Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
CASZ1	54897	broad.mit.edu	37	1	10713622	10713622	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:10713622G>C	uc001aro.2	-	11	2812	c.2492C>G	c.(2491-2493)TCA>TGA	p.S831*	CASZ1_uc001arp.1_Nonsense_Mutation_p.S831*|CASZ1_uc009vmx.2_Nonsense_Mutation_p.S855*	NM_001079843	NP_001073312	Q86V15	CASZ1_HUMAN	castor homolog 1, zinc finger isoform a	831					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			skin(1)	1	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		AGGGGTGGCTGAGGCTGCTGA	0.706		NA											12	52					0	0	0	0
PRAMEF11	440560	broad.mit.edu	37	1	12885059	12885059	+	Missense_Mutation	SNP	C	C	G	rs143004725	by1000genomes	TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:12885059C>G	uc001auk.2	-	4	1248	c.1052G>C	c.(1051-1053)TGC>TCC	p.C351S		NM_001146344	NP_001139816	O60813	PRA11_HUMAN	PRAME family member 11	351	LRR 6.										0						GGTGGCCATGCAGATGGGATT	0.532		NA											4	283					0	0	0	0
PDPN	10630	broad.mit.edu	37	1	13940214	13940214	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:13940214G>C	uc001avd.2	+	4	641	c.592G>C	c.(592-594)GAG>CAG	p.E198Q	PDPN_uc001avc.2_Missense_Mutation_p.E198Q|PDPN_uc009vob.2_Missense_Mutation_p.E80Q|PDPN_uc009voc.2_Missense_Mutation_p.E80Q|PDPN_uc001ave.2_Missense_Mutation_p.E80Q|PDPN_uc001avf.2_Missense_Mutation_p.E80Q	NM_006474	NP_006465	Q86YL7	PDPN_HUMAN	lung type-I cell membrane-associated	122	Extracellular (Potential).				cell morphogenesis|lymphangiogenesis|regulation of cell shape	filopodium membrane|integral to plasma membrane|lamellipodium membrane|microvillus membrane|ruffle membrane				ovary(2)	2	Ovarian(185;0.249)	all_lung(284;2.29e-05)|Lung NSC(185;4.37e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00969)|Colorectal(212;4.48e-06)|COAD - Colon adenocarcinoma(227;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000347)|Kidney(185;0.00087)|KIRC - Kidney renal clear cell carcinoma(229;0.0027)|STAD - Stomach adenocarcinoma(313;0.00802)|READ - Rectum adenocarcinoma(331;0.0678)		GACAACAGTTGAGAAAGGTAG	0.323		NA											16	19					0	0	0	0
PUM1	9698	broad.mit.edu	37	1	31423055	31423055	+	Silent	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:31423055G>A	uc001bsi.1	-	17	2888	c.2775C>T	c.(2773-2775)GTC>GTT	p.V925V	PUM1_uc001bsf.1_Silent_p.V591V|PUM1_uc001bsg.1_Silent_p.V659V|PUM1_uc001bsh.1_Silent_p.V925V|PUM1_uc001bsj.1_Silent_p.V899V|PUM1_uc010oga.1_Silent_p.V781V|PUM1_uc001bsk.1_Silent_p.V961V|PUM1_uc010ogb.1_Silent_p.V866V|SNORD103A_uc009vts.1_5'Flank	NM_014676	NP_055491	Q14671	PUM1_HUMAN	pumilio 1 isoform 2	925	PUM-HD.|Pumilio 3.				cellular membrane organization|post-Golgi vesicle-mediated transport|regulation of translation	cytosol	RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Colorectal(325;0.0211)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0381)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0232)|READ - Rectum adenocarcinoma(331;0.0681)		CCAATGACAGGACGTGGCCTC	0.438		NA											6	65					0	0	0	0
TRIT1	54802	broad.mit.edu	37	1	40319737	40319737	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:40319737C>T	uc010oiz.1	-	3	333	c.319G>A	c.(319-321)GAA>AAA	p.E107K	TRIT1_uc001cec.3_RNA|TRIT1_uc001ced.3_5'UTR|TRIT1_uc001cee.3_RNA|TRIT1_uc001cef.3_RNA|TRIT1_uc001ceg.3_5'UTR|TRIT1_uc001ceh.3_5'UTR|TRIT1_uc009vvv.2_5'UTR|TRIT1_uc001cei.3_5'UTR|TRIT1_uc001ceq.2_Intron|TRIT1_uc001cek.2_Intron|TRIT1_uc009vvx.2_Intron|TRIT1_uc001cel.2_Intron|TRIT1_uc001cem.2_Intron|TRIT1_uc001cen.2_Intron|TRIT1_uc001ceo.2_Intron|TRIT1_uc001cep.2_Intron|TRIT1_uc010oja.1_RNA	NM_017646	NP_060116	Q9H3H1	MOD5_HUMAN	tRNA isopentenyltransferase 1 precursor	107					tRNA processing	mitochondrion	ATP binding|metal ion binding|tRNA dimethylallyltransferase activity			ovary(1)	1	all_cancers(7;4.55e-14)|all_lung(5;1.23e-16)|all_epithelial(6;2.17e-16)|Lung NSC(20;7.03e-07)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;3.29e-18)|Epithelial(16;3.07e-17)|all cancers(16;6.21e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			AATATATCTTCAATGTGAACA	0.373		NA											13	73					0	0	0	0
