Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
PRDM16	63976	broad.mit.edu	37	1	3319429	3319429	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:3319429T>G	uc001akf.2	+	6	831	c.751T>G	c.(751-753)TAC>GAC	p.Y251D	PRDM16_uc001akc.2_Missense_Mutation_p.Y251D|PRDM16_uc001akd.2_Missense_Mutation_p.Y251D|PRDM16_uc001ake.2_Missense_Mutation_p.Y251D|PRDM16_uc009vlh.2_5'UTR	NM_022114	NP_071397	Q9HAZ2	PRD16_HUMAN	PR domain containing 16 isoform 1	251	C2H2-type 1; atypical.				brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			lung(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		CCATAAGAAGTACACGTGTGG	0.637		NA	T	EVI1	MDS|AML								49	33					0	0	0	0
CCDC27	148870	broad.mit.edu	37	1	3679735	3679735	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:3679735G>T	uc001akv.2	+	7	1099	c.1018G>T	c.(1018-1020)GAC>TAC	p.D340Y		NM_152492	NP_689705	Q2M243	CCD27_HUMAN	coiled-coil domain containing 27	340	Glu-rich.									skin(1)	1	all_cancers(77;0.0385)|Ovarian(185;0.0634)|Lung NSC(156;0.21)|all_lung(157;0.218)	all_epithelial(116;5.52e-17)|all_lung(118;1.04e-06)|Lung NSC(185;0.000214)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Lung SC(97;0.0367)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.127)		Epithelial(90;1.11e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.35e-22)|GBM - Glioblastoma multiforme(42;3.46e-16)|Colorectal(212;1.17e-05)|COAD - Colon adenocarcinoma(227;5.76e-05)|Kidney(185;0.00036)|BRCA - Breast invasive adenocarcinoma(365;0.000696)|KIRC - Kidney renal clear cell carcinoma(229;0.00558)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.203)		TGGCGAGGAGGACGAGGGCCT	0.617		NA											3	0					0.004672	0.00669548	1	0
KIAA0562	9731	broad.mit.edu	37	1	3754057	3754057	+	Silent	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:3754057G>C	uc001aky.2	-	9	1277	c.918C>G	c.(916-918)CTC>CTG	p.L306L	KIAA0562_uc010nzm.1_RNA|KIAA0562_uc001akz.2_Silent_p.L306L	NM_014704	NP_055519	O60308	CE104_HUMAN	glycine-, glutamate-,	306						centriole	binding				0	all_cancers(77;0.0395)|Ovarian(185;0.0634)|all_lung(157;0.222)|Lung NSC(156;0.227)	all_epithelial(116;3.96e-21)|all_lung(118;2.74e-08)|Lung NSC(185;6.4e-06)|Breast(487;0.00066)|Renal(390;0.00121)|Hepatocellular(190;0.00335)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.031)|Lung SC(97;0.0548)|Medulloblastoma(700;0.212)		Epithelial(90;6.85e-39)|OV - Ovarian serous cystadenocarcinoma(86;1.59e-22)|GBM - Glioblastoma multiforme(42;3.16e-16)|Colorectal(212;2.01e-05)|COAD - Colon adenocarcinoma(227;7.99e-05)|BRCA - Breast invasive adenocarcinoma(365;0.000389)|Kidney(185;0.000513)|STAD - Stomach adenocarcinoma(132;0.00709)|KIRC - Kidney renal clear cell carcinoma(229;0.00714)|Lung(427;0.137)		CGAGGGGCTGGAGGGGCAAAT	0.458		NA											22	27					0	0	0	0
MASP2	10747	broad.mit.edu	37	1	11090242	11090242	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:11090242A>T	uc001aru.2	-	10	1309	c.1288T>A	c.(1288-1290)TGT>AGT	p.C430S		NM_006610	NP_006601	O00187	MASP2_HUMAN	mannan-binding lectin serine protease 2 isoform	430	Sushi 2.				complement activation, classical pathway|complement activation, lectin pathway|proteolysis	extracellular region	calcium ion binding|calcium-dependent protein binding|serine-type endopeptidase activity			ovary(2)|pancreas(1)|skin(1)	4	Ovarian(185;0.249)	Lung NSC(185;1.04e-05)|all_lung(284;1.31e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.071)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.12e-07)|COAD - Colon adenocarcinoma(227;7.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)|STAD - Stomach adenocarcinoma(313;0.192)		CCAGGCTCACAGACTGGGAGT	0.438		NA											45	33					0	0	0	0
LOC649330	649330	broad.mit.edu	37	1	12908094	12908094	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:12908094G>C	uc009vno.2	-	1	144	c.49C>G	c.(49-51)CGT>GGT	p.R17G	HNRNPCL1_uc010obf.1_Missense_Mutation_p.R17G	NM_001146181	NP_001139653	B7ZW38	B7ZW38_HUMAN	heterogeneous nuclear ribonucleoprotein C-like	17							nucleic acid binding|nucleotide binding				0						ATGAACACACGGGAGTTCATG	0.463		NA											33	111					0	0	0	0
TAS1R2	80834	broad.mit.edu	37	1	19168324	19168324	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:19168324T>A	uc001bba.1	-	5	1491	c.1490A>T	c.(1489-1491)AAG>ATG	p.K497M		NM_152232	NP_689418	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2 precursor	497	Extracellular (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	CTGGCACCTCTTGGAACACAT	0.587		NA											25	75					0	0	0	0
UBR4	23352	broad.mit.edu	37	1	19428082	19428082	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:19428082G>T	uc001bbi.2	-	88	12959	c.12955C>A	c.(12955-12957)CGC>AGC	p.R4319S	UBR4_uc010ocv.1_5'Flank|UBR4_uc009vph.2_5'Flank|UBR4_uc010ocw.1_Missense_Mutation_p.R10S|UBR4_uc001bbg.2_Missense_Mutation_p.R30S|UBR4_uc001bbh.2_Missense_Mutation_p.R28S	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	4319					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		AGATTGTAGCGCTTGGCTGTC	0.527		NA											37	79					2.87e-16	5.64e-16	1	0
PINK1	65018	broad.mit.edu	37	1	20977105	20977105	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:20977105T>A	uc001bdm.2	+	8	1761	c.1667T>A	c.(1666-1668)ATG>AAG	p.M556K	PINK1_uc001bdn.2_Missense_Mutation_p.M249K	NM_032409	NP_115785	Q9BXM7	PINK1_HUMAN	PTEN induced putative kinase 1 precursor	556	Cytoplasmic (Potential).				cell death|intracellular protein kinase cascade|mitochondrion degradation|peptidyl-serine phosphorylation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of release of cytochrome c from mitochondria|regulation of protein complex assembly|regulation of protein ubiquitination|response to stress	cytosol|integral to membrane|mitochondrial outer membrane	ATP binding|C3HC4-type RING finger domain binding|calcium-dependent protein kinase activity|magnesium ion binding|protein serine/threonine kinase activity|ubiquitin protein ligase binding			ovary(2)|central_nervous_system(1)	3		all_lung(284;2.72e-05)|Lung NSC(340;2.94e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000147)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(152;1.21e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000146)|Kidney(64;0.000182)|GBM - Glioblastoma multiforme(114;0.000497)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(196;0.00308)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		AAAATGAAGATGCTCTTTCTG	0.542		NA											32	23					0	0	0	0
EPHA8	2046	broad.mit.edu	37	1	22919856	22919856	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:22919856G>A	uc001bfx.1	+	6	1478	c.1353G>A	c.(1351-1353)GCG>GCA	p.A451A		NM_020526	NP_065387	P29322	EPHA8_HUMAN	ephrin receptor EphA8 isoform 1 precursor	451	Extracellular (Potential).|Fibronectin type-III 2.					integral to plasma membrane	ATP binding|ephrin receptor activity			central_nervous_system(5)|breast(3)|lung(2)|large_intestine(1)|stomach(1)|skin(1)	13		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		AAGAGCGGGCGGGGCAGACCA	0.657		NA											3	3					0	0	0	0
EPHA8	2046	broad.mit.edu	37	1	22927255	22927255	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:22927255G>T	uc001bfx.1	+	14	2615	c.2490G>T	c.(2488-2490)GAG>GAT	p.E830D		NM_020526	NP_065387	P29322	EPHA8_HUMAN	ephrin receptor EphA8 isoform 1 precursor	830	Cytoplasmic (Potential).|Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			central_nervous_system(5)|breast(3)|lung(2)|large_intestine(1)|stomach(1)|skin(1)	13		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		TCATGTGGGAGGTGCTGGCCT	0.682		NA											55	45					6.61e-23	1.37e-22	1	0
C1QB	713	broad.mit.edu	37	1	22987522	22987522	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:22987522C>A	uc001bgd.2	+	3	537	c.405C>A	c.(403-405)CGC>CGA	p.R135R		NM_000491	NP_000482	P02746	C1QB_HUMAN	complement component 1, q subcomponent, B chain	135	C1q.				complement activation, classical pathway|innate immune response	collagen|complement component C1 complex				breast(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.06e-27)|Colorectal(126;1.58e-07)|GBM - Glioblastoma multiforme(114;6.72e-06)|COAD - Colon adenocarcinoma(152;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000551)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.198)	Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	TCCCCCTGCGCCGGGACCAGA	0.592		NA											63	50					5.11e-33	1.08e-32	1	0
EPHB2	2048	broad.mit.edu	37	1	23234658	23234658	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:23234658C>A	uc009vqj.1	+	12	2494	c.2349C>A	c.(2347-2349)GCC>GCA	p.A783A	EPHB2_uc001bge.2_Silent_p.A784A|EPHB2_uc001bgf.2_Silent_p.A783A|EPHB2_uc010odu.1_Silent_p.A725A	NM_017449	NP_059145	P29323	EPHB2_HUMAN	ephrin receptor EphB2 isoform 1 precursor	783	Cytoplasmic (Potential).|Protein kinase.				axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			ovary(3)|lung(1)|pancreas(1)	5		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		ACACCAGTGCCCTGGTAAGAT	0.493		NA							Hereditary_Prostate_Cancer				24	22					9.96e-16	1.94e-15	1	0
E2F2	1870	broad.mit.edu	37	1	23857277	23857277	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:23857277T>A	uc001bhe.1	-	1	437	c.9A>T	c.(7-9)CAA>CAT	p.Q3H		NM_004091	NP_004082	Q14209	E2F2_HUMAN	E2F transcription factor 2	3					G1 phase of mitotic cell cycle|transcription initiation from RNA polymerase II promoter	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(2)|skin(2)	4		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.52e-24)|Colorectal(126;6.25e-08)|COAD - Colon adenocarcinoma(152;3.42e-06)|GBM - Glioblastoma multiforme(114;8.98e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00102)|KIRC - Kidney renal clear cell carcinoma(1967;0.00366)|STAD - Stomach adenocarcinoma(196;0.0132)|READ - Rectum adenocarcinoma(331;0.0652)|Lung(427;0.0888)|LUSC - Lung squamous cell carcinoma(448;0.19)		CCCGGGGCCCTTGCAGCATAG	0.721		NA											9	7					0	0	0	0
ARID1A	8289	broad.mit.edu	37	1	27089589	27089589	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:27089589C>T	uc001bmv.1	+	8	2918	c.2545C>T	c.(2545-2547)CCT>TCT	p.P849S	ARID1A_uc001bmt.1_Missense_Mutation_p.P849S|ARID1A_uc001bmu.1_Missense_Mutation_p.P849S|ARID1A_uc001bmw.1_Missense_Mutation_p.P466S	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	849					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		TGGCATCCCACCTTATGGCAC	0.587		NA	Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								17	43					0	0	0	0
CSMD2	114784	broad.mit.edu	37	1	34180246	34180246	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:34180246C>A	uc001bxn.1	-	21	3256	c.3227G>T	c.(3226-3228)CGC>CTC	p.R1076L	CSMD2_uc001bxm.1_Missense_Mutation_p.R1116L	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1076	Sushi 6.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GCACGTGATGCGGGCGGTGCC	0.627		NA											158	105					2.64e-51	5.64e-51	1	0
UTP11L	51118	broad.mit.edu	37	1	38484769	38484769	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:38484769T>A	uc001ccn.3	+	5	472	c.381T>A	c.(379-381)GAT>GAA	p.D127E	UTP11L_uc009vvm.2_Missense_Mutation_p.D58E|UTP11L_uc010oil.1_RNA|UTP11L_uc001cco.3_Missense_Mutation_p.D58E	NM_016037	NP_057121	Q9Y3A2	UTP11_HUMAN	UTP11-like, U3 small nucleolar	127					induction of apoptosis|nerve growth factor receptor signaling pathway|nervous system development|rRNA processing	cytoplasm|extracellular space|nucleolus|small-subunit processome	protein binding				0	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				ATCTGCTGGATTTCCAGGGGA	0.378		NA											34	18					0	0	0	0
MACF1	23499	broad.mit.edu	37	1	39763349	39763349	+	Nonsense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:39763349A>T	uc010ois.1	+	22	2633	c.2428A>T	c.(2428-2430)AAA>TAA	p.K810*	MACF1_uc001cda.1_Nonsense_Mutation_p.K718*|MACF1_uc001cdc.1_5'Flank|MACF1_uc009vvq.1_5'Flank|MACF1_uc001cdb.1_5'Flank	NM_012090	NP_036222	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	810					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AGATTCCATTAAACGAAAATA	0.463		NA											46	26					0	0	0	0
TIE1	7075	broad.mit.edu	37	1	43770797	43770798	+	Missense_Mutation	DNP	CG	CG	AT			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:43770797_43770798CG>AT	uc001ciu.2	+	2	413_414	c.334_335CG>AT	c.(334-336)CGG>ATG	p.R112M	TIE1_uc010okd.1_Missense_Mutation_p.R112M|TIE1_uc010oke.1_Missense_Mutation_p.R67M|TIE1_uc009vwq.2_Missense_Mutation_p.R112M|TIE1_uc010okf.1_Translation_Start_Site|TIE1_uc010okg.1_5'Flank|TIE1_uc010oka.1_Missense_Mutation_p.R112M|TIE1_uc010okb.1_Missense_Mutation_p.R112M|TIE1_uc010okc.1_Missense_Mutation_p.R112M	NM_005424	NP_005415	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and	112	Extracellular (Potential).				mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(3)|stomach(1)|salivary_gland(1)|ovary(1)|skin(1)	7	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TGCTGGGGCGCGGCGCACGCGC	0.703		NA											12	16					0	0	0	0
TAL1	6886	broad.mit.edu	37	1	47689705	47689705	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:47689705G>A	uc001cqx.2	-	3	1089	c.512C>T	c.(511-513)CCT>CTT	p.P171L	TAL1_uc009vyq.2_5'UTR|TAL1_uc001cqy.2_Missense_Mutation_p.P171L|TAL1_uc001cra.1_RNA|TAL1_uc001cqz.1_RNA	NM_003189	NP_003180	P17542	TAL1_HUMAN	T-cell acute lymphocytic leukemia 1	171					basophil differentiation|cell fate commitment|cell proliferation|embryonic hemopoiesis|erythrocyte differentiation|megakaryocyte differentiation|positive regulation of cell division|positive regulation of chromatin assembly or disassembly|positive regulation of erythrocyte differentiation|positive regulation of mitotic cell cycle|positive regulation of protein complex assembly|positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	E-box binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity			lung(1)	1						ATAGGGGGAAGGTCTCCTCTT	0.572		NA	T	TRD@|SIL	lymphoblastic leukemia/biphasic								61	52					0	0	0	0
CYB5RL	606495	broad.mit.edu	37	1	54645006	54645006	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:54645006A>T	uc009vzo.2	-	7	880	c.560T>A	c.(559-561)CTG>CAG	p.L187Q	CYB5RL_uc001cww.2_Missense_Mutation_p.L77Q|CYB5RL_uc001cwx.3_RNA|CYB5RL_uc001cwy.3_Missense_Mutation_p.L39Q	NM_001031672	NP_001026842	Q6IPT4	NB5R5_HUMAN	cytochrome b5 reductase-like	187	FAD (By similarity).						cytochrome-b5 reductase activity				0						GCCCGCAGCCAGCAAGAGGAG	0.542		NA											9	12					0	0	0	0
KANK4	163782	broad.mit.edu	37	1	62728768	62728768	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:62728768C>T	uc001dah.3	-	7	2912	c.2535G>A	c.(2533-2535)GAG>GAA	p.E845E	KANK4_uc001dai.3_Silent_p.E217E|KANK4_uc001daf.3_5'UTR|KANK4_uc001dag.3_Silent_p.E201E	NM_181712	NP_859063	Q5T7N3	KANK4_HUMAN	ankyrin repeat domain 38	845	ANK 1.									ovary(3)|skin(2)|lung(1)	6						TCTGACCTGTCTCCAGCAGCA	0.428		NA											10	10					0	0	0	0
CACHD1	57685	broad.mit.edu	37	1	65138857	65138857	+	Missense_Mutation	SNP	G	G	T	rs148780022		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:65138857G>T	uc001dbo.1	+	18	2479	c.2374G>T	c.(2374-2376)GAC>TAC	p.D792Y	CACHD1_uc001dbp.1_Missense_Mutation_p.D547Y|CACHD1_uc001dbq.1_Missense_Mutation_p.D547Y|CACHD1_uc010opa.1_Missense_Mutation_p.D36Y	NM_020925	NP_065976	Q5VU97	CAHD1_HUMAN	cache domain containing 1	843	Extracellular (Potential).|Cache 2.				calcium ion transport	integral to membrane				ovary(2)	2						CATAATGGAGGACAGGGGTTA	0.453		NA											99	79					2.65e-51	5.67e-51	1	0
LEPR	3953	broad.mit.edu	37	1	66036415	66036415	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:66036415C>A	uc001dci.2	+	4	502	c.300C>A	c.(298-300)TCC>TCA	p.S100S	LEPR_uc001dcg.2_Silent_p.S100S|LEPR_uc001dch.2_Silent_p.S100S|LEPR_uc009waq.2_Silent_p.S100S|LEPR_uc001dcj.2_Silent_p.S100S|LEPR_uc001dck.2_Silent_p.S100S	NM_002303	NP_002294	P48357	LEPR_HUMAN	leptin receptor isoform 1	100	Extracellular (Potential).				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		GAAACTGCTCCTTATGTGCAG	0.333		NA											36	23					1.97e-18	3.94e-18	1	0
WDR78	79819	broad.mit.edu	37	1	67359072	67359072	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:67359072C>A	uc001dcx.2	-	3	426	c.370G>T	c.(370-372)GTT>TTT	p.V124F	WDR78_uc001dcy.2_Missense_Mutation_p.V124F|WDR78_uc001dcz.2_Missense_Mutation_p.V124F|WDR78_uc009wax.2_5'Flank	NM_024763	NP_079039	Q5VTH9	WDR78_HUMAN	WD repeat domain 78 isoform 1	124										ovary(2)	2						CGGGGAGTAACATCAGTTCCA	0.343		NA											26	19					2.49e-11	4.54e-11	1	0
LRRC7	57554	broad.mit.edu	37	1	70493932	70493932	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:70493932G>A	uc001dep.2	+	16	1789	c.1759G>A	c.(1759-1761)GTG>ATG	p.V587M	LRRC7_uc009wbg.2_Intron	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	587						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						TCAAAATTTGGTGGGTAAGCC	0.378		NA											17	54					0	0	0	0
FPGT	8790	broad.mit.edu	37	1	74670412	74670412	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:74670412C>G	uc001dgb.1	+	4	718	c.681C>G	c.(679-681)TTC>TTG	p.F227L	TNNI3K_uc001dgc.1_Intron|TNNI3K_uc001dgd.2_Intron|TNNI3K_uc001dge.1_Intron|FPGT_uc010oqt.1_Intron|FPGT_uc010oqu.1_Intron|FPGT_uc010oqv.1_Intron	NM_003838	NP_003829	O14772	FPGT_HUMAN	fucose-1-phosphate guanyltransferase	227					fucose metabolic process	cytoplasm	fucose-1-phosphate guanylyltransferase activity|GTP binding			skin(1)	1						GCCATCGTTTCCTTCATAAGC	0.403		NA											15	47					0	0	0	0
IFI44L	10964	broad.mit.edu	37	1	79106756	79106756	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:79106756C>A	uc010oro.1	+	7	1278	c.1099C>A	c.(1099-1101)CTT>ATT	p.L367I	IFI44L_uc010orp.1_Missense_Mutation_p.L104I|IFI44L_uc010orq.1_Missense_Mutation_p.L104I	NM_006820	NP_006811	Q53G44	IF44L_HUMAN	interferon-induced protein 44-like	367						cytoplasm					0						CAGTGAGGTTCTTCAAGACAA	0.313		NA											61	34					1.46e-27	3.05e-27	1	0
CCBL2	56267	broad.mit.edu	37	1	89430571	89430571	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:89430571C>A	uc001dmp.2	-	5	771	c.394G>T	c.(394-396)GTA>TTA	p.V132L	CCBL2_uc001dmq.2_Missense_Mutation_p.V98L|CCBL2_uc001dmr.2_5'UTR	NM_001008661	NP_001008661	Q6YP21	KAT3_HUMAN	kynurenine aminotransferase III isoform 1	132					biosynthetic process|kynurenine metabolic process|tryptophan catabolic process		cysteine-S-conjugate beta-lyase activity|kynurenine-glyoxylate transaminase activity|kynurenine-oxoglutarate transaminase activity|pyridoxal phosphate binding			ovary(1)	1		Lung NSC(277;0.123)		all cancers(265;0.0117)|Epithelial(280;0.0341)	L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	TATGCTCCTACTGTCACAAGG	0.333		NA											26	24					7.08e-08	1.2e-07	1	0
DPYD	1806	broad.mit.edu	37	1	97700482	97700482	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:97700482T>A	uc001drv.2	-	19	2505	c.2368A>T	c.(2368-2370)ATT>TTT	p.I790F		NM_000110	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase isoform 1	790					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			ovary(3)|skin(3)|breast(2)	8		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	GTAGCCAAAATGGGAAATCCA	0.463		NA											39	27					0	0	0	0
DPYD	1806	broad.mit.edu	37	1	97771816	97771816	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:97771816C>A	uc001drv.2	-	17	2233	c.2096G>T	c.(2095-2097)AGG>ATG	p.R699M		NM_000110	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase isoform 1	699					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			ovary(3)|skin(3)|breast(2)	8		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	AACAGCTTGCCTAACCCAGCG	0.423		NA											41	157					6.46e-13	1.2e-12	1	0
LPPR5	163404	broad.mit.edu	37	1	99418732	99418732	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:99418732C>A	uc001dsb.2	-	3	737	c.515G>T	c.(514-516)AGT>ATT	p.S172I	LPPR5_uc001dsc.2_Missense_Mutation_p.S172I	NM_001037317	NP_001032394	Q32ZL2	LPPR5_HUMAN	phosphatidic acid phosphatase type 2d isoform 1	172						integral to membrane	hydrolase activity				0						CTCTTCCCCACTGATGAATTG	0.478		NA											32	24					1.89e-17	3.75e-17	1	0
CELSR2	1952	broad.mit.edu	37	1	109803804	109803804	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:109803804G>A	uc001dxa.3	+	3	4160	c.4099G>A	c.(4099-4101)GTG>ATG	p.V1367M		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	1367	Extracellular (Potential).|Laminin G-like 1.				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		CTACTGCCAGGTGACCACGCG	0.632		NA											28	67					0	0	0	0
AMPD2	271	broad.mit.edu	37	1	110170415	110170415	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:110170415C>A	uc009wfh.1	+	10	1674	c.1132C>A	c.(1132-1134)CGG>AGG	p.R378R	AMPD2_uc009wfg.1_RNA|AMPD2_uc001dyb.1_Silent_p.R297R|AMPD2_uc001dyc.1_Silent_p.R378R|AMPD2_uc010ovr.1_Silent_p.R303R|AMPD2_uc010ovs.1_Silent_p.R260R|AMPD2_uc001dyd.1_Silent_p.R259R|AMPD2_uc001dye.1_5'Flank	NM_004037	NP_004028	Q01433	AMPD2_HUMAN	adenosine monophosphate deaminase 2 (isoform L)	378					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			ovary(2)|breast(1)	3		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Lung(183;0.0425)|all cancers(265;0.0884)|Colorectal(144;0.109)|Epithelial(280;0.111)|LUSC - Lung squamous cell carcinoma(189;0.228)		CTGCTACCGCCGGCTGCAGTA	0.557		NA											13	41					1.36e-13	2.58e-13	1	0
GSTM4	2948	broad.mit.edu	37	1	110203833	110203833	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:110203833C>G	uc001dyf.2	+	8	928	c.614C>G	c.(613-615)CCA>CGA	p.P205R	GSTM4_uc001dyg.2_Missense_Mutation_p.P101R|GSTM4_uc009wfj.2_Missense_Mutation_p.P144R|GSTM4_uc001dyh.2_Intron|GSTM2_uc001dyi.2_Intron	NM_000850	NP_000841	Q03013	GSTM4_HUMAN	glutathione S-transferase mu 4 isoform 1	205	GST C-terminal.				xenobiotic metabolic process	endoplasmic reticulum membrane	glutathione transferase activity				0		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		all cancers(265;0.0123)|Colorectal(144;0.0129)|Epithelial(280;0.0147)|Lung(183;0.0422)|COAD - Colon adenocarcinoma(174;0.0471)|LUSC - Lung squamous cell carcinoma(189;0.227)	Glutathione(DB00143)	CGCTTCCTCCCAAAACCTCTG	0.577		NA											16	164					0	0	0	0
PTPN22	26191	broad.mit.edu	37	1	114376998	114376998	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:114376998G>T	uc001eds.2	-	15	2088	c.1958C>A	c.(1957-1959)TCA>TAA	p.S653*	PTPN22_uc009wgq.2_Nonsense_Mutation_p.S598*|PTPN22_uc010owo.1_Nonsense_Mutation_p.S409*|PTPN22_uc001edt.2_Intron|PTPN22_uc009wgr.2_Nonsense_Mutation_p.S653*|PTPN22_uc009wgs.2_Nonsense_Mutation_p.S526*|PTPN22_uc001edu.2_Nonsense_Mutation_p.S653*	NM_015967	NP_057051	Q9Y2R2	PTN22_HUMAN	protein tyrosine phosphatase, non-receptor type	653					negative regulation of T cell activation|negative regulation of T cell receptor signaling pathway|phosphoanandamide dephosphorylation|regulation of B cell receptor signaling pathway|regulation of natural killer cell proliferation|T cell differentiation	internal side of plasma membrane|nucleus|perinuclear region of cytoplasm	kinase binding|protein tyrosine phosphatase activity|SH3 domain binding			kidney(2)|lung(1)|skin(1)	4	Lung SC(450;0.184)	all_cancers(81;1.93e-08)|all_epithelial(167;4.37e-08)|all_lung(203;5.22e-06)|Lung NSC(69;8.94e-06)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CCATTCCAGTGATGTTCCAAT	0.363		NA											26	71					1.18e-14	2.27e-14	1	0
AP4B1	10717	broad.mit.edu	37	1	114442738	114442738	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:114442738C>T	uc001eeb.2	-	5	1045	c.902G>A	c.(901-903)CGC>CAC	p.R301H	uc001edv.1_RNA|AP4B1_uc001eec.2_Missense_Mutation_p.R133H|AP4B1_uc001eed.2_Missense_Mutation_p.R301H|AP4B1_uc010owp.1_Missense_Mutation_p.R202H|AP4B1_uc001eea.1_Missense_Mutation_p.R95H|AP4B1_uc001eee.1_5'Flank|AP4B1_uc010owq.1_Missense_Mutation_p.R208H	NM_006594	NP_006585	Q9Y6B7	AP4B1_HUMAN	adaptor-related protein complex 4, beta 1	301					intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|soluble fraction|trans-Golgi network	protein binding|protein transporter activity			ovary(3)|central_nervous_system(1)	4	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.1e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CAAGATCTGGCGTACATGACA	0.473		NA											41	92					0	0	0	0
SYCP1	6847	broad.mit.edu	37	1	115527424	115527424	+	Nonsense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:115527424A>T	uc001efr.2	+	30	2847	c.2638A>T	c.(2638-2640)AAA>TAA	p.K880*	SYCP1_uc010owt.1_RNA|SYCP1_uc001efq.2_Nonsense_Mutation_p.K880*|SYCP1_uc009wgw.2_Nonsense_Mutation_p.K855*	NM_003176	NP_003167	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	880	Nuclear localization signal (Potential).				cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding			skin(1)	1	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		AGAAAGTAAAAAAAAGAGAAA	0.249		NA											31	66					0	0	0	0
NGF	4803	broad.mit.edu	37	1	115828838	115828838	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:115828838G>A	uc001efu.1	-	3	748	c.579C>T	c.(577-579)GAC>GAT	p.D193D		NM_002506	NP_002497	P01138	NGF_HUMAN	nerve growth factor, beta polypeptide precursor	193					activation of MAPKK activity|activation of phospholipase C activity|anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|negative regulation of cell cycle|nerve growth factor processing|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|Golgi lumen	growth factor activity|nerve growth factor receptor binding			upper_aerodigestive_tract(2)	2	Lung SC(450;0.211)	all_cancers(81;1.07e-06)|all_epithelial(167;4.43e-06)|all_lung(203;2.86e-05)|Lung NSC(69;4.99e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|all cancers(265;0.159)|Epithelial(280;0.179)	Clenbuterol(DB01407)	AGTGCTTTGAGTCAATGCCCC	0.507		NA											23	50					0	0	0	0
IGSF3	3321	broad.mit.edu	37	1	117142746	117142746	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:117142746G>C	uc001egr.1	-	7	2551	c.1846C>G	c.(1846-1848)CGA>GGA	p.R616G	IGSF3_uc001egq.1_Missense_Mutation_p.R636G|IGSF3_uc001egs.1_Missense_Mutation_p.R289G	NM_001007237	NP_001007238	O75054	IGSF3_HUMAN	immunoglobulin superfamily, member 3 isoform 2	616	Ig-like C2-type 5.|Extracellular (Potential).					integral to membrane				ovary(2)	2	Lung SC(450;0.225)	all_cancers(81;1.24e-06)|all_epithelial(167;4.85e-07)|all_lung(203;1.66e-06)|Lung NSC(69;1.11e-05)		Lung(183;0.0142)|Colorectal(144;0.0929)|LUSC - Lung squamous cell carcinoma(189;0.108)|COAD - Colon adenocarcinoma(174;0.139)|all cancers(265;0.159)|Epithelial(280;0.166)		ATGGCAGTTCGGGTTCGGAAG	0.627		NA											10	20					0	0	0	0
HSD3B2	3284	broad.mit.edu	37	1	119958051	119958051	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:119958051G>T	uc001ehs.2	+	1	782	c.9G>T	c.(7-9)TGG>TGT	p.W3C	HSD3B2_uc001eht.2_Missense_Mutation_p.W3C|HSD3B2_uc001ehu.2_Missense_Mutation_p.W3C	NM_000198	NP_000189	P26439	3BHS2_HUMAN	3 beta-hydroxysteroid dehydrogenase 2	3					androgen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			ovary(2)	2	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.015)|LUSC - Lung squamous cell carcinoma(189;0.0836)	NADH(DB00157)|Trilostane(DB01108)	CGATGGGCTGGAGCTGCCTTG	0.552		NA											24	71					7.88e-14	1.49e-13	1	0
PDE4DIP	9659	broad.mit.edu	37	1	145075769	145075769	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:145075769G>C	uc001emh.2	-	1	311	c.94C>G	c.(94-96)CGG>GGG	p.R32G	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elo.2_Missense_Mutation_p.R32G|PDE4DIP_uc001emk.2_Missense_Mutation_p.R32G	NM_022359	NP_071754	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TCCCCGGACCGGTAAGGCGTG	0.716		NA	T	PDGFRB	MPD								11	70					0	0	0	0
LIX1L	128077	broad.mit.edu	37	1	145497393	145497393	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:145497393G>T	uc001enr.2	+	4	672	c.598G>T	c.(598-600)GGC>TGC	p.G200C	NBPF10_uc001emp.3_Intron|LIX1L_uc009wiu.1_5'Flank	NM_153713	NP_714924	Q8IVB5	LIX1L_HUMAN	Lix1 homolog (mouse) like	200										ovary(1)	1	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CTACTACCAGGGCAACAGGGA	0.353		NA											10	41					0.000978159	0.00145136	1	0
GJA5	2702	broad.mit.edu	37	1	147231343	147231343	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:147231343C>A	uc001eps.1	-	2	145	c.4G>T	c.(4-6)GGC>TGC	p.G2C	GJA5_uc001ept.1_Missense_Mutation_p.G2C	NM_181703	NP_859054	P36382	CXA5_HUMAN	connexin 40	2	Cytoplasmic (Potential).				angiogenesis|cell-cell junction assembly|muscle contraction	integral to membrane				ovary(1)	1	all_hematologic(923;0.0276)		LUSC - Lung squamous cell carcinoma(543;0.202)			CTCCAATCGCCCATCTTGGCA	0.493		NA											16	69					2e-07	3.35e-07	1	0
HRNR	388697	broad.mit.edu	37	1	152192079	152192079	+	Missense_Mutation	SNP	C	C	T	rs141565920		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:152192079C>T	uc001ezt.1	-	3	2102	c.2026G>A	c.(2026-2028)GGC>AGC	p.G676S		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	676	6				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCATGTTGGCCGTAGCTGGAA	0.587		NA											90	178					0	0	0	0
CRNN	49860	broad.mit.edu	37	1	152382869	152382869	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:152382869G>T	uc001ezx.2	-	3	763	c.689C>A	c.(688-690)TCT>TAT	p.S230Y		NM_016190	NP_057274	Q9UBG3	CRNN_HUMAN	cornulin	230	Gln-rich.				cell-cell adhesion|response to heat	cytoplasm|membrane	calcium ion binding			ovary(2)|skin(1)	3	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGAGTTCCAGATCCAGTCAC	0.577		NA											98	211					4.71e-34	9.98e-34	1	0
SPRR1B	6699	broad.mit.edu	37	1	153004977	153004977	+	Silent	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:153004977A>G	uc001fba.2	+	2	220	c.156A>G	c.(154-156)AAA>AAG	p.K52K	SPRR1B_uc009wnx.1_RNA	NM_003125	NP_003116	P22528	SPR1B_HUMAN	small proline-rich protein 1B	52	6 X 8 AA approximate tandem repeats.|3.				keratinization|peptide cross-linking	cornified envelope|cytoplasm	protein binding, bridging|structural molecule activity			ovary(1)	1	Lung NSC(65;1.49e-28)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			GCCACCCCAAAGTGCCCGAGC	0.627		NA											13	122					0	0	0	0
NES	10763	broad.mit.edu	37	1	156642721	156642721	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:156642721C>A	uc001fpq.2	-	4	1392	c.1259G>T	c.(1258-1260)GGG>GTG	p.G420V		NM_006617	NP_006608	P48681	NEST_HUMAN	nestin	420	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			ovary(6)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CTGTTTCCTCCCACCCTGTGT	0.657		NA											24	67					4.48e-21	9.13e-21	1	0
OR6K6	128371	broad.mit.edu	37	1	158724824	158724824	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:158724824G>T	uc001fsw.1	+	1	219	c.219G>T	c.(217-219)ATG>ATT	p.M73I		NM_001005184	NP_001005184	Q8NGW6	OR6K6_HUMAN	olfactory receptor, family 6, subfamily K,	73	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_hematologic(112;0.0378)					ACCTAATAATGTTCATTGTCA	0.468		NA											32	125					1.46e-13	2.75e-13	1	0
CCDC19	25790	broad.mit.edu	37	1	159850454	159850454	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:159850454G>A	uc001fui.2	-	8	952	c.934C>T	c.(934-936)CAA>TAA	p.Q312*	CCDC19_uc009wtb.2_RNA|CCDC19_uc001fuj.2_RNA|CCDC19_uc001fuk.2_Nonsense_Mutation_p.Q227*|CCDC19_uc001ful.2_Nonsense_Mutation_p.Q227*|CCDC19_uc009wtc.1_Nonsense_Mutation_p.Q298*	NM_012337	NP_036469	Q9UL16	CCD19_HUMAN	nasopharyngeal epithelium specific protein 1	312	Potential.					mitochondrion|soluble fraction				ovary(1)	1	all_hematologic(112;0.0597)		BRCA - Breast invasive adenocarcinoma(70;0.151)			ATCTCAGCTTGCATCTTCAGT	0.468		NA											16	65					0	0	0	0
DDR2	4921	broad.mit.edu	37	1	162724444	162724444	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:162724444G>A	uc001gcf.2	+	6	681	c.216G>A	c.(214-216)TGG>TGA	p.W72*	DDR2_uc001gcg.2_Nonsense_Mutation_p.W72*	NM_001014796	NP_001014796	Q16832	DDR2_HUMAN	discoidin domain receptor family, member 2	72	Extracellular (Potential).|F5/8 type C.				cell adhesion	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(2)|central_nervous_system(2)|ovary(1)|kidney(1)	6	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.113)			ATGGAGCCTGGTGCCCTGAGA	0.557		NA											38	74					0	0	0	0
RXRG	6258	broad.mit.edu	37	1	165377463	165377464	+	Splice_Site	DNP	CC	CC	AA			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:165377463_165377464CC>AA	uc001gda.2	-	8	1438	c.1138_splice	c.e8+1	p.D380_splice		NM_006917	NP_008848	P48443	RXRG_HUMAN	retinoid X receptor, gamma isoform a						regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding				0	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tretinoin(DB00755)	AGGGCGGTTACCTGGGTTAAAG	0.515		NA											34	66					0	0	0	0
DUSP27	92235	broad.mit.edu	37	1	167097589	167097589	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:167097589C>T	uc001geb.1	+	5	3221	c.3221C>T	c.(3220-3222)TCA>TTA	p.S1074L		NM_001080426	NP_001073895	Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27	1074					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			ovary(3)	3						GTGGAAGAGTCATCCAAGTCA	0.522		NA											10	14					0	0	0	0
SELL	6402	broad.mit.edu	37	1	169673747	169673747	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:169673747G>T	uc001ggk.2	-	5	926	c.728C>A	c.(727-729)CCA>CAA	p.P243Q	C1orf112_uc001ggj.2_Intron|SELL_uc010pls.1_Missense_Mutation_p.P196Q|SELL_uc001ggl.1_Missense_Mutation_p.P256Q	NM_000655	NP_000646	P14151	LYAM1_HUMAN	selectin L precursor	243	Extracellular (Potential).|Sushi 1.				blood coagulation|cell adhesion|leukocyte migration|regulation of immune response	integral to plasma membrane	glycosphingolipid binding|heparin binding|protease binding|sugar binding				0	all_hematologic(923;0.208)					GTTTCCAAATGGTCCACAGGT	0.463		NA											3	3					0.004672	0.00669548	1	0
KIFAP3	22920	broad.mit.edu	37	1	169941740	169941740	+	Splice_Site	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:169941740C>G	uc001ggv.2	-	17	2169	c.1898_splice	c.e17-1	p.Q633_splice	KIFAP3_uc010plx.1_Splice_Site_p.Q335_splice	NM_014970	NP_055785	Q92845	KIFA3_HUMAN	kinesin-associated protein 3						blood coagulation|plus-end-directed vesicle transport along microtubule|protein complex assembly|signal transduction	centrosome|condensed nuclear chromosome|cytosol|endoplasmic reticulum|kinesin II complex|spindle microtubule	kinesin binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GCTGGAGCCTCTGAATAAAAA	0.279		NA											7	18					0	0	0	0
C1orf129	80133	broad.mit.edu	37	1	170961417	170961417	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:170961417G>A	uc001ghg.2	+	12	1271	c.1141G>A	c.(1141-1143)GTA>ATA	p.V381I	C1orf129_uc009wvy.2_Missense_Mutation_p.V188I|C1orf129_uc010plz.1_Missense_Mutation_p.V381I	NM_025063	NP_079339	Q5TGP6	CA129_HUMAN	hypothetical protein LOC80133 isoform 2	381							binding			pancreas(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GGAGGACACCGTAACGGAAGG	0.473		NA											17	75					0	0	0	0
TNFSF18	8995	broad.mit.edu	37	1	173010716	173010716	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:173010716C>T	uc001giu.2	-	3	392	c.391G>A	c.(391-393)GAT>AAT	p.D131N		NM_005092	NP_005083	Q9UNG2	TNF18_HUMAN	tumor necrosis factor (ligand) superfamily,	131	Extracellular (Potential).				anti-apoptosis|cell-cell signaling|immune response|signal transduction	extracellular space|integral to membrane	cytokine activity|tumor necrosis factor receptor binding			central_nervous_system(1)	1						GGAGCTACATCATTGTAGTTT	0.383		NA											40	92					0	0	0	0
TNN	63923	broad.mit.edu	37	1	175049390	175049390	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:175049390C>A	uc001gkl.1	+	4	989	c.876C>A	c.(874-876)CTC>CTA	p.L292L	TNN_uc010pmx.1_Silent_p.L292L	NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	292	Fibronectin type-III 1.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		ATCACTACCTCCTCAGCTACT	0.592		NA											18	37					5.39e-06	8.68e-06	1	0
TNN	63923	broad.mit.edu	37	1	175054604	175054604	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:175054604A>G	uc001gkl.1	+	6	1411	c.1298A>G	c.(1297-1299)AAG>AGG	p.K433R	TNN_uc010pmx.1_Missense_Mutation_p.K433R	NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	433	Fibronectin type-III 2.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		CTGGAGGGCAAGCCGATCCTC	0.532		NA											6	16					0	0	0	0
TNN	63923	broad.mit.edu	37	1	175067479	175067479	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:175067479C>G	uc001gkl.1	+	9	1980	c.1867C>G	c.(1867-1869)CCC>GCC	p.P623A	TNN_uc010pmx.1_Missense_Mutation_p.P534A	NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	623	Fibronectin type-III 5.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		TATTGACAGCCCCAAAAACCT	0.507		NA											40	122					0	0	0	0
ABL2	27	broad.mit.edu	37	1	179077050	179077050	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:179077050C>A	uc001gmj.3	-	12	3639	c.3352G>T	c.(3352-3354)GAC>TAC	p.D1118Y	ABL2_uc010pnf.1_Missense_Mutation_p.D1015Y|ABL2_uc010png.1_Missense_Mutation_p.D994Y|ABL2_uc010pnh.1_Missense_Mutation_p.D1097Y|ABL2_uc001gmg.3_Missense_Mutation_p.D1000Y|ABL2_uc001gmi.3_Missense_Mutation_p.D1103Y|ABL2_uc001gmh.3_Missense_Mutation_p.D1082Y|ABL2_uc010pne.1_Missense_Mutation_p.D979Y	NM_007314	NP_009298	P42684	ABL2_HUMAN	arg tyrosine kinase isoform b	1118	F-actin-binding (By similarity).				axon guidance|cell adhesion|peptidyl-tyrosine phosphorylation|positive regulation of oxidoreductase activity|signal transduction	cytoskeleton|cytosol	ATP binding|magnesium ion binding|manganese ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(8)|breast(3)|ovary(2)|central_nervous_system(1)	14					Adenosine triphosphate(DB00171)|Dasatinib(DB01254)	GAGCAGTAGTCAAGCAGCTGG	0.552		NA	T	ETV6	AML								15	45					7.93e-07	1.31e-06	1	0
TDRD5	163589	broad.mit.edu	37	1	179632540	179632540	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:179632540C>T	uc001gnf.1	+	15	2651	c.2401C>T	c.(2401-2403)CTT>TTT	p.L801F	TDRD5_uc010pnp.1_Missense_Mutation_p.L855F|TDRD5_uc001gnh.1_Missense_Mutation_p.L356F	NM_173533	NP_775804	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	801					DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			ovary(2)|skin(2)|central_nervous_system(1)	5						GCCTTCAGGCCTTGTAAATGG	0.398		NA											16	45					0	0	0	0
CEP350	9857	broad.mit.edu	37	1	180061771	180061771	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:180061771G>C	uc001gnt.2	+	34	6914	c.6531G>C	c.(6529-6531)GAG>GAC	p.E2177D	CEP350_uc009wxl.2_Missense_Mutation_p.E2176D|CEP350_uc001gnv.2_Missense_Mutation_p.E312D|CEP350_uc001gnw.1_5'UTR|CEP350_uc001gnx.1_5'UTR	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	2177						centrosome|nucleus|spindle				ovary(4)	4						CTGGTTCTGAGAGATCAGTAT	0.348		NA											8	16					0	0	0	0
CACNA1E	777	broad.mit.edu	37	1	181705563	181705563	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:181705563A>T	uc001gow.2	+	22	3580	c.3415A>T	c.(3415-3417)ACC>TCC	p.T1139S	CACNA1E_uc009wxs.2_Missense_Mutation_p.T1027S|CACNA1E_uc001gox.1_Missense_Mutation_p.T365S|CACNA1E_uc009wxt.2_Missense_Mutation_p.T365S	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	1139	Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						CTTCAGCACCACCAACCCGTA	0.463		NA											5	13					0	0	0	0
CACNA1E	777	broad.mit.edu	37	1	181754552	181754552	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:181754552C>G	uc001gow.2	+	42	5842	c.5677C>G	c.(5677-5679)CAG>GAG	p.Q1893E	CACNA1E_uc009wxs.2_Missense_Mutation_p.Q1781E|CACNA1E_uc009wxt.2_Missense_Mutation_p.Q1119E	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	1893	Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						GCTGGAGGAACAGGTGAAAGT	0.537		NA											6	19					0	0	0	0
CACNA1E	777	broad.mit.edu	37	1	181759621	181759621	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:181759621C>T	uc001gow.2	+	44	5992	c.5827C>T	c.(5827-5829)CCC>TCC	p.P1943S	CACNA1E_uc009wxs.2_Missense_Mutation_p.P1831S|CACNA1E_uc009wxt.2_Missense_Mutation_p.P1169S	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	1943	Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						TCCACTCTCTCCCCAGGATAT	0.498		NA											9	35					0	0	0	0
GLUL	2752	broad.mit.edu	37	1	182354693	182354693	+	Splice_Site	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:182354693T>C	uc001gpa.1	-	6	816	c.604_splice	c.e6-1	p.W202_splice	GLUL_uc010pnt.1_5'UTR|GLUL_uc001gpb.1_Splice_Site_p.W202_splice|GLUL_uc001gpc.1_Splice_Site_p.W202_splice|GLUL_uc001gpd.1_Splice_Site_p.W202_splice	NM_001033056	NP_001028228	P15104	GLNA_HUMAN	glutamine synthetase						cell proliferation|glutamine biosynthetic process|neurotransmitter uptake	cytosol|Golgi apparatus|mitochondrion	ATP binding|glutamate decarboxylase activity|glutamate-ammonia ligase activity|identical protein binding				0					Asparaginase(DB00023)|L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)|L-Methionine(DB00134)	AAATTCCCACTAGAAACGAGA	0.463		NA											19	51					0	0	0	0
C1orf25	81627	broad.mit.edu	37	1	185114616	185114616	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:185114616T>A	uc001grf.3	-	5	882	c.610A>T	c.(610-612)AGG>TGG	p.R204W	C1orf25_uc010pon.1_Missense_Mutation_p.R48W	NM_030934	NP_112196	Q7Z2T5	TRM1L_HUMAN	N2,N2-dimethylguanosine tRNA	204	C2H2-type.					intracellular	RNA binding|tRNA (guanine-N2-)-methyltransferase activity|zinc ion binding				0						ATGTGGCGCCTAACATGTCCT	0.343		NA											20	61					0	0	0	0
FAM5C	339479	broad.mit.edu	37	1	190067933	190067933	+	Nonsense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:190067933T>A	uc001gse.1	-	8	1748	c.1516A>T	c.(1516-1518)AGA>TGA	p.R506*	FAM5C_uc010pot.1_Nonsense_Mutation_p.R404*	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	506						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					TCTATTCGTCTGTCCGTTTTC	0.488		NA											53	127					0	0	0	0
PTPRC	5788	broad.mit.edu	37	1	198721748	198721748	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:198721748A>T	uc001gur.1	+	31	3530	c.3350A>T	c.(3349-3351)CAG>CTG	p.Q1117L	PTPRC_uc001gus.1_Missense_Mutation_p.Q1069L|PTPRC_uc001gut.1_Missense_Mutation_p.Q956L	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	1117	Tyrosine-protein phosphatase 2.|Cytoplasmic (Potential).				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						ACTGTGTACCAGTACCAATAT	0.378		NA											10	39					0	0	0	0
CAMSAP1L1	23271	broad.mit.edu	37	1	200826433	200826433	+	Splice_Site	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:200826433G>C	uc001gvl.2	+	17	4316	c.4046_splice	c.e17-1	p.G1349_splice	CAMSAP1L1_uc001gvk.2_Splice_Site_p.G1338_splice|CAMSAP1L1_uc001gvm.2_Splice_Site_p.G1322_splice	NM_203459	NP_982284	Q08AD1	CAMP2_HUMAN	calmodulin regulated spectrin-associated protein							cytoplasm|microtubule	protein binding			ovary(2)|large_intestine(1)|pancreas(1)	4						CCCTACCATAGGACCAAAGCT	0.323		NA											10	25					0	0	0	0
KIF21B	23046	broad.mit.edu	37	1	200948800	200948800	+	Silent	SNP	G	G	T	rs144601295		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:200948800G>T	uc001gvs.1	-	30	4340	c.4023C>A	c.(4021-4023)ATC>ATA	p.I1341I	KIF21B_uc001gvr.1_Silent_p.I1328I|KIF21B_uc009wzl.1_Silent_p.I1341I|KIF21B_uc010ppn.1_Silent_p.I1328I	NM_017596	NP_060066	O75037	KI21B_HUMAN	kinesin family member 21B	1341	WD 1.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(3)	6						TTAGAGCTGCGATCTCCTGTC	0.587		NA									OREG0014066	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	73	166					4.5e-31	9.47e-31	1	0
CHIT1	1118	broad.mit.edu	37	1	203192687	203192687	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:203192687C>A	uc001gzn.2	-	5	512	c.416G>T	c.(415-417)TGG>TTG	p.W139L	FMOD_uc010pqi.1_Intron|CHIT1_uc001gzm.1_RNA|CHIT1_uc009xal.1_5'Flank|CHIT1_uc009xam.1_RNA|CHIT1_uc009xan.1_RNA|CHIT1_uc001gzo.2_Missense_Mutation_p.W130L	NM_003465	NP_003456	Q13231	CHIT1_HUMAN	chitotriosidase precursor	139					chitin catabolic process|immune response|response to bacterium	extracellular space|lysosome	cation binding|chitin binding|endochitinase activity				0						TGGGTACTCCCAGTCAAGGTC	0.582		NA											42	83					9.86e-13	1.83e-12	1	0
FCAMR	83953	broad.mit.edu	37	1	207131928	207131928	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:207131928A>T	uc001hfa.3	-	8	2167	c.1667T>A	c.(1666-1668)ATG>AAG	p.M556K	FCAMR_uc001hfb.2_3'UTR|FCAMR_uc009xca.1_3'UTR|FCAMR_uc001hfc.2_Missense_Mutation_p.M531K	NM_001122980	NP_001116452	Q8WWV6	FCAMR_HUMAN	Fc receptor, IgA, IgM, high affinity isoform 2	511	Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(1)	1						ATCCTGGAGCATCTTTCTTTC	0.537		NA											28	62					0	0	0	0
CR1	1378	broad.mit.edu	37	1	207790123	207790123	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:207790123C>G	uc001hfy.2	+	33	5655	c.5515C>G	c.(5515-5517)CGC>GGC	p.R1839G	CR1_uc001hfx.2_Missense_Mutation_p.R2289G	NM_000573	NP_000564	P17927	CR1_HUMAN	complement receptor 1 isoform F precursor	1839	Sushi 28.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			ovary(3)	3						CCCTGCCCCTCGCTGTGAACT	0.507		NA											37	114					0	0	0	0
USH2A	7399	broad.mit.edu	37	1	215847664	215847664	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:215847664G>T	uc001hku.1	-	63	13976	c.13589C>A	c.(13588-13590)TCA>TAA	p.S4530*		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	4530	Fibronectin type-III 31.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TGAGGGTGCTGAGGGGCTGGT	0.512		NA								HNSCC(13;0.011)			43	81					7.05e-23	1.46e-22	1	0
WDR26	80232	broad.mit.edu	37	1	224585902	224585902	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:224585902G>C	uc001hop.3	-	12	1596	c.1230C>G	c.(1228-1230)GAC>GAG	p.D410E	WDR26_uc001hoq.3_Missense_Mutation_p.D394E|WDR26_uc010pvh.1_Missense_Mutation_p.D117E	NM_025160	NP_079436	Q9H7D7	WDR26_HUMAN	WD repeat domain 26 isoform a	557	WD 4.					cytoplasm|nucleus					0				GBM - Glioblastoma multiforme(131;0.0104)		CTAAAACTCTGTCTTGCAAGT	0.358		NA											10	18					0	0	0	0
OBSCN	84033	broad.mit.edu	37	1	228481186	228481186	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:228481186G>T	uc009xez.1	+	41	11044	c.11000G>T	c.(10999-11001)GGA>GTA	p.G3667V	OBSCN_uc001hsn.2_Missense_Mutation_p.G3667V|OBSCN_uc001hsq.1_Missense_Mutation_p.G923V	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	3667	Ig-like 37.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				CTCAGAGATGGAGACAGACAC	0.642		NA											25	50					4.88e-14	9.26e-14	1	0
TAF5L	27097	broad.mit.edu	37	1	229730582	229730582	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:229730582C>A	uc001htq.2	-	5	1398	c.1232G>T	c.(1231-1233)TGG>TTG	p.W411L		NM_014409	NP_055224	O75529	TAF5L_HUMAN	PCAF associated factor 65 beta isoform a	411	WD 3.				histone H3 acetylation|transcription from RNA polymerase II promoter	STAGA complex|transcription factor TFTC complex	sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(1)	1	Breast(184;0.193)|Ovarian(103;0.249)	Prostate(94;0.167)				ATCAAATGACCACAGCCTGGC	0.547		NA											21	92					7.42e-09	1.28e-08	1	0
URB2	9816	broad.mit.edu	37	1	229794961	229794961	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:229794961A>G	uc001hts.1	+	10	4628	c.4492A>G	c.(4492-4494)AGA>GGA	p.R1498G	URB2_uc009xfd.1_Missense_Mutation_p.R1498G	NM_014777	NP_055592	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog	1498						nucleolus				central_nervous_system(2)|ovary(1)	3						GCCGGGAATGAGAGACATCTT	0.507		NA											43	140					0	0	0	0
ACTN2	88	broad.mit.edu	37	1	236912520	236912520	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:236912520G>C	uc001hyf.2	+	14	1816	c.1612G>C	c.(1612-1614)GAT>CAT	p.D538H	ACTN2_uc001hyg.2_Missense_Mutation_p.D330H|ACTN2_uc009xgi.1_Missense_Mutation_p.D538H|ACTN2_uc010pxu.1_Missense_Mutation_p.D227H|ACTN2_uc001hyh.2_Missense_Mutation_p.D226H	NM_001103	NP_001094	P35609	ACTN2_HUMAN	actinin, alpha 2	538	Spectrin 3.				focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			ovary(4)|skin(1)	5	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			CGCTATGGAGGATCTGCAAGA	0.443		NA											17	65					0	0	0	0
RYR2	6262	broad.mit.edu	37	1	237608772	237608772	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:237608772C>A	uc001hyl.1	+	14	1362	c.1242C>A	c.(1240-1242)CGC>CGA	p.R414R		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	414	Cytoplasmic (By similarity).		R -> L (in CPVT1).		cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AAGAATCACGCACAGCCCGAG	0.393		NA											25	109					2.22e-12	4.09e-12	1	0
RYR2	6262	broad.mit.edu	37	1	237947191	237947191	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:237947191A>C	uc001hyl.1	+	90	12299	c.12179A>C	c.(12178-12180)CAG>CCG	p.Q4060P	RYR2_uc010pya.1_Missense_Mutation_p.Q475P	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	4060					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CACTACACGCAGTCAGAAACG	0.483		NA											12	14					0	0	0	0
HNRNPU	3192	broad.mit.edu	37	1	245018845	245018845	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:245018845C>G	uc001iaz.1	-	12	2451	c.2233G>C	c.(2233-2235)GGA>CGA	p.G745R	HNRNPU_uc001iaw.1_RNA|HNRNPU_uc001iax.1_RNA|HNRNPU_uc001iay.1_Missense_Mutation_p.G469R|HNRNPU_uc001iba.1_Missense_Mutation_p.G726R	NM_031844	NP_114032	Q00839	HNRPU_HUMAN	heterogeneous nuclear ribonucleoprotein U	745	Gly-rich.|Poly-Gly.				CRD-mediated mRNA stabilization	catalytic step 2 spliceosome|cell surface|CRD-mediated mRNA stability complex|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	ATP binding|DNA binding|protein binding|RNA binding				0	all_cancers(71;6.97e-06)|all_epithelial(71;0.000104)|all_neural(11;0.0269)|Breast(184;0.0545)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0989)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.00868)			CCACCACTTCCTCCACCGCCA	0.507		NA											30	110					0	0	0	0
AHCTF1	25909	broad.mit.edu	37	1	247013403	247013403	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:247013403C>A	uc001ibu.1	-	32	5912	c.5905G>T	c.(5905-5907)GCC>TCC	p.A1969S	AHCTF1_uc001ibv.1_Missense_Mutation_p.A1978S|AHCTF1_uc009xgs.1_Missense_Mutation_p.A830S|AHCTF1_uc001ibw.1_RNA	NM_015446	NP_056261	Q8WYP5	ELYS_HUMAN	transcription factor ELYS	1969	Necessary for nuclear localization (By similarity).				cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			ovary(5)|skin(2)	7	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			CTAGGTATGGCAGACATATCA	0.428		NA											32	126					8.17e-17	1.61e-16	1	0
OR2C3	81472	broad.mit.edu	37	1	247695520	247695520	+	Nonsense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:247695520A>T	uc009xgy.2	-	2	656	c.294T>A	c.(292-294)TGT>TGA	p.C98*	C1orf150_uc009xgw.2_Intron|C1orf150_uc001ida.3_Intron|C1orf150_uc001idb.3_Intron|C1orf150_uc009xgx.2_Intron|LOC148824_uc001idd.2_5'Flank	NM_198074	NP_932340	Q8N628	OR2C3_HUMAN	olfactory receptor, family 2, subfamily C,	98	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0242)	OV - Ovarian serous cystadenocarcinoma(106;0.0241)			ACTGGACCACACACCCTCCAT	0.577		NA											18	51					0	0	0	0
OR2G3	81469	broad.mit.edu	37	1	247769112	247769112	+	Silent	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:247769112T>C	uc010pyz.1	+	1	225	c.225T>C	c.(223-225)ACT>ACC	p.T75T		NM_001001914	NP_001001914	Q8NGZ4	OR2G3_HUMAN	olfactory receptor, family 2, subfamily G,	75	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			GCTTCACTACTAGCCTTGCTC	0.448		NA											178	207					0	0	0	0
OR13G1	441933	broad.mit.edu	37	1	247835616	247835616	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:247835616G>T	uc001idi.1	-	1	728	c.728C>A	c.(727-729)ACA>AAA	p.T243K		NM_001005487	NP_001005487	Q8NGZ3	O13G1_HUMAN	olfactory receptor, family 13, subfamily G,	243	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			GGTCACCACTGTGAGATGAGA	0.448		NA											44	42					1.42e-22	2.92e-22	1	0
OR14A16	284532	broad.mit.edu	37	1	247978277	247978277	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:247978277C>T	uc001idm.1	-	1	755	c.755G>A	c.(754-756)GGA>GAA	p.G252E		NM_001001966	NP_001001966	Q8NHC5	O14AG_HUMAN	olfactory receptor, family 14, subfamily A,	252	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AGCAATGAATCCAGTGGAAAG	0.433		NA											18	22					0	0	0	0
OR2T8	343172	broad.mit.edu	37	1	248084536	248084536	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:248084536T>C	uc010pzc.1	+	1	217	c.217T>C	c.(217-219)TCC>CCC	p.S73P		NM_001005522	NP_001005522	A6NH00	OR2T8_HUMAN	olfactory receptor, family 2, subfamily T,	73	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0211)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GATGCTGGTTTCCACCACTGT	0.572		NA											6	129					0	0	0	0
OR2AK2	391191	broad.mit.edu	37	1	248129117	248129117	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:248129117T>A	uc010pzd.1	+	1	484	c.484T>A	c.(484-486)TGT>AGT	p.C162S	OR2L13_uc001ids.2_Intron	NM_001004491	NP_001004491	Q8NG84	O2AK2_HUMAN	olfactory receptor, family 2, subfamily AK,	162	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			CATGGTTGCATGTGCATGGGC	0.413		NA											111	148					0	0	0	0
OR2M5	127059	broad.mit.edu	37	1	248309365	248309365	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:248309365G>T	uc010pze.1	+	1	916	c.916G>T	c.(916-918)GGA>TGA	p.G306*		NM_001004690	NP_001004690	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M,	306	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|kidney(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			GAAAGTGTTAGGAAAGGGCAA	0.443		NA											38	52					1.57e-24	3.27e-24	1	0
OR2M3	127062	broad.mit.edu	37	1	248366631	248366631	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:248366631G>T	uc010pzg.1	+	1	262	c.262G>T	c.(262-264)GGC>TGC	p.G88C		NM_001004689	NP_001004689	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M,	88	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CTACCTGTCTGGCAGCAAGTC	0.502		NA											135	417					1.41e-78	3.03e-78	1	0
OR2M3	127062	broad.mit.edu	37	1	248366998	248366998	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:248366998C>A	uc010pzg.1	+	1	629	c.629C>A	c.(628-630)CCT>CAT	p.P210H		NM_001004689	NP_001004689	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M,	210	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			ATTGTTTTCCCTGTTGCAATC	0.418		NA											168	236					5.6e-70	1.2e-69	1	0
OR2T12	127064	broad.mit.edu	37	1	248458876	248458876	+	Missense_Mutation	SNP	T	T	A	rs11339452		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:248458876T>A	uc010pzj.1	-	1	5	c.5A>T	c.(4-6)GAG>GTG	p.E2V		NM_001004692	NP_001004692	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T,	2	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			ATTTCTCATCTCCATAATTTC	0.428		NA											45	60					0	0	0	0
OR2T34	127068	broad.mit.edu	37	1	248737333	248737333	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:248737333G>A	uc001iep.1	-	1	726	c.726C>T	c.(724-726)GCC>GCT	p.A242A		NM_001001821	NP_001001821	Q8NGX1	O2T34_HUMAN	olfactory receptor, family 2, subfamily T,	242	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AGGTGGCCAAGGCCTTCCTGC	0.567		NA											112	127					0	0	0	0
OR2T11	127077	broad.mit.edu	37	1	248790227	248790227	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:248790227G>C	uc001ier.1	-	1	203	c.203C>G	c.(202-204)ACC>AGC	p.T68S		NM_001001964	NP_001001964	Q8NH01	O2T11_HUMAN	olfactory receptor, family 2, subfamily T,	68	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			lung(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GATGAAAAGGGTGTCCATGAT	0.483		NA											41	57					0	0	0	0
CUBN	8029	broad.mit.edu	37	10	16946023	16946023	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:16946023G>T	uc001ioo.2	-	51	8056	c.8004C>A	c.(8002-8004)CAC>CAA	p.H2668Q	CUBN_uc009xjq.1_RNA|CUBN_uc009xjr.1_Missense_Mutation_p.H24Q	NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	2668	CUB 19.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TGGTGACAAAGTGAATCCATA	0.378		NA											11	25					2.81e-09	4.9e-09	1	0
CUBN	8029	broad.mit.edu	37	10	17126346	17126346	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:17126346T>A	uc001ioo.2	-	17	2277	c.2225A>T	c.(2224-2226)CAG>CTG	p.Q742L		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	742	CUB 3.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TTGTTCTCCCTGGGGCTGCTT	0.498		NA											21	41					0	0	0	0
CUBN	8029	broad.mit.edu	37	10	17168764	17168764	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:17168764T>A	uc001ioo.2	-	4	435	c.383A>T	c.(382-384)CAG>CTG	p.Q128L		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	128					cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	ACCTACCTGCTGCAAGCCTTG	0.393		NA											20	30					0	0	0	0
CACNB2	783	broad.mit.edu	37	10	18690910	18690910	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:18690910G>T	uc001ipr.2	+	3	331	c.271G>T	c.(271-273)GAC>TAC	p.D91Y	CACNB2_uc009xjz.1_Missense_Mutation_p.D91Y|CACNB2_uc001ips.2_Missense_Mutation_p.D91Y|CACNB2_uc001ipt.2_Missense_Mutation_p.D91Y|CACNB2_uc010qcl.1_RNA|CACNB2_uc001ipu.2_Missense_Mutation_p.D63Y|CACNB2_uc001ipv.2_Missense_Mutation_p.D63Y|CACNB2_uc009xka.1_Missense_Mutation_p.D63Y|CACNB2_uc001ipw.2_Missense_Mutation_p.D36Y|CACNB2_uc001ipx.2_Missense_Mutation_p.D36Y|CACNB2_uc009xkb.1_Missense_Mutation_p.D37Y|CACNB2_uc010qcm.1_Missense_Mutation_p.D37Y|CACNB2_uc001ipz.2_Missense_Mutation_p.D37Y|CACNB2_uc001ipy.2_Missense_Mutation_p.D37Y|CACNB2_uc010qcn.1_Missense_Mutation_p.D43Y|CACNB2_uc010qco.1_Missense_Mutation_p.D43Y|CACNB2_uc001iqa.2_Missense_Mutation_p.D43Y	NM_201596	NP_963890	Q08289	CACB2_HUMAN	calcium channel, voltage-dependent, beta 2	91					axon guidance|neuromuscular junction development	integral to plasma membrane|sarcolemma|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			large_intestine(1)|central_nervous_system(1)|skin(1)	3					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	TCTGGAGGAGGACCGGGAGGC	0.507		NA											11	56					2.81e-09	4.9e-09	1	0
NEBL	10529	broad.mit.edu	37	10	21108419	21108419	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:21108419C>T	uc001iqi.2	-	20	2386	c.1989G>A	c.(1987-1989)AAG>AAA	p.K663K	NEBL_uc001iqj.2_RNA|NEBL_uc001iqk.2_Intron|NEBL_uc001iql.1_RNA	NM_006393	NP_006384	O76041	NEBL_HUMAN	nebulette sarcomeric isoform	663	Nebulin 18.				regulation of actin filament length		actin binding|structural constituent of muscle			ovary(2)	2						CCGGAGTGGCCTTGTAGTTTT	0.438		NA											32	104					0	0	0	0
ENKUR	219670	broad.mit.edu	37	10	25279433	25279433	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:25279433T>C	uc001isg.1	-	4	718	c.553A>G	c.(553-555)ATG>GTG	p.M185V	ENKUR_uc001ish.1_Missense_Mutation_p.M123V	NM_145010	NP_659447	Q8TC29	ENKUR_HUMAN	enkurin	185	IQ.					cilium|flagellum	calmodulin binding|SH3 domain binding				0						AGCCTTTTCATAGCTGCTTTC	0.408		NA											22	43					0	0	0	0
YME1L1	10730	broad.mit.edu	37	10	27403474	27403474	+	Silent	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:27403474T>C	uc001iti.2	-	19	2336	c.2154A>G	c.(2152-2154)GAA>GAG	p.E718E	YME1L1_uc001itj.2_Silent_p.E661E|YME1L1_uc010qdl.1_Silent_p.E628E|YME1L1_uc009xkv.2_RNA	NM_139312	NP_647473	Q96TA2	YMEL1_HUMAN	YME1-like 1 isoform 1	718					protein catabolic process|proteolysis	membrane|mitochondrion	ATP binding|metal ion binding|metalloendopeptidase activity|nucleoside-triphosphatase activity			ovary(1)	1						TTATTTCTTGTTCGATGGCAG	0.328		NA											12	43					0	0	0	0
LYZL2	119180	broad.mit.edu	37	10	30915774	30915774	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:30915774C>G	uc001ivk.2	-	2	222	c.209G>C	c.(208-210)CGT>CCT	p.R70P		NM_183058	NP_898881	Q7Z4W2	LYZL2_HUMAN	lysozyme-like 2	24					cell wall macromolecule catabolic process	extracellular region	lysozyme activity				0		Prostate(175;0.151)				CAGTTTGCAACGAGTGTAGAT	0.522		NA											27	49					0	0	0	0
ZEB1	6935	broad.mit.edu	37	10	31815599	31815599	+	Splice_Site	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:31815599G>T	uc001ivs.3	+	9	2846	c.2783_splice	c.e9-1	p.G928_splice	ZEB1_uc001ivr.3_Splice_Site_p.G710_splice|ZEB1_uc010qee.1_Splice_Site_p.G710_splice|ZEB1_uc010qef.1_Splice_Site_p.G710_splice|ZEB1_uc001ivt.3_Splice_Site_p.G710_splice|ZEB1_uc001ivu.3_Splice_Site_p.G929_splice|ZEB1_uc001ivv.3_Splice_Site_p.G908_splice|ZEB1_uc010qeh.1_Splice_Site_p.G861_splice|ZEB1_uc009xlp.2_Splice_Site_p.G912_splice	NM_030751	NP_110378	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1 isoform b						cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(3)|central_nervous_system(2)	5		Prostate(175;0.0156)				TTATTTTGCAGGTAAAAGACC	0.348		NA											6	19					0.00198382	0.0028924	1	0
PARD3	56288	broad.mit.edu	37	10	34666965	34666965	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:34666965A>T	uc010qej.1	-	10	1469	c.1469T>A	c.(1468-1470)GTG>GAG	p.V490E	PARD3_uc010qek.1_Missense_Mutation_p.V490E|PARD3_uc010qel.1_Missense_Mutation_p.V490E|PARD3_uc010qem.1_Missense_Mutation_p.V490E|PARD3_uc010qen.1_Missense_Mutation_p.V490E|PARD3_uc010qeo.1_Missense_Mutation_p.V490E|PARD3_uc010qep.1_Missense_Mutation_p.V446E|PARD3_uc010qeq.1_Missense_Mutation_p.V446E|PARD3_uc001ixo.1_Missense_Mutation_p.V220E|PARD3_uc001ixp.1_Missense_Mutation_p.V355E|PARD3_uc001ixq.1_Missense_Mutation_p.V490E|PARD3_uc001ixr.1_Missense_Mutation_p.V490E|PARD3_uc001ixt.1_Missense_Mutation_p.V311E|PARD3_uc001ixu.1_Missense_Mutation_p.V446E|PARD3_uc001ixs.1_Missense_Mutation_p.V143E	NM_019619	NP_062565	Q8TEW0	PARD3_HUMAN	partitioning-defective protein 3 homolog	490	PDZ 2.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			ovary(1)	1		Breast(68;0.0707)				AATGTTTTTCACATAGATTGG	0.478		NA											30	86					0	0	0	0
ZNF248	57209	broad.mit.edu	37	10	38121829	38121829	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:38121829C>A	uc001izd.1	-	6	953	c.454G>T	c.(454-456)GGC>TGC	p.G152C	ZNF248_uc009xmc.2_Intron|ZNF248_uc001izb.2_Intron|ZNF248_uc001izc.2_Intron|ZNF248_uc010qeu.1_Missense_Mutation_p.G152C	NM_021045	NP_066383	Q8NDW4	ZN248_HUMAN	zinc finger protein 248	152					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						ATAATTAAGCCCGAAATATTT	0.323		NA											21	39					2.46e-09	4.32e-09	1	0
ZNF25	219749	broad.mit.edu	37	10	38242024	38242024	+	Silent	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:38242024T>A	uc001ize.1	-	6	507	c.402A>T	c.(400-402)ATA>ATT	p.I134I	ZNF25_uc001izf.1_Silent_p.I98I	NM_145011	NP_659448	P17030	ZNF25_HUMAN	zinc finger protein 25	134	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)|central_nervous_system(1)	4		all_neural(218;0.0218)|Breast(68;0.0389)|Ovarian(717;0.0443)|Renal(717;0.157)				GCTGATGTACTATGAGGGCAG	0.398		NA											43	107					0	0	0	0
RET	5979	broad.mit.edu	37	10	43595965	43595965	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:43595965G>T	uc001jal.2	+	2	322	c.132G>T	c.(130-132)CAG>CAT	p.Q44H	RET_uc001jak.1_Missense_Mutation_p.Q44H	NM_020975	NP_066124	P07949	RET_HUMAN	ret proto-oncogene isoform a	44	Extracellular (Potential).				homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity			thyroid(404)|adrenal_gland(20)|lung(9)|large_intestine(5)|breast(4)|ovary(4)|central_nervous_system(3)|urinary_tract(1)|NS(1)	451		Ovarian(717;0.0423)			Sunitinib(DB01268)	ATGTGGACCAGGCAGCCGGCA	0.612		1	T|Mis|N|F	H4|PRKAR1A|NCOA4|PCM1|GOLGA5|TRIM33|KTN1|TRIM27|HOOK3	medullary thyroid| papillary thyroid|pheochromocytoma	medullary thyroid| papillary thyroid|pheochromocytoma	Hirschsprung disease		Multiple_Endocrine_Neoplasia_type_2B|Multiple_Endocrine_Neoplasia_type_2A|Familial_Medullary_Thyroid_Carcinoma				19	41					7.21e-19	1.45e-18	1	0
GDF10	2662	broad.mit.edu	37	10	48438504	48438504	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:48438504G>A	uc001jfb.2	-	1	663	c.207C>T	c.(205-207)CCC>CCT	p.P69P	GDF10_uc009xnp.2_Silent_p.P69P|GDF10_uc009xnq.1_Silent_p.P69P	NM_004962	NP_004953	P55107	BMP3B_HUMAN	growth differentiation factor 10 precursor	69					growth|skeletal system development|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			lung(1)|central_nervous_system(1)	2						CCTGGGCGCTGGGGCCCAACG	0.741		NA											8	14					0	0	0	0
FRMPD2	143162	broad.mit.edu	37	10	49431169	49431169	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:49431169A>T	uc001jgi.2	-	11	1420	c.1313T>A	c.(1312-1314)CTC>CAC	p.L438H	FRMPD2_uc001jgh.2_Missense_Mutation_p.L407H|FRMPD2_uc001jgj.2_Missense_Mutation_p.L416H	NM_001018071	NP_001018081	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2 isoform 3	438	FERM.				tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			large_intestine(1)	1				Kidney(211;0.201)		CACTCACTGGAGCAGCCCATA	0.398		NA											30	59					0	0	0	0
ERCC6	2074	broad.mit.edu	37	10	50667067	50667067	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:50667067C>G	uc001jhs.3	-	21	4430	c.4276G>C	c.(4276-4278)GAC>CAC	p.D1426H	ERCC6_uc009xod.2_Missense_Mutation_p.D586H|ERCC6_uc010qgr.1_Missense_Mutation_p.D796H|ERCC6_uc001jhr.3_Missense_Mutation_p.D794H	NM_000124	NP_000115	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent	1426	Ubiquitin-binding domain (UBD).				base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			lung(5)|breast(5)|ovary(3)|large_intestine(2)|skin(1)	16						ACCAGAAGGTCATCGTGTTCT	0.527		NA						Direct_reversal_of_damage|NER					25	70					0	0	0	0
OGDHL	55753	broad.mit.edu	37	10	50966454	50966454	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:50966454T>A	uc001jie.2	-	2	327	c.185A>T	c.(184-186)AAC>ATC	p.N62I	OGDHL_uc009xog.2_Missense_Mutation_p.N89I|OGDHL_uc010qgt.1_Missense_Mutation_p.N62I|OGDHL_uc010qgu.1_Intron|OGDHL_uc009xoh.2_Intron	NM_018245	NP_060715	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like isoform a	62					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			pancreas(1)	1						ACTCTGGGGGTTTTCCAACCA	0.662		NA											31	92					0	0	0	0
A1CF	29974	broad.mit.edu	37	10	52575947	52575947	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:52575947G>A	uc001jjj.2	-	9	1148	c.960C>T	c.(958-960)GGC>GGT	p.G320G	A1CF_uc010qhn.1_Silent_p.G328G|A1CF_uc001jji.2_Silent_p.G320G|A1CF_uc001jjh.2_Silent_p.G328G|A1CF_uc010qho.1_Silent_p.G328G|A1CF_uc009xov.2_Silent_p.G320G	NM_138932	NP_620310	Q9NQ94	A1CF_HUMAN	apobec-1 complementation factor isoform 2	320					cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			central_nervous_system(1)	1						GCAGCATGGTGCCCCTTCCAC	0.517		NA											12	53					0	0	0	0
PCDH15	65217	broad.mit.edu	37	10	55569197	55569197	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:55569197G>T	uc010qhs.1	-	37	5023	c.4628C>A	c.(4627-4629)ACA>AAA	p.T1543K	PCDH15_uc010qhq.1_Intron|PCDH15_uc010qhr.1_Intron|PCDH15_uc010qht.1_Missense_Mutation_p.T1536K|PCDH15_uc010qhu.1_3'UTR	NM_001142769	NP_001136241	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD2-1 precursor	Error:Variant_position_missing_in_Q96QU1_after_alignment					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				CTTCCATGTTGTGTATGTAGG	0.398		NA								HNSCC(58;0.16)			52	151					1.36e-18	2.74e-18	1	0
PCDH15	65217	broad.mit.edu	37	10	56106245	56106245	+	Splice_Site	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:56106245C>A	uc001jju.1	-	6	870	c.475_splice	c.e6-1	p.L159_splice	PCDH15_uc010qhq.1_Splice_Site_p.L164_splice|PCDH15_uc010qhr.1_Splice_Site_p.L159_splice|PCDH15_uc010qhs.1_Splice_Site_p.L164_splice|PCDH15_uc010qht.1_Splice_Site_p.L159_splice|PCDH15_uc010qhu.1_Splice_Site_p.L159_splice|PCDH15_uc001jjv.1_Splice_Site_p.L137_splice|PCDH15_uc010qhv.1_Splice_Site_p.L159_splice|PCDH15_uc010qhw.1_Splice_Site_p.L159_splice|PCDH15_uc010qhx.1_Splice_Site_p.L159_splice|PCDH15_uc010qhy.1_Splice_Site_p.L164_splice|PCDH15_uc010qhz.1_Splice_Site_p.L159_splice|PCDH15_uc010qia.1_Splice_Site_p.L137_splice|PCDH15_uc010qib.1_Splice_Site_p.L137_splice|PCDH15_uc001jjw.2_Splice_Site_p.L159_splice	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor						equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				CTGGAGTGAGCTGAAAGGAAA	0.338		NA								HNSCC(58;0.16)			34	89					2.27e-22	4.66e-22	1	0
ANK3	288	broad.mit.edu	37	10	62039399	62039399	+	Splice_Site	SNP	T	T	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:62039399T>G	uc001jky.2	-	2	307	c.115_splice	c.e2-1	p.S39_splice	ANK3_uc010qih.1_Splice_Site_p.S22_splice|ANK3_uc001jkz.3_Splice_Site_p.S33_splice|ANK3_uc001jlb.1_Splice_Site	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1						establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						GGCATCAGACTAAAATAAAAA	0.333		NA											25	64					0	0	0	0
MYPN	84665	broad.mit.edu	37	10	69961674	69961674	+	Silent	SNP	C	C	A	rs139820597	byFrequency	TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:69961674C>A	uc001jnm.3	+	19	3767	c.3582C>A	c.(3580-3582)CGC>CGA	p.R1194R	MYPN_uc001jnn.3_Silent_p.R919R|MYPN_uc001jno.3_Silent_p.R1194R|MYPN_uc009xpt.2_Silent_p.R1194R|MYPN_uc010qit.1_Silent_p.R900R|MYPN_uc010qiu.1_RNA	NM_032578	NP_115967	Q86TC9	MYPN_HUMAN	myopalladin	1194	Interaction with ACTN.|Ig-like 5.					nucleus|sarcomere	actin binding			ovary(3)|skin(2)	5						TGGAGTGCCGCGTGATAGGCA	0.547		NA											34	84					1.57e-10	2.83e-10	1	0
CDH23	64072	broad.mit.edu	37	10	73550138	73550138	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:73550138A>G	uc001jrx.3	+	44	6394	c.6017A>G	c.(6016-6018)CAG>CGG	p.Q2006R		NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	2006	Cadherin 19.|Extracellular (Potential).				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11						CTGGGTGCCCAGAGTGGCCTC	0.632		NA											11	36					0	0	0	0
KIAA0913	23053	broad.mit.edu	37	10	75558105	75558105	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:75558105C>A	uc009xrl.2	+	20	4087	c.4055C>A	c.(4054-4056)TCC>TAC	p.S1352Y	KIAA0913_uc001jve.2_Missense_Mutation_p.S1357Y|KIAA0913_uc001jvf.2_Missense_Mutation_p.S1352Y|KIAA0913_uc001jvh.2_RNA|KIAA0913_uc001jvi.2_Missense_Mutation_p.S787Y|KIAA0913_uc010qkr.1_Missense_Mutation_p.S775Y|KIAA0913_uc001jvj.2_Missense_Mutation_p.S775Y|KIAA0913_uc009xrn.1_5'Flank	NM_015037	NP_055852	A7E2V4	K0913_HUMAN	hypothetical protein LOC23053	1352							zinc ion binding			breast(1)	1	Prostate(51;0.0112)					GCAAGAGACTCCAATATGGTG	0.617		NA											20	57					8.01e-06	1.28e-05	1	0
MYST4	23522	broad.mit.edu	37	10	76788996	76788996	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:76788996G>T	uc001jwn.1	+	18	4907	c.4414G>T	c.(4414-4416)GAG>TAG	p.E1472*	MYST4_uc001jwo.1_Nonsense_Mutation_p.E1180*|MYST4_uc001jwp.1_Nonsense_Mutation_p.E1289*	NM_012330	NP_036462	Q8WYB5	MYST4_HUMAN	MYST histone acetyltransferase (monocytic	1472					histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|breast(2)|skin(1)|prostate(1)	16	all_cancers(46;0.0347)|all_epithelial(25;0.00236)|Prostate(51;0.0112)|Ovarian(15;0.0964)					CTCGAACCCAGAGGTCTTAAT	0.512		NA	T	CREBBP	AML								21	66					1.11e-12	2.05e-12	1	0
KCNMA1	3778	broad.mit.edu	37	10	78729807	78729807	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:78729807G>C	uc001jxn.2	-	20	2462	c.2285C>G	c.(2284-2286)TCA>TGA	p.S762*	KCNMA1_uc001jxj.2_Nonsense_Mutation_p.S708*|KCNMA1_uc001jxk.1_Nonsense_Mutation_p.S380*|KCNMA1_uc009xrt.1_Nonsense_Mutation_p.S553*|KCNMA1_uc001jxl.1_Nonsense_Mutation_p.S387*|KCNMA1_uc001jxo.2_Nonsense_Mutation_p.S704*|KCNMA1_uc001jxm.2_Nonsense_Mutation_p.S704*|KCNMA1_uc001jxq.2_Nonsense_Mutation_p.S707*	NM_001161352	NP_001154824	Q12791	KCMA1_HUMAN	large conductance calcium-activated potassium	762	Cytoplasmic (Potential).				cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			pancreas(2)|ovary(1)	3	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	TGATAGTGTTGACGGCTGCTC	0.483		NA											22	84					0	0	0	0
KCNMA1	3778	broad.mit.edu	37	10	78846339	78846339	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:78846339G>T	uc001jxn.2	-	11	1524	c.1347C>A	c.(1345-1347)AAC>AAA	p.N449K	KCNMA1_uc001jxj.2_Missense_Mutation_p.N449K|KCNMA1_uc001jxk.1_Missense_Mutation_p.N64K|KCNMA1_uc009xrt.1_Missense_Mutation_p.N269K|KCNMA1_uc001jxl.1_Missense_Mutation_p.N103K|KCNMA1_uc001jxo.2_Missense_Mutation_p.N449K|KCNMA1_uc001jxm.2_Missense_Mutation_p.N449K|KCNMA1_uc001jxq.2_Missense_Mutation_p.N449K	NM_001161352	NP_001154824	Q12791	KCMA1_HUMAN	large conductance calcium-activated potassium	449	RCK N-terminal.|Cytoplasmic (Potential).			N -> D (in Ref. 12; AAD31173).	cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			pancreas(2)|ovary(1)	3	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	CAAGCTCCAGGTTGGGGGAGA	0.468		NA											16	26					8.6e-14	1.63e-13	1	0
NRG3	10718	broad.mit.edu	37	10	84745231	84745231	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:84745231G>C	uc001kco.2	+	9	1988	c.1961G>C	c.(1960-1962)AGC>ACC	p.S654T	NRG3_uc010qlz.1_Missense_Mutation_p.S653T|NRG3_uc001kcp.2_Missense_Mutation_p.S457T|NRG3_uc001kcq.2_Missense_Mutation_p.S304T|NRG3_uc001kcr.2_Missense_Mutation_p.S328T	NM_001010848	NP_001010848	P56975	NRG3_HUMAN	neuregulin 3 isoform 1	678	Cytoplasmic (Potential).				regulation of cell growth	extracellular region|integral to plasma membrane	growth factor activity|receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			lung(5)|breast(1)	6				GBM - Glioblastoma multiforme(1;2.5e-18)|all cancers(1;2.85e-09)		GAACTGGCCAGCGTAGAAACC	0.473		NA											17	26					0	0	0	0
C10orf99	387695	broad.mit.edu	37	10	85944465	85944465	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:85944465C>A	uc001kcu.2	+	3	243	c.189C>A	c.(187-189)TGC>TGA	p.C63*		NM_207373	NP_997256	Q6UWK7	CJ099_HUMAN	hypothetical protein LOC387695 precursor	63						extracellular region				pancreas(1)	1						GTAAACCATGCAAGCTTGAGC	0.577		NA											24	58					1.77e-15	3.45e-15	1	0
FAS	355	broad.mit.edu	37	10	90762893	90762893	+	Silent	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:90762893T>A	uc001kfr.2	+	2	484	c.138T>A	c.(136-138)ACT>ACA	p.T46T	FAS_uc010qna.1_RNA|FAS_uc001kfs.2_Silent_p.T46T|FAS_uc001kft.2_Silent_p.T46T|FAS_uc010qnb.1_RNA|FAS_uc010qnc.1_RNA|FAS_uc001kfw.2_Silent_p.T46T|FAS_uc010qnd.1_RNA|FAS_uc010qne.1_RNA|FAS_uc009xtp.2_RNA	NM_000043	NP_000034	P25445	TNR6_HUMAN	tumor necrosis factor receptor superfamily,	46	Extracellular (Potential).				activation of caspase activity|activation of pro-apoptotic gene products|anti-apoptosis|cellular response to mechanical stimulus|positive regulation of necrotic cell death	cytosol|extracellular region|integral to membrane|soluble fraction	identical protein binding|kinase binding			upper_aerodigestive_tract(1)|breast(1)	2		Colorectal(252;0.0161)		Colorectal(12;0.000136)|COAD - Colon adenocarcinoma(12;0.000193)		CAGTTGAGACTCAGAACTTGG	0.443		NA							Autoimmune_Lymphoproliferative_syndrome_type_I				27	64					0	0	0	0
TNKS2	80351	broad.mit.edu	37	10	93601155	93601155	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:93601155C>A	uc001khp.2	+	15	2086	c.1789C>A	c.(1789-1791)CAT>AAT	p.H597N		NM_025235	NP_079511	Q9H2K2	TNKS2_HUMAN	tankyrase, TRF1-interacting ankyrin-related	597	ANK 12.				positive regulation of canonical Wnt receptor signaling pathway|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein polyubiquitination|Wnt receptor signaling pathway	Golgi membrane|microsome|nuclear envelope|pericentriolar material|perinuclear region of cytoplasm	NAD+ ADP-ribosyltransferase activity|protein binding			kidney(3)|skin(3)|ovary(1)|lung(1)	8		Colorectal(252;0.162)				TACACCTTTACATGAAGCAGC	0.323		NA											17	57					2.94e-08	5.05e-08	1	0
CYP2C19	1557	broad.mit.edu	37	10	96535277	96535277	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:96535277G>C	uc010qnz.1	+	3	462	c.462G>C	c.(460-462)GAG>GAC	p.E154D	CYP2C19_uc009xus.1_Intron|CYP2C19_uc010qny.1_Missense_Mutation_p.E132D	NM_000769	NP_000760	P33261	CP2CJ_HUMAN	cytochrome P450, family 2, subfamily C,	154					exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding|steroid hydroxylase activity			ovary(4)|central_nervous_system(1)|skin(1)	6		Colorectal(252;0.09)		all cancers(201;6.02e-07)|KIRC - Kidney renal clear cell carcinoma(50;0.0672)|Kidney(138;0.0838)	Adinazolam(DB00546)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Amoxicillin(DB01060)|Arformoterol(DB01274)|Bortezomib(DB00188)|Carisoprodol(DB00395)|Chlorzoxazone(DB00356)|Cilostazol(DB01166)|Citalopram(DB00215)|Clarithromycin(DB01211)|Clobazam(DB00349)|Desipramine(DB01151)|Desloratadine(DB00967)|Diclofenac(DB00586)|Diltiazem(DB00343)|Efavirenz(DB00625)|Esomeprazole(DB00736)|Famotidine(DB00927)|Felbamate(DB00949)|Finasteride(DB01216)|Flunitrazepam(DB01544)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Fosphenytoin(DB01320)|Guanfacine(DB01018)|Imipramine(DB00458)|Indomethacin(DB00328)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Lapatinib(DB01259)|Loratadine(DB00455)|Melatonin(DB01065)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Moclobemide(DB01171)|Modafinil(DB00745)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Nilutamide(DB00665)|Norgestrel(DB00506)|Omeprazole(DB00338)|Oxcarbazepine(DB00776)|Pantoprazole(DB00213)|Pentamidine(DB00738)|Phenobarbital(DB01174)|Phenytoin(DB00252)|Primidone(DB00794)|Progesterone(DB00396)|Proguanil(DB01131)|Promazine(DB00420)|Quinidine(DB00908)|Rabeprazole(DB01129)|Ranitidine(DB00863)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Temazepam(DB00231)|Teniposide(DB00444)|Terfenadine(DB00342)|Thalidomide(DB01041)|Thioridazine(DB00679)|Ticlopidine(DB00208)|Tolbutamide(DB01124)|Topiramate(DB00273)|Tranylcypromine(DB00752)|Troglitazone(DB00197)|Troleandomycin(DB01361)|Voriconazole(DB00582)	GCCTTGTGGAGGAGTTGAGAA	0.517		NA											39	121					0	0	0	0
ABCC2	1244	broad.mit.edu	37	10	101544522	101544522	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:101544522T>A	uc001kqf.2	+	2	330	c.191T>A	c.(190-192)CTC>CAC	p.L64H		NM_000392	NP_000383	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP),	64	Cytoplasmic (By similarity).					apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	ACCACCAAACTCTATCTTGCT	0.473		NA											28	55					0	0	0	0
ELOVL3	83401	broad.mit.edu	37	10	103988898	103988898	+	Silent	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:103988898A>G	uc001kut.2	+	4	865	c.702A>G	c.(700-702)GAA>GAG	p.E234E		NM_152310	NP_689523	Q9HB03	ELOV3_HUMAN	elongation of very long chain fatty acids like	234					fatty acid elongation, monounsaturated fatty acid|fatty acid elongation, polyunsaturated fatty acid|fatty acid elongation, saturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	fatty acid elongase activity|protein binding			ovary(2)	2		Colorectal(252;0.207)		Epithelial(162;4.47e-08)|all cancers(201;7.96e-07)		CCACGATGGAACACTTATTCT	0.498		NA											15	37					0	0	0	0
