Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
DNAJC11	55735	broad.mit.edu	37	1	6738499	6738499	+	Silent	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:6738499G>A	uc001aof.2	-	3	337	c.231C>T	c.(229-231)ATC>ATT	p.I77I	DNAJC11_uc010nzt.1_Silent_p.I39I|DNAJC11_uc001aog.2_Silent_p.I77I|DNAJC11_uc010nzu.1_Intron	NM_018198	NP_060668	Q9NVH1	DJC11_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 11	77	J.				protein folding		heat shock protein binding|unfolded protein binding			ovary(1)|skin(1)	2	Ovarian(185;0.0265)|all_lung(157;0.154)	all_cancers(23;1.97e-27)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;2.34e-07)|COAD - Colon adenocarcinoma(227;2.05e-05)|Kidney(185;7.67e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000639)|KIRC - Kidney renal clear cell carcinoma(229;0.00128)|STAD - Stomach adenocarcinoma(132;0.00179)|READ - Rectum adenocarcinoma(331;0.0649)		ATATATCATAGATGGCCCTGG	0.388		NA											11	48					0	0	0	0
SLC2A7	155184	broad.mit.edu	37	1	9067373	9067373	+	Silent	SNP	C	C	T			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:9067373C>T	uc009vmo.1	-	10	1188	c.1188G>A	c.(1186-1188)GGG>GGA	p.G396G		NM_207420	NP_997303	Q6PXP3	GTR7_HUMAN	intestinal facilitative glucose transporter 7	396	Helical; (Potential).					integral to membrane|plasma membrane	sugar transmembrane transporter activity				0	Ovarian(185;0.112)|all_lung(157;0.185)	all_epithelial(116;1.34e-15)|all_lung(118;9.46e-05)|Lung NSC(185;0.000172)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.00715)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.04e-07)|COAD - Colon adenocarcinoma(227;7.66e-05)|Kidney(185;0.000249)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.00177)|BRCA - Breast invasive adenocarcinoma(304;0.00185)|READ - Rectum adenocarcinoma(331;0.0642)		ACTCACTGGGCCCAATGGAAT	0.433		NA											4	53					0	0	0	0
ZBTB17	7709	broad.mit.edu	37	1	16273491	16273491	+	Silent	SNP	G	G	C			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:16273491G>C	uc001axl.3	-	4	572	c.333C>G	c.(331-333)CTC>CTG	p.L111L	ZBTB17_uc010obq.1_Nonsense_Mutation_p.S21*|ZBTB17_uc010obr.1_Silent_p.L111L|ZBTB17_uc010obs.1_Silent_p.L35L|ZBTB17_uc010obt.1_Intron|ZBTB17_uc010obu.1_Silent_p.L35L|ZBTB17_uc009vom.1_Intron|ZBTB17_uc010obv.1_Silent_p.L111L	NM_003443	NP_003434	Q13105	ZBT17_HUMAN	zinc finger and BTB domain containing 17	111					negative regulation of cell cycle	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(325;0.000257)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|Colorectal(212;4.12e-07)|COAD - Colon adenocarcinoma(227;2.43e-05)|BRCA - Breast invasive adenocarcinoma(304;9.97e-05)|Kidney(64;0.000182)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0649)		CAAGTGACTTGAGGGCATGGC	0.602		NA											8	45					0	0	0	0
HSPG2	3339	broad.mit.edu	37	1	22170783	22170783	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:22170783C>T	uc001bfj.2	-	65	8514	c.8474G>A	c.(8473-8475)GGA>GAA	p.G2825E	HSPG2_uc009vqd.2_Missense_Mutation_p.G2826E	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	2825	Ig-like C2-type 13.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	GGGTGGGGCTCCACCTGGGGC	0.682		NA											10	67					0	0	0	0
XKR8	55113	broad.mit.edu	37	1	28293631	28293631	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:28293631C>A	uc001bph.1	+	3	1185	c.1108C>A	c.(1108-1110)CAG>AAG	p.Q370K		NM_018053	NP_060523	Q9H6D3	XKR8_HUMAN	XK, Kell blood group complex subunit-related	370						integral to membrane					0		Colorectal(325;0.000147)|Renal(390;0.00357)|Lung NSC(340;0.00588)|all_lung(284;0.00645)|Breast(348;0.0174)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0545)|all_neural(195;0.0557)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;4.72e-24)|Colorectal(126;1.52e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00269)|STAD - Stomach adenocarcinoma(196;0.00303)|BRCA - Breast invasive adenocarcinoma(304;0.00572)|READ - Rectum adenocarcinoma(331;0.0526)		TCAGCTGCCTCAGAACAGGCG	0.577		NA											10	71					9.7e-10	1.07e-09	1	0
SERINC2	347735	broad.mit.edu	37	1	31897634	31897634	+	Silent	SNP	C	C	T	rs35593581	byFrequency	TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:31897634C>T	uc010ogh.1	+	3	519	c.318C>T	c.(316-318)TTC>TTT	p.F106F	SERINC2_uc010ogg.1_Silent_p.F103F|SERINC2_uc009vtw.1_Silent_p.F102F|SERINC2_uc001bst.2_Silent_p.F102F|SERINC2_uc001bsu.2_Silent_p.F47F|SERINC2_uc001bsv.2_Silent_p.F47F	NM_178865	NP_849196	Q96SA4	SERC2_HUMAN	tumor differentially expressed 2-like	102	Helical; (Potential).					integral to membrane					0		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0629)|Breast(348;0.0707)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0541)|READ - Rectum adenocarcinoma(331;0.151)		GCATGTGCTTCGCCACGGCGG	0.657		NA											3	22					0	0	0	0
COL16A1	1307	broad.mit.edu	37	1	32165443	32165443	+	Silent	SNP	C	C	T			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:32165443C>T	uc001btk.1	-	4	602	c.237G>A	c.(235-237)CTG>CTA	p.L79L	COL16A1_uc001btj.1_5'Flank|COL16A1_uc001btl.3_Silent_p.L79L	NM_001856	NP_001847	Q07092	COGA1_HUMAN	alpha 1 type XVI collagen precursor	79	TSP N-terminal.				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			ovary(8)	8		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		GGGCCGCCCCCAGGCGCAGGA	0.592		NA											14	83					0	0	0	0
INPP5B	3633	broad.mit.edu	37	1	38345771	38345771	+	Silent	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:38345771G>A	uc001ccg.1	-	15	1621	c.1527C>T	c.(1525-1527)GAC>GAT	p.D509D	INPP5B_uc009vvk.1_Silent_p.D450D|INPP5B_uc001ccf.1_Silent_p.D345D|INPP5B_uc010oij.1_RNA	NM_005540	NP_005531	P32019	I5P2_HUMAN	inositol polyphosphate-5-phosphatase, 75kDa	589				GSDDWDTSEKCRAPAWCDRI -> RALTTGIPVRSAVLLPG VIGF (in Ref. 5; AA sequence).	regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to membrane|microtubule cytoskeleton	GTPase activator activity|inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			urinary_tract(1)	1	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				TATCCCAGTCGTCAGAGCCCG	0.478		NA											19	78					0	0	0	0
IPO13	9670	broad.mit.edu	37	1	44422118	44422118	+	Silent	SNP	C	C	T			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:44422118C>T	uc001ckx.2	+	3	1743	c.948C>T	c.(946-948)GGC>GGT	p.G316G		NM_014652	NP_055467	O94829	IPO13_HUMAN	importin 13	316					protein import into nucleus	cytoplasm|nucleus	protein binding|protein transporter activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				TGGCCCTGGGCGAGAACCACT	0.597		NA											16	52					0	0	0	0
UROD	7389	broad.mit.edu	37	1	45480410	45480410	+	Silent	SNP	C	C	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:45480410C>A	uc001cna.1	+	8	885	c.777C>A	c.(775-777)ATC>ATA	p.I259I	UROD_uc001cnb.1_Silent_p.I224I|UROD_uc010olj.1_3'UTR|UROD_uc001cnc.1_Silent_p.I164I	NM_000374	NP_000365	P06132	DCUP_HUMAN	uroporphyrinogen decarboxylase	259						cytosol|microtubule cytoskeleton|nucleus	uroporphyrinogen decarboxylase activity				0	Acute lymphoblastic leukemia(166;0.155)					TTTTCTAGATCATCTTTGCTA	0.527		NA							Porphyria_Cutanea_Tarda_Type_II		OREG0013449	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	33					0.00909568	0.00940813	1	0
MUTYH	4595	broad.mit.edu	37	1	45797203	45797203	+	Silent	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:45797203G>A	uc001cnm.2	-	13	1419	c.1203C>T	c.(1201-1203)TTC>TTT	p.F401F	MUTYH_uc009vxn.2_Silent_p.F226F|MUTYH_uc001cnf.2_Silent_p.F376F|MUTYH_uc009vxo.2_Silent_p.F376F|MUTYH_uc001cng.2_Silent_p.F387F|MUTYH_uc001cnj.2_Silent_p.F284F|MUTYH_uc001cni.2_Silent_p.F376F|MUTYH_uc001cnh.2_Silent_p.F377F|MUTYH_uc001cno.2_Silent_p.F284F|MUTYH_uc001cnk.2_Silent_p.F261F|MUTYH_uc010oll.1_Silent_p.F85F|MUTYH_uc001cnl.2_Silent_p.F390F|MUTYH_uc009vxp.2_Silent_p.F404F|MUTYH_uc001cnn.2_Silent_p.F391F	NM_012222	NP_036354	Q9UIF7	MUTYH_HUMAN	mutY homolog isoform 1	401	Nudix hydrolase.				depurination|mismatch repair	nucleoplasm	4 iron, 4 sulfur cluster binding|DNA N-glycosylase activity|endonuclease activity|metal ion binding|MutSalpha complex binding				0	Acute lymphoblastic leukemia(166;0.155)					TCACGGACGGGAACTCCCACA	0.657		NA	Mis			colorectal		BER_DNA_glycosylases	MUTYH-associated_polyposis				15	56					0	0	0	0
TACSTD2	4070	broad.mit.edu	37	1	59042150	59042150	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:59042150C>T	uc001cyz.3	-	1	1017	c.679G>A	c.(679-681)GAG>AAG	p.E227K		NM_002353	NP_002344	P09758	TACD2_HUMAN	tumor-associated calcium signal transducer 2	227	Extracellular (Potential).				cell proliferation|cell surface receptor linked signaling pathway|visual perception	cytosol|integral to plasma membrane	receptor activity				0	all_cancers(7;6.54e-05)					ATGTCCCTCTCGAAGTAGTAG	0.632		NA											4	20					0	0	0	0
KIAA1324	57535	broad.mit.edu	37	1	109714534	109714534	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:109714534G>A	uc001dwq.2	+	5	650	c.514G>A	c.(514-516)GAA>AAA	p.E172K	KIAA1324_uc009wex.1_Missense_Mutation_p.E172K|KIAA1324_uc009wey.2_Missense_Mutation_p.E172K|KIAA1324_uc010ovg.1_Missense_Mutation_p.E70K	NM_020775	NP_065826	Q6UXG2	K1324_HUMAN	hypothetical protein LOC57535 precursor	172	Extracellular (Potential).				macroautophagy|positive regulation of vacuole organization|regulation of apoptosis	integral to plasma membrane				ovary(2)|haematopoietic_and_lymphoid_tissue(1)|breast(1)|skin(1)	5		all_epithelial(167;0.000102)|all_lung(203;0.000323)|Lung NSC(277;0.00063)		Colorectal(144;0.0188)|Lung(183;0.0527)|COAD - Colon adenocarcinoma(174;0.14)|Epithelial(280;0.21)|all cancers(265;0.249)		CAACACGGACGAATGCACAGC	0.532		NA											17	71					0	0	0	0
CELSR2	1952	broad.mit.edu	37	1	109815344	109815344	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:109815344C>A	uc001dxa.3	+	30	8198	c.8137C>A	c.(8137-8139)CAG>AAG	p.Q2713K		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	2713	Cytoplasmic (Potential).				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		TCAAGACCAGCAGCATGGTGA	0.622		NA											12	50					0.000978159	0.00103547	1	0
LRIG2	9860	broad.mit.edu	37	1	113657144	113657144	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:113657144C>T	uc001edf.1	+	15	2374	c.2176C>T	c.(2176-2178)CGT>TGT	p.R726C	LRIG2_uc009wgn.1_Missense_Mutation_p.R623C	NM_014813	NP_055628	O94898	LRIG2_HUMAN	leucine-rich repeats and immunoglobulin-like	726	Ig-like C2-type 3.|Extracellular (Potential).					cytoplasm|integral to membrane|plasma membrane				ovary(3)	3	Lung SC(450;0.246)	all_cancers(81;1.56e-05)|all_epithelial(167;2.62e-05)|all_lung(203;0.000665)|Lung NSC(69;0.000986)		Lung(183;0.0279)|Colorectal(144;0.0885)|COAD - Colon adenocarcinoma(174;0.134)|all cancers(265;0.139)|Epithelial(280;0.143)|LUSC - Lung squamous cell carcinoma(189;0.15)		TCCTGCCCCTCGTCTCAACTG	0.498		NA											11	70					0	0	0	0
VPS45	11311	broad.mit.edu	37	1	150040002	150040002	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:150040002G>C	uc001etp.2	+	1	661	c.88G>C	c.(88-90)GAG>CAG	p.E30Q	VPS45_uc010pbp.1_RNA|VPS45_uc010pbq.1_5'UTR|VPS45_uc010pbs.1_Intron|VPS45_uc009wlm.1_Missense_Mutation_p.E30Q|VPS45_uc010pbr.1_Intron	NM_007259	NP_009190	Q9NRW7	VPS45_HUMAN	vacuolar protein sorting 45A	30					blood coagulation|intracellular protein transport|vesicle docking involved in exocytosis	endosome membrane|Golgi membrane|integral to membrane of membrane fraction				central_nervous_system(1)|skin(1)	2	Breast(34;0.00211)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			CATGGATAAAGAGACGGTGAG	0.433		NA											4	49					0	0	0	0
FLG	2312	broad.mit.edu	37	1	152284258	152284258	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:152284258G>C	uc001ezu.1	-	3	3140	c.3104C>G	c.(3103-3105)TCC>TGC	p.S1035C	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1035	Filaggrin 6.|Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGGTGGCGGGATCCGTGTCT	0.567		NA							Ichthyosis				41	651					0	0	0	0
LCE2C	353140	broad.mit.edu	37	1	152648718	152648718	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:152648718A>G	uc001fah.2	+	2	282	c.227A>G	c.(226-228)CAC>CGC	p.H76R		NM_178429	NP_848516	Q5TA81	LCE2C_HUMAN	late cornified envelope 2C	76	Cys-rich.				keratinization						0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGAGCCACCACAGGCCCCGT	0.682		NA											4	143					0	0	0	0
PEA15	8682	broad.mit.edu	37	1	160181434	160181434	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:160181434G>A	uc001fvk.2	+	2	290	c.100G>A	c.(100-102)GAA>AAA	p.E34K	uc001fvj.1_5'Flank|PEA15_uc001fvl.2_Missense_Mutation_p.E55K|PEA15_uc001fvm.2_Missense_Mutation_p.E34K	NM_003768	NP_003759	Q15121	PEA15_HUMAN	phosphoprotein enriched in astrocytes 15	34	DED.				anti-apoptosis|apoptosis|carbohydrate transport|negative regulation of glucose import	cytoplasm|microtubule associated complex	protein binding				0	all_cancers(52;3.11e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CATCCCCAGCGAAAAGAGTGA	0.557		NA											12	75					0	0	0	0
KLHL20	27252	broad.mit.edu	37	1	173744918	173744918	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:173744918G>C	uc001gjc.2	+	10	1754	c.1575G>C	c.(1573-1575)GAG>GAC	p.E525D	KLHL20_uc010pmr.1_Missense_Mutation_p.E336D|KLHL20_uc009wwf.2_Missense_Mutation_p.E507D	NM_014458	NP_055273	Q9Y2M5	KLH20_HUMAN	kelch-like 20	525	Kelch 5.				cytoskeleton organization|negative regulation of apoptosis|proteasomal ubiquitin-dependent protein catabolic process|response to interferon-alpha	actin cytoskeleton|cell surface|Cul3-RING ubiquitin ligase complex|Golgi apparatus|perinuclear region of cytoplasm|PML body	actin binding|interferon-gamma binding|ubiquitin-protein ligase activity			ovary(1)	1						GCAGTGCTGAGAGATACAACC	0.453		NA											5	75					0	0	0	0
TNN	63923	broad.mit.edu	37	1	175097823	175097823	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:175097823G>A	uc001gkl.1	+	15	3384	c.3271G>A	c.(3271-3273)GAT>AAT	p.D1091N		NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	1091	Fibrinogen C-terminal.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		CCTGCATGGCGATGCCAGCCG	0.602		NA											10	82					0	0	0	0
PAPPA2	60676	broad.mit.edu	37	1	176740227	176740227	+	Silent	SNP	C	C	T			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:176740227C>T	uc001gkz.2	+	17	5790	c.4626C>T	c.(4624-4626)CTC>CTT	p.L1542L	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1542	Sushi 3.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						CTCACTGCCTCCAGGACAACC	0.488		NA											7	61					0	0	0	0
LAMC1	3915	broad.mit.edu	37	1	183103932	183103932	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:183103932G>C	uc001gpy.3	+	23	4244	c.3987G>C	c.(3985-3987)AAG>AAC	p.K1329N		NM_002293	NP_002284	P11047	LAMC1_HUMAN	laminin, gamma 1 precursor	1329	Potential.|Domain II and I.				axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent			ovary(3)|large_intestine(1)|kidney(1)	5					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGAAAGGCAAGACTGAACAGC	0.428		NA											32	174					0	0	0	0
LAMC1	3915	broad.mit.edu	37	1	183106903	183106903	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:183106903G>C	uc001gpy.3	+	26	4671	c.4414G>C	c.(4414-4416)GAA>CAA	p.E1472Q		NM_002293	NP_002284	P11047	LAMC1_HUMAN	laminin, gamma 1 precursor	1472	Potential.|Domain II and I.				axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent			ovary(3)|large_intestine(1)|kidney(1)	5					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GCAGGAAGCAGAAAAAGAGCT	0.428		NA											6	32					0	0	0	0
PRG4	10216	broad.mit.edu	37	1	186276564	186276565	+	Missense_Mutation	DNP	CA	CA	TG			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:186276564_186276565CA>TG	uc001gru.3	+	7	1764_1765	c.1713_1714CA>TG	c.(1711-1716)ACCACC>ACTGCC	p.T572A	PRG4_uc001grt.3_Missense_Mutation_p.T531A|PRG4_uc009wyl.2_Missense_Mutation_p.T479A|PRG4_uc009wym.2_Missense_Mutation_p.T438A|PRG4_uc010poo.1_Intron	NM_005807	NP_005798	Q92954	PRG4_HUMAN	proteoglycan 4 isoform A	572	59 X 8 AA repeats of K-X-P-X-P-T-T-X.|29.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						CTGCACCCACCACCCCCAAGAA	0.644		NA											4	106					0	0	0	0
PRG4	10216	broad.mit.edu	37	1	186277112	186277112	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:186277112C>G	uc001gru.3	+	7	2312	c.2261C>G	c.(2260-2262)CCT>CGT	p.P754R	PRG4_uc001grt.3_Missense_Mutation_p.P713R|PRG4_uc009wyl.2_Missense_Mutation_p.P661R|PRG4_uc009wym.2_Missense_Mutation_p.P620R|PRG4_uc010poo.1_Intron	NM_005807	NP_005798	Q92954	PRG4_HUMAN	proteoglycan 4 isoform A	754	59 X 8 AA repeats of K-X-P-X-P-T-T-X.|47; approximate.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						CCAACTACCCCTAAGGGGACT	0.602		NA											40	172					0	0	0	0
