Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
C1orf135	79000	broad.mit.edu	37	1	26162205	26162205	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr1:26162205G>T	uc001bkw.1	-	3	353	c.353C>A	c.(352-354)CCT>CAT	p.P118H		NM_024037	NP_076942	Q9H7T9	CA135_HUMAN	aurora A-binding protein	118											0		Colorectal(325;0.000147)|Renal(390;0.00211)|Lung NSC(340;0.00521)|all_lung(284;0.00764)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0675)|all_neural(195;0.117)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0429)|OV - Ovarian serous cystadenocarcinoma(117;3.28e-25)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;1.75e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000787)|BRCA - Breast invasive adenocarcinoma(304;0.00102)|STAD - Stomach adenocarcinoma(196;0.00154)|GBM - Glioblastoma multiforme(114;0.015)|READ - Rectum adenocarcinoma(331;0.0649)		AGTGGCTAAAGGGGATGCCAT	0.483		NA											5	84					0.00116845	0.00931082	1	0
MACF1	23499	broad.mit.edu	37	1	39903546	39903546	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr1:39903546G>C	uc010oiu.1	+	36	13546	c.13415G>C	c.(13414-13416)AGA>ACA	p.R4472T	MACF1_uc010ois.1_Missense_Mutation_p.R3970T	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GACAAGATCAGAGAGTGCATC	0.488		NA											3	134					0	0	0	0
RAVER2	55225	broad.mit.edu	37	1	65243359	65243359	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr1:65243359C>G	uc001dbs.1	+	3	448	c.370C>G	c.(370-372)CAT>GAT	p.H124D	RAVER2_uc001dbt.1_Missense_Mutation_p.H3D|RAVER2_uc010opb.1_Missense_Mutation_p.H3D	NM_018211	NP_060681	Q9HCJ3	RAVR2_HUMAN	ribonucleoprotein, PTB-binding 2	124	RRM 1.					cytoplasm|nucleus	nucleotide binding|RNA binding			large_intestine(1)	1						TCAGATGTTTCATCAATATTC	0.328		NA											3	111					0	0	0	0
FCGR1A	2209	broad.mit.edu	37	1	149761632	149761632	+	Silent	SNP	G	G	A			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr1:149761632G>A	uc001esp.3	+	5	632	c.582G>A	c.(580-582)CTG>CTA	p.L194L	HIST2H2BF_uc010pbj.1_Intron|FCGR1A_uc009wlg.2_Intron	NM_000566	NP_000557	P12314	FCGR1_HUMAN	Fc fragment of IgG, high affinity Ia, receptor	194	Extracellular (Potential).|Ig-like C2-type 3.				interferon-gamma-mediated signaling pathway|phagocytosis, engulfment	integral to membrane|plasma membrane	IgG binding|receptor activity|receptor signaling protein activity			ovary(1)	1	Breast(34;0.0124)|all_hematologic(923;0.127)				Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Methyl aminolevulinate(DB00992)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Porfimer(DB00707)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	CTCCAGTGCTGAATGCATCTG	0.498		NA											5	65					0	0	0	0
HRNR	388697	broad.mit.edu	37	1	152191393	152191393	+	Silent	SNP	G	G	T			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr1:152191393G>T	uc001ezt.1	-	3	2788	c.2712C>A	c.(2710-2712)CCC>CCA	p.P904P		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	904	10				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGCCATAGCTGGGAGACTGCC	0.647		NA											30	175					3.99e-17	3.44e-16	1	0
ZBTB7B	51043	broad.mit.edu	37	1	154987971	154987971	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr1:154987971G>A	uc001fgk.3	+	3	993	c.835G>A	c.(835-837)GAA>AAA	p.E279K	ZBTB7B_uc009wpa.2_Missense_Mutation_p.E279K|ZBTB7B_uc001fgj.3_Missense_Mutation_p.E313K|ZBTB7B_uc010peq.1_Missense_Mutation_p.E313K|ZBTB7B_uc001fgl.3_Missense_Mutation_p.E279K	NM_015872	NP_056956	O15156	ZBT7B_HUMAN	zinc finger and BTB domain containing 7B	279					cell differentiation|ectoderm development|multicellular organismal development|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding				0	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			TGAGGAAGAAGAAGAGGAGCT	0.657		NA											6	29					0	0	0	0
TRAF5	7188	broad.mit.edu	37	1	211545470	211545470	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr1:211545470C>A	uc001hih.2	+	11	1160	c.1100C>A	c.(1099-1101)GCC>GAC	p.A367D	TRAF5_uc001hii.2_Missense_Mutation_p.A367D|TRAF5_uc010psx.1_Missense_Mutation_p.A378D|TRAF5_uc010psy.1_Missense_Mutation_p.A261D|TRAF5_uc001hij.2_Missense_Mutation_p.A367D	NM_004619	NP_004610	O00463	TRAF5_HUMAN	TNF receptor-associated factor 5	367					apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis	CD40 receptor complex|centrosome|internal side of plasma membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)|breast(2)|ovary(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00946)|all cancers(67;0.0808)|Epithelial(68;0.144)		TTATTTGCAGCCGTTTTAGAA	0.318		NA											17	52					3.41e-10	2.9e-09	1	0