PDCD4	27250	broad.mit.edu	37	10	112647635	112647635	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:112647635A>T	uc001kzh.2	+	6	1011	c.768A>T	c.(766-768)AGA>AGT	p.R256S	PDCD4_uc001kzg.2_Missense_Mutation_p.R245S|PDCD4_uc010qre.1_Missense_Mutation_p.R242S	NM_014456	NP_055271	Q53EL6	PDCD4_HUMAN	programmed cell death 4 isoform 1	256	MI 1.				apoptosis|cell aging|negative regulation of cell cycle|negative regulation of JUN kinase activity|negative regulation of transcription, DNA-dependent	cytosol|nucleus	protein binding|RNA binding			ovary(1)|breast(1)|skin(1)	3		Breast(234;0.0848)|Lung NSC(174;0.238)		Epithelial(162;0.000526)|all cancers(201;0.00794)|BRCA - Breast invasive adenocarcinoma(275;0.125)		ATACTCCTAGAGCACCACAGG	0.353		NA											14	28					0	0	0	0
DCLRE1A	9937	broad.mit.edu	37	10	115608754	115608754	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:115608754A>G	uc001law.2	-	2	3028	c.2110T>C	c.(2110-2112)TAT>CAT	p.Y704H		NM_014881	NP_055696	Q6PJP8	DCR1A_HUMAN	DNA cross-link repair 1A	704					cell division|mitosis	nucleus	hydrolase activity			skin(2)	2				Epithelial(162;0.0157)|all cancers(201;0.0171)		ATTTTCTTATAGAATGGACAT	0.378		NA						Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					67	136					0	0	0	0
ATRNL1	26033	broad.mit.edu	37	10	117075142	117075142	+	Missense_Mutation	SNP	G	G	A	rs140980345		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:117075142G>A	uc001lcg.2	+	18	3319	c.2933G>A	c.(2932-2934)CGG>CAG	p.R978Q	ATRNL1_uc010qsm.1_Missense_Mutation_p.R153Q|ATRNL1_uc010qsn.1_RNA	NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	978	PSI 5.|Extracellular (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		GGTTCTTCACGGGGACCAATG	0.458		NA											27	67					0	0	0	0
KCNK18	338567	broad.mit.edu	37	10	118957144	118957144	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:118957144G>T	uc010qsr.1	+	1	145	c.145G>T	c.(145-147)GTC>TTC	p.V49F		NM_181840	NP_862823	Q7Z418	KCNKI_HUMAN	potassium channel, subfamily K, member 18	49						integral to membrane|plasma membrane				upper_aerodigestive_tract(1)	1		Colorectal(252;0.19)		all cancers(201;0.0211)		GGACGGCCAGGTCCTGGTGGC	0.572		NA											16	49					3.46e-05	5.44e-05	1	0
HTRA1	5654	broad.mit.edu	37	10	124266322	124266322	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:124266322G>T	uc001lgj.2	+	4	1021	c.893G>T	c.(892-894)AGC>ATC	p.S298I		NM_002775	NP_002766	Q92743	HTRA1_HUMAN	HtrA serine peptidase 1 precursor	298	Serine protease.				proteolysis|regulation of cell growth	extracellular space	insulin-like growth factor binding|serine-type endopeptidase activity				0		all_neural(114;0.0765)|Lung NSC(174;0.133)|all_lung(145;0.163)|Breast(234;0.238)				GGGATCGTGAGCACCACCCAG	0.622		NA											25	75					8.25e-16	1.62e-15	1	0
DMBT1	1755	broad.mit.edu	37	10	124339216	124339216	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:124339216G>A	uc001lgk.1	+	10	908	c.802G>A	c.(802-804)GCC>ACC	p.A268T	DMBT1_uc001lgl.1_Missense_Mutation_p.A268T|DMBT1_uc001lgm.1_Missense_Mutation_p.A268T|DMBT1_uc009xzz.1_Missense_Mutation_p.A268T|DMBT1_uc010qtx.1_Intron|DMBT1_uc009yaa.1_Missense_Mutation_p.A120T	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	268	SRCR 2.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				CACCAATGATGCCAATGTGGT	0.607		NA											139	346					0	0	0	0
C10orf120	399814	broad.mit.edu	37	10	124457725	124457725	+	Missense_Mutation	SNP	C	C	T	rs148798284		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:124457725C>T	uc001lgn.2	-	3	564	c.532G>A	c.(532-534)GGA>AGA	p.G178R		NM_001010912	NP_001010912	Q5SQS8	CJ120_HUMAN	hypothetical protein LOC399814	178										kidney(1)	1		all_neural(114;0.169)|Glioma(114;0.222)				TGATGATTTCCCAGAGCCCGA	0.502		NA											35	85					0	0	0	0
C10orf88	80007	broad.mit.edu	37	10	124708266	124708266	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:124708266T>A	uc001lgw.2	-	4	772	c.547A>T	c.(547-549)AGG>TGG	p.R183W	C10orf88_uc001lgx.2_Missense_Mutation_p.R85W	NM_024942	NP_079218	Q9H8K7	CJ088_HUMAN	hypothetical protein LOC80007	183											0		all_neural(114;0.0765)|Lung NSC(174;0.163)|all_lung(145;0.205)		Colorectal(40;0.0686)|COAD - Colon adenocarcinoma(40;0.0735)		AGGTCTATCCTTGATCCTAGA	0.458		NA											28	33					0	0	0	0
DOCK1	1793	broad.mit.edu	37	10	129224216	129224216	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:129224216G>A	uc001ljt.2	+	47	4856	c.4792G>A	c.(4792-4794)GAG>AAG	p.E1598K	DOCK1_uc010qun.1_Missense_Mutation_p.E1619K|DOCK1_uc009yaq.2_Missense_Mutation_p.E593K	NM_001380	NP_001371	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	1598	DHR-2.				apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			central_nervous_system(4)|ovary(2)|lung(1)|breast(1)|kidney(1)	9		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		CGAGAGGATGGAGGCCTGTTT	0.507		NA											71	152					0	0	0	0
PHRF1	57661	broad.mit.edu	37	11	608998	608998	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:608998G>T	uc001lqe.2	+	14	3673	c.3542G>T	c.(3541-3543)CGT>CTT	p.R1181L	PHRF1_uc010qwc.1_Missense_Mutation_p.R1180L|PHRF1_uc010qwd.1_Missense_Mutation_p.R1179L|PHRF1_uc010qwe.1_Missense_Mutation_p.R1177L|PHRF1_uc009ybz.1_Missense_Mutation_p.R971L|PHRF1_uc009yca.1_RNA	NM_020901	NP_065952	Q9P1Y6	PHRF1_HUMAN	PHD and ring finger domains 1	1181	Arg-rich.						RNA polymerase binding|zinc ion binding				0						CCTCGGTCCCGTGAGAAGTGG	0.706		NA											4	13					0.00024832	0.000374451	1	0
MUC6	4588	broad.mit.edu	37	11	1017714	1017714	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:1017714G>T	uc001lsw.2	-	31	5138	c.5087C>A	c.(5086-5088)TCA>TAA	p.S1696*		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	mucin 6, gastric	1696	Thr-rich.|1; truncated.|Approximate repeats.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GGAAGTGTGTGAATGTAGGGA	0.557		NA											61	736					1.44e-28	3.02e-28	1	0
TSPAN32	10077	broad.mit.edu	37	11	2335755	2335755	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:2335755G>C	uc001lvy.1	+	6	634	c.497G>C	c.(496-498)GGG>GCG	p.G166A	TSPAN32_uc001lvx.1_Silent_p.G209G|TSPAN32_uc009ydk.1_Missense_Mutation_p.G176A|TSPAN32_uc010qxk.1_Missense_Mutation_p.G201A|TSPAN32_uc009ydl.1_RNA|TSPAN32_uc001lvz.1_Missense_Mutation_p.G136A|TSPAN32_uc001lwb.1_Missense_Mutation_p.G136A|TSPAN32_uc001lwc.1_Missense_Mutation_p.G111A|TSPAN32_uc001lwd.1_5'Flank	NM_139022	NP_620591	Q96QS1	TSN32_HUMAN	tumor-suppressing subtransferable candidate 6	166					cell-cell signaling	integral to membrane				central_nervous_system(1)	1		all_epithelial(84;4.89e-05)|Breast(177;0.000962)|Medulloblastoma(188;0.00106)|Ovarian(85;0.0014)|all_neural(188;0.00791)|Lung NSC(207;0.209)		BRCA - Breast invasive adenocarcinoma(625;0.000533)|LUSC - Lung squamous cell carcinoma(625;0.082)|Lung(200;0.153)		AGCCGTCTGGGGAGCACAGAG	0.647		NA											3	10					0	0	0	0
ART1	417	broad.mit.edu	37	11	3681167	3681167	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:3681167C>A	uc001lye.1	+	3	519	c.418C>A	c.(418-420)CGC>AGC	p.R140S	ART1_uc009yeb.1_Missense_Mutation_p.R140S	NM_004314	NP_004305	P52961	NAR1_HUMAN	ADP-ribosyltransferase 1 precursor	140					protein ADP-ribosylation	anchored to membrane|integral to plasma membrane|sarcoplasmic reticulum membrane	NAD(P)+-protein-arginine ADP-ribosyltransferase activity|NAD+ ADP-ribosyltransferase activity				0		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0351)|LUSC - Lung squamous cell carcinoma(625;0.195)	Becaplermin(DB00102)	TGAGGCGGGCCGCTCCCGGGC	0.667		NA											24	40					2.4e-15	4.64e-15	1	0
OR52I2	143502	broad.mit.edu	37	11	4608507	4608507	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:4608507C>T	uc010qyh.1	+	1	465	c.465C>T	c.(463-465)GCC>GCT	p.A155A		NM_001005170	NP_001005170	Q8NH67	O52I2_HUMAN	olfactory receptor, family 52, subfamily I,	155	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		GCTATGTAGCCATCTGCAAGC	0.488		NA											7	76					0	0	0	0
OR52I1	390037	broad.mit.edu	37	11	4615655	4615655	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:4615655C>T	uc010qyi.1	+	1	387	c.387C>T	c.(385-387)GCC>GCT	p.A129A		NM_001005169	NP_001005169	Q8NGK6	O52I1_HUMAN	olfactory receptor, family 52, subfamily I,	129	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)	2		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;7.98e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		GCTATGTAGCCATCTGCAAGC	0.498		NA											17	34					0	0	0	0
OR51V1	283111	broad.mit.edu	37	11	5221348	5221348	+	Missense_Mutation	SNP	G	G	A	rs151191536		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:5221348G>A	uc010qyz.1	-	1	583	c.583C>T	c.(583-585)CGC>TGC	p.R195C		NM_001004760	NP_001004760	Q9H2C8	O51V1_HUMAN	olfactory receptor, family 51, subfamily V,	195	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.83e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CAGGCTAAGCGGAGAAGATCC	0.398		NA											11	39					0	0	0	0
OR51Q1	390061	broad.mit.edu	37	11	5443437	5443437	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:5443437C>A	uc010qzd.1	+	1	7	c.7C>A	c.(7-9)CAG>AAG	p.Q3K	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004757	NP_001004757	Q8NH59	O51Q1_HUMAN	olfactory receptor, family 51, subfamily Q,	3	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.18e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGTCATGTCCCAGGTGACTAA	0.448		NA											36	77					7.11e-15	1.37e-14	1	0
OR56B1	387748	broad.mit.edu	37	11	5758078	5758078	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:5758078A>G	uc001mbt.1	+	1	332	c.332A>G	c.(331-333)TAT>TGT	p.Y111C	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron|OR56B1_uc001mbs.1_Missense_Mutation_p.Y111C|OR56B1_uc009yev.1_Missense_Mutation_p.Y111C	NM_001005180	NP_001005180	Q8NGI3	O56B1_HUMAN	olfactory receptor, family 56, subfamily B,	111	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.086)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.184)		GCTCAGATTTATGCCATTCAC	0.458		NA											9	32					0	0	0	0
OR52B2	255725	broad.mit.edu	37	11	6191434	6191434	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:6191434G>T	uc010qzy.1	-	1	123	c.123C>A	c.(121-123)GTC>GTA	p.V41V		NM_001004052	NP_001004052	Q96RD2	O52B2_HUMAN	olfactory receptor, family 52, subfamily B,	41	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;3.69e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGTTTCCCAGGACTGCAGTGA	0.478		NA											22	71					7.45e-12	1.37e-11	1	0
SPTY2D1	144108	broad.mit.edu	37	11	18637522	18637522	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:18637522G>T	uc001moy.2	-	3	515	c.299C>A	c.(298-300)CCT>CAT	p.P100H	SPTY2D1_uc010rdi.1_Missense_Mutation_p.P100H	NM_194285	NP_919261	Q68D10	SPT2_HUMAN	SPT2, Suppressor of Ty, domain containing 1	100										breast(1)	1						TTCCTCAATAGGAATCCCATT	0.433		NA											54	87					1.03e-37	2.2e-37	1	0
NAV2	89797	broad.mit.edu	37	11	20065574	20065574	+	Silent	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:20065574T>C	uc010rdm.1	+	14	3385	c.3024T>C	c.(3022-3024)TCT>TCC	p.S1008S	NAV2_uc001mpp.2_Silent_p.S921S|NAV2_uc001mpr.3_Silent_p.S985S|NAV2_uc001mpt.2_Silent_p.S71S|NAV2_uc009yhx.2_Silent_p.S71S|NAV2_uc009yhy.1_5'UTR	NM_145117	NP_660093	Q8IVL1	NAV2_HUMAN	neuron navigator 2 isoform 2	1008						nucleus	ATP binding|helicase activity			skin(4)|ovary(1)|pancreas(1)	6						CCCTGTGGTCTGGTGATGATG	0.527		NA											24	64					0	0	0	0
NAV2	89797	broad.mit.edu	37	11	20066745	20066746	+	Missense_Mutation	DNP	GC	GC	TT	rs140697093	by1000genomes	TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:20066745_20066746GC>TT	uc010rdm.1	+	15	3861_3862	c.3500_3501GC>TT	c.(3499-3501)AGC>ATT	p.S1167I	NAV2_uc001mpp.2_Missense_Mutation_p.S1080I|NAV2_uc001mpr.3_Missense_Mutation_p.S1144I|NAV2_uc001mpt.2_Missense_Mutation_p.S230I|NAV2_uc009yhx.2_Missense_Mutation_p.S230I|NAV2_uc009yhy.1_Missense_Mutation_p.S143I	NM_145117	NP_660093	Q8IVL1	NAV2_HUMAN	neuron navigator 2 isoform 2	1167						nucleus	ATP binding|helicase activity			skin(4)|ovary(1)|pancreas(1)	6						ACTGTCACCAGCAGGTCAGCCA	0.574		NA											19	79					0	0	0	0
SLC6A5	9152	broad.mit.edu	37	11	20623176	20623176	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:20623176G>T	uc001mqd.2	+	2	778	c.505G>T	c.(505-507)GTG>TTG	p.V169L	SLC6A5_uc009yic.2_5'UTR	NM_004211	NP_004202	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter	169	Cytoplasmic (Potential).				synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(2)|breast(1)|skin(1)	4					Glycine(DB00145)	AATCACGTCCGTGCTCCCGGG	0.652		NA											12	31					6.4e-05	9.89e-05	1	0
SLC17A6	57084	broad.mit.edu	37	11	22364872	22364872	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:22364872T>G	uc001mqk.2	+	3	832	c.419T>G	c.(418-420)ATT>AGT	p.I140S		NM_020346	NP_065079	Q9P2U8	VGLU2_HUMAN	solute carrier family 17 (sodium-dependent	140	Helical; (Potential).				sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)|breast(1)	4						ATCACTCAGATTCCGGGAGGC	0.577		NA											28	65					0	0	0	0
KCNA4	3739	broad.mit.edu	37	11	30033418	30033418	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:30033418G>A	uc001msk.2	-	2	1960	c.808C>T	c.(808-810)CGG>TGG	p.R270W		NM_002233	NP_002224	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related	270						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						TCGTCCTCCCGAAACTTCAAC	0.512		NA											22	59					0	0	0	0
CKAP5	9793	broad.mit.edu	37	11	46822845	46822845	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:46822845T>C	uc001ndi.1	-	9	1098	c.988A>G	c.(988-990)AAG>GAG	p.K330E	CKAP5_uc009ylg.1_Missense_Mutation_p.K216E|CKAP5_uc001ndj.1_Missense_Mutation_p.K330E	NM_001008938	NP_001008938	Q14008	CKAP5_HUMAN	colonic and hepatic tumor over-expressed protein	330					cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding|protein binding			ovary(1)|skin(1)	2						TTGGTGTCCTTTCCAACAACC	0.393		NA											16	33					0	0	0	0
OR4A16	81327	broad.mit.edu	37	11	55110887	55110887	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:55110887T>C	uc010rie.1	+	1	211	c.211T>C	c.(211-213)TAT>CAT	p.Y71H		NM_001005274	NP_001005274	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A,	71	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(2)|pancreas(1)	3						GGATGCCATATATTCCACTGC	0.453		NA											44	111					0	0	0	0
OR4C15	81309	broad.mit.edu	37	11	55322574	55322574	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:55322574C>T	uc010rig.1	+	1	792	c.792C>T	c.(790-792)TTC>TTT	p.F264F		NM_001001920	NP_001001920	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C,	210	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TCATAAACTTCTCCTTGTTGC	0.483		NA								HNSCC(20;0.049)			28	89					0	0	0	0
OR4S2	219431	broad.mit.edu	37	11	55419304	55419304	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:55419304A>G	uc001nhs.1	+	1	925	c.925A>G	c.(925-927)AAA>GAA	p.K309E		NM_001004059	NP_001004059	Q8NH73	OR4S2_HUMAN	olfactory receptor, family 4, subfamily S,	309	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.0748)				CTTGGAGGCTAAAGGGAAATA	0.249		NA											49	119					0	0	0	0
OR4C6	219432	broad.mit.edu	37	11	55433323	55433323	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:55433323C>A	uc001nht.3	+	3	946	c.681C>A	c.(679-681)AGC>AGA	p.S227R	OR4C6_uc010rik.1_Missense_Mutation_p.S227R	NM_001004704	NP_001004704	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C,	227	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						AGTCTTACAGCTCTAAAGGGC	0.498		NA											37	99					4.11e-13	7.7e-13	1	0
OR4C6	219432	broad.mit.edu	37	11	55433552	55433552	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:55433552G>T	uc001nht.3	+	3	1175	c.910G>T	c.(910-912)GAG>TAG	p.E304*	OR4C6_uc010rik.1_Nonsense_Mutation_p.E304*	NM_001004704	NP_001004704	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C,	304	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						GATGAAATGGGAGGCTTTGGC	0.408		NA											7	36					1.07e-07	1.81e-07	1	0
OR5D16	390144	broad.mit.edu	37	11	55606250	55606250	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:55606250C>A	uc010rio.1	+	1	23	c.23C>A	c.(22-24)ACG>AAG	p.T8K		NM_001005496	NP_001005496	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D,	8	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_epithelial(135;0.208)				GAGAGAAATACGACATCTGAG	0.413		NA											22	42					1.37e-18	2.75e-18	1	0
OR5D16	390144	broad.mit.edu	37	11	55607036	55607036	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:55607036G>T	uc010rio.1	+	1	809	c.809G>T	c.(808-810)AGG>ATG	p.R270M		NM_001005496	NP_001005496	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D,	270	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_epithelial(135;0.208)				AAAAACTCCAGGCACACAGTC	0.493		NA											21	67					3.62e-10	6.48e-10	1	0
SPRYD5	84767	broad.mit.edu	37	11	55653181	55653181	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:55653181T>C	uc010rip.1	+	2	369	c.277T>C	c.(277-279)TGT>CGT	p.C93R	SPRYD5_uc010riq.1_5'Flank	NM_032681	NP_116070	Q9BSJ1	SPRY5_HUMAN	SPRY domain containing 5	93	B box-type.					intracellular	zinc ion binding				0		all_epithelial(135;0.226)				GGAGCAAATATGTGGGATGCA	0.488		NA											5	44					0	0	0	0
SPRYD5	84767	broad.mit.edu	37	11	55658953	55658953	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:55658953G>T	uc010rip.1	+	7	1296	c.1204G>T	c.(1204-1206)GTT>TTT	p.V402F	SPRYD5_uc010riq.1_Missense_Mutation_p.V259F	NM_032681	NP_116070	Q9BSJ1	SPRY5_HUMAN	SPRY domain containing 5	402	B30.2/SPRY.					intracellular	zinc ion binding				0		all_epithelial(135;0.226)				GGTGCAATATGTTCCAAGACC	0.458		NA											23	65					2.45e-14	4.67e-14	1	0
OR8H3	390152	broad.mit.edu	37	11	55890065	55890065	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:55890065A>G	uc001nii.1	+	1	217	c.217A>G	c.(217-219)AGT>GGT	p.S73G		NM_001005201	NP_001005201	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H,	73	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00693)					TATTGACCTCAGTTACTCAAC	0.443		NA											85	224					0	0	0	0
OR8H3	390152	broad.mit.edu	37	11	55890212	55890212	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:55890212C>G	uc001nii.1	+	1	364	c.364C>G	c.(364-366)CGC>GGC	p.R122G		NM_001005201	NP_001005201	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H,	122	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00693)					GGCCTATGATCGCTATGCAGC	0.463		NA											56	159					0	0	0	0
OR5J2	282775	broad.mit.edu	37	11	55944846	55944846	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:55944846C>A	uc010rjb.1	+	1	753	c.753C>A	c.(751-753)TTC>TTA	p.F251L		NM_001005492	NP_001005492	Q8NH18	OR5J2_HUMAN	olfactory receptor, family 5, subfamily J,	251	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|large_intestine(1)|breast(1)|pancreas(1)	4	Esophageal squamous(21;0.00693)					TGACCATATTCTATGGTACCT	0.453		NA											34	92					2.68e-12	4.94e-12	1	0
OR5T2	219464	broad.mit.edu	37	11	55999944	55999944	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:55999944A>T	uc010rjc.1	-	1	718	c.718T>A	c.(718-720)TAC>AAC	p.Y240N		NM_001004746	NP_001004746	Q8NGG2	OR5T2_HUMAN	olfactory receptor, family 5, subfamily T,	240	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					CCCACAAAGTAGAAGAGTAGA	0.438		NA											35	100					0	0	0	0
OR8K3	219473	broad.mit.edu	37	11	56085963	56085963	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:56085963T>C	uc010rjf.1	+	1	181	c.181T>C	c.(181-183)TTT>CTT	p.F61L		NM_001005202	NP_001005202	Q8NH51	OR8K3_HUMAN	olfactory receptor, family 8, subfamily K,	61	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	Esophageal squamous(21;0.00448)					CCCTATGTACTTTTTTCTCAG	0.383		NA											9	180					0	0	0	0
OR5R1	219479	broad.mit.edu	37	11	56185379	56185379	+	Silent	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:56185379A>T	uc010rji.1	-	1	330	c.330T>A	c.(328-330)ACT>ACA	p.T110T		NM_001004744	NP_001004744	Q8NH85	OR5R1_HUMAN	olfactory receptor, family 5, subfamily R,	110	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					GGAAACACTCAGTGATCATGA	0.453		NA											15	37					0	0	0	0
OR5M3	219482	broad.mit.edu	37	11	56237806	56237807	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:56237806_56237807GG>TT	uc010rjk.1	-	1	167_168	c.167_168CC>AA	c.(166-168)CCC>CAA	p.P56Q		NM_001004742	NP_001004742	Q8NGP4	OR5M3_HUMAN	olfactory receptor, family 5, subfamily M,	56	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					AAAAGTACATGGGGTTGTTAAG	0.396		NA											18	44					0	0	0	0
OR5M1	390168	broad.mit.edu	37	11	56380486	56380486	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:56380486G>C	uc001nja.1	-	1	493	c.493C>G	c.(493-495)CAC>GAC	p.H165D		NM_001004740	NP_001004740	Q8NGP8	OR5M1_HUMAN	olfactory receptor, family 5, subfamily M,	165	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						AAGGATAAGTGAAAGGTTAGC	0.463		NA											20	39					0	0	0	0
OR6Q1	219952	broad.mit.edu	37	11	57799168	57799168	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:57799168C>A	uc010rjz.1	+	1	744	c.744C>A	c.(742-744)CAC>CAA	p.H248Q	OR9Q1_uc001nmj.2_Intron	NM_001005186	NP_001005186	Q8NGQ2	OR6Q1_HUMAN	olfactory receptor, family 6, subfamily Q,	248	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)	1		Breast(21;0.0707)|all_epithelial(135;0.142)				GTGCAGCTCACCTGACTGTGG	0.512		NA											52	139					2.15e-31	4.52e-31	1	0
OR1S2	219958	broad.mit.edu	37	11	57970690	57970690	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:57970690T>C	uc010rkb.1	-	1	964	c.964A>G	c.(964-966)ATT>GTT	p.I322V		NM_001004459	NP_001004459	Q8NGQ3	OR1S2_HUMAN	olfactory receptor, family 1, subfamily S,	322	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(21;0.0589)				AGGGAAGAAATTTTTCTATTG	0.418		NA											55	97					0	0	0	0
GLYATL1	92292	broad.mit.edu	37	11	58714591	58714591	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:58714591C>A	uc001nnf.2	+	4	407	c.31C>A	c.(31-33)CTG>ATG	p.L11M	uc001nng.1_Intron|GLYATL1_uc001nnh.1_Intron|GLYATL1_uc001nni.1_Missense_Mutation_p.L11M|GLYATL1_uc001nnj.1_Missense_Mutation_p.L11M			Q969I3	GLYL1_HUMAN	SubName: Full=Glycine acyltransferase family-C; SubName: Full=Glycine-N-acyltransferase-like 1, isoform CRA_a;	11						mitochondrion	glycine N-acyltransferase activity			ovary(1)	1					Glycine(DB00145)	CCATAAGCTGCTGGCCCTATA	0.478		NA											14	28					1.58e-08	2.73e-08	1	0
MS4A3	932	broad.mit.edu	37	11	59829952	59829952	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:59829952C>A	uc001nom.2	+	3	296	c.168C>A	c.(166-168)ATC>ATA	p.I56I	MS4A3_uc001non.2_Intron|MS4A3_uc001noo.2_Intron	NM_006138	NP_006129	Q96HJ5	MS4A3_HUMAN	membrane-spanning 4-domains, subfamily A, member	56	Helical; (Potential).					endomembrane system|integral to membrane|perinuclear region of cytoplasm	protein binding|receptor activity			ovary(2)|skin(1)	3		all_epithelial(135;0.245)				CCATCCAGATCCTGAATGCAG	0.423		NA											30	80					1.31e-18	2.64e-18	1	0
AHNAK	79026	broad.mit.edu	37	11	62289778	62289778	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:62289778G>C	uc001ntl.2	-	5	12411	c.12111C>G	c.(12109-12111)ATC>ATG	p.I4037M	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	4037					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TGGGGCCCTTGATGTCAACTT	0.493		NA											92	249					0	0	0	0
AHNAK	79026	broad.mit.edu	37	11	62298691	62298691	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:62298691C>G	uc001ntl.2	-	5	3498	c.3198G>C	c.(3196-3198)AAG>AAC	p.K1066N	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	1066					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				GCAAAGACATCTTAGGAGCTC	0.443		NA											23	106					0	0	0	0
PLCB3	5331	broad.mit.edu	37	11	64022704	64022704	+	Splice_Site	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:64022704A>T	uc001nzb.2	+	5	388	c.388_splice	c.e5-2	p.V130_splice	PLCB3_uc009ypg.1_Splice_Site_p.V130_splice|PLCB3_uc009yph.1_Splice_Site_p.V63_splice|PLCB3_uc009ypi.2_Splice_Site_p.V130_splice	NM_000932	NP_000923	Q01970	PLCB3_HUMAN	phospholipase C beta 3						intracellular signal transduction|lipid catabolic process|synaptic transmission	cytosol	calcium ion binding|calmodulin binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|pancreas(1)	2						CTGGCCCCCCAGGTCTGGTCT	0.627		NA											8	10					0	0	0	0
NRXN2	9379	broad.mit.edu	37	11	64390225	64390225	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:64390225C>A	uc001oap.2	-	6	1546	c.1035G>T	c.(1033-1035)CAG>CAT	p.Q345H	NRXN2_uc001oar.2_Missense_Mutation_p.Q1391H|NRXN2_uc001oas.2_Missense_Mutation_p.Q1321H|NRXN2_uc001oao.2_Missense_Mutation_p.Q31H|NRXN2_uc001oaq.2_Missense_Mutation_p.Q1058H	NM_138734	NP_620063	P58401	NRX2B_HUMAN	neurexin 2 isoform beta precursor	345	Extracellular (Potential).				cell adhesion	integral to membrane				upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)|ovary(2)|kidney(1)|pancreas(1)	10						GGGGCCTCACCTGGGTGGTGC	0.488		NA											13	62					0.00185496	0.00272211	1	0
CDC42EP2	10435	broad.mit.edu	37	11	65088571	65088571	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:65088571A>G	uc001odl.2	+	2	652	c.202A>G	c.(202-204)ACC>GCC	p.T68A		NM_006779	NP_006770	O14613	BORG1_HUMAN	Cdc42 effector protein 2	68					actin filament organization|positive regulation of actin filament polymerization|positive regulation of pseudopodium assembly|regulation of cell shape	cytoplasm|cytoskeleton|endomembrane system|plasma membrane	GTP-Rho binding|Rho GTPase activator activity				0						CCTGCCGGGGACCATGGTGGA	0.647		NA											24	54					0	0	0	0
PACS1	55690	broad.mit.edu	37	11	66003368	66003368	+	Splice_Site	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:66003368G>A	uc001oha.1	+	19	2342	c.2208_splice	c.e19-1	p.F736_splice	PACS1_uc010rou.1_Splice_Site_p.F272_splice	NM_018026	NP_060496	Q6VY07	PACS1_HUMAN	phosphofurin acidic cluster sorting protein 1						interspecies interaction between organisms|regulation of defense response to virus by virus|viral reproduction	cytosol	protein binding			ovary(6)	6						TCTCCCAACAGCCCTGATGAA	0.532		NA											37	115					0	0	0	0
RBM14	10432	broad.mit.edu	37	11	66392979	66392979	+	Silent	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:66392979A>T	uc001oit.2	+	2	1771	c.1632A>T	c.(1630-1632)CCA>CCT	p.P544P	RBM14_uc009yrh.2_Intron|RBM14_uc009yri.2_Intron|RBM4_uc009yrj.2_Intron|RBM4_uc009yrk.2_Intron	NM_006328	NP_006319	Q96PK6	RBM14_HUMAN	RNA binding motif protein 14	544	Ala-rich.				DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|histone deacetylation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus	mediator complex|ribonucleoprotein complex|transcription factor complex	ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|protein binding, bridging|RNA binding|RNA polymerase II transcription cofactor activity			ovary(2)|central_nervous_system(1)	3						GCGGCCAGCCAGGCAATGCCT	0.657		NA											20	46					0	0	0	0
CORO1B	57175	broad.mit.edu	37	11	67206199	67206199	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:67206199G>T	uc001olj.1	-	9	1323	c.1287C>A	c.(1285-1287)CCC>CCA	p.P429P	PTPRCAP_uc001oli.1_5'Flank|CORO1B_uc009yrs.1_RNA|CORO1B_uc001olk.1_Silent_p.P429P|CORO1B_uc009yrt.1_RNA|CORO1B_uc009yru.1_RNA|CORO1B_uc001oll.1_Silent_p.P429P	NM_020441	NP_065174	Q9BR76	COR1B_HUMAN	coronin, actin binding protein, 1B	429					actin cytoskeleton organization	actin cytoskeleton|cytoplasm	actin filament binding			large_intestine(1)|ovary(1)	2			BRCA - Breast invasive adenocarcinoma(15;3.26e-06)			TGGTGGAGGCGGGGGCCCCTA	0.716		NA											3	7					1.24e-05	1.96e-05	1	0
CPT1A	1374	broad.mit.edu	37	11	68571469	68571469	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:68571469C>A	uc001oog.3	-	5	724	c.554G>T	c.(553-555)AGG>ATG	p.R185M	CPT1A_uc001oof.3_Missense_Mutation_p.R185M|CPT1A_uc009ysj.2_Missense_Mutation_p.R185M	NM_001876	NP_001867	P50416	CPT1A_HUMAN	carnitine palmitoyltransferase 1A liver isoform	185	Cytoplasmic (Potential).				carnitine shuttle|fatty acid beta-oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			skin(2)	2	Esophageal squamous(3;3.28e-14)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.142)		L-Carnitine(DB00583)|Perhexiline(DB01074)	CACACCTACCCTGTTCACAGT	0.512		NA											21	44					3.88e-16	7.61e-16	1	0
SLCO2B1	11309	broad.mit.edu	37	11	74911282	74911282	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:74911282A>G	uc001owb.2	+	11	2000	c.1613A>G	c.(1612-1614)AAC>AGC	p.N538S	SLCO2B1_uc010rrq.1_Missense_Mutation_p.N283S|SLCO2B1_uc010rrr.1_Missense_Mutation_p.N394S|SLCO2B1_uc010rrs.1_Missense_Mutation_p.N422S|SLCO2B1_uc001owc.2_Missense_Mutation_p.N311S|SLCO2B1_uc001owd.2_Missense_Mutation_p.N516S	NM_007256	NP_009187	O94956	SO2B1_HUMAN	solute carrier organic anion transporter family,	538	Extracellular (Potential).|Kazal-like.				sodium-independent organic anion transport	integral to membrane	sodium-independent organic anion transmembrane transporter activity			ovary(1)|breast(1)	2					Ergoloid mesylate(DB01049)	TTCTACACCAACTGCAGCTGC	0.622		NA											19	87					0	0	0	0
PCF11	51585	broad.mit.edu	37	11	82880066	82880066	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:82880066C>T	uc001ozx.3	+	8	3034	c.2689C>T	c.(2689-2691)CAG>TAG	p.Q897*	PCF11_uc010rsu.1_Nonsense_Mutation_p.Q1028*	NM_015885	NP_056969	O94913	PCF11_HUMAN	pre-mRNA cleavage complex II protein Pcf11	897	Gly-rich.				mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				ovary(1)	1						ACCTCATGGTCAGCCTGTGGG	0.552		NA											20	38					0	0	0	0
CREBZF	58487	broad.mit.edu	37	11	85375697	85375697	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:85375697C>A	uc001pas.2	-	1	486	c.223G>T	c.(223-225)GTG>TTG	p.V75L	CREBZF_uc010rtc.1_RNA|CREBZF_uc010rtd.1_RNA	NM_001039618	NP_001034707	Q9NS37	ZHANG_HUMAN	HCF-binding transcription factor Zhangfei	75					negative regulation of gene expression, epigenetic|negative regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|response to virus	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)				GGCGCGCGCACGGCCACGCCG	0.706		NA											38	76					2.05e-20	4.17e-20	1	0
SYTL2	54843	broad.mit.edu	37	11	85420476	85420476	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:85420476T>A	uc010rth.1	-	12	2174	c.1898A>T	c.(1897-1899)CAG>CTG	p.Q633L	SYTL2_uc010rtg.1_Missense_Mutation_p.Q634L|SYTL2_uc010rti.1_Missense_Mutation_p.Q609L|SYTL2_uc010rtj.1_Missense_Mutation_p.Q601L|SYTL2_uc001pav.2_Missense_Mutation_p.Q75L|SYTL2_uc010rte.1_Missense_Mutation_p.Q35L|SYTL2_uc001pax.2_Missense_Mutation_p.Q75L|SYTL2_uc001paz.2_5'UTR|SYTL2_uc001pba.2_Missense_Mutation_p.Q18L|SYTL2_uc001pay.2_Missense_Mutation_p.Q64L|SYTL2_uc001paw.2_Missense_Mutation_p.Q35L|SYTL2_uc009yvj.2_RNA|SYTL2_uc001pbd.2_Missense_Mutation_p.Q931L|SYTL2_uc001pbb.2_Missense_Mutation_p.Q971L|SYTL2_uc001pbc.2_Missense_Mutation_p.Q955L|SYTL2_uc010rtf.1_Missense_Mutation_p.Q451L	NM_001162951	NP_001156423	Q9HCH5	SYTL2_HUMAN	synaptotagmin-like 2 isoform g	633	C2 1.				intracellular protein transport|vesicle docking involved in exocytosis	exocytic vesicle|extrinsic to plasma membrane|melanosome|membrane fraction	neurexin binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|Rab GTPase binding			ovary(2)|large_intestine(1)	3		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)		KIRC - Kidney renal clear cell carcinoma(183;0.202)|Kidney(183;0.237)		AATTGCAAACTGAATATTTCC	0.413		NA											25	65					0	0	0	0
UBTFL1	642623	broad.mit.edu	37	11	89819843	89819843	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:89819843G>A	uc010rub.1	+	1	726	c.726G>A	c.(724-726)ATG>ATA	p.M242I		NM_001143975	NP_001137447	P0CB47	UBFL1_HUMAN	upstream binding transcription factor, RNA	242	HMG box 2.				multicellular organismal development	cytoplasm|nucleus	DNA binding				0						GTAAAGAGATGCAACATTTGT	0.483		NA											50	101					0	0	0	0
FAT3	120114	broad.mit.edu	37	11	92531613	92531613	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:92531613G>C	uc001pdj.3	+	9	5451	c.5434G>C	c.(5434-5436)GTG>CTG	p.V1812L		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	1812	Cadherin 16.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TGCTCTGCTTGTGTATCAGAT	0.478		NA								TCGA Ovarian(4;0.039)			10	23					0	0	0	0
FAT3	120114	broad.mit.edu	37	11	92533403	92533403	+	Silent	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:92533403C>G	uc001pdj.3	+	9	7241	c.7224C>G	c.(7222-7224)CCC>CCG	p.P2408P		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	2408	Cadherin 22.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				AATTAGCCCCCCGGGGCCATT	0.443		NA								TCGA Ovarian(4;0.039)			42	89					0	0	0	0
TRPC6	7225	broad.mit.edu	37	11	101344380	101344380	+	Silent	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:101344380C>G	uc001pgk.3	-	7	2294	c.1869G>C	c.(1867-1869)CTG>CTC	p.L623L	TRPC6_uc009ywy.2_Silent_p.L507L|TRPC6_uc009ywz.1_Silent_p.L568L	NM_004621	NP_004612	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel,	623	Cytoplasmic (Potential).				axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		GTGATATCTGCAGAGGTCCAA	0.348		NA											17	60					0	0	0	0
KIAA1377	57562	broad.mit.edu	37	11	101834193	101834193	+	Silent	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:101834193T>C	uc001pgm.2	+	6	2697	c.2427T>C	c.(2425-2427)AAT>AAC	p.N809N	KIAA1377_uc001pgn.2_Silent_p.N765N|KIAA1377_uc010run.1_Silent_p.N610N|KIAA1377_uc009yxa.1_Silent_p.N610N	NM_020802	NP_065853	Q9P2H0	K1377_HUMAN	hypothetical protein LOC57562	809							protein binding			breast(2)|ovary(1)|central_nervous_system(1)	4	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)		CTACATCAAATATTAGAAGTG	0.348		NA											9	28					0	0	0	0
MMP20	9313	broad.mit.edu	37	11	102477375	102477375	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:102477375G>C	uc001phc.2	-	6	857	c.844C>G	c.(844-846)CTG>GTG	p.L282V		NM_004771	NP_004762	O60882	MMP20_HUMAN	matrix metalloproteinase 20 preproprotein	282					proteolysis|regulation of enamel mineralization	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|protein binding|zinc ion binding			urinary_tract(1)|skin(1)	2	all_cancers(8;8.95e-05)|all_epithelial(12;0.00227)|Lung NSC(15;0.139)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0216)|Lung(13;0.0711)|all cancers(10;0.0889)|LUSC - Lung squamous cell carcinoma(19;0.13)	BRCA - Breast invasive adenocarcinoma(274;0.0161)		GCATGGGGCAGAGTGGGCTTC	0.522		NA											19	47					0	0	0	0
DDI1	414301	broad.mit.edu	37	11	103908508	103908508	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:103908508A>G	uc001phr.2	+	1	1201	c.958A>G	c.(958-960)ATA>GTA	p.I320V	PDGFD_uc001php.2_Intron|PDGFD_uc001phq.2_Intron	NM_001001711	NP_001001711	Q8WTU0	DDI1_HUMAN	DDI1, DNA-damage inducible 1, homolog 1	320					proteolysis		aspartic-type endopeptidase activity			large_intestine(3)|upper_aerodigestive_tract(1)|pancreas(1)	5		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00648)|Melanoma(852;0.055)|all_neural(303;0.164)		BRCA - Breast invasive adenocarcinoma(274;0.00128)|Epithelial(105;0.0631)|all cancers(92;0.169)		CTCTTTCTCCATACTTGAGGA	0.453		NA											32	60					0	0	0	0
KBTBD3	143879	broad.mit.edu	37	11	105925058	105925058	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:105925058C>A	uc001pja.2	-	4	998	c.358G>T	c.(358-360)GAT>TAT	p.D120Y	KBTBD3_uc001pjb.2_Missense_Mutation_p.D120Y|KBTBD3_uc009yxm.2_Missense_Mutation_p.D41Y	NM_198439	NP_940841	Q8NAB2	KBTB3_HUMAN	BTB and kelch domain containing 3	116										ovary(1)|central_nervous_system(1)	2		Melanoma(852;0.000878)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0321)		BRCA - Breast invasive adenocarcinoma(274;5.43e-05)|Epithelial(105;0.00418)|all cancers(92;0.0299)		TCCACATTATCATCTGTTATT	0.328		NA											8	25					0.00307968	0.00445776	1	0
CWF19L2	143884	broad.mit.edu	37	11	107224343	107224343	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:107224343C>A	uc010rvp.1	-	13	2022	c.1992G>T	c.(1990-1992)GAG>GAT	p.E664D	CWF19L2_uc001pjh.3_RNA|CWF19L2_uc009yxo.2_RNA	NM_152434	NP_689647	Q2TBE0	C19L2_HUMAN	CWF19-like 2, cell cycle control	664	Potential.						catalytic activity				0		Melanoma(852;1.75e-05)|all_epithelial(67;6.27e-05)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0258)		Epithelial(105;7.18e-06)|BRCA - Breast invasive adenocarcinoma(274;1.65e-05)|all cancers(92;1.76e-05)		GACTCCGATGCTCAGCAATAG	0.413		NA											24	53					2.22e-12	4.09e-12	1	0
ZBTB16	7704	broad.mit.edu	37	11	113934661	113934661	+	Silent	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:113934661C>G	uc001pop.2	+	2	903	c.639C>G	c.(637-639)CTC>CTG	p.L213L	ZBTB16_uc001poo.1_Silent_p.L213L|ZBTB16_uc001poq.2_Silent_p.L213L	NM_006006	NP_005997	Q05516	ZBT16_HUMAN	promyelocytic leukemia zinc finger protein	213					apoptosis|central nervous system development|mesonephros development|myeloid cell differentiation|negative regulation of myeloid cell differentiation|negative regulation of transcription, DNA-dependent	nuclear speck|PML body|transcriptional repressor complex	protein homodimerization activity|zinc ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(61;3.79e-18)|all_epithelial(67;2.32e-10)|all_hematologic(158;2.96e-05)|Melanoma(852;0.000362)|Acute lymphoblastic leukemia(157;0.00108)|Breast(348;0.0104)|all_neural(223;0.0294)|Prostate(24;0.0318)|Medulloblastoma(222;0.0438)		BRCA - Breast invasive adenocarcinoma(274;6.75e-06)|Epithelial(105;0.000181)|all cancers(92;0.0018)		GACAGTCTCTCCTGCAGGGAA	0.597		NA											15	33					0	0	0	0
FAM55A	120400	broad.mit.edu	37	11	114401134	114401134	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:114401134C>T	uc001ppa.2	-	3	587	c.170G>A	c.(169-171)GGC>GAC	p.G57D	FAM55A_uc010rxd.1_5'UTR|FAM55A_uc001ppb.1_Missense_Mutation_p.G199D	NM_152315	NP_689528	Q8N323	FA55A_HUMAN	hypothetical protein LOC120400	199						extracellular region					0		all_cancers(61;8.53e-16)|all_epithelial(67;1.71e-08)|all_hematologic(158;3.05e-05)|Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0194)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0906)		BRCA - Breast invasive adenocarcinoma(274;3.02e-06)|Epithelial(105;0.000144)|all cancers(92;0.00106)		TTTATCATAGCCTTGGTTCCT	0.498		NA											21	61					0	0	0	0
CADM1	23705	broad.mit.edu	37	11	115080341	115080341	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:115080341G>T	uc001ppi.3	-	8	1160	c.1031C>A	c.(1030-1032)ACC>AAC	p.T344N	CADM1_uc001ppf.3_Intron|CADM1_uc001ppk.3_Intron|CADM1_uc001ppj.3_Intron|CADM1_uc001pph.3_Missense_Mutation_p.T96N	NM_014333	NP_055148	Q9BY67	CADM1_HUMAN	immunoglobulin superfamily, member 4D isoform 1	344	Extracellular (Potential).			PPTTIPPPTTTTTTTTTTTTTILTIIT -> TTATTEPAVH GLTQLPNSAEELDSEDLS (in Ref. 3; BAC11657).	adherens junction organization|apoptosis|cell differentiation|cell junction assembly|cell recognition|detection of stimulus|heterophilic cell-cell adhesion|homophilic cell adhesion|multicellular organismal development|positive regulation of cytokine secretion|spermatogenesis|susceptibility to natural killer cell mediated cytotoxicity	basolateral plasma membrane|cell-cell junction|integral to membrane	PDZ domain binding|protein C-terminus binding|protein homodimerization activity|receptor binding			ovary(2)	2	all_hematologic(175;0.0628)	all_cancers(61;2.98e-14)|all_epithelial(67;2.64e-08)|all_hematologic(158;0.000154)|Melanoma(852;0.000952)|Acute lymphoblastic leukemia(157;0.00101)|Breast(348;0.0102)|Medulloblastoma(222;0.0429)|Prostate(24;0.145)|all_neural(223;0.237)		BRCA - Breast invasive adenocarcinoma(274;5.01e-06)|Epithelial(105;0.000305)|all cancers(92;0.00303)		ggtggtggtggtggttgttgt	0.274		NA											14	38					4.38e-07	7.3e-07	1	0
DSCAML1	57453	broad.mit.edu	37	11	117303127	117303127	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:117303127G>C	uc001prh.1	-	30	5302	c.5300C>G	c.(5299-5301)CCA>CGA	p.P1767R		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1707	Cytoplasmic (Potential).				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		GATGAGGGTTGGGTGGTGCAA	0.577		NA											14	35					0	0	0	0
DSCAML1	57453	broad.mit.edu	37	11	117332289	117332289	+	Missense_Mutation	SNP	C	C	A	rs142275732		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:117332289C>A	uc001prh.1	-	18	3471	c.3469G>T	c.(3469-3471)GTC>TTC	p.V1157F		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1097	Fibronectin type-III 3.|Extracellular (Potential).				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		AGGGCCCGGACGTTCTCAGGG	0.612		NA											17	47					2.46e-09	4.32e-09	1	0
MLL	4297	broad.mit.edu	37	11	118347536	118347536	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:118347536C>A	uc001pta.2	+	4	3196	c.3173C>A	c.(3172-3174)TCA>TAA	p.S1058*	MLL_uc001ptb.2_Nonsense_Mutation_p.S1058*|MLL_uc001ptd.1_Nonsense_Mutation_p.S50*	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	1058					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		GAAAGTGACTCATCAGAGACC	0.438		NA	T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								21	62					4.63e-17	9.15e-17	1	0
THY1	7070	broad.mit.edu	37	11	119290994	119290994	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:119290994G>T	uc001pwq.2	-	2	174	c.140C>A	c.(139-141)CCC>CAC	p.P47H	uc001pwo.2_Intron|uc001pwp.1_Intron|THY1_uc001pwr.2_Missense_Mutation_p.P47H|THY1_uc001pws.2_RNA	NM_006288	NP_006279	P04216	THY1_HUMAN	Thy-1 cell surface antigen preproprotein	47	Ig-like V-type.				angiogenesis|cell-cell adhesion|cytoskeleton organization|focal adhesion assembly|negative regulation of axonogenesis|negative regulation of cell migration|negative regulation of protein kinase activity|negative regulation of T cell receptor signaling pathway|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of T cell activation|retinal cone cell development|T cell receptor signaling pathway	endoplasmic reticulum|growth cone|integral to plasma membrane|membrane raft	GPI anchor binding|integrin binding|Rho GTPase activator activity				0		Medulloblastoma(222;0.0523)|Breast(348;0.174)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.83e-05)		GTACTGGATGGGTGAACTGCT	0.587		NA											38	96					1.5e-21	3.06e-21	1	0
POU2F3	25833	broad.mit.edu	37	11	120180221	120180221	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:120180221C>A	uc001pxc.2	+	10	1096	c.994C>A	c.(994-996)CGA>AGA	p.R332R	POU2F3_uc010rzk.1_Silent_p.R286R|POU2F3_uc010rzl.1_Silent_p.R262R|POU2F3_uc001pxe.1_Silent_p.R117R	NM_014352	NP_055167	Q9UKI9	PO2F3_HUMAN	POU transcription factor	332	Homeobox.				negative regulation by host of viral transcription	cytoplasm	sequence-specific DNA binding	p.R332*(1)		ovary(1)|skin(1)	2		Breast(109;0.0011)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;6.85e-06)		GTTCTGCAACCGACGCCAAAA	0.557		NA											19	41					1.34e-09	2.36e-09	1	0
TECTA	7007	broad.mit.edu	37	11	120998532	120998532	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:120998532G>T	uc010rzo.1	+	8	1846	c.1846G>T	c.(1846-1848)GAC>TAC	p.D616Y		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	616	TIL 1.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		CACATGCTCCGACCTGACGGC	0.642		NA											26	70					1.55e-18	3.12e-18	1	0
SORL1	6653	broad.mit.edu	37	11	121495940	121495940	+	Missense_Mutation	SNP	G	G	C	rs149393026	byFrequency	TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:121495940G>C	uc001pxx.2	+	46	6398	c.6318G>C	c.(6316-6318)CAG>CAC	p.Q2106H	SORL1_uc010rzp.1_Missense_Mutation_p.Q952H|SORL1_uc010rzq.1_Missense_Mutation_p.Q721H	NM_003105	NP_003096	Q92673	SORL_HUMAN	sortilin-related receptor containing LDLR class	2106	Extracellular (Potential).|Fibronectin type-III 6.				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			ovary(5)|breast(4)|large_intestine(2)|skin(2)|central_nervous_system(1)|pancreas(1)	15		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		TTGGCAACCAGATCTGTGGGG	0.468		NA											23	70					0	0	0	0
OR6X1	390260	broad.mit.edu	37	11	123624645	123624645	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:123624645T>A	uc010rzy.1	-	1	582	c.582A>T	c.(580-582)GAA>GAT	p.E194D		NM_001005188	NP_001005188	Q8NH79	OR6X1_HUMAN	olfactory receptor, family 6, subfamily X,	194	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		CGCCCAGGAGTTCCAAAATGC	0.438		NA											28	70					0	0	0	0
OR8B3	390271	broad.mit.edu	37	11	124266529	124266529	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:124266529G>A	uc010saj.1	-	1	719	c.719C>T	c.(718-720)ACT>ATT	p.T240I	OR8B2_uc001qab.3_Intron	NM_001005467	NP_001005467	Q8NGG8	OR8B3_HUMAN	olfactory receptor, family 8, subfamily B,	240	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		AGAGCTACAAGTACTGAAGGC	0.383		NA											24	92					0	0	0	0
OR8B8	26493	broad.mit.edu	37	11	124310451	124310451	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:124310451G>A	uc010sal.1	-	1	531	c.531C>T	c.(529-531)TAC>TAT	p.Y177Y		NM_012378	NP_036510	Q15620	OR8B8_HUMAN	olfactory receptor, family 8, subfamily B,	177	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		TGTCACACATGTAGTGGTTGA	0.502		NA											26	54					0	0	0	0
ROBO4	54538	broad.mit.edu	37	11	124756439	124756439	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:124756439G>C	uc001qbg.2	-	16	2855	c.2715C>G	c.(2713-2715)CAC>CAG	p.H905Q	ROBO4_uc010sas.1_Missense_Mutation_p.H760Q|ROBO4_uc001qbh.2_3'UTR|ROBO4_uc001qbi.2_Missense_Mutation_p.H463Q	NM_019055	NP_061928	Q8WZ75	ROBO4_HUMAN	roundabout homolog 4, magic roundabout	905					angiogenesis|cell differentiation	integral to membrane	receptor activity			ovary(1)|skin(1)	2	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		CCCGGGCAAAGTGAGCATCAG	0.602		NA											13	51					0	0	0	0
ROBO4	54538	broad.mit.edu	37	11	124765699	124765699	+	Silent	SNP	C	C	G	rs143848676		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:124765699C>G	uc001qbg.2	-	5	929	c.789G>C	c.(787-789)GCG>GCC	p.A263A	ROBO4_uc010sas.1_Silent_p.A118A|ROBO4_uc001qbh.2_Silent_p.A153A|ROBO4_uc001qbi.2_5'Flank|ROBO4_uc010sat.1_5'Flank	NM_019055	NP_061928	Q8WZ75	ROBO4_HUMAN	roundabout homolog 4, magic roundabout	263	Fibronectin type-III 1.				angiogenesis|cell differentiation	integral to membrane	receptor activity			ovary(1)|skin(1)	2	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		TGAGCCACACCGCCGGTCTAG	0.597		NA											36	46					0	0	0	0
SNX19	399979	broad.mit.edu	37	11	130773227	130773227	+	Silent	SNP	T	T	C	rs138603150		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:130773227T>C	uc001qgk.3	-	8	3044	c.2496A>G	c.(2494-2496)CTA>CTG	p.L832L	SNX19_uc009zcw.2_Silent_p.L69L|SNX19_uc010sce.1_Silent_p.L212L|SNX19_uc010scf.1_Silent_p.L275L|SNX19_uc010scg.1_Silent_p.L69L	NM_014758	NP_055573	Q92543	SNX19_HUMAN	sorting nexin 19	832					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			ovary(2)|lung(2)	4	all_hematologic(175;0.0597)	Lung NSC(97;0.000272)|all_lung(97;0.000608)|Breast(109;0.000962)|all_neural(223;0.0298)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;0.0195)|Lung(977;0.233)		ACTGTTCTGTTAGTAGCAAGA	0.448		NA											12	34					0	0	0	0
IGSF9B	22997	broad.mit.edu	37	11	133794770	133794770	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:133794770G>T	uc001qgx.3	-	15	2295	c.2064C>A	c.(2062-2064)GCC>GCA	p.A688A	IGSF9B_uc001qgy.1_Silent_p.A530A	NM_014987	NP_055802	Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	688	Fibronectin type-III 2.|Extracellular (Potential).					integral to membrane|plasma membrane					0	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		CCTGCATGACGGCCAGAACCC	0.577		NA											37	134					3.09e-21	6.31e-21	1	0
WNT5B	81029	broad.mit.edu	37	12	1755062	1755062	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:1755062G>T	uc009zdq.2	+	5	966	c.724G>T	c.(724-726)GGG>TGG	p.G242W	WNT5B_uc001qjj.2_Missense_Mutation_p.G242W|WNT5B_uc001qjk.2_Missense_Mutation_p.G242W|WNT5B_uc001qjl.2_Missense_Mutation_p.G242W	NM_032642	NP_116031	Q9H1J7	WNT5B_HUMAN	wingless-type MMTV integration site family,	242					angiogenesis|anterior/posterior pattern formation|cell migration involved in gastrulation|cellular response to retinoic acid|chondrocyte differentiation|convergent extension involved in axis elongation|convergent extension involved in gastrulation|dorsal/ventral axis specification|endocrine pancreas development|fat cell differentiation|lens fiber cell development|negative regulation of canonical Wnt receptor signaling pathway|neuron differentiation|positive regulation of cell migration|positive regulation of fat cell differentiation|respiratory system development|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled-2 binding			skin(1)	1	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00109)			CCGCAAGGTCGGGGACCGGCT	0.662		NA											28	50					6.13e-19	1.24e-18	1	0
CD163	9332	broad.mit.edu	37	12	7653975	7653975	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:7653975C>G	uc001qsz.3	-	3	345	c.217G>C	c.(217-219)GGA>CGA	p.G73R	CD163_uc001qta.3_Missense_Mutation_p.G73R|CD163_uc009zfw.2_Missense_Mutation_p.G73R	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	73	SRCR 1.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						CACACCGTTCCCCACTCCTCC	0.502		NA											36	95					0	0	0	0
RIMKLB	57494	broad.mit.edu	37	12	8866600	8866600	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:8866600G>T	uc001quu.2	+	2	389	c.138G>T	c.(136-138)ATG>ATT	p.M46I	RIMKLB_uc009zgf.1_RNA|RIMKLB_uc001qux.2_Missense_Mutation_p.M46I|RIMKLB_uc010sgl.1_Missense_Mutation_p.M46I|RIMKLB_uc001quw.2_Missense_Mutation_p.M46I	NM_020734	NP_065785	Q9ULI2	RIMKB_HUMAN	ribosomal modification protein rimK-like family	46					protein modification process	cytoplasm	acid-amino acid ligase activity|ATP binding|metal ion binding				0						CTGTGGTGATGGATGAGGTGG	0.428		NA											17	26					5.01e-05	7.78e-05	1	0
PRH1	5554	broad.mit.edu	37	12	11034876	11034876	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:11034876C>A	uc001qzc.2	-	8	1047	c.459G>T	c.(457-459)GGG>GGT	p.G153G	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_RNA|PRB4_uc001qzf.1_Intron	NM_006250	NP_006241	P02810	PRPC_HUMAN	proline-rich protein HaeIII subfamily 1	153						extracellular space	protein binding				0				BRCA - Breast invasive adenocarcinoma(232;0.245)		GTGGGCGGCCCCCTTGGGGAG	0.587		NA											32	107					4.76e-42	1.01e-41	1	0
GUCY2C	2984	broad.mit.edu	37	12	14796620	14796620	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:14796620G>T	uc001rcd.2	-	17	1955	c.1818C>A	c.(1816-1818)TCC>TCA	p.S606S		NM_004963	NP_004954	P25092	GUC2C_HUMAN	guanylate cyclase 2C precursor	606	Cytoplasmic (Potential).|Protein kinase.				intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			ovary(4)|skin(2)	6						CTGTCTTACTGGAGTGCAGAT	0.373		NA											20	89					2.38e-13	4.46e-13	1	0
PIK3C2G	5288	broad.mit.edu	37	12	18435606	18435606	+	Silent	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:18435606T>C	uc001rdt.2	+	2	707	c.591T>C	c.(589-591)CAT>CAC	p.H197H	PIK3C2G_uc010sia.1_RNA|PIK3C2G_uc010sib.1_Silent_p.H197H|PIK3C2G_uc010sic.1_5'UTR	NM_004570	NP_004561	O75747	P3C2G_HUMAN	phosphoinositide-3-kinase, class 2 gamma	197					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity	p.H197L(1)		lung(8)|central_nervous_system(6)|breast(3)|stomach(2)|ovary(2)	21		Hepatocellular(102;0.194)				GGAGTGGACATGTGAACATTG	0.383		NA											48	130					0	0	0	0
SLCO1B1	10599	broad.mit.edu	37	12	21349914	21349914	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:21349914G>A	uc001req.3	+	8	866	c.762G>A	c.(760-762)TGG>TGA	p.W254*		NM_006446	NP_006437	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family,	254	Extracellular (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity			ovary(3)|skin(3)|pancreas(1)|central_nervous_system(1)	8					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	ATTCTCGATGGGTTGGAGCTT	0.358		NA											40	96					0	0	0	0
KIAA0528	9847	broad.mit.edu	37	12	22680700	22680700	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:22680700C>A	uc001rfq.2	-	4	532	c.304G>T	c.(304-306)GCA>TCA	p.A102S	KIAA0528_uc010sir.1_5'UTR|KIAA0528_uc010sis.1_Missense_Mutation_p.A102S|KIAA0528_uc010sit.1_Missense_Mutation_p.A102S|KIAA0528_uc010siu.1_Missense_Mutation_p.A102S|KIAA0528_uc001rfr.2_Missense_Mutation_p.A102S|KIAA0528_uc009ziy.1_Missense_Mutation_p.A102S	NM_014802	NP_055617	Q86YS7	K0528_HUMAN	hypothetical protein LOC9847	102							protein binding			ovary(1)|large_intestine(1)|breast(1)|central_nervous_system(1)	4						ATGACTGTTGCAGCTTCACTA	0.323		NA											23	67					2.8e-10	5.02e-10	1	0
OVCH1	341350	broad.mit.edu	37	12	29631793	29631793	+	Silent	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:29631793T>C	uc001rix.1	-	9	1044	c.1044A>G	c.(1042-1044)TTA>TTG	p.L348L		NM_183378	NP_899234	Q7RTY7	OVCH1_HUMAN	ovochymase 1 precursor	348	CUB 1.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			ovary(3)|central_nervous_system(3)|pancreas(3)|large_intestine(1)	10	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					TGCTTGATCGTAAAGATACAT	0.303		NA											8	25					0	0	0	0
LRRK2	120892	broad.mit.edu	37	12	40692113	40692113	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:40692113G>C	uc001rmg.3	+	24	3286	c.3165G>C	c.(3163-3165)TTG>TTC	p.L1055F	LRRK2_uc001rmh.1_Missense_Mutation_p.L677F|LRRK2_uc009zjw.2_5'UTR	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	1055	LRR 3.				activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				CTTATTTGTTGAAAATGAGTT	0.333		NA											15	41					0	0	0	0
DBX2	440097	broad.mit.edu	37	12	45429829	45429829	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:45429829G>C	uc001rok.1	-	2	644	c.472C>G	c.(472-474)CGC>GGC	p.R158G		NM_001004329	NP_001004329	Q6ZNG2	DBX2_HUMAN	developing brain homeobox 2	158						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Lung SC(27;0.192)	Lung NSC(34;0.142)		GBM - Glioblastoma multiforme(48;0.0515)		gatgcagggcgccgacaggac	0.109		NA											6	13					0	0	0	0
MLL2	8085	broad.mit.edu	37	12	49438025	49438025	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:49438025C>A	uc001rta.3	-	21	5146	c.5146G>T	c.(5146-5148)GCA>TCA	p.A1716S		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	1716					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TCCGCCTGTGCAGCAGGCCCC	0.617		NA	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)	OREG0021780	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	24					7.48e-07	1.24e-06	1	0
MLL2	8085	broad.mit.edu	37	12	49447314	49447314	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:49447314C>T	uc001rta.3	-	6	784	c.784G>A	c.(784-786)GCC>ACC	p.A262T		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	262	Cys-rich.|PHD-type 1.|RING-type 1; atypical.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						CGTTTGCGGGCAGTCAGAGCA	0.582		NA	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			5	11					0	0	0	0
NCKAP5L	57701	broad.mit.edu	37	12	50186272	50186272	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:50186272A>G	uc009zlk.2	-	12	3951	c.3749T>C	c.(3748-3750)ATG>ACG	p.M1250T	NCKAP5L_uc001rvc.3_Missense_Mutation_p.M454T|NCKAP5L_uc001rvb.2_Missense_Mutation_p.M843T	NM_001037806	NP_001032895	Q9HCH0	NCK5L_HUMAN	NCK-associated protein 5-like	1246	Pro-rich.									central_nervous_system(1)	1						GGGTGGGCACATGAGAGGGTC	0.632		NA											8	27					0	0	0	0
LARP4	113251	broad.mit.edu	37	12	50847384	50847384	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:50847384C>G	uc001rwp.1	+	9	1090	c.946C>G	c.(946-948)CAG>GAG	p.Q316E	LARP4_uc001rwo.1_Missense_Mutation_p.Q322E|LARP4_uc001rwq.1_Intron|LARP4_uc001rwr.1_Missense_Mutation_p.Q316E|LARP4_uc001rws.1_Missense_Mutation_p.Q315E|LARP4_uc009zlr.1_Missense_Mutation_p.Q135E|LARP4_uc001rwt.1_Intron|LARP4_uc001rwm.2_Missense_Mutation_p.Q316E|LARP4_uc001rwn.2_Missense_Mutation_p.Q246E	NM_052879	NP_443111	Q71RC2	LARP4_HUMAN	c-Mpl binding protein isoform a	316							nucleotide binding|RNA binding			ovary(1)	1						TCCTCACCAACAGTACTCGGT	0.393		NA											27	81					0	0	0	0
ATF1	466	broad.mit.edu	37	12	51213453	51213453	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:51213453A>G	uc001rww.3	+	7	985	c.707A>G	c.(706-708)GAA>GGA	p.E236G	ATF1_uc010smu.1_Missense_Mutation_p.E101G	NM_005171	NP_005162	P18846	ATF1_HUMAN	activating transcription factor 1	236					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway				EWSR1/ATF1(323)|FUS/ATF1(4)	soft_tissue(321)|ovary(2)|NS(2)|bone(2)|skin(2)	329						AAGAAGAAAGAATATGTGAAA	0.308		NA	T	EWSR1|FUS	malignant melanoma of soft parts |angiomatoid fibrous histiocytoma 								21	26					0	0	0	0
KRT79	338785	broad.mit.edu	37	12	53227940	53227940	+	Silent	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:53227940T>C	uc001sbb.2	-	1	138	c.105A>G	c.(103-105)TCA>TCG	p.S35S		NM_175834	NP_787028	Q5XKE5	K2C79_HUMAN	keratin 6L	35	Head.					keratin filament	structural molecule activity			ovary(2)|skin(2)	4						ACACCGTCACTGAGCTGAAGC	0.647		NA											18	42					0	0	0	0
KRT78	196374	broad.mit.edu	37	12	53233651	53233651	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:53233651G>T	uc001sbc.1	-	7	1229	c.1165C>A	c.(1165-1167)CTG>ATG	p.L389M		NM_173352	NP_775487	Q8N1N4	K2C78_HUMAN	keratin 5b	389	Coil 2.|Rod.					keratin filament	protein binding|structural molecule activity			ovary(2)	2						AGCCGGGCCAGGTTCTGCTTG	0.637		NA											20	50					7.21e-19	1.45e-18	1	0
KRT18	3875	broad.mit.edu	37	12	53346565	53346565	+	Missense_Mutation	SNP	G	G	A	rs148580152		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:53346565G>A	uc001sbe.2	+	8	1301	c.1232G>A	c.(1231-1233)CGC>CAC	p.R411H	KRT18_uc009zmn.1_3'UTR|KRT18_uc001sbf.1_3'UTR|KRT18_uc001sbg.2_Missense_Mutation_p.R411H|KRT18_uc009zmo.2_3'UTR	NM_199187	NP_954657	P05783	K1C18_HUMAN	keratin 18	411	Tail.				anatomical structure morphogenesis|cell cycle|Golgi to plasma membrane CFTR protein transport|interspecies interaction between organisms|negative regulation of apoptosis	centriolar satellite|keratin filament|perinuclear region of cytoplasm	protein binding|structural molecule activity			skin(1)	1						ACCACCACCCGCCGGATAGTG	0.532		NA											24	48					0	0	0	0
IKZF4	64375	broad.mit.edu	37	12	56429106	56429106	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:56429106G>A	uc001sjb.1	+	9	1908	c.1749G>A	c.(1747-1749)AAG>AAA	p.K583K	IKZF4_uc010sqa.1_Silent_p.K536K|IKZF4_uc001sjc.1_Silent_p.K583K|IKZF4_uc001sjd.1_Silent_p.K481K|IKZF4_uc009zoi.1_Silent_p.K538K|IKZF4_uc001sje.1_Silent_p.K542K	NM_022465	NP_071910	Q9H2S9	IKZF4_HUMAN	zinc finger protein, subfamily 1A, 4	583					negative regulation of transcription, DNA-dependent	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1			UCEC - Uterine corpus endometrioid carcinoma (6;0.025)|OV - Ovarian serous cystadenocarcinoma(18;0.123)			GGGAGCATAAGGTGGGCTAGC	0.547		NA											7	191					0	0	0	0
INHBC	3626	broad.mit.edu	37	12	57843137	57843137	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:57843137C>G	uc001snv.1	+	2	518	c.391C>G	c.(391-393)CAG>GAG	p.Q131E		NM_005538	NP_005529	P55103	INHBC_HUMAN	inhibin beta C chain preproprotein	131					growth	extracellular region	growth factor activity|hormone activity|transforming growth factor beta receptor binding				0						GGAGGTCCAGCAGGCCAGTCT	0.507		NA											65	181					0	0	0	0
METTL1	4234	broad.mit.edu	37	12	58163103	58163103	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:58163103C>A	uc010ssd.1	-	5	706	c.658G>T	c.(658-660)GTG>TTG	p.V220L	CYP27B1_uc001spz.1_5'Flank|CYP27B1_uc001sqa.1_5'Flank|METTL1_uc009zqc.2_3'UTR	NM_005371	NP_005362	Q9UBP6	TRMB_HUMAN	methyltransferase-like protein 1 isoform a	220						cytoplasm|nucleus	protein binding|tRNA (guanine-N7-)-methyltransferase activity|tRNA binding				0	all_cancers(7;6.73e-81)|Lung NSC(6;1.07e-25)|all_lung(6;8.25e-24)|all_epithelial(6;4.6e-17)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.211)			TCCAGAGGCACACGCTCAAAC	0.537		NA											11	21					3.86e-05	6e-05	1	0
SLC16A7	9194	broad.mit.edu	37	12	60173400	60173400	+	Silent	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:60173400T>C	uc001sqs.2	+	6	1676	c.1377T>C	c.(1375-1377)GAT>GAC	p.D459D	SLC16A7_uc001sqt.2_Silent_p.D459D|SLC16A7_uc001squ.2_Silent_p.D459D|SLC16A7_uc009zqi.2_Silent_p.D360D|SLC16A7_uc010ssi.1_Silent_p.D360D	NM_004731	NP_004722	O60669	MOT2_HUMAN	solute carrier family 16, member 7	459	Cytoplasmic (Potential).					integral to plasma membrane|membrane fraction	pyruvate secondary active transmembrane transporter activity|secondary active monocarboxylate transmembrane transporter activity|symporter activity			ovary(1)	1				GBM - Glioblastoma multiforme(3;0.0303)	Pyruvic acid(DB00119)	ATTCGGAAGATGTTAACGTCA	0.368		NA											7	19					0	0	0	0
USP15	9958	broad.mit.edu	37	12	62715352	62715352	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:62715352G>T	uc001src.1	+	5	592	c.583G>T	c.(583-585)GAC>TAC	p.D195Y	USP15_uc001srb.1_Missense_Mutation_p.D195Y|USP15_uc001sra.2_Missense_Mutation_p.D195Y	NM_006313	NP_006304	Q9Y4E8	UBP15_HUMAN	ubiquitin specific peptidase 15	195					protein deubiquitination|ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|lung(1)	3			GBM - Glioblastoma multiforme(1;0.000276)	GBM - Glioblastoma multiforme(28;0.0622)		GAATAAACCAGACAGCACCAT	0.333		NA											7	29					0.000274275	0.000411185	1	0
AVPR1A	552	broad.mit.edu	37	12	63543951	63543951	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:63543951G>T	uc001sro.1	-	1	2640	c.666C>A	c.(664-666)GGC>GGA	p.G222G		NM_000706	NP_000697	P37288	V1AR_HUMAN	arginine vasopressin receptor 1A	222	Helical; Name=5; (Potential).				activation of phospholipase C activity|elevation of cytosolic calcium ion concentration|generation of precursor metabolites and energy	endosome|integral to plasma membrane	protein kinase C binding|vasopressin receptor activity				0			BRCA - Breast invasive adenocarcinoma(9;0.193)	GBM - Glioblastoma multiforme(28;0.0569)	Conivaptan(DB00872)|Desmopressin(DB00035)|Felypressin(DB00093)|Terlipressin(DB02638)|Vasopressin(DB00067)	CAAAGATGCCGCCCGTCATCC	0.612		NA											34	93					3.9e-15	7.56e-15	1	0
TMBIM4	51643	broad.mit.edu	37	12	66531826	66531826	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:66531826C>T	uc001stc.2	-	7	707	c.631G>A	c.(631-633)GTA>ATA	p.V211I	LLPH_uc010ssx.1_RNA|TMBIM4_uc001std.2_Missense_Mutation_p.V180I|TMBIM4_uc009zqr.2_Missense_Mutation_p.V258I|TMBIM4_uc001ste.2_RNA|TMBIM4_uc001stf.2_3'UTR|TMBIM4_uc009zqs.2_3'UTR	NM_016056	NP_057140	Q9HC24	TMBI4_HUMAN	transmembrane BAX inhibitor motif containing 4	211	Helical; (Potential).					integral to membrane	protein binding			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(28;0.0745)		GCAGCTAATACGTACTCTTCA	0.413		NA											22	47					0	0	0	0
DYRK2	8445	broad.mit.edu	37	12	68051900	68051900	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:68051900A>T	uc001str.3	+	3	1615	c.1213A>T	c.(1213-1215)ATG>TTG	p.M405L	DYRK2_uc001sts.3_Missense_Mutation_p.M332L	NM_006482	NP_006473	Q92630	DYRK2_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	405	Protein kinase.				apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|positive regulation of glycogen biosynthetic process|smoothened signaling pathway	cytoplasm|nucleus	ATP binding|magnesium ion binding|manganese ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(2)|breast(1)|central_nervous_system(1)	4			Lung(24;6.81e-05)|LUAD - Lung adenocarcinoma(15;0.00107)|LUSC - Lung squamous cell carcinoma(43;0.196)	GBM - Glioblastoma multiforme(7;0.000573)		GCCCATTGATATGTGGAGCCT	0.542		NA											11	30					0	0	0	0
MDM2	4193	broad.mit.edu	37	12	69203025	69203025	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:69203025G>C	uc001sui.2	+	2	339	c.52G>C	c.(52-54)GGT>CGT	p.G18R	MDM2_uc009zri.2_Missense_Mutation_p.G18R|MDM2_uc009zqx.2_Missense_Mutation_p.G18R|MDM2_uc009zqw.2_Missense_Mutation_p.G18R|MDM2_uc001suk.2_Missense_Mutation_p.G18R|MDM2_uc009zqy.1_Missense_Mutation_p.G7R|MDM2_uc001sun.3_Missense_Mutation_p.G7R|MDM2_uc009zqz.2_Missense_Mutation_p.G12R|MDM2_uc009zra.2_Missense_Mutation_p.G12R|MDM2_uc009zrb.1_RNA|MDM2_uc001sum.1_Missense_Mutation_p.G7R|MDM2_uc009zrd.2_5'UTR|MDM2_uc009zrc.2_5'UTR|MDM2_uc009zre.2_Missense_Mutation_p.G7R|MDM2_uc009zrf.2_5'UTR|MDM2_uc001suo.2_Missense_Mutation_p.G7R|MDM2_uc009zrg.2_Missense_Mutation_p.G7R|MDM2_uc009zrh.2_Missense_Mutation_p.G7R	NM_002392	NP_002383	Q00987	MDM2_HUMAN	mouse double minute 2 homolog isoform MDM2	12	Necessary for interaction with USP2.				cellular response to hypoxia|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|establishment of protein localization|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell cycle arrest|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell proliferation|positive regulation of mitotic cell cycle|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein complex assembly|protein destabilization|protein localization to nucleus|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to antibiotic|synaptic transmission	cytosol|endocytic vesicle membrane|insoluble fraction|nucleolus|nucleoplasm|plasma membrane|protein complex	enzyme binding|identical protein binding|p53 binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)|central_nervous_system(1)	3	all_cancers(1;8.46e-121)|all_epithelial(5;3.21e-36)|Lung NSC(4;2.16e-33)|all_lung(4;3.03e-31)|Glioma(1;1.9e-09)|Breast(13;1.59e-06)|all_neural(1;1.03e-05)|Melanoma(1;0.0171)|Renal(347;0.0684)		all cancers(2;8.67e-65)|GBM - Glioblastoma multiforme(2;8.89e-62)|BRCA - Breast invasive adenocarcinoma(5;2.43e-08)|Lung(24;1.5e-05)|LUAD - Lung adenocarcinoma(15;8.5e-05)|STAD - Stomach adenocarcinoma(21;0.00372)|Kidney(9;0.143)			ACCTACTGATGGTGCTGTAAC	0.368		NA	A		sarcoma|glioma|colorectal|other								134	285					0	0	0	0
PTPRR	5801	broad.mit.edu	37	12	71078504	71078504	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:71078504T>C	uc001swi.1	-	9	1755	c.1339A>G	c.(1339-1341)ATT>GTT	p.I447V	PTPRR_uc001swh.1_Missense_Mutation_p.I202V|PTPRR_uc009zrs.2_Missense_Mutation_p.I296V|PTPRR_uc010stq.1_Missense_Mutation_p.I335V|PTPRR_uc010str.1_Missense_Mutation_p.I296V	NM_002849	NP_002840	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R	447	Tyrosine-protein phosphatase.|Cytoplasmic (Potential).				in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			skin(2)|ovary(1)	3			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		TTAGCATTAATGTAGGTGCTC	0.299		NA											24	59					0	0	0	0
CAPS2	84698	broad.mit.edu	37	12	75687068	75687068	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:75687068C>A	uc001sxk.3	-	13	1378	c.1181G>T	c.(1180-1182)CGA>CTA	p.R394L	CAPS2_uc001sxm.3_Missense_Mutation_p.R162L|CAPS2_uc009zsa.2_5'UTR|CAPS2_uc001sxi.3_Missense_Mutation_p.R130L|CAPS2_uc001sxj.3_Missense_Mutation_p.R305L|CAPS2_uc001sxl.3_Missense_Mutation_p.R375L	NM_032606	NP_115995	Q9BXY5	CAYP2_HUMAN	calcyphosine 2	394							calcium ion binding			ovary(2)	2						ATTTGTGATTCGGAGTTTAAG	0.318		NA											19	52					5.39e-06	8.68e-06	1	0
NAV3	89795	broad.mit.edu	37	12	78400500	78400500	+	Silent	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:78400500G>C	uc001syp.2	+	8	1355	c.1182G>C	c.(1180-1182)CGG>CGC	p.R394R	NAV3_uc001syo.2_Silent_p.R394R	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	394						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						TCAATGCCCGGACTGCTTTAC	0.498		NA								HNSCC(70;0.22)			25	69					0	0	0	0
ACSS3	79611	broad.mit.edu	37	12	81627154	81627154	+	Silent	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:81627154T>C	uc001szl.1	+	13	1714	c.1623T>C	c.(1621-1623)GGT>GGC	p.G541G	ACSS3_uc001szm.1_Silent_p.G540G|ACSS3_uc001szn.1_Silent_p.G223G	NM_024560	NP_078836	Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	541						mitochondrion	acetate-CoA ligase activity|ATP binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4						TGGATGCTGGTTACATGGATG	0.343		NA											31	99					0	0	0	0
SLC6A15	55117	broad.mit.edu	37	12	85255711	85255711	+	Silent	SNP	G	G	T	rs149254147		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:85255711G>T	uc001szv.2	-	12	2386	c.1893C>A	c.(1891-1893)CTC>CTA	p.L631L	SLC6A15_uc010sul.1_Silent_p.L524L|SLC6A15_uc001szw.1_Intron	NM_182767	NP_877499	Q9H2J7	S6A15_HUMAN	solute carrier family 6, member 15 isoform 1	631	Helical; Name=12; (Potential).				cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			pancreas(2)|ovary(1)	3						CAGGGACTGGGAGTATTGCAA	0.393		NA											19	88					3.57e-18	7.14e-18	1	0
SLC6A15	55117	broad.mit.edu	37	12	85266419	85266419	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:85266419G>A	uc001szv.2	-	8	1757	c.1264C>T	c.(1264-1266)CAT>TAT	p.H422Y	SLC6A15_uc010sul.1_Missense_Mutation_p.H315Y|SLC6A15_uc001szw.1_Missense_Mutation_p.H130Y	NM_182767	NP_877499	Q9H2J7	S6A15_HUMAN	solute carrier family 6, member 15 isoform 1	422	Extracellular (Potential).				cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			pancreas(2)|ovary(1)	3						GAATTGAGATGAAGAGCAGGA	0.308		NA											20	36					0	0	0	0
C12orf29	91298	broad.mit.edu	37	12	88433979	88433979	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:88433979A>T	uc001tao.2	+	2	303	c.145A>T	c.(145-147)ATA>TTA	p.I49L	C12orf29_uc001tap.2_Intron|C12orf29_uc009zsk.2_Intron	NM_001009894	NP_001009894	Q8N999	CL029_HUMAN	hypothetical protein LOC91298	49											0						AGATGCAGATATATACAGTGC	0.308		NA											23	42					0	0	0	0
CCDC38	120935	broad.mit.edu	37	12	96312654	96312654	+	Silent	SNP	C	C	A	rs139084164		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:96312654C>A	uc001tek.1	-	3	372	c.138G>T	c.(136-138)ACG>ACT	p.T46T		NM_182496	NP_872302	Q502W7	CCD38_HUMAN	coiled-coil domain containing 38	46										skin(1)	1						TAAACTTTACCGTTTCCTTTG	0.363		NA											14	46					1.15e-07	1.93e-07	1	0
C12orf63	374467	broad.mit.edu	37	12	97158856	97158856	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:97158856T>C	uc001tet.1	+	27	3494	c.3416T>C	c.(3415-3417)GTC>GCC	p.V1139A		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	1139										skin(6)|ovary(1)	7						TAATTGTAGGTCAGTGAAGCT	0.274		NA											15	57					0	0	0	0
IKBIP	121457	broad.mit.edu	37	12	99007656	99007656	+	Missense_Mutation	SNP	C	C	A	rs147943089	by1000genomes	TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:99007656C>A	uc001tfv.2	-	3	870	c.760G>T	c.(760-762)GAC>TAC	p.D254Y	IKBIP_uc001tfw.2_3'UTR	NM_201612	NP_963906	Q70UQ0	IKIP_HUMAN	IKK interacting protein isoform 2	254					induction of apoptosis|response to X-ray	endoplasmic reticulum membrane|integral to membrane	protein binding				0						GTATGTTTGTCGAAGTCACTC	0.378		NA											20	68					2.46e-09	4.32e-09	1	0
NR1H4	9971	broad.mit.edu	37	12	100928694	100928694	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:100928694T>C	uc001tht.1	+	4	683	c.655T>C	c.(655-657)TCT>CCT	p.S219P	NR1H4_uc001thp.1_Missense_Mutation_p.S205P|NR1H4_uc001thq.1_Missense_Mutation_p.S209P|NR1H4_uc010svj.1_RNA|NR1H4_uc001thr.1_Missense_Mutation_p.S209P|NR1H4_uc010svk.1_Missense_Mutation_p.S158P|NR1H4_uc001ths.1_Missense_Mutation_p.S215P	NM_005123	NP_005114	Q96RI1	NR1H4_HUMAN	nuclear receptor subfamily 1, group H, member 4	219					bile acid metabolic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)|lung(1)|skin(1)	3						TCAGTGTAAATCTAAGCGACT	0.413		NA											16	21					0	0	0	0
ANO4	121601	broad.mit.edu	37	12	101491468	101491468	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:101491468C>A	uc010svm.1	+	20	2462	c.1890C>A	c.(1888-1890)AAC>AAA	p.N630K	ANO4_uc001thw.2_Missense_Mutation_p.N595K|ANO4_uc001thx.2_Missense_Mutation_p.N630K|ANO4_uc001thy.2_Missense_Mutation_p.N150K	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4	630	Cytoplasmic (Potential).					chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6						GGCTGATAAACAGGTGGAGAC	0.428		NA								HNSCC(74;0.22)			20	52					2.4e-15	4.64e-15	1	0
SLC5A8	160728	broad.mit.edu	37	12	101603614	101603614	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:101603614G>T	uc001thz.3	-	1	403	c.13C>A	c.(13-15)CGG>AGG	p.R5R		NM_145913	NP_666018	Q8N695	SC5A8_HUMAN	solute carrier family 5 (iodide transporter),	5	Extracellular (Potential).				apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity				0						CCGATGCCCCGTGGCGTGTCC	0.706		NA											7	13					0.000157383	0.000239122	1	0
APPL2	55198	broad.mit.edu	37	12	105600962	105600962	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:105600962C>G	uc001tlf.1	-	8	716	c.498G>C	c.(496-498)GAG>GAC	p.E166D	APPL2_uc010swt.1_Missense_Mutation_p.E123D|APPL2_uc001tlg.1_5'UTR|APPL2_uc010swu.1_Missense_Mutation_p.E172D|APPL2_uc009zuq.2_Missense_Mutation_p.E123D	NM_018171	NP_060641	Q8NEU8	DP13B_HUMAN	adaptor protein, phosphotyrosine interaction, PH	166	Required for RAB5A binding (By similarity).				cell cycle|cell proliferation|signal transduction	early endosome membrane|nucleus	protein binding			upper_aerodigestive_tract(1)	1						CCGCGGCCACCTCTTTTCCGA	0.512		NA											14	35					0	0	0	0
NUAK1	9891	broad.mit.edu	37	12	106466568	106466568	+	Silent	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:106466568C>G	uc001tlj.1	-	5	2013	c.633G>C	c.(631-633)ACG>ACC	p.T211T		NM_014840	NP_055655	O60285	NUAK1_HUMAN	AMPK-related protein kinase 5	211	Protein kinase.			T->A: Prevents phosphorylation and activation by STK11/LKB1 complex.			ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(1)|central_nervous_system(1)	2						TCCCACAAAACGTTTGTAAGA	0.488		NA											21	50					0	0	0	0
BTBD11	121551	broad.mit.edu	37	12	108029160	108029160	+	Silent	SNP	G	G	C	rs149726114	byFrequency	TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:108029160G>C	uc001tmk.1	+	12	3251	c.2730G>C	c.(2728-2730)TCG>TCC	p.S910S	BTBD11_uc009zut.1_Silent_p.S791S|BTBD11_uc001tmj.2_Silent_p.S910S|BTBD11_uc001tml.1_Silent_p.S447S|BTBD11_uc001tmm.1_5'UTR	NM_001018072	NP_001018082	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11 isoform a	910						integral to membrane	DNA binding			skin(2)|ovary(1)	3						AACAGACCTCGCGCTTGGGTG	0.552		NA											22	49					0	0	0	0
SART3	9733	broad.mit.edu	37	12	108930562	108930562	+	Splice_Site	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:108930562C>A	uc001tmz.1	-	10	1545	c.1310_splice	c.e10-1	p.D437_splice	SART3_uc001tmy.1_Splice_Site|SART3_uc009zux.1_Splice_Site_p.D49_splice|SART3_uc010swx.1_Splice_Site_p.D401_splice|SART3_uc010swy.1_Splice_Site_p.D323_splice|SART3_uc010swz.1_Splice_Site_p.D437_splice|SART3_uc001tna.1_Splice_Site	NM_014706	NP_055521	Q15020	SART3_HUMAN	squamous cell carcinoma antigen recognized by T						RNA processing	cytoplasm|nuclear speck	nucleotide binding|protein binding|RNA binding			pancreas(1)	1						TTACTGGAGTCTAACGGAAAG	0.448		NA							Porokeratosis				12	22					2.81e-09	4.9e-09	1	0
ALKBH2	121642	broad.mit.edu	37	12	109530453	109530453	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:109530453C>A	uc001tnx.2	-	2	532	c.139G>T	c.(139-141)GGG>TGG	p.G47W	ALKBH2_uc001tny.2_Missense_Mutation_p.G47W|ALKBH2_uc010sxj.1_Missense_Mutation_p.G47W|ALKBH2_uc009zvd.2_Missense_Mutation_p.G47W|ALKBH2_uc010sxk.1_Missense_Mutation_p.G47W	NM_001145374	NP_001138846	Q6NS38	ALKB2_HUMAN	AlkB homolog 2	47					DNA dealkylation involved in DNA repair|oxidative DNA demethylation	nucleoplasm	cytosine C-5 DNA demethylase activity|damaged DNA binding|DNA-N1-methyladenine dioxygenase activity|ferrous iron binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0					Vitamin C(DB00126)	CCTCCATTCCCTGGGGCCTCT	0.582		NA						Direct_reversal_of_damage					50	115					1.01e-21	2.06e-21	1	0
ACACB	32	broad.mit.edu	37	12	109650676	109650676	+	Silent	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:109650676G>C	uc001tob.2	+	22	3404	c.3285G>C	c.(3283-3285)CTG>CTC	p.L1095L	ACACB_uc001toc.2_Silent_p.L1095L	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	1095					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	CAGCCACCCTGCAGCGGAAGG	0.542		NA											45	114					0	0	0	0
UBE3B	89910	broad.mit.edu	37	12	109959106	109959106	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:109959106G>C	uc001top.2	+	20	2833	c.2230G>C	c.(2230-2232)GAC>CAC	p.D744H	UBE3B_uc001toq.2_Missense_Mutation_p.D744H|UBE3B_uc001tos.2_Missense_Mutation_p.D171H|UBE3B_uc001too.1_RNA|UBE3B_uc009zvj.1_Missense_Mutation_p.D744H	NM_130466	NP_569733	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	744	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			ovary(2)|lung(2)	4						GAGAGTTTTTGACCCAGCACT	0.488		NA											31	99					0	0	0	0
C12orf51	283450	broad.mit.edu	37	12	112670875	112670875	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:112670875C>G	uc009zwc.2	-	31	4682	c.4664G>C	c.(4663-4665)CGG>CCG	p.R1555P		NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						TCGGAAGGGCCGTCCTTCTGA	0.512		NA											5	7					0	0	0	0
RPH3A	22895	broad.mit.edu	37	12	113307719	113307719	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:113307719C>A	uc010syl.1	+	10	1033	c.671C>A	c.(670-672)CCC>CAC	p.P224H	RPH3A_uc001ttz.2_Missense_Mutation_p.P224H|RPH3A_uc001tty.2_Missense_Mutation_p.P220H|RPH3A_uc009zwe.1_Missense_Mutation_p.P220H|RPH3A_uc010sym.1_Missense_Mutation_p.P175H|RPH3A_uc001tua.2_5'UTR	NM_001143854	NP_001137326	Q9Y2J0	RP3A_HUMAN	rabphilin 3A homolog isoform 1	224	Pro-rich.				intracellular protein transport	cell junction|synaptic vesicle	Rab GTPase binding|transporter activity|zinc ion binding			ovary(3)|central_nervous_system(2)|skin(2)	7				BRCA - Breast invasive adenocarcinoma(302;0.00453)		GCCTCTGCTCCCGGGCGAGGA	0.562		NA											29	62					3.99e-17	7.9e-17	1	0
RPH3A	22895	broad.mit.edu	37	12	113321158	113321158	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:113321158C>T	uc010syl.1	+	16	1749	c.1387C>T	c.(1387-1389)CTC>TTC	p.L463F	RPH3A_uc001ttz.2_Missense_Mutation_p.L463F|RPH3A_uc001tty.2_Missense_Mutation_p.L459F|RPH3A_uc009zwe.1_Missense_Mutation_p.L459F|RPH3A_uc010sym.1_Missense_Mutation_p.L414F|RPH3A_uc001tua.2_Missense_Mutation_p.L223F	NM_001143854	NP_001137326	Q9Y2J0	RP3A_HUMAN	rabphilin 3A homolog isoform 1	463	C2 1.				intracellular protein transport	cell junction|synaptic vesicle	Rab GTPase binding|transporter activity|zinc ion binding			ovary(3)|central_nervous_system(2)|skin(2)	7				BRCA - Breast invasive adenocarcinoma(302;0.00453)		GAATGAGACCCTCGTGTATCA	0.562		NA											10	23					0	0	0	0