C1orf106	55765	broad.mit.edu	37	1	200880920	200880920	+	Silent	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:200880920G>A	uc001gvo.2	+	9	1584	c.1554G>A	c.(1552-1554)CCG>CCA	p.P518P	C1orf106_uc010ppm.1_Silent_p.P433P	NM_018265	NP_060735	Q3KP66	CA106_HUMAN	hypothetical protein LOC55765 isoform 1	518										skin(2)|ovary(1)	3						GCTATTTCCCGGCGGGGCGGT	0.726		NA											13	48					0	0	0	0
CDC42BPA	8476	broad.mit.edu	37	1	227268658	227268658	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:227268658C>A	uc001hqr.2	-	17	3359	c.2416G>T	c.(2416-2418)GAT>TAT	p.D806Y	CDC42BPA_uc001hqq.2_Missense_Mutation_p.D70Y|CDC42BPA_uc001hqs.2_Missense_Mutation_p.D725Y|CDC42BPA_uc009xes.2_Missense_Mutation_p.D806Y|CDC42BPA_uc010pvs.1_Missense_Mutation_p.D806Y|CDC42BPA_uc001hqp.2_5'UTR|CDC42BPA_uc001hqu.1_5'UTR	NM_003607	NP_003598	Q5VT25	MRCKA_HUMAN	CDC42-binding protein kinase alpha isoform B	806	Potential.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(6)|breast(2)|stomach(1)|ovary(1)|pancreas(1)	11		all_cancers(173;0.156)|Prostate(94;0.0792)				TCTGCTAGATCTTTAACCTCT	0.358		NA											18	64					2e-07	2.19e-07	1	0
CUBN	8029	broad.mit.edu	37	10	17164832	17164832	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr10:17164832C>G	uc001ioo.2	-	6	607	c.555G>C	c.(553-555)CAG>CAC	p.Q185H		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	185	EGF-like 2; calcium-binding (Potential).				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TGCCTCCATTCTGGCAGCTCA	0.383		NA											12	45					0	0	0	0
KIAA1462	57608	broad.mit.edu	37	10	30317105	30317105	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr10:30317105C>G	uc001iux.2	-	2	2031	c.1972G>C	c.(1972-1974)GAC>CAC	p.D658H	KIAA1462_uc001iuy.2_Intron|KIAA1462_uc001iuz.2_Missense_Mutation_p.D520H|KIAA1462_uc009xle.1_Missense_Mutation_p.D658H	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	658										ovary(4)	4						GTTTGTCTGTCTTCTTCTGGT	0.517		NA											8	51					0	0	0	0
GRID1	2894	broad.mit.edu	37	10	87487785	87487785	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr10:87487785C>G	uc001kdl.1	-	10	1461	c.1360G>C	c.(1360-1362)GAG>CAG	p.E454Q	GRID1_uc009xsu.1_RNA|GRID1_uc010qmf.1_Missense_Mutation_p.E25Q	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	454	Extracellular (Potential).					cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)	AGGATGTTCTCAGCCACCATC	0.448		NA								Multiple Myeloma(13;0.14)			17	156					0	0	0	0
FAM35A	54537	broad.mit.edu	37	10	88946848	88946848	+	Silent	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr10:88946848G>A	uc001kei.3	+	8	2313	c.2199G>A	c.(2197-2199)GCG>GCA	p.A733A	FAM35A_uc001kej.3_Silent_p.A179A	NM_019054	NP_061927	Q86V20	FA35A_HUMAN	hypothetical protein LOC54537	733										ovary(2)|skin(2)	4						GTAGGCCAGCGTTAATGACTG	0.353		NA											4	44					0	0	0	0
SH3PXD2A	9644	broad.mit.edu	37	10	105362900	105362900	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr10:105362900G>C	uc001kxj.1	-	14	2131	c.1991C>G	c.(1990-1992)TCA>TGA	p.S664*	SH3PXD2A_uc010qqr.1_Intron|SH3PXD2A_uc010qqs.1_Nonsense_Mutation_p.S499*|SH3PXD2A_uc010qqt.1_Nonsense_Mutation_p.S541*|SH3PXD2A_uc009xxn.1_Nonsense_Mutation_p.S499*|SH3PXD2A_uc010qqu.1_Nonsense_Mutation_p.S607*	NM_014631	NP_055446	Q5TCZ1	SPD2A_HUMAN	SH3 multiple domains 1	692	Ser-rich.				cell communication|superoxide metabolic process	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol binding|protein binding				0		Colorectal(252;0.0815)|Breast(234;0.131)		Epithelial(162;4.09e-10)|all cancers(201;2.73e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0119)		GGTGATGGATGAGGAAAAGGA	0.458		NA											26	144					0	0	0	0
COL17A1	1308	broad.mit.edu	37	10	105814753	105814753	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr10:105814753C>G	uc001kxr.2	-	20	1899	c.1730G>C	c.(1729-1731)AGT>ACT	p.S577T	COL17A1_uc010qqv.1_Missense_Mutation_p.S561T	NM_000494	NP_000485	Q9UMD9	COHA1_HUMAN	alpha 1 type XVII collagen	577	Extracellular (Potential).|Triple-helical region.				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		AGGGCCTGGACTTCCCATGTC	0.383		NA											3	26					0	0	0	0
BTBD16	118663	broad.mit.edu	37	10	124097537	124097537	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr10:124097537G>C	uc001lgc.1	+	16	1709	c.1458G>C	c.(1456-1458)TTG>TTC	p.L486F	BTBD16_uc001lgd.1_Missense_Mutation_p.L485F	NM_144587	NP_653188	Q32M84	BTBDG_HUMAN	BTB (POZ) domain containing 16	486										skin(1)	1		all_neural(114;0.107)|Lung NSC(174;0.175)|all_lung(145;0.222)|Breast(234;0.238)				TTTAGACCTTGAAAATCCAAA	0.403		NA											6	38					0	0	0	0
DUSP8	1850	broad.mit.edu	37	11	1579116	1579116	+	Silent	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr11:1579116G>A	uc001lts.2	-	6	857	c.729C>T	c.(727-729)ATC>ATT	p.I243I		NM_004420	NP_004411	Q13202	DUS8_HUMAN	dual specificity phosphatase 8	243	Tyrosine-protein phosphatase.				inactivation of MAPK activity	cytoplasm|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0		all_epithelial(84;0.000134)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000621)|Lung(200;0.0687)|LUSC - Lung squamous cell carcinoma(625;0.0825)		GACAGTGGACGATGACTTGGC	0.617		NA											13	60					0	0	0	0
TRIM68	55128	broad.mit.edu	37	11	4622349	4622349	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr11:4622349G>C	uc001lzf.1	-	6	1053	c.815C>G	c.(814-816)TCT>TGT	p.S272C	TRIM68_uc001lzg.1_Missense_Mutation_p.S49C|TRIM68_uc010qyj.1_Intron	NM_018073	NP_060543	Q6AZZ1	TRI68_HUMAN	ring finger protein 137	272					protein autoubiquitination|regulation of androgen receptor signaling pathway	Golgi apparatus|nucleolus|perinuclear region of cytoplasm	androgen receptor binding|histone acetyltransferase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;9.49e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0288)|LUSC - Lung squamous cell carcinoma(625;0.192)		CAAGCTCCAAGATTTGCTCCT	0.547		NA											12	95					0	0	0	0
OR52E2	119678	broad.mit.edu	37	11	5080352	5080352	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr11:5080352G>A	uc010qyw.1	-	1	506	c.506C>T	c.(505-507)CCC>CTC	p.P169L		NM_001005164	NP_001005164	Q8NGJ4	O52E2_HUMAN	olfactory receptor, family 52, subfamily E,	169	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.03e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.191)		CCCACAGAAGGGCAACCGCAA	0.418		NA											3	24					0	0	0	0
OR56A1	120796	broad.mit.edu	37	11	6048851	6048851	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr11:6048851C>G	uc010qzw.1	-	1	84	c.84G>C	c.(82-84)CAG>CAC	p.Q28H		NM_001001917	NP_001001917	Q8NGH5	O56A1_HUMAN	olfactory receptor, family 56, subfamily A,	28	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|breast(1)	3		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCTGCCAACTCTGGAAGTTGG	0.577		NA											7	111					0	0	0	0
ANO5	203859	broad.mit.edu	37	11	22301307	22301307	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr11:22301307T>C	uc001mqi.2	+	22	3055	c.2738T>C	c.(2737-2739)CTC>CCC	p.L913P	ANO5_uc001mqj.2_Missense_Mutation_p.L912P	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	anoctamin 5 isoform a	913	Cytoplasmic (Potential).					chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4						AAATCAACACTCTAATCAGTA	0.408		NA											5	22					0	0	0	0
TTC17	55761	broad.mit.edu	37	11	43436245	43436245	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr11:43436245G>C	uc001mxi.2	+	16	2184	c.2170G>C	c.(2170-2172)GAG>CAG	p.E724Q	TTC17_uc001mxh.2_Missense_Mutation_p.E724Q|TTC17_uc010rfj.1_Missense_Mutation_p.E667Q|TTC17_uc001mxj.2_Missense_Mutation_p.E494Q	NM_018259	NP_060729	Q96AE7	TTC17_HUMAN	tetratricopeptide repeat domain 17	724							binding			ovary(5)	5						CAAATGTCCAGAGTGTGAAAA	0.438		NA											9	91					0	0	0	0
PYGM	5837	broad.mit.edu	37	11	64521767	64521767	+	Silent	SNP	C	C	G			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr11:64521767C>G	uc001oax.3	-	9	1867	c.1050G>C	c.(1048-1050)CTG>CTC	p.L350L	PYGM_uc001oay.3_Silent_p.L262L	NM_005609	NP_005600	P11217	PYGM_HUMAN	muscle glycogen phosphorylase isoform 1	350					glucose metabolic process|glycogen catabolic process	cytosol	glycogen phosphorylase activity|protein binding			ovary(2)	2					Pyridoxal Phosphate(DB00114)	GGATCCTCATCAGCTCGGGGA	0.632		NA											5	66					0	0	0	0
SF3B2	10992	broad.mit.edu	37	11	65829169	65829169	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr11:65829169G>A	uc001ogy.1	+	15	1832	c.1792G>A	c.(1792-1794)GAG>AAG	p.E598K		NM_006842	NP_006833	Q13435	SF3B2_HUMAN	splicing factor 3B subunit 2	598					interspecies interaction between organisms	catalytic step 2 spliceosome|nucleoplasm|U12-type spliceosomal complex	nucleic acid binding|protein binding			ovary(2)|breast(1)	3						GAAGGAGTTCGAGACACGACT	0.498		NA											8	35					0	0	0	0
DPP3	10072	broad.mit.edu	37	11	66272236	66272236	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr11:66272236C>T	uc001oig.1	+	17	2094	c.2032C>T	c.(2032-2034)CGC>TGC	p.R678C	DPP3_uc001oif.1_Missense_Mutation_p.R678C|DPP3_uc010rpe.1_Missense_Mutation_p.R667C|DPP3_uc001oih.1_Silent_p.L45L	NM_005700	NP_005691	Q9NY33	DPP3_HUMAN	dipeptidyl peptidase III	678					proteolysis	cytoplasm	aminopeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity			ovary(1)|skin(1)	2						GCCCAACACTCGCCTTGAAGG	0.567		NA											19	101					0	0	0	0
CTSF	8722	broad.mit.edu	37	11	66335085	66335085	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr11:66335085G>A	uc001oip.2	-	3	451	c.361C>T	c.(361-363)CGG>TGG	p.R121W		NM_003793	NP_003784	Q9UBX1	CATF_HUMAN	cathepsin F precursor	121					proteolysis	lysosome	cysteine-type endopeptidase activity				0						CAGTCCTTCCGCAGCAGCACG	0.592		NA											12	135					0	0	0	0
APOA5	116519	broad.mit.edu	37	11	116662530	116662530	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr11:116662530G>A	uc001ppr.2	-	1	55	c.47C>T	c.(46-48)TCA>TTA	p.S16L	APOA5_uc009yze.2_Missense_Mutation_p.S16L|APOA5_uc009yzf.2_Missense_Mutation_p.S16L|APOA5_uc009yzg.2_Intron	NM_052968	NP_443200	Q6Q788	APOA5_HUMAN	apolipoprotein AV precursor	16					acylglycerol homeostasis|cholesterol homeostasis|lipid transport|lipoprotein metabolic process|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of receptor-mediated endocytosis|positive regulation of triglyceride catabolic process|positive regulation of very-low-density lipoprotein particle remodeling|tissue regeneration|triglyceride catabolic process|triglyceride homeostasis	chylomicron|high-density lipoprotein particle|very-low-density lipoprotein particle	enzyme binding|heparin binding|lipoprotein lipase activator activity|low-density lipoprotein particle receptor binding|phosphatidylcholine binding				0	all_hematologic(175;0.0487)	all_cancers(61;3.31e-09)|all_epithelial(67;8.03e-06)|Breast(348;0.0126)|Melanoma(852;0.0153)|Acute lymphoblastic leukemia(157;0.0257)|Medulloblastoma(222;0.0425)|all_hematologic(158;0.0433)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;4.93e-06)|all cancers(92;0.000123)|OV - Ovarian serous cystadenocarcinoma(223;0.149)		AGACCCACCTGAAAGAAGAGC	0.632		NA									OREG0021366|OREG0003485	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)|type=REGULATORY REGION|Gene=APOA5|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	4	30					0	0	0	0
ABCG4	64137	broad.mit.edu	37	11	119025544	119025544	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr11:119025544C>G	uc001pvs.2	+	6	941	c.605C>G	c.(604-606)TCT>TGT	p.S202C	ABCG4_uc009zar.2_Missense_Mutation_p.S202C	NM_022169	NP_071452	Q9H172	ABCG4_HUMAN	ATP-binding cassette, subfamily G, member 4	202	Cytoplasmic (Potential).|ABC transporter.				cholesterol efflux	integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)	2	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		GCCCTGCTCTCTGGCGGGCAG	0.622		NA											17	142					0	0	0	0
OR8B4	283162	broad.mit.edu	37	11	124294739	124294739	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr11:124294739G>A	uc010sak.1	-	1	29	c.29C>T	c.(28-30)ACT>ATT	p.T10I		NM_001005196	NP_001005196	Q96RC9	OR8B4_HUMAN	olfactory receptor, family 8, subfamily B,	10	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		GATAAACTCAGTCACTGAGGA	0.488		NA											6	45					0	0	0	0
C12orf5	57103	broad.mit.edu	37	12	4459054	4459054	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr12:4459054C>T	uc001qmp.2	+	4	341	c.262C>T	c.(262-264)CGG>TGG	p.R88W		NM_020375	NP_065108	Q9NQ88	TIGAR_HUMAN	TP53-induced glycolysis and apoptosis regulator	88						intracellular	fructose-2,6-bisphosphate 2-phosphatase activity			skin(1)	1			all cancers(3;1.15e-07)|Colorectal(7;0.00165)|OV - Ovarian serous cystadenocarcinoma(31;0.00596)|COAD - Colon adenocarcinoma(12;0.0229)|GBM - Glioblastoma multiforme(3;0.0266)|STAD - Stomach adenocarcinoma(119;0.206)			CTCAAGACTTCGGGAAAGGGT	0.353		NA											8	27					0	0	0	0
PCBP2	5094	broad.mit.edu	37	12	53849783	53849783	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr12:53849783G>T	uc001sdl.3	+	5	591	c.241G>T	c.(241-243)GAG>TAG	p.E81*	PCBP2_uc001sdc.3_Nonsense_Mutation_p.E81*|PCBP2_uc001sdb.3_Nonsense_Mutation_p.E81*|PCBP2_uc001sde.3_Nonsense_Mutation_p.E81*|PCBP2_uc001sdi.3_Nonsense_Mutation_p.E81*|PCBP2_uc001sdd.3_Nonsense_Mutation_p.E81*|PCBP2_uc001sdf.3_Nonsense_Mutation_p.E81*|PCBP2_uc009zna.2_Intron|PCBP2_uc010soh.1_Nonsense_Mutation_p.E81*|PCBP2_uc009zmz.1_Intron	NM_001128911	NP_001122383	Q15366	PCBP2_HUMAN	poly(rC) binding protein 2 isoform d	81					innate immune response|negative regulation of defense response to virus|negative regulation of type I interferon production|nuclear mRNA splicing, via spliceosome|proteasomal ubiquitin-dependent protein catabolic process|response to virus	cytosol|nucleoplasm|ribonucleoprotein complex	DNA binding|RNA binding|ubiquitin protein ligase binding				0						CAAACTGGAAGAGGTTTGTTG	0.413		NA											15	189					2.35e-11	2.61e-11	1	0
GRIP1	23426	broad.mit.edu	37	12	66786483	66786483	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr12:66786483G>T	uc001stk.2	-	17	2328	c.2087C>A	c.(2086-2088)ACC>AAC	p.T696N	GRIP1_uc010sta.1_Missense_Mutation_p.T640N|GRIP1_uc001stj.2_Missense_Mutation_p.T478N|GRIP1_uc001stl.1_Missense_Mutation_p.T588N|GRIP1_uc001stm.2_Missense_Mutation_p.T696N	NM_021150	NP_066973	Q9Y3R0	GRIP1_HUMAN	glutamate receptor interacting protein 1	748	PDZ 6.				androgen receptor signaling pathway|intracellular signal transduction|positive regulation of transcription, DNA-dependent|synaptic transmission	cell junction|cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|postsynaptic membrane	androgen receptor binding|beta-catenin binding|protein C-terminus binding|receptor signaling complex scaffold activity|transcription coactivator activity			ovary(2)	2			GBM - Glioblastoma multiforme(2;0.00069)	GBM - Glioblastoma multiforme(28;0.0933)		AATTTTCAAGGTGACAGTCTC	0.428		NA											10	94					0.000442599	0.000474089	1	0
PTPRB	5787	broad.mit.edu	37	12	70931979	70931979	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr12:70931979C>G	uc001swb.3	-	26	5278	c.5248G>C	c.(5248-5250)GAT>CAT	p.D1750H	uc001svz.2_RNA|PTPRB_uc010sto.1_Missense_Mutation_p.D1660H|PTPRB_uc010stp.1_Missense_Mutation_p.D1660H|PTPRB_uc001swc.3_Missense_Mutation_p.D1968H|PTPRB_uc001swa.3_Missense_Mutation_p.D1880H	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1750	Cytoplasmic (Potential).|Tyrosine-protein phosphatase.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			GGATCATCATCTACATTGGAG	0.428		NA											10	58					0	0	0	0
PMCH	5367	broad.mit.edu	37	12	102591364	102591364	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr12:102591364G>T	uc001tjl.2	-	1	251	c.185C>A	c.(184-186)TCC>TAC	p.S62Y		NM_002674	NP_002665	P20382	MCH_HUMAN	pro-melanin-concentrating hormone	62					cell differentiation|neuropeptide signaling pathway|spermatogenesis|synaptic transmission		melanin-concentrating hormone activity				0						TTGTTCCAGGGAAGGAGCAAT	0.353		NA											10	39					0.00621372	0.0064766	1	0
APPL2	55198	broad.mit.edu	37	12	105568151	105568151	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr12:105568151G>A	uc001tlf.1	-	21	2154	c.1936C>T	c.(1936-1938)CAA>TAA	p.Q646*	APPL2_uc010swt.1_Nonsense_Mutation_p.Q603*|APPL2_uc001tlg.1_Nonsense_Mutation_p.Q400*|APPL2_uc010swu.1_Nonsense_Mutation_p.Q652*	NM_018171	NP_060641	Q8NEU8	DP13B_HUMAN	adaptor protein, phosphotyrosine interaction, PH	646					cell cycle|cell proliferation|signal transduction	early endosome membrane|nucleus	protein binding			upper_aerodigestive_tract(1)	1						TCATCTGGTTGATCGTTTAAC	0.453		NA											7	43					0	0	0	0