RIMS3	9783	broad.mit.edu	37	1	41107389	41107389	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:41107389G>A	uc001cfu.1	-	3	678	c.209C>T	c.(208-210)CCG>CTG	p.P70L	RIMS3_uc001cfv.1_Missense_Mutation_p.P70L	NM_014747	NP_055562	Q9UJD0	RIMS3_HUMAN	regulating synaptic membrane exocytosis 3	70					neurotransmitter transport	cell junction|synapse					0	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.47e-17)			ACCAGGCTGCGGAAGCTGGAG	0.637		NA											15	92					0	0	0	0
SLC5A9	200010	broad.mit.edu	37	1	48708177	48708177	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:48708177G>T	uc001cro.2	+	13	1778	c.1726G>T	c.(1726-1728)GAG>TAG	p.E576*	SLC5A9_uc001crn.2_Nonsense_Mutation_p.E601*|SLC5A9_uc010omt.1_Nonsense_Mutation_p.E590*|SLC5A9_uc001crp.2_Nonsense_Mutation_p.E243*|SLC5A9_uc010omu.1_Nonsense_Mutation_p.E243*|SLC5A9_uc009vyt.1_RNA	NM_001011547	NP_001011547	Q2M3M2	SC5A9_HUMAN	solute carrier family 5 (sodium/glucose	576	Cytoplasmic (Potential).					integral to membrane|plasma membrane	low-affinity glucose:sodium symporter activity			ovary(3)	3						CTCTGAGCTGGAGAAGGAGGC	0.622		NA											6	170					0.00116845	0.00155244	1	0
ELAVL4	1996	broad.mit.edu	37	1	50661352	50661352	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:50661352G>T	uc001csb.2	+	5	896	c.628G>T	c.(628-630)GCC>TCC	p.A210S	ELAVL4_uc001cry.3_Missense_Mutation_p.A213S|ELAVL4_uc001crz.3_Missense_Mutation_p.A210S|ELAVL4_uc001csa.3_Missense_Mutation_p.A227S|ELAVL4_uc001csc.3_Missense_Mutation_p.A210S|ELAVL4_uc009vyu.2_Missense_Mutation_p.A215S|ELAVL4_uc010omz.1_Missense_Mutation_p.A215S	NM_021952	NP_068771	P26378	ELAV4_HUMAN	ELAV-like 4 isoform 1	210	RRM 2.				mRNA processing		AU-rich element binding|mRNA 3'-UTR binding|nucleotide binding			ovary(1)|pancreas(1)	2						TGTGAAGTTTGCCAACAACCC	0.572		NA											57	94					4.55e-40	7.65e-40	1	0
ORC1L	4998	broad.mit.edu	37	1	52854210	52854210	+	Silent	SNP	C	C	T	rs61756135		TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:52854210C>T	uc001ctt.2	-	8	1506	c.1287G>A	c.(1285-1287)CCG>CCA	p.P429P	ORC1L_uc010oni.1_Silent_p.P429P|ORC1L_uc001ctu.2_Silent_p.P429P|ORC1L_uc009vzd.2_Silent_p.P183P	NM_004153	NP_004144	Q13415	ORC1_HUMAN	origin recognition complex, subunit 1	429					cell cycle checkpoint|DNA-dependent DNA replication initiation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nuclear origin of replication recognition complex|nucleolus|nucleoplasm|plasma membrane	ATP binding|DNA binding|nucleoside-triphosphatase activity|protein binding				0						TTGGAAGGGGCGGTGTGGAAG	0.483		NA											8	180					0	0	0	0
FAM73A	374986	broad.mit.edu	37	1	78279429	78279429	+	Silent	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:78279429G>A	uc001dhx.2	+	6	680	c.648G>A	c.(646-648)TTG>TTA	p.L216L	FAM73A_uc010ork.1_Silent_p.L216L|FAM73A_uc010orl.1_Silent_p.L178L|FAM73A_uc001dhy.1_Silent_p.L5L	NM_198549	NP_940951	Q8NAN2	FA73A_HUMAN	hypothetical protein LOC374986	216						integral to membrane				ovary(1)	1				Colorectal(170;0.226)		GTATGGAATTGTTTGAAGAGG	0.388		NA											45	50					0	0	0	0
MCOLN3	55283	broad.mit.edu	37	1	85498622	85498622	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:85498622G>C	uc001dkp.2	-	5	661	c.568C>G	c.(568-570)CCA>GCA	p.P190A	MCOLN3_uc001dkq.2_Missense_Mutation_p.P134A|MCOLN3_uc001dkr.2_Missense_Mutation_p.P190A|MCOLN3_uc001dks.3_Missense_Mutation_p.P35A	NM_018298	NP_060768	Q8TDD5	MCLN3_HUMAN	mucolipin 3	190						integral to membrane	ion channel activity			skin(1)	1				all cancers(265;0.00957)|Epithelial(280;0.0254)		GGTTCATCTGGCTCCACAAAG	0.398		NA											110	126					0	0	0	0
