	100789775	+	Silent	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr14:100789775C>T	uc001yhc.2	+	1	97	c.24C>T	c.(22-24)ATC>ATT	p.I8I	C14orf68_uc001yhd.2_5'UTR	NM_207117	NP_997000	Q6Q0C1	S2547_HUMAN	chromosome 14 open reading frame 68	8	Solcar 1.|Helical; Name=1; (Potential).				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0		Melanoma(154;0.152)				CTGGAGCCATCGGAGGTAACA	0.627		NA											13	17					0	0	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102455173	102455173	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr14:102455173G>C	uc001yks.2	+	10	3016	c.2852G>C	c.(2851-2853)GGA>GCA	p.G951A		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	951	Stem (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						AAGCCTGGTGGAGAGCCAAAG	0.398		NA											11	30					0	0	0	0
HSP90AA1	3320	broad.mit.edu	37	14	102549502	102549502	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr14:102549502C>T	uc001yku.3	-	9	1814	c.1624G>A	c.(1624-1626)GTG>ATG	p.V542M	HSP90AA1_uc001ykv.3_Missense_Mutation_p.V664M|HSP90AA1_uc001ykw.1_Missense_Mutation_p.V363M|HSP90AA1_uc001ykx.1_Missense_Mutation_p.V531M	NM_005348	NP_005339	P07900	HS90A_HUMAN	heat shock 90kDa protein 1, alpha isoform 2	542					axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding			ovary(2)|central_nervous_system(2)|prostate(1)|lung(1)|breast(1)	7					Rifabutin(DB00615)	GTGACTGACACTAAAGTCTTC	0.274		NA											22	77					0	0	0	0
TNFAIP2	7127	broad.mit.edu	37	14	103596165	103596165	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr14:103596165G>A	uc001ymm.1	+	3	1080	c.949G>A	c.(949-951)GAG>AAG	p.E317K	TNFAIP2_uc010awo.1_Intron|TNFAIP2_uc010txz.1_Intron|TNFAIP2_uc010tya.1_5'Flank	NM_006291	NP_006282	Q03169	TNAP2_HUMAN	tumor necrosis factor, alpha-induced protein 2	317					angiogenesis|cell differentiation	extracellular space				central_nervous_system(1)	1		Melanoma(154;0.155)	Epithelial(46;0.191)			CCGACTGCTGGAGGCCACATT	0.662		NA											7	19					0	0	0	0
KLC1	3831	broad.mit.edu	37	14	104129155	104129155	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr14:104129155G>A	uc001yno.2	+	5	996	c.688G>A	c.(688-690)GAG>AAG	p.E230K	KLC1_uc010tyd.1_Missense_Mutation_p.E389K|KLC1_uc010tye.1_Missense_Mutation_p.E226K|KLC1_uc001ynm.1_Missense_Mutation_p.E230K|KLC1_uc001ynn.1_Missense_Mutation_p.E226K|KLC1_uc010tyf.1_Missense_Mutation_p.E230K	NM_182923	NP_891553	Q07866	KLC1_HUMAN	kinesin light chain 1 isoform 2	230	TPR 1.				blood coagulation|microtubule-based movement|stress granule disassembly	cytosol|kinesin complex|microtubule	microtubule motor activity|protein binding				0		Melanoma(154;0.155)|all_epithelial(191;0.19)				GGGGCGCTACGAGGTAGCTGT	0.672		NA											9	19					0	0	0	0
OIP5	11339	broad.mit.edu	37	15	41602045	41602045	+	Silent	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr15:41602045C>G	uc001znp.2	-	5	657	c.597G>C	c.(595-597)CTG>CTC	p.L199L		NM_007280	NP_009211	O43482	MS18B_HUMAN	Opa interacting protein 5	199					cell communication|cell division|CenH3-containing nucleosome assembly at centromere|mitosis	Cajal body|chromatin|chromosome, centromeric region	protein binding				0		all_cancers(109;4.16e-14)|all_epithelial(112;7.09e-12)|Lung NSC(122;1.14e-09)|all_lung(180;2.56e-08)|Melanoma(134;0.091)|Colorectal(260;0.175)		OV - Ovarian serous cystadenocarcinoma(18;1.49e-16)|GBM - Glioblastoma multiforme(113;1.29e-06)|BRCA - Breast invasive adenocarcinoma(123;0.163)		TCTTCTCTTTCAGCTAGGAAG	0.274		NA											20	54					0	0	0	0
CKMT1B	1159	broad.mit.edu	37	15	43891383	43891383	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr15:43891383G>C	uc001zsc.2	+	10	1558	c.1166G>C	c.(1165-1167)GGA>GCA	p.G389A	CKMT1B_uc010uds.1_Missense_Mutation_p.G420A|CKMT1B_uc001zsd.3_Missense_Mutation_p.G389A|CKMT1B_uc010bdj.2_RNA	NM_020990	NP_066270	P12532	KCRU_HUMAN	creatine kinase, mitochondrial 1B precursor	389	Phosphagen kinase C-terminal.				creatine metabolic process	mitochondrial inner membrane	ATP binding|creatine kinase activity				0		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)	Creatine(DB00148)	GTCATCGATGGAGTAAACTAT	0.488		NA											55	119					0	0	0	0
SECISBP2L	9728	broad.mit.edu	37	15	49327631	49327631	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr15:49327631A>G	uc001zxe.1	-	3	562	c.428T>C	c.(427-429)ATC>ACC	p.I143T	SECISBP2L_uc001zxd.1_Missense_Mutation_p.I143T|SECISBP2L_uc010bep.1_5'UTR|SECISBP2L_uc010beq.1_Missense_Mutation_p.I143T	NM_014701	NP_055516	Q93073	SBP2L_HUMAN	SECIS binding protein 2-like	143										breast(1)|skin(1)	2						TTCTGTGGTGATAGCATTTAC	0.483		NA											24	95					0	0	0	0
TMOD2	29767	broad.mit.edu	37	15	52069169	52069169	+	Silent	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr15:52069169C>T	uc002abk.2	+	5	668	c.447C>T	c.(445-447)TTC>TTT	p.F149F	TMOD2_uc002abl.3_Silent_p.F149F|TMOD2_uc010bfb.2_Silent_p.F105F	NM_014548	NP_055363	Q9NZR1	TMOD2_HUMAN	neuronal tropomodulin isoform a	149					nervous system development	cytoplasm|cytoskeleton	actin binding|tropomyosin binding			ovary(2)	2				all cancers(107;0.00435)		ATCCAAAGTTCGATGAAGAAA	0.413		NA											13	38					0	0	0	0
KIAA1370	56204	broad.mit.edu	37	15	52905993	52905993	+	Silent	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr15:52905993C>T	uc002acg.3	-	3	231	c.78G>A	c.(76-78)CTG>CTA	p.L26L	KIAA1370_uc002ach.3_RNA|KIAA1370_uc010bfg.1_Intron|KIAA1370_uc010ugf.1_Silent_p.L33L	NM_019600	NP_062546	Q32MH5	K1370_HUMAN	hypothetical protein LOC56204	26											0				all cancers(107;0.0803)		CTTCTGTTATCAGCAAGGCCA	0.408		NA											11	27					0	0	0	0
ZNF609	23060	broad.mit.edu	37	15	64791723	64791723	+	Silent	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr15:64791723C>T	uc002ann.2	+	1	105	c.105C>T	c.(103-105)ATC>ATT	p.I35I	ZNF609_uc010bgy.2_Silent_p.I35I	NM_015042	NP_055857	O15014	ZN609_HUMAN	zinc finger protein 609	35						nucleus	zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						GGAATCTCATCATTGACCTGG	0.547		NA											16	61					0	0	0	0
CLPX	10845	broad.mit.edu	37	15	65458988	65458988	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr15:65458988G>C	uc002aom.2	-	4	566	c.494C>G	c.(493-495)CCA>CGA	p.P165R	CLPX_uc010uiu.1_RNA|CLPX_uc010bhg.1_Missense_Mutation_p.P165R	NM_006660	NP_006651	O76031	CLPX_HUMAN	ClpX caseinolytic protease X homolog precursor	165					protein folding|proteolysis involved in cellular protein catabolic process	mitochondrial endopeptidase Clp complex|mitochondrial inner membrane|mitochondrial nucleoid	ATP binding|ATPase activity|metal ion binding|peptidase activator activity|unfolded protein binding				0						GGGAGGTGGTGGTTTCTGTTG	0.378		NA											52	137					0	0	0	0
CILP	8483	broad.mit.edu	37	15	65499240	65499240	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr15:65499240C>T	uc002aon.2	-	4	485	c.304G>A	c.(304-306)GCG>ACG	p.A102T		NM_003613	NP_003604	O75339	CILP1_HUMAN	cartilage intermediate layer protein	102					negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				ovary(4)|pancreas(2)|skin(1)	7						GTGCTGCCCGCAGGTGTCCAG	0.627		NA											6	24					0	0	0	0
SMAD3	4088	broad.mit.edu	37	15	67482843	67482843	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr15:67482843C>T	uc002aqj.2	+	9	1545	c.1247C>T	c.(1246-1248)TCC>TTC	p.S416F	SMAD3_uc010ujr.1_Missense_Mutation_p.S311F|SMAD3_uc010ujs.1_Missense_Mutation_p.S372F|SMAD3_uc010ujt.1_Missense_Mutation_p.S221F	NM_005902	NP_005893	P84022	SMAD3_HUMAN	mothers against decapentaplegic homolog 3	416	MH2.				activation of caspase activity|cell cycle arrest|cell-cell junction organization|evasion of host defenses by virus|immune response|induction of apoptosis|negative regulation of cell growth|negative regulation of mitotic cell cycle|negative regulation of protein catabolic process|negative regulation of protein phosphorylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|primary miRNA processing|protein stabilization|regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|SMAD protein complex assembly|transforming growth factor beta receptor signaling pathway|transport|wound healing	cytosol|nuclear inner membrane|receptor complex	beta-catenin binding|co-SMAD binding|metal ion binding|protein homodimerization activity|protein kinase binding|R-SMAD binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transforming growth factor beta receptor binding|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|ubiquitin protein ligase binding			large_intestine(2)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	5				Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(7;0.125)		CAGATGGGCTCCCCAAGCATC	0.547		NA											14	15					0	0	0	0
HCN4	10021	broad.mit.edu	37	15	73615835	73615835	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr15:73615835C>A	uc002avp.2	-	8	3593	c.2599G>T	c.(2599-2601)GCC>TCC	p.A867S		NM_005477	NP_005468	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic	867	Cytoplasmic (Potential).				blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			ovary(5)|liver(1)	6				COAD - Colon adenocarcinoma(1;0.142)		CCAGCGGGGGCAGAGAATCCA	0.692		NA											8	38					0.000157383	0.000164885	1	0
HCN4	10021	broad.mit.edu	37	15	73616079	73616079	+	Silent	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr15:73616079G>A	uc002avp.2	-	8	3349	c.2355C>T	c.(2353-2355)GCC>GCT	p.A785A		NM_005477	NP_005468	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic	785	Cytoplasmic (Potential).				blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			ovary(5)|liver(1)	6				COAD - Colon adenocarcinoma(1;0.142)		TGGTGGCAGCGGCAGCCTGCA	0.701		NA											8	26					0	0	0	0
PML	5371	broad.mit.edu	37	15	74325651	74325651	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr15:74325651C>T	uc002awv.2	+	6	1693	c.1553C>T	c.(1552-1554)TCA>TTA	p.S518L	PML_uc002awm.2_Missense_Mutation_p.S518L|PML_uc002awl.2_Intron|PML_uc002awj.1_Missense_Mutation_p.S470L|PML_uc002awk.2_Missense_Mutation_p.S518L|PML_uc002awn.2_Missense_Mutation_p.S518L|PML_uc002awo.2_Missense_Mutation_p.S470L|PML_uc002awp.2_Intron|PML_uc002awq.2_Missense_Mutation_p.S518L|PML_uc002awr.2_Missense_Mutation_p.S518L|PML_uc002aws.2_Missense_Mutation_p.S470L|PML_uc002awt.2_Intron|PML_uc002awu.2_Missense_Mutation_p.S470L|PML_uc010ule.1_Missense_Mutation_p.S79L|PML_uc002awx.2_Missense_Mutation_p.S228L|PML_uc002awy.2_5'UTR	NM_033238	NP_150241	P29590	PML_HUMAN	promyelocytic leukemia protein isoform 1	518					cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction resulting in induction of apoptosis|endoplasmic reticulum calcium ion homeostasis|induction of apoptosis|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|maintenance of protein location in nucleus|negative regulation of angiogenesis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of mitotic cell cycle|negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of telomerase activity|negative regulation of telomere maintenance via telomerase|negative regulation of transcription, DNA-dependent|negative regulation of translation in response to oxidative stress|PML body organization|PML body organization|positive regulation of defense response to virus by host|positive regulation of histone deacetylation|protein complex assembly|protein stabilization|protein targeting|regulation of calcium ion transport into cytosol|regulation of protein phosphorylation|response to hypoxia|response to virus|transcription, DNA-dependent	cytoplasm|cytosol|early endosome membrane|extrinsic to endoplasmic reticulum membrane|insoluble fraction|nuclear matrix|nuclear membrane|nucleolus|nucleus|PML body	cobalt ion binding|DNA binding|protein binding|protein binding|protein heterodimerization activity|protein homodimerization activity|SUMO binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding|zinc ion binding			central_nervous_system(2)|kidney(2)|breast(1)	5						AAGGCAGTCTCACCACCCCAC	0.657		NA	T	RARA|PAX5	APL|ALL								9	28					0	0	0	0
GOLGA6A	342096	broad.mit.edu	37	15	74365132	74365132	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr15:74365132C>G	uc002axa.1	-	13	1493	c.1452G>C	c.(1450-1452)CAG>CAC	p.Q484H		NM_001038640	NP_001033729	Q9NYA3	GOG6A_HUMAN	golgi autoantigen, golgin subfamily a, 6	484	Potential.										0						GCTGTTGGTTCTGGTGGCTGG	0.622		NA											5	85					0	0	0	0
SGK269	79834	broad.mit.edu	37	15	77471990	77471990	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr15:77471990C>T	uc002bcm.2	-	3	2587	c.2279G>A	c.(2278-2280)AGA>AAA	p.R760K	SGK269_uc002bcn.2_Missense_Mutation_p.R760K	NM_024776	NP_079052	Q9H792	PEAK1_HUMAN	NKF3 kinase family member	760					cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding				0				STAD - Stomach adenocarcinoma(199;0.124)		TGCTTTCTCTCTGGTGCTGCT	0.537		NA											32	72					0	0	0	0
CPEB1	64506	broad.mit.edu	37	15	83221346	83221346	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr15:83221346C>A	uc002bit.2	-	8	1416	c.1279G>T	c.(1279-1281)GAA>TAA	p.E427*	CPEB1_uc002biq.2_Nonsense_Mutation_p.E287*|CPEB1_uc002bir.2_Nonsense_Mutation_p.E292*|CPEB1_uc002bis.2_Nonsense_Mutation_p.E287*|CPEB1_uc010uod.1_Nonsense_Mutation_p.E136*|CPEB1_uc010uoe.1_Nonsense_Mutation_p.E365*|CPEB1_uc002biu.2_Nonsense_Mutation_p.E389*|CPEB1_uc010uof.1_Nonsense_Mutation_p.E287*|CPEB1_uc002biv.2_Nonsense_Mutation_p.E362*|CPEB1_uc002bip.2_Nonsense_Mutation_p.E136*	NM_001079533	NP_001073001	Q9BZB8	CPEB1_HUMAN	cytoplasmic polyadenylation element binding	367	RRM 1.|Necessary for stress granule assembly and correct localization in dcp1 bodies.				mRNA processing|regulation of translation	cell junction|cytoplasmic mRNA processing body|dendrite|postsynaptic density|postsynaptic membrane	nucleotide binding|RNA binding			ovary(1)|breast(1)	2			BRCA - Breast invasive adenocarcinoma(143;0.229)			TTCTCTAGTTCGAAGACCAGA	0.493		NA											18	56					4.97e-08	5.32e-08	1	0
POLG	5428	broad.mit.edu	37	15	89862269	89862269	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr15:89862269C>T	uc002bns.3	-	20	3448	c.3166G>A	c.(3166-3168)GAA>AAA	p.E1056K	POLG_uc002bnr.3_Missense_Mutation_p.E1056K	NM_002693	NP_002684	P54098	DPOG1_HUMAN	DNA-directed DNA polymerase gamma	1056					base-excision repair, gap-filling|cell death|DNA-dependent DNA replication	mitochondrial nucleoid	DNA binding|DNA-directed DNA polymerase activity|protease binding			ovary(1)|lung(1)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)		STAD - Stomach adenocarcinoma(125;0.165)			TTGAACATTTCTGACTCTGTG	0.562		NA						DNA_polymerases_(catalytic_subunits)					6	93					0	0	0	0
PRC1	9055	broad.mit.edu	37	15	91510405	91510405	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr15:91510405C>G	uc002bqm.2	-	15	1976	c.1819G>C	c.(1819-1821)GAT>CAT	p.D607H	PRC1_uc002bqn.2_Missense_Mutation_p.D593H|PRC1_uc002bqo.2_Nonstop_Mutation_p.*567S|PRC1_uc010uqs.1_Nonstop_Mutation_p.*526S	NM_003981	NP_003972	O43663	PRC1_HUMAN	protein regulator of cytokinesis 1 isoform 1	607	Unstructured, Arg/Lys rich.				cytokinesis|mitotic spindle elongation	cytoplasm|nucleus|spindle microtubule|spindle pole	protein binding			ovary(1)|skin(1)	2	Lung NSC(78;0.0987)|all_lung(78;0.175)					GAAGTAGCATCAGATTTGGAA	0.448		NA											22	55					0	0	0	0
XYLT1	64131	broad.mit.edu	37	16	17235129	17235129	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr16:17235129C>G	uc002dfa.2	-	7	1553	c.1468G>C	c.(1468-1470)GAT>CAT	p.D490H		NM_022166	NP_071449	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	490	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			ovary(4)	4						GAACCGCCATCCACGGCAATG	0.567		NA											38	102					0	0	0	0
CD2BP2	10421	broad.mit.edu	37	16	30365574	30365574	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr16:30365574C>T	uc002dxr.2	-	2	401	c.148G>A	c.(148-150)GAT>AAT	p.D50N	CD2BP2_uc002dxs.2_Missense_Mutation_p.D50N	NM_006110	NP_006101	O95400	CD2B2_HUMAN	CD2 antigen (cytoplasmic tail) binding protein	50					assembly of spliceosomal tri-snRNP	cytoplasm|nucleoplasm|U5 snRNP	protein binding|ribonucleoprotein binding			ovary(1)	1						TCCTCCTCATCGCTATCCAAA	0.527		NA											61	189					0	0	0	0
SLC5A2	6524	broad.mit.edu	37	16	31499472	31499472	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr16:31499472G>C	uc002ecf.3	+	8	1018	c.999G>C	c.(997-999)ATG>ATC	p.M333I	SLC5A2_uc010car.2_RNA|C16orf58_uc002ecg.2_RNA	NM_003041	NP_003032	P31639	SC5A2_HUMAN	solute carrier family 5 (sodium/glucose	333	Helical; (Potential).				carbohydrate metabolic process	integral to membrane	low-affinity glucose:sodium symporter activity			ovary(1)	1						TGCCAGGCATGATCAGCCGCA	0.627		NA											24	90					0	0	0	0
OGFOD1	55239	broad.mit.edu	37	16	56492471	56492471	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr16:56492471G>C	uc002ejb.2	+	3	413	c.312G>C	c.(310-312)TTG>TTC	p.L104F	OGFOD1_uc002ejc.2_5'UTR	NM_018233	NP_060703	Q8N543	OGFD1_HUMAN	2-oxoglutarate and iron-dependent oxygenase	104							iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			skin(1)	1					Vitamin C(DB00126)	CTGATGATTTGAAGAAGAGAA	0.279		NA											7	31					0	0	0	0
OGFOD1	55239	broad.mit.edu	37	16	56492479	56492479	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr16:56492479G>A	uc002ejb.2	+	3	421	c.320G>A	c.(319-321)AGA>AAA	p.R107K	OGFOD1_uc002ejc.2_5'UTR	NM_018233	NP_060703	Q8N543	OGFD1_HUMAN	2-oxoglutarate and iron-dependent oxygenase	107							iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			skin(1)	1					Vitamin C(DB00126)	TTGAAGAAGAGAAGAGAGCCT	0.259		NA											7	31					0	0	0	0
BBS2	583	broad.mit.edu	37	16	56535295	56535295	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr16:56535295G>C	uc002ejd.2	-	10	1429	c.1195C>G	c.(1195-1197)CAT>GAT	p.H399D	BBS2_uc010ccg.2_3'UTR	NM_031885	NP_114091	Q9BXC9	BBS2_HUMAN	Bardet-Biedl syndrome 2 protein	399					adult behavior|brain morphogenesis|cerebral cortex development|cilium morphogenesis|fat cell differentiation|hippocampus development|melanosome transport|negative regulation of multicellular organism growth|photoreceptor cell maintenance|protein localization to organelle|regulation of cilium beat frequency involved in ciliary motility|sperm axoneme assembly|striatum development	BBSome|cilium membrane|microtubule basal body|motile cilium	protein binding			ovary(1)	1						AATTCTGTATGAGCAGTTTGG	0.473		NA							Bardet-Biedl_syndrome				36	127					0	0	0	0
TEPP	374739	broad.mit.edu	37	16	58019836	58019836	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr16:58019836C>G	uc002emw.3	+	7	813	c.776C>G	c.(775-777)TCC>TGC	p.S259C	TEPP_uc002emv.3_Missense_Mutation_p.S286C	NM_199456	NP_955535	Q6URK8	TEPP_HUMAN	testis/prostate/placenta-expressed protein	259						extracellular region				kidney(1)|central_nervous_system(1)|skin(1)	3						AGCTTCGGCTCCAGCTACAGG	0.652		NA											8	46					0	0	0	0
CCDC113	29070	broad.mit.edu	37	16	58296295	58296295	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr16:58296295G>C	uc002ene.2	+	6	713	c.634G>C	c.(634-636)GAG>CAG	p.E212Q	CCDC113_uc010vid.1_Missense_Mutation_p.E158Q	NM_014157	NP_054876	Q9H0I3	CC113_HUMAN	coiled-coil domain containing 113 isoform 1	212	Potential.					protein complex					0						GTAGAAGGAAGAGGTGAGTGA	0.418		NA											29	94					0	0	0	0
GOT2	2806	broad.mit.edu	37	16	58757719	58757719	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr16:58757719C>G	uc002eof.1	-	2	291	c.177G>C	c.(175-177)AAG>AAC	p.K59N	GOT2_uc010vim.1_Missense_Mutation_p.K59N	NM_002080	NP_002071	P00505	AATM_HUMAN	aspartate aminotransferase 2 precursor	59					aspartate catabolic process|fatty acid transport|gluconeogenesis|response to ethanol	mitochondrial matrix|plasma membrane	L-aspartate:2-oxoglutarate aminotransferase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(1)|skin(1)	2					L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	CCAGATTCATCTTTTTGCTAT	0.493		NA											41	137					0	0	0	0
LRRC36	55282	broad.mit.edu	37	16	67405069	67405069	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr16:67405069G>C	uc002esv.2	+	9	1437	c.1418G>C	c.(1417-1419)AGA>ACA	p.R473T	LRRC36_uc002esw.2_RNA|LRRC36_uc010ceh.2_Missense_Mutation_p.R205T|LRRC36_uc002esx.2_Missense_Mutation_p.R352T|LRRC36_uc010vjk.1_Missense_Mutation_p.R352T|LRRC36_uc010vjl.1_5'UTR|LRRC36_uc002esy.2_Intron	NM_018296	NP_060766	Q1X8D7	LRC36_HUMAN	leucine rich repeat containing 36 isoform 1	473											0		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0669)|Epithelial(162;0.161)		CCATCGAAGAGAGGATTCAAA	0.468		NA											23	90					0	0	0	0
FAM65A	79567	broad.mit.edu	37	16	67573997	67573997	+	Silent	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr16:67573997C>T	uc010vjp.1	+	7	612	c.516C>T	c.(514-516)CTC>CTT	p.L172L	FAM65A_uc010cei.1_5'UTR|FAM65A_uc002eth.2_Silent_p.L152L|FAM65A_uc010cej.2_Silent_p.L155L|FAM65A_uc002eti.1_Silent_p.L115L|FAM65A_uc010vjq.1_Silent_p.L166L|FAM65A_uc002etj.1_Silent_p.L151L|FAM65A_uc002etk.2_Silent_p.L151L	NM_024519	NP_078795	Q6ZS17	FA65A_HUMAN	hypothetical protein LOC79567	156						cytoplasm	binding			ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0474)|Epithelial(162;0.117)		AGCGGCGTCTCCGGGATGGTG	0.637		NA											30	72					0	0	0	0
HAS3	3038	broad.mit.edu	37	16	69148496	69148496	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr16:69148496G>A	uc010cfh.2	+	4	1213	c.989G>A	c.(988-990)CGA>CAA	p.R330Q	HAS3_uc002ewk.2_Intron|HAS3_uc002ewl.2_Missense_Mutation_p.R330Q	NM_005329	NP_005320	O00219	HAS3_HUMAN	hyaluronan synthase 3 isoform a	330	Cytoplasmic (Potential).				carbohydrate metabolic process	integral to plasma membrane	hyaluronan synthase activity				0		Ovarian(137;0.101)		OV - Ovarian serous cystadenocarcinoma(108;0.0694)		CTTGGCTACCGAACTAAGTAT	0.582		NA											16	40					0	0	0	0
COG4	25839	broad.mit.edu	37	16	70553601	70553601	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr16:70553601C>G	uc002ezc.2	-	2	216	c.205G>C	c.(205-207)GAA>CAA	p.E69Q	COG4_uc010cfu.2_RNA|COG4_uc002ezd.2_Missense_Mutation_p.E69Q|COG4_uc002eze.2_Intron	NM_015386	NP_056201	Q9H9E3	COG4_HUMAN	component of oligomeric golgi complex 4	65	Interacts with SCFD1.				Golgi organization|Golgi vesicle prefusion complex stabilization|protein transport|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding				0		Ovarian(137;0.0694)				TTTTGCTGTTCCAAAAGAGCA	0.378		NA											4	24					0	0	0	0
ZCCHC14	23174	broad.mit.edu	37	16	87451158	87451158	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr16:87451158G>C	uc002fjz.1	-	8	907	c.880C>G	c.(880-882)CAG>GAG	p.Q294E	ZCCHC14_uc002fka.1_RNA|ZCCHC14_uc002fkb.2_Missense_Mutation_p.Q70E	NM_015144	NP_055959	Q8WYQ9	ZCH14_HUMAN	zinc finger, CCHC domain containing 14	294					cell communication		nucleic acid binding|phosphatidylinositol binding|zinc ion binding			upper_aerodigestive_tract(1)|breast(1)	2				BRCA - Breast invasive adenocarcinoma(80;0.0285)		TCCTGGGTCTGAGGGGTCTGC	0.572		NA											46	132					0	0	0	0
CPNE7	27132	broad.mit.edu	37	16	89655212	89655212	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr16:89655212G>A	uc002fnp.2	+	12	1412	c.1282G>A	c.(1282-1284)GAC>AAC	p.D428N	CPNE7_uc002fnq.2_Missense_Mutation_p.D353N	NM_014427	NP_055242	Q9UBL6	CPNE7_HUMAN	copine 7 isoform b	428	VWFA.				lipid metabolic process		transporter activity				0		all_hematologic(23;0.0748)		all cancers(4;3.63e-08)|OV - Ovarian serous cystadenocarcinoma(4;1.7e-06)|BRCA - Breast invasive adenocarcinoma(80;0.0147)		CCAGGACTATGACAGGTGCGC	0.642		NA											13	26					0	0	0	0
VPS53	55275	broad.mit.edu	37	17	455171	455171	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:455171G>A	uc002frn.2	-	17	1954	c.1807C>T	c.(1807-1809)CAG>TAG	p.Q603*	VPS53_uc002frk.2_Nonsense_Mutation_p.Q122*|VPS53_uc010cjo.1_Nonsense_Mutation_p.Q603*|VPS53_uc002frl.2_RNA|VPS53_uc002frm.2_Nonsense_Mutation_p.Q574*|VPS53_uc002fro.2_Nonsense_Mutation_p.Q405*|VPS53_uc010cjp.1_Nonsense_Mutation_p.Q326*	NM_018289	NP_060759	Q5VIR6	VPS53_HUMAN	vacuolar protein sorting 53 isoform 2	603					protein transport	endosome membrane|Golgi apparatus					0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0265)		ACCAGCAGCTGAATACTGCTG	0.502		NA											5	9					0	0	0	0
GEMIN4	50628	broad.mit.edu	37	17	649539	649539	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:649539G>C	uc002frs.1	-	2	1863	c.1744C>G	c.(1744-1746)CTC>GTC	p.L582V		NM_015721	NP_056536	P57678	GEMI4_HUMAN	gemin 4	582					rRNA processing|spliceosomal snRNP assembly	Cajal body|cytosol|nucleolus|small nuclear ribonucleoprotein complex|spliceosomal complex	protein binding			ovary(2)|kidney(1)|skin(1)	4		Myeloproliferative disorder(207;0.204)		UCEC - Uterine corpus endometrioid carcinoma (25;0.022)		AAGGCAGTGAGAATCTGGGCC	0.547		NA											16	41					0	0	0	0
OR1A1	8383	broad.mit.edu	37	17	3119610	3119610	+	Silent	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:3119610C>T	uc010vrc.1	+	1	696	c.696C>T	c.(694-696)GGC>GGT	p.G232G		NM_014565	NP_055380	Q9P1Q5	OR1A1_HUMAN	olfactory receptor, family 1, subfamily A,	232	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						CCACCAAGGGCGTGCTCAAGG	0.483		NA											35	108					0	0	0	0
YBX2	51087	broad.mit.edu	37	17	7192869	7192869	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:7192869G>A	uc002gfq.2	-	7	1081	c.1024C>T	c.(1024-1026)CGG>TGG	p.R342W		NM_015982	NP_057066	Q9Y2T7	YBOX2_HUMAN	Y box binding protein 2	342	Pro-rich.|Required for mRNA-binding.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter|translational attenuation	cytoplasm|nucleus	DNA binding				0						GCGGGCTGCCGGGGGCCAGGG	0.667		NA											6	11					0	0	0	0
NEURL4	84461	broad.mit.edu	37	17	7228995	7228995	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:7228995G>C	uc002gga.1	-	7	1338	c.1331C>G	c.(1330-1332)TCT>TGT	p.S444C	NEURL4_uc002ggb.1_Missense_Mutation_p.S444C|NEURL4_uc002ggc.1_5'UTR	NM_032442	NP_115818	Q96JN8	NEUL4_HUMAN	neuralized homolog 4 isoform 1	444	NHR 2.						protein binding			upper_aerodigestive_tract(1)|ovary(1)	2						GTGTAGGGCAGAGTTGGACTT	0.567		NA											25	86					0	0	0	0
FXR2	9513	broad.mit.edu	37	17	7496331	7496331	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:7496331G>A	uc002gia.1	-	13	1726	c.1499C>T	c.(1498-1500)TCG>TTG	p.S500L	SOX15_uc002ghy.1_5'Flank|SOX15_uc002ghz.1_5'Flank	NM_004860	NP_004851	P51116	FXR2_HUMAN	fragile X mental retardation syndrome related	500						cytosolic large ribosomal subunit	protein binding|RNA binding				0				READ - Rectum adenocarcinoma(115;0.17)		ATTGTATCTCGAAGTGGGCCG	0.617		NA											10	44					0	0	0	0
KDM6B	23135	broad.mit.edu	37	17	7752247	7752247	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:7752247G>A	uc002giw.1	+	11	3017	c.2641G>A	c.(2641-2643)GAG>AAG	p.E881K	KDM6B_uc002gix.2_Missense_Mutation_p.E183K	NM_001080424	NP_001073893	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	881	Pro-rich.				inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|pancreas(1)	2						CTGGGCCCGGGAGCGCAGGGC	0.716		NA											4	11					0	0	0	0
KDM6B	23135	broad.mit.edu	37	17	7753196	7753196	+	Silent	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:7753196G>A	uc002giw.1	+	12	3874	c.3498G>A	c.(3496-3498)GTG>GTA	p.V1166V	KDM6B_uc002gix.2_Silent_p.V468V	NM_001080424	NP_001073893	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	1166					inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|pancreas(1)	2						CCCAGTCTGTGAAACCGAAGA	0.532		NA											40	120					0	0	0	0