RIC8B	55188	broad.mit.edu	37	12	107245264	107245264	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr12:107245264G>A	uc001tlx.2	+	7	1323	c.1198G>A	c.(1198-1200)GAA>AAA	p.E400K	RIC8B_uc001tlw.2_Missense_Mutation_p.E400K|RIC8B_uc001tly.2_Missense_Mutation_p.E360K|RIC8B_uc001tlz.2_RNA|RIC8B_uc009zur.2_RNA	NM_018157	NP_060627	Q9NVN3	RIC8B_HUMAN	resistance to inhibitors of cholinesterase 8	400					regulation of G-protein coupled receptor protein signaling pathway	cell cortex|cytosol|plasma membrane	G-protein alpha-subunit binding|guanyl-nucleotide exchange factor activity			ovary(1)	1						AAATCGACCTGAAGTTGGCTC	0.448		NA											8	76					0	0	0	0
RIC8B	55188	broad.mit.edu	37	12	107245315	107245315	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr12:107245315G>A	uc001tlx.2	+	7	1374	c.1249G>A	c.(1249-1251)GAC>AAC	p.D417N	RIC8B_uc001tlw.2_Missense_Mutation_p.D417N|RIC8B_uc001tly.2_Missense_Mutation_p.D377N|RIC8B_uc001tlz.2_RNA|RIC8B_uc009zur.2_RNA	NM_018157	NP_060627	Q9NVN3	RIC8B_HUMAN	resistance to inhibitors of cholinesterase 8	417					regulation of G-protein coupled receptor protein signaling pathway	cell cortex|cytosol|plasma membrane	G-protein alpha-subunit binding|guanyl-nucleotide exchange factor activity			ovary(1)	1						GACACATGTTGACCTTGGAGT	0.448		NA											6	68					0	0	0	0
ATXN2	6311	broad.mit.edu	37	12	111956093	111956093	+	Silent	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr12:111956093G>A	uc001tsj.2	-	9	1767	c.1605C>T	c.(1603-1605)TTC>TTT	p.F535F	ATXN2_uc001tsh.2_Silent_p.F270F|ATXN2_uc001tsi.2_Silent_p.F246F|ATXN2_uc001tsk.2_RNA|ATXN2_uc001tsm.1_Silent_p.F270F	NM_002973	NP_002964	Q99700	ATX2_HUMAN	ataxin 2	535					cell death|cytoplasmic mRNA processing body assembly|regulation of translation|RNA metabolic process|RNA transport|stress granule assembly	nucleus|perinuclear region of cytoplasm|polysome|stress granule|trans-Golgi network	protein C-terminus binding|RNA binding			ovary(1)|breast(1)	2						AATTCGGGTTGAAATCTGAAG	0.423		NA											15	73					0	0	0	0
MED13L	23389	broad.mit.edu	37	12	116429339	116429339	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr12:116429339G>C	uc001tvw.2	-	17	3475	c.3420C>G	c.(3418-3420)ATC>ATG	p.I1140M		NM_015335	NP_056150	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	1140					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					skin(4)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	8	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		CCGCCCCTTTGATGTTCATGT	0.473		NA											16	70					0	0	0	0
AKAP11	11215	broad.mit.edu	37	13	42873613	42873613	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr13:42873613C>T	uc001uys.1	+	8	906	c.731C>T	c.(730-732)TCA>TTA	p.S244L		NM_016248	NP_057332	Q9UKA4	AKA11_HUMAN	A-kinase anchor protein 11	244	Ser-rich.				intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			ovary(1)|central_nervous_system(1)	2		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		CAGCAGAAGTCATTGGCTAAA	0.443		NA											15	56					0	0	0	0
PCDH17	27253	broad.mit.edu	37	13	58208221	58208221	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr13:58208221C>T	uc001vhq.1	+	1	2433	c.1541C>T	c.(1540-1542)TCG>TTG	p.S514L	PCDH17_uc010aec.1_Missense_Mutation_p.S514L	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	514	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		ATCCTGCCCTCGCACATCGGC	0.592		NA											8	39					0	0	0	0
RNF219	79596	broad.mit.edu	37	13	79209281	79209281	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr13:79209281C>T	uc001vkw.1	-	5	661	c.602G>A	c.(601-603)CGA>CAA	p.R201Q	RNF219_uc010afb.1_5'UTR|RNF219_uc010afc.2_Intron	NM_024546	NP_078822	Q5W0B1	RN219_HUMAN	ring finger protein 219	201	Potential.						zinc ion binding			large_intestine(2)	2		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.0848)		GBM - Glioblastoma multiforme(99;0.0414)		AGCCTTCAGTCGTAAATTCTC	0.343		NA											7	50					0	0	0	0
GPC6	10082	broad.mit.edu	37	13	94938726	94938726	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr13:94938726C>A	uc001vlt.2	+	5	1633	c.1001C>A	c.(1000-1002)TCT>TAT	p.S334Y	GPC6_uc010tig.1_Missense_Mutation_p.S334Y	NM_005708	NP_005699	Q9Y625	GPC6_HUMAN	glypican 6 precursor	334						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding				0	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;5.48e-07)|all_epithelial(2;5.69e-08)|all_lung(2;2.19e-05)|Lung NSC(4;6.09e-05)|Breast(118;0.0395)|Renal(2;0.0568)|Hepatocellular(115;0.217)				ATGCAGGTGTCTGCAAAGGTA	0.418		NA											5	41					0.00116845	0.0012321	1	0
CDH24	64403	broad.mit.edu	37	14	23523465	23523465	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr14:23523465G>A	uc001wil.2	-	6	1117	c.857C>T	c.(856-858)CCA>CTA	p.P286L	CDH24_uc010akf.2_Missense_Mutation_p.P286L|CDH24_uc001win.3_Missense_Mutation_p.P286L	NM_022478	NP_071923	Q86UP0	CAD24_HUMAN	cadherin-like 24 isoform 1	286	Extracellular (Potential).|Cadherin 3.				adherens junction organization|cell junction assembly|cell-cell adhesion|homophilic cell adhesion	cell-cell junction|cell-cell junction|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|delta-catenin binding			central_nervous_system(1)	1	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.00654)		CCCCAGGTCTGGGTCCTGGGC	0.637		NA											35	164					0	0	0	0
MYH7	4625	broad.mit.edu	37	14	23897712	23897712	+	Silent	SNP	C	C	T			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr14:23897712C>T	uc001wjx.2	-	15	1681	c.1575G>A	c.(1573-1575)GAG>GAA	p.E525E		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	525	Myosin head-like.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		GAGGCACCTTCTCGATGAGGT	0.502		NA											7	50					0	0	0	0
FAM179B	23116	broad.mit.edu	37	14	45432505	45432505	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr14:45432505C>G	uc001wvv.2	+	1	1090	c.881C>G	c.(880-882)TCT>TGT	p.S294C	FAM179B_uc001wvw.2_Missense_Mutation_p.S294C|FAM179B_uc010anc.2_RNA|KLHL28_uc001wvq.2_5'Flank|KLHL28_uc001wvr.2_5'Flank|FAM179B_uc010anb.1_Missense_Mutation_p.S294C|FAM179B_uc001wvu.2_Missense_Mutation_p.S294C	NM_015091	NP_055906	Q9Y4F4	F179B_HUMAN	hypothetical protein LOC23116	294							binding			skin(2)|upper_aerodigestive_tract(1)	3						AGGTTTCAATCTTACATTTCT	0.498		NA											20	89					0	0	0	0
PPM1A	5494	broad.mit.edu	37	14	60750214	60750214	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr14:60750214G>C	uc010apn.2	+	3	1195	c.793G>C	c.(793-795)GAG>CAG	p.E265Q	PPM1A_uc001xew.3_Missense_Mutation_p.E338Q|PPM1A_uc001xex.3_Missense_Mutation_p.E265Q|PPM1A_uc001xey.3_Missense_Mutation_p.E265Q	NM_021003	NP_066283	P35813	PPM1A_HUMAN	protein phosphatase 1A isoform 1	265					cell cycle arrest|insulin receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway|protein dephosphorylation|Wnt receptor signaling pathway	cytosol|nucleus|protein serine/threonine phosphatase complex	magnesium ion binding|manganese ion binding|protein serine/threonine phosphatase activity|signal transducer activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.046)		TGATGACCTTGAGAAAGTTTG	0.348		NA											8	86					0	0	0	0
ESRRB	2103	broad.mit.edu	37	14	76966231	76966231	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr14:76966231C>G	uc001xsr.2	+	10	1693	c.1322C>G	c.(1321-1323)TCT>TGT	p.S441C	ESRRB_uc001xso.2_RNA	NM_004452	NP_004443	A2VDJ2	A2VDJ2_HUMAN	estrogen-related receptor beta	441						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.0213)		CTTAGAGGATCTCCCAAGGAT	0.512		NA											6	53					0	0	0	0
ASB2	51676	broad.mit.edu	37	14	94417555	94417555	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr14:94417555G>C	uc001ycc.1	-	4	1015	c.526C>G	c.(526-528)CTG>GTG	p.L176V	ASB2_uc001ycd.2_Missense_Mutation_p.L224V|ASB2_uc001yce.1_Missense_Mutation_p.L122V	NM_016150	NP_057234	Q96Q27	ASB2_HUMAN	ankyrin repeat and SOCS box-containing protein	176	ANK 4.				intracellular signal transduction					ovary(1)|pancreas(1)	2		all_cancers(154;0.13)		COAD - Colon adenocarcinoma(157;0.217)|Epithelial(152;0.232)		TGCTGCACCAGAATCTTCACG	0.617		NA											5	57					0	0	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102476268	102476268	+	Silent	SNP	C	C	T			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr14:102476268C>T	uc001yks.2	+	30	6230	c.6066C>T	c.(6064-6066)TAC>TAT	p.Y2022Y		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	2022	AAA 1 (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						ACCCTGGCTACGCGGGCCGGT	0.552		NA											7	38					0	0	0	0
HSP90AA1	3320	broad.mit.edu	37	14	102552205	102552205	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr14:102552205G>A	uc001yku.3	-	3	609	c.419C>T	c.(418-420)TCT>TTT	p.S140F	HSP90AA1_uc001ykv.3_Missense_Mutation_p.S262F|HSP90AA1_uc001ykw.1_Intron|HSP90AA1_uc001ykx.1_Missense_Mutation_p.S129F	NM_005348	NP_005339	P07900	HS90A_HUMAN	heat shock 90kDa protein 1, alpha isoform 2	140					axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding			ovary(2)|central_nervous_system(2)|prostate(1)|lung(1)|breast(1)	7					Rifabutin(DB00615)	CAAATAAGCAGAATAAAAACC	0.473		NA											16	52					0	0	0	0
NIPA2	81614	broad.mit.edu	37	15	23012399	23012399	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr15:23012399G>A	uc001yux.2	-	7	941	c.328C>T	c.(328-330)CTT>TTT	p.L110F	NIPA2_uc001yuy.2_Missense_Mutation_p.L110F|NIPA2_uc001yuz.2_Missense_Mutation_p.L110F|NIPA2_uc001yva.2_Missense_Mutation_p.L91F|NIPA2_uc001yvb.2_Missense_Mutation_p.L110F|NIPA2_uc010ayb.2_Missense_Mutation_p.L91F	NM_030922	NP_112184	Q8N8Q9	NIPA2_HUMAN	non imprinted in Prader-Willi/Angelman syndrome	110	Helical; (Potential).					early endosome|integral to membrane|plasma membrane				haematopoietic_and_lymphoid_tissue(1)	1		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;1.48e-06)|Epithelial(43;1.44e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000353)		TTCCCATGAAGATTAAGTCTT	0.333		NA											9	67					0	0	0	0
RYR3	6263	broad.mit.edu	37	15	34131070	34131070	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr15:34131070G>A	uc001zhi.2	+	89	12959	c.12889G>A	c.(12889-12891)GAA>AAA	p.E4297K	RYR3_uc010bar.2_Missense_Mutation_p.E4292K	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	4297					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GCATGGGCCTGAAGTGGGTTT	0.458		NA											7	34					0	0	0	0
SEMA6D	80031	broad.mit.edu	37	15	48056145	48056145	+	Silent	SNP	G	G	C			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr15:48056145G>C	uc010bek.2	+	10	1206	c.846G>C	c.(844-846)CTG>CTC	p.L282L	SEMA6D_uc001zvw.2_Silent_p.L282L|SEMA6D_uc001zvx.1_Silent_p.L282L|SEMA6D_uc001zvy.2_Silent_p.L282L|SEMA6D_uc001zvz.2_Silent_p.L282L|SEMA6D_uc001zwa.2_Silent_p.L282L|SEMA6D_uc001zwb.2_Silent_p.L282L|SEMA6D_uc001zwc.2_Silent_p.L282L	NM_153618	NP_705871	Q8NFY4	SEM6D_HUMAN	semaphorin 6D isoform 4 precursor	282	Sema.|Extracellular (Potential).				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			skin(3)|breast(1)	4		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		AGGCTCGGCTGAACTGTTCTG	0.488		NA											11	86					0	0	0	0
C15orf42	90381	broad.mit.edu	37	15	90167507	90167507	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr15:90167507G>C	uc002boe.2	+	20	3966	c.3966G>C	c.(3964-3966)AAG>AAC	p.K1322N	C15orf42_uc010upv.1_RNA	NM_152259	NP_689472	Q7Z2Z1	TICRR_HUMAN	leucine-rich repeat kinase 1	1322	Pro-rich.				cell cycle|DNA repair|DNA replication|formation of translation preinitiation complex|G2/M transition checkpoint|mitotic cell cycle DNA replication checkpoint|regulation of DNA-dependent DNA replication initiation|response to ionizing radiation	nucleus	chromatin binding|protein binding			ovary(4)|central_nervous_system(2)|skin(1)	7	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			TCTCCAAGAAGAGTCCATTTA	0.463		NA											10	128					0	0	0	0
HS3ST6	64711	broad.mit.edu	37	16	1962054	1962054	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr16:1962054G>A	uc002cnf.2	-	2	473	c.473C>T	c.(472-474)TCC>TTC	p.S158F		NM_001009606	NP_001009606	C9JH64	C9JH64_HUMAN	heparan sulfate (glucosamine)	158											0						GGCGTAGTCGGAGATGGCCCG	0.716		NA											5	31					0	0	0	0
KIAA0556	23247	broad.mit.edu	37	16	27751533	27751533	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr16:27751533G>C	uc002dow.2	+	15	1939	c.1915G>C	c.(1915-1917)GAA>CAA	p.E639Q		NM_015202	NP_056017	O60303	K0556_HUMAN	hypothetical protein LOC23247	639	Potential.									ovary(4)|large_intestine(2)|upper_aerodigestive_tract(1)|skin(1)	8						TCACTCGGAAGAAAGCAAAGG	0.562		NA											7	59					0	0	0	0
SRCAP	10847	broad.mit.edu	37	16	30749246	30749246	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr16:30749246G>A	uc002dze.1	+	34	8270	c.7885G>A	c.(7885-7887)GAG>AAG	p.E2629K	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Missense_Mutation_p.E2424K	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	2629	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			AGATTCTGCTGAGGGGACCAC	0.582		NA											16	80					0	0	0	0
ZNF423	23090	broad.mit.edu	37	16	49672763	49672763	+	Silent	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr16:49672763G>A	uc002efs.2	-	5	598	c.300C>T	c.(298-300)CTC>CTT	p.L100L	ZNF423_uc010vgn.1_5'UTR	NM_015069	NP_055884	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	100					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(1)|lung(1)|kidney(1)|pancreas(1)	4		all_cancers(37;0.0155)				CCACCCAGGAGAGTTGTGGGT	0.587		NA											6	45					0	0	0	0
TK2	7084	broad.mit.edu	37	16	66562953	66562953	+	Silent	SNP	C	C	T			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr16:66562953C>T	uc002eos.2	-	6	744	c.519G>A	c.(517-519)TTG>TTA	p.L173L	TK2_uc010vip.1_Silent_p.L34L|TK2_uc002eor.2_Silent_p.L100L|TK2_uc010cdq.2_Silent_p.L100L|TK2_uc010cdr.2_Silent_p.L82L|TK2_uc010viq.1_Silent_p.L155L|TK2_uc010vir.1_Silent_p.L148L	NM_004614	NP_004605	O00142	KITM_HUMAN	thymidine kinase 2, mitochondrial	131					pyrimidine base metabolic process|pyrimidine nucleoside salvage	mitochondrial matrix	ATP binding|phosphotransferase activity, alcohol group as acceptor|thymidine kinase activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0736)|Epithelial(162;0.237)		ACCTCTCCATCAACCGTACAG	0.393		NA											16	76					0	0	0	0
ZFHX3	463	broad.mit.edu	37	16	72984803	72984803	+	Silent	SNP	C	C	T			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr16:72984803C>T	uc002fck.2	-	3	3454	c.2781G>A	c.(2779-2781)CTG>CTA	p.L927L	ZFHX3_uc002fcl.2_Silent_p.L13L	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	927					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				CCAGGTTCATCAGCTCCTCTG	0.617		NA											10	58					0	0	0	0
ALOX15	246	broad.mit.edu	37	17	4535217	4535217	+	Silent	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr17:4535217G>A	uc002fyh.2	-	13	1790	c.1776C>T	c.(1774-1776)ATC>ATT	p.I592I	ALOX15_uc010vsd.1_Silent_p.I553I|ALOX15_uc010vse.1_Silent_p.I614I	NM_001140	NP_001131	P16050	LOX15_HUMAN	arachidonate 15-lipoxygenase	592	Lipoxygenase.				inflammatory response|leukotriene biosynthetic process	nucleus	arachidonate 15-lipoxygenase activity|iron ion binding|lipoxygenase activity			skin(3)|ovary(1)|lung(1)	5				READ - Rectum adenocarcinoma(115;0.0327)	Ciclopirox(DB01188)|Masoprocol(DB00179)|Zileuton(DB00744)	GCTGCCAAGTGATGGACATCT	0.627		NA											4	47					0	0	0	0
CCDC144A	9720	broad.mit.edu	37	17	16594003	16594003	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr17:16594003G>C	uc002gqk.1	+	1	365	c.289G>C	c.(289-291)GAG>CAG	p.E97Q		NM_014695	NP_055510	A2RUR9	C144A_HUMAN	coiled-coil domain containing 144A	97											0						CCCTGGGGTGGAGCACATCTT	0.647		NA											69	197					0	0	0	0
KRT13	3860	broad.mit.edu	37	17	39659616	39659616	+	Silent	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr17:39659616G>A	uc002hwu.1	-	3	721	c.658C>T	c.(658-660)CTG>TTG	p.L220L	KRT13_uc002hwv.1_Silent_p.L220L|KRT13_uc002hww.2_Silent_p.L113L|KRT13_uc010wfr.1_Silent_p.L113L|KRT13_uc010cxo.2_Silent_p.L220L|KRT13_uc002hwx.1_Silent_p.L208L	NM_153490	NP_705694	P13646	K1C13_HUMAN	keratin 13 isoform a	220	Coil 1B.|Rod.				epidermis development	intermediate filament	structural molecule activity			ovary(2)|skin(2)|pancreas(1)	5		Breast(137;0.000286)				GTCTTAGACAGAGTGAGCTCA	0.527		NA											20	111					0	0	0	0