CCDC18	343099	broad.mit.edu	37	1	93672782	93672782	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:93672782G>C	uc001dpq.2	+	9	1558	c.1390G>C	c.(1390-1392)GAG>CAG	p.E464Q	CCDC18_uc009wdl.1_Missense_Mutation_p.E25Q	NM_206886	NP_996769	Q5T9S5	CCD18_HUMAN	sarcoma antigen NY-SAR-41	346	Potential.									ovary(2)|breast(2)|pancreas(1)	5		all_lung(203;0.00196)|Lung NSC(277;0.00903)|Melanoma(281;0.099)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00166)|GBM - Glioblastoma multiforme(16;0.00551)|Epithelial(280;0.0967)		GCTAGAGAGTGAGTTAGAGAA	0.353		NA											7	36					0	0	0	0
AKNAD1	254268	broad.mit.edu	37	1	109369904	109369904	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:109369904T>C	uc001dwa.2	-	11	2128	c.1859A>G	c.(1858-1860)AAG>AGG	p.K620R	AKNAD1_uc010ovb.1_Missense_Mutation_p.K327R|AKNAD1_uc001dwb.2_RNA	NM_152763	NP_689976	Q5T1N1	AKND1_HUMAN	hypothetical protein LOC254268	620										ovary(3)	3						TCCGTGGCCCTTTTTCTCCAC	0.413		NA											4	219					0	0	0	0
WDR47	22911	broad.mit.edu	37	1	109538250	109538250	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:109538250G>C	uc001dwj.2	-	8	2019	c.1643C>G	c.(1642-1644)TCA>TGA	p.S548*	WDR47_uc001dwl.2_Nonsense_Mutation_p.S556*|WDR47_uc001dwi.2_Nonsense_Mutation_p.S549*|WDR47_uc001dwk.2_Nonsense_Mutation_p.S520*|WDR47_uc010ovf.1_Nonsense_Mutation_p.S475*	NM_001142551	NP_001136023	O94967	WDR47_HUMAN	WD repeat domain 47 isoform 3	548										ovary(1)	1		all_lung(203;0.00519)|all_epithelial(167;0.00611)|Lung NSC(277;0.00822)		Colorectal(144;0.0165)|Lung(183;0.0484)|COAD - Colon adenocarcinoma(174;0.128)|Epithelial(280;0.168)|all cancers(265;0.201)|LUSC - Lung squamous cell carcinoma(189;0.244)		GTGATTTGTTGATCCAGGATT	0.373		NA											37	235					0	0	0	0
PTPN22	26191	broad.mit.edu	37	1	114397643	114397643	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:114397643T>C	uc001eds.2	-	8	699	c.569A>G	c.(568-570)TAC>TGC	p.Y190C	uc001edv.1_5'Flank|PTPN22_uc009wgq.2_Missense_Mutation_p.Y190C|PTPN22_uc010owo.1_Intron|PTPN22_uc001edt.2_Intron|PTPN22_uc009wgr.2_Missense_Mutation_p.Y190C|PTPN22_uc009wgs.2_Intron|PTPN22_uc001edu.2_Missense_Mutation_p.Y190C	NM_015967	NP_057051	Q9Y2R2	PTN22_HUMAN	protein tyrosine phosphatase, non-receptor type	190	Tyrosine-protein phosphatase.				negative regulation of T cell activation|negative regulation of T cell receptor signaling pathway|phosphoanandamide dephosphorylation|regulation of B cell receptor signaling pathway|regulation of natural killer cell proliferation|T cell differentiation	internal side of plasma membrane|nucleus|perinuclear region of cytoplasm	kinase binding|protein tyrosine phosphatase activity|SH3 domain binding			kidney(2)|lung(1)|skin(1)	4	Lung SC(450;0.184)	all_cancers(81;1.93e-08)|all_epithelial(167;4.37e-08)|all_lung(203;5.22e-06)|Lung NSC(69;8.94e-06)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CCAATTCTTGTAATGAAACTG	0.299		NA											30	36					0	0	0	0
BCL9	607	broad.mit.edu	37	1	147095739	147095739	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:147095739C>G	uc001epq.2	+	10	4000	c.3260C>G	c.(3259-3261)TCT>TGT	p.S1087C	BCL9_uc010ozr.1_Missense_Mutation_p.S1001C	NM_004326	NP_004317	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	1087	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.115)					CAGCCACTTTCTCACTCCAAT	0.527		NA	T	IGH@|IGL@	B-ALL								4	468					0	0	0	0