NCOR1	9611	broad.mit.edu	37	17	15942786	15942786	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:15942786C>T	uc002gpo.2	-	44	7156	c.6916G>A	c.(6916-6918)GAG>AAG	p.E2306K	NCOR1_uc002gpn.2_Missense_Mutation_p.E2203K|NCOR1_uc002gpl.2_Missense_Mutation_p.E321K|NCOR1_uc002gpm.2_Missense_Mutation_p.E826K|NCOR1_uc010vwb.1_Missense_Mutation_p.E890K|NCOR1_uc010coy.2_Missense_Mutation_p.E1214K	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	2306	Interaction with C1D (By similarity).				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		CTTCGTGTCTCACCACTGGTC	0.483		NA											7	36					0	0	0	0
NCOR1	9611	broad.mit.edu	37	17	16029434	16029434	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:16029434C>G	uc002gpo.2	-	15	1836	c.1596G>C	c.(1594-1596)AAG>AAC	p.K532N	NCOR1_uc002gpn.2_Missense_Mutation_p.K532N|NCOR1_uc002gpp.1_Missense_Mutation_p.K423N|NCOR1_uc002gpr.2_Missense_Mutation_p.K423N|NCOR1_uc002gps.1_Missense_Mutation_p.K541N|NCOR1_uc010coz.1_Missense_Mutation_p.K348N|NCOR1_uc010cpb.1_Missense_Mutation_p.K542N|NCOR1_uc010cpa.1_Missense_Mutation_p.K533N	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	532	Potential.				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		cttcatctttcttttcttctt	0.114		NA											3	7					0	0	0	0
SREBF1	6720	broad.mit.edu	37	17	17719301	17719301	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:17719301C>G	uc002gru.1	-	12	2450	c.2256G>C	c.(2254-2256)CAG>CAC	p.Q752H	SREBF1_uc002grp.1_Missense_Mutation_p.Q371H|SREBF1_uc002grq.1_Missense_Mutation_p.Q271H|SREBF1_uc002grr.1_Missense_Mutation_p.Q498H|SREBF1_uc002grs.1_Missense_Mutation_p.Q728H|SREBF1_uc002grt.1_Missense_Mutation_p.Q782H|MIR33B_hsa-mir-33b|MI0003646_5'Flank	NM_004176	NP_004167	P36956	SRBP1_HUMAN	sterol regulatory element binding transcription	752	Cytoplasmic (Potential).				cellular response to starvation|cholesterol metabolic process|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter	endoplasmic reticulum|endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleus	protein binding|protein binding|sequence-specific DNA binding transcription factor activity|sterol response element binding			skin(1)	1						CTGAGCCACTCTGTGCCAGGC	0.667		NA											5	43					0	0	0	0
SMCR8	140775	broad.mit.edu	37	17	18220060	18220060	+	Silent	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:18220060G>A	uc002gsy.3	+	1	1467	c.957G>A	c.(955-957)TTG>TTA	p.L319L		NM_144775	NP_658988	Q8TEV9	SMCR8_HUMAN	Smith-Magenis syndrome chromosome region,	319										central_nervous_system(1)	1						ACAAGAAGTTGAAGACCTTGG	0.493		NA											18	55					0	0	0	0
NOS2	4843	broad.mit.edu	37	17	26114730	26114730	+	Silent	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:26114730G>A	uc002gzu.2	-	5	705	c.441C>T	c.(439-441)GTC>GTT	p.V147V	NOS2_uc010crh.1_Silent_p.V147V|NOS2_uc010wab.1_Silent_p.V147V	NM_000625	NP_000616	P35228	NOS2_HUMAN	nitric oxide synthase 2A	147					arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			skin(2)|ovary(1)|breast(1)	4					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	AATATTGGTTGACAAATTCGA	0.537		NA											23	82					0	0	0	0
SGK494	124923	broad.mit.edu	37	17	26940613	26940613	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:26940613C>T	uc002hbr.1	-	2	201	c.169G>A	c.(169-171)GAA>AAA	p.E57K	SGK494_uc010waq.1_Missense_Mutation_p.E57K|SGK494_uc010war.1_RNA|uc010crq.1_5'Flank|uc002hbs.1_Intron	NM_144610	NP_653211			uncharacterized serine/threonine-protein kinase												0						CCCCGTAGTTCCCAGAGTTCT	0.582		NA									OREG0024279	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	81					0	0	0	0
CCDC55	84081	broad.mit.edu	37	17	28506198	28506198	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:28506198G>C	uc002heu.2	+	5	419	c.391G>C	c.(391-393)GAA>CAA	p.E131Q	CCDC55_uc002hev.2_Missense_Mutation_p.E77Q|CCDC55_uc010wbl.1_Missense_Mutation_p.E77Q|CCDC55_uc010wbm.1_Missense_Mutation_p.E77Q|CCDC55_uc002hex.2_Missense_Mutation_p.E77Q	NM_032141	NP_115517	Q9H0G5	NSRP1_HUMAN	coiled-coil domain containing 55 isoform 1	131	Necessary for alternative splicing activity.|Potential.				developmental process|nucleocytoplasmic transport|regulation of alternative nuclear mRNA splicing, via spliceosome	nuclear speck|ribonucleoprotein complex	mRNA binding|protein binding				0						GAGAGAACGAGAAATGGAAAA	0.353		NA											5	19					0	0	0	0
GGNBP2	79893	broad.mit.edu	37	17	34937844	34937844	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:34937844G>A	uc002hnb.2	+	9	1340	c.1091G>A	c.(1090-1092)CGA>CAA	p.R364Q	GGNBP2_uc002hna.2_Missense_Mutation_p.R364Q|GGNBP2_uc002hnc.1_Missense_Mutation_p.R193Q	NM_024835	NP_079111	Q9H3C7	GGNB2_HUMAN	zinc finger protein 403	364					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasmic membrane-bounded vesicle				ovary(2)	2		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0193)		GAAGAGGAACGAGTAAGAGAA	0.368		NA											29	60					0	0	0	0
CDC6	990	broad.mit.edu	37	17	38450695	38450695	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:38450695G>C	uc002huj.1	+	7	1233	c.1023G>C	c.(1021-1023)TTG>TTC	p.L341F		NM_001254	NP_001245	Q99741	CDC6_HUMAN	cell division cycle 6 protein	341					cell division|DNA replication|DNA replication checkpoint|M/G1 transition of mitotic cell cycle|mitosis|negative regulation of cell proliferation|negative regulation of DNA replication|positive regulation of cell cycle cytokinesis|positive regulation of chromosome segregation|regulation of cyclin-dependent protein kinase activity|regulation of mitotic anaphase|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|traversing start control point of mitotic cell cycle	cytosol|nucleoplasm|spindle midzone|spindle pole	ATP binding|kinase binding|nucleoside-triphosphatase activity			ovary(2)|breast(1)	3						CACAGCTGTTGAACTTCCCAC	0.398		NA											20	70					0	0	0	0
KRT10	3858	broad.mit.edu	37	17	38978336	38978336	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:38978336C>A	uc002hvi.2	-	1	528	c.502G>T	c.(502-504)GAA>TAA	p.E168*	KRT10_uc010cxd.2_5'Flank|TMEM99_uc002hvj.1_Intron	NM_000421	NP_000412	P13645	K1C10_HUMAN	keratin 10	168	Coil 1A.|Rod.|Gly-rich.				epidermis development		protein binding|structural constituent of epidermis				0		Breast(137;0.000301)				TTTGATTCTTCCAGAGCCCGA	0.438		NA											32	109					1.56e-20	1.7e-20	1	0
FKBP10	60681	broad.mit.edu	37	17	39975508	39975508	+	Silent	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:39975508G>C	uc002hxv.2	+	5	1099	c.774G>C	c.(772-774)CTG>CTC	p.L258L	FKBP10_uc002hxw.1_5'UTR	NM_021939	NP_068758	Q96AY3	FKB10_HUMAN	FK506 binding protein 10 precursor	258	PPIase FKBP-type 2.				protein folding	endoplasmic reticulum lumen|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity			ovary(1)	1		Breast(137;0.00122)		BRCA - Breast invasive adenocarcinoma(366;0.148)		ACGTCCTCCTGATTGACGTGC	0.632		NA											27	73					0	0	0	0
KCNH4	23415	broad.mit.edu	37	17	40318431	40318431	+	Missense_Mutation	SNP	G	G	A	rs140560707		TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:40318431G>A	uc002hzb.2	-	10	2057	c.1724C>T	c.(1723-1725)TCG>TTG	p.S575L		NM_012285	NP_036417	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H,	575	Cytoplasmic (Potential).|cNMP.				regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			large_intestine(1)	1		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		AGCGCAGAACGAGGTCTTGAT	0.622		NA											4	24					0	0	0	0
KCNH4	23415	broad.mit.edu	37	17	40318439	40318439	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:40318439G>C	uc002hzb.2	-	10	2049	c.1716C>G	c.(1714-1716)ATC>ATG	p.I572M		NM_012285	NP_036417	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H,	572	Cytoplasmic (Potential).|cNMP.				regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			large_intestine(1)	1		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		ACGAGGTCTTGATGTGCAGCG	0.627		NA											5	21					0	0	0	0
STAT5B	6777	broad.mit.edu	37	17	40362425	40362425	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:40362425C>T	uc002hzh.2	-	14	1940	c.1771G>A	c.(1771-1773)GAT>AAT	p.D591N		NM_012448	NP_036580	P51692	STA5B_HUMAN	signal transducer and activator of transcription	591	SH2.				2-oxoglutarate metabolic process|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|fatty acid metabolic process|isoleucine metabolic process|JAK-STAT cascade involved in growth hormone signaling pathway|oxaloacetate metabolic process|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cytosol|nucleoplasm	calcium ion binding|glucocorticoid receptor binding|sequence-specific DNA binding transcription factor activity			ovary(3)|lung(2)|skin(1)	6		all_cancers(22;4.15e-07)|all_epithelial(22;2.83e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.135)	Dasatinib(DB01254)	TCTCACCCATCATTCCAATGA	0.448		NA											19	87					0	0	0	0
CNTNAP1	8506	broad.mit.edu	37	17	40843231	40843231	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:40843231C>G	uc002iay.2	+	14	2352	c.2136C>G	c.(2134-2136)ATC>ATG	p.I712M	CNTNAP1_uc010wgs.1_RNA	NM_003632	NP_003623	P78357	CNTP1_HUMAN	contactin associated protein 1 precursor	712	Extracellular (Potential).|Fibrinogen C-terminal.				axon guidance|cell adhesion	paranode region of axon	receptor activity|receptor binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(3)|breast(3)|upper_aerodigestive_tract(1)|lung(1)	8		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.143)		AGCCTGGGATCCAGCGCTGTG	0.617		NA											13	95					0	0	0	0
ADAM11	4185	broad.mit.edu	37	17	42855094	42855094	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:42855094G>A	uc002ihh.2	+	23	1933	c.1933G>A	c.(1933-1935)GAC>AAC	p.D645N	ADAM11_uc010wjd.1_Missense_Mutation_p.D445N|ADAM11_uc002ihi.2_5'UTR	NM_002390	NP_002381	O75078	ADA11_HUMAN	ADAM metallopeptidase domain 11 preproprotein	645	Cys-rich.|Extracellular (Potential).				integrin-mediated signaling pathway|proteolysis	integral to membrane|plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			pancreas(1)	1		Prostate(33;0.0959)				GGACGGCTCTGACCTGAGCTA	0.642		NA											9	31					0	0	0	0
NMT1	4836	broad.mit.edu	37	17	43159088	43159088	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:43159088G>A	uc002ihz.2	+	2	226	c.208G>A	c.(208-210)GAG>AAG	p.E70K	NMT1_uc010dac.1_Intron|NMT1_uc002iia.2_RNA	NM_021079	NP_066565	P30419	NMT1_HUMAN	N-myristoyltransferase 1	70					activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals|N-terminal protein myristoylation|protein lipoylation	actin cytoskeleton|cell junction|cytosol	glycylpeptide N-tetradecanoyltransferase activity				0		Prostate(33;0.155)				aaaaGGCAGTGAGACAGATTC	0.348		NA											7	8					0	0	0	0
NMT1	4836	broad.mit.edu	37	17	43159090	43159090	+	Silent	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:43159090G>A	uc002ihz.2	+	2	228	c.210G>A	c.(208-210)GAG>GAA	p.E70E	NMT1_uc010dac.1_Intron|NMT1_uc002iia.2_RNA	NM_021079	NP_066565	P30419	NMT1_HUMAN	N-myristoyltransferase 1	70					activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals|N-terminal protein myristoylation|protein lipoylation	actin cytoskeleton|cell junction|cytosol	glycylpeptide N-tetradecanoyltransferase activity				0		Prostate(33;0.155)				aaGGCAGTGAGACAGATTCAG	0.348		NA											5	7					0	0	0	0
MAP3K14	9020	broad.mit.edu	37	17	43364681	43364681	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:43364681C>A	uc002iiw.1	-	4	485	c.376G>T	c.(376-378)GAG>TAG	p.E126*	MAP3K14_uc010daj.1_5'Flank|MAP3K14_uc002iiv.1_5'UTR	NM_003954	NP_003945	Q99558	M3K14_HUMAN	mitogen-activated protein kinase kinase kinase	126					cellular response to mechanical stimulus|I-kappaB kinase/NF-kappaB cascade|immune response|positive regulation of I-kappaB kinase/NF-kappaB cascade|T cell costimulation	cytosol	ATP binding|MAP kinase kinase kinase activity|NF-kappaB-inducing kinase activity|protein binding			central_nervous_system(3)|breast(2)|lung(1)|ovary(1)|stomach(1)	8						ATTTTGCCCTCTGTAGCATGG	0.493		NA											7	31					0.000157383	0.000164885	1	0
CALCOCO2	10241	broad.mit.edu	37	17	46926688	46926688	+	Silent	SNP	C	C	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:46926688C>A	uc002iof.2	+	5	571	c.492C>A	c.(490-492)ATC>ATA	p.I164I	CALCOCO2_uc010wlp.1_Silent_p.I185I|CALCOCO2_uc010wlq.1_Silent_p.I92I|CALCOCO2_uc010wlr.1_Silent_p.I188I|CALCOCO2_uc010wls.1_Intron	NM_005831	NP_005822	Q13137	CACO2_HUMAN	calcium binding and coiled-coil domain 2	164	Potential.				response to interferon-gamma|viral reproduction	cytoskeleton|Golgi apparatus|nucleus|perinuclear region of cytoplasm|soluble fraction	protein homodimerization activity			ovary(1)	1						ACAGCTGTATCAGCCTCCAGA	0.473		NA											32	72					2.68e-12	2.9e-12	1	0
ZNF652	22834	broad.mit.edu	37	17	47388699	47388699	+	Silent	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:47388699G>A	uc002iov.3	-	5	1748	c.1284C>T	c.(1282-1284)TTC>TTT	p.F428F	ZNF652_uc002iow.2_Silent_p.F428F|ZNF652_uc002iou.3_RNA	NM_001145365	NP_001138837	Q9Y2D9	ZN652_HUMAN	zinc finger protein 652	428	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)	1	all_cancers(4;6.81e-14)|Breast(4;4.97e-29)|all_epithelial(4;1.53e-17)		BRCA - Breast invasive adenocarcinoma(1;3.1e-14)|Epithelial(5;2.92e-06)|all cancers(6;3.15e-05)			TGTGTTCGTCGAAGTACTGCT	0.423		NA											24	79					0	0	0	0
CACNA1G	8913	broad.mit.edu	37	17	48646576	48646576	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:48646576G>C	uc002irk.1	+	3	777	c.405G>C	c.(403-405)AAG>AAC	p.K135N	CACNA1G_uc002iri.1_Missense_Mutation_p.K135N|CACNA1G_uc002irj.1_Missense_Mutation_p.K135N|CACNA1G_uc002irl.1_Missense_Mutation_p.K135N|CACNA1G_uc002irm.1_Missense_Mutation_p.K135N|CACNA1G_uc002irn.1_Missense_Mutation_p.K135N|CACNA1G_uc002iro.1_Missense_Mutation_p.K135N|CACNA1G_uc002irp.1_Missense_Mutation_p.K135N|CACNA1G_uc002irq.1_Missense_Mutation_p.K135N|CACNA1G_uc002irr.1_Missense_Mutation_p.K135N|CACNA1G_uc002irs.1_Missense_Mutation_p.K135N|CACNA1G_uc002irt.1_Missense_Mutation_p.K135N|CACNA1G_uc002irv.1_Missense_Mutation_p.K135N|CACNA1G_uc002irw.1_Missense_Mutation_p.K135N|CACNA1G_uc002iru.1_Missense_Mutation_p.K135N|CACNA1G_uc002irx.1_Missense_Mutation_p.K48N|CACNA1G_uc002iry.1_Missense_Mutation_p.K48N|CACNA1G_uc002irz.1_Missense_Mutation_p.K48N|CACNA1G_uc002isa.1_Missense_Mutation_p.K48N|CACNA1G_uc002isb.1_Missense_Mutation_p.K48N|CACNA1G_uc002isc.1_Missense_Mutation_p.K48N|CACNA1G_uc002isd.1_Missense_Mutation_p.K48N|CACNA1G_uc002ise.1_Missense_Mutation_p.K48N|CACNA1G_uc002isf.1_Missense_Mutation_p.K48N|CACNA1G_uc002isg.1_Missense_Mutation_p.K48N|CACNA1G_uc002ish.1_Missense_Mutation_p.K48N|CACNA1G_uc002isi.1_Missense_Mutation_p.K48N	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	135	Helical; Name=S2 of repeat I; (Potential).|I.				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	TGGTGGTGAAGATGGTGGCCT	0.527		NA											9	32					0	0	0	0
TUBD1	51174	broad.mit.edu	37	17	57963531	57963531	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:57963531G>A	uc002ixw.1	-	3	511	c.233C>T	c.(232-234)TCA>TTA	p.S78L	TUBD1_uc010ddf.1_Missense_Mutation_p.S78L|TUBD1_uc010ddg.1_Missense_Mutation_p.S43L|TUBD1_uc010ddh.1_5'UTR|TUBD1_uc010wok.1_Missense_Mutation_p.S78L|TUBD1_uc002ixx.1_Missense_Mutation_p.S78L|TUBD1_uc010wol.1_Intron|TUBD1_uc010ddi.1_Intron	NM_016261	NP_057345	Q9UJT1	TBD_HUMAN	delta-tubulin	78					cell differentiation|microtubule-based movement|multicellular organismal development|protein polymerization|spermatogenesis	centriole|microtubule|nucleus	GTP binding|GTPase activity|structural molecule activity			ovary(1)	1	all_cancers(5;3.18e-13)|Breast(5;2.91e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;9.34e-13)|all cancers(12;1.91e-11)			GGCAGCCTTTGACAGCATTTG	0.413		NA											6	75					0	0	0	0
USP32	84669	broad.mit.edu	37	17	58288742	58288742	+	Silent	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:58288742G>C	uc002iyo.1	-	20	2599	c.2313C>G	c.(2311-2313)CTC>CTG	p.L771L	USP32_uc002iyn.1_Silent_p.L441L	NM_032582	NP_115971	Q8NFA0	UBP32_HUMAN	ubiquitin specific protease 32	771					protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|breast(2)|large_intestine(1)	5	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)			ATTACCTGTTGAGTTCATAAA	0.408		NA											8	120					0	0	0	0
CYB561	1534	broad.mit.edu	37	17	61512584	61512584	+	Silent	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:61512584G>A	uc002jap.2	-	4	828	c.426C>T	c.(424-426)TTC>TTT	p.F142F	CYB561_uc002jaq.2_Silent_p.F188F|CYB561_uc002jar.2_Silent_p.F142F|CYB561_uc002jas.2_Silent_p.F142F|CYB561_uc010ddt.2_Missense_Mutation_p.S158F|CYB561_uc002jat.2_Silent_p.F142F|CYB561_uc010wpf.1_Intron|CYB561_uc010wpg.1_Silent_p.F113F	NM_001915	NP_001906	P49447	CY561_HUMAN	cytochrome b-561	142	Helical; (Potential).|Cytochrome b561.				electron transport chain|transport	integral to plasma membrane	cytochrome-b5 reductase activity|ferric-chelate reductase activity|metal ion binding			ovary(1)	1				READ - Rectum adenocarcinoma(1115;0.0689)		GGAACAGGAAGAAGCTGAAGC	0.642		NA											11	43					0	0	0	0
KCNH6	81033	broad.mit.edu	37	17	61611639	61611639	+	Silent	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:61611639C>T	uc002jay.2	+	5	1148	c.1068C>T	c.(1066-1068)TTC>TTT	p.F356F	KCNH6_uc002jax.1_Silent_p.F356F|KCNH6_uc010wpl.1_Silent_p.F233F|KCNH6_uc010wpm.1_Silent_p.F356F|KCNH6_uc002jaz.1_Silent_p.F356F	NM_030779	NP_110406	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H,	356	Helical; Name=Segment S3; (Potential).				regulation of transcription, DNA-dependent|signal transduction					skin(1)	1					Ibutilide(DB00308)	CCATCCCTTTCGACCTCCTGA	0.622		NA											15	36					0	0	0	0
ABCA9	10350	broad.mit.edu	37	17	66972084	66972084	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:66972084C>T	uc002jhu.2	-	39	4990	c.4847G>A	c.(4846-4848)TGG>TAG	p.W1616*	ABCA9_uc010dez.2_Nonsense_Mutation_p.W1578*	NM_080283	NP_525022	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A, member 9	1616					transport	integral to membrane	ATP binding|ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	Breast(10;1.47e-12)					GAGGAGTTTCCACTTCACCGA	0.408		NA											3	12					0	0	0	0
CCDC40	55036	broad.mit.edu	37	17	78063659	78063659	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:78063659G>A	uc010dht.2	+	17	2835	c.2808G>A	c.(2806-2808)ATG>ATA	p.M936I	CCDC40_uc002jxm.3_Missense_Mutation_p.M719I|CCDC40_uc002jxn.3_Missense_Mutation_p.M332I	NM_017950	NP_060420	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	936	Potential.				axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				ovary(3)	3	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			TCCGGGCCATGAAGGGCGAGA	0.582		NA											6	29					0	0	0	0
RNF213	57674	broad.mit.edu	37	17	78317686	78317686	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:78317686C>G	uc002jyh.1	+	3	655	c.432C>G	c.(430-432)TTC>TTG	p.F144L		NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment								p.F144L(1)		ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			TGTTTCTTTTCAAGCTCCTCA	0.438		NA											18	89					0	0	0	0
C17orf90	339229	broad.mit.edu	37	17	79632428	79632428	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:79632428C>A	uc002kba.2	-	2	258	c.247G>T	c.(247-249)GAG>TAG	p.E83*	C17orf90_uc002kbb.2_3'UTR|CCDC137_uc002kbc.3_5'Flank|CCDC137_uc002kbd.2_5'Flank	NM_001039842	NP_001034931	Q5BKU9	CQ090_HUMAN	hypothetical protein LOC339229	83											0	all_neural(118;0.0878)|all_lung(278;0.23)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0739)			GGCTGGAGCTCAGGTGGCAGC	0.657		NA											8	23					1.77e-08	1.9e-08	1	0
PTPRM	5797	broad.mit.edu	37	18	8370921	8370921	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr18:8370921G>C	uc002knn.3	+	22	3552	c.3049G>C	c.(3049-3051)GAG>CAG	p.E1017Q	PTPRM_uc010dkv.2_Missense_Mutation_p.E1030Q|PTPRM_uc010wzl.1_Missense_Mutation_p.E804Q	NM_002845	NP_002836	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	1017	Tyrosine-protein phosphatase 1.|Cytoplasmic (Potential).				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			lung(3)|ovary(2)|central_nervous_system(1)	6		Colorectal(10;0.234)				AGATGACACAGAGATATATAA	0.348		NA											9	74					0	0	0	0
ANKRD12	23253	broad.mit.edu	37	18	9256444	9256444	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr18:9256444C>G	uc002knv.2	+	9	3436	c.3179C>G	c.(3178-3180)TCA>TGA	p.S1060*	ANKRD12_uc002knw.2_Nonsense_Mutation_p.S1037*|ANKRD12_uc002knx.2_Nonsense_Mutation_p.S1037*|ANKRD12_uc010dkx.1_Nonsense_Mutation_p.S767*	NM_015208	NP_056023	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12 isoform 1	1060						nucleus				ovary(2)|central_nervous_system(1)	3						TCACCAGCATCAAAAGATACC	0.289		NA											24	106					0	0	0	0
TXNDC2	84203	broad.mit.edu	37	18	9887362	9887362	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr18:9887362G>A	uc002koi.3	+	2	1335	c.886G>A	c.(886-888)GAG>AAG	p.E296K	TXNDC2_uc010wzq.1_Intron|TXNDC2_uc002koh.3_Missense_Mutation_p.E229K	NM_001098529	NP_001091999	Q86VQ3	TXND2_HUMAN	thioredoxin domain-containing 2 isoform 2	296	13.|22 X 15 AA approximate tandem repeat of Q-P-K-X-G-D-I-P-K-S-[PS]-E-[KE]-X-I.				cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	cytoplasm	electron carrier activity|nutrient reservoir activity|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			ovary(1)|pancreas(1)	2						CCAGCCCAAGGAGGGTGACCT	0.602		NA											32	73					0	0	0	0
KIAA1328	57536	broad.mit.edu	37	18	34802101	34802101	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr18:34802101C>G	uc002kzz.2	+	10	1667	c.1645C>G	c.(1645-1647)CTA>GTA	p.L549V	KIAA1328_uc002lab.2_3'UTR|KIAA1328_uc002lac.1_Missense_Mutation_p.L408V|KIAA1328_uc010dnc.1_RNA	NM_020776	NP_065827	Q86T90	K1328_HUMAN	hypothetical protein LOC57536	549										central_nervous_system(1)	1				COAD - Colon adenocarcinoma(74;0.195)		ACTCAGTCCTCTAAAATCAAC	0.473		NA											5	5					0	0	0	0
TCEB3C	162699	broad.mit.edu	37	18	44555035	44555035	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr18:44555035C>G	uc010xdb.1	-	1	1415	c.1179G>C	c.(1177-1179)TGG>TGC	p.W393C	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_145653	NP_663628	Q8NG57	ELOA3_HUMAN	transcription elongation factor B polypeptide	393	Activation domain (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane|nucleus	DNA binding				0						AATGAATCCTCCATAATTCAT	0.577		NA											7	221					0	0	0	0
TCEB3B	51224	broad.mit.edu	37	18	44560858	44560858	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr18:44560858C>G	uc002lcr.1	-	1	1131	c.778G>C	c.(778-780)GAG>CAG	p.E260Q	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_016427	NP_057511	Q8IYF1	ELOA2_HUMAN	elongin A2	260					regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			ovary(2)|large_intestine(1)|pancreas(1)	4						GGGGTTTCCTCTCTTAAGCAG	0.597		NA											13	57					0	0	0	0
ATP8B1	5205	broad.mit.edu	37	18	55359051	55359051	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr18:55359051G>C	uc002lgw.2	-	11	1208	c.1208C>G	c.(1207-1209)TCT>TGT	p.S403C	uc002lgv.1_Intron	NM_005603	NP_005594	O43520	AT8B1_HUMAN	ATPase, class I, type 8B, member 1	403	Helical; (Potential).		S -> Y (in PFIC1).		ATP biosynthetic process|bile acid and bile salt transport|negative regulation of transcription, DNA-dependent	apical plasma membrane|integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(5)|ovary(2)|central_nervous_system(2)|lung(1)	10		Colorectal(73;0.229)				GACATAGAGAGAGATGGGTAC	0.443		NA							Byler_disease				8	37					0	0	0	0
PHLPP1	23239	broad.mit.edu	37	18	60642651	60642651	+	Silent	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr18:60642651G>A	uc002lis.2	+	17	2419	c.2241G>A	c.(2239-2241)CAG>CAA	p.Q747Q		NM_194449	NP_919431	O60346	PHLP1_HUMAN	PH domain and leucine rich repeat protein	1259	PP2C-like.				apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling	cytosol|membrane|nucleus	metal ion binding|protein serine/threonine phosphatase activity				0						CTGCTGGGCAGAAGCTTGGTG	0.527		NA											7	84					0	0	0	0
DOK6	220164	broad.mit.edu	37	18	67365819	67365819	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr18:67365819G>C	uc002lkl.2	+	5	779	c.589G>C	c.(589-591)GAG>CAG	p.E197Q		NM_152721	NP_689934	Q6PKX4	DOK6_HUMAN	docking protein 6	197	IRS-type PTB.						insulin receptor binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3		Colorectal(73;0.083)|Esophageal squamous(42;0.131)				GTTCACGTTTGAGTCAGGAAG	0.478		NA											3	17					0	0	0	0
DOK6	220164	broad.mit.edu	37	18	67406304	67406304	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr18:67406304G>A	uc002lkl.2	+	6	893	c.703G>A	c.(703-705)GAA>AAA	p.E235K		NM_152721	NP_689934	Q6PKX4	DOK6_HUMAN	docking protein 6	235	IRS-type PTB.						insulin receptor binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3		Colorectal(73;0.083)|Esophageal squamous(42;0.131)				TGAGCAACATGAAAGATTAAT	0.448		NA											10	106					0	0	0	0
CNDP2	55748	broad.mit.edu	37	18	72183552	72183552	+	Silent	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr18:72183552G>A	uc002llm.1	+	9	1155	c.993G>A	c.(991-993)GTG>GTA	p.V331V	CNDP2_uc002lln.1_Silent_p.V247V|CNDP2_uc010dqs.2_Intron	NM_018235	NP_060705	Q96KP4	CNDP2_HUMAN	CNDP dipeptidase 2	331						cytoplasm	carboxypeptidase activity|metal ion binding|metallopeptidase activity|protein binding|tripeptidase activity			ovary(2)|skin(1)	3		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.22)		CCAAGACCGTGATTCCCAGGA	0.597		NA											14	48					0	0	0	0
SBNO2	22904	broad.mit.edu	37	19	1109708	1109708	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:1109708G>A	uc002lrk.3	-	27	3335	c.3097C>T	c.(3097-3099)CAG>TAG	p.Q1033*	SBNO2_uc002lri.3_5'Flank|SBNO2_uc002lrj.3_Nonsense_Mutation_p.Q976*|SBNO2_uc010dse.2_Nonsense_Mutation_p.Q1016*|SBNO2_uc010xgj.1_Intron	NM_014963	NP_055778	Q9Y2G9	SBNO2_HUMAN	strawberry notch homolog 2 isoform 1	1033					macrophage activation involved in immune response|negative regulation of transcription, DNA-dependent|regulation of inflammatory response|transcription, DNA-dependent						0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGCCCGTCCTGCGGGTGCCCG	0.672		NA											10	34					0	0	0	0
AP3D1	8943	broad.mit.edu	37	19	2110821	2110821	+	Silent	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:2110821G>A	uc002luz.2	-	25	3097	c.2874C>T	c.(2872-2874)AGC>AGT	p.S958S	AP3D1_uc010dsv.2_Silent_p.S48S|AP3D1_uc002luy.2_Silent_p.S917S|AP3D1_uc002lva.2_Silent_p.S1020S	NM_003938	NP_003929	O14617	AP3D1_HUMAN	adaptor-related protein complex 3, delta 1	958					eye pigment biosynthetic process|intracellular protein transport|regulation of sequestering of zinc ion|vesicle-mediated transport	endosome membrane|Golgi membrane|membrane coat	binding|protein transporter activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGAGGATGCTGCTGCTCCTGT	0.642		NA											8	36					0	0	0	0
TLE2	7089	broad.mit.edu	37	19	3028341	3028341	+	Silent	SNP	C	C	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:3028341C>A	uc002lww.2	-	3	425	c.162G>T	c.(160-162)ACG>ACT	p.T54T	TLE2_uc010xhb.1_5'Flank|TLE2_uc010dth.2_Silent_p.T54T|TLE2_uc010xhc.1_5'UTR|TLE2_uc010dti.2_Silent_p.T67T|TLE2_uc010xhd.1_Silent_p.T54T	NM_003260	NP_003251	Q04725	TLE2_HUMAN	transducin-like enhancer protein 2 isoform 1	54	Gln-rich.				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription corepressor activity				0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCTGCATTTCCGTCTTCTCGC	0.507		NA											4	10					0.000602214	0.000625187	1	0
DOHH	83475	broad.mit.edu	37	19	3494056	3494056	+	Silent	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:3494056C>T	uc002lxs.2	-	3	484	c.321G>A	c.(319-321)CTG>CTA	p.L107L	DOHH_uc010xhl.1_Silent_p.L107L	NM_031304	NP_112594	Q9BU89	DOHH_HUMAN	deoxyhypusine hydroxylase/monooxygenase	107	HEAT-like PBS-type 2.				peptidyl-lysine modification to hypusine|post-translational protein modification	cytosol	deoxyhypusine monooxygenase activity|metal ion binding|protein binding				0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)		AATACTGCTTCAGGATCTCCA	0.642		NA											4	15					0	0	0	0