SMYD2	56950	broad.mit.edu	37	1	214478569	214478569	+	Silent	SNP	A	A	C			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr1:214478569A>C	uc010ptx.1	+	2	246	c.213A>C	c.(211-213)GCA>GCC	p.A71A	SMYD2_uc009xdj.2_Intron|SMYD2_uc010ptw.1_Intron|SMYD2_uc009xdl.1_RNA	NM_020197	NP_064582	Q9NRG4	SMYD2_HUMAN	SET and MYND domain containing 2	71	MYND-type.				negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation|regulation of DNA damage response, signal transduction by p53 class mediator|transcription, DNA-dependent	cytosol|nucleus	histone methyltransferase activity (H3-K36 specific)|p53 binding|RNA polymerase II core binding|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0122)|all cancers(67;0.0209)|GBM - Glioblastoma multiforme(131;0.106)|Epithelial(68;0.144)		GCAAGCAGGCATTTTACTGCA	0.473		NA											32	109					0	0	0	0
SYNPO2L	79933	broad.mit.edu	37	10	75406952	75406952	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr10:75406952A>G	uc001jut.3	-	4	2610	c.2458T>C	c.(2458-2460)TTT>CTT	p.F820L	SYNPO2L_uc001jus.3_Missense_Mutation_p.F596L	NM_001114133	NP_001107605	Q9H987	SYP2L_HUMAN	synaptopodin 2-like isoform a	820	Pro-rich.					cytoplasm|cytoskeleton	actin binding			ovary(1)	1	Prostate(51;0.0112)					TGGGGGAAAAAGGGAGAGAGC	0.577		NA											3	116					0	0	0	0
CYP2C9	1559	broad.mit.edu	37	10	96708979	96708979	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr10:96708979G>A	uc001kka.3	+	5	782	c.757G>A	c.(757-759)GAA>AAA	p.E253K	CYP2C9_uc009xut.2_Missense_Mutation_p.E253K	NM_000771	NP_000762	P11712	CP2C9_HUMAN	cytochrome P450, family 2, subfamily C,	253					exogenous drug catabolic process|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid metabolic process|urea metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|caffeine oxidase activity|drug binding|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			skin(4)|ovary(2)	6		Colorectal(252;0.0902)		all cancers(201;6.93e-05)	Acenocoumarol(DB01418)|Alosetron(DB00969)|Amiodarone(DB01118)|Antihemophilic Factor(DB00025)|Aprepitant(DB00673)|Bosentan(DB00559)|Carprofen(DB00821)|Carvedilol(DB01136)|Celecoxib(DB00482)|Clomipramine(DB01242)|Dapsone(DB00250)|Delavirdine(DB00705)|Desloratadine(DB00967)|Desogestrel(DB00304)|Diclofenac(DB00586)|Esomeprazole(DB00736)|Etodolac(DB00749)|Fluconazole(DB00196)|Fluoxetine(DB00472)|Flurbiprofen(DB00712)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Gemfibrozil(DB01241)|Ginkgo biloba(DB01381)|Glibenclamide(DB01016)|Glimepiride(DB00222)|Glipizide(DB01067)|Guanfacine(DB01018)|Hydromorphone(DB00327)|Ibuprofen(DB01050)|Imipramine(DB00458)|Irbesartan(DB01029)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Losartan(DB00678)|Lumiracoxib(DB01283)|Marinol(DB00470)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mephenytoin(DB00532)|Metronidazole(DB00916)|Miconazole(DB01110)|Midazolam(DB00683)|Montelukast(DB00471)|Nateglinide(DB00731)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Oxymorphone(DB01192)|Pantoprazole(DB00213)|Paramethadione(DB00617)|Phenprocoumon(DB00946)|Phenytoin(DB00252)|Pravastatin(DB00175)|Quinidine(DB00908)|Ritonavir(DB00503)|Rosiglitazone(DB00412)|Sertraline(DB01104)|Sildenafil(DB00203)|Sulfamethoxazole(DB01015)|Suprofen(DB00870)|Tamoxifen(DB00675)|Tenoxicam(DB00469)|Terfenadine(DB00342)|Tolbutamide(DB01124)|Torasemide(DB00214)|Troleandomycin(DB01361)|Valdecoxib(DB00580)|Valsartan(DB00177)|Voriconazole(DB00582)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zileuton(DB00744)	AGAACACCAAGAATCAATGGA	0.333		NA											6	45					0	0	0	0
OR51L1	119682	broad.mit.edu	37	11	5021081	5021081	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr11:5021081A>G	uc010qyu.1	+	1	869	c.869A>G	c.(868-870)AAC>AGC	p.N290S		NM_001004755	NP_001004755	Q8NGJ5	O51L1_HUMAN	olfactory receptor, family 51, subfamily L,	290	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.75e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		CCAGTCCTTAACCCTATTGTC	0.458		NA											5	43					0	0	0	0
ODZ4	26011	broad.mit.edu	37	11	78413296	78413296	+	Silent	SNP	G	G	A			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr11:78413296G>A	uc001ozl.3	-	28	4825	c.4362C>T	c.(4360-4362)GAC>GAT	p.D1454D	ODZ4_uc009yvb.1_Silent_p.D38D	NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	1454	Extracellular (Potential).				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						GCAGGAAGTGGTCAATGCCAG	0.547		NA											9	41					0	0	0	0
CCDC89	220388	broad.mit.edu	37	11	85396815	85396815	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr11:85396815C>T	uc001pau.1	-	1	506	c.359G>A	c.(358-360)CGG>CAG	p.R120Q		NM_152723	NP_689936	Q8N998	CCD89_HUMAN	coiled-coil domain containing 89	120	Potential.					cytoplasm|nucleus					0		Acute lymphoblastic leukemia(157;4.88e-06)|all_hematologic(158;0.00572)				CTCTAGTTTCCGACTGTACTC	0.542		NA											6	103					0	0	0	0