HIST2H2BF	440689	broad.mit.edu	37	1	149783712	149783712	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:149783712G>T	uc001esr.2	-	1	217	c.167C>A	c.(166-168)TCG>TAG	p.S56*	HIST2H2BF_uc010pbj.1_Nonsense_Mutation_p.S56*|HIST2H2BF_uc010pbk.1_Nonsense_Mutation_p.S56*	NM_001024599	NP_001019770	Q5QNW6	H2B2F_HUMAN	histone cluster 2, H2bf isoform a	56					nucleosome assembly	nucleosome|nucleus	DNA binding				0	Breast(34;0.0124)|all_hematologic(923;0.127)					GGCCTTGGACGAGATGCCGGT	0.607		NA											134	313					5.71e-70	9.74e-70	1	0
HIST2H2AB	317772	broad.mit.edu	37	1	149859080	149859080	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:149859080G>T	uc001ete.2	-	1	387	c.387C>A	c.(385-387)AAC>AAA	p.N129K	HIST2H2BE_uc001etc.2_5'Flank	NM_175065	NP_778235	Q8IUE6	H2A2B_HUMAN	histone cluster 2, H2ab	129					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)|breast(1)	2	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			TTAATTACTTGTTCTTGCCAG	0.498		NA											67	86					7.59e-32	1.25e-31	1	0
RPTN	126638	broad.mit.edu	37	1	152128090	152128090	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:152128090C>G	uc001ezs.1	-	3	1550	c.1485G>C	c.(1483-1485)CAG>CAC	p.Q495H		NM_001122965	NP_001116437	Q6XPR3	RPTN_HUMAN	repetin	495	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding				0						AATGATAACTCTGGTCTTGTC	0.498		NA											6	949					0	0	0	0
FLG	2312	broad.mit.edu	37	1	152275982	152275982	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:152275982G>A	uc001ezu.1	-	3	11416	c.11380C>T	c.(11380-11382)CAG>TAG	p.Q3794*		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3794	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GACCTTCCCTGGGATGTGGTG	0.572		NA							Ichthyosis				285	564					0	0	0	0
FLG	2312	broad.mit.edu	37	1	152283008	152283008	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:152283008C>G	uc001ezu.1	-	3	4390	c.4354G>C	c.(4354-4356)GAG>CAG	p.E1452Q	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1452	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTGTGGACTCAGACTGTTCA	0.572		NA							Ichthyosis				10	608					0	0	0	0
C1orf85	112770	broad.mit.edu	37	1	156263979	156263979	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:156263979G>C	uc001foh.2	-	4	641	c.628C>G	c.(628-630)CTG>GTG	p.L210V	C1orf85_uc001fof.3_5'Flank|C1orf85_uc001fog.1_Intron|C1orf85_uc001foi.2_Missense_Mutation_p.L210V|C1orf85_uc009wrx.2_Missense_Mutation_p.L143V|C1orf85_uc001foj.2_Missense_Mutation_p.L124V	NM_144580	NP_653181	Q8WWB7	NCUG1_HUMAN	kidney predominant protein NCU-G1 precursor	210	Lumenal (Potential).				positive regulation of transcription from RNA polymerase II promoter	cytosol|integral to membrane|lysosomal membrane|nucleus	ligand-dependent nuclear receptor activity|protein binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(2)	2	Hepatocellular(266;0.158)					GCTGTGTGCAGGAGGCGAGGG	0.607		NA											15	80					0	0	0	0
CD5L	922	broad.mit.edu	37	1	157803289	157803289	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:157803289C>G	uc001frk.3	-	5	875	c.732G>C	c.(730-732)TTG>TTC	p.L244F		NM_005894	NP_005885	O43866	CD5L_HUMAN	CD5 molecule-like precursor	244	SRCR 3.				apoptosis|cellular defense response	extracellular space|membrane	scavenger receptor activity			ovary(1)	1	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			CTACTAGTCTCAAGTCAAAGG	0.478		NA											4	208					0	0	0	0
OR10X1	128367	broad.mit.edu	37	1	158549486	158549486	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:158549486G>C	uc010pin.1	-	1	204	c.204C>G	c.(202-204)GAC>GAG	p.D68E		NM_001004477	NP_001004477	Q8NGY0	O10X1_HUMAN	olfactory receptor, family 10, subfamily X,	68	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					GGAGGGACCTGTCCACCCAAG	0.478		NA											41	109					0	0	0	0
OR6K6	128371	broad.mit.edu	37	1	158725260	158725260	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:158725260G>A	uc001fsw.1	+	1	655	c.655G>A	c.(655-657)GAT>AAT	p.D219N		NM_001005184	NP_001005184	Q8NGW6	OR6K6_HUMAN	olfactory receptor, family 6, subfamily K,	219	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_hematologic(112;0.0378)					GGCCTGCACAGATACATTCCT	0.473		NA											36	104					0	0	0	0