DOHH	83475	broad.mit.edu	37	19	3494073	3494073	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:3494073C>T	uc002lxs.2	-	3	467	c.304G>A	c.(304-306)GAA>AAA	p.E102K	DOHH_uc010xhl.1_Missense_Mutation_p.E102K	NM_031304	NP_112594	Q9BU89	DOHH_HUMAN	deoxyhypusine hydroxylase/monooxygenase	102	HEAT-like PBS-type 2.				peptidyl-lysine modification to hypusine|post-translational protein modification	cytosol	deoxyhypusine monooxygenase activity|metal ion binding|protein binding				0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)		TCCAGAACTTCCGGGTCCCCG	0.632		NA											5	14					0	0	0	0
SAFB2	9667	broad.mit.edu	37	19	5622555	5622555	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:5622555C>G	uc002mcd.2	-	1	384	c.172G>C	c.(172-174)GAG>CAG	p.E58Q	SAFB_uc010xiq.1_5'Flank|SAFB_uc002mcf.2_5'Flank|SAFB_uc002mcg.2_5'Flank|SAFB_uc002mce.3_5'Flank|SAFB_uc010xir.1_5'Flank|SAFB_uc010xis.1_5'Flank|SAFB_uc010xit.1_5'Flank|SAFB_uc010xiu.1_5'Flank|SAFB2_uc010xio.1_Missense_Mutation_p.E58Q|SAFB2_uc010xip.1_RNA	NM_014649	NP_055464	Q14151	SAFB2_HUMAN	scaffold attachment factor B2	58	SAP.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|nucleotide binding|protein binding|RNA binding				0				UCEC - Uterine corpus endometrioid carcinoma (162;0.000228)		TTGAGCCGCTCCATCAGGACG	0.731		NA											8	12					0	0	0	0
RFX2	5990	broad.mit.edu	37	19	6007164	6007164	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:6007164C>T	uc002meb.2	-	12	1530	c.1261G>A	c.(1261-1263)GAG>AAG	p.E421K	RFX2_uc002mec.2_Missense_Mutation_p.E396K|RFX2_uc002med.1_3'UTR	NM_000635	NP_000626	P48378	RFX2_HUMAN	regulatory factor X2 isoform a	421					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(4)|ovary(1)|skin(1)	6						ACGGCGCCCTCGGGGTCTTCG	0.667		NA											7	27					0	0	0	0
TNFSF14	8740	broad.mit.edu	37	19	6665352	6665352	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:6665352G>C	uc002mfk.1	-	5	690	c.308C>G	c.(307-309)TCC>TGC	p.S103C	TNFSF14_uc002mfj.1_Missense_Mutation_p.S67C	NM_003807	NP_003798	O43557	TNF14_HUMAN	tumor necrosis factor ligand superfamily, member	103	Extracellular (Potential).				cellular response to mechanical stimulus|immune response|induction of apoptosis|release of cytoplasmic sequestered NF-kappaB|T cell homeostasis|T cell proliferation	cytoplasm|extracellular space|integral to membrane|plasma membrane	caspase inhibitor activity|cytokine activity|tumor necrosis factor receptor binding			skin(1)	1						GGTCAAGCTGGAGTTGGCCCC	0.532		NA											3	3					0	0	0	0
VAV1	7409	broad.mit.edu	37	19	6833552	6833552	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:6833552C>G	uc002mfu.1	+	17	1721	c.1624C>G	c.(1624-1626)CAG>GAG	p.Q542E	VAV1_uc010xjh.1_Missense_Mutation_p.Q510E|VAV1_uc010dva.1_Missense_Mutation_p.Q542E|VAV1_uc002mfv.1_Missense_Mutation_p.Q487E	NM_005428	NP_005419	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	542	Phorbol-ester/DAG-type.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(4)|ovary(4)|breast(3)|central_nervous_system(2)|kidney(2)|skin(1)	16						TACCTTCTATCAGGGCTACCG	0.547		NA											20	95					0	0	0	0
MYO1F	4542	broad.mit.edu	37	19	8587564	8587564	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:8587564C>T	uc002mkg.2	-	26	3118	c.3004G>A	c.(3004-3006)GAG>AAG	p.E1002K		NM_012335	NP_036467	O00160	MYO1F_HUMAN	myosin IF	1002						unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(1)	3						GTGTTGTGCTCTGAGGGCGGA	0.687		NA											7	24					0	0	0	0
ADAMTS10	81794	broad.mit.edu	37	19	8650504	8650504	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:8650504C>T	uc002mkj.1	-	23	2975	c.2701G>A	c.(2701-2703)GAT>AAT	p.D901N	ADAMTS10_uc002mki.1_Missense_Mutation_p.D388N|ADAMTS10_uc002mkk.1_Missense_Mutation_p.D533N	NM_030957	NP_112219	Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1	901	TSP type-1 3.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			pancreas(2)|skin(2)	4						ACGCCTGCATCGCAGCTGCGG	0.672		NA											7	13					0	0	0	0
ZNF177	7730	broad.mit.edu	37	19	9492159	9492159	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:9492159G>C	uc002mli.2	+	12	1335	c.672G>C	c.(670-672)AAG>AAC	p.K224N	ZNF177_uc002mlj.2_Missense_Mutation_p.K174N|ZNF177_uc002mlk.2_Missense_Mutation_p.K224N	NM_003451	NP_003442	Q13360	ZN177_HUMAN	zinc finger protein 177	224	C2H2-type 4.				negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CATCCCTTAAGAAACACACAC	0.463		NA											16	131					0	0	0	0
EIF3G	8666	broad.mit.edu	37	19	10226442	10226442	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:10226442G>T	uc002mnd.2	-	9	822	c.758C>A	c.(757-759)ACC>AAC	p.T253N		NM_003755	NP_003746	O75821	EIF3G_HUMAN	eukaryotic translation initiation factor 3,	253	RRM.					cytosol|eukaryotic translation initiation factor 3 complex|nucleus|perinuclear region of cytoplasm	nucleotide binding|protein binding|translation initiation factor activity				0			OV - Ovarian serous cystadenocarcinoma(20;3.53e-09)|Epithelial(33;4.91e-06)|all cancers(31;1.1e-05)			CTGCAGGTCGGTCTCACGCGT	0.632		NA											17	57					2.94e-08	3.16e-08	1	0
DNM2	1785	broad.mit.edu	37	19	10870479	10870479	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:10870479C>T	uc002mps.1	+	2	391	c.227C>T	c.(226-228)TCA>TTA	p.S76L	DNM2_uc010dxk.2_RNA|DNM2_uc002mpt.1_Missense_Mutation_p.S76L|DNM2_uc002mpv.1_Missense_Mutation_p.S76L|DNM2_uc002mpu.1_Missense_Mutation_p.S76L|DNM2_uc010dxl.1_Missense_Mutation_p.S76L	NM_001005361	NP_001005361	P50570	DYN2_HUMAN	dynamin 2 isoform 2	76					G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			central_nervous_system(2)|skin(2)|ovary(1)|breast(1)	6			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)			CTCATCTTCTCAAAAACAGGT	0.577		NA											33	97					0	0	0	0
YIPF2	78992	broad.mit.edu	37	19	11036435	11036435	+	Silent	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:11036435G>A	uc002mqb.2	-	5	418	c.294C>T	c.(292-294)ATC>ATT	p.I98I	YIPF2_uc002mqc.2_Silent_p.I98I|C19orf52_uc002mqd.1_5'Flank	NM_024029	NP_076934	Q9BWQ6	YIPF2_HUMAN	Yip1 domain family, member 2	98	Cytoplasmic (Potential).					integral to membrane|transport vesicle					0						GTGAGCCTTTGATCCGGTCCA	0.602		NA											8	18					0	0	0	0
ZNF136	7695	broad.mit.edu	37	19	12297854	12297854	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:12297854G>C	uc002mti.2	+	4	761	c.661G>C	c.(661-663)GAG>CAG	p.E221Q	ZNF136_uc010xmh.1_Missense_Mutation_p.E155Q	NM_003437	NP_003428	P52737	ZN136_HUMAN	zinc finger protein 136	221					negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|transcription corepressor activity|zinc ion binding			ovary(1)|pancreas(1)	2						TCACACTGGAGAGAAACCCTA	0.398		NA											17	33					0	0	0	0
ZNF44	51710	broad.mit.edu	37	19	12383859	12383859	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:12383859G>A	uc010xmj.1	-	5	1560	c.1355C>T	c.(1354-1356)TCT>TTT	p.S452F	ZNF44_uc002mtl.2_Intron|ZNF44_uc010dyr.1_Intron|ZNF44_uc010xmi.1_RNA|ZNF44_uc002mtn.3_RNA|ZNF44_uc010dys.2_Missense_Mutation_p.S404F	NM_001164276	NP_001157748	P15621	ZNF44_HUMAN	zinc finger protein 44 isoform 1	452	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton|nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)	1		Renal(1328;0.157)		GBM - Glioblastoma multiforme(1328;0.0164)|Lung(535;0.179)		TACACTAGGAGAATCAAAGGC	0.453		NA											10	42					0	0	0	0
HOOK2	29911	broad.mit.edu	37	19	12883482	12883482	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:12883482C>G	uc002muy.2	-	6	572	c.401G>C	c.(400-402)AGA>ACA	p.R134T	HOOK2_uc002muz.2_Missense_Mutation_p.R134T	NM_013312	NP_037444	Q96ED9	HOOK2_HUMAN	hook homolog 2 isoform 1	134	Sufficient for interaction with microtubules.|Required for localization to the centrosome and induction of aggresome formation.				early endosome to late endosome transport|endocytosis|endosome organization|endosome to lysosome transport|lysosome organization|microtubule cytoskeleton organization|protein transport	centrosome|FHF complex|microtubule	identical protein binding|microtubule binding			ovary(1)|breast(1)|skin(1)	3						CGTCATGATTCTCTGGATGTG	0.582		NA											13	125					0	0	0	0
CACNA1A	773	broad.mit.edu	37	19	13356019	13356019	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:13356019C>T	uc010dze.2	-	31	5166	c.4930G>A	c.(4930-4932)GAT>AAT	p.D1644N	CACNA1A_uc010xnd.1_Missense_Mutation_p.D349N|CACNA1A_uc002mwx.3_Missense_Mutation_p.D349N|CACNA1A_uc010dzc.2_Missense_Mutation_p.D1169N|CACNA1A_uc002mwy.3_Missense_Mutation_p.D1643N|CACNA1A_uc010xne.1_Missense_Mutation_p.D1172N|CACNA1A_uc002mwv.3_Missense_Mutation_p.D160N	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	1644	Helical; Name=S3 of repeat IV; (Potential).|IV.				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	ACGAGGATATCGGTGATGCTG	0.582		NA											18	38					0	0	0	0
MYO9B	4650	broad.mit.edu	37	19	17311114	17311114	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:17311114G>C	uc010eak.2	+	25	4403	c.4251G>C	c.(4249-4251)AAG>AAC	p.K1417N	MYO9B_uc002nfi.2_Missense_Mutation_p.K1417N|MYO9B_uc002nfj.1_Missense_Mutation_p.K1417N|MYO9B_uc002nfl.1_5'UTR	NM_004145	NP_004136	Q13459	MYO9B_HUMAN	myosin IXB isoform 1	1417	Tail.				actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(1)	1						CCACGTTTAAGAGGCTTTTTC	0.502		NA											4	22					0	0	0	0
MAP1S	55201	broad.mit.edu	37	19	17835961	17835961	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:17835961C>T	uc002nhe.1	+	4	416	c.407C>T	c.(406-408)TCG>TTG	p.S136L	MAP1S_uc010eaz.1_RNA|MAP1S_uc010eba.1_Missense_Mutation_p.S136L|MAP1S_uc002nhf.1_Intron|MAP1S_uc010xpv.1_Missense_Mutation_p.S110L	NM_018174	NP_060644	Q66K74	MAP1S_HUMAN	BPY2 interacting protein 1	136	Necessary for the microtubule-organizing center localization.				apoptosis|brain development|microtubule bundle formation|mitochondrion transport along microtubule|neuron projection morphogenesis	cytosol|dendrite|microtubule|neuronal cell body|nucleus|perinuclear region of cytoplasm|spindle|synapse	actin filament binding|beta-tubulin binding|DNA binding|microtubule binding			central_nervous_system(1)	1						GGGGGCTTCTCGCCTCACCAC	0.612		NA											21	63					0	0	0	0
ZNF43	7594	broad.mit.edu	37	19	21992317	21992317	+	Silent	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:21992317G>A	uc002nqj.2	-	4	652	c.522C>T	c.(520-522)TTC>TTT	p.F174F	ZNF43_uc010ecv.2_Silent_p.F168F|ZNF43_uc002nql.2_Silent_p.F168F|ZNF43_uc002nqm.2_Silent_p.F168F|ZNF43_uc002nqk.2_Silent_p.F104F	NM_003423	NP_003414	P17038	ZNF43_HUMAN	zinc finger protein 43	174	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Renal(1328;0.000219)|Hepatocellular(1079;0.121)		GBM - Glioblastoma multiforme(1328;5.97e-05)|STAD - Stomach adenocarcinoma(1328;0.0127)		CTTTGCATTTGAAAAGTTTTT	0.303		NA											11	13					0	0	0	0
ZNF208	7757	broad.mit.edu	37	19	22155770	22155770	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:22155770C>G	uc002nqp.2	-	5	1915	c.1766G>C	c.(1765-1767)GGA>GCA	p.G589A	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				GGGTTTCTCTCCAGTATGAAT	0.383		NA											12	42					0	0	0	0
ZNF345	25850	broad.mit.edu	37	19	37368436	37368436	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:37368436G>C	uc002oex.2	+	3	1082	c.704G>C	c.(703-705)TGT>TCT	p.C235S	ZNF345_uc002oey.3_Missense_Mutation_p.C235S|ZNF345_uc002oez.2_Intron	NM_003419	NP_003410	Q14585	ZN345_HUMAN	zinc finger protein 345	235	C2H2-type 7.				negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TGCAAAGCATGTGGAATGGCC	0.418		NA											19	57					0	0	0	0
DLL3	10683	broad.mit.edu	37	19	39989650	39989650	+	Silent	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:39989650G>A	uc002olx.2	+	1	94	c.36G>A	c.(34-36)CAG>CAA	p.Q12Q	DLL3_uc010egq.2_Silent_p.Q12Q|DLL3_uc002olw.2_Silent_p.Q12Q	NM_016941	NP_058637	Q9NYJ7	DLL3_HUMAN	delta-like 3 protein isoform 1 precursor	12					Notch signaling pathway|skeletal system development	integral to membrane	Notch binding			central_nervous_system(2)|breast(1)	3	all_cancers(60;4.04e-06)|all_lung(34;1.77e-07)|Lung NSC(34;2.09e-07)|all_epithelial(25;1.13e-05)|Ovarian(47;0.159)		Epithelial(26;5.89e-26)|all cancers(26;1.96e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			TCCTCTCCCAGACTGTGATCC	0.617		NA											22	79					0	0	0	0
ERF	2077	broad.mit.edu	37	19	42753748	42753748	+	Silent	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:42753748G>A	uc002ote.3	-	4	674	c.516C>T	c.(514-516)CTC>CTT	p.L172L	ERF_uc002otd.3_5'UTR	NM_006494	NP_006485	P50548	ERF_HUMAN	Ets2 repressor factor	172					cell proliferation|regulation of transcription from RNA polymerase II promoter	nucleus	ligand-regulated transcription factor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			lung(1)|kidney(1)|central_nervous_system(1)|skin(1)	4		Prostate(69;0.00682)				CAGCCGAGAAGAGGGAAGATG	0.657		NA											13	58					0	0	0	0
MEGF8	1954	broad.mit.edu	37	19	42875617	42875617	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:42875617G>C	uc002otl.3	+	40	7686	c.7051G>C	c.(7051-7053)GAC>CAC	p.D2351H	MEGF8_uc002otm.3_Missense_Mutation_p.D1959H|MEGF8_uc002otn.3_Intron	NM_001410	NP_001401	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	2418	Extracellular (Potential).|Laminin EGF-like 4.					integral to membrane	calcium ion binding|structural molecule activity			ovary(1)	1		Prostate(69;0.00682)				TGACCGTCGAGACTGCTACAA	0.627		NA											9	44					0	0	0	0
GYS1	2997	broad.mit.edu	37	19	49477904	49477904	+	Silent	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:49477904G>A	uc002plp.2	-	11	1636	c.1395C>T	c.(1393-1395)CTC>CTT	p.L465L	GYS1_uc010xzy.1_Silent_p.L98L|GYS1_uc010emm.2_Silent_p.L401L|GYS1_uc010xzz.1_Silent_p.L385L|GYS1_uc010yaa.1_RNA	NM_002103	NP_002094	P13807	GYS1_HUMAN	glycogen synthase 1 (muscle) isoform 1	465					glucose metabolic process|glycogen biosynthetic process	cytosol	glycogen (starch) synthase activity|protein binding			ovary(2)	2		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;8.64e-05)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000164)|all cancers(93;0.000226)|GBM - Glioblastoma multiforme(486;0.00561)|Epithelial(262;0.0286)		TGCTATTGAAGAGGCCGATTC	0.617		NA											8	32					0	0	0	0
ZNF175	7728	broad.mit.edu	37	19	52091027	52091027	+	Silent	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:52091027G>A	uc002pxb.2	+	5	1821	c.1443G>A	c.(1441-1443)GGG>GGA	p.G481G		NM_007147	NP_009078	Q9Y473	ZN175_HUMAN	zinc finger protein 175	481	C2H2-type 8.				response to virus	cytoplasm|intermediate filament cytoskeleton|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_neural(266;0.0299)		GBM - Glioblastoma multiforme(134;0.000426)|OV - Ovarian serous cystadenocarcinoma(262;0.0257)		ACAACTGTGGGAAATCCTTCA	0.448		NA											11	19					0	0	0	0
LILRB4	11006	broad.mit.edu	37	19	55179456	55179456	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:55179456C>G	uc002qgp.2	+	12	1695	c.1333C>G	c.(1333-1335)CTG>GTG	p.L445V	LILRB4_uc002qgq.2_Missense_Mutation_p.L444V|LILRB4_uc002qgr.2_Missense_Mutation_p.L487V|LILRB4_uc010ert.2_Missense_Mutation_p.L486V|LILRB4_uc010eru.2_Missense_Mutation_p.L475V	NM_006847	NP_006838	Q8NHJ6	LIRB4_HUMAN	leukocyte immunoglobulin-like receptor,	445	ITIM motif 3.|Cytoplasmic (Potential).					integral to membrane|plasma membrane	antigen binding|receptor activity			ovary(3)	3				GBM - Glioblastoma multiforme(193;0.035)		CTATGCCACTCTGGCCATCCA	0.597		NA											15	59					0	0	0	0
ZNF418	147686	broad.mit.edu	37	19	58439254	58439254	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr19:58439254C>T	uc002qqs.1	-	4	587	c.295G>A	c.(295-297)GAT>AAT	p.D99N	ZNF418_uc010yhn.1_RNA|ZNF418_uc010yho.1_Missense_Mutation_p.D14N	NM_133460	NP_597717	Q8TF45	ZN418_HUMAN	zinc finger protein 418	99	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0158)		CCCTGATGATCTGCCAAGTGC	0.512		NA											21	92					0	0	0	0
KIDINS220	57498	broad.mit.edu	37	2	8871880	8871880	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:8871880G>C	uc002qzc.2	-	30	4468	c.4286C>G	c.(4285-4287)TCA>TGA	p.S1429*	KIDINS220_uc010yiv.1_Intron|KIDINS220_uc002qzd.2_Nonsense_Mutation_p.S1330*|KIDINS220_uc002qzb.2_Nonsense_Mutation_p.S283*	NM_020738	NP_065789	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate of 220 kDa	1429	Cytoplasmic (Potential).				activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				ovary(3)|central_nervous_system(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					CTCTAGGTTTGAATGAATAGA	0.463		NA											29	99					0	0	0	0
NBAS	51594	broad.mit.edu	37	2	15415720	15415720	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:15415720G>A	uc002rcc.1	-	44	5638	c.5612C>T	c.(5611-5613)CCG>CTG	p.P1871L	NBAS_uc010exl.1_Missense_Mutation_p.P943L|NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	1871										ovary(2)|liver(1)|skin(1)	4						AAGCCACTCCGGTGAAGAGCC	0.478		NA											14	50					0	0	0	0
KCNS3	3790	broad.mit.edu	37	2	18113476	18113476	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:18113476C>G	uc002rcv.2	+	3	1652	c.1201C>G	c.(1201-1203)CCC>GCC	p.P401A	KCNS3_uc002rcw.2_Missense_Mutation_p.P401A	NM_002252	NP_002243	Q9BQ31	KCNS3_HUMAN	potassium voltage-gated channel	401	Helical; Name=Segment S6; (Potential).				energy reserve metabolic process|regulation of insulin secretion	Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium channel regulator activity			ovary(4)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					GGTGGCCCTTCCCATCACCAT	0.517		NA											20	48					0	0	0	0
ASXL2	55252	broad.mit.edu	37	2	25965130	25965130	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:25965130G>A	uc002rgs.2	-	12	4297	c.4076C>T	c.(4075-4077)TCA>TTA	p.S1359L	ASXL2_uc002rgt.1_Missense_Mutation_p.S842L	NM_018263	NP_060733	Q76L83	ASXL2_HUMAN	additional sex combs like 2	1359					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CACTGAAAATGACATGACATC	0.493		NA											9	21					0	0	0	0
BIRC6	57448	broad.mit.edu	37	2	32605289	32605289	+	Silent	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:32605289C>T	uc010ezu.2	+	3	710	c.576C>T	c.(574-576)TTC>TTT	p.F192F		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	192					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					ATGATTTGTTCATCACACAGC	0.333		NA											3	10					0	0	0	0
VIT	5212	broad.mit.edu	37	2	37028511	37028511	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:37028511G>C	uc002rpl.2	+	13	1347	c.1126G>C	c.(1126-1128)GAG>CAG	p.E376Q	VIT_uc002rpm.2_Missense_Mutation_p.E354Q|VIT_uc010ezv.2_Missense_Mutation_p.E332Q|VIT_uc010ezw.2_Missense_Mutation_p.E333Q	NM_053276	NP_444506	Q6UXI7	VITRN_HUMAN	vitrin	361	VWFA 1.					proteinaceous extracellular matrix				ovary(1)|pancreas(1)	2		all_hematologic(82;0.248)				GACAGCCATAGAGAAAATTAC	0.393		NA											39	106					0	0	0	0
CCDC88A	55704	broad.mit.edu	37	2	55561259	55561259	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:55561259C>T	uc002ryv.2	-	15	3540	c.2698G>A	c.(2698-2700)GAT>AAT	p.D900N	CCDC88A_uc010yoz.1_Missense_Mutation_p.D900N|CCDC88A_uc010ypa.1_Missense_Mutation_p.D900N|CCDC88A_uc010ypb.1_Missense_Mutation_p.D802N|CCDC88A_uc002ryu.2_Missense_Mutation_p.D183N|CCDC88A_uc002ryw.2_Missense_Mutation_p.D183N	NM_001135597	NP_001129069	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A isoform 1	900	Potential.				activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			ovary(2)|skin(2)	4						GTTTTTATATCAATAGTTGCT	0.279		NA											10	27					0	0	0	0
KIAA1841	84542	broad.mit.edu	37	2	61300626	61300626	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:61300626C>G	uc002saw.3	+	5	674	c.371C>G	c.(370-372)TCT>TGT	p.S124C	KIAA1841_uc002sax.3_Intron|KIAA1841_uc002say.2_Missense_Mutation_p.S124C|KIAA1841_uc002sav.3_Missense_Mutation_p.S124C	NM_001129993	NP_001123465	Q6NSI8	K1841_HUMAN	KIAA1841 protein isoform a	124											0			Epithelial(17;0.193)			AGGAATTGTTCTTCAGAAAGT	0.353		NA											10	35					0	0	0	0
ARHGAP25	9938	broad.mit.edu	37	2	69045102	69045102	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:69045102G>A	uc002seu.2	+	8	1340	c.976G>A	c.(976-978)GAA>AAA	p.E326K	ARHGAP25_uc010fdg.2_Missense_Mutation_p.E327K|ARHGAP25_uc010yql.1_Missense_Mutation_p.E287K|ARHGAP25_uc002sev.2_Missense_Mutation_p.E320K|ARHGAP25_uc002sew.2_Missense_Mutation_p.E319K|ARHGAP25_uc002sex.2_Missense_Mutation_p.E320K|ARHGAP25_uc010fdh.1_RNA|ARHGAP25_uc002sey.2_Missense_Mutation_p.E53K	NM_001007231	NP_001007232	P42331	RHG25_HUMAN	Rho GTPase activating protein 25 isoform a	326	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|breast(2)	4						GTCGAAGGTCGAAGACCCTGC	0.418		NA											15	36					0	0	0	0
HTRA2	27429	broad.mit.edu	37	2	74757145	74757145	+	Silent	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:74757145G>A	uc002smi.1	+	1	614	c.12G>A	c.(10-12)CCG>CCA	p.P4P	AUP1_uc002sme.2_5'Flank|AUP1_uc002smf.2_5'Flank|AUP1_uc002smg.2_5'Flank|AUP1_uc002smh.2_5'Flank|AUP1_uc010yrx.1_5'Flank|AUP1_uc010yry.1_5'Flank|HTRA2_uc002smj.1_Silent_p.P4P|HTRA2_uc002smk.1_Silent_p.P4P|HTRA2_uc002sml.1_Silent_p.P4P|HTRA2_uc002smm.1_Intron|HTRA2_uc002smn.1_Intron|HTRA2_uc010ffl.2_5'Flank	NM_013247	NP_037379	O43464	HTRA2_HUMAN	HtrA serine peptidase 2 isoform 1 preproprotein	4					apoptosis|proteolysis|response to stress	CD40 receptor complex|endoplasmic reticulum membrane|internal side of plasma membrane|mitochondrial intermembrane space|mitochondrial membrane|nucleus	serine-type endopeptidase activity|unfolded protein binding			ovary(1)	1						TGGCTGCGCCGAGGGCGGGGC	0.741		NA											8	33					0	0	0	0
HTRA2	27429	broad.mit.edu	37	2	74757169	74757169	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:74757169G>C	uc002smi.1	+	1	638	c.36G>C	c.(34-36)TGG>TGC	p.W12C	AUP1_uc002sme.2_5'Flank|AUP1_uc002smf.2_5'Flank|AUP1_uc002smg.2_5'Flank|AUP1_uc002smh.2_5'Flank|AUP1_uc010yrx.1_5'Flank|AUP1_uc010yry.1_5'Flank|HTRA2_uc002smj.1_Missense_Mutation_p.W12C|HTRA2_uc002smk.1_Missense_Mutation_p.W12C|HTRA2_uc002sml.1_Missense_Mutation_p.W12C|HTRA2_uc002smm.1_Intron|HTRA2_uc002smn.1_Intron|HTRA2_uc010ffl.2_5'Flank	NM_013247	NP_037379	O43464	HTRA2_HUMAN	HtrA serine peptidase 2 isoform 1 preproprotein	12					apoptosis|proteolysis|response to stress	CD40 receptor complex|endoplasmic reticulum membrane|internal side of plasma membrane|mitochondrial intermembrane space|mitochondrial membrane|nucleus	serine-type endopeptidase activity|unfolded protein binding			ovary(1)	1						GTGCAGGCTGGAGCCTTCGGG	0.716		NA											10	39					0	0	0	0
HK2	3099	broad.mit.edu	37	2	75100416	75100416	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:75100416C>G	uc002snd.2	+	5	2435	c.509C>G	c.(508-510)TCA>TGA	p.S170*		NM_000189	NP_000180	P52789	HXK2_HUMAN	hexokinase 2	170	Regulatory.				apoptotic mitochondrial changes|glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane	ATP binding|glucokinase activity			ovary(1)|lung(1)	2						TTCCTGGTCTCATGGACCAAG	0.522		NA											17	94					0	0	0	0
TMEM131	23505	broad.mit.edu	37	2	98409038	98409038	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:98409038C>G	uc002syh.3	-	31	4184	c.3955G>C	c.(3955-3957)GAA>CAA	p.E1319Q		NM_015348	NP_056163	Q92545	TM131_HUMAN	RW1 protein	1319	Pro-rich.					integral to membrane				ovary(4)|central_nervous_system(2)	6						GACAGCCTTTCAGGCTGCGGC	0.677		NA											6	9					0	0	0	0
CHST10	9486	broad.mit.edu	37	2	101010229	101010229	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:101010229G>C	uc002tam.2	-	7	908	c.549C>G	c.(547-549)TTC>TTG	p.F183L		NM_004854	NP_004845	O43529	CHSTA_HUMAN	HNK-1 sulfotransferase	183	Lumenal (Potential).				carbohydrate biosynthetic process|cell adhesion	Golgi membrane|integral to membrane|membrane fraction				ovary(1)	1						TAAAAAACTTGAAGTATGTTT	0.423		NA											13	37					0	0	0	0
SMPD4	55627	broad.mit.edu	37	2	130911298	130911298	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:130911298C>T	uc002tqq.1	-	17	2507	c.1987G>A	c.(1987-1989)GAG>AAG	p.E663K	SMPD4_uc002tqo.1_Missense_Mutation_p.E195K|SMPD4_uc002tqp.1_Missense_Mutation_p.E402K|SMPD4_uc010yzy.1_Missense_Mutation_p.E412K|SMPD4_uc010yzz.1_Missense_Mutation_p.E327K|SMPD4_uc002tqr.1_Missense_Mutation_p.E634K|SMPD4_uc002tqs.1_Missense_Mutation_p.E531K|SMPD4_uc002tqt.1_Missense_Mutation_p.E512K|SMPD4_uc010zaa.1_Missense_Mutation_p.E521K|SMPD4_uc010zab.1_Missense_Mutation_p.E561K|SMPD4_uc010zac.1_Missense_Mutation_p.E404K|SMPD4_uc010zad.1_Missense_Mutation_p.E299K	NM_017951	NP_060421	Q9NXE4	NSMA3_HUMAN	sphingomyelin phosphodiesterase 4 isoform 2	624					sphingomyelin catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|trans-Golgi network	metal ion binding|protein binding|sphingomyelin phosphodiesterase activity|sphingomyelin phosphodiesterase D activity				0	Colorectal(110;0.1)				Phosphatidylserine(DB00144)	CGCAGGTACTCCAGGGCCTTC	0.597		NA											6	45					0	0	0	0
LRP1B	53353	broad.mit.edu	37	2	141259290	141259290	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:141259290G>A	uc002tvj.1	-	55	9788	c.8816C>T	c.(8815-8817)TCT>TTT	p.S2939F		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2939	Extracellular (Potential).|EGF-like 6.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ACAGTCTTGAGAACATCCACT	0.388		NA								TSP Lung(27;0.18)			12	79					0	0	0	0
CSRNP3	80034	broad.mit.edu	37	2	166533010	166533010	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:166533010G>T	uc002udf.2	+	6	973	c.597G>T	c.(595-597)AAG>AAT	p.K199N	CSRNP3_uc002udg.2_Missense_Mutation_p.K199N	NM_024969	NP_079245	Q8WYN3	CSRN3_HUMAN	cysteine-serine-rich nuclear protein 3	199					apoptosis|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|large_intestine(1)|skin(1)	5						TGGAAGAAAAGCACGAACTCC	0.522		NA											30	78					1.25e-16	1.36e-16	1	0
HOXD10	3236	broad.mit.edu	37	2	176982029	176982029	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:176982029G>C	uc002ukj.2	+	1	538	c.468G>C	c.(466-468)CAG>CAC	p.Q156H		NM_002148	NP_002139	P28358	HXD10_HUMAN	homeobox D10	156						nucleus	sequence-specific DNA binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	Colorectal(32;0.0226)|READ - Rectum adenocarcinoma(9;0.0556)		GACTGAGTCAGACCTACGCCA	0.582		NA											16	107					0	0	0	0
STAT1	6772	broad.mit.edu	37	2	191859795	191859795	+	Silent	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:191859795G>C	uc002usj.2	-	10	1324	c.936C>G	c.(934-936)CTC>CTG	p.L312L	STAT1_uc010fse.1_Silent_p.L312L|STAT1_uc002usk.2_Silent_p.L312L|STAT1_uc002usl.2_Silent_p.L314L|STAT1_uc010fsf.1_Silent_p.L124L	NM_007315	NP_009330	P42224	STAT1_HUMAN	signal transducer and activator of transcription	312					activation of caspase activity|I-kappaB kinase/NF-kappaB cascade|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway|tyrosine phosphorylation of STAT protein	cytosol|nucleolus|nucleoplasm	calcium ion binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|signal transducer activity			lung(3)|breast(3)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.00434)|Epithelial(96;0.0555)|all cancers(119;0.141)		Fludarabine(DB01073)	ACCTCTGAATGAGCTGCTGGA	0.388		NA											7	44					0	0	0	0