CWF19L2	143884	broad.mit.edu	37	11	107224441	107224441	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr11:107224441C>G	uc010rvp.1	-	13	1924	c.1894G>C	c.(1894-1896)GAC>CAC	p.D632H	CWF19L2_uc001pjh.3_RNA|CWF19L2_uc009yxo.2_Intron	NM_152434	NP_689647	Q2TBE0	C19L2_HUMAN	CWF19-like 2, cell cycle control	632							catalytic activity				0		Melanoma(852;1.75e-05)|all_epithelial(67;6.27e-05)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0258)		Epithelial(105;7.18e-06)|BRCA - Breast invasive adenocarcinoma(274;1.65e-05)|all cancers(92;1.76e-05)		GTGTAATAGTCTCCATCTGTT	0.388		NA											14	75					0	0	0	0
A2ML1	144568	broad.mit.edu	37	12	9027036	9027036	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr12:9027036C>G	uc001quz.3	+	34	4335	c.4237C>G	c.(4237-4239)CAG>GAG	p.Q1413E	A2ML1_uc001qva.1_Missense_Mutation_p.Q993E|A2ML1_uc010sgm.1_Missense_Mutation_p.Q913E|A2ML1_uc001qvb.1_RNA	NM_144670	NP_653271	A8K2U0	A2ML1_HUMAN	alpha-2-macroglobulin-like 1 precursor	1257						extracellular space	endopeptidase inhibitor activity			ovary(2)|skin(1)	3						TAAGAACACTCAGACTTACAC	0.433		NA											18	54					0	0	0	0
TM7SF3	51768	broad.mit.edu	37	12	27149786	27149786	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr12:27149786G>A	uc010sjl.1	-	4	645	c.407C>T	c.(406-408)CCT>CTT	p.P136L		NM_016551	NP_057635	Q9NS93	TM7S3_HUMAN	transmembrane 7 superfamily member 3 precursor	136						integral to membrane|plasma membrane				upper_aerodigestive_tract(2)	2	Colorectal(261;0.0847)					ACAGCCTCCAGGGACAGGATC	0.353		NA											4	22					0	0	0	0
MDM1	56890	broad.mit.edu	37	12	68724993	68724993	+	Silent	SNP	A	A	G			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr12:68724993A>G	uc001stz.2	-	2	163	c.27T>C	c.(25-27)AGT>AGC	p.S9S	MDM1_uc010stc.1_Silent_p.S9S|MDM1_uc009zqv.1_5'UTR|MDM1_uc001sua.3_Silent_p.S9S|MDM1_uc010std.1_Silent_p.S9S	NM_017440	NP_059136	Q8TC05	MDM1_HUMAN	mouse Mdm1 nuclear protein homolog isoform 1	9						nucleus				ovary(3)|skin(2)	5			Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;0.000174)		TCTGGTATTCACTCAGCCCCT	0.418		NA											9	161					0	0	0	0
NAV3	89795	broad.mit.edu	37	12	78400292	78400292	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr12:78400292C>T	uc001syp.2	+	8	1147	c.974C>T	c.(973-975)TCT>TTT	p.S325F	NAV3_uc001syo.2_Missense_Mutation_p.S325F	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	325						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						GCCATCCCTTCTCCAAGTGCC	0.547		NA								HNSCC(70;0.22)			14	65					0	0	0	0
STYX	6815	broad.mit.edu	37	14	53223283	53223283	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr14:53223283A>T	uc010tqy.1	+	6	319	c.257A>T	c.(256-258)GAT>GTT	p.D86V	STYX_uc001xaa.2_Missense_Mutation_p.D86V	NM_001130701	NP_001124173	Q8WUJ0	STYX_HUMAN	serine/threonine/tyrosine interacting protein	86					protein dephosphorylation|spermatogenesis	cytoplasm	protein tyrosine/serine/threonine phosphatase activity				0	Breast(41;0.176)					TTAGTCCTGGATATTGCAGAT	0.244		NA											8	49					0	0	0	0
MAPKBP1	23005	broad.mit.edu	37	15	42111558	42111558	+	Silent	SNP	G	G	A			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr15:42111558G>A	uc001zok.3	+	22	2710	c.2424G>A	c.(2422-2424)AAG>AAA	p.K808K	MAPKBP1_uc001zoj.3_Silent_p.K802K|MAPKBP1_uc010bcj.2_Silent_p.K309K|MAPKBP1_uc010bci.2_Silent_p.K802K|MAPKBP1_uc010udb.1_Silent_p.K641K|MAPKBP1_uc010bck.2_5'UTR|MAPKBP1_uc010bcl.2_Silent_p.K309K	NM_001128608	NP_001122080	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein	808										central_nervous_system(5)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	10		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		TCCTTGCCAAGAGTACCAAGA	0.542		NA											13	116					0	0	0	0
LRRC57	255252	broad.mit.edu	37	15	42839505	42839505	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr15:42839505G>A	uc001zqd.1	-	3	814	c.446C>T	c.(445-447)TCA>TTA	p.S149L	HAUS2_uc001zqe.2_5'Flank|HAUS2_uc010udi.1_5'Flank|HAUS2_uc001zqf.2_5'Flank|LRRC57_uc001zqc.2_Missense_Mutation_p.S149L	NM_153260	NP_694992	Q8N9N7	LRC57_HUMAN	leucine rich repeat containing 57	149	LRR 5.										0		all_cancers(109;1.99e-12)|all_epithelial(112;5.11e-11)|Lung NSC(122;4.53e-07)|all_lung(180;1.64e-06)|Melanoma(134;0.0262)		GBM - Glioblastoma multiforme(94;6.87e-07)		CTCTCCCACTGAGTCAGGTAT	0.468		NA											7	84					0	0	0	0
ZNF592	9640	broad.mit.edu	37	15	85341886	85341886	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr15:85341886C>G	uc002bld.2	+	8	3140	c.2804C>G	c.(2803-2805)TCA>TGA	p.S935*	ZNF592_uc010upb.1_RNA	NM_014630	NP_055445	Q92610	ZN592_HUMAN	zinc finger protein 592	935					cell death|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(2)	6			BRCA - Breast invasive adenocarcinoma(143;0.0587)			GACACATCCTCAAGCCGCCCT	0.632		NA											9	50					0	0	0	0