MPZL1	9019	broad.mit.edu	37	1	167742587	167742587	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:167742587C>G	uc001geo.2	+	4	789	c.587C>G	c.(586-588)TCT>TGT	p.S196C	MPZL1_uc001gen.3_Missense_Mutation_p.S196C|MPZL1_uc001gep.2_Missense_Mutation_p.S196C|MPZL1_uc001geq.2_Intron|MPZL1_uc009wvh.2_RNA	NM_003953	NP_003944	O95297	MPZL1_HUMAN	myelin protein zero-like 1 isoform a	196	Cytoplasmic (Potential).				cell-cell signaling|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	protein binding|structural molecule activity			ovary(2)	2	all_hematologic(923;0.215)					AGGAAAAACTCTAAACGGGAT	0.438		NA											7	106					0	0	0	0
F5	2153	broad.mit.edu	37	1	169510654	169510654	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:169510654G>T	uc001ggg.1	-	13	3819	c.3674C>A	c.(3673-3675)GCC>GAC	p.A1225D		NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	1225	2-5.|35 X 9 AA approximate tandem repeats of [TNP]-L-S-P-D-L-S-Q-T.|B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	CTGACCGAGGGCTGGGGAAAG	0.532		NA											204	448					6.21e-80	1.06e-79	1	0
FAM5C	339479	broad.mit.edu	37	1	190067943	190067943	+	Silent	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:190067943C>T	uc001gse.1	-	8	1738	c.1506G>A	c.(1504-1506)CAG>CAA	p.Q502Q	FAM5C_uc010pot.1_Silent_p.Q400Q	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	502						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					TGTCCGTTTTCTGCAGCAGAT	0.498		NA											51	239					0	0	0	0
PIGR	5284	broad.mit.edu	37	1	207110641	207110641	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:207110641C>A	uc001hez.2	-	4	1028	c.844G>T	c.(844-846)GTC>TTC	p.V282F	PIGR_uc009xbz.2_Missense_Mutation_p.V282F	NM_002644	NP_002635	P01833	PIGR_HUMAN	polymeric immunoglobulin receptor precursor	282	Ig-like V-type 3.|Extracellular (Potential).					extracellular region|integral to plasma membrane	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3						GTGTTGACGACCACGTCACAG	0.602		NA											39	96					1.07e-22	1.72e-22	1	0
TRAF3IP3	80342	broad.mit.edu	37	1	209933400	209933400	+	Missense_Mutation	SNP	C	C	T	rs151094826		TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:209933400C>T	uc001hho.2	+	3	306	c.16C>T	c.(16-18)CCC>TCC	p.P6S	TRAF3IP3_uc001hhl.2_Missense_Mutation_p.P6S|TRAF3IP3_uc001hhm.1_Missense_Mutation_p.P6S|TRAF3IP3_uc001hhn.2_Missense_Mutation_p.P6S|TRAF3IP3_uc009xcr.2_Missense_Mutation_p.P6S	NM_025228	NP_079504	Q9Y228	T3JAM_HUMAN	TRAF3-interacting JNK-activating modulator	6	Cytoplasmic (Potential).					integral to membrane	protein binding			large_intestine(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.045)		CAGCCCAGACCCCAGGCCCTC	0.602		NA											18	50					0	0	0	0
USH2A	7399	broad.mit.edu	37	1	215848133	215848133	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:215848133C>T	uc001hku.1	-	63	13507	c.13120G>A	c.(13120-13122)GTA>ATA	p.V4374I		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	4374	Extracellular (Potential).|Fibronectin type-III 29.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GACCAACATACATTCATTTGA	0.488		NA								HNSCC(13;0.011)			27	61					0	0	0	0