PRKAB1	5564	broad.mit.edu	37	12	120114377	120114377	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:120114377G>T	uc009zwu.2	+	6	671	c.568G>T	c.(568-570)GAG>TAG	p.E190*	PRKAB1_uc001txg.2_Nonsense_Mutation_p.E190*	NM_006253	NP_006244	Q9Y478	AAKB1_HUMAN	AMP-activated protein kinase beta 1	190					cell cycle arrest|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid oxidation	cytosol					0	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.166)	Adenosine monophosphate(DB00131)|Metformin(DB00331)	CTACCATCAGGAGCCCTACGT	0.537		NA											36	80					9.81e-26	2.05e-25	1	0
CLIP1	6249	broad.mit.edu	37	12	122825411	122825411	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:122825411C>T	uc001ucg.1	-	10	2446	c.2340G>A	c.(2338-2340)CGG>CGA	p.R780R	CLIP1_uc001uch.1_Silent_p.R769R|CLIP1_uc001uci.1_Silent_p.R734R|CLIP1_uc001ucj.1_Intron	NM_002956	NP_002947	P30622	CLIP1_HUMAN	restin isoform a	780	Potential.				mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			ovary(2)|breast(1)	3	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		AACTGGCTTTCCGAAGTGCAT	0.393		NA											45	99					0	0	0	0
SBNO1	55206	broad.mit.edu	37	12	123780568	123780568	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:123780568G>A	uc010tap.1	-	31	4069	c.4069C>T	c.(4069-4071)CCT>TCT	p.P1357S	SBNO1_uc009zxv.2_RNA|SBNO1_uc010tao.1_Missense_Mutation_p.P1356S|SBNO1_uc010taq.1_Missense_Mutation_p.P308S	NM_018183	NP_060653	A3KN83	SBNO1_HUMAN	sno, strawberry notch homolog 1	1357							ATP binding|DNA binding|hydrolase activity			breast(5)|skin(2)|ovary(1)|kidney(1)	9	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		TTTACAAGAGGAGACACACAA	0.428		NA											46	104					0	0	0	0
DNAH10	196385	broad.mit.edu	37	12	124383262	124383262	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:124383262G>T	uc001uft.3	+	55	9212	c.9187G>T	c.(9187-9189)GAG>TAG	p.E3063*		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	3063	Potential.|Stalk (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		CCAGCTGGACGAGCTGAACCA	0.617		NA											3	12					6.4e-05	9.89e-05	1	0
TMEM132D	121256	broad.mit.edu	37	12	130184929	130184929	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:130184929G>T	uc009zyl.1	-	2	722	c.394C>A	c.(394-396)CAC>AAC	p.H132N		NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	132	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		CGCAGGATGTGGGCTTTTAGT	0.527		NA											14	30					1.36e-06	2.23e-06	1	0
PIWIL1	9271	broad.mit.edu	37	12	130831562	130831562	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:130831562C>A	uc001uik.2	+	6	698	c.608C>A	c.(607-609)CCT>CAT	p.P203H	PIWIL1_uc001uij.1_Missense_Mutation_p.P203H	NM_004764	NP_004755	Q96J94	PIWL1_HUMAN	piwi-like 1	203					gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		GAACTTCCACCTACATCACCA	0.303		NA											17	36					6.94e-10	1.24e-09	1	0
GPR133	283383	broad.mit.edu	37	12	131466553	131466553	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:131466553G>A	uc001uit.3	+	5	994	c.435G>A	c.(433-435)GTG>GTA	p.V145V	GPR133_uc010tbm.1_Silent_p.V177V	NM_198827	NP_942122	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133 precursor	145	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(5)|ovary(3)|skin(2)	10	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		GAGGCTCTGTGGAGCTGTATA	0.587		NA											38	71					0	0	0	0
POLE	5426	broad.mit.edu	37	12	133225973	133225973	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:133225973C>A	uc001uks.1	-	31	3968	c.3924G>T	c.(3922-3924)CGG>CGT	p.R1308R	POLE_uc001ukr.1_Silent_p.R112R|POLE_uc010tbq.1_RNA|POLE_uc009zyu.1_Silent_p.R1281R	NM_006231	NP_006222	Q07864	DPOE1_HUMAN	DNA-directed DNA polymerase epsilon	1308					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		CAGGACCATCCCGGATGGCCC	0.647		NA						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					17	50					9.17e-09	1.59e-08	1	0
POLE	5426	broad.mit.edu	37	12	133234500	133234500	+	Missense_Mutation	SNP	C	C	T	rs114315196	by1000genomes	TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:133234500C>T	uc001uks.1	-	27	3376	c.3332G>A	c.(3331-3333)CGG>CAG	p.R1111Q	POLE_uc001ukr.1_5'UTR|POLE_uc010tbq.1_RNA|POLE_uc009zyu.1_Missense_Mutation_p.R1084Q	NM_006231	NP_006222	Q07864	DPOE1_HUMAN	DNA-directed DNA polymerase epsilon	1111					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		GAGCCATTTCCGGAGAAAGTG	0.483		NA						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					34	84					0	0	0	0
POLE	5426	broad.mit.edu	37	12	133257867	133257867	+	Splice_Site	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:133257867T>A	uc001uks.1	-	2	107	c.63_splice	c.e2-1	p.R21_splice	POLE_uc010tbq.1_Splice_Site|POLE_uc009zyu.1_Splice_Site_p.R21_splice	NM_006231	NP_006222	Q07864	DPOE1_HUMAN	DNA-directed DNA polymerase epsilon						base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		CCATCATCCCTGAGTGAAAGA	0.403		NA						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					35	82					0	0	0	0
ZNF10	7556	broad.mit.edu	37	12	133732562	133732562	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:133732562G>A	uc009zzb.2	+	5	1177	c.730G>A	c.(730-732)GAC>AAC	p.D244N	ZNF268_uc010tbv.1_Intron|ZNF10_uc001ulq.2_Missense_Mutation_p.D244N	NM_015394	NP_056209	P21506	ZNF10_HUMAN	zinc finger protein 10	244				Missing (in Ref. 1).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|skin(1)	3	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;1.28e-06)|all_epithelial(31;0.0051)|Lung NSC(355;0.00948)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		CCCTGATAATGACAACTCTCT	0.378		NA											12	27					0	0	0	0
ZNF10	7556	broad.mit.edu	37	12	133733348	133733348	+	Nonsense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:133733348A>T	uc009zzb.2	+	5	1963	c.1516A>T	c.(1516-1518)AAG>TAG	p.K506*	ZNF268_uc010tbv.1_Intron|ZNF10_uc001ulq.2_Nonsense_Mutation_p.K506*	NM_015394	NP_056209	P21506	ZNF10_HUMAN	zinc finger protein 10	506	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|skin(1)	3	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;1.28e-06)|all_epithelial(31;0.0051)|Lung NSC(355;0.00948)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		TGACCTCATTAAGCACCAGAG	0.413		NA											13	42					0	0	0	0
TUBA3C	7278	broad.mit.edu	37	13	19753636	19753636	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr13:19753636T>A	uc009zzj.2	-	2	120	c.71A>T	c.(70-72)TAC>TTC	p.Y24F		NM_006001	NP_005992	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	24					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(3)|skin(2)	5		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		TTCCAGGCAGTACAGTTCCCA	0.512		NA											50	45					0	0	0	0
RNF17	56163	broad.mit.edu	37	13	25406105	25406105	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr13:25406105G>T	uc001upr.2	+	18	2512	c.2471G>T	c.(2470-2472)TGT>TTT	p.C824F	RNF17_uc010tdd.1_Missense_Mutation_p.C683F|RNF17_uc010aab.2_RNA|RNF17_uc010tde.1_Missense_Mutation_p.C824F|RNF17_uc001ups.2_Missense_Mutation_p.C763F|RNF17_uc010aac.2_Missense_Mutation_p.C22F	NM_031277	NP_112567	Q9BXT8	RNF17_HUMAN	ring finger protein 17	824					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		TTTATGACATGTTCAGTTATC	0.259		NA											6	12					0.00116845	0.00172167	1	0
PABPC3	5042	broad.mit.edu	37	13	25671150	25671150	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr13:25671150C>A	uc001upy.2	+	1	875	c.814C>A	c.(814-816)CGG>AGG	p.R272R		NM_030979	NP_112241	Q9H361	PABP3_HUMAN	poly(A) binding protein, cytoplasmic 3	272					mRNA metabolic process	cytoplasm	nucleotide binding|poly(A) RNA binding			ovary(3)|skin(1)	4		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		AAAAGTGGAACGGCAGACGGA	0.398		NA											30	37					7.26e-15	1.4e-14	1	0
ATP8A2	51761	broad.mit.edu	37	13	26343303	26343303	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr13:26343303G>T	uc001uqk.2	+	26	2646	c.2504G>T	c.(2503-2505)GGT>GTT	p.G835V	ATP8A2_uc010tdi.1_Missense_Mutation_p.G795V|ATP8A2_uc010tdj.1_RNA|ATP8A2_uc010aaj.1_Missense_Mutation_p.G385V	NM_016529	NP_057613	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter-like,	795	Cytoplasmic (Potential).				ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|large_intestine(1)|skin(1)	4		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		GCCCACGTGGGTGTGGGAATC	0.592		NA											20	52					3.6e-14	6.85e-14	1	0
FLT3	2322	broad.mit.edu	37	13	28592684	28592684	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr13:28592684G>C	uc001urw.2	-	20	2543	c.2461C>G	c.(2461-2463)CAC>GAC	p.H821D	FLT3_uc010aao.2_RNA|FLT3_uc010tdn.1_Intron	NM_004119	NP_004110	P36888	FLT3_HUMAN	fms-related tyrosine kinase 3 precursor	821	Protein kinase.|Cytoplasmic (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity			haematopoietic_and_lymphoid_tissue(8536)|lung(7)|ovary(3)|stomach(1)|central_nervous_system(1)|skin(1)	8549	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	ACTTTCCCGTGGGTGACAAGC	0.468		NA	Mis|O		AML|ALL								19	32					0	0	0	0
FREM2	341640	broad.mit.edu	37	13	39264040	39264040	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr13:39264040C>A	uc001uwv.2	+	1	2868	c.2559C>A	c.(2557-2559)CAC>CAA	p.H853Q		NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	853	CSPG 5.|Extracellular (Potential).				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		CAGAGTTGCACGTGAATGATG	0.502		NA											13	28					5.51e-06	8.83e-06	1	0
CYSLTR2	57105	broad.mit.edu	37	13	49281445	49281445	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr13:49281445C>A	uc010acx.1	+	6	1175	c.492C>A	c.(490-492)ATC>ATA	p.I164I	CYSLTR2_uc010acy.1_Silent_p.I164I|CYSLTR2_uc010acz.1_Silent_p.I164I|CYSLTR2_uc010ada.1_Silent_p.I164I|CYSLTR2_uc010adb.1_Silent_p.I164I|CYSLTR2_uc010adc.1_Silent_p.I164I|CYSLTR2_uc010add.1_Silent_p.I164I|CYSLTR2_uc010acw.1_Silent_p.I164I|CYSLTR2_uc001vck.2_Silent_p.I164I	NM_020377	NP_065110	Q9NS75	CLTR2_HUMAN	cysteinyl leukotriene receptor 2	164	Helical; Name=4; (Potential).				immune response	integral to membrane|plasma membrane				lung(2)	2		all_cancers(8;1.66e-53)|all_epithelial(8;1.96e-19)|all_lung(13;9.94e-09)|all_hematologic(8;7.13e-07)|Lung NSC(96;1.72e-06)|Breast(56;1.53e-05)|Acute lymphoblastic leukemia(8;6.86e-05)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0416)|Lung SC(185;0.0787)		GBM - Glioblastoma multiforme(99;1.19e-09)	Nedocromil(DB00716)	TCATATGGATCCTTATCATGG	0.493		NA											53	65					5.14e-22	1.05e-21	1	0
NEK5	341676	broad.mit.edu	37	13	52676308	52676308	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr13:52676308G>A	uc001vge.2	-	10	870	c.730C>T	c.(730-732)CCT>TCT	p.P244S	NEK5_uc001vgf.2_Missense_Mutation_p.P244S	NM_199289	NP_954983	Q6P3R8	NEK5_HUMAN	NIMA-related kinase 5	244	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			upper_aerodigestive_tract(1)	1		Breast(56;0.00173)|Lung NSC(96;0.0168)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;3.7e-08)		CGGTCTCGAGGAGATACTTGA	0.423		NA											5	149					0	0	0	0
PCDH17	27253	broad.mit.edu	37	13	58208274	58208274	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr13:58208274G>T	uc001vhq.1	+	1	2486	c.1594G>T	c.(1594-1596)GGG>TGG	p.G532W	PCDH17_uc010aec.1_Missense_Mutation_p.G532W	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	532	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		TCCCACGAACGGGGCCATCTA	0.587		NA											13	17					0.000151284	0.00023073	1	0
PCDH17	27253	broad.mit.edu	37	13	58208540	58208540	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr13:58208540C>A	uc001vhq.1	+	1	2752	c.1860C>A	c.(1858-1860)AGC>AGA	p.S620R	PCDH17_uc010aec.1_Missense_Mutation_p.S620R	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	620	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		TCGGCGAGAGCGGGCGTCTCA	0.662		NA											28	34					1.77e-15	3.45e-15	1	0
UGGT2	55757	broad.mit.edu	37	13	96599374	96599374	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr13:96599374C>T	uc001vmt.2	-	15	1764	c.1594G>A	c.(1594-1596)GAT>AAT	p.D532N		NM_020121	NP_064506	Q9NYU1	UGGG2_HUMAN	UDP-glucose ceramide glucosyltransferase-like 2	532					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity			ovary(2)|central_nervous_system(1)	3						ACTCCAGCATCATTTGCTCCA	0.343		NA											23	33					0	0	0	0
FAM155A	728215	broad.mit.edu	37	13	108518792	108518793	+	Missense_Mutation	DNP	CA	CA	AG			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr13:108518792_108518793CA>AG	uc001vql.2	-	1	668_669	c.152_153TG>CT	c.(151-153)CTG>CCT	p.L51P		NM_001080396	NP_001073865	B1AL88	F155A_HUMAN	family with sequence similarity 155, member A	51	Helical; (Potential).					integral to membrane	binding			skin(1)	1						GATCAGAGAGCAGGACTGTGAA	0.455		NA											39	80					0	0	0	0
F7	2155	broad.mit.edu	37	13	113770072	113770072	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr13:113770072G>T	uc001vsv.2	+	6	580	c.529G>T	c.(529-531)GGG>TGG	p.G177W	F7_uc010agp.1_Missense_Mutation_p.G170W|F7_uc001vsw.2_Missense_Mutation_p.G155W|F7_uc010tjt.1_Missense_Mutation_p.G108W	NM_000131	NP_000122	P08709	FA7_HUMAN	coagulation factor VII isoform a precursor	177	EGF-like 2.		G -> R (in FA7D).		anti-apoptosis|blood coagulation, extrinsic pathway|peptidyl-glutamic acid carboxylation|positive regulation of leukocyte chemotaxis|positive regulation of platelet-derived growth factor receptor signaling pathway|positive regulation of positive chemotaxis|positive regulation of protein kinase B signaling cascade|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|Golgi lumen|plasma membrane	calcium ion binding|glycoprotein binding|serine-type endopeptidase activity				0	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0364)|all_epithelial(44;0.0393)|Lung NSC(25;0.128)|Breast(118;0.188)	all cancers(43;0.0737)|Epithelial(84;0.213)|BRCA - Breast invasive adenocarcinoma(86;0.218)		Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Menadione(DB00170)	GTGCCACGAGGGGTACTCTCT	0.602		NA											7	24					0.00198382	0.0028924	1	0
POTEG	404785	broad.mit.edu	37	14	19553561	19553561	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:19553561C>G	uc001vuz.1	+	1	197	c.145C>G	c.(145-147)CAC>GAC	p.H49D	POTEG_uc001vva.1_RNA|POTEG_uc010ahc.1_RNA	NM_001005356	NP_001005356	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	49										ovary(1)	1						TTCTGGAGACCACGACGATTC	0.607		NA											24	556					0	0	0	0
OR4Q3	441669	broad.mit.edu	37	14	20216334	20216334	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:20216334C>A	uc010tkt.1	+	1	748	c.748C>A	c.(748-750)CTG>ATG	p.L250M		NM_172194	NP_751944	Q8NH05	OR4Q3_HUMAN	olfactory receptor, family 4, subfamily Q,	250	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)	3	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		AGTGGTCAGCCTGATCTTCGT	0.453		NA											35	226					1.97e-18	3.94e-18	1	0
OR4M1	441670	broad.mit.edu	37	14	20248502	20248502	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:20248502C>A	uc010tku.1	+	1	21	c.21C>A	c.(19-21)ACC>ACA	p.T7T		NM_001005500	NP_001005500	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M,	7	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CAAATTACACCAAGGTGACAG	0.338		NA											26	178					7.16e-05	0.000110528	1	0
OR4M1	441670	broad.mit.edu	37	14	20248683	20248683	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:20248683C>A	uc010tku.1	+	1	202	c.202C>A	c.(202-204)CTC>ATC	p.L68I		NM_001005500	NP_001005500	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M,	68	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TAATCTGGCCCTCCTTGATAT	0.423		NA											66	532					3.07e-33	6.5e-33	1	0
OR4K2	390431	broad.mit.edu	37	14	20345255	20345255	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:20345255A>T	uc001vwh.1	+	1	829	c.829A>T	c.(829-831)ATC>TTC	p.I277F		NM_001005501	NP_001005501	Q8NGD2	OR4K2_HUMAN	olfactory receptor, family 4, subfamily K,	277	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GTTTTATACCATCTTTACTCC	0.358		NA											23	119					0	0	0	0
OR4K14	122740	broad.mit.edu	37	14	20482729	20482729	+	Silent	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:20482729G>C	uc010tky.1	-	1	624	c.624C>G	c.(622-624)TCC>TCG	p.S208S		NM_001004712	NP_001004712	Q8NGD5	OR4KE_HUMAN	olfactory receptor, family 4, subfamily K,	208	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|large_intestine(1)	3	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2e-06)	GBM - Glioblastoma multiforme(265;0.00124)		AACAGCTCAAGGAAAGCAACC	0.502		NA											13	32					0	0	0	0
OR4K13	390433	broad.mit.edu	37	14	20502160	20502160	+	Missense_Mutation	SNP	G	G	T	rs150686832	by1000genomes	TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:20502160G>T	uc010tkz.1	-	1	758	c.758C>A	c.(757-759)CCG>CAG	p.P253Q		NM_001004714	NP_001004714	Q8NH42	OR4KD_HUMAN	olfactory receptor, family 4, subfamily K,	253	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		AAAGACACACGGAGCAAAGAA	0.413		NA											22	46					2.89e-11	5.25e-11	1	0
OR4L1	122742	broad.mit.edu	37	14	20528986	20528986	+	Silent	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:20528986A>G	uc001vwn.1	+	1	783	c.783A>G	c.(781-783)CCA>CCG	p.P261P		NM_001004717	NP_001004717	Q8NH43	OR4L1_HUMAN	olfactory receptor, family 4, subfamily L,	261	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		ATGTTTGGCCATTCAGTAGTT	0.403		NA											23	87					0	0	0	0
OR11G2	390439	broad.mit.edu	37	14	20666322	20666322	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:20666322C>T	uc010tlb.1	+	1	828	c.828C>T	c.(826-828)TTC>TTT	p.F276F		NM_001005503	NP_001005503	Q8NGC1	O11G2_HUMAN	olfactory receptor, family 11, subfamily G,	276	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00108)		Epithelial(56;9.76e-07)|all cancers(55;5.61e-06)	GBM - Glioblastoma multiforme(265;0.0144)		GAAAGGCTTTCTCCACCTGTG	0.443		NA											57	145					0	0	0	0
OR11H6	122748	broad.mit.edu	37	14	20692320	20692320	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:20692320C>A	uc010tlc.1	+	1	452	c.452C>A	c.(451-453)CCC>CAC	p.P151H		NM_001004480	NP_001004480	Q8NGC7	O11H6_HUMAN	olfactory receptor, family 11, subfamily H,	151	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(95;0.00108)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0143)		TTACACTACCCCTCCATCATG	0.423		NA											40	77					5.72e-15	1.11e-14	1	0
OR6S1	341799	broad.mit.edu	37	14	21109748	21109748	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:21109748G>T	uc001vxv.1	-	1	103	c.103C>A	c.(103-105)CTT>ATT	p.L35I		NM_001001968	NP_001001968	Q8NH40	OR6S1_HUMAN	olfactory receptor, family 6, subfamily S,	35	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00304)		Epithelial(56;1.23e-06)|all cancers(55;1.01e-05)	GBM - Glioblastoma multiforme(265;0.0135)		AGATAGACAAGAAGAAACACA	0.478		NA											37	93					2.47e-13	4.65e-13	1	0
LRFN5	145581	broad.mit.edu	37	14	42355978	42355978	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:42355978C>A	uc001wvm.2	+	3	1348	c.150C>A	c.(148-150)GAC>GAA	p.D50E	LRFN5_uc010ana.2_Missense_Mutation_p.D50E	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	50	Extracellular (Potential).|LRRNT.					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		CAAACATTGACAGAAGAACTG	0.413		NA								HNSCC(30;0.082)			15	23					1.5e-05	2.37e-05	1	0
FANCM	57697	broad.mit.edu	37	14	45669148	45669148	+	Silent	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:45669148T>C	uc001wwd.3	+	23	6183	c.6084T>C	c.(6082-6084)TAT>TAC	p.Y2028Y	FANCM_uc010anf.2_Silent_p.Y2002Y|FANCM_uc001wwe.3_Silent_p.Y1564Y|FANCM_uc010ang.2_Silent_p.Y1277Y	NM_020937	NP_065988	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	2028	Interaction with FAAP24 and EME1.				DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			ovary(3)|lung(2)|breast(2)	7						ATATTCACTATGTATTTGACA	0.338		NA						Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				23	56					0	0	0	0
SDCCAG1	9147	broad.mit.edu	37	14	50312932	50312932	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:50312932C>A	uc001wxc.2	-	4	351	c.283G>T	c.(283-285)GTG>TTG	p.V95L	SDCCAG1_uc010anj.1_Missense_Mutation_p.V95L|SDCCAG1_uc010tqi.1_Missense_Mutation_p.V95L|SDCCAG1_uc001wxe.2_Intron|SDCCAG1_uc010anq.1_5'UTR	NM_004713	NP_004704	O60524	NEMF_HUMAN	serologically defined colon cancer antigen 1	95						cytoplasm|nucleus					0	all_epithelial(31;0.000822)|Breast(41;0.0117)	all_lung(585;1.02e-05)		OV - Ovarian serous cystadenocarcinoma(311;5.99e-34)		ATTCTATCCACACCAAGCTGT	0.358		NA											13	32					2.32e-09	4.08e-09	1	0
NIN	51199	broad.mit.edu	37	14	51288662	51288662	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:51288662T>G	uc001wym.2	-	3	304	c.113A>C	c.(112-114)CAC>CCC	p.H38P	NIN_uc001wyi.2_Missense_Mutation_p.H38P|NIN_uc001wyj.2_RNA|NIN_uc001wyk.2_Missense_Mutation_p.H38P|NIN_uc010tqp.1_Missense_Mutation_p.H44P|NIN_uc001wyo.2_Missense_Mutation_p.H38P|NIN_uc001wyp.1_5'UTR	NM_182946	NP_891991	Q8N4C6	NIN_HUMAN	ninein isoform 5	38	EF-hand 1.				centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			skin(3)|ovary(1)|kidney(1)|central_nervous_system(1)	6	all_epithelial(31;0.00244)|Breast(41;0.127)					GCTCAACATGTGGCAAAGGTC	0.587		NA	T	PDGFRB	MPD								67	244					0	0	0	0
PYGL	5836	broad.mit.edu	37	14	51381466	51381466	+	Missense_Mutation	SNP	G	G	T	rs113993980		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:51381466G>T	uc001wyu.2	-	12	1598	c.1471C>A	c.(1471-1473)CGC>AGC	p.R491S	PYGL_uc010tqq.1_Missense_Mutation_p.R457S|PYGL_uc001wyv.2_Missense_Mutation_p.R165S	NM_002863	NP_002854	P06737	PYGL_HUMAN	liver glycogen phosphorylase isoform 1	491					glucose homeostasis|glucose metabolic process|glycogen catabolic process	cytosol|soluble fraction	AMP binding|ATP binding|bile acid binding|drug binding|glucose binding|glycogen phosphorylase activity|protein homodimerization activity|purine base binding|pyridoxal phosphate binding			skin(1)	1	all_epithelial(31;0.00825)|Breast(41;0.148)				Adenosine monophosphate(DB00131)|Pyridoxal Phosphate(DB00114)|Riboflavin(DB00140)	AGGAGCCAGCGCCTTGGAGTG	0.498		NA											17	57					2.35e-11	4.29e-11	1	0
PTGER2	5732	broad.mit.edu	37	14	52781592	52781592	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:52781592G>C	uc001wzr.2	+	1	577	c.326G>C	c.(325-327)TGC>TCC	p.C109S		NM_000956	NP_000947	P43116	PE2R2_HUMAN	prostaglandin E receptor 2 (subtype EP2), 53kDa	109	Extracellular (Potential).					integral to plasma membrane	prostaglandin E receptor activity			lung(1)|breast(1)	2	Breast(41;0.0639)|all_epithelial(31;0.0729)				Alprostadil(DB00770)|Iloprost(DB01088)	AGCCGCGCGTGCACCTACTTC	0.647		NA											23	67					0	0	0	0
SLC35F4	341880	broad.mit.edu	37	14	58056150	58056150	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:58056150A>G	uc001xdb.1	-	3	479	c.479T>C	c.(478-480)ATG>ACG	p.M160T	SLC35F4_uc010aoz.1_RNA|SLC35F4_uc010apa.1_Missense_Mutation_p.M1T	NM_001080455	NP_001073924			solute carrier family 35, member F4											ovary(2)	2						CTTCAGAACCATGGACGTGCA	0.443		NA											11	29					0	0	0	0
DHRS7	51635	broad.mit.edu	37	14	60622799	60622799	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:60622799G>T	uc001xes.2	-	2	389	c.205C>A	c.(205-207)CAG>AAG	p.Q69K	C14orf135_uc001xeq.2_Intron|DHRS7_uc001xet.2_Missense_Mutation_p.Q19K|DHRS7_uc001xeu.2_Missense_Mutation_p.Q69K	NM_016029	NP_057113	Q9Y394	DHRS7_HUMAN	dehydrogenase/reductase (SDR family) member 7	69	NAD (By similarity).						binding|oxidoreductase activity			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.121)		TTAGACAACTGGTAAGCCAGC	0.478		NA											23	67					2.89e-11	5.25e-11	1	0
SGPP1	81537	broad.mit.edu	37	14	64152979	64152979	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:64152979T>A	uc001xgj.2	-	3	1264	c.1170A>T	c.(1168-1170)TTA>TTT	p.L390F		NM_030791	NP_110418	Q9BX95	SGPP1_HUMAN	sphingosine-1-phosphate phosphatase 1	390						endoplasmic reticulum membrane|integral to membrane	dihydrosphingosine-1-phosphate phosphatase activity|sphingosine-1-phosphate phosphatase activity			central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.0056)|all cancers(60;0.0141)|BRCA - Breast invasive adenocarcinoma(234;0.103)		TTTTGCAGGCTAAAGGAATGG	0.373		NA											23	87					0	0	0	0
ZFP36L1	677	broad.mit.edu	37	14	69257126	69257126	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:69257126C>A	uc001xkh.1	-	2	271	c.141G>T	c.(139-141)GGG>GGT	p.G47G	ZFP36L1_uc001xki.1_Silent_p.G47G	NM_004926	NP_004917	Q07352	TISB_HUMAN	butyrate response factor 1	47					regulation of mRNA stability	cytosol|nucleus	DNA binding|mRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				all cancers(60;0.00203)|BRCA - Breast invasive adenocarcinoma(234;0.00205)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		GAGGGAAGCCCCCACCAGCAG	0.612		NA									OREG0022753	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	22					0.000274275	0.000411185	1	0
PCNX	22990	broad.mit.edu	37	14	71555910	71555910	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:71555910A>T	uc001xmo.2	+	30	5886	c.5440A>T	c.(5440-5442)AAT>TAT	p.N1814Y	PCNX_uc010are.1_Missense_Mutation_p.N1703Y|PCNX_uc010arf.1_Missense_Mutation_p.N602Y	NM_014982	NP_055797	Q96RV3	PCX1_HUMAN	pecanex-like 1	1814						integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		TCTTAACAGTAATTTAGAGTC	0.274		NA											14	53					0	0	0	0
ABCD4	5826	broad.mit.edu	37	14	74759551	74759551	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:74759551T>C	uc001xpr.2	-	9	988	c.836A>G	c.(835-837)TAT>TGT	p.Y279C	ABCD4_uc001xps.2_Missense_Mutation_p.Y120C|ABCD4_uc001xpt.2_Missense_Mutation_p.Y120C|ABCD4_uc010tur.1_Missense_Mutation_p.Y175C|ABCD4_uc001xpu.2_Missense_Mutation_p.Y16C|ABCD4_uc001xpv.2_RNA	NM_005050	NP_005041	O14678	ABCD4_HUMAN	ATP-binding cassette, sub-family D, member 4	279	ABC transmembrane type-1.|Helical; (Potential).					ATP-binding cassette (ABC) transporter complex|integral to membrane|peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			upper_aerodigestive_tract(2)|large_intestine(1)|ovary(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.00153)		GCTGCCCAGATAGTCAAAGGT	0.537		NA											22	47					0	0	0	0
LTBP2	4053	broad.mit.edu	37	14	74969972	74969972	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:74969972T>A	uc001xqa.2	-	33	5225	c.4838A>T	c.(4837-4839)GAC>GTC	p.D1613V		NM_000428	NP_000419	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding	1613	TB 4.				protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			liver(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		GGCCTCGCCGTCCTGGCAGCA	0.637		NA											19	35					0	0	0	0
FLRT2	23768	broad.mit.edu	37	14	86087868	86087868	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:86087868C>T	uc001xvr.2	+	2	777	c.10C>T	c.(10-12)CAG>TAG	p.Q4*	FLRT2_uc010atd.2_Nonsense_Mutation_p.Q4*	NM_013231	NP_037363	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	4					cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			ovary(3)|haematopoietic_and_lymphoid_tissue(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.0319)		AATGGGCCTACAGACCACAAA	0.443		NA											24	73					0	0	0	0
FLRT2	23768	broad.mit.edu	37	14	86088278	86088278	+	Silent	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:86088278G>C	uc001xvr.2	+	2	1187	c.420G>C	c.(418-420)CTG>CTC	p.L140L	FLRT2_uc010atd.2_Silent_p.L140L	NM_013231	NP_037363	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	140	LRR 4.|Extracellular (Potential).				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			ovary(3)|haematopoietic_and_lymphoid_tissue(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.0319)		AGCTGCACCTGGATGACAACT	0.488		NA											16	55					0	0	0	0
SMEK1	55671	broad.mit.edu	37	14	91948115	91948115	+	Silent	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:91948115T>A	uc001xzn.2	-	4	1542	c.720A>T	c.(718-720)CTA>CTT	p.L240L	SMEK1_uc001xzm.2_Silent_p.L240L|SMEK1_uc001xzo.2_Silent_p.L240L|SMEK1_uc010atz.2_Intron|SMEK1_uc001xzp.1_RNA|SMEK1_uc001xzq.1_Silent_p.L116L	NM_032560	NP_115949	Q6IN85	P4R3A_HUMAN	SMEK homolog 1, suppressor of mek1	240						microtubule organizing center|nucleus	protein binding				0		all_cancers(154;0.0691)|all_epithelial(191;0.219)		COAD - Colon adenocarcinoma(157;0.221)		CTGTTTTTGTTAGAAATTCCC	0.338		NA											20	54					0	0	0	0
RIN3	79890	broad.mit.edu	37	14	93118666	93118666	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:93118666C>G	uc001yap.2	+	6	1424	c.1272C>G	c.(1270-1272)GAC>GAG	p.D424E	RIN3_uc010auk.2_Missense_Mutation_p.D86E|RIN3_uc001yaq.2_Missense_Mutation_p.D349E|RIN3_uc001yar.1_Missense_Mutation_p.D86E|RIN3_uc001yas.1_Missense_Mutation_p.D86E	NM_024832	NP_079108	Q8TB24	RIN3_HUMAN	Ras and Rab interactor 3	424	Pro-rich.				endocytosis|signal transduction	cytoplasmic membrane-bounded vesicle|early endosome	GTPase activator activity|Ras GTPase binding			lung(2)|ovary(1)	3		all_cancers(154;0.0701)				GCCCTGAGGACACGCCCCGGG	0.642		NA											22	50					0	0	0	0
KIAA1409	57578	broad.mit.edu	37	14	94038416	94038416	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:94038416C>G	uc001ybv.1	+	12	1484	c.1401C>G	c.(1399-1401)TTC>TTG	p.F467L	KIAA1409_uc001ybs.1_Missense_Mutation_p.F467L	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	644						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		TAAAAGAATTCAGGGAAGTAT	0.289		NA											12	40					0	0	0	0
PRIMA1	145270	broad.mit.edu	37	14	94187840	94187840	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:94187840T>G	uc001ybw.1	-	5	454	c.412A>C	c.(412-414)AGT>CGT	p.S138R	PRIMA1_uc001ybx.1_RNA	NM_178013	NP_821092	Q86XR5	PRIMA_HUMAN	proline rich membrane anchor 1 precursor	138	Cytoplasmic (Potential).				neurotransmitter catabolic process	cell junction|integral to membrane|synapse				large_intestine(1)|skin(1)	2		all_cancers(154;0.127)		Epithelial(152;0.138)|COAD - Colon adenocarcinoma(157;0.229)		TGCGAAGCACTCATGGGATAC	0.587		NA											14	36					0	0	0	0
PPP4R4	57718	broad.mit.edu	37	14	94711942	94711942	+	Missense_Mutation	SNP	G	G	T	rs143566515		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:94711942G>T	uc001ycs.1	+	13	1517	c.1363G>T	c.(1363-1365)GAT>TAT	p.D455Y		NM_058237	NP_478144	Q6NUP7	PP4R4_HUMAN	HEAT-like repeat-containing protein isoform 1	455						cytoplasm|protein serine/threonine phosphatase complex	protein binding			skin(3)|upper_aerodigestive_tract(1)	4						TGCTCTTATAGATCATCTTCC	0.313		NA											24	66					3.6e-14	6.85e-14	1	0
SERPINA4	5267	broad.mit.edu	37	14	95033445	95033445	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:95033445G>A	uc001ydk.2	+	3	854	c.788G>A	c.(787-789)TGC>TAC	p.C263Y	SERPINA4_uc010avd.2_Missense_Mutation_p.C300Y|SERPINA4_uc001ydl.2_Missense_Mutation_p.C263Y	NM_006215	NP_006206	P29622	KAIN_HUMAN	serine (or cysteine) proteinase inhibitor, clade	263					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity			ovary(3)|skin(1)	4				COAD - Colon adenocarcinoma(157;0.211)		TACTTGCCCTGCTCGGTGCTA	0.493		NA											15	44					0	0	0	0
SERPINA5	5104	broad.mit.edu	37	14	95058512	95058512	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:95058512G>T	uc001ydm.2	+	6	1367	c.1157G>T	c.(1156-1158)AGG>ATG	p.R386M	SERPINA3_uc001ydo.3_Intron	NM_000624	NP_000615	P05154	IPSP_HUMAN	serine (or cysteine) proteinase inhibitor, clade	386					fusion of sperm to egg plasma membrane|regulation of proteolysis|spermatogenesis	extracellular region|membrane|protein complex	acrosin binding|heparin binding|protease binding|serine-type endopeptidase inhibitor activity			ovary(2)	2				COAD - Colon adenocarcinoma(157;0.21)	Drotrecogin alfa(DB00055)|Urokinase(DB00013)	GTGTTCAACAGGCCCTTTCTG	0.557		NA											135	323					8.32e-65	1.78e-64	1	0
GSC	145258	broad.mit.edu	37	14	95234860	95234861	+	Nonsense_Mutation	DNP	CC	CC	AA			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:95234860_95234861CC>AA	uc001ydu.2	-	3	888_889	c.741_742GG>TT	c.(739-744)GAGGAA>GATTAA	p.247_248EE>D*		NM_173849	NP_776248	P56915	GSC_HUMAN	goosecoid	247_248					gastrulation|middle ear morphogenesis		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(154;0.0896)|all_epithelial(191;0.219)		COAD - Colon adenocarcinoma(157;0.202)|Epithelial(152;0.239)		CTTTTACCTTCCTCTTCCCTCT	0.559		NA											40	104					0	0	0	0
DICER1	23405	broad.mit.edu	37	14	95582111	95582111	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr14:95582111G>T	uc001ydw.2	-	12	1982	c.1800C>A	c.(1798-1800)GAC>GAA	p.D600E	DICER1_uc001ydv.2_Missense_Mutation_p.D590E|DICER1_uc001ydx.2_Missense_Mutation_p.D600E	NM_030621	NP_085124	Q9UPY3	DICER_HUMAN	dicer1	600	Helicase C-terminal.				negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			skin(2)|ovary(1)|pancreas(1)|lung(1)	5		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		CAGGATCAATGTCAGTCTCAC	0.433		NA	Mis F|N			pleuropulmonary blastoma			DICER_1_syndrome_|Familial_Multinodular_Goiter_				24	44					2.4e-15	4.64e-15	1	0
NDN	4692	broad.mit.edu	37	15	23931753	23931753	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr15:23931753G>T	uc001ywk.2	-	1	698	c.612C>A	c.(610-612)GGC>GGA	p.G204G		NM_002487	NP_002478	Q99608	NECD_HUMAN	necdin	204	MAGE.				negative regulation of cell proliferation|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perikaryon	DNA binding				0		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;8.37e-11)|Epithelial(43;9.29e-10)|BRCA - Breast invasive adenocarcinoma(123;0.00179)|GBM - Glioblastoma multiforme(186;0.018)|Lung(196;0.153)		TCTCTCTGGCGCCGCGGCCCT	0.657		NA							Prader-Willi_syndrome				10	25					2.18e-05	3.43e-05	1	0
CHRFAM7A	89832	broad.mit.edu	37	15	30665184	30665184	+	Missense_Mutation	SNP	C	C	A	rs144150663		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr15:30665184C>A	uc001zdt.1	-	6	891	c.325G>T	c.(325-327)GTG>TTG	p.V109L	DKFZP434L187_uc001zds.2_RNA|CHRFAM7A_uc001zdu.1_Missense_Mutation_p.V18L|CHRFAM7A_uc010azn.2_Missense_Mutation_p.V18L|CHRFAM7A_uc001zdv.2_RNA	NM_139320	NP_647536	Q494W8	CRFM7_HUMAN	CHRNA7-FAM7A fusion isoform 1	109						integral to membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity			skin(1)	1		all_lung(180;3.42e-11)|Breast(32;0.000153)		all cancers(64;1.9e-15)|Epithelial(43;3.59e-12)|GBM - Glioblastoma multiforme(186;9e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)|Lung(196;0.153)		GGCTTACCCACTAGGTCCCAT	0.502		NA											41	84					1e-27	2.09e-27	1	0
RYR3	6263	broad.mit.edu	37	15	34040373	34040373	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr15:34040373G>A	uc001zhi.2	+	54	8118	c.8048G>A	c.(8047-8049)GGC>GAC	p.G2683D	RYR3_uc010bar.2_Missense_Mutation_p.G2683D	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	2683	3.|Cytoplasmic (By similarity).|4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CTGGCTGTGGGCTGGACTGTG	0.522		NA											22	28					0	0	0	0
PLA2G4F	255189	broad.mit.edu	37	15	42442599	42442599	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr15:42442599T>G	uc001zoz.2	-	9	920	c.857A>C	c.(856-858)GAG>GCG	p.E286A	PLA2G4F_uc001zoy.2_5'Flank|PLA2G4F_uc010bcr.2_Missense_Mutation_p.E37A|PLA2G4F_uc001zpa.2_Missense_Mutation_p.E37A|PLA2G4F_uc010bcs.2_Missense_Mutation_p.E73A	NM_213600	NP_998765	Q68DD2	PA24F_HUMAN	phospholipase A2, group IVF	286					phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity			ovary(4)	4		all_cancers(109;4.82e-12)|all_epithelial(112;5.64e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.97e-07)		ACACTGTTCCTCCTGGCCTAG	0.627		NA											9	14					0	0	0	0
SPG11	80208	broad.mit.edu	37	15	44888469	44888469	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr15:44888469A>G	uc001ztx.2	-	25	4277	c.4246T>C	c.(4246-4248)TCC>CCC	p.S1416P	SPG11_uc010ueh.1_Missense_Mutation_p.S1416P|SPG11_uc010uei.1_Missense_Mutation_p.S1416P|SPG11_uc001zty.1_Missense_Mutation_p.S145P	NM_025137	NP_079413	Q96JI7	SPTCS_HUMAN	spatacsin isoform 1	1416	Cytoplasmic (Potential).				cell death	cytosol|integral to membrane|nucleus	protein binding			ovary(4)|skin(1)	5		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		TCCATTTTGGAGGTGGGCACT	0.463		NA											3	93					0	0	0	0
SLC12A1	6557	broad.mit.edu	37	15	48577336	48577336	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr15:48577336C>A	uc001zwn.3	+	21	2735	c.2519C>A	c.(2518-2520)GCA>GAA	p.A840E	SLC12A1_uc010uew.1_Missense_Mutation_p.A646E|SLC12A1_uc001zwq.3_Missense_Mutation_p.A611E|SLC12A1_uc001zwr.3_Missense_Mutation_p.A567E	NM_000338	NP_000329	Q13621	S12A1_HUMAN	sodium potassium chloride cotransporter 2	840	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport	integral to membrane|membrane fraction	sodium:potassium:chloride symporter activity			ovary(1)|central_nervous_system(1)	2		all_lung(180;0.00219)		all cancers(107;1.76e-09)|GBM - Glioblastoma multiforme(94;1.48e-06)	Bumetanide(DB00887)|Chlormerodrin(DB00534)|Chlorthalidone(DB00310)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Metolazone(DB00524)|Potassium Chloride(DB00761)|Torasemide(DB00214)|Trichlormethiazide(DB01021)	GAGAGACTAGCATTGGAAGCG	0.373		NA											28	43					1.4e-14	2.68e-14	1	0
HDC	3067	broad.mit.edu	37	15	50534984	50534984	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr15:50534984C>A	uc001zxz.2	-	12	1568	c.1462G>T	c.(1462-1464)GGG>TGG	p.G488W	HDC_uc001zxy.2_Missense_Mutation_p.G231W|HDC_uc010uff.1_Missense_Mutation_p.G455W	NM_002112	NP_002103	P19113	DCHS_HUMAN	histidine decarboxylase	488					catecholamine biosynthetic process|histidine metabolic process		histidine decarboxylase activity			large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6		all_lung(180;0.0138)		all cancers(107;1.12e-06)|GBM - Glioblastoma multiforme(94;9.95e-05)	L-Histidine(DB00117)|Pyridoxal Phosphate(DB00114)	ATGAGGTTCCCAACCCGAGGG	0.567		NA											16	30					1.57e-10	2.84e-10	1	0
ITGA11	22801	broad.mit.edu	37	15	68650827	68650827	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr15:68650827T>C	uc002ari.2	-	6	656	c.569A>G	c.(568-570)AAA>AGA	p.K190R	ITGA11_uc010bib.2_Missense_Mutation_p.K190R	NM_001004439	NP_001004439	Q9UKX5	ITA11_HUMAN	integrin, alpha 11 precursor	190	VWFA.|Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			kidney(2)|pancreas(1)	3					Tirofiban(DB00775)	GTAAAACTTTTTCAGGATGTT	0.542		NA											6	13					0	0	0	0
TLE3	7090	broad.mit.edu	37	15	70351092	70351092	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr15:70351092G>A	uc002asm.2	-	11	1947	c.828C>T	c.(826-828)GCC>GCT	p.A276A	TLE3_uc002ask.2_Silent_p.A220A|TLE3_uc002asl.2_Silent_p.A281A|TLE3_uc010ukd.1_Silent_p.A269A|TLE3_uc010bik.1_Intron|TLE3_uc010bil.1_Silent_p.A276A|TLE3_uc002asn.2_Silent_p.A276A|TLE3_uc002asp.2_Silent_p.A276A|TLE3_uc002aso.2_Silent_p.A276A	NM_005078	NP_005069	Q04726	TLE3_HUMAN	transducin-like enhancer protein 3 isoform a	276	Pro/Ser-rich.				organ morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|protein binding			lung(2)	2						TCAGGCTACGGGCCTTGTCCA	0.582		NA											5	2					0	0	0	0
UBE2Q2	92912	broad.mit.edu	37	15	76171514	76171514	+	Silent	SNP	T	T	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr15:76171514T>G	uc002bbg.2	+	8	1196	c.810T>G	c.(808-810)CTT>CTG	p.L270L	UBE2Q2_uc002bbh.2_Silent_p.L235L|UBE2Q2_uc010umn.1_Silent_p.L254L|UBE2Q2_uc002bbi.2_Silent_p.L151L	NM_173469	NP_775740	Q8WVN8	UB2Q2_HUMAN	ubiquitin-conjugating enzyme E2Q 2 isoform 1	270					protein K48-linked ubiquitination	cytoplasm	ATP binding|ubiquitin-protein ligase activity			ovary(2)	2						ATATTTTGCTTAACTTCTCTT	0.219		NA											12	20					0	0	0	0
ACAN	176	broad.mit.edu	37	15	89401765	89401765	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr15:89401765C>A	uc010upo.1	+	12	6323	c.5949C>A	c.(5947-5949)GAC>GAA	p.D1983E	ACAN_uc010upp.1_Missense_Mutation_p.D1983E|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	1983					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			GATTTCTGGACCTAAGTGGGC	0.542		NA											29	37					1.16e-09	2.05e-09	1	0
MESP2	145873	broad.mit.edu	37	15	90320436	90320436	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr15:90320436C>G	uc002bon.2	+	1	848	c.848C>G	c.(847-849)TCG>TGG	p.S283W	MESP2_uc010uqa.1_Intron	NM_001039958	NP_001035047	Q0VG99	MESP2_HUMAN	mesoderm posterior 2 homolog	283					Notch signaling pathway	nucleus	DNA binding				0	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)			TGGACGCAGTCGTCCCCAGAG	0.647		NA											10	7					0	0	0	0
PCSK6	5046	broad.mit.edu	37	15	101872152	101872152	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr15:101872152C>T	uc002bwy.2	-	15	2257	c.1943G>A	c.(1942-1944)CGG>CAG	p.R648Q	PCSK6_uc010bpd.2_Missense_Mutation_p.R444Q|PCSK6_uc010bpe.2_Missense_Mutation_p.R648Q|PCSK6_uc002bxa.2_Missense_Mutation_p.R648Q|PCSK6_uc002bxb.2_Missense_Mutation_p.R648Q	NM_002570	NP_002561	P29122	PCSK6_HUMAN	paired basic amino acid cleaving system 4	648					glycoprotein metabolic process|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|regulation of BMP signaling pathway|secretion by cell	cell surface|endomembrane system|endoplasmic reticulum|extracellular matrix|extracellular space|Golgi lumen|membrane|soluble fraction	eukaryotic cell surface binding|heparin binding|nerve growth factor binding|serine-type endopeptidase activity			pancreas(2)	2	Lung NSC(78;0.00102)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000803)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			CTCCAGCATCCGCGAGCGGGA	0.567		NA											12	19					0	0	0	0
OR4F6	390648	broad.mit.edu	37	15	102346444	102346444	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr15:102346444A>T	uc010utr.1	+	1	522	c.522A>T	c.(520-522)TTA>TTT	p.L174F		NM_001005326	NP_001005326	Q8NGB9	OR4F6_HUMAN	olfactory receptor, family 4, subfamily F,	174	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00039)|Lung(145;0.17)|LUSC - Lung squamous cell carcinoma(107;0.187)			CTAATGAATTAGATAGTTTCT	0.373		NA											48	80					0	0	0	0
TMEM8A	58986	broad.mit.edu	37	16	422106	422106	+	Missense_Mutation	SNP	C	C	G	rs150493488		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:422106C>G	uc002cgu.3	-	13	2326	c.2197G>C	c.(2197-2199)GCA>CCA	p.A733P	MRPL28_uc010bqu.1_5'Flank|MRPL28_uc002cgr.1_5'Flank|MRPL28_uc002cgs.1_5'Flank|MRPL28_uc002cgt.1_5'Flank|TMEM8A_uc002cgv.3_Missense_Mutation_p.A540P	NM_021259	NP_067082	Q9HCN3	TMM8A_HUMAN	transmembrane protein 8 (five membrane-spanning	733	Helical; (Potential).				cell adhesion	integral to plasma membrane				central_nervous_system(2)|pancreas(1)	3						AGCAAGGCTGCGCTCCCGGCC	0.607		NA											55	62					0	0	0	0
PKD1	5310	broad.mit.edu	37	16	2159077	2159077	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:2159077C>A	uc002cos.1	-	15	6300	c.6091G>T	c.(6091-6093)GTG>TTG	p.V2031L	PKD1_uc002cot.1_Missense_Mutation_p.V2031L	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	2031	PKD 16.|Extracellular (Potential).				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						CCCGCGGCCACGGGCGTGTAG	0.677		NA											45	48					2.22e-12	4.09e-12	1	0
PKD1	5310	broad.mit.edu	37	16	2167056	2167056	+	Splice_Site	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:2167056T>C	uc002cos.1	-	7	1595	c.1386_splice	c.e7-1	p.R462_splice	PKD1_uc002cot.1_Splice_Site_p.R462_splice	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor						calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						TCTAGGCTCCTGGGGGCGGGT	0.522		NA											9	15					0	0	0	0
ABCA3	21	broad.mit.edu	37	16	2329015	2329015	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:2329015C>T	uc002cpy.1	-	29	5188	c.4476G>A	c.(4474-4476)GGG>GGA	p.G1492G	ABCA3_uc010bsk.1_Silent_p.G1434G	NM_001089	NP_001080	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A member 3	1492	ABC transporter 2.				response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(5)|ovary(5)|central_nervous_system(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	16		Ovarian(90;0.17)				CCACGCAGGCCCCGATGTGGC	0.652		NA											41	104					0	0	0	0
AMDHD2	51005	broad.mit.edu	37	16	2578355	2578355	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:2578355G>C	uc002cqq.2	+	7	933	c.836G>C	c.(835-837)CGG>CCG	p.R279P	AMDHD2_uc002cqp.2_Missense_Mutation_p.R279P|AMDHD2_uc010uwc.1_Missense_Mutation_p.R279P|AMDHD2_uc010uwd.1_Missense_Mutation_p.R43P	NM_015944	NP_057028	Q9Y303	NAGA_HUMAN	amidohydrolase domain containing 2 isoform 1	279					N-acetylglucosamine metabolic process		N-acetylglucosamine-6-phosphate deacetylase activity			skin(2)|large_intestine(1)|breast(1)	4						GCCGCCCTGCGGATCGCCCAC	0.672		NA											15	68					0	0	0	0
MEFV	4210	broad.mit.edu	37	16	3306443	3306443	+	Silent	SNP	T	T	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:3306443T>G	uc002cun.1	-	1	185	c.145A>C	c.(145-147)AGG>CGG	p.R49R		NM_000243	NP_000234	O15553	MEFV_HUMAN	Mediterranean fever protein	49	DAPIN.				inflammatory response	cytoplasm|microtubule|microtubule associated complex|nucleus	actin binding|zinc ion binding			central_nervous_system(2)|skin(2)|ovary(1)|lung(1)	6					Colchicine(DB01394)	TTCACCGGCCTGGCTCTCTGG	0.602		NA											68	85					0	0	0	0
GRIN2A	2903	broad.mit.edu	37	16	9923416	9923416	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:9923416C>G	uc002czo.3	-	9	2419	c.1871G>C	c.(1870-1872)GGG>GCG	p.G624A	GRIN2A_uc010uym.1_Missense_Mutation_p.G624A|GRIN2A_uc010uyn.1_Missense_Mutation_p.G467A|GRIN2A_uc002czr.3_Missense_Mutation_p.G624A	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	624	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GCTGGTGGTCCCTTTAGGATT	0.493		NA											18	85					0	0	0	0
CIITA	4261	broad.mit.edu	37	16	10971201	10971201	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:10971201C>T	uc002dai.3	+	1	147	c.14C>T	c.(13-15)GCT>GTT	p.A5V	CIITA_uc002daj.3_Missense_Mutation_p.A5V|CIITA_uc002dak.3_Missense_Mutation_p.A5V|CIITA_uc002dag.2_Missense_Mutation_p.A5V|CIITA_uc002dah.2_Missense_Mutation_p.A5V|CIITA_uc010bup.1_Missense_Mutation_p.A5V	NM_000246	NP_000237	P33076	C2TA_HUMAN	class II transactivator	5					interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|response to antibiotic|transcription, DNA-dependent	nucleus	activating transcription factor binding|ATP binding|protein C-terminus binding|protein complex binding|transcription coactivator activity|transcription regulatory region DNA binding			central_nervous_system(1)	1						CGTTGCCTGGCTCCACGCCCT	0.602		NA	T	FLJ27352|CD274|CD273|RALGDS|RUNDC2A|C16orf75	PMBL|Hodgkin Lymphona|								6	13					0	0	0	0
LITAF	9516	broad.mit.edu	37	16	11647435	11647435	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:11647435C>A	uc002daz.2	-	3	564	c.331G>T	c.(331-333)GCC>TCC	p.A111S	LITAF_uc002dba.2_Missense_Mutation_p.A111S|LITAF_uc002dbb.2_Missense_Mutation_p.A111S|LITAF_uc002dbc.2_Missense_Mutation_p.A111S|LITAF_uc002dbd.2_Missense_Mutation_p.A111S	NM_004862	NP_004853	Q99732	LITAF_HUMAN	lipopolysaccharide-induced TNF-alpha factor	111					apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|lysosomal membrane	signal transducer activity|WW domain binding			liver(1)	1						AGAGCACCGGCGTTATAGGAC	0.592		NA											13	39					9.31e-06	1.49e-05	1	0
GP2	2813	broad.mit.edu	37	16	20327337	20327337	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:20327337C>A	uc002dgv.2	-	10	1534	c.1451G>T	c.(1450-1452)AGT>ATT	p.S484I	GP2_uc002dgw.2_Missense_Mutation_p.S481I|GP2_uc002dgx.2_Missense_Mutation_p.S337I|GP2_uc002dgy.2_Missense_Mutation_p.S334I	NM_001007240	NP_001007241	P55259	GP2_HUMAN	zymogen granule membrane glycoprotein 2 isoform	484	ZP.					anchored to membrane|extracellular region|plasma membrane				ovary(3)|skin(1)	4						CGGTACTTCACTGCGGACTTG	0.483		NA											24	85					2.8e-10	5.02e-10	1	0
PDILT	204474	broad.mit.edu	37	16	20370759	20370759	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:20370759G>C	uc002dhc.1	-	12	1860	c.1637C>G	c.(1636-1638)TCC>TGC	p.S546C		NM_174924	NP_777584	Q8N807	PDILT_HUMAN	protein disulfide isomerase-like, testis	546					cell differentiation|cell redox homeostasis|multicellular organismal development|spermatogenesis	endoplasmic reticulum	isomerase activity			large_intestine(1)	1						TTCCAGCTTGGATACGTACTT	0.512		NA											50	245					0	0	0	0
ACSM5	54988	broad.mit.edu	37	16	20442556	20442556	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:20442556G>A	uc002dhe.2	+	10	1368	c.1221G>A	c.(1219-1221)GAG>GAA	p.E407E		NM_017888	NP_060358	Q6NUN0	ACSM5_HUMAN	acyl-CoA synthetase medium-chain family member 5	407					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			ovary(2)	2						TGGATGATGAGGGCAACGTCC	0.557		NA											37	129					0	0	0	0
DNAH3	55567	broad.mit.edu	37	16	20948070	20948070	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:20948070C>T	uc010vbe.1	-	60	11760	c.11760G>A	c.(11758-11760)GTG>GTA	p.V3920V	DNAH3_uc010vbd.1_Silent_p.V1355V	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3920					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		GCACTTTACCCACAAGCATGC	0.572		NA											7	17					0	0	0	0
VWA3A	146177	broad.mit.edu	37	16	22126703	22126703	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:22126703A>G	uc010vbq.1	+	9	821	c.725A>G	c.(724-726)CAG>CGG	p.Q242R	VWA3A_uc010bxc.2_Missense_Mutation_p.Q229R	NM_173615	NP_775886	A6NCI4	VWA3A_HUMAN	von Willebrand factor A domain containing 3A	242						extracellular region				skin(1)	1				GBM - Glioblastoma multiforme(48;0.0439)		AAGACGCTGCAGCCTGATGGA	0.453		NA											3	17					0	0	0	0
CHP2	63928	broad.mit.edu	37	16	23768878	23768878	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:23768878A>G	uc002dmb.1	+	7	988	c.565A>G	c.(565-567)AAA>GAA	p.K189E		NM_022097	NP_071380	O43745	CHP2_HUMAN	hepatocellular carcinoma antigen gene 520	189							calcium ion binding			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(48;0.0144)		CGTTGAGCAAAAAATGAGCAT	0.527		NA											57	177					0	0	0	0
SPN	6693	broad.mit.edu	37	16	29675891	29675891	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:29675891A>C	uc002dtm.2	+	2	978	c.842A>C	c.(841-843)CAG>CCG	p.Q281P	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SPN_uc002dtn.2_Missense_Mutation_p.Q281P|SPN_uc010bzd.2_RNA	NM_001030288	NP_001025459	P16150	LEUK_HUMAN	sialophorin precursor	281	Cytoplasmic (Potential).				blood coagulation|cellular defense response|chemotaxis|defense response to bacterium|establishment or maintenance of cell polarity|immune response|leukocyte migration|negative regulation of cell adhesion|positive regulation of tumor necrosis factor biosynthetic process	extracellular space|integral to plasma membrane	bacterial cell surface binding|transmembrane receptor activity			central_nervous_system(2)	2						CGCCGGCGGCAGAAGCGGCGG	0.697		NA											8	20					0	0	0	0
TBX6	6911	broad.mit.edu	37	16	30100304	30100304	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:30100304C>T	uc010veh.1	-	4	641	c.581G>A	c.(580-582)CGT>CAT	p.R194H	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|TBX6_uc002dwk.1_Missense_Mutation_p.R194H	NM_004608	NP_004599	O95947	TBX6_HUMAN	T-box 6	194	T-box.				anatomical structure morphogenesis|mesoderm development|multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2						GAGCTTGACACGATGGAAAGA	0.647		NA											44	122					0	0	0	0
ZNF629	23361	broad.mit.edu	37	16	30794552	30794552	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:30794552C>A	uc002dzs.1	-	3	1305	c.1097G>T	c.(1096-1098)CGG>CTG	p.R366L		NM_001080417	NP_001073886	Q9UEG4	ZN629_HUMAN	zinc finger protein 629	366	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			Colorectal(24;0.198)			CAGGTGAGTCCGCTGGTGCTT	0.662		NA											19	25					2.58e-16	5.08e-16	1	0
SALL1	6299	broad.mit.edu	37	16	51175026	51175026	+	Silent	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:51175026C>G	uc010vgs.1	-	2	1138	c.1107G>C	c.(1105-1107)GCG>GCC	p.A369A	SALL1_uc010vgr.1_Silent_p.A272A|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	369					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			ATGATGAGACCGCTGGGTTGC	0.512		NA											14	37					0	0	0	0
IRX6	79190	broad.mit.edu	37	16	55360356	55360356	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:55360356T>A	uc002ehy.2	+	2	687	c.154T>A	c.(154-156)TAC>AAC	p.Y52N	IRX6_uc002ehx.2_Missense_Mutation_p.Y52N|IRX6_uc010ccb.1_RNA	NM_024335	NP_077311	P78412	IRX6_HUMAN	iroquois homeobox protein 6	52						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(5)|ovary(1)	6						CTGCGCACCCTACGATAGTCG	0.652		NA											15	15					0	0	0	0
CDH11	1009	broad.mit.edu	37	16	65016141	65016141	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:65016141C>T	uc002eoi.2	-	8	1497	c.1063G>A	c.(1063-1065)GAC>AAC	p.D355N	CDH11_uc010cdn.2_Intron|CDH11_uc002eoj.2_Missense_Mutation_p.D355N|CDH11_uc010vin.1_Missense_Mutation_p.D229N|CDH11_uc002eok.1_RNA	NM_001797	NP_001788	P55287	CAD11_HUMAN	cadherin 11, type 2 preproprotein	355	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			lung(10)|ovary(3)|skin(1)	14		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		AACTTCGGGTCGATGTGCACG	0.468		NA	T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			19	22					0	0	0	0
TMED6	146456	broad.mit.edu	37	16	69377541	69377541	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:69377541G>A	uc002exc.1	-	4	525	c.492C>T	c.(490-492)GAC>GAT	p.D164D		NM_144676	NP_653277	Q8WW62	TMED6_HUMAN	transmembrane emp24 protein transport domain	164	Lumenal (Potential).				transport	endoplasmic reticulum membrane|integral to membrane				ovary(1)	1						TTTGTGTGCCGTCCTATGAGA	0.428		NA											30	29					0	0	0	0
PLCG2	5336	broad.mit.edu	37	16	81979842	81979842	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:81979842G>C	uc002fgt.2	+	31	3696	c.3544G>C	c.(3544-3546)GTT>CTT	p.V1182L		NM_002661	NP_002652	P16885	PLCG2_HUMAN	phospholipase C, gamma 2	1182					intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			large_intestine(4)|lung(2)|ovary(1)|skin(1)	8						TTCCCTCCTGGTTTTCTGTGA	0.527		NA											24	44					0	0	0	0
MYO1C	4641	broad.mit.edu	37	17	1386207	1386207	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:1386207T>G	uc002fsp.2	-	4	714	c.494A>C	c.(493-495)GAG>GCG	p.E165A	MYO1C_uc002fsn.2_Missense_Mutation_p.E146A|MYO1C_uc002fso.2_Missense_Mutation_p.E130A|MYO1C_uc010vqj.1_Missense_Mutation_p.E130A|MYO1C_uc010vqk.1_Missense_Mutation_p.E141A	NM_001080779	NP_001074248	O00159	MYO1C_HUMAN	myosin IC isoform a	165	Myosin head-like.			E -> Q (in Ref. 1; CAA67131).	mRNA transport|protein transport|transmembrane transport	basal plasma membrane|cytoplasm|filamentous actin|lateral plasma membrane|nuclear pore|nucleolus|nucleoplasm|stereocilium membrane	actin binding|ATP binding|calmodulin binding|motor activity				0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		ACCTCCGCGCTCGGGGGCTGG	0.632		NA											13	30					0	0	0	0
SPNS3	201305	broad.mit.edu	37	17	4350211	4350211	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:4350211G>A	uc002fxt.2	+	5	619	c.575G>A	c.(574-576)GGG>GAG	p.G192E	SPNS3_uc002fxu.2_Missense_Mutation_p.G65E	NM_182538	NP_872344	Q6ZMD2	SPNS3_HUMAN	spinster homolog 3	192	Helical; (Potential).				lipid transport|transmembrane transport	integral to membrane				large_intestine(1)	1						TACGTGCTGGGGTCGGCTGTG	0.652		NA											21	37					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7577138	7577138	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:7577138C>G	uc002gim.2	-	8	994	c.800G>C	c.(799-801)CGG>CCG	p.R267P	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R267P|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R135P|TP53_uc010cng.1_Missense_Mutation_p.R135P|TP53_uc002gii.1_Missense_Mutation_p.R135P|TP53_uc010cnh.1_Missense_Mutation_p.R267P|TP53_uc010cni.1_Missense_Mutation_p.R267P|TP53_uc002gij.2_Missense_Mutation_p.R267P	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	267	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> H (in a sporadic cancer; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R267W(20)|p.R267P(13)|p.0?(7)|p.R267Q(7)|p.R267R(5)|p.?(3)|p.G262_F270delGNLLGRNSF(2)|p.G266_E271delGRNSFE(2)|p.G262_S269delGNLLGRNS(2)|p.G266fs*4(1)|p.R267fs*78(1)|p.N268fs*77(1)|p.L265_K305del41(1)|p.R267G(1)|p.E258fs*71(1)|p.L265_R267delLGR(1)|p.R267L(1)|p.G266_N268delGRN(1)|p.G262fs*2(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AAAGCTGTTCCGTCCCAGTAG	0.527		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			23	17					0	0	0	0
DNAH2	146754	broad.mit.edu	37	17	7689567	7689567	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:7689567C>T	uc002giu.1	+	39	6269	c.6255C>T	c.(6253-6255)TGC>TGT	p.C2085C		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	2085	AAA 2 (By similarity).|ATP (Potential).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				TCGTGGGCTGCACGGGCAGCG	0.577		NA											19	54					0	0	0	0
ALOX12B	242	broad.mit.edu	37	17	7977057	7977057	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:7977057C>G	uc002gjy.1	-	13	1934	c.1673G>C	c.(1672-1674)CGA>CCA	p.R558P		NM_001139	NP_001130	O75342	LX12B_HUMAN	arachidonate 12-lipoxygenase, 12R type	558	Lipoxygenase.				epidermis development|leukotriene biosynthetic process		arachidonate 12-lipoxygenase activity|iron ion binding|lipoxygenase activity				0						AGGCACGGTTCGCAAGCACCT	0.627		NA								Multiple Myeloma(8;0.094)	OREG0024152	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	29					0	0	0	0
SPDYE4	388333	broad.mit.edu	37	17	8656718	8656718	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:8656718G>A	uc010cnz.1	-	5	752	c.575C>T	c.(574-576)CCC>CTC	p.P192L		NM_001128076	NP_001121548	A6NLX3	SPDE4_HUMAN	speedy homolog E4	192											0						ATGGAACAAGGGTCGCTGGGA	0.567		NA											5	14					0	0	0	0
MYH8	4626	broad.mit.edu	37	17	10304018	10304018	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:10304018G>A	uc002gmm.2	-	27	3519	c.3424C>T	c.(3424-3426)CTC>TTC	p.L1142F	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	1142	Potential.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						TCCCGGGAGAGGTCAGAGCGC	0.582		NA							Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				48	119					0	0	0	0
MYH4	4622	broad.mit.edu	37	17	10348361	10348361	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:10348361G>A	uc002gmn.2	-	37	5509	c.5398C>T	c.(5398-5400)CGT>TGT	p.R1800C	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	1800	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						TCATCCAGACGGAGCTGCAGA	0.562		NA											60	111					0	0	0	0
MYH4	4622	broad.mit.edu	37	17	10354160	10354160	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:10354160G>T	uc002gmn.2	-	29	4029	c.3918C>A	c.(3916-3918)TCC>TCA	p.S1306S	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	1306	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						GTTTGCCTCGGGATAGCTGAG	0.393		NA											31	57					1.56e-20	3.17e-20	1	0
MYH2	4620	broad.mit.edu	37	17	10424725	10424725	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:10424725C>T	uc010coi.2	-	40	5826	c.5698G>A	c.(5698-5700)GCT>ACT	p.A1900T	uc002gml.1_Intron|MYH1_uc002gmo.2_5'Flank|MYH2_uc002gmp.3_Missense_Mutation_p.A1900T|MYH2_uc010coj.2_Missense_Mutation_p.A667T	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1900	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						CGGAATTTAGCTAGATTGGTG	0.473		NA											44	118					0	0	0	0
MYH2	4620	broad.mit.edu	37	17	10428788	10428788	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:10428788C>T	uc010coi.2	-	32	4645	c.4517G>A	c.(4516-4518)CGA>CAA	p.R1506Q	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.R1506Q|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1506	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle	p.R1506*(1)		ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						TTTGTTCTCTCGCTTCAGGGT	0.428		NA											27	74					0	0	0	0
MYH2	4620	broad.mit.edu	37	17	10433044	10433044	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:10433044G>T	uc010coi.2	-	24	3082	c.2954C>A	c.(2953-2955)ACA>AAA	p.T985K	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.T985K|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	985	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						CATCTCTTCTGTGAGGTTTTT	0.478		NA											73	152					4.81e-37	1.02e-36	1	0
DNAH9	1770	broad.mit.edu	37	17	11522951	11522951	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:11522951G>C	uc002gne.2	+	6	1271	c.1203G>C	c.(1201-1203)TTG>TTC	p.L401F		NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	401	Potential.|Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CAGACACTTTGAGCTTCTTCA	0.443		NA											45	103					0	0	0	0
DNAH9	1770	broad.mit.edu	37	17	11648295	11648295	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:11648295T>A	uc002gne.2	+	31	6361	c.6293T>A	c.(6292-6294)TTT>TAT	p.F2098Y	DNAH9_uc010coo.2_Missense_Mutation_p.F1392Y	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	2098					cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GGGGACCTCTTTCCCGCCCTG	0.562		NA											18	49					0	0	0	0
MYOCD	93649	broad.mit.edu	37	17	12620739	12620739	+	Splice_Site	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:12620739G>T	uc002gnn.2	+	4	552	c.253_splice	c.e4+1	p.A85_splice	MYOCD_uc002gno.2_Splice_Site_p.A85_splice|MYOCD_uc002gnp.1_5'Flank	NM_153604	NP_705832	Q8IZQ8	MYCD_HUMAN	myocardin isoform 2						cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			central_nervous_system(2)|skin(2)|ovary(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		ATACTCCAAGGTAAGGCTGCA	0.443		NA											7	23					0.00198382	0.0028924	1	0
KCNJ12	3768	broad.mit.edu	37	17	21318738	21318738	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:21318738C>T	uc002gyv.1	+	3	789	c.84C>T	c.(82-84)GCC>GCT	p.A28A		NM_021012	NP_066292	Q14500	IRK12_HUMAN	potassium inwardly-rectifying channel, subfamily	28	Cytoplasmic (By similarity).				blood circulation|muscle contraction|regulation of heart contraction|synaptic transmission	integral to membrane	inward rectifier potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			ovary(3)|skin(1)	4				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)	Dofetilide(DB00204)	TGTCGGGCGCCAACGGCTTCG	0.657		NA								Prostate(3;0.18)			5	43					0	0	0	0
CCL7	6354	broad.mit.edu	37	17	32597383	32597383	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:32597383C>A	uc002hhz.2	+	1	144	c.74C>A	c.(73-75)CCA>CAA	p.P25Q	CCL7_uc010ctf.2_RNA	NM_006273	NP_006264	P80098	CCL7_HUMAN	chemokine (C-C motif) ligand 7 precursor	25					cell-cell signaling|cellular calcium ion homeostasis|chemotaxis|immune response|inflammatory response|signal transduction	extracellular space	chemokine activity|heparin binding			ovary(1)	1	Breast(3;0.00224)	Breast(31;0.151)|Ovarian(249;0.17)		BRCA - Breast invasive adenocarcinoma(366;0.155)		CTTGCTCAGCCAGGTAAGGTC	0.552		NA											24	44					9.96e-16	1.94e-15	1	0
CCL8	6355	broad.mit.edu	37	17	32646545	32646545	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:32646545T>C	uc002hib.2	+	1	480	c.25T>C	c.(25-27)TGC>CGC	p.C9R		NM_005623	NP_005614	P80075	CCL8_HUMAN	small inducible cytokine A8 precursor	9					calcium ion transport|cell-cell signaling|chemotaxis|exocytosis|immune response|inflammatory response|response to virus	extracellular space	chemokine activity|heparin binding|signal transducer activity				0		Ovarian(249;0.0443)|Breast(31;0.151)				AGCGCTTCTGTGCCTGCTGCT	0.527		NA											35	49					0	0	0	0
ACACA	31	broad.mit.edu	37	17	35468548	35468548	+	Silent	SNP	T	T	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:35468548T>G	uc002hnm.2	-	52	6563	c.6372A>C	c.(6370-6372)GTA>GTC	p.V2124V	ACACA_uc002hnk.2_Silent_p.V2046V|ACACA_uc002hnl.2_Silent_p.V2066V|ACACA_uc002hnn.2_Silent_p.V2124V|ACACA_uc002hno.2_Silent_p.V2161V|ACACA_uc010cuy.2_Silent_p.V769V|ACACA_uc010wdb.1_Silent_p.V162V|ACACA_uc010wdc.1_Silent_p.V250V	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	2124	Carboxyltransferase.				acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	ATTTGATTTCTACTGTCCCTT	0.458		NA											27	71					0	0	0	0
RPL23	9349	broad.mit.edu	37	17	37009953	37009953	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:37009953C>G	uc002hqx.1	-	1	101	c.11G>C	c.(10-12)CGA>CCA	p.R4P	RPL23_uc002hqw.1_5'Flank|RPL23_uc002hqy.1_Missense_Mutation_p.R4P|SNORA21_uc002hqz.1_5'Flank	NM_000978	NP_000969	P62829	RL23_HUMAN	ribosomal protein L23	4					endocrine pancreas development|ribosomal protein import into nucleus|translational elongation|translational termination|viral transcription	cytosol|ribosome	protein binding|structural constituent of ribosome				0						AACCTCACCTCGCTTCGACAT	0.562		NA											5	26					0	0	0	0
KRT25	147183	broad.mit.edu	37	17	38910665	38910665	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:38910665C>T	uc002hve.2	-	2	546	c.485G>A	c.(484-486)AGG>AAG	p.R162K		NM_181534	NP_853512	Q7Z3Z0	K1C25_HUMAN	keratin 25	162	Rod.|Coil 1B.					cytoplasm|intermediate filament	structural molecule activity			ovary(2)	2		Breast(137;0.00526)				AGCTGTAAGCCTGGCATTATC	0.393		NA											27	73					0	0	0	0
KRT12	3859	broad.mit.edu	37	17	39019473	39019473	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:39019473C>A	uc002hvk.2	-	6	1242	c.1218G>T	c.(1216-1218)GAG>GAT	p.E406D		NM_000223	NP_000214	Q99456	K1C12_HUMAN	keratin 12	406	Rod.|Coil 2.				visual perception	intermediate filament	structural molecule activity			ovary(1)	1		Breast(137;0.000301)				CGTTCTGGCGCTCTGCGTCCG	0.672		NA											18	26					3.33e-07	5.55e-07	1	0
KRTAP1-3	81850	broad.mit.edu	37	17	39190992	39190992	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:39190992T>C	uc002hvv.2	-	1	116	c.82A>G	c.(82-84)AGC>GGC	p.S28G		NM_030966	NP_112228	Q8IUG1	KRA13_HUMAN	keratin associated protein 1-3	28						extracellular region|keratin filament	structural constituent of epidermis				0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			TCACAGCAGCTTGGCTGGCAG	0.597		NA											34	57					0	0	0	0
KRT33B	3884	broad.mit.edu	37	17	39521745	39521745	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:39521745G>T	uc002hwl.2	-	4	694	c.649C>A	c.(649-651)CCC>ACC	p.P217T		NM_002279	NP_002270	Q14525	KT33B_HUMAN	type I hair keratin 3B	217	Linker 12.|Rod.					intermediate filament	protein binding|structural molecule activity				0		Breast(137;0.000496)				TCCACAGCGGGAGCAGCGTCC	0.557		NA											17	49					4.15e-12	7.62e-12	1	0
KRT34	3885	broad.mit.edu	37	17	39535393	39535393	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:39535393C>A	uc002hwm.2	-	6	1050	c.1038G>T	c.(1036-1038)GAG>GAT	p.E346D		NM_021013	NP_066293	O76011	KRT34_HUMAN	keratin 34	346	Rod.|Coil 2.				epidermis development	intermediate filament	protein binding|structural molecule activity			central_nervous_system(1)	1		Breast(137;0.000496)				TGTAGTGGGCCTCGCTCTCCG	0.577		NA											39	65					3.66e-28	7.66e-28	1	0
FAM134C	162427	broad.mit.edu	37	17	40734205	40734205	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:40734205G>C	uc002ial.2	-	9	1130	c.1027C>G	c.(1027-1029)CTG>GTG	p.L343V	FAM134C_uc010wgq.1_Missense_Mutation_p.L143V|FAM134C_uc002iam.1_Missense_Mutation_p.L143V|FAM134C_uc010cyk.1_Missense_Mutation_p.L246V	NM_178126	NP_835227	Q86VR2	F134C_HUMAN	hypothetical protein LOC162427	343						integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.134)		TCATCATCCAGGCCAGCAGGA	0.567		NA											39	90					0	0	0	0
RUNDC1	146923	broad.mit.edu	37	17	41133041	41133041	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:41133041G>C	uc002ici.1	+	1	460	c.448G>C	c.(448-450)GAG>CAG	p.E150Q	AARSD1_uc002icd.2_5'Flank|AARSD1_uc002ice.2_5'Flank|AARSD1_uc002icf.2_5'Flank|AARSD1_uc010whg.1_5'Flank|AARSD1_uc002icg.2_5'Flank|AARSD1_uc002ich.2_5'Flank|AARSD1_uc010whh.1_5'Flank|RUNDC1_uc010whi.1_5'UTR	NM_173079	NP_775102	Q96C34	RUND1_HUMAN	RUN domain containing 1	150											0		Breast(137;0.00499)		BRCA - Breast invasive adenocarcinoma(366;0.161)		CGCCAGCGATGAGGGCGATGG	0.697		NA											4	6					0	0	0	0
ADAM11	4185	broad.mit.edu	37	17	42854579	42854579	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:42854579C>T	uc002ihh.2	+	21	1727	c.1727C>T	c.(1726-1728)ACG>ATG	p.T576M	ADAM11_uc010wjd.1_Missense_Mutation_p.T376M|ADAM11_uc002ihi.2_5'Flank	NM_002390	NP_002381	O75078	ADA11_HUMAN	ADAM metallopeptidase domain 11 preproprotein	576	Cys-rich.|Extracellular (Potential).				integrin-mediated signaling pathway|proteolysis	integral to membrane|plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			pancreas(1)	1		Prostate(33;0.0959)				GTGGAGGGGACGGAGCGTGGG	0.647		NA											9	35					0	0	0	0
EFTUD2	9343	broad.mit.edu	37	17	42931930	42931931	+	Missense_Mutation	DNP	GG	GG	AA			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:42931930_42931931GG>AA	uc002ihn.2	-	22	2513_2514	c.2252_2253CC>TT	c.(2251-2253)CCC>CTT	p.P751L	EFTUD2_uc010wje.1_Missense_Mutation_p.P716L|EFTUD2_uc010wjf.1_Missense_Mutation_p.P741L	NM_004247	NP_004238	Q15029	U5S1_HUMAN	elongation factor Tu GTP binding domain	751						Cajal body|catalytic step 2 spliceosome|cytoplasm|nuclear speck	GTP binding|GTPase activity|protein binding			ovary(1)	1		Prostate(33;0.109)				GTACCTCAGAGGGCAGAGTATC	0.52		NA											26	101					0	0	0	0
UTP18	51096	broad.mit.edu	37	17	49353297	49353297	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:49353297C>A	uc002its.2	+	6	831	c.782C>A	c.(781-783)CCC>CAC	p.P261H		NM_016001	NP_057085	Q9Y5J1	UTP18_HUMAN	UTP18, small subunit processome component	261	WD 1.				rRNA processing	nucleolus					0			BRCA - Breast invasive adenocarcinoma(22;2.09e-07)			CAGTTCCATCCCGGTGCACAG	0.383		NA											14	21					2.32e-09	4.08e-09	1	0
MSI2	124540	broad.mit.edu	37	17	55607074	55607074	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:55607074A>G	uc002iuz.1	+	7	616	c.443A>G	c.(442-444)AAC>AGC	p.N148S	MSI2_uc010wnm.1_Missense_Mutation_p.N126S|MSI2_uc002iva.2_Missense_Mutation_p.N144S	NM_138962	NP_620412	Q96DH6	MSI2H_HUMAN	musashi 2 isoform a	148	RRM 2.					cytoplasm	nucleotide binding|RNA binding	p.N144S(1)		central_nervous_system(1)|pancreas(1)	2	Breast(9;1.78e-08)			GBM - Glioblastoma multiforme(1;0.0025)		AAAACTACCAACAGGCACAGA	0.308		NA	T	HOXA9	CML								13	30					0	0	0	0
C17orf47	284083	broad.mit.edu	37	17	56619276	56619276	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:56619276C>A	uc002iwq.1	-	2	1749	c.1613G>T	c.(1612-1614)TGC>TTC	p.C538F	SEPT4_uc010wnx.1_5'Flank|SEPT4_uc010wny.1_5'Flank	NM_001038704	NP_001033793	Q8NEP4	CQ047_HUMAN	hypothetical protein LOC284083	538										breast(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GAGGGAAAAGCACAGACCTTT	0.493		NA											46	102					2.01e-17	3.98e-17	1	0
CCDC47	57003	broad.mit.edu	37	17	61833679	61833679	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:61833679C>A	uc002jbs.3	-	8	1205	c.869G>T	c.(868-870)GGA>GTA	p.G290V	CCDC47_uc010ddx.2_Missense_Mutation_p.G290V|CCDC47_uc002jbt.2_Missense_Mutation_p.G290V	NM_020198	NP_064583	Q96A33	CCD47_HUMAN	coiled-coil domain containing 47 precursor	290						integral to membrane	protein binding				0						ATACTTTGCTCCAGACTTAGG	0.408		NA											21	49					2.38e-13	4.46e-13	1	0
CCDC47	57003	broad.mit.edu	37	17	61843413	61843413	+	Silent	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:61843413T>C	uc002jbs.3	-	2	459	c.123A>G	c.(121-123)GAA>GAG	p.E41E	CCDC47_uc010ddx.2_Silent_p.E41E|CCDC47_uc002jbt.2_Silent_p.E41E	NM_020198	NP_064583	Q96A33	CCD47_HUMAN	coiled-coil domain containing 47 precursor	41						integral to membrane	protein binding				0						CATCCTCAAATTCAGCGAAGT	0.443		NA											59	129					0	0	0	0
RGS9	8787	broad.mit.edu	37	17	63206682	63206682	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:63206682G>T	uc002jfe.2	+	17	1476	c.1366G>T	c.(1366-1368)GCC>TCC	p.A456S	RGS9_uc010dem.2_Missense_Mutation_p.A453S|RGS9_uc002jfd.2_Missense_Mutation_p.A453S|RGS9_uc002jff.2_RNA|RGS9_uc002jfg.2_Missense_Mutation_p.A227S	NM_003835	NP_003826	O75916	RGS9_HUMAN	regulator of G-protein signaling 9 isoform 1	456					intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			ovary(2)|skin(2)	4						GGAAGAGGAAGCCAAGGCCCG	0.567		NA											28	69					1.55e-18	3.12e-18	1	0
HELZ	9931	broad.mit.edu	37	17	65119097	65119097	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:65119097C>T	uc010wqk.1	-	26	3809	c.3622G>A	c.(3622-3624)GTG>ATG	p.V1208M	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Missense_Mutation_p.V1207M	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					GGTAAAGGCACCGACATAACT	0.378		NA											11	47					0	0	0	0
HELZ	9931	broad.mit.edu	37	17	65162623	65162623	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:65162623C>T	uc010wqk.1	-	15	2053	c.1866G>A	c.(1864-1866)ATG>ATA	p.M622I	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Missense_Mutation_p.M622I	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					TGGTGGGAGTCATACTGATGT	0.363		NA											20	44					0	0	0	0
NOL11	25926	broad.mit.edu	37	17	65717512	65717512	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:65717512A>G	uc002jgd.1	+	4	334	c.331A>G	c.(331-333)AGG>GGG	p.R111G	NOL11_uc010wql.1_Translation_Start_Site|NOL11_uc010deu.1_Translation_Start_Site	NM_015462	NP_056277	Q9H8H0	NOL11_HUMAN	nucleolar protein 11	111						nucleolus					0	all_cancers(12;1.54e-10)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0518)|COAD - Colon adenocarcinoma(4;0.0977)|LUSC - Lung squamous cell carcinoma(166;0.24)			AGAAGTATATAGGATACTTTC	0.358		NA											16	61					0	0	0	0
ABCA8	10351	broad.mit.edu	37	17	66871844	66871844	+	Silent	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:66871844C>G	uc002jhp.2	-	34	4460	c.4281G>C	c.(4279-4281)ACG>ACC	p.T1427T	ABCA8_uc002jhq.2_Silent_p.T1467T|ABCA8_uc010wqq.1_Silent_p.T1462T	NM_007168	NP_009099	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A member 8	1427	ABC transporter 2.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3	Breast(10;4.56e-13)					CACCCCTTTCCGTGTTTCTAA	0.488		NA											12	32					0	0	0	0
DNAI2	64446	broad.mit.edu	37	17	72301505	72301505	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:72301505A>T	uc002jkf.2	+	9	1234	c.1135A>T	c.(1135-1137)AAC>TAC	p.N379Y	DNAI2_uc002jkg.2_RNA|DNAI2_uc010dfp.2_RNA|uc002jkh.1_3'UTR|DNAI2_uc002jki.2_RNA	NM_023036	NP_075462	Q9GZS0	DNAI2_HUMAN	dynein, axonemal, intermediate polypeptide 2	379	WD 4.				cilium assembly	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	microtubule motor activity			ovary(2)|central_nervous_system(1)	3						CTACCCGAAGAACTTCCTGAC	0.577		NA							Kartagener_syndrome				34	36					0	0	0	0
LLGL2	3993	broad.mit.edu	37	17	73569302	73569302	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:73569302A>G	uc002joh.2	+	20	2822	c.2668A>G	c.(2668-2670)ATC>GTC	p.I890V	LLGL2_uc002joi.2_Missense_Mutation_p.I890V|LLGL2_uc010dgg.1_Missense_Mutation_p.I890V|LLGL2_uc002joj.2_Missense_Mutation_p.I879V|LLGL2_uc010wsd.1_Missense_Mutation_p.I517V	NM_001031803	NP_001026973	Q6P1M3	L2GL2_HUMAN	lethal giant larvae homolog 2 isoform c	890					cell cycle|cell division|exocytosis|regulation of establishment or maintenance of cell polarity	cytoplasm|intracellular membrane-bounded organelle	PDZ domain binding			ovary(2)	2	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;1.8e-07)|Epithelial(20;1.38e-06)|Lung(188;0.0696)|LUSC - Lung squamous cell carcinoma(166;0.112)			CTACAGCTGCATCCGCCGGGA	0.662		NA											28	59					0	0	0	0
AFMID	125061	broad.mit.edu	37	17	76200969	76200969	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:76200969A>G	uc002jva.3	+	6	470	c.455A>G	c.(454-456)TAT>TGT	p.Y152C	AFMID_uc002jvb.3_Intron|AFMID_uc002juz.3_Missense_Mutation_p.Y152C	NM_001010982	NP_001010982	Q63HM1	AFMID_HUMAN	arylformamidase isoform 1	152						cytosol|nucleus	arylformamidase activity			large_intestine(1)|pancreas(1)	2			BRCA - Breast invasive adenocarcinoma(99;0.00269)|OV - Ovarian serous cystadenocarcinoma(97;0.134)			CAGAAGCGGTATCCAAGCAAC	0.557		NA											11	26					0	0	0	0
AZI1	22994	broad.mit.edu	37	17	79176070	79176070	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:79176070C>A	uc002jzp.1	-	7	958	c.758G>T	c.(757-759)CGG>CTG	p.R253L	AZI1_uc002jzn.1_Missense_Mutation_p.R253L|AZI1_uc002jzo.1_Missense_Mutation_p.R253L|AZI1_uc010wum.1_Missense_Mutation_p.R253L	NM_014984	NP_055799	Q9UPN4	AZI1_HUMAN	5-azacytidine induced 1 isoform a	253					cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centrosome|cytosol|intracellular membrane-bounded organelle				central_nervous_system(2)|large_intestine(1)|ovary(1)	4	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			CACCTCCTTCCGCCTGGGCAA	0.652		NA											16	48					1.15e-07	1.93e-07	1	0
FN3K	64122	broad.mit.edu	37	17	80699208	80699208	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:80699208A>T	uc010wvs.1	+	4	468	c.407A>T	c.(406-408)GAG>GTG	p.E136V	FN3K_uc002kfw.1_Missense_Mutation_p.E91V	NM_022158	NP_071441	Q9H479	FN3K_HUMAN	fructosamine 3 kinase	136					fructoselysine metabolic process		fructosamine-3-kinase activity				0	Breast(20;0.000523)|all_neural(118;0.0952)		BRCA - Breast invasive adenocarcinoma(99;0.0344)|OV - Ovarian serous cystadenocarcinoma(97;0.061)			GAGGGTGCTGAGCCTCAGTAT	0.552		NA											8	9					0	0	0	0
TBCD	6904	broad.mit.edu	37	17	80885196	80885196	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:80885196C>T	uc002kfz.2	+	29	2736	c.2606C>T	c.(2605-2607)ACC>ATC	p.T869I	TBCD_uc002kfy.1_Missense_Mutation_p.T869I|TBCD_uc002kgb.1_Missense_Mutation_p.T194I|TBCD_uc002kgc.2_Missense_Mutation_p.T14I|TBCD_uc002kgd.2_5'Flank	NM_005993	NP_005984	Q9BTW9	TBCD_HUMAN	beta-tubulin cofactor D	869					'de novo' posttranslational protein folding|adherens junction assembly|negative regulation of cell-substrate adhesion|negative regulation of microtubule polymerization|post-chaperonin tubulin folding pathway|tight junction assembly	adherens junction|cytoplasm|lateral plasma membrane|microtubule|tight junction	beta-tubulin binding|chaperone binding|GTPase activator activity				0	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0266)|all_epithelial(8;0.0696)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.18)			GACGTGGGCACCTGGTACGTA	0.572		NA											6	15					0	0	0	0
CETN1	1068	broad.mit.edu	37	18	580859	580859	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:580859C>T	uc002kko.1	+	1	493	c.451C>T	c.(451-453)CGG>TGG	p.R151W		NM_004066	NP_004057	Q12798	CETN1_HUMAN	centrin 1	151	2 (Probable).|EF-hand 4.				cell division|mitosis	spindle pole	ATP binding|ATP-dependent helicase activity|calcium ion binding|nucleic acid binding			upper_aerodigestive_tract(1)|ovary(1)	2						CGAAGCTGATCGGGATGGGGA	0.547		NA											46	173					0	0	0	0
TMEM200C	645369	broad.mit.edu	37	18	5891787	5891787	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:5891787C>T	uc002kmx.1	-	1	317	c.276G>A	c.(274-276)GCG>GCA	p.A92A		NM_001080209	NP_001073678	A6NKL6	T200C_HUMAN	transmembrane protein 200C	92						integral to membrane					0						GGCTGCTGCCCGCAGGCGGCA	0.672		NA											12	131					0	0	0	0