WNT3	7473	broad.mit.edu	37	17	44895960	44895960	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr17:44895960C>G	uc002ikv.2	-	1	123	c.4G>C	c.(4-6)GAG>CAG	p.E2Q		NM_030753	NP_110380	P56703	WNT3_HUMAN	wingless-type MMTV integration site family,	2					canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|cellular response to retinoic acid|dorsal/ventral axis specification|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic pattern specification|head morphogenesis|hemopoietic stem cell proliferation|inner ear morphogenesis|limb bud formation|mammary gland epithelium development|mesoderm formation|midbrain-hindbrain boundary development|negative regulation of fat cell differentiation|positive regulation of cell proliferation|Spemann organizer formation at the anterior end of the primitive streak|Wnt receptor signaling pathway, calcium modulating pathway	early endosome|extracellular space|late endosome|membrane fraction|membrane raft|plasma membrane|proteinaceous extracellular matrix	frizzled binding|frizzled-2 binding|signal transducer activity			lung(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.0257)			AGGTGGGGCTCCATTAGAAGA	0.602		NA											2	9					0	0	0	0
CSHL1	1444	broad.mit.edu	37	17	61988231	61988231	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr17:61988231G>C	uc002jda.1	-	2	126	c.64C>G	c.(64-66)CAA>GAA	p.Q22E	CSHL1_uc002jcz.1_Missense_Mutation_p.Q22E|CSHL1_uc002jdb.1_Intron|CSHL1_uc002jdc.1_Intron|CSHL1_uc002jdd.1_Missense_Mutation_p.Q22E|CSHL1_uc002jde.2_Missense_Mutation_p.Q50E|CSHL1_uc002jdf.2_Intron|CSHL1_uc002jdg.2_Missense_Mutation_p.Q22E|CSHL1_uc002jdh.2_Intron	NM_022579	NP_072101	Q14406	CSHL_HUMAN	chorionic somatomammotropin hormone-like 1	22						extracellular region	hormone activity|metal ion binding				0						CCAGCCTCTTGAAGCCAGGGC	0.612		NA											5	57					0	0	0	0
COG1	9382	broad.mit.edu	37	17	71189326	71189326	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr17:71189326G>C	uc002jjg.2	+	1	154	c.118G>C	c.(118-120)GAG>CAG	p.E40Q	COG1_uc002jjh.2_Missense_Mutation_p.E40Q|COG1_uc002jjf.1_Missense_Mutation_p.E40Q	NM_018714	NP_061184	Q8WTW3	COG1_HUMAN	component of oligomeric golgi complex 1	40					Golgi organization|intra-Golgi vesicle-mediated transport|protein transport	Golgi membrane|Golgi transport complex	protein binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(166;0.197)			GGTTCGGGCCGAGATCGAGCA	0.687		NA											5	17					0	0	0	0
C17orf77	146723	broad.mit.edu	37	17	72588192	72588192	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr17:72588192G>A	uc002jla.1	+	3	369	c.7G>A	c.(7-9)GAA>AAA	p.E3K	CD300LD_uc002jkz.2_Intron	NM_152460	NP_689673	Q96MU5	CQ077_HUMAN	hypothetical protein LOC146723	3						extracellular region					0						ATGGATGGATGAATTGGCGCT	0.443		NA											19	139					0	0	0	0
HGS	9146	broad.mit.edu	37	17	79663007	79663007	+	Silent	SNP	C	C	T			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr17:79663007C>T	uc002kbg.2	+	15	1448	c.1371C>T	c.(1369-1371)CTC>CTT	p.L457L		NM_004712	NP_004703	O14964	HGS_HUMAN	hepatocyte growth factor-regulated tyrosine	457	Interaction with STAM1 (By similarity).|Interaction with SNAP25 and TRAK2 (By similarity).|Interaction with SNX1 (By similarity).				cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of JAK-STAT cascade|regulation of protein catabolic process	cytosol|early endosome membrane|multivesicular body membrane	metal ion binding|protein domain specific binding			ovary(1)	1	all_neural(118;0.0878)|all_lung(278;0.23)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0955)			TGGAGCTGCTCAACCAGCTGG	0.672		NA											4	49					0	0	0	0
ASXL3	80816	broad.mit.edu	37	18	31318686	31318686	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr18:31318686G>A	uc010dmg.1	+	11	1373	c.1318G>A	c.(1318-1320)GAG>AAG	p.E440K	ASXL3_uc002kxq.2_Missense_Mutation_p.E147K	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	440					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						ATTGGAGTCAGAGGATATCTT	0.413		NA											13	49					0	0	0	0
TCF4	6925	broad.mit.edu	37	18	52928732	52928732	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr18:52928732G>T	uc002lfz.2	-	12	1567	c.955C>A	c.(955-957)CAG>AAG	p.Q319K	TCF4_uc002lfw.3_Missense_Mutation_p.Q159K|TCF4_uc010xdu.1_Missense_Mutation_p.Q189K|TCF4_uc010xdv.1_Missense_Mutation_p.Q189K|TCF4_uc002lfx.2_Missense_Mutation_p.Q248K|TCF4_uc010xdw.1_Missense_Mutation_p.Q189K|TCF4_uc002lfy.2_Missense_Mutation_p.Q277K|TCF4_uc010xdx.1_Missense_Mutation_p.Q295K|TCF4_uc010dph.1_Missense_Mutation_p.Q319K|TCF4_uc010xdy.1_Missense_Mutation_p.Q295K|TCF4_uc002lga.2_Missense_Mutation_p.Q421K|TCF4_uc002lgb.1_Missense_Mutation_p.Q159K|TCF4_uc010dpi.2_Missense_Mutation_p.Q325K|TCF4_uc002lfv.2_Missense_Mutation_p.Q103K	NM_003199	NP_003190	P15884	ITF2_HUMAN	transcription factor 4 isoform b	319					positive regulation of neuron differentiation|protein-DNA complex assembly|transcription initiation from RNA polymerase II promoter	transcription factor complex	E-box binding|protein C-terminus binding|protein heterodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding RNA polymerase recruiting transcription factor activity|TFIIB-class binding transcription factor activity|TFIIB-class transcription factor binding			ovary(1)|lung(1)	2				Colorectal(16;0.00108)|READ - Rectum adenocarcinoma(59;0.0649)|COAD - Colon adenocarcinoma(17;0.0718)		TCTCCAGTCTGGGAGCTGCCG	0.458		NA											43	227					8.17e-37	9.14e-37	1	0
MALT1	10892	broad.mit.edu	37	18	56402442	56402442	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr18:56402442G>C	uc002lhm.1	+	13	1742	c.1484G>C	c.(1483-1485)GGA>GCA	p.G495A	MALT1_uc002lhn.1_Missense_Mutation_p.G484A	NM_006785	NP_006776	Q9UDY8	MALT1_HUMAN	mucosa associated lymphoid tissue lymphoma	495	Caspase-like.				activation of NF-kappaB-inducing kinase activity|anti-apoptosis|nuclear export|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of protein ubiquitination|positive regulation of T cell cytokine production|protein oligomerization|proteolysis|T cell receptor signaling pathway	CBM complex|cytosol|nucleus|perinuclear region of cytoplasm	cysteine-type endopeptidase activity|protein self-association|signal transducer activity|ubiquitin-protein ligase activity			ovary(2)|lung(1)|central_nervous_system(1)	4						aggtGTCAAGGAGCAGAAGCT	0.169		NA	T	BIRC3	MALT								4	22					0	0	0	0
C3	718	broad.mit.edu	37	19	6697749	6697749	+	Silent	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr19:6697749G>A	uc002mfm.2	-	20	2559	c.2497C>T	c.(2497-2499)CTG>TTG	p.L833L		NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor	833					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		GGTAGCCGCAGGTCGATGAAG	0.567		NA											3	33					0	0	0	0
FBN3	84467	broad.mit.edu	37	19	8137035	8137035	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr19:8137035G>A	uc002mjf.2	-	62	8006	c.7985C>T	c.(7984-7986)CCG>CTG	p.P2662L	FBN3_uc002mje.2_Missense_Mutation_p.P458L	NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	2662						proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						CTCTTTGTCCGGGGTGTCCTG	0.662		NA											29	172					0	0	0	0
ANGPTL6	83854	broad.mit.edu	37	19	10204163	10204163	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr19:10204163C>T	uc002mmx.1	-	5	1202	c.1084G>A	c.(1084-1086)GAT>AAT	p.D362N	ANGPTL6_uc002mmy.1_Missense_Mutation_p.D362N	NM_031917	NP_114123	Q8NI99	ANGL6_HUMAN	angiopoietin-like 6 precursor	362	Fibrinogen C-terminal.				angiogenesis|cell differentiation|signal transduction	extracellular space	receptor binding				0			OV - Ovarian serous cystadenocarcinoma(20;3.58e-08)|Epithelial(33;2.5e-05)|all cancers(31;5.96e-05)			GAGAAGCCATCATAGTGGGCA	0.622		NA											12	58					0	0	0	0
ZGLP1	100125288	broad.mit.edu	37	19	10415872	10415872	+	Silent	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr19:10415872G>A	uc002mnw.3	-	4	1587	c.711C>T	c.(709-711)TAC>TAT	p.Y237Y		NM_001103167	NP_001096637	P0C6A0	ZGLP1_HUMAN	GATA like protein-1	237					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						AGCGAGTGCCGTATTTCTTGT	0.562		NA											8	46					0	0	0	0
ELOF1	84337	broad.mit.edu	37	19	11665079	11665079	+	Silent	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr19:11665079G>A	uc002mse.1	-	2	148	c.84C>T	c.(82-84)TTC>TTT	p.F28F	ELOF1_uc002msd.1_Silent_p.F49F	NM_032377	NP_115753	P60002	ELOF1_HUMAN	elongation factor 1 homolog (ELF1, S.	28					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding				0						CGTGGTTGCAGAAGGGGCAGG	0.572		NA											14	114					0	0	0	0
EMR2	30817	broad.mit.edu	37	19	14884783	14884783	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr19:14884783C>T	uc002mzp.1	-	4	622	c.166G>A	c.(166-168)GAG>AAG	p.E56K	EMR2_uc010xnw.1_Missense_Mutation_p.E56K|EMR2_uc002mzo.1_Missense_Mutation_p.E56K|EMR2_uc002mzq.1_Missense_Mutation_p.E56K|EMR2_uc002mzr.1_Missense_Mutation_p.E56K|EMR2_uc002mzs.1_Missense_Mutation_p.E56K|EMR2_uc002mzt.1_Missense_Mutation_p.E56K|EMR2_uc002mzu.1_Missense_Mutation_p.E56K|EMR2_uc010xnx.1_5'Flank|EMR2_uc010xny.1_RNA	NM_013447	NP_038475	Q9UHX3	EMR2_HUMAN	egf-like module containing, mucin-like, hormone	56	Extracellular (Potential).|EGF-like 1.				cell adhesion|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			lung(2)|ovary(1)|skin(1)	4						GTGATGATCTCAGAAAAAGAG	0.602		NA											29	109					0	0	0	0
F2RL3	9002	broad.mit.edu	37	19	17000712	17000712	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr19:17000712G>C	uc002nfa.2	+	2	613	c.438G>C	c.(436-438)GAG>GAC	p.E146D		NM_003950	NP_003941	Q96RI0	PAR4_HUMAN	coagulation factor II (thrombin) receptor-like 3	146	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|platelet activation|positive regulation of release of sequestered calcium ion into cytosol	extracellular region|integral to plasma membrane	thrombin receptor activity				0						CCTTCGGGGAGGCCGCCTGCC	0.706		NA											3	11					0	0	0	0
ZNF599	148103	broad.mit.edu	37	19	35251156	35251156	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr19:35251156G>C	uc010edn.1	-	4	938	c.550C>G	c.(550-552)CAA>GAA	p.Q184E	ZNF599_uc010edm.1_Missense_Mutation_p.Q147E	NM_001007248	NP_001007249	Q96NL3	ZN599_HUMAN	zinc finger protein 599	184					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2	all_lung(56;1.13e-07)|Lung NSC(56;1.81e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.138)			CCTGGTCCTTGAGAGTCACAC	0.473		NA											7	127					0	0	0	0
LGI4	163175	broad.mit.edu	37	19	35616221	35616221	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr19:35616221G>A	uc002nxx.2	-	9	2084	c.1490C>T	c.(1489-1491)CCG>CTG	p.P497L	LGI4_uc002nxy.1_Missense_Mutation_p.P325L|LGI4_uc002nxz.1_3'UTR	NM_139284	NP_644813	Q8N135	LGI4_HUMAN	leucine-rich repeat LGI family, member 4	497						extracellular region				pancreas(1)	1	all_lung(56;7.56e-09)|Lung NSC(56;1.1e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.54e-20)|OV - Ovarian serous cystadenocarcinoma(14;1.33e-18)|all cancers(14;4.27e-17)|LUSC - Lung squamous cell carcinoma(66;0.0849)			CACCAGGGCCGGAGGCCCCAG	0.642		NA											10	51					0	0	0	0
CYP2B6	1555	broad.mit.edu	37	19	41522664	41522664	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr19:41522664C>G	uc002opr.1	+	9	1415	c.1408C>G	c.(1408-1410)CTG>GTG	p.L470V	CYP2A7_uc002opo.2_Intron|CYP2B6_uc010xvu.1_Missense_Mutation_p.L270V	NM_000767	NP_000758	P20813	CP2B6_HUMAN	cytochrome P450, family 2, subfamily B,	470					cellular ketone metabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2			LUSC - Lung squamous cell carcinoma(20;0.00322)		Bupropion(DB01156)|Butalbital(DB00241)|Carbamazepine(DB00564)|Clopidogrel(DB00758)|Cyclophosphamide(DB00531)|Efavirenz(DB00625)|Ifosfamide(DB01181)|Memantine(DB01043)|Meperidine(DB00454)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Midazolam(DB00683)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicotine(DB00184)|Orphenadrine(DB01173)|Phenytoin(DB00252)|Propofol(DB00818)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Ticlopidine(DB00208)|Troleandomycin(DB01361)	AGACATCGATCTGACACCCCA	0.582		NA											7	24					0	0	0	0
POU2F2	5452	broad.mit.edu	37	19	42600050	42600050	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr19:42600050T>C	uc002osp.2	-	9	762	c.695A>G	c.(694-696)TAC>TGC	p.Y232C	POU2F2_uc002osn.2_Missense_Mutation_p.Y216C|POU2F2_uc002oso.2_Missense_Mutation_p.Y5C|POU2F2_uc002osq.2_Missense_Mutation_p.Y216C|POU2F2_uc002osr.1_Missense_Mutation_p.Y232C	NM_002698	NP_002689	P09086	PO2F2_HUMAN	POU domain, class 2, transcription factor 2	232	POU-specific.				humoral immune response|transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2		Prostate(69;0.059)				GTCGTTGCCGTAGAGCTTGCC	0.652		NA											22	105					0	0	0	0
TRPM4	54795	broad.mit.edu	37	19	49692319	49692319	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr19:49692319C>T	uc002pmw.2	+	14	2062	c.1990C>T	c.(1990-1992)CGT>TGT	p.R664C	TRPM4_uc010emu.2_Missense_Mutation_p.R664C|TRPM4_uc010yak.1_Missense_Mutation_p.R128C|TRPM4_uc002pmx.2_Missense_Mutation_p.R490C|TRPM4_uc010emv.2_Missense_Mutation_p.R549C|TRPM4_uc010yal.1_Missense_Mutation_p.R310C|TRPM4_uc002pmy.2_Missense_Mutation_p.R6C	NM_017636	NP_060106	Q8TD43	TRPM4_HUMAN	transient receptor potential cation channel,	664	Cytoplasmic (Potential).				dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding			ovary(1)|central_nervous_system(1)	2		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)		AGCTGACGCCCGTGCCTTCTT	0.622		NA											25	108					0	0	0	0
RCN3	57333	broad.mit.edu	37	19	50042435	50042435	+	Silent	SNP	C	C	T	rs151007768	byFrequency	TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr19:50042435C>T	uc002poj.2	+	5	1125	c.678C>T	c.(676-678)ATC>ATT	p.I226I		NM_020650	NP_065701	Q96D15	RCN3_HUMAN	reticulocalbin 3, EF-hand calcium binding domain	226	EF-hand 4.					endoplasmic reticulum lumen	calcium ion binding|protein binding			ovary(1)	1		all_lung(116;7.84e-06)|Lung NSC(112;2.8e-05)|all_neural(266;0.0966)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00295)|GBM - Glioblastoma multiforme(134;0.0159)		AGGAGTACATCGGTGAGTGGG	0.577		NA											7	53					0	0	0	0
NLRP7	199713	broad.mit.edu	37	19	55450689	55450689	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr19:55450689C>T	uc002qih.3	-	4	1574	c.1498G>A	c.(1498-1500)GTA>ATA	p.V500I	NLRP7_uc002qig.3_Missense_Mutation_p.V500I|NLRP7_uc002qii.3_Missense_Mutation_p.V500I|NLRP7_uc010esk.2_Missense_Mutation_p.V500I|NLRP7_uc010esl.2_Missense_Mutation_p.V528I	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	500							ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		AGCTTCTGTACGTCCCCGATG	0.567		NA											11	72					0	0	0	0
ZNF417	147687	broad.mit.edu	37	19	58420667	58420667	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr19:58420667T>C	uc002qqq.2	-	3	1178	c.979A>G	c.(979-981)AGA>GGA	p.R327G	ZNF417_uc010yhm.1_Missense_Mutation_p.R284G|ZNF417_uc002qqr.2_Missense_Mutation_p.R326G	NM_152475	NP_689688	Q8TAU3	ZN417_HUMAN	zinc finger protein 417	327	C2H2-type 5; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0151)		CCATATTCTCTACACTCATAA	0.463		NA											12	257					0	0	0	0
TMEM178	130733	broad.mit.edu	37	2	39893244	39893244	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr2:39893244G>C	uc002rrt.2	+	1	155	c.130G>C	c.(130-132)GAG>CAG	p.E44Q	TMEM178_uc010fam.1_Missense_Mutation_p.E44Q	NM_152390	NP_689603	Q8NBL3	TM178_HUMAN	transmembrane protein 178 precursor	44	Extracellular (Potential).					integral to membrane					0		all_hematologic(82;0.248)				GGAGAGCTGCGAGCGCAGCCG	0.642		NA											5	24					0	0	0	0
CCDC88A	55704	broad.mit.edu	37	2	55546086	55546086	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr2:55546086C>G	uc002ryv.2	-	19	4056	c.3214G>C	c.(3214-3216)GAG>CAG	p.E1072Q	CCDC88A_uc010yoz.1_Missense_Mutation_p.E1073Q|CCDC88A_uc010ypa.1_Missense_Mutation_p.E1072Q|CCDC88A_uc002ryu.2_Missense_Mutation_p.E355Q|CCDC88A_uc002rys.2_Missense_Mutation_p.E58Q|CCDC88A_uc002ryw.2_Missense_Mutation_p.E356Q|CCDC88A_uc010fby.1_5'UTR	NM_001135597	NP_001129069	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A isoform 1	1073	Potential.				activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			ovary(2)|skin(2)	4						TTCTGTGTCTCAAGTTGCTTC	0.383		NA											4	53					0	0	0	0
RGPD4	285190	broad.mit.edu	37	2	108487257	108487257	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr2:108487257C>T	uc010ywk.1	+	20	2879	c.2797C>T	c.(2797-2799)CAA>TAA	p.Q933*	RGPD4_uc002tdu.2_Nonsense_Mutation_p.Q120*|RGPD4_uc010ywl.1_RNA	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	933					intracellular transport		binding			skin(2)	2						ACCAGGAAATCAAGAAAAGGA	0.413		NA											54	258					0	0	0	0
GALNT3	2591	broad.mit.edu	37	2	166615260	166615260	+	Silent	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr2:166615260G>A	uc010fph.1	-	6	1575	c.1188C>T	c.(1186-1188)TTC>TTT	p.F396F	GALNT3_uc010fpi.1_Silent_p.F396F	NM_004482	NP_004473	Q14435	GALT3_HUMAN	polypeptide N-acetylgalactosaminyltransferase 3	396	Catalytic subdomain B.|Lumenal (Potential).				protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	Golgi cisterna membrane|integral to membrane|membrane fraction|nucleus|perinuclear region of cytoplasm	calcium ion binding|manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(2)|ovary(1)	3						AACTTACTCTGAAAGACATTT	0.308		NA											8	54					0	0	0	0
