Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
SPEN	23013	broad.mit.edu	37	1	16257698	16257698	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr1:16257698G>C	uc001axk.1	+	11	5167	c.4963G>C	c.(4963-4965)GAG>CAG	p.E1655Q	SPEN_uc010obp.1_Missense_Mutation_p.E1614Q	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	1655					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		ATCAGCACTAGAGAAGACCAC	0.493		NA											9	146					0	0	0	0
BEND7	222389	broad.mit.edu	37	10	13481367	13481367	+	Silent	SNP	G	G	C			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr10:13481367G>C	uc001imm.2	-	9	1509	c.1212C>G	c.(1210-1212)CTC>CTG	p.L404L	BEND7_uc001iml.2_RNA	NM_152751	NP_689964	Q8N7W2	BEND7_HUMAN	BEN domain containing 7 isoform 1	455							protein binding			ovary(1)|breast(1)	2						TCAGGAGCACGAGATGCTGCT	0.493		NA											4	38					0	0	0	0
OR5D14	219436	broad.mit.edu	37	11	55563470	55563470	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr11:55563470G>T	uc010rim.1	+	1	439	c.439G>T	c.(439-441)GTG>TTG	p.V147L		NM_001004735	NP_001004735	Q8NGL3	OR5DE_HUMAN	olfactory receptor, family 5, subfamily D,	147	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3		all_epithelial(135;0.196)				TGCCCTGCTGGTGGCTGGGTC	0.507		NA											6	65					3.6e-05	3.88e-05	1	0
OR5D18	219438	broad.mit.edu	37	11	55587255	55587255	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr11:55587255C>G	uc010rin.1	+	1	150	c.150C>G	c.(148-150)ATC>ATG	p.I50M		NM_001001952	NP_001001952	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D,	50	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.208)				TTGTGATCATCAAAATCAACC	0.453		NA											8	106					0	0	0	0
IGHMBP2	3508	broad.mit.edu	37	11	68703725	68703725	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr11:68703725G>A	uc001ook.1	+	13	1879	c.1777G>A	c.(1777-1779)GAG>AAG	p.E593K	IGHMBP2_uc001ool.1_Missense_Mutation_p.E217K|IGHMBP2_uc001oom.1_Missense_Mutation_p.E171K	NM_002180	NP_002171	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	593					cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			TTTTCTTGCTGAGGACCGGAG	0.532		NA											14	99					0	0	0	0
GYS2	2998	broad.mit.edu	37	12	21728963	21728963	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr12:21728963C>T	uc001rfb.2	-	3	587	c.332G>A	c.(331-333)GGA>GAA	p.G111E		NM_021957	NP_068776	P54840	GYS2_HUMAN	glycogen synthase 2	111					glucose metabolic process|glycogen biosynthetic process|response to glucose stimulus	cortical actin cytoskeleton|cytosol|ectoplasm|insoluble fraction|soluble fraction	glycogen (starch) synthase activity|protein homodimerization activity			lung(1)|skin(1)	2						ATAAGGACTTCCTTCTATCAG	0.433		NA											4	54					0	0	0	0
LARP4	113251	broad.mit.edu	37	12	50869453	50869453	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr12:50869453G>T	uc001rwp.1	+	16	2125	c.1981G>T	c.(1981-1983)GTT>TTT	p.V661F	LARP4_uc001rwo.1_Missense_Mutation_p.V667F|LARP4_uc001rwq.1_Missense_Mutation_p.V590F|LARP4_uc001rwr.1_Missense_Mutation_p.V590F|LARP4_uc001rws.1_Missense_Mutation_p.V660F|LARP4_uc009zlr.1_Missense_Mutation_p.V460F|LARP4_uc001rwt.1_Missense_Mutation_p.V252F	NM_052879	NP_443111	Q71RC2	LARP4_HUMAN	c-Mpl binding protein isoform a	661							nucleotide binding|RNA binding			ovary(1)	1						TGAGAACTCCGTTGAGAAACC	0.488		NA											8	110					5.18e-06	5.72e-06	1	0