STAT1	6772	broad.mit.edu	37	2	191859849	191859849	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:191859849G>C	uc002usj.2	-	10	1270	c.882C>G	c.(880-882)ATC>ATG	p.I294M	STAT1_uc010fse.1_Missense_Mutation_p.I294M|STAT1_uc002usk.2_Missense_Mutation_p.I294M|STAT1_uc002usl.2_Missense_Mutation_p.I296M|STAT1_uc010fsf.1_Missense_Mutation_p.I106M	NM_007315	NP_009330	P42224	STAT1_HUMAN	signal transducer and activator of transcription	294					activation of caspase activity|I-kappaB kinase/NF-kappaB cascade|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway|tyrosine phosphorylation of STAT protein	cytosol|nucleolus|nucleoplasm	calcium ion binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|signal transducer activity			lung(3)|breast(3)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.00434)|Epithelial(96;0.0555)|all cancers(119;0.141)		Fludarabine(DB01073)	TGTTTTTTGTGATAGGGTCAT	0.438		NA											7	49					0	0	0	0
NBEAL1	65065	broad.mit.edu	37	2	204000956	204000956	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:204000956C>G	uc002uzt.3	+	27	4616	c.4283C>G	c.(4282-4284)TCT>TGT	p.S1428C	NBEAL1_uc002uzs.3_Missense_Mutation_p.S138C	NM_001114132	NP_001107604	Q6ZS30	NBEL1_HUMAN	neurobeachin-like 1 isoform 3	1428							binding			ovary(1)|skin(1)	2						GATGACTTCTCTTTACTTGAA	0.363		NA											11	40					0	0	0	0
GLB1L	79411	broad.mit.edu	37	2	220102389	220102389	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:220102389G>C	uc002vkm.2	-	16	1773	c.1534C>G	c.(1534-1536)CTG>GTG	p.L512V	GLB1L_uc002vkk.2_Missense_Mutation_p.L269V|GLB1L_uc010zkx.1_Missense_Mutation_p.L422V|GLB1L_uc002vkn.2_Missense_Mutation_p.L512V	NM_024506	NP_078782	Q6UWU2	GLB1L_HUMAN	galactosidase, beta 1-like precursor	512					carbohydrate metabolic process	extracellular region	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds				0		all_lung(227;1.19e-05)|Lung NSC(271;2.76e-05)|Medulloblastoma(418;0.0208)|Esophageal squamous(248;0.0559)		Epithelial(149;1.3e-11)|all cancers(144;2.07e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TCAATTTTCAGAGGGAACATC	0.453		NA											19	46					0	0	0	0
STK16	8576	broad.mit.edu	37	2	220111834	220111834	+	Splice_Site	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:220111834G>C	uc002vko.2	+	4	464	c.307_splice	c.e4-1	p.R103_splice	GLB1L_uc002vkm.2_5'Flank|GLB1L_uc002vkn.2_5'Flank|STK16_uc002vks.2_Intron|STK16_uc010zky.1_Splice_Site_p.R103_splice|STK16_uc010fwf.2_Splice_Site_p.R103_splice|STK16_uc002vkp.2_Splice_Site_p.R103_splice|STK16_uc002vkr.2_Splice_Site_p.R36_splice|STK16_uc002vkq.2_Splice_Site_p.R148_splice	NM_001008910	NP_001008910	O75716	STK16_HUMAN	serine/threonine kinase 16						protein complex assembly	membrane	ATP binding|protein binding|protein serine/threonine kinase activity			skin(1)	1		Renal(207;0.0474)		Epithelial(149;1.2e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TTGTGTTGCAGAGAGGTACGC	0.502		NA											9	21					0	0	0	0
IRS1	3667	broad.mit.edu	37	2	227660640	227660640	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:227660640C>T	uc002voh.3	-	1	2867	c.2815G>A	c.(2815-2817)GAG>AAG	p.E939K		NM_005544	NP_005535	P35568	IRS1_HUMAN	insulin receptor substrate 1	939					fibroblast growth factor receptor signaling pathway|glucose homeostasis|insulin receptor signaling pathway|negative regulation of insulin receptor signaling pathway|negative regulation of insulin secretion|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity	caveola|cytosol|insulin receptor complex|microsome|nucleus	insulin receptor binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase binding|protein kinase C binding|SH2 domain binding|transmembrane receptor protein tyrosine kinase adaptor activity			lung(5)|central_nervous_system(4)|ovary(2)|pancreas(1)	12		Renal(207;0.023)|all_lung(227;0.0994)|all_hematologic(139;0.118)|Esophageal squamous(248;0.23)		Epithelial(121;3.03e-11)|all cancers(144;2.42e-08)|Lung(261;0.00712)|LUSC - Lung squamous cell carcinoma(224;0.0137)		ATGTACTCCTCAGTGCCAGTC	0.652		NA											19	82					0	0	0	0
GIGYF2	26058	broad.mit.edu	37	2	233710554	233710554	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:233710554G>A	uc002vti.3	+	28	3755	c.3418G>A	c.(3418-3420)GAA>AAA	p.E1140K	GIGYF2_uc002vtj.3_Missense_Mutation_p.E1161K|GIGYF2_uc002vtk.3_Missense_Mutation_p.E1140K|GIGYF2_uc002vth.3_Missense_Mutation_p.E1134K|GIGYF2_uc010zmk.1_Intron|GIGYF2_uc002vtq.3_Missense_Mutation_p.E473K	NM_015575	NP_056390	Q6Y7W6	PERQ2_HUMAN	GRB10 interacting GYF protein 2 isoform b	1140					cell death		protein binding			ovary(4)|central_nervous_system(3)	7		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		GCAGTGGTGTGAACAGATGCT	0.274		NA											11	40					0	0	0	0
INPP5D	3635	broad.mit.edu	37	2	234104054	234104054	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:234104054A>G	uc010zmo.1	+	23	2759	c.2606A>G	c.(2605-2607)AAG>AGG	p.K869R	INPP5D_uc010zmp.1_Missense_Mutation_p.K868R	NM_001017915	NP_001017915	Q92835	SHIP1_HUMAN	SH2 containing inositol phosphatase isoform a	869					apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			ovary(1)|central_nervous_system(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		GACTTTGTGAAGACGGAGCGT	0.473		NA											15	50					0	0	0	0
TRPM8	79054	broad.mit.edu	37	2	234888876	234888876	+	Silent	SNP	G	G	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:234888876G>T	uc002vvh.2	+	18	2440	c.2400G>T	c.(2398-2400)GTG>GTT	p.V800V	TRPM8_uc010fyj.2_Silent_p.V378V|TRPM8_uc010fyk.2_5'Flank	NM_024080	NP_076985	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel,	800	Helical; Name=4; (Potential).					integral to membrane				skin(4)	4		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	TGTGGAATGTGATGGACACGC	0.408		NA											6	25					0.00198382	0.00204096	1	0
HDLBP	3069	broad.mit.edu	37	2	242194963	242194963	+	Silent	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr2:242194963C>G	uc002waz.2	-	8	1134	c.906G>C	c.(904-906)GTG>GTC	p.V302V	HDLBP_uc002wba.2_Silent_p.V302V|HDLBP_uc002wbb.2_Intron|HDLBP_uc010fzn.1_Intron	NM_203346	NP_976221	Q00341	VIGLN_HUMAN	high density lipoprotein binding protein	302	KH 2.				cholesterol metabolic process|lipid transport	cytoplasm|high-density lipoprotein particle|nucleus|plasma membrane	lipid binding|protein binding|RNA binding			breast(3)|skin(1)	4		all_cancers(19;7.77e-41)|all_epithelial(40;1.74e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.0121)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;8.13e-34)|all cancers(36;4.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;2.34e-15)|Kidney(56;3.72e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.76e-08)|BRCA - Breast invasive adenocarcinoma(100;3.38e-06)|Lung(119;0.000109)|LUSC - Lung squamous cell carcinoma(224;0.000964)|Colorectal(34;0.0132)|COAD - Colon adenocarcinoma(134;0.0928)		GGGATTTCTTCACTTCCACTG	0.493		NA											20	74					0	0	0	0
SIRPB1	10326	broad.mit.edu	37	20	1559329	1559329	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr20:1559329C>G	uc010gai.2	-	2	187	c.88G>C	c.(88-90)GAG>CAG	p.E30Q	SIRPB1_uc002wfk.3_Missense_Mutation_p.E30Q	NM_006065	NP_006056	O00241	SIRB1_HUMAN	signal-regulatory protein beta 1 isoform 1	30	Extracellular (Potential).|Ig-like V-type.				cell junction assembly|cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding			ovary(1)	1						AGCTCGTCCTCACCTGCCACT	0.507		NA											7	93					0	0	0	0
XKR7	343702	broad.mit.edu	37	20	30584822	30584822	+	Silent	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr20:30584822C>G	uc002wxe.2	+	3	1476	c.1302C>G	c.(1300-1302)GTC>GTG	p.V434V		NM_001011718	NP_001011718	Q5GH72	XKR7_HUMAN	XK, Kell blood group complex subunit-related	434	Helical; (Potential).					integral to membrane				ovary(1)|breast(1)|skin(1)	3			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			TCATGTGTGTCTACTACTGTC	0.587		NA											15	46					0	0	0	0
ASXL1	171023	broad.mit.edu	37	20	31022345	31022345	+	Silent	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr20:31022345C>T	uc002wxs.2	+	12	2256	c.1830C>T	c.(1828-1830)GGC>GGT	p.G610G	ASXL1_uc010geb.2_Silent_p.G501G	NM_015338	NP_056153	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 isoform 1	610					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding	p.Q592fs*5(1)|p.G610G(1)		haematopoietic_and_lymphoid_tissue(239)|large_intestine(6)|central_nervous_system(2)|ovary(1)	248						GTTGGACTGGCGCCAGGACCC	0.632		NA	F|N|Mis		MDS|CMML								8	31					0	0	0	0
RPN2	6185	broad.mit.edu	37	20	35827507	35827508	+	Missense_Mutation	DNP	TC	TC	AA			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr20:35827507_35827508TC>AA	uc002xgp.2	+	4	662_663	c.358_359TC>AA	c.(358-360)TCA>AAA	p.S120K	RPN2_uc002xgo.3_Missense_Mutation_p.S120K|RPN2_uc010gfw.2_Intron|RPN2_uc002xgq.2_Missense_Mutation_p.S88K	NM_002951	NP_002942	P04844	RPN2_HUMAN	ribophorin II isoform 1 precursor	120	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|nucleus|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding			ovary(2)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				CAGTGAGGACTCATCTGTTACC	0.48		NA											22	69					0	0	0	0
HNF4A	3172	broad.mit.edu	37	20	43047076	43047076	+	Silent	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr20:43047076C>T	uc002xma.2	+	6	749	c.660C>T	c.(658-660)CTC>CTT	p.L220L	HNF4A_uc002xlt.2_Silent_p.L198L|HNF4A_uc002xlu.2_Silent_p.L198L|HNF4A_uc002xlv.2_Silent_p.L198L|HNF4A_uc002xly.2_Silent_p.L220L|HNF4A_uc002xlz.2_Silent_p.L220L|HNF4A_uc010ggq.2_Silent_p.L213L	NM_000457	NP_000448	P41235	HNF4A_HUMAN	hepatocyte nuclear factor 4 alpha isoform b	220					blood coagulation|endocrine pancreas development|glucose homeostasis|negative regulation of cell growth|negative regulation of cell proliferation|ornithine metabolic process|phospholipid homeostasis|positive regulation of cholesterol homeostasis|regulation of growth hormone receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to glucose stimulus|triglyceride homeostasis|xenobiotic metabolic process	cytoplasm	activating transcription factor binding|protein homodimerization activity|receptor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|lung(1)|skin(1)	3		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			TGGCCCTGCTCAGAGCCCATG	0.483		NA											25	84					0	0	0	0
KCNK15	60598	broad.mit.edu	37	20	43379022	43379022	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr20:43379022C>G	uc002xmr.2	+	2	600	c.536C>G	c.(535-537)TCG>TGG	p.S179W		NM_022358	NP_071753	Q9H427	KCNKF_HUMAN	potassium family, subfamily K, member 15	179	Helical; (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity				0		Myeloproliferative disorder(115;0.0122)				GTCGCCTTCTCGCACTTCGAG	0.677		NA											4	19					0	0	0	0
ARFGEF2	10564	broad.mit.edu	37	20	47582443	47582443	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr20:47582443G>C	uc002xtx.3	+	8	1094	c.942G>C	c.(940-942)GAG>GAC	p.E314D		NM_006420	NP_006411	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine	314					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(3)|upper_aerodigestive_tract(1)	4			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			CAGAACCTGAGAGAGTTCTAG	0.473		NA											14	67					0	0	0	0
ADNP	23394	broad.mit.edu	37	20	49510683	49510683	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr20:49510683G>C	uc002xvt.1	-	5	913	c.568C>G	c.(568-570)CAG>GAG	p.Q190E	ADNP_uc002xvu.1_Missense_Mutation_p.Q190E	NM_015339	NP_056154	Q9H2P0	ADNP_HUMAN	activity-dependent neuroprotector	190						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2						GCCACATGCTGAAAATGTTCC	0.448		NA											24	82					0	0	0	0
NFATC2	4773	broad.mit.edu	37	20	50049030	50049030	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr20:50049030G>A	uc002xwd.2	-	9	2516	c.2296C>T	c.(2296-2298)CAG>TAG	p.Q766*	NFATC2_uc002xwc.2_Nonsense_Mutation_p.Q766*|NFATC2_uc010zyv.1_Nonsense_Mutation_p.Q547*|NFATC2_uc010zyw.1_Nonsense_Mutation_p.Q547*|NFATC2_uc010zyx.1_Nonsense_Mutation_p.Q746*|NFATC2_uc010zyy.1_Nonsense_Mutation_p.Q547*|NFATC2_uc010zyz.1_Nonsense_Mutation_p.Q547*|NFATC2_uc002xwe.2_Nonsense_Mutation_p.Q746*	NM_173091	NP_775114	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells,	766					B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Hepatocellular(150;0.248)					GCCGGCTGCTGATAGCCCAGC	0.697		NA											5	18					0	0	0	0
LIPI	149998	broad.mit.edu	37	21	15561416	15561416	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr21:15561416C>G	uc002yjm.2	-	2	444	c.434G>C	c.(433-435)AGA>ACA	p.R145T	LIPI_uc010gkw.1_Missense_Mutation_p.R78T	NM_198996	NP_945347	Q6XZB0	LIPI_HUMAN	lipase, member I	124					lipid catabolic process	extracellular region|extracellular space|membrane|plasma membrane	heparin binding|phospholipase activity			ovary(2)	2				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.0015)|Colorectal(24;0.00693)|Lung(58;0.166)		TTTAACTGCTCTATTATAAAT	0.338		NA											5	43					0	0	0	0
SUMO3	6612	broad.mit.edu	37	21	46226908	46226908	+	Silent	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr21:46226908C>T	uc002zfz.1	-	4	431	c.270G>A	c.(268-270)ACG>ACA	p.T90T	SUMO3_uc011afi.1_Silent_p.T128T|SUMO3_uc002zga.1_Missense_Mutation_p.R107Q	NM_006936	NP_008867	P55854	SUMO3_HUMAN	small ubiquitin-like modifier protein 3	90	Ubiquitin-like.				protein sumoylation	cytoplasm|kinetochore	protein binding				0				Colorectal(79;0.058)		GCACACCTCCCGTCTGCTGCT	0.612		NA											10	35					0	0	0	0
COL6A2	1292	broad.mit.edu	37	21	47546045	47546045	+	Silent	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr21:47546045C>G	uc002zia.1	+	26	2398	c.2316C>G	c.(2314-2316)CTC>CTG	p.L772L	COL6A2_uc002zhy.1_Silent_p.L772L|COL6A2_uc002zhz.1_Silent_p.L772L|COL6A2_uc002zib.1_Silent_p.L178L|COL6A2_uc002zic.1_5'Flank	NM_001849	NP_001840	P12110	CO6A2_HUMAN	alpha 2 type VI collagen isoform 2C2 precursor	772	VWFA 2.|Nonhelical region.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(7)|ovary(1)	8	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		GTGAAAACCTCTACTCCATCG	0.587		NA											48	143					0	0	0	0
PI4KA	5297	broad.mit.edu	37	22	21104247	21104247	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr22:21104247C>T	uc002zsz.3	-	28	3246	c.3015G>A	c.(3013-3015)ATG>ATA	p.M1005I		NM_058004	NP_477352	P42356	PI4KA_HUMAN	phosphatidylinositol 4-kinase type 3 alpha	1005					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|synaptic transmission	Golgi-associated vesicle	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			lung(2)|upper_aerodigestive_tract(1)|salivary_gland(1)	4	all_cancers(11;7.59e-25)|all_epithelial(7;1.34e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)			CCTGGAGGATCATCCCACAGC	0.527		NA											8	30					0	0	0	0
RAB36	9609	broad.mit.edu	37	22	23495243	23495243	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr22:23495243G>A	uc002zwv.1	+	5	489	c.449G>A	c.(448-450)CGA>CAA	p.R150Q	RAB36_uc010gtw.1_Missense_Mutation_p.R128Q	NM_004914	NP_004905	O95755	RAB36_HUMAN	RAB36, member RAS oncogene family	150					protein transport|small GTPase mediated signal transduction	Golgi membrane	GTP binding			ovary(1)|central_nervous_system(1)	2	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.155)		GTTTTTGATCGAGACTACAAG	0.493		NA											23	97					0	0	0	0
CYTSA	23384	broad.mit.edu	37	22	24759250	24759250	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr22:24759250C>T	uc002zzw.2	+	12	3072	c.2765C>T	c.(2764-2766)TCA>TTA	p.S922L	CYTSA_uc002zzv.3_Missense_Mutation_p.S922L|CYTSA_uc011ajq.1_Missense_Mutation_p.S922L	NM_015330	NP_056145	Q69YQ0	CYTSA_HUMAN	cytospin A	922					cell cycle|cell division						0						AGAACATCTTCAGCCAGCCGG	0.403		NA											13	28					0	0	0	0
OSM	5008	broad.mit.edu	37	22	30660370	30660370	+	Silent	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr22:30660370C>T	uc003ahb.2	-	3	313	c.261G>A	c.(259-261)CTG>CTA	p.L87L		NM_020530	NP_065391	P13725	ONCM_HUMAN	oncostatin M precursor	87					cell proliferation|immune response|negative regulation of cell proliferation|negative regulation of hormone secretion|positive regulation of cell division|positive regulation of cell proliferation|positive regulation of MAPKKK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of transcription from RNA polymerase II promoter|regulation of growth	extracellular space|oncostatin-M receptor complex	cytokine activity|growth factor activity|oncostatin-M receptor binding			skin(1)	1			Epithelial(10;0.206)			CCAGCCCCCTCAGGGTCTCCT	0.657		NA											8	18					0	0	0	0
APOL1	8542	broad.mit.edu	37	22	36661869	36661869	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr22:36661869G>C	uc003apf.2	+	6	1155	c.987G>C	c.(985-987)ATG>ATC	p.M329I	APOL1_uc011amn.1_Missense_Mutation_p.M206I|APOL1_uc003apc.2_RNA|APOL1_uc003ape.2_Missense_Mutation_p.M345I|APOL1_uc011amo.1_Missense_Mutation_p.M206I|APOL1_uc011amp.1_Missense_Mutation_p.M329I|APOL1_uc011amq.1_Missense_Mutation_p.M311I|APOL1_uc010gwx.2_Missense_Mutation_p.M206I	NM_003661	NP_003652	O14791	APOL1_HUMAN	apolipoprotein L1 isoform a precursor	329					cholesterol metabolic process|cytolysis|innate immune response|killing of cells of other organism|lipid transport|lipoprotein metabolic process	high-density lipoprotein particle|very-low-density lipoprotein particle	chloride channel activity|lipid binding|protein binding			breast(2)|ovary(1)	3						TCCTGGAAATGAGCAGAGGAG	0.542		NA											6	47					0	0	0	0
EP300	2033	broad.mit.edu	37	22	41565529	41565529	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr22:41565529G>A	uc003azl.3	+	26	4590	c.4195G>A	c.(4195-4197)GAT>AAT	p.D1399N		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1399				D->Y: Does not interact with TFAP2A and inhibits transcriptional coactivation of TFAP2A by CITED2. Does not inhibit interaction with CITED2, DNA-binding of TFAP2A or nuclear localization of TFAP2A or CITED2.	apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding	p.D1399Y(1)		haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						ATCTTACCTCGATAGTGTTCA	0.338		NA	T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				13	55					0	0	0	0
PIM3	415116	broad.mit.edu	37	22	50356510	50356510	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr22:50356510C>T	uc003bjb.2	+	5	1243	c.790C>T	c.(790-792)CCA>TCA	p.P264S	PIM3_uc011arj.1_Missense_Mutation_p.P27S	NM_001001852	NP_001001852	Q86V86	PIM3_HUMAN	serine/threonine protein kinase pim-3	264	Protein kinase.				cell cycle|negative regulation of apoptosis|regulation of mitotic cell cycle		ATP binding|protein binding|protein serine/threonine kinase activity				0		all_cancers(38;5.53e-07)|all_epithelial(38;3.84e-06)|all_lung(38;0.00208)|Breast(42;0.0104)|Lung NSC(38;0.0199)|Ovarian(80;0.0907)|Lung SC(80;0.236)		BRCA - Breast invasive adenocarcinoma(115;0.196)|LUAD - Lung adenocarcinoma(64;0.247)		GAGGGTCTCTCCAGGTGCGTG	0.682		NA											8	25					0	0	0	0
TUBGCP6	85378	broad.mit.edu	37	22	50656779	50656779	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr22:50656779G>C	uc003bkb.1	-	23	5519	c.5007C>G	c.(5005-5007)TTC>TTG	p.F1669L	TUBGCP6_uc003bka.1_Missense_Mutation_p.Q746E|TUBGCP6_uc010har.1_Missense_Mutation_p.F1661L|TUBGCP6_uc010has.1_RNA	NM_020461	NP_065194	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	1669					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			ovary(2)|central_nervous_system(2)	4		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		TCTCGTGCTTGAACAGCTGCA	0.632		NA											12	36					0	0	0	0
PLXNB2	23654	broad.mit.edu	37	22	50724643	50724643	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr22:50724643G>C	uc003bkv.3	-	9	1942	c.1836C>G	c.(1834-1836)TTC>TTG	p.F612L		NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	612	Extracellular (Potential).				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GGCAGTCGTAGAAGGGGTACT	0.627		NA											28	79					0	0	0	0
LRRN1	57633	broad.mit.edu	37	3	3887186	3887186	+	Silent	SNP	T	T	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:3887186T>C	uc003bpt.3	+	2	1622	c.861T>C	c.(859-861)CTT>CTC	p.L287L	SUMF1_uc003bps.1_Intron	NM_020873	NP_065924	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1 precursor	287	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		AAAATATGCTTCGGTTAAAAG	0.438		NA											16	69					0	0	0	0
RAD18	56852	broad.mit.edu	37	3	8940660	8940660	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:8940660C>A	uc003brd.2	-	11	1317	c.1240G>T	c.(1240-1242)GAA>TAA	p.E414*	RAD18_uc003bre.2_RNA	NM_020165	NP_064550	Q9NS91	RAD18_HUMAN	postreplication repair protein hRAD18p	414					DNA repair	nucleus|replication fork	damaged DNA binding|ligase activity|ubiquitin protein ligase binding|Y-form DNA binding|zinc ion binding			skin(3)|ovary(2)	5				OV - Ovarian serous cystadenocarcinoma(96;0.0552)		CTGTCAGGTTCCAATTCCTCT	0.368		NA						Rad6_pathway					9	31					1.77e-08	1.9e-08	1	0
IRAK2	3656	broad.mit.edu	37	3	10264469	10264469	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:10264469G>A	uc003bve.1	+	9	1239	c.1163G>A	c.(1162-1164)CGG>CAG	p.R388Q		NM_001570	NP_001561	O43187	IRAK2_HUMAN	interleukin-1 receptor-associated kinase 2	388	Protein kinase.				activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|interleukin-1-mediated signaling pathway|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of NF-kappaB transcription factor activity|positive regulation of NF-kappaB transcription factor activity|regulation of cytokine-mediated signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|endosome membrane|plasma membrane	ATP binding|NF-kappaB-inducing kinase activity|protein heterodimerization activity|protein homodimerization activity			lung(5)|breast(3)	8						GATTTCATCCGGGTGGGGCAG	0.527		NA											22	72					0	0	0	0
C3orf19	51244	broad.mit.edu	37	3	14706577	14706577	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:14706577G>A	uc003byw.2	+	6	619	c.528G>A	c.(526-528)ATG>ATA	p.M176I	C3orf19_uc010hei.1_Missense_Mutation_p.M176I|C3orf19_uc010hej.2_Missense_Mutation_p.M81I	NM_016474	NP_057558	Q6PII3	CC019_HUMAN	hypothetical protein LOC51244	176											0						GGCGCTGTATGAGAAAGGATT	0.473		NA											11	125					0	0	0	0
NR1D2	9975	broad.mit.edu	37	3	24003755	24003755	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:24003755C>G	uc003ccs.2	+	5	1124	c.805C>G	c.(805-807)CAA>GAA	p.Q269E	NR1D2_uc010hfd.2_RNA|NR1D2_uc011awk.1_Missense_Mutation_p.Q194E	NM_005126	NP_005117	Q14995	NR1D2_HUMAN	nuclear receptor subfamily 1, group D, member 2	269					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			urinary_tract(1)|kidney(1)|skin(1)	3						TATGTATAATCAAGAGCAGCA	0.423		NA											12	39					0	0	0	0
NR1D2	9975	broad.mit.edu	37	3	24003916	24003916	+	Silent	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:24003916C>T	uc003ccs.2	+	5	1285	c.966C>T	c.(964-966)TTC>TTT	p.F322F	NR1D2_uc010hfd.2_RNA|NR1D2_uc011awk.1_Silent_p.F247F	NM_005126	NP_005117	Q14995	NR1D2_HUMAN	nuclear receptor subfamily 1, group D, member 2	322					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			urinary_tract(1)|kidney(1)|skin(1)	3						ATGGACAGTTCAAAGGGAGGA	0.398		NA											9	28					0	0	0	0
MYRIP	25924	broad.mit.edu	37	3	40223839	40223839	+	Silent	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:40223839G>A	uc003cka.2	+	9	1137	c.1002G>A	c.(1000-1002)AAG>AAA	p.K334K	MYRIP_uc010hhu.2_RNA|MYRIP_uc010hhv.2_Silent_p.K334K|MYRIP_uc010hhw.2_Silent_p.K245K|MYRIP_uc011ayz.1_Silent_p.K147K|uc003ckb.2_Intron	NM_015460	NP_056275	Q8NFW9	MYRIP_HUMAN	myosin VIIA and Rab interacting protein	334	Myosin-binding.				intracellular protein transport		actin binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.174)|Kidney(284;0.206)		CCAGCTGGAAGAGTGTGGACA	0.522		NA											9	29					0	0	0	0
PTPN23	25930	broad.mit.edu	37	3	47448093	47448093	+	Silent	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:47448093C>G	uc003crf.1	+	8	846	c.750C>G	c.(748-750)GCC>GCG	p.A250A	PTPN23_uc011baw.1_Silent_p.A215A|PTPN23_uc011bax.1_RNA|PTPN23_uc011bay.1_Silent_p.A120A	NM_015466	NP_056281	Q9H3S7	PTN23_HUMAN	protein tyrosine phosphatase, non-receptor type	250	TPR 1.|BRO1.				cilium morphogenesis	cilium|cytoplasmic membrane-bounded vesicle|microtubule basal body	protein tyrosine phosphatase activity			breast(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000271)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		ACTTCGCAGCCGTGGCTCATG	0.627		NA											9	23					0	0	0	0
SCAP	22937	broad.mit.edu	37	3	47484421	47484421	+	Silent	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:47484421G>A	uc003crh.1	-	2	318	c.63C>T	c.(61-63)CTC>CTT	p.L21L	SCAP_uc011baz.1_5'UTR|SCAP_uc003crg.2_5'UTR	NM_012235	NP_036367	Q12770	SCAP_HUMAN	SREBF chaperone protein	21	Helical; Name=1; (Potential).				cholesterol metabolic process|negative regulation of cholesterol biosynthetic process|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane	unfolded protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000278)|KIRC - Kidney renal clear cell carcinoma(197;0.00592)|Kidney(197;0.00679)		AGGATGCACAGAGGAGCCCAT	0.537		NA											6	29					0	0	0	0
NAT6	24142	broad.mit.edu	37	3	50334679	50334679	+	Silent	SNP	C	C	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:50334679C>A	uc003czi.2	-	2	319	c.216G>T	c.(214-216)CTG>CTT	p.L72L	HYAL3_uc003czc.1_Intron|HYAL3_uc003czd.1_Intron|HYAL3_uc003cze.1_Intron|HYAL3_uc003czf.1_Intron|HYAL3_uc003czg.1_Intron|NAT6_uc003czj.2_Silent_p.L94L|NAT6_uc003czk.3_Silent_p.L72L|NAT6_uc003czl.1_Silent_p.L72L	NM_012191	NP_036323	Q93015	NAT6_HUMAN	N-acetyltransferase 6	72	N-acetyltransferase.					cytoplasm	N-acetyltransferase activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		CACAAGCATCCAGGAGCTCGG	0.642		NA											9	40					0.000442599	0.000460739	1	0
CACNA1D	776	broad.mit.edu	37	3	53834389	53834389	+	Silent	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:53834389C>T	uc003dgv.3	+	41	5200	c.5037C>T	c.(5035-5037)TTC>TTT	p.F1679F	CACNA1D_uc003dgu.3_Silent_p.F1699F|CACNA1D_uc003dgy.3_Silent_p.F1664F|CACNA1D_uc003dgw.3_Silent_p.F1346F|CACNA1D_uc003dgx.1_Silent_p.F855F|CACNA1D_uc011bes.1_RNA	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	1679	Cytoplasmic (Potential).				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	ATGATGTGTTCAAAGTAATTA	0.468		NA											17	49					0	0	0	0
SLMAP	7871	broad.mit.edu	37	3	57857389	57857389	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:57857389G>A	uc003dje.1	+	12	1418	c.1213G>A	c.(1213-1215)GAC>AAC	p.D405N	SLMAP_uc003djc.1_Intron|SLMAP_uc003djd.1_Missense_Mutation_p.D388N|SLMAP_uc003djf.1_Intron|SLMAP_uc003djg.1_Intron	NM_007159	NP_009090	Q14BN4	SLMAP_HUMAN	sarcolemma associated protein	405	Cytoplasmic (Potential).				muscle contraction|protein folding	integral to plasma membrane|microtubule organizing center|prefoldin complex|sarcolemma|smooth endoplasmic reticulum	unfolded protein binding				0				BRCA - Breast invasive adenocarcinoma(55;0.000271)|KIRC - Kidney renal clear cell carcinoma(284;0.0602)|Kidney(284;0.0754)|OV - Ovarian serous cystadenocarcinoma(275;0.182)		GAGTGGCGGGGACTGCACTTT	0.358		NA											9	38					0	0	0	0
DZIP3	9666	broad.mit.edu	37	3	108380811	108380811	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:108380811C>T	uc003dxd.2	+	20	2709	c.2287C>T	c.(2287-2289)CAG>TAG	p.Q763*	DZIP3_uc003dxf.1_Nonsense_Mutation_p.Q763*|DZIP3_uc011bhm.1_Nonsense_Mutation_p.Q214*	NM_014648	NP_055463	Q86Y13	DZIP3_HUMAN	DAZ interacting protein 3, zinc finger	763					protein polyubiquitination	cytoplasm	polyubiquitin binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						ATTGCACTATCAGTGTGAAGT	0.373		NA											10	23					0	0	0	0
DPPA2	151871	broad.mit.edu	37	3	109026903	109026903	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:109026903C>G	uc003dxo.2	-	6	881	c.634G>C	c.(634-636)GAG>CAG	p.E212Q		NM_138815	NP_620170	Q7Z7J5	DPPA2_HUMAN	developmental pluripotency associated 2	212						nucleus	nucleic acid binding			ovary(2)|upper_aerodigestive_tract(1)	3						AAAAAGGCCTCAACAGAAACA	0.458		NA											11	15					0	0	0	0