STK39	27347	broad.mit.edu	37	2	169023849	169023849	+	Silent	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr2:169023849G>A	uc002uea.2	-	3	550	c.390C>T	c.(388-390)GTC>GTT	p.V130V		NM_013233	NP_037365	Q9UEW8	STK39_HUMAN	serine threonine kinase 39 (STE20/SPS1 homolog,	130	Protein kinase.				response to stress	cytoplasm|nucleus	ATP binding|protein binding|receptor signaling protein serine/threonine kinase activity			central_nervous_system(1)|skin(1)	2						GTTCATCTTTGACCACAAAAG	0.378		NA											4	37					0	0	0	0
LRP2	4036	broad.mit.edu	37	2	170101261	170101261	+	Silent	SNP	C	C	T			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr2:170101261C>T	uc002ues.2	-	22	3585	c.3372G>A	c.(3370-3372)AAG>AAA	p.K1124K	LRP2_uc010zdf.1_Silent_p.K987K	NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	1124	LDL-receptor class A 10.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	AGACCCAGTTCTTTGAGATAC	0.493		NA											20	114					0	0	0	0
WIPF1	7456	broad.mit.edu	37	2	175432655	175432655	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr2:175432655C>G	uc002uiy.2	-	7	1608	c.1276G>C	c.(1276-1278)GGG>CGG	p.G426R	uc002uiw.2_Intron|uc002uix.1_Intron|WIPF1_uc002uja.2_Missense_Mutation_p.G426R|WIPF1_uc010fqt.1_Missense_Mutation_p.G426R|WIPF1_uc002uiz.2_Missense_Mutation_p.G426R|WIPF1_uc002ujb.1_Missense_Mutation_p.G426R	NM_003387	NP_003378	O43516	WIPF1_HUMAN	WAS/WASL interacting protein family, member 1	426	Pro-rich.				actin polymerization or depolymerization|protein complex assembly	cytoplasmic membrane-bounded vesicle	actin binding|profilin binding			ovary(1)|skin(1)	2						GGAGGTGCCCCAGCACTGGGC	0.602		NA											10	64					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179414566	179414566	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr2:179414566C>T	uc010zfg.1	-	287	84403	c.84179G>A	c.(84178-84180)AGA>AAA	p.R28060K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R21755K|TTN_uc010zfi.1_Missense_Mutation_p.R21688K|TTN_uc010zfj.1_Missense_Mutation_p.R21563K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	28987							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATTGGTGAATCTTATTGGCCC	0.403		NA											5	109					0	0	0	0
AOX1	316	broad.mit.edu	37	2	201534448	201534448	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr2:201534448G>A	uc002uvx.2	+	34	4050	c.3949G>A	c.(3949-3951)GAC>AAC	p.D1317N	AOX1_uc010zhf.1_Missense_Mutation_p.D873N|AOX1_uc010fsu.2_Missense_Mutation_p.D683N	NM_001159	NP_001150	Q06278	ADO_HUMAN	aldehyde oxidase 1	1317					inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity	p.D1317V(1)		ovary(4)|pancreas(1)|skin(1)	6					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	GGCCTGTGAAGACAAGTTCAC	0.448		NA											17	114					0	0	0	0
PNKD	25953	broad.mit.edu	37	2	219204763	219204763	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr2:219204763C>A	uc002vhn.2	+	4	508	c.364C>A	c.(364-366)CTT>ATT	p.L122I	PNKD_uc002vhq.2_Missense_Mutation_p.L98I	NM_015488	NP_056303	Q8N490	PNKD_HUMAN	myofibrillogenesis regulator 1 isoform 1	122						membrane|mitochondrion|nucleus	hydroxyacylglutathione hydrolase activity|zinc ion binding				0		Renal(207;0.0474)		Epithelial(149;7.33e-07)|all cancers(144;0.000133)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGTGAAGGTGCTTCCCATCCC	0.652		NA											13	63					0.000151284	0.000162691	1	0
EPHA4	2043	broad.mit.edu	37	2	222298867	222298867	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr2:222298867G>A	uc002vmq.2	-	14	2533	c.2491C>T	c.(2491-2493)CAA>TAA	p.Q831*	EPHA4_uc002vmr.2_Nonsense_Mutation_p.Q831*|EPHA4_uc010zlm.1_Nonsense_Mutation_p.Q772*|EPHA4_uc010zln.1_Nonsense_Mutation_p.Q831*	NM_004438	NP_004429	P54764	EPHA4_HUMAN	ephrin receptor EphA4 precursor	831	Protein kinase.|Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(6)|large_intestine(2)|central_nervous_system(2)|urinary_tract(1)|skin(1)	12		Renal(207;0.0183)		Epithelial(121;5.38e-09)|all cancers(144;2.47e-06)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(261;0.0154)		CTTACATCTTGATTGGACATA	0.408		NA											9	70					0	0	0	0
CHRNG	1146	broad.mit.edu	37	2	233405103	233405103	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr2:233405103G>A	uc002vsx.1	+	3	229	c.208G>A	c.(208-210)GAA>AAA	p.E70K	CHRNG_uc010fyd.2_Missense_Mutation_p.E70K|CHRNG_uc010fye.1_Missense_Mutation_p.E70K	NM_005199	NP_005190	P07510	ACHG_HUMAN	cholinergic receptor, nicotinic, gamma	70	Extracellular (Potential).				muscle contraction	cell junction|postsynaptic membrane	acetylcholine receptor activity				0		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;6.39e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00079)|LUSC - Lung squamous cell carcinoma(224;0.00757)|Lung(119;0.0086)		CGAGCGAGAGGAAGCCCTCAC	0.632		NA											17	78					0	0	0	0
SH3BP4	23677	broad.mit.edu	37	2	235949960	235949960	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr2:235949960G>A	uc002vvp.2	+	4	940	c.547G>A	c.(547-549)GAG>AAG	p.E183K	SH3BP4_uc010fym.2_Missense_Mutation_p.E183K|SH3BP4_uc002vvq.2_Missense_Mutation_p.E183K	NM_014521	NP_055336	Q9P0V3	SH3B4_HUMAN	SH3-domain binding protein 4	183					endocytosis	clathrin-coated vesicle|coated pit|nucleus	protein binding			skin(3)|ovary(1)	4		Breast(86;0.000332)|Renal(207;0.00339)|all_lung(227;0.00458)|all_hematologic(139;0.0296)|Lung NSC(271;0.0419)		Epithelial(121;7.66e-20)|BRCA - Breast invasive adenocarcinoma(100;0.000402)|Lung(119;0.00299)|LUSC - Lung squamous cell carcinoma(224;0.00645)|GBM - Glioblastoma multiforme(43;0.237)		CAGCCTGGATGAGCTGAATCC	0.493		NA											29	115					0	0	0	0
TGM6	343641	broad.mit.edu	37	20	2378615	2378615	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr20:2378615G>A	uc002wfy.1	+	5	656	c.595G>A	c.(595-597)GGT>AGT	p.G199S	TGM6_uc010gal.1_Missense_Mutation_p.G199S	NM_198994	NP_945345	O95932	TGM3L_HUMAN	transglutaminase 6	199					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(3)|skin(1)	4					L-Glutamine(DB00130)	TCGAAGCCCCGGTCACCAAAA	0.587		NA											6	69					0	0	0	0
PAK7	57144	broad.mit.edu	37	20	9520219	9520219	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr20:9520219C>G	uc002wnl.2	-	11	2595	c.2050G>C	c.(2050-2052)GAG>CAG	p.E684Q	PAK7_uc002wnk.2_Missense_Mutation_p.E684Q|PAK7_uc002wnj.2_Missense_Mutation_p.E684Q|PAK7_uc010gby.1_Missense_Mutation_p.E597Q	NM_020341	NP_065074	Q9P286	PAK7_HUMAN	p21-activated kinase 7	684	Protein kinase.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(11)|skin(5)|central_nervous_system(3)|ovary(2)|large_intestine(1)|stomach(1)	23			COAD - Colon adenocarcinoma(9;0.194)			TGAGAGGGCTCCCTCACCAAC	0.507		NA											26	152					0	0	0	0
CST9	128822	broad.mit.edu	37	20	23586433	23586433	+	Silent	SNP	G	G	C			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr20:23586433G>C	uc002wtl.2	-	1	178	c.69C>G	c.(67-69)CTC>CTG	p.L23L		NM_001008693	NP_001008693	Q5W186	CST9_HUMAN	cystatin 9 precursor	23						extracellular region	cysteine-type endopeptidase inhibitor activity			ovary(1)	1	Colorectal(13;0.0993)					AAGTCACCAGGAGCTGGAAGC	0.532		NA											14	104					0	0	0	0
RBM39	9584	broad.mit.edu	37	20	34302145	34302145	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr20:34302145G>A	uc002xeb.2	-	11	1402	c.1058C>T	c.(1057-1059)ACA>ATA	p.T353I	RBM39_uc002xdz.2_Missense_Mutation_p.T329I|RBM39_uc002xea.2_Missense_Mutation_p.T196I|RBM39_uc010gfn.2_Missense_Mutation_p.T196I|RBM39_uc010zvm.1_Missense_Mutation_p.T331I|RBM39_uc002xeg.2_Missense_Mutation_p.T331I|RBM39_uc002xec.2_Missense_Mutation_p.T353I|RBM39_uc002xed.2_Missense_Mutation_p.T71I|RBM39_uc002xee.2_Missense_Mutation_p.T196I|RBM39_uc002xef.2_Missense_Mutation_p.T196I|RBM39_uc010zvn.1_Missense_Mutation_p.T196I	NM_184234	NP_909122	Q14498	RBM39_HUMAN	RNA binding motif protein 39 isoform a	353	Activating domain (By similarity).|Interaction with JUN (By similarity).				mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	centrosome|nuclear speck	nucleotide binding|protein binding|RNA binding			ovary(1)|central_nervous_system(1)	2	all_epithelial(2;0.00295)|Lung NSC(9;0.00453)|Breast(12;0.00544)|all_lung(11;0.00676)					ACGACCAGTTGTTCCCAAATC	0.408		NA											8	66					0	0	0	0
KIAA1755	85449	broad.mit.edu	37	20	36869389	36869389	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr20:36869389C>G	uc002xhy.1	-	3	1416	c.1144G>C	c.(1144-1146)GAC>CAC	p.D382H	KIAA1755_uc002xhz.1_Missense_Mutation_p.D382H	NM_001029864	NP_001025035	Q5JYT7	K1755_HUMAN	hypothetical protein LOC85449	382										ovary(4)|pancreas(1)	5		Myeloproliferative disorder(115;0.00874)				GAGGCACAGTCCAGTGCGTCC	0.547		NA											30	172					0	0	0	0
GNAS	2778	broad.mit.edu	37	20	57429096	57429096	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr20:57429096C>T	uc002xzw.2	+	1	1061	c.776C>T	c.(775-777)GCG>GTG	p.A259V	GNAS_uc002xzt.2_Intron|GNAS_uc002xzu.3_Intron|GNAS_uc010gjq.2_Intron|GNAS_uc002xzv.2_RNA	NM_080425	NP_536350	P63092	GNAS2_HUMAN	GNAS complex locus XLas	Error:Variant_position_missing_in_P63092_after_alignment					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			pituitary(201)|thyroid(35)|ovary(15)|adrenal_gland(9)|liver(7)|large_intestine(5)|parathyroid(5)|kidney(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|testis(1)|stomach(1)|small_intestine(1)|autonomic_ganglia(1)|pancreas(1)	292	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			GCGGCAGTCGCGGCCTCGAGT	0.667		NA	Mis		pituitary adenoma		McCune-Albright syndrome; pseudohypoparathyroidism|type IA		3-Methylglutaconic_Aciduria_and_Myelodysplasia|McCune-Albright_syndrome|Mazabraud_syndrome	TSP Lung(22;0.16)			6	28					0	0	0	0
ARFRP1	10139	broad.mit.edu	37	20	62331810	62331810	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr20:62331810C>G	uc002yga.2	-	7	1158	c.591G>C	c.(589-591)CAG>CAC	p.Q197H	ARFRP1_uc002ygc.2_Missense_Mutation_p.Q197H|ARFRP1_uc002ygh.3_3'UTR|ARFRP1_uc011abf.1_3'UTR|ARFRP1_uc011abg.1_3'UTR|ARFRP1_uc002yge.2_RNA|ARFRP1_uc002ygd.2_RNA|ARFRP1_uc002ygf.2_Missense_Mutation_p.Q197H|ARFRP1_uc002ygg.2_RNA|ARFRP1_uc011abh.1_RNA	NM_003224	NP_003215	Q13795	ARFRP_HUMAN	ADP-ribosylation factor related protein 1	197					small GTPase mediated signal transduction	Golgi apparatus|membrane fraction	GTP binding|GTPase activity			breast(1)|skin(1)	2	all_cancers(38;9.53e-13)|all_epithelial(29;2.64e-14)|Lung NSC(23;7e-10)|all_lung(23;2.53e-09)		Epithelial(9;4.09e-08)|all cancers(9;1.7e-07)|OV - Ovarian serous cystadenocarcinoma(5;0.0102)			TGATGTCCCTCTGCCGCGGCG	0.682		NA											3	62					0	0	0	0
SON	6651	broad.mit.edu	37	21	34923116	34923116	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr21:34923116C>T	uc002yse.1	+	3	1628	c.1579C>T	c.(1579-1581)CAT>TAT	p.H527Y	SON_uc002ysb.1_Missense_Mutation_p.H527Y|SON_uc002ysc.2_Missense_Mutation_p.H527Y|SON_uc002ysd.2_5'UTR|SON_uc002ysf.1_Intron|SON_uc002ysg.2_5'Flank	NM_138927	NP_620305	P18583	SON_HUMAN	SON DNA-binding protein isoform F	527					anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			ovary(4)|skin(2)	6						ACATCCTGGGCATCCTGAGGT	0.592		NA											21	125					0	0	0	0
TTC3	7267	broad.mit.edu	37	21	38525425	38525425	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr21:38525425G>C	uc002yvz.2	+	27	2693	c.2588G>C	c.(2587-2589)AGA>ACA	p.R863T	TTC3_uc011aee.1_Missense_Mutation_p.R553T|TTC3_uc002ywa.2_Missense_Mutation_p.R863T|TTC3_uc002ywb.2_Missense_Mutation_p.R863T|TTC3_uc010gnf.2_Missense_Mutation_p.R628T|TTC3_uc002ywc.2_Missense_Mutation_p.R553T|TTC3_uc011aed.1_Missense_Mutation_p.R553T	NM_001001894	NP_001001894	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	863					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(3)|ovary(2)|lung(2)|breast(2)	9		Myeloproliferative disorder(46;0.0412)				TTTTCTAGCAGAAATTTTCTA	0.348		NA											18	86					0	0	0	0
MYH9	4627	broad.mit.edu	37	22	36708234	36708234	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr22:36708234C>T	uc003apg.2	-	14	1819	c.1588G>A	c.(1588-1590)GAG>AAG	p.E530K	MYH9_uc003aph.1_Missense_Mutation_p.E394K	NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	530	Myosin head-like.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						CAGCACTCCTCGTCCAGCAGG	0.637		NA	T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				12	65					0	0	0	0
MST1	4485	broad.mit.edu	37	3	49722464	49722464	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr3:49722464G>C	uc003cxg.2	-	14	1675	c.1603C>G	c.(1603-1605)CGG>GGG	p.R535G		NM_020998	NP_066278	P26927	HGFL_HUMAN	macrophage stimulating 1 (hepatocyte growth	521	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		AAGCACTGCCGGGCAGTCAGT	0.592		NA											3	18					0	0	0	0
TOPBP1	11073	broad.mit.edu	37	3	133368367	133368367	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr3:133368367G>C	uc003eps.2	-	10	1496	c.1364C>G	c.(1363-1365)TCA>TGA	p.S455*		NM_007027	NP_008958	Q92547	TOPB1_HUMAN	topoisomerase (DNA) II binding protein 1	455					DNA repair|response to ionizing radiation	microtubule organizing center|PML body|spindle pole	DNA binding|protein C-terminus binding			ovary(2)|kidney(2)|skin(1)|lung(1)|pancreas(1)	7						AGGCTTATGTGAAACTGGAAT	0.393		NA						Other_conserved_DNA_damage_response_genes					35	124					0	0	0	0
EPHB1	2047	broad.mit.edu	37	3	134911464	134911464	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr3:134911464G>C	uc003eqt.2	+	11	2149	c.1929G>C	c.(1927-1929)AAG>AAC	p.K643N	EPHB1_uc003equ.2_Missense_Mutation_p.K204N	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	643	Cytoplasmic (Potential).|Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30						TGCCAGGCAAGAGGGAAATCT	0.527		NA											10	37					0	0	0	0
ESYT3	83850	broad.mit.edu	37	3	138187688	138187688	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr3:138187688G>A	uc003esk.2	+	14	1625	c.1399G>A	c.(1399-1401)GAA>AAA	p.E467K	ESYT3_uc010hug.2_RNA	NM_031913	NP_114119	A0FGR9	ESYT3_HUMAN	family with sequence similarity 62 (C2 domain	467	C2 2.					integral to membrane|plasma membrane					0						CCTGAATGGTGAATATCGAGC	0.463		NA											44	363					0	0	0	0
ATR	545	broad.mit.edu	37	3	142241603	142241603	+	Silent	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr3:142241603G>A	uc003eux.3	-	23	4355	c.4233C>T	c.(4231-4233)AGC>AGT	p.S1411S		NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	1411					cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20						CTTGAGCTCGGCTATTATCAG	0.358		NA						Other_conserved_DNA_damage_response_genes					42	121					0	0	0	0
ATR	545	broad.mit.edu	37	3	142285073	142285073	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr3:142285073G>C	uc003eux.3	-	3	304	c.182C>G	c.(181-183)TCT>TGT	p.S61C		NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	61					cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20						GGTTGGCTGAGAGTCAGTTTT	0.378		NA						Other_conserved_DNA_damage_response_genes					4	36					0	0	0	0
C3orf79	152118	broad.mit.edu	37	3	153202424	153202424	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr3:153202424C>G	uc003ezt.2	+	1	141	c.79C>G	c.(79-81)CTT>GTT	p.L27V		NM_001101337	NP_001094807	P0CE67	CC079_HUMAN	chromosome 3 open reading frame 79	27											0						CAGTTGCCATCTTCTGCCTAC	0.413		NA											19	236					0	0	0	0
PLCH1	23007	broad.mit.edu	37	3	155200325	155200325	+	Silent	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr3:155200325G>A	uc011bok.1	-	23	3791	c.3514C>T	c.(3514-3516)CTG>TTG	p.L1172L	PLCH1_uc011boj.1_3'UTR|PLCH1_uc011bol.1_Silent_p.L1134L	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	1172					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			CTCTCCTGCAGAATTGCAGTT	0.458		NA											8	42					0	0	0	0
DGKG	1608	broad.mit.edu	37	3	185882740	185882740	+	Silent	SNP	G	G	A	rs137961016	byFrequency	TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr3:185882740G>A	uc003fqa.2	-	23	2700	c.2163C>T	c.(2161-2163)ACC>ACT	p.T721T	DGKG_uc003fqb.2_Silent_p.T682T|DGKG_uc003fqc.2_Silent_p.T696T|DGKG_uc011brx.1_Silent_p.T662T	NM_001346	NP_001337	P49619	DGKG_HUMAN	diacylglycerol kinase gamma isoform 1	721					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	all_cancers(143;3.26e-12)|Ovarian(172;0.0315)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)	GBM - Glioblastoma multiforme(93;0.0657)	Phosphatidylserine(DB00144)	TCTTCAGGCCGGTGTAGATCT	0.587		NA											13	52					0	0	0	0