IRAK3	11213	broad.mit.edu	37	12	66641854	66641854	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr12:66641854C>G	uc001sth.2	+	12	1796	c.1694C>G	c.(1693-1695)TCA>TGA	p.S565*	IRAK3_uc010ssy.1_Nonsense_Mutation_p.S504*	NM_007199	NP_009130	Q9Y616	IRAK3_HUMAN	interleukin-1 receptor-associated kinase 3	565					interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|negative regulation of innate immune response|negative regulation of interleukin-12 production|negative regulation of interleukin-6 production|negative regulation of macrophage cytokine production|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein catabolic process|negative regulation of protein complex disassembly|negative regulation of toll-like receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of macrophage tolerance induction|positive regulation of NF-kappaB transcription factor activity|response to exogenous dsRNA|response to lipopolysaccharide|response to peptidoglycan	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein heterodimerization activity|protein homodimerization activity|protein serine/threonine kinase activity			lung(3)|ovary(2)|breast(2)|central_nervous_system(1)	8				GBM - Glioblastoma multiforme(28;0.0203)		GATCCTTCTTCAGAAGCTCCA	0.423		NA											5	84					0	0	0	0
PCDH9	5101	broad.mit.edu	37	13	67801363	67801363	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr13:67801363C>T	uc001vik.2	-	2	1902	c.1210G>A	c.(1210-1212)GAA>AAA	p.E404K	PCDH9_uc001vil.2_Missense_Mutation_p.E404K|PCDH9_uc010thl.1_Missense_Mutation_p.E404K|PCDH9_uc001vin.3_Missense_Mutation_p.E404K	NM_203487	NP_982354	Q9HC56	PCDH9_HUMAN	protocadherin 9 isoform 1 precursor	404	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)|skin(1)	6		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		ACCTCTCTTTCAATAAAACAG	0.378		NA											5	70					0	0	0	0
MESDC1	59274	broad.mit.edu	37	15	81295191	81295191	+	Silent	SNP	C	C	T			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr15:81295191C>T	uc002bfz.2	+	1	1897	c.579C>T	c.(577-579)TTC>TTT	p.F193F		NM_022566	NP_072088	Q9H1K6	MESD1_HUMAN	mesoderm development candidate 1	193											0						ACCTCAAGTTCCTGACGGACG	0.682		NA											3	10					0	0	0	0
FSD2	123722	broad.mit.edu	37	15	83447594	83447594	+	Silent	SNP	T	T	C			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr15:83447594T>C	uc002bjd.2	-	6	1202	c.1035A>G	c.(1033-1035)GCA>GCG	p.A345A	FSD2_uc010uol.1_Silent_p.A345A|FSD2_uc010uom.1_Silent_p.A345A	NM_001007122	NP_001007123	A1L4K1	FSD2_HUMAN	fibronectin type III and SPRY domain containing	345										central_nervous_system(1)	1						ACTCAGGCTGTGCAGAGATTT	0.468		NA											3	31					0	0	0	0
ACAN	176	broad.mit.edu	37	15	89395139	89395139	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr15:89395139T>C	uc010upo.1	+	11	2515	c.2141T>C	c.(2140-2142)GTA>GCA	p.V714A	ACAN_uc010upp.1_Missense_Mutation_p.V714A|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	714					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			GCTGTCCCCGTAGAAGAGGAG	0.567		NA											2	10					0	0	0	0