SEZ6L2	26470	broad.mit.edu	37	16	29888272	29888272	+	Splice_Site	SNP	C	C	T			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr16:29888272C>T	uc002duq.3	-	12	2150	c.1910_splice	c.e12-1	p.E637_splice	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SEZ6L2_uc002dup.3_Splice_Site_p.E567_splice|SEZ6L2_uc002dur.3_Splice_Site_p.E567_splice|SEZ6L2_uc002dus.3_Splice_Site_p.E523_splice|SEZ6L2_uc010vec.1_Splice_Site_p.E637_splice|SEZ6L2_uc010ved.1_Splice_Site_p.E593_splice	NM_201575	NP_963869	Q6UXD5	SE6L2_HUMAN	seizure related 6 homolog (mouse)-like 2 isoform							endoplasmic reticulum membrane|integral to membrane|plasma membrane				ovary(1)|skin(1)	2						CTCGGGACCTCTGCAGGGGAG	0.652		NA											3	18					0	0	0	0
MYST1	84148	broad.mit.edu	37	16	31138398	31138398	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr16:31138398G>A	uc002eay.2	+	4	523	c.505G>A	c.(505-507)GAG>AAG	p.E169K	MYST1_uc002eax.2_Missense_Mutation_p.E169K|MYST1_uc002eaz.2_Missense_Mutation_p.E11K|MYST1_uc002eba.2_5'Flank|MYST1_uc002ebb.2_5'Flank	NM_032188	NP_115564	Q9H7Z6	MYST1_HUMAN	MYST histone acetyltransferase 1 isoform 1	169					histone H4-K16 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex|MSL complex	histone acetyltransferase activity|metal ion binding|methylated histone residue binding|transcription factor binding			ovary(1)	1						CTTGGAGAAGGAGCATGAGGC	0.622		NA											13	47					0	0	0	0
NMT1	4836	broad.mit.edu	37	17	43175832	43175832	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr17:43175832G>C	uc002ihz.2	+	7	814	c.796G>C	c.(796-798)GAG>CAG	p.E266Q	NMT1_uc002iia.2_RNA	NM_021079	NP_066565	P30419	NMT1_HUMAN	N-myristoyltransferase 1	266					activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals|N-terminal protein myristoylation|protein lipoylation	actin cytoskeleton|cell junction|cytosol	glycylpeptide N-tetradecanoyltransferase activity				0		Prostate(33;0.155)				TCTGATCCGAGAGATCACCAG	0.522		NA											4	127					0	0	0	0
NDUFS7	374291	broad.mit.edu	37	19	1387822	1387822	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr19:1387822G>A	uc002lse.3	+	2	72	c.29G>A	c.(28-30)CGC>CAC	p.R10H	NDUFS7_uc002lsf.2_Missense_Mutation_p.R74H|NDUFS7_uc002lsh.2_Missense_Mutation_p.R74H|NDUFS7_uc002lsg.2_5'UTR	NM_024407	NP_077718	O75251	NDUS7_HUMAN	NADH-ubiquinone oxidoreductase Fe-S protein 7	10					mitochondrial electron transport, NADH to ubiquinone|mitochondrial respiratory chain complex I assembly|transport	mitochondrial respiratory chain complex I	4 iron, 4 sulfur cluster binding|metal ion binding|NADH dehydrogenase (ubiquinone) activity|protein binding|quinone binding				0		Acute lymphoblastic leukemia(61;5.61e-13)|all_hematologic(61;2.65e-08)|Breast(49;0.00186)|Lung NSC(49;0.00292)|all_lung(49;0.00419)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	NADH(DB00157)	CCTGGCCTGCGCGGCTTCCGG	0.711		NA											9	41					0	0	0	0
ATP8B3	148229	broad.mit.edu	37	19	1802615	1802615	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr19:1802615G>A	uc002ltw.2	-	11	1168	c.934C>T	c.(934-936)CGG>TGG	p.R312W	ATP8B3_uc002ltv.2_Missense_Mutation_p.R259W|ATP8B3_uc002ltx.2_RNA|ATP8B3_uc002lty.1_Missense_Mutation_p.R60W|ATP8B3_uc002ltz.1_Missense_Mutation_p.R259W	NM_138813	NP_620168	O60423	AT8B3_HUMAN	ATPase, class I, type 8B, member 3	312	Cytoplasmic (Potential).				ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGGTGCATCCGACTGTTAGGC	0.612		NA											7	20					0	0	0	0
FBN3	84467	broad.mit.edu	37	19	8152087	8152087	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr19:8152087C>T	uc002mjf.2	-	53	6649	c.6628G>A	c.(6628-6630)GAG>AAG	p.E2210K	FBN3_uc002mje.2_Missense_Mutation_p.E49K	NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	2210	EGF-like 36; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						TCTGCACACTCGTCCACATCT	0.632		NA											6	54					0	0	0	0
SLC44A2	57153	broad.mit.edu	37	19	10742817	10742817	+	Silent	SNP	C	C	T			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr19:10742817C>T	uc002mpf.2	+	10	947	c.808C>T	c.(808-810)CTG>TTG	p.L270L	SLC44A2_uc002mpe.3_Silent_p.L268L|SLC44A2_uc002mpg.1_5'Flank	NM_020428	NP_065161	Q8IWA5	CTL2_HUMAN	solute carrier family 44, member 2 isoform 1	270	Helical; (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane|plasma membrane	choline transmembrane transporter activity|signal transducer activity			ovary(1)	1			Epithelial(33;8.7e-06)|all cancers(31;2.77e-05)		Choline(DB00122)	CATGGTGATTCTGGTGCTGGG	0.562		NA											5	131					0	0	0	0
LILRB2	10288	broad.mit.edu	37	19	54782209	54782209	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr19:54782209G>C	uc002qfb.2	-	7	1429	c.1163C>G	c.(1162-1164)TCA>TGA	p.S388*	LILRA6_uc002qew.1_Intron|LILRB2_uc010eri.2_Nonsense_Mutation_p.S388*|LILRB2_uc010erj.2_RNA|LILRB2_uc002qfc.2_Nonsense_Mutation_p.S388*|LILRB2_uc010yet.1_Nonsense_Mutation_p.S272*|LILRB2_uc010yeu.1_RNA	NM_005874	NP_005865	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor,	388	Extracellular (Potential).|Ig-like C2-type 4.				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			skin(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CGCGTGGGCTGAGGTCACAGG	0.592		NA											4	158					0	0	0	0