FETUB	26998	broad.mit.edu	37	3	186358276	186358276	+	Silent	SNP	C	C	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr3:186358276C>A	uc010hyq.2	+	2	288	c.27C>A	c.(25-27)CTC>CTA	p.L9L	FETUB_uc011brz.1_Intron|FETUB_uc003fqn.2_Silent_p.L9L|FETUB_uc003fqo.2_Translation_Start_Site|FETUB_uc010hyr.2_Silent_p.L9L|FETUB_uc010hys.2_Translation_Start_Site|FETUB_uc003fqp.3_Silent_p.L9L	NM_014375	NP_055190	Q9UGM5	FETUB_HUMAN	fetuin B precursor	9				L -> P (in Ref. 6; AAH74734).		extracellular space	cysteine-type endopeptidase inhibitor activity			ovary(1)|lung(1)	2	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0479)		CCCTGGCACTCTGCATCCTAG	0.597		NA											77	209					1.41e-51	1.58e-51	1	0
ST6GAL1	6480	broad.mit.edu	37	3	186793540	186793540	+	Silent	SNP	C	C	T			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr3:186793540C>T	uc003frb.2	+	8	1602	c.1170C>T	c.(1168-1170)ATC>ATT	p.I390I	ST6GAL1_uc003frc.2_Silent_p.I159I|ST6GAL1_uc003frd.2_Silent_p.I390I	NM_173216	NP_775323	P15907	SIAT1_HUMAN	ST6 beta-galactosamide	390	Lumenal (Potential).				humoral immune response|post-translational protein modification|protein N-linked glycosylation via asparagine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			central_nervous_system(1)	1	all_cancers(143;2.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;8.53e-19)	GBM - Glioblastoma multiforme(93;0.0939)		ATGAGGACATCTACCTGCTTG	0.507		NA											5	81					0	0	0	0
RTP1	132112	broad.mit.edu	37	3	186917561	186917561	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr3:186917561C>G	uc003frg.2	+	2	525	c.495C>G	c.(493-495)TGC>TGG	p.C165W		NM_153708	NP_714919	P59025	RTP1_HUMAN	receptor transporting protein 1	165	Cytoplasmic (Potential).				protein insertion into membrane	cell surface|integral to membrane|plasma membrane	olfactory receptor binding			ovary(2)|breast(1)	3	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.56e-18)	GBM - Glioblastoma multiforme(93;0.0269)		GCGAGCAGTGCTACGGCGAGC	0.687		NA											21	29					0	0	0	0
C3orf59	151963	broad.mit.edu	37	3	192516720	192516720	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr3:192516720G>C	uc011bsp.1	-	2	1252	c.931C>G	c.(931-933)CAG>GAG	p.Q311E		NM_178496	NP_848591	Q8IYB1	M21D2_HUMAN	hypothetical protein LOC151963	311											0	all_cancers(143;1.56e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.8e-18)|LUSC - Lung squamous cell carcinoma(58;8.04e-06)|Lung(62;8.62e-06)	GBM - Glioblastoma multiforme(46;3.86e-05)		TTGCAGGCCTGATAGGCCTGC	0.557		NA											4	46					0	0	0	0
IQCG	84223	broad.mit.edu	37	3	197665630	197665630	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr3:197665630C>A	uc003fyo.2	-	4	450	c.304G>T	c.(304-306)GAA>TAA	p.E102*	IQCG_uc003fyn.2_Nonsense_Mutation_p.E4*|IQCG_uc003fyp.2_Nonsense_Mutation_p.E102*|IQCG_uc003fyq.3_Nonsense_Mutation_p.E102*	NM_001134435	NP_001127907	Q9H095	IQCG_HUMAN	IQ motif containing G	102											0	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;7.19e-24)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.149)		TTCGTTCCTTCTAGATTCATT	0.338		NA											27	184					2.45e-14	2.72e-14	1	0
DGKQ	1609	broad.mit.edu	37	4	957073	957073	+	Silent	SNP	C	C	T			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr4:957073C>T	uc003gbw.2	-	16	1814	c.1740G>A	c.(1738-1740)GCG>GCA	p.A580A	DGKQ_uc010ibn.2_Silent_p.A567A	NM_001347	NP_001338	P52824	DGKQ_HUMAN	diacylglycerol kinase, theta	580					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|platelet activation|protein kinase C signaling cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to ATP|thrombin receptor signaling pathway	cytoskeleton|cytosol|nuclear speck|plasma membrane	activating transcription factor binding|ATP binding|diacylglycerol kinase activity|kinase binding|metal ion binding|phospholipase binding			kidney(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			GGGGCAGCTTCGCGTGCTGAC	0.652		NA											10	38					0	0	0	0
ADRA2C	152	broad.mit.edu	37	4	3768939	3768939	+	Silent	SNP	C	C	T			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr4:3768939C>T	uc003ghm.2	+	1	644	c.606C>T	c.(604-606)TGC>TGT	p.C202C	ADRA2C_uc010icx.2_Silent_p.C202C	NM_000683	NP_000674	P18825	ADA2C_HUMAN	alpha-2C-adrenergic receptor	202	Extracellular (By similarity).				activation of MAPK activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cell-cell signaling|energy reserve metabolic process|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|negative regulation of epinephrine secretion|negative regulation of norepinephrine secretion|positive regulation of neuron differentiation|regulation of insulin secretion	endosome|integral to plasma membrane	alpha-2A adrenergic receptor binding|alpha2-adrenergic receptor activity|epinephrine binding|protein heterodimerization activity|protein homodimerization activity				0				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)	Bethanidine(DB00217)|Brimonidine(DB00484)|Debrisoquin(DB04840)|Fenoldopam(DB00800)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Lofexidine(DB04948)|Norepinephrine(DB00368)|Yohimbine(DB01392)	ACCCGCAGTGCGGCCTCAACG	0.672		NA											3	25					0	0	0	0
WDR19	57728	broad.mit.edu	37	4	39276495	39276495	+	Silent	SNP	C	C	T			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr4:39276495C>T	uc003gtv.2	+	33	3787	c.3633C>T	c.(3631-3633)TTC>TTT	p.F1211F	WDR19_uc011byi.1_Silent_p.F1051F|WDR19_uc003gtw.1_Silent_p.F808F	NM_025132	NP_079408	Q8NEZ3	WDR19_HUMAN	WD repeat domain 19	1211					cell projection organization	microtubule basal body|motile cilium|photoreceptor connecting cilium	binding			large_intestine(1)	1						ACTCTGCTTTCAGCTTCGCAG	0.488		NA											8	96					0	0	0	0
GUF1	60558	broad.mit.edu	37	4	44700691	44700691	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr4:44700691C>G	uc003gww.3	+	17	2210	c.2003C>G	c.(2002-2004)TCT>TGT	p.S668C	GUF1_uc011bza.1_Missense_Mutation_p.S75C	NM_021927	NP_068746	Q8N442	GUF1_HUMAN	GUF1 GTPase homolog	668					translation	mitochondrial inner membrane	GTP binding|GTPase activity			upper_aerodigestive_tract(1)	1						ACACAATCTTCTAAATAATTG	0.308		NA											9	26					0	0	0	0
RUFY3	22902	broad.mit.edu	37	4	71628306	71628306	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr4:71628306G>C	uc003hfq.2	+	2	844	c.249G>C	c.(247-249)TTG>TTC	p.L83F	RUFY3_uc003hfp.3_Missense_Mutation_p.L143F|RUFY3_uc011cax.1_Missense_Mutation_p.L101F|RUFY3_uc003hfr.2_Missense_Mutation_p.L83F|RUFY3_uc011cay.1_Missense_Mutation_p.L19F	NM_014961	NP_055776	Q7L099	RUFY3_HUMAN	RUN and FYVE domain containing 3 isoform 2	83					negative regulation of axonogenesis	filopodium|growth cone					0		all_hematologic(202;0.248)	Lung(101;0.235)			TCAAGGGCTTGATTGAATCAG	0.473		NA											29	200					0	0	0	0
GK2	2712	broad.mit.edu	37	4	80328806	80328806	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr4:80328806G>C	uc003hlu.2	-	1	567	c.549C>G	c.(547-549)ATC>ATG	p.I183M		NM_033214	NP_149991	Q14410	GLPK2_HUMAN	glycerol kinase 2	183					glycerol-3-phosphate metabolic process	mitochondrial outer membrane	ATP binding|glycerol kinase activity			ovary(2)|skin(2)	4						TCAAACTCCAGATAAGCCATG	0.403		NA											4	80					0	0	0	0
THAP9	79725	broad.mit.edu	37	4	83838784	83838784	+	Silent	SNP	G	G	C			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr4:83838784G>C	uc003hnt.2	+	5	1538	c.1419G>C	c.(1417-1419)CTG>CTC	p.L473L	THAP9_uc003hns.1_Silent_p.L329L|THAP9_uc003hnu.1_RNA|THAP9_uc003hnv.2_Silent_p.L190L	NM_024672	NP_078948	Q9H5L6	THAP9_HUMAN	THAP domain containing 9	473							DNA binding|metal ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	5		Hepatocellular(203;0.114)				ATCATGTACTGAAAGTGAATA	0.388		NA											21	104					0	0	0	0
MEPE	56955	broad.mit.edu	37	4	88766888	88766888	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr4:88766888G>A	uc003hqy.2	+	4	907	c.868G>A	c.(868-870)GAA>AAA	p.E290K	MEPE_uc010ikn.2_Missense_Mutation_p.E177K	NM_020203	NP_064588	Q9NQ76	MEPE_HUMAN	matrix, extracellular phosphoglycoprotein with	290					skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding			ovary(1)|lung(1)|skin(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000432)		AGGCCCAAGTGAAGCTGAGAG	0.448		NA											9	55					0	0	0	0
FAM13A	10144	broad.mit.edu	37	4	89652580	89652580	+	Splice_Site	SNP	C	C	G			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr4:89652580C>G	uc003hse.1	-	23	3052	c.2844_splice	c.e23-1	p.I948_splice	FAM13A_uc011cdp.1_Splice_Site_p.I50_splice|FAM13A_uc003hsa.1_Splice_Site_p.I391_splice|FAM13A_uc003hsb.1_Splice_Site_p.I622_splice|FAM13A_uc003hsd.1_Splice_Site_p.I594_splice|FAM13A_uc003hsc.1_Splice_Site_p.I608_splice|FAM13A_uc011cdq.1_Splice_Site_p.I594_splice|FAM13A_uc003hsf.1_Splice_Site_p.I534_splice|FAM13A_uc003hsg.1_Intron	NM_014883	NP_055698	O94988	FA13A_HUMAN	family with sequence similarity 13, member A1						regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(1)|liver(1)	2						GAGTTCAGGTCTAAGAGAGAG	0.398		NA											4	31					0	0	0	0
ENPEP	2028	broad.mit.edu	37	4	111397596	111397596	+	Missense_Mutation	SNP	C	C	G	rs147278588		TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr4:111397596C>G	uc003iab.3	+	1	368	c.26C>G	c.(25-27)TCT>TGT	p.S9C		NM_001977	NP_001968	Q07075	AMPE_HUMAN	glutamyl aminopeptidase	9	Cytoplasmic (Potential).				cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			skin(3)|ovary(1)|breast(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	AGAGAGGGCTCTAAGAGATAC	0.433		NA											17	121					0	0	0	0
ANK2	287	broad.mit.edu	37	4	114158298	114158298	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr4:114158298G>C	uc003ibe.3	+	6	739	c.639G>C	c.(637-639)CAG>CAC	p.Q213H	ANK2_uc003ibd.3_Missense_Mutation_p.Q192H|ANK2_uc003ibf.3_Missense_Mutation_p.Q213H|ANK2_uc003ibc.2_Missense_Mutation_p.Q189H|ANK2_uc011cgb.1_Missense_Mutation_p.Q228H	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	213	ANK 6.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TTCTGCTTCAGAATGACCACA	0.488		NA											11	125					0	0	0	0
TNIP3	79931	broad.mit.edu	37	4	122068285	122068285	+	Silent	SNP	T	T	C			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr4:122068285T>C	uc010ing.2	-	7	850	c.654A>G	c.(652-654)CGA>CGG	p.R218R	TNIP3_uc010inh.2_Silent_p.R218R|TNIP3_uc011cgj.1_Silent_p.R276R	NM_024873	NP_079149	Q96KP6	TNIP3_HUMAN	TNFAIP3 interacting protein 3	218	Potential.									ovary(1)	1						TAAGTCTCTCTCGATCCGATC	0.373		NA											7	70					0	0	0	0
QRFPR	84109	broad.mit.edu	37	4	122301463	122301463	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr4:122301463C>A	uc010inj.1	-	1	719	c.340G>T	c.(340-342)GGT>TGT	p.G114C	QRFPR_uc010ink.1_RNA|QRFPR_uc003ids.2_Missense_Mutation_p.G114C|QRFPR_uc010inl.1_Missense_Mutation_p.G114C	NM_198179	NP_937822	Q96P65	QRFPR_HUMAN	G protein-coupled receptor 103	114	Extracellular (Potential).					plasma membrane	neuropeptide Y receptor activity				0						CGACTCTTACCCCCCAGCCAG	0.443		NA											12	73					0.000978159	0.00103547	1	0
MFSD8	256471	broad.mit.edu	37	4	128842692	128842692	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr4:128842692C>A	uc003ifp.2	-	12	1500	c.1337G>T	c.(1336-1338)GGA>GTA	p.G446V	MFSD8_uc011cgu.1_Missense_Mutation_p.G401V|MFSD8_uc011cgv.1_3'UTR	NM_152778	NP_689991	Q8NHS3	MFSD8_HUMAN	major facilitator superfamily domain containing	446	Cytoplasmic (Potential).				cell death|transmembrane transport	integral to membrane|lysosomal membrane				ovary(1)|liver(1)	2						AGGTTTTGGTCCTAGAATTTT	0.378		NA											6	50					0.00116845	0.0012321	1	0
MAML3	55534	broad.mit.edu	37	4	140811093	140811093	+	Silent	SNP	C	C	T			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr4:140811093C>T	uc003ihz.1	-	2	2249	c.1497G>A	c.(1495-1497)CAG>CAA	p.Q499Q	MAML3_uc011chd.1_Intron	NM_018717	NP_061187	Q96JK9	MAML3_HUMAN	mastermind-like 3	499	Gln-rich.				Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity			ovary(1)	1	all_hematologic(180;0.162)					gctgctgctgctgctgctgct	0.264		NA											3	46					0	0	0	0
GLRB	2743	broad.mit.edu	37	4	158057783	158057783	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr4:158057783C>T	uc003ipj.2	+	5	662	c.460C>T	c.(460-462)CAT>TAT	p.H154Y		NM_000824	NP_000815	P48167	GLRB_HUMAN	glycine receptor, beta isoform A precursor	154	Extracellular (Probable).				nervous system development|neuropeptide signaling pathway|startle response	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|protein binding|receptor activity			skin(2)	2	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.0564)|COAD - Colon adenocarcinoma(41;0.0642)|Kidney(143;0.0707)	Glycine(DB00145)	TGCCAATTTTCATGATGTGAC	0.353		NA											17	106					0	0	0	0
FAT1	2195	broad.mit.edu	37	4	187532590	187532590	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr4:187532590G>C	uc003izf.2	-	14	9991	c.9803C>G	c.(9802-9804)TCA>TGA	p.S3268*		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	3268	Extracellular (Potential).|Cadherin 30.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						ACTTATTATTGAGTAGGTGAT	0.403		NA								HNSCC(5;0.00058)			7	27					0	0	0	0
FAT1	2195	broad.mit.edu	37	4	187539227	187539227	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr4:187539227G>C	uc003izf.2	-	10	8701	c.8513C>G	c.(8512-8514)TCA>TGA	p.S2838*		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	2838	Extracellular (Potential).|Cadherin 26.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GTTGGTTCCTGAGTCAGCATC	0.448		NA								HNSCC(5;0.00058)			15	106					0	0	0	0
FAT1	2195	broad.mit.edu	37	4	187629184	187629184	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr4:187629184G>A	uc003izf.2	-	2	1986	c.1798C>T	c.(1798-1800)CAG>TAG	p.Q600*	FAT1_uc010iso.1_Nonsense_Mutation_p.Q600*	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	600	Extracellular (Potential).|Cadherin 5.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						TGTACCAACTGAAGTTCATCT	0.408		NA								HNSCC(5;0.00058)			6	41					0	0	0	0
DNAH5	1767	broad.mit.edu	37	5	13841896	13841896	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr5:13841896G>C	uc003jfd.2	-	33	5431	c.5389C>G	c.(5389-5391)CAG>GAG	p.Q1797E		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1797	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					AATGAGGACTGAGATTCTTCC	0.438		NA							Kartagener_syndrome				7	50					0	0	0	0
DNAH5	1767	broad.mit.edu	37	5	13883188	13883188	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr5:13883188G>A	uc003jfd.2	-	20	3041	c.2999C>T	c.(2998-3000)TCT>TTT	p.S1000F		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1000	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CTTCATGTTAGAGGCACTGTT	0.378		NA							Kartagener_syndrome				13	92					0	0	0	0
LMBRD2	92255	broad.mit.edu	37	5	36122518	36122518	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr5:36122518C>A	uc003jkb.1	-	9	1399	c.984G>T	c.(982-984)CAG>CAT	p.Q328H		NM_001007527	NP_001007528	Q68DH5	LMBD2_HUMAN	LMBR1 domain containing 2	328	Cytoplasmic (Potential).					integral to membrane					0	all_lung(31;0.000146)		Epithelial(62;0.0396)|Lung(74;0.111)|all cancers(62;0.115)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CCAAAAGAATCTGCCATTGTA	0.408		NA											4	40					0.00909568	0.00940813	1	0
TTC33	23548	broad.mit.edu	37	5	40747077	40747077	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr5:40747077G>C	uc003jma.2	-	2	192	c.44C>G	c.(43-45)TCA>TGA	p.S15*	TTC33_uc011cpm.1_5'UTR|TTC33_uc010ivg.2_Nonsense_Mutation_p.S15*	NM_012382	NP_036514	Q6PID6	TTC33_HUMAN	tetratricopeptide repeat domain 33	15							binding			ovary(1)	1						AGTGACCTTTGAGACCTTCTC	0.388		NA											6	46					0	0	0	0
C6	729	broad.mit.edu	37	5	41203191	41203191	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr5:41203191T>C	uc003jmk.2	-	2	352	c.142A>G	c.(142-144)AGA>GGA	p.R48G	C6_uc003jml.1_Missense_Mutation_p.R48G	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	48	TSP type-1 1.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				CACACCCACCTGTGTCTGCTC	0.478		NA											6	238					0	0	0	0
BTF3	689	broad.mit.edu	37	5	72798854	72798854	+	Silent	SNP	G	G	C			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr5:72798854G>C	uc003kcr.1	+	4	672	c.429G>C	c.(427-429)CTG>CTC	p.L143L	BTF3_uc003kcq.1_Silent_p.L99L|BTF3_uc003kcs.1_RNA|BTF3_uc003kct.1_RNA	NM_001037637	NP_001032726	P20290	BTF3_HUMAN	basic transcription factor 3 isoform A	143	NAC-A/B.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding				0		Lung NSC(167;0.00405)|Ovarian(174;0.0175)		OV - Ovarian serous cystadenocarcinoma(47;2.73e-54)		CAAAGCAGCTGACAGAAATGC	0.473		NA											15	86					0	0	0	0