XYLT1	64131	broad.mit.edu	37	16	17211720	17211720	+	Silent	SNP	C	C	T			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr16:17211720C>T	uc002dfa.2	-	11	2425	c.2340G>A	c.(2338-2340)GTG>GTA	p.V780V		NM_022166	NP_071449	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	780	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			ovary(4)	4						AAATGACGGTCACGGTCACAT	0.552		NA											4	44					0	0	0	0
ATP2C2	9914	broad.mit.edu	37	16	84488581	84488581	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr16:84488581C>G	uc002fhx.2	+	21	2227	c.2138C>G	c.(2137-2139)TCA>TGA	p.S713*	ATP2C2_uc010chj.2_Nonsense_Mutation_p.S713*|ATP2C2_uc002fhy.2_Nonsense_Mutation_p.S730*|ATP2C2_uc002fhz.2_Nonsense_Mutation_p.S562*	NM_014861	NP_055676	O75185	AT2C2_HUMAN	ATPase, Ca++ transporting, type 2C, member 2	713	Extracellular (Potential).				ATP biosynthetic process	Golgi membrane|integral to membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)	2						GATGACTTCTCAGCCATCATG	0.552		NA											4	39					0	0	0	0
ANKRD40	91369	broad.mit.edu	37	17	48777098	48777098	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr17:48777098C>T	uc002iso.2	-	3	695	c.440G>A	c.(439-441)GGC>GAC	p.G147D		NM_052855	NP_443087	Q6AI12	ANR40_HUMAN	ankyrin repeat domain 40	147											0			BRCA - Breast invasive adenocarcinoma(22;2.03e-09)			TGTGGAGGGGCCCCCATTCTG	0.587		NA											4	61					0	0	0	0
PNPT1	87178	broad.mit.edu	37	2	55894995	55894995	+	Splice_Site	SNP	A	A	G			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr2:55894995A>G	uc002rzf.2	-	12	1126	c.1073_splice	c.e12+1	p.R358_splice	PNPT1_uc002rzg.2_Splice_Site	NM_033109	NP_149100	Q8TCS8	PNPT1_HUMAN	polyribonucleotide nucleotidyltransferase 1						mRNA catabolic process|RNA processing	plasma membrane	3'-5'-exoribonuclease activity|polyribonucleotide nucleotidyltransferase activity|RNA binding				0			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			GGGTATGTTTACCTTTTGTAT	0.308		NA											2	11					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179635016	179635016	+	Silent	SNP	C	C	G			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr2:179635016C>G	uc010zfg.1	-	36	8636	c.8412G>C	c.(8410-8412)GTG>GTC	p.V2804V	TTN_uc010zfh.1_Silent_p.V2758V|TTN_uc010zfi.1_Silent_p.V2758V|TTN_uc010zfj.1_Silent_p.V2758V|TTN_uc002unb.2_Silent_p.V2804V	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	2804							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCAAGGCTGTCACATCCTTTG	0.408		NA											6	69					0	0	0	0
SPP2	6694	broad.mit.edu	37	2	234975872	234975872	+	Silent	SNP	C	C	T			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr2:234975872C>T	uc002vvk.1	+	6	589	c.504C>T	c.(502-504)CTC>CTT	p.L168L	SPP2_uc010fyl.1_Silent_p.L88L	NM_006944	NP_008875	Q13103	SPP24_HUMAN	secreted phosphoprotein 2, 24kDa precursor	168					bone remodeling|skeletal system development	extracellular region	endopeptidase inhibitor activity				0		Breast(86;0.0109)|Renal(207;0.019)|all_lung(227;0.13)|all_hematologic(139;0.182)		Epithelial(121;5.73e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000166)|Lung(119;0.00539)|LUSC - Lung squamous cell carcinoma(224;0.00846)		TTACAGGTCTCATTTCAGACG	0.393		NA											7	84					0	0	0	0