ARHGAP31	57514	broad.mit.edu	37	3	119135106	119135106	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:119135106G>C	uc003ecj.3	+	12	4862	c.4330G>C	c.(4330-4332)GAA>CAA	p.E1444Q		NM_020754	NP_065805	Q2M1Z3	RHG31_HUMAN	Cdc42 GTPase-activating protein	1444					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity			ovary(2)	2						GAGGCAAATAGAATGATTTCG	0.463		NA											14	31					0	0	0	0
GOLGB1	2804	broad.mit.edu	37	3	121410602	121410602	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:121410602C>G	uc003eei.3	-	14	7720	c.7594G>C	c.(7594-7596)GAA>CAA	p.E2532Q	GOLGB1_uc010hrc.2_Missense_Mutation_p.E2537Q|GOLGB1_uc003eej.3_Missense_Mutation_p.E2498Q	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	2532	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		TGGATCAGTTCTGCATCTAGC	0.398		NA											51	116					0	0	0	0
GOLGB1	2804	broad.mit.edu	37	3	121411229	121411229	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:121411229C>G	uc003eei.3	-	14	7093	c.6967G>C	c.(6967-6969)GAT>CAT	p.D2323H	GOLGB1_uc010hrc.2_Missense_Mutation_p.D2328H|GOLGB1_uc003eej.3_Missense_Mutation_p.D2289H	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	2323	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		TTACTTAAATCAGTCAACTGG	0.373		NA											24	66					0	0	0	0
HEG1	57493	broad.mit.edu	37	3	124731790	124731790	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:124731790C>T	uc003ehs.3	-	6	2701	c.2633G>A	c.(2632-2634)GGA>GAA	p.G878E	HEG1_uc011bke.1_Missense_Mutation_p.G978E	NM_020733	NP_065784	Q9ULI3	HEG1_HUMAN	HEG homolog 1 precursor	878	Extracellular (Potential).					extracellular region|integral to membrane	calcium ion binding			ovary(2)	2						GAGCTGTTTTCCAGCTGTAGT	0.507		NA											21	72					0	0	0	0
TPRA1	131601	broad.mit.edu	37	3	127298673	127298673	+	Silent	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:127298673G>A	uc003ejl.2	-	2	459	c.168C>T	c.(166-168)CTC>CTT	p.L56L	TPRA1_uc003ejm.2_RNA|TPRA1_uc003ejo.2_Silent_p.L56L|TPRA1_uc010hsk.2_Silent_p.L56L|TPRA1_uc003ejn.2_Silent_p.L56L	NM_016372	NP_057456	Q86W33	TPRA1_HUMAN	G protein-coupled receptor 175 isoform 1	56	Helical; Name=1; (Potential).				aging|lipid metabolic process	integral to membrane	G-protein coupled receptor activity				0						AGATGAGGAAGAGCACATTGG	0.582		NA											4	43					0	0	0	0
PLXND1	23129	broad.mit.edu	37	3	129324855	129324855	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:129324855C>T	uc003emx.2	-	1	728	c.628G>A	c.(628-630)GGC>AGC	p.G210S		NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	plexin D1 precursor	210	Extracellular (Potential).|Sema.				axon guidance	integral to membrane|intracellular|plasma membrane				large_intestine(1)	1						TACGTGGCGCCCACGAGCAGG	0.607		NA											3	12					0	0	0	0
RASA2	5922	broad.mit.edu	37	3	141272764	141272764	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:141272764C>T	uc003etz.1	+	6	593	c.593C>T	c.(592-594)TCT>TTT	p.S198F	RASA2_uc010huq.1_Missense_Mutation_p.S198F|RASA2_uc003eua.1_Missense_Mutation_p.S198F|RASA2_uc011bnc.1_5'UTR	NM_006506	NP_006497	Q15283	RASA2_HUMAN	RAS p21 protein activator 2	198	C2 2.				intracellular signal transduction|negative regulation of Ras protein signal transduction	intracellular membrane-bounded organelle|intrinsic to internal side of plasma membrane|perinuclear region of cytoplasm	metal ion binding|Ras GTPase activator activity			ovary(2)|lung(2)|breast(1)|skin(1)	6						GCAACAGTTTCTCTAGTGGGC	0.323		NA											21	63					0	0	0	0
SI	6476	broad.mit.edu	37	3	164733862	164733862	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:164733862G>A	uc003fei.2	-	32	3828	c.3766C>T	c.(3766-3768)CAG>TAG	p.Q1256*		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1256	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TCTGTGTACTGAACATCCTGA	0.333		NA								HNSCC(35;0.089)			24	75					0	0	0	0
SLITRK3	22865	broad.mit.edu	37	3	164906954	164906954	+	Silent	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:164906954G>C	uc003fej.3	-	2	2109	c.1665C>G	c.(1663-1665)GTC>GTG	p.V555V	SLITRK3_uc003fek.2_Silent_p.V555V	NM_014926	NP_055741	O94933	SLIK3_HUMAN	slit and trk like 3 protein precursor	555	Extracellular (Potential).					integral to membrane				ovary(6)|skin(3)|pancreas(1)	10						GGTCTATCTGGACAATGGCAT	0.527		NA								HNSCC(40;0.11)			4	50					0	0	0	0
LRRC31	79782	broad.mit.edu	37	3	169572619	169572619	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:169572619C>G	uc003fgc.1	-	6	1050	c.973G>C	c.(973-975)GAT>CAT	p.D325H	LRRC31_uc010hwp.1_Missense_Mutation_p.D269H	NM_024727	NP_079003	Q6UY01	LRC31_HUMAN	leucine rich repeat containing 31	325	LRR 4.									ovary(2)|skin(1)	3	all_cancers(22;2.76e-22)|all_epithelial(15;4.73e-27)|all_lung(20;9.24e-17)|Lung NSC(18;3.85e-16)|Ovarian(172;0.000223)|Breast(254;0.197)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00943)			ATCACGTCATCTGCTGTTAGT	0.408		NA											16	63					0	0	0	0
TTC14	151613	broad.mit.edu	37	3	180327993	180327993	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:180327993G>T	uc003fkk.2	+	12	2108	c.1976G>T	c.(1975-1977)AGA>ATA	p.R659I	TTC14_uc003fkl.2_3'UTR|TTC14_uc003fkm.2_Intron	NM_133462	NP_597719	Q96N46	TTC14_HUMAN	tetratricopeptide repeat domain 14 isoform a	659							RNA binding			ovary(1)	1	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			GAGCACTATAGAAGGTGGGAA	0.403		NA											9	39					0.000274275	0.000286037	1	0
DCUN1D1	54165	broad.mit.edu	37	3	182683478	182683478	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:182683478C>T	uc003fld.1	-	2	116	c.67G>A	c.(67-69)GAA>AAA	p.E23K	DCUN1D1_uc011bqn.1_5'UTR	NM_020640	NP_065691	Q96GG9	DCNL1_HUMAN	RP42 homolog	23	UBA-like.					ubiquitin ligase complex	protein binding			ovary(1)	1	all_cancers(143;9.04e-15)|Ovarian(172;0.0355)		all cancers(12;2.54e-44)|Epithelial(37;4.71e-38)|LUSC - Lung squamous cell carcinoma(7;5.04e-25)|Lung(8;5.03e-23)|OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)			GCTGTTTTTTCACTAGATTGT	0.323		NA											18	53					0	0	0	0
EIF4G1	1981	broad.mit.edu	37	3	184039824	184039824	+	Silent	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:184039824C>T	uc003fnp.2	+	10	1650	c.1452C>T	c.(1450-1452)CTC>CTT	p.L484L	EIF4G1_uc003fno.1_Silent_p.L425L|EIF4G1_uc010hxw.1_Silent_p.L320L|EIF4G1_uc003fnt.2_Silent_p.L195L|EIF4G1_uc003fnq.2_Silent_p.L397L|EIF4G1_uc003fnr.2_Silent_p.L320L|EIF4G1_uc010hxx.2_Silent_p.L491L|EIF4G1_uc003fns.2_Silent_p.L444L|EIF4G1_uc010hxy.2_Silent_p.L491L|EIF4G1_uc003fnv.3_Silent_p.L484L|EIF4G1_uc003fnu.3_Silent_p.L484L|EIF4G1_uc003fnw.2_Silent_p.L491L|EIF4G1_uc003fnx.2_Silent_p.L288L|EIF4G1_uc003fny.3_Silent_p.L288L	NM_198241	NP_937884	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4	484					insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			lung(2)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			AGGAACTGCTCCCCCCAGAGA	0.418		NA											18	49					0	0	0	0
EIF4G1	1981	broad.mit.edu	37	3	184039888	184039888	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:184039888C>G	uc003fnp.2	+	10	1714	c.1516C>G	c.(1516-1518)CAA>GAA	p.Q506E	EIF4G1_uc003fno.1_Missense_Mutation_p.Q447E|EIF4G1_uc010hxw.1_Missense_Mutation_p.Q342E|EIF4G1_uc003fnt.2_Missense_Mutation_p.Q217E|EIF4G1_uc003fnq.2_Missense_Mutation_p.Q419E|EIF4G1_uc003fnr.2_Missense_Mutation_p.Q342E|EIF4G1_uc010hxx.2_Missense_Mutation_p.Q513E|EIF4G1_uc003fns.2_Missense_Mutation_p.Q466E|EIF4G1_uc010hxy.2_Missense_Mutation_p.Q513E|EIF4G1_uc003fnv.3_Missense_Mutation_p.Q506E|EIF4G1_uc003fnu.3_Missense_Mutation_p.Q506E|EIF4G1_uc003fnw.2_Missense_Mutation_p.Q513E|EIF4G1_uc003fnx.2_Missense_Mutation_p.Q310E|EIF4G1_uc003fny.3_Missense_Mutation_p.Q310E	NM_198241	NP_937884	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4	506					insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			lung(2)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			AGCAGCCACTCAAGGTAAGGT	0.532		NA											14	55					0	0	0	0
EIF4G1	1981	broad.mit.edu	37	3	184044351	184044351	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:184044351C>T	uc003fnp.2	+	22	3457	c.3259C>T	c.(3259-3261)CCT>TCT	p.P1087S	EIF4G1_uc003fnt.2_Missense_Mutation_p.P798S|EIF4G1_uc003fnq.2_Missense_Mutation_p.P1000S|EIF4G1_uc003fnr.2_Missense_Mutation_p.P923S|EIF4G1_uc010hxx.2_Missense_Mutation_p.P1094S|EIF4G1_uc003fns.2_Missense_Mutation_p.P1047S|EIF4G1_uc010hxy.2_Missense_Mutation_p.P1094S|EIF4G1_uc003fnv.3_Missense_Mutation_p.P1088S|EIF4G1_uc003fnu.3_Missense_Mutation_p.P1087S|EIF4G1_uc003fnw.2_Missense_Mutation_p.P1094S|EIF4G1_uc003fnx.2_Missense_Mutation_p.P892S|EIF4G1_uc003fny.3_Missense_Mutation_p.P891S|EIF4G1_uc003foa.2_5'Flank	NM_198241	NP_937884	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4	1087					insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			lung(2)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GCTCTTTGCACCTGGAGGGCG	0.597		NA											18	47					0	0	0	0
PCYT1A	5130	broad.mit.edu	37	3	195965715	195965715	+	Silent	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr3:195965715C>T	uc003fwg.2	-	10	1121	c.948G>A	c.(946-948)CCG>CCA	p.P316P	uc003fwf.1_5'Flank|PCYT1A_uc003fwh.2_Silent_p.P316P	NM_005017	NP_005008	P49585	PCY1A_HUMAN	choline phosphate cytidylyltransferase 1 alpha	316						cytosol|soluble fraction	choline-phosphate cytidylyltransferase activity				0	all_cancers(143;1.19e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.28e-24)|all cancers(36;1.01e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00259)	Choline(DB00122)	GGCTCTGCTTCGGGCTGATGG	0.587		NA											3	12					0	0	0	0
PCGF3	10336	broad.mit.edu	37	4	755157	755157	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr4:755157C>G	uc011bva.1	+	10	1028	c.553C>G	c.(553-555)CTG>GTG	p.L185V	PCGF3_uc003gbd.1_RNA|PCGF3_uc003gbe.2_Missense_Mutation_p.L185V|PCGF3_uc010ibh.2_Missense_Mutation_p.L185V|PCGF3_uc003gbg.1_Missense_Mutation_p.L151V|PCGF3_uc003gbh.2_Missense_Mutation_p.L151V	NM_006315	NP_006306	Q3KNV8	PCGF3_HUMAN	ring finger protein 3	185					regulation of transcription, DNA-dependent|transcription, DNA-dependent	PcG protein complex	zinc ion binding				0						CGTCTTGCATCTGAAGAAGTT	0.488		NA											18	51					0	0	0	0
GAK	2580	broad.mit.edu	37	4	844827	844827	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr4:844827G>A	uc003gbm.3	-	26	3753	c.3554C>T	c.(3553-3555)TCC>TTC	p.S1185F	GAK_uc003gbn.3_Missense_Mutation_p.S1106F|GAK_uc003gbk.3_Intron|GAK_uc010ibi.2_Missense_Mutation_p.S410F|GAK_uc010ibj.2_RNA|GAK_uc003gbl.3_Missense_Mutation_p.S1038F	NM_005255	NP_005246	O14976	GAK_HUMAN	cyclin G associated kinase	1185					cell cycle	focal adhesion|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|heat shock protein binding|protein serine/threonine kinase activity			lung(2)|central_nervous_system(1)|skin(1)	4				Colorectal(103;0.219)		GCCTTGATTGGACAACAGATC	0.388		NA											25	75					0	0	0	0
RGS12	6002	broad.mit.edu	37	4	3317944	3317944	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr4:3317944C>T	uc003ggw.2	+	2	951	c.47C>T	c.(46-48)TCG>TTG	p.S16L	RGS12_uc003ggu.2_Missense_Mutation_p.S16L|RGS12_uc010ics.1_Intron|RGS12_uc011bvr.1_RNA|RGS12_uc003ggv.2_Missense_Mutation_p.S16L|RGS12_uc003ggx.1_Missense_Mutation_p.S16L	NM_198229	NP_937872	O14924	RGS12_HUMAN	regulator of G-protein signalling 12 isoform 1	16						condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		CCTGGGCCGTCGCCCCCAAGG	0.607		NA											25	94					0	0	0	0
SLC34A2	10568	broad.mit.edu	37	4	25676182	25676182	+	Silent	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr4:25676182C>T	uc003grr.2	+	12	1470	c.1389C>T	c.(1387-1389)ATC>ATT	p.I463I	SLC34A2_uc003grs.2_Silent_p.I462I|SLC34A2_uc010iev.2_Silent_p.I462I	NM_006424	NP_006415	O95436	NPT2B_HUMAN	solute carrier family 34 (sodium phosphate),	463	Extracellular (Potential).				cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			skin(3)|ovary(1)|kidney(1)	5		Breast(46;0.0503)				GCTCCAACATCGGCACCACCA	0.592		NA											15	58					0	0	0	0
SLC10A4	201780	broad.mit.edu	37	4	48490651	48490651	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr4:48490651G>C	uc003gyc.2	+	3	1228	c.1009G>C	c.(1009-1011)GGT>CGT	p.G337R	ZAR1_uc003gyd.2_5'Flank	NM_152679	NP_689892	Q96EP9	NTCP4_HUMAN	solute carrier family 10, member 4	337	Cytoplasmic (Potential).					integral to membrane	bile acid:sodium symporter activity			central_nervous_system(1)	1						TCTGGAAACAGGTAGTCAGAA	0.443		NA											36	95					0	0	0	0
LPHN3	23284	broad.mit.edu	37	4	62679581	62679581	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr4:62679581C>G	uc010ihh.2	+	6	1423	c.1250C>G	c.(1249-1251)TCT>TGT	p.S417C	LPHN3_uc003hcq.3_Missense_Mutation_p.S417C|LPHN3_uc003hcs.1_Missense_Mutation_p.S246C	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	417	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						caccttgactctgagctagaa	0.144		NA											7	40					0	0	0	0
SULT1E1	6783	broad.mit.edu	37	4	70710039	70710039	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr4:70710039T>C	uc003heo.2	-	7	725	c.612A>G	c.(610-612)ATA>ATG	p.I204M		NM_005420	NP_005411	P49888	ST1E1_HUMAN	estrogen sulfotransferase	204	PAPS.				3'-phosphoadenosine 5'-phosphosulfate metabolic process|sulfation|xenobiotic metabolic process	cytosol|nuclear membrane	estrone sulfotransferase activity|flavonol 3-sulfotransferase activity|steroid binding|steroid sulfotransferase activity			ovary(1)	1						GTATCAATTTTATCACCTCTT	0.343		NA											8	63					0	0	0	0
PPBP	5473	broad.mit.edu	37	4	74853901	74853901	+	Splice_Site	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr4:74853901G>A	uc003hhj.2	-	1	1	c.-79_splice	c.e1-1			NM_002704	NP_002695	P02775	CXCL7_HUMAN	pro-platelet basic protein precursor						chemotaxis|defense response to bacterium|immune response|platelet activation|platelet degranulation|positive regulation of cell division	extracellular space|platelet alpha granule lumen	chemokine activity|glucose transmembrane transporter activity|growth factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(15;0.00136)		all cancers(17;0.00273)|Lung(101;0.196)			CAAGTCTGCAGATAAGTGGCT	0.478		NA											9	19					0	0	0	0
CXCL3	2921	broad.mit.edu	37	4	74904074	74904074	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr4:74904074G>A	uc003hhl.2	-	2	319	c.157C>T	c.(157-159)CAC>TAC	p.H53Y		NM_002090	NP_002081	P19876	CXCL3_HUMAN	chemokine (C-X-C motif) ligand 3	53					immune response|inflammatory response|neutrophil chemotaxis	extracellular space	chemokine activity			central_nervous_system(1)	1	Breast(15;0.00612)		all cancers(17;0.00273)|Lung(101;0.196)			TTCTTGAGGTGAATTCCCTGC	0.607		NA											15	61					0	0	0	0
KIAA1109	84162	broad.mit.edu	37	4	123109097	123109097	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr4:123109097C>G	uc003ieh.2	+	7	720	c.675C>G	c.(673-675)ATC>ATG	p.I225M	KIAA1109_uc003iei.1_Translation_Start_Site	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	225					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						CTCTGTGCATCAACTTTGATG	0.358		NA											13	52					0	0	0	0
SPATA5	166378	broad.mit.edu	37	4	123844435	123844435	+	Silent	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr4:123844435G>A	uc003iez.3	+	1	211	c.138G>A	c.(136-138)CTG>CTA	p.L46L	SPATA5_uc003iey.2_Silent_p.L46L|NUDT6_uc003iew.2_5'Flank|NUDT6_uc003iex.2_5'Flank	NM_145207	NP_660208	Q8NB90	SPAT5_HUMAN	spermatogenesis associated 5	46					cell differentiation|multicellular organismal development|spermatogenesis	mitochondrion	ATP binding|nucleoside-triphosphatase activity				0						CCGGGACTCTGACGGTGACCA	0.587		NA											35	84					0	0	0	0
FAT4	79633	broad.mit.edu	37	4	126238052	126238052	+	Silent	SNP	G	G	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr4:126238052G>T	uc003ifj.3	+	1	486	c.486G>T	c.(484-486)TCG>TCT	p.S162S		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	162	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CCACCGACTCGGACATCGGCT	0.617		NA									OREG0016317	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	24					0.00909568	0.00932409	1	0
SETD7	80854	broad.mit.edu	37	4	140468192	140468192	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr4:140468192C>T	uc003ihw.2	-	2	338	c.52G>A	c.(52-54)GAT>AAT	p.D18N	SETD7_uc003ihx.2_Missense_Mutation_p.D18N	NM_030648	NP_085151	Q8WTS6	SETD7_HUMAN	SET domain-containing protein 7	18					peptidyl-lysine dimethylation|peptidyl-lysine monomethylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	histone-lysine N-methyltransferase activity|p53 binding			ovary(1)|central_nervous_system(1)	2	all_hematologic(180;0.156)					AATCCGTCATCGTCCAGGTGC	0.522		NA											13	40					0	0	0	0
MAML3	55534	broad.mit.edu	37	4	140811093	140811093	+	Silent	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr4:140811093C>T	uc003ihz.1	-	2	2249	c.1497G>A	c.(1495-1497)CAG>CAA	p.Q499Q	MAML3_uc011chd.1_Intron	NM_018717	NP_061187	Q96JK9	MAML3_HUMAN	mastermind-like 3	499	Gln-rich.				Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity			ovary(1)	1	all_hematologic(180;0.162)					gctgctgctgctgctgctgct	0.264		NA											4	29					0	0	0	0
MAP9	79884	broad.mit.edu	37	4	156281397	156281397	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr4:156281397C>A	uc003ios.2	-	7	1237	c.973G>T	c.(973-975)GAT>TAT	p.D325Y	MAP9_uc011cin.1_Missense_Mutation_p.D300Y|MAP9_uc010iqa.1_RNA|MAP9_uc003iot.1_Missense_Mutation_p.D324Y	NM_001039580	NP_001034669	Q49MG5	MAP9_HUMAN	aster-associated protein	325	Potential.				cell division|mitosis	cytoplasm|microtubule|spindle		p.D325Y(1)		ovary(1)|central_nervous_system(1)	2	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.143)		GTTCTGTCATCATCCATAATC	0.378		NA											13	42					9.31e-06	9.87e-06	1	0
MTNR1A	4543	broad.mit.edu	37	4	187455394	187455394	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr4:187455394G>C	uc003izd.1	-	2	520	c.502C>G	c.(502-504)CTC>GTC	p.L168V		NM_005958	NP_005949	P48039	MTR1A_HUMAN	melatonin receptor 1A	168	Extracellular (Potential).				circadian rhythm|G-protein signaling, coupled to cyclic nucleotide second messenger|mating behavior	integral to plasma membrane	melatonin receptor activity			ovary(1)|skin(1)|breast(1)|central_nervous_system(1)|pancreas(1)	5		all_cancers(14;6.39e-56)|all_epithelial(14;1.48e-41)|all_lung(41;2.45e-15)|Lung NSC(41;7.26e-15)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00335)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|Renal(120;0.0183)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;7.63e-12)|BRCA - Breast invasive adenocarcinoma(30;6.68e-07)|GBM - Glioblastoma multiforme(59;3.44e-05)|LUSC - Lung squamous cell carcinoma(40;0.000106)|STAD - Stomach adenocarcinoma(60;0.000279)|READ - Rectum adenocarcinoma(43;0.159)	Melatonin(DB01065)|Ramelteon(DB00980)	TCGTACTGGAGAGTCCCTGCA	0.602		NA											13	60					0	0	0	0
FAT1	2195	broad.mit.edu	37	4	187628329	187628329	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr4:187628329G>A	uc003izf.2	-	2	2841	c.2653C>T	c.(2653-2655)CGA>TGA	p.R885*	FAT1_uc010iso.1_Nonsense_Mutation_p.R885*	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	885	Extracellular (Potential).|Cadherin 7.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						TGCAGCTCTCGATCCAGAGGG	0.512		NA								HNSCC(5;0.00058)			13	64					0	0	0	0
TARS	6897	broad.mit.edu	37	5	33455163	33455163	+	Silent	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr5:33455163C>T	uc003jhy.2	+	5	862	c.567C>T	c.(565-567)CTC>CTT	p.L189L	TARS_uc011cob.1_Silent_p.L177L|TARS_uc010iup.1_Silent_p.L130L|TARS_uc011coc.1_Silent_p.L210L|TARS_uc003jhz.2_Silent_p.L85L|TARS_uc011cod.1_Silent_p.L68L	NM_152295	NP_689508	P26639	SYTC_HUMAN	threonyl-tRNA synthetase	189					threonyl-tRNA aminoacylation	cytosol	ATP binding|protein homodimerization activity|threonine-tRNA ligase activity			ovary(2)	2					L-Threonine(DB00156)	ACATGTACCTCGAAGAAGGGT	0.388		NA											13	27					0	0	0	0
NIPBL	25836	broad.mit.edu	37	5	36976261	36976261	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr5:36976261C>G	uc003jkl.3	+	9	1751	c.1252C>G	c.(1252-1254)CAA>GAA	p.Q418E	NIPBL_uc003jkk.3_Missense_Mutation_p.Q418E|NIPBL_uc003jkm.1_Missense_Mutation_p.Q297E	NM_133433	NP_597677	Q6KC79	NIPBL_HUMAN	delangin isoform A	418	Gln-rich.				brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			AAATGCTGCTCAATGTTTGTC	0.413		NA											21	58					0	0	0	0
SFRS12	140890	broad.mit.edu	37	5	65459693	65459693	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr5:65459693G>C	uc003juo.2	+	7	1141	c.481G>C	c.(481-483)GAA>CAA	p.E161Q	SFRS12_uc003jun.2_Missense_Mutation_p.E277Q|SFRS12_uc010iwy.2_Missense_Mutation_p.E161Q	NM_139168	NP_631907	Q8WXA9	SREK1_HUMAN	splicing factor, arginine/serine-rich 12 isoform	161					mRNA processing|RNA splicing	spliceosomal complex	nucleic acid binding|nucleotide binding|protein binding				0		Lung NSC(167;9.34e-06)|Prostate(74;0.00187)|Ovarian(174;0.0545)|Breast(144;0.0928)|Colorectal(97;0.234)		Lung(70;0.00449)		GGAGTTAGAAGAAGTAATGAA	0.363		NA											18	61					0	0	0	0
BDP1	55814	broad.mit.edu	37	5	70841044	70841044	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr5:70841044G>A	uc003kbp.1	+	32	7005	c.6742G>A	c.(6742-6744)GAG>AAG	p.E2248K	BDP1_uc003kbo.2_Missense_Mutation_p.E2248K|BDP1_uc003kbq.1_RNA|BDP1_uc003kbr.1_RNA	NM_018429	NP_060899	A6H8Y1	BDP1_HUMAN	transcription factor-like nuclear regulator	2248					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			skin(2)	2		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		TCCTGTGCCAGAGGTAAAAGA	0.328		NA											12	48					0	0	0	0
PPIP5K2	23262	broad.mit.edu	37	5	102472491	102472491	+	Silent	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr5:102472491C>T	uc003kod.3	+	4	885	c.366C>T	c.(364-366)ATC>ATT	p.I122I	PPIP5K2_uc011cva.1_RNA|PPIP5K2_uc003koe.2_Silent_p.I122I|PPIP5K2_uc010jbo.1_Silent_p.I44I	NM_015216	NP_056031	O43314	VIP2_HUMAN	Histidine acid phosphatase domain containing 1	122					inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity			ovary(1)|skin(1)	2						CATTTGTAATCAATGACTTGA	0.303		NA											42	135					0	0	0	0
FBXL17	64839	broad.mit.edu	37	5	107700445	107700445	+	Silent	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr5:107700445G>C	uc011cvc.1	-	3	1775	c.1368C>G	c.(1366-1368)CTC>CTG	p.L456L	FBXL17_uc003kon.3_Silent_p.L58L	NM_001163315	NP_001156787	Q9UF56	FXL17_HUMAN	F-box and leucine-rich repeat protein 17	456											0		all_cancers(142;0.00273)|all_epithelial(76;0.000362)|Prostate(80;0.0115)|Myeloproliferative disorder(839;0.0393)|Ovarian(225;0.232)		OV - Ovarian serous cystadenocarcinoma(64;9.63e-11)|Epithelial(69;4.02e-10)		TTACCTGCTTGAGTCCTTCAT	0.343		NA											19	60					0	0	0	0
MCC	4163	broad.mit.edu	37	5	112418582	112418582	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr5:112418582C>T	uc003kqj.3	-	9	1719	c.1189G>A	c.(1189-1191)GAG>AAG	p.E397K	MCC_uc003kqk.3_RNA|MCC_uc003kql.3_Missense_Mutation_p.E587K|MCC_uc011cwb.1_Missense_Mutation_p.E397K|MCC_uc010jcd.1_Missense_Mutation_p.E359K	NM_002387	NP_002378	P23508	CRCM_HUMAN	mutated in colorectal cancers isoform 2	397					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane	protein binding|receptor activity			ovary(1)	1		all_cancers(142;5.89e-08)|all_epithelial(76;3.57e-11)|all_lung(232;0.000605)|Lung NSC(810;0.000697)|Colorectal(10;0.00146)|Prostate(80;0.00174)|Ovarian(225;0.0175)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(64;2.04e-54)|Epithelial(69;9.69e-49)|all cancers(49;6.25e-44)|COAD - Colon adenocarcinoma(37;0.0432)|Colorectal(14;0.0766)		GTTTCCACCTCAAACTCTCTA	0.478		NA											23	81					0	0	0	0
FBN2	2201	broad.mit.edu	37	5	127637197	127637197	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr5:127637197C>G	uc003kuu.2	-	47	6362	c.5923G>C	c.(5923-5925)GAT>CAT	p.D1975H		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	1975	EGF-like 33; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		CTGCACTCATCTATGTCTGTA	0.353		NA											26	73					0	0	0	0
HSPA4	3308	broad.mit.edu	37	5	132439956	132439956	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr5:132439956C>G	uc003kyj.2	+	19	2632	c.2351C>G	c.(2350-2352)TCA>TGA	p.S784*		NM_002154	NP_002145	P34932	HSP74_HUMAN	heat shock 70kDa protein 4	784					cellular chaperone-mediated protein complex assembly|protein import into mitochondrial outer membrane|response to unfolded protein	cytoplasm|nucleus	ATP binding			lung(1)|breast(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CCTATAATTTCAAAGCCCAAA	0.433		NA											11	41					0	0	0	0
SMAD5	4090	broad.mit.edu	37	5	135496568	135496568	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr5:135496568C>T	uc003lbj.1	+	5	871	c.427C>T	c.(427-429)CGT>TGT	p.R143C	SMAD5_uc003lbk.1_Missense_Mutation_p.R143C|SMAD5_uc003lbl.1_Missense_Mutation_p.R143C	NM_001001419	NP_001001419	Q99717	SMAD5_HUMAN	SMAD family member 5	143					BMP signaling pathway|embryonic pattern specification|positive regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytosol|integral to membrane|transcription factor complex	sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|ubiquitin protein ligase binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			ATTAGTGCCTCGTCATAATGA	0.418		NA											22	91					0	0	0	0
SLC23A1	9963	broad.mit.edu	37	5	138707763	138707763	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr5:138707763C>T	uc003leh.2	-	14	1826	c.1729G>A	c.(1729-1731)GAT>AAT	p.D577N	SLC23A1_uc003leg.2_Missense_Mutation_p.D581N	NM_005847	NP_005838	Q9UHI7	S23A1_HUMAN	solute carrier family 23 (nucleobase	577					brain development|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|response to toxin|transepithelial L-ascorbic acid transport|water-soluble vitamin metabolic process	apical plasma membrane|cytoplasm|integral to plasma membrane|intracellular organelle|membrane fraction	dehydroascorbic acid transporter activity|L-ascorbate:sodium symporter activity|nucleobase transmembrane transporter activity|protein binding|sodium-dependent L-ascorbate transmembrane transporter activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)		Vitamin C(DB00126)	GCAATCTGATCTTTTGAACTT	0.398		NA											37	138					0	0	0	0
UBE2D2	7322	broad.mit.edu	37	5	138979957	138979957	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr5:138979957G>C	uc003ler.2	+	2	651	c.25G>C	c.(25-27)GAA>CAA	p.E9Q	UBE2D2_uc003leq.2_5'UTR	NM_003339	NP_003330	P62837	UB2D2_HUMAN	ubiquitin-conjugating enzyme E2D 2 isoform 1	9					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process		ATP binding|protein binding|ubiquitin-protein ligase activity			central_nervous_system(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			TTTTCTGTAGGAATTGAATGA	0.348		NA											9	24					0	0	0	0
PCDHB15	56121	broad.mit.edu	37	5	140625334	140625334	+	Missense_Mutation	SNP	G	G	A	rs2907300		TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr5:140625334G>A	uc003lje.2	+	1	188	c.188G>A	c.(187-189)GGA>GAA	p.G63E		NM_018935	NP_061758	Q9Y5E8	PCDBF_HUMAN	protocadherin beta 15 precursor	63	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|breast(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCCGAGCGGGGAGCCCGGGTA	0.552		NA											11	40					0	0	0	0
PCDHGA5	56110	broad.mit.edu	37	5	140743929	140743929	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr5:140743929G>A	uc003lju.1	+	1	32	c.32G>A	c.(31-33)GGA>GAA	p.G11E	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc011das.1_Missense_Mutation_p.G11E	NM_018918	NP_061741	Q9Y5G8	PCDG5_HUMAN	protocadherin gamma subfamily A, 5 isoform 1	11					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGGGCTGCGGAGAGCTGCTG	0.582		NA											6	20					0	0	0	0