CHRND	1144	broad.mit.edu	37	2	233393036	233393036	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr2:233393036T>C	uc002vsw.2	+	4	312	c.308T>C	c.(307-309)CTC>CCC	p.L103P	CHRND_uc010zmg.1_Missense_Mutation_p.L88P|CHRND_uc010fyc.2_Missense_Mutation_p.S13P|CHRND_uc010zmh.1_Missense_Mutation_p.S13P	NM_000751	NP_000742	Q07001	ACHD_HUMAN	nicotinic acetylcholine receptor delta	103	Extracellular (Potential).				muscle contraction|musculoskeletal movement|neuromuscular process|skeletal muscle tissue growth|synaptic transmission	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			ovary(1)|breast(1)|skin(1)	3		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.89e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00078)|Lung(119;0.00579)|LUSC - Lung squamous cell carcinoma(224;0.00754)		GTCCTGCGCCTCCCCCCGGAC	0.567		NA											3	56					0	0	0	0
DIP2A	23181	broad.mit.edu	37	21	47959793	47959793	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr21:47959793C>T	uc002zjo.2	+	17	2108	c.1925C>T	c.(1924-1926)TCG>TTG	p.S642L	DIP2A_uc011afy.1_Missense_Mutation_p.S578L|DIP2A_uc011afz.1_Missense_Mutation_p.S638L|DIP2A_uc002zjl.2_Missense_Mutation_p.S642L|DIP2A_uc002zjm.2_Missense_Mutation_p.S642L|DIP2A_uc010gql.2_Missense_Mutation_p.S599L|DIP2A_uc002zjn.2_Missense_Mutation_p.S642L|DIP2A_uc002zjp.1_Missense_Mutation_p.S387L|DIP2A_uc002zjq.2_Missense_Mutation_p.S34L	NM_015151	NP_055966	Q14689	DIP2A_HUMAN	disco-interacting protein 2A isoform a	642					multicellular organismal development	nucleus	catalytic activity|transcription factor binding			ovary(2)	2	Breast(49;0.0933)			Epithelial(3;3.12e-06)|OV - Ovarian serous cystadenocarcinoma(3;5.68e-06)|all cancers(3;4.08e-05)|Colorectal(79;0.0129)|COAD - Colon adenocarcinoma(84;0.0824)		TGTGCAGGGTCGATCTCCTCC	0.597		NA											33	72					0	0	0	0
MTMR14	64419	broad.mit.edu	37	3	9726305	9726305	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr3:9726305G>C	uc003brz.2	+	11	1125	c.1001G>C	c.(1000-1002)TGG>TCG	p.W334S	MTMR14_uc003bsa.2_Missense_Mutation_p.W334S|MTMR14_uc003bsb.2_Missense_Mutation_p.W334S|MTMR14_uc011ath.1_RNA|MTMR14_uc010hcl.2_Missense_Mutation_p.W88S|MTMR14_uc003bsc.2_RNA	NM_001077525	NP_001070993	Q8NCE2	MTMRE_HUMAN	jumpy isoform 2	334						perinuclear region of cytoplasm|ruffle	phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity			skin(1)	1	Medulloblastoma(99;0.227)					ATCTCAGGCTGGGATCGGACC	0.577		NA											4	80					0	0	0	0
XIRP1	165904	broad.mit.edu	37	3	39230859	39230859	+	Silent	SNP	T	T	G			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr3:39230859T>G	uc003cjk.1	-	2	299	c.78A>C	c.(76-78)CCA>CCC	p.P26P	XIRP1_uc003cji.2_Silent_p.P26P|XIRP1_uc003cjj.2_Intron	NM_194293	NP_919269	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	26	Interaction with VASP.|Poly-Pro.						actin binding			ovary(4)|breast(2)|central_nervous_system(1)|pancreas(1)	8				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		GGGCTGGGGGTGGAGGGAGGG	0.637		NA											5	22					0	0	0	0
NKTR	4820	broad.mit.edu	37	3	42679772	42679772	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr3:42679772G>A	uc003clo.2	+	13	2723	c.2576G>A	c.(2575-2577)AGA>AAA	p.R859K	NKTR_uc003clm.1_Missense_Mutation_p.R606K|NKTR_uc003clp.2_Missense_Mutation_p.R606K|NKTR_uc011azp.1_Intron|NKTR_uc003clq.1_Missense_Mutation_p.R749K|NKTR_uc003clr.1_Missense_Mutation_p.R606K|NKTR_uc003cls.2_Missense_Mutation_p.R559K	NM_005385	NP_005376	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence	859					protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			ovary(2)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(284;0.24)		TCAAAAAAAAGAACTTTGAAA	0.373		NA											7	49					0	0	0	0
STAB1	23166	broad.mit.edu	37	3	52544478	52544478	+	Silent	SNP	T	T	C			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr3:52544478T>C	uc003dej.2	+	25	2816	c.2742T>C	c.(2740-2742)GGT>GGC	p.G914G		NM_015136	NP_055951	Q9NY15	STAB1_HUMAN	stabilin 1 precursor	914	Extracellular (Potential).|EGF-like 8.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			large_intestine(3)|upper_aerodigestive_tract(2)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	9				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		ACATGAGAGGTGGCTGCCACA	0.647		NA											16	33					0	0	0	0