ALS2CL	259173	broad.mit.edu	37	3	46730899	46730899	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr3:46730899C>T	uc003cqa.1	-	2	222	c.32G>A	c.(31-33)CGG>CAG	p.R11Q	ALS2CL_uc003cqb.1_Missense_Mutation_p.R11Q|ALS2CL_uc003cqc.1_RNA	NM_147129	NP_667340	Q60I27	AL2CL_HUMAN	ALS2 C-terminal like isoform 1	11					endosome organization|regulation of Rho protein signal transduction		GTPase activator activity|identical protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000726)|KIRC - Kidney renal clear cell carcinoma(197;0.0171)|Kidney(197;0.0202)		CTCCTCCAGCCGCAGCAGAGC	0.622		NA											3	10					0	0	0	0
RHOA	387	broad.mit.edu	37	3	49412905	49412905	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr3:49412905C>G	uc003cwu.2	-	2	394	c.118G>C	c.(118-120)GAG>CAG	p.E40Q	RHOA_uc010hku.2_5'UTR	NM_001664	NP_001655	P61586	RHOA_HUMAN	ras homolog gene family, member A precursor	40	Effector region (Potential).				axon guidance|interspecies interaction between organisms|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of axonogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of neuron differentiation|positive regulation of NF-kappaB import into nucleus|positive regulation of stress fiber assembly|regulation of cell migration|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|spindle assembly involved in mitosis	cytoskeleton|cytosol|plasma membrane	GTP binding|GTPase activity|myosin binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;8.58e-05)|Kidney(197;0.0023)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)	Atorvastatin(DB01076)|Simvastatin(DB00641)	ACATAGTTCTCAAACACTGTG	0.438		NA											11	78					0	0	0	0
MCM2	4171	broad.mit.edu	37	3	127335797	127335797	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr3:127335797G>A	uc003ejp.2	+	10	1666	c.1609G>A	c.(1609-1611)GAG>AAG	p.E537K	MCM2_uc011bkm.1_Missense_Mutation_p.E407K|MCM2_uc010hsl.2_RNA|MCM2_uc011bkn.1_Missense_Mutation_p.E490K	NM_004526	NP_004517	P49736	MCM2_HUMAN	minichromosome maintenance complex component 2	537	MCM.				cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|helicase activity|metal ion binding			ovary(3)|skin(1)	4						CAAGTATATTGAGAAAGTGTC	0.597		NA											6	117					0	0	0	0
PIK3CA	5290	broad.mit.edu	37	3	178936091	178936091	+	Missense_Mutation	SNP	G	G	A	rs104886003		TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			5	21					0	0	0	0
SMR3B	10879	broad.mit.edu	37	4	71255552	71255552	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr4:71255552C>A	uc011cas.1	+	3	308	c.227C>A	c.(226-228)CCT>CAT	p.P76H	SMR3B_uc003hfh.2_Missense_Mutation_p.P76H	NM_006685	NP_006676	P02814	SMR3B_HUMAN	submaxillary gland androgen regulated protein 3	76	Poly-Pro.|Pro-rich.					extracellular space				skin(1)	1		all_hematologic(202;0.196)				CCACCACCCCCTCCTCAACCC	0.582		NA											6	89					3.6e-05	3.88e-05	1	0
CDH10	1008	broad.mit.edu	37	5	24487840	24487840	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr5:24487840C>G	uc003jgr.1	-	12	2631	c.2299G>C	c.(2299-2301)GAA>CAA	p.E767Q	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	767	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		GGGCCCCATTCTCGGAGGTAA	0.413		NA								HNSCC(23;0.051)			6	118					0	0	0	0