SPINK9	643394	broad.mit.edu	37	5	147715230	147715230	+	Silent	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr5:147715230C>T	uc003lpe.1	+	1	109	c.54C>T	c.(52-54)TTC>TTT	p.F18F	uc003lpb.1_Intron	NM_001040433	NP_001035523	Q5DT21	ISK9_HUMAN	serine peptidase inhibitor, Kazal type 9	18						extracellular region	protein binding|serine-type endopeptidase inhibitor activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAACCATGTTCAGTGAGTATC	0.433		NA											10	80					0	0	0	0
ZNF300	91975	broad.mit.edu	37	5	150275396	150275396	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr5:150275396C>G	uc003lsy.1	-	6	1672	c.1405G>C	c.(1405-1407)GAA>CAA	p.E469Q	IRGM_uc011dcl.1_Intron	NM_052860	NP_443092	Q96RE9	ZN300_HUMAN	zinc finger protein 300	469	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2		Medulloblastoma(196;0.109)|all_hematologic(541;0.131)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TTTCCACATTCAGTACATTCA	0.413		NA											12	45					0	0	0	0
GRIA1	2890	broad.mit.edu	37	5	153026577	153026577	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr5:153026577C>T	uc003lva.3	+	3	675	c.310C>T	c.(310-312)CTC>TTC	p.L104F	GRIA1_uc003luy.3_Missense_Mutation_p.L104F|GRIA1_uc003luz.3_Missense_Mutation_p.L9F|GRIA1_uc011dcv.1_RNA|GRIA1_uc011dcw.1_Intron|GRIA1_uc011dcx.1_Missense_Mutation_p.L35F|GRIA1_uc011dcy.1_Missense_Mutation_p.L114F|GRIA1_uc011dcz.1_Missense_Mutation_p.L114F|GRIA1_uc010jia.1_Missense_Mutation_p.L84F	NM_001114183	NP_001107655	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1 isoform	104	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			ovary(4)|skin(2)	6		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	TTGTGGGGCCCTCCACGTCTG	0.498		NA											29	82					0	0	0	0
FAM114A2	10827	broad.mit.edu	37	5	153390822	153390822	+	Silent	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr5:153390822G>A	uc003lvb.2	-	9	1560	c.972C>T	c.(970-972)TCC>TCT	p.S324S	FAM114A2_uc003lvc.2_Silent_p.S324S|FAM114A2_uc003lvd.2_Silent_p.S324S|FAM114A2_uc003lve.2_Silent_p.S140S|FAM114A2_uc011dda.1_Silent_p.S254S	NM_018691	NP_061161	Q9NRY5	F1142_HUMAN	hypothetical protein LOC10827	324							purine nucleotide binding				0						TCTCTGGTTTGGAGGAAACGT	0.368		NA											11	53					0	0	0	0
KIF4B	285643	broad.mit.edu	37	5	154397020	154397020	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr5:154397020G>C	uc010jih.1	+	1	3761	c.3601G>C	c.(3601-3603)GAA>CAA	p.E1201Q		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	1201	Interaction with PRC1 (By similarity).|Globular (By similarity).				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			TGGAGCAACAGAATACCAACA	0.507		NA											7	25					0	0	0	0
GABRA1	2554	broad.mit.edu	37	5	161322869	161322869	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr5:161322869G>A	uc010jiw.2	+	10	1522	c.1054G>A	c.(1054-1056)GAA>AAA	p.E352K	GABRA1_uc010jix.2_Missense_Mutation_p.E352K|GABRA1_uc010jiy.2_Missense_Mutation_p.E352K|GABRA1_uc003lyx.3_Missense_Mutation_p.E352K|GABRA1_uc010jiz.2_Missense_Mutation_p.E352K|GABRA1_uc010jja.2_Missense_Mutation_p.E352K|GABRA1_uc010jjb.2_Missense_Mutation_p.E352K	NM_000806	NP_000797	P14867	GBRA1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha	352	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|pancreas(1)	3	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.228)	Alprazolam(DB00404)|Butabarbital(DB00237)|Butalbital(DB00241)|Butethal(DB01353)|Chlordiazepoxide(DB00475)|Clobazam(DB00349)|Clonazepam(DB01068)|Clorazepate(DB00628)|Desflurane(DB01189)|Diazepam(DB00829)|Enflurane(DB00228)|Ethanol(DB00898)|Ethchlorvynol(DB00189)|Etomidate(DB00292)|Flumazenil(DB01205)|Flurazepam(DB00690)|Halazepam(DB00801)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Lorazepam(DB00186)|Meprobamate(DB00371)|Metharbital(DB00463)|Methohexital(DB00474)|Methoxyflurane(DB01028)|Methylphenobarbital(DB00849)|Methyprylon(DB01107)|Midazolam(DB00683)|Nitrazepam(DB01595)|Oxazepam(DB00842)|Pentobarbital(DB00312)|Phenobarbital(DB01174)|Picrotoxin(DB00466)|Prazepam(DB01588)|Primidone(DB00794)|Progabide(DB00837)|Propofol(DB00818)|Quazepam(DB01589)|Secobarbital(DB00418)|Sevoflurane(DB01236)|Talbutal(DB00306)|Thiamylal(DB01154)|Thiopental(DB00599)|Topiramate(DB00273)|Zaleplon(DB00962)|Zolpidem(DB00425)	TGTGGTTCCAGAAAAGGTAAA	0.393		NA											26	62					0	0	0	0
GABRA1	2554	broad.mit.edu	37	5	161324342	161324342	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr5:161324342C>A	uc010jiw.2	+	11	1753	c.1285C>A	c.(1285-1287)CTG>ATG	p.L429M	GABRA1_uc010jix.2_Missense_Mutation_p.L429M|GABRA1_uc010jiy.2_Missense_Mutation_p.L429M|GABRA1_uc003lyx.3_Missense_Mutation_p.L429M|GABRA1_uc010jiz.2_Missense_Mutation_p.L429M|GABRA1_uc010jja.2_Missense_Mutation_p.L429M|GABRA1_uc010jjb.2_Missense_Mutation_p.L429M	NM_000806	NP_000797	P14867	GBRA1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha	429	Helical; (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|pancreas(1)	3	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.228)	Alprazolam(DB00404)|Butabarbital(DB00237)|Butalbital(DB00241)|Butethal(DB01353)|Chlordiazepoxide(DB00475)|Clobazam(DB00349)|Clonazepam(DB01068)|Clorazepate(DB00628)|Desflurane(DB01189)|Diazepam(DB00829)|Enflurane(DB00228)|Ethanol(DB00898)|Ethchlorvynol(DB00189)|Etomidate(DB00292)|Flumazenil(DB01205)|Flurazepam(DB00690)|Halazepam(DB00801)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Lorazepam(DB00186)|Meprobamate(DB00371)|Metharbital(DB00463)|Methohexital(DB00474)|Methoxyflurane(DB01028)|Methylphenobarbital(DB00849)|Methyprylon(DB01107)|Midazolam(DB00683)|Nitrazepam(DB01595)|Oxazepam(DB00842)|Pentobarbital(DB00312)|Phenobarbital(DB01174)|Picrotoxin(DB00466)|Prazepam(DB01588)|Primidone(DB00794)|Progabide(DB00837)|Propofol(DB00818)|Quazepam(DB01589)|Secobarbital(DB00418)|Sevoflurane(DB01236)|Talbutal(DB00306)|Thiamylal(DB01154)|Thiopental(DB00599)|Topiramate(DB00273)|Zaleplon(DB00962)|Zolpidem(DB00425)	AGCCTTCCCGCTGCTATTTGG	0.428		NA											24	101					7.88e-14	8.55e-14	1	0
DRD1	1812	broad.mit.edu	37	5	174869513	174869513	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr5:174869513G>A	uc003mcz.2	-	2	1535	c.590C>T	c.(589-591)TCA>TTA	p.S197L		NM_000794	NP_000785	P21728	DRD1_HUMAN	dopamine receptor D1	197	Helical; Name=5; (Potential).				activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|adult walking behavior|cerebral cortex GABAergic interneuron migration|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|mating behavior|positive regulation of cAMP biosynthetic process|positive regulation of cell migration|positive regulation of potassium ion transport|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of synaptic transmission, glutamatergic|prepulse inhibition|response to drug|synapse assembly|visual learning	endoplasmic reticulum membrane|membrane fraction	protein binding			ovary(2)|skin(1)	3	all_cancers(89;0.00895)|Renal(175;0.000159)|Lung NSC(126;0.00625)|all_lung(126;0.0104)	Medulloblastoma(196;0.0208)|all_neural(177;0.0277)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)		Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Carphenazine(DB01038)|Chlorprothixene(DB01239)|Clozapine(DB00363)|Cocaine(DB00907)|Dopamine(DB00988)|Fenoldopam(DB00800)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Methylergonovine(DB00353)|Minaprine(DB00805)|Olanzapine(DB00334)|Pegademase bovine(DB00061)|Pergolide(DB01186)|Perphenazine(DB00850)|Prochlorperazine(DB00433)|Promazine(DB00420)|Propiomazine(DB00777)|Quetiapine(DB01224)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Triflupromazine(DB00508)|Zuclopenthixol(DB01624)	TACAGAGGATGAGATGGCATA	0.502		NA											13	84					0	0	0	0
GPRIN1	114787	broad.mit.edu	37	5	176026823	176026823	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr5:176026823C>T	uc003meo.1	-	2	188	c.13G>A	c.(13-15)GAA>AAA	p.E5K		NM_052899	NP_443131	Q7Z2K8	GRIN1_HUMAN	G protein-regulated inducer of neurite outgrowth	5						growth cone|plasma membrane				ovary(2)	2	all_cancers(89;0.00263)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCCGGGTCTTCAGCAGTGTCC	0.612		NA											3	16					0	0	0	0
NSD1	64324	broad.mit.edu	37	5	176709547	176709547	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr5:176709547G>C	uc003mfr.3	+	19	6112	c.5974G>C	c.(5974-5976)GAT>CAT	p.D1992H	NSD1_uc003mft.3_Missense_Mutation_p.D1723H|NSD1_uc011dfx.1_Missense_Mutation_p.D1640H	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1992	SET.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		TCAAGAACATGATATCACTAA	0.378		NA	T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			29	81					0	0	0	0
NSD1	64324	broad.mit.edu	37	5	176709577	176709577	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr5:176709577G>C	uc003mfr.3	+	19	6142	c.6004G>C	c.(6004-6006)GAC>CAC	p.D2002H	NSD1_uc003mft.3_Missense_Mutation_p.D1733H|NSD1_uc011dfx.1_Missense_Mutation_p.D1650H	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	2002	SET.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		GCTCACCCTAGACAAAGTAAG	0.388		NA	T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			23	66					0	0	0	0
SERPINB6	5269	broad.mit.edu	37	6	2954925	2954925	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:2954925G>C	uc003muk.2	-	3	2326	c.331C>G	c.(331-333)CAA>GAA	p.Q111E	SERPINB6_uc003mui.2_5'UTR|SERPINB6_uc003muj.2_RNA|SERPINB6_uc003mul.2_Missense_Mutation_p.Q111E|SERPINB6_uc003mum.2_Missense_Mutation_p.Q111E|SERPINB6_uc003mun.2_Missense_Mutation_p.Q111E|SERPINB6_uc003muo.2_Missense_Mutation_p.Q111E	NM_004568	NP_004559	P35237	SPB6_HUMAN	serine (or cysteine) proteinase inhibitor, clade	111					regulation of proteolysis	centrosome|cytosol|protein complex	protease binding|serine-type endopeptidase inhibitor activity				0	Ovarian(93;0.0412)	all_hematologic(90;0.0895)			Drotrecogin alfa(DB00055)	TAGAATTTTTGGCAGGAATCT	0.443		NA											12	42					0	0	0	0
BMP6	654	broad.mit.edu	37	6	7861772	7861772	+	Missense_Mutation	SNP	C	C	G	rs147293908	byFrequency	TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:7861772C>G	uc003mxu.3	+	3	1124	c.946C>G	c.(946-948)CTG>GTG	p.L316V		NM_001718	NP_001709	P22004	BMP6_HUMAN	bone morphogenetic protein 6 preproprotein	316					BMP signaling pathway|cartilage development|growth|immune response|positive regulation of aldosterone biosynthetic process|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	BMP receptor binding|cytokine activity|growth factor activity|protein heterodimerization activity			large_intestine(2)|ovary(1)	3	Ovarian(93;0.0721)					CACTAGCAATCTGTGGGTTGT	0.502		NA											30	88					0	0	0	0
TFAP2A	7020	broad.mit.edu	37	6	10404933	10404933	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:10404933G>C	uc003myr.2	-	4	824	c.572C>G	c.(571-573)TCC>TGC	p.S191C	TFAP2A_uc003myq.2_Missense_Mutation_p.S185C|TFAP2A_uc003mys.2_RNA|TFAP2A_uc011dih.1_Missense_Mutation_p.S191C|TFAP2A_uc003myt.2_Missense_Mutation_p.S187C|TFAP2A_uc003myu.1_Missense_Mutation_p.S191C	NM_003220	NP_003211	P05549	AP2A_HUMAN	transcription factor AP-2 alpha isoform a	191					ectoderm development|positive regulation of bone mineralization|positive regulation of tooth mineralization|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	centrosome|Golgi apparatus|nucleus	chromatin binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding			ovary(1)	1	Breast(50;0.0427)|Ovarian(93;0.0991)	all_hematologic(90;0.107)				AGGGATGGCGGAGACGGCATT	0.627		NA											11	52					0	0	0	0
NRSN1	140767	broad.mit.edu	37	6	24145891	24145891	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:24145891A>G	uc010jpq.1	+	4	542	c.305A>G	c.(304-306)GAC>GGC	p.D102G		NM_080723	NP_542454	Q8IZ57	NRSN1_HUMAN	neurensin 1	102					nervous system development	growth cone|integral to membrane|neuronal cell body|transport vesicle					0						GTGGTGGTCGACACACATGCT	0.527		NA											34	31					0	0	0	0
SLC17A3	10786	broad.mit.edu	37	6	25862525	25862525	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:25862525G>C	uc003nfi.3	-	3	349	c.239C>G	c.(238-240)TCT>TGT	p.S80C	SLC17A3_uc003nfk.3_Missense_Mutation_p.S80C|SLC17A3_uc011djz.1_Missense_Mutation_p.S80C|SLC17A3_uc011dka.1_Missense_Mutation_p.S80C	NM_006632	NP_006623	O00476	NPT4_HUMAN	solute carrier family 17 (sodium phosphate),	80					glucose-6-phosphate transport|urate metabolic process	apical plasma membrane|brush border membrane|endoplasmic reticulum membrane|integral to plasma membrane|perinuclear region of cytoplasm	drug transmembrane transporter activity|efflux transmembrane transporter activity|organic anion transmembrane transporter activity|sodium:phosphate symporter activity|toxin transporter activity|urate transmembrane transporter activity|voltage-gated anion channel activity				0						CAGCACCTCAGAGGAATCATT	0.428		NA											5	64					0	0	0	0
HIST1H1A	3024	broad.mit.edu	37	6	26017460	26017460	+	Silent	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:26017460C>T	uc003nfo.2	-	1	581	c.501G>A	c.(499-501)AAG>AAA	p.K167K		NM_005325	NP_005316	Q02539	H11_HUMAN	histone cluster 1, H1a	167					nucleosome assembly|spermatogenesis	nucleosome|nucleus	DNA binding			ovary(2)	2						TTTTTGGATTCTTGGAGGATT	0.473		NA											41	156					0	0	0	0
HIST1H3E	8353	broad.mit.edu	37	6	26225488	26225488	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:26225488G>A	uc003nhb.2	+	2	466	c.106G>A	c.(106-108)GTG>ATG	p.V36M	HIST1H3E_uc003nhc.3_Missense_Mutation_p.V36M	NM_021018	NP_066298	P68431	H31_HUMAN	histone cluster 1, H3f	36					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding				0		all_hematologic(11;0.0223)|Acute lymphoblastic leukemia(11;0.0351)				CACGGGCGGCGTGAAGAAGCC	0.622		NA											31	24					0	0	0	0
HIST1H2BK	85236	broad.mit.edu	37	6	27114494	27114494	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:27114494C>G	uc003nix.1	-	1	126	c.84G>C	c.(82-84)AAG>AAC	p.K28N	HIST1H2AH_uc003niz.2_5'Flank|hsa-mir-3143|MI0014167_5'Flank	NM_080593	NP_542160	O60814	H2B1K_HUMAN	histone cluster 1, H2bk	28					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding				0						GCTTGCGCTTCTTGCCGTCCT	0.597		NA											20	142					0	0	0	0
HLA-A	3105	broad.mit.edu	37	6	29912344	29912344	+	Silent	SNP	G	G	A	rs45513603		TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:29912344G>A	uc003nol.2	+	5	963	c.963G>A	c.(961-963)GTG>GTA	p.V321V	HLA-G_uc011dmb.1_Intron|HCG4P6_uc003nog.1_5'Flank|HLA-A_uc010jrq.2_Silent_p.V200V|HLA-A_uc003nok.2_Silent_p.V200V|HLA-A_uc003non.2_Silent_p.V321V|HLA-A_uc003noo.2_Silent_p.V321V|HLA-A_uc010jrr.2_Intron|HLA-A_uc003nom.2_Silent_p.V200V|HLA-A_uc010klp.2_Intron|HLA-A_uc011dmc.1_Silent_p.V200V|HLA-A_uc011dmd.1_Silent_p.V200V	NM_002116	NP_002107	P30443	1A01_HUMAN	major histocompatibility complex, class I, A	321	Helical; (Potential).				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2						TTGGAGCTGTGATCACTGGAG	0.592		NA							Melanoma_Familial_Clustering_of|Lichen_Sclerosis_et_Atrophicus_Familial_Clustering_of|Osteosarcoma_Familial_Clustering_of|Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of	Multiple Myeloma(9;0.094)			29	47					0	0	0	0
NFKBIL1	4795	broad.mit.edu	37	6	31525604	31525604	+	Silent	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:31525604G>A	uc003nub.2	+	3	653	c.534G>A	c.(532-534)CAG>CAA	p.Q178Q	NFKBIL1_uc011dnr.1_Intron|NFKBIL1_uc011dns.1_Silent_p.Q155Q|NFKBIL1_uc011dnt.1_RNA|NFKBIL1_uc003nuc.2_Intron	NM_005007	NP_004998	Q9UBC1	IKBL1_HUMAN	nuclear factor of kappa light polypeptide gene	178					cytoplasmic sequestering of transcription factor		protein binding				0						ACGAGTGGCAGGAAGTCATGG	0.567		NA											4	30					0	0	0	0
LTB	4050	broad.mit.edu	37	6	31548552	31548552	+	Silent	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:31548552G>A	uc003nuk.2	-	4	677	c.669C>T	c.(667-669)ATC>ATT	p.I223I	LTB_uc003nul.2_3'UTR	NM_002341	NP_002332	Q06643	TNFC_HUMAN	lymphotoxin-beta isoform a	223	Extracellular (Potential).				cell-cell signaling|immune response|positive regulation of interleukin-12 biosynthetic process|signal transduction	extracellular space|integral to membrane	cytokine activity|tumor necrosis factor receptor binding				0					Infliximab(DB00065)|Simvastatin(DB00641)	CGGGGTGACTGATGTTGACGT	0.622		NA											6	22					0	0	0	0
BAT3	7917	broad.mit.edu	37	6	31606973	31606973	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:31606973C>T	uc003nvg.3	-	25	3648	c.3334G>A	c.(3334-3336)GAA>AAA	p.E1112K	BAT3_uc003nvf.3_Missense_Mutation_p.E1106K|BAT3_uc003nvh.3_Missense_Mutation_p.E1106K|BAT3_uc003nvi.3_Missense_Mutation_p.E1106K|BAT3_uc011dnw.1_Missense_Mutation_p.E1057K|BAT3_uc011dnx.1_Missense_Mutation_p.E883K	NM_004639	NP_004630	P46379	BAG6_HUMAN	HLA-B associated transcript-3 isoform a	1112					apoptosis in response to endoplasmic reticulum stress|brain development|cell differentiation|chromatin modification|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|embryo development|internal peptidyl-lysine acetylation|kidney development|lung development|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|protein stabilization|spermatogenesis|synaptonemal complex assembly|tail-anchored membrane protein insertion into ER membrane|transport|ubiquitin-dependent protein catabolic process	BAT3 complex|nucleus	polyubiquitin binding|proteasome binding|ribosome binding				0						TTGGGGTCTTCCTGCAGTCGT	0.537		NA											3	19					0	0	0	0
CYP21A2	1589	broad.mit.edu	37	6	31974817	31974817	+	Silent	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:31974817C>T	uc010jtp.2	+	7	797	c.679C>T	c.(679-681)CTG>TTG	p.L227L	CYP21A2_uc011dpb.1_Silent_p.L197L			P08686	CP21A_HUMAN	SubName: Full=Cytochrome P450, family 21, subfamily A, polypeptide 2; SubName: Full=Cytochrome P450 21-hydroxylase; SubName: Full=Cytochrome P450, family 21, subfamily A, polypeptide 2, isoform CRA_b; SubName: Full=DJ34F7.3 (Cytochrome P450, subfamily XXIA (Steroid 21-hydroxylase, congenital adrenal hyperplasia), polypeptide 2 (CYP21, P450c21B)); SubName: Full=cDNA, FLJ95495, Homo sapiens cytochrome P450, family 21, subfamily A, polypeptide 2(CYP21A2), mRNA;	226					glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|steroid 21-monooxygenase activity|steroid binding				0						TCTCCGGAGGCTGAAGCAGGC	0.627		NA											4	11					0	0	0	0
TAP2	6891	broad.mit.edu	37	6	32782246	32782246	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:32782246C>T	uc011dqf.1	-	14	2437	c.2315G>A	c.(2314-2316)AGA>AAA	p.R772K	HLA-DOB_uc003oca.2_Missense_Mutation_p.R165K|HLA-DOB_uc011dqg.1_Missense_Mutation_p.R165K	NM_018833	NP_061313	Q03519	TAP2_HUMAN	transporter 2, ATP-binding cassette, sub-family	Error:Variant_position_missing_in_Q03519_after_alignment					antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent|antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent|antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent|cytosol to ER transport|intracellular transport of viral proteins in host cell|peptide antigen transport|positive regulation of antigen processing and presentation of peptide antigen via MHC class I|positive regulation of T cell mediated cytotoxicity	nucleus|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|peptide antigen-transporting ATPase activity|TAP1 binding|TAP2 binding|tapasin binding				0						GACCCCAGCTCTCTCCTCCTG	0.522		NA											29	98					0	0	0	0
ZBTB22	9278	broad.mit.edu	37	6	33284041	33284041	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:33284041G>A	uc003oeb.2	-	2	805	c.653C>T	c.(652-654)TCA>TTA	p.S218L	TAPBP_uc003odx.1_5'Flank|TAPBP_uc010jus.1_5'Flank|TAPBP_uc003ody.2_5'Flank|TAPBP_uc003odz.2_5'Flank|TAPBP_uc010jut.1_5'Flank|TAPBP_uc011drc.1_5'Flank|ZBTB22_uc010juu.2_Missense_Mutation_p.S218L	NM_005453	NP_005444	O15209	ZBT22_HUMAN	zinc finger and BTB domain containing 22	218					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GGAGGAAGATGAGAAATCAGT	0.612		NA											6	39					0	0	0	0
TREM1	54210	broad.mit.edu	37	6	41250194	41250194	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:41250194G>C	uc003oqf.1	-	2	409	c.345C>G	c.(343-345)ATC>ATG	p.I115M	TREM1_uc003oqg.1_Missense_Mutation_p.I115M	NM_018643	NP_061113	Q9NP99	TREM1_HUMAN	triggering receptor expressed on myeloid cells 1	115	Extracellular (Potential).|Ig-like V-type.				blood coagulation|humoral immune response|intracellular signal transduction|leukocyte migration	extracellular region|integral to membrane|intracellular|plasma membrane	receptor activity			breast(1)	1	Ovarian(28;0.0327)|Colorectal(47;0.196)				Glutathione(DB00143)	GAGGCTGGTAGATCACACACT	0.537		NA											6	27					0	0	0	0
PRPH2	5961	broad.mit.edu	37	6	42666224	42666224	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:42666224G>A	uc003osk.2	-	3	1136	c.850C>T	c.(850-852)CGC>TGC	p.R284C		NM_000322	NP_000313	P23942	PRPH2_HUMAN	peripherin 2	284	Helical; (Potential).				cell adhesion|visual perception	integral to membrane				ovary(4)|central_nervous_system(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.00178)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.0904)			TGTAGGTAGCGCAGCCCAATT	0.587		NA											11	21					0	0	0	0
TDRD6	221400	broad.mit.edu	37	6	46660213	46660213	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:46660213G>T	uc003oyj.2	+	1	4348	c.4348G>T	c.(4348-4350)GAA>TAA	p.E1450*	TDRD6_uc010jze.2_Nonsense_Mutation_p.E1444*	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	1450					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			AATAAGATGTGAATTTGTTAA	0.383		NA											33	109					2.51e-30	2.75e-30	1	0
CRISP3	10321	broad.mit.edu	37	6	49704110	49704110	+	Silent	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:49704110C>T	uc003ozs.2	-	3	198	c.183G>A	c.(181-183)CTG>CTA	p.L61L		NM_006061	NP_006052	P54108	CRIS3_HUMAN	cysteine-rich secretory protein 3 precursor	61					innate immune response	proteinaceous extracellular matrix|specific granule				skin(2)	2	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			TTACCATCTTCAGCATGTTTC	0.438		NA											43	96					0	0	0	0
PGK2	5232	broad.mit.edu	37	6	49754450	49754450	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:49754450G>A	uc003ozu.2	-	1	558	c.451C>T	c.(451-453)CGA>TGA	p.R151*		NM_138733	NP_620061	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	151					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			ovary(1)	1	Lung NSC(77;0.0402)					AGTGATGCTCGGAAGGCTTCT	0.502		NA											20	52					0	0	0	0
IL17A	3605	broad.mit.edu	37	6	52053869	52053869	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:52053869G>C	uc003pak.1	+	3	292	c.247G>C	c.(247-249)GAG>CAG	p.E83Q		NM_002190	NP_002181	Q16552	IL17_HUMAN	interleukin 17A precursor	83					apoptosis|cell-cell signaling|fibroblast activation|immune response|inflammatory response|positive regulation of interleukin-23 production|positive regulation of osteoclast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein glycosylation	extracellular space	cytokine activity				0	Lung NSC(77;0.116)					TGAGGACCCTGAGAGATATCC	0.502		NA											8	28					0	0	0	0
GSTA1	2938	broad.mit.edu	37	6	52659022	52659022	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:52659022C>T	uc003paz.2	-	5	427	c.315G>A	c.(313-315)ATG>ATA	p.M105I		NM_145740	NP_665683	P08263	GSTA1_HUMAN	glutathione S-transferase alpha 1	105	GST C-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			ovary(1)	1	Lung NSC(77;0.118)				Amsacrine(DB00276)|Busulfan(DB01008)|Glutathione(DB00143)	GAAGGAGGATCATTTCACCCA	0.378		NA											43	108					0	0	0	0
FAM83B	222584	broad.mit.edu	37	6	54806332	54806332	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:54806332C>G	uc003pck.2	+	5	2679	c.2563C>G	c.(2563-2565)CAA>GAA	p.Q855E		NM_001010872	NP_001010872	Q5T0W9	FA83B_HUMAN	hypothetical protein LOC222584	855										ovary(6)	6	Lung NSC(77;0.0178)|Renal(3;0.122)					TAGCCCATCTCAAGAGATAAA	0.438		NA											7	34					0	0	0	0
REV3L	5980	broad.mit.edu	37	6	111688626	111688626	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:111688626G>A	uc003puy.3	-	14	6688	c.6365C>T	c.(6364-6366)TCT>TTT	p.S2122F	REV3L_uc003pux.3_Missense_Mutation_p.S2044F|REV3L_uc003puz.3_Missense_Mutation_p.S2044F|REV3L_uc003pva.1_RNA	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta	2122					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		AATTACTGGAGAATCAGGGGA	0.438		NA						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					19	173					0	0	0	0
AIG1	51390	broad.mit.edu	37	6	143486275	143486275	+	Silent	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:143486275G>A	uc003qjh.2	+	3	394	c.354G>A	c.(352-354)CCG>CCA	p.P118P	AIG1_uc003qjf.2_Silent_p.P108P|AIG1_uc003qji.2_Silent_p.P56P|AIG1_uc011edw.1_Silent_p.P118P|AIG1_uc003qjg.2_Silent_p.P118P	NM_016108	NP_057192	Q9NVV5	AIG1_HUMAN	androgen-induced 1	118						integral to membrane					0				OV - Ovarian serous cystadenocarcinoma(155;2.34e-05)|GBM - Glioblastoma multiforme(68;0.0246)		TGATATACCCGAAGCTGCTGG	0.358		NA											22	100					0	0	0	0
C6orf97	80129	broad.mit.edu	37	6	151939129	151939129	+	Silent	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:151939129G>A	uc003qol.2	+	11	2084	c.1995G>A	c.(1993-1995)GTG>GTA	p.V665V		NM_025059	NP_079335	Q8IYT3	CF097_HUMAN	hypothetical protein LOC80129	665											0		Ovarian(120;0.126)	BRCA - Breast invasive adenocarcinoma(37;0.111)	OV - Ovarian serous cystadenocarcinoma(155;1.48e-10)		GCTTGAACGTGACCAGCCTTG	0.443		NA											5	71					0	0	0	0
WTAP	9589	broad.mit.edu	37	6	160164726	160164726	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:160164726G>T	uc003qsl.2	+	5	397	c.175G>T	c.(175-177)GAA>TAA	p.E59*	WTAP_uc010kjx.2_Nonsense_Mutation_p.E59*|WTAP_uc003qsk.2_Nonsense_Mutation_p.E59*|WTAP_uc003qsm.1_RNA|WTAP_uc003qsn.2_Nonsense_Mutation_p.E59*	NM_004906	NP_004897	Q15007	FL2D_HUMAN	Wilms' tumour 1-associating protein isoform 1	59					cell cycle|mRNA processing|RNA splicing	nuclear membrane|nucleolus					0		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.75e-18)|BRCA - Breast invasive adenocarcinoma(81;5.93e-06)		AAGAGAGTCTGAAGAAAAACT	0.363		NA											9	33					2.18e-05	2.3e-05	1	0
THBS2	7058	broad.mit.edu	37	6	169623478	169623478	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:169623478C>G	uc003qwt.2	-	19	3114	c.2866G>C	c.(2866-2868)GAG>CAG	p.E956Q		NM_003247	NP_003238	P35442	TSP2_HUMAN	thrombospondin 2 precursor	956	TSP type-3 8.				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			ovary(5)	5		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		AAGTCTGTCTCACTGATGGCA	0.468		NA											13	67					0	0	0	0
TBP	6908	broad.mit.edu	37	6	170873691	170873691	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr6:170873691C>T	uc003qxt.2	+	4	788	c.556C>T	c.(556-558)CGT>TGT	p.R186C	TBP_uc003qxu.2_Missense_Mutation_p.R186C|TBP_uc011ehf.1_Missense_Mutation_p.R166C	NM_003194	NP_003185	P20226	TBP_HUMAN	TATA box binding protein	186	1				cell death|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|viral reproduction	transcription factor TFIIA complex|transcription factor TFIID complex	repressing transcription factor binding|transcription regulatory region DNA binding			ovary(1)	1		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;1.07e-22)|BRCA - Breast invasive adenocarcinoma(81;5.01e-06)|GBM - Glioblastoma multiforme(31;0.00591)		CATTGCACTTCGTGCCCGAAA	0.318		NA											11	34					0	0	0	0