REEP5	7905	broad.mit.edu	37	5	112256898	112256898	+	Silent	SNP	G	G	C			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr5:112256898G>C	uc003kqe.1	-	2	318	c.174C>G	c.(172-174)CTC>CTG	p.L58L	REEP5_uc011cvw.1_Silent_p.L31L|REEP5_uc011cvx.1_RNA|REEP5_uc011cvy.1_Silent_p.L58L|REEP5_uc011cvz.1_RNA	NM_005669	NP_005660	Q00765	REEP5_HUMAN	receptor accessory protein 5	58						integral to membrane	protein binding				0		all_cancers(142;4.41e-05)|all_epithelial(76;3.65e-07)|Colorectal(10;0.00115)|Prostate(80;0.00133)|Ovarian(225;0.0443)		Epithelial(69;1.3e-09)|OV - Ovarian serous cystadenocarcinoma(64;1.26e-08)|all cancers(49;3.56e-07)|Colorectal(14;0.00778)|COAD - Colon adenocarcinoma(37;0.013)		TCAGGTTGCAGAGGAGAGAGG	0.597		NA											7	43					0	0	0	0
HSD17B4	3295	broad.mit.edu	37	5	118832266	118832266	+	Silent	SNP	G	G	C			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr5:118832266G>C	uc003ksj.2	+	12	1020	c.897G>C	c.(895-897)CTG>CTC	p.L299L	HSD17B4_uc011cwg.1_Silent_p.L275L|HSD17B4_uc011cwh.1_Silent_p.L281L|HSD17B4_uc011cwi.1_Silent_p.L324L|HSD17B4_uc003ksk.3_Silent_p.L152L|HSD17B4_uc011cwj.1_Silent_p.L152L|HSD17B4_uc010jcn.1_Silent_p.L37L	NM_000414	NP_000405	P51659	DHB4_HUMAN	hydroxysteroid (17-beta) dehydrogenase 4	299	(3R)-hydroxyacyl-CoA dehydrogenase.				bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	3-hydroxyacyl-CoA dehydrogenase activity|3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity|estradiol 17-beta-dehydrogenase activity|isomerase activity|long-chain-enoyl-CoA hydratase activity|protein binding|sterol binding|sterol transporter activity			ovary(1)|pancreas(1)	2		all_cancers(142;0.0206)|Prostate(80;0.0322)		OV - Ovarian serous cystadenocarcinoma(64;0.000247)|Epithelial(69;0.000849)|all cancers(49;0.0122)	NADH(DB00157)	TTGAAGTTCTGAGTAAAATAG	0.333		NA											8	115					0	0	0	0
RAD50	10111	broad.mit.edu	37	5	131930643	131930643	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr5:131930643G>A	uc003kxi.2	+	12	2263	c.1876G>A	c.(1876-1878)GAA>AAA	p.E626K	RAD50_uc003kxh.2_Missense_Mutation_p.E487K	NM_005732	NP_005723	Q92878	RAD50_HUMAN	RAD50 homolog isoform 1	626					DNA duplex unwinding|double-strand break repair via homologous recombination|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|telomere maintenance via telomerase	Mre11 complex|nuclear chromosome, telomeric region|nucleoplasm	ATP binding|DNA binding|nuclease activity|protein binding, bridging|zinc ion binding			lung(2)|ovary(1)|skin(1)	4		all_cancers(142;0.0368)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GTCCAGTTACGAAGACAAGCT	0.338		NA						Homologous_recombination					12	63					0	0	0	0
PCDHA2	56146	broad.mit.edu	37	5	140176795	140176795	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr5:140176795C>T	uc003lhd.2	+	1	2352	c.2246C>T	c.(2245-2247)TCT>TTT	p.S749F	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhc.1_Missense_Mutation_p.S749F|PCDHA2_uc011czy.1_Missense_Mutation_p.S749F	NM_018905	NP_061728	Q9Y5H9	PCDA2_HUMAN	protocadherin alpha 2 isoform 1 precursor	749	Cytoplasmic (Potential).|5 X 4 AA repeats of P-X-X-P.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGAGCTGGTCTTACTCGCAG	0.672		NA											19	77					0	0	0	0
PCDHA13	56136	broad.mit.edu	37	5	140263342	140263342	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr5:140263342C>T	uc003lif.2	+	1	1489	c.1489C>T	c.(1489-1491)CGG>TGG	p.R497W	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Missense_Mutation_p.R497W|PCDHA13_uc003lid.2_Missense_Mutation_p.R497W	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	497	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTGGTGGAGCGGCGGGTGGG	0.662		NA											12	85					0	0	0	0
PCDHGB2	56103	broad.mit.edu	37	5	140741419	140741419	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr5:140741419G>A	uc003ljs.1	+	1	1717	c.1717G>A	c.(1717-1719)GCC>ACC	p.A573T	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGA5_uc003lju.1_5'Flank|PCDHGB2_uc011dar.1_Missense_Mutation_p.A573T|PCDHGA5_uc011das.1_5'Flank	NM_018923	NP_061746	Q9Y5G2	PCDGE_HUMAN	protocadherin gamma subfamily B, 2 isoform 1	573	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGATGGCTCCGCCCTCTTCGA	0.667		NA											12	54					0	0	0	0
PCDHGB5	56101	broad.mit.edu	37	5	140779485	140779485	+	Silent	SNP	C	C	T			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr5:140779485C>T	uc003lkf.1	+	1	1791	c.1791C>T	c.(1789-1791)AAC>AAT	p.N597N	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc011daw.1_Silent_p.N597N	NM_018925	NP_061748	Q9Y5G0	PCDGH_HUMAN	protocadherin gamma subfamily B, 5 isoform 1	597	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGGACACAACGCCTGGCTGT	0.677		NA											12	71					0	0	0	0
RELL2	285613	broad.mit.edu	37	5	141019745	141019745	+	Silent	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr5:141019745G>A	uc003lli.2	+	6	1610	c.762G>A	c.(760-762)GGG>GGA	p.G254G	RELL2_uc003llh.2_Silent_p.G254G|RELL2_uc003llg.2_Silent_p.G188G|RELL2_uc010jgf.2_Silent_p.G188G|FCHSD1_uc010jgg.2_3'UTR|FCHSD1_uc003llj.2_RNA|FCHSD1_uc003llk.2_3'UTR	NM_001130029	NP_001123501	Q8NC24	RELL2_HUMAN	RELT-like 2	254						integral to membrane|plasma membrane					0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACTTGAAGGGAACCCCAGAG	0.647		NA											4	58					0	0	0	0
STK32A	202374	broad.mit.edu	37	5	146750271	146750271	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr5:146750271G>C	uc010jgn.1	+	9	995	c.715G>C	c.(715-717)GAG>CAG	p.E239Q	STK32A_uc003lom.2_Missense_Mutation_p.E239Q|STK32A_uc011dbw.1_Missense_Mutation_p.E239Q	NM_001112724	NP_001106195	Q8WU08	ST32A_HUMAN	serine/threonine kinase 32A isoform 1	239	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(2)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACACACGTTTGAGACGACTGT	0.398		NA											9	131					0	0	0	0
GCNT2	2651	broad.mit.edu	37	6	10529667	10529667	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr6:10529667G>A	uc010joo.2	+	3	1074	c.523G>A	c.(523-525)GAA>AAA	p.E175K	GCNT2_uc010jol.2_Intron|GCNT2_uc010jom.2_Intron|GCNT2_uc010jop.2_Intron|GCNT2_uc003mza.2_Intron|GCNT2_uc003mzc.3_Missense_Mutation_p.E174K|GCNT2_uc010jon.2_Missense_Mutation_p.E174K	NM_145649	NP_663624	Q8N0V5	GNT2A_HUMAN	glucosaminyl (N-acetyl) transferase 2,	175	Lumenal (Potential).					Golgi membrane|integral to membrane	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			ovary(2)	2	Ovarian(93;0.107)|Breast(50;0.148)	all_hematologic(90;0.107)		KIRC - Kidney renal clear cell carcinoma(1;0.099)|Kidney(1;0.119)		GAACTGCCTGGAAGACCTTGT	0.507		NA											21	39					0	0	0	0
OR2J3	442186	broad.mit.edu	37	6	29079743	29079743	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr6:29079743C>G	uc011dll.1	+	1	76	c.76C>G	c.(76-78)CTG>GTG	p.L26V		NM_001005216	NP_001005216	O76001	OR2J3_HUMAN	olfactory receptor, family 2, subfamily J,	26	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TTGGCCTCATCTGGAAGTAGT	0.383		NA											33	109					0	0	0	0
MDC1	9656	broad.mit.edu	37	6	30671732	30671732	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr6:30671732G>C	uc003nrg.3	-	10	5668	c.5228C>G	c.(5227-5229)TCT>TGT	p.S1743C	MDC1_uc003nrf.3_Intron|MDC1_uc011dmp.1_Missense_Mutation_p.S1350C	NM_014641	NP_055456	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	1743	Required for nuclear localization (NLS2).				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|ovary(1)|kidney(1)	4						CAAGGGTGCAGAGCAAGGCTT	0.562		NA						Other_conserved_DNA_damage_response_genes					19	66					0	0	0	0
PSORS1C2	170680	broad.mit.edu	37	6	31106763	31106763	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr6:31106763C>A	uc003nso.3	-	1	365	c.41G>T	c.(40-42)TGC>TTC	p.C14F	PSORS1C1_uc003nsl.1_Intron|PSORS1C1_uc010jsj.1_Intron|PSORS1C1_uc003nsn.1_Intron	NM_014069	NP_054788	Q9UIG4	PS1C2_HUMAN	SPR1 protein precursor	14						extracellular region					0						GGTGTGCAGGCAAAGGACCAG	0.597		NA											10	51					0.00829132	0.00862552	1	0
DST	667	broad.mit.edu	37	6	56374648	56374648	+	Silent	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr6:56374648G>A	uc003pdf.2	-	68	12475	c.12447C>T	c.(12445-12447)ATC>ATT	p.I4149I	DST_uc003pcz.3_Silent_p.I3971I|DST_uc011dxj.1_Silent_p.I4000I|DST_uc011dxk.1_Silent_p.I4011I|DST_uc003pcy.3_Silent_p.I3645I	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	6057	Spectrin 12.				cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			GGCTCTCAAGGATCTGATCTA	0.398		NA											5	45					0	0	0	0
DOPEY1	23033	broad.mit.edu	37	6	83810518	83810518	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr6:83810518G>C	uc003pjs.1	+	4	493	c.233G>C	c.(232-234)GGA>GCA	p.G78A	DOPEY1_uc011dyy.1_Missense_Mutation_p.G78A|DOPEY1_uc010kbl.1_Missense_Mutation_p.G78A	NM_015018	NP_055833	Q5JWR5	DOP1_HUMAN	dopey family member 1	78					protein transport					ovary(2)|breast(1)|central_nervous_system(1)	4		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		TTACCAGGTGGAGTTCATCGG	0.363		NA											26	181					0	0	0	0
RARS2	57038	broad.mit.edu	37	6	88251661	88251661	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr6:88251661G>C	uc003pme.2	-	8	647	c.587C>G	c.(586-588)TCC>TGC	p.S196C	RARS2_uc003pmb.2_Missense_Mutation_p.S21C|RARS2_uc003pmc.2_Missense_Mutation_p.S21C|RARS2_uc003pmd.2_5'UTR|RARS2_uc003pmf.2_RNA	NM_020320	NP_064716	Q5T160	SYRM_HUMAN	arginyl-tRNA synthetase 2, mitochondrial	196					arginyl-tRNA aminoacylation	mitochondrial matrix	arginine-tRNA ligase activity|ATP binding|protein binding			ovary(2)|central_nervous_system(1)	3		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0456)		TAGAGGATTGGACTGCAGTTT	0.363		NA											4	26					0	0	0	0
REV3L	5980	broad.mit.edu	37	6	111696128	111696128	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr6:111696128C>T	uc003puy.3	-	13	3753	c.3430G>A	c.(3430-3432)GAA>AAA	p.E1144K	REV3L_uc003pux.3_Missense_Mutation_p.E1066K|REV3L_uc003puz.3_Missense_Mutation_p.E1066K	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta	1144					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		GCCTCTTTTTCTGCAGCAGCC	0.418		NA						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					15	117					0	0	0	0
LAMA2	3908	broad.mit.edu	37	6	129714246	129714246	+	Missense_Mutation	SNP	A	A	G	rs141950826		TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr6:129714246A>G	uc003qbn.2	+	37	5396	c.5291A>G	c.(5290-5292)GAA>GGA	p.E1764G	LAMA2_uc003qbo.2_Missense_Mutation_p.E1764G	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1764	Domain II and I.|Potential.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		TCCCGGGGGGAAAATGAAGAA	0.453		NA											3	73					0	0	0	0
SYNE1	23345	broad.mit.edu	37	6	152557387	152557387	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr6:152557387C>G	uc010kiw.2	-	110	20853	c.20251G>C	c.(20251-20253)GAT>CAT	p.D6751H	SYNE1_uc010kiv.2_Missense_Mutation_p.D1275H|SYNE1_uc003qos.3_Missense_Mutation_p.D1275H|SYNE1_uc003qot.3_Missense_Mutation_p.D6680H|SYNE1_uc003qou.3_Missense_Mutation_p.D6751H	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	6751	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TTCCCATCATCTAATACTTGA	0.328		NA								HNSCC(10;0.0054)			5	50					0	0	0	0
CCR6	1235	broad.mit.edu	37	6	167550802	167550802	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr6:167550802G>A	uc003qvl.2	+	13	3560	c.1084G>A	c.(1084-1086)GAG>AAG	p.E362K	CCR6_uc010kkm.2_Missense_Mutation_p.E362K|CCR6_uc003qvn.3_Missense_Mutation_p.E362K|CCR6_uc003qvm.3_Missense_Mutation_p.E362K	NM_031409	NP_113597	P51684	CCR6_HUMAN	chemokine (C-C motif) receptor 6	362	Cytoplasmic (Potential).				cellular defense response|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|humoral immune response	integral to plasma membrane	C-C chemokine receptor activity			ovary(1)	1		Breast(66;1.53e-05)|Ovarian(120;0.0606)		OV - Ovarian serous cystadenocarcinoma(33;8.21e-20)|BRCA - Breast invasive adenocarcinoma(81;4.55e-06)|GBM - Glioblastoma multiforme(31;0.00507)		GCAGACCAGTGAGACCGCAGA	0.438		NA											5	52					0	0	0	0
CCDC129	223075	broad.mit.edu	37	7	31683300	31683300	+	Silent	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr7:31683300G>A	uc003tcj.1	+	11	3309	c.2316G>A	c.(2314-2316)TTG>TTA	p.L772L	CCDC129_uc011kad.1_Silent_p.L782L|CCDC129_uc003tci.1_Silent_p.L623L|CCDC129_uc011kae.1_Silent_p.L798L|CCDC129_uc003tck.1_Silent_p.L680L	NM_194300	NP_919276	Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	772											0						ACAAGACCTTGACACATGGGC	0.502		NA											17	79					0	0	0	0
HECW1	23072	broad.mit.edu	37	7	43531746	43531746	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr7:43531746C>G	uc003tid.1	+	18	3912	c.3307C>G	c.(3307-3309)CGA>GGA	p.R1103G	HECW1_uc011kbi.1_Missense_Mutation_p.R1069G	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	1103					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity	p.R1103H(1)		ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						AGCTGCTATTCGAAGCCAACA	0.423		NA											9	73					0	0	0	0
C7orf57	136288	broad.mit.edu	37	7	48092304	48092304	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr7:48092304C>G	uc003toh.3	+	7	825	c.613C>G	c.(613-615)CAA>GAA	p.Q205E	C7orf57_uc003toi.3_Intron	NM_001100159	NP_001093629	Q8NEG2	CG057_HUMAN	hypothetical protein LOC136288	205										ovary(1)	1						AAGGCCTGGTCAAAAAAACAG	0.408		NA											5	99					0	0	0	0
FIGNL1	63979	broad.mit.edu	37	7	50513306	50513306	+	Silent	SNP	C	C	T	rs143012740		TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr7:50513306C>T	uc003tpc.2	-	4	2057	c.1680G>A	c.(1678-1680)GTG>GTA	p.V560V	FIGNL1_uc003tpb.2_Silent_p.V449V|FIGNL1_uc003tpd.2_Silent_p.V560V|FIGNL1_uc003tpe.2_Silent_p.V560V|FIGNL1_uc010kyy.2_Silent_p.V560V	NM_001042762	NP_001036227	Q6PIW4	FIGL1_HUMAN	fidgetin-like 1	560					ATP metabolic process|negative regulation of apoptosis|osteoblast differentiation|osteoblast proliferation|regulation of cell cycle	cytoplasm|nucleus	ATP binding|magnesium ion binding|nucleoside-triphosphatase activity			ovary(3)	3	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;3.73e-08)|all_hematologic(4;7.51e-06)				AAAGCCTTTTCACCAATCTTC	0.433		NA											4	92					0	0	0	0
CCDC146	57639	broad.mit.edu	37	7	76924175	76924175	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr7:76924175G>C	uc003uga.2	+	19	2987	c.2860G>C	c.(2860-2862)GAA>CAA	p.E954Q	CCDC146_uc010ldp.2_Missense_Mutation_p.E668Q|CCDC146_uc003ugc.2_Missense_Mutation_p.E291Q	NM_020879	NP_065930	Q8IYE0	CC146_HUMAN	coiled-coil domain containing 146	954										ovary(1)|central_nervous_system(1)	2		all_cancers(73;0.128)|all_lung(88;0.0986)|all_epithelial(88;0.163)|Myeloproliferative disorder(862;0.205)				AAAGCCAGTTGAAATCTGAAT	0.413		NA											4	27					0	0	0	0
GRM3	2913	broad.mit.edu	37	7	86468876	86468876	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr7:86468876C>A	uc003uid.2	+	4	3145	c.2046C>A	c.(2044-2046)TTC>TTA	p.F682L	GRM3_uc010lef.2_Intron|GRM3_uc010leg.2_Missense_Mutation_p.F554L|GRM3_uc010leh.2_Missense_Mutation_p.F274L	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	682	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	GGCCAAAATTCATCAGCCCCA	0.542		NA											18	71					2.35e-11	2.61e-11	1	0
C7orf63	79846	broad.mit.edu	37	7	89939442	89939442	+	Silent	SNP	C	C	T			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr7:89939442C>T	uc010lep.2	+	23	2967	c.2716C>T	c.(2716-2718)CTG>TTG	p.L906L	C7orf63_uc011khj.1_Silent_p.L888L|C7orf63_uc011khk.1_Silent_p.L422L	NM_001039706	NP_001034795	A5D8W1	CG063_HUMAN	hypothetical protein LOC79846 isoform 1	906							binding			ovary(1)	1						AGGAGGACCTCTGGTTGATAC	0.433		NA											6	74					0	0	0	0
HBP1	26959	broad.mit.edu	37	7	106826264	106826264	+	Silent	SNP	C	C	T			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr7:106826264C>T	uc003vdy.2	+	4	603	c.417C>T	c.(415-417)ATC>ATT	p.I139I	HBP1_uc011klv.1_Silent_p.I149I|HBP1_uc003vdz.2_Silent_p.I139I|HBP1_uc003vea.2_Silent_p.I139I|HBP1_uc003veb.1_Silent_p.I139I	NM_012257	NP_036389	O60381	HBP1_HUMAN	HMG-box transcription factor 1	139					cell cycle arrest|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	DNA binding			skin(1)	1						CTGTACACATCATAGCCACTA	0.403		NA											18	133					0	0	0	0
RBM28	55131	broad.mit.edu	37	7	127961459	127961459	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr7:127961459G>C	uc003vmp.2	-	14	1538	c.1423C>G	c.(1423-1425)CAG>GAG	p.Q475E	RBM28_uc003vmo.2_Missense_Mutation_p.Q92E|RBM28_uc011koj.1_Missense_Mutation_p.Q334E	NM_018077	NP_060547	Q9NW13	RBM28_HUMAN	RNA binding motif protein 28	475					mRNA processing|RNA splicing	Golgi apparatus|nucleolus|spliceosomal complex	nucleotide binding|RNA binding			ovary(2)	2						TTGAGTTTCTGATGCTTCAGC	0.433		NA											6	47					0	0	0	0
CNTNAP2	26047	broad.mit.edu	37	7	146536831	146536831	+	Silent	SNP	C	C	T	rs145162968		TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr7:146536831C>T	uc003weu.1	+	3	753	c.237C>T	c.(235-237)AGC>AGT	p.S79S		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	79	F5/8 type C.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			CATCAGACAGCGACCATTATC	0.448		NA								HNSCC(39;0.1)			11	54					0	0	0	0