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	5	139909243	139909243	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr5:139909243G>T	uc003lfs.1	+	29	6836	c.6712G>T	c.(6712-6714)GCT>TCT	p.A2238S	ANKHD1_uc003lfr.2_Missense_Mutation_p.A2238S|ANKHD1-EIF4EBP3_uc011czh.1_Missense_Mutation_p.A977S|ANKHD1_uc003lfw.2_Missense_Mutation_p.A876S|ANKHD1_uc010jfl.2_Missense_Mutation_p.A673S|ANKHD1-EIF4EBP3_uc003lfx.1_Missense_Mutation_p.A375S	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	2238						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCACGAGTTGCTACAGATGC	0.507		NA											8	101					1.13e-05	1.24e-05	1	0
NDST1	3340	broad.mit.edu	37	5	149900959	149900959	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr5:149900959C>T	uc003lsk.3	+	2	645	c.143C>T	c.(142-144)TCG>TTG	p.S48L	NDST1_uc011dcj.1_Missense_Mutation_p.S48L|NDST1_uc003lsl.2_Missense_Mutation_p.S48L	NM_001543	NP_001534	P52848	NDST1_HUMAN	N-deacetylase/N-sulfotransferase (heparan	48	Heparan sulfate N-deacetylase 1.|Lumenal (Potential).				heparan sulfate proteoglycan biosynthetic process|inflammatory response	Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			breast(1)|skin(1)	2		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CTGGAGCCCTCGGCGGATGCC	0.652		NA											7	75					0	0	0	0
BAT2	7916	broad.mit.edu	37	6	31598918	31598918	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr6:31598918G>A	uc003nvb.3	+	16	2717	c.2468G>A	c.(2467-2469)AGC>AAC	p.S823N	BAT2_uc011dnv.1_Intron|BAT2_uc003nvc.3_Missense_Mutation_p.S823N	NM_080686	NP_542417	P48634	PRC2A_HUMAN	HLA-B associated transcript-2	823	4 X 57 AA type A repeats.					cytoplasm|nucleus	protein binding				0						CTCTTCAGGAGCGAGACTCCT	0.488		NA											9	91					0	0	0	0
BRPF3	27154	broad.mit.edu	37	6	36175192	36175192	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr6:36175192C>T	uc003olv.3	+	4	1932	c.1708C>T	c.(1708-1710)CGG>TGG	p.R570W	BRPF3_uc010jwb.2_Missense_Mutation_p.R570W|BRPF3_uc011dtj.1_RNA|BRPF3_uc010jwc.2_RNA|BRPF3_uc011dtk.1_Missense_Mutation_p.R570W	NM_015695	NP_056510	Q9ULD4	BRPF3_HUMAN	bromodomain and PHD finger containing, 3	570					histone H3 acetylation|platelet activation|platelet degranulation	cytosol|extracellular region|MOZ/MORF histone acetyltransferase complex	protein binding|zinc ion binding			ovary(1)|skin(1)	2						TGAGCTGATTCGGAAGAGAGA	0.547		NA											4	29					0	0	0	0
COL19A1	1310	broad.mit.edu	37	6	70637839	70637839	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr6:70637839T>C	uc003pfc.1	+	5	422	c.305T>C	c.(304-306)GTA>GCA	p.V102A	COL19A1_uc010kam.1_5'UTR	NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	102	TSP N-terminal.				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						GAGTACTCAGTAGCTGCCATG	0.418		NA											8	85					0	0	0	0
EPB41L2	2037	broad.mit.edu	37	6	131191239	131191239	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr6:131191239C>G	uc003qch.2	-	15	2253	c.2071G>C	c.(2071-2073)GAG>CAG	p.E691Q	EPB41L2_uc003qce.1_Missense_Mutation_p.E69Q|EPB41L2_uc003qcf.1_Intron|EPB41L2_uc003qcg.1_Intron|EPB41L2_uc011eby.1_Intron|EPB41L2_uc003qci.2_Missense_Mutation_p.E621Q|EPB41L2_uc010kfk.2_Intron|EPB41L2_uc010kfl.1_Missense_Mutation_p.E621Q|EPB41L2_uc003qcd.1_5'Flank|EPB41L2_uc003qcj.1_Missense_Mutation_p.E88Q	NM_001431	NP_001422	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2	691					cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			central_nervous_system(1)|skin(1)	2	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)		TTCTTCTCCTCCACTATATTC	0.393		NA											6	45					0	0	0	0