EIF2AK1	27102	broad.mit.edu	37	7	6089666	6089666	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr7:6089666C>G	uc003spp.2	-	3	434	c.288G>C	c.(286-288)CAG>CAC	p.Q96H	EIF2AK1_uc003spq.2_Missense_Mutation_p.Q96H|EIF2AK1_uc011jwm.1_Intron	NM_014413	NP_055228	Q9BQI3	E2AK1_HUMAN	eukaryotic translation initiation factor 2-alpha	96					negative regulation of hemoglobin biosynthetic process|negative regulation of translational initiation by iron|protein autophosphorylation|response to external stimulus|response to stress	cytoplasm	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|heme binding|protein homodimerization activity			upper_aerodigestive_tract(1)|stomach(1)|lung(1)|central_nervous_system(1)	4		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.106)|OV - Ovarian serous cystadenocarcinoma(56;5.22e-14)		TGATAAACGTCTGGCAAAGTA	0.318		NA											9	35					0	0	0	0
RAC1	5879	broad.mit.edu	37	7	6426892	6426892	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr7:6426892C>A	uc003spx.2	+	2	326	c.85C>A	c.(85-87)CCT>ACT	p.P29T	RAC1_uc003spw.2_Missense_Mutation_p.P29T	NM_006908	NP_008839	P63000	RAC1_HUMAN	ras-related C3 botulinum toxin substrate 1	29					actin filament polymerization|apoptosis|axon guidance|cell motility|cell-matrix adhesion|induction of apoptosis by extracellular signals|inflammatory response|lamellipodium assembly|localization within membrane|negative regulation of interleukin-23 production|negative regulation of receptor-mediated endocytosis|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of lamellipodium assembly|positive regulation of Rho protein signal transduction|regulation of cell migration|regulation of defense response to virus by virus|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst|ruffle organization|small GTPase mediated signal transduction|T cell costimulation|viral reproduction	cytosol|melanosome|plasma membrane	GTP binding|GTP-dependent protein binding|GTPase activity|thioesterase binding			lung(2)	2		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.104)	Pravastatin(DB00175)|Simvastatin(DB00641)	CAATGCATTTCCTGGAGAATA	0.353		NA											20	54					9.96e-16	1.08e-15	1	0
TMEM106B	54664	broad.mit.edu	37	7	12254482	12254482	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr7:12254482G>A	uc011jxk.1	+	3	446	c.46G>A	c.(46-48)GAT>AAT	p.D16N	TMEM106B_uc003ssh.2_Missense_Mutation_p.D16N	NM_018374	NP_060844	Q9NUM4	T106B_HUMAN	transmembrane protein 106B	16						integral to membrane					0				UCEC - Uterine corpus endometrioid carcinoma (126;0.185)		AAGCAAAGAAGATGCTTATGA	0.353		NA											11	31					0	0	0	0
DNAH11	8701	broad.mit.edu	37	7	21678666	21678666	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr7:21678666G>T	uc003svc.2	+	28	4973	c.4942G>T	c.(4942-4944)GGA>TGA	p.G1648*		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1648	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						TCTCTCAAAAGGAGCTCAGCC	0.398		NA							Kartagener_syndrome				9	47					3.1e-07	3.31e-07	1	0
STK31	56164	broad.mit.edu	37	7	23768842	23768842	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr7:23768842G>C	uc003sws.3	+	6	524	c.457G>C	c.(457-459)GAT>CAT	p.D153H	STK31_uc003swt.3_Missense_Mutation_p.D130H|STK31_uc011jze.1_Missense_Mutation_p.D153H|STK31_uc010kuq.2_Missense_Mutation_p.D130H	NM_031414	NP_113602	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31 isoform a	153							ATP binding|nucleic acid binding|protein serine/threonine kinase activity			skin(3)|lung(2)|ovary(2)|stomach(2)	9						CATTCCTTCTGATCAAGAAGT	0.328		NA											10	22					0	0	0	0
CHN2	1124	broad.mit.edu	37	7	29552289	29552289	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr7:29552289G>A	uc003szz.2	+	13	1782	c.1345G>A	c.(1345-1347)GAT>AAT	p.D449N	CHN2_uc011jzs.1_Missense_Mutation_p.D524N|CHN2_uc010kva.2_3'UTR|CHN2_uc010kvb.2_RNA|CHN2_uc010kvc.2_Missense_Mutation_p.D414N|CHN2_uc011jzt.1_Missense_Mutation_p.D462N|CHN2_uc010kvd.2_Missense_Mutation_p.D305N|CHN2_uc011jzu.1_Missense_Mutation_p.D434N|CHN2_uc010kvg.2_Missense_Mutation_p.D267N|CHN2_uc010kvh.2_Missense_Mutation_p.D209N|CHN2_uc010kvi.2_Missense_Mutation_p.D241N|CHN2_uc010kve.2_3'UTR|CHN2_uc003taa.2_Missense_Mutation_p.D313N|CHN2_uc010kvf.2_Missense_Mutation_p.D255N|CHN2_uc010kvj.2_Missense_Mutation_p.D222N|CHN2_uc010kvk.2_Missense_Mutation_p.D124N|CHN2_uc010kvl.2_RNA|CHN2_uc010kvm.2_Missense_Mutation_p.D268N|CHN2_uc011jzv.1_Missense_Mutation_p.D242N	NM_004067	NP_004058	P52757	CHIO_HUMAN	beta chimerin isoform 2	449	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|membrane	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(2)	2						CACCCTGCATGATATGCGGTA	0.463		NA											13	49					0	0	0	0
CCDC129	223075	broad.mit.edu	37	7	31614170	31614170	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr7:31614170G>T	uc003tcj.1	+	7	1405	c.412G>T	c.(412-414)GAA>TAA	p.E138*	CCDC129_uc011kad.1_Nonsense_Mutation_p.E148*|CCDC129_uc003tci.1_Nonsense_Mutation_p.E137*|CCDC129_uc011kae.1_Nonsense_Mutation_p.E164*|CCDC129_uc003tck.1_Nonsense_Mutation_p.E46*	NM_194300	NP_919276	Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	138											0						TGAATGGCTGGAATTTTGGGA	0.438		NA											29	102					4.03e-09	4.35e-09	1	0
UPP1	7378	broad.mit.edu	37	7	48147942	48147942	+	Silent	SNP	G	G	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr7:48147942G>T	uc003toj.2	+	10	1450	c.921G>T	c.(919-921)CTG>CTT	p.L307L	UPP1_uc003tok.2_Silent_p.L307L|UPP1_uc003tol.2_Silent_p.L307L|UPP1_uc011kch.1_Silent_p.L100L|UPP1_uc003ton.2_Silent_p.L170L|UPP1_uc003too.2_Silent_p.L170L	NM_181597	NP_853628	Q16831	UPP1_HUMAN	uridine phosphorylase 1	307					nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside salvage	cytosol	uridine phosphorylase activity				0						AGAAGAAACTGAGCAAGGCCT	0.567		NA											11	30					0.000673444	0.000697866	1	0
EGFR	1956	broad.mit.edu	37	7	55241688	55241688	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr7:55241688C>G	uc003tqk.2	+	18	2382	c.2136C>G	c.(2134-2136)TTC>TTG	p.F712L	EGFR_uc010kzg.1_Missense_Mutation_p.F667L|EGFR_uc011kco.1_Missense_Mutation_p.F659L	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	712	Cytoplasmic (Potential).|Protein kinase.				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.F712L(2)|p.F712S(1)|p.F712F(1)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	AAACTGAATTCAAAAAGATCA	0.562		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			16	49					0	0	0	0
PHTF2	57157	broad.mit.edu	37	7	77558594	77558594	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr7:77558594C>G	uc003ugs.3	+	11	1414	c.1288C>G	c.(1288-1290)CAG>GAG	p.Q430E	PHTF2_uc003ugp.2_Missense_Mutation_p.Q392E|PHTF2_uc003ugq.3_Missense_Mutation_p.Q392E|PHTF2_uc010ldv.2_Missense_Mutation_p.Q392E|PHTF2_uc003ugt.3_Missense_Mutation_p.Q396E|PHTF2_uc003ugu.3_Missense_Mutation_p.Q392E|PHTF2_uc003ugv.2_Missense_Mutation_p.Q255E|PHTF2_uc010ldw.1_Missense_Mutation_p.Q255E	NM_001127357	NP_001120829	Q8N3S3	PHTF2_HUMAN	putative homeodomain transcription factor 2	430					regulation of transcription, DNA-dependent|transcription, DNA-dependent	endoplasmic reticulum|nucleus	DNA binding			ovary(1)	1						GGAAAATCATCAGATTAATCC	0.388		NA											5	14					0	0	0	0
CACNA2D1	781	broad.mit.edu	37	7	81598239	81598239	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr7:81598239C>T	uc003uhr.1	-	29	2615	c.2359G>A	c.(2359-2361)GAA>AAA	p.E787K	CACNA2D1_uc011kgy.1_Intron	NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	799	Extracellular (Potential).					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	ATATATATTTCTACAGCTTTG	0.269		NA											16	76					0	0	0	0
PCLO	27445	broad.mit.edu	37	7	82586178	82586178	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr7:82586178C>T	uc003uhx.2	-	5	4380	c.4091G>A	c.(4090-4092)GGA>GAA	p.G1364E	PCLO_uc003uhv.2_Missense_Mutation_p.G1364E	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1295					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GGAAGAATATCCCGTGTCGCT	0.423		NA											6	24					0	0	0	0
ABCB1	5243	broad.mit.edu	37	7	87179592	87179592	+	Silent	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr7:87179592C>G	uc003uiz.1	-	13	1663	c.1245G>C	c.(1243-1245)CTG>CTC	p.L415L	ABCB1_uc011khc.1_Silent_p.L351L	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	415	ABC transporter 1.|Cytoplasmic (Potential).				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	TCTGCACCTTCAGGTTCAGAC	0.502		NA											8	35					0	0	0	0
ARPC1B	10095	broad.mit.edu	37	7	98992106	98992106	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr7:98992106C>G	uc003upz.2	+	10	1202	c.1113C>G	c.(1111-1113)ATC>ATG	p.I371M	ARPC1B_uc003uqa.2_Missense_Mutation_p.I371M|ARPC1B_uc003uqb.2_Missense_Mutation_p.I371M|ARPC1B_uc003uqc.2_3'UTR|ARPC1B_uc003uqd.2_Missense_Mutation_p.I183M	NM_005720	NP_005711	O15143	ARC1B_HUMAN	actin related protein 2/3 complex subunit 1B	371					cellular component movement|regulation of actin filament polymerization	Arp2/3 protein complex|cytoplasm	actin binding|structural constituent of cytoskeleton				0	all_cancers(62;3.49e-09)|all_epithelial(64;2.57e-10)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)			ACCTCAAGATCAAATGACCTG	0.572		NA											15	52					0	0	0	0
TRIM4	89122	broad.mit.edu	37	7	99489924	99489924	+	Silent	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr7:99489924C>T	uc003usd.2	-	7	1495	c.1365G>A	c.(1363-1365)GGG>GGA	p.G455G	TRIM4_uc003use.2_Silent_p.G429G|TRIM4_uc011kjc.1_Silent_p.G285G	NM_033017	NP_148977	Q9C037	TRIM4_HUMAN	tripartite motif protein TRIM4 isoform alpha	455	B30.2/SPRY.				protein trimerization	cytoplasm|plasma membrane	zinc ion binding			ovary(1)|kidney(1)	2	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)	Ovarian(593;0.238)				AGGAGACATTCCCAGTCCCAC	0.557		NA											23	102					0	0	0	0
C7orf59	389541	broad.mit.edu	37	7	99751027	99751027	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr7:99751027C>T	uc003utq.2	+	3	155	c.89C>T	c.(88-90)TCT>TTT	p.S30F		NM_001008395	NP_001008396	Q0VGL1	CG059_HUMAN	hypothetical protein LOC389541	30											0						ATGCAGTCATCTGGGGACCTG	0.458		NA											32	114					0	0	0	0
SRPK2	6733	broad.mit.edu	37	7	104783666	104783666	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr7:104783666C>G	uc003vct.2	-	9	1079	c.892G>C	c.(892-894)GAA>CAA	p.E298Q	SRPK2_uc003vcu.2_Missense_Mutation_p.E298Q|SRPK2_uc003vcv.2_Missense_Mutation_p.E309Q|SRPK2_uc003vcw.1_Missense_Mutation_p.E298Q	NM_182691	NP_872633	P78362	SRPK2_HUMAN	serine/arginine-rich protein-specific kinase 2	298	Protein kinase.				angiogenesis|cell differentiation|intracellular protein kinase cascade|negative regulation of viral genome replication|nuclear speck organization|positive regulation of cell cycle|positive regulation of cell proliferation|positive regulation of gene expression|positive regulation of neuron apoptosis|positive regulation of viral genome replication|spliceosome assembly	cytoplasm|nucleolus	14-3-3 protein binding|ATP binding|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(3)|ovary(2)|upper_aerodigestive_tract(1)	6						ATTTTCCTTTCAGCTTCTCGC	0.408		NA											18	81					0	0	0	0
C7orf53	286006	broad.mit.edu	37	7	112124970	112124970	+	Silent	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr7:112124970C>T	uc011kmq.1	+	2	234	c.99C>T	c.(97-99)CTC>CTT	p.L33L	C7orf53_uc003vgl.2_RNA|C7orf53_uc003vgm.2_Silent_p.L33L	NM_001134468	NP_001127940	Q8N8F7	CG053_HUMAN	hypothetical protein LOC286006	33						integral to membrane				ovary(1)	1						AACTAAACCTCTGTCCAGCCG	0.478		NA											25	74					0	0	0	0
NDUFA5	4698	broad.mit.edu	37	7	123185709	123185709	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr7:123185709C>T	uc003vks.2	-	4	314	c.205G>A	c.(205-207)GAA>AAA	p.E69K	NDUFA5_uc003vkr.2_RNA	NM_005000	NP_004991	Q16718	NDUA5_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	69					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity				0					NADH(DB00157)	AGTTGGTCTTCTAATTTTTTA	0.313		NA											13	51					0	0	0	0
TMEM209	84928	broad.mit.edu	37	7	129841908	129841908	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr7:129841908C>T	uc003vpn.2	-	5	478	c.355G>A	c.(355-357)GAT>AAT	p.D119N	TMEM209_uc010lmc.1_Missense_Mutation_p.D119N|TMEM209_uc003vpo.2_Missense_Mutation_p.D119N	NM_032842	NP_116231	Q96SK2	TM209_HUMAN	transmembrane protein 209	119						integral to membrane				ovary(2)|large_intestine(1)	3	Melanoma(18;0.0435)					GCTGCCAGATCATGTGGAGGC	0.428		NA											7	29					0	0	0	0
WEE2	494551	broad.mit.edu	37	7	141408625	141408625	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr7:141408625G>A	uc003vwn.2	+	1	473	c.67G>A	c.(67-69)GAG>AAG	p.E23K	FLJ40852_uc011krh.1_Intron|FLJ40852_uc010lnm.2_Intron|FLJ40852_uc010lnn.2_Intron|FLJ40852_uc003vwm.3_Intron|FLJ40852_uc010lno.2_Intron	NM_001105558	NP_001099028	P0C1S8	WEE2_HUMAN	WEE1 homolog 2	23					egg activation|female meiosis|female pronucleus assembly|meiotic metaphase II|meiotic prophase I|mitosis|negative regulation of oocyte development|regulation of meiosis I	centrosome|nucleus	ATP binding|magnesium ion binding|non-membrane spanning protein tyrosine kinase activity|protein serine/threonine kinase activity			ovary(1)|stomach(1)	2	Melanoma(164;0.0171)					TGAGGAGACTGAGATTGAAGG	0.443		NA											24	73					0	0	0	0
TRPV5	56302	broad.mit.edu	37	7	142605909	142605909	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr7:142605909G>C	uc003wby.1	-	15	2225	c.1961C>G	c.(1960-1962)TCA>TGA	p.S654*		NM_019841	NP_062815	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel,	654	Cytoplasmic (Potential).				protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			ovary(3)|central_nervous_system(2)|skin(1)	6	Melanoma(164;0.059)					CTCCTTGTCTGAGTTCTTGAA	0.522		NA											9	34					0	0	0	0
SSPO	23145	broad.mit.edu	37	7	149482281	149482281	+	Silent	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr7:149482281C>G	uc010lpk.2	+	21	2955	c.2955C>G	c.(2953-2955)CCC>CCG	p.P985P	SSPO_uc010lpl.1_Missense_Mutation_p.P321R	NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	985					cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GGTACCTGCCCAACGCCACCA	0.612		NA											11	50					0	0	0	0
GBX1	2636	broad.mit.edu	37	7	150845999	150845999	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr7:150845999G>A	uc011kvg.1	-	2	1001	c.769C>T	c.(769-771)CCT>TCT	p.P257S		NM_001098834	NP_001092304	Q14549	GBX1_HUMAN	gastrulation brain homeo box 1	257						nuclear chromosome	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			OV - Ovarian serous cystadenocarcinoma(82;0.00989)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TTCCCCCCAGGAGCTGTGACC	0.582		NA											26	69					0	0	0	0
XKR6	286046	broad.mit.edu	37	8	10755509	10755509	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr8:10755509C>G	uc003wtk.1	-	3	1906	c.1879G>C	c.(1879-1881)GAC>CAC	p.D627H		NM_173683	NP_775954	Q5GH73	XKR6_HUMAN	XK, Kell blood group complex subunit-related	627						integral to membrane				ovary(1)|skin(1)	2				Lung(29;0.0407)|COAD - Colon adenocarcinoma(149;0.0555)		AGTGGTCCGTCTCGATATCGA	0.463		NA											20	34					0	0	0	0
FGL1	2267	broad.mit.edu	37	8	17731930	17731930	+	Silent	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr8:17731930G>A	uc003wxx.2	-	5	669	c.345C>T	c.(343-345)TCC>TCT	p.S115S	FGL1_uc003wxy.2_Silent_p.S115S|FGL1_uc003wxz.2_Silent_p.S115S|FGL1_uc003wya.2_Silent_p.S115S|FGL1_uc003wyb.2_Silent_p.S115S|FGL1_uc003wyc.2_Silent_p.S115S|FGL1_uc003wyd.2_RNA|FGL1_uc003wye.2_Silent_p.S165S|FGL1_uc003wyf.2_Silent_p.S85S	NM_201553	NP_963847	Q08830	FGL1_HUMAN	fibrinogen-like 1 precursor	115	Fibrinogen C-terminal.				signal transduction	fibrinogen complex	receptor binding				0				Colorectal(111;0.0573)|COAD - Colon adenocarcinoma(73;0.215)		CTCCTCCATCGGACATGTCAC	0.383		NA											29	44					0	0	0	0
NKX3-1	4824	broad.mit.edu	37	8	23538827	23538827	+	Silent	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr8:23538827G>C	uc011kzx.1	-	2	660	c.612C>G	c.(610-612)GCC>GCG	p.A204A	NKX3-1_uc003xdv.1_Intron	NM_006167	NP_006158	Q99801	NKX31_HUMAN	NK3 homeobox 1	204					negative regulation of estrogen receptor binding|negative regulation of transcription, DNA-dependent|positive regulation of cell division|positive regulation of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter	nucleus	estrogen receptor activity|estrogen receptor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region sequence-specific DNA binding				0		Prostate(55;0.114)		Colorectal(74;0.0146)|COAD - Colon adenocarcinoma(73;0.061)|BRCA - Breast invasive adenocarcinoma(99;0.0708)		CCCGGGAGAAGGCCTCCTCTT	0.562		NA											4	44					0	0	0	0
GPR124	25960	broad.mit.edu	37	8	37687368	37687368	+	Splice_Site	SNP	G	G	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr8:37687368G>T	uc003xkj.2	+	6	918	c.555_splice	c.e6-1	p.V185_splice	GPR124_uc010lvy.2_Splice_Site_p.V185_splice	NM_032777	NP_116166	Q96PE1	GP124_HUMAN	G protein-coupled receptor 124 precursor						central nervous system development|endothelial cell migration|neuropeptide signaling pathway|regulation of angiogenesis|regulation of chemotaxis|sprouting angiogenesis	integral to membrane|plasma membrane	G-protein coupled receptor activity			large_intestine(2)|ovary(2)|skin(1)	5			BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)			CCACCCTGCAGGGACTTGGGC	0.667		NA											11	39					5.51e-06	5.85e-06	1	0
SNAI2	6591	broad.mit.edu	37	8	49832516	49832516	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr8:49832516C>G	uc003xqp.2	-	2	728	c.564G>C	c.(562-564)AAG>AAC	p.K188N		NM_003068	NP_003059	O43623	SNAI2_HUMAN	snail 2	188	C2H2-type 3.				canonical Wnt receptor signaling pathway|ectoderm and mesoderm interaction|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		all_cancers(86;0.0368)|all_epithelial(80;0.000624)|Lung NSC(129;0.0019)|all_lung(136;0.00502)				TGCCGCAGATCTTGCAAACAC	0.458		NA											9	72					0	0	0	0
SGK3	23678	broad.mit.edu	37	8	67759505	67759505	+	Silent	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr8:67759505G>C	uc003xwr.2	+	15	1451	c.1152G>C	c.(1150-1152)GTG>GTC	p.V384V	SGK3_uc003xwp.2_Silent_p.V378V|SGK3_uc003xwt.2_Silent_p.V384V|SGK3_uc003xwu.2_Silent_p.V352V	NM_001033578	NP_001028750	Q96BR1	SGK3_HUMAN	serum/glucocorticoid regulated kinase 3 isoform	384	Protein kinase.				cell communication|response to stress	cytoplasmic membrane-bounded vesicle|early endosome	ATP binding|phosphatidylinositol binding|protein serine/threonine kinase activity			ovary(1)|large_intestine(1)|lung(1)|breast(1)	4	Breast(64;0.186)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0046)|OV - Ovarian serous cystadenocarcinoma(28;0.0112)|all cancers(69;0.0141)|BRCA - Breast invasive adenocarcinoma(89;0.206)			GGCCAGGAGTGAGTCTTACAG	0.408		NA											46	56					0	0	0	0
LRRC67	286187	broad.mit.edu	37	8	67926687	67926687	+	Silent	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr8:67926687G>C	uc003xxc.2	-	3	415	c.270C>G	c.(268-270)CTC>CTG	p.L90L		NM_001013626	NP_001013648	Q7Z4L9	LRC67_HUMAN	leucine rich repeat containing 67	90	LRR 3.										0						TTAATGACCTGAGGTTCTCTA	0.289		NA											12	68					0	0	0	0
CSPP1	79848	broad.mit.edu	37	8	68005835	68005835	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr8:68005835G>C	uc003xxi.2	+	7	605	c.574G>C	c.(574-576)GAA>CAA	p.E192Q	CSPP1_uc003xxg.1_Missense_Mutation_p.E184Q|CSPP1_uc003xxh.1_RNA|CSPP1_uc003xxj.2_Missense_Mutation_p.E157Q|CSPP1_uc003xxk.2_5'UTR	NM_001077204	NP_001070672	Q1MSJ5	CSPP1_HUMAN	centrosome spindle pole associated protein 1	192						centrosome|microtubule|spindle				ovary(3)|breast(2)	5	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00145)|OV - Ovarian serous cystadenocarcinoma(28;0.00589)|all cancers(69;0.0069)|BRCA - Breast invasive adenocarcinoma(89;0.153)			GGGTAAGGAAGAATCCAGTGA	0.338		NA											31	40					0	0	0	0
C8orf34	116328	broad.mit.edu	37	8	69633646	69633646	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr8:69633646G>C	uc010lyz.2	+	10	1169	c.1120G>C	c.(1120-1122)GAG>CAG	p.E374Q	C8orf34_uc003xyb.2_Missense_Mutation_p.E349Q	NM_052958	NP_443190	Q49A92	CH034_HUMAN	hypothetical protein LOC116328	374					signal transduction		cAMP-dependent protein kinase regulator activity			large_intestine(1)	1			Epithelial(68;0.0117)|OV - Ovarian serous cystadenocarcinoma(28;0.0227)|all cancers(69;0.0502)			TGACGAATTTGAGAAAGCATC	0.269		NA											12	20					0	0	0	0
ZFHX4	79776	broad.mit.edu	37	8	77766385	77766385	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr8:77766385G>A	uc003yav.2	+	10	7480	c.7093G>A	c.(7093-7095)GCA>ACA	p.A2365T	ZFHX4_uc003yau.1_Missense_Mutation_p.A2410T|ZFHX4_uc003yaw.1_Missense_Mutation_p.A2365T	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2365	Pro-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.A2394T(1)		ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TGAATATCCCGCAGAAAAGCC	0.552		NA								HNSCC(33;0.089)			3	12					0	0	0	0
PAG1	55824	broad.mit.edu	37	8	81899695	81899695	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr8:81899695C>G	uc003ybz.2	-	6	895	c.184G>C	c.(184-186)GAC>CAC	p.D62H		NM_018440	NP_060910	Q9NWQ8	PAG1_HUMAN	phosphoprotein associated with glycosphingolipid	62	Cytoplasmic (Potential).				epidermal growth factor receptor signaling pathway|intracellular signal transduction|T cell receptor signaling pathway	integral to membrane|intracellular|membrane raft|plasma membrane	SH2 domain binding|SH3/SH2 adaptor activity				0	Lung NSC(7;5.76e-06)|all_lung(9;2e-05)		BRCA - Breast invasive adenocarcinoma(6;0.0567)|Epithelial(68;0.0634)|all cancers(69;0.197)			ATCTCCTTGTCTGAAGGCTGa	0.428		NA											7	66					0	0	0	0
RBM12B	389677	broad.mit.edu	37	8	94746486	94746486	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr8:94746486G>A	uc003yfz.2	-	3	2346	c.2153C>T	c.(2152-2154)TCA>TTA	p.S718L		NM_203390	NP_976324	Q8IXT5	RB12B_HUMAN	RNA binding motif protein 12B	718							nucleotide binding|RNA binding				0	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			CTCCTGGGGTGACTGCCTGAA	0.627		NA											7	162					0	0	0	0
PTDSS1	9791	broad.mit.edu	37	8	97299316	97299316	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr8:97299316C>T	uc003yht.1	+	4	485	c.383C>T	c.(382-384)TCT>TTT	p.S128F	PTDSS1_uc003yhu.1_Intron	NM_014754	NP_055569	P48651	PTSS1_HUMAN	phosphatidylserine synthase 1	128					phosphatidylserine biosynthetic process	integral to membrane	transferase activity			ovary(1)	1	Breast(36;6.18e-05)				Phosphatidylserine(DB00144)	CAGGTTAAATCTCTAATGTAT	0.433		NA											31	185					0	0	0	0
VPS13B	157680	broad.mit.edu	37	8	100779029	100779029	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr8:100779029G>A	uc003yiv.2	+	40	7264	c.7153G>A	c.(7153-7155)GAA>AAA	p.E2385K	VPS13B_uc003yiw.2_Missense_Mutation_p.E2360K	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	2385					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			ATACTGGGATGAACTCCAGAA	0.318		NA											14	36					0	0	0	0
FZD6	8323	broad.mit.edu	37	8	104337587	104337587	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr8:104337587G>C	uc003ylh.2	+	4	1537	c.1253G>C	c.(1252-1254)GGA>GCA	p.G418A	FZD6_uc003yli.2_Missense_Mutation_p.G418A|FZD6_uc003ylj.2_Missense_Mutation_p.G418A|FZD6_uc011lhn.1_Missense_Mutation_p.G384A|FZD6_uc011lho.1_Missense_Mutation_p.G113A|FZD6_uc011lhp.1_Missense_Mutation_p.G363A	NM_003506	NP_003497	O60353	FZD6_HUMAN	frizzled 6 isoform a precursor	418	Helical; Name=6; (Potential).				angiogenesis|axonogenesis|cell proliferation in midbrain|establishment of planar polarity|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|inner ear morphogenesis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|neural tube closure|non-canonical Wnt receptor signaling pathway	apical part of cell|apicolateral plasma membrane|cytoplasm|integral to plasma membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(57;2.86e-05)|STAD - Stomach adenocarcinoma(118;0.197)			ATTCGAATTGGAGTCTTCAGC	0.403		NA											26	157					0	0	0	0
TAF2	6873	broad.mit.edu	37	8	120809951	120809951	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr8:120809951C>T	uc003you.2	-	7	1198	c.928G>A	c.(928-930)GAT>AAT	p.D310N		NM_003184	NP_003175	Q6P1X5	TAF2_HUMAN	TBP-associated factor 2	310					G2/M transition of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor TFIID complex|transcription factor TFTC complex	metallopeptidase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			large_intestine(2)|ovary(2)|kidney(1)|skin(1)	6	Lung NSC(37;9.35e-07)|Ovarian(258;0.011)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			TAAGCCTCATCAATGAAGACA	0.353		NA											6	75					0	0	0	0
SNTB1	6641	broad.mit.edu	37	8	121823703	121823703	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr8:121823703G>C	uc010mdg.2	-	1	607	c.381C>G	c.(379-381)ATC>ATG	p.I127M	SNTB1_uc003ype.2_Missense_Mutation_p.I127M	NM_021021	NP_066301	Q13884	SNTB1_HUMAN	basic beta 1 syntrophin	127	PH 1.|PDZ.				muscle contraction	cell junction|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|calmodulin binding			skin(5)	5	Lung NSC(37;4.46e-09)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)		STAD - Stomach adenocarcinoma(47;0.00503)			TGCCCCCCTTGATGCTGATCC	0.632		NA											10	20					0	0	0	0
FLJ43860	389690	broad.mit.edu	37	8	142477621	142477621	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr8:142477621C>G	uc003ywi.2	-	18	2281	c.2200G>C	c.(2200-2202)GAG>CAG	p.E734Q	FLJ43860_uc011ljs.1_RNA|FLJ43860_uc010meu.1_RNA	NM_207414	NP_997297	Q6ZUA9	Q6ZUA9_HUMAN	hypothetical protein LOC389690	734							binding				0	all_cancers(97;7.79e-15)|all_epithelial(106;4.52e-13)|Lung NSC(106;2.07e-05)|all_lung(105;2.89e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			TCGCTCAACTCTGCCAGTGTG	0.667		NA											10	41					0	0	0	0
FOXD4	2298	broad.mit.edu	37	9	117889	117889	+	Silent	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr9:117889G>A	uc003zfz.2	-	1	529	c.231C>T	c.(229-231)AGC>AGT	p.S77S		NM_207305	NP_997188	Q12950	FOXD4_HUMAN	forkhead box D4	77					axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			skin(1)	1	all_lung(41;0.218)	all_cancers(5;0.0395)|Acute lymphoblastic leukemia(5;1.91e-07)|all_hematologic(5;1.95e-06)	Kidney(42;0.112)|KIRC - Kidney renal clear cell carcinoma(5;0.157)	all cancers(5;0.000704)|Lung(218;0.00755)|GBM - Glioblastoma multiforme(5;0.0149)|Epithelial(6;0.0154)		CTGAGGGGTCGCTCGGGCCGC	0.706		NA											26	105					0	0	0	0
SLC24A2	25769	broad.mit.edu	37	9	19619622	19619622	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr9:19619622G>C	uc003zoa.1	-	3	1100	c.1038C>G	c.(1036-1038)ATC>ATG	p.I346M	SLC24A2_uc003zob.1_Missense_Mutation_p.I346M	NM_020344	NP_065077	Q9UI40	NCKX2_HUMAN	solute carrier family 24	346	Cytoplasmic (Potential).				visual perception	integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			ovary(3)	3				GBM - Glioblastoma multiforme(1;1.67e-55)|Lung(42;0.0443)		TGAGTTGGAAGATGCTATTCC	0.507		NA											16	105					0	0	0	0
IFNA8	3445	broad.mit.edu	37	9	21409280	21409280	+	Silent	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr9:21409280G>A	uc003zpc.1	+	1	135	c.105G>A	c.(103-105)AGG>AGA	p.R35R		NM_002170	NP_002161	P32881	IFNA8_HUMAN	interferon, alpha 8 precursor	35					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding				0				Lung(24;7.66e-27)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.0174)		TGGGTAACAGGAGGGCCTTGA	0.498		NA											30	85					0	0	0	0
DNAJA1	3301	broad.mit.edu	37	9	33038791	33038791	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr9:33038791G>A	uc003zsd.1	+	9	1267	c.1084G>A	c.(1084-1086)GAA>AAA	p.E362K	DNAJA1_uc011lnt.1_Missense_Mutation_p.E205K	NM_001539	NP_001530	P31689	DNJA1_HUMAN	DnaJ (Hsp40) homolog, subfamily A, member 1	362					protein folding|response to heat|response to unfolded protein	membrane	ATP binding|heat shock protein binding|low-density lipoprotein particle receptor binding|metal ion binding|unfolded protein binding				0			LUSC - Lung squamous cell carcinoma(29;0.0227)	GBM - Glioblastoma multiforme(74;0.102)		GGACCAAGTAGAACTGGTGGA	0.468		NA											9	46					0	0	0	0