ESRRG	2104	broad.mit.edu	37	1	216850476	216850476	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:216850476G>C	uc001hkw.1	-	2	580	c.414C>G	c.(412-414)TAC>TAG	p.Y138*	ESRRG_uc001hky.1_Nonsense_Mutation_p.Y115*|ESRRG_uc009xdp.1_Nonsense_Mutation_p.Y115*|ESRRG_uc001hkz.1_Nonsense_Mutation_p.Y115*|ESRRG_uc010puc.1_Nonsense_Mutation_p.Y115*|ESRRG_uc001hla.1_Nonsense_Mutation_p.Y115*|ESRRG_uc001hlb.1_Nonsense_Mutation_p.Y115*|ESRRG_uc010pud.1_Intron|ESRRG_uc001hlc.1_Nonsense_Mutation_p.Y115*|ESRRG_uc001hld.1_Nonsense_Mutation_p.Y115*|ESRRG_uc001hkx.1_Nonsense_Mutation_p.Y143*|ESRRG_uc009xdo.1_Nonsense_Mutation_p.Y115*|ESRRG_uc001hle.1_Nonsense_Mutation_p.Y115*	NM_001438	NP_001429	P62508	ERR3_HUMAN	estrogen-related receptor gamma isoform 1	138	Nuclear receptor.|NR C4-type.				positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	AF-2 domain binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|kidney(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0358)|all cancers(67;0.0693)|GBM - Glioblastoma multiforme(131;0.0713)	Diethylstilbestrol(DB00255)	CCCCATAGTGGTACCCAGAAG	0.498		NA											56	138					0	0	0	0
LBR	3930	broad.mit.edu	37	1	225598118	225598118	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:225598118C>A	uc001hoy.2	-	10	1332	c.1189G>T	c.(1189-1191)GTG>TTG	p.V397L	LBR_uc001hoz.2_Missense_Mutation_p.V397L|LBR_uc001hpa.1_Missense_Mutation_p.V397L	NM_002296	NP_002287	Q14739	LBR_HUMAN	lamin B receptor	397	Helical; (Potential).				cholesterol biosynthetic process	integral to nuclear inner membrane	chromo shadow domain binding|delta14-sterol reductase activity|DNA binding|lamin binding|receptor activity			ovary(1)|skin(1)	2	Breast(184;0.165)			GBM - Glioblastoma multiforme(131;0.117)		TTAATAACCACCTGAAACAAA	0.244		NA											41	83					1.47e-15	2.24e-15	1	0
C1orf55	163859	broad.mit.edu	37	1	226176001	226176001	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:226176001T>C	uc001hpu.3	-	6	783	c.730A>G	c.(730-732)ATG>GTG	p.M244V	C1orf55_uc001hpv.2_Missense_Mutation_p.M244V	NM_152608	NP_689821	Q6IQ49	CA055_HUMAN	hypothetical protein LOC163859	244										lung(1)	1	Breast(184;0.197)					TGGAAACCCATTCCTGAAGTG	0.498		NA											92	204					0	0	0	0
TTC13	79573	broad.mit.edu	37	1	231069578	231069578	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:231069578C>G	uc001huf.3	-	9	961	c.930G>C	c.(928-930)TTG>TTC	p.L310F	TTC13_uc009xfi.2_Missense_Mutation_p.L257F|TTC13_uc009xfj.2_RNA|TTC13_uc001hug.3_Missense_Mutation_p.L257F|TTC13_uc009xfk.1_Missense_Mutation_p.L200F	NM_024525	NP_078801	Q8NBP0	TTC13_HUMAN	tetratricopeptide repeat domain 13 isoform a	310	TPR 4.						binding			ovary(1)|skin(1)	2	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)		COAD - Colon adenocarcinoma(196;0.243)		CTTTCTGCTTCAAAGCTTCTT	0.328		NA											21	88					0	0	0	0
HEATR1	55127	broad.mit.edu	37	1	236724551	236724551	+	Silent	SNP	A	A	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:236724551A>G	uc001hyd.1	-	33	4745	c.4620T>C	c.(4618-4620)CCT>CCC	p.P1540P	HEATR1_uc009xgh.1_Silent_p.P702P	NM_018072	NP_060542	Q9H583	HEAT1_HUMAN	protein BAP28	1540					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			ovary(2)|skin(1)	3	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			TTAAAATCTCAGGACCACCAC	0.269		NA											3	148					0	0	0	0
RYR2	6262	broad.mit.edu	37	1	237951342	237951342	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:237951342G>T	uc001hyl.1	+	92	13503	c.13383G>T	c.(13381-13383)AAG>AAT	p.K4461N		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	4461					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GCAAACAAAAGTTGAGGCAGC	0.398		NA											13	18					9.31e-06	1.28e-05	1	0
FMN2	56776	broad.mit.edu	37	1	240256603	240256603	+	Silent	SNP	C	C	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:240256603C>A	uc010pyd.1	+	1	1419	c.1194C>A	c.(1192-1194)CCC>CCA	p.P398P	FMN2_uc010pye.1_Silent_p.P398P	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	398					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CTTCCCTGCCCGGCAGCCCCG	0.706		NA											36	76					3.04e-20	4.79e-20	1	0