CNTNAP2	26047	broad.mit.edu	37	7	147869376	147869376	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr7:147869376C>T	uc003weu.1	+	18	3332	c.2816C>T	c.(2815-2817)TCC>TTC	p.S939F		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	939	Laminin G-like 3.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			TGCATCCGCTCCTTGAGGATG	0.542		NA								HNSCC(39;0.1)			10	65					0	0	0	0
PIWIL2	55124	broad.mit.edu	37	8	22167484	22167484	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr8:22167484G>A	uc003xbn.2	+	15	1845	c.1697G>A	c.(1696-1698)CGT>CAT	p.R566H	PIWIL2_uc011kzf.1_Missense_Mutation_p.R566H|PIWIL2_uc010ltv.2_Missense_Mutation_p.R566H	NM_018068	NP_060538	Q8TC59	PIWL2_HUMAN	piwi-like 2	566					DNA methylation involved in gamete generation|gene silencing by RNA|germ-line stem cell maintenance|multicellular organismal development|oogenesis|piRNA metabolic process|positive regulation of translation|RNA 5'-end processing|spermatogenesis	chromatoid body|pi-body	piRNA binding			skin(1)	1				Colorectal(74;0.018)|COAD - Colon adenocarcinoma(73;0.0707)		ATTGAAGGACGTGTTCTGCCA	0.383		NA											6	49					0	0	0	0
PLAT	5327	broad.mit.edu	37	8	42038171	42038171	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr8:42038171G>A	uc003xos.2	-	10	1131	c.922C>T	c.(922-924)CAG>TAG	p.Q308*	PLAT_uc010lxf.1_Nonsense_Mutation_p.Q225*|PLAT_uc010lxg.1_Nonsense_Mutation_p.Q133*|PLAT_uc003xot.2_Nonsense_Mutation_p.Q262*|PLAT_uc011lcm.1_Nonsense_Mutation_p.Q219*|PLAT_uc011lcn.1_Nonsense_Mutation_p.Q182*	NM_000930	NP_000921	P00750	TPA_HUMAN	plasminogen activator, tissue isoform 1	308					blood coagulation|fibrinolysis|negative regulation of proteolysis|protein modification process|proteolysis	cell surface|cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			breast(1)|skin(1)	2	all_cancers(6;3.84e-26)|all_epithelial(6;9.61e-28)|all_lung(13;7.2e-13)|Lung NSC(13;1.18e-11)|Ovarian(28;0.00438)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000378)|Lung NSC(58;0.00145)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;5.23e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00135)|Colorectal(10;0.00165)|Lung(22;0.00467)|COAD - Colon adenocarcinoma(11;0.0171)|LUSC - Lung squamous cell carcinoma(45;0.024)		Alteplase(DB00009)|Aminocaproic Acid(DB00513)|Anistreplase(DB00029)|Iloprost(DB01088)|Reteplase(DB00015)|Tenecteplase(DB00031)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	ATGCGAAACTGAGGCTGGCTG	0.632		NA											8	35					0	0	0	0
PRKDC	5591	broad.mit.edu	37	8	48842538	48842538	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr8:48842538C>A	uc003xqi.2	-	18	1984	c.1927G>T	c.(1927-1929)GAA>TAA	p.E643*	PRKDC_uc003xqj.2_Nonsense_Mutation_p.E643*|PRKDC_uc011ldh.1_Nonsense_Mutation_p.E643*	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	643					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				ACCCATGGTTCAAAAAATTCT	0.318		NA						NHEJ					5	80					5.94e-07	6.49e-07	1	0
RGS20	8601	broad.mit.edu	37	8	54866838	54866838	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr8:54866838G>A	uc003xrp.2	+	5	1038	c.946G>A	c.(946-948)GAA>AAA	p.E316K	RGS20_uc003xrq.2_Missense_Mutation_p.E201K|RGS20_uc010lye.2_Missense_Mutation_p.E108K|RGS20_uc010lyf.2_Missense_Mutation_p.E80K|RGS20_uc003xrs.2_Missense_Mutation_p.E169K|RGS20_uc003xrt.2_Missense_Mutation_p.E50K	NM_170587	NP_733466	O76081	RGS20_HUMAN	regulator of G-protein signaling 20 isoform a	316	RGS.				negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|nucleus|plasma membrane	GTPase activator activity|protein binding|signal transducer activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(7;1.37e-06)|Epithelial(17;0.000126)|all cancers(17;0.0009)			GATAATCTATGAAGACTACAT	0.378		NA											6	47					0	0	0	0
RUNX1T1	862	broad.mit.edu	37	8	92972554	92972554	+	Silent	SNP	C	C	T			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr8:92972554C>T	uc003yfd.2	-	11	1815	c.1731G>A	c.(1729-1731)GGG>GGA	p.G577G	RUNX1T1_uc003yfc.1_Silent_p.G550G|RUNX1T1_uc003yfe.1_Silent_p.G540G|RUNX1T1_uc010mao.2_Silent_p.G550G|RUNX1T1_uc011lgi.1_Silent_p.G588G|uc010mam.2_5'Flank|RUNX1T1_uc010man.1_Silent_p.G202G|RUNX1T1_uc003yfb.1_Silent_p.G540G	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	577					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			CCATCGGGCTCCCAGCCCCGC	0.622		NA											8	39					0	0	0	0
HAS2	3037	broad.mit.edu	37	8	122626424	122626424	+	Silent	SNP	C	C	T			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr8:122626424C>T	uc003yph.2	-	4	2122	c.1584G>A	c.(1582-1584)ACG>ACA	p.T528T		NM_005328	NP_005319	Q92819	HAS2_HUMAN	hyaluronan synthase 2	528	Helical; Name=7; (Potential).					integral to plasma membrane	hyaluronan synthase activity		HAS2/PLAG1(10)	soft_tissue(10)|ovary(5)	15	Lung NSC(37;3.12e-08)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)|all_neural(195;0.142)		STAD - Stomach adenocarcinoma(47;0.00503)			CTACATACAGCGTCAAAAGCA	0.408		NA											14	84					0	0	0	0
PUF60	22827	broad.mit.edu	37	8	144899260	144899260	+	Silent	SNP	C	C	T			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr8:144899260C>T	uc003yzs.2	-	11	1264	c.1200G>A	c.(1198-1200)GTG>GTA	p.V400V	SCRIB_uc003yzo.1_5'Flank|SCRIB_uc003yzp.1_5'Flank|PUF60_uc003yzr.2_Silent_p.V340V|PUF60_uc003yzt.2_Silent_p.V383V|PUF60_uc003yzq.2_Silent_p.V357V|PUF60_uc003yzu.1_Silent_p.V389V	NM_078480	NP_510965	Q9UHX1	PUF60_HUMAN	poly-U binding splicing factor 60KDa isoform a	400	Inhibits homodimerization.|Inhibits transcriptional repression, interaction with ERCC3 and apoptosis induction.				apoptosis|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	nucleus|ribonucleoprotein complex	DNA binding|nucleotide binding|protein binding|RNA binding				0	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;6.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			GGATGGGGTTCACCACTCCCA	0.622		NA											3	25					0	0	0	0
KIAA2026	158358	broad.mit.edu	37	9	5921788	5921788	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr9:5921788G>C	uc003zjq.3	-	8	4424	c.4208C>G	c.(4207-4209)TCT>TGT	p.S1403C	KIAA2026_uc010mht.2_Missense_Mutation_p.S578C	NM_001017969	NP_001017969	Q5HYC2	K2026_HUMAN	hypothetical protein LOC158358	1403	Ser-rich.									ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		TAGAGTACTAGAACAAATAGA	0.393		NA											15	92					0	0	0	0
CDKN2A	1029	broad.mit.edu	37	9	21971028	21971028	+	Nonsense_Mutation	SNP	C	C	T	rs121913389		TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr9:21971028C>T	uc003zpk.2	-	2	542	c.330G>A	c.(328-330)TGG>TGA	p.W110*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.G166R	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	110	ANK 4.				cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.W110*(38)|p.?(13)|p.H83fs*2(2)|p.W110fs*9(1)|p.D105fs*8(1)|p.A68fs*3(1)|p.R107fs*33(1)|p.W110fs*36(1)|p.W110C(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		GCAGACGGCCCCAGGCATCGC	0.736		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			10	23					0	0	0	0
TLN1	7094	broad.mit.edu	37	9	35698089	35698089	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr9:35698089C>G	uc003zxt.2	-	56	7806	c.7452G>C	c.(7450-7452)GAG>GAC	p.E2484D		NM_006289	NP_006280	Q9Y490	TLN1_HUMAN	talin 1	2484	I/LWEQ.				axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			lung(7)|breast(3)|ovary(2)|central_nervous_system(1)	13	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			CTGTCTCATTCTCCTGCTCTT	0.562		NA											15	93					0	0	0	0
KIAA1958	158405	broad.mit.edu	37	9	115422154	115422154	+	Silent	SNP	C	C	T			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr9:115422154C>T	uc004bgf.1	+	4	2131	c.1956C>T	c.(1954-1956)TTC>TTT	p.F652F	KIAA1958_uc011lwx.1_Silent_p.F680F	NM_133465	NP_597722	Q8N8K9	K1958_HUMAN	hypothetical protein LOC158405	652										skin(1)	1						AGTCCCCCTTCTACCTGACTG	0.577		NA											6	35					0	0	0	0
LCN6	158062	broad.mit.edu	37	9	139639631	139639631	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr9:139639631C>T	uc004ciy.2	-	4	448	c.403G>A	c.(403-405)GAG>AAG	p.E135K	LCN10_uc004civ.2_5'Flank|LCN10_uc011med.1_5'Flank|LCN10_uc010nbq.2_5'Flank|LCN10_uc011mee.1_5'Flank|LCN10_uc011mef.1_5'Flank|LCN10_uc004ciw.2_RNA|uc004ciz.1_5'Flank	NM_198946	NP_945184	P62502	LCN6_HUMAN	lipocalin 6 precursor	135					single fertilization	extracellular region	binding				0	all_cancers(76;0.0882)|all_epithelial(76;0.228)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.32e-06)|Epithelial(140;7.83e-05)		CTGTACAGCTCCACGGTGTTG	0.627		NA											10	51					0	0	0	0
DCAF8L1	139425	broad.mit.edu	37	X	27999311	27999311	+	Silent	SNP	C	C	G			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chrX:27999311C>G	uc004dbx.1	-	1	256	c.141G>C	c.(139-141)TCG>TCC	p.S47S		NM_001017930	NP_001017930	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	47										ovary(3)|skin(1)	4						CATCTCCGGTCGATGGCTCTG	0.532		NA											9	28					0	0	0	0
XK	7504	broad.mit.edu	37	X	37587032	37587032	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chrX:37587032G>C	uc004ddq.2	+	3	734	c.652G>C	c.(652-654)GAG>CAG	p.E218Q		NM_021083	NP_066569	P51811	XK_HUMAN	membrane transport protein XK	218	Helical; (Potential).				amino acid transport	integral to membrane	protein binding|transporter activity				0		all_lung(315;0.175)				GAGGAGCTTTGAGATTGCCAC	0.458		NA											8	17					0	0	0	0
SHROOM4	57477	broad.mit.edu	37	X	50377069	50377069	+	Silent	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chrX:50377069G>A	uc004dpe.2	-	4	2030	c.2004C>T	c.(2002-2004)CTC>CTT	p.L668L	SHROOM4_uc004dpd.3_RNA|SHROOM4_uc004dpf.1_Silent_p.L552L	NM_020717	NP_065768	Q9ULL8	SHRM4_HUMAN	shroom family member 4	668					actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding			upper_aerodigestive_tract(1)	1	Ovarian(276;0.236)					GGGCTTGGCTGAGGCACTCGG	0.527		NA											7	15					0	0	0	0
SHROOM4	57477	broad.mit.edu	37	X	50377082	50377082	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chrX:50377082G>A	uc004dpe.2	-	4	2017	c.1991C>T	c.(1990-1992)TCT>TTT	p.S664F	SHROOM4_uc004dpd.3_RNA|SHROOM4_uc004dpf.1_Missense_Mutation_p.S548F	NM_020717	NP_065768	Q9ULL8	SHRM4_HUMAN	shroom family member 4	664					actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding			upper_aerodigestive_tract(1)	1	Ovarian(276;0.236)					GCACTCGGAAGACCTAGCTCT	0.532		NA											9	17					0	0	0	0
SHROOM4	57477	broad.mit.edu	37	X	50377856	50377856	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chrX:50377856G>C	uc004dpe.2	-	4	1243	c.1217C>G	c.(1216-1218)ACA>AGA	p.T406R	SHROOM4_uc004dpd.3_RNA|SHROOM4_uc004dpf.1_Missense_Mutation_p.T290R	NM_020717	NP_065768	Q9ULL8	SHRM4_HUMAN	shroom family member 4	406					actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding			upper_aerodigestive_tract(1)	1	Ovarian(276;0.236)					GCGATGCCCTGTGGGTCCTAT	0.567		NA											5	11					0	0	0	0
ATP7A	538	broad.mit.edu	37	X	77243873	77243873	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chrX:77243873G>A	uc004ecx.3	+	3	416	c.256G>A	c.(256-258)GAC>AAC	p.D86N	ATP7A_uc004ecw.2_Missense_Mutation_p.D86N	NM_000052	NP_000043	Q04656	ATP7A_HUMAN	ATPase, Cu++ transporting, alpha polypeptide	86	Cytoplasmic (Potential).				ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity				0						TGTTTTAACTGACACCTTGTT	0.443		NA											72	166					0	0	0	0
MID2	11043	broad.mit.edu	37	X	107169397	107169397	+	Silent	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chrX:107169397G>A	uc004enl.2	+	9	2244	c.1671G>A	c.(1669-1671)GAG>GAA	p.E557E	MID2_uc004enk.2_Silent_p.E527E	NM_012216	NP_036348	Q9UJV3	TRIM1_HUMAN	midline 2 isoform 1	557	B30.2/SPRY.					centrosome|microtubule	ligase activity|zinc ion binding			ovary(1)	1						TGCAGATGGAGAAGGATGAAA	0.423		NA											19	51					0	0	0	0
AFF2	2334	broad.mit.edu	37	X	148059934	148059934	+	Silent	SNP	G	G	A			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chrX:148059934G>A	uc004fcp.2	+	18	3998	c.3519G>A	c.(3517-3519)CTG>CTA	p.L1173L	AFF2_uc004fcq.2_Silent_p.L1163L|AFF2_uc004fcr.2_Silent_p.L1134L|AFF2_uc011mxb.1_Silent_p.L1138L|AFF2_uc004fcs.2_Silent_p.L1138L|AFF2_uc011mxc.1_Silent_p.L814L	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	1173					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					TGTTTAAGCTGAAGAAGGACC	0.348		NA											10	43					0	0	0	0
FAM3A	60343	broad.mit.edu	37	X	153735753	153735753	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chrX:153735753C>T	uc004fls.1	-	7	731	c.454G>A	c.(454-456)GAC>AAC	p.D152N	FAM3A_uc004flt.1_Missense_Mutation_p.D166N|FAM3A_uc011mzp.1_Missense_Mutation_p.D135N|FAM3A_uc004flu.1_Missense_Mutation_p.D149N|FAM3A_uc011mzq.1_Missense_Mutation_p.D152N|FAM3A_uc004flw.1_Missense_Mutation_p.D152N	NM_021806	NP_068578	P98173	FAM3A_HUMAN	family 3, member A protein precursor	152						extracellular region				large_intestine(1)	1	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GCTGGGTCGTCGTAGGATGCC	0.602		NA											8	16					0	0	0	0
NBPF10	100132406	broad.mit.edu	37	1	145367753	145367753	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr1:145367753delG	uc001end.3	+	85	10609	c.10574delG	c.(10573-10575)AGAfs	p.R3525fs	NBPF9_uc010oye.1_Intron|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_Intron|NBPF10_uc010oyk.1_Intron|NBPF10_uc010oyl.1_Intron	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	3450											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		agaaggggaagaagatcaaag	0.244		NA											13	102	---	---	---	---	NA	NA	NA	NA
MTPAP	55149	broad.mit.edu	37	10	30653930	30653932	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr10:30653930_30653932delTCC	uc001ivb.3	-	9	1622_1624	c.250_252delGGA	c.(250-252)GGAdel	p.G84del	LOC729668_uc001ivd.2_RNA|uc001ive.1_RNA|uc001ivg.1_5'Flank	NM_018109	NP_060579	Q9NVV4	PAPD1_HUMAN	PAP associated domain containing 1 precursor	Error:Variant_position_missing_in_Q9NVV4_after_alignment					cell death|histone mRNA catabolic process|mRNA polyadenylation|transcription, DNA-dependent	mitochondrion	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|protein homodimerization activity|RNA binding|UTP binding			ovary(1)	1						CCTGATGATGTCCTCCTCCTCCT	0.507		NA											7	28	---	---	---	---	NA	NA	NA	NA
TPCN1	53373	broad.mit.edu	37	12	113704096	113704098	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr12:113704096_113704098delCTG	uc001tuw.2	+	4	646_648	c.349_351delCTG	c.(349-351)CTGdel	p.L122del	TPCN1_uc001tux.2_In_Frame_Del_p.L194del|TPCN1_uc010syt.1_In_Frame_Del_p.L54del	NM_017901	NP_060371	Q9ULQ1	TPC1_HUMAN	two pore segment channel 1 isoform 2	122	Helical; Name=S1 of repeat I; (Potential).					endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated ion channel activity			skin(2)|ovary(1)	3						GGCCACGGCCCTGCTGCTGCTGC	0.64		NA											7	552	---	---	---	---	NA	NA	NA	NA
TP53	7157	broad.mit.edu	37	17	7578217	7578218	+	Frame_Shift_Del	DEL	GT	GT	-			TCGA-CR-7386-01A-11D-2012-08	TCGA-CR-7386-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	dac99486-00bc-41ad-92b4-8bed1a28b122	def25278-359f-4d7f-8a33-48f56f668541	g.chr17:7578217_7578218delGT	uc002gim.2	-	6	825_826	c.631_632delAC	c.(631-633)ACTfs	p.T211fs	TP53_uc002gig.1_Frame_Shift_Del_p.T211fs|TP53_uc002gih.2_Frame_Shift_Del_p.T211fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Frame_Shift_Del_p.T79fs|TP53_uc010cng.1_Frame_Shift_Del_p.T79fs|TP53_uc002gii.1_Frame_Shift_Del_p.T79fs|TP53_uc010cnh.1_Frame_Shift_Del_p.T211fs|TP53_uc010cni.1_Frame_Shift_Del_p.T211fs|TP53_uc002gij.2_Frame_Shift_Del_p.T211fs|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Frame_Shift_Del_p.T118fs|TP53_uc002gio.2_Frame_Shift_Del_p.T79fs|TP53_uc010vug.1_Frame_Shift_Del_p.T172fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	211	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		T -> A (in sporadic cancers; somatic mutation).|T -> I (in sporadic cancers; somatic mutation).|T -> N (in sporadic cancers; somatic mutation).|T -> S (in sporadic cancers; somatic mutation).|T -> P (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.T211T(9)|p.T211I(7)|p.0?(7)|p.T211N(4)|p.T211fs*4(3)|p.R209fs*35(2)|p.T211fs*36(2)|p.T211fs*5(2)|p.T211A(2)|p.K164_P219del(1)|p.D208_V216delDRNTFRHSV(1)|p.T211_F212insX(1)|p.R209fs*36(1)|p.D207_R213delDDRNTFR(1)|p.T211_S215delTFRHS(1)|p.D208fs*1(1)|p.R209_R213delRNTFR(1)|p.T211fs*28(1)|p.D207_V216del10(1)|p.T211P(1)|p.T211S(1)|p.R209fs*6(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATGTCGAAAAGTGTTTCTGTCA	0.535		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			12	29	---	---	---	---	NA	NA	NA	NA