PEX5L	51555	broad.mit.edu	37	3	179525565	179525565	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr3:179525565C>T	uc003fki.1	-	14	1703	c.1573G>A	c.(1573-1575)GAG>AAG	p.E525K	PEX5L_uc011bqd.1_Missense_Mutation_p.E482K|PEX5L_uc011bqe.1_Missense_Mutation_p.E333K|PEX5L_uc011bqf.1_Missense_Mutation_p.E417K|PEX5L_uc003fkj.1_Missense_Mutation_p.E490K|PEX5L_uc010hxd.1_Missense_Mutation_p.E523K|PEX5L_uc011bqg.1_Missense_Mutation_p.E501K|PEX5L_uc011bqh.1_Missense_Mutation_p.E466K	NM_016559	NP_057643	Q8IYB4	PEX5R_HUMAN	peroxisomal biogenesis factor 5-like	525	TPR 4.				protein import into peroxisome matrix|regulation of cAMP-mediated signaling	cytosol|peroxisomal membrane	peroxisome matrix targeting signal-1 binding			ovary(3)|large_intestine(1)	4	all_cancers(143;3.94e-14)|Ovarian(172;0.0338)|Breast(254;0.183)		OV - Ovarian serous cystadenocarcinoma(80;1.75e-26)|GBM - Glioblastoma multiforme(14;0.000518)			ACGGCTTCCTCGCTGCGGTCT	0.537		NA											28	227					0	0	0	0
AMBN	258	broad.mit.edu	37	4	71467197	71467197	+	Silent	SNP	A	A	G			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr4:71467197A>G	uc003hfl.2	+	6	432	c.357A>G	c.(355-357)CAA>CAG	p.Q119Q		NM_016519	NP_057603	Q9NP70	AMBN_HUMAN	ameloblastin precursor	119					bone mineralization|cell adhesion|cell proliferation|odontogenesis of dentine-containing tooth	proteinaceous extracellular matrix	growth factor activity|structural constituent of tooth enamel			ovary(3)|skin(1)	4			Lung(101;0.235)			TGAAGCCTCAACAGCCAGGAC	0.502		NA									OREG0016218	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	53	146					0	0	0	0
GPX8	493869	broad.mit.edu	37	5	54456872	54456872	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr5:54456872T>G	uc003jpq.2	+	2	292	c.255T>G	c.(253-255)AAT>AAG	p.N85K	CDC20B_uc003jpn.1_Intron|CDC20B_uc010ivu.1_Intron|CDC20B_uc003jpo.1_Intron|CDC20B_uc010ivv.1_Intron|CDC20B_uc003jpp.2_Intron|GPX8_uc003jpr.2_Intron|GPX8_uc003jps.2_RNA|GPX8_uc003jpt.2_Missense_Mutation_p.N34K	NM_001008397	NP_001008398	Q8TED1	GPX8_HUMAN	glutathione peroxidase 8	85					response to oxidative stress	integral to membrane	glutathione peroxidase activity				0					Glutathione(DB00143)	CAGACAGAAATTACTTAGGGC	0.463		NA											13	35					0	0	0	0
AP3B1	8546	broad.mit.edu	37	5	77590312	77590312	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr5:77590312G>A	uc003kfj.2	-	1	217	c.92C>T	c.(91-93)TCG>TTG	p.S31L		NM_003664	NP_003655	O00203	AP3B1_HUMAN	adaptor-related protein complex 3, beta 1	31					endocytosis|melanosome organization	clathrin coated vesicle membrane|Golgi apparatus|membrane coat	protein phosphatase binding|protein transporter activity			central_nervous_system(1)	1		all_lung(232;0.000397)|Lung NSC(167;0.00106)|Ovarian(174;0.0105)|Prostate(461;0.215)		OV - Ovarian serous cystadenocarcinoma(54;8.23e-47)|Epithelial(54;2.74e-41)|all cancers(79;4.8e-36)		GAAGGCCCCCGAGGGGGAAAT	0.607		NA							Hermansky-Pudlak_syndrome				12	73					0	0	0	0
BRD8	10902	broad.mit.edu	37	5	137500599	137500599	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr5:137500599G>A	uc003lcf.1	-	12	1590	c.1535C>T	c.(1534-1536)CCT>CTT	p.P512L	BRD8_uc003lcc.1_RNA|BRD8_uc011cyl.1_Missense_Mutation_p.P291L|BRD8_uc003lcg.2_Missense_Mutation_p.P585L|BRD8_uc003lci.2_Missense_Mutation_p.P515L|BRD8_uc003lch.2_Missense_Mutation_p.P406L|BRD8_uc011cym.1_Missense_Mutation_p.P496L|BRD8_uc010jer.1_Missense_Mutation_p.P481L|BRD8_uc011cyn.1_Missense_Mutation_p.P471L	NM_139199	NP_631938	Q9H0E9	BRD8_HUMAN	bromodomain containing 8 isoform 2	512					cell surface receptor linked signaling pathway|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription from RNA polymerase II promoter	mitochondrion|NuA4 histone acetyltransferase complex	sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			TGGTTCTGCAGGTTCCACCTT	0.502		NA											6	122					0	0	0	0
FAM53C	51307	broad.mit.edu	37	5	137680937	137680937	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr5:137680937G>A	uc003lcv.2	+	4	1030	c.560G>A	c.(559-561)AGA>AAA	p.R187K	FAM53C_uc003lcw.2_Missense_Mutation_p.R187K|FAM53C_uc011cyq.1_Intron|FAM53C_uc011cyr.1_Intron	NM_001135647	NP_001129119	Q9NYF3	FA53C_HUMAN	hypothetical protein LOC51307	187										ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			CCAGCTCACAGACCCTACAGC	0.642		NA											43	213					0	0	0	0
NSD1	64324	broad.mit.edu	37	5	176687121	176687121	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr5:176687121C>T	uc003mfr.3	+	14	5236	c.5098C>T	c.(5098-5100)CGA>TGA	p.R1700*	NSD1_uc003mft.3_Nonsense_Mutation_p.R1431*|NSD1_uc003mfs.1_Nonsense_Mutation_p.R1597*|NSD1_uc011dfx.1_Nonsense_Mutation_p.R1348*	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1700					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		GCGGGGCTGCCGAAATCATGA	0.433		NA	T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			5	59					0	0	0	0
HIST1H2AB	8335	broad.mit.edu	37	6	26033429	26033429	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr6:26033429C>G	uc003nft.1	-	1	368	c.368G>C	c.(367-369)AGC>ACC	p.S123T	HIST1H3B_uc003nfs.1_5'Flank	NM_003513	NP_003504	P04908	H2A1B_HUMAN	histone cluster 1, H2ab	123					nucleosome assembly	nucleosome|nucleus	DNA binding				0						CTTATGATGGCTCTCAGTTTT	0.478		NA											9	68					0	0	0	0