ARHGAP28	79822	broad.mit.edu	37	18	6876197	6876197	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:6876197C>A	uc010wzi.1	+	9	987	c.749C>A	c.(748-750)GCT>GAT	p.A250D	ARHGAP28_uc002knc.2_Missense_Mutation_p.A375D|ARHGAP28_uc002knd.2_Missense_Mutation_p.A268D|ARHGAP28_uc002kne.2_Missense_Mutation_p.A268D|ARHGAP28_uc002knf.2_Missense_Mutation_p.A259D			B4DXL2	B4DXL2_HUMAN	SubName: Full=Putative uncharacterized protein ARHGAP28;	250					signal transduction	intracellular				pancreas(1)	1		Colorectal(10;0.168)				GGATGTACTGCTAAAGTCAAG	0.388		NA											65	63					5.26e-25	1.1e-24	1	0
LAMA1	284217	broad.mit.edu	37	18	7024446	7024446	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:7024446G>A	uc002knm.2	-	18	2516	c.2422C>T	c.(2422-2424)CTC>TTC	p.L808F	LAMA1_uc010wzj.1_Missense_Mutation_p.L284F	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	808	Laminin EGF-like 7.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCATCATTGAGGTGGCAGGTG	0.438		NA											8	73					0	0	0	0
PTPRM	5797	broad.mit.edu	37	18	8379247	8379247	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:8379247G>T	uc002knn.3	+	26	4159	c.3656G>T	c.(3655-3657)TGC>TTC	p.C1219F	PTPRM_uc010dkv.2_Missense_Mutation_p.C1232F|PTPRM_uc010wzl.1_Missense_Mutation_p.C1006F	NM_002845	NP_002836	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	1219	Tyrosine-protein phosphatase 2.|Cytoplasmic (Potential).				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			lung(3)|ovary(2)|central_nervous_system(1)	6		Colorectal(10;0.234)				AAAAACCGGTGCATGGACATC	0.567		NA											35	153					1.08e-12	2e-12	1	0
TXNDC2	84203	broad.mit.edu	37	18	9887082	9887082	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:9887082C>G	uc002koi.3	+	2	1055	c.606C>G	c.(604-606)ATC>ATG	p.I202M	TXNDC2_uc010wzq.1_Intron|TXNDC2_uc002koh.3_Missense_Mutation_p.I135M	NM_001098529	NP_001091999	Q86VQ3	TXND2_HUMAN	thioredoxin domain-containing 2 isoform 2	202	22 X 15 AA approximate tandem repeat of Q-P-K-X-G-D-I-P-K-S-[PS]-E-[KE]-X-I.|6.				cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	cytoplasm	electron carrier activity|nutrient reservoir activity|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			ovary(1)|pancreas(1)	2						AAGAAGCCATCCAGCCCAAAG	0.577		NA											55	534					0	0	0	0
MC5R	4161	broad.mit.edu	37	18	13826509	13826509	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:13826509G>A	uc010xaf.1	+	1	745	c.745G>A	c.(745-747)GTG>ATG	p.V249M		NM_005913	NP_005904	P33032	MC5R_HUMAN	melanocortin 5 receptor	249	Helical; Name=6; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocortin receptor activity|protein binding			ovary(3)|lung(2)|breast(1)	6						CGTGTTTACCGTGTGCTGGGC	0.587		NA											50	417					0	0	0	0
ZNF519	162655	broad.mit.edu	37	18	14105881	14105881	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:14105881G>A	uc002kst.1	-	3	811	c.658C>T	c.(658-660)CCA>TCA	p.P220S	ZNF519_uc002ksq.1_Intron|ZNF519_uc002ksr.1_Intron|ZNF519_uc010dlm.1_Intron	NM_145287	NP_660330	Q8TB69	ZN519_HUMAN	zinc finger protein 519	220					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TTTGAGAATGGGTCAGAAGTT	0.299		NA											15	167					0	0	0	0
ANKRD30B	374860	broad.mit.edu	37	18	14822494	14822494	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:14822494A>T	uc010dlo.2	+	25	2477	c.2297A>T	c.(2296-2298)AAA>ATA	p.K766I		NM_001145029	NP_001138501	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	851										ovary(1)|skin(1)	2						TCTCCTGATAAAGATGGTCTT	0.274		NA											7	65					0	0	0	0
ROCK1	6093	broad.mit.edu	37	18	18572799	18572799	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:18572799G>A	uc002kte.2	-	17	2926	c.1985C>T	c.(1984-1986)TCA>TTA	p.S662L		NM_005406	NP_005397	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein	662	Glu-rich.|Interaction with FHOD1.				actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			lung(2)|breast(2)|central_nervous_system(1)	5	Melanoma(1;0.165)					TACCTTTTCTGAGTGATTAAG	0.303		NA											20	20					0	0	0	0
ASXL3	80816	broad.mit.edu	37	18	31323688	31323688	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:31323688C>A	uc010dmg.1	+	12	3931	c.3876C>A	c.(3874-3876)TGC>TGA	p.C1292*	ASXL3_uc002kxq.2_Nonsense_Mutation_p.C999*	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	1292	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						ACACTCCATGCATAGCCATTA	0.393		NA											68	53					1.72e-30	3.62e-30	1	0
SLC14A2	8170	broad.mit.edu	37	18	43253684	43253684	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:43253684T>A	uc010dnj.2	+	19	2735	c.2414T>A	c.(2413-2415)TTC>TAC	p.F805Y	SLC14A2_uc002lbe.2_Missense_Mutation_p.F805Y	NM_007163	NP_009094	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter),	805	Helical; (Potential).					apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)|skin(1)	4						TCCATCTACTTCGGCCTGTGT	0.587		NA											41	32					0	0	0	0
TCEB3B	51224	broad.mit.edu	37	18	44560992	44560992	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:44560992G>T	uc002lcr.1	-	1	997	c.644C>A	c.(643-645)CCC>CAC	p.P215H	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_016427	NP_057511	Q8IYF1	ELOA2_HUMAN	elongin A2	215					regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			ovary(2)|large_intestine(1)|pancreas(1)	4						TTTCCCCTGGGGTTGGCCCTG	0.662		NA											22	9					2.01e-23	4.16e-23	1	0
ME2	4200	broad.mit.edu	37	18	48439273	48439273	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:48439273G>T	uc002ley.2	+	4	601	c.345G>T	c.(343-345)ACG>ACT	p.T115T	ME2_uc010dpd.2_Silent_p.T115T	NM_002396	NP_002387	P23368	MAOM_HUMAN	malic enzyme 2, NAD(+)-dependent, mitochondrial	115					malate metabolic process	mitochondrial matrix	electron carrier activity|malate dehydrogenase (decarboxylating) activity|malate dehydrogenase (oxaloacetate-decarboxylating) activity|metal ion binding|NAD binding				0		Colorectal(6;0.0273)|all_epithelial(6;0.118)		Colorectal(21;0.0313)|READ - Rectum adenocarcinoma(32;0.105)|STAD - Stomach adenocarcinoma(97;0.184)	NADH(DB00157)	ATACACCGACGGTTGGTCTTG	0.323		NA											66	54					1.18e-34	2.5e-34	1	0
DCC	1630	broad.mit.edu	37	18	51013297	51013297	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:51013297G>T	uc002lfe.1	+	26	4454	c.3867G>T	c.(3865-3867)GTG>GTT	p.V1289V	DCC_uc010dpf.1_Silent_p.V924V	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	1289	Cytoplasmic (Potential).				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		CACTCTCAGTGGACCGAGGTT	0.473		NA											42	35					2.27e-22	4.66e-22	1	0
CDH20	28316	broad.mit.edu	37	18	59203814	59203814	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:59203814C>T	uc010dps.1	+	7	1372	c.1360C>T	c.(1360-1362)CGG>TGG	p.R454W	CDH20_uc002lif.2_Missense_Mutation_p.R448W	NM_031891	NP_114097	Q9HBT6	CAD20_HUMAN	cadherin 20, type 2 preproprotein	454	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|ovary(1)|pancreas(1)	5		Colorectal(73;0.186)				ACCCCTAGACCGGGAAGAATT	0.408		NA											52	55					0	0	0	0
CD226	10666	broad.mit.edu	37	18	67562961	67562961	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:67562961C>A	uc010dqo.2	-	3	1150	c.703G>T	c.(703-705)GTG>TTG	p.V235L	CD226_uc002lkm.3_Missense_Mutation_p.V235L	NM_006566	NP_006557	Q15762	CD226_HUMAN	CD226 molecule precursor	235	Ig-like C2-type 2.|Extracellular (Potential).				cell adhesion|cell recognition|positive regulation of Fc receptor mediated stimulatory signaling pathway|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	cell surface|integral to plasma membrane|membrane raft	cell adhesion molecule binding|integrin binding|protein kinase binding|receptor activity				0		Esophageal squamous(42;0.129)				AATCTCATCACGAAGGTTTCG	0.532		NA											84	72					1.29e-55	2.76e-55	1	0
NETO1	81832	broad.mit.edu	37	18	70417315	70417315	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:70417315T>A	uc002lkw.2	-	9	1807	c.1523A>T	c.(1522-1524)CAC>CTC	p.H508L	NETO1_uc002lkx.1_Missense_Mutation_p.H507L|NETO1_uc002lky.1_Missense_Mutation_p.H508L	NM_138966	NP_620416	Q8TDF5	NETO1_HUMAN	neuropilin- and tolloid-like protein 1 isoform 3	508	Cytoplasmic (Potential).				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			ovary(2)|skin(2)	4		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		GGCTTTATCGTGTCTGGACAG	0.438		NA											26	25					0	0	0	0
CDC34	997	broad.mit.edu	37	19	541375	541375	+	Silent	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:541375T>C	uc002lov.2	+	5	733	c.534T>C	c.(532-534)CGT>CGC	p.R178R	GZMM_uc002low.1_5'Flank	NM_004359	NP_004350	P49427	UB2R1_HUMAN	ubiquitin-conjugating enzyme Cdc34	178					DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|negative regulation of cAMP-mediated signaling|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination	cytoplasm|nucleus	ATP binding|protein binding|ubiquitin-protein ligase activity				0		all_cancers(10;1.94e-35)|all_epithelial(18;5.94e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACGCGGAGCGTGACGGCGTGA	0.706		NA											6	11					0	0	0	0
PALM	5064	broad.mit.edu	37	19	746513	746513	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:746513C>A	uc002lpm.1	+	9	1057	c.863C>A	c.(862-864)CCG>CAG	p.P288Q	PALM_uc002lpn.1_Missense_Mutation_p.P244Q|PALM_uc010xfu.1_Missense_Mutation_p.P153Q	NM_002579	NP_002570	O75781	PALM_HUMAN	paralemmin isoform 1	288					cellular component movement|negative regulation of adenylate cyclase activity|negative regulation of dopamine receptor signaling pathway|positive regulation of filopodium assembly|regulation of cell shape	cytoplasmic membrane-bounded vesicle|filopodium membrane|integral to plasma membrane					0		all_epithelial(18;2.19e-21)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)|Lung(535;0.201)		TCCGGCCCGCCGGGGATCCAG	0.697		NA											10	40					3.86e-05	6e-05	1	0
DIRAS1	148252	broad.mit.edu	37	19	2717513	2717513	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:2717513C>T	uc002lwf.3	-	2	450	c.292G>A	c.(292-294)GGG>AGG	p.G98R		NM_145173	NP_660156	O95057	DIRA1_HUMAN	DIRAS family, GTP-binding RAS-like 1	98					small GTPase mediated signal transduction	intracellular|plasma membrane	GTP binding|GTPase activity			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TAGATGGGCCCCAGCTCCTCC	0.627		NA											17	26					0	0	0	0
TLE2	7089	broad.mit.edu	37	19	3015720	3015720	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:3015720C>G	uc002lww.2	-	9	872	c.609G>C	c.(607-609)GAG>GAC	p.E203D	TLE2_uc010xhb.1_5'UTR|TLE2_uc010dth.2_Missense_Mutation_p.E204D|TLE2_uc010xhc.1_Missense_Mutation_p.E81D|TLE2_uc010dti.2_Missense_Mutation_p.E217D|TLE2_uc010xhd.1_Missense_Mutation_p.E111D	NM_003260	NP_003251	Q04725	TLE2_HUMAN	transducin-like enhancer protein 2 isoform 1	203	CCN domain.				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription corepressor activity				0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCGGTCGCTCCTCCTCCACGA	0.632		NA											8	12					0	0	0	0
PIP5K1C	23396	broad.mit.edu	37	19	3653452	3653452	+	Missense_Mutation	SNP	C	C	G	rs121908315		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:3653452C>G	uc002lyj.1	-	7	814	c.757G>C	c.(757-759)GAC>CAC	p.D253H	PIP5K1C_uc010xhq.1_Missense_Mutation_p.D253H|PIP5K1C_uc010xhr.1_Missense_Mutation_p.D253H	NM_012398	NP_036530	O60331	PI51C_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	253	PIPK.		D -> N (in LCCS3; loss of activity).		axon guidance	cytosol|plasma membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding			stomach(2)|skin(2)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.95e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0026)|STAD - Stomach adenocarcinoma(1328;0.183)		CCCTTGAGGTCGAACTTGAGG	0.587		NA											21	61					0	0	0	0
ZBTB7A	51341	broad.mit.edu	37	19	4054160	4054160	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:4054160G>T	uc002lzh.2	-	2	1146	c.1071C>A	c.(1069-1071)AGC>AGA	p.S357R	ZBTB7A_uc002lzi.2_Missense_Mutation_p.S357R	NM_015898	NP_056982	O95365	ZBT7A_HUMAN	zinc finger and BTB domain containing 7A	357					cell differentiation|multicellular organismal development|transcription, DNA-dependent	nucleus	DNA binding|histone acetyltransferase binding|zinc ion binding			pancreas(1)|skin(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.014)|STAD - Stomach adenocarcinoma(1328;0.18)		CGTGGGCGCCGCTGAAGTACT	0.537		NA											20	44					7.42e-09	1.28e-08	1	0
ZBTB7A	51341	broad.mit.edu	37	19	4054266	4054266	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:4054266T>A	uc002lzh.2	-	2	1040	c.965A>T	c.(964-966)CAG>CTG	p.Q322L	ZBTB7A_uc002lzi.2_Missense_Mutation_p.Q322L	NM_015898	NP_056982	O95365	ZBT7A_HUMAN	zinc finger and BTB domain containing 7A	322					cell differentiation|multicellular organismal development|transcription, DNA-dependent	nucleus	DNA binding|histone acetyltransferase binding|zinc ion binding			pancreas(1)|skin(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.014)|STAD - Stomach adenocarcinoma(1328;0.18)		TGACATCATCTGCTGCAGCAG	0.602		NA											4	15					0	0	0	0
ARRDC5	645432	broad.mit.edu	37	19	4891178	4891178	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:4891178C>A	uc002mbm.2	-	3	909	c.909G>T	c.(907-909)TGG>TGT	p.W303C		NM_001080523	NP_001073992	A6NEK1	ARRD5_HUMAN	arrestin domain containing 5	303					signal transduction						0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0257)		TGGTCAGGGACCAGGGCAGGT	0.607		NA											52	132					2.3e-20	4.68e-20	1	0
KDM4B	23030	broad.mit.edu	37	19	5082396	5082396	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:5082396G>T	uc002mbq.3	+	9	1025	c.799G>T	c.(799-801)GAA>TAA	p.E267*	KDM4B_uc010xil.1_Nonsense_Mutation_p.E267*|KDM4B_uc010xim.1_Nonsense_Mutation_p.E267*|KDM4B_uc002mbr.3_Nonsense_Mutation_p.E25*	NM_015015	NP_055830	O94953	KDM4B_HUMAN	jumonji domain containing 2B	267	JmjC.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			lung(1)	1						GGAGGCCGGGGAATTCATGAT	0.597		NA											11	23					9.7e-10	1.72e-09	1	0
C3	718	broad.mit.edu	37	19	6686804	6686804	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:6686804C>G	uc002mfm.2	-	28	3661	c.3599G>C	c.(3598-3600)GGC>GCC	p.G1200A	C3_uc002mfl.2_5'UTR	NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor	1200					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		CTTCAGCCTGCCCATCTGGGC	0.542		NA											71	163					0	0	0	0
TIMM44	10469	broad.mit.edu	37	19	7999066	7999066	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:7999066C>A	uc002miz.2	-	5	453	c.451G>T	c.(451-453)GAA>TAA	p.E151*	TIMM44_uc002mja.2_5'UTR|TIMM44_uc010dvx.1_RNA	NM_006351	NP_006342	O43615	TIM44_HUMAN	translocase of inner mitochondrial membrane 44	151					protein targeting to mitochondrion	mitochondrial inner membrane presequence translocase complex|mitochondrial matrix	ATP binding|P-P-bond-hydrolysis-driven protein transmembrane transporter activity			ovary(1)	1						TTGGCTGCTTCCTCCACGCCC	0.622		NA											32	103					9.94e-08	1.68e-07	1	0
FBN3	84467	broad.mit.edu	37	19	8206823	8206824	+	Splice_Site	DNP	CC	CC	AA			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:8206823_8206824CC>AA	uc002mjf.2	-	6	760	c.739_splice	c.e6+1	p.D247_splice		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor							proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						CCACTATTCACCTTGGCAGGCC	0.634		NA											12	48					0	0	0	0
MYO1F	4542	broad.mit.edu	37	19	8587264	8587264	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:8587264C>T	uc002mkg.2	-	27	3331	c.3217G>A	c.(3217-3219)GAA>AAA	p.E1073K		NM_012335	NP_036467	O00160	MYO1F_HUMAN	myosin IF	1073	SH3.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(1)	3						CACACACCTTCCATGAGGATC	0.453		NA											12	27					0	0	0	0
MUC16	94025	broad.mit.edu	37	19	9015728	9015728	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:9015728C>A	uc002mkp.2	-	29	38299	c.38095G>T	c.(38095-38097)GTG>TTG	p.V12699L	MUC16_uc010xki.1_5'Flank	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12701	SEA 5.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTGAACGGCACCAGGAGAGGG	0.458		NA											35	113					0.000109025	0.000166631	1	0
MUC16	94025	broad.mit.edu	37	19	9059286	9059286	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:9059286G>A	uc002mkp.2	-	3	28364	c.28160C>T	c.(28159-28161)TCA>TTA	p.S9387L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	9389	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGCTGTGCTTGATGAGTCCAA	0.527		NA											35	103					0	0	0	0
MUC16	94025	broad.mit.edu	37	19	9059658	9059658	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:9059658G>C	uc002mkp.2	-	3	27992	c.27788C>G	c.(27787-27789)ACA>AGA	p.T9263R		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	9265	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GAGAACATTTGTATCTCCTGT	0.473		NA											29	90					0	0	0	0
MUC16	94025	broad.mit.edu	37	19	9071927	9071927	+	Silent	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:9071927A>G	uc002mkp.2	-	3	15723	c.15519T>C	c.(15517-15519)GGT>GGC	p.G5173G		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	5175	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TCTCAGAGGAACCATGCACTG	0.498		NA											70	242					0	0	0	0
MUC16	94025	broad.mit.edu	37	19	9075894	9075894	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:9075894T>A	uc002mkp.2	-	3	11756	c.11552A>T	c.(11551-11553)CAG>CTG	p.Q3851L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	3852	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CCCTTGTCTCTGAAAAGTTGC	0.502		NA											34	67					0	0	0	0
TYK2	7297	broad.mit.edu	37	19	10475629	10475629	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:10475629C>T	uc002moc.3	-	8	1485	c.1107G>A	c.(1105-1107)CCG>CCA	p.P369P	TYK2_uc010dxe.2_Silent_p.P184P|TYK2_uc002mod.2_Silent_p.P369P	NM_003331	NP_003322	P29597	TYK2_HUMAN	tyrosine kinase 2	369	FERM.				intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			lung(5)|large_intestine(2)|ovary(1)|breast(1)	9			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)			GTGGCTCCCGCGGCCTGTCTG	0.617		NA											20	43					0	0	0	0
SMARCA4	6597	broad.mit.edu	37	19	11144853	11144853	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:11144853G>T	uc002mqf.3	+	28	4212	c.3928G>T	c.(3928-3930)GAG>TAG	p.E1310*	SMARCA4_uc010dxp.2_Nonsense_Mutation_p.E1310*|SMARCA4_uc010dxo.2_Nonsense_Mutation_p.E1310*|SMARCA4_uc010dxq.2_Nonsense_Mutation_p.E1277*|SMARCA4_uc010dxr.2_Nonsense_Mutation_p.E1277*|SMARCA4_uc002mqj.3_Nonsense_Mutation_p.E1277*|SMARCA4_uc010dxs.2_Nonsense_Mutation_p.E1277*|SMARCA4_uc010dxt.1_Nonsense_Mutation_p.E497*|SMARCA4_uc002mqh.3_Nonsense_Mutation_p.E400*|SMARCA4_uc002mqi.1_Nonsense_Mutation_p.E480*	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	1310					chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.E1310*(2)		lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				CGCCCGGCACGAGGAGGAGTT	0.597		NA	F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				24	44					2.22e-12	4.09e-12	1	0
ZNF625	90589	broad.mit.edu	37	19	12256682	12256682	+	Silent	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:12256682T>A	uc002mth.2	-	4	701	c.351A>T	c.(349-351)ATA>ATT	p.I117I	ZNF20_uc002mtg.1_Intron|ZNF625_uc010dyn.1_RNA|ZNF625_uc010dyo.1_Silent_p.I151I	NM_145233	NP_660276	Q96I27	ZN625_HUMAN	zinc finger protein 625	117	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CACTGTGCATTATCCTGTGTC	0.433		NA											32	89					0	0	0	0
CACNA1A	773	broad.mit.edu	37	19	13340911	13340911	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:13340911T>C	uc010dze.2	-	36	5752	c.5516A>G	c.(5515-5517)TAT>TGT	p.Y1839C	CACNA1A_uc010xnd.1_Missense_Mutation_p.Y544C|CACNA1A_uc002mwx.3_Missense_Mutation_p.Y544C|CACNA1A_uc010dzc.2_Missense_Mutation_p.Y1364C|CACNA1A_uc002mwy.3_Missense_Mutation_p.Y1838C|CACNA1A_uc002mwv.3_Missense_Mutation_p.Y355C	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	1839	Cytoplasmic (Potential).				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	TGCGGGGTCATACTCGGCCCA	0.587		NA											9	13					0	0	0	0
RFX1	5989	broad.mit.edu	37	19	14094399	14094399	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:14094399T>G	uc002mxv.2	-	3	600	c.328A>C	c.(328-330)ATG>CTG	p.M110L	RFX1_uc010dzi.2_Missense_Mutation_p.M110L	NM_002918	NP_002909	P22670	RFX1_HUMAN	regulatory factor X1	110					immune response	nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			lung(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(19;6.67e-23)			CTGGCCCGCATGGCACCTTCT	0.672		NA											3	10					0	0	0	0
ZNF99	7652	broad.mit.edu	37	19	22940748	22940748	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:22940748C>T	uc010xrh.1	-	5	1690	c.1690G>A	c.(1690-1692)GGT>AGT	p.G564S		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				AAAGCTTTACCACATTCTTCA	0.378		NA											11	49					0	0	0	0
ZNF254	9534	broad.mit.edu	37	19	24309076	24309076	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:24309076C>T	uc002nru.2	+	4	408	c.274C>T	c.(274-276)CAA>TAA	p.Q92*	ZNF254_uc010xrk.1_Nonsense_Mutation_p.Q7*	NM_203282	NP_975011	O75437	ZN254_HUMAN	zinc finger protein 254	92					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(12;0.086)|all_lung(12;0.00528)|Lung NSC(12;0.00731)|all_epithelial(12;0.0186)				TCATTTTGCTCAAGACCTTTG	0.308		NA											7	30					0	0	0	0
TSHZ3	57616	broad.mit.edu	37	19	31769884	31769884	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:31769884T>A	uc002nsy.3	-	2	880	c.815A>T	c.(814-816)CAG>CTG	p.Q272L		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	272					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					CAGCACCTTCTGGGCGTCTTC	0.512		NA											44	148					0	0	0	0
ZNF507	22847	broad.mit.edu	37	19	32844667	32844667	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:32844667G>A	uc002nte.2	+	3	1203	c.931G>A	c.(931-933)GAG>AAG	p.E311K	ZNF507_uc002ntc.2_Missense_Mutation_p.E311K|ZNF507_uc010xrn.1_Missense_Mutation_p.E311K|ZNF507_uc002ntd.2_Missense_Mutation_p.E311K	NM_001136156	NP_001129628	Q8TCN5	ZN507_HUMAN	zinc finger protein 507	311					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)|kidney(1)|central_nervous_system(1)|skin(1)	5	Esophageal squamous(110;0.162)					TGCTATTGGAGAGAGTGAACT	0.473		NA											47	159					0	0	0	0
FXYD3	5349	broad.mit.edu	37	19	35613703	35613703	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:35613703C>G	uc010xsn.1	+	7	458	c.132C>G	c.(130-132)TGC>TGG	p.C44W	FXYD3_uc010xsl.1_Missense_Mutation_p.C44W|FXYD3_uc010xsm.1_Missense_Mutation_p.C101W|FXYD3_uc002nxw.2_Missense_Mutation_p.C44W|FXYD3_uc002nxv.2_Missense_Mutation_p.C44W|FXYD3_uc010xso.1_Missense_Mutation_p.C44W	NM_001136011	NP_001129483	Q14802	FXYD3_HUMAN	FXYD domain containing ion transport regulator 3	44	Helical; (Potential).					chloride channel complex|integral to plasma membrane	chloride channel activity				0	all_lung(56;5.38e-08)|Lung NSC(56;8.61e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.54e-20)|OV - Ovarian serous cystadenocarcinoma(14;1.33e-18)|all cancers(14;4.27e-17)|LUSC - Lung squamous cell carcinoma(66;0.0849)			GGCTCATCTGCGCTGGGGTTC	0.637		NA											32	75					0	0	0	0
KIRREL2	84063	broad.mit.edu	37	19	36357124	36357124	+	Silent	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:36357124T>C	uc002ocb.3	+	15	2069	c.1857T>C	c.(1855-1857)CCT>CCC	p.P619P	KIRREL2_uc002obz.3_Intron|KIRREL2_uc002oca.3_Intron|KIRREL2_uc002occ.3_Silent_p.P566P|KIRREL2_uc002ocd.3_Silent_p.P581P|APLP1_uc010xsz.1_5'Flank|APLP1_uc002oce.2_5'Flank|APLP1_uc002ocf.2_5'Flank|APLP1_uc002ocg.2_5'Flank	NM_199180	NP_954649	Q6UWL6	KIRR2_HUMAN	kin of IRRE-like 2 isoform c	619	Cytoplasmic (Potential).				cell adhesion	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|skin(1)	3	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GCGAAGCCCCTGGAGGAGGTC	0.607		NA											20	88					0	0	0	0
ZNF540	163255	broad.mit.edu	37	19	38103945	38103945	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:38103945T>A	uc002ogq.2	+	5	2096	c.1764T>A	c.(1762-1764)TTT>TTA	p.F588L	ZNF540_uc002ogu.2_Missense_Mutation_p.F588L|ZNF540_uc010efq.2_Missense_Mutation_p.F556L	NM_152606	NP_689819	Q8NDQ6	ZN540_HUMAN	zinc finger protein 540	588	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)	1			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GGAAGGCCTTTAGTCGTAGTG	0.408		NA											18	51					0	0	0	0
RYR1	6261	broad.mit.edu	37	19	38956797	38956797	+	Silent	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:38956797G>C	uc002oit.2	+	24	3067	c.2937G>C	c.(2935-2937)GCG>GCC	p.A979A	RYR1_uc002oiu.2_Silent_p.A979A	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	979	2.|Cytoplasmic.|6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TGACGCCGGCGCAGACGACAC	0.652		NA											7	18					0	0	0	0
HIPK4	147746	broad.mit.edu	37	19	40886623	40886623	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:40886623G>T	uc002onp.2	-	3	1560	c.1275C>A	c.(1273-1275)GCC>GCA	p.A425A		NM_144685	NP_653286	Q8NE63	HIPK4_HUMAN	homeodomain interacting protein kinase 4	425						cytoplasm	ATP binding|protein serine/threonine kinase activity			ovary(1)|stomach(1)	2			Lung(22;4.95e-05)|LUSC - Lung squamous cell carcinoma(20;0.000292)			GCTGGTCGATGGCTCTTTGCA	0.617		NA											41	79					9.86e-28	2.06e-27	1	0
CYP2B6	1555	broad.mit.edu	37	19	41516003	41516003	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:41516003C>T	uc002opr.1	+	6	934	c.927C>T	c.(925-927)TAC>TAT	p.Y309Y	CYP2A7_uc002opo.2_Intron|CYP2B6_uc010xvu.1_Intron	NM_000767	NP_000758	P20813	CP2B6_HUMAN	cytochrome P450, family 2, subfamily B,	309					cellular ketone metabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2			LUSC - Lung squamous cell carcinoma(20;0.00322)		Bupropion(DB01156)|Butalbital(DB00241)|Carbamazepine(DB00564)|Clopidogrel(DB00758)|Cyclophosphamide(DB00531)|Efavirenz(DB00625)|Ifosfamide(DB01181)|Memantine(DB01043)|Meperidine(DB00454)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Midazolam(DB00683)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicotine(DB00184)|Orphenadrine(DB01173)|Phenytoin(DB00252)|Propofol(DB00818)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Ticlopidine(DB00208)|Troleandomycin(DB01361)	CTCTCCGCTACGGCTTCCTGC	0.562		NA											14	68					0	0	0	0
CEACAM7	1087	broad.mit.edu	37	19	42190981	42190981	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:42190981A>T	uc002ori.1	-	2	238	c.236T>A	c.(235-237)ATT>AAT	p.I79N	CEACAM7_uc010ehx.2_Missense_Mutation_p.I79N|CEACAM7_uc010ehy.1_Missense_Mutation_p.I79N	NM_006890	NP_008821	Q14002	CEAM7_HUMAN	carcinoembryonic antigen-related cell adhesion	79	Ig-like V-type.					anchored to membrane|integral to membrane|plasma membrane				ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(3;0.0027)|all cancers(3;0.00979)|Epithelial(262;0.0366)		ATATCCTATAATTCGATAGTT	0.458		NA											46	116					0	0	0	0
PSG6	5675	broad.mit.edu	37	19	43529181	43529181	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:43529181G>T	uc002ovh.1	-	2	199	c.110C>A	c.(109-111)CCT>CAT	p.P37H	PSG11_uc002ouw.2_Missense_Mutation_p.P37H|PSG10_uc002ouv.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Missense_Mutation_p.P37H|PSG11_uc002ovm.1_Missense_Mutation_p.P31H|PSG11_uc002ovn.1_Missense_Mutation_p.P37H|PSG11_uc002ovo.1_Intron|PSG11_uc002ovp.1_Intron			Q00889	PSG6_HUMAN	SubName: Full=Putative uncharacterized protein PSG6;	31					female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00899)				GGCAGTGGTAGGCAAGTTCCA	0.483		NA											50	153					4.01e-20	8.14e-20	1	0
PSG6	5675	broad.mit.edu	37	19	43585036	43585036	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:43585036A>G	uc002ovi.2	-	2	520	c.427T>C	c.(427-429)TAC>CAC	p.Y143H	PSG6_uc010xwk.1_Intron|PSG2_uc002ovr.2_Missense_Mutation_p.Y143H|PSG2_uc002ovq.3_Missense_Mutation_p.Y143H|PSG2_uc010eiq.1_Missense_Mutation_p.Y143H|PSG2_uc002ovs.3_Missense_Mutation_p.Y143H|PSG2_uc002ovt.3_Missense_Mutation_p.Y143H			Q00889	PSG6_HUMAN	SubName: Full=Putative uncharacterized protein PSG6;	142	Ig-like V-type.				female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00899)				CACTTACGGTATAAGGTGAAG	0.507		NA											37	131					0	0	0	0
XRCC1	7515	broad.mit.edu	37	19	44051050	44051050	+	Nonsense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:44051050T>A	uc002owt.2	-	11	1399	c.1279A>T	c.(1279-1281)AAG>TAG	p.K427*	XRCC1_uc010xwp.1_Nonsense_Mutation_p.K396*	NM_006297	NP_006288	P18887	XRCC1_HUMAN	X-ray repair cross complementing protein 1	427					base-excision repair|single strand break repair	nucleoplasm	damaged DNA binding|protein binding			ovary(2)|lung(2)|large_intestine(1)|prostate(1)|breast(1)	7		Prostate(69;0.0153)				TGAGGAAGCTTGGGGGCTTCA	0.617		NA						Other_BER_factors					18	64					0	0	0	0
CADM4	199731	broad.mit.edu	37	19	44131332	44131332	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:44131332G>T	uc002oxc.1	-	3	399	c.350C>A	c.(349-351)ACG>AAG	p.T117K		NM_145296	NP_660339	Q8NFZ8	CADM4_HUMAN	cell adhesion molecule 4 precursor	117	Ig-like V-type.|Extracellular (Potential).				cell adhesion	integral to membrane					0		Prostate(69;0.0199)				TACCGTGAGCGTGGCAATCTG	0.498		NA											26	71					2.46e-21	5.02e-21	1	0
OPA3	80207	broad.mit.edu	37	19	46056875	46056875	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:46056875T>A	uc002pck.3	-	2	537	c.437A>T	c.(436-438)CAG>CTG	p.Q146L	OPA3_uc002pcj.3_Intron|OPA3_uc010xxk.1_Missense_Mutation_p.Q93L	NM_025136	NP_079412	Q9H6K4	OPA3_HUMAN	OPA3 protein isoform b	146	Potential.				response to stimulus|visual perception	mitochondrion					0		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00778)|GBM - Glioblastoma multiforme(486;0.0976)|Epithelial(262;0.242)		CAGGGCGCCCTGTGGCGGCGC	0.716		NA											13	39					0	0	0	0
DMWD	1762	broad.mit.edu	37	19	46290016	46290016	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:46290016G>A	uc002pdj.1	-	3	784	c.738C>T	c.(736-738)CCC>CCT	p.P246P	DMWD_uc002pdk.1_Silent_p.P246P|DMWD_uc010eko.1_5'UTR	NM_004943	NP_004934	Q09019	DMWD_HUMAN	dystrophia myotonica-containing WD repeat motif	246	WD 1.				meiosis						0		Ovarian(192;0.0308)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00604)|GBM - Glioblastoma multiforme(486;0.0807)|Epithelial(262;0.236)		CCGAGGCGCAGGGGTGGCTGA	0.627		NA											22	43					0	0	0	0
GRLF1	2909	broad.mit.edu	37	19	47503715	47503715	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:47503715A>G	uc010ekv.2	+	6	4270	c.4270A>G	c.(4270-4272)ATC>GTC	p.I1424V		NM_004491	NP_004482	Q9NRY4	RHG35_HUMAN	glucocorticoid receptor DNA binding factor 1	1424	Rho-GAP.				axon guidance|negative regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol	DNA binding|Rho GTPase activator activity|transcription corepressor activity			central_nervous_system(1)	1		all_cancers(25;1.51e-09)|all_epithelial(76;1.87e-07)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|Ovarian(192;0.0129)|all_neural(266;0.026)|Breast(70;0.077)		all cancers(93;2.03e-05)|OV - Ovarian serous cystadenocarcinoma(262;2.57e-05)|Epithelial(262;0.00135)|GBM - Glioblastoma multiforme(486;0.0289)		CTACCAGACAATCATTGAACT	0.592		NA											60	146					0	0	0	0
KPTN	11133	broad.mit.edu	37	19	47978726	47978726	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:47978726G>T	uc002pgy.2	-	12	1362	c.1258C>A	c.(1258-1260)CAG>AAG	p.Q420K	KPTN_uc010xys.1_RNA	NM_007059	NP_008990	Q9Y664	KPTN_HUMAN	kaptin (actin binding protein)	420					actin filament organization|cellular component movement|sensory perception of sound	actin cytoskeleton|growth cone|microtubule organizing center|nucleus|perinuclear region of cytoplasm|stereocilium	actin binding			ovary(1)	1		all_cancers(25;1.55e-10)|all_epithelial(76;3.4e-08)|all_lung(116;1.73e-07)|Lung NSC(112;3.95e-07)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		OV - Ovarian serous cystadenocarcinoma(262;0.000428)|all cancers(93;0.000631)|Epithelial(262;0.0153)|GBM - Glioblastoma multiforme(486;0.0694)		TCCAACCCCTGTAGCCGACGT	0.612		NA											10	20					3.86e-05	6e-05	1	0
CRX	1406	broad.mit.edu	37	19	48339545	48339545	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:48339545G>A	uc002phq.3	+	3	350	c.146G>A	c.(145-147)AGC>AAC	p.S49N	CRX_uc010elm.1_RNA	NM_000554	NP_000545	O43186	CRX_HUMAN	cone-rod homeobox protein	49	Homeobox.				organ morphogenesis|response to stimulus|visual perception		leucine zipper domain binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)	2		all_cancers(25;2.76e-09)|all_epithelial(76;7.01e-07)|all_lung(116;2.48e-06)|Lung NSC(112;5.15e-06)|Ovarian(192;0.0139)|all_neural(266;0.0146)|Breast(70;0.133)		OV - Ovarian serous cystadenocarcinoma(262;0.000266)|all cancers(93;0.000788)|Epithelial(262;0.0226)|GBM - Glioblastoma multiforme(486;0.0521)		TTCACCCGGAGCCAACTGGAG	0.632		NA											22	58					0	0	0	0
PNKP	11284	broad.mit.edu	37	19	50364538	50364538	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:50364538C>A	uc002pqh.2	-	16	1585	c.1533G>T	c.(1531-1533)CTG>CTT	p.L511L	PNKP_uc002pqg.2_Silent_p.L292L|PNKP_uc002pqi.2_Silent_p.L472L|PNKP_uc002pqj.2_Silent_p.L511L|PNKP_uc010enm.2_Silent_p.L480L|PNKP_uc002pqk.2_3'UTR	NM_007254	NP_009185	Q96T60	PNKP_HUMAN	polynucleotide kinase 3' phosphatase	511					DNA damage response, detection of DNA damage|DNA-dependent DNA replication|nucleotide-excision repair, DNA damage removal|response to oxidative stress|response to radiation	nucleolus	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|damaged DNA binding|double-stranded DNA binding|endonuclease activity|nucleotide kinase activity|polynucleotide 3'-phosphatase activity|protein binding			ovary(1)|kidney(1)	2		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0118)|OV - Ovarian serous cystadenocarcinoma(262;0.0134)		ACAGCCGCCCCAGCCTCGGCT	0.622		NA						Other_BER_factors					45	80					1.85e-21	3.77e-21	1	0
C19orf41	126123	broad.mit.edu	37	19	50657863	50657863	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:50657863A>G	uc002prp.1	-	6	704	c.617T>C	c.(616-618)GTG>GCG	p.V206A		NM_152358	NP_689571	Q6UXV1	IZUM2_HUMAN	hypothetical protein LOC126123 precursor	206	Helical; (Potential).					integral to membrane					0		all_neural(266;0.0459)|Ovarian(192;0.0728)		GBM - Glioblastoma multiforme(134;0.00364)|OV - Ovarian serous cystadenocarcinoma(262;0.0052)		TCACGAGACCACGATGACCAC	0.577		NA											20	36					0	0	0	0
SYT3	84258	broad.mit.edu	37	19	51133373	51133373	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:51133373G>T	uc002pst.2	-	3	1364	c.730C>A	c.(730-732)CCC>ACC	p.P244T	SYT3_uc002psv.2_Missense_Mutation_p.P244T|SYT3_uc010ycd.1_Missense_Mutation_p.P244T	NM_032298	NP_115674	Q9BQG1	SYT3_HUMAN	synaptotagmin III	244	Cytoplasmic (Potential).					cell junction|endosome|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(2)|breast(1)	3		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00462)|GBM - Glioblastoma multiforme(134;0.0188)		TCACTGCTGGGGTCCGGCTGG	0.642		NA											9	25					2.18e-05	3.43e-05	1	0
GPR32	2854	broad.mit.edu	37	19	51274592	51274592	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:51274592G>T	uc010ycf.1	+	1	735	c.735G>T	c.(733-735)CGG>CGT	p.R245R		NM_001506	NP_001497	O75388	GPR32_HUMAN	G protein-coupled receptor 32	245	Cytoplasmic (Potential).					integral to plasma membrane	N-formyl peptide receptor activity			upper_aerodigestive_tract(1)	1		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		AGCTCTTGCGGGAGGGCTGGG	0.602		NA											20	49					4.63e-17	9.15e-17	1	0
CEACAM18	729767	broad.mit.edu	37	19	51984682	51984682	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:51984682A>G	uc002pwv.1	+	4	619	c.619A>G	c.(619-621)AGC>GGC	p.S207G		NM_001080405	NP_001073874	A8MTB9	CEA18_HUMAN	carcinoembryonic antigen-related cell adhesion	207						integral to membrane				skin(1)	1		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		CGTCAATGCCAGCTCCCTGGT	0.502		NA											13	35					0	0	0	0
PRKCG	5582	broad.mit.edu	37	19	54401341	54401341	+	Silent	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:54401341T>C	uc002qcq.1	+	10	1350	c.1068T>C	c.(1066-1068)GTT>GTC	p.V356V	PRKCG_uc010yef.1_Missense_Mutation_p.F327S|PRKCG_uc010yeg.1_Silent_p.V356V|PRKCG_uc010yeh.1_Silent_p.V243V	NM_002739	NP_002730	P05129	KPCG_HUMAN	protein kinase C, gamma	356	Protein kinase.				activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			lung(4)|ovary(2)|pancreas(2)|large_intestine(1)	9	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		TCCTCATGGTTCTAGGAAAAG	0.502		NA											19	42					0	0	0	0
PRKCG	5582	broad.mit.edu	37	19	54403889	54403889	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:54403889G>A	uc002qcq.1	+	14	1743	c.1461G>A	c.(1459-1461)ATG>ATA	p.M487I	PRKCG_uc010yeg.1_Missense_Mutation_p.M487I|PRKCG_uc010yeh.1_Missense_Mutation_p.M374I	NM_002739	NP_002730	P05129	KPCG_HUMAN	protein kinase C, gamma	487	Protein kinase.				activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			lung(4)|ovary(2)|pancreas(2)|large_intestine(1)	9	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		ACAATGTGATGCTGGATGCTG	0.542		NA											70	129					0	0	0	0
LILRA6	79168	broad.mit.edu	37	19	54742904	54742904	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:54742904G>T	uc002qeu.1	-	8	1495	c.1371C>A	c.(1369-1371)GTC>GTA	p.V457V	LILRB3_uc002qeh.1_Intron|LILRB3_uc002qeg.1_Intron|LILRB3_uc002qei.1_Intron|LILRA6_uc002qek.1_Intron|LILRB3_uc010erh.1_Intron|LILRB3_uc002qej.1_Intron|LILRA6_uc002qel.1_Intron|LILRA6_uc002qem.1_Intron|LILRB3_uc002qen.1_Intron|LILRB3_uc002qeo.1_Intron|LILRB3_uc002qep.1_Intron|LILRB3_uc002qeq.1_Intron|LILRB3_uc002qer.1_Intron|LILRB3_uc002qes.1_Intron|LILRA6_uc010yep.1_Intron|LILRA6_uc010yeq.1_Intron|LILRA6_uc002qet.3_RNA|LILRA6_uc002qev.1_Silent_p.V301V	NM_024318	NP_077294	Q6PI73	LIRA6_HUMAN	leukocyte immunoglobulin-like receptor,	457	Helical; (Potential).					integral to membrane	receptor activity			skin(2)	2	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GGAACACCAGGACCAAGCCTG	0.577		NA											19	55					1.34e-09	2.36e-09	1	0
LILRA4	23547	broad.mit.edu	37	19	54848235	54848235	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:54848235C>A	uc002qfj.2	-	6	1189	c.1132G>T	c.(1132-1134)GCT>TCT	p.A378S	LILRA4_uc002qfi.2_Missense_Mutation_p.A312S	NM_012276	NP_036408	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor subfamily	378	Ig-like C2-type 4.|Extracellular (Potential).					integral to membrane	receptor activity			upper_aerodigestive_tract(1)|central_nervous_system(1)	2	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		GGGAATTCAGCCTGGTACTTA	0.587		NA											51	158					1.21e-23	2.52e-23	1	0
LILRB1	10859	broad.mit.edu	37	19	55146717	55146717	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:55146717C>A	uc002qgj.2	+	13	1907	c.1567C>A	c.(1567-1569)CCA>ACA	p.P523T	LILRB1_uc010erp.1_Missense_Mutation_p.P138T|LILRB1_uc002qgl.2_Missense_Mutation_p.P523T|LILRB1_uc002qgk.2_Missense_Mutation_p.P524T|LILRB1_uc002qgm.2_Missense_Mutation_p.P524T|LILRB1_uc010erq.2_Missense_Mutation_p.P507T|LILRB1_uc010err.2_RNA	NM_006669	NP_006660	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor,	523	Cytoplasmic (Potential).				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			large_intestine(1)|ovary(1)|skin(1)	3				GBM - Glioblastoma multiforme(193;0.0188)		CAGGTCCAGCCCAGCTGCCGA	0.607		NA								HNSCC(37;0.09)			15	77					0.000422831	0.00063337	1	0
NCR1	9437	broad.mit.edu	37	19	55417664	55417664	+	Nonsense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:55417664T>A	uc002qib.2	+	2	80	c.42T>A	c.(40-42)TGT>TGA	p.C14*	NCR1_uc002qic.2_Nonsense_Mutation_p.C14*|NCR1_uc002qie.2_Nonsense_Mutation_p.C14*|NCR1_uc002qid.2_Nonsense_Mutation_p.C14*|NCR1_uc002qif.2_Nonsense_Mutation_p.C14*|NCR1_uc010esj.2_Intron	NM_004829	NP_004820	O76036	NCTR1_HUMAN	natural cytotoxicity triggering receptor 1	14					cellular defense response|natural killer cell activation|regulation of natural killer cell mediated cytotoxicity	integral to plasma membrane|SWI/SNF complex	receptor activity|receptor signaling protein activity			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(193;0.0449)		CAGGGCTGTGTCTGAGTCAGA	0.612		NA											14	56					0	0	0	0
NLRP4	147945	broad.mit.edu	37	19	56370017	56370017	+	Silent	SNP	C	C	A	rs140509890		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:56370017C>A	uc002qmd.3	+	3	1680	c.1258C>A	c.(1258-1260)CGG>AGG	p.R420R	NLRP4_uc002qmf.2_Silent_p.R345R|NLRP4_uc010etf.2_Silent_p.R251R	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	420	NACHT.						ATP binding	p.R420Q(1)		ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		AGACGACCTCCGGAGAAATGG	0.582		NA											32	104					4.75e-14	9.02e-14	1	0
NLRP4	147945	broad.mit.edu	37	19	56372754	56372754	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:56372754C>A	uc002qmd.3	+	4	2281	c.1859C>A	c.(1858-1860)TCG>TAG	p.S620*	NLRP4_uc002qmf.2_Nonsense_Mutation_p.S545*|NLRP4_uc010etf.2_Nonsense_Mutation_p.S451*	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	620							ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		GACCACAGGTCGGATTACAGC	0.552		NA											16	25					1.57e-10	2.84e-10	1	0
NLRP4	147945	broad.mit.edu	37	19	56382227	56382227	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:56382227G>A	uc002qmd.3	+	7	2811	c.2389G>A	c.(2389-2391)GAA>AAA	p.E797K	NLRP4_uc002qmf.2_Missense_Mutation_p.E722K|NLRP4_uc010etf.2_Missense_Mutation_p.E572K	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	797							ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		GCAGTGCTGCGAATACATCTC	0.512		NA											25	51					0	0	0	0
PEG3	5178	broad.mit.edu	37	19	57335011	57335011	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:57335011A>T	uc002qnu.2	-	2	782	c.431T>A	c.(430-432)ATG>AAG	p.M144K	ZIM2_uc010ygq.1_5'UTR|ZIM2_uc010ygr.1_5'UTR|ZIM2_uc002qnr.2_Missense_Mutation_p.M18K|ZIM2_uc002qnq.2_Missense_Mutation_p.M18K|ZIM2_uc010etp.2_Missense_Mutation_p.M18K|ZIM2_uc010ygs.1_Missense_Mutation_p.M18K|PEG3_uc002qnt.2_Missense_Mutation_p.M144K|PEG3_uc002qnv.2_Missense_Mutation_p.M144K|PEG3_uc002qnw.2_Missense_Mutation_p.M18K|PEG3_uc002qnx.2_Missense_Mutation_p.M18K|PEG3_uc010etr.2_Missense_Mutation_p.M144K	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	144					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		GTTCCGGGTCATGTCGTCGTC	0.552		NA											29	62					0	0	0	0
USP29	57663	broad.mit.edu	37	19	57641686	57641686	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:57641686C>T	uc002qny.2	+	4	1999	c.1643C>T	c.(1642-1644)CCT>CTT	p.P548L		NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	548					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(6)|ovary(2)|breast(2)|pancreas(1)	11		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		ACCAAACCACCTCTTCCCTTG	0.418		NA											52	143					0	0	0	0
ZNF324B	388569	broad.mit.edu	37	19	58967712	58967712	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:58967712G>T	uc002qsv.1	+	4	1508	c.1401G>T	c.(1399-1401)GTG>GTT	p.V467V	ZNF324B_uc002qsu.1_Silent_p.V457V|ZNF324B_uc010euq.1_Silent_p.V467V	NM_207395	NP_997278	Q6AW86	Z324B_HUMAN	zinc finger protein 324B	467	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		AGGGCGCCGTGCTGCTCAGCC	0.682		NA											23	68					1.23e-08	2.12e-08	1	0
TPO	7173	broad.mit.edu	37	2	1480964	1480964	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:1480964C>A	uc002qww.2	+	8	1017	c.926C>A	c.(925-927)TCC>TAC	p.S309Y	TPO_uc010ewj.2_Intron|TPO_uc002qwu.2_Missense_Mutation_p.S309Y|TPO_uc002qwr.2_Missense_Mutation_p.S309Y|TPO_uc002qwx.2_Missense_Mutation_p.S309Y|TPO_uc010yio.1_Intron|TPO_uc010yip.1_Missense_Mutation_p.S309Y	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	309	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	GGGAACCTGTCCACGGCCAAC	0.706		NA											9	25					7.48e-07	1.24e-06	1	0
PXDN	7837	broad.mit.edu	37	2	1658260	1658260	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:1658260C>A	uc002qxa.2	-	15	1922	c.1858G>T	c.(1858-1860)GGA>TGA	p.G620*	PXDN_uc002qxb.1_Nonsense_Mutation_p.G620*	NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	620					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		AACGGATCTCCATTTCGACTG	0.428		NA											15	32					7.93e-07	1.31e-06	1	0
PXDN	7837	broad.mit.edu	37	2	1680770	1680770	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:1680770C>T	uc002qxa.2	-	8	841	c.777G>A	c.(775-777)TCG>TCA	p.S259S	PXDN_uc002qxb.1_Silent_p.S259S|PXDN_uc002qxc.1_Silent_p.S76S	NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	259	Ig-like C2-type 1.				extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		CGGTGTTCCCCGAGGTCACAT	0.532		NA											6	14					0	0	0	0
MYT1L	23040	broad.mit.edu	37	2	1890319	1890319	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:1890319T>A	uc002qxe.2	-	18	3530	c.2703A>T	c.(2701-2703)CAA>CAT	p.Q901H	MYT1L_uc002qxd.2_Missense_Mutation_p.Q899H|MYT1L_uc010ewl.1_RNA	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	901					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		ACTTGAGTTCTTGGGAGCTGG	0.433		NA											18	42					0	0	0	0
MYT1L	23040	broad.mit.edu	37	2	1914014	1914014	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:1914014G>A	uc002qxe.2	-	13	2642	c.1815C>T	c.(1813-1815)CTC>CTT	p.L605L	MYT1L_uc002qxd.2_Silent_p.L603L|MYT1L_uc010ewl.1_RNA	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	605					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		CTGGGTACCTGAGCACGCGGT	0.637		NA											5	37					0	0	0	0
ADAM17	6868	broad.mit.edu	37	2	9666299	9666299	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:9666299C>G	uc002qzu.2	-	6	877	c.694G>C	c.(694-696)GAT>CAT	p.D232H	ADAM17_uc010ewy.2_Missense_Mutation_p.D232H|ADAM17_uc010ewz.2_Intron|ADAM17_uc010exa.2_5'Flank|ADAM17_uc010exb.1_3'UTR	NM_003183	NP_003174	P78536	ADA17_HUMAN	a disintegrin and metalloprotease domain 17	232	Peptidase M12B.|Extracellular (Potential).				B cell differentiation|cell adhesion mediated by integrin|epidermal growth factor receptor signaling pathway|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|germinal center formation|membrane protein intracellular domain proteolysis|negative regulation of interleukin-8 production|nerve growth factor receptor signaling pathway|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of chemokine production|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of protein phosphorylation|positive regulation of T cell chemotaxis|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of mast cell apoptosis|response to drug|response to high density lipoprotein particle stimulus|response to hypoxia|response to lipopolysaccharide|spleen development|T cell differentiation in thymus|wound healing, spreading of epidermal cells	actin cytoskeleton|apical plasma membrane|cell surface|cytoplasm|integral to plasma membrane|membrane raft	integrin binding|interleukin-6 receptor binding|metalloendopeptidase activity|PDZ domain binding|SH3 domain binding|zinc ion binding			lung(1)|kidney(1)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.225)		AAGCGATGATCTGCTACCACC	0.358		NA											35	92					0	0	0	0
GREB1	9687	broad.mit.edu	37	2	11702672	11702672	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:11702672C>G	uc002rbk.1	+	3	541	c.241C>G	c.(241-243)CTG>GTG	p.L81V	GREB1_uc002rbl.2_Missense_Mutation_p.L81V|GREB1_uc002rbm.2_5'UTR|GREB1_uc002rbn.1_Missense_Mutation_p.L81V	NM_014668	NP_055483	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	81						integral to membrane				ovary(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		CCCTTTCCAGCTGCACCCTCT	0.612		NA											29	87					0	0	0	0
NBAS	51594	broad.mit.edu	37	2	15470842	15470842	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:15470842C>A	uc002rcc.1	-	36	4253	c.4227G>T	c.(4225-4227)TGG>TGT	p.W1409C	NBAS_uc010exl.1_Missense_Mutation_p.W481C|NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	1409										ovary(2)|liver(1)|skin(1)	4						TAGCAGTGGTCCAGCGCAATA	0.468		NA											19	57					2.46e-09	4.32e-09	1	0
APOB	338	broad.mit.edu	37	2	21230042	21230042	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:21230042T>C	uc002red.2	-	26	9826	c.9698A>G	c.(9697-9699)TAC>TGC	p.Y3233C		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	3233	Heparin-binding.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TTCAGCTTTGTACTTATCAAA	0.363		NA											19	27					0	0	0	0
APOB	338	broad.mit.edu	37	2	21235485	21235485	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:21235485T>A	uc002red.2	-	26	4383	c.4255A>T	c.(4255-4257)ACA>TCA	p.T1419S		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	1419					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity	p.T1419A(1)		ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TATGATAGTGTGAACGTATTC	0.343		NA											9	45					0	0	0	0
C2orf53	339779	broad.mit.edu	37	2	27360306	27360306	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:27360306A>T	uc002rjb.2	-	3	1472	c.892T>A	c.(892-894)TTC>ATC	p.F298I	PREB_uc002rix.1_5'Flank|PREB_uc002riy.1_5'Flank|PREB_uc002riz.1_5'Flank|PREB_uc002rja.1_5'Flank	NM_178553	NP_848648	Q53SZ7	CB053_HUMAN	hypothetical protein LOC339779	298											0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CGGAGGCCGAAGCCGATGCCT	0.657		NA											15	36					0	0	0	0
TRMT61B	55006	broad.mit.edu	37	2	29092590	29092590	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:29092590C>A	uc002rmm.2	-	1	586	c.554G>T	c.(553-555)GGG>GTG	p.G185V	TRMT61B_uc002rmn.2_Missense_Mutation_p.G185V|TRMT61B_uc010ezk.2_RNA	NM_017910	NP_060380	Q9BVS5	TR61B_HUMAN	tRNA methyltransferase 61 homolog B	185							tRNA (adenine-N1-)-methyltransferase activity				0						CGGGACTGCCCCCCAGTTACT	0.498		NA											33	91					2.68e-12	4.94e-12	1	0
WDR43	23160	broad.mit.edu	37	2	29158393	29158393	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:29158393C>T	uc002rmo.2	+	12	1476	c.1444C>T	c.(1444-1446)CTT>TTT	p.L482F		NM_015131	NP_055946	Q15061	WDR43_HUMAN	WD repeat domain 43	482						nucleolus				ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)					ACAGAAAGTACTTCAAACTAG	0.318		NA											10	39					0	0	0	0
CAPN13	92291	broad.mit.edu	37	2	30959385	30959385	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:30959385C>G	uc002rnn.2	-	17	1882	c.1706G>C	c.(1705-1707)CGC>CCC	p.R569P	CAPN13_uc002rnm.2_RNA	NM_144575	NP_653176	Q6MZZ7	CAN13_HUMAN	calpain 13	569	EF-hand 1.				proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			large_intestine(1)|ovary(1)	2	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.155)					GTGAACAAGGCGCTTCCACAG	0.408		NA											23	46					0	0	0	0
NLRC4	58484	broad.mit.edu	37	2	32474682	32474682	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:32474682G>A	uc002roi.2	-	4	2497	c.2251C>T	c.(2251-2253)CTG>TTG	p.L751L	NLRC4_uc002roj.1_Silent_p.L751L|NLRC4_uc010ezt.1_Intron	NM_021209	NP_067032	Q9NPP4	NLRC4_HUMAN	caspase recruitment domain protein 12	751	LRR 5.				activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity			ovary(3)|large_intestine(1)|lung(1)|skin(1)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					ATACCCGGCAGCCGTTGATTC	0.318		NA											69	184					0	0	0	0
NLRC4	58484	broad.mit.edu	37	2	32475967	32475967	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:32475967C>T	uc002roi.2	-	4	1212	c.966G>A	c.(964-966)TTG>TTA	p.L322L	NLRC4_uc002roj.1_Silent_p.L322L|NLRC4_uc010ezt.1_Intron	NM_021209	NP_067032	Q9NPP4	NLRC4_HUMAN	caspase recruitment domain protein 12	322	NACHT.				activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity			ovary(3)|large_intestine(1)|lung(1)|skin(1)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					GAATTTGGAGCAACAAGCCTT	0.507		NA											18	51					0	0	0	0
LTBP1	4052	broad.mit.edu	37	2	33540329	33540329	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:33540329G>A	uc002ros.2	+	24	3726	c.3726G>A	c.(3724-3726)ACG>ACA	p.T1242T	LTBP1_uc002rot.2_Silent_p.T916T|LTBP1_uc002rou.2_Silent_p.T915T|LTBP1_uc002rov.2_Silent_p.T862T|LTBP1_uc010ymz.1_Silent_p.T915T|LTBP1_uc010yna.1_Silent_p.T862T|LTBP1_uc010ynb.1_Silent_p.T181T	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	1241	EGF-like 12; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				ATGGCCGTACGTGTGAAGGTA	0.448		NA											13	31					0	0	0	0
RASGRP3	25780	broad.mit.edu	37	2	33741637	33741637	+	Silent	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:33741637T>C	uc002rox.2	+	5	726	c.99T>C	c.(97-99)TAT>TAC	p.Y33Y	RASGRP3_uc010ync.1_Silent_p.Y33Y|RASGRP3_uc002roy.2_Silent_p.Y33Y	NM_170672	NP_733772	Q8IV61	GRP3_HUMAN	RAS guanyl releasing protein 3 (calcium and	33	N-terminal Ras-GEF.				MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity|protein binding|Rap GTPase activator activity|signal transducer activity			lung(3)|ovary(1)|pancreas(1)	5	all_hematologic(175;0.115)					ATAATAGTTATTTGCCAAGAA	0.328		NA											2	9					0	0	0	0
SLC8A1	6546	broad.mit.edu	37	2	40656936	40656936	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:40656936G>T	uc002rrx.2	-	1	509	c.485C>A	c.(484-486)ACT>AAT	p.T162N	SLC8A1_uc002rry.2_Missense_Mutation_p.T162N|SLC8A1_uc002rrz.2_Missense_Mutation_p.T162N|SLC8A1_uc002rsa.2_Missense_Mutation_p.T162N|SLC8A1_uc002rsd.3_Missense_Mutation_p.T162N|SLC8A1_uc002rsb.1_Missense_Mutation_p.T162N|SLC8A1_uc010fan.1_Missense_Mutation_p.T162N|SLC8A1_uc002rsc.1_Missense_Mutation_p.T162N	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	162	Extracellular (Potential).|Alpha-1.				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	GTCTCCTGCAGTGAAGTTATG	0.468		NA											20	57					1.56e-12	2.89e-12	1	0
NRXN1	9378	broad.mit.edu	37	2	50779852	50779852	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:50779852C>T	uc010fbq.2	-	9	3229	c.1752G>A	c.(1750-1752)GAG>GAA	p.E584E	NRXN1_uc002rxb.3_Silent_p.E216E|NRXN1_uc002rxe.3_Silent_p.E544E|NRXN1_uc002rxc.1_RNA	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			CATCTAGCATCTCAATAGCAA	0.448		NA											30	73					0	0	0	0
NRXN1	9378	broad.mit.edu	37	2	50779857	50779857	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:50779857T>C	uc010fbq.2	-	9	3224	c.1747A>G	c.(1747-1749)ATT>GTT	p.I583V	NRXN1_uc002rxb.3_Missense_Mutation_p.I215V|NRXN1_uc002rxe.3_Missense_Mutation_p.I543V|NRXN1_uc002rxc.1_RNA	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			AGCATCTCAATAGCAAAGAAG	0.443		NA											27	79					0	0	0	0
NRXN1	9378	broad.mit.edu	37	2	51254661	51254661	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:51254661G>T	uc010fbq.2	-	2	2228	c.751C>A	c.(751-753)CGC>AGC	p.R251S	NRXN1_uc002rxe.3_Missense_Mutation_p.R251S|NRXN1_uc002rxd.1_Missense_Mutation_p.R251S	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:Variant_position_missing_in_P58400_after_alignment					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			TCCTTGCCGCGGAAGCCGGTT	0.751		NA											5	30					0.000602214	0.000897232	1	0
NRXN1	9378	broad.mit.edu	37	2	51254722	51254722	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:51254722G>T	uc010fbq.2	-	2	2167	c.690C>A	c.(688-690)AAC>AAA	p.N230K	NRXN1_uc002rxe.3_Missense_Mutation_p.N230K|NRXN1_uc002rxd.1_Missense_Mutation_p.N230K	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:Variant_position_missing_in_P58400_after_alignment					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			ACACACCTCCGTTGAGGCACA	0.711		NA											11	15					4.69e-08	7.99e-08	1	0
CCDC104	112942	broad.mit.edu	37	2	55756024	55756024	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:55756024A>T	uc002ryy.2	+	4	491	c.293A>T	c.(292-294)CAA>CTA	p.Q98L	CCDC104_uc002ryx.2_Missense_Mutation_p.Q123L	NM_080667	NP_542398	Q96G28	CC104_HUMAN	coiled-coil domain containing 104	98										ovary(1)	1			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			GCCATTTTGCAACCTGTGTTG	0.363		NA											5	34					0	0	0	0
MEIS1	4211	broad.mit.edu	37	2	66664968	66664968	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:66664968C>T	uc002sdu.2	+	2	569	c.112C>T	c.(112-114)CAC>TAC	p.H38Y	MEIS1_uc002sdt.2_Missense_Mutation_p.H38Y|MEIS1_uc002sdv.2_Missense_Mutation_p.H36Y|MEIS1_uc010yqh.1_RNA|MEIS1_uc010yqi.1_5'Flank|MEIS1_uc002sdw.1_5'Flank	NM_002398	NP_002389	O00470	MEIS1_HUMAN	Meis homeobox 1	38							sequence-specific DNA binding transcription factor activity				0						GCCGGTCCACCACCTGAACCA	0.612		NA											7	25					0	0	0	0
DYSF	8291	broad.mit.edu	37	2	71797809	71797809	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:71797809C>T	uc002sie.2	+	29	3488	c.3112C>T	c.(3112-3114)CGA>TGA	p.R1038*	DYSF_uc010feg.2_Nonsense_Mutation_p.R1069*|DYSF_uc010feh.2_Nonsense_Mutation_p.R1024*|DYSF_uc002sig.3_Nonsense_Mutation_p.R1024*|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Nonsense_Mutation_p.R1038*|DYSF_uc010fef.2_Nonsense_Mutation_p.R1055*|DYSF_uc010fei.2_Nonsense_Mutation_p.R1055*|DYSF_uc010fek.2_Nonsense_Mutation_p.R1056*|DYSF_uc010fej.2_Nonsense_Mutation_p.R1025*|DYSF_uc010fel.2_Nonsense_Mutation_p.R1025*|DYSF_uc010feo.2_Nonsense_Mutation_p.R1070*|DYSF_uc010fem.2_Nonsense_Mutation_p.R1039*|DYSF_uc010fen.2_Nonsense_Mutation_p.R1056*|DYSF_uc002sif.2_Nonsense_Mutation_p.R1039*	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	1038	Cytoplasmic (Potential).|Arg-rich.		R -> Q (in LGMD2B; uncertain pathogenicity).			cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						CTACACACACCGACGGCGGCG	0.642		NA											14	32					0	0	0	0
RAB11FIP5	26056	broad.mit.edu	37	2	73315415	73315415	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:73315415G>A	uc002siu.3	-	3	1572	c.1331C>T	c.(1330-1332)TCT>TTT	p.S444F	RAB11FIP5_uc002sit.3_Missense_Mutation_p.S366F	NM_015470	NP_056285	Q9BXF6	RFIP5_HUMAN	RAB11 family interacting protein 5 (class I)	444					protein transport	mitochondrial outer membrane|recycling endosome membrane	gamma-tubulin binding				0						CACAGCCTCAGAGGAGGCCAC	0.657		NA											39	88					0	0	0	0
RAB11FIP5	26056	broad.mit.edu	37	2	73315801	73315801	+	Silent	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:73315801C>G	uc002siu.3	-	3	1186	c.945G>C	c.(943-945)GTG>GTC	p.V315V	RAB11FIP5_uc002sit.3_Silent_p.V237V	NM_015470	NP_056285	Q9BXF6	RFIP5_HUMAN	RAB11 family interacting protein 5 (class I)	315					protein transport	mitochondrial outer membrane|recycling endosome membrane	gamma-tubulin binding				0						GAGGAGGAGCCACTCGCATCT	0.592		NA											6	23					0	0	0	0
CCDC142	84865	broad.mit.edu	37	2	74709692	74709692	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:74709692G>A	uc002slr.2	-	1	666	c.273C>T	c.(271-273)CTC>CTT	p.L91L	TTC31_uc002sls.2_5'Flank|TTC31_uc010yrv.1_5'Flank|TTC31_uc002slt.2_5'Flank|TTC31_uc002slu.2_5'Flank|CCDC142_uc002slo.2_RNA|CCDC142_uc002slq.2_Silent_p.L91L|CCDC142_uc002slp.2_Silent_p.L91L	NM_032779	NP_116168	Q17RM4	CC142_HUMAN	coiled-coil domain containing 142	91	Potential.									central_nervous_system(1)	1						ACACCGCCCGGAGACGCTGCA	0.716		NA											7	8					0	0	0	0
AUP1	550	broad.mit.edu	37	2	74754875	74754875	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:74754875G>A	uc010yrx.1	-	7	1126	c.1000C>T	c.(1000-1002)CGC>TGC	p.R334C	DQX1_uc010yrw.1_5'Flank|AUP1_uc002sme.2_Missense_Mutation_p.R10C|AUP1_uc002smf.2_Missense_Mutation_p.R277C|AUP1_uc002smg.2_RNA|AUP1_uc002smh.2_Missense_Mutation_p.R186C|HTRA2_uc002smi.1_5'Flank|HTRA2_uc002smj.1_5'Flank|HTRA2_uc002smk.1_5'Flank|HTRA2_uc002sml.1_5'Flank|HTRA2_uc002smm.1_5'Flank|HTRA2_uc002smn.1_5'Flank|HTRA2_uc010ffl.2_5'Flank			Q9Y679	AUP1_HUMAN	SubName: Full=cDNA FLJ57204, highly similar to Homo sapiens ancient ubiquitous protein 1 (AUP1), transcript variant 2, mRNA;	343	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane|nucleus	protein binding				0						GACTGGGGGCGCAATCTGGGG	0.512		NA											50	129					0	0	0	0
LRRTM4	80059	broad.mit.edu	37	2	77746849	77746849	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:77746849G>T	uc002snr.2	-	3	561	c.146C>A	c.(145-147)TCT>TAT	p.S49Y	LRRTM4_uc002snq.2_Missense_Mutation_p.S49Y|LRRTM4_uc002sns.2_Missense_Mutation_p.S49Y|LRRTM4_uc002snt.2_Missense_Mutation_p.S50Y	NM_001134745	NP_001128217	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	49	Extracellular (Potential).|LRRNT.					integral to membrane				pancreas(3)|ovary(1)	4				Colorectal(11;0.059)		GAAAGCATGAGACTCACAGTA	0.463		NA											27	72					1.18e-12	2.18e-12	1	0
CTNNA2	1496	broad.mit.edu	37	2	80136847	80136847	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:80136847G>T	uc010ysh.1	+	6	985	c.980G>T	c.(979-981)CGG>CTG	p.R327L	CTNNA2_uc010yse.1_Missense_Mutation_p.R327L|CTNNA2_uc010ysf.1_Missense_Mutation_p.R327L|CTNNA2_uc010ysg.1_Missense_Mutation_p.R327L	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	327					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						CGAGACGACCGGCGCGAGAGG	0.637		NA											33	74					5.83e-16	1.14e-15	1	0
CTNNA2	1496	broad.mit.edu	37	2	80816527	80816527	+	Silent	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:80816527C>G	uc010ysh.1	+	14	2111	c.2106C>G	c.(2104-2106)GCC>GCG	p.A702A	CTNNA2_uc010yse.1_Silent_p.A702A|CTNNA2_uc010ysf.1_Silent_p.A702A|CTNNA2_uc010ysg.1_Silent_p.A702A|CTNNA2_uc010ysi.1_Silent_p.A334A|CTNNA2_uc010ysj.1_Silent_p.A31A	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	702					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						CAGAAGTGGCCAAATGGGACG	0.498		NA											35	57					0	0	0	0
PTCD3	55037	broad.mit.edu	37	2	86350830	86350830	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:86350830G>T	uc002sqw.2	+	9	727	c.661G>T	c.(661-663)GAA>TAA	p.E221*	PTCD3_uc010ytc.1_RNA|PTCD3_uc002sqx.1_5'Flank	NM_017952	NP_060422	Q96EY7	PTCD3_HUMAN	pentatricopeptide repeat domain 3 precursor	221						mitochondrion	protein binding			ovary(1)	1						TCAGGAAGAGGAAAATGATGA	0.383		NA											14	36					3.27e-08	5.61e-08	1	0
ADRA2B	151	broad.mit.edu	37	2	96780851	96780851	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:96780851C>A	uc002svi.2	-	3	1047	c.1047G>T	c.(1045-1047)GTG>GTT	p.V349V		NM_000682	NP_000673	P18089	ADA2B_HUMAN	alpha-2B-adrenergic receptor	349	Cytoplasmic (By similarity).				activation of MAPK activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cell-cell signaling|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|negative regulation of epinephrine secretion|negative regulation of norepinephrine secretion|positive regulation of neuron differentiation	integral to plasma membrane	alpha2-adrenergic receptor activity|epinephrine binding|protein binding			ovary(2)|lung(1)	3					Bethanidine(DB00217)|Brimonidine(DB00484)|Debrisoquin(DB04840)|Ergotamine(DB00696)|Fenoldopam(DB00800)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Lofexidine(DB04948)|Norepinephrine(DB00368)|Yohimbine(DB01392)	CTATAGCACCCACGCCCCTGC	0.677		NA											7	16					0.00198382	0.0028924	1	0
NCAPH	23397	broad.mit.edu	37	2	97008569	97008569	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:97008569G>C	uc002svz.1	+	4	523	c.439G>C	c.(439-441)GAA>CAA	p.E147Q	NCAPH_uc010fhu.1_Missense_Mutation_p.E123Q|NCAPH_uc010fhv.1_Missense_Mutation_p.E136Q|NCAPH_uc010yum.1_Missense_Mutation_p.E123Q|NCAPH_uc010fhw.1_Missense_Mutation_p.E136Q|NCAPH_uc010yun.1_Missense_Mutation_p.E11Q|NCAPH_uc002swa.1_Intron	NM_015341	NP_056156	Q15003	CND2_HUMAN	non-SMC condensin I complex, subunit H	147					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|microtubule cytoskeleton|nucleus				urinary_tract(1)|skin(1)	2		Ovarian(717;0.0221)				GAAAGACACCGAACCAACCAA	0.353		NA											14	37					0	0	0	0
FER1L5	90342	broad.mit.edu	37	2	97370351	97370351	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:97370351C>A	uc010fia.2	+	52	6204	c.6204C>A	c.(6202-6204)GAC>GAA	p.D2068E	FER1L5_uc002sws.3_Missense_Mutation_p.D777E|FER1L5_uc002swt.3_Missense_Mutation_p.D777E|FER1L5_uc010yus.1_Missense_Mutation_p.D776E	NM_001113382	NP_001106853	A0AVI2	FR1L5_HUMAN	fer-1-like 5 isoform 2	2068						integral to membrane				ovary(1)	1						CTACAATAGACCATGAGTGGA	0.463		NA											31	83					1.75e-11	3.19e-11	1	0
INPP4A	3631	broad.mit.edu	37	2	99179952	99179952	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:99179952C>T	uc002syy.2	+	19	2288	c.1895C>T	c.(1894-1896)CCG>CTG	p.P632L	INPP4A_uc010yvj.1_Missense_Mutation_p.P593L|INPP4A_uc010yvk.1_Missense_Mutation_p.P593L|INPP4A_uc002syx.2_Missense_Mutation_p.P627L|INPP4A_uc010fik.2_Intron	NM_001134224	NP_001127696	Q96PE3	INP4A_HUMAN	inositol polyphosphate-4-phosphatase, type 1	632					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			kidney(1)	1						GCCCTTTACCCGCTGCTGACC	0.532		NA											9	29					0	0	0	0
CREG2	200407	broad.mit.edu	37	2	102000150	102000150	+	Silent	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:102000150T>C	uc002tba.2	-	2	502	c.456A>G	c.(454-456)CCA>CCG	p.P152P		NM_153836	NP_722578	Q8IUH2	CREG2_HUMAN	cellular repressor of E1A-stimulated genes 2	152						extracellular region	FMN binding			ovary(1)	1						AGTTCCCAAATGGCAGTCCTT	0.512		NA											34	77					0	0	0	0
MFSD9	84804	broad.mit.edu	37	2	103353142	103353142	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:103353142C>G	uc002tcb.2	-	1	196	c.128G>C	c.(127-129)CGC>CCC	p.R43P	TMEM182_uc002tcc.3_5'Flank|TMEM182_uc002tcd.3_5'Flank|MFSD9_uc010fja.2_RNA	NM_032718	NP_116107	Q8NBP5	MFSD9_HUMAN	major facilitator superfamily domain containing	43					transmembrane transport	integral to membrane|plasma membrane	transporter activity			ovary(2)|breast(2)	4						CAGGAAGCGGCGGGCTCCGAC	0.672		NA											14	42					0	0	0	0
UXS1	80146	broad.mit.edu	37	2	106739524	106739524	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:106739524C>T	uc002tdm.2	-	9	744	c.646G>A	c.(646-648)GAG>AAG	p.E216K	UXS1_uc002tdl.2_Missense_Mutation_p.E48K|UXS1_uc002tdn.2_Missense_Mutation_p.E221K|UXS1_uc002tdo.2_Missense_Mutation_p.E159K|UXS1_uc010ywh.1_Missense_Mutation_p.E60K	NM_025076	NP_079352	Q8NBZ7	UXS1_HUMAN	UDP-glucuronate decarboxylase 1	216	Lumenal (Potential).				cellular metabolic process	Golgi cisterna membrane|integral to membrane	coenzyme binding|UDP-glucuronate decarboxylase activity			ovary(2)	2						CAGTAATCCTCACTTTGAGGG	0.453		NA											25	62					0	0	0	0
SULT1C3	442038	broad.mit.edu	37	2	108863754	108863754	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:108863754G>T	uc010ywo.1	+	1	104	c.104G>T	c.(103-105)TGG>TTG	p.W35L		NM_001008743	NP_001008743	Q6IMI6	ST1C3_HUMAN	sulfotransferase family, cytosolic, 1C, member	35						cytoplasm	alcohol sulfotransferase activity			skin(1)	1						TCAAAAGAATGGTGGGAAAAA	0.378		NA											18	53					3.99e-14	7.59e-14	1	0
FBLN7	129804	broad.mit.edu	37	2	112944822	112944822	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:112944822G>T	uc002tho.1	+	8	1330	c.1059G>T	c.(1057-1059)ACG>ACT	p.T353T	FBLN7_uc002thn.2_Intron|FBLN7_uc010fki.1_Silent_p.T307T|FBLN7_uc010fkj.1_Silent_p.T219T	NM_153214	NP_694946	Q53RD9	FBLN7_HUMAN	fibulin 7 isoform 1	353					cell adhesion	proteinaceous extracellular matrix	calcium ion binding|heparin binding			ovary(1)|central_nervous_system(1)	2						CGCCCATCACGCTCTTCCGCA	0.647		NA											38	103					4.14e-20	8.4e-20	1	0
SLC35F5	80255	broad.mit.edu	37	2	114503857	114503857	+	Silent	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:114503857A>T	uc002tku.1	-	5	901	c.477T>A	c.(475-477)TCT>TCA	p.S159S	SLC35F5_uc002tkt.2_RNA|SLC35F5_uc002tkv.2_Silent_p.S153S|SLC35F5_uc002tkw.2_Silent_p.S159S	NM_025181	NP_079457	Q8WV83	S35F5_HUMAN	solute carrier family 35, member F5	159					transport	integral to membrane					0						CACTTACCAAAGAACTATTCA	0.378		NA											16	39					0	0	0	0
STEAP3	55240	broad.mit.edu	37	2	120003239	120003239	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:120003239T>A	uc002tlp.2	+	3	324	c.167T>A	c.(166-168)GTG>GAG	p.V56E	STEAP3_uc002tlq.2_Missense_Mutation_p.V66E|STEAP3_uc002tlr.2_Missense_Mutation_p.V56E|STEAP3_uc010fle.2_Missense_Mutation_p.V56E	NM_018234	NP_060704	Q658P3	STEA3_HUMAN	dudulin 2 isoform b	56	Cytoplasmic (Potential).				apoptosis|cell cycle|cellular iron ion homeostasis|protein secretion|transferrin transport|transmembrane transport	endosome membrane|integral to membrane|multivesicular body	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			central_nervous_system(2)|skin(1)	3						AAAGTGGTGGTGGGGAGCCGC	0.637		NA											11	31					0	0	0	0
GLI2	2736	broad.mit.edu	37	2	121747847	121747847	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:121747847A>G	uc010flp.2	+	13	4387	c.4357A>G	c.(4357-4359)ATG>GTG	p.M1453V	GLI2_uc002tmq.1_Intron|GLI2_uc002tmr.1_Intron|GLI2_uc002tmt.3_Missense_Mutation_p.M1125V|GLI2_uc002tmu.3_Missense_Mutation_p.M1108V	NM_005270	NP_005261	P10070	GLI2_HUMAN	GLI-Kruppel family member GLI2	1453					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|lung(2)|breast(1)|central_nervous_system(1)|pancreas(1)	13	Renal(3;0.0496)	Prostate(154;0.0623)				CCAGATCCACATGTACGAACA	0.657		NA											24	64					0	0	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125175132	125175132	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:125175132T>C	uc002tno.2	+	4	858	c.494T>C	c.(493-495)ATT>ACT	p.I165T	CNTNAP5_uc010flu.2_Missense_Mutation_p.I165T	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	165	F5/8 type C.|Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		AGTGGGAAGATTGGCATGAGA	0.498		NA											3	16					0	0	0	0
FAM123C	205147	broad.mit.edu	37	2	131520349	131520349	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:131520349G>A	uc002trw.2	+	2	894	c.704G>A	c.(703-705)TGT>TAT	p.C235Y	FAM123C_uc010fmv.2_Missense_Mutation_p.C235Y|FAM123C_uc010fms.1_Missense_Mutation_p.C235Y|FAM123C_uc010fmt.1_Missense_Mutation_p.C235Y|FAM123C_uc010fmu.1_Missense_Mutation_p.C235Y	NM_152698	NP_689911	Q8N944	F123C_HUMAN	hypothetical protein LOC205147	235										pancreas(2)|ovary(1)	3	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.13)		AGGGCCCTGTGTGAGGACGTG	0.662		NA											26	130					0	0	0	0
NCKAP5	344148	broad.mit.edu	37	2	133540264	133540264	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:133540264G>C	uc002ttp.2	-	14	4494	c.4120C>G	c.(4120-4122)CCA>GCA	p.P1374A	NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	1374							protein binding				0						TCAGACTTTGGAGGGATCCTC	0.622		NA											15	30					0	0	0	0
ORC4L	5000	broad.mit.edu	37	2	148696734	148696734	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:148696734C>A	uc002twi.2	-	11	1068	c.933G>T	c.(931-933)ATG>ATT	p.M311I	ORC4L_uc002twj.2_Missense_Mutation_p.M311I|ORC4L_uc010zbo.1_Missense_Mutation_p.M237I|ORC4L_uc010zbp.1_Missense_Mutation_p.M94I|ORC4L_uc010fnr.2_Missense_Mutation_p.M311I|ORC4L_uc010zbq.1_Missense_Mutation_p.M227I|ORC4L_uc002twk.2_Missense_Mutation_p.M311I|ORC4L_uc010zbr.1_Missense_Mutation_p.M311I|ORC4L_uc002twl.1_5'Flank	NM_181741	NP_859525	O43929	ORC4_HUMAN	origin recognition complex subunit 4	311					cell cycle checkpoint|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	nuclear origin of replication recognition complex|nucleoplasm	ATP binding|DNA replication origin binding|nucleoside-triphosphatase activity|protein binding				0				BRCA - Breast invasive adenocarcinoma(221;0.0963)|COAD - Colon adenocarcinoma(177;0.203)		CTTTCGAGTCCATGCTACACA	0.358		NA											14	31					2.32e-09	4.08e-09	1	0
FAP	2191	broad.mit.edu	37	2	163027550	163027550	+	Missense_Mutation	SNP	G	G	T	rs138652824		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:163027550G>T	uc002ucd.2	-	26	2430	c.2222C>A	c.(2221-2223)ACG>AAG	p.T741K	FAP_uc010fpc.2_Missense_Mutation_p.T290K|FAP_uc010zct.1_Missense_Mutation_p.T716K|FAP_uc010fpd.2_Missense_Mutation_p.T220K	NM_004460	NP_004451	Q12884	SEPR_HUMAN	fibroblast activation protein, alpha subunit	741	Extracellular (Potential).				endothelial cell migration|negative regulation of extracellular matrix disassembly|proteolysis	cell junction|integral to membrane|invadopodium membrane|lamellipodium membrane	dipeptidyl-peptidase activity|metalloendopeptidase activity|protein homodimerization activity|serine-type endopeptidase activity	p.T741K(1)		ovary(3)	3						TAAGTGGTTCGTGGACAGGCC	0.433		NA											28	38					7.38e-10	1.31e-09	1	0
SCN3A	6328	broad.mit.edu	37	2	166019263	166019263	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:166019263C>A	uc002ucx.2	-	8	1262	c.770G>T	c.(769-771)TGT>TTT	p.C257F	SCN3A_uc002ucy.2_Missense_Mutation_p.C257F|SCN3A_uc002ucz.2_Missense_Mutation_p.C257F|SCN3A_uc002uda.1_Missense_Mutation_p.C126F|SCN3A_uc002udb.1_Missense_Mutation_p.C126F	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	257	Helical; Name=S5 of repeat I; (Potential).					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	CACGCTCAGACAGAACACAGT	0.478		NA											37	36					1.91e-15	3.71e-15	1	0
XIRP2	129446	broad.mit.edu	37	2	168105477	168105477	+	Silent	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:168105477A>T	uc002udx.2	+	8	7593	c.7575A>T	c.(7573-7575)CCA>CCT	p.P2525P	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Silent_p.P2350P|XIRP2_uc010fpq.2_Silent_p.P2303P|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2350					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						ATTCATTTCCAGAGAGTTCAG	0.348		NA											32	51					0	0	0	0
LRP2	4036	broad.mit.edu	37	2	170096254	170096254	+	Silent	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:170096254A>T	uc002ues.2	-	26	4290	c.4077T>A	c.(4075-4077)GGT>GGA	p.G1359G		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	1359	Extracellular (Potential).|EGF-like 5.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CGTGAGTACAACCACCATTGA	0.383		NA											17	27					0	0	0	0
SSB	6741	broad.mit.edu	37	2	170667535	170667535	+	Silent	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:170667535A>G	uc002ufk.2	+	10	1085	c.978A>G	c.(976-978)CTA>CTG	p.L326L	SSB_uc002ufl.2_Silent_p.L326L|SSB_uc002ufm.2_Silent_p.L326L	NM_003142	NP_003133	P05455	LA_HUMAN	autoantigen La	326					histone mRNA metabolic process|tRNA modification	nucleus|ribonucleoprotein complex	mRNA binding|nucleotide binding|protein binding|tRNA binding			skin(3)|pancreas(1)	4						AAGAATCCCTAAACAAATGGA	0.333		NA											14	27					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179392225	179392225	+	Silent	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:179392225A>G	uc010zfg.1	-	311	100148	c.99924T>C	c.(99922-99924)AAT>AAC	p.N33308N	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.N27003N|TTN_uc010zfi.1_Silent_p.N26936N|TTN_uc010zfj.1_Silent_p.N26811N|TTN_uc002umq.2_Intron	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	34235							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTTGTGTCATATTAGATATTC	0.403		NA											38	56					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179457788	179457788	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:179457788A>T	uc010zfg.1	-	249	51578	c.51354T>A	c.(51352-51354)AAT>AAA	p.N17118K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.N10813K|TTN_uc010zfi.1_Missense_Mutation_p.N10746K|TTN_uc010zfj.1_Missense_Mutation_p.N10621K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	18045							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGCTTCAGGATTAACAGGTG	0.358		NA											45	52					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179482516	179482516	+	Silent	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:179482516A>T	uc010zfg.1	-	202	40082	c.39858T>A	c.(39856-39858)GCT>GCA	p.A13286A	TTN_uc010zfh.1_Silent_p.A6981A|TTN_uc010zfi.1_Silent_p.A6914A|TTN_uc010zfj.1_Silent_p.A6789A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	14213							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAATTGGATCAGCAACTTTGA	0.388		NA											17	35					0	0	0	0
COL3A1	1281	broad.mit.edu	37	2	189854843	189854843	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:189854843C>A	uc002uqj.1	+	9	829	c.712C>A	c.(712-714)CGA>AGA	p.R238R	COL3A1_uc010frw.1_5'Flank	NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	238	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	TAGACCCGGACGACCTGGAGA	0.383		NA											13	23					0.00244969	0.00356876	1	0
PLCL1	5334	broad.mit.edu	37	2	198950550	198950550	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:198950550A>T	uc010fsp.2	+	2	2600	c.2309A>T	c.(2308-2310)CAG>CTG	p.Q770L	PLCL1_uc002uuv.3_Missense_Mutation_p.Q691L	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	770	C2.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	AAAACTGTACAGCAAAACAGT	0.408		NA											20	37					0	0	0	0
CASP8	841	broad.mit.edu	37	2	202137359	202137359	+	Splice_Site	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:202137359A>G	uc002uxr.1	+	5	621	c.412_splice	c.e5-2	p.N138_splice	CASP8_uc010ftc.1_Splice_Site_p.N138_splice|CASP8_uc002uxo.1_Splice_Site_p.N138_splice|CASP8_uc002uxp.1_Splice_Site_p.N170_splice|CASP8_uc002uxq.1_Splice_Site_p.N138_splice|CASP8_uc002uxs.1_Splice_Site_p.N138_splice|CASP8_uc002uxt.1_Splice_Site_p.N197_splice|CASP8_uc002uxu.1_Splice_Site|CASP8_uc010ftd.1_Splice_Site_p.N35_splice|CASP8_uc002uxv.1_Splice_Site_p.N138_splice|CASP8_uc002uxw.1_Splice_Site_p.N138_splice|CASP8_uc002uxy.1_Splice_Site_p.N138_splice|CASP8_uc002uxx.1_Splice_Site_p.N138_splice|CASP8_uc010ftf.2_Splice_Site_p.N138_splice|CASP8_uc010fte.1_Splice_Site_p.N35_splice	NM_033355	NP_203519	Q14790	CASP8_HUMAN	caspase 8 isoform B precursor						activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding			upper_aerodigestive_tract(2)|ovary(1)|breast(1)|skin(1)	5						TCCTCCTCTTAGAACCTGCTG	0.408		NA								HNSCC(4;0.00038)			27	52					0	0	0	0
ZDBF2	57683	broad.mit.edu	37	2	207176110	207176110	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:207176110G>T	uc002vbp.2	+	5	7108	c.6858G>T	c.(6856-6858)ATG>ATT	p.M2286I		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	2286							nucleic acid binding|zinc ion binding			ovary(3)	3						CAAGCGCTATGGCAAATCCTC	0.507		NA											8	4					0.000274275	0.000411185	1	0
IDH1	3417	broad.mit.edu	37	2	209116227	209116227	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:209116227C>T	uc002vcs.2	-	3	295	c.49G>A	c.(49-51)GAA>AAA	p.E17K	IDH1_uc002vct.2_Missense_Mutation_p.E17K|IDH1_uc002vcu.2_Missense_Mutation_p.E17K	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	17					2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity			central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		CGTGTCATTTCATCTCCTTGC	0.358		NA	Mis		gliobastoma 								27	31					0	0	0	0
PTH2R	5746	broad.mit.edu	37	2	209308084	209308084	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:209308084G>A	uc002vdb.2	+	6	734	c.521G>A	c.(520-522)TGC>TAC	p.C174Y	PTH2R_uc010zjb.1_Missense_Mutation_p.C185Y	NM_005048	NP_005039	P49190	PTH2R_HUMAN	parathyroid hormone 2 receptor precursor	174	Cytoplasmic (Potential).					integral to plasma membrane	parathyroid hormone receptor activity			ovary(1)|breast(1)|skin(1)	3				Epithelial(149;0.0684)|Lung(261;0.0785)|LUSC - Lung squamous cell carcinoma(261;0.0836)		CGATTGCATTGCACTAGGAAC	0.418		NA											17	20					0	0	0	0