TAGAP	117289	broad.mit.edu	37	6	159457885	159457885	+	Silent	SNP	G	G	A			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr6:159457885G>A	uc003qrz.2	-	10	1502	c.1170C>T	c.(1168-1170)AGC>AGT	p.S390S	TAGAP_uc011eft.1_Silent_p.S327S|TAGAP_uc003qsa.2_Silent_p.S212S	NM_054114	NP_473455	Q8N103	TAGAP_HUMAN	T-cell activation Rho GTPase-activating protein	390					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(1)	1		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-16)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		TTGTCACCCGGCTCTCGAGGC	0.582		NA											4	43					0	0	0	0
SDK1	221935	broad.mit.edu	37	7	3998591	3998591	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr7:3998591G>C	uc003smx.2	+	8	1318	c.1179G>C	c.(1177-1179)GAG>GAC	p.E393D		NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	393	Ig-like C2-type 4.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		CTGAGCCCGAGAGTCGGATTT	0.458		NA											7	101					0	0	0	0
CCDC129	223075	broad.mit.edu	37	7	31683457	31683457	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr7:31683457G>A	uc003tcj.1	+	11	3466	c.2473G>A	c.(2473-2475)GAA>AAA	p.E825K	CCDC129_uc011kad.1_Missense_Mutation_p.E835K|CCDC129_uc003tci.1_Missense_Mutation_p.E676K|CCDC129_uc011kae.1_Missense_Mutation_p.E851K|CCDC129_uc003tck.1_Missense_Mutation_p.E733K	NM_194300	NP_919276	Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	825	Cys-rich.										0						CCCTGGCCCTGAACCCTCAGT	0.567		NA											4	54					0	0	0	0
DDC	1644	broad.mit.edu	37	7	50611665	50611665	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr7:50611665G>A	uc003tpf.3	-	2	205	c.119C>T	c.(118-120)CCG>CTG	p.P40L	DDC_uc010kza.2_Missense_Mutation_p.P40L|DDC_uc003tpg.3_Missense_Mutation_p.P40L	NM_000790	NP_000781	P20711	DDC_HUMAN	dopa decarboxylase (aromatic L-amino acid	40					cellular amino acid metabolic process|hormone biosynthetic process|neurotransmitter secretion	cytosol	aromatic-L-amino-acid decarboxylase activity|protein binding|pyridoxal phosphate binding			ovary(2)	2	Glioma(55;0.08)|all_neural(89;0.245)				Amantadine(DB00915)|Carbidopa(DB00190)|Flupenthixol(DB00875)|L-Tryptophan(DB00150)|Levodopa(DB01235)|Pimozide(DB01100)|Pyridoxal Phosphate(DB00114)|Remoxipride(DB00409)	AGGGATCAGCGGCCGCAGGTA	0.572		NA											12	164					0	0	0	0
ZNF107	51427	broad.mit.edu	37	7	64167909	64167909	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr7:64167909G>C	uc003ttd.2	+	7	2013	c.1227G>C	c.(1225-1227)GAG>GAC	p.E409D	ZNF107_uc003tte.2_Missense_Mutation_p.E409D	NM_016220	NP_057304	Q9UII5	ZN107_HUMAN	zinc finger protein 107	409					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(55;0.00948)|all_lung(88;0.0249)				ATTCTGGAGAGAAACCATACA	0.338		NA											5	30					0	0	0	0
SEMA3E	9723	broad.mit.edu	37	7	82997162	82997162	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr7:82997162T>A	uc003uhy.1	-	17	2534	c.2068A>T	c.(2068-2070)AGG>TGG	p.R690W		NM_012431	NP_036563	O15041	SEM3E_HUMAN	semaphorin 3E precursor	690					axon guidance	extracellular space|membrane	receptor activity			ovary(3)	3		Medulloblastoma(109;0.109)				CTGTGATGCCTGTCCTCCTCA	0.478		NA											6	73					0	0	0	0