ZNF76	7629	broad.mit.edu	37	6	35262305	35262305	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr6:35262305G>A	uc003oki.1	+	13	1772	c.1567G>A	c.(1567-1569)GCA>ACA	p.A523T	ZNF76_uc003okj.1_Missense_Mutation_p.A468T	NM_003427	NP_003418	P36508	ZNF76_HUMAN	zinc finger protein 76 (expressed in testis)	523					regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TCAACAGGTGGCACTGTTGGC	0.517		NA									OREG0017373	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	56					0	0	0	0
PRPH2	5961	broad.mit.edu	37	6	42689524	42689524	+	Silent	SNP	G	G	A			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr6:42689524G>A	uc003osk.2	-	1	835	c.549C>T	c.(547-549)CGC>CGT	p.R183R		NM_000322	NP_000313	P23942	PRPH2_HUMAN	peripherin 2	183	Lumenal (Potential).				cell adhesion|visual perception	integral to membrane				ovary(4)|central_nervous_system(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.00178)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.0904)			AGTCCAGGTAGCGATTGCTGA	0.493		NA											18	141					0	0	0	0
TJAP1	93643	broad.mit.edu	37	6	43472753	43472753	+	Silent	SNP	G	G	A			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr6:43472753G>A	uc003ovd.2	+	11	1210	c.834G>A	c.(832-834)CCG>CCA	p.P278P	TJAP1_uc003ovf.2_Silent_p.P268P|TJAP1_uc003ove.2_Silent_p.P268P|TJAP1_uc003ovc.2_Silent_p.P268P|TJAP1_uc010jyp.2_Silent_p.P237P|TJAP1_uc011dvh.1_Silent_p.P268P|TJAP1_uc003ovg.2_Silent_p.P144P|TJAP1_uc011dvi.1_Silent_p.P278P|TJAP1_uc011dvj.1_Silent_p.P78P|TJAP1_uc003ovi.2_Silent_p.P144P	NM_001146016	NP_001139488	Q5JTD0	TJAP1_HUMAN	tight junction associated protein 1 isoform a	278	Pro-rich.					Golgi apparatus|tight junction	protein binding				0	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0122)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			CCAGTCCCCCGGCCCCTGGCA	0.657		NA											9	52					0	0	0	0
ECT2L	345930	broad.mit.edu	37	6	139167812	139167812	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr6:139167812G>A	uc003qif.1	+	6	1004	c.901G>A	c.(901-903)GAG>AAG	p.E301K	ECT2L_uc011edq.1_Missense_Mutation_p.E232K	NM_001077706	NP_001071174	Q008S8	ECT2L_HUMAN	epithelial cell transforming sequence 2	301					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity				0						TCCTGCGTATGAGGTAGAGTA	0.398		NA											7	273					0	0	0	0
AKAP12	9590	broad.mit.edu	37	6	151670504	151670504	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr6:151670504G>C	uc011eep.1	+	4	1218	c.978G>C	c.(976-978)AAG>AAC	p.K326N	AKAP12_uc003qoe.2_Missense_Mutation_p.K326N|AKAP12_uc003qof.2_Missense_Mutation_p.K228N|AKAP12_uc010kim.2_Intron|AKAP12_uc003qog.2_Missense_Mutation_p.K221N	NM_005100	NP_005091	Q02952	AKA12_HUMAN	A kinase (PRKA) anchor protein 12 isoform 1	326	Involved in PKC-binding (Probable).				G-protein coupled receptor protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting	cell cortex|cytoskeleton|plasma membrane	adenylate cyclase binding|protein kinase A binding			large_intestine(2)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	8		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.98e-11)		CTTCAGAGAAGAAAAAGGAAC	0.507		NA											10	45					0	0	0	0
CYTH3	9265	broad.mit.edu	37	7	6226735	6226735	+	Silent	SNP	C	C	T			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr7:6226735C>T	uc003spt.2	-	4	299	c.195G>A	c.(193-195)CAG>CAA	p.Q65Q		NM_004227	NP_004218	O43739	CYH3_HUMAN	cytohesin 3	65					regulation of ARF protein signal transduction|regulation of cell adhesion|vesicle-mediated transport	cytoplasm|membrane fraction|plasma membrane	1-phosphatidylinositol binding|ARF guanyl-nucleotide exchange factor activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity				0						GTTTGTTCCTCTGAGTCGTTT	0.443		NA											28	156					0	0	0	0
LINGO2	158038	broad.mit.edu	37	9	27949880	27949880	+	Missense_Mutation	SNP	C	C	A	rs148104069		TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr9:27949880C>A	uc003zqu.1	-	2	984	c.790G>T	c.(790-792)GTA>TTA	p.V264L	LINGO2_uc010mjf.1_Missense_Mutation_p.V264L|LINGO2_uc003zqv.1_Missense_Mutation_p.V264L	NM_152570	NP_689783	Q7L985	LIGO2_HUMAN	leucine rich repeat and Ig domain containing 2	264	LRR 9.|Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	Melanoma(11;0.242)	all_neural(11;2.78e-09)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0818)|GBM - Glioblastoma multiforme(2;1.31e-34)|all cancers(2;2.37e-25)|Lung(2;7.48e-08)|LUSC - Lung squamous cell carcinoma(38;5.09e-07)|KIRC - Kidney renal clear cell carcinoma(2;0.0465)|Kidney(2;0.0604)		AGGAAGGGTACAGTAGACAGA	0.463		NA											26	124					1.74e-06	1.47e-05	1	0