ACADL	33	broad.mit.edu	37	2	211085399	211085399	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:211085399G>T	uc002vdz.3	-	2	433	c.205C>A	c.(205-207)CAA>AAA	p.Q69K	ACADL_uc010zjg.1_Missense_Mutation_p.Q69K	NM_001608	NP_001599	P28330	ACADL_HUMAN	long-chain acyl-CoA dehydrogenase precursor	69					carnitine catabolic process|carnitine metabolic process, CoA-linked|fatty acid beta-oxidation using acyl-CoA dehydrogenase|negative regulation of fatty acid biosynthetic process|negative regulation of fatty acid oxidation|regulation of cholesterol metabolic process|temperature homeostasis	mitochondrial matrix	long-chain-acyl-CoA dehydrogenase activity|palmitoyl-CoA oxidase activity				0		Renal(323;0.202)		Epithelial(149;0.00631)|Lung(261;0.0438)|LUSC - Lung squamous cell carcinoma(261;0.0466)|all cancers(144;0.0621)		ACTTCTTCTTGGAAAAACTTC	0.358		NA											18	23					1.01e-13	1.91e-13	1	0
ABCA12	26154	broad.mit.edu	37	2	215976318	215976318	+	Splice_Site	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:215976318A>T	uc002vew.2	-	2	383	c.163_splice	c.e2+1	p.C55_splice	ABCA12_uc010zjn.1_Splice_Site	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12						cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		TCATTTACTTACAAGTTGGTT	0.294		NA											19	22					0	0	0	0
ANKZF1	55139	broad.mit.edu	37	2	220095004	220095004	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:220095004C>T	uc002vkg.2	+	2	199	c.25C>T	c.(25-27)CCG>TCG	p.P9S	ATG9A_uc002vke.1_5'Flank|ATG9A_uc002vkf.1_5'Flank|ANKZF1_uc010zkv.1_Missense_Mutation_p.P9S|ANKZF1_uc010zkw.1_Intron|ANKZF1_uc002vkh.2_Intron|ANKZF1_uc002vki.2_Missense_Mutation_p.P9S|ANKZF1_uc002vkj.1_5'Flank	NM_018089	NP_060559	Q9H8Y5	ANKZ1_HUMAN	ankyrin repeat and zinc finger domain containing	9						intracellular	zinc ion binding			ovary(2)	2		Renal(207;0.0474)		Epithelial(149;1.2e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGATGCAGCCCCGGCTCCTGC	0.612		NA											11	22					0	0	0	0
DOCK10	55619	broad.mit.edu	37	2	225639746	225639746	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:225639746G>T	uc010fwz.1	-	52	6128	c.5889C>A	c.(5887-5889)GAC>GAA	p.D1963E	DOCK10_uc002vob.2_Missense_Mutation_p.D1957E|DOCK10_uc002voa.2_Missense_Mutation_p.D619E	NM_014689	NP_055504	Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	1963	DHR-2.						GTP binding			ovary(2)	2		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		CTGTCTTCCGGTCTTCGATTT	0.507		NA											7	14					8.13e-05	0.000124651	1	0
SPHKAP	80309	broad.mit.edu	37	2	228881633	228881633	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:228881633A>C	uc002vpq.2	-	7	3984	c.3937T>G	c.(3937-3939)TCC>GCC	p.S1313A	SPHKAP_uc002vpp.2_Missense_Mutation_p.S1313A|SPHKAP_uc010zlx.1_Missense_Mutation_p.S1313A	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	1313						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GCCTCAATGGAGCTAGCCCAC	0.507		NA											17	27					0	0	0	0
CHGB	1114	broad.mit.edu	37	20	5903868	5903868	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:5903868G>A	uc002wmg.2	+	4	1384	c.1078G>A	c.(1078-1080)GAG>AAG	p.E360K	CHGB_uc010zqz.1_Missense_Mutation_p.E43K	NM_001819	NP_001810	P05060	SCG1_HUMAN	chromogranin B precursor	360						extracellular region	hormone activity			breast(3)|skin(2)|ovary(1)	6						CCTGGAGTGGGAGCGCTATAG	0.527		NA											33	94					0	0	0	0
HAO1	54363	broad.mit.edu	37	20	7915261	7915261	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:7915261C>G	uc002wmw.1	-	2	183	c.159G>C	c.(157-159)ATG>ATC	p.M53I	HAO1_uc010gbu.2_Missense_Mutation_p.M53I	NM_017545	NP_060015	Q9UJM8	HAOX1_HUMAN	hydroxyacid oxidase 1	53	FMN hydroxy acid dehydrogenase.				cellular nitrogen compound metabolic process|fatty acid alpha-oxidation|glycolate catabolic process|glyoxylate metabolic process	peroxisomal matrix	FMN binding|glycolate oxidase activity|glyoxylate oxidase activity			ovary(3)	3						CATTCCGGAGCATCCTTGGAT	0.403		NA											24	54					0	0	0	0
FLRT3	23767	broad.mit.edu	37	20	14306911	14306911	+	Silent	SNP	A	A	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:14306911A>C	uc002wov.1	-	3	1709	c.1242T>G	c.(1240-1242)ACT>ACG	p.T414T	MACROD2_uc002wot.2_Intron|MACROD2_uc002wou.2_Intron|FLRT3_uc002wow.1_Silent_p.T414T	NM_198391	NP_938205	Q9NZU0	FLRT3_HUMAN	fibronectin leucine rich transmembrane protein 3	414	Extracellular (Potential).|Fibronectin type-III.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			kidney(1)	1		Colorectal(1;0.0464)	COAD - Colon adenocarcinoma(2;0.129)	Colorectal(1;0.0393)		CAGACTTCACAGTAATTGTAA	0.468		NA											46	117					0	0	0	0
PCSK2	5126	broad.mit.edu	37	20	17446125	17446125	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:17446125G>A	uc002wpm.2	+	11	1677	c.1357G>A	c.(1357-1359)GTG>ATG	p.V453M	PCSK2_uc002wpl.2_Missense_Mutation_p.V434M|PCSK2_uc010zrm.1_Missense_Mutation_p.V418M|PCSK2_uc002wpn.2_Missense_Mutation_p.V107M	NM_002594	NP_002585	P16519	NEC2_HUMAN	proprotein convertase subtilisin/kexin type 2	453					enkephalin processing|insulin processing|islet amyloid polypeptide processing	extracellular space|membrane|soluble fraction|transport vesicle	serine-type endopeptidase activity			ovary(3)|central_nervous_system(2)|large_intestine(1)|pancreas(1)	7					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	AGGTGCCATGGTGAAAATGGC	0.567		NA											10	20					0	0	0	0
DTD1	92675	broad.mit.edu	37	20	18724787	18724787	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:18724787G>T	uc002wrf.3	+	5	682	c.521G>T	c.(520-522)AGA>ATA	p.R174I		NM_080820	NP_543010	Q8TEA8	DTD1_HUMAN	D-tyrosyl-tRNA deacylase 1	174					D-amino acid catabolic process	cytoplasm	hydrolase activity, acting on ester bonds			ovary(2)	2						GAAAAGACCAGAGCTAAGGGA	0.443		NA											12	17					3.07e-06	4.97e-06	1	0
FOXA2	3170	broad.mit.edu	37	20	22563227	22563227	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:22563227G>A	uc002wsn.2	-	3	825	c.635C>T	c.(634-636)TCC>TTC	p.S212F	FOXA2_uc002wsm.2_Missense_Mutation_p.S218F	NM_153675	NP_710141	Q9Y261	FOXA2_HUMAN	forkhead box A2 isoform 2	212	Fork-head.				cell differentiation in hindbrain|central nervous system myelin formation|chromatin modification|dorsal/ventral neural tube patterning|ectoderm formation|endocrine pancreas development|endoderm development|epithelial tube branching involved in lung morphogenesis|in utero embryonic development|lung epithelial cell differentiation|negative regulation of neuron differentiation|neuron fate specification|oligodendrocyte cell fate commitment|positive regulation of embryonic development|positive regulation of gastrulation|positive regulation of neuron differentiation|primitive streak formation|regulation of blood coagulation|regulation of sequence-specific DNA binding transcription factor activity|response to interleukin-6	cytoplasm|transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)|kidney(1)|central_nervous_system(1)	4	Lung NSC(19;0.188)					GTCGTTGAAGGAGAGCGAGTG	0.607		NA											15	37					0	0	0	0
SSTR4	6754	broad.mit.edu	37	20	23017238	23017238	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:23017238C>A	uc002wsr.2	+	1	1182	c.1118C>A	c.(1117-1119)CCA>CAA	p.P373Q		NM_001052	NP_001043	P31391	SSR4_HUMAN	somatostatin receptor 4	373	Cytoplasmic (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			ovary(1)	1	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)					GCCCTGCAACCAGAACCCGGC	0.667		NA											24	59					1.04e-07	1.76e-07	1	0
THBD	7056	broad.mit.edu	37	20	23029284	23029284	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:23029284C>A	uc002wss.2	-	1	1018	c.858G>T	c.(856-858)CAG>CAT	p.Q286H	THBD_uc002wst.1_5'Flank|THBD_uc002wsu.1_Missense_Mutation_p.Q227H	NM_000361	NP_000352	P07204	TRBM_HUMAN	thrombomodulin precursor	286	EGF-like 2.|Extracellular (Potential).				blood coagulation|leukocyte migration|negative regulation of fibrinolysis|negative regulation of platelet activation	cell surface|integral to plasma membrane	calcium ion binding|protein binding|transmembrane receptor activity				0	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)				Drotrecogin alfa(DB00055)	CGTTGCAGGACTGCGTCGCGG	0.716		NA											10	15					0.000442599	0.000662431	1	0
CD93	22918	broad.mit.edu	37	20	23064994	23064994	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:23064994C>G	uc002wsv.2	-	1	1984	c.1836G>C	c.(1834-1836)AAG>AAC	p.K612N		NM_012072	NP_036204	Q9NPY3	C1QR1_HUMAN	CD93 antigen precursor	612	Cytoplasmic (Potential).				cell-cell adhesion|interspecies interaction between organisms|macrophage activation|phagocytosis	plasma membrane	calcium ion binding|complement component C1q binding|receptor activity|sugar binding			large_intestine(2)	2	Colorectal(13;0.0352)|Lung NSC(19;0.0542)|all_lung(19;0.118)					TCTCCTCCCTCTTCGCTCTCC	0.567		NA											52	149					0	0	0	0
CST8	10047	broad.mit.edu	37	20	23476506	23476506	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:23476506G>C	uc002wth.1	+	4	741	c.384G>C	c.(382-384)TGG>TGC	p.W128C		NM_005492	NP_005483	O60676	CST8_HUMAN	cystatin 8 precursor	128						extracellular region	cysteine-type endopeptidase inhibitor activity				0	Colorectal(13;0.0431)|Lung NSC(19;0.235)					CACTTCCCTGGAATGGTGAAT	0.348		NA											26	48					0	0	0	0
CST5	1473	broad.mit.edu	37	20	23860133	23860133	+	Nonsense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:23860133T>A	uc002wtr.1	-	1	248	c.181A>T	c.(181-183)AAG>TAG	p.K61*		NM_001900	NP_001891	P28325	CYTD_HUMAN	cystatin D precursor	61						extracellular region	cysteine-type endopeptidase inhibitor activity|protein binding				0						TACTCATCCTTATTAATGACC	0.557		NA											70	224					0	0	0	0
ACSS1	84532	broad.mit.edu	37	20	24995843	24995843	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:24995843C>A	uc002wub.2	-	8	2148	c.1270G>T	c.(1270-1272)GCC>TCC	p.A424S	ACSS1_uc002wuc.2_Missense_Mutation_p.A424S|ACSS1_uc010gdc.2_Missense_Mutation_p.A219S|ACSS1_uc002wud.1_RNA|ACSS1_uc002wua.2_Missense_Mutation_p.A341S	NM_032501	NP_115890	Q9NUB1	ACS2L_HUMAN	acyl-CoA synthetase short-chain family member 1	424					acetyl-CoA biosynthetic process|ethanol oxidation|xenobiotic metabolic process	mitochondrial matrix	acetate-CoA ligase activity|AMP binding|ATP binding|protein binding			ovary(1)|skin(1)	2					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	CACTCCCAGGCCTCACAGTTG	0.522		NA											20	39					7.42e-09	1.28e-08	1	0
BPIL1	80341	broad.mit.edu	37	20	31601615	31601615	+	Splice_Site	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:31601615G>T	uc002wyj.2	+	5	503	c.309_splice	c.e5-1	p.R103_splice		NM_025227	NP_079503	Q8N4F0	BPIL1_HUMAN	bactericidal/permeability-increasing							extracellular region	lipid binding			skin(2)|large_intestine(1)|ovary(1)	4						CATCCCTACAGCGCCCCAGAG	0.637		NA											18	58					3.33e-07	5.55e-07	1	0
BPIL1	80341	broad.mit.edu	37	20	31601640	31601640	+	Silent	SNP	G	G	C	rs148455522	byFrequency	TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:31601640G>C	uc002wyj.2	+	5	527	c.333G>C	c.(331-333)ACG>ACC	p.T111T		NM_025227	NP_079503	Q8N4F0	BPIL1_HUMAN	bactericidal/permeability-increasing	111						extracellular region	lipid binding			skin(2)|large_intestine(1)|ovary(1)	4						TGGAGCTGACGCTGCCTGTGG	0.617		NA											10	54					0	0	0	0
GSS	2937	broad.mit.edu	37	20	33519801	33519801	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:33519801G>T	uc002xbg.2	-	10	1050	c.970C>A	c.(970-972)CAG>AAG	p.Q324K	GSS_uc010zun.1_Missense_Mutation_p.Q196K|GSS_uc010zuo.1_Missense_Mutation_p.Q213K|GSS_uc010zup.1_Missense_Mutation_p.Q255K|GSS_uc002xbh.2_RNA|GSS_uc010gez.1_Missense_Mutation_p.Q54K	NM_000178	NP_000169	P48637	GSHB_HUMAN	glutathione synthetase	324					nervous system development|response to oxidative stress|xenobiotic metabolic process	cytosol	ATP binding|glutathione binding|glutathione synthase activity|magnesium ion binding|protein homodimerization activity			ovary(3)	3			BRCA - Breast invasive adenocarcinoma(18;0.035)		Glutathione(DB00143)|Glycine(DB00145)|L-Cysteine(DB00151)	GCCTCAGGCTGGCCAGGGAGC	0.632		NA											51	72					1.36e-18	2.74e-18	1	0
LBP	3929	broad.mit.edu	37	20	36993246	36993246	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:36993246G>A	uc002xic.1	+	8	796	c.761G>A	c.(760-762)CGT>CAT	p.R254H		NM_004139	NP_004130	P18428	LBP_HUMAN	lipopolysaccharide-binding protein precursor	254					acute-phase response|cellular defense response|cellular response to lipoteichoic acid|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|detection of molecule of bacterial origin|innate immune response|lipid transport|lipopolysaccharide transport|lipopolysaccharide-mediated signaling pathway|macrophage activation involved in immune response|negative regulation of tumor necrosis factor production|opsonization|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of macrophage activation|positive regulation of respiratory burst involved in inflammatory response|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of tumor necrosis factor production|Toll signaling pathway	extracellular space	Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|lipid binding|lipopolysaccharide binding|lipoteichoic acid binding|receptor binding			ovary(1)|central_nervous_system(1)	2		Myeloproliferative disorder(115;0.00878)				ATCTTTCATCGTAACCACCGT	0.488		NA											38	61					0	0	0	0
PTPRT	11122	broad.mit.edu	37	20	41306563	41306563	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:41306563C>A	uc002xkg.2	-	7	1280	c.1096G>T	c.(1096-1098)GGT>TGT	p.G366C	PTPRT_uc010ggj.2_Missense_Mutation_p.G366C	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	366	Extracellular (Potential).|Fibronectin type-III 1.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity	p.G366V(1)		skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				CCCCCCTCACCTGGTCGTGTG	0.562		NA											32	38					2.85e-18	5.71e-18	1	0
MYBL2	4605	broad.mit.edu	37	20	42328423	42328423	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:42328423C>T	uc002xlb.1	+	7	905	c.690C>T	c.(688-690)TCC>TCT	p.S230S	MYBL2_uc010zwj.1_Silent_p.S206S|MYBL2_uc002xla.1_Silent_p.S230S	NM_002466	NP_002457	P10244	MYBB_HUMAN	MYB-related protein B	230						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(3)|kidney(2)	5		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			ACTGGCCCTCCGTCCCTCCTA	0.443		NA											16	28					0	0	0	0
C20orf85	128602	broad.mit.edu	37	20	56735866	56735866	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:56735866G>T	uc002xyv.2	+	4	440	c.402G>T	c.(400-402)CAG>CAT	p.Q134H		NM_178456	NP_848551	Q9H1P6	CT085_HUMAN	hypothetical protein LOC128602	134										ovary(1)	1	all_epithelial(3;5.99e-14)|Lung NSC(12;0.000152)|all_lung(29;0.000518)|Melanoma(10;0.118)		BRCA - Breast invasive adenocarcinoma(13;5.53e-12)|Epithelial(14;7.42e-08)|all cancers(14;7.19e-07)			GGCCCAAGCAGGGCGTGCACT	0.597		NA											11	14					3.07e-06	4.97e-06	1	0
NPEPL1	79716	broad.mit.edu	37	20	57268861	57268861	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:57268861C>T	uc010zzs.1	+	2	314	c.219C>T	c.(217-219)TAC>TAT	p.Y73Y	NPEPL1_uc010zzr.1_Silent_p.Y25Y|NPEPL1_uc002xzn.2_RNA|NPEPL1_uc010gjo.1_Silent_p.Y45Y|NPEPL1_uc002xzp.2_Translation_Start_Site	NM_024663	NP_078939	Q8NDH3	PEPL1_HUMAN	aminopeptidase-like 1	73					proteolysis	cytoplasm	aminopeptidase activity|manganese ion binding|metalloexopeptidase activity				0	all_lung(29;0.0175)		BRCA - Breast invasive adenocarcinoma(13;2.88e-09)|Colorectal(105;0.109)			ACCTGAACTACGCCACCGTGG	0.672		NA											29	34					0	0	0	0
PHACTR3	116154	broad.mit.edu	37	20	58330273	58330273	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:58330273C>T	uc002yau.2	+	4	862	c.395C>T	c.(394-396)CCC>CTC	p.P132L	PHACTR3_uc002yat.2_Missense_Mutation_p.P129L|PHACTR3_uc010zzw.1_Missense_Mutation_p.P91L|PHACTR3_uc002yav.2_Missense_Mutation_p.P91L|PHACTR3_uc002yaw.2_Missense_Mutation_p.P91L|PHACTR3_uc002yax.2_Missense_Mutation_p.P91L	NM_080672	NP_542403	Q96KR7	PHAR3_HUMAN	phosphatase and actin regulator 3 isoform 1	132						nuclear matrix	actin binding|protein phosphatase inhibitor activity			ovary(2)|pancreas(1)	3	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;2.76e-09)			GATGGAGGACCCCGATCTGTA	0.587		NA											9	17					0	0	0	0
DIDO1	11083	broad.mit.edu	37	20	61525097	61525097	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:61525097C>A	uc002ydr.1	-	12	3286	c.3022G>T	c.(3022-3024)GTG>TTG	p.V1008L	DIDO1_uc002yds.1_Missense_Mutation_p.V1008L|DIDO1_uc002ydt.1_Missense_Mutation_p.V1008L|DIDO1_uc002ydu.1_Missense_Mutation_p.V1008L	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	1008					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					GACTTGGGCACCATCACAGAA	0.557		NA											39	53					2.05e-20	4.17e-20	1	0
MYT1	4661	broad.mit.edu	37	20	62830234	62830234	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr20:62830234A>T	uc002yii.2	+	3	384	c.20A>T	c.(19-21)GAC>GTC	p.D7V	MYT1_uc002yih.2_Missense_Mutation_p.D7V	NM_004535	NP_004526	Q01538	MYT1_HUMAN	myelin transcription factor 1	7					cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					GAAAATGAAGACAAGCGAGCT	0.557		NA											11	29					0	0	0	0
HSPA13	6782	broad.mit.edu	37	21	15746151	15746151	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr21:15746151C>A	uc002yjt.2	-	5	1272	c.1203G>T	c.(1201-1203)GAG>GAT	p.E401D	HSPA13_uc011abx.1_Missense_Mutation_p.E193D	NM_006948	NP_008879	P48723	HSP13_HUMAN	heat shock protein 70kDa family member 13	401						endoplasmic reticulum|microsome	ATP binding			kidney(1)	1						CTAAAACCACCTCATCAATCT	0.438		NA											55	85					2.31e-15	4.5e-15	1	0
SAMSN1	64092	broad.mit.edu	37	21	15872886	15872886	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr21:15872886C>A	uc002yju.1	-	6	814	c.732G>T	c.(730-732)AAG>AAT	p.K244N	SAMSN1_uc010gky.1_Missense_Mutation_p.K76N|SAMSN1_uc002yjv.1_Missense_Mutation_p.K312N	NM_022136	NP_071419	Q9NSI8	SAMN1_HUMAN	SAM domain, SH3 domain and nuclear localization	244	SAM.				negative regulation of adaptive immune response|negative regulation of B cell activation|negative regulation of peptidyl-tyrosine phosphorylation	cytoplasm|nucleus|ruffle	phosphotyrosine binding			ovary(3)|pancreas(1)	4				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.00118)|Colorectal(24;0.00961)|Lung(58;0.164)		CCTGCAGAGTCTTGGATTTTT	0.433		NA											10	57					2.81e-09	4.9e-09	1	0
ADAMTS5	11096	broad.mit.edu	37	21	28338577	28338577	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr21:28338577C>T	uc002ymg.2	-	1	863	c.134G>A	c.(133-135)CGG>CAG	p.R45Q		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1	45					proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						CCCCTGCCGCCGGCGGGGCTG	0.766		NA											7	13					0	0	0	0
KRTAP13-3	337960	broad.mit.edu	37	21	31797760	31797760	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr21:31797760C>T	uc002yob.1	-	1	471	c.471G>A	c.(469-471)TGG>TGA	p.W157*		NM_181622	NP_853653	Q3SY46	KR133_HUMAN	keratin associated protein 13-3	157						intermediate filament				ovary(1)|lung(1)	2						ATGAATGGAACCACCTTCTAG	0.388		NA											19	28					0	0	0	0
SFRS15	57466	broad.mit.edu	37	21	33064243	33064243	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr21:33064243T>C	uc002ypd.2	-	14	2041	c.1615A>G	c.(1615-1617)ATG>GTG	p.M539V	SFRS15_uc002ype.2_Missense_Mutation_p.M539V|SFRS15_uc010glu.2_Missense_Mutation_p.M524V|SFRS15_uc002ypf.1_Missense_Mutation_p.M213V	NM_020706	NP_065757	O95104	SFR15_HUMAN	splicing factor, arginine/serine-rich 15 isoform	539	RRM.					nucleus	nucleotide binding|RNA binding				0						GGAGGAATCATCTGCTCCAAA	0.408		NA											17	52					0	0	0	0
AIRE	326	broad.mit.edu	37	21	45708269	45708269	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr21:45708269A>T	uc002zei.2	+	5	707	c.580A>T	c.(580-582)ATG>TTG	p.M194L	AIRE_uc010gpq.2_5'Flank|AIRE_uc002zej.2_5'Flank|AIRE_uc010gpr.2_5'Flank	NM_000383	NP_000374	O43918	AIRE_HUMAN	autoimmune regulator isoform 1	194	SAND.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|histone binding|transcription regulatory region DNA binding|translation regulator activity|zinc ion binding			skin(1)	1				Colorectal(79;0.0806)		AGCTGTGGCCATGTCCTCCGG	0.622		NA							Autoimmune_PolyEndocrinopathy_Candidiasis_Ectodermal_Dystrophy				37	71					0	0	0	0
COL6A1	1291	broad.mit.edu	37	21	47421935	47421935	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr21:47421935C>T	uc002zhu.1	+	31	2119	c.2017C>T	c.(2017-2019)CAC>TAC	p.H673Y	COL6A1_uc010gqd.1_Missense_Mutation_p.H4Y|COL6A1_uc002zhv.1_Missense_Mutation_p.H4Y|COL6A1_uc002zhw.1_5'Flank	NM_001848	NP_001839	P12109	CO6A1_HUMAN	collagen, type VI, alpha 1 precursor	673	VWFA 2.|C-terminal globular domain.				axon guidance|cell adhesion|protein heterotrimerization	collagen type VI|protein complex	platelet-derived growth factor binding			ovary(1)	1	all_hematologic(128;0.24)			Colorectal(79;0.0265)|READ - Rectum adenocarcinoma(84;0.0649)	Palifermin(DB00039)	GATGCAGGAGCACGTGAGCCT	0.697		NA											14	38					0	0	0	0
PCNT	5116	broad.mit.edu	37	21	47851899	47851899	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr21:47851899G>T	uc002zji.3	+	38	8628	c.8521G>T	c.(8521-8523)GCC>TCC	p.A2841S	PCNT_uc002zjj.2_Intron	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	2841	Potential.				cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					GGAGGTAAGTGCCACACTGAA	0.567		NA											17	39					1.78e-19	3.61e-19	1	0
POTEH	23784	broad.mit.edu	37	22	16279270	16279270	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr22:16279270T>C	uc010gqp.2	-	4	1005	c.953A>G	c.(952-954)CAT>CGT	p.H318R	POTEH_uc002zlg.1_RNA|POTEH_uc002zlh.1_Missense_Mutation_p.H37R|POTEH_uc002zlj.1_Missense_Mutation_p.H153R	NM_001136213	NP_001129685	Q6S545	POTEH_HUMAN	ANKRD26-like family C, member 3	318	ANK 5.									skin(1)	1						TTTTTGCTCATGTACACCAAG	0.328		NA											28	418					0	0	0	0
CCT8L2	150160	broad.mit.edu	37	22	17072618	17072618	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr22:17072618C>G	uc002zlp.1	-	1	1083	c.823G>C	c.(823-825)GAT>CAT	p.D275H		NM_014406	NP_055221	Q96SF2	TCPQM_HUMAN	T-complex protein 1	275					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			ovary(1)	1	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				AGTAATTGATCGCTTCCTTTA	0.527		NA											49	141					0	0	0	0
CCT8L2	150160	broad.mit.edu	37	22	17073049	17073049	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr22:17073049T>A	uc002zlp.1	-	1	652	c.392A>T	c.(391-393)CAG>CTG	p.Q131L		NM_014406	NP_055221	Q96SF2	TCPQM_HUMAN	T-complex protein 1	131					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			ovary(1)	1	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				CTCCCGGAGCTGCGGGCGAGG	0.652		NA											15	41					0	0	0	0
TOP3B	8940	broad.mit.edu	37	22	22322027	22322027	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr22:22322027C>G	uc002zvs.2	-	8	1235	c.800G>C	c.(799-801)CGG>CCG	p.R267P	TOP3B_uc010gtm.1_5'UTR|TOP3B_uc002zvr.2_5'UTR|TOP3B_uc010gtl.2_Missense_Mutation_p.R267P|TOP3B_uc002zvt.3_Missense_Mutation_p.R267P	NM_003935	NP_003926	O95985	TOP3B_HUMAN	topoisomerase (DNA) III beta	267					DNA topological change	nucleus	ATP binding|DNA topoisomerase type I activity|protein binding			kidney(1)	1	Colorectal(54;0.105)			READ - Rectum adenocarcinoma(21;0.145)		TGCGATCTCCCGGTCAAACAC	0.483		NA											33	65					0	0	0	0
CABIN1	23523	broad.mit.edu	37	22	24480531	24480531	+	Splice_Site	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr22:24480531G>T	uc002zzi.1	+	21	3038	c.2911_splice	c.e21-1	p.V971_splice	CABIN1_uc002zzj.1_Splice_Site_p.V921_splice|CABIN1_uc002zzl.1_Splice_Site_p.V971_splice	NM_012295	NP_036427	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1						cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						TTTTTTTCAAGGTGGATCTTA	0.408		NA											31	96					2.08e-15	4.05e-15	1	0
CHEK2	11200	broad.mit.edu	37	22	29083962	29083962	+	Missense_Mutation	SNP	G	G	C	rs138839489	by1000genomes	TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr22:29083962G>C	uc003adu.1	-	15	1627	c.1555C>G	c.(1555-1557)CGA>GGA	p.R519G	CHEK2_uc003ads.1_Missense_Mutation_p.R298G|CHEK2_uc010gvh.1_Missense_Mutation_p.R428G|CHEK2_uc010gvi.1_Missense_Mutation_p.R368G|CHEK2_uc010gvj.1_RNA|CHEK2_uc003adr.1_RNA|CHEK2_uc010gvk.1_RNA|CHEK2_uc003adt.1_Missense_Mutation_p.R562G|CHEK2_uc003adv.1_Missense_Mutation_p.R490G|CHEK2_uc003adw.1_Missense_Mutation_p.R519G|CHEK2_uc003adx.1_Missense_Mutation_p.R298G|CHEK2_uc003ady.1_Missense_Mutation_p.R508G|CHEK2_uc003adz.1_Missense_Mutation_p.R323G	NM_007194	NP_009125	O96017	CHK2_HUMAN	protein kinase CHK2 isoform a	519					cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(17)|stomach(1)|ovary(1)|lung(1)	20						GGCCGCTTTCGACTAGTAGAA	0.463		NA	F			breast 		Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes	Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|CHEK2-associated_cancer				3	31					0	0	0	0
EWSR1	2130	broad.mit.edu	37	22	29684679	29684679	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr22:29684679G>C	uc003aet.2	+	8	1206	c.878G>C	c.(877-879)AGC>ACC	p.S293T	EWSR1_uc003aes.3_Missense_Mutation_p.S293T|EWSR1_uc003aev.2_Missense_Mutation_p.S299T|EWSR1_uc003aew.2_Missense_Mutation_p.S237T|EWSR1_uc003aex.2_Missense_Mutation_p.S293T|EWSR1_uc003aey.2_Missense_Mutation_p.S88T|EWSR1_uc003aez.2_5'Flank	NM_005243	NP_005234	Q01844	EWS_HUMAN	Ewing sarcoma breakpoint region 1 isoform 2	293					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	calmodulin binding|nucleotide binding|RNA binding|zinc ion binding		EWSR1/FLI1(2266)|EWSR1/ATF1(323)|EWSR1/WT1(231)|EWSR1/ERG(162)|EWSR1/NR4A3(140)|EWSR1/DDIT3(43)|EWSR1/CREB1(42)|EWSR1/FEV(10)|EWSR1/POU5F1(10)|EWSR1/ETV1(7)|EWSR1/ETV4(6)|EWSR1/ZNF384(4)|EWSR1/PBX1(3)|EWSR1/SP3(3)|EWSR1/PATZ1(2)	bone(2526)|soft_tissue(702)|skin(8)|autonomic_ganglia(4)|haematopoietic_and_lymphoid_tissue(4)|salivary_gland(2)|central_nervous_system(2)|NS(2)|pancreas(2)|lung(1)|ovary(1)	3254						GAGAACCGGAGCATGAGTGGC	0.592		NA	T	FLI1|ERG|ZNF278|NR4A3|FEV|ATF1|ETV1|ETV4|WT1|ZNF384|CREB1|POU5F1| PBX1	Ewing sarcoma| desmoplastic small round cell tumor |ALL|clear cell sarcoma|sarcoma|myoepithelioma								18	25					0	0	0	0
SFI1	9814	broad.mit.edu	37	22	31946321	31946321	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr22:31946321A>T	uc003ale.2	+	6	924	c.531A>T	c.(529-531)AGA>AGT	p.R177S	SFI1_uc003ald.1_Missense_Mutation_p.R153S|SFI1_uc003alf.2_Missense_Mutation_p.R177S|SFI1_uc003alg.2_Missense_Mutation_p.R95S|SFI1_uc011alp.1_Missense_Mutation_p.R95S|SFI1_uc011alq.1_Missense_Mutation_p.R153S|SFI1_uc003alh.2_Intron	NM_001007467	NP_001007468	A8K8P3	SFI1_HUMAN	spindle assembly associated Sfi1 homolog isoform	177	HAT 2.				G2/M transition of mitotic cell cycle	centriole|cytosol				central_nervous_system(1)	1						AGTACATTAGAGCCGAGGTTC	0.448		NA											18	32					0	0	0	0
C22orf42	150297	broad.mit.edu	37	22	32555017	32555017	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr22:32555017C>G	uc003amd.2	-	1	227	c.186G>C	c.(184-186)CAG>CAC	p.Q62H		NM_001010859	NP_001010859	Q6IC83	CV042_HUMAN	chromosome 22 open reading frame 42	62										ovary(1)|skin(1)	2						GGCTGAGGTACTGCATGAGTT	0.537		NA											61	174					0	0	0	0
SSTR3	6753	broad.mit.edu	37	22	37603377	37603377	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr22:37603377T>A	uc003ara.2	-	2	528	c.466A>T	c.(466-468)ACA>TCA	p.T156S	SSTR3_uc003arb.2_Missense_Mutation_p.T156S	NM_001051	NP_001042	P32745	SSR3_HUMAN	somatostatin receptor 3	156	Cytoplasmic (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|induction of apoptosis by hormones|negative regulation of cell proliferation	integral to plasma membrane|nonmotile primary cilium	somatostatin receptor activity			lung(1)	1						ACCGGAGCTGTGCGCCAGCGG	0.677		NA											30	53					0	0	0	0
APOBEC3B	9582	broad.mit.edu	37	22	39380220	39380220	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr22:39380220G>T	uc003awo.1	+	2	212	c.158G>T	c.(157-159)GGG>GTG	p.G53V	APOBEC3A_uc011aoc.1_Intron|APOBEC3B_uc003awp.1_Missense_Mutation_p.G53V|APOBEC3B_uc003awq.1_RNA|APOBEC3D_uc011aod.1_Intron|APOBEC3D_uc011aoe.1_Intron|APOBEC3D_uc011aof.1_Intron	NM_004900	NP_004891	Q9UH17	ABC3B_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic	53					negative regulation of transposition		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|RNA binding|zinc ion binding			ovary(1)	1	Melanoma(58;0.04)					TGGGACACAGGGGTCTTTCGA	0.368		NA											23	7					7.88e-14	1.49e-13	1	0
CACNA1I	8911	broad.mit.edu	37	22	40042659	40042659	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr22:40042659T>C	uc003ayc.2	+	8	1235	c.1235T>C	c.(1234-1236)ATG>ACG	p.M412T	CACNA1I_uc003ayd.2_Missense_Mutation_p.M412T|CACNA1I_uc003aye.2_Missense_Mutation_p.M327T|CACNA1I_uc003ayf.2_Missense_Mutation_p.M327T	NM_021096	NP_066919	Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type,	412	Cytoplasmic (Potential).				axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(1)|central_nervous_system(1)	2	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	CACCGGCTGATGCTGGAGCAG	0.607		NA											5	7					0	0	0	0
FAM83F	113828	broad.mit.edu	37	22	40417675	40417675	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr22:40417675C>T	uc003ayk.1	+	4	1255	c.1161C>T	c.(1159-1161)CCC>CCT	p.P387P		NM_138435	NP_612444	Q8NEG4	FA83F_HUMAN	hypothetical protein LOC113828	387										breast(1)	1						TGCTGCCCCCCGTGGAGCCCA	0.662		NA											13	48					0	0	0	0
ACO2	50	broad.mit.edu	37	22	41918884	41918884	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr22:41918884G>T	uc003bac.2	+	10	1211	c.1189G>T	c.(1189-1191)GCA>TCA	p.A397S	ACO2_uc003bad.2_Missense_Mutation_p.A422S	NM_001098	NP_001089	Q99798	ACON_HUMAN	aconitase 2, mitochondrial precursor	397					citrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleus	4 iron, 4 sulfur cluster binding|aconitate hydratase activity|citrate hydro-lyase (cis-aconitate-forming) activity|iron ion binding|isocitrate hydro-lyase (cis-aconitate-forming) activity			breast(2)|ovary(1)|lung(1)	4						GGGGCGCTCAGCAGCTGTGGC	0.572		NA											22	49					5.26e-13	9.82e-13	1	0
PRR5	55615	broad.mit.edu	37	22	45132772	45132772	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr22:45132772C>A	uc003bfb.1	+	8	1084	c.812C>A	c.(811-813)GCG>GAG	p.A271E	PRR5_uc003bew.1_Missense_Mutation_p.A262E|PRR5_uc003bex.1_Missense_Mutation_p.A176E|PRR5_uc010gzt.1_Missense_Mutation_p.A294E|PRR5_uc010gzu.1_Missense_Mutation_p.A235E|PRR5_uc003bey.1_Missense_Mutation_p.A262E|PRR5_uc003bez.1_Missense_Mutation_p.A176E|PRR5-ARHGAP8_uc003bfc.2_Intron|PRR5-ARHGAP8_uc003bfd.2_Intron|PRR5-ARHGAP8_uc011aqi.1_Intron|PRR5-ARHGAP8_uc011aqj.1_Intron|PRR5_uc003bfa.1_Missense_Mutation_p.A164E|PRR5_uc003bfe.1_RNA|PRR5-ARHGAP8_uc003bfg.1_Intron|PRR5_uc003bfh.1_Missense_Mutation_p.A170E	NM_181333	NP_851850	P85299	PRR5_HUMAN	proline rich 5 (renal) isoform 1	271					cell cycle					skin(1)	1		all_neural(38;0.00409)|Ovarian(80;0.024)|Glioma(61;0.0647)		UCEC - Uterine corpus endometrioid carcinoma (28;0.168)		GCGGAGGGCGCGGCGGCCGGC	0.711		NA											13	39					1.58e-08	2.73e-08	1	0
GTSE1	51512	broad.mit.edu	37	22	46704670	46704670	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr22:46704670C>A	uc011aqy.1	+	4	804	c.592C>A	c.(592-594)CGC>AGC	p.R198S	GTSE1_uc011aqz.1_Missense_Mutation_p.R45S	NM_016426	NP_057510	Q9NYZ3	GTSE1_HUMAN	G-2 and S-phase expressed 1	179					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G2 phase of mitotic cell cycle|microtubule-based process	cytoplasmic microtubule				ovary(1)	1		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00462)		TGCCCAGGCCCGCCTCACCCG	0.677		NA											45	87					6.48e-29	1.36e-28	1	0
CRELD2	79174	broad.mit.edu	37	22	50315316	50315316	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr22:50315316C>A	uc003bja.2	+	5	634	c.499C>A	c.(499-501)CGG>AGG	p.R167R	CRELD2_uc003biz.3_Silent_p.R167R|CRELD2_uc010haj.2_Silent_p.R167R|CRELD2_uc010hal.2_Silent_p.R167R|CRELD2_uc010hak.2_Silent_p.R167R|CRELD2_uc010ham.2_Silent_p.R167R	NM_024324	NP_077300	Q6UXH1	CREL2_HUMAN	cysteine-rich with EGF-like domains 2 isoform b	167	EGF-like 1.					endoplasmic reticulum|extracellular region	calcium ion binding				0		all_cancers(38;5.53e-07)|all_epithelial(38;3.84e-06)|all_lung(38;0.00208)|Breast(42;0.0104)|Lung NSC(38;0.0199)|Ovarian(80;0.0907)|Lung SC(80;0.236)		BRCA - Breast invasive adenocarcinoma(115;0.198)|LUAD - Lung adenocarcinoma(64;0.247)		CGGGTCCTGCCGGTGCCACAT	0.647		NA											29	102					1.75e-13	3.3e-13	1	0
FGD5	152273	broad.mit.edu	37	3	14939485	14939485	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:14939485G>A	uc003bzc.2	+	6	3059	c.2949G>A	c.(2947-2949)CGG>CGA	p.R983R	FGD5_uc011avk.1_Silent_p.R983R|FGD5_uc003bzd.2_Silent_p.R61R	NM_152536	NP_689749	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	983	DH.				actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|kidney(1)|pancreas(1)	5						TCCTGGCCCGGGAGCAGGGGT	0.577		NA											24	38					0	0	0	0
RFTN1	23180	broad.mit.edu	37	3	16475401	16475401	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:16475401G>T	uc003cay.2	-	3	571	c.289C>A	c.(289-291)CTG>ATG	p.L97M	RFTN1_uc010hes.2_Missense_Mutation_p.L61M	NM_015150	NP_055965	Q14699	RFTN1_HUMAN	raft-linking protein	97						plasma membrane				ovary(3)|central_nervous_system(1)	4						ATGTGCTCCAGGGGCGTCTTC	0.597		NA											50	103					2.56e-31	5.38e-31	1	0
ZNF385D	79750	broad.mit.edu	37	3	21465512	21465512	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:21465512G>T	uc003cce.2	-	7	1305	c.897C>A	c.(895-897)CCC>CCA	p.P299P		NM_024697	NP_078973	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	299						nucleus	nucleic acid binding|zinc ion binding			large_intestine(2)|skin(2)|ovary(1)	5						TAGGTTTCGGGGGCTTCCCAG	0.418		NA											34	40					2.55e-27	5.31e-27	1	0
ZNF385D	79750	broad.mit.edu	37	3	21606087	21606087	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:21606087G>T	uc003cce.2	-	3	663	c.255C>A	c.(253-255)TGC>TGA	p.C85*	ZNF385D_uc010hfb.1_RNA	NM_024697	NP_078973	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	85	Matrin-type 1.					nucleus	nucleic acid binding|zinc ion binding			large_intestine(2)|skin(2)|ovary(1)	5						ATCTCAACTGGCAAATGTTGC	0.343		NA											15	28					3.27e-08	5.61e-08	1	0
TGFBR2	7048	broad.mit.edu	37	3	30691784	30691784	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:30691784A>G	uc003ceo.2	+	3	668	c.286A>G	c.(286-288)ACA>GCA	p.T96A	TGFBR2_uc003cen.2_Missense_Mutation_p.T121A	NM_003242	NP_003233	P37173	TGFR2_HUMAN	transforming growth factor, beta receptor II	96	Extracellular (Potential).				activation of protein kinase activity|brain development|embryonic cranial skeleton morphogenesis|embryonic hemopoiesis|heart development|myeloid dendritic cell differentiation|palate development|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of B cell tolerance induction|positive regulation of mesenchymal cell proliferation|positive regulation of NK T cell differentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of T cell tolerance induction|positive regulation of tolerance induction to self antigen|response to cholesterol|response to drug|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|vasculogenesis	caveola|external side of plasma membrane	ATP binding|glycosaminoglycan binding|metal ion binding|protein binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type II|type I transforming growth factor beta receptor binding|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding			pancreas(9)|large_intestine(6)|stomach(4)|lung(3)|ovary(3)|central_nervous_system(1)	26						CGAGAACATAACACTAGAGAC	0.428		NA											27	34					0	0	0	0
TRANK1	9881	broad.mit.edu	37	3	36899135	36899135	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:36899135G>T	uc003cgj.2	-	3	598	c.296C>A	c.(295-297)ACT>AAT	p.T99N		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	649					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						TGTTCTGGCAGTGGCACCACA	0.597		NA											35	34					1.27e-14	2.43e-14	1	0
SCN10A	6336	broad.mit.edu	37	3	38763808	38763808	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:38763808C>A	uc003ciq.2	-	19	3448	c.3448G>T	c.(3448-3450)GAG>TAG	p.E1150*		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	1150	III.|Helical; Name=S1 of repeat III; (Potential).				sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	CAGCTGTGCTCCACGATACGG	0.547		NA											20	33					0.000132079	0.000201779	1	0
SCN11A	11280	broad.mit.edu	37	3	38946691	38946691	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:38946691G>T	uc011ays.1	-	11	1794	c.1595C>A	c.(1594-1596)ACC>AAC	p.T532N		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	532					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	ACCCTTCATGGTGATGGTGAG	0.488		NA											57	58					6.18e-18	1.23e-17	1	0
CCR8	1237	broad.mit.edu	37	3	39374449	39374449	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:39374449C>T	uc010hhr.2	+	2	765	c.627C>T	c.(625-627)ATC>ATT	p.I209I	CCR8_uc003cjm.2_Silent_p.I126I	NM_005201	NP_005192	P51685	CCR8_HUMAN	chemokine (C-C motif) receptor 8	209	Helical; Name=5; (Potential).				cell adhesion|chemotaxis|elevation of cytosolic calcium ion concentration|immune response	integral to plasma membrane	coreceptor activity			ovary(1)|lung(1)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0504)|Kidney(284;0.0635)		GCTTGTTGATCCCATTCACCA	0.398		NA											25	34					0	0	0	0
CCK	885	broad.mit.edu	37	3	42304950	42304950	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:42304950A>T	uc003clc.1	-	2	382	c.173T>A	c.(172-174)CTG>CAG	p.L58Q	CCK_uc003cld.1_Missense_Mutation_p.L58Q|CCK_uc011azk.1_Missense_Mutation_p.L58Q	NM_000729	NP_000720	P06307	CCKN_HUMAN	cholecystokinin preproprotein	58					axonogenesis|eating behavior|neuron migration		neuropeptide hormone activity			central_nervous_system(1)	1		Ovarian(412;0.0728)		KIRC - Kidney renal clear cell carcinoma(284;0.219)		CAGGGCGCCCAGGTGCGCTCG	0.672		NA											32	58					0	0	0	0
C3orf23	285343	broad.mit.edu	37	3	44441904	44441904	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:44441904G>T	uc010him.2	+	9	1188	c.943G>T	c.(943-945)GAC>TAC	p.D315Y	C3orf23_uc003cnd.3_Missense_Mutation_p.D315Y|C3orf23_uc003cne.3_Missense_Mutation_p.D171Y	NM_173826	NP_776187	Q8N3R3	CC023_HUMAN	hypothetical protein LOC285343 isoform 1	315						mitochondrion				upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(197;0.0468)|Kidney(197;0.0585)		GATTTTAGAAGACCAAATAAG	0.318		NA											11	25					1.59e-06	2.59e-06	1	0
CSPG5	10675	broad.mit.edu	37	3	47618790	47618790	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:47618790C>T	uc003crp.3	-	2	902	c.726G>A	c.(724-726)GAG>GAA	p.E242E	CSPG5_uc003crn.2_Silent_p.E104E|CSPG5_uc003cro.3_Silent_p.E242E|CSPG5_uc011bbb.1_Silent_p.E104E	NM_006574	NP_006565	O95196	CSPG5_HUMAN	chondroitin sulfate proteoglycan 5 (neuroglycan	242	Extracellular (Potential).				cell differentiation|intracellular transport|nervous system development|regulation of growth	endoplasmic reticulum membrane|Golgi-associated vesicle membrane|integral to plasma membrane|membrane fraction	growth factor activity			ovary(1)|central_nervous_system(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000266)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		GGGTCTCTCCCTCAGTATCAG	0.517		NA											9	12					0	0	0	0
USP4	7375	broad.mit.edu	37	3	49377429	49377429	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:49377429C>G	uc003cwq.2	-	1	108	c.29G>C	c.(28-30)CGA>CCA	p.R10P	USP4_uc003cwr.2_Missense_Mutation_p.R10P	NM_003363	NP_003354	Q13107	UBP4_HUMAN	ubiquitin specific protease 4 isoform a	10					negative regulation of protein ubiquitination|protein deubiquitination|protein localization at cell surface|regulation of protein stability|ubiquitin-dependent protein catabolic process	lysosome|nucleus	adenosine receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|urinary_tract(1)|lung(1)	4		Ovarian(412;0.00308)|Myeloproliferative disorder(1037;0.0255)|Hepatocellular(537;0.121)		OV - Ovarian serous cystadenocarcinoma(275;4.74e-26)|Kidney(197;2.22e-07)|KIRC - Kidney renal clear cell carcinoma(197;5.14e-06)|BRCA - Breast invasive adenocarcinoma(193;9.46e-05)		CGCATCCGGTCGCTCACGGCA	0.697		NA											6	24					0	0	0	0
CACNA1D	776	broad.mit.edu	37	3	53781378	53781378	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:53781378C>A	uc003dgv.3	+	26	3380	c.3217C>A	c.(3217-3219)CGT>AGT	p.R1073S	CACNA1D_uc003dgu.3_Missense_Mutation_p.R1093S|CACNA1D_uc003dgy.3_Missense_Mutation_p.R1073S|CACNA1D_uc003dgw.3_Missense_Mutation_p.R740S|CACNA1D_uc003dgx.1_Missense_Mutation_p.R221S	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	1073	Extracellular (Potential).|III.				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	TCCTGTGGTCCGTGAACGGAT	0.527		NA											43	42					4.16e-14	7.91e-14	1	0
ADAMTS9	56999	broad.mit.edu	37	3	64608244	64608244	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:64608244C>T	uc003dmg.2	-	17	2440	c.2408G>A	c.(2407-2409)GGT>GAT	p.G803D	ADAMTS9_uc011bfo.1_Missense_Mutation_p.G775D|ADAMTS9_uc003dmh.1_Missense_Mutation_p.G632D|ADAMTS9_uc003dmk.1_Missense_Mutation_p.G803D	NM_182920	NP_891550	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1	803	Spacer.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|urinary_tract(1)|skin(1)	4		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		CAAGAATTCACCTTTACTGCT	0.388		NA											17	20					0	0	0	0
GPR27	2850	broad.mit.edu	37	3	71804129	71804129	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:71804129T>A	uc011bge.1	+	1	929	c.929T>A	c.(928-930)GTG>GAG	p.V310E	EIF4E3_uc003dox.2_5'Flank|EIF4E3_uc011bgd.1_5'Flank|EIF4E3_uc010hoc.2_5'Flank	NM_018971	NP_061844	Q9NS67	GPR27_HUMAN	G protein-coupled receptor 27	310	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1		Prostate(10;0.00899)		BRCA - Breast invasive adenocarcinoma(55;1.78e-05)|Epithelial(33;5.75e-05)|Lung(16;0.0012)|LUSC - Lung squamous cell carcinoma(21;0.00156)		CGGGTCCTGGTGCGGCCCGGC	0.667		NA											10	15					0	0	0	0
GXYLT2	727936	broad.mit.edu	37	3	73004273	73004273	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:73004273C>A	uc003dpg.2	+	4	625	c.625C>A	c.(625-627)CTT>ATT	p.L209I		NM_001080393	NP_001073862	A0PJZ3	GXLT2_HUMAN	glycosyltransferase 8 domain containing 4	209	Lumenal (Potential).				O-glycan processing	integral to membrane	UDP-xylosyltransferase activity				0						TGTGGACTCACTTCTCTACGT	0.468		NA											13	15					5.51e-06	8.83e-06	1	0
PDZRN3	23024	broad.mit.edu	37	3	73433878	73433878	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:73433878C>A	uc003dpl.1	-	10	1935	c.1839G>T	c.(1837-1839)TTG>TTT	p.L613F	PDZRN3_uc011bgh.1_Missense_Mutation_p.L270F|PDZRN3_uc010hoe.1_Missense_Mutation_p.L311F|PDZRN3_uc011bgf.1_Missense_Mutation_p.L330F|PDZRN3_uc011bgg.1_Missense_Mutation_p.L333F	NM_015009	NP_055824	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	613							ubiquitin-protein ligase activity|zinc ion binding			pancreas(2)|ovary(2)|skin(2)|large_intestine(1)	7		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		CGCCGCTGCCCAAGGTGTCCT	0.647		NA											25	36					3.01e-09	5.26e-09	1	0
POU1F1	5449	broad.mit.edu	37	3	87313582	87313582	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:87313582C>A	uc003dqq.1	-	3	420	c.295G>T	c.(295-297)GCA>TCA	p.A99S	POU1F1_uc010hoj.1_Missense_Mutation_p.A125S	NM_000306	NP_000297	P28069	PIT1_HUMAN	pituitary specific transcription factor 1	99					negative regulation of cell proliferation|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|skin(1)	2	all_cancers(8;0.104)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00229)|Lung(72;0.00677)		GGGTCCTCTGCCAGAAGAGGC	0.438		NA											39	36					6.24e-21	1.27e-20	1	0
EPHA3	2042	broad.mit.edu	37	3	89391052	89391052	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:89391052G>T	uc003dqy.2	+	5	1343	c.1118G>T	c.(1117-1119)TGT>TTT	p.C373F	EPHA3_uc003dqx.1_Missense_Mutation_p.C373F|EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	373	Extracellular (Potential).|Fibronectin type-III 1.					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		ATAAAACAGTGTGAGCCATGC	0.493		NA								TSP Lung(6;0.00050)			14	28					1.36e-06	2.23e-06	1	0
EPHA6	285220	broad.mit.edu	37	3	97454962	97454962	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:97454962T>C	uc010how.1	+	16	3171	c.3128T>C	c.(3127-3129)GTA>GCA	p.V1043A	EPHA6_uc003drt.2_Missense_Mutation_p.V435A|EPHA6_uc010hox.1_RNA	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	948	Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16						GACATCCTTGTGTAAGAGGCA	0.383		NA											44	35					0	0	0	0
OR5H14	403273	broad.mit.edu	37	3	97868383	97868383	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:97868383G>A	uc003dsg.1	+	1	154	c.154G>A	c.(154-156)GAC>AAC	p.D52N		NM_001005514	NP_001005514	A6NHG9	O5H14_HUMAN	olfactory receptor, family 5, subfamily H,	52	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						CATCTGGAAAGACCCTCATCT	0.413		NA											89	425					0	0	0	0
COL8A1	1295	broad.mit.edu	37	3	99513943	99513943	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:99513943C>A	uc003dtg.1	+	5	1443	c.1198C>A	c.(1198-1200)CCT>ACT	p.P400T	COL8A1_uc003dth.1_Missense_Mutation_p.P400T|COL8A1_uc003dti.1_Missense_Mutation_p.P401T	NM_001850	NP_001841	P27658	CO8A1_HUMAN	alpha 1 type VIII collagen precursor	400	Triple-helical region (COL1).				angiogenesis|cell adhesion	basement membrane|collagen type VIII					0						AATCCCAGGTCCTATGGGCCC	0.612		NA											8	62					0.00307968	0.00445776	1	0
MYH15	22989	broad.mit.edu	37	3	108211406	108211406	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:108211406G>A	uc003dxa.1	-	10	929	c.872C>T	c.(871-873)GCT>GTT	p.A291V		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	291	Myosin head-like.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7						CCTCTCTCCAGCCTGCTGGAA	0.368		NA											14	44					0	0	0	0
TRAT1	50852	broad.mit.edu	37	3	108549617	108549617	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:108549617G>T	uc003dxi.1	+	2	252	c.108G>T	c.(106-108)AAG>AAT	p.K36N	TRAT1_uc010hpx.1_Intron	NM_016388	NP_057472	Q6PIZ9	TRAT1_HUMAN	T-cell receptor interacting molecule	36	Cytoplasmic (Potential).				cellular defense response|negative regulation of receptor recycling|negative regulation of transport|positive regulation of calcium-mediated signaling|positive regulation of T cell receptor signaling pathway|T cell receptor signaling pathway	integral to plasma membrane|T cell receptor complex	phosphatidylinositol-4,5-bisphosphate 3-kinase activity|transmembrane receptor protein tyrosine kinase adaptor activity			skin(1)	1						ATGTGGAAAAGCAACGACAAG	0.418		NA											36	178					6.03e-25	1.26e-24	1	0
TRAT1	50852	broad.mit.edu	37	3	108568018	108568018	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:108568018A>G	uc003dxi.1	+	5	364	c.220A>G	c.(220-222)ATG>GTG	p.M74V	TRAT1_uc010hpx.1_Missense_Mutation_p.M37V	NM_016388	NP_057472	Q6PIZ9	TRAT1_HUMAN	T-cell receptor interacting molecule	74	Cytoplasmic (Potential).				cellular defense response|negative regulation of receptor recycling|negative regulation of transport|positive regulation of calcium-mediated signaling|positive regulation of T cell receptor signaling pathway|T cell receptor signaling pathway	integral to plasma membrane|T cell receptor complex	phosphatidylinositol-4,5-bisphosphate 3-kinase activity|transmembrane receptor protein tyrosine kinase adaptor activity			skin(1)	1						CCAAGAACCAATGGATGAAAA	0.338		NA											15	71					0	0	0	0
ADPRH	141	broad.mit.edu	37	3	119301305	119301305	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:119301305C>A	uc003ecs.2	+	3	587	c.289C>A	c.(289-291)CGG>AGG	p.R97R	ADPRH_uc010hqv.2_Silent_p.R97R|ADPRH_uc011bjb.1_Intron|ADPRH_uc003ect.2_Silent_p.R97R	NM_001125	NP_001116	P54922	ADPRH_HUMAN	ADP-ribosylarginine hydrolase	97					protein de-ADP-ribosylation		ADP-ribosylarginine hydrolase activity|magnesium ion binding			ovary(1)	1		Lung NSC(201;0.0977)		GBM - Glioblastoma multiforme(114;0.23)		CATGGATGGGCGGGCACCAGG	0.473		NA											14	84					9.77e-05	0.000149631	1	0
GTF2E1	2960	broad.mit.edu	37	3	120469827	120469827	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:120469827A>T	uc003edz.3	+	2	542	c.428A>T	c.(427-429)CAG>CTG	p.Q143L	GTF2E1_uc003edy.2_Missense_Mutation_p.Q143L	NM_005513	NP_005504	P29083	T2EA_HUMAN	general transcription factor IIE, polypeptide 1,	143	C4-type (Potential).				interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	nucleoplasm	protein binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.159)		GAAGCTAATCAGCTCTTTGAT	0.353		NA											18	64					0	0	0	0
STXBP5L	9515	broad.mit.edu	37	3	121001149	121001149	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:121001149C>A	uc003eec.3	+	20	2287	c.2147C>A	c.(2146-2148)CCT>CAT	p.P716H	STXBP5L_uc011bji.1_Intron	NM_014980	NP_055795	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	716					exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				ovary(7)|skin(2)	9				GBM - Glioblastoma multiforme(114;0.0694)		AACTTTTATCCTGATTTAACG	0.383		NA											15	54					1.36e-06	2.23e-06	1	0
CD86	942	broad.mit.edu	37	3	121838297	121838297	+	Silent	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:121838297T>C	uc003eet.2	+	7	1022	c.906T>C	c.(904-906)CAT>CAC	p.H302H	CD86_uc011bjo.1_Silent_p.H220H|CD86_uc011bjp.1_Silent_p.H190H|CD86_uc003eeu.2_Silent_p.H296H	NM_175862	NP_787058	P42081	CD86_HUMAN	CD86 antigen isoform 1	302	Cytoplasmic (Potential).				interspecies interaction between organisms|positive regulation of cell proliferation|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-4 biosynthetic process|positive regulation of lymphotoxin A biosynthetic process|positive regulation of T-helper 2 cell differentiation|positive regulation of transcription, DNA-dependent|T cell costimulation		coreceptor activity|protein binding			pancreas(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.156)	Abatacept(DB01281)	AAAAAATCCATATACCTGAAA	0.338		NA											17	57					0	0	0	0
SEMA5B	54437	broad.mit.edu	37	3	122642512	122642512	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:122642512G>T	uc003efz.1	-	10	1528	c.1224C>A	c.(1222-1224)AAC>AAA	p.N408K	SEMA5B_uc011bju.1_Missense_Mutation_p.N350K|SEMA5B_uc003ega.1_RNA|SEMA5B_uc003egb.1_Missense_Mutation_p.N408K|SEMA5B_uc010hro.1_Missense_Mutation_p.N350K|SEMA5B_uc010hrp.1_RNA	NM_001031702	NP_001026872	Q9P283	SEM5B_HUMAN	semaphorin 5B isoform 1	408	Extracellular (Potential).|Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			ovary(2)|breast(2)|pancreas(2)|central_nervous_system(1)	7				GBM - Glioblastoma multiforme(114;0.0367)		CAGCCCTGGGGTTCTCCTGGT	0.557		NA											31	135					1.89e-17	3.75e-17	1	0
MYLK	4638	broad.mit.edu	37	3	123427705	123427705	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:123427705C>A	uc003ego.2	-	15	2262	c.1980G>T	c.(1978-1980)GGG>GGT	p.G660G	MYLK_uc011bjw.1_Silent_p.G660G|MYLK_uc003egp.2_Silent_p.G591G|MYLK_uc003egq.2_Silent_p.G660G|MYLK_uc003egr.2_Silent_p.G591G|MYLK_uc003egs.2_Silent_p.G484G	NM_053025	NP_444253	Q15746	MYLK_HUMAN	myosin light chain kinase isoform 1	660	Ig-like C2-type 5.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			ovary(6)|skin(2)|stomach(1)	9		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		GGATCTCATTCCCATTGTGCA	0.562		NA											22	127					9.96e-16	1.94e-15	1	0
CCDC14	64770	broad.mit.edu	37	3	123633847	123633847	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:123633847G>T	uc011bjx.1	-	13	2732	c.2641C>A	c.(2641-2643)CAT>AAT	p.H881N	CCDC14_uc003egv.3_Missense_Mutation_p.H522N|CCDC14_uc003egx.3_Missense_Mutation_p.H681N|CCDC14_uc010hrt.2_Missense_Mutation_p.H840N|CCDC14_uc003egy.3_Missense_Mutation_p.H681N|CCDC14_uc003egz.2_3'UTR	NM_022757	NP_073594	Q49A88	CCD14_HUMAN	coiled-coil domain containing 14	881						centrosome					0		Lung NSC(201;0.0371)|Prostate(884;0.0405)|Myeloproliferative disorder(1037;0.205)		Lung(219;0.00942)|GBM - Glioblastoma multiforme(114;0.159)		GATGGGCCATGACATGCAGTT	0.458		NA											18	89					3.41e-10	6.11e-10	1	0
KALRN	8997	broad.mit.edu	37	3	124377324	124377324	+	Missense_Mutation	SNP	G	G	T	rs144160219	byFrequency	TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:124377324G>T	uc003ehg.2	+	42	6207	c.6080G>T	c.(6079-6081)CGC>CTC	p.R2027L	KALRN_uc003ehi.2_Missense_Mutation_p.R368L|KALRN_uc003ehk.2_Missense_Mutation_p.R330L|KALRN_uc011bjz.1_Missense_Mutation_p.R119L	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	2026	DH 2.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						AATAAGCCGCGCTCAGAGTAC	0.507		NA											24	99					1.18e-12	2.18e-12	1	0
ALDH1L1	10840	broad.mit.edu	37	3	125879696	125879696	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:125879696C>A	uc003eim.1	-	2	317	c.127G>T	c.(127-129)GGT>TGT	p.G43C	ALDH1L1_uc010hse.1_RNA|ALDH1L1_uc011bki.1_Missense_Mutation_p.G43C|ALDH1L1_uc010hsf.1_Missense_Mutation_p.W7C|ALDH1L1_uc003eip.1_5'Flank|ALDH1L1_uc011bkj.1_5'UTR	NM_012190	NP_036322	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	43	GART.				10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	GCTCACTCACCCAGGGGGTCG	0.602		NA											28	162					9.39e-14	1.78e-13	1	0
UROC1	131669	broad.mit.edu	37	3	126218903	126218903	+	Missense_Mutation	SNP	C	C	A	rs142723755	byFrequency	TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:126218903C>A	uc003eiz.1	-	12	1272	c.1240G>T	c.(1240-1242)GCA>TCA	p.A414S	UROC1_uc010hsi.1_Missense_Mutation_p.A474S	NM_144639	NP_653240	Q96N76	HUTU_HUMAN	urocanase domain containing 1 isoform 1	414					histidine catabolic process	cytosol	urocanate hydratase activity			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.17)		ctcctACCTGCTCTCTGGGCC	0.532		NA											15	64					2.23e-06	3.63e-06	1	0
TXNRD3IT1	645840	broad.mit.edu	37	3	126291216	126291216	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:126291216C>A	uc003ejc.2	-	3	650	c.171G>T	c.(169-171)GGG>GGT	p.G57G		NM_001039783	NP_001034872	Q6F5E7	TR3N_HUMAN	thioredoxin reductase 3 intronic transcript 1	57											0						GACTGGGAAACCCCTGTCCAA	0.393		NA											22	90					0.00278032	0.00404879	1	0
EEFSEC	60678	broad.mit.edu	37	3	128060074	128060074	+	Splice_Site	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:128060074A>T	uc003eki.2	+	5	825	c.787_splice	c.e5-2	p.V263_splice	EEFSEC_uc003ekj.2_Splice_Site_p.V208_splice	NM_021937	NP_068756	P57772	SELB_HUMAN	eukaryotic elongation factor,							cytoplasm|nucleus	GTP binding|GTPase activity|translation elongation factor activity			ovary(1)	1						ACTCCCCATCAGGTGGTGAAG	0.562		NA											26	100					0	0	0	0
RAB7A	7879	broad.mit.edu	37	3	128516832	128516832	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:128516832A>C	uc003eks.1	+	3	332	c.100A>C	c.(100-102)AGC>CGC	p.S34R	RAB7A_uc010hsv.1_Missense_Mutation_p.S34R|RAB7A_uc003ekt.2_Missense_Mutation_p.S10R	NM_004637	NP_004628	P51149	RAB7A_HUMAN	RAB7, member RAS oncogene family	34					endocytosis|endosome to lysosome transport|epidermal growth factor catabolic process|protein transport|small GTPase mediated signal transduction	Golgi apparatus|late endosome|lysosome|melanosome|phagocytic vesicle	GDP binding|GTP binding|GTPase activity|protein binding				0				GBM - Glioblastoma multiforme(114;0.231)		TAAGAAATTCAGCAATCAGTA	0.433		NA											30	109					0	0	0	0
GP9	2815	broad.mit.edu	37	3	128780893	128780893	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:128780893C>G	uc003elm.2	+	3	498	c.311C>G	c.(310-312)ACG>AGG	p.T104R		NM_000174	NP_000165	P14770	GPIX_HUMAN	glycoprotein IX (platelet) precursor	104	LRRCT.|Extracellular (Potential).				blood coagulation, intrinsic pathway|cell adhesion|platelet activation	integral to plasma membrane	protein binding				0					Quinine(DB00468)	GAGGACCGCACGCCCGAGGCC	0.692		NA											15	64					0	0	0	0
PIK3R4	30849	broad.mit.edu	37	3	130442379	130442379	+	Silent	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:130442379C>G	uc003enj.2	-	7	2441	c.1860G>C	c.(1858-1860)CTG>CTC	p.L620L		NM_014602	NP_055417	Q99570	PI3R4_HUMAN	phosphoinositide-3-kinase, regulatory subunit 4	620					fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|breast(2)|skin(2)|stomach(1)|central_nervous_system(1)|kidney(1)	12						GACCTTGTTGCAGCAGAGGCT	0.408		NA											29	36					0	0	0	0
ATP2C1	27032	broad.mit.edu	37	3	130683850	130683850	+	Silent	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:130683850T>A	uc003enl.2	+	14	1305	c.1083T>A	c.(1081-1083)ACT>ACA	p.T361T	ATP2C1_uc011blg.1_Silent_p.T395T|ATP2C1_uc011blh.1_Silent_p.T356T|ATP2C1_uc011bli.1_Silent_p.T395T|ATP2C1_uc003enk.2_Silent_p.T345T|ATP2C1_uc003enm.2_Silent_p.T361T|ATP2C1_uc003enn.2_Silent_p.T345T|ATP2C1_uc003eno.2_Silent_p.T361T|ATP2C1_uc003enp.2_Silent_p.T361T|ATP2C1_uc003enq.2_Silent_p.T361T|ATP2C1_uc003enr.2_Silent_p.T361T|ATP2C1_uc003ens.2_Silent_p.T361T|ATP2C1_uc003ent.2_Silent_p.T361T|ATP2C1_uc003enu.2_Silent_p.T39T	NM_014382	NP_055197	P98194	AT2C1_HUMAN	calcium-transporting ATPase 2C1 isoform 1a	361	Cytoplasmic (By similarity).				actin cytoskeleton reorganization|ATP biosynthetic process|calcium-dependent cell-cell adhesion|cellular calcium ion homeostasis|cellular manganese ion homeostasis|epidermis development|Golgi calcium ion homeostasis|Golgi calcium ion transport|positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi apparatus|Golgi membrane|integral to membrane|trans-Golgi network	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|manganese ion binding|manganese-transporting ATPase activity|metal ion binding|signal transducer activity			skin(1)	1					Arsenic trioxide(DB01169)|Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Miconazole(DB01110)|Sevoflurane(DB01236)	ATGAAATGACTGTTACTCACA	0.333		NA							Hailey-Hailey_disease				55	43					0	0	0	0
CPNE4	131034	broad.mit.edu	37	3	131624228	131624228	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:131624228G>T	uc003eok.2	-	2	495	c.60C>A	c.(58-60)AGC>AGA	p.S20R	CPNE4_uc011blq.1_Missense_Mutation_p.S38R|CPNE4_uc003eol.2_Missense_Mutation_p.S38R|CPNE4_uc003eom.2_Missense_Mutation_p.S20R	NM_130808	NP_570720	Q96A23	CPNE4_HUMAN	copine IV	20										upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						TCAGGCAGGGGCTGTTAAAGA	0.458		NA											18	57					1.68e-08	2.89e-08	1	0
SLCO2A1	6578	broad.mit.edu	37	3	133672524	133672524	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:133672524T>A	uc003eqa.3	-	5	981	c.707A>T	c.(706-708)TAT>TTT	p.Y236F	SLCO2A1_uc003eqb.3_Missense_Mutation_p.Y160F|SLCO2A1_uc011blv.1_Intron|SLCO2A1_uc010htw.1_Missense_Mutation_p.Y68F	NM_005630	NP_005621	Q92959	SO2A1_HUMAN	solute carrier organic anion transporter family,	236	Helical; Name=5; (Potential).				sodium-independent organic anion transport	integral to plasma membrane|membrane fraction	prostaglandin transmembrane transporter activity|protein binding			central_nervous_system(1)	1						GACCCTGCCATAGTCCACAAA	0.522		NA											64	58					0	0	0	0
ESYT3	83850	broad.mit.edu	37	3	138174129	138174129	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:138174129C>A	uc003esk.2	+	3	689	c.463C>A	c.(463-465)CTG>ATG	p.L155M	ESYT3_uc010hug.2_RNA	NM_031913	NP_114119	A0FGR9	ESYT3_HUMAN	family with sequence similarity 62 (C2 domain	155						integral to membrane|plasma membrane					0						GAGCATCCACCTGAGGACCTT	0.522		NA											19	105					1.16e-05	1.85e-05	1	0
ZBTB38	253461	broad.mit.edu	37	3	141163889	141163889	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:141163889A>T	uc003etw.2	+	8	3641	c.2659A>T	c.(2659-2661)AGC>TGC	p.S887C	ZBTB38_uc010hun.2_Missense_Mutation_p.S884C|ZBTB38_uc010huo.2_Missense_Mutation_p.S887C|ZBTB38_uc003ety.2_Missense_Mutation_p.S887C|ZBTB38_uc010hup.2_Missense_Mutation_p.S888C	NM_001080412	NP_001073881	Q8NAP3	ZBT38_HUMAN	zinc finger and BTB domain containing 38	887					positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						CAGTGGAGACAGCCCACTCGG	0.507		NA											19	65					0	0	0	0
XRN1	54464	broad.mit.edu	37	3	142030457	142030457	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:142030457G>C	uc003eus.2	-	42	5084	c.5017C>G	c.(5017-5019)CAA>GAA	p.Q1673E	XRN1_uc010huu.2_Missense_Mutation_p.Q1127E|XRN1_uc003eut.2_Missense_Mutation_p.Q1660E|XRN1_uc003euu.2_Missense_Mutation_p.Q1661E	NM_019001	NP_061874	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1 isoform a	1673					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			ovary(3)	3						CTATGGCCTTGAGAGGCAGTT	0.403		NA											30	170					0	0	0	0
SLC9A9	285195	broad.mit.edu	37	3	143292939	143292939	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:143292939C>A	uc003evn.2	-	8	1173	c.991G>T	c.(991-993)GGC>TGC	p.G331C		NM_173653	NP_775924	Q8IVB4	SL9A9_HUMAN	solute carrier family 9 (sodium/hydrogen	331	Helical; (Potential).				regulation of pH	integral to membrane|late endosome membrane|recycling endosome	sodium:hydrogen antiporter activity			ovary(2)|skin(1)	3						CCTGTTAGGCCGGCAGCCTCG	0.537		NA											9	66					0.000274275	0.000411185	1	0
PLSCR4	57088	broad.mit.edu	37	3	145938675	145938675	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:145938675T>G	uc010huy.2	-	3	374	c.45A>C	c.(43-45)GAA>GAC	p.E15D	PLSCR4_uc010huz.2_Missense_Mutation_p.E15D|PLSCR4_uc003evt.3_Missense_Mutation_p.E15D|PLSCR4_uc010hva.2_Missense_Mutation_p.E15D|PLSCR4_uc003evu.3_5'UTR	NM_001128305	NP_001121777	Q9NRQ2	PLS4_HUMAN	phospholipid scramblase 4 isoform a	15	Cytoplasmic (By similarity).				blood coagulation|phospholipid scrambling	integral to membrane	calcium ion binding|phospholipid scramblase activity|SH3 domain binding				0						GATTTTCCATTTCACCTGCAG	0.393		NA											11	33					0	0	0	0
CPA3	1359	broad.mit.edu	37	3	148596303	148596303	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:148596303C>A	uc003ewm.2	+	4	397	c.345C>A	c.(343-345)AGC>AGA	p.S115R		NM_001870	NP_001861	P15088	CBPA3_HUMAN	carboxypeptidase A3 precursor	115					proteolysis	stored secretory granule|transport vesicle	metallocarboxypeptidase activity|zinc ion binding			breast(1)|skin(1)	2			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			GCAGGCACAGCTACGCAAAAT	0.313		NA											67	39					3.05e-18	6.11e-18	1	0
VEPH1	79674	broad.mit.edu	37	3	157146130	157146130	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:157146130G>C	uc003fbj.1	-	5	994	c.677C>G	c.(676-678)GCA>GGA	p.A226G	VEPH1_uc003fbk.1_Missense_Mutation_p.A226G|VEPH1_uc010hvu.1_Missense_Mutation_p.A226G	NM_024621	NP_078897	Q14D04	MELT_HUMAN	ventricular zone expressed PH domain homolog 1	226						plasma membrane				breast(3)|ovary(1)|lung(1)	5			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			TTTTTTCTTTGCTGCTACATG	0.438		NA											14	89					0	0	0	0
SCHIP1	29970	broad.mit.edu	37	3	159583964	159583964	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:159583964G>A	uc003fcs.1	+	3	838	c.772G>A	c.(772-774)GAG>AAG	p.E258K	SCHIP1_uc003fcq.1_Missense_Mutation_p.E334K|SCHIP1_uc003fcr.1_Missense_Mutation_p.E247K|SCHIP1_uc003fct.1_Missense_Mutation_p.E245K|SCHIP1_uc010hvz.1_Missense_Mutation_p.E218K|SCHIP1_uc003fcu.1_Missense_Mutation_p.E15K|SCHIP1_uc003fcv.1_Missense_Mutation_p.E31K	NM_014575	NP_055390	Q9P0W5	SCHI1_HUMAN	schwannomin interacting protein 1	258						cytoplasm	identical protein binding|protein binding			ovary(1)|central_nervous_system(1)	2			LUSC - Lung squamous cell carcinoma(72;0.00523)|Lung(72;0.00534)			ACAGAAAAATGAGAGAGAGTC	0.403		NA											27	141					0	0	0	0
SI	6476	broad.mit.edu	37	3	164741509	164741509	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:164741509T>A	uc003fei.2	-	26	3010	c.2948A>T	c.(2947-2949)TAT>TTT	p.Y983F		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	983	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	GTTGACTGAATAAGAGTTATC	0.403		NA								HNSCC(35;0.089)			10	47					0	0	0	0
MECOM	2122	broad.mit.edu	37	3	168806817	168806817	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:168806817G>T	uc003ffi.3	-	15	3261	c.2992C>A	c.(2992-2994)CAG>AAG	p.Q998K	MECOM_uc010hwk.1_Missense_Mutation_p.Q1012K|MECOM_uc003ffj.3_Missense_Mutation_p.Q1063K|MECOM_uc011bpi.1_Missense_Mutation_p.Q990K|MECOM_uc003ffn.3_Missense_Mutation_p.Q998K|MECOM_uc003ffk.2_Missense_Mutation_p.Q989K|MECOM_uc003ffl.2_Missense_Mutation_p.Q1149K|MECOM_uc011bpj.1_Missense_Mutation_p.Q1186K|MECOM_uc011bpk.1_Missense_Mutation_p.Q988K	NM_005241	NP_005232	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform b	998					apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14						TGTAACGGCTGCTTAAGTTCC	0.393		NA											21	82					4.4e-07	7.32e-07	1	0
TNIK	23043	broad.mit.edu	37	3	170781743	170781743	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:170781743G>T	uc003fhh.2	-	33	4355	c.4010C>A	c.(4009-4011)GCA>GAA	p.A1337E	TNIK_uc003fhi.2_Missense_Mutation_p.A1282E|TNIK_uc003fhj.2_Missense_Mutation_p.A1308E|TNIK_uc003fhk.2_Missense_Mutation_p.A1329E|TNIK_uc003fhl.2_Missense_Mutation_p.A1253E|TNIK_uc003fhm.2_Missense_Mutation_p.A1274E|TNIK_uc003fhn.2_Missense_Mutation_p.A1300E|TNIK_uc003fho.2_Missense_Mutation_p.A1245E|TNIK_uc003fhg.2_Missense_Mutation_p.A515E	NM_015028	NP_055843	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase isoform 1	1337					actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(4)|large_intestine(1)	5	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			TCGCACGGATGCAAAAAATAC	0.403		NA											52	40					6.82e-30	1.43e-29	1	0
TNIK	23043	broad.mit.edu	37	3	170805171	170805171	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:170805171C>T	uc003fhh.2	-	24	3191	c.2846G>A	c.(2845-2847)CGC>CAC	p.R949H	TNIK_uc003fhi.2_Missense_Mutation_p.R894H|TNIK_uc003fhj.2_Missense_Mutation_p.R920H|TNIK_uc003fhk.2_Missense_Mutation_p.R941H|TNIK_uc003fhl.2_Missense_Mutation_p.R865H|TNIK_uc003fhm.2_Missense_Mutation_p.R886H|TNIK_uc003fhn.2_Missense_Mutation_p.R912H|TNIK_uc003fho.2_Missense_Mutation_p.R857H|TNIK_uc003fhg.2_Missense_Mutation_p.R127H	NM_015028	NP_055843	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase isoform 1	949	Mediates interaction with NEDD4.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(4)|large_intestine(1)	5	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			GGTTGAGACGCGCCCCAGTCC	0.582		NA											26	146					0	0	0	0
FNDC3B	64778	broad.mit.edu	37	3	172059019	172059019	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:172059019C>T	uc003fhy.2	+	17	2141	c.1969C>T	c.(1969-1971)CAG>TAG	p.Q657*	FNDC3B_uc003fhz.3_Nonsense_Mutation_p.Q657*	NM_022763	NP_073600	Q53EP0	FND3B_HUMAN	fibronectin type III domain containing 3B	657	Fibronectin type-III 4.					endoplasmic reticulum|integral to membrane				ovary(2)|breast(1)	3	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)		CGGACACAGCCAGGTTGGTTT	0.443		NA											160	139					0	0	0	0
NAALADL2	254827	broad.mit.edu	37	3	175184791	175184791	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:175184791A>G	uc003fit.2	+	8	1439	c.1352A>G	c.(1351-1353)CAT>CGT	p.H451R	NAALADL2_uc003fiu.1_Missense_Mutation_p.H444R|NAALADL2_uc010hwy.1_Missense_Mutation_p.H225R|NAALADL2_uc010hwz.1_Missense_Mutation_p.H45R	NM_207015	NP_996898	Q58DX5	NADL2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	451	Extracellular (Potential).				proteolysis	integral to membrane	peptidase activity			pancreas(1)	1	Ovarian(172;0.0102)	all_cancers(1;0.0272)|all_epithelial(1;0.0553)	OV - Ovarian serous cystadenocarcinoma(80;9.26e-28)	Colorectal(1;1.66e-10)|COAD - Colon adenocarcinoma(1;2.1e-07)|STAD - Stomach adenocarcinoma(1;0.00261)|READ - Rectum adenocarcinoma(3;0.0284)		GTTGGCAGCCATCATCACACT	0.363		NA											66	310					0	0	0	0
USP13	8975	broad.mit.edu	37	3	179418886	179418886	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:179418886C>A	uc003fkh.2	+	4	527	c.446C>A	c.(445-447)GCA>GAA	p.A149E	USP13_uc003fkf.2_Missense_Mutation_p.A149E	NM_003940	NP_003931	Q92995	UBP13_HUMAN	ubiquitin thiolesterase 13	149					ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|omega peptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			ovary(1)	1	all_cancers(143;7.79e-15)|Ovarian(172;0.0338)|Breast(254;0.148)		OV - Ovarian serous cystadenocarcinoma(80;1e-25)|GBM - Glioblastoma multiforme(14;0.0169)			TATGAAATAGCACTACCAAAT	0.443		NA											41	56					4.14e-20	8.4e-20	1	0
LAMP3	27074	broad.mit.edu	37	3	182841971	182841971	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:182841971C>A	uc003flh.3	-	6	1373	c.1149G>T	c.(1147-1149)GTG>GTT	p.V383V		NM_014398	NP_055213	Q9UQV4	LAMP3_HUMAN	lysosomal-associated membrane protein 3	383	Helical; (Potential).				cell proliferation	integral to membrane|lysosomal membrane				ovary(2)|central_nervous_system(1)	3	all_cancers(143;9.14e-14)|Ovarian(172;0.0355)		all cancers(12;2.91e-44)|Epithelial(37;5.52e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;4.16e-21)			TCACAGGAAGCACAATTGTGT	0.423		NA											25	100					1.66e-10	2.98e-10	1	0
MCF2L2	23101	broad.mit.edu	37	3	182924003	182924003	+	Splice_Site	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:182924003C>A	uc003fli.1	-	24	2803	c.2713_splice	c.e24-1	p.L905_splice		NM_015078	NP_055893	Q86YR7	MF2L2_HUMAN	Rho family guanine-nucleotide exchange factor						regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)|large_intestine(2)|breast(1)	5	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			GTGTCATCAGCTATTATAAAG	0.408		NA											25	133					4.27e-12	7.84e-12	1	0
YEATS2	55689	broad.mit.edu	37	3	183508669	183508669	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:183508669G>A	uc003fly.2	+	21	3193	c.2998G>A	c.(2998-3000)GCC>ACC	p.A1000T	YEATS2_uc003flz.2_Missense_Mutation_p.A79T	NM_018023	NP_060493	Q9ULM3	YETS2_HUMAN	YEATS domain containing 2	1000					histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			ovary(3)|large_intestine(1)	4	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			TGTGAGCCAGGCCACCGTGGG	0.597		NA											32	140					0	0	0	0
HTR3E	285242	broad.mit.edu	37	3	183823166	183823166	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:183823166C>A	uc010hxq.2	+	6	1137	c.671C>A	c.(670-672)ACC>AAC	p.T224N	HTR3E_uc003fml.3_Missense_Mutation_p.T209N|HTR3E_uc003fmm.2_Missense_Mutation_p.T239N|HTR3E_uc010hxr.2_Missense_Mutation_p.T250N|HTR3E_uc003fmn.2_Missense_Mutation_p.T224N	NM_182589	NP_872395	A5X5Y0	5HT3E_HUMAN	5-hydroxytryptamine receptor 3 subunit E	224	Extracellular (Potential).					integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(143;1.46e-10)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			AGCAAGGCCACCGCAAAGTTG	0.527		NA											17	70					1.15e-07	1.93e-07	1	0
IL1RAP	3556	broad.mit.edu	37	3	190326880	190326880	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:190326880G>T	uc003fsm.1	+	5	653	c.447G>T	c.(445-447)CTG>CTT	p.L149L	IL1RAP_uc003fsk.2_Silent_p.L149L|IL1RAP_uc003fsl.2_Silent_p.L149L|IL1RAP_uc010hzf.2_Silent_p.L8L|IL1RAP_uc010hzg.1_Silent_p.L149L|IL1RAP_uc003fsn.1_RNA|IL1RAP_uc003fso.1_Silent_p.L149L|IL1RAP_uc003fsp.1_RNA|IL1RAP_uc003fsq.2_Silent_p.L149L	NM_002182	NP_002173	Q9NPH3	IL1AP_HUMAN	interleukin 1 receptor accessory protein isoform	149	Extracellular (Potential).|Ig-like C2-type 2.				inflammatory response|innate immune response|protein complex assembly	extracellular region|integral to plasma membrane				ovary(1)	1	all_cancers(143;3.61e-10)|Ovarian(172;0.0733)|Breast(254;0.21)		Lung(62;1.95e-06)|LUSC - Lung squamous cell carcinoma(58;2.05e-06)	GBM - Glioblastoma multiforme(93;0.00851)		TGCATAAACTGTATATAGAAT	0.388		NA											26	115					1.43e-11	2.61e-11	1	0
PYDC2	152138	broad.mit.edu	37	3	191179206	191179206	+	Silent	SNP	T	T	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:191179206T>G	uc011bso.1	+	1	255	c.255T>G	c.(253-255)TCT>TCG	p.S85S		NM_001083308	NP_001076777	Q56P42	PYDC2_HUMAN	pyrin domain containing 2	85	DAPIN.					cytoplasm|nucleus					0						CGCATCTGTCTGGGAGAGCTG	0.517		NA											30	180					0	0	0	0
ACAP2	23527	broad.mit.edu	37	3	195012437	195012437	+	Silent	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:195012437T>A	uc003fun.3	-	20	2302	c.2061A>T	c.(2059-2061)ACA>ACT	p.T687T		NM_012287	NP_036419	Q15057	ACAP2_HUMAN	centaurin, beta 2	687	ANK 2.				regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			large_intestine(1)|ovary(1)	2						GCAGTTACCCTGTGTGCCCTA	0.403		NA											19	114					0	0	0	0
LMLN	89782	broad.mit.edu	37	3	197746225	197746225	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:197746225A>T	uc011buo.1	+	12	1356	c.1334A>T	c.(1333-1335)AAG>ATG	p.K445M	LMLN_uc003fyt.2_Missense_Mutation_p.K430M|LMLN_uc010iar.2_Missense_Mutation_p.K482M|LMLN_uc010ias.2_Missense_Mutation_p.K393M|LMLN_uc003fyu.2_Missense_Mutation_p.K242M	NM_033029	NP_149018	Q96KR4	LMLN_HUMAN	leishmanolysin-like isoform 2	445					cell adhesion|cell division|mitosis|proteolysis	cytoplasm|membrane	metalloendopeptidase activity|zinc ion binding			skin(1)	1	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)	Lung NSC(153;0.132)	Epithelial(36;9.84e-24)|all cancers(36;3.18e-22)|OV - Ovarian serous cystadenocarcinoma(49;5.35e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.111)		AATTTGCAGAAGTTCCCTAAG	0.468		NA											16	67					0	0	0	0
NOP14	8602	broad.mit.edu	37	4	2958516	2958516	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:2958516A>G	uc003ggj.1	-	3	425	c.353T>C	c.(352-354)ATC>ACC	p.I118T	C4orf10_uc003ggi.1_Intron|NOP14_uc003ggk.3_Missense_Mutation_p.I118T|NOP14_uc003ggl.2_Missense_Mutation_p.I118T|NOP14_uc010icq.1_RNA	NM_003703	NP_003694	P78316	NOP14_HUMAN	probable nucleolar complex protein 14	118					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	mitochondrion|Noc4p-Nop14p complex|small-subunit processome	snoRNA binding			pancreas(1)	1						TAGATTGTAGATGCTTTTTTT	0.358		NA											7	40					0	0	0	0
OTOP1	133060	broad.mit.edu	37	4	4199579	4199579	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:4199579C>T	uc003ghp.1	-	5	1012	c.982G>A	c.(982-984)GTG>ATG	p.V328M		NM_177998	NP_819056	Q7RTM1	OTOP1_HUMAN	otopetrin 1	328	Helical; (Potential).				biomineral tissue development	extracellular space|integral to membrane				ovary(2)|central_nervous_system(1)	3				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		ACCACCACCACAGCAATGGTG	0.547		NA											24	52					0	0	0	0
C4orf6	10141	broad.mit.edu	37	4	5527953	5527953	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:5527953C>T	uc003gii.2	+	2	352	c.177C>T	c.(175-177)GAC>GAT	p.D59D		NM_005750	NP_005741	Q99440	CD006_HUMAN	chromosome 4 open reading frame 6	59					nervous system development						0						GAACTGCAGACACTGCAGATA	0.448		NA											18	51					0	0	0	0
JAKMIP1	152789	broad.mit.edu	37	4	6107405	6107405	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:6107405G>T	uc003giu.3	-	3	695	c.419C>A	c.(418-420)GCG>GAG	p.A140E	JAKMIP1_uc010idb.1_Missense_Mutation_p.A140E|JAKMIP1_uc010idc.1_Intron|JAKMIP1_uc010idd.1_Missense_Mutation_p.A140E|JAKMIP1_uc011bwc.1_Intron|JAKMIP1_uc003giv.3_Missense_Mutation_p.A140E|JAKMIP1_uc010ide.2_Missense_Mutation_p.A140E	NM_144720	NP_653321	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein	140	Potential.|Mediates association with microtubules.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4						GGCCCTGCGCGCCTCCTCGCG	0.701		NA											5	9					3.6e-05	5.62e-05	1	0
WFS1	7466	broad.mit.edu	37	4	6296916	6296916	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:6296916G>T	uc003giy.2	+	7	1027	c.861G>T	c.(859-861)AAG>AAT	p.K287N	WFS1_uc003gix.2_Missense_Mutation_p.K287N|WFS1_uc003giz.2_Missense_Mutation_p.K105N	NM_001145853	NP_001139325	O76024	WFS1_HUMAN	wolframin	287					endoplasmic reticulum calcium ion homeostasis|endoplasmic reticulum unfolded protein response|ER overload response|ER-associated protein catabolic process|glucose homeostasis|kidney development|negative regulation of neuron apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|polyubiquitinated misfolded protein transport|positive regulation of calcium ion transport|positive regulation of growth|positive regulation of protein ubiquitination|positive regulation of proteolysis|protein stabilization|renal water homeostasis|sensory perception of sound|visual perception	dendrite|integral to endoplasmic reticulum membrane	activating transcription factor binding|ATPase binding|transporter activity|ubiquitin protein ligase binding			central_nervous_system(2)	2				Colorectal(103;0.0512)		TGCGTCTGAAGGTGAGTGACC	0.657		NA											24	45					3.8e-20	7.72e-20	1	0
BOD1L	259282	broad.mit.edu	37	4	13605783	13605783	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:13605783G>T	uc003gmz.1	-	10	2858	c.2741C>A	c.(2740-2742)TCA>TAA	p.S914*	BOD1L_uc010idr.1_Nonsense_Mutation_p.S251*	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	914	Lys-rich.						DNA binding			ovary(5)|breast(1)	6						TTGAGTTTTTGATTTAGACTT	0.383		NA											34	103					4.32e-19	8.74e-19	1	0
CD38	952	broad.mit.edu	37	4	15780186	15780186	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:15780186G>T	uc011bxc.1	+	1	256	c.149G>T	c.(148-150)TGG>TTG	p.W50L	CD38_uc003goj.1_Missense_Mutation_p.W50L|CD38_uc003gol.1_Missense_Mutation_p.W50L	NM_001775	NP_001766	P28907	CD38_HUMAN	CD38 antigen	50	Extracellular (Potential).				B cell receptor signaling pathway|induction of apoptosis by extracellular signals|negative regulation of apoptosis|negative regulation of transcription, DNA-dependent|positive regulation of B cell proliferation|positive regulation of transcription, DNA-dependent|response to drug	integral to membrane|plasma membrane	binding|NAD+ nucleosidase activity|receptor activity			ovary(2)	2						CGCCAGCAGTGGAGCGGTCCG	0.617		NA											36	84					2.87e-16	5.64e-16	1	0
SLIT2	9353	broad.mit.edu	37	4	20255599	20255599	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:20255599C>A	uc003gpr.1	+	1	365	c.161C>A	c.(160-162)CCC>CAC	p.P54H	SLIT2_uc003gps.1_Missense_Mutation_p.P54H	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	54	LRRNT.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						AGGAATATCCCCCGCAACACC	0.667		NA											20	65					9.96e-16	1.94e-15	1	0