ZNF394	84124	broad.mit.edu	37	7	99097343	99097343	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr7:99097343C>T	uc003uqs.2	-	1	535	c.374G>A	c.(373-375)CGA>CAA	p.R125Q	ZNF394_uc003uqt.2_5'UTR|ZNF394_uc003uqu.1_Missense_Mutation_p.R125Q	NM_032164	NP_115540	Q53GI3	ZN394_HUMAN	zinc finger protein 394	125	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					GCAGTGCTCTCGCACCCAGGC	0.652		NA											10	105					0	0	0	0
TAS2R60	338398	broad.mit.edu	37	7	143140947	143140947	+	Silent	SNP	G	G	A			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr7:143140947G>A	uc011ktg.1	+	1	402	c.402G>A	c.(400-402)AAG>AAA	p.K134K	uc003wda.2_Intron	NM_177437	NP_803186	P59551	T2R60_HUMAN	taste receptor, type 2, member 60	134	Helical; Name=4; (Potential).				sensory perception of bitter taste	integral to membrane	G-protein coupled receptor activity			skin(6)	6	Melanoma(164;0.172)					TCTGGCTAAAGCACAAGTTGT	0.478		NA											10	140					0	0	0	0
RAD54B	25788	broad.mit.edu	37	8	95419850	95419850	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr8:95419850C>T	uc003ygk.2	-	5	696	c.598G>A	c.(598-600)GAT>AAT	p.D200N	RAD54B_uc010may.1_Missense_Mutation_p.D7N|RAD54B_uc003ygl.1_RNA	NM_012415	NP_036547	O95073	FSBP_HUMAN	RAD54 homolog B	Error:Variant_position_missing_in_O95073_after_alignment					double-strand break repair via homologous recombination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA translocase activity|protein binding			kidney(2)|lung(1)|skin(1)	4	Breast(36;4.5e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00217)			CTGAAGTCATCTGGAGAGATT	0.418		NA						Direct_reversal_of_damage|Homologous_recombination					4	53					0	0	0	0
SHC3	53358	broad.mit.edu	37	9	91667004	91667004	+	Missense_Mutation	SNP	G	G	A	rs150757692		TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr9:91667004G>A	uc004aqg.2	-	7	1217	c.910C>T	c.(910-912)CGG>TGG	p.R304W		NM_016848	NP_058544	Q92529	SHC3_HUMAN	src homology 2 domain-containing transforming	304	PID.				central nervous system development|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	protein binding|signal transducer activity			lung(3)|skin(1)	4						TGCTTAAACCGGAGCTCAAAG	0.493		NA											4	47					0	0	0	0
ZNF483	158399	broad.mit.edu	37	9	114304152	114304152	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr9:114304152G>C	uc004bff.2	+	6	1161	c.937G>C	c.(937-939)GAA>CAA	p.E313Q	ZNF483_uc004bfg.2_Intron	NM_133464	NP_597721	Q8TF39	ZN483_HUMAN	zinc finger protein 483 isoform a	313					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1						TAATTTCAAAGAAACTTCAGA	0.378		NA											7	123					0	0	0	0
COL27A1	85301	broad.mit.edu	37	9	117014887	117014887	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr9:117014887G>A	uc011lxl.1	+	26	3048	c.3048G>A	c.(3046-3048)ATG>ATA	p.M1016I	COL27A1_uc004bii.2_RNA	NM_032888	NP_116277	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1 precursor	1016	Pro-rich.|Collagen-like 7.|Triple-helical region.				cell adhesion		extracellular matrix structural constituent			ovary(3)|skin(1)	4						ATCGTGGCATGATGGGACCCC	0.612		NA											9	98					0	0	0	0