CCDC107	203260	broad.mit.edu	37	9	35660981	35660981	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr9:35660981G>A	uc011lox.1	+	5	715	c.649G>A	c.(649-651)GAG>AAG	p.E217K	RMRP_uc003zxh.1_5'Flank|CCDC107_uc011loy.1_Missense_Mutation_p.E190K|CCDC107_uc003zxj.2_3'UTR|CCDC107_uc003zxk.2_3'UTR|C9orf100_uc003zxl.2_Intron|C9orf100_uc003zxm.1_3'UTR	NM_174923	NP_777583	Q8WV48	CC107_HUMAN	coiled-coil domain containing 107 precursor	217						integral to membrane					0	all_epithelial(49;0.217)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			AAAGGAGGACGAGGAGGAGAT	0.557		NA											19	91					0	0	0	0
POLR1E	64425	broad.mit.edu	37	9	37486584	37486584	+	Silent	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr9:37486584C>T	uc003zzz.1	+	1	435	c.147C>T	c.(145-147)TTC>TTT	p.F49F	POLR1E_uc011lqj.1_Intron|POLR1E_uc003zzy.1_Intron|POLR1E_uc011lqk.1_Intron	NM_022490	NP_071935	Q9GZS1	RPA49_HUMAN	RNA polymerase I associated factor 53	49					rRNA transcription	cell junction|cytoplasm|nucleolus	DNA binding|DNA-directed RNA polymerase activity|protein binding				0				GBM - Glioblastoma multiforme(29;0.00851)|Lung(182;0.229)		ACCCGAGCTTCCTTGCCATCC	0.527		NA											9	11					0	0	0	0
FOXD4L5	653427	broad.mit.edu	37	9	70177786	70177786	+	Silent	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr9:70177786C>G	uc010moc.2	-	1	1030	c.198G>C	c.(196-198)GGG>GGC	p.G66G		NM_001126334	NP_001119806	Q5VV16	FX4L5_HUMAN	forkhead box D4-like 5	66					axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0						GAAGCGCAACCCCGCCCCACC	0.562		NA											7	85					0	0	0	0
C9orf71	169693	broad.mit.edu	37	9	71152191	71152191	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr9:71152191C>T	uc004agt.2	-	2	550	c.497G>A	c.(496-498)CGA>CAA	p.R166Q	uc004ags.1_RNA	NM_153237	NP_694969	Q8N6L7	CI071_HUMAN	hypothetical protein LOC169693	166						integral to membrane					0						CTCTTGGCCTCGCCTCTGGGC	0.562		NA											4	41					0	0	0	0
TRPM6	140803	broad.mit.edu	37	9	77354741	77354741	+	Silent	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr9:77354741G>A	uc004ajl.1	-	34	5623	c.5385C>T	c.(5383-5385)CTC>CTT	p.L1795L	TRPM6_uc004ajk.1_Silent_p.L1790L|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Silent_p.L746L|TRPM6_uc010mpd.1_Silent_p.L628L|TRPM6_uc010mpe.1_Silent_p.L342L|TRPM6_uc004ajj.1_Silent_p.L751L	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	1795	Alpha-type protein kinase.|Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						GTCCCGGCTTGAGAATGTCAT	0.507		NA											53	71					0	0	0	0
COL15A1	1306	broad.mit.edu	37	9	101765755	101765755	+	Silent	SNP	G	G	C	rs142437738		TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr9:101765755G>C	uc004azb.1	+	8	1292	c.1086G>C	c.(1084-1086)GCG>GCC	p.A362A		NM_001855	NP_001846	P39059	COFA1_HUMAN	alpha 1 type XV collagen precursor	362	Nonhelical region 1 (NC1).|1.|4 X tandem repeats.				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			ovary(6)	6		Acute lymphoblastic leukemia(62;0.0562)				CAACAGCAGCGGGGCTGGCCG	0.582		NA											16	76					0	0	0	0
ERP44	23071	broad.mit.edu	37	9	102769866	102769866	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr9:102769866C>T	uc004bam.2	-	9	1076	c.868G>A	c.(868-870)GAA>AAA	p.E290K	ERP44_uc010msy.2_RNA|ERP44_uc010msz.2_Missense_Mutation_p.E290K	NM_015051	NP_055866	Q9BS26	ERP44_HUMAN	thioredoxin domain containing 4 (endoplasmic	290					cell redox homeostasis|glycoprotein metabolic process|protein folding|response to unfolded protein	endoplasmic reticulum lumen|endoplasmic reticulum membrane|ER-Golgi intermediate compartment	protein binding|protein disulfide isomerase activity				0						CTACCTTTTTCACTTATTAAT	0.338		NA											12	42					0	0	0	0
KIAA0368	23392	broad.mit.edu	37	9	114134893	114134893	+	Silent	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr9:114134893G>A	uc004bfe.1	-	43	4878	c.4878C>T	c.(4876-4878)ATC>ATT	p.I1626I		NM_001080398	NP_001073867			KIAA0368 protein												0						AGGTCTTGTAGATAGGTTCTG	0.348		NA											4	22					0	0	0	0
ZFP37	7539	broad.mit.edu	37	9	115805660	115805660	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr9:115805660G>C	uc004bgm.1	-	4	1266	c.1238C>G	c.(1237-1239)TCT>TGT	p.S413C	ZFP37_uc011lwz.1_Missense_Mutation_p.S428C|ZFP37_uc011lxa.1_Missense_Mutation_p.S414C	NM_003408	NP_003399	Q9Y6Q3	ZFP37_HUMAN	zinc finger protein 37 homolog	413	C2H2-type 5.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						ATACCTAAAAGACTTCCCACA	0.393		NA											28	86					0	0	0	0
TRIM32	22954	broad.mit.edu	37	9	119460354	119460354	+	Silent	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr9:119460354C>T	uc004bjx.2	+	2	491	c.333C>T	c.(331-333)TTC>TTT	p.F111F	ASTN2_uc004bjr.1_Intron|ASTN2_uc004bjs.1_Intron|ASTN2_uc004bjt.1_Intron|TRIM32_uc004bjw.2_Silent_p.F111F	NM_001099679	NP_001093149	Q13049	TRI32_HUMAN	tripartite motif-containing 32	111	B box-type.				fat cell differentiation|innate immune response|negative regulation of apoptosis|negative regulation of fibroblast proliferation|positive regulation of cell cycle|positive regulation of cell growth|positive regulation of cell migration|positive regulation of neurogenesis|positive regulation of neuron differentiation|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein catabolic process|positive regulation of proteolysis|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to tumor necrosis factor|response to UV	nucleus	myosin binding|protein self-association|RNA binding|Tat protein binding|transcription coactivator activity|translation initiation factor binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(2)|kidney(1)	3						CCCGGCAATTCTGCCGGAGCT	0.592		NA							Bardet-Biedl_syndrome				18	74					0	0	0	0
ASTN2	23245	broad.mit.edu	37	9	119976688	119976688	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr9:119976688G>C	uc004bjs.1	-	3	1065	c.964C>G	c.(964-966)CTG>GTG	p.L322V	ASTN2_uc004bjr.1_Missense_Mutation_p.L322V|ASTN2_uc004bjt.1_Missense_Mutation_p.L322V	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	322	Cytoplasmic (Potential).					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						AGACTGTCCAGAGTGTGGGTC	0.552		NA											16	114					0	0	0	0
ANGPTL2	23452	broad.mit.edu	37	9	129851244	129851244	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr9:129851244G>A	uc004bqr.1	-	5	1956	c.1456C>T	c.(1456-1458)CGA>TGA	p.R486*	RALGPS1_uc004bqo.1_Intron|RALGPS1_uc011mab.1_Intron|RALGPS1_uc011mac.1_Intron|RALGPS1_uc004bqq.3_Intron|ANGPTL2_uc010mxg.1_Nonsense_Mutation_p.R184*	NM_012098	NP_036230	Q9UKU9	ANGL2_HUMAN	angiopoietin-like 2 precursor	486	Fibrinogen C-terminal.				multicellular organismal development|signal transduction	extracellular space	receptor binding				0						GGGTTCGGTCGGATCATCATC	0.607		NA											23	111					0	0	0	0
TTC16	158248	broad.mit.edu	37	9	130486622	130486622	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr9:130486622G>A	uc004brq.1	+	8	1163	c.1096G>A	c.(1096-1098)GGA>AGA	p.G366R	PTRH1_uc011mah.1_Intron|TTC16_uc011mai.1_Missense_Mutation_p.G353R|TTC16_uc004brr.1_Missense_Mutation_p.G311R|TTC16_uc010mxn.1_5'UTR	NM_144965	NP_659402	Q8NEE8	TTC16_HUMAN	tetratricopeptide repeat domain 16	366	TPR 7.						binding				0						GCAGGAGAAAGGACTCTACAT	0.662		NA											6	23					0	0	0	0
FPGS	2356	broad.mit.edu	37	9	130569916	130569916	+	Silent	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr9:130569916C>T	uc004bsg.1	+	8	743	c.693C>T	c.(691-693)CTC>CTT	p.L231L	FPGS_uc004bsh.1_Silent_p.L48L|FPGS_uc011mal.1_Silent_p.L205L|FPGS_uc004bsi.1_Silent_p.L181L	NM_004957	NP_004948	Q05932	FOLC_HUMAN	folylpolyglutamate synthase isoform a precursor	231					folic acid metabolic process|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|one-carbon metabolic process	cytosol|mitochondrial matrix	ATP binding|tetrahydrofolylpolyglutamate synthase activity				0					L-Glutamic Acid(DB00142)	ACACCAGCCTCCTGGGGGATA	0.488		NA											4	25					0	0	0	0
TRUB2	26995	broad.mit.edu	37	9	131084583	131084583	+	Silent	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr9:131084583C>G	uc004buq.1	-	1	115	c.105G>C	c.(103-105)CTG>CTC	p.L35L	COQ4_uc011max.1_5'Flank|COQ4_uc004bur.3_5'Flank|COQ4_uc004bus.2_5'Flank|COQ4_uc010mxy.2_5'Flank	NM_015679	NP_056494	O95900	TRUB2_HUMAN	TruB pseudouridine (psi) synthase homolog 2	35					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			ovary(1)	1						ACTCACCCTTCAGAAGTTGTA	0.562		NA											7	62					0	0	0	0
TOR1B	27348	broad.mit.edu	37	9	132566591	132566591	+	Missense_Mutation	SNP	C	C	T	rs78770065		TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr9:132566591C>T	uc004byk.1	+	2	499	c.439C>T	c.(439-441)CAT>TAT	p.H147Y		NM_014506	NP_055321	O14657	TOR1B_HUMAN	torsin family 1, member B (torsin B) precursor	147					chaperone mediated protein folding requiring cofactor|response to unfolded protein	endoplasmic reticulum lumen	ATP binding|nucleoside-triphosphatase activity|unfolded protein binding				0		Ovarian(14;0.0586)				GCACTTCCCTCATGAGCAGAA	0.483		NA											26	82					0	0	0	0
OLFM1	10439	broad.mit.edu	37	9	137990304	137990304	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr9:137990304G>C	uc010nar.2	+	4	945	c.629G>C	c.(628-630)AGA>ACA	p.R210T	OLFM1_uc004cfl.3_Missense_Mutation_p.R192T	NM_014279	NP_055094	Q99784	NOE1_HUMAN	olfactomedin related ER localized protein	210	Potential.				nervous system development	endoplasmic reticulum lumen	protein binding			ovary(1)|skin(1)	2		Myeloproliferative disorder(178;0.0333)		Epithelial(140;5.49e-08)|OV - Ovarian serous cystadenocarcinoma(145;9.68e-08)|all cancers(34;1.88e-07)		CTTCAGAGCAGAGTGTCCAAT	0.527		NA											15	56					0	0	0	0
NOTCH1	4851	broad.mit.edu	37	9	139402742	139402742	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr9:139402742C>T	uc004chz.2	-	20	3267	c.3267G>A	c.(3265-3267)TGG>TGA	p.W1089*	NOTCH1_uc004cia.1_Nonsense_Mutation_p.W319*	NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	1089	Extracellular (Potential).|EGF-like 28.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		AAAGGCCGGTCCAGCCGCTGG	0.652		NA	T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			31	64					0	0	0	0
TMEM141	85014	broad.mit.edu	37	9	139686222	139686222	+	Silent	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr9:139686222C>T	uc004cje.3	+	2	160	c.114C>T	c.(112-114)TTC>TTT	p.F38F	TMEM141_uc011meg.1_Silent_p.F38F	NM_032928	NP_116317	Q96I45	TM141_HUMAN	transmembrane protein 141	38	Helical; (Potential).					integral to membrane					0	all_cancers(76;0.0882)|all_epithelial(76;0.228)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;8.67e-06)|Epithelial(140;0.000112)		TTTTCACCTTCGTCACAGGTA	0.672		NA									OREG0019622	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	32	49					0	0	0	0
MRPL41	64975	broad.mit.edu	37	9	140446891	140446891	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr9:140446891G>C	uc004cnh.3	+	2	488	c.358G>C	c.(358-360)GAG>CAG	p.E120Q	PNPLA7_uc010ncj.1_5'Flank|PNPLA7_uc004cnf.2_5'Flank	NM_032477	NP_115866	Q8IXM3	RM41_HUMAN	mitochondrial ribosomal protein L41	120					apoptosis|cell cycle|translation	mitochondrial large ribosomal subunit	structural constituent of ribosome				0	all_cancers(76;0.106)			OV - Ovarian serous cystadenocarcinoma(145;0.000415)|Epithelial(140;0.00106)		GTACGGCTTCGAGCCCACACA	0.602		NA											11	23					0	0	0	0
EHMT1	79813	broad.mit.edu	37	9	140622883	140622883	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr9:140622883C>G	uc011mfc.1	+	4	762	c.725C>G	c.(724-726)TCT>TGT	p.S242C	EHMT1_uc004coa.2_Missense_Mutation_p.S242C|EHMT1_uc004cob.1_Missense_Mutation_p.S211C	NM_024757	NP_079033	Q9H9B1	EHMT1_HUMAN	euchromatic histone-lysine N-methyltransferase 1	242					DNA methylation|embryo development|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			breast(2)|pancreas(1)	3	all_cancers(76;0.164)			OV - Ovarian serous cystadenocarcinoma(145;0.000183)|Epithelial(140;0.000728)		AAAAACATTTCTGACTTTGGA	0.458		NA											11	85					0	0	0	0
ARHGAP6	395	broad.mit.edu	37	X	11187648	11187648	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chrX:11187648C>T	uc004cup.1	-	9	2659	c.1786G>A	c.(1786-1788)GAA>AAA	p.E596K	ARHGAP6_uc004cuo.1_RNA|ARHGAP6_uc004cur.1_Missense_Mutation_p.E596K|ARHGAP6_uc004cum.1_Missense_Mutation_p.E393K|ARHGAP6_uc004cun.1_Missense_Mutation_p.E416K|ARHGAP6_uc010neb.1_Missense_Mutation_p.E418K|ARHGAP6_uc011mif.1_Missense_Mutation_p.E393K	NM_013427	NP_038286	O43182	RHG06_HUMAN	Rho GTPase activating protein 6 isoform 1	596	Rho-GAP.				actin filament polymerization|activation of phospholipase C activity|negative regulation of focal adhesion assembly|negative regulation of stress fiber assembly|Rho protein signal transduction	actin filament|cytosol	phospholipase activator activity|phospholipase binding|Rho GTPase activator activity|SH3 domain binding|SH3/SH2 adaptor activity			urinary_tract(1)|lung(1)	2						TCATAATTTTCAATCATCTTT	0.488		NA											14	45					0	0	0	0
PRPS2	5634	broad.mit.edu	37	X	12837668	12837668	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chrX:12837668G>C	uc004cvb.2	+	5	697	c.573G>C	c.(571-573)TTG>TTC	p.L191F	PRPS2_uc004cva.2_Missense_Mutation_p.L194F|PRPS2_uc010nec.2_Intron	NM_002765	NP_002756	P11908	PRPS2_HUMAN	phosphoribosyl pyrophosphate synthetase 2	191					nucleoside metabolic process|ribonucleoside monophosphate biosynthetic process		ATP binding|kinase activity|magnesium ion binding|protein homodimerization activity|ribose phosphate diphosphokinase activity				0						AATTTGCTTTGATCCACAAAG	0.488		NA											36	120					0	0	0	0
DMD	1756	broad.mit.edu	37	X	31986604	31986604	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chrX:31986604G>T	uc004dda.1	-	45	6710	c.6466C>A	c.(6466-6468)CAA>AAA	p.Q2156K	DMD_uc004dcr.1_5'UTR|DMD_uc004dcs.1_5'UTR|DMD_uc004dct.1_5'UTR|DMD_uc004dcu.1_5'UTR|DMD_uc004dcv.1_5'UTR|DMD_uc004dcw.2_Missense_Mutation_p.Q812K|DMD_uc004dcx.2_Missense_Mutation_p.Q815K|DMD_uc004dcz.2_Missense_Mutation_p.Q2033K|DMD_uc004dcy.1_Missense_Mutation_p.Q2152K|DMD_uc004ddb.1_Missense_Mutation_p.Q2148K|DMD_uc010ngo.1_Missense_Mutation_p.Q65K|DMD_uc010ngn.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	2156	Spectrin 15.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				ACAACAGTTTGCCGCTGCCCA	0.393		NA											20	53					1.38e-19	1.5e-19	1	0
SYTL5	94122	broad.mit.edu	37	X	37969686	37969686	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chrX:37969686C>T	uc004ddu.2	+	14	2081	c.1547C>T	c.(1546-1548)TCA>TTA	p.S516L	SYTL5_uc004ddv.2_Missense_Mutation_p.S516L|SYTL5_uc004ddx.2_Missense_Mutation_p.S538L	NM_001163335	NP_001156807	Q8TDW5	SYTL5_HUMAN	synaptotagmin-like 5 isoform 1	516					intracellular protein transport	membrane	metal ion binding|Rab GTPase binding			skin(1)	1						CCTTTTGACTCATGGAACTTT	0.438		NA											18	113					0	0	0	0
PAGE5	90737	broad.mit.edu	37	X	55247872	55247872	+	Silent	SNP	T	T	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chrX:55247872T>C	uc004duj.2	+	2	359	c.117T>C	c.(115-117)TCT>TCC	p.S39S	PAGE5_uc004duk.2_Silent_p.S19S	NM_130467	NP_569734	Q96GU1	GGEE1_HUMAN	P antigen family, member 5 isoform 1	39											0						ACCAAGAGTCTTCCCAGCCAG	0.348		NA											25	53					0	0	0	0
SPIN4	139886	broad.mit.edu	37	X	62570191	62570191	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chrX:62570191C>T	uc004dvf.2	-	1	1028	c.508G>A	c.(508-510)GAC>AAC	p.D170N		NM_001012968	NP_001012986	Q56A73	SPIN4_HUMAN	spindlin family, member 4	170					gamete generation					ovary(1)|lung(1)	2						TCTTTGTAGTCATCAAGCAGC	0.478		NA											25	91					0	0	0	0
LPAR4	2846	broad.mit.edu	37	X	78010707	78010707	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chrX:78010707C>G	uc010nme.2	+	2	746	c.341C>G	c.(340-342)TCT>TGT	p.S114C		NM_005296	NP_005287	Q99677	LPAR4_HUMAN	lysophosphatidic acid receptor 4	114	Helical; Name=3; (Potential).					integral to plasma membrane	lipid binding|purinergic nucleotide receptor activity, G-protein coupled			ovary(3)	3						TGCAAGATCTCTGGAACTGCA	0.433		NA											27	121					0	0	0	0
P2RY10	27334	broad.mit.edu	37	X	78216233	78216233	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chrX:78216233C>G	uc004ede.2	+	4	585	c.216C>G	c.(214-216)TTC>TTG	p.F72L	P2RY10_uc004edf.2_Missense_Mutation_p.F72L	NM_014499	NP_055314	O00398	P2Y10_HUMAN	G-protein coupled purinergic receptor P2Y10	72	Helical; Name=2; (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(2)|lung(2)|breast(1)	5						CCATCATTTTCATGATCAACC	0.458		NA											12	101					0	0	0	0
NAP1L3	4675	broad.mit.edu	37	X	92928297	92928297	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chrX:92928297C>G	uc004efq.2	-	1	312	c.7G>C	c.(7-9)GAA>CAA	p.E3Q	FAM133A_uc004efr.1_5'Flank	NM_004538	NP_004529	Q99457	NP1L3_HUMAN	nucleosome assembly protein 1-like 3	3					nucleosome assembly	chromatin assembly complex				ovary(1)|skin(1)	2						AAATCTGCTTCTGCCATCTTG	0.453		NA											17	55					0	0	0	0
CENPI	2491	broad.mit.edu	37	X	100382652	100382652	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chrX:100382652G>C	uc004egx.2	+	10	1342	c.1072G>C	c.(1072-1074)GAG>CAG	p.E358Q	CENPI_uc011mrg.1_Missense_Mutation_p.E358Q|CENPI_uc004egy.2_Missense_Mutation_p.E358Q	NM_006733	NP_006724	Q92674	CENPI_HUMAN	centromere protein I	358					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	cytosol|kinetochore|nucleoplasm	protein binding			skin(1)	1						CCATTGCTTAGAGGTATGTGA	0.299		NA											41	103					0	0	0	0
DRP2	1821	broad.mit.edu	37	X	100505953	100505953	+	Silent	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chrX:100505953C>T	uc004egz.2	+	16	2115	c.1746C>T	c.(1744-1746)GTC>GTT	p.V582V	DRP2_uc011mrh.1_Silent_p.V504V	NM_001939	NP_001930	Q13474	DRP2_HUMAN	dystrophin related protein 2	582					central nervous system development	cytoplasm|cytoskeleton	zinc ion binding			ovary(2)	2						TGGAGTGGGTCAACCTGGAGC	0.537		NA											23	98					0	0	0	0
ARMCX2	9823	broad.mit.edu	37	X	100911314	100911314	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chrX:100911314G>A	uc004eid.2	-	3	1616	c.1261C>T	c.(1261-1263)CAA>TAA	p.Q421*	ARMCX2_uc004eie.3_Nonsense_Mutation_p.Q421*|ARMCX2_uc004eif.3_Nonsense_Mutation_p.Q421*|ARMCX2_uc004eig.3_Nonsense_Mutation_p.Q421*|ARMCX2_uc010nnt.2_Nonsense_Mutation_p.Q421*	NM_177949	NP_808818	Q7L311	ARMX2_HUMAN	ALEX2 protein	421	ARM 2.					integral to membrane	binding			ovary(6)	6						ATTGTCTCTTGATTGCATGAA	0.413		NA											20	68					0	0	0	0
BHLHB9	80823	broad.mit.edu	37	X	102004986	102004986	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chrX:102004986C>T	uc010nog.2	+	4	1634	c.1063C>T	c.(1063-1065)CCA>TCA	p.P355S	BHLHB9_uc011mrq.1_Missense_Mutation_p.P355S|BHLHB9_uc011mrr.1_Missense_Mutation_p.P355S|BHLHB9_uc011mrs.1_Missense_Mutation_p.P355S|BHLHB9_uc011mrt.1_Missense_Mutation_p.P355S|BHLHB9_uc004ejo.2_Missense_Mutation_p.P355S|BHLHB9_uc011mru.1_Missense_Mutation_p.P355S|BHLHB9_uc011mrv.1_Missense_Mutation_p.P355S	NM_001142526	NP_001135998	Q6PI77	BHLH9_HUMAN	basic helix-loop-helix domain containing, class	355						cytoplasm|nucleus	binding			ovary(2)	2						TAATGTTCACCCATTTGCCCA	0.363		NA											5	73					0	0	0	0
ESX1	80712	broad.mit.edu	37	X	103498857	103498857	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chrX:103498857G>A	uc004ely.2	-	2	542	c.484C>T	c.(484-486)CAA>TAA	p.Q162*		NM_153448	NP_703149	Q8N693	ESX1_HUMAN	extraembryonic, spermatogenesis, homeobox	162	Homeobox.				negative regulation of transcription, DNA-dependent|regulation of cell cycle	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TCGGGATATTGAGATTCATCG	0.612		NA											22	70					0	0	0	0
IRS4	8471	broad.mit.edu	37	X	107976960	107976960	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chrX:107976960G>A	uc004eoc.2	-	1	2648	c.2615C>T	c.(2614-2616)TCA>TTA	p.S872L		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	872						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						CTTTGAAGGTGATCCCCCATC	0.443		NA											58	201					0	0	0	0
IRS4	8471	broad.mit.edu	37	X	107976981	107976981	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chrX:107976981G>A	uc004eoc.2	-	1	2627	c.2594C>T	c.(2593-2595)TCA>TTA	p.S865L		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	865						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						TCCAGGCTTTGAGAATGATCC	0.468		NA											60	212					0	0	0	0
WDR44	54521	broad.mit.edu	37	X	117526862	117526862	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chrX:117526862G>C	uc004eqn.2	+	4	879	c.454G>C	c.(454-456)GAT>CAT	p.D152H	WDR44_uc004eqo.2_Missense_Mutation_p.D152H|WDR44_uc011mtr.1_Missense_Mutation_p.D127H|WDR44_uc010nqi.2_5'UTR	NM_019045	NP_061918	Q5JSH3	WDR44_HUMAN	WD repeat domain 44 protein	152	Potential.|Binding activity.					cytosol|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm				lung(2)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	5						GAAACCAGTAGATGAAACCAC	0.378		NA											25	91					0	0	0	0
SASH3	54440	broad.mit.edu	37	X	128926786	128926786	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chrX:128926786G>A	uc011mun.1	+	6	957	c.775G>A	c.(775-777)GAG>AAG	p.E259K	SASH3_uc004euu.2_Missense_Mutation_p.E259K|SASH3_uc011muo.1_Missense_Mutation_p.E226K	NM_018990	NP_061863	O75995	SASH3_HUMAN	SAM and SH3 domain containing 3	259	SAM.									ovary(2)|pancreas(1)	3						GACCCTGCATGAGCTGCTGGA	0.607		NA											13	15					0	0	0	0
GPR101	83550	broad.mit.edu	37	X	136113291	136113291	+	Silent	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chrX:136113291G>C	uc011mwh.1	-	1	543	c.543C>G	c.(541-543)CTC>CTG	p.L181L		NM_054021	NP_473362	Q96P66	GP101_HUMAN	G protein-coupled receptor 101	181	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	Acute lymphoblastic leukemia(192;0.000127)					TCATGGAGCAGAGAGCATTGC	0.572		NA											11	22					0	0	0	0
FMR1NB	158521	broad.mit.edu	37	X	147084799	147084799	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chrX:147084799A>T	uc004fcm.2	+	2	430	c.356A>T	c.(355-357)GAT>GTT	p.D119V		NM_152578	NP_689791	Q8N0W7	FMR1N_HUMAN	fragile X mental retardation 1 neighbor	119	Extracellular (Potential).					integral to membrane				ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					CTGGAAGAAGATTCCGCATTG	0.353		NA											26	62					0	0	0	0
MAGEA8	4107	broad.mit.edu	37	X	149013285	149013285	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chrX:149013285G>C	uc004fdw.1	+	3	454	c.239G>C	c.(238-240)TGG>TCG	p.W80S		NM_005364	NP_005355	P43361	MAGA8_HUMAN	melanoma antigen family A, 8	80											0	Acute lymphoblastic leukemia(192;6.56e-05)					AGCACTCTGTGGAGCCAATCC	0.597		NA											14	52					0	0	0	0
ABCD1	215	broad.mit.edu	37	X	153006073	153006073	+	Silent	SNP	G	G	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chrX:153006073G>A	uc004fif.2	+	7	2079	c.1680G>A	c.(1678-1680)CCG>CCA	p.P560P	ABCD1_uc004fig.2_Silent_p.P60P|ABCD1_uc004fih.2_5'Flank	NM_000033	NP_000024	P33897	ABCD1_HUMAN	ATP-binding cassette, sub-family D (ALD), member	560	ABC transporter.		P -> S (in X-ALD).|P -> L (in X-ALD; CALD-type).|P -> R (in X-ALD; AMN and ALMD-types).		fatty acid beta-oxidation using acyl-CoA oxidase|peroxisomal membrane transport|peroxisome organization	cytosol|integral to peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|identical protein binding|peroxisomal fatty-acyl-CoA transporter activity				0	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TGATCTACCCGGACTCAGTGG	0.637		NA											15	54					0	0	0	0
FAM50A	9130	broad.mit.edu	37	X	153677638	153677638	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chrX:153677638G>C	uc004fll.3	+	8	816	c.718G>C	c.(718-720)GAG>CAG	p.E240Q		NM_004699	NP_004690	Q14320	FA50A_HUMAN	XAP-5 protein	240					spermatogenesis	nucleus				ovary(1)	1	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					AGACTTCAGTGAGCTGAGGTG	0.592		NA											11	33					0	0	0	0
NOTCH2	4853	broad.mit.edu	37	1	120480487	120480487	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr1:120480487delG	uc001eik.2	-	20	3586	c.3330delC	c.(3328-3330)TCCfs	p.S1110fs	NOTCH2_uc001eil.2_Frame_Shift_Del_p.S1110fs	NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	1110	EGF-like 29.|Extracellular (Potential).				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		TACCTCTCCTGGAGGCTGCTA	0.483		NA	N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				14	43	---	---	---	---	NA	NA	NA	NA
IFT81	28981	broad.mit.edu	37	12	110628806	110628806	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr12:110628806delG	uc001tqi.2	+	13	1550	c.1420delG	c.(1420-1422)GAAfs	p.E474fs	IFT81_uc001tqh.2_Frame_Shift_Del_p.E474fs|IFT81_uc001tqj.2_RNA	NM_001143779	NP_001137251	Q8WYA0	IFT81_HUMAN	intraflagellar transport 81-like isoform 1	474					cell differentiation|multicellular organismal development|spermatogenesis	intraflagellar transport particle B|microtubule-based flagellum				ovary(1)	1						ACTGAAGAGTGAAGTTGATGA	0.333		NA											34	76	---	---	---	---	NA	NA	NA	NA
LONP2	83752	broad.mit.edu	37	16	48286135	48286135	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr16:48286135delG	uc002efi.1	+	2	416	c.327delG	c.(325-327)CAGfs	p.Q109fs	LONP2_uc010vgm.1_RNA|LONP2_uc002efj.1_Frame_Shift_Del_p.Q109fs	NM_031490	NP_113678	Q86WA8	LONP2_HUMAN	peroxisomal LON protease-like	109	Lon.				misfolded or incompletely synthesized protein catabolic process|protein targeting to peroxisome|signal peptide processing	nucleoid|peroxisomal matrix	ATP binding|ATP-dependent peptidase activity|enzyme binding|sequence-specific DNA binding|serine-type endopeptidase activity				0						GCCGTTTCCAGATTGTACAGG	0.507		NA											14	30	---	---	---	---	NA	NA	NA	NA
RAP1GAP2	23108	broad.mit.edu	37	17	2930332	2930332	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr17:2930332delC	uc010ckd.2	+	22	2165	c.2075delC	c.(2074-2076)GCCfs	p.A692fs	RAP1GAP2_uc010cke.2_Frame_Shift_Del_p.A677fs	NM_015085	NP_055900	Q684P5	RPGP2_HUMAN	RAP1 GTPase activating protein 2 isoform 1	692	Ser-rich.				regulation of small GTPase mediated signal transduction	centrosome|cytosol|perinuclear region of cytoplasm	GTPase activator activity			ovary(1)	1						GGGGCAGCTGCCACCCCGATC	0.647		NA											2	4	---	---	---	---	NA	NA	NA	NA
TMPRSS15	5651	broad.mit.edu	37	21	19725330	19725331	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr21:19725330_19725331insA	uc002ykw.2	-	10	1091_1092	c.1060_1061insT	c.(1060-1062)TGTfs	p.C354fs		NM_002772	NP_002763	P98073	ENTK_HUMAN	enterokinase precursor	354	Extracellular (Potential).|MAM.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity	p.C354F(1)		ovary(5)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	8						GACCCAGAAACAAAAGCCATCC	0.332		NA											27	93	---	---	---	---	NA	NA	NA	NA
FAT1	2195	broad.mit.edu	37	4	187549762	187549763	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CV-7427-01A-11D-2078-08	TCGA-CV-7427-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3fdb4698-4a38-4a81-a403-d1ce5568c225	01aea99d-e331-4b02-a0cd-e9df66a08d9c	g.chr4:187549762_187549763insA	uc003izf.2	-	8	4666_4667	c.4478_4479insT	c.(4477-4479)CTGfs	p.L1493fs		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	1493	Extracellular (Potential).|Cadherin 13.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						TACTGCTCTGCAGAGTGTAGAT	0.416		NA								HNSCC(5;0.00058)			12	48	---	---	---	---	NA	NA	NA	NA