SLIT2	9353	broad.mit.edu	37	4	20568976	20568976	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:20568976C>T	uc003gpr.1	+	27	3021	c.2817C>T	c.(2815-2817)GAC>GAT	p.D939D	SLIT2_uc003gps.1_Silent_p.D931D	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	939	EGF-like 1.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						ATCCAGTTGACTTTTACCGAT	0.383		NA											32	79					0	0	0	0
ZCCHC4	29063	broad.mit.edu	37	4	25314461	25314461	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:25314461C>A	uc003grl.3	+	1	66	c.30C>A	c.(28-30)GCC>GCA	p.A10A		NM_024936	NP_079212	Q9H5U6	ZCHC4_HUMAN	zinc finger, CCHC domain containing 4	10							methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(2)	2		Breast(46;0.0503)				GGTTTGAAGCCGTGGAGGCAG	0.652		NA									OREG0016141	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	47	108					6.77e-33	1.43e-32	1	0
PCDH7	5099	broad.mit.edu	37	4	30725162	30725162	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:30725162C>T	uc003gsk.1	+	1	3126	c.2118C>T	c.(2116-2118)ACC>ACT	p.T706T	PCDH7_uc011bxw.1_Silent_p.T659T|PCDH7_uc011bxx.1_Silent_p.T706T	NM_002589	NP_002580	O60245	PCDH7_HUMAN	protocadherin 7 isoform a precursor	706	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|skin(1)	4						AACATCAGACCACATACACTT	0.443		NA											29	70					0	0	0	0
ARAP2	116984	broad.mit.edu	37	4	36230489	36230489	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:36230489C>G	uc003gsq.1	-	2	958	c.620G>C	c.(619-621)AGT>ACT	p.S207T	ARAP2_uc003gsr.1_Missense_Mutation_p.S207T	NM_015230	NP_056045	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	207					regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						AGGGAGCTTACTGAGATTTTC	0.338		NA											25	84					0	0	0	0
TBC1D1	23216	broad.mit.edu	37	4	37903767	37903767	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:37903767C>A	uc003gtb.2	+	2	394	c.51C>A	c.(49-51)GTC>GTA	p.V17V	TBC1D1_uc011byd.1_Silent_p.V17V|TBC1D1_uc010ifd.2_Silent_p.V17V	NM_015173	NP_055988	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family,	17						nucleus	Rab GTPase activator activity			ovary(1)	1						CTAACGAGGTCTCGGTGGATT	0.522		NA											31	73					3.99e-17	7.9e-17	1	0
KLB	152831	broad.mit.edu	37	4	39408952	39408952	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:39408952G>T	uc003gua.2	+	1	480	c.383G>T	c.(382-384)AGT>ATT	p.S128I	KLB_uc011byj.1_Missense_Mutation_p.S128I	NM_175737	NP_783864	Q86Z14	KLOTB_HUMAN	klotho beta	128	Extracellular (Potential).|Glycosyl hydrolase-1 1.				carbohydrate metabolic process	integral to membrane|plasma membrane	cation binding|fibroblast growth factor binding|hydrolase activity, hydrolyzing O-glycosyl compounds			skin(1)	1						AATGGTTCCAGTGACAGTTAT	0.398		NA											37	113					2.1e-21	4.28e-21	1	0
SLC30A9	10463	broad.mit.edu	37	4	42022531	42022531	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:42022531A>T	uc003gwl.2	+	4	579	c.433A>T	c.(433-435)AGT>TGT	p.S145C	SLC30A9_uc011byx.1_5'UTR	NM_006345	NP_006336	Q6PML9	ZNT9_HUMAN	solute carrier family 30 (zinc transporter),	145					nucleotide-excision repair|zinc ion transport	cytoskeleton|integral to membrane|nucleus	cation transmembrane transporter activity|nucleotide binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|ovary(1)	3						CCTCAAATCCAGGTAATTTTT	0.348		NA											30	67					0	0	0	0
KCTD8	386617	broad.mit.edu	37	4	44450416	44450416	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:44450416A>T	uc003gwu.2	-	1	409	c.125T>A	c.(124-126)TTC>TAC	p.F42Y		NM_198353	NP_938167	Q6ZWB6	KCTD8_HUMAN	potassium channel tetramerisation domain	42						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(2)|ovary(1)	3						TACTTCAGGGAAGGGCGAGGG	0.498		NA								HNSCC(17;0.042)			5	24					0	0	0	0
LRRC66	339977	broad.mit.edu	37	4	52860966	52860966	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:52860966C>A	uc003gzi.2	-	4	2235	c.2222G>T	c.(2221-2223)GGG>GTG	p.G741V		NM_001024611	NP_001019782	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	741						integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3						CTTGCTTGCCCCTGAGCTCTC	0.493		NA											37	96					9.63e-15	1.85e-14	1	0
PDGFRA	5156	broad.mit.edu	37	4	55139799	55139799	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:55139799G>C	uc003han.3	+	10	1791	c.1460G>C	c.(1459-1461)CGT>CCT	p.R487P	PDGFRA_uc003haa.2_Intron|PDGFRA_uc010igq.1_Missense_Mutation_p.R381P|PDGFRA_uc003ham.2_RNA	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	487	Ig-like C2-type 5.|Extracellular (Potential).				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	GTGGAGGGCCGTGTGACTTTC	0.522		NA	Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			28	78					0	0	0	0
KIT	3815	broad.mit.edu	37	4	55604710	55604710	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:55604710A>G	uc010igr.2	+	21	3005	c.2918A>G	c.(2917-2919)CAC>CGC	p.H973R	KIT_uc010igs.2_Missense_Mutation_p.H969R	NM_000222	NP_000213	P10721	KIT_HUMAN	v-kit Hardy-Zuckerman 4 feline sarcoma viral	973	Cytoplasmic (Potential).				male gonad development|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular space|integral to membrane	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity			soft_tissue(3273)|haematopoietic_and_lymphoid_tissue(1572)|skin(99)|testis(49)|bone(21)|genital_tract(18)|kidney(17)|ovary(16)|salivary_gland(15)|large_intestine(11)|thymus(6)|lung(6)|central_nervous_system(4)|NS(3)|eye(2)|endometrium(2)|breast(1)|stomach(1)|autonomic_ganglia(1)|pancreas(1)	5118	all_cancers(7;0.00453)|all_lung(4;0.000565)|Lung NSC(11;0.00129)|all_epithelial(27;0.0104)|Glioma(25;0.08)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(32;0.000276)|Epithelial(7;0.209)	Colorectal(1;0.0276)|COAD - Colon adenocarcinoma(1;0.171)	Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	CTGCTTGTGCACGACGATGTC	0.512		1	Mis|O		GIST|AML|TGCT|mastocytosis|mucosal melanoma	GIST|epithelioma	Piebald trait		Mast_Cell_disease_Familial_Clustering_of|Piebaldism|Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Gastrointestinal_Stromal_Tumors				46	111					0	0	0	0
AASDH	132949	broad.mit.edu	37	4	57215852	57215852	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:57215852A>T	uc003hbn.2	-	11	2218	c.2065T>A	c.(2065-2067)TCT>ACT	p.S689T	AASDH_uc010ihb.2_Missense_Mutation_p.S204T|AASDH_uc011caa.1_Missense_Mutation_p.S536T|AASDH_uc003hbo.2_Missense_Mutation_p.S589T|AASDH_uc011cab.1_Missense_Mutation_p.S204T|AASDH_uc010ihc.2_Missense_Mutation_p.S689T|AASDH_uc003hbp.2_Missense_Mutation_p.S689T	NM_181806	NP_861522	Q4L235	ACSF4_HUMAN	aminoadipate-semialdehyde dehydrogenase	689					fatty acid metabolic process		acid-thiol ligase activity|acyl carrier activity|ATP binding|cofactor binding			ovary(4)	4	Glioma(25;0.08)|all_neural(26;0.101)	all_hematologic(202;0.0017)				GAATTCAGAGACAAAATTTGA	0.393		NA											24	79					0	0	0	0
TECRL	253017	broad.mit.edu	37	4	65275045	65275045	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:65275045C>A	uc003hcv.2	-	1	134	c.25G>T	c.(25-27)GCT>TCT	p.A9S	TECRL_uc003hcw.2_Missense_Mutation_p.A9S	NM_001010874	NP_001010874	Q5HYJ1	TECRL_HUMAN	steroid 5 alpha-reductase 2-like 2	9					lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors				0						CGTTCCGAAGCGAGGGACTTG	0.393		NA											25	57					4.6e-10	8.2e-10	1	0
EPHA5	2044	broad.mit.edu	37	4	66356139	66356139	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:66356139C>G	uc003hcy.2	-	5	1551	c.1358G>C	c.(1357-1359)GGA>GCA	p.G453A	EPHA5_uc003hcx.2_Missense_Mutation_p.G384A|EPHA5_uc003hcz.2_Missense_Mutation_p.G453A|EPHA5_uc011cah.1_Missense_Mutation_p.G453A|EPHA5_uc011cai.1_Missense_Mutation_p.G453A|EPHA5_uc003hda.2_Missense_Mutation_p.G453A	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	453	Fibronectin type-III 1.|Extracellular (Potential).				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						CTGCCGGGCTCCTGGGCTCAA	0.468		NA								TSP Lung(17;0.13)			21	58					0	0	0	0
TMPRSS11F	389208	broad.mit.edu	37	4	68919756	68919756	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:68919756A>T	uc003hdt.1	-	10	1237	c.1188T>A	c.(1186-1188)GAT>GAA	p.D396E	LOC550112_uc003hdl.3_Intron|uc011cak.1_Intron	NM_207407	NP_997290	Q6ZWK6	TM11F_HUMAN	transmembrane protease, serine 11F	396	Peptidase S1.|Extracellular (Potential).				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			ovary(1)	1						TGTCATGATTATCATAAACCA	0.368		NA											16	45					0	0	0	0
UGT2B11	10720	broad.mit.edu	37	4	70080161	70080161	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:70080161C>A	uc003heh.2	-	1	289	c.280G>T	c.(280-282)GTT>TTT	p.V94F	uc003hei.1_Intron	NM_001073	NP_001064	O75310	UDB11_HUMAN	UDP glucuronosyltransferase 2 family,	94					estrogen metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	3						CATCTCTTAACCTGTTGCATG	0.313		NA											48	118					4.64e-19	9.38e-19	1	0
CSN2	1447	broad.mit.edu	37	4	70823471	70823471	+	Missense_Mutation	SNP	A	A	T	rs139725489		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:70823471A>T	uc003hes.3	-	5	209	c.196T>A	c.(196-198)TAT>AAT	p.Y66N	CSN2_uc003het.3_Missense_Mutation_p.Y65N	NM_001891	NP_001882	P05814	CASB_HUMAN	casein beta precursor	66					calcium ion transport	extracellular region	calcium ion binding|enzyme inhibitor activity|transporter activity				0						ACGAATGGATAGATCAGAGGC	0.443		NA											21	56					0	0	0	0
ADAMTS3	9508	broad.mit.edu	37	4	73205293	73205293	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:73205293A>T	uc003hgk.1	-	5	816	c.779T>A	c.(778-780)GTA>GAA	p.V260E		NM_014243	NP_055058	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1	260	Peptidase M12B.				collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TCCCAGCAGTACCTCGATATT	0.478		NA											84	239					0	0	0	0
AFP	174	broad.mit.edu	37	4	74318195	74318195	+	Silent	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:74318195T>A	uc003hgz.1	+	12	1553	c.1506T>A	c.(1504-1506)ACT>ACA	p.T502T	AFP_uc003hha.1_Silent_p.T502T|AFP_uc011cbg.1_Silent_p.T276T	NM_001134	NP_001125	P02771	FETA_HUMAN	alpha-fetoprotein precursor	502	Albumin 3.				transport		metal ion binding			ovary(1)	1	Breast(15;0.00102)		Epithelial(6;2.42e-05)|all cancers(17;0.000268)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			AGTGCTGCACTTCTTCATATG	0.443		NA							Alpha-Fetoprotein_Hereditary_Persistence_of				27	76					0	0	0	0
HERC5	51191	broad.mit.edu	37	4	89407376	89407377	+	Missense_Mutation	DNP	TG	TG	CT			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:89407376_89407377TG>CT	uc003hrt.2	+	14	2001_2002	c.1848_1849TG>CT	c.(1846-1851)ACTGTG>ACCTTG	p.V617L	HERC5_uc011cdm.1_Missense_Mutation_p.V255L	NM_016323	NP_057407	Q9UII4	HERC5_HUMAN	hect domain and RLD 5	617					innate immune response|ISG15-protein conjugation|negative regulation of type I interferon production|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cyclin-dependent protein kinase activity|regulation of defense response to virus|response to virus	cytosol|perinuclear region of cytoplasm	ISG15 ligase activity|protein binding|ubiquitin-protein ligase activity	p.T616T(1)		ovary(4)|lung(3)|skin(2)	9		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000209)		GGAAAATGACTGTGGTAGGTAT	0.312		NA											13	32					0	0	0	0
GRID2	2895	broad.mit.edu	37	4	94006343	94006343	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:94006343C>A	uc011cdt.1	+	3	700	c.442C>A	c.(442-444)CCA>ACA	p.P148T	GRID2_uc010ikx.2_Missense_Mutation_p.P148T|GRID2_uc011cdu.1_Intron|GRID2_uc011cdv.1_RNA	NM_001510	NP_001501	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	148	Extracellular (Potential).				glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	CTCAGTTCGCCCACCTGTCTA	0.478		NA											29	77					7.26e-15	1.4e-14	1	0
PDHA2	5161	broad.mit.edu	37	4	96761796	96761796	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:96761796C>A	uc003htr.3	+	1	558	c.495C>A	c.(493-495)GTC>GTA	p.V165V		NM_005390	NP_005381	P29803	ODPAT_HUMAN	pyruvate dehydrogenase E1 alpha 2 precursor	165					glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	ATGGCATCGTCGGTGCACAGG	0.507		NA											26	69					3.29e-13	6.16e-13	1	0
BANK1	55024	broad.mit.edu	37	4	102951361	102951361	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:102951361C>A	uc003hvy.3	+	10	2113	c.1839C>A	c.(1837-1839)GCC>GCA	p.A613A	BANK1_uc003hvx.3_Silent_p.A598A|BANK1_uc010ill.2_Silent_p.A480A|BANK1_uc003hvz.3_Silent_p.A583A	NM_017935	NP_060405	Q8NDB2	BANK1_HUMAN	B-cell scaffold protein with ankyrin repeats 1	613					B cell activation					ovary(2)|skin(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)		GACCTCCTGCCCCCACACCCC	0.373		NA											25	48					6.33e-13	1.18e-12	1	0
LEF1	51176	broad.mit.edu	37	4	109088901	109088901	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:109088901C>T	uc003hyt.1	-	1	678	c.23G>A	c.(22-24)GGT>GAT	p.G8D	LEF1_uc011cfj.1_5'Flank|LEF1_uc011cfk.1_5'Flank|LEF1_uc003hyu.1_Missense_Mutation_p.G8D|LEF1_uc003hyv.1_Missense_Mutation_p.G8D|LEF1_uc010imb.1_RNA	NM_016269	NP_057353	Q9UJU2	LEF1_HUMAN	lymphoid enhancer-binding factor 1 isoform 1	8	Poly-Gly.|CTNNB1-binding (By similarity).				canonical Wnt receptor signaling pathway|cell chemotaxis|cellular response to interleukin-4|epithelial to mesenchymal transition|histone H3 acetylation|histone H4 acetylation|negative regulation of apoptosis in bone marrow|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell-cell adhesion|negative regulation of DNA binding|negative regulation of estrogen receptor binding|negative regulation of interleukin-13 production|negative regulation of interleukin-4 production|negative regulation of interleukin-5 production|negative regulation of transcription, DNA-dependent|neutrophil differentiation|osteoblast differentiation|palate development|positive regulation by host of viral transcription|positive regulation of cell cycle process|positive regulation of cell growth|positive regulation of cell migration|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of cell proliferation in bone marrow|positive regulation of cell-cell adhesion|positive regulation of epithelial to mesenchymal transition|positive regulation of granulocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|T-helper 1 cell differentiation	cytoplasm|protein-DNA complex|transcription factor complex	armadillo repeat domain binding|beta-catenin binding|C2H2 zinc finger domain binding|caspase inhibitor activity|DNA bending activity|enhancer binding|estrogen receptor activity|estrogen receptor binding|gamma-catenin binding|histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding			large_intestine(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.000224)		GCCGCCGCCACCTCCTCCGGA	0.642		NA											33	83					0	0	0	0
ENPEP	2028	broad.mit.edu	37	4	111470910	111470910	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:111470910G>T	uc003iab.3	+	17	2711	c.2369G>T	c.(2368-2370)GGG>GTG	p.G790V		NM_001977	NP_001968	Q07075	AMPE_HUMAN	glutamyl aminopeptidase	790	Extracellular (Potential).				cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			skin(3)|ovary(1)|breast(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	TATCGGTATGGGATGCAGAAC	0.388		NA											16	62					2e-07	3.35e-07	1	0
ANK2	287	broad.mit.edu	37	4	114274328	114274328	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:114274328C>A	uc003ibe.3	+	38	4654	c.4554C>A	c.(4552-4554)ACC>ACA	p.T1518T	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_5'Flank|ANK2_uc011cgb.1_Silent_p.T1533T	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	1485					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TCAAAATGACCGCCATCTTGA	0.458		NA											26	70					9.39e-14	1.78e-13	1	0
C4orf31	79625	broad.mit.edu	37	4	121958113	121958113	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:121958113G>C	uc003idq.1	-	4	1540	c.1013C>G	c.(1012-1014)GCC>GGC	p.A338G		NM_024574	NP_078850	Q8TB73	CD031_HUMAN	hypothetical protein LOC79625 precursor	338											0						CTTCTGTTTGGCTTCTTCCTT	0.438		NA											22	71					0	0	0	0
INPP4B	8821	broad.mit.edu	37	4	142950038	142950038	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:142950038T>C	uc003iix.3	-	27	3267	c.2672A>G	c.(2671-2673)AAG>AGG	p.K891R	INPP4B_uc003iiw.3_Missense_Mutation_p.K891R|INPP4B_uc011chm.1_RNA	NM_003866	NP_003857	O15327	INP4B_HUMAN	inositol polyphosphate-4-phosphatase, type II,	891					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			ovary(1)|lung(1)	2	all_hematologic(180;0.158)					TTTGATATTCTTCAGTACATT	0.393		NA											11	31					0	0	0	0
INPP4B	8821	broad.mit.edu	37	4	143235901	143235901	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:143235901G>T	uc003iix.3	-	9	982	c.387C>A	c.(385-387)GTC>GTA	p.V129V	INPP4B_uc003iiw.3_Silent_p.V129V|INPP4B_uc011chm.1_RNA|INPP4B_uc011cho.1_RNA	NM_003866	NP_003857	O15327	INP4B_HUMAN	inositol polyphosphate-4-phosphatase, type II,	129	C2.				signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			ovary(1)|lung(1)	2	all_hematologic(180;0.158)					GTTCTGGTAGGACACTGGTTC	0.433		NA											36	99					9.18e-22	1.88e-21	1	0
GYPB	2994	broad.mit.edu	37	4	144920591	144920591	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:144920591G>T	uc003ijm.1	-	3	204	c.148C>A	c.(148-150)CAA>AAA	p.Q50K	GYPA_uc003ijn.2_Intron|GYPB_uc011chs.1_RNA|GYPB_uc011cht.1_RNA|GYPB_uc011chu.1_RNA|GYPB_uc010ioo.1_RNA|GYPB_uc010iop.2_RNA|GYPB_uc011chv.1_RNA|GYPB_uc011chw.1_RNA|GYPB_uc011chx.1_Intron|GYPB_uc011chy.1_RNA|GYPB_uc011chz.1_RNA	NM_002100	NP_002091	P06028	GLPB_HUMAN	glycophorin B precursor	50	Extracellular (Potential).					integral to plasma membrane					0	all_hematologic(180;0.158)					TGGACAAGTTGTCCCGTTTCT	0.328		NA											4	11					0.00024832	0.000374451	1	0
GYPA	2993	broad.mit.edu	37	4	145035886	145035886	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:145035886G>T	uc003ijo.3	-	6	508	c.392C>A	c.(391-393)CCT>CAT	p.P131H	GYPA_uc003ijn.2_Intron|GYPA_uc011cia.1_RNA|GYPA_uc011cib.1_Missense_Mutation_p.P98H|GYPA_uc003ijp.3_Missense_Mutation_p.P99H|GYPA_uc010ioq.2_Missense_Mutation_p.P118H|GYPA_uc010ior.2_Missense_Mutation_p.P66H|GYPA_uc010ios.1_RNA	NM_002099	NP_002090	P02724	GLPA_HUMAN	glycophorin A precursor	131	Cytoplasmic.				interspecies interaction between organisms	membrane fraction	receptor activity			central_nervous_system(2)	2	all_hematologic(180;0.15)					GTCTGTGTCAGGTGAGGGGAG	0.328		NA											13	31					7.93e-07	1.31e-06	1	0
KIAA0922	23240	broad.mit.edu	37	4	154525579	154525579	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:154525579A>T	uc003inm.3	+	25	3464	c.3412A>T	c.(3412-3414)AAT>TAT	p.N1138Y	KIAA0922_uc010ipp.2_Missense_Mutation_p.N1139Y|KIAA0922_uc010ipq.2_Missense_Mutation_p.N907Y	NM_015196	NP_056011	A2VDJ0	T131L_HUMAN	hypothetical protein LOC23240 isoform 2	1138	Cytoplasmic (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	all_hematologic(180;0.093)	Renal(120;0.118)				CAGGAAAAATAATGGTAATCT	0.403		NA											9	33					0	0	0	0
DCHS2	54798	broad.mit.edu	37	4	155163899	155163899	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:155163899C>A	uc003inw.2	-	22	5602	c.5602G>T	c.(5602-5604)GGG>TGG	p.G1868W		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	1868	Cadherin 16.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		CTGGGCATCCCTTTATCTGTG	0.383		NA											14	28					1.57e-10	2.84e-10	1	0
FGA	2243	broad.mit.edu	37	4	155505381	155505381	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:155505381G>C	uc003iod.1	-	6	2554	c.2496C>G	c.(2494-2496)AAC>AAG	p.N832K		NM_000508	NP_000499	P02671	FIBA_HUMAN	fibrinogen, alpha polypeptide isoform alpha-E	832	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|breast(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	CATAAGGACTGTTATTCCTTG	0.498		NA											34	100					0	0	0	0
LRAT	9227	broad.mit.edu	37	4	155665738	155665738	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:155665738G>T	uc003iom.1	+	1	587	c.260G>T	c.(259-261)CGC>CTC	p.R87L	uc003iol.2_Intron|LRAT_uc003ion.1_Missense_Mutation_p.R87L	NM_004744	NP_004735	O95237	LRAT_HUMAN	lecithin retinol acyltransferase	87	Cytoplasmic (By similarity).				response to stimulus|retinoid metabolic process|steroid metabolic process|visual perception	endoplasmic reticulum membrane|integral to membrane|multivesicular body|perinuclear region of cytoplasm|rough endoplasmic reticulum	phosphatidylcholine-retinol O-acyltransferase activity			central_nervous_system(1)	1	all_hematologic(180;0.215)	Renal(120;0.0458)			Vitamin A(DB00162)	GACATGGGGCGCACGCAGAAG	0.597		NA											20	51					1.56e-12	2.89e-12	1	0
GUCY1B3	2983	broad.mit.edu	37	4	156696131	156696131	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:156696131A>T	uc003ipc.2	+	3	256	c.89A>T	c.(88-90)CAG>CTG	p.Q30L	GUCY1B3_uc011cio.1_Missense_Mutation_p.Q30L|GUCY1B3_uc011cip.1_Missense_Mutation_p.Q10L|GUCY1B3_uc003ipd.2_5'UTR|GUCY1B3_uc010iqf.2_Missense_Mutation_p.Q30L|GUCY1B3_uc010iqg.2_5'UTR|GUCY1B3_uc011ciq.1_5'UTR	NM_000857	NP_000848	Q02153	GCYB1_HUMAN	guanylate cyclase 1, soluble, beta 3	30					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble|intracellular membrane-bounded organelle	GTP binding|guanylate cyclase activity|receptor activity				0	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.148)		AAAGAGGCACAGTTAGATGAA	0.318		NA											41	92					0	0	0	0
GRIA2	2891	broad.mit.edu	37	4	158256999	158256999	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:158256999G>T	uc003ipm.3	+	10	1902	c.1443G>T	c.(1441-1443)TGG>TGT	p.W481C	GRIA2_uc011cit.1_Missense_Mutation_p.W434C|GRIA2_uc003ipl.3_Missense_Mutation_p.W481C|GRIA2_uc003ipk.3_Missense_Mutation_p.W434C|GRIA2_uc010iqh.1_RNA	NM_001083619	NP_001077088	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2 isoform 2	481	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			central_nervous_system(3)|ovary(1)	4	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	CGAAAATTTGGAATGGGATGG	0.433		NA											5	11					1.02e-07	1.73e-07	1	0
TKTL2	84076	broad.mit.edu	37	4	164394427	164394427	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:164394427T>C	uc003iqp.3	-	1	621	c.460A>G	c.(460-462)ATG>GTG	p.M154V		NM_032136	NP_115512	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	154						cytoplasm	metal ion binding|transketolase activity			ovary(2)|skin(2)|pancreas(1)	5	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				CCATCTCCCATAAGGCAGAAC	0.542		NA											30	80					0	0	0	0
GALNTL6	442117	broad.mit.edu	37	4	173873316	173873316	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:173873316G>T	uc003isv.2	+	10	2014	c.1278G>T	c.(1276-1278)AAG>AAT	p.K426N		NM_001034845	NP_001030017	Q49A17	GLTL6_HUMAN	N-acetylgalactosaminyltransferase-like 6	426	Lumenal (Potential).					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|ovary(1)|skin(1)	4						AGCAGCTCAAGTGCAAGGACT	0.597		NA											15	37					2.32e-05	3.65e-05	1	0
WWC2	80014	broad.mit.edu	37	4	184186193	184186193	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:184186193G>T	uc010irx.2	+	12	2154	c.1972G>T	c.(1972-1974)GTG>TTG	p.V658L	WWC2_uc003ivk.3_Missense_Mutation_p.V453L|WWC2_uc003ivl.3_RNA|WWC2_uc010iry.2_Missense_Mutation_p.V340L|WWC2_uc003ivn.3_Missense_Mutation_p.V173L|WWC2_uc010irz.2_5'Flank	NM_024949	NP_079225	Q6AWC2	WWC2_HUMAN	WW and C2 domain containing 2	658										ovary(2)|lung(1)	3		all_lung(41;5.28e-14)|Lung NSC(41;1.35e-13)|Colorectal(36;0.00681)|Hepatocellular(41;0.00886)|Renal(120;0.00992)|Prostate(90;0.0237)|all_hematologic(60;0.0592)|Esophageal squamous(56;0.179)|all_neural(102;0.202)		all cancers(43;3.38e-24)|Epithelial(43;1.4e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.09e-09)|GBM - Glioblastoma multiforme(59;3.33e-05)|Colorectal(24;3.58e-05)|STAD - Stomach adenocarcinoma(60;4.21e-05)|COAD - Colon adenocarcinoma(29;0.000171)|LUSC - Lung squamous cell carcinoma(40;0.0145)|READ - Rectum adenocarcinoma(43;0.242)		AACCACTTGTGTGTCGGCTGC	0.483		NA											15	24					1.52e-12	2.82e-12	1	0
SORBS2	8470	broad.mit.edu	37	4	186533086	186533086	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:186533086C>T	uc003iyl.2	-	18	3790	c.2932G>A	c.(2932-2934)GGT>AGT	p.G978S	SORBS2_uc003iyh.2_Missense_Mutation_p.G702S|SORBS2_uc011ckw.1_Missense_Mutation_p.G539S|SORBS2_uc003iyi.2_Missense_Mutation_p.G609S|SORBS2_uc011ckx.1_Missense_Mutation_p.G544S|SORBS2_uc003iyk.2_Missense_Mutation_p.G522S|SORBS2_uc003iym.2_Missense_Mutation_p.G1078S|SORBS2_uc003iyn.1_Missense_Mutation_p.G569S|SORBS2_uc011cku.1_Missense_Mutation_p.G370S|SORBS2_uc011ckv.1_Missense_Mutation_p.G882S|SORBS2_uc003iyd.2_Missense_Mutation_p.G677S|SORBS2_uc003iye.2_Missense_Mutation_p.G551S|SORBS2_uc003iya.2_Missense_Mutation_p.G498S|SORBS2_uc003iyb.2_Missense_Mutation_p.G451S|SORBS2_uc003iyc.2_Missense_Mutation_p.G431S|SORBS2_uc003iyg.2_Missense_Mutation_p.G1092S|SORBS2_uc003iyf.2_Missense_Mutation_p.G514S|SORBS2_uc003iyo.1_Missense_Mutation_p.G427S	NM_021069	NP_066547	O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2 isoform 2	978	SH3 2.					actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(1)	1		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		GGGATTTTACCTTCATACCAG	0.398		NA											9	41					0	0	0	0
ZFP42	132625	broad.mit.edu	37	4	188924241	188924241	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:188924241T>A	uc003izg.1	+	3	525	c.280T>A	c.(280-282)TCC>ACC	p.S94T	ZFP42_uc003izh.1_Missense_Mutation_p.S94T|ZFP42_uc003izi.1_Missense_Mutation_p.S94T	NM_174900	NP_777560	Q96MM3	ZFP42_HUMAN	zinc finger protein 42	94					female gonad development|male gonad development|meiosis	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2		all_cancers(14;6.2e-52)|all_epithelial(14;7.36e-37)|all_lung(41;2.29e-15)|Lung NSC(41;6.7e-15)|Breast(6;1.53e-05)|Melanoma(20;3.01e-05)|Hepatocellular(41;0.00335)|all_hematologic(60;0.014)|Renal(120;0.0183)|Prostate(90;0.0421)|Colorectal(36;0.227)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;4.21e-06)|GBM - Glioblastoma multiforme(59;8.93e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.157)		ACTTTTTGAGTCCTTGGAATA	0.428		NA											34	58					0	0	0	0
TRIML2	205860	broad.mit.edu	37	4	189018271	189018271	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:189018271G>T	uc003izl.2	-	6	575	c.539C>A	c.(538-540)ACA>AAA	p.T180K	TRIML2_uc003izj.1_5'UTR|TRIML2_uc003izk.1_5'UTR|TRIML2_uc011cle.1_Missense_Mutation_p.T255K	NM_173553	NP_775824	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	180							ligase activity			central_nervous_system(2)	2		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		ACTCAGGTCTGTGATATGAGC	0.498		NA											31	95					4.75e-14	9.02e-14	1	0
TRIML1	339976	broad.mit.edu	37	4	189060957	189060957	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:189060957G>T	uc003izm.1	+	1	360	c.245G>T	c.(244-246)CGG>CTG	p.R82L		NM_178556	NP_848651	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	82					multicellular organismal development		ligase activity|zinc ion binding			ovary(1)|pancreas(1)|breast(1)|skin(1)	4		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		AGGCAGCTCCGGTCCCAGGTG	0.637		NA											18	48					6.94e-10	1.24e-09	1	0
ADCY2	108	broad.mit.edu	37	5	7789793	7789793	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:7789793C>A	uc003jdz.1	+	20	2575	c.2508C>A	c.(2506-2508)AAC>AAA	p.N836K	ADCY2_uc011cmo.1_Missense_Mutation_p.N656K|ADCY2_uc010itm.1_Missense_Mutation_p.N32K	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	836	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						TATGGAAGAACAAATTCAAAA	0.483		NA											26	93					2.13e-12	3.93e-12	1	0
DNAH5	1767	broad.mit.edu	37	5	13788868	13788868	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:13788868G>T	uc003jfd.2	-	51	8646	c.8604C>A	c.(8602-8604)GAC>GAA	p.D2868E		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2868					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CAAAATATGTGTCAATTCCAC	0.413		NA							Kartagener_syndrome				26	83					2.45e-14	4.67e-14	1	0
DNAH5	1767	broad.mit.edu	37	5	13864714	13864714	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:13864714C>A	uc003jfd.2	-	28	4430	c.4388G>T	c.(4387-4389)TGG>TTG	p.W1463L		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1463	Potential.|Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					AAAAGCCTGCCAGTCCTTCAA	0.507		NA							Kartagener_syndrome				23	51					9.96e-16	1.94e-15	1	0
TRIO	7204	broad.mit.edu	37	5	14488346	14488346	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:14488346G>T	uc003jff.2	+	48	7615	c.7609G>T	c.(7609-7611)GTG>TTG	p.V2537L	TRIO_uc003jfg.2_Intron|TRIO_uc003jfh.1_Missense_Mutation_p.V2186L	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	2537					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					CGAGCAGTCCGTGCAGTCCAC	0.721		NA											7	14					8.13e-05	0.000124651	1	0
CDH10	1008	broad.mit.edu	37	5	24537561	24537561	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:24537561C>A	uc003jgr.1	-	3	786	c.454G>T	c.(454-456)GAT>TAT	p.D152Y	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	152	Cadherin 1.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		TCATTGATATCATGAATTTTG	0.413		NA								HNSCC(23;0.051)			45	100					2.25e-16	4.43e-16	1	0
CDH6	1004	broad.mit.edu	37	5	31323216	31323216	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:31323216C>A	uc003jhe.1	+	12	2500	c.2174C>A	c.(2173-2175)ACG>AAG	p.T725K		NM_004932	NP_004923	P55285	CADH6_HUMAN	cadherin 6, type 2 preproprotein	725	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			ovary(4)|skin(2)|large_intestine(1)	7						GAAAATGACACGGACCCCACT	0.562		NA											13	35					0.00010058	0.000153788	1	0
TARS	6897	broad.mit.edu	37	5	33457373	33457373	+	Silent	SNP	G	G	A	rs113811412		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:33457373G>A	uc003jhy.2	+	9	1144	c.849G>A	c.(847-849)ACG>ACA	p.T283T	TARS_uc011cob.1_Silent_p.T271T|TARS_uc010iup.1_Silent_p.T224T|TARS_uc011coc.1_Silent_p.T304T|TARS_uc003jhz.2_Silent_p.T179T|TARS_uc011cod.1_Silent_p.T162T	NM_152295	NP_689508	P26639	SYTC_HUMAN	threonyl-tRNA synthetase	283					threonyl-tRNA aminoacylation	cytosol	ATP binding|protein homodimerization activity|threonine-tRNA ligase activity			ovary(2)	2					L-Threonine(DB00156)	ATTCCTCCACGTACTGGGAAG	0.388		NA											11	38					0	0	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33643537	33643537	+	Silent	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:33643537A>G	uc003jia.1	-	10	1681	c.1518T>C	c.(1516-1518)TTT>TTC	p.F506F	ADAMTS12_uc010iuq.1_Silent_p.F506F	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	506	Disintegrin.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						TAGAGCGACAAAAGCCCTTCA	0.498		NA								HNSCC(64;0.19)			28	79					0	0	0	0
UGT3A1	133688	broad.mit.edu	37	5	35991303	35991303	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:35991303G>T	uc003jjv.1	-	1	197	c.40C>A	c.(40-42)CTT>ATT	p.L14I	UGT3A1_uc003jjw.1_RNA|UGT3A1_uc011coq.1_Missense_Mutation_p.L14I|UGT3A1_uc011cor.1_Missense_Mutation_p.L14I|UGT3A1_uc003jjy.1_Intron	NM_152404	NP_689617	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	14						integral to membrane	glucuronosyltransferase activity			ovary(2)|central_nervous_system(1)	3	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			ACCCCAGAAAGAAGGAAGGCC	0.612		NA											33	79					6.01e-18	1.2e-17	1	0
RANBP3L	202151	broad.mit.edu	37	5	36260950	36260950	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:36260950C>T	uc003jkh.2	-	8	1094	c.601G>A	c.(601-603)GAT>AAT	p.D201N	RANBP3L_uc011cow.1_Missense_Mutation_p.D226N	NM_145000	NP_659437	Q86VV4	RNB3L_HUMAN	RAN binding protein 3-like isoform 2	201					intracellular transport					ovary(1)	1	all_lung(31;4.52e-05)		Epithelial(62;0.0543)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.149)|Colorectal(62;0.202)			GAACATTTATCTTCATTTGGT	0.249		NA											3	10					0	0	0	0
C5orf42	65250	broad.mit.edu	37	5	37181062	37181062	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:37181062C>A	uc011cpa.1	-	27	5698	c.5467G>T	c.(5467-5469)GAG>TAG	p.E1823*	C5orf42_uc011coy.1_Nonsense_Mutation_p.E324*|C5orf42_uc003jks.2_RNA|C5orf42_uc011coz.1_Nonsense_Mutation_p.E898*	NM_023073	NP_075561	E9PH94	E9PH94_HUMAN	hypothetical protein LOC65250	1823										ovary(4)|breast(2)|skin(1)	7	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			CTCTCCCTCTCAATATTGGGT	0.388		NA											9	33					4.69e-08	7.99e-08	1	0
EGFLAM	133584	broad.mit.edu	37	5	38438424	38438424	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:38438424C>T	uc003jlc.1	+	17	2655	c.2331C>T	c.(2329-2331)TCC>TCT	p.S777S	EGFLAM_uc003jlb.1_Silent_p.S777S|EGFLAM_uc003jle.1_Silent_p.S543S|EGFLAM_uc003jlf.1_Silent_p.S143S	NM_152403	NP_689616	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G	777	Laminin G-like 2.					cell junction|proteinaceous extracellular matrix|synapse				pancreas(3)|skin(3)|ovary(1)	7	all_lung(31;0.000385)					ACTTCACCTCCGGAGTGAATG	0.512		NA											15	43					0	0	0	0
C9	735	broad.mit.edu	37	5	39342218	39342218	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:39342218T>A	uc003jlv.3	-	2	247	c.158A>T	c.(157-159)CAA>CTA	p.Q53L		NM_001737	NP_001728	P02748	CO9_HUMAN	complement component 9 precursor	53	TSP type-1.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis|hemolysis by symbiont of host erythrocytes	extracellular region|membrane attack complex					0	all_lung(31;0.000197)	all_neural(839;7.57e-10)|Lung NSC(810;2.62e-08)|Ovarian(839;0.00384)|Breast(839;0.0184)|Myeloproliferative disorder(839;0.0511)	Epithelial(62;0.158)			AGGATCGCATTGTGACCATTC	0.463		NA											15	66					0	0	0	0
SLC38A9	153129	broad.mit.edu	37	5	54945036	54945036	+	Silent	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:54945036T>C	uc003jqf.2	-	11	1260	c.1059A>G	c.(1057-1059)CCA>CCG	p.P353P	SLC38A9_uc003jqd.2_Silent_p.P290P|SLC38A9_uc010ivx.2_Intron|SLC38A9_uc003jqe.2_RNA|SLC38A9_uc010ivy.2_Silent_p.P224P	NM_173514	NP_775785	Q8NBW4	S38A9_HUMAN	solute carrier family 38, member 9	353					amino acid transport|sodium ion transport	integral to membrane					0		Lung NSC(810;0.00122)|Prostate(74;0.0376)|Breast(144;0.181)				AAAGCTCACCTGGTACAAAAA	0.303		NA											6	12					0	0	0	0
BDP1	55814	broad.mit.edu	37	5	70819984	70819984	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:70819984G>T	uc003kbp.1	+	25	5869	c.5606G>T	c.(5605-5607)CGG>CTG	p.R1869L	BDP1_uc003kbo.2_Missense_Mutation_p.R1869L|BDP1_uc003kbq.1_RNA	NM_018429	NP_060899	A6H8Y1	BDP1_HUMAN	transcription factor-like nuclear regulator	1869					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			skin(2)	2		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		GTGACTCTTCGGGCTTCCCAG	0.468		NA											36	94					2.27e-22	4.66e-22	1	0
TMEM171	134285	broad.mit.edu	37	5	72427521	72427521	+	Silent	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:72427521A>T	uc003kcm.2	+	4	1143	c.939A>T	c.(937-939)ACA>ACT	p.T313T	TMEM171_uc003kcn.3_Silent_p.T312T	NM_173490	NP_775761	Q8WVE6	TM171_HUMAN	transmembrane protein 171 isoform 1	313						integral to membrane					0		Lung NSC(167;0.0378)|Ovarian(174;0.0908)|Prostate(461;0.165)		OV - Ovarian serous cystadenocarcinoma(47;1.87e-54)|Lung(70;0.115)		CTGCAGCTACATTCTTGCCTC	0.378		NA											37	67					0	0	0	0
BHMT2	23743	broad.mit.edu	37	5	78378765	78378765	+	Missense_Mutation	SNP	G	G	A	rs147230129		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:78378765G>A	uc003kft.2	+	5	607	c.584G>A	c.(583-585)AGG>AAG	p.R195K	BHMT2_uc011cth.1_Missense_Mutation_p.R131K	NM_017614	NP_060084	Q9H2M3	BHMT2_HUMAN	betaine-homocysteine methyltransferase 2	195	Hcy-binding.				methionine biosynthetic process	cytoplasm	betaine-homocysteine S-methyltransferase activity|homocysteine S-methyltransferase activity|zinc ion binding			ovary(1)	1		all_lung(232;0.00063)|Lung NSC(167;0.00171)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;2.09e-45)|Epithelial(54;9.3e-41)|all cancers(79;4.09e-36)	L-Methionine(DB00134)	TGTGCTGTGAGGCTGGTGAAG	0.463		NA											50	114					0	0	0	0
CMYA5	202333	broad.mit.edu	37	5	79034639	79034639	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:79034639C>A	uc003kgc.2	+	2	10123	c.10051C>A	c.(10051-10053)CGT>AGT	p.R3351S		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	3351						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		TGTTCTGGAGCGTGCAGATGA	0.488		NA											21	46					4.35e-09	7.58e-09	1	0
SERINC5	256987	broad.mit.edu	37	5	79470855	79470855	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:79470855C>T	uc003kgj.2	-	5	602	c.473G>A	c.(472-474)GGA>GAA	p.G158E	SERINC5_uc003kgk.2_Missense_Mutation_p.G158E|SERINC5_uc003kgl.2_RNA|SERINC5_uc003kgm.2_Missense_Mutation_p.G158E|SERINC5_uc011ctj.1_Missense_Mutation_p.G158E	NM_178276	NP_840060	Q86VE9	SERC5_HUMAN	developmentally regulated protein TPO1	158	Helical; (Potential).				phosphatidylserine metabolic process|phospholipid biosynthetic process|positive regulation of transferase activity	endoplasmic reticulum membrane|integral to membrane				ovary(1)	1		Lung NSC(167;0.00328)|all_lung(232;0.00356)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;2.93e-46)|Epithelial(54;5.59e-40)|all cancers(79;1.89e-34)		TCCGACGGCTCCCACATAGCG	0.468		NA											5	8					0	0	0	0
ANKRD34B	340120	broad.mit.edu	37	5	79855120	79855120	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:79855120G>T	uc010jam.2	-	4	1069	c.719C>A	c.(718-720)CCC>CAC	p.P240H	ANKRD34B_uc003kgw.2_Missense_Mutation_p.P240H|ANKRD34B_uc010jan.2_Missense_Mutation_p.P240H	NM_001004441	NP_001004441	A5PLL1	AN34B_HUMAN	ankyrin repeat domain 34B	240						cytoplasm|nucleus				pancreas(1)	1		Lung NSC(167;0.0427)|all_lung(232;0.0464)|Ovarian(174;0.113)		OV - Ovarian serous cystadenocarcinoma(54;2.17e-46)|Epithelial(54;5.64e-41)|all cancers(79;3.24e-36)		GGGGAGCTTGGGCCCCTTAGG	0.527		NA											16	48					1.36e-06	2.23e-06	1	0
GPR98	84059	broad.mit.edu	37	5	89930999	89930999	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:89930999C>T	uc003kju.2	+	10	2004	c.1908C>T	c.(1906-1908)ATC>ATT	p.I636I	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	636	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TTGGGGAAATCTGCAATATTT	0.358		NA											22	71					0	0	0	0
GPR98	84059	broad.mit.edu	37	5	89954097	89954097	+	Splice_Site	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:89954097T>A	uc003kju.2	+	21	4848	c.4752_splice	c.e21+2	p.E1584_splice	GPR98_uc003kjt.2_Splice_Site	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor						cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		ATACCAGAGGTAAGTAGTGAG	0.373		NA											18	40					0	0	0	0
MCTP1	79772	broad.mit.edu	37	5	94353071	94353071	+	Missense_Mutation	SNP	C	C	A	rs111625916		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:94353071C>A	uc003kkx.2	-	2	838	c.838G>T	c.(838-840)GGG>TGG	p.G280W	MCTP1_uc003kkv.2_Missense_Mutation_p.G59W|MCTP1_uc003kkw.2_Missense_Mutation_p.G59W|MCTP1_uc003kkz.2_Intron	NM_024717	NP_078993	Q6DN14	MCTP1_HUMAN	multiple C2 domains, transmembrane 1 isoform L	280	C2 1.				calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(2)	2		all_cancers(142;1.68e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0167)|Lung NSC(167;0.0207)|Ovarian(225;0.0218)|Colorectal(57;0.207)		all cancers(79;9.1e-17)		ATGCTCTTACCTCCTCGATCT	0.403		NA											28	71					1.14e-10	2.05e-10	1	0
ELL2	22936	broad.mit.edu	37	5	95234300	95234300	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:95234300T>A	uc003klr.3	-	8	1519	c.1169A>T	c.(1168-1170)CAG>CTG	p.Q390L		NM_012081	NP_036213	O00472	ELL2_HUMAN	elongation factor, RNA polymerase II, 2	390					regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter	transcription elongation factor complex				central_nervous_system(1)	1		all_cancers(142;2.04e-06)|all_epithelial(76;3.1e-09)|all_lung(232;0.00309)|Lung NSC(167;0.00454)|Ovarian(225;0.0165)|Colorectal(57;0.0343)|Breast(839;0.198)		all cancers(79;2.16e-15)		ATTTACAATCTGAGGAGGATG	0.537		NA											38	79					0	0	0	0
FAM174A	345757	broad.mit.edu	37	5	99871504	99871504	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:99871504G>T	uc003knj.1	+	1	390	c.270G>T	c.(268-270)GGG>GGT	p.G90G	uc003kni.2_5'Flank	NM_198507	NP_940909	Q8TBP5	F174A_HUMAN	family with sequence similarity 174, member A	90	Extracellular (Potential).					integral to membrane					0						CTGTGGCCGGGCTTGAGACGG	0.726		NA											7	13					8.13e-05	0.000124651	1	0
SLCO4C1	353189	broad.mit.edu	37	5	101606491	101606491	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:101606491C>T	uc003knm.2	-	3	926	c.639G>A	c.(637-639)AGG>AGA	p.R213R		NM_180991	NP_851322	Q6ZQN7	SO4C1_HUMAN	solute carrier organic anion transporter family,	213	Extracellular (Potential).				cell differentiation|multicellular organismal development|sodium-independent organic anion transport|spermatogenesis	basolateral plasma membrane|integral to membrane	sodium-independent organic anion transmembrane transporter activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)|pancreas(1)	4		all_cancers(142;1.86e-08)|all_epithelial(76;5.24e-12)|Prostate(80;0.00124)|Colorectal(57;0.00332)|Ovarian(225;0.024)|Lung NSC(167;0.0402)|all_lung(232;0.0486)		Epithelial(69;4.07e-14)|COAD - Colon adenocarcinoma(37;0.00986)		TGGTGCTATTCCTTGTTGTTA	0.333		NA											9	35					0	0	0	0
SLCO4C1	353189	broad.mit.edu	37	5	101627047	101627047	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:101627047C>T	uc003knm.2	-	2	906	c.619G>A	c.(619-621)GAC>AAC	p.D207N		NM_180991	NP_851322	Q6ZQN7	SO4C1_HUMAN	solute carrier organic anion transporter family,	207	Extracellular (Potential).				cell differentiation|multicellular organismal development|sodium-independent organic anion transport|spermatogenesis	basolateral plasma membrane|integral to membrane	sodium-independent organic anion transmembrane transporter activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)|pancreas(1)	4		all_cancers(142;1.86e-08)|all_epithelial(76;5.24e-12)|Prostate(80;0.00124)|Colorectal(57;0.00332)|Ovarian(225;0.024)|Lung NSC(167;0.0402)|all_lung(232;0.0486)		Epithelial(69;4.07e-14)|COAD - Colon adenocarcinoma(37;0.00986)		AGAAACTTACCTTCAAAAAGA	0.348		NA											17	45					0	0	0	0
PGGT1B	5229	broad.mit.edu	37	5	114573587	114573587	+	Silent	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:114573587C>G	uc003kqw.3	-	4	468	c.447G>C	c.(445-447)GCG>GCC	p.A149A	PGGT1B_uc003kqx.3_Silent_p.A26A|PGGT1B_uc010jch.2_Silent_p.A149A	NM_005023	NP_005014	P53609	PGTB1_HUMAN	geranylgeranyltransferase type 1 beta	149	PFTB 1.				protein geranylgeranylation	CAAX-protein geranylgeranyltransferase complex	CAAX-protein geranylgeranyltransferase activity				0		all_cancers(142;0.000523)|all_epithelial(76;6.45e-06)|Prostate(80;0.00955)|Ovarian(225;0.0443)|all_lung(232;0.132)|Breast(839;0.195)		Epithelial(69;2.95e-08)|OV - Ovarian serous cystadenocarcinoma(64;4.98e-08)|all cancers(49;3.1e-06)	Pravastatin(DB00175)	CTCTCAAGCCCGCTAAGCAAG	0.388		NA											26	75					0	0	0	0
TMED7-TICAM2	100302736	broad.mit.edu	37	5	114916308	114916308	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:114916308T>C	uc003krd.2	-	4	1652	c.646A>G	c.(646-648)AAG>GAG	p.K216E	TMED7-TICAM2_uc003kre.2_Missense_Mutation_p.K385E|TICAM2_uc003krc.2_Missense_Mutation_p.K216E	NM_021649	NP_067681	Q86XR7	TCAM2_HUMAN	toll-like receptor adaptor molecule 2	216	TIR.				I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	Golgi apparatus|intrinsic to membrane|plasma membrane	protein binding|transmembrane receptor activity				0						TGTTGTGTCTTATACACAGAC	0.378		NA											17	44					0	0	0	0
AQPEP	206338	broad.mit.edu	37	5	115336169	115336169	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:115336169G>T	uc003kro.2	+	8	1719	c.1555G>T	c.(1555-1557)GAG>TAG	p.E519*	AQPEP_uc003krp.2_RNA|AQPEP_uc003krq.2_RNA|AQPEP_uc003krr.2_RNA|AQPEP_uc003krs.2_RNA	NM_173800	NP_776161	Q6Q4G3	AMPQ_HUMAN	laeverin	519	Lumenal (Potential).				proteolysis	integral to membrane	metallopeptidase activity|zinc ion binding				0						TTTCTTGAATGAGCATTTATT	0.378		NA											30	87					9.66e-10	1.72e-09	1	0
FTMT	94033	broad.mit.edu	37	5	121187730	121187730	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:121187730C>T	uc003kss.2	+	1	81	c.72C>T	c.(70-72)TGC>TGT	p.C24C		NM_177478	NP_803431	Q8N4E7	FTMT_HUMAN	ferritin mitochondrial precursor	24					cellular iron ion homeostasis|iron ion transport|positive regulation of cell proliferation|positive regulation of lyase activity|positive regulation of oxidoreductase activity|positive regulation of transferase activity	mitochondrion	ferric iron binding|ferroxidase activity			ovary(1)	1		all_cancers(142;0.0124)|Prostate(80;0.0322)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	Epithelial(69;0.000171)|OV - Ovarian serous cystadenocarcinoma(64;0.000188)|all cancers(49;0.0027)		CGGTGCGCTGCTGCTTCGCGC	0.731		NA											4	34					0	0	0	0
FBN2	2201	broad.mit.edu	37	5	127671152	127671152	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:127671152C>T	uc003kuu.2	-	29	4281	c.3842G>A	c.(3841-3843)TGT>TAT	p.C1281Y	FBN2_uc003kuv.2_Missense_Mutation_p.C1248Y	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	1281	EGF-like 19; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TATACCTGCACACGATCTCCC	0.433		NA											26	98					0	0	0	0
RAD50	10111	broad.mit.edu	37	5	131953939	131953939	+	Silent	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:131953939A>T	uc003kxi.2	+	21	3729	c.3342A>T	c.(3340-3342)ACA>ACT	p.T1114T	RAD50_uc003kxh.2_Silent_p.T975T	NM_005732	NP_005723	Q92878	RAD50_HUMAN	RAD50 homolog isoform 1	1114					DNA duplex unwinding|double-strand break repair via homologous recombination|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|telomere maintenance via telomerase	Mre11 complex|nuclear chromosome, telomeric region|nucleoplasm	ATP binding|DNA binding|nuclease activity|protein binding, bridging|zinc ion binding			lung(2)|ovary(1)|skin(1)	4		all_cancers(142;0.0368)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TGAGGACAACAGAACTTGTGA	0.318		NA						Homologous_recombination					26	57					0	0	0	0
IL13	3596	broad.mit.edu	37	5	131993925	131993925	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:131993925C>A	uc003kxj.1	+	1	61	c.47C>A	c.(46-48)GCG>GAG	p.A16E		NM_002188	NP_002179	P35225	IL13_HUMAN	interleukin 13 precursor	16					cellular component movement|immune response|inflammatory response|signal transduction	extracellular space|soluble fraction	cytokine activity			ovary(1)|skin(1)	2		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GGCCTCATGGCGCTTTTGTTG	0.592		NA									OREG0003464	type=REGULATORY REGION|Gene=IL13|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	18	51					5.04e-11	9.14e-11	1	0
TGFBI	7045	broad.mit.edu	37	5	135394834	135394834	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:135394834G>T	uc003lbf.3	+	13	1895	c.1734G>T	c.(1732-1734)CTG>CTT	p.L578L	TGFBI_uc003lbg.3_Silent_p.L311L|TGFBI_uc003lbh.3_Silent_p.L404L|TGFBI_uc011cyb.1_Silent_p.L404L|TGFBI_uc010jed.2_Silent_p.L311L|TGFBI_uc010jee.2_5'Flank	NM_000358	NP_000349	Q15582	BGH3_HUMAN	transforming growth factor, beta-induced, 68kDa	578	FAS1 4.				angiogenesis|cell adhesion|cell proliferation|negative regulation of cell adhesion|response to stimulus|visual perception	extracellular space|proteinaceous extracellular matrix	integrin binding			breast(3)|ovary(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			ATGAAATCCTGGTTAGCGGAG	0.502		NA											10	18					5.17e-11	9.37e-11	1	0
WNT8A	7478	broad.mit.edu	37	5	137419813	137419813	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:137419813G>C	uc003lcd.1	+	1	40	c.35G>C	c.(34-36)GGC>GCC	p.G12A	BRD8_uc003lcc.1_Intron|WNT8A_uc011cyj.1_5'UTR|WNT8A_uc011cyk.1_5'UTR	NM_058244	NP_490645	Q9H1J5	WNT8A_HUMAN	wingless-type MMTV integration site family,	12					brain segmentation|canonical Wnt receptor signaling pathway involved in neural crest cell differentiation|cell migration involved in gastrulation|dorsal/ventral pattern formation|ectoderm development|endoderm development|eye development|hindbrain development|mesodermal cell fate commitment|negative regulation of Wnt receptor signaling pathway|neural crest cell fate commitment|neural plate pattern specification|notochord development|palate development|polarity specification of anterior/posterior axis|polarity specification of proximal/distal axis|positive regulation of fibroblast growth factor receptor signaling pathway|regulation of transcription involved in anterior/posterior axis specification|response to retinoic acid|somitogenesis|spinal cord anterior/posterior patterning|tail morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled binding|signal transducer activity			ovary(1)|lung(1)|breast(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			GCAGCTCTGGGCATATGCTGT	0.587		NA											13	38					0	0	0	0
PCDHA1	56147	broad.mit.edu	37	5	140167848	140167848	+	Missense_Mutation	SNP	C	C	G	rs149133665		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:140167848C>G	uc003lhb.2	+	1	1973	c.1973C>G	c.(1972-1974)GCG>GGG	p.A658G	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lgz.2_Missense_Mutation_p.A658G	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	658	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTGAGCCGGCGCTGACAGCC	0.667		NA											19	81					0	0	0	0
PCDHA1	56147	broad.mit.edu	37	5	140167951	140167951	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:140167951G>A	uc003lhb.2	+	1	2076	c.2076G>A	c.(2074-2076)GCG>GCA	p.A692A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lgz.2_Silent_p.A692A	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	692	Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGAGGCGGCGCTGGTGGATG	0.662		NA											24	67					0	0	0	0
PCDHA3	56145	broad.mit.edu	37	5	140182402	140182402	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:140182402G>T	uc003lhf.2	+	1	1620	c.1620G>T	c.(1618-1620)GCG>GCT	p.A540A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA2_uc011czy.1_Intron|PCDHA3_uc011czz.1_Silent_p.A540A	NM_018906	NP_061729	Q9Y5H8	PCDA3_HUMAN	protocadherin alpha 3 isoform 1 precursor	540	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(6)|skin(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCGCGATGCGGGCGTGCCGC	0.672		NA											50	131					4.45e-29	9.33e-29	1	0
PCDHA3	56145	broad.mit.edu	37	5	140182502	140182502	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:140182502G>A	uc003lhf.2	+	1	1720	c.1720G>A	c.(1720-1722)GGT>AGT	p.G574S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA2_uc011czy.1_Intron|PCDHA3_uc011czz.1_Missense_Mutation_p.G574S	NM_018906	NP_061729	Q9Y5H8	PCDA3_HUMAN	protocadherin alpha 3 isoform 1 precursor	574	Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(6)|skin(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGTGGCATCGGTGGCGCAGT	0.682		NA											44	86					0	0	0	0
PCDHA5	56143	broad.mit.edu	37	5	140203532	140203532	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:140203532G>T	uc003lhl.2	+	1	2172	c.2172G>T	c.(2170-2172)GCG>GCT	p.A724A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Silent_p.A724A|PCDHA5_uc003lhj.1_Silent_p.A724A	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	724	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(1)|breast(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTGCTCGGCGCAGCCCACCG	0.657		NA											20	63					2.39e-15	4.64e-15	1	0
PCDHA10	56139	broad.mit.edu	37	5	140237321	140237321	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:140237321C>G	uc003lhx.2	+	1	1688	c.1688C>G	c.(1687-1689)GCG>GGG	p.A563G	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc011dad.1_Missense_Mutation_p.A563G	NM_018901	NP_061724	Q9Y5I2	PCDAA_HUMAN	protocadherin alpha 10 isoform 1 precursor	563	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)|breast(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AACGCTCCCGCGCTGCTGGCG	0.687		NA											25	20					0	0	0	0
PCDHA12	56137	broad.mit.edu	37	5	140255363	140255364	+	Nonsense_Mutation	DNP	CA	CA	AG			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:140255363_140255364CA>AG	uc003lic.2	+	1	433_434	c.306_307CA>AG	c.(304-309)TGCAGT>TGAGGT	p.102_103CS>*G	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc011daf.1_Nonsense_Mutation_p.102_103CS>*G	NM_018903	NP_061726	Q9UN75	PCDAC_HUMAN	protocadherin alpha 12 isoform 1 precursor	102_103	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGCGGAGTGCAGTATCCACCT	0.554		NA											73	186					0	0	0	0
PCDHAC2	56134	broad.mit.edu	37	5	140346602	140346602	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:140346602C>A	uc003lii.2	+	1	491	c.251C>A	c.(250-252)GCG>GAG	p.A84E	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Intron|PCDHA13_uc003lif.2_Intron|PCDHAC1_uc003lih.2_Intron|PCDHAC2_uc011dag.1_Missense_Mutation_p.A84E	NM_018899	NP_061722	Q9Y5I4	PCDC2_HUMAN	protocadherin alpha subfamily C, 2 isoform 1	84	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CATCTGGGTGCGCCCAGTCCG	0.697		NA											11	28					4.38e-07	7.3e-07	1	0
PCDHB1	29930	broad.mit.edu	37	5	140433332	140433332	+	Silent	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:140433332A>T	uc003lik.1	+	1	2354	c.2277A>T	c.(2275-2277)TCA>TCT	p.S759S		NM_013340	NP_037472	Q9Y5F3	PCDB1_HUMAN	protocadherin beta 1 precursor	759	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AAATGTGTTCAGCCACTGGCA	0.443		NA											6	92					0	0	0	0
PCDHB2	56133	broad.mit.edu	37	5	140474516	140474516	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:140474516G>T	uc003lil.2	+	1	280	c.142G>T	c.(142-144)GCC>TCC	p.A48S	PCDHB2_uc003lim.1_Intron	NM_018936	NP_061759	Q9Y5E7	PCDB2_HUMAN	protocadherin beta 2 precursor	48	Extracellular (Potential).|Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(3)|upper_aerodigestive_tract(2)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTCCTTTGTGGCCAATTTGTT	0.498		NA											13	49					1.05e-09	1.87e-09	1	0
PCDHB3	56132	broad.mit.edu	37	5	140481907	140481907	+	Silent	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:140481907G>C	uc003lio.2	+	1	1674	c.1674G>C	c.(1672-1674)TCG>TCC	p.S558S	uc003lin.2_5'Flank	NM_018937	NP_061760	Q9Y5E6	PCDB3_HUMAN	protocadherin beta 3 precursor	558	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACGACAACTCGCCCTTCGTGC	0.711		NA											30	76					0	0	0	0
PCDHB16	57717	broad.mit.edu	37	5	140562178	140562178	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:140562178T>C	uc003liv.2	+	1	1199	c.44T>C	c.(43-45)CTT>CCT	p.L15P	PCDHB16_uc010jfw.1_Intron	NM_020957	NP_066008	Q9NRJ7	PCDBG_HUMAN	protocadherin beta 16 precursor	15					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGGCAAGTCCTTGTTTTCTTT	0.473		NA											39	101					0	0	0	0
PCDHB14	56122	broad.mit.edu	37	5	140604444	140604444	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:140604444A>G	uc003ljb.2	+	1	1367	c.1367A>G	c.(1366-1368)TAC>TGC	p.Y456C	PCDHB14_uc011dal.1_Missense_Mutation_p.Y303C	NM_018934	NP_061757	Q9Y5E9	PCDBE_HUMAN	protocadherin beta 14 precursor	456	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CAAACCTCCTACACCCTGTTC	0.592		NA											58	184					0	0	0	0
PCDHB15	56121	broad.mit.edu	37	5	140625859	140625859	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:140625859A>T	uc003lje.2	+	1	713	c.713A>T	c.(712-714)AAT>ATT	p.N238I		NM_018935	NP_061758	Q9Y5E8	PCDBF_HUMAN	protocadherin beta 15 precursor	238	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|breast(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCCAATGACAATGCCCCGGAG	0.577		NA											8	23					0	0	0	0
ARAP3	64411	broad.mit.edu	37	5	141059771	141059771	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:141059771C>A	uc003llm.2	-	2	361	c.283G>T	c.(283-285)GTG>TTG	p.V95L	ARAP3_uc003lln.2_Missense_Mutation_p.V17L|ARAP3_uc003llo.1_Missense_Mutation_p.V95L	NM_022481	NP_071926	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	95	Pro-rich.				cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			breast(5)|ovary(1)|large_intestine(1)	7						GGCTTCGGCACGGGCTTAGGG	0.657		NA											22	73					7.42e-09	1.28e-08	1	0
SPRY4	81848	broad.mit.edu	37	5	141693814	141693814	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:141693814C>A	uc003lml.2	-	2	1119	c.860G>T	c.(859-861)AGC>ATC	p.S287I	SPRY4_uc010jgi.1_Missense_Mutation_p.S310I	NM_001127496	NP_001120968	Q9C004	SPY4_HUMAN	sprouty homolog 4 isoform 2	287					multicellular organismal development	cytoplasm|ruffle membrane	protein binding			ovary(1)|lung(1)	2		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCATCCCCGCTGGCTGCTTT	0.617		NA							Testicular_Cancer_Familial_Clustering_of				12	33					0.00136819	0.00201271	1	0
POU4F3	5459	broad.mit.edu	37	5	145719828	145719828	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:145719828T>A	uc003loa.2	+	2	927	c.838T>A	c.(838-840)TCC>ACC	p.S280T		NM_002700	NP_002691	Q15319	PO4F3_HUMAN	POU class 4 homeobox 3	280	Homeobox.				sensory perception of sound|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CAAACGCACGTCCATCGCGGC	0.612		NA											21	45					0	0	0	0
PPP2R2B	5521	broad.mit.edu	37	5	145969694	145969694	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:145969694T>A	uc003loe.2	-	9	1673	c.1148A>T	c.(1147-1149)AAG>ATG	p.K383M	PPP2R2B_uc010jgm.2_Missense_Mutation_p.K372M|PPP2R2B_uc003log.3_Missense_Mutation_p.K383M|PPP2R2B_uc003lof.3_Missense_Mutation_p.K383M|PPP2R2B_uc003loi.3_Missense_Mutation_p.K386M|PPP2R2B_uc003loh.3_Missense_Mutation_p.K383M|PPP2R2B_uc003loj.3_Missense_Mutation_p.K363M|PPP2R2B_uc003lok.3_Missense_Mutation_p.K372M|PPP2R2B_uc011dbu.1_Missense_Mutation_p.K389M|PPP2R2B_uc011dbv.1_Missense_Mutation_p.K441M	NM_004576	NP_004567	Q00005	2ABB_HUMAN	beta isoform of regulatory subunit B55, protein	383					apoptosis|signal transduction	cytoskeleton|mitochondrial outer membrane|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			ovary(1)|prostate(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGCCCGGGGCTTGCTGTTTTC	0.507		NA											38	82					0	0	0	0
SH3TC2	79628	broad.mit.edu	37	5	148407063	148407063	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:148407063C>A	uc003lpu.2	-	11	2384	c.2232G>T	c.(2230-2232)CTG>CTT	p.L744L	SH3TC2_uc003lpp.1_RNA|SH3TC2_uc010jgw.2_Silent_p.L388L|SH3TC2_uc003lps.2_RNA|SH3TC2_uc003lpt.2_Silent_p.L291L|SH3TC2_uc010jgx.2_Silent_p.L737L|SH3TC2_uc003lpv.1_Silent_p.L291L|SH3TC2_uc011dbz.1_Silent_p.L629L	NM_024577	NP_078853	Q8TF17	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeats 2	744							binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACAGGCAGCCAGGGCCTGTC	0.592		NA											21	40					3.52e-12	6.47e-12	1	0
CAMK2A	815	broad.mit.edu	37	5	149636159	149636159	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:149636159C>A	uc003lru.2	-	6	603	c.388G>T	c.(388-390)GGG>TGG	p.G130W	CAMK2A_uc003lrt.2_Missense_Mutation_p.G130W|CAMK2A_uc010jhe.2_Missense_Mutation_p.G110W|CAMK2A_uc010jhf.1_Missense_Mutation_p.G2W	NM_171825	NP_741960	Q9UQM7	KCC2A_HUMAN	calcium/calmodulin-dependent protein kinase II	130	Protein kinase.				interferon-gamma-mediated signaling pathway|positive regulation of NF-kappaB transcription factor activity|synaptic transmission	cell junction|cytosol|endocytic vesicle membrane|nucleoplasm|presynaptic membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			large_intestine(1)	1		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TGCACCACCCCCATCTGGTGG	0.637		NA											6	30					3.6e-05	5.62e-05	1	0
ARSI	340075	broad.mit.edu	37	5	149678016	149678016	+	Silent	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:149678016A>G	uc003lrv.2	-	2	1060	c.471T>C	c.(469-471)TGT>TGC	p.C157C		NM_001012301	NP_001012301	Q5FYB1	ARSI_HUMAN	arylsulfatase family, member I precursor	157						endoplasmic reticulum|extracellular region	arylsulfatase activity|metal ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGGTGGGCAGACACTCCTTCC	0.607		NA											19	38					0	0	0	0
KIF4B	285643	broad.mit.edu	37	5	154394597	154394597	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:154394597A>T	uc010jih.1	+	1	1338	c.1178A>T	c.(1177-1179)CAG>CTG	p.Q393L		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	393	Potential.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			GAGAAGAATCAGTCCCTGGTA	0.468		NA											33	100					0	0	0	0
HAVCR1	26762	broad.mit.edu	37	5	156479381	156479381	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:156479381G>T	uc010jij.1	-	4	849	c.664C>A	c.(664-666)CAT>AAT	p.H222N	HAVCR1_uc011ddl.1_Missense_Mutation_p.H53N|HAVCR1_uc003lwi.2_Missense_Mutation_p.H222N|HAVCR1_uc011ddm.1_Missense_Mutation_p.H222N	NM_001099414	NP_001092884	Q96D42	HAVR1_HUMAN	hepatitis A virus cellular receptor 1	217	Extracellular (Potential).				interspecies interaction between organisms	integral to membrane	receptor activity			ovary(1)|skin(1)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CCTGGTTCATGGTTCTGCCTG	0.488		NA											50	138					4.19e-23	8.66e-23	1	0
NIPAL4	348938	broad.mit.edu	37	5	156899365	156899365	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:156899365G>A	uc003lwx.3	+	6	914	c.798G>A	c.(796-798)CTG>CTA	p.L266L	ADAM19_uc003lww.1_Intron|NIPAL4_uc011ddq.1_Silent_p.L247L	NM_001099287	NP_001092757	Q0D2K0	NIPA4_HUMAN	ichthyin protein	266	Helical; (Potential).					integral to membrane	receptor activity				0						CTGTGCTTCTGCTGGTGTCAT	0.507		NA									OREG0016979	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	73	150					0	0	0	0
ADAM19	8728	broad.mit.edu	37	5	156929850	156929850	+	Nonsense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:156929850A>T	uc003lwz.2	-	12	1333	c.1269T>A	c.(1267-1269)TAT>TAA	p.Y423*	ADAM19_uc003lww.1_Nonsense_Mutation_p.Y156*|ADAM19_uc003lwy.2_Nonsense_Mutation_p.Y22*|ADAM19_uc011ddr.1_Nonsense_Mutation_p.Y354*	NM_033274	NP_150377	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19 preproprotein	423	Disintegrin.|Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			ovary(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CATCTTCCAGATACCCGTTCC	0.527		NA											44	107					0	0	0	0
LSM11	134353	broad.mit.edu	37	5	157181901	157181901	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:157181901G>T	uc003lxe.1	+	4	716	c.712G>T	c.(712-714)GAA>TAA	p.E238*	LSM11_uc003lxf.1_5'Flank	NM_173491	NP_775762	P83369	LSM11_HUMAN	LSM11, U7 small nuclear RNA associated	238					histone mRNA 3'-end processing|S phase of mitotic cell cycle|termination of RNA polymerase II transcription	histone pre-mRNA 3'end processing complex|nucleoplasm|U7 snRNP	protein binding|U7 snRNA binding				0	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CTCCAAGAAGGAAGCAGATTC	0.423		NA											22	39					3.1e-05	4.88e-05	1	0
IL12B	3593	broad.mit.edu	37	5	158753716	158753716	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:158753716T>G	uc003lxr.1	-	2	117	c.75A>C	c.(73-75)GAA>GAC	p.E25D		NM_002187	NP_002178	P29460	IL12B_HUMAN	interleukin 12B precursor	25	Ig-like C2-type.				cell cycle arrest|cell migration|defense response to Gram-negative bacterium|interferon-gamma biosynthetic process|natural killer cell activation|negative regulation of interleukin-10 production|negative regulation of interleukin-17 production|negative regulation of smooth muscle cell proliferation|positive regulation of activated T cell proliferation|positive regulation of activation of JAK2 kinase activity|positive regulation of cell adhesion|positive regulation of defense response to virus by host|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-17 production|positive regulation of memory T cell differentiation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|positive regulation of natural killer cell proliferation|positive regulation of NF-kappaB import into nucleus|positive regulation of NK T cell activation|positive regulation of NK T cell proliferation|positive regulation of osteoclast differentiation|positive regulation of smooth muscle cell apoptosis|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat4 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|regulation of tyrosine phosphorylation of Stat1 protein|response to UV-B|sexual reproduction|T-helper 1 type immune response|T-helper cell differentiation	interleukin-12 complex|interleukin-23 complex|membrane	cytokine activity|cytokine receptor activity|interleukin-12 receptor binding|protein heterodimerization activity				0	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CTTTCTTCAGTTCCCATATGG	0.438		NA											33	77					0	0	0	0
ATP10B	23120	broad.mit.edu	37	5	160071164	160071164	+	Silent	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:160071164A>G	uc003lym.1	-	9	1696	c.849T>C	c.(847-849)GTT>GTC	p.V283V	ATP10B_uc003lyp.2_Silent_p.V283V|ATP10B_uc011deg.1_Silent_p.V327V|ATP10B_uc003lyo.2_Silent_p.V255V	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	283	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TGACAATGCCAACAGCCATCT	0.493		NA											15	63					0	0	0	0
DOCK2	1794	broad.mit.edu	37	5	169188524	169188524	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:169188524C>A	uc003maf.2	+	25	2529	c.2449C>A	c.(2449-2451)CAA>AAA	p.Q817K	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Missense_Mutation_p.Q309K	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	817					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TGCCCTCAGCCAACTCCTGTA	0.483		NA											38	117					5.59e-11	1.01e-10	1	0
DOCK2	1794	broad.mit.edu	37	5	169454881	169454881	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:169454881C>T	uc003maf.2	+	34	3476	c.3396C>T	c.(3394-3396)ATC>ATT	p.I1132I	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Silent_p.I624I	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1132	DHR-2.|Interaction with CRKL.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AAAACGAAATCATCCTGAAGC	0.418		NA											26	63					0	0	0	0
KCNIP1	30820	broad.mit.edu	37	5	170147332	170147332	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:170147332C>A	uc003mas.2	+	4	756	c.227C>A	c.(226-228)CCC>CAC	p.P76H	KCNIP1_uc003map.2_Missense_Mutation_p.P74H|KCNIP1_uc003mat.2_Missense_Mutation_p.P65H|KCNIP1_uc010jjp.2_Missense_Mutation_p.P37H|KCNIP1_uc010jjq.2_Missense_Mutation_p.P65H	NM_001034837	NP_001030009	Q9NZI2	KCIP1_HUMAN	Kv channel interacting protein 1 isoform 1	76	EF-hand 1; degenerate.				detection of calcium ion|signal transduction|synaptic transmission	plasma membrane	potassium channel activity|voltage-gated ion channel activity			skin(2)	2	Renal(175;0.000159)|Lung NSC(126;0.0191)|all_lung(126;0.0297)	Medulloblastoma(196;0.0109)|all_neural(177;0.0177)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CAGGAGTGCCCCAGTGGTGTG	0.547		NA											9	30					2.18e-05	3.43e-05	1	0
STK10	6793	broad.mit.edu	37	5	171523476	171523476	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:171523476T>A	uc003mbo.1	-	8	1259	c.959A>T	c.(958-960)GAC>GTC	p.D320V		NM_005990	NP_005981	O94804	STK10_HUMAN	serine/threonine kinase 10	320							ATP binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|testis(1)|breast(1)|pancreas(1)	8	Renal(175;0.000159)|Lung NSC(126;0.0056)|all_lung(126;0.0094)	Medulloblastoma(196;0.00868)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			ATCCCGGCCGTCTTCGATCTC	0.642		NA											32	81					0	0	0	0
EIF4E1B	253314	broad.mit.edu	37	5	176072481	176072481	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:176072481G>A	uc010jkf.1	+	8	1162	c.578G>A	c.(577-579)AGG>AAG	p.R193K	TSPAN17_uc003mes.3_5'Flank|TSPAN17_uc003met.2_5'Flank|TSPAN17_uc003meu.2_5'Flank|TSPAN17_uc003mev.2_5'Flank|TSPAN17_uc003mew.2_5'Flank	NM_001099408	NP_001092878	A6NMX2	I4E1B_HUMAN	eukaryotic translation initiation factor 4E	193					regulation of translation	cytoplasm|mRNA cap binding complex	translation initiation factor activity				0	all_cancers(89;0.00185)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.00498)|all_neural(177;0.0212)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GTGTGGACGAGGGAGGCGGAA	0.622		NA											13	29					0	0	0	0
NSD1	64324	broad.mit.edu	37	5	176637567	176637567	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:176637567A>T	uc003mfr.3	+	5	2305	c.2167A>T	c.(2167-2169)ACC>TCC	p.T723S	NSD1_uc003mft.3_Missense_Mutation_p.T454S|NSD1_uc003mfs.1_Missense_Mutation_p.T620S|NSD1_uc011dfx.1_Missense_Mutation_p.T371S	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	723					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		AGAGCCTGGAACCGAGACGTC	0.428		NA	T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			26	58					0	0	0	0
NSD1	64324	broad.mit.edu	37	5	176709538	176709538	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:176709538C>T	uc003mfr.3	+	19	6103	c.5965C>T	c.(5965-5967)CAA>TAA	p.Q1989*	NSD1_uc003mft.3_Nonsense_Mutation_p.Q1720*|NSD1_uc011dfx.1_Nonsense_Mutation_p.Q1637*	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1989	SET.			RYAQEH -> KHAHEN (in Ref. 3; AAK92049).	negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		TCGCTATGCTCAAGAACATGA	0.368		NA	T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			24	95					0	0	0	0
ZNF354C	30832	broad.mit.edu	37	5	178503532	178503532	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:178503532G>T	uc003mju.2	+	3	229	c.114G>T	c.(112-114)CGG>CGT	p.R38R		NM_014594	NP_055409	Q86Y25	Z354C_HUMAN	zinc finger protein 354C	38	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_cancers(89;0.00065)|all_epithelial(37;0.000153)|Renal(175;0.000159)|Lung NSC(126;0.00175)|all_lung(126;0.00309)	all_cancers(40;0.19)|all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.247)		CCTTGTACCGGGAGGTGATGC	0.527		NA											24	82					6.36e-07	1.05e-06	1	0
BTNL3	10917	broad.mit.edu	37	5	180424227	180424227	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:180424227C>G	uc003mmr.2	+	3	540	c.412C>G	c.(412-414)CCT>GCT	p.P138A		NM_197975	NP_932079	Q6UXE8	BTNL3_HUMAN	butyrophilin-like 3 precursor	138	Ig-like V-type.|Extracellular (Potential).				lipid metabolic process	integral to membrane					0	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.00336)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)|all_lung(500;0.248)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000272)			GGGCTCACTTCCTCTCATTTC	0.498		NA											39	128					0	0	0	0
JARID2	3720	broad.mit.edu	37	6	15452388	15452388	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:15452388A>C	uc003nbj.2	+	4	719	c.475A>C	c.(475-477)ACC>CCC	p.T159P	JARID2_uc011diu.1_Intron|JARID2_uc011div.1_5'UTR|JARID2_uc011diw.1_Missense_Mutation_p.T121P	NM_004973	NP_004964	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2 protein	159					central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			ovary(2)|lung(1)|pancreas(1)	4	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				AGATTTTCTTACCTTTCTCTG	0.468		NA											26	85					0	0	0	0
ALDH5A1	7915	broad.mit.edu	37	6	24533787	24533787	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:24533787G>A	uc003neg.2	+	10	1483	c.1455G>A	c.(1453-1455)CTG>CTA	p.L485L	ALDH5A1_uc003nef.2_Silent_p.L498L	NM_001080	NP_001071	P51649	SSDH_HUMAN	aldehyde dehydrogenase 5A1 isoform 2 precursor	485					acetate metabolic process|central nervous system development|galactosylceramide metabolic process|gamma-aminobutyric acid catabolic process|glucose metabolic process|glutamate metabolic process|glutamine metabolic process|glutathione metabolic process|glycerophospholipid metabolic process|neurotransmitter catabolic process|neurotransmitter secretion|protein homotetramerization|respiratory electron transport chain|short-chain fatty acid metabolic process|succinate metabolic process	mitochondrial matrix|soluble fraction	succinate-semialdehyde dehydrogenase activity				0					Chlormerodrin(DB00534)|NADH(DB00157)|Succinic acid(DB00139)	CAGAGCAGCTGGAAGTGGGCA	0.493		NA											78	71					0	0	0	0
NKAPL	222698	broad.mit.edu	37	6	28228212	28228212	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:28228212C>T	uc003nkt.2	+	1	1115	c.1063C>T	c.(1063-1065)CGT>TGT	p.R355C	ZKSCAN4_uc011dlb.1_5'Flank	NM_001007531	NP_001007532	Q5M9Q1	NKAPL_HUMAN	NFKB activating protein-like	355										upper_aerodigestive_tract(1)|ovary(1)	2						TGTACGACTGCGTAAGGAGAA	0.443		NA											27	174					0	0	0	0
OR2J3	442186	broad.mit.edu	37	6	29080330	29080330	+	Nonsense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:29080330T>A	uc011dll.1	+	1	663	c.663T>A	c.(661-663)TAT>TAA	p.Y221*		NM_001005216	NP_001005216	O76001	OR2J3_HUMAN	olfactory receptor, family 2, subfamily J,	221	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TCACTTCTTATGGTGCCATCG	0.448		NA											16	137					0	0	0	0
DDR1	780	broad.mit.edu	37	6	30860151	30860151	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:30860151A>G	uc003nrr.2	+	9	1190	c.931A>G	c.(931-933)ATG>GTG	p.M311V	DDR1_uc010jse.2_Missense_Mutation_p.M311V|DDR1_uc003nrq.2_Missense_Mutation_p.M311V|DDR1_uc003nrs.2_Missense_Mutation_p.M311V|DDR1_uc003nrt.2_Missense_Mutation_p.M311V|DDR1_uc011dms.1_Missense_Mutation_p.M329V|DDR1_uc003nru.2_Missense_Mutation_p.M311V|DDR1_uc003nrv.2_Missense_Mutation_p.M311V|DDR1_uc003nrw.1_Missense_Mutation_p.M110V|DDR1_uc003nry.1_5'Flank|DDR1_uc003nrx.1_5'Flank	NM_013993	NP_054699	Q08345	DDR1_HUMAN	discoidin domain receptor family, member 1	311	Extracellular (Potential).				cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane	ATP binding|protein binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(4)|central_nervous_system(3)|large_intestine(1)|ovary(1)	9					Imatinib(DB00619)	TGGCCCTGCCATGGCCTGGGA	0.697		NA											31	36					0	0	0	0
PPT2	9374	broad.mit.edu	37	6	32122555	32122555	+	Splice_Site	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:32122555G>T	uc003nzx.2	+	2	751	c.183_splice	c.e2+1	p.E61_splice	PRRT1_uc003nzs.2_5'Flank|PRRT1_uc003nzt.2_5'Flank|PRRT1_uc003nzu.2_5'Flank|uc003nzv.3_5'Flank|PPT2_uc003nzw.2_Splice_Site_p.E67_splice|PPT2_uc011dpi.1_Splice_Site|PPT2_uc003nzy.1_Splice_Site|PPT2_uc003nzz.2_Splice_Site_p.E61_splice|PPT2_uc003oaa.2_Splice_Site_p.E61_splice|PPT2_uc010jtu.1_Splice_Site_p.E61_splice	NM_005155	NP_005146	Q9UMR5	PPT2_HUMAN	palmitoyl-protein thioesterase 2 isoform a						protein modification process	lysosome	palmitoyl-(protein) hydrolase activity				0						CATCAATGAGGTCTGGCAGGG	0.647		NA											32	39					1.89e-17	3.75e-17	1	0
NOTCH4	4855	broad.mit.edu	37	6	32169141	32169141	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:32169141C>T	uc003obb.2	-	22	4031	c.3892G>A	c.(3892-3894)GCC>ACC	p.A1298T	NOTCH4_uc003oba.2_5'UTR|NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	1298	Extracellular (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						ACCAGCAGGGCCAGGGAGGGC	0.637		NA											45	25					0	0	0	0
COL11A2	1302	broad.mit.edu	37	6	33146101	33146101	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:33146101C>A	uc003ocx.1	-	20	2030	c.1802G>T	c.(1801-1803)GGG>GTG	p.G601V	COL11A2_uc010jul.1_5'Flank|COL11A2_uc003ocy.1_Missense_Mutation_p.G515V|COL11A2_uc003ocz.1_Missense_Mutation_p.G494V	NM_080680	NP_542411	P13942	COBA2_HUMAN	collagen, type XI, alpha 2 isoform 1	601	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			ovary(3)|skin(2)	5						TCCAGGCAGCCCTCGAGGCCC	0.617		NA											18	141					4.76e-15	9.21e-15	1	0
RGL2	5863	broad.mit.edu	37	6	33262943	33262943	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:33262943C>T	uc003odv.2	-	9	1303	c.1170G>A	c.(1168-1170)GAG>GAA	p.E390E	RGL2_uc003odu.2_5'UTR|RGL2_uc010jur.2_5'UTR|RGL2_uc003odw.2_Silent_p.E308E|RGL2_uc011drb.1_Silent_p.E308E	NM_004761	NP_004752	O15211	RGL2_HUMAN	ral guanine nucleotide dissociation	390	Ras-GEF.				Ras protein signal transduction|regulation of small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity			skin(3)|lung(1)|breast(1)|pancreas(1)	6						AATTATCCTCCTCGGAGAAAA	0.577		NA											4	23					0	0	0	0
CPNE5	57699	broad.mit.edu	37	6	36766231	36766231	+	Splice_Site	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:36766231C>A	uc003omr.1	-	5	394	c.327_splice	c.e5+1	p.H109_splice	CPNE5_uc003oms.1_Splice_Site_p.H71_splice	NM_020939	NP_065990	Q9HCH3	CPNE5_HUMAN	copine V											skin(1)	1						GCAGAACTCACGTGTTTGGAT	0.512		NA											28	28					8.58e-18	1.71e-17	1	0
DNAH8	1769	broad.mit.edu	37	6	38885916	38885916	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:38885916G>A	uc003ooe.1	+	68	10473	c.9873G>A	c.(9871-9873)AAG>AAA	p.K3291K	uc003oof.1_Intron	NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						TGCCTCTGAAGGTAAAAGTTT	0.373		NA											13	48					0	0	0	0
NCR2	9436	broad.mit.edu	37	6	41304148	41304148	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:41304148T>G	uc003oqh.2	+	2	463	c.376T>G	c.(376-378)TAT>GAT	p.Y126D	NCR2_uc003oqi.2_Missense_Mutation_p.Y126D|NCR2_uc003oqj.2_Missense_Mutation_p.Y126D	NM_004828	NP_004819	O95944	NCTR2_HUMAN	natural cytotoxicity triggering receptor 2	126	Extracellular (Potential).				cellular defense response	integral to plasma membrane	transmembrane receptor activity			ovary(1)	1	Ovarian(28;0.0327)|Colorectal(47;0.196)					CGTCAGATTCTATCTGGTGGT	0.532		NA											59	31					0	0	0	0
TRERF1	55809	broad.mit.edu	37	6	42236484	42236484	+	Missense_Mutation	SNP	C	C	A	rs147382652		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:42236484C>A	uc003osd.2	-	5	1408	c.845G>T	c.(844-846)CGT>CTT	p.R282L	TRERF1_uc011duq.1_Missense_Mutation_p.R282L|TRERF1_uc003osb.2_Missense_Mutation_p.R121L|TRERF1_uc003osc.2_Missense_Mutation_p.R121L|TRERF1_uc003ose.2_Missense_Mutation_p.R282L	NM_033502	NP_277037	Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	282	Gln-rich.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			ovary(3)|pancreas(1)|skin(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CATGGAGATACGCTGTTGCCC	0.488		NA											91	69					3.78e-48	8.06e-48	1	0
PTCRA	171558	broad.mit.edu	37	6	42890971	42890971	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:42890971T>G	uc003osx.2	+	2	346	c.265T>G	c.(265-267)TTG>GTG	p.L89V	PTCRA_uc011duz.1_Silent_p.T99T|PTCRA_uc010jxx.1_Silent_p.T49T|PTCRA_uc010jxy.2_Missense_Mutation_p.L64V|PTCRA_uc010jxz.2_Intron	NM_138296	NP_612153	Q6ISU1	PTCRA_HUMAN	pre T-cell antigen receptor alpha precursor	89	Extracellular (Potential).					integral to membrane	receptor activity			ovary(2)	2	Colorectal(47;0.196)		all cancers(41;0.000731)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|OV - Ovarian serous cystadenocarcinoma(102;0.0218)|Kidney(15;0.0388)			CTGGACCAACTTGGCCCATCT	0.622		NA											29	156					0	0	0	0