FMN2	56776	broad.mit.edu	37	1	240371048	240371048	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:240371048C>A	uc010pyd.1	+	5	3161	c.2936C>A	c.(2935-2937)CCC>CAC	p.P979H	FMN2_uc010pye.1_Missense_Mutation_p.P983H	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	979	Pro-rich.|FH1.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CCTCCTCCACCCCCTCTACCC	0.716		NA											36	52					2.64e-12	3.92e-12	1	0
FMN2	56776	broad.mit.edu	37	1	240635698	240635698	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:240635698G>A	uc010pyd.1	+	17	5312	c.5087G>A	c.(5086-5088)AGA>AAA	p.R1696K	FMN2_uc010pye.1_Missense_Mutation_p.R1700K|FMN2_uc010pyg.1_Missense_Mutation_p.R292K|FMN2_uc001hyr.2_RNA	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	1696	Potential.|FH2.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			GAGGTGTGTAGACAGAAGAAA	0.328		NA											23	76					0	0	0	0
RGS7	6000	broad.mit.edu	37	1	241519074	241519074	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:241519074C>A	uc001hyv.2	-	2	333	c.3G>T	c.(1-3)ATG>ATT	p.M1I	RGS7_uc001hyu.2_Missense_Mutation_p.M1I|RGS7_uc009xgn.1_Missense_Mutation_p.M1I|RGS7_uc001hyw.2_Missense_Mutation_p.M1I	NM_002924	NP_002915	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	1					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			ovary(4)|skin(2)|kidney(1)	7		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			TCCCCTGGGCCATGTCACCCA	0.498		NA											42	91					4.67e-22	7.47e-22	1	0
OR2W5	441932	broad.mit.edu	37	1	247655015	247655015	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:247655015G>T	uc001icz.1	+	1	586	c.586G>T	c.(586-588)GAA>TAA	p.E196*		NM_001004698	NP_001004698	A6NFC9	OR2W5_HUMAN	olfactory receptor, family 2, subfamily W,	196					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|skin(1)	3	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.222)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			CATGCTGGTAGAAGCGATTCA	0.587		NA											81	146					4.42e-40	7.43e-40	1	0
OR2C3	81472	broad.mit.edu	37	1	247695641	247695641	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:247695641G>T	uc009xgy.2	-	2	535	c.173C>A	c.(172-174)ACA>AAA	p.T58K	C1orf150_uc009xgw.2_Intron|C1orf150_uc001ida.3_Intron|C1orf150_uc001idb.3_Intron|C1orf150_uc009xgx.2_Intron|LOC148824_uc001idd.2_5'Flank	NM_198074	NP_932340	Q8N628	OR2C3_HUMAN	olfactory receptor, family 2, subfamily C,	58	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0242)	OV - Ovarian serous cystadenocarcinoma(106;0.0241)			GTACATAGGTGTGTGGAGGTG	0.488		NA											53	92					1.11e-26	1.81e-26	1	0
TRIM58	25893	broad.mit.edu	37	1	248039588	248039588	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:248039588G>A	uc001ido.2	+	6	1306	c.1258G>A	c.(1258-1260)GGT>AGT	p.G420S	OR2W3_uc001idp.1_Intron	NM_015431	NP_056246	Q8NG06	TRI58_HUMAN	tripartite motif-containing 58	420	B30.2/SPRY.					intracellular	zinc ion binding			skin(3)|ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)	7	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			CTATGAAGCCGGTGAAATTTC	0.448		NA											124	220					0	0	0	0
OR2AK2	391191	broad.mit.edu	37	1	248129228	248129228	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:248129228C>A	uc010pzd.1	+	1	595	c.595C>A	c.(595-597)CTA>ATA	p.L199I	OR2L13_uc001ids.2_Intron	NM_001004491	NP_001004491	Q8NG84	O2AK2_HUMAN	olfactory receptor, family 2, subfamily AK,	199	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			AGTTCCAGCTCTACTATCATT	0.428		NA											12	114					3.07e-06	4.26e-06	1	0
OR2T4	127074	broad.mit.edu	37	1	248525904	248525904	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:248525904C>T	uc001ieh.1	+	1	1022	c.1022C>T	c.(1021-1023)CCT>CTT	p.P341L		NM_001004696	NP_001004696	Q8NH00	OR2T4_HUMAN	olfactory receptor, family 2, subfamily T,	341	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ACAGTGGAACCTGCCTTTCAA	0.393		NA											5	238					0	0	0	0