ZBTB34	403341	broad.mit.edu	37	9	129642755	129642755	+	Silent	SNP	T	T	C			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr9:129642755T>C	uc004bqm.3	+	2	1162	c.1065T>C	c.(1063-1065)AGT>AGC	p.S355S		NM_001099270	NP_001092740	Q8NCN2	ZBT34_HUMAN	zinc finger and BTB domain containing 34	355					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						ATGAGAGCAGTCCCCGGGAGA	0.542		NA											3	30					0	0	0	0
NOTCH1	4851	broad.mit.edu	37	9	139405640	139405640	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr9:139405640C>G	uc004chz.2	-	16	2551	c.2551G>C	c.(2551-2553)GAG>CAG	p.E851Q	NOTCH1_uc004cia.1_Missense_Mutation_p.E81Q	NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	851	Extracellular (Potential).|EGF-like 22.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GAGAAGCTCTCATAGTCCTCG	0.677		NA	T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			5	45					0	0	0	0
NOTCH1	4851	broad.mit.edu	37	9	139409769	139409769	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr9:139409769C>T	uc004chz.2	-	12	1987	c.1987G>A	c.(1987-1989)GAG>AAG	p.E663K	NOTCH1_uc004cia.1_5'Flank	NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	663	Extracellular (Potential).|EGF-like 17; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		CAGGCACACTCGTAGCCATCG	0.637		NA	T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			5	46					0	0	0	0
MCF2	4168	broad.mit.edu	37	X	138699732	138699732	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chrX:138699732C>A	uc004fau.2	-	8	1233	c.939G>T	c.(937-939)GAG>GAT	p.E313D	MCF2_uc004fav.2_Missense_Mutation_p.E313D|MCF2_uc011mwl.1_Missense_Mutation_p.E274D|MCF2_uc010nsh.1_Missense_Mutation_p.E313D|MCF2_uc011mwm.1_Missense_Mutation_p.E274D|MCF2_uc011mwn.1_Missense_Mutation_p.E458D|MCF2_uc004faw.2_Missense_Mutation_p.E373D|MCF2_uc011mwo.1_Missense_Mutation_p.E373D	NM_005369	NP_005360	P10911	MCF2_HUMAN	MCF.2 cell line derived transforming sequence	313	Spectrin.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|membrane|membrane fraction	protein binding|Rho guanyl-nucleotide exchange factor activity			lung(1)|pleura(1)	2	Acute lymphoblastic leukemia(192;0.000127)					TTGCTTTTATCTCATTAACCA	0.393		NA											6	47					0.00198382	0.00211218	1	0
MBD6	114785	broad.mit.edu	37	12	57919453	57919454	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr12:57919453_57919454insT	uc001soj.1	+	6	926_927	c.702_703insT	c.(700-705)AGATCCfs	p.R234fs	MBD6_uc001sok.1_Frame_Shift_Ins_p.R101fs|MBD6_uc001sol.1_5'Flank	NM_052897	NP_443129	Q96DN6	MBD6_HUMAN	methyl-CpG binding domain protein 6	234_235	Pro-rich.					chromosome|nucleus	chromatin binding|DNA binding			central_nervous_system(3)|ovary(1)	4						CTGCCCTCAGATCCAGCCTGGT	0.619		NA											18	154	---	---	---	---	NA	NA	NA	NA
RBM12B	389677	broad.mit.edu	37	8	94746334	94746335	+	Frame_Shift_Ins	INS	-	-	TG			TCGA-CV-7410-01A-21D-2078-08	TCGA-CV-7410-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b89c4f94-b07c-485b-95ba-ffe815616d78	245ef417-846c-48c1-b0ad-f66c8ff88649	g.chr8:94746334_94746335insTG	uc003yfz.2	-	3	2497_2498	c.2304_2305insCA	c.(2302-2307)CCAGAGfs	p.P768fs		NM_203390	NP_976324	Q8IXT5	RB12B_HUMAN	RNA binding motif protein 12B	768_769							nucleotide binding|RNA binding				0	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			CTGAAATGCTCTGGGGGTGGCC	0.673		NA											8	75	---	---	---	---	NA	NA	NA	NA