CENPQ	55166	broad.mit.edu	37	6	49456174	49456174	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:49456174G>T	uc003ozh.1	+	7	676	c.587G>T	c.(586-588)AGA>ATA	p.R196I		NM_018132	NP_060602	Q7L2Z9	CENPQ_HUMAN	centromere protein Q	196	Potential.				CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	chromosome, centromeric region|cytosol|nucleoplasm				ovary(2)	2	Lung NSC(77;0.0128)					GAAGAGGAGAGAGTAAAACAG	0.313		NA											36	35					3.93e-24	8.17e-24	1	0
RHAG	6005	broad.mit.edu	37	6	49578777	49578777	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:49578777G>T	uc003ozk.3	-	7	1089	c.1027C>A	c.(1027-1029)CTT>ATT	p.L343I	RHAG_uc010jzl.2_Missense_Mutation_p.L343I|RHAG_uc010jzm.2_Intron	NM_000324	NP_000315	Q02094	RHAG_HUMAN	Rh-associated glycoprotein	343	Helical; (Potential).				carbon dioxide transport|cellular ion homeostasis	integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			breast(1)|skin(1)	2	Lung NSC(77;0.0255)					ATGCCTGCAAGGCCTCCCACT	0.473		NA											50	48					2.9e-28	6.07e-28	1	0
CRISP2	7180	broad.mit.edu	37	6	49665662	49665662	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:49665662C>A	uc003ozq.2	-	8	682	c.426G>T	c.(424-426)TGG>TGT	p.W142C	CRISP2_uc003ozl.2_Missense_Mutation_p.W142C|CRISP2_uc003ozn.2_Missense_Mutation_p.W142C|CRISP2_uc003ozr.2_Missense_Mutation_p.W142C|CRISP2_uc003ozo.2_Missense_Mutation_p.W142C|CRISP2_uc003ozm.2_Missense_Mutation_p.W142C|CRISP2_uc003ozp.2_Missense_Mutation_p.W142C	NM_001142408	NP_001135880	P16562	CRIS2_HUMAN	cysteine-rich secretory protein 2 precursor	142						extracellular space				skin(1)	1	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			AAGTCGAGTACCAAACAAGCT	0.313		NA											20	128					8.34e-07	1.37e-06	1	0
PKHD1	5314	broad.mit.edu	37	6	51750673	51750673	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:51750673C>A	uc003pah.1	-	45	7483	c.7207G>T	c.(7207-7209)GGT>TGT	p.G2403C	PKHD1_uc010jzn.1_Missense_Mutation_p.G386C|PKHD1_uc003pai.2_Missense_Mutation_p.G2403C	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	2403	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					ACCTGGGCACCACCTGCACTT	0.353		NA											14	46					1.36e-06	2.23e-06	1	0
PKHD1	5314	broad.mit.edu	37	6	51947209	51947209	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:51947209C>T	uc003pah.1	-	4	538	c.262G>A	c.(262-264)GTG>ATG	p.V88M	PKHD1_uc003pai.2_Missense_Mutation_p.V88M	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	88	Extracellular (Potential).|IPT/TIG 1; atypical.				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					CATGTCACCACAGGCAAATCC	0.488		NA											173	135					0	0	0	0
TINAG	27283	broad.mit.edu	37	6	54173485	54173485	+	Missense_Mutation	SNP	G	G	T	rs147898099		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:54173485G>T	uc003pcj.2	+	1	283	c.137G>T	c.(136-138)CGA>CTA	p.R46L	TINAG_uc003pci.2_Missense_Mutation_p.R46L|TINAG_uc010jzt.2_RNA	NM_014464	NP_055279	Q9UJW2	TINAG_HUMAN	tubulointerstitial nephritis antigen	46					cell adhesion|immune response|Malpighian tubule morphogenesis|proteolysis	basement membrane	cysteine-type endopeptidase activity|nucleotide binding|polysaccharide binding|scavenger receptor activity			ovary(3)|central_nervous_system(1)	4	Lung NSC(77;0.0518)		LUSC - Lung squamous cell carcinoma(124;0.246)			CAAGGTACTCGATTCAAAAGA	0.428		NA											33	165					1.46e-13	2.75e-13	1	0
TINAG	27283	broad.mit.edu	37	6	54214631	54214631	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:54214631C>T	uc003pcj.2	+	7	1163	c.1017C>T	c.(1015-1017)CCC>CCT	p.P339P	TINAG_uc010jzt.2_RNA	NM_014464	NP_055279	Q9UJW2	TINAG_HUMAN	tubulointerstitial nephritis antigen	339					cell adhesion|immune response|Malpighian tubule morphogenesis|proteolysis	basement membrane	cysteine-type endopeptidase activity|nucleotide binding|polysaccharide binding|scavenger receptor activity			ovary(3)|central_nervous_system(1)	4	Lung NSC(77;0.0518)		LUSC - Lung squamous cell carcinoma(124;0.246)			AGCCATGTCCCAACAACGTAG	0.443		NA											96	60					0	0	0	0
ZNF451	26036	broad.mit.edu	37	6	57006110	57006110	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:57006110A>T	uc003pdm.1	+	8	937	c.713A>T	c.(712-714)GAT>GTT	p.D238V	ZNF451_uc003pdl.2_Missense_Mutation_p.D238V|ZNF451_uc003pdn.1_Missense_Mutation_p.D238V|uc003pdq.1_Intron|ZNF451_uc003pdk.1_Missense_Mutation_p.D238V	NM_001031623	NP_001026794	Q9Y4E5	ZN451_HUMAN	zinc finger protein 451 isoform 1	238					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|pancreas(1)	2	Lung NSC(77;0.145)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			GAAGCCACAGATGATGGACAT	0.323		NA											6	42					0	0	0	0
KHDRBS2	202559	broad.mit.edu	37	6	62390894	62390894	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:62390894T>C	uc003peg.2	-	9	1271	c.1024A>G	c.(1024-1026)AGG>GGG	p.R342G		NM_152688	NP_689901	Q5VWX1	KHDR2_HUMAN	KH domain-containing, RNA-binding, signal	342					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			skin(7)|ovary(3)|liver(1)	11				BRCA - Breast invasive adenocarcinoma(397;0.149)		GGGTGTTCCCTGTATCCCCCT	0.498		NA											17	32					0	0	0	0
COL19A1	1310	broad.mit.edu	37	6	70847590	70847590	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:70847590T>A	uc003pfc.1	+	19	1514	c.1397T>A	c.(1396-1398)CTA>CAA	p.L466Q	COL19A1_uc010kam.1_Missense_Mutation_p.L362Q	NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	466	Triple-helical region 3 (COL3).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						GAAACTGGACTACCAGGATTT	0.408		NA											36	104					0	0	0	0
COL19A1	1310	broad.mit.edu	37	6	70859624	70859624	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:70859624G>T	uc003pfc.1	+	28	2039	c.1922G>T	c.(1921-1923)GGT>GTT	p.G641V	COL19A1_uc010kam.1_Missense_Mutation_p.G537V	NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	641	Triple-helical region 3 (COL3).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						GGAGAGCCAGGTATTCAGGTA	0.383		NA											13	34					0.00244969	0.00356876	1	0
COL12A1	1303	broad.mit.edu	37	6	75893061	75893061	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:75893061C>T	uc003phs.2	-	10	1762	c.1596G>A	c.(1594-1596)GTG>GTA	p.V532V	COL12A1_uc003pht.2_Intron|COL12A1_uc003phu.1_Silent_p.V190V	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	532	VWFA 2.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						CCTTGCTAGGCACAAATATTT	0.393		NA											41	105					0	0	0	0
SNAP91	9892	broad.mit.edu	37	6	84350842	84350842	+	Silent	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:84350842T>C	uc011dze.1	-	8	1055	c.738A>G	c.(736-738)CGA>CGG	p.R246R	SNAP91_uc003pkb.2_Silent_p.R211R|SNAP91_uc003pkc.2_Silent_p.R246R|SNAP91_uc003pkd.2_Silent_p.R246R|SNAP91_uc003pka.2_Silent_p.R246R|SNAP91_uc011dzf.1_Silent_p.R127R	NM_014841	NP_055656	O60641	AP180_HUMAN	synaptosomal-associated protein, 91kDa homolog	246					clathrin coat assembly	clathrin coat|coated pit|plasma membrane	1-phosphatidylinositol binding|clathrin binding			ovary(1)	1		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;2.91e-07)|all_hematologic(105;0.000337)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0967)		ATTCAGACACTCGTGTCATTC	0.279		NA											5	4					0	0	0	0
SNX14	57231	broad.mit.edu	37	6	86223949	86223949	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:86223949C>A	uc003pkr.2	-	25	2589	c.2396G>T	c.(2395-2397)CGG>CTG	p.R799L	SNX14_uc003pkp.2_Missense_Mutation_p.R662L|SNX14_uc003pkq.2_Missense_Mutation_p.R405L|SNX14_uc011dzg.1_Missense_Mutation_p.R747L|SNX14_uc003pks.2_Missense_Mutation_p.R746L|SNX14_uc003pkt.2_Missense_Mutation_p.R790L	NM_153816	NP_722523	Q9Y5W7	SNX14_HUMAN	sorting nexin 14 isoform a	799					cell communication|protein transport	integral to membrane	phosphatidylinositol binding|signal transducer activity				0		all_cancers(76;4.83e-07)|Acute lymphoblastic leukemia(125;3.3e-08)|Prostate(29;2.55e-07)|all_hematologic(105;3.66e-05)|all_epithelial(107;0.000695)|Lung NSC(302;0.197)|all_lung(197;0.24)		BRCA - Breast invasive adenocarcinoma(108;0.0423)		GAAAACTACCCGTCCTGAGAA	0.378		NA											24	50					3.6e-14	6.85e-14	1	0
HTR1E	3354	broad.mit.edu	37	6	87725582	87725582	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:87725582A>T	uc003pli.2	+	2	1233	c.530A>T	c.(529-531)CAC>CTC	p.H177L		NM_000865	NP_000856	P28566	5HT1E_HUMAN	5-hydroxytryptamine (serotonin) receptor 1E	177	Extracellular (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	protein binding|serotonin binding|serotonin receptor activity			ovary(2)|skin(1)	3		all_cancers(76;7.11e-06)|Acute lymphoblastic leukemia(125;1.2e-09)|Prostate(29;3.51e-09)|all_hematologic(105;7.43e-06)|all_epithelial(107;0.00819)		BRCA - Breast invasive adenocarcinoma(108;0.055)	Eletriptan(DB00216)	ACCATCCAGCACGACCATGTT	0.522		NA											19	69					0	0	0	0
PNRC1	10957	broad.mit.edu	37	6	89790894	89790894	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:89790894C>G	uc003pmv.2	+	1	466	c.281C>G	c.(280-282)CCG>CGG	p.P94R	PNRC1_uc003pmu.2_Missense_Mutation_p.P94R|PNRC1_uc003pmx.2_5'Flank	NM_006813	NP_006804	Q12796	PNRC1_HUMAN	proline-rich nuclear receptor coactivator 1	94	Nuclear localization signal.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding				0		all_cancers(76;3.64e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00527)		BRCA - Breast invasive adenocarcinoma(108;0.102)		CGGGCAGCGCCGAAGAAGCGG	0.721		NA								Multiple Myeloma(7;0.094)			6	14					0	0	0	0
SIM1	6492	broad.mit.edu	37	6	100838661	100838661	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:100838661T>A	uc003pqj.3	-	11	2084	c.1877A>T	c.(1876-1878)AAC>ATC	p.N626I	SIM1_uc010kcu.2_Missense_Mutation_p.N626I	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	626	Single-minded C-terminal.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		TGGTGAAGTGTTGGCAAGAGC	0.493		NA											53	123					0	0	0	0
RTN4IP1	84816	broad.mit.edu	37	6	107069363	107069363	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:107069363C>T	uc003prj.2	-	3	909	c.432G>A	c.(430-432)TGG>TGA	p.W144*	RTN4IP1_uc010kdd.2_Nonsense_Mutation_p.W144*|RTN4IP1_uc003prk.2_Nonsense_Mutation_p.W44*	NM_032730	NP_116119	Q8WWV3	RT4I1_HUMAN	reticulon 4 interacting protein 1 precursor	144						mitochondrion	oxidoreductase activity|zinc ion binding				0	Breast(9;0.0107)|all_epithelial(6;0.14)	all_cancers(87;9.45e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.0144)	Epithelial(6;0.000873)|all cancers(7;0.00363)|BRCA - Breast invasive adenocarcinoma(8;0.00721)|OV - Ovarian serous cystadenocarcinoma(5;0.0394)	all cancers(137;0.113)|BRCA - Breast invasive adenocarcinoma(108;0.127)|Epithelial(106;0.144)		GAACTGCAGCCCAGACCTGAA	0.418		NA											26	95					0	0	0	0
KIAA1919	91749	broad.mit.edu	37	6	111587866	111587866	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:111587866G>T	uc003puv.3	+	4	1523	c.1101G>T	c.(1099-1101)ATG>ATT	p.M367I		NM_153369	NP_699200	Q5TF39	NAGT1_HUMAN	sodium-dependent glucose transporter 1	367	Helical; (Potential).				carbohydrate transport|sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			ovary(3)	3		all_cancers(87;2.35e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.0209)		OV - Ovarian serous cystadenocarcinoma(136;0.055)|all cancers(137;0.0871)|Epithelial(106;0.0884)		TGGGAGAAATGGCTATTCCTG	0.423		NA											34	97					1.31e-24	2.73e-24	1	0
C6orf174	387104	broad.mit.edu	37	6	127836029	127836029	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:127836029C>A	uc003qbd.2	-	3	2130	c.1265G>T	c.(1264-1266)CGC>CTC	p.R422L		NM_001012279	NP_001012279	Q5TF21	CF174_HUMAN	hypothetical protein LOC387104 precursor	422	Potential.					integral to membrane				breast(3)|ovary(2)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.026)|all cancers(137;0.161)		CTGGGCGTAGCGGAGCCTTTT	0.657		NA											23	63					3.01e-09	5.26e-09	1	0
SAMD3	154075	broad.mit.edu	37	6	130535481	130535481	+	Splice_Site	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:130535481C>T	uc003qbv.2	-	5	595	c.269_splice	c.e5+1	p.D90_splice	SAMD3_uc003qbx.2_Splice_Site_p.D90_splice|SAMD3_uc003qbw.2_Splice_Site_p.D90_splice|SAMD3_uc010kfg.1_Splice_Site_p.D90_splice|SAMD3_uc003qby.2_Splice_Site_p.D90_splice|SAMD3_uc003qbz.1_Splice_Site_p.D49_splice	NM_001017373	NP_001017373	Q8N6K7	SAMD3_HUMAN	sterile alpha motif domain containing 3 isoform											ovary(1)	1				GBM - Glioblastoma multiforme(226;0.00594)|OV - Ovarian serous cystadenocarcinoma(155;0.128)		AACATACTCACTCTCGAGCTG	0.433		NA											25	68					0	0	0	0
SAMD3	154075	broad.mit.edu	37	6	130536394	130536394	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:130536394C>G	uc003qbv.2	-	4	351	c.25G>C	c.(25-27)GTC>CTC	p.V9L	SAMD3_uc003qbx.2_Missense_Mutation_p.V9L|SAMD3_uc003qbw.2_Missense_Mutation_p.V9L|SAMD3_uc010kfg.1_Missense_Mutation_p.V9L|SAMD3_uc003qby.2_Missense_Mutation_p.V9L|SAMD3_uc003qbz.1_5'UTR	NM_001017373	NP_001017373	Q8N6K7	SAMD3_HUMAN	sterile alpha motif domain containing 3 isoform	9	SAM.									ovary(1)	1				GBM - Glioblastoma multiforme(226;0.00594)|OV - Ovarian serous cystadenocarcinoma(155;0.128)		CAACTGCAGACCTGCTCAACT	0.398		NA											10	41					0	0	0	0
ENPP1	5167	broad.mit.edu	37	6	132172336	132172336	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:132172336G>T	uc011ecf.1	+	4	505	c.485G>T	c.(484-486)AGC>ATC	p.S162I		NM_006208	NP_006199	P22413	ENPP1_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	162	Extracellular (Potential).|SMB 2.				3'-phosphoadenosine 5'-phosphosulfate metabolic process|biomineral tissue development|cellular phosphate ion homeostasis|cellular response to insulin stimulus|generation of precursor metabolites and energy|immune response|inorganic diphosphate transport|negative regulation of cell growth|negative regulation of fat cell differentiation|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of protein autophosphorylation|nucleoside triphosphate catabolic process|phosphate metabolic process|sequestering of triglyceride|water-soluble vitamin metabolic process	basolateral plasma membrane|cell surface|extracellular space|integral to membrane	ATP binding|insulin receptor binding|metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|protein homodimerization activity|scavenger receptor activity			upper_aerodigestive_tract(2)|ovary(2)	4	Breast(56;0.0505)			GBM - Glioblastoma multiforme(226;0.0216)|OV - Ovarian serous cystadenocarcinoma(155;0.022)	Amifostine(DB01143)|Ribavirin(DB00811)	TTGACCAGAAGCCTCTGTGCC	0.458		NA											32	61					2.42e-17	4.8e-17	1	0
STX7	8417	broad.mit.edu	37	6	132824653	132824653	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:132824653C>A	uc003qdg.2	-	2	267	c.17G>T	c.(16-18)GGA>GTA	p.G6V	STX7_uc011ecg.1_RNA|STX7_uc011ech.1_Missense_Mutation_p.G6V	NM_003569	NP_003560	O15400	STX7_HUMAN	syntaxin 7	6	Cytoplasmic (Potential).				intracellular protein transport|post-Golgi vesicle-mediated transport	early endosome membrane|integral to membrane	SNAP receptor activity				0	Breast(56;0.0615)			OV - Ovarian serous cystadenocarcinoma(155;0.00532)|GBM - Glioblastoma multiforme(226;0.0114)		ACCACCAACTCCTGGAGTGTA	0.413		NA											31	72					4.11e-13	7.7e-13	1	0
VNN2	8875	broad.mit.edu	37	6	133072643	133072643	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:133072643C>G	uc003qdt.2	-	5	852	c.841G>C	c.(841-843)GCA>CCA	p.A281P	VNN2_uc003qds.2_5'UTR|VNN2_uc010kgb.2_Intron|VNN2_uc003qdv.2_Missense_Mutation_p.A228P	NM_004665	NP_004656	O95498	VNN2_HUMAN	vanin 2 isoform 1 precursor	281	CN hydrolase.				cellular component movement|pantothenate metabolic process	anchored to membrane|plasma membrane	pantetheine hydrolase activity				0				OV - Ovarian serous cystadenocarcinoma(155;0.00237)|GBM - Glioblastoma multiforme(226;0.0267)		CCATTTGGTGCATAAATACCA	0.413		NA											23	45					0	0	0	0
C6orf192	116843	broad.mit.edu	37	6	133110904	133110904	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:133110904C>G	uc003qdw.1	-	4	504	c.352G>C	c.(352-354)GGT>CGT	p.G118R	C6orf192_uc011eco.1_Missense_Mutation_p.W41S	NM_052831	NP_439896	Q6NT16	CF192_HUMAN	hypothetical protein LOC116843	118	Helical; (Potential).				transmembrane transport	integral to membrane				ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(155;0.00303)|GBM - Glioblastoma multiforme(226;0.0265)		ATGACTTACCCAAAGAGAATT	0.308		NA											26	72					0	0	0	0
KIAA1244	57221	broad.mit.edu	37	6	138576847	138576847	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:138576847C>A	uc003qhu.2	+	10	1045	c.1045C>A	c.(1045-1047)CGA>AGA	p.R349R		NM_020340	NP_065073	Q5TH69	BIG3_HUMAN	brefeldin A-inhibited guanine	349					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)|skin(1)	2	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		CCTCTACCACCGAGTGCTGCT	0.602		NA											6	14					0.00116845	0.00172167	1	0
ECT2L	345930	broad.mit.edu	37	6	139170518	139170518	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:139170518A>C	uc003qif.1	+	7	1119	c.1016A>C	c.(1015-1017)CAG>CCG	p.Q339P	ECT2L_uc011edq.1_Missense_Mutation_p.Q270P	NM_001077706	NP_001071174	Q008S8	ECT2L_HUMAN	epithelial cell transforming sequence 2	339					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity				0						CAGAAGGCACAGAGCATCGGA	0.468		NA											21	62					0	0	0	0
PLAGL1	5325	broad.mit.edu	37	6	144263314	144263314	+	Silent	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:144263314T>C	uc003qjv.2	-	3	1905	c.639A>G	c.(637-639)AAA>AAG	p.K213K	PLAGL1_uc003qjx.2_Silent_p.K213K|PLAGL1_uc003qjy.2_Silent_p.K213K|PLAGL1_uc010khl.2_Silent_p.K213K|PLAGL1_uc010khm.2_Silent_p.K213K|PLAGL1_uc003qjz.2_Silent_p.K213K|PLAGL1_uc003qka.2_Silent_p.K213K|PLAGL1_uc003qkb.2_Silent_p.K161K|PLAGL1_uc003qkc.2_Silent_p.K213K|PLAGL1_uc003qkd.2_Silent_p.K161K|PLAGL1_uc003qke.2_Silent_p.K213K|PLAGL1_uc003qkf.2_Silent_p.K213K|PLAGL1_uc003qkg.2_Silent_p.K161K|PLAGL1_uc003qkh.2_Silent_p.K213K|PLAGL1_uc003qki.2_Silent_p.K161K|PLAGL1_uc003qkj.2_Silent_p.K213K|PLAGL1_uc003qkk.2_Silent_p.K161K|PLAGL1_uc003qkl.2_Silent_p.K161K|PLAGL1_uc003qkm.2_Silent_p.K213K|PLAGL1_uc010khn.2_Silent_p.K213K|PLAGL1_uc003qkn.2_Silent_p.K161K|PLAGL1_uc003qko.2_Silent_p.K213K|PLAGL1_uc003qkp.2_Silent_p.K161K|PLAGL1_uc003qjw.2_Silent_p.K161K	NM_002656	NP_002647	Q9UM63	PLAL1_HUMAN	pleiomorphic adenoma gene-like 1 isoform 1	213					cell cycle arrest|induction of apoptosis|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(155;5.74e-07)|GBM - Glioblastoma multiforme(68;0.0885)		GCAAGCTCTCTTTCATCAGCT	0.547		NA									OREG0017707	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	41	107					0	0	0	0
PCMT1	5110	broad.mit.edu	37	6	150094294	150094294	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:150094294G>T	uc003qne.2	+	3	388	c.355G>T	c.(355-357)GCT>TCT	p.A119S	PCMT1_uc003qna.2_Missense_Mutation_p.A119S|PCMT1_uc003qnb.2_Missense_Mutation_p.A119S|PCMT1_uc011eeg.1_Missense_Mutation_p.A84S|PCMT1_uc003qnc.2_5'UTR|PCMT1_uc003qnd.2_Missense_Mutation_p.A119S|PCMT1_uc003qnf.2_Missense_Mutation_p.A119S	NM_005389	NP_005380			protein-L-isoaspartate (D-aspartate)											ovary(1)	1		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.221)	OV - Ovarian serous cystadenocarcinoma(155;5.63e-13)|GBM - Glioblastoma multiforme(68;0.207)		AACAATCAGTGCTCCACACAT	0.303		NA											20	45					6.21e-17	1.23e-16	1	0
AKAP12	9590	broad.mit.edu	37	6	151670376	151670376	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:151670376C>A	uc011eep.1	+	4	1090	c.850C>A	c.(850-852)CCG>ACG	p.P284T	AKAP12_uc003qoe.2_Missense_Mutation_p.P284T|AKAP12_uc003qof.2_Missense_Mutation_p.P186T|AKAP12_uc010kim.2_Intron|AKAP12_uc003qog.2_Missense_Mutation_p.P179T	NM_005100	NP_005091	Q02952	AKA12_HUMAN	A kinase (PRKA) anchor protein 12 isoform 1	284	Involved in PKC-binding (Probable).				G-protein coupled receptor protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting	cell cortex|cytoskeleton|plasma membrane	adenylate cyclase binding|protein kinase A binding			large_intestine(2)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	8		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.98e-11)		TGCAGAATCTCCGACTAGTCC	0.483		NA											16	33					2.32e-05	3.65e-05	1	0
AKAP12	9590	broad.mit.edu	37	6	151673277	151673277	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:151673277T>A	uc011eep.1	+	4	3991	c.3751T>A	c.(3751-3753)TCA>ACA	p.S1251T	AKAP12_uc003qoe.2_Missense_Mutation_p.S1251T|AKAP12_uc003qof.2_Missense_Mutation_p.S1153T|AKAP12_uc010kim.2_Intron|AKAP12_uc003qog.2_Missense_Mutation_p.S1146T	NM_005100	NP_005091	Q02952	AKA12_HUMAN	A kinase (PRKA) anchor protein 12 isoform 1	1251					G-protein coupled receptor protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting	cell cortex|cytoskeleton|plasma membrane	adenylate cyclase binding|protein kinase A binding			large_intestine(2)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	8		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.98e-11)		TAAAGAGGTGTCAGTGGAAAC	0.438		NA											11	30					0	0	0	0
ESR1	2099	broad.mit.edu	37	6	152382208	152382208	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:152382208C>T	uc003qom.3	+	8	1688	c.1318C>T	c.(1318-1320)CTG>TTG	p.L440L	ESR1_uc010kin.2_Silent_p.L440L|ESR1_uc010kio.2_Silent_p.L442L|ESR1_uc010kip.2_Silent_p.L439L|ESR1_uc003qon.3_Silent_p.L440L|ESR1_uc003qoo.3_Silent_p.L440L|ESR1_uc010kiq.2_Silent_p.L38L|ESR1_uc010kir.2_Silent_p.L179L|ESR1_uc011eet.1_Intron|ESR1_uc011eeu.1_RNA|ESR1_uc011eev.1_Intron|ESR1_uc011eew.1_Intron|ESR1_uc010kis.2_Silent_p.L109L|ESR1_uc011eex.1_Intron|ESR1_uc010kit.1_3'UTR|ESR1_uc011eey.1_Silent_p.L177L	NM_001122742	NP_001116214	P03372	ESR1_HUMAN	estrogen receptor alpha isoform 4	440	Steroid-binding.|Interaction with AKAP13.				positive regulation of retinoic acid receptor signaling pathway|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to estradiol stimulus	chromatin remodeling complex|cytoplasm|nucleoplasm	beta-catenin binding|enzyme binding|estrogen receptor activity|estrogen response element binding|nitric-oxide synthase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|zinc ion binding			central_nervous_system(2)|ovary(1)|lung(1)|breast(1)	5		Ovarian(120;0.0448)	BRCA - Breast invasive adenocarcinoma(37;0.0841)	OV - Ovarian serous cystadenocarcinoma(155;4.55e-10)	Chlorotrianisene(DB00269)|Clomifene(DB00882)|Conjugated Estrogens(DB00286)|Danazol(DB01406)|Desogestrel(DB00304)|Dienestrol(DB00890)|Diethylstilbestrol(DB00255)|Dromostanolone(DB00858)|Drospirenone(DB01395)|Estradiol(DB00783)|Estramustine(DB01196)|Estriol(DB04573)|Estrone(DB00655)|Ethinyl Estradiol(DB00977)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Fluoxymesterone(DB01185)|Fulvestrant(DB00947)|Letrozole(DB01006)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Melatonin(DB01065)|Mestranol(DB01357)|Naloxone(DB01183)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)|Quinestrol(DB04575)|Raloxifene(DB00481)|Tamoxifen(DB00675)|Toremifene(DB00539)	CATGATGAATCTGCAGGGAGA	0.413		NA											13	15					0	0	0	0
SYNE1	23345	broad.mit.edu	37	6	152529267	152529267	+	Missense_Mutation	SNP	C	C	A	rs149366576		TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:152529267C>A	uc010kiw.2	-	125	23266	c.22664G>T	c.(22663-22665)CGG>CTG	p.R7555L	SYNE1_uc010kiv.2_Missense_Mutation_p.R2079L|SYNE1_uc003qos.3_Missense_Mutation_p.R2079L|SYNE1_uc003qot.3_Missense_Mutation_p.R7484L|SYNE1_uc003qou.3_Missense_Mutation_p.R7555L|SYNE1_uc003qor.3_Missense_Mutation_p.R455L	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	7555	HAT 11.|Cytoplasmic (Potential).|Spectrin 25.				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		AATGATCCCCCGCCTCTGCTG	0.488		NA								HNSCC(10;0.0054)			30	53					2.61e-14	4.98e-14	1	0
SYNE1	23345	broad.mit.edu	37	6	152725381	152725381	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:152725381T>G	uc010kiw.2	-	46	7394	c.6792A>C	c.(6790-6792)TTA>TTC	p.L2264F	SYNE1_uc003qot.3_Missense_Mutation_p.L2271F|SYNE1_uc003qou.3_Missense_Mutation_p.L2264F|SYNE1_uc010kjb.1_Missense_Mutation_p.L2247F	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2264	Potential.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GATTTTTAGTTAATTCTTTCA	0.328		NA								HNSCC(10;0.0054)			40	63					0	0	0	0
SYNE1	23345	broad.mit.edu	37	6	152831418	152831418	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:152831418G>A	uc010kiw.2	-	8	1093	c.491C>T	c.(490-492)CCC>CTC	p.P164L	SYNE1_uc003qot.3_Missense_Mutation_p.P171L|SYNE1_uc003qou.3_Missense_Mutation_p.P164L|SYNE1_uc010kjb.1_Missense_Mutation_p.P164L|SYNE1_uc003qpa.1_Missense_Mutation_p.P164L	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	164	Actin-binding.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TGGTGGGCTGGGAGTCTCAGA	0.493		NA								HNSCC(10;0.0054)			25	66					0	0	0	0
CNKSR3	154043	broad.mit.edu	37	6	154762449	154762449	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:154762449C>G	uc003qpy.2	-	4	989	c.484G>C	c.(484-486)GAC>CAC	p.D162H		NM_173515	NP_775786	Q6P9H4	CNKR3_HUMAN	CNKSR family member 3	162	CRIC.				negative regulation of ERK1 and ERK2 cascade|negative regulation of peptidyl-serine phosphorylation|positive regulation of sodium ion transport	cytoplasm|membrane				ovary(2)|breast(1)|skin(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;5.03e-11)|BRCA - Breast invasive adenocarcinoma(81;0.00627)		GTGGTCAGGTCCAAGCAAAGC	0.368		NA											35	76					0	0	0	0
SERAC1	84947	broad.mit.edu	37	6	158569896	158569896	+	Splice_Site	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:158569896C>G	uc003qrc.2	-	5	497	c.355_splice	c.e5+1	p.D119_splice	SERAC1_uc003qrb.2_Splice_Site	NM_032861	NP_116250	Q96JX3	SRAC1_HUMAN	serine active site containing 1						GPI anchor metabolic process|intracellular protein transport	integral to membrane|intrinsic to endoplasmic reticulum membrane	binding|hydrolase activity, acting on ester bonds				0		Breast(66;0.00519)|Ovarian(120;0.123)|Prostate(117;0.178)		OV - Ovarian serous cystadenocarcinoma(65;1.37e-18)|BRCA - Breast invasive adenocarcinoma(81;3.19e-05)		TGGATATTTACCAGCAAATGG	0.338		NA											9	29					0	0	0	0
T	6862	broad.mit.edu	37	6	166571922	166571922	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:166571922C>A	uc003quu.1	-	9	1682	c.1189G>T	c.(1189-1191)GGA>TGA	p.G397*	T_uc003qut.1_Nonsense_Mutation_p.G398*|T_uc003quv.1_Nonsense_Mutation_p.G339*	NM_003181	NP_003172	O15178	BRAC_HUMAN	transcription factor T	397					anterior/posterior axis specification, embryo|mesoderm development|primitive streak formation	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2		Prostate(117;4.48e-07)|Ovarian(120;1.78e-06)|Breast(66;2.54e-06)|Lung SC(201;0.0225)|Esophageal squamous(34;0.0559)		OV - Ovarian serous cystadenocarcinoma(33;1.09e-113)|GBM - Glioblastoma multiforme(31;1.51e-108)|BRCA - Breast invasive adenocarcinoma(81;8.45e-09)|LUAD - Lung adenocarcinoma(999;0.0407)		AGTGGGGATCCCGAGGAAGAG	0.692		NA							Chordoma_Familial_Clustering_of				21	69					9.96e-16	1.94e-15	1	0
KIF25	3834	broad.mit.edu	37	6	168434642	168434642	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:168434642G>A	uc003qwk.1	+	4	510	c.248G>A	c.(247-249)GGC>GAC	p.G83D	KIF25_uc003qwl.1_Missense_Mutation_p.G83D	NM_030615	NP_085118	Q9UIL4	KIF25_HUMAN	kinesin family member 25 isoform 1	83	Kinesin-motor.				microtubule-based movement|mitotic sister chromatid segregation	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			ovary(1)|pancreas(1)	2		Breast(66;1.07e-05)|Ovarian(120;0.0728)		Epithelial(4;7.7e-30)|OV - Ovarian serous cystadenocarcinoma(33;5.82e-22)|BRCA - Breast invasive adenocarcinoma(4;1.38e-10)|GBM - Glioblastoma multiforme(31;0.000756)		TCGGACGACGGCCCTGTTCTG	0.527		NA											17	39					0	0	0	0
SDK1	221935	broad.mit.edu	37	7	4091359	4091359	+	Silent	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:4091359G>C	uc003smx.2	+	19	2947	c.2808G>C	c.(2806-2808)ACG>ACC	p.T936T	SDK1_uc010kso.2_Silent_p.T212T	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	936	Fibronectin type-III 3.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		GACACATAACGAACCTGAAGA	0.577		NA											40	83					0	0	0	0
KIAA0415	9907	broad.mit.edu	37	7	4830976	4830976	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:4830976G>T	uc003sne.2	+	17	2467	c.2384G>T	c.(2383-2385)AGC>ATC	p.S795I	KIAA0415_uc010ksp.2_RNA|KIAA0415_uc003snf.2_Missense_Mutation_p.S272I	NM_014855	NP_055670	O43299	K0415_HUMAN	hypothetical protein LOC9907	795					cell death|double-strand break repair via homologous recombination	cytoplasm|nucleus	protein binding			central_nervous_system(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.091)|OV - Ovarian serous cystadenocarcinoma(56;8.35e-15)		CGCACGGTCAGCCGGCTGGTG	0.672		NA											8	7					1.13e-05	1.8e-05	1	0
USP42	84132	broad.mit.edu	37	7	6189425	6189425	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:6189425G>T	uc011jwo.1	+	13	1721	c.1598G>T	c.(1597-1599)CGC>CTC	p.R533L	USP42_uc010kth.1_Missense_Mutation_p.R466L|USP42_uc011jwp.1_Missense_Mutation_p.R533L|USP42_uc011jwq.1_Missense_Mutation_p.R340L|USP42_uc011jwr.1_Missense_Mutation_p.R378L	NM_032172	NP_115548	Q9H9J4	UBP42_HUMAN	ubiquitin specific peptidase 42	533					cell differentiation|protein deubiquitination|spermatogenesis|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			skin(2)|ovary(1)|pancreas(1)|breast(1)	5		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.108)|OV - Ovarian serous cystadenocarcinoma(56;5.77e-14)		TTGCCTGTTCGCCAGTGTCAG	0.428		NA											21	49					8.34e-07	1.37e-06	1	0
C1GALT1	56913	broad.mit.edu	37	7	7278538	7278538	+	Nonsense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:7278538T>A	uc010ktn.2	+	3	1096	c.873T>A	c.(871-873)TAT>TAA	p.Y291*	C1GALT1_uc003sra.2_Nonsense_Mutation_p.Y291*|C1GALT1_uc010kto.1_Nonsense_Mutation_p.Y291*	NM_020156	NP_064541	Q9NS00	C1GLT_HUMAN	core 1 synthase,	291	Lumenal (Potential).				angiogenesis|cell differentiation|kidney development	integral to membrane	glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity|metal ion binding				0				UCEC - Uterine corpus endometrioid carcinoma (126;0.177)		ATTACAACTATTATCCTCCTG	0.313		NA											10	26					0	0	0	0
ARL4A	10124	broad.mit.edu	37	7	12728069	12728069	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:12728069G>C	uc003ssp.2	+	2	467	c.190G>C	c.(190-192)GGA>CGA	p.G64R	ARL4A_uc003ssq.2_Missense_Mutation_p.G64R|ARL4A_uc003ssr.2_Missense_Mutation_p.G64R|ARL4A_uc003sss.2_Missense_Mutation_p.G64R	NM_001037164	NP_001032241	P40617	ARL4A_HUMAN	ADP-ribosylation factor-like 4A	64					small GTPase mediated signal transduction	cytoplasm|nucleolus|plasma membrane	GTP binding|protein binding				0				UCEC - Uterine corpus endometrioid carcinoma (126;0.176)		GGTAACCTTGGGAAATTCTAA	0.398		NA											12	48					0	0	0	0
HOXA7	3204	broad.mit.edu	37	7	27196162	27196162	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:27196162C>T	uc003sys.2	-	1	135	c.3G>A	c.(1-3)ATG>ATA	p.M1I		NM_006896	NP_008827	P31268	HXA7_HUMAN	homeobox A7	1					angiogenesis|negative regulation of cell-matrix adhesion|negative regulation of keratinocyte differentiation|negative regulation of leukocyte migration|negative regulation of monocyte differentiation|negative regulation of transcription from RNA polymerase II promoter		sequence-specific DNA binding|transcription factor binding				0						ACGAAGAACTCATAATTTTGA	0.443		NA											30	97					0	0	0	0
CCDC129	223075	broad.mit.edu	37	7	31682573	31682573	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:31682573G>A	uc003tcj.1	+	11	2582	c.1589G>A	c.(1588-1590)AGG>AAG	p.R530K	CCDC129_uc011kad.1_Missense_Mutation_p.R540K|CCDC129_uc003tci.1_Missense_Mutation_p.R381K|CCDC129_uc011kae.1_Missense_Mutation_p.R556K|CCDC129_uc003tck.1_Missense_Mutation_p.R438K	NM_194300	NP_919276	Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	530											0						ACCACCACGAGGGGAGAATGC	0.547		NA											56	125					0	0	0	0
PDE1C	5137	broad.mit.edu	37	7	31890356	31890356	+	Splice_Site	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:31890356C>G	uc003tcm.1	-	8	1220	c.751_splice	c.e8-1	p.N251_splice	PDE1C_uc003tcn.1_Splice_Site_p.N251_splice|PDE1C_uc003tco.1_Splice_Site_p.N311_splice|PDE1C_uc003tcr.2_Splice_Site_p.N251_splice|PDE1C_uc003tcs.2_Splice_Site_p.N251_splice	NM_005020	NP_005011	Q14123	PDE1C_HUMAN	phosphodiesterase 1C						activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(3)|central_nervous_system(1)	4			GBM - Glioblastoma multiforme(11;0.216)			TCAGCCAGTTCTGAAAGGAGA	0.468		NA											17	44					0	0	0	0
PDE1C	5137	broad.mit.edu	37	7	31917614	31917614	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:31917614C>G	uc003tcm.1	-	5	930	c.461G>C	c.(460-462)AGC>ACC	p.S154T	PDE1C_uc003tcn.1_Missense_Mutation_p.S154T|PDE1C_uc003tco.1_Missense_Mutation_p.S214T|PDE1C_uc003tcr.2_Missense_Mutation_p.S154T|PDE1C_uc003tcs.2_Missense_Mutation_p.S154T	NM_005020	NP_005011	Q14123	PDE1C_HUMAN	phosphodiesterase 1C	154					activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(3)|central_nervous_system(1)	4			GBM - Glioblastoma multiforme(11;0.216)			TGGTGGATAGCTCAGTCCAAC	0.338		NA											6	28					0	0	0	0
AVL9	23080	broad.mit.edu	37	7	32590986	32590986	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:32590986C>T	uc003tcv.1	+	5	559	c.413C>T	c.(412-414)ACA>ATA	p.T138I	AVL9_uc011kai.1_Missense_Mutation_p.T138I|AVL9_uc010kwj.1_5'UTR	NM_015060	NP_055875	Q8NBF6	AVL9_HUMAN	AVL9 homolog (S. cerevisiase)	138						integral to membrane					0						CAACTCATTACACATGCATAT	0.308		NA											16	102					0	0	0	0
HERPUD2	64224	broad.mit.edu	37	7	35673920	35673920	+	Splice_Site	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:35673920A>G	uc003tet.2	-	7	1864	c.1059_splice	c.e7+1	p.M353_splice	HERPUD2_uc003tes.3_Splice_Site_p.M353_splice	NM_022373	NP_071768	Q9BSE4	HERP2_HUMAN	HERPUD family member 2						response to unfolded protein	integral to membrane				ovary(3)	3						TCAATCACATACCATTTCTTC	0.393		NA											12	34					0	0	0	0
TXNDC3	51314	broad.mit.edu	37	7	37903047	37903047	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:37903047C>A	uc003tfn.2	+	8	809	c.437C>A	c.(436-438)TCA>TAA	p.S146*		NM_016616	NP_057700	Q8N427	TXND3_HUMAN	thioredoxin domain containing 3	146					cell differentiation|cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatogenesis|UTP biosynthetic process	cytoplasm|microtubule cytoskeleton	ATP binding|nucleoside diphosphate kinase activity			ovary(1)|breast(1)|central_nervous_system(1)	3						AGTGAAGAATCACCATGTGAA	0.348		NA							Kartagener_syndrome				20	59					2.94e-08	5.05e-08	1	0
TXNDC3	51314	broad.mit.edu	37	7	37934211	37934211	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:37934211G>C	uc003tfn.2	+	16	1915	c.1543G>C	c.(1543-1545)GTG>CTG	p.V515L		NM_016616	NP_057700	Q8N427	TXND3_HUMAN	thioredoxin domain containing 3	515	NDK 3.				cell differentiation|cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatogenesis|UTP biosynthetic process	cytoplasm|microtubule cytoskeleton	ATP binding|nucleoside diphosphate kinase activity			ovary(1)|breast(1)|central_nervous_system(1)	3						AATGTTATCTGTGTAAGTTTC	0.204		NA							Kartagener_syndrome				5	13					0	0	0	0
SFRP4	6424	broad.mit.edu	37	7	37951857	37951858	+	Missense_Mutation	DNP	CC	CC	AG			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:37951857_37951858CC>AG	uc003tfo.3	-	4	1040_1041	c.654_655GG>CT	c.(652-657)GTGGAT>GTCTAT	p.D219Y		NM_003014	NP_003005	Q6FHJ7	SFRP4_HUMAN	secreted frizzled-related  protein 4 precursor	219	NTR.				brain development|cell differentiation|decidualization|embryo development|epithelium development|gonad development|mammary gland involution|menstrual cycle phase|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell proliferation|negative regulation of JNK cascade|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of sodium-dependent phosphate transport|phosphate ion homeostasis|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epidermal cell differentiation|positive regulation of gene expression|positive regulation of receptor internalization|vasculature development|Wnt receptor signaling pathway	cell surface|cytoplasm|extracellular space|nucleus	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(1)	1						TCTTTTACATCCACCACCGTTG	0.431		NA											18	47					0	0	0	0
C7orf10	79783	broad.mit.edu	37	7	40234623	40234623	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:40234623G>C	uc003thn.1	+	6	493	c.448G>C	c.(448-450)GAG>CAG	p.E150Q	C7orf10_uc003thm.1_Intron|C7orf10_uc003tho.1_Missense_Mutation_p.E150Q	NM_024728	NP_079004	Q9HAC7	CG010_HUMAN	dermal papilla derived protein 13	157							transferase activity			ovary(2)	2						AGATATAGACGAGATTGCTCC	0.428		NA											44	138					0	0	0	0
C7orf10	79783	broad.mit.edu	37	7	40498771	40498771	+	Silent	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:40498771A>G	uc003thn.1	+	11	1005	c.960A>G	c.(958-960)AAA>AAG	p.K320K	C7orf10_uc003thm.1_Silent_p.K290K|C7orf10_uc003tho.1_Silent_p.K272K	NM_024728	NP_079004	Q9HAC7	CG010_HUMAN	dermal papilla derived protein 13	327							transferase activity			ovary(2)	2						ACAATAGAAAAGAGCTTATTA	0.279		NA											7	31					0	0	0	0
GLI3	2737	broad.mit.edu	37	7	42005670	42005670	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:42005670C>A	uc011kbh.1	-	15	3092	c.3001G>T	c.(3001-3003)GGC>TGC	p.G1001C	GLI3_uc011kbg.1_Missense_Mutation_p.G942C	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	1001					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						CTCCTCACGCCGTGGCCCGGC	0.756		NA							Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				8	10					0.000274275	0.000411185	1	0
TNS3	64759	broad.mit.edu	37	7	47408665	47408665	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:47408665G>T	uc003tnv.2	-	17	1945	c.1578C>A	c.(1576-1578)GGC>GGA	p.G526G	TNS3_uc003tnw.2_Silent_p.G526G	NM_022748	NP_073585	Q68CZ2	TENS3_HUMAN	tensin 3	526						focal adhesion	protein binding			ovary(4)	4						CAACGTTGCTGCCAAAACCGT	0.627		NA											21	30					1.26e-06	2.08e-06	1	0
TNS3	64759	broad.mit.edu	37	7	47474985	47474985	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:47474985C>T	uc003tnv.2	-	8	586	c.219G>A	c.(217-219)TGG>TGA	p.W73*	TNS3_uc003tnw.2_Nonsense_Mutation_p.W73*|TNS3_uc010kyo.1_Nonsense_Mutation_p.W73*	NM_022748	NP_073585	Q68CZ2	TENS3_HUMAN	tensin 3	73	Phosphatase tensin-type.					focal adhesion	protein binding			ovary(4)	4						GGAGCTCTGGCCAGCCCACAT	0.517		NA											25	81					0	0	0	0
C7orf57	136288	broad.mit.edu	37	7	48080958	48080958	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:48080958G>T	uc003toh.3	+	3	295	c.83G>T	c.(82-84)CGC>CTC	p.R28L	C7orf57_uc003toi.3_5'UTR	NM_001100159	NP_001093629	Q8NEG2	CG057_HUMAN	hypothetical protein LOC136288	28										ovary(1)	1						CCAGTGAAGCGCTCTGAGAAG	0.582		NA											10	43					2.81e-09	4.9e-09	1	0
ABCA13	154664	broad.mit.edu	37	7	48443395	48443395	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:48443395G>T	uc003toq.2	+	39	12014	c.11989G>T	c.(11989-11991)GTG>TTG	p.V3997L	ABCA13_uc010kys.1_Missense_Mutation_p.V1071L|ABCA13_uc003tos.1_Missense_Mutation_p.V823L|ABCA13_uc010kyt.1_RNA	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	3997	ABC transporter 1.				transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						GTCGAGGACCGTGGTTCTGGA	0.572		NA											9	25					1.77e-08	3.04e-08	1	0
ABCA13	154664	broad.mit.edu	37	7	48619833	48619833	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:48619833C>A	uc003toq.2	+	56	14393	c.14368C>A	c.(14368-14370)CTG>ATG	p.L4790M	ABCA13_uc010kys.1_Missense_Mutation_p.L1865M|ABCA13_uc010kyt.1_RNA|ABCA13_uc010kyu.1_Missense_Mutation_p.L520M	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	4790	ABC transporter 2.				transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						CGCCGTGGACCTGTCTTCTGC	0.522		NA											4	8					2.77e-08	4.76e-08	1	0
ZPBP	11055	broad.mit.edu	37	7	50070687	50070687	+	Splice_Site	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:50070687C>A	uc003tou.2	-	5	776	c.706_splice	c.e5+1	p.V236_splice	ZPBP_uc011kci.1_Splice_Site_p.V162_splice|ZPBP_uc010kyw.2_Splice_Site_p.V235_splice	NM_007009	NP_008940	Q9BS86	ZPBP1_HUMAN	zona pellucida binding protein isoform 1						binding of sperm to zona pellucida	extracellular region					0	Glioma(55;0.08)|all_neural(89;0.245)					TATAGACTTACCTGAAAATGC	0.299		NA											4	52					0.000602214	0.000897232	1	0
COBL	23242	broad.mit.edu	37	7	51261227	51261227	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:51261227T>A	uc003tpr.3	-	3	490	c.305A>T	c.(304-306)CAC>CTC	p.H102L	COBL_uc003tps.2_Missense_Mutation_p.H102L|COBL_uc011kcl.1_Missense_Mutation_p.H102L|COBL_uc010kzc.2_Missense_Mutation_p.H102L|COBL_uc003tpt.2_Missense_Mutation_p.H102L|COBL_uc003tpp.3_5'Flank|COBL_uc003tpq.3_Missense_Mutation_p.H18L	NM_015198	NP_056013	O75128	COBL_HUMAN	cordon-bleu homolog	102										skin(3)|ovary(2)	5	Glioma(55;0.08)					AAGGGCATGGTGGGATGGATT	0.413		NA											10	45					0	0	0	0
ZNF479	90827	broad.mit.edu	37	7	57188157	57188157	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:57188157T>G	uc010kzo.2	-	5	1236	c.965A>C	c.(964-966)GAG>GCG	p.E322A		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	zinc finger protein 479	322					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(1;9.18e-12)			GCAGGGTTTCTCTCCAGTATG	0.443		NA											15	37					0	0	0	0
ZNF716	441234	broad.mit.edu	37	7	57529257	57529257	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:57529257T>C	uc011kdi.1	+	4	1202	c.1090T>C	c.(1090-1092)TCC>CCC	p.S364P		NM_001159279	NP_001152751			zinc finger protein 716											ovary(2)	2						CTTTACCTTCTCCTCAACTCT	0.403		NA											8	22					0	0	0	0
ZNF107	51427	broad.mit.edu	37	7	64166767	64166767	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:64166767G>T	uc003ttd.2	+	7	871	c.85G>T	c.(85-87)GTG>TTG	p.V29L	ZNF107_uc003tte.2_Missense_Mutation_p.V29L	NM_016220	NP_057304	Q9UII5	ZN107_HUMAN	zinc finger protein 107	29					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(55;0.00948)|all_lung(88;0.0249)				TTTCCAGAAAGTGACACTGAG	0.358		NA											14	17					1.58e-08	2.73e-08	1	0
ZNF92	168374	broad.mit.edu	37	7	64863788	64863788	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:64863788A>G	uc003ttz.2	+	4	904	c.761A>G	c.(760-762)GAG>GGG	p.E254G	ZNF92_uc003tua.2_Missense_Mutation_p.E185G|ZNF92_uc010kzu.2_Missense_Mutation_p.E222G|ZNF92_uc003tub.2_Missense_Mutation_p.E178G	NM_152626	NP_689839	Q03936	ZNF92_HUMAN	zinc finger protein 92 isoform 2	254						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Lung NSC(55;0.159)				CATACTGGAGAGAAACCCTAC	0.348		NA											27	36					0	0	0	0
WBSCR17	64409	broad.mit.edu	37	7	71036356	71036356	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:71036356A>G	uc003tvy.2	+	6	1049	c.1049A>G	c.(1048-1050)TAC>TGC	p.Y350C	WBSCR17_uc003tvz.2_Missense_Mutation_p.Y49C	NM_022479	NP_071924	Q6IS24	GLTL3_HUMAN	UDP-GalNAc:polypeptide	350	Catalytic subdomain B.|Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				ATGGATGTATACGGAGGAGAA	0.512		NA											29	76					0	0	0	0
WBSCR28	135886	broad.mit.edu	37	7	73279506	73279506	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:73279506G>T	uc003tzk.2	+	2	292	c.256G>T	c.(256-258)GTC>TTC	p.V86F	RFC2_uc011kfa.1_Intron|WBSCR28_uc003tzl.2_5'UTR	NM_182504	NP_872310	Q6UE05	WBS28_HUMAN	hypothetical protein LOC135886	86	Helical; (Potential).					integral to membrane				breast(1)	1		Lung NSC(55;0.159)				TCTGATACAGGTCCCCGTATG	0.692		NA											34	75					4.03e-09	7.03e-09	1	0
GTF2IRD1	9569	broad.mit.edu	37	7	73969543	73969543	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:73969543G>T	uc003uaq.2	+	18	2349	c.1956G>T	c.(1954-1956)ATG>ATT	p.M652I	GTF2IRD1_uc010lbq.2_Missense_Mutation_p.M684I|GTF2IRD1_uc003uap.2_Silent_p.V652V|GTF2IRD1_uc003uar.1_Missense_Mutation_p.M652I	NM_016328	NP_057412	Q9UHL9	GT2D1_HUMAN	GTF2I repeat domain containing 1 isoform 1	652						nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(4)	4						AGCCCATCATGGATAGTCAAG	0.637		NA											23	57					2.89e-11	5.25e-11	1	0
PCLO	27445	broad.mit.edu	37	7	82451863	82451863	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:82451863C>A	uc003uhx.2	-	20	15028	c.14739G>T	c.(14737-14739)GGG>GGT	p.G4913G	PCLO_uc003uhv.2_Silent_p.G4913G|PCLO_uc003uht.1_Silent_p.G355G|PCLO_uc003uhu.1_Silent_p.G334G	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4775					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CTATGGCAGCCCCTGCATCTT	0.498		NA											71	176					3.31e-33	7e-33	1	0
ABCB1	5243	broad.mit.edu	37	7	87160614	87160614	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:87160614C>G	uc003uiz.1	-	22	3099	c.2681G>C	c.(2680-2682)GGG>GCG	p.G894A	ABCB1_uc011khc.1_Missense_Mutation_p.G830A	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	894	ABC transmembrane type-1 2.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	ACTCACCTTCCCAGAACCTTC	0.343		NA											23	36					0	0	0	0
PEX1	5189	broad.mit.edu	37	7	92134134	92134134	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:92134134C>A	uc003uly.2	-	12	2079	c.1983G>T	c.(1981-1983)CTG>CTT	p.L661L	PEX1_uc011khr.1_Silent_p.L453L|PEX1_uc010ley.2_Intron|PEX1_uc011khs.1_Silent_p.L339L|PEX1_uc011kht.1_RNA	NM_000466	NP_000457	O43933	PEX1_HUMAN	peroxin1	661			Missing (in NALD).		microtubule-based peroxisome localization|protein import into peroxisome matrix	cytosol|nucleus|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			ovary(1)|central_nervous_system(1)	2	all_cancers(62;9.35e-11)|all_epithelial(64;4.59e-10)|Breast(17;0.00201)|all_lung(186;0.0438)|Lung NSC(181;0.0592)	Breast(660;0.000932)|all_neural(109;0.00391)|Myeloproliferative disorder(862;0.0122)|Ovarian(593;0.023)|Medulloblastoma(109;0.123)	GBM - Glioblastoma multiforme(5;4.06e-06)|STAD - Stomach adenocarcinoma(4;4.51e-05)|all cancers(6;5.32e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			CAAGGTCATCCAGCAGGACAA	0.502		NA											30	84					3.58e-08	6.12e-08	1	0
PON1	5444	broad.mit.edu	37	7	94944746	94944746	+	Silent	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:94944746A>G	uc003uns.2	-	4	355	c.258T>C	c.(256-258)CTT>CTC	p.L86L	PON1_uc011kih.1_Silent_p.L86L	NM_000446	NP_000437	P27169	PON1_HUMAN	paraoxonase 1 precursor	86					aromatic compound catabolic process|carboxylic acid catabolic process|organophosphate catabolic process|phosphatidylcholine metabolic process|positive regulation of binding|positive regulation of cholesterol efflux|positive regulation of transporter activity|response to external stimulus	spherical high-density lipoprotein particle	aryldialkylphosphatase activity|arylesterase activity|calcium ion binding|phospholipid binding|protein homodimerization activity			pancreas(1)	1	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0031)		Atorvastatin(DB01076)|Cefazolin(DB01327)	GGTCCATCAGAAGTATTTTTC	0.388		NA											20	55					0	0	0	0
ZNF789	285989	broad.mit.edu	37	7	99084446	99084446	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:99084446G>C	uc003uqq.1	+	5	832	c.613G>C	c.(613-615)GAA>CAA	p.E205Q	ZNF789_uc010lfw.1_Missense_Mutation_p.E110Q|ZNF789_uc003uqr.1_Missense_Mutation_p.E147Q	NM_213603	NP_998768	Q5FWF6	ZN789_HUMAN	zinc finger protein 789 isoform 1	205	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					TGAATGCAGTGAATGTGGAAA	0.418		NA											34	55					0	0	0	0
ZNF394	84124	broad.mit.edu	37	7	99097390	99097390	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:99097390C>T	uc003uqs.2	-	1	488	c.327G>A	c.(325-327)CTG>CTA	p.L109L	ZNF394_uc003uqt.2_5'UTR|ZNF394_uc003uqu.1_Silent_p.L109L	NM_032164	NP_115540	Q53GI3	ZN394_HUMAN	zinc finger protein 394	109	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					GGAACTGCTCCAGCACCAGCA	0.672		NA											5	134					0	0	0	0
ZKSCAN5	23660	broad.mit.edu	37	7	99124011	99124011	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:99124011A>C	uc003uqv.2	+	6	1472	c.1348A>C	c.(1348-1350)AAA>CAA	p.K450Q	ZKSCAN5_uc010lfx.2_Missense_Mutation_p.K450Q|ZKSCAN5_uc003uqw.2_Missense_Mutation_p.K450Q|ZKSCAN5_uc003uqx.2_Missense_Mutation_p.K377Q|ZKSCAN5_uc003uqy.2_Missense_Mutation_p.K186Q	NM_145102	NP_659570	Q9Y2L8	ZKSC5_HUMAN	zinc finger with KRAB and SCAN domains 5	450	C2H2-type 4.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					CGAACACCTAAAACGCCACTT	0.502		NA											79	190					0	0	0	0
ZNF655	79027	broad.mit.edu	37	7	99170651	99170651	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:99170651G>C	uc003urh.2	+	3	1313	c.920G>C	c.(919-921)AGT>ACT	p.S307T	ZNF655_uc010lga.2_Missense_Mutation_p.S342T|ZNF655_uc010lgc.2_Missense_Mutation_p.S342T|ZNF655_uc003urj.2_Missense_Mutation_p.S307T|ZNF655_uc003urk.2_Missense_Mutation_p.S144T|ZNF655_uc010lgd.2_Missense_Mutation_p.S144T	NM_138494	NP_612503	Q8N720	ZN655_HUMAN	zinc finger protein 655 isoform a	307	C2H2-type 3.				G1 phase|regulation of mitotic cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding|zinc ion binding			ovary(1)	1	all_epithelial(64;3.19e-09)|Lung NSC(181;0.0066)|all_lung(186;0.011)|Esophageal squamous(72;0.0166)					AAATGTAGCAGTTGTGAAAGA	0.413		NA											20	52					0	0	0	0
TFR2	7036	broad.mit.edu	37	7	100225246	100225246	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:100225246A>T	uc003uvv.1	-	15	1762	c.1721T>A	c.(1720-1722)TTC>TAC	p.F574Y	TFR2_uc010lhc.1_Missense_Mutation_p.F115Y|TFR2_uc003uvu.1_Missense_Mutation_p.F403Y	NM_003227	NP_003218	Q9UP52	TFR2_HUMAN	transferrin receptor 2	574	Extracellular (Potential).				cellular iron ion homeostasis|iron ion transport|proteolysis	cytoplasm|integral to plasma membrane	peptidase activity|transferrin receptor activity			ovary(1)|pancreas(1)	2	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					AAAGGCCGTGAAGGAATAGGC	0.632		NA											9	39					0	0	0	0
MUC17	140453	broad.mit.edu	37	7	100676773	100676773	+	Silent	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:100676773T>C	uc003uxp.1	+	3	2129	c.2076T>C	c.(2074-2076)AGT>AGC	p.S692S	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	692	Extracellular (Potential).|9.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CATTAACAAGTATGCCTGTCA	0.493		NA											213	468					0	0	0	0
RELN	5649	broad.mit.edu	37	7	103292197	103292197	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:103292197C>G	uc003vca.2	-	15	1963	c.1803G>C	c.(1801-1803)TGG>TGC	p.W601C	RELN_uc010liz.2_Missense_Mutation_p.W601C	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	601	BNR 1.				axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		GAAGGAGGGACCAGGAGCGCC	0.478		NA											14	32					0	0	0	0
RINT1	60561	broad.mit.edu	37	7	105204333	105204334	+	Missense_Mutation	DNP	CG	CG	TA			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:105204333_105204334CG>TA	uc003vda.1	+	12	2056_2057	c.1825_1826CG>TA	c.(1825-1827)CGT>TAT	p.R609Y	RINT1_uc010ljj.1_Missense_Mutation_p.R184Y	NM_021930	NP_068749	Q6NUQ1	RINT1_HUMAN	RAD50 interactor 1	609	RINT1/TIP20.				cell cycle|G2/M transition DNA damage checkpoint|protein transport|vesicle-mediated transport	endoplasmic reticulum membrane	protein binding			ovary(3)|central_nervous_system(1)	4						TATGTTGACCCGTCAAGTAGAC	0.386		NA											12	43					0	0	0	0
LAMB4	22798	broad.mit.edu	37	7	107746424	107746424	+	Silent	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:107746424A>G	uc010ljo.1	-	8	792	c.708T>C	c.(706-708)CTT>CTC	p.L236L	LAMB4_uc003vey.2_Silent_p.L236L	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	236	Laminin N-terminal.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8						AAGCATCCCCAAGGGTGTGGA	0.418		NA											16	42					0	0	0	0
LRRN3	54674	broad.mit.edu	37	7	110762957	110762957	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:110762957C>A	uc003vft.3	+	4	1175	c.129C>A	c.(127-129)CCC>CCA	p.P43P	IMMP2L_uc003vfq.1_Intron|IMMP2L_uc010ljr.1_Intron|IMMP2L_uc003vfr.2_Intron|LRRN3_uc003vfu.3_Silent_p.P43P|LRRN3_uc003vfs.3_Silent_p.P43P	NM_001099660	NP_001093130	Q9H3W5	LRRN3_HUMAN	leucine rich repeat neuronal 3 precursor	43	Extracellular (Potential).|LRRNT.					integral to membrane				skin(3)|ovary(2)|pancreas(2)|central_nervous_system(1)	8				UCEC - Uterine corpus endometrioid carcinoma (4;0.245)|LUSC - Lung squamous cell carcinoma(290;0.0715)|Lung(3;0.0864)|STAD - Stomach adenocarcinoma(3;0.125)		GGTTTACACCCAGATCCATTT	0.413		NA											27	80					1.26e-06	2.08e-06	1	0
DOCK4	9732	broad.mit.edu	37	7	111540519	111540519	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:111540519C>A	uc003vfx.2	-	15	1660	c.1391G>T	c.(1390-1392)AGT>ATT	p.S464I	DOCK4_uc003vfy.2_Missense_Mutation_p.S464I|DOCK4_uc003vga.1_Missense_Mutation_p.S69I	NM_014705	NP_055520	Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	464	DHR-1.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(1;0.0441)				CCACCTGGGACTGTTGTTATG	0.488		NA											7	18					0.00621372	0.00888377	1	0
ASZ1	136991	broad.mit.edu	37	7	117023080	117023080	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:117023080A>T	uc003vjb.2	-	7	835	c.772T>A	c.(772-774)TTG>ATG	p.L258M	ASZ1_uc011kno.1_Missense_Mutation_p.L258M|ASZ1_uc011knp.1_Missense_Mutation_p.L50M	NM_130768	NP_570124	Q8WWH4	ASZ1_HUMAN	ankyrin repeat, SAM and basic leucine zipper	258					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	signal transducer activity			central_nervous_system(2)|ovary(1)	3	Lung NSC(10;0.00156)|all_lung(10;0.00175)		STAD - Stomach adenocarcinoma(10;0.000512)			TCTGTTGTCAATATTTTACAA	0.259		NA											12	46					0	0	0	0
CFTR	1080	broad.mit.edu	37	7	117246788	117246788	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:117246788C>A	uc003vjd.2	+	18	3101	c.2969C>A	c.(2968-2970)ACC>AAC	p.T990N	CFTR_uc011knq.1_Missense_Mutation_p.T396N	NM_000492	NP_000483	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance	990	Cytoplasmic (Potential).|ABC transmembrane type-1 2.				respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			central_nervous_system(2)|skin(2)|ovary(1)	5	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	CTGCCTCTTACCATATTTGAC	0.289		NA							Cystic_Fibrosis				23	89					3.29e-13	6.16e-13	1	0
HYAL4	23553	broad.mit.edu	37	7	123508735	123508735	+	Silent	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:123508735A>G	uc003vlc.2	+	3	1046	c.408A>G	c.(406-408)GAA>GAG	p.E136E	HYAL4_uc011knz.1_Silent_p.E136E	NM_012269	NP_036401	Q2M3T9	HYAL4_HUMAN	hyaluronoglucosaminidase 4	136	Extracellular (Potential).				fusion of sperm to egg plasma membrane|glycosaminoglycan catabolic process	integral to membrane	hyalurononglucosaminidase activity			skin(1)	1						TCCCTGCTGAAGATTTCAGTG	0.428		NA											19	63					0	0	0	0
GCC1	79571	broad.mit.edu	37	7	127223058	127223058	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:127223058C>T	uc003vma.2	-	2	1756	c.1338G>A	c.(1336-1338)GCG>GCA	p.A446A		NM_024523	NP_078799	Q96CN9	GCC1_HUMAN	Golgi coiled-coil protein 1	446	Potential.					Golgi membrane|plasma membrane	protein binding			ovary(2)	2						TTTTCCTGGCCGCAACCTGCA	0.557		NA											45	132					0	0	0	0
DGKI	9162	broad.mit.edu	37	7	137237200	137237200	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:137237200G>T	uc003vtt.2	-	20	2063	c.2062C>A	c.(2062-2064)CCA>ACA	p.P688T	DGKI_uc003vtu.2_Missense_Mutation_p.P388T	NM_004717	NP_004708	O75912	DGKI_HUMAN	diacylglycerol kinase, iota	688					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3						ATCATAGCTGGGGCCAACCTA	0.517		NA											40	98					6.05e-29	1.27e-28	1	0
DGKI	9162	broad.mit.edu	37	7	137271843	137271843	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:137271843C>A	uc003vtt.2	-	13	1426	c.1425G>T	c.(1423-1425)GGG>GGT	p.G475G	DGKI_uc003vtu.2_Silent_p.G175G	NM_004717	NP_004708	O75912	DGKI_HUMAN	diacylglycerol kinase, iota	475	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3						CAGTTCTTACCCCTCCCCAGT	0.552		NA											18	54					5.39e-06	8.68e-06	1	0
PARP12	64761	broad.mit.edu	37	7	139756947	139756947	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:139756947G>A	uc003vvl.1	-	3	1343	c.469C>T	c.(469-471)CAA>TAA	p.Q157*	PARP12_uc003vvk.1_5'UTR|PARP12_uc010lnf.1_RNA	NM_022750	NP_073587	Q9H0J9	PAR12_HUMAN	poly ADP-ribose polymerase 12	157	C3H1-type 2.					nucleus	NAD+ ADP-ribosyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)	3	Melanoma(164;0.0142)					TTGTAATGTTGGCAAATCTGT	0.498		NA											30	76					0	0	0	0
DENND2A	27147	broad.mit.edu	37	7	140244499	140244499	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:140244499G>C	uc010lnj.2	-	12	2391	c.2246C>G	c.(2245-2247)TCC>TGC	p.S749C	DENND2A_uc011kre.1_RNA|DENND2A_uc010lnk.2_Missense_Mutation_p.S749C|DENND2A_uc003vvw.2_Missense_Mutation_p.S749C|DENND2A_uc003vvx.2_Missense_Mutation_p.S749C	NM_015689	NP_056504	Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	749	DENN.									ovary(3)|breast(1)	4	Melanoma(164;0.00956)					GACGCTGAGGGAGGAGAAGAG	0.602		NA											8	25					0	0	0	0
TAS2R38	5726	broad.mit.edu	37	7	141673292	141673292	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:141673292G>T	uc003vwx.1	-	1	282	c.198C>A	c.(196-198)TTC>TTA	p.F66L		NM_176817	NP_789787	P59533	T2R38_HUMAN	taste receptor, type 2, member 38	66	Helical; Name=2; (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			kidney(1)|skin(1)	2	Melanoma(164;0.0171)					GTCCATGCAGGAAAAGCCGGC	0.493		NA											37	85					2.42e-17	4.8e-17	1	0
TAS2R40	259286	broad.mit.edu	37	7	142919319	142919319	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:142919319G>C	uc011ksx.1	+	1	148	c.148G>C	c.(148-150)GGC>CGC	p.G50R		NM_176882	NP_795363	P59535	T2R40_HUMAN	taste receptor, type 2, member 40	50	Cytoplasmic (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			ovary(1)	1	Melanoma(164;0.059)					GTGGGCCAGGGGCAAAACACT	0.522		NA											23	66					0	0	0	0
OR2F1	26211	broad.mit.edu	37	7	143657134	143657134	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:143657134G>T	uc003wds.1	+	1	115	c.71G>T	c.(70-72)CGG>CTG	p.R24L		NM_012369	NP_036501	Q13607	OR2F1_HUMAN	olfactory receptor, family 2, subfamily F,	24	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	Melanoma(164;0.0903)					TGGGACACTCGGGTCTCCCTG	0.473		NA											80	142					1.46e-39	3.11e-39	1	0
OR2A5	393046	broad.mit.edu	37	7	143747689	143747689	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:143747689G>T	uc011ktw.1	+	1	195	c.195G>T	c.(193-195)CTG>CTT	p.L65L		NM_012365	NP_036497	Q96R48	OR2A5_HUMAN	olfactory receptor, family 2, subfamily A,	65	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3	Melanoma(164;0.0783)					TCTCACACCTGGCCATCATTG	0.488		NA											18	77					3.53e-06	5.7e-06	1	0
OR2A12	346525	broad.mit.edu	37	7	143793100	143793100	+	Silent	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:143793100A>G	uc011kty.1	+	1	900	c.900A>G	c.(898-900)CTA>CTG	p.L300L		NM_001004135	NP_001004135	Q8NGT7	O2A12_HUMAN	olfactory receptor, family 2, subfamily A,	300	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3	Melanoma(164;0.0783)					AAGGGGCTCTAAAGAGAGTCC	0.453		NA											68	186					0	0	0	0
OR2A14	135941	broad.mit.edu	37	7	143826284	143826284	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:143826284T>C	uc011kua.1	+	1	79	c.79T>C	c.(79-81)TGT>CGT	p.C27R		NM_001001659	NP_001001659	Q96R47	O2A14_HUMAN	olfactory receptor, family 2, subfamily A,	27	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Melanoma(164;0.0783)					GATTCTCCTCTGTGGACTTTT	0.502		NA											28	80					0	0	0	0
ZNF467	168544	broad.mit.edu	37	7	149462862	149462862	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:149462862G>A	uc003wgd.2	-	5	870	c.729C>T	c.(727-729)CCC>CCT	p.P243P	ZNF467_uc003wgc.2_Intron	NM_207336	NP_997219	Q7Z7K2	ZN467_HUMAN	zinc finger protein 467	243					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CGCACGGGTAGGGCCGCTCGC	0.687		NA											12	20					0	0	0	0
GALNTL5	168391	broad.mit.edu	37	7	151711783	151711783	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:151711783A>G	uc003wkp.2	+	8	1304	c.1081A>G	c.(1081-1083)ATC>GTC	p.I361V	GALNTL5_uc003wkq.2_Missense_Mutation_p.I112V|GALNTL5_uc003wkr.2_RNA|GALNTL5_uc003wks.2_RNA|GALNTL5_uc010lqf.2_Missense_Mutation_p.I250V	NM_145292	NP_660335	Q7Z4T8	GLTL5_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	361	Catalytic subdomain B.|Lumenal (Potential).					Golgi membrane|integral to membrane	transferase activity, transferring glycosyl groups			ovary(2)	2	all_neural(206;0.187)	all_hematologic(28;0.0749)	OV - Ovarian serous cystadenocarcinoma(82;0.00427)	UCEC - Uterine corpus endometrioid carcinoma (81;0.18)|BRCA - Breast invasive adenocarcinoma(188;0.166)		AGTAGGACATATCAGTAAGAA	0.408		NA											22	57					0	0	0	0
PTPRN2	5799	broad.mit.edu	37	7	157364177	157364177	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr7:157364177T>C	uc003wno.2	-	20	2913	c.2792A>G	c.(2791-2793)AAC>AGC	p.N931S	PTPRN2_uc003wnp.2_Missense_Mutation_p.N914S|PTPRN2_uc003wnq.2_Missense_Mutation_p.N902S|PTPRN2_uc003wnr.2_Missense_Mutation_p.N893S|PTPRN2_uc011kwa.1_Missense_Mutation_p.N954S|PTPRN2_uc003wnn.2_5'Flank	NM_002847	NP_002838	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N	931	Cytoplasmic (Potential).|Tyrosine-protein phosphatase.					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|large_intestine(1)|pleura(1)|skin(1)	7	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		GTAGCACTTGTTTACTTTTCT	0.338		NA											21	63					0	0	0	0
SGK223	157285	broad.mit.edu	37	8	8185684	8185684	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:8185684G>A	uc003wsh.3	-	4	2608	c.2608C>T	c.(2608-2610)CAC>TAC	p.H870Y		NM_001080826	NP_001074295	Q86YV5	SG223_HUMAN	pragmin	870							ATP binding|non-membrane spanning protein tyrosine kinase activity				0						ACAGGATGGTGGCGGTTCCCG	0.592		NA											91	239					0	0	0	0
MFHAS1	9258	broad.mit.edu	37	8	8750112	8750112	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:8750112G>C	uc003wsj.1	-	1	1020	c.457C>G	c.(457-459)CAG>GAG	p.Q153E		NM_004225	NP_004216	Q9Y4C4	MFHA1_HUMAN	malignant fibrous histiocytoma amplified	153	LRR 4.										0		Hepatocellular(245;0.217)		COAD - Colon adenocarcinoma(149;0.124)		GCGCCCAGCTGGGCGGGCAGG	0.692		NA											6	13					0	0	0	0
TNKS	8658	broad.mit.edu	37	8	9609323	9609323	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:9609323G>T	uc003wss.2	+	19	3042	c.3037G>T	c.(3037-3039)GGC>TGC	p.G1013C	TNKS_uc011kww.1_Missense_Mutation_p.G776C|TNKS_uc010lrt.1_RNA	NM_003747	NP_003738	O95271	TNKS1_HUMAN	tankyrase, TRF1-interacting ankyrin-related	1013					mitotic spindle organization|mRNA transport|negative regulation of DNA binding|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of telomere maintenance via telomerase|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein poly-ADP-ribosylation|protein polyubiquitination|protein transport|spindle assembly|transmembrane transport|Wnt receptor signaling pathway	chromosome, centromeric region|Golgi membrane|microsome|nuclear chromosome, telomeric region|nuclear membrane|nuclear pore|pericentriolar material	NAD+ ADP-ribosyltransferase activity|protein binding|zinc ion binding			lung(4)|ovary(2)|kidney(1)	7				COAD - Colon adenocarcinoma(149;0.0467)		TGCAGGGGATGGCGCCGCGGG	0.522		NA											39	101					5.45e-19	1.1e-18	1	0
RP1L1	94137	broad.mit.edu	37	8	10470038	10470038	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:10470038T>A	uc003wtc.2	-	4	1799	c.1570A>T	c.(1570-1572)AGG>TGG	p.R524W		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	524					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		CTCCGGGCCCTCGGTGTCAGG	0.697		NA											22	67					0	0	0	0
SGCZ	137868	broad.mit.edu	37	8	13959967	13959967	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:13959967C>A	uc003wwq.2	-	7	1322	c.662G>T	c.(661-663)CGT>CTT	p.R221L	SGCZ_uc010lss.2_Missense_Mutation_p.R174L	NM_139167	NP_631906	Q96LD1	SGCZ_HUMAN	sarcoglycan zeta	208	Extracellular (Potential).				cytoskeleton organization	cytoplasm|cytoskeleton|integral to membrane|sarcolemma				ovary(2)|central_nervous_system(1)	3				all cancers(2;0.000643)|Colorectal(111;0.00674)|COAD - Colon adenocarcinoma(73;0.0193)|GBM - Glioblastoma multiforme(2;0.026)		CTGGACCCCACGGGGAGCTTC	0.458		NA											16	44					2.32e-05	3.65e-05	1	0
ATP6V1B2	526	broad.mit.edu	37	8	20075667	20075667	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:20075667G>A	uc003wzp.2	+	13	1484	c.1270G>A	c.(1270-1272)GCG>ACG	p.A424T	ATP6V1B2_uc003wzq.1_5'Flank	NM_001693	NP_001684	P21281	VATB2_HUMAN	vacuolar H+ATPase B2	424				AC -> RA (in Ref. 7; AAA35610).	ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|endomembrane system|Golgi apparatus|melanosome|plasma membrane|proton-transporting V-type ATPase, V1 domain	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism				0				Colorectal(74;0.0535)|COAD - Colon adenocarcinoma(73;0.211)		TCTTTAGTATGCGTGCTATGC	0.438		NA											36	84					0	0	0	0
GFRA2	2675	broad.mit.edu	37	8	21560483	21560483	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:21560483G>C	uc003wzu.1	-	7	1727	c.1052C>G	c.(1051-1053)GCC>GGC	p.A351G	GFRA2_uc003wzv.1_Missense_Mutation_p.A246G|GFRA2_uc003wzw.1_Missense_Mutation_p.A218G	NM_001495	NP_001486	O00451	GFRA2_HUMAN	GDNF family receptor alpha 2 isoform a	351						anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity				0				Colorectal(74;0.0189)|COAD - Colon adenocarcinoma(73;0.0727)		GGCCTGGATGGCGTTCCCTGG	0.632		NA											5	11					0	0	0	0
PEBP4	157310	broad.mit.edu	37	8	22675246	22675246	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:22675246G>T	uc003xcn.1	-	4	353	c.261C>A	c.(259-261)GGC>GGA	p.G87G		NM_144962	NP_659399	Q96S96	PEBP4_HUMAN	phosphatidylethanolamine-binding protein 4	87						lysosome				ovary(1)|large_intestine(1)|breast(1)|skin(1)	4		Prostate(55;0.0453)|Breast(100;0.103)		Colorectal(74;0.0434)|COAD - Colon adenocarcinoma(73;0.124)		TATAGGTTGCGCCCTGTAACA	0.493		NA											29	56					5.46e-16	1.07e-15	1	0
EBF2	64641	broad.mit.edu	37	8	25715905	25715905	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:25715905G>T	uc003xes.1	-	14	1475	c.1458C>A	c.(1456-1458)CCC>CCA	p.P486P	PPP2R2A_uc003xek.2_Intron|EBF2_uc010lug.1_RNA	NM_022659	NP_073150	Q9HAK2	COE2_HUMAN	early B-cell factor 2	486	Pro/Ser/Thr-rich.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding			ovary(3)|skin(1)	4		all_cancers(63;0.0989)|Ovarian(32;2.74e-05)|all_epithelial(46;0.0608)|Prostate(55;0.0845)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0277)|Epithelial(17;3.29e-10)|Colorectal(74;0.00383)|COAD - Colon adenocarcinoma(73;0.00738)		AGTTGGCCATGGGGACATTGC	0.522		NA											32	59					2.85e-18	5.71e-18	1	0
PTK2B	2185	broad.mit.edu	37	8	27295006	27295006	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:27295006A>G	uc003xfn.1	+	22	2328	c.1520A>G	c.(1519-1521)TAT>TGT	p.Y507C	PTK2B_uc003xfo.1_Missense_Mutation_p.Y507C|PTK2B_uc003xfp.1_Missense_Mutation_p.Y507C|PTK2B_uc003xfq.1_Missense_Mutation_p.Y507C|PTK2B_uc003xfr.1_Missense_Mutation_p.Y253C	NM_173174	NP_775266	Q14289	FAK2_HUMAN	PTK2B protein tyrosine kinase 2 beta isoform a	507	Protein kinase.				apoptosis|bone resorption|positive regulation of cell proliferation|signal complex assembly	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|signal transducer activity			lung(3)|ovary(1)|skin(1)	5		Ovarian(32;2.72e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|Epithelial(17;6.61e-10)|BRCA - Breast invasive adenocarcinoma(99;0.226)|Colorectal(74;0.229)		TTGTATCCCTATGGGGAGGTG	0.552		NA											12	29					0	0	0	0
UNC5D	137970	broad.mit.edu	37	8	35406972	35406972	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:35406972G>T	uc003xjr.1	+	2	594	c.266G>T	c.(265-267)GGC>GTC	p.G89V	UNC5D_uc003xjs.1_Missense_Mutation_p.G84V	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	89	Extracellular (Potential).|Ig-like.				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		AAATGCAACGGCGAGTGGGTC	0.507		NA											17	29					5.01e-05	7.78e-05	1	0
EIF4EBP1	1978	broad.mit.edu	37	8	37914654	37914654	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:37914654G>T	uc003xks.2	+	2	273	c.201G>T	c.(199-201)GTG>GTT	p.V67V		NM_004095	NP_004086	Q13541	4EBP1_HUMAN	eukaryotic translation initiation factor 4E	67					G1/S transition of mitotic cell cycle|insulin receptor signaling pathway|positive regulation of mitotic cell cycle|TOR signaling cascade|translation	cytosol					0	Colorectal(12;0.00627)	Lung NSC(58;0.118)|all_lung(54;0.195)				ACTCACCTGTGACCAAAACAC	0.572		NA											21	81					2.71e-06	4.39e-06	1	0
TM2D2	83877	broad.mit.edu	37	8	38853858	38853858	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:38853858T>C	uc003xmk.2	-	1	184	c.101A>G	c.(100-102)CAC>CGC	p.H34R	ADAM9_uc011lcf.1_5'Flank|ADAM9_uc003xmr.2_5'Flank|ADAM9_uc011lcg.1_5'Flank|ADAM9_uc010lwr.2_5'Flank|TM2D2_uc003xml.2_5'UTR|TM2D2_uc003xmm.2_Intron|TM2D2_uc003xmn.2_Intron|ADAM9_uc003xmo.1_5'Flank|ADAM9_uc003xmp.2_5'Flank	NM_078473	NP_510882	Q9BX73	TM2D2_HUMAN	TM2 domain containing 2 isoform a	34						integral to membrane					0		all_lung(54;0.00338)|Lung NSC(58;0.0133)|Hepatocellular(245;0.0153)	LUSC - Lung squamous cell carcinoma(45;1.5e-07)			ATTTTGCGAGTGGCTCCGAGA	0.627		NA											40	82					0	0	0	0
PRKDC	5591	broad.mit.edu	37	8	48746771	48746771	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:48746771T>C	uc003xqi.2	-	60	8195	c.8138A>G	c.(8137-8139)GAT>GGT	p.D2713G	PRKDC_uc003xqj.2_Missense_Mutation_p.D2713G|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	2713	KIP-binding.				cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				CACTTTGTTATCCACCTCGTC	0.488		NA						NHEJ					115	238					0	0	0	0
PXDNL	137902	broad.mit.edu	37	8	52384809	52384809	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:52384809G>T	uc003xqu.3	-	8	851	c.750C>A	c.(748-750)ACC>ACA	p.T250T		NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	250	Ig-like C2-type 1.				hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				TGAAGTAGACGGTATTTCCTG	0.428		NA											35	93					1.67e-13	3.15e-13	1	0
RP1	6101	broad.mit.edu	37	8	55537480	55537480	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:55537480C>T	uc003xsd.1	+	4	1186	c.1038C>T	c.(1036-1038)ACC>ACT	p.T346T	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	346					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			AGGAAGAAACCATAAAATGGA	0.343		NA											9	20					0	0	0	0
XKR4	114786	broad.mit.edu	37	8	56436507	56436507	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:56436507C>A	uc003xsf.2	+	3	1706	c.1674C>A	c.(1672-1674)GAC>GAA	p.D558E		NM_052898	NP_443130	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related	558						integral to membrane				pancreas(2)	2			Epithelial(17;0.000117)|all cancers(17;0.000836)			TTGTCAGCGACCGCGATCAGA	0.592		NA											19	56					5.35e-07	8.9e-07	1	0
ASPH	444	broad.mit.edu	37	8	62566183	62566183	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:62566183G>A	uc003xuj.2	-	4	628	c.359C>T	c.(358-360)CCG>CTG	p.P120L	ASPH_uc011leg.1_Missense_Mutation_p.P91L|ASPH_uc003xuo.2_Missense_Mutation_p.P120L|ASPH_uc011leh.1_Missense_Mutation_p.P106L|ASPH_uc003xul.2_Missense_Mutation_p.P106L|ASPH_uc011lei.1_Missense_Mutation_p.P106L|ASPH_uc011lej.1_Missense_Mutation_p.P106L|ASPH_uc003xun.2_Missense_Mutation_p.P120L|ASPH_uc011lek.1_Missense_Mutation_p.P120L|ASPH_uc003xum.2_Missense_Mutation_p.P120L	NM_004318	NP_004309	Q12797	ASPH_HUMAN	aspartate beta-hydroxylase isoform a	120	Glu-rich.|Lumenal (Potential).				muscle contraction	integral to endoplasmic reticulum membrane	calcium ion binding|electron carrier activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity|structural constituent of muscle			ovary(3)	3	Lung SC(2;0.153)	Lung NSC(129;0.0358)|all_lung(136;0.0654)|all_epithelial(80;0.101)			L-Aspartic Acid(DB00128)|Succinic acid(DB00139)	CTCTTCTGGCGGGACTGCTGG	0.502		NA											7	30					0	0	0	0
MTFR1	9650	broad.mit.edu	37	8	66605983	66605983	+	Silent	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:66605983A>T	uc003xvm.2	+	4	482	c.270A>T	c.(268-270)TCA>TCT	p.S90S	MTFR1_uc011lep.1_Silent_p.S90S|MTFR1_uc003xvn.2_Silent_p.S57S|MTFR1_uc003xvo.1_Silent_p.S80S	NM_014637	NP_055452	Q15390	MTFR1_HUMAN	mitochondrial fission regulator 1 isoform 1	90						mitochondrion|plasma membrane				pancreas(1)	1			Epithelial(68;0.0526)|BRCA - Breast invasive adenocarcinoma(89;0.156)|all cancers(69;0.171)|OV - Ovarian serous cystadenocarcinoma(28;0.194)			GAGAGTGTTCAGCAAGACTAA	0.408		NA											16	25					0	0	0	0
PREX2	80243	broad.mit.edu	37	8	69002942	69002942	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:69002942C>A	uc003xxv.1	+	20	2269	c.2242C>A	c.(2242-2244)CCA>ACA	p.P748T	PREX2_uc003xxu.1_Missense_Mutation_p.P748T|PREX2_uc011lez.1_Missense_Mutation_p.P683T	NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	748	PDZ 2.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						GTACAGGCGGCCAACGAAGGT	0.483		NA											11	45					3.86e-05	6e-05	1	0
SULF1	23213	broad.mit.edu	37	8	70476335	70476335	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:70476335G>C	uc010lza.1	+	5	842	c.125G>C	c.(124-126)CGA>CCA	p.R42P	SULF1_uc003xyd.2_Missense_Mutation_p.R42P|SULF1_uc003xye.2_Missense_Mutation_p.R42P|SULF1_uc003xyf.2_Missense_Mutation_p.R42P|SULF1_uc003xyg.2_Missense_Mutation_p.R42P	NM_015170	NP_055985	Q8IWU6	SULF1_HUMAN	sulfatase 1 precursor	42					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			central_nervous_system(3)|ovary(2)|pancreas(1)|skin(1)	7	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			AAAAACATCCGACCCAACATT	0.483		NA											28	70					0	0	0	0
CRISPLD1	83690	broad.mit.edu	37	8	75929588	75929588	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:75929588G>C	uc003yan.2	+	10	1405	c.1030G>C	c.(1030-1032)GGT>CGT	p.G344R	CRISPLD1_uc011lfk.1_Missense_Mutation_p.G156R|CRISPLD1_uc011lfl.1_Missense_Mutation_p.G156R	NM_031461	NP_113649	Q9H336	CRLD1_HUMAN	cysteine-rich secretory protein LCCL domain	344	LCCL 1.					extracellular region				ovary(1)|central_nervous_system(1)	2	Breast(64;0.0799)		Epithelial(68;0.155)|BRCA - Breast invasive adenocarcinoma(89;0.161)			AATTCATTATGGTATAATAGA	0.343		NA											44	62					0	0	0	0
ZFHX4	79776	broad.mit.edu	37	8	77765155	77765155	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:77765155C>A	uc003yav.2	+	10	6250	c.5863C>A	c.(5863-5865)CCA>ACA	p.P1955T	ZFHX4_uc003yau.1_Missense_Mutation_p.P2000T|ZFHX4_uc003yaw.1_Missense_Mutation_p.P1955T	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1955	Pro-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TCCATCTTCTCCAGAAACGcc	0.308		NA								HNSCC(33;0.089)			8	18					0.000157383	0.000239122	1	0
ZFHX4	79776	broad.mit.edu	37	8	77775784	77775784	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:77775784C>A	uc003yav.2	+	11	10086	c.9699C>A	c.(9697-9699)CTC>CTA	p.L3233L		NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	3229						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CACCTCAGCTCCCTGGAACAG	0.517		NA								HNSCC(33;0.089)			35	100					2.2e-14	4.22e-14	1	0
ZNF704	619279	broad.mit.edu	37	8	81605276	81605276	+	Silent	SNP	A	A	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:81605276A>C	uc003yby.1	-	3	520	c.288T>G	c.(286-288)ACT>ACG	p.T96T		NM_001033723	NP_001028895	Q6ZNC4	ZN704_HUMAN	zinc finger protein 704	96						intracellular	zinc ion binding				0	all_cancers(3;8.53e-08)|all_epithelial(4;4.59e-10)|Breast(3;2.56e-06)|Lung NSC(7;2.58e-06)|all_lung(9;9.4e-06)		BRCA - Breast invasive adenocarcinoma(6;0.00401)|Epithelial(68;0.00448)|all cancers(69;0.0277)			CCAAAGGGCTAGTCGACAAGC	0.512		NA											15	41					0	0	0	0
ATP6V0D2	245972	broad.mit.edu	37	8	87165148	87165148	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:87165148C>A	uc003ydp.1	+	8	1064	c.995C>A	c.(994-996)GCA>GAA	p.A332E		NM_152565	NP_689778	Q8N8Y2	VA0D2_HUMAN	ATPase, H+ transporting, lysosomal 38kDa, V0	332					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	apical plasma membrane|endosome membrane|proton-transporting V-type ATPase, V0 domain|vacuolar proton-transporting V-type ATPase complex	hydrogen ion transmembrane transporter activity|protein binding				0						GTGTGGATAGCAGAATGTATT	0.333		NA											15	40					1.5e-05	2.37e-05	1	0
DCAF4L2	138009	broad.mit.edu	37	8	88885723	88885723	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:88885723G>T	uc003ydz.2	-	1	574	c.477C>A	c.(475-477)CTC>CTA	p.L159L		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	159										ovary(1)	1						GCGACGCTGGGAGCAGCACGG	0.562		NA											26	61					1.38e-21	2.82e-21	1	0
NECAB1	64168	broad.mit.edu	37	8	91929810	91929810	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:91929810C>A	uc011lgg.1	+	6	642	c.448C>A	c.(448-450)CTG>ATG	p.L150M		NM_022351	NP_071746	Q8N987	NECA1_HUMAN	N-terminal EF-hand calcium binding protein 1	150	Potential.				antibiotic biosynthetic process	cytoplasm	calcium ion binding|oxidoreductase activity			central_nervous_system(1)	1			BRCA - Breast invasive adenocarcinoma(11;0.0499)			CCAGAATTCCCTGGAATGTGC	0.403		NA											19	33					0.00152264	0.002239	1	0
CDH17	1015	broad.mit.edu	37	8	95161033	95161033	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:95161033C>T	uc003ygh.2	-	14	1991	c.1866G>A	c.(1864-1866)GTG>GTA	p.V622V	CDH17_uc011lgo.1_Silent_p.V408V|CDH17_uc011lgp.1_Silent_p.V622V	NM_004063	NP_004054	Q12864	CAD17_HUMAN	cadherin 17 precursor	622	Cadherin 6.|Extracellular (Potential).					integral to membrane	calcium ion binding			ovary(5)|skin(1)	6	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)			CCAATGGAGCCACACTAAAGA	0.413		NA											8	19					0	0	0	0
KIAA1429	25962	broad.mit.edu	37	8	95543280	95543280	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:95543280C>A	uc003ygo.1	-	6	531	c.518G>T	c.(517-519)AGC>ATC	p.S173I	KIAA1429_uc003ygp.2_Missense_Mutation_p.S173I	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	173	Pro-rich.				mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			TCTTGGAGGGCTTCCATTAAA	0.393		NA											11	46					1.09e-07	1.83e-07	1	0
MTDH	92140	broad.mit.edu	37	8	98731417	98731417	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:98731417G>T	uc003yhz.2	+	10	1849	c.1521G>T	c.(1519-1521)CAG>CAT	p.Q507H	MTDH_uc010mbf.2_RNA	NM_178812	NP_848927	Q86UE4	LYRIC_HUMAN	metadherin	507	Cytoplasmic (Potential).				lipopolysaccharide-mediated signaling pathway|negative regulation of apoptosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of angiogenesis|positive regulation of autophagy|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein kinase B signaling cascade	apical plasma membrane|endoplasmic reticulum membrane|integral to membrane|intercellular canaliculus|nuclear body|nuclear membrane|nucleolus|perinuclear region of cytoplasm|tight junction	NF-kappaB binding|RNA polymerase II transcription factor binding|transcription coactivator activity			liver(1)|central_nervous_system(1)	2	Breast(36;2.56e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.178)			AAAATAGCCAGGTAATTTTTA	0.229		NA											24	54					1.55e-18	3.12e-18	1	0