GOLM1	51280	broad.mit.edu	37	9	88650358	88650358	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr9:88650358C>G	uc004aol.2	-	8	1138	c.940G>C	c.(940-942)GAG>CAG	p.E314Q	GOLM1_uc004aom.2_Missense_Mutation_p.E314Q	NM_016548	NP_057632	Q8NBJ4	GOLM1_HUMAN	golgi membrane protein 1	314	Lumenal (Potential).					Golgi apparatus|integral to plasma membrane					0						CCCTCCATCTCTGGATTTTCC	0.642		NA									OREG0019278	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	131					0	0	0	0
ASTN2	23245	broad.mit.edu	37	9	119382714	119382714	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr9:119382714C>G	uc004bjs.1	-	18	3182	c.3081G>C	c.(3079-3081)AAG>AAC	p.K1027N	ASTN2_uc004bjr.1_Missense_Mutation_p.K1023N|ASTN2_uc004bjt.1_Missense_Mutation_p.K976N|ASTN2_uc004bjp.1_Missense_Mutation_p.K120N|ASTN2_uc004bjq.1_Missense_Mutation_p.K79N|ASTN2_uc011lxr.1_Missense_Mutation_p.K79N|ASTN2_uc011lxs.1_Missense_Mutation_p.K79N|ASTN2_uc011lxt.1_Missense_Mutation_p.K79N|ASTN2_uc004bjv.1_Missense_Mutation_p.K79N	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	1027	Extracellular (Potential).					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						TCAGTGCACTCTTGAAGGCCT	0.507		NA											34	150					0	0	0	0
BCOR	54880	broad.mit.edu	37	X	39923017	39923017	+	Missense_Mutation	SNP	G	G	A	rs147934033		TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chrX:39923017G>A	uc004den.3	-	8	3983	c.3691C>T	c.(3691-3693)CGG>TGG	p.R1231W	BCOR_uc004dep.3_Missense_Mutation_p.R1197W|BCOR_uc004deo.3_Missense_Mutation_p.R1179W|BCOR_uc010nhb.2_5'Flank|BCOR_uc004dem.3_Missense_Mutation_p.R1197W	NM_001123385	NP_001116857	Q6W2J9	BCOR_HUMAN	BCL-6 interacting corepressor isoform c	1231					heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4						CTGCTTTGCCGGCCAGGTTTG	0.547		NA											4	83					0	0	0	0
AWAT1	158833	broad.mit.edu	37	X	69458123	69458123	+	Silent	SNP	C	C	T			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chrX:69458123C>T	uc004dxy.2	+	5	563	c.522C>T	c.(520-522)CTC>CTT	p.L174L		NM_001013579	NP_001013597	Q58HT5	AWAT1_HUMAN	wax synthase 1	174					lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	long-chain-alcohol O-fatty-acyltransferase activity			ovary(3)	3						CTGGCAACCTCGTGGGCATTG	0.572		NA											10	31					0	0	0	0
SPANXE	171489	broad.mit.edu	37	X	140786496	140786496	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chrX:140786496C>T	uc004fbq.2	-	1	160	c.67G>A	c.(67-69)GAG>AAG	p.E23K		NM_145665	NP_663698	Q8TAD1	SPNXE_HUMAN	SPANX family, member E	23						cytoplasm|nucleus					0	Acute lymphoblastic leukemia(192;7.65e-05)					CTTACCATCTCGTTGGCCTCG	0.299		NA											26	43					0	0	0	0
UEVLD	55293	broad.mit.edu	37	11	18557990	18557992	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr11:18557990_18557992delCTT	uc001mot.2	-	10	1165_1167	c.1085_1087delAAG	c.(1084-1089)GAAGTA>GTA	p.E362del	UEVLD_uc001mou.2_In_Frame_Del_p.E362del|UEVLD_uc010rde.1_In_Frame_Del_p.E232del|UEVLD_uc010rdf.1_In_Frame_Del_p.E340del|UEVLD_uc010rdg.1_In_Frame_Del_p.E232del|UEVLD_uc001mov.2_In_Frame_Del_p.E340del	NM_001040697	NP_001035787	Q8IX04	UEVLD_HUMAN	ubiquitin-conjugating enzyme E2-like isoform a	362					cellular carbohydrate metabolic process|protein modification process|protein transport		binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor				0						TGACTCACTACTTCTTCTTGGCC	0.374		NA											20	76	---	---	---	---	NA	NA	NA	NA
IL25	64806	broad.mit.edu	37	14	23845057	23845058	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr14:23845057_23845058delTG	uc001wjr.2	+	2	812_813	c.502_503delTG	c.(502-504)TGTfs	p.C168fs	IL25_uc001wjq.2_Frame_Shift_Del_p.C152fs|CMTM5_uc001wjs.2_5'Flank|CMTM5_uc001wjt.2_5'Flank|CMTM5_uc010akm.2_5'Flank|CMTM5_uc010akn.2_5'Flank|CMTM5_uc001wju.2_5'Flank|CMTM5_uc010ako.2_5'Flank	NM_022789	NP_073626	Q9H293	IL25_HUMAN	interleukin 25 isoform 1 precursor	168					inflammatory response	extracellular space|membrane	cytokine activity|interleukin-17E receptor binding			ovary(1)	1	all_cancers(95;2e-05)			GBM - Glioblastoma multiforme(265;0.00665)|READ - Rectum adenocarcinoma(4;0.0276)|Colorectal(4;0.0396)		TTCCTTAGCTTGTGTGTGTGTG	0.604		NA											7	119	---	---	---	---	NA	NA	NA	NA
SCN2A	6326	broad.mit.edu	37	2	166170610	166170610	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CR-7385-01A-11D-2012-08	TCGA-CR-7385-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2c00b622-c4a4-4862-b14a-a97b7261f46f	bf151f1f-c716-4f9b-b159-f3958a81e2bc	g.chr2:166170610delG	uc002udc.2	+	10	1665	c.1375delG	c.(1375-1377)GAAfs	p.E459fs	SCN2A_uc002udd.2_Frame_Shift_Del_p.E459fs|SCN2A_uc002ude.2_Frame_Shift_Del_p.E459fs	NM_001040142	NP_001035232	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha	459					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)	GCAACAAGAAGAAGCTCAGGT	0.408		NA											7	31	---	---	---	---	NA	NA	NA	NA