GRHL2	79977	broad.mit.edu	37	8	102656368	102656369	+	Missense_Mutation	DNP	CC	CC	GT			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:102656368_102656369CC>GT	uc010mbu.2	+	13	1857_1858	c.1527_1528CC>GT	c.(1525-1530)GTCCTT>GTGTTT	p.L510F		NM_024915	NP_079191	Q6ISB3	GRHL2_HUMAN	transcription factor CP2-like 3	510						cytoplasm|nucleus	DNA binding			ovary(2)|skin(1)	3	all_cancers(14;4.39e-08)|all_epithelial(15;4.09e-10)|Lung NSC(17;7.11e-06)|all_lung(17;1.44e-05)		Epithelial(11;5.81e-09)|all cancers(13;3.81e-07)|OV - Ovarian serous cystadenocarcinoma(57;0.000213)			GTGGCAGTGTCCTTGTTAAACG	0.465		NA											8	25					0	0	0	0
ATP6V1C1	528	broad.mit.edu	37	8	104068161	104068161	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:104068161G>A	uc003ykz.3	+	8	883	c.638G>A	c.(637-639)AGC>AAC	p.S213N	ATP6V1C1_uc010mbz.2_Missense_Mutation_p.S138N|ATP6V1C1_uc003yla.2_Missense_Mutation_p.S213N|ATP6V1C1_uc011lhl.1_Missense_Mutation_p.S138N	NM_001695	NP_001686	P21283	VATC1_HUMAN	ATPase, H+ transporting, lysosomal V1 subunit	213					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|plasma membrane|proton-transporting V-type ATPase, V1 domain	protein binding|proton-transporting ATPase activity, rotational mechanism				0	Lung NSC(17;0.000427)|all_lung(17;0.000533)		OV - Ovarian serous cystadenocarcinoma(57;3.57e-05)|STAD - Stomach adenocarcinoma(118;0.133)			CCAAGGTCTAGCAAGTAAGTA	0.373		NA											9	30					0	0	0	0
RIMS2	9699	broad.mit.edu	37	8	104898151	104898151	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:104898151C>G	uc003yls.2	+	2	899	c.658C>G	c.(658-660)CCC>GCC	p.P220A	RIMS2_uc003ylp.2_Missense_Mutation_p.P442A|RIMS2_uc003ylw.2_Missense_Mutation_p.P250A|RIMS2_uc003ylq.2_Missense_Mutation_p.P250A|RIMS2_uc003ylr.2_Missense_Mutation_p.P250A	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	473					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			GAGTCCACTACCCATAGATAG	0.463		NA								HNSCC(12;0.0054)			10	44					0	0	0	0
RIMS2	9699	broad.mit.edu	37	8	105027684	105027684	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:105027684G>A	uc003yls.2	+	18	2828	c.2587G>A	c.(2587-2589)GAA>AAA	p.E863K	RIMS2_uc003ylp.2_Intron|RIMS2_uc003ylw.2_Missense_Mutation_p.E937K|RIMS2_uc003ylq.2_Intron|RIMS2_uc003ylr.2_Intron	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			ACCTTATGAAGGTCTGTACAT	0.323		NA								HNSCC(12;0.0054)			4	5					0	0	0	0
KCNV1	27012	broad.mit.edu	37	8	110980754	110980754	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:110980754C>A	uc003ynr.3	-	3	1408	c.1066G>T	c.(1066-1068)GGA>TGA	p.G356*	KCNV1_uc010mcw.2_Nonsense_Mutation_p.G356*	NM_014379	NP_055194	Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	356	Helical; Name=Segment S5; (Potential).					voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			lung(1)|kidney(1)	2	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			ATAGAGATTCCCACGGATAGA	0.478		NA											35	53					2.81e-11	5.1e-11	1	0
CSMD3	114788	broad.mit.edu	37	8	113246700	113246700	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:113246700T>C	uc003ynu.2	-	68	10793	c.10634A>G	c.(10633-10635)TAT>TGT	p.Y3545C	CSMD3_uc003yns.2_Missense_Mutation_p.Y2747C|CSMD3_uc003ynt.2_Missense_Mutation_p.Y3505C|CSMD3_uc011lhx.1_Missense_Mutation_p.Y3376C	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3545	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CTGGCTTTTATATACCCCTGT	0.313		NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			36	82					0	0	0	0
CSMD3	114788	broad.mit.edu	37	8	113256746	113256746	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:113256746G>T	uc003ynu.2	-	65	10438	c.10279C>A	c.(10279-10281)CTT>ATT	p.L3427I	CSMD3_uc003yns.2_Missense_Mutation_p.L2629I|CSMD3_uc003ynt.2_Missense_Mutation_p.L3387I|CSMD3_uc011lhx.1_Missense_Mutation_p.L3258I	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3427	Extracellular (Potential).|Sushi 28.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TGAGATGGAAGGTCCATCCCT	0.418		NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			14	50					0.000308642	0.000462515	1	0
CSMD3	114788	broad.mit.edu	37	8	113418923	113418923	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:113418923G>A	uc003ynu.2	-	35	5798	c.5639C>T	c.(5638-5640)TCT>TTT	p.S1880F	CSMD3_uc003yns.2_Missense_Mutation_p.S1082F|CSMD3_uc003ynt.2_Missense_Mutation_p.S1840F|CSMD3_uc011lhx.1_Missense_Mutation_p.S1776F	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1880	Sushi 10.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TTCAGGCACAGAACTGCATTG	0.338		NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			22	48					0	0	0	0
ADCY8	114	broad.mit.edu	37	8	131861992	131861992	+	Silent	SNP	G	G	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:131861992G>C	uc003ytd.3	-	10	2524	c.2268C>G	c.(2266-2268)GTC>GTG	p.V756V	ADCY8_uc010mds.2_Intron	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	756	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			TGGTGATGAGGACCAGAGCCG	0.473		NA								HNSCC(32;0.087)			3	11					0	0	0	0
PHF20L1	51105	broad.mit.edu	37	8	133816972	133816972	+	Silent	SNP	T	T	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:133816972T>G	uc003ytt.2	+	8	1159	c.834T>G	c.(832-834)CTT>CTG	p.L278L	PHF20L1_uc003ytr.2_Silent_p.L252L|PHF20L1_uc010mdv.2_Silent_p.L252L|PHF20L1_uc003yts.2_Silent_p.L278L|PHF20L1_uc011lja.1_Silent_p.L252L|PHF20L1_uc003ytu.1_RNA|PHF20L1_uc003ytv.2_Silent_p.L117L	NM_016018	NP_057102	A8MW92	P20L1_HUMAN	PHD finger protein 20-like 1 isoform 1	278							nucleic acid binding|zinc ion binding			ovary(2)	2	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			GAGCTCGACTTAACAAGATTA	0.343		NA											20	52					0	0	0	0
TG	7038	broad.mit.edu	37	8	133899673	133899673	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:133899673G>T	uc003ytw.2	+	9	2097	c.2056G>T	c.(2056-2058)GCT>TCT	p.A686S		NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	686	Thyroglobulin type-1 6.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GTTTGTCCCTGCTTGTACTAG	0.557		NA											21	46					1.02e-10	1.84e-10	1	0
SLA	6503	broad.mit.edu	37	8	134050883	134050883	+	Silent	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:134050883C>A	uc003ytz.2	-	9	1549	c.717G>T	c.(715-717)CTG>CTT	p.L239L	TG_uc003ytw.2_Intron|TG_uc010mdw.2_Intron|TG_uc011ljb.1_Intron|TG_uc011ljc.1_Intron|SLA_uc011lje.1_Silent_p.L256L|SLA_uc011ljf.1_Silent_p.L131L|SLA_uc011ljg.1_Silent_p.L212L|SLA_uc011ljd.1_Silent_p.L279L	NM_001045556	NP_001039021	Q13239	SLAP1_HUMAN	Src-like-adaptor isoform a	239	SLA C-terminal.			LSL->QSQ: Abolishes interaction with CBL. Slightly affects dimerization.		endosome	SH3/SH2 adaptor activity			lung(1)|liver(1)	2	all_epithelial(106;3.51e-21)|Lung NSC(106;4.24e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0279)|Breast(495;0.037)	BRCA - Breast invasive adenocarcinoma(115;0.000701)			CCTCACTGGTCAGGGACAGGT	0.522		NA											37	75					8.74e-17	1.72e-16	1	0
CPSF1	29894	broad.mit.edu	37	8	145626066	145626066	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:145626066C>T	uc003zcj.2	-	7	760	c.685G>A	c.(685-687)GGG>AGG	p.G229R	CPSF1_uc003zck.1_Missense_Mutation_p.G151R|CPSF1_uc011lle.1_Missense_Mutation_p.G229R|MIR1234_hsa-mir-1234|MI0006324_5'Flank|CPSF1_uc011llf.1_Missense_Mutation_p.G229R	NM_013291	NP_037423	Q10570	CPSF1_HUMAN	cleavage and polyadenylation specific factor 1,	229					mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	mRNA 3'-UTR binding|protein binding			skin(1)	1	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.88e-41)|Epithelial(56;1.67e-40)|all cancers(56;1.2e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			GGGGCTCACCCAGGCCAGGTC	0.637		NA											8	19					0	0	0	0
KIAA1432	57589	broad.mit.edu	37	9	5757415	5757415	+	Silent	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:5757415T>C	uc003zji.2	+	16	1812	c.1719T>C	c.(1717-1719)AGT>AGC	p.S573S	KIAA1432_uc003zjh.2_Silent_p.S573S|KIAA1432_uc003zjl.3_Silent_p.S536S|KIAA1432_uc003zjj.1_Silent_p.S115S	NM_020829	NP_065880	Q4ADV7	RIC1_HUMAN	connexin 43-interacting protein 150 isoform a	652						integral to membrane					0		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		CATCAGTGAGTACAGAGAATG	0.413		NA											36	102					0	0	0	0
KDM4C	23081	broad.mit.edu	37	9	6984211	6984211	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:6984211G>T	uc003zkh.2	+	10	1741	c.1161G>T	c.(1159-1161)GAG>GAT	p.E387D	KDM4C_uc010mhu.2_Missense_Mutation_p.E409D|KDM4C_uc011lmi.1_Missense_Mutation_p.E387D|KDM4C_uc011lmj.1_RNA|KDM4C_uc003zkg.2_Missense_Mutation_p.E387D|KDM4C_uc011lmk.1_Missense_Mutation_p.E206D|KDM4C_uc011lml.1_Missense_Mutation_p.E74D	NM_015061	NP_055876	Q9H3R0	KDM4C_HUMAN	jumonji domain containing 2C isoform 1	387					positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	nuclear chromatin	androgen receptor binding|enzyme binding|histone demethylase activity (H3-K9 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1						AGGCTGATGAGGAAGAGGAAG	0.498		NA											21	51					2.38e-13	4.46e-13	1	0
PTPRD	5789	broad.mit.edu	37	9	8460478	8460478	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:8460478C>G	uc003zkk.2	-	32	4519	c.3808G>C	c.(3808-3810)GTT>CTT	p.V1270L	PTPRD_uc003zkp.2_Missense_Mutation_p.V859L|PTPRD_uc003zkq.2_Missense_Mutation_p.V859L|PTPRD_uc003zkr.2_Missense_Mutation_p.V854L|PTPRD_uc003zks.2_Missense_Mutation_p.V849L|PTPRD_uc003zkl.2_Missense_Mutation_p.V1261L|PTPRD_uc003zkm.2_Missense_Mutation_p.V1257L|PTPRD_uc003zkn.2_Missense_Mutation_p.V859L|PTPRD_uc003zko.2_Missense_Mutation_p.V856L	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1270	Helical; (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GGACCTACAACCCAGATCAAG	0.448		NA								TSP Lung(15;0.13)			19	51					0	0	0	0
BNC2	54796	broad.mit.edu	37	9	16437135	16437135	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:16437135G>A	uc003zml.2	-	6	1197	c.1057C>T	c.(1057-1059)CGG>TGG	p.R353W	BNC2_uc011lmw.1_Missense_Mutation_p.R258W|BNC2_uc003zmm.2_Missense_Mutation_p.R311W|BNC2_uc003zmq.1_Missense_Mutation_p.R367W|BNC2_uc003zmr.1_Missense_Mutation_p.R390W|BNC2_uc003zmp.1_Missense_Mutation_p.R381W|BNC2_uc010mij.1_Missense_Mutation_p.R275W|BNC2_uc011lmv.1_Missense_Mutation_p.R179W|BNC2_uc003zmo.1_Missense_Mutation_p.R275W|BNC2_uc003zmj.2_Missense_Mutation_p.R118W|BNC2_uc003zmk.2_RNA|BNC2_uc003zmi.2_Missense_Mutation_p.R118W|BNC2_uc003zmn.1_Missense_Mutation_p.R118W	NM_017637	NP_060107	Q6ZN30	BNC2_HUMAN	basonuclin 2	353					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(50;9.01e-08)		CTGGGTTCCCGCAGCCTCAAC	0.468		NA											30	101					0	0	0	0
ADAMTSL1	92949	broad.mit.edu	37	9	18889647	18889647	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:18889647G>A	uc003zne.3	+	25	4671	c.4544G>A	c.(4543-4545)TGC>TAC	p.C1515Y	ADAMTSL1_uc003znf.3_Missense_Mutation_p.C216Y	NM_001040272	NP_001035362	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1 isoform 4 precursor	1515						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)	5				GBM - Glioblastoma multiforme(50;1.29e-17)		CGCTTGAGGTGCCTGCTGAAC	0.642		NA											8	20					0	0	0	0
PLAA	9373	broad.mit.edu	37	9	26905641	26905641	+	Silent	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:26905641A>G	uc003zqd.2	-	14	2681	c.2256T>C	c.(2254-2256)CTT>CTC	p.L752L		NM_001031689	NP_001026859	Q9Y263	PLAP_HUMAN	phospholipase A2-activating protein	752	PUL.				phospholipid metabolic process|signal transduction		phospholipase A2 activator activity				0		all_neural(3;3.53e-10)|Glioma(3;2.71e-09)		Lung(218;1.32e-05)|LUSC - Lung squamous cell carcinoma(38;0.00011)		CATCACTGATAAGTGTTCCAA	0.373		NA											18	53					0	0	0	0
PRSS3	5646	broad.mit.edu	37	9	33799064	33799064	+	Silent	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:33799064C>G	uc003ztj.3	+	5	801	c.801C>G	c.(799-801)CTC>CTG	p.L267L	uc003ztk.1_Intron|PRSS3_uc003zti.3_Silent_p.L224L|PRSS3_uc003ztl.3_Silent_p.L210L	NM_007343	NP_031369	P35030	TRY3_HUMAN	mesotrypsin isoform 1 preproprotein	267	Peptidase S1.				digestion|endothelial cell migration|zymogen activation	extracellular space	calcium ion binding|protein binding|serine-type endopeptidase activity|serine-type peptidase activity				0			LUSC - Lung squamous cell carcinoma(29;0.0176)			ACGGACAGCTCCAAGGAGTTG	0.522		NA											34	100					0	0	0	0
VCP	7415	broad.mit.edu	37	9	35061050	35061050	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:35061050C>A	uc003zvy.2	-	11	1710	c.1321G>T	c.(1321-1323)GTC>TTC	p.V441F	VCP_uc003zvz.2_RNA|VCP_uc010mkh.1_Missense_Mutation_p.V110F|VCP_uc010mki.1_Missense_Mutation_p.V396F	NM_007126	NP_009057	P55072	TERA_HUMAN	valosin-containing protein	441					activation of caspase activity|double-strand break repair|endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|retrograde protein transport, ER to cytosol	cytosol|endoplasmic reticulum|microsome|nucleus|proteasome complex	ATP binding|ATPase activity|lipid binding|polyubiquitin binding|protein domain specific binding|protein phosphatase binding			upper_aerodigestive_tract(1)	1			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			GAGTTCATGACCTCGGCATCA	0.527		NA											54	181					1.55e-18	3.11e-18	1	0
RUSC2	9853	broad.mit.edu	37	9	35557972	35557972	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:35557972G>T	uc003zww.2	+	6	3300	c.3045G>T	c.(3043-3045)CGG>CGT	p.R1015R	RUSC2_uc010mkq.2_RNA|RUSC2_uc003zwx.3_Silent_p.R1015R	NM_014806	NP_055621	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	1015						cytosol				ovary(1)	1			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			GCACAAGCCGGGATCCCGGGG	0.557		NA											24	73					3.8e-20	7.72e-20	1	0
TESK1	7016	broad.mit.edu	37	9	35609311	35609311	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:35609311C>T	uc003zxa.2	+	10	1789	c.1453C>T	c.(1453-1455)CAG>TAG	p.Q485*	TESK1_uc003zwz.1_RNA|TESK1_uc010mks.2_Nonsense_Mutation_p.Q325*	NM_006285	NP_006276	Q15569	TESK1_HUMAN	testis-specific protein kinase 1	485					cell junction assembly|spermatogenesis	cytosol	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			stomach(2)|breast(2)|lung(1)|ovary(1)|skin(1)	7			Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			GCCAGCGCCCCAGCTGCCTCT	0.647		NA											23	59					0	0	0	0
SPAG8	26206	broad.mit.edu	37	9	35809452	35809452	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:35809452C>A	uc003zye.2	-	7	1436	c.1321G>T	c.(1321-1323)GAA>TAA	p.E441*	NPR2_uc003zyd.2_3'UTR|NPR2_uc010mlb.2_3'UTR	NM_172312	NP_758516	Q99932	SPAG8_HUMAN	sperm associated antigen 8 isoform 2	Error:Variant_position_missing_in_Q99932_after_alignment						acrosomal vesicle|membrane				ovary(1)	1	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)			AACCCCCATTCTTTCCAAGTC	0.493		NA											99	244					3.37e-40	7.18e-40	1	0
PAX5	5079	broad.mit.edu	37	9	36846845	36846845	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:36846845A>T	uc003zzo.1	-	9	1542	c.1094T>A	c.(1093-1095)CTG>CAG	p.L365Q	PAX5_uc011lpt.1_Missense_Mutation_p.L161Q|PAX5_uc011lpu.1_RNA|PAX5_uc011lpv.1_Intron|PAX5_uc011lpw.1_Intron|PAX5_uc011lpx.1_Missense_Mutation_p.L265Q|PAX5_uc011lpy.1_Intron|PAX5_uc010mls.1_Intron|PAX5_uc011lpz.1_Missense_Mutation_p.L322Q|PAX5_uc011lqa.1_Missense_Mutation_p.L257Q|PAX5_uc010mlq.1_RNA|PAX5_uc011lqb.1_RNA|PAX5_uc010mlo.1_Missense_Mutation_p.L331Q|PAX5_uc010mlp.1_Intron|PAX5_uc011lqc.1_Intron|PAX5_uc010mlr.1_Missense_Mutation_p.C288S	NM_016734	NP_057953	Q02548	PAX5_HUMAN	paired box 5	365					cell differentiation|humoral immune response|nervous system development|organ morphogenesis|spermatogenesis|transcription from RNA polymerase II promoter	nucleus	DNA binding	p.?(11)	PAX5/JAK2(18)	haematopoietic_and_lymphoid_tissue(142)|lung(3)|central_nervous_system(2)	147		all_cancers(2;3.46e-10)|Acute lymphoblastic leukemia(2;7.09e-56)|all_hematologic(2;6.65e-44)		GBM - Glioblastoma multiforme(29;0.0108)		CTCACCAAGCAGCCCCGGGTT	0.632		NA	T|Mis|D|F|S	IGH@|ETV6|PML|FOXP1|ZNF521|ELN	NHL|ALL|B-ALL								9	23					0	0	0	0
FBXO10	26267	broad.mit.edu	37	9	37531943	37531943	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:37531943C>G	uc004aab.2	-	4	1581	c.1532G>C	c.(1531-1533)GGT>GCT	p.G511A	FBXO10_uc004aac.2_Missense_Mutation_p.G527A|FBXO10_uc004aad.2_Missense_Mutation_p.G61A	NM_012166	NP_036298	Q9UK96	FBX10_HUMAN	F-box protein 10	511	PbH1 6.					ubiquitin ligase complex	ubiquitin-protein ligase activity			lung(5)	5				GBM - Glioblastoma multiforme(29;0.0107)		GATGTCTACACCAGCCTCTGC	0.493		NA											12	42					0	0	0	0
FRMPD1	22844	broad.mit.edu	37	9	37745967	37745967	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:37745967C>A	uc004aag.1	+	16	3982	c.3938C>A	c.(3937-3939)GCC>GAC	p.A1313D	FRMPD1_uc004aah.1_Missense_Mutation_p.A1313D	NM_014907	NP_055722	Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	1313						cytoskeleton|cytosol|plasma membrane				ovary(4)|central_nervous_system(2)|skin(2)|breast(1)	9				GBM - Glioblastoma multiforme(29;0.00655)		CTCAGGGTGGCCACATCTTTG	0.532		NA											33	91					1.08e-15	2.11e-15	1	0
C9orf71	169693	broad.mit.edu	37	9	71152371	71152371	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:71152371T>A	uc004agt.2	-	2	370	c.317A>T	c.(316-318)GAG>GTG	p.E106V	uc004ags.1_RNA	NM_153237	NP_694969	Q8N6L7	CI071_HUMAN	hypothetical protein LOC169693	106						integral to membrane					0						CTTTTCCACCTCAAGGCTCTC	0.498		NA											16	40					0	0	0	0
TJP2	9414	broad.mit.edu	37	9	71835869	71835869	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:71835869G>A	uc004ahe.2	+	5	609	c.409G>A	c.(409-411)GAC>AAC	p.D137N	TJP2_uc011lrs.1_Missense_Mutation_p.D114N|TJP2_uc004ahb.1_Missense_Mutation_p.D114N|TJP2_uc011lrt.1_Missense_Mutation_p.D114N|TJP2_uc004ahd.2_Missense_Mutation_p.D137N|TJP2_uc004ahf.2_Missense_Mutation_p.D137N|TJP2_uc011lru.1_Missense_Mutation_p.D141N|TJP2_uc011lrv.1_Missense_Mutation_p.D159N	NM_004817	NP_004808	Q9UDY2	ZO2_HUMAN	tight junction protein 2 (zona occludens 2)	137					cellular component disassembly involved in apoptosis	adherens junction|cytoplasm|nucleus|tight junction	guanylate kinase activity|protein binding				0						GGATCAGGATGACCGGGCTTT	0.612		NA											7	22					0	0	0	0
RORB	6096	broad.mit.edu	37	9	77282809	77282809	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:77282809T>A	uc004aji.2	+	8	1185	c.1136T>A	c.(1135-1137)ATA>AAA	p.I379K	RORB_uc004ajh.2_Missense_Mutation_p.I368K	NM_006914	NP_008845	Q92753	RORB_HUMAN	RAR-related orphan receptor B	379	Ligand-binding (Potential).				eye photoreceptor cell development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|visual perception	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(2)|lung(1)|skin(1)	4						GCTGTTCTGATATCTCCAGGT	0.413		NA											12	56					0	0	0	0
FOXB2	442425	broad.mit.edu	37	9	79635323	79635323	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:79635323G>T	uc004ako.1	+	1	753	c.753G>T	c.(751-753)TCG>TCT	p.S251S		NM_001013735	NP_001013757	Q5VYV0	FOXB2_HUMAN	forkhead box B2	251					brain development|embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0						GGCTGGGCTCGgccgccgccg	0.388		NA											7	17					2.77e-08	4.76e-08	1	0
FLJ46321	389763	broad.mit.edu	37	9	84606419	84606419	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:84606419G>T	uc004amn.2	+	4	1081	c.1034G>T	c.(1033-1035)GGC>GTC	p.G345V		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	345						integral to membrane					0						ACAATCAAAGGCATTGACCAT	0.458		NA											39	84					1.07e-22	2.21e-22	1	0
FLJ46321	389763	broad.mit.edu	37	9	84608333	84608333	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:84608333T>C	uc004amn.2	+	4	2995	c.2948T>C	c.(2947-2949)CTT>CCT	p.L983P		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	983						integral to membrane					0						GTCCCCATCCTTGATCGTCCT	0.488		NA											67	124					0	0	0	0
FLJ46321	389763	broad.mit.edu	37	9	84608809	84608809	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:84608809G>T	uc004amn.2	+	4	3471	c.3424G>T	c.(3424-3426)GGC>TGC	p.G1142C		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	1142						integral to membrane					0						CAGGCTTCAGGGCAGTAGAAA	0.468		NA											21	30					1.01e-13	1.91e-13	1	0
NOL8	55035	broad.mit.edu	37	9	95076834	95076834	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:95076834T>C	uc004arv.2	-	7	2410	c.2073A>G	c.(2071-2073)ATA>ATG	p.I691M	NOL8_uc010mqw.2_RNA|NOL8_uc004arw.2_Intron|NOL8_uc011ltw.1_Missense_Mutation_p.I623M	NM_017948	NP_060418	Q76FK4	NOL8_HUMAN	nucleolar protein 8	691					DNA replication|positive regulation of cell growth	nucleolus	nucleotide binding|protein binding|RNA binding			ovary(1)	1						TGTCAAAGCCTATGTTGTGAG	0.438		NA											7	52					0	0	0	0
SUSD3	203328	broad.mit.edu	37	9	95846964	95846964	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:95846964C>G	uc004atb.2	+	5	739	c.703C>G	c.(703-705)CCC>GCC	p.P235A	SUSD3_uc004atc.2_Missense_Mutation_p.P222A	NM_145006	NP_659443	Q96L08	SUSD3_HUMAN	sushi domain containing 3	235	Cytoplasmic (Potential).					integral to membrane				breast(2)|skin(2)|ovary(1)|lung(1)	6						CCCCAGACAGCCCCTGCCTGC	0.637		NA											52	157					0	0	0	0
WNK2	65268	broad.mit.edu	37	9	96025977	96025977	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:96025977G>T	uc004ati.1	+	14	3540	c.3540G>T	c.(3538-3540)CGG>CGT	p.R1180R	WNK2_uc011lud.1_Silent_p.R1180R|WNK2_uc004atj.2_Silent_p.R1180R|WNK2_uc004atk.2_Silent_p.R817R	NM_006648	NP_006639	Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	1180					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|stomach(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)|breast(1)	12						CGCGCTCCCGGCAGGAGAGGG	0.537		NA											6	9					5.94e-07	9.85e-07	1	0
PTPDC1	138639	broad.mit.edu	37	9	96859788	96859788	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:96859788G>T	uc004auf.1	+	7	1118	c.778G>T	c.(778-780)GCT>TCT	p.A260S	PTPDC1_uc004aug.1_Missense_Mutation_p.A260S|PTPDC1_uc004auh.1_Missense_Mutation_p.A312S|PTPDC1_uc010mrj.1_Missense_Mutation_p.A314S|PTPDC1_uc010mri.1_Missense_Mutation_p.A312S	NM_177995	NP_818931	A2A3K4	PTPC1_HUMAN	protein tyrosine phosphatase domain containing 1	260							protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(1)	1						CAAAGCACATGCTGTCACCTT	0.438		NA											129	76					1.62e-62	3.47e-62	1	0
GABBR2	9568	broad.mit.edu	37	9	101216274	101216274	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:101216274A>G	uc004ays.2	-	7	1381	c.1225T>C	c.(1225-1227)TTC>CTC	p.F409L		NM_005458	NP_005449	O75899	GABR2_HUMAN	G protein-coupled receptor 51 precursor	409	Extracellular (Potential).				negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity			ovary(2)|skin(2)	4		Acute lymphoblastic leukemia(62;0.0527)			Baclofen(DB00181)	GTGACCCCGAAGAAGTTGGTC	0.532		NA											73	70					0	0	0	0
CYLC2	1539	broad.mit.edu	37	9	105765547	105765547	+	Splice_Site	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:105765547T>C	uc004bbs.2	+	3	250	c.180_splice	c.e3+2	p.S60_splice		NM_001340	NP_001331	Q14093	CYLC2_HUMAN	cylicin 2						cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			skin(1)	1		all_hematologic(171;0.125)				ACGGTTTCTGTAAGCATTGGA	0.284		NA											16	52					0	0	0	0
OR13C9	286362	broad.mit.edu	37	9	107379790	107379790	+	Silent	SNP	C	C	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:107379790C>T	uc011lvr.1	-	1	696	c.696G>A	c.(694-696)GAG>GAA	p.E232E		NM_001001956	NP_001001956	Q8NGT0	O13C9_HUMAN	olfactory receptor, family 13, subfamily C,	232	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TGCTTCTCCCCTCAGAGGAGT	0.428		NA											19	85					0	0	0	0
RGS3	5998	broad.mit.edu	37	9	116353656	116353656	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:116353656G>T	uc004bhq.2	+	22	3268	c.3059G>T	c.(3058-3060)CGG>CTG	p.R1020L	RGS3_uc004bhs.2_Missense_Mutation_p.R910L|RGS3_uc004bht.2_Missense_Mutation_p.R739L|RGS3_uc010muy.2_Missense_Mutation_p.R413L|RGS3_uc004bhv.2_Missense_Mutation_p.R341L|RGS3_uc010muz.1_Missense_Mutation_p.R359L|RGS3_uc004bhw.2_Intron|RGS3_uc011lxh.1_Missense_Mutation_p.R330L|RGS3_uc004bhx.2_Missense_Mutation_p.R341L|RGS3_uc004bhy.1_Missense_Mutation_p.R330L|RGS3_uc004bhz.2_Missense_Mutation_p.R362L|RGS3_uc004bia.2_5'Flank	NM_144488	NP_652759	P49796	RGS3_HUMAN	regulator of G-protein signalling 3 isoform 6	1020					inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	cytosol|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			ovary(1)|lung(1)|skin(1)	3						GAAGCCTCCCGGAAGAGAAAG	0.587		NA											24	63					2.45e-14	4.67e-14	1	0
ORM2	5005	broad.mit.edu	37	9	117092788	117092788	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:117092788A>T	uc004bil.2	+	2	305	c.189A>T	c.(187-189)CAA>CAT	p.Q63H	ORM1_uc011lxo.1_Intron	NM_000608	NP_000599	P19652	A1AG2_HUMAN	orosomucoid 2 precursor	63					acute-phase response|regulation of immune system process|transport	extracellular space	binding				0		Myeloproliferative disorder(63;0.163)				AGGAGATCCAAGCAACCTTCT	0.512		NA											28	48					0	0	0	0
TNC	3371	broad.mit.edu	37	9	117849088	117849088	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:117849088C>A	uc004bjj.3	-	3	1284	c.922G>T	c.(922-924)GAA>TAA	p.E308*	TNC_uc010mvf.2_Nonsense_Mutation_p.E308*	NM_002160	NP_002151	P24821	TENA_HUMAN	tenascin C precursor	308	EGF-like 5.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			central_nervous_system(4)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	7						CTGCAGTCTTCGCCCGTGAAA	0.557		NA											53	79					2.12e-23	4.4e-23	1	0
PAPPA	5069	broad.mit.edu	37	9	118950331	118950331	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:118950331G>T	uc004bjn.2	+	2	1695	c.1314G>T	c.(1312-1314)GGG>GGT	p.G438G	PAPPA_uc011lxp.1_Silent_p.G231G|PAPPA_uc011lxq.1_Silent_p.G231G	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	438	Metalloprotease.				cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						ACGACGGCGGGGATTGCCGCC	0.597		NA											17	62					1.45e-14	2.78e-14	1	0
ASTN2	23245	broad.mit.edu	37	9	119976723	119976723	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:119976723C>A	uc004bjs.1	-	3	1030	c.929G>T	c.(928-930)CGC>CTC	p.R310L	ASTN2_uc004bjr.1_Missense_Mutation_p.R310L|ASTN2_uc004bjt.1_Missense_Mutation_p.R310L	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	310	Cytoplasmic (Potential).					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						CTCGTCCTCGCGGGAGACATG	0.577		NA											28	93					2.66e-16	5.23e-16	1	0
DBC1	1620	broad.mit.edu	37	9	122075568	122075568	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:122075568G>A	uc004bkc.2	-	2	522	c.66C>T	c.(64-66)CCC>CCT	p.P22P	DBC1_uc004bkd.2_Silent_p.P22P	NM_014618	NP_055433	O60477	DBC1_HUMAN	deleted in bladder cancer 1 precursor	22					cell cycle arrest|cell death	cytoplasm	protein binding			skin(3)|ovary(2)|central_nervous_system(2)|large_intestine(1)	8						CCTGGTGGGAGGGCTGCACTG	0.512		NA											43	54					0	0	0	0
CDK5RAP2	55755	broad.mit.edu	37	9	123177356	123177356	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:123177356C>G	uc004bkf.2	-	28	4440	c.4259G>C	c.(4258-4260)CGG>CCG	p.R1420P	CDK5RAP2_uc010mvi.2_Missense_Mutation_p.R429P|CDK5RAP2_uc004bke.2_Missense_Mutation_p.R705P|CDK5RAP2_uc004bkg.2_Missense_Mutation_p.R1420P|CDK5RAP2_uc011lxw.1_Missense_Mutation_p.R685P|CDK5RAP2_uc011lxx.1_RNA|CDK5RAP2_uc011lxy.1_RNA|CDK5RAP2_uc011lxz.1_Missense_Mutation_p.R685P|CDK5RAP2_uc011lya.1_Missense_Mutation_p.R685P|CDK5RAP2_uc004bkh.1_Missense_Mutation_p.R1190P|CDK5RAP2_uc004bki.2_Missense_Mutation_p.R1187P	NM_018249	NP_060719	Q96SN8	CK5P2_HUMAN	CDK5 regulatory subunit associated protein 2	1420					brain development|centrosome organization|chromosome segregation|G2/M transition of mitotic cell cycle|microtubule bundle formation|negative regulation of centriole replication|positive regulation of transcription, DNA-dependent|regulation of neuron differentiation|regulation of spindle checkpoint	cytosol|Golgi apparatus|microtubule|pericentriolar material|perinuclear region of cytoplasm|spindle pole	calmodulin binding|microtubule binding|neuronal Cdc2-like kinase binding|transcription regulatory region DNA binding			ovary(2)|lung(1)|skin(1)	4						CAACTGTTTCCGTAGCTTCTC	0.408		NA											23	93					0	0	0	0
CEP110	11064	broad.mit.edu	37	9	123875817	123875817	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:123875817A>G	uc004bkx.1	+	8	1191	c.1160A>G	c.(1159-1161)TAC>TGC	p.Y387C	CEP110_uc004bkw.2_Missense_Mutation_p.Y387C|CEP110_uc004bky.1_5'UTR	NM_007018	NP_008949	Q7Z7A1	CNTRL_HUMAN	centrosomal protein 110kDa	387					cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding				0						GAAAGCCCTTACATTGGCAAA	0.358		NA											26	64					0	0	0	0
RBM18	92400	broad.mit.edu	37	9	125004254	125004254	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:125004254T>G	uc004bma.2	-	6	648	c.482A>C	c.(481-483)TAT>TCT	p.Y161S	RBM18_uc004blz.2_RNA|RBM18_uc010mvy.2_RNA|RBM18_uc011lyp.1_RNA	NM_033117	NP_149108	Q96H35	RBM18_HUMAN	RNA binding motif protein 18	161							nucleotide binding|RNA binding				0						CGCTGCTGGATACTCTGCATC	0.408		NA											18	62					0	0	0	0
PTGS1	5742	broad.mit.edu	37	9	125154751	125154751	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:125154751C>A	uc004bmg.1	+	11	1863	c.1728C>A	c.(1726-1728)TAC>TAA	p.Y576*	PTGS1_uc011lys.1_Nonsense_Mutation_p.Y514*|PTGS1_uc010mwb.1_Nonsense_Mutation_p.Y430*|PTGS1_uc004bmf.1_Nonsense_Mutation_p.Y539*|PTGS1_uc004bmh.1_Nonsense_Mutation_p.Y467*|PTGS1_uc011lyt.1_Nonsense_Mutation_p.Y467*	NM_000962	NP_000953	P23219	PGH1_HUMAN	prostaglandin-endoperoxide synthase 1 isoform 1	576					cyclooxygenase pathway|hormone biosynthetic process|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum membrane|Golgi apparatus|microsome|plasma membrane	heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			ovary(1)|skin(1)	2					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Dipyrone(DB04817)|Etodolac(DB00749)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Mesalazine(DB00244)|Minoxidil(DB00350)|Nabumetone(DB00461)|Naproxen(DB00788)|Phenacetin(DB03783)|Piroxicam(DB00554)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Tolmetin(DB00500)	CCTGTCCCTACGTTTCCTTCC	0.582		NA											31	100					2.61e-14	4.98e-14	1	0
OR1L6	392390	broad.mit.edu	37	9	125512443	125512443	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:125512443T>C	uc011lzc.1	+	1	425	c.425T>C	c.(424-426)ATG>ACG	p.M142T		NM_001004453	NP_001004453	Q8NGR2	OR1L6_HUMAN	olfactory receptor, family 1, subfamily L,	142	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TACTTCTTTATGGCATTTGGG	0.488		NA											34	148					0	0	0	0
LRSAM1	90678	broad.mit.edu	37	9	130241717	130241717	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:130241717G>T	uc004brb.1	+	13	1181	c.836G>T	c.(835-837)CGG>CTG	p.R279L	LRSAM1_uc010mxk.1_Missense_Mutation_p.R279L|LRSAM1_uc004brc.1_Missense_Mutation_p.R279L|LRSAM1_uc004brd.1_Missense_Mutation_p.R279L|LRSAM1_uc004bre.1_5'UTR	NM_001005373	NP_001005373	Q6UWE0	LRSM1_HUMAN	leucine rich repeat and sterile alpha motif	279	Potential.				negative regulation of endocytosis|non-lytic virus budding|protein autoubiquitination|protein catabolic process|protein polyubiquitination|protein transport|ubiquitin-dependent endocytosis	cytoplasm|extracellular region|membrane part	hormone activity|ubiquitin-protein ligase activity|zinc ion binding				0						CTGGGGCAGCGGGAGCACACC	0.602		NA											29	32					7.01e-11	1.27e-10	1	0
SH2D3C	10044	broad.mit.edu	37	9	130506941	130506941	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:130506941G>T	uc004bsc.2	-	7	1844	c.1702C>A	c.(1702-1704)CGG>AGG	p.R568R	SH2D3C_uc010mxo.2_Silent_p.R408R|SH2D3C_uc004bry.2_Silent_p.R410R|SH2D3C_uc004brz.3_Silent_p.R214R|SH2D3C_uc011mak.1_Silent_p.R214R|SH2D3C_uc004bsa.2_Silent_p.R411R|SH2D3C_uc004bsb.2_Silent_p.R500R	NM_170600	NP_733745	Q8N5H7	SH2D3_HUMAN	SH2 domain containing 3C isoform a	568					JNK cascade|small GTPase mediated signal transduction	cytoplasm|membrane	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			ovary(1)	1						TCCAGTGGCCGGTTATCCCTG	0.612		NA											48	135					5.34e-22	1.1e-21	1	0
LAMC3	10319	broad.mit.edu	37	9	133946978	133946978	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:133946978G>A	uc004caa.1	+	18	3275	c.3177G>A	c.(3175-3177)AGG>AGA	p.R1059R		NM_006059	NP_006050	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3 precursor	1059	Cell attachment site (Potential).|Domain II and I.				cell adhesion	basement membrane|membrane	structural molecule activity			ovary(2)|pancreas(1)	3	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		AGGCCCCAAGGGGGGACGTCT	0.657		NA											26	38					0	0	0	0
NUP214	8021	broad.mit.edu	37	9	134021593	134021593	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:134021593C>A	uc004cag.2	+	13	1958	c.1847C>A	c.(1846-1848)TCC>TAC	p.S616Y	NUP214_uc004cah.2_Missense_Mutation_p.S605Y|NUP214_uc004cai.2_Missense_Mutation_p.S45Y|NUP214_uc004caf.1_Missense_Mutation_p.S605Y|NUP214_uc010mzf.2_5'UTR	NM_005085	NP_005076	P35658	NU214_HUMAN	nucleoporin 214kDa	616	11 X 5 AA approximate repeats.				carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			breast(7)|lung(3)|skin(3)|ovary(2)|central_nervous_system(1)	16	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		TCTTCTGCCTCCAAGCCAGCT	0.567		NA	T	DEK|SET|ABL1	AML|T-ALL								231	318					1.96e-89	4.2e-89	1	0
BAT2L1	84726	broad.mit.edu	37	9	134350269	134350269	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:134350269G>T	uc004can.3	+	15	2808	c.2753G>T	c.(2752-2754)TGG>TTG	p.W918L	BAT2L1_uc010mzj.1_Missense_Mutation_p.W501L|BAT2L1_uc004cao.3_Missense_Mutation_p.W276L	NM_013318	NP_037450	Q5JSZ5	PRC2B_HUMAN	HLA-B associated transcript 2-like	918							protein binding				0						GAGCCTGAATGGACTCCCGAG	0.642		NA											8	8					5.18e-06	8.36e-06	1	0
POMT1	10585	broad.mit.edu	37	9	134394277	134394277	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:134394277G>A	uc004cav.2	+	15	1687	c.1485G>A	c.(1483-1485)GGG>GGA	p.G495G	POMT1_uc004cax.2_Silent_p.G473G|POMT1_uc011mcj.1_Silent_p.G251G|POMT1_uc004cau.2_Silent_p.G473G|POMT1_uc004caw.2_Silent_p.G419G|POMT1_uc011mck.1_Silent_p.G356G|POMT1_uc011mcl.1_Silent_p.G321G|POMT1_uc011mcm.1_Silent_p.G443G|POMT1_uc011mcn.1_3'UTR	NM_007171	NP_009102	Q9Y6A1	POMT1_HUMAN	protein-O-mannosyltransferase 1 isoform a	495	MIR 3.				multicellular organismal development|protein O-linked glycosylation	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity|metal ion binding			upper_aerodigestive_tract(1)	1		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.65e-05)|Epithelial(140;0.000259)		AGATCGTCGGGGAGAAGCTGT	0.677		NA											22	47					0	0	0	0
SURF2	6835	broad.mit.edu	37	9	136226863	136226863	+	Silent	SNP	T	T	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:136226863T>C	uc004cdi.2	+	4	423	c.375T>C	c.(373-375)CCT>CCC	p.P125P		NM_017503	NP_059973	Q15527	SURF2_HUMAN	surfeit 2	125							protein binding				0				OV - Ovarian serous cystadenocarcinoma(145;4.87e-07)|Epithelial(140;4.02e-06)|all cancers(34;3.71e-05)		AGTACGTGCCTGCCTGCCTGG	0.647		NA											9	23					0	0	0	0
SEC16A	9919	broad.mit.edu	37	9	139353630	139353630	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:139353630C>G	uc004chx.2	-	17	5674	c.5365G>C	c.(5365-5367)GCC>CCC	p.A1789P	SEC16A_uc004chu.2_5'Flank|SEC16A_uc004chv.3_Missense_Mutation_p.A1179P|SEC16A_uc004chw.2_Missense_Mutation_p.A1789P|SEC16A_uc010nbn.2_Missense_Mutation_p.A1789P	NM_014866	NP_055681	O15027	SC16A_HUMAN	SEC16 homolog A	1611					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane					0		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)		AGGGACTGGGCGTACTCATAG	0.522		NA											60	65					0	0	0	0
SHOX	6473	broad.mit.edu	37	X	601734	601734	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:601734G>T	uc004cph.1	+	5	1236	c.545G>T	c.(544-546)GGC>GTC	p.G182V	SHOX_uc004cpi.2_Missense_Mutation_p.G182V	NM_000451	NP_000442	O15266	SHOX_HUMAN	short stature homeobox isoform SHOXa	182					skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TTGGACACAGGCGTCATCTTG	0.602		NA											18	49					8.28e-16	1.62e-15	1	0
TLR7	51284	broad.mit.edu	37	X	12906382	12906382	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:12906382C>G	uc004cvc.2	+	3	2894	c.2755C>G	c.(2755-2757)CCA>GCA	p.P919A		NM_016562	NP_057646	Q9NYK1	TLR7_HUMAN	toll-like receptor 7 precursor	919	TIR.|Cytoplasmic (Potential).				cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity			ovary(2)|lung(2)|breast(1)	5					Imiquimod(DB00724)	ACTGGAAGACCCAAGAGAGAA	0.458		NA											56	47					0	0	0	0
SMS	6611	broad.mit.edu	37	X	22010722	22010722	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:22010722G>A	uc004dag.2	+	10	1054	c.953G>A	c.(952-954)TGT>TAT	p.C318Y	SMS_uc010nfs.2_RNA|SMS_uc010nft.2_Intron	NM_004595	NP_004586	P52788	SPSY_HUMAN	spermine synthase	318					methionine metabolic process|spermine biosynthetic process	cytosol	spermidine synthase activity|spermine synthase activity			ovary(1)	1					Spermine(DB00127)	TAGGGGAACTGTGTCAATCTG	0.453		NA											4	7					0	0	0	0
DCAF8L2	347442	broad.mit.edu	37	X	27766738	27766738	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:27766738G>T	uc011mjy.1	+	1	1813	c.1726G>T	c.(1726-1728)GAC>TAC	p.D576Y		NM_001136533	NP_001130005			DDB1 and CUL4 associated factor 8-like 2											central_nervous_system(1)|pancreas(1)	2						CAGCCTGTTTGACCAGTACAT	0.498		NA											11	9					1.59e-06	2.59e-06	1	0
MAGEB10	139422	broad.mit.edu	37	X	27839501	27839501	+	Silent	SNP	A	A	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:27839501A>T	uc004dbw.2	+	3	305	c.78A>T	c.(76-78)ATA>ATT	p.I26I		NM_182506	NP_872312	Q96LZ2	MAGBA_HUMAN	melanoma antigen family B, 10	26										lung(1)|breast(1)|central_nervous_system(1)	3						AAGATTTGATAGATGCTCTGG	0.512		NA											18	20					0	0	0	0
IL1RAPL1	11141	broad.mit.edu	37	X	29973704	29973704	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:29973704C>G	uc004dby.2	+	11	2366	c.1858C>G	c.(1858-1860)CGT>GGT	p.R620G		NM_014271	NP_055086	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	620	Cytoplasmic (Potential).|Interaction with NCS1.				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			ovary(3)|lung(1)|pancreas(1)	5						TTCACAAATGCGTCAGAAACA	0.532		NA											7	10					0	0	0	0
NR0B1	190	broad.mit.edu	37	X	30326348	30326348	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:30326348T>G	uc004dcf.3	-	1	1148	c.1133A>C	c.(1132-1134)TAC>TCC	p.Y378S		NM_000475	NP_000466	P51843	NR0B1_HUMAN	nuclear receptor subfamily 0, group B, member 1	378	Ligand-binding (By similarity).				adrenal gland development|hypothalamus development|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of steroid hormone receptor signaling pathway|pituitary gland development|protein localization|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|steroid biosynthetic process	cytoplasm|membrane fraction|nucleoplasm|nucleus|polysomal ribosome	AF-2 domain binding|DNA hairpin binding|ligand-regulated transcription factor activity|protein domain specific binding|protein homodimerization activity|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|steroid hormone receptor binding|transcription corepressor activity|transcription factor binding			ovary(1)|lung(1)	2					Dexamethasone(DB01234)|Tretinoin(DB00755)	GAGGTAGGCGTACTCCTTGGT	0.587		NA									OREG0019719	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	22					0	0	0	0
PPP1R3F	89801	broad.mit.edu	37	X	49142667	49142667	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:49142667G>A	uc004dnh.1	+	4	1531	c.1515G>A	c.(1513-1515)GCG>GCA	p.A505A	PPP1R3F_uc011mnd.1_Silent_p.A176A|PPP1R3F_uc004dni.2_Silent_p.A159A|PPP1R3F_uc004dnj.1_Silent_p.A159A	NM_033215	NP_149992	Q6ZSY5	PPR3F_HUMAN	protein phosphatase 1, regulatory (inhibitor)	505	Extracellular (Potential).					integral to membrane				ovary(2)|skin(1)	3	Ovarian(276;0.236)					CTGTGGCTGCGGGTGGGGCAG	0.657		NA											8	2					0	0	0	0
CCNB3	85417	broad.mit.edu	37	X	50052855	50052855	+	Silent	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:50052855T>A	uc004dox.3	+	6	1984	c.1686T>A	c.(1684-1686)TCT>TCA	p.S562S	CCNB3_uc004doy.2_Silent_p.S562S|CCNB3_uc004doz.2_Intron|CCNB3_uc010njq.2_Intron	NM_033031	NP_149020	Q8WWL7	CCNB3_HUMAN	cyclin B3 isoform 3	562					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			ovary(4)|lung(3)|large_intestine(1)|pancreas(1)	9	Ovarian(276;0.236)					ATAAGAATTCTTTCTTTATGG	0.373		NA											10	10					0	0	0	0
CCNB3	85417	broad.mit.edu	37	X	50053222	50053222	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:50053222A>C	uc004dox.3	+	6	2351	c.2053A>C	c.(2053-2055)AAA>CAA	p.K685Q	CCNB3_uc004doy.2_Missense_Mutation_p.K685Q|CCNB3_uc004doz.2_Intron|CCNB3_uc010njq.2_Intron	NM_033031	NP_149020	Q8WWL7	CCNB3_HUMAN	cyclin B3 isoform 3	685					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			ovary(4)|lung(3)|large_intestine(1)|pancreas(1)	9	Ovarian(276;0.236)					GCATACCAACAAAAGTGGGTC	0.463		NA											10	10					0	0	0	0
TRO	7216	broad.mit.edu	37	X	54949662	54949662	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:54949662A>G	uc004dtq.2	+	3	804	c.697A>G	c.(697-699)ACC>GCC	p.T233A	TRO_uc011moj.1_Missense_Mutation_p.T176A|TRO_uc004dts.2_Missense_Mutation_p.T233A|TRO_uc004dtr.2_Missense_Mutation_p.T233A|TRO_uc004dtt.2_RNA|TRO_uc004dtu.2_Intron|TRO_uc004dtv.2_Intron|TRO_uc011mok.1_Intron|TRO_uc004dtw.2_Intron|TRO_uc004dtx.2_5'Flank	NM_001039705	NP_001034794	Q12816	TROP_HUMAN	trophinin isoform 5	233					embryo implantation|homophilic cell adhesion	integral to plasma membrane				ovary(1)	1						CCATACAGCTACCACCCAAGG	0.512		NA											23	11					0	0	0	0
TBX22	50945	broad.mit.edu	37	X	79286337	79286337	+	Missense_Mutation	SNP	T	T	G	rs144871606	byFrequency	TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:79286337T>G	uc010nmg.1	+	9	1424	c.1290T>G	c.(1288-1290)AGT>AGG	p.S430R	TBX22_uc004edi.1_Missense_Mutation_p.S310R|TBX22_uc004edj.1_Missense_Mutation_p.S430R	NM_001109878	NP_001103348	Q9Y458	TBX22_HUMAN	T-box 22 isoform 1	430					multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(7)|large_intestine(3)|central_nervous_system(2)|breast(1)|skin(1)|ovary(1)	15						AAGACTCCAGTGATCAGTATC	0.433		NA											41	36					0	0	0	0
CSTF2	1478	broad.mit.edu	37	X	100088319	100088319	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:100088319G>T	uc004egh.2	+	11	1416	c.1358G>T	c.(1357-1359)CGT>CTT	p.R453L	CSTF2_uc010nnd.2_Missense_Mutation_p.R473L|CSTF2_uc004egi.2_Missense_Mutation_p.R436L	NM_001325	NP_001316	P33240	CSTF2_HUMAN	cleavage stimulation factor subunit 2	453	9.|12 X 5 AA tandem repeats of M-E-A-R-[AG].				mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cleavage body|mRNA cleavage and polyadenylation specificity factor complex	nucleotide binding|protein binding|protein binding|RNA binding			skin(1)	1						ATGGAGGCCCGTGCAATGGAA	0.612		NA											5	5					1.02e-07	1.73e-07	1	0
ESX1	80712	broad.mit.edu	37	X	103495025	103495025	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:103495025C>A	uc004ely.2	-	4	1163	c.1105G>T	c.(1105-1107)GGG>TGG	p.G369W		NM_153448	NP_703149	Q8N693	ESX1_HUMAN	extraembryonic, spermatogenesis, homeobox	369	15 X 9 AA tandem repeats of P-P-x-x-P-x- P-P-x.|14.				negative regulation of transcription, DNA-dependent|regulation of cell cycle	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						ATGGGCGGCCCGGGTGGCAGA	0.701		NA											11	11					0.000673444	0.0010017	1	0
TRPC5	7224	broad.mit.edu	37	X	111078301	111078301	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:111078301G>T	uc004epl.1	-	7	2663	c.1744C>A	c.(1744-1746)CTT>ATT	p.L582I	TRPC5_uc004epm.1_Missense_Mutation_p.L582I	NM_012471	NP_036603	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel,	582	Extracellular (Potential).				axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			urinary_tract(1)	1						AGATTTAAAAGGCCAAATACA	0.398		NA											110	65					1.94e-58	4.15e-58	1	0
ODZ1	10178	broad.mit.edu	37	X	123805537	123805537	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:123805537T>A	uc004euj.2	-	6	1228	c.1164A>T	c.(1162-1164)AAA>AAT	p.K388N	ODZ1_uc011muj.1_Missense_Mutation_p.K387N|ODZ1_uc010nqy.2_Missense_Mutation_p.K388N	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	388	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						CTGTACCTTTTTTCTCTGATT	0.373		NA											37	24					0	0	0	0
DCAF12L1	139170	broad.mit.edu	37	X	125686094	125686094	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:125686094G>T	uc004eul.2	-	1	749	c.498C>A	c.(496-498)ACC>ACA	p.T166T		NM_178470	NP_848565	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	166	WD 1.									skin(3)|ovary(1)	4						TTTCGCCGCCGGTGGCCAGAA	0.657		NA											22	7					3.62e-10	6.48e-10	1	0
GPR101	83550	broad.mit.edu	37	X	136112422	136112422	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:136112422T>A	uc011mwh.1	-	1	1412	c.1412A>T	c.(1411-1413)AAG>ATG	p.K471M		NM_054021	NP_473362	Q96P66	GP101_HUMAN	G protein-coupled receptor 101	471	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	Acute lymphoblastic leukemia(192;0.000127)					GCAGAAGAACTTCTTCAGCAT	0.493		NA											39	20					0	0	0	0
F9	2158	broad.mit.edu	37	X	138642993	138642993	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:138642993G>A	uc004fas.1	+	7	846	c.817G>A	c.(817-819)GTT>ATT	p.V273I	F9_uc004fat.1_Missense_Mutation_p.V235I	NM_000133	NP_000124	P00740	FA9_HUMAN	coagulation factor IX preproprotein	273	Peptidase S1.				blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen|plasma membrane	calcium ion binding|serine-type endopeptidase activity			lung(2)|ovary(1)	3	Acute lymphoblastic leukemia(192;0.000127)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Heparin(DB01109)|Menadione(DB00170)	TGAAACTGGTGTTAAAATTAC	0.368		NA											7	42					0	0	0	0
SPANXE	171489	broad.mit.edu	37	X	140785676	140785676	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:140785676G>T	uc004fbq.2	-	2	333	c.240C>A	c.(238-240)CTC>CTA	p.L80L		NM_145665	NP_663698	Q8TAD1	SPNXE_HUMAN	SPANX family, member E	80						cytoplasm|nucleus					0	Acute lymphoblastic leukemia(192;7.65e-05)					CCTCCATTTGGAGGGGGTTGA	0.443		NA											105	132					1.62e-62	3.48e-62	1	0
MAGEC2	51438	broad.mit.edu	37	X	141291747	141291747	+	Silent	SNP	G	G	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:141291747G>A	uc004fbu.1	-	3	375	c.27C>T	c.(25-27)TTC>TTT	p.F9F		NM_016249	NP_057333	Q9UBF1	MAGC2_HUMAN	melanoma antigen family C, 2	9						cytoplasm|nucleus				breast(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					CAACGTTGCGGAATGGAACGC	0.537		NA								HNSCC(46;0.14)			49	32					0	0	0	0
IDS	3423	broad.mit.edu	37	X	148564745	148564745	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:148564745C>A	uc011mxe.1	-	9	1383	c.1185G>T	c.(1183-1185)AGG>AGT	p.R395S	IDS_uc011mxd.1_5'UTR|IDS_uc011mxf.1_Missense_Mutation_p.R305S|IDS_uc011mxg.1_Missense_Mutation_p.R184S|IDS_uc010nsu.1_Missense_Mutation_p.R5S|IDS_uc004fcw.3_Missense_Mutation_p.R184S	NM_000202	NP_000193	P22304	IDS_HUMAN	iduronate-2-sulfatase isoform a precursor	395						lysosome	iduronate-2-sulfatase activity|metal ion binding				0	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)					CCATGGATTGCCTGCCTGAAA	0.532		NA											11	9					4.69e-08	7.99e-08	1	0
PASD1	139135	broad.mit.edu	37	X	150840977	150840977	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:150840977T>A	uc004fev.3	+	14	2092	c.1760T>A	c.(1759-1761)CTG>CAG	p.L587Q		NM_173493	NP_775764	Q8IV76	PASD1_HUMAN	PAS domain containing 1	587						nucleus	signal transducer activity			ovary(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					CAGATATGCCTGCAAAACCCA	0.348		NA											30	16					0	0	0	0
MAGEA4	4103	broad.mit.edu	37	X	151092986	151092986	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:151092986T>A	uc004fez.2	+	3	1006	c.850T>A	c.(850-852)TAT>AAT	p.Y284N	MAGEA4_uc004ffa.2_Missense_Mutation_p.Y284N|MAGEA4_uc004ffb.2_Missense_Mutation_p.Y284N|MAGEA4_uc004ffc.2_Missense_Mutation_p.Y284N|MAGEA4_uc004ffd.2_Missense_Mutation_p.Y284N	NM_002362	NP_002353	P43358	MAGA4_HUMAN	melanoma antigen family A, 4	284	MAGE.						protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					TGAAACCAGCTATGTGAAAGT	0.552		NA											85	59					0	0	0	0
DUSP9	1852	broad.mit.edu	37	X	152915660	152915660	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:152915660A>C	uc004fhx.3	+	4	1259	c.1055A>C	c.(1054-1056)CAG>CCG	p.Q352P	DUSP9_uc004fhy.3_Missense_Mutation_p.Q352P	NM_001395	NP_001386	Q99956	DUS9_HUMAN	dual specificity phosphatase 9	352	Tyrosine-protein phosphatase.				inactivation of MAPK activity|JNK cascade	cytosol|endoplasmic reticulum|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			ovary(2)	2	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CGCCACTCGCAGGAGCAGGGC	0.632		NA											40	36					0	0	0	0
AMELY	266	broad.mit.edu	37	Y	6736363	6736363	+	Silent	SNP	G	G	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrY:6736363G>T	uc004fra.1	-	5	342	c.330C>A	c.(328-330)GTC>GTA	p.V110V	AMELY_uc004fqz.2_Silent_p.V96V	NM_001143	NP_001134	Q99218	AMELY_HUMAN	amelogenin, Y-linked precursor	110	Gln-rich.				biomineral tissue development	proteinaceous extracellular matrix	structural constituent of tooth enamel				0						CTTGCTGGCGGACCCTGGGCT	0.612		NA											32	25					1.22e-17	2.43e-17	1	0
TBL1Y	90665	broad.mit.edu	37	Y	6958154	6958154	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrY:6958154C>A	uc004frb.2	+	18	2118	c.1471C>A	c.(1471-1473)CAA>AAA	p.Q491K	TBL1Y_uc004frc.2_Missense_Mutation_p.Q491K|TBL1Y_uc004frd.2_Missense_Mutation_p.Q491K|TBL1Y_uc011nap.1_Missense_Mutation_p.Q333K	NM_033284	NP_150600	Q9BQ87	TBL1Y_HUMAN	transducin beta-like 1Y	491	WD 8.				transcription, DNA-dependent						0						CCACAGCTACCAAGGCACTGG	0.532		NA											11	11					7.04e-09	1.22e-08	1	0
KDM5D	8284	broad.mit.edu	37	Y	21869833	21869833	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrY:21869833T>A	uc004fug.2	-	23	3674	c.3386A>T	c.(3385-3387)GAC>GTC	p.D1129V	KDM5D_uc011naz.1_Missense_Mutation_p.D1160V|KDM5D_uc010nwy.2_Missense_Mutation_p.D1072V|KDM5D_uc004fuf.2_Missense_Mutation_p.D304V	NM_004653	NP_004644	Q9BY66	KDM5D_HUMAN	jumonji, AT rich interactive domain 1D isoform	1129					chromatin modification|spermatogenesis	nucleus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			skin(1)	1					Vitamin C(DB00126)	AGAGCCTGGGTCTCTGAGGTC	0.577		NA											12	11					0	0	0	0
ELAVL4	1996	broad.mit.edu	37	1	50661318	50661319	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:50661318_50661319insA	uc001csb.2	+	5	862_863	c.594_595insA	c.(592-597)CCCAGCfs	p.P198fs	ELAVL4_uc001cry.3_Frame_Shift_Ins_p.P201fs|ELAVL4_uc001crz.3_Frame_Shift_Ins_p.P198fs|ELAVL4_uc001csa.3_Frame_Shift_Ins_p.P215fs|ELAVL4_uc001csc.3_Frame_Shift_Ins_p.P198fs|ELAVL4_uc009vyu.2_Frame_Shift_Ins_p.P203fs|ELAVL4_uc010omz.1_Frame_Shift_Ins_p.P203fs	NM_021952	NP_068771	P26378	ELAV4_HUMAN	ELAV-like 4 isoform 1	198_199	RRM 2.				mRNA processing		AU-rich element binding|mRNA 3'-UTR binding|nucleotide binding			ovary(1)|pancreas(1)	2						GCCAGAAGCCCAGCGGTGCTAC	0.569		NA											85	63	---	---	---	---	NA	NA	NA	NA
TXNIP	10628	broad.mit.edu	37	1	145439871	145439874	+	Frame_Shift_Del	DEL	AAAG	AAAG	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:145439871_145439874delAAAG	uc001enn.3	+	3	758_761	c.417_420delAAAG	c.(415-420)ACAAAGfs	p.T139fs	NBPF10_uc001emp.3_Intron|TXNIP_uc001enm.1_Intron|TXNIP_uc010oys.1_Frame_Shift_Del_p.T84fs	NM_006472	NP_006463	Q9H3M7	TXNIP_HUMAN	thioredoxin interacting protein	139_140					cell cycle|keratinocyte differentiation|transcription, DNA-dependent		ubiquitin protein ligase binding			ovary(2)	2	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CTCAAGAGACAAAGAAAAACTTTG	0.441		NA											33	78	---	---	---	---	NA	NA	NA	NA
NID1	4811	broad.mit.edu	37	1	236208939	236208939	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:236208939delG	uc001hxo.2	-	3	672	c.570delC	c.(568-570)TCCfs	p.S190fs	NID1_uc009xgd.2_Frame_Shift_Del_p.S190fs	NM_002508	NP_002499	P14543	NID1_HUMAN	nidogen 1 precursor	190	NIDO.				cell-matrix adhesion	basement membrane	calcium ion binding			large_intestine(1)|pancreas(1)	2	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	AAATGGCATAGGAGCTGGAAT	0.413		NA											15	35	---	---	---	---	NA	NA	NA	NA
PLD5	200150	broad.mit.edu	37	1	242253370	242253370	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr1:242253370delC	uc001hzn.1	-	10	1524	c.1397delG	c.(1396-1398)GGCfs	p.G466fs	PLD5_uc001hzl.3_Frame_Shift_Del_p.G404fs|PLD5_uc001hzm.3_Frame_Shift_Del_p.G256fs|PLD5_uc001hzo.1_Frame_Shift_Del_p.G374fs			Q8N7P1	PLD5_HUMAN	RecName: Full=Inactive phospholipase D5;          Short=Inactive PLD 5; AltName: Full=Inactive choline phosphatase 5; AltName: Full=Inactive phosphatidylcholine-hydrolyzing phospholipase D5; AltName: Full=PLDc;	466						integral to membrane	catalytic activity			ovary(6)	6	Melanoma(84;0.242)		OV - Ovarian serous cystadenocarcinoma(106;0.0329)			AAGGCCCGTGCCAGCATTCTG	0.423		NA											65	85	---	---	---	---	NA	NA	NA	NA
NHLRC2	374354	broad.mit.edu	37	10	115636695	115636695	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr10:115636695delG	uc001lax.1	+	3	959	c.747delG	c.(745-747)TTGfs	p.L249fs		NM_198514	NP_940916	Q8NBF2	NHLC2_HUMAN	NHL repeat containing 2	249	NHL 1.				cell redox homeostasis					ovary(1)	1				Epithelial(162;0.017)|all cancers(201;0.0187)		ATAGAATTTTGGTCGTTTGGA	0.358		NA											11	41	---	---	---	---	NA	NA	NA	NA
OR8K1	390157	broad.mit.edu	37	11	56114379	56114379	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:56114379delC	uc010rjg.1	+	1	865	c.865delC	c.(865-867)CCTfs	p.P289fs		NM_001002907	NP_001002907	Q8NGG5	OR8K1_HUMAN	olfactory receptor, family 8, subfamily K,	289	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2	Esophageal squamous(21;0.00448)					CCTGTTGATTCCTATGCTGAA	0.353		NA								HNSCC(65;0.19)			26	90	---	---	---	---	NA	NA	NA	NA
OR4D9	390199	broad.mit.edu	37	11	59282896	59282896	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr11:59282896delC	uc010rkv.1	+	1	511	c.511delC	c.(511-513)CCCfs	p.P171fs		NM_001004711	NP_001004711	Q8NGE8	OR4D9_HUMAN	olfactory receptor, family 4, subfamily D,	171	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TTTCTGTGGACCCAATGTTCT	0.532		NA											37	103	---	---	---	---	NA	NA	NA	NA
IRAK3	11213	broad.mit.edu	37	12	66638281	66638282	+	Frame_Shift_Ins	INS	-	-	GATGA			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:66638281_66638282insGATGA	uc001sth.2	+	9	1005_1006	c.903_904insGATGA	c.(901-906)TTGGATfs	p.L301fs	IRAK3_uc010ssy.1_Frame_Shift_Ins_p.L240fs	NM_007199	NP_009130	Q9Y616	IRAK3_HUMAN	interleukin-1 receptor-associated kinase 3	301_302	Protein kinase.				interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|negative regulation of innate immune response|negative regulation of interleukin-12 production|negative regulation of interleukin-6 production|negative regulation of macrophage cytokine production|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein catabolic process|negative regulation of protein complex disassembly|negative regulation of toll-like receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of macrophage tolerance induction|positive regulation of NF-kappaB transcription factor activity|response to exogenous dsRNA|response to lipopolysaccharide|response to peptidoglycan	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein heterodimerization activity|protein homodimerization activity|protein serine/threonine kinase activity			lung(3)|ovary(2)|breast(2)|central_nervous_system(1)	8				GBM - Glioblastoma multiforme(28;0.0203)		ACATCCTTTTGGATGATCAGTT	0.396		NA											10	48	---	---	---	---	NA	NA	NA	NA
TPH2	121278	broad.mit.edu	37	12	72335486	72335487	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:72335486_72335487insT	uc009zrw.1	+	2	369_370	c.228_229insT	c.(226-231)GGATTGfs	p.G76fs	TPH2_uc001swy.2_5'UTR	NM_173353	NP_775489	Q8IWU9	TPH2_HUMAN	tryptophan hydroxylase 2	76_77	ACT.				aromatic amino acid family metabolic process|hormone biosynthetic process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity			ovary(2)|central_nervous_system(1)|skin(1)	4					L-Tryptophan(DB00150)	AAGTTGGTGGATTGGTAAAAGC	0.416		NA											34	65	---	---	---	---	NA	NA	NA	NA
CMKLR1	1240	broad.mit.edu	37	12	108686440	108686440	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:108686440delG	uc009zuw.2	-	3	491	c.300delC	c.(298-300)GCCfs	p.A100fs	CMKLR1_uc001tmw.2_Frame_Shift_Del_p.A100fs|CMKLR1_uc001tmv.2_Frame_Shift_Del_p.A98fs|CMKLR1_uc009zuv.2_Frame_Shift_Del_p.A100fs	NM_001142345	NP_001135817	Q99788	CML1_HUMAN	chemokine-like receptor 1 isoform a	100	Extracellular (Potential).				chemotaxis|immune response|negative regulation of interleukin-12 production|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage chemotaxis|regulation of calcium-mediated signaling|skeletal system development	integral to plasma membrane	chemokine receptor activity			lung(3)|ovary(1)|pancreas(1)	5						GGTAGTCCATGGCGGCATAGG	0.498		NA											18	72	---	---	---	---	NA	NA	NA	NA
GLT1D1	144423	broad.mit.edu	37	12	129442110	129442110	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr12:129442110delG	uc010tbh.1	+	12	825	c.816delG	c.(814-816)CCGfs	p.P272fs	GLT1D1_uc001uhx.1_Frame_Shift_Del_p.P187fs|GLT1D1_uc001uhy.1_RNA	NM_144669	NP_653270	Q96MS3	GL1D1_HUMAN	glycosyltransferase 1 domain containing 1	267					biosynthetic process	extracellular region	transferase activity, transferring glycosyl groups				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.97e-06)|Epithelial(86;3.97e-05)|all cancers(50;0.00019)		TAGAAGTACCGGTATTGGCCA	0.527		NA											11	21	---	---	---	---	NA	NA	NA	NA
RB1	5925	broad.mit.edu	37	13	48955409	48955409	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr13:48955409delG	uc001vcb.2	+	17	1691	c.1525delG	c.(1525-1527)GGAfs	p.G509fs		NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	509	Domain A.|Pocket; binds T and E1A.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(7)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TCTTGATTCTGGAACAGATTT	0.294		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			10	11	---	---	---	---	NA	NA	NA	NA
GABRB3	2562	broad.mit.edu	37	15	26806276	26806276	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr15:26806276delC	uc001zaz.2	-	8	1025	c.883delG	c.(883-885)GAGfs	p.E295fs	GABRB3_uc010uae.1_Frame_Shift_Del_p.E210fs|GABRB3_uc001zba.2_Frame_Shift_Del_p.E295fs|GABRB3_uc001zbb.2_Frame_Shift_Del_p.E351fs	NM_000814	NP_000805	P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	295					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)|liver(1)|central_nervous_system(1)	5		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	GGCAAGGTCTCCCGAAGGTGG	0.473		NA											28	51	---	---	---	---	NA	NA	NA	NA
STRA6	64220	broad.mit.edu	37	15	74490147	74490147	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr15:74490147delG	uc002axk.2	-	3	308	c.126delC	c.(124-126)TCCfs	p.S42fs	STRA6_uc002axi.2_5'Flank|STRA6_uc010ulh.1_Frame_Shift_Del_p.S80fs|STRA6_uc002axj.2_Frame_Shift_Del_p.S81fs|STRA6_uc010bji.2_Frame_Shift_Del_p.S42fs|STRA6_uc002axl.2_5'UTR|STRA6_uc002axm.2_Frame_Shift_Del_p.S42fs|STRA6_uc002axn.2_Frame_Shift_Del_p.S42fs|STRA6_uc010uli.1_Frame_Shift_Del_p.S79fs|STRA6_uc010bjj.1_RNA|STRA6_uc010bjk.2_Frame_Shift_Del_p.S42fs	NM_022369	NP_071764	Q9BX79	STRA6_HUMAN	stimulated by retinoic acid gene 6 homolog	42	Extracellular (Potential).				adrenal gland development|alveolar primary septum development|developmental growth|diaphragm development|digestive tract morphogenesis|ear development|embryonic camera-type eye formation|embryonic digestive tract development|eyelid development in camera-type eye|face morphogenesis|feeding behavior|female genitalia development|kidney development|lung vasculature development|neuromuscular process|nose morphogenesis|paramesonephric duct development|positive regulation of behavior|pulmonary artery morphogenesis|pulmonary valve morphogenesis|smooth muscle tissue development|transport|uterus morphogenesis|ventricular septum development|vocal learning	integral to membrane|plasma membrane|protein complex	receptor activity			central_nervous_system(1)	1						TGGTGTGGCAGGAGGGCACTT	0.622		NA											15	25	---	---	---	---	NA	NA	NA	NA
APOB48R	55911	broad.mit.edu	37	16	28508798	28508798	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:28508798delG	uc002dqb.1	+	3	2419	c.2409delG	c.(2407-2409)GAGfs	p.E803fs	uc010vct.1_Intron|APOB48R_uc010byg.1_Frame_Shift_Del_p.E341fs	NM_018690	NP_061160	Q0VD83	APOBR_HUMAN	apolipoprotein B48 receptor	803	Glu-rich.				cholesterol metabolic process|lipid transport	chylomicron|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle					0						TTGGTCTGGAGGGCTCAGCAG	0.587		NA											8	49	---	---	---	---	NA	NA	NA	NA
CYLD	1540	broad.mit.edu	37	16	50811792	50811792	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr16:50811792delG	uc002egp.1	+	8	1493	c.1078delG	c.(1078-1080)GGGfs	p.G360fs	CYLD_uc002egn.1_Frame_Shift_Del_p.G357fs|CYLD_uc002ego.2_Frame_Shift_Del_p.G357fs|CYLD_uc010cbs.1_Frame_Shift_Del_p.G357fs|CYLD_uc002egq.1_Frame_Shift_Del_p.G357fs|CYLD_uc002egr.1_Frame_Shift_Del_p.G357fs|CYLD_uc002egs.1_Frame_Shift_Del_p.G357fs	NM_015247	NP_056062	Q9NQC7	CYLD_HUMAN	ubiquitin carboxyl-terminal hydrolase CYLD	360	Interaction with TRIP.				cell cycle|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K63-linked deubiquitination|regulation of microtubule cytoskeleton organization|regulation of mitotic cell cycle|translation|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	cytosol|extrinsic to internal side of plasma membrane|microtubule|perinuclear region of cytoplasm|ribosome	proline-rich region binding|protein kinase binding|structural constituent of ribosome|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			skin(19)|large_intestine(3)|haematopoietic_and_lymphoid_tissue(3)|central_nervous_system(3)	28		all_cancers(37;0.0156)				TACCTTAAATGGGTCTTCTGT	0.299		NA	Mis|N|F|S		cylindroma	cylindroma			Familial_Cylindromatosis|Multiple_Trichoepithelioma_Familial				41	47	---	---	---	---	NA	NA	NA	NA
RTN4RL1	146760	broad.mit.edu	37	17	1841024	1841025	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:1841024_1841025delCA	uc002ftp.2	-	2	110_111	c.91_92delTG	c.(91-93)TGCfs	p.C31fs		NM_178568	NP_848663	Q86UN2	R4RL1_HUMAN	reticulon 4 receptor-like 1 precursor	31	LRRNT.				axon regeneration	anchored to plasma membrane	receptor activity				0						CGCCGGGTAGCACACACAGTCC	0.658		NA											13	36	---	---	---	---	NA	NA	NA	NA
SLC16A3	9123	broad.mit.edu	37	17	80195732	80195732	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr17:80195732delG	uc002kea.2	+	4	1225	c.1086delG	c.(1084-1086)ATGfs	p.M362fs	SLC16A3_uc002kee.2_Frame_Shift_Del_p.M362fs|SLC16A3_uc002keb.2_Frame_Shift_Del_p.M362fs|SLC16A3_uc002kec.2_Frame_Shift_Del_p.M362fs|SLC16A3_uc002ked.2_Frame_Shift_Del_p.M362fs	NM_001042422	NP_001035887	O15427	MOT4_HUMAN	solute carrier family 16, member 3	362	Helical; (Potential).				blood coagulation|leukocyte migration|organic anion transport|pyruvate metabolic process	actin cytoskeleton|integral to plasma membrane|membrane fraction|nuclear membrane	secondary active monocarboxylate transmembrane transporter activity|symporter activity			upper_aerodigestive_tract(1)|lung(1)	2	Breast(20;0.00285)|all_neural(118;0.0804)|Lung NSC(278;0.128)|all_lung(278;0.145)|Ovarian(332;0.227)		OV - Ovarian serous cystadenocarcinoma(97;0.00463)|BRCA - Breast invasive adenocarcinoma(99;0.0149)		Pyruvic acid(DB00119)	TGCTGCTGATGGAGGCGGTGG	0.682		NA											10	30	---	---	---	---	NA	NA	NA	NA
ANKRD30B	374860	broad.mit.edu	37	18	14752966	14752966	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:14752966delG	uc010dlo.2	+	3	645	c.465delG	c.(463-465)GTGfs	p.V155fs	ANKRD30B_uc010xak.1_RNA	NM_001145029	NP_001138501	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	155	ANK 3.									ovary(1)|skin(1)	2						TGTTAATGGTGGCAACACTGC	0.363		NA											10	31	---	---	---	---	NA	NA	NA	NA
ASXL3	80816	broad.mit.edu	37	18	31319219	31319219	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr18:31319219delC	uc010dmg.1	+	11	1906	c.1851delC	c.(1849-1851)AGCfs	p.S617fs	ASXL3_uc002kxq.2_Frame_Shift_Del_p.S324fs	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	617	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						CTTCTGAGAGCCCAGAGGGAG	0.473		NA											15	13	---	---	---	---	NA	NA	NA	NA
MAST1	22983	broad.mit.edu	37	19	12951880	12951880	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:12951880delG	uc002mvm.2	+	3	376	c.248delG	c.(247-249)AGGfs	p.R83fs	MAST1_uc002mvk.2_Frame_Shift_Del_p.R79fs|MAST1_uc002mvl.2_Frame_Shift_Del_p.S83fs	NM_014975	NP_055790	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase	83					cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|large_intestine(1)|skin(1)	7						TCCTCCCGAAGGTGAGTCCCT	0.637		NA											25	67	---	---	---	---	NA	NA	NA	NA
CYP4F22	126410	broad.mit.edu	37	19	15651434	15651434	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:15651434delG	uc002nbh.3	+	8	1012	c.845delG	c.(844-846)CGGfs	p.R282fs		NM_173483	NP_775754	Q6NT55	CP4FN_HUMAN	cytochrome P450, family 4, subfamily F,	282						endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			ovary(1)|pancreas(1)	2						ATCCAGGAACGGCGGCGGGCA	0.617		NA											33	70	---	---	---	---	NA	NA	NA	NA
ZNF99	7652	broad.mit.edu	37	19	22941185	22941186	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:22941185_22941186insA	uc010xrh.1	-	5	1252_1253	c.1252_1253insT	c.(1252-1254)TGCfs	p.C418fs		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TTCACATTTGCAAGGTTTCTCT	0.351		NA											19	67	---	---	---	---	NA	NA	NA	NA
TTYH1	57348	broad.mit.edu	37	19	54933436	54933436	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr19:54933436delC	uc002qfq.2	+	4	582	c.490delC	c.(490-492)CCGfs	p.P164fs	TTYH1_uc010yey.1_Frame_Shift_Del_p.P213fs|TTYH1_uc002qfr.2_Frame_Shift_Del_p.P164fs|TTYH1_uc002qft.2_Frame_Shift_Del_p.P164fs|TTYH1_uc002qfu.1_Frame_Shift_Del_p.P76fs	NM_020659	NP_065710	Q9H313	TTYH1_HUMAN	tweety 1 isoform 1	164	Extracellular (Potential).				cell adhesion	chloride channel complex|plasma membrane	chloride channel activity|iron ion transmembrane transporter activity				0	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0767)		GGTGCTCGAGCCGCGCACGGA	0.716		NA											3	6	---	---	---	---	NA	NA	NA	NA
OTX1	5013	broad.mit.edu	37	2	63283445	63283446	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:63283445_63283446insT	uc002scd.2	+	5	1307_1308	c.1059_1060insT	c.(1057-1062)GTCTTGfs	p.V353fs	OTX1_uc010ypt.1_Frame_Shift_Ins_p.V287fs	NM_014562	NP_055377	P32242	OTX1_HUMAN	orthodenticle homeobox 1	353_354						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			pancreas(2)	2	Lung NSC(7;0.121)|all_lung(7;0.211)					GGTTCCAGGTCTTGTGAGCCCA	0.604		NA											15	42	---	---	---	---	NA	NA	NA	NA
ANXA4	307	broad.mit.edu	37	2	70015233	70015233	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:70015233delG	uc002sfr.3	+	3	284	c.57delG	c.(55-57)ATGfs	p.M19fs	ANXA4_uc010yqn.1_RNA|ANXA4_uc002sfs.3_Frame_Shift_Del_p.M19fs|ANXA4_uc010yqo.1_Intron	NM_001153	NP_001144	P09525	ANXA4_HUMAN	annexin IV	17					anti-apoptosis|signal transduction	cytoplasm	calcium ion binding|calcium-dependent phospholipid binding|phospholipase inhibitor activity				0						TCAATGCCATGGAAGATGCCC	0.532		NA											33	90	---	---	---	---	NA	NA	NA	NA
ERBB4	2066	broad.mit.edu	37	2	212812196	212812196	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr2:212812196delC	uc002veg.1	-	3	478	c.380delG	c.(379-381)GGAfs	p.G127fs	ERBB4_uc002veh.1_Frame_Shift_Del_p.G127fs|ERBB4_uc010zji.1_Frame_Shift_Del_p.G127fs|ERBB4_uc010zjj.1_Frame_Shift_Del_p.G127fs|ERBB4_uc010fut.1_Frame_Shift_Del_p.G127fs	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	127	Extracellular (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		TCCAAAGTTTCCATCTTTTCT	0.338		NA								TSP Lung(8;0.080)			15	29	---	---	---	---	NA	NA	NA	NA
ZXDC	79364	broad.mit.edu	37	3	126178522	126178522	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:126178522delT	uc003eiv.2	-	7	2240	c.2186delA	c.(2185-2187)AAGfs	p.K729fs	ZXDC_uc010hsh.2_Intron|ZXDC_uc003eix.2_3'UTR	NM_025112	NP_079388	Q2QGD7	ZXDC_HUMAN	ZXD family zinc finger C isoform 1	729					positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|LRR domain binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.155)		TCCTCTCTGCTTTTTTTCCTT	0.522		NA											8	878	---	---	---	---	NA	NA	NA	NA
PLCH1	23007	broad.mit.edu	37	3	155303945	155303945	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:155303945delC	uc011bok.1	-	4	750	c.473delG	c.(472-474)GGTfs	p.G158fs	PLCH1_uc011boj.1_Frame_Shift_Del_p.G158fs|PLCH1_uc011bol.1_Frame_Shift_Del_p.G140fs	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	158	Potential.|EF-hand 1.				lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			CAAGCCGTCACCATTCTTATC	0.403		NA											24	88	---	---	---	---	NA	NA	NA	NA
SPATA16	83893	broad.mit.edu	37	3	172607391	172607392	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:172607391_172607392insT	uc003fin.3	-	11	1836_1837	c.1678_1679insA	c.(1678-1680)ATGfs	p.M560fs		NM_031955	NP_114161	Q9BXB7	SPT16_HUMAN	spermatogenesis associated 16	560					cell differentiation|multicellular organismal development|spermatogenesis	Golgi apparatus	binding			ovary(2)|skin(1)	3	Ovarian(172;0.00319)|Breast(254;0.197)		LUSC - Lung squamous cell carcinoma(14;1.48e-14)|Lung(28;6.63e-14)			AAGTCGCTTCATTTTTGTTTTT	0.401		NA											7	273	---	---	---	---	NA	NA	NA	NA
SPATA16	83893	broad.mit.edu	37	3	172607397	172607397	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr3:172607397delG	uc003fin.3	-	11	1831	c.1673delC	c.(1672-1674)ACAfs	p.T558fs		NM_031955	NP_114161	Q9BXB7	SPT16_HUMAN	spermatogenesis associated 16	558					cell differentiation|multicellular organismal development|spermatogenesis	Golgi apparatus	binding			ovary(2)|skin(1)	3	Ovarian(172;0.00319)|Breast(254;0.197)		LUSC - Lung squamous cell carcinoma(14;1.48e-14)|Lung(28;6.63e-14)			CTTCATTTTTGTTTTTTGCCT	0.388		NA											7	254	---	---	---	---	NA	NA	NA	NA
GAK	2580	broad.mit.edu	37	4	860744	860745	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:860744_860745insA	uc003gbm.3	-	21	3070_3071	c.2871_2872insT	c.(2869-2874)GCTGCTfs	p.A957fs	GAK_uc003gbn.3_Frame_Shift_Ins_p.A878fs|GAK_uc010ibk.1_3'UTR|GAK_uc010ibi.2_Frame_Shift_Ins_p.A138fs|GAK_uc010ibj.2_RNA|GAK_uc003gbl.3_Frame_Shift_Ins_p.A821fs	NM_005255	NP_005246	O14976	GAK_HUMAN	cyclin G associated kinase	957_958					cell cycle	focal adhesion|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|heat shock protein binding|protein serine/threonine kinase activity			lung(2)|central_nervous_system(1)|skin(1)	4				Colorectal(103;0.219)		AAACACGTACCAGCGGCAGGGG	0.629		NA											45	106	---	---	---	---	NA	NA	NA	NA
KIT	3815	broad.mit.edu	37	4	55598063	55598063	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr4:55598063delC	uc010igr.2	+	16	2347	c.2260delC	c.(2260-2262)CCCfs	p.P754fs	KIT_uc010igs.2_Frame_Shift_Del_p.P750fs	NM_000222	NP_000213	P10721	KIT_HUMAN	v-kit Hardy-Zuckerman 4 feline sarcoma viral	754	Protein kinase.|Cytoplasmic (Potential).				male gonad development|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular space|integral to membrane	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity			soft_tissue(3273)|haematopoietic_and_lymphoid_tissue(1572)|skin(99)|testis(49)|bone(21)|genital_tract(18)|kidney(17)|ovary(16)|salivary_gland(15)|large_intestine(11)|thymus(6)|lung(6)|central_nervous_system(4)|NS(3)|eye(2)|endometrium(2)|breast(1)|stomach(1)|autonomic_ganglia(1)|pancreas(1)	5118	all_cancers(7;0.00453)|all_lung(4;0.000565)|Lung NSC(11;0.00129)|all_epithelial(27;0.0104)|Glioma(25;0.08)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(32;0.000276)|Epithelial(7;0.209)	Colorectal(1;0.0276)|COAD - Colon adenocarcinoma(1;0.171)	Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	AGATGTGACTCCCGCCATCAT	0.468		1	Mis|O		GIST|AML|TGCT|mastocytosis|mucosal melanoma	GIST|epithelioma	Piebald trait		Mast_Cell_disease_Familial_Clustering_of|Piebaldism|Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Gastrointestinal_Stromal_Tumors				26	96	---	---	---	---	NA	NA	NA	NA
ZNF608	57507	broad.mit.edu	37	5	123983092	123983092	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:123983092delG	uc003ktq.1	-	4	3108	c.2985delC	c.(2983-2985)CCCfs	p.P995fs	ZNF608_uc003ktr.1_Intron|ZNF608_uc003kts.1_Frame_Shift_Del_p.P995fs|ZNF608_uc003ktt.1_Frame_Shift_Del_p.P995fs|ZNF608_uc003ktp.1_5'Flank	NM_020747	NP_065798	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	995	Ser-rich.					intracellular	zinc ion binding			skin(3)|ovary(2)|lung(1)	6		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		TGTGGTAATAGGGAGAATGGG	0.463		NA											43	107	---	---	---	---	NA	NA	NA	NA
NSD1	64324	broad.mit.edu	37	5	176675254	176675254	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr5:176675254delG	uc003mfr.3	+	11	4708	c.4570delG	c.(4570-4572)GGGfs	p.G1524fs	NSD1_uc003mft.3_Frame_Shift_Del_p.G1255fs|NSD1_uc003mfs.1_Frame_Shift_Del_p.G1421fs|NSD1_uc011dfx.1_Frame_Shift_Del_p.G1172fs	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1524					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		ACACGATCCCGGGATGCCTGC	0.493		NA	T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			10	21	---	---	---	---	NA	NA	NA	NA
PRIM2	5558	broad.mit.edu	37	6	57512607	57512607	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr6:57512607delA	uc003pdx.2	+	15	1522	c.1435delA	c.(1435-1437)AAAfs	p.K479fs		NM_000947	NP_000938	P49643	PRI2_HUMAN	DNA primase polypeptide 2	479					DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	4 iron, 4 sulfur cluster binding|DNA binding|DNA primase activity|metal ion binding				0				Colorectal(6;0.041)|READ - Rectum adenocarcinoma(7;0.193)		AAGTGTCCAGAAAACCAAGGA	0.403		NA											49	603	---	---	---	---	NA	NA	NA	NA
ESCO2	157570	broad.mit.edu	37	8	27641568	27641569	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr8:27641568_27641569insA	uc003xgg.2	+	5	1090_1091	c.1007_1008insA	c.(1006-1008)TCAfs	p.S336fs	ESCO2_uc010luy.1_Intron	NM_001017420	NP_001017420	Q56NI9	ESCO2_HUMAN	establishment of cohesion 1 homolog 2	336					cell cycle|post-translational protein acetylation|regulation of DNA replication	chromatin|nucleus	acyltransferase activity|metal ion binding			central_nervous_system(1)	1		Ovarian(32;0.000953)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0204)|KIRC - Kidney renal clear cell carcinoma(542;0.0955)|Kidney(114;0.115)|Colorectal(74;0.132)		TCAGTCAATTCAAAAAGGTGAG	0.351		NA							SC_Phocomelia_syndrome				12	49	---	---	---	---	NA	NA	NA	NA
C9orf131	138724	broad.mit.edu	37	9	35044685	35044686	+	Frame_Shift_Ins	INS	-	-	C			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chr9:35044685_35044686insC	uc003zvw.2	+	2	2088_2089	c.2059_2060insC	c.(2059-2061)GCCfs	p.A687fs	C9orf131_uc003zvu.2_Frame_Shift_Ins_p.A639fs|C9orf131_uc003zvv.2_Frame_Shift_Ins_p.A614fs|C9orf131_uc003zvx.2_Frame_Shift_Ins_p.A652fs	NM_203299	NP_976044	Q5VYM1	CI131_HUMAN	hypothetical protein LOC138724 isoform A	687											0	all_epithelial(49;0.22)		LUSC - Lung squamous cell carcinoma(32;0.00117)|Lung(28;0.00309)			TGAGCTCCCAGCCCCCAGCTCA	0.54		NA											17	55	---	---	---	---	NA	NA	NA	NA
DMD	1756	broad.mit.edu	37	X	31198490	31198490	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:31198490delA	uc004dda.1	-	69	10327	c.10083delT	c.(10081-10083)ACTfs	p.T3361fs	DMD_uc004dcq.1_Frame_Shift_Del_p.T632fs|DMD_uc004dcr.1_Frame_Shift_Del_p.T901fs|DMD_uc004dcs.1_Frame_Shift_Del_p.T901fs|DMD_uc004dct.1_Frame_Shift_Del_p.T901fs|DMD_uc004dcu.1_Frame_Shift_Del_p.T901fs|DMD_uc004dcv.1_Frame_Shift_Del_p.T901fs|DMD_uc004dcw.2_Frame_Shift_Del_p.T2017fs|DMD_uc004dcx.2_Frame_Shift_Del_p.T2020fs|DMD_uc004dcz.2_Frame_Shift_Del_p.T3238fs|DMD_uc004dcy.1_Frame_Shift_Del_p.T3357fs|DMD_uc004ddb.1_Frame_Shift_Del_p.T3353fs|DMD_uc004dcm.1_Frame_Shift_Del_p.T293fs|DMD_uc004dcn.1_Frame_Shift_Del_p.T293fs|DMD_uc004dco.1_Frame_Shift_Del_p.T293fs|DMD_uc004dcp.1_Frame_Shift_Del_p.T293fs|DMD_uc011mkb.1_Frame_Shift_Del_p.T293fs|DMD_uc010ngm.2_Frame_Shift_Del_p.T293fs	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	3361	Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				AACTTACCGGAGTGCAATATT	0.408		NA											9	12	---	---	---	---	NA	NA	NA	NA
ZMYM3	9203	broad.mit.edu	37	X	70469326	70469327	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:70469326_70469327insT	uc004dzh.1	-	7	1541_1542	c.1454_1455insA	c.(1453-1455)TTGfs	p.L485fs	BCYRN1_uc011mpt.1_Intron|ZMYM3_uc004dzi.1_Frame_Shift_Ins_p.L485fs|ZMYM3_uc004dzj.1_Frame_Shift_Ins_p.L485fs|ZMYM3_uc011mpu.1_Frame_Shift_Ins_p.L216fs|ZMYM3_uc004dzk.3_Frame_Shift_Ins_p.L485fs|ZMYM3_uc004dzl.3_Frame_Shift_Ins_p.L485fs|ZMYM3_uc004dzm.3_Frame_Shift_Ins_p.L485fs	NM_201599	NP_963893	Q14202	ZMYM3_HUMAN	zinc finger protein 261	485	MYM-type 4.				multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Renal(35;0.156)					TGTACGCCCCCAAGCAGGTTGT	0.564		NA											6	7	---	---	---	---	NA	NA	NA	NA
L1CAM	3897	broad.mit.edu	37	X	153132315	153132315	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CR-7402-01A-11D-2012-08	TCGA-CR-7402-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	015b1cc4-6fa5-43c1-9444-4a1af7663f7e	c9ec8ba4-bfa2-4054-82e0-06344d3023e1	g.chrX:153132315delC	uc004fjb.2	-	18	2328	c.2220delG	c.(2218-2220)TGGfs	p.W740fs	L1CAM_uc004fjc.2_Frame_Shift_Del_p.W740fs|L1CAM_uc010nuo.2_Frame_Shift_Del_p.W735fs	NM_000425	NP_000416	P32004	L1CAM_HUMAN	L1 cell adhesion molecule isoform 1 precursor	740	Extracellular (Potential).|Fibronectin type-III 2.				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				ovary(8)|central_nervous_system(1)	9	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TCCAGTCCATCCACCGGAGCG	0.652		NA											25	17	---	---	---	---	NA	NA	NA	NA