OR2T27	403239	broad.mit.edu	37	1	248813773	248813773	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:248813773C>G	uc010pzo.1	-	1	413	c.413G>C	c.(412-414)CGC>CCC	p.R138P		NM_001001824	NP_001001824	Q8NH04	O2T27_HUMAN	olfactory receptor, family 2, subfamily T,	138	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;1.15e-05)|all_epithelial(71;5.29e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.089)|Lung NSC(105;0.0969)|Melanoma(84;0.199)	all_cancers(173;0.237)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GCAGATCTTGCGGCTCATGAG	0.557		NA											50	128					0	0	0	0
GATA3	2625	broad.mit.edu	37	10	8100437	8100437	+	Silent	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr10:8100437G>A	uc001ika.2	+	3	968	c.411G>A	c.(409-411)TCG>TCA	p.S137S	GATA3_uc001ijz.2_Silent_p.S137S	NM_002051	NP_002042	P23771	GATA3_HUMAN	GATA binding protein 3 isoform 2	137	Poly-Ser.				aortic valve morphogenesis|blood coagulation|canonical Wnt receptor signaling pathway involved in metanephric kidney development|cardiac right ventricle morphogenesis|cell fate determination|cellular response to interferon-alpha|cellular response to interleukin-4|cellular response to tumor necrosis factor|defense response|ear development|lymphocyte migration|male gonad development|mesenchymal to epithelial transition|mesonephros development|negative regulation of cell cycle|negative regulation of cell motility|negative regulation of cell proliferation involved in mesonephros development|negative regulation of endothelial cell apoptosis|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation|negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation|negative regulation of inflammatory response|negative regulation of mammary gland epithelial cell proliferation|nephric duct formation|norepinephrine biosynthetic process|pharyngeal system development|phosphatidylinositol 3-kinase cascade|positive regulation of endothelial cell migration|positive regulation of interleukin-13 secretion|positive regulation of interleukin-4 production|positive regulation of interleukin-5 secretion|positive regulation of protein kinase B signaling cascade|positive regulation of T cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|positive regulation of ureteric bud formation|regulation of cellular response to X-ray|regulation of cytokine biosynthetic process|regulation of nephron tubule epithelial cell differentiation|response to estrogen stimulus|response to virus|sympathetic nervous system development|T cell receptor signaling pathway|TOR signaling cascade|ureteric bud formation|uterus development|ventricular septum development	nuclear chromatin|nucleolus|nucleoplasm	core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|E-box binding|HMG box domain binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription coactivator activity|transcription factor binding|zinc ion binding			breast(17)|ovary(3)|central_nervous_system(2)	22						CCCCGGCCTCGTCCTCCTCCT	0.716		NA	F|N|S		breast		HDR syndrome (HYPOPARATHYROIDISM|SENSORINEURAL DEAFNESS|AND RENAL DISEASE)						51	120					0	0	0	0
ACBD7	414149	broad.mit.edu	37	10	15120601	15120601	+	Silent	SNP	C	C	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr10:15120601C>A	uc001inv.2	-	4	243	c.195G>T	c.(193-195)GGG>GGT	p.G65G	ACBD7_uc010qby.1_Intron	NM_001039844	NP_001034933	Q8N6N7	ACBD7_HUMAN	acyl-Coenzyme A binding domain containing 7	65	ACB.						fatty-acyl-CoA binding				0						CCGTCGACAACCCTAGAAAGA	0.363		NA											56	115					4.48e-38	7.5e-38	1	0
NEBL	10529	broad.mit.edu	37	10	21139430	21139430	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr10:21139430A>G	uc001iqi.2	-	11	1407	c.1010T>C	c.(1009-1011)GTG>GCG	p.V337A	NEBL_uc001iqj.2_RNA|NEBL_uc001iqk.2_Intron	NM_006393	NP_006384	O76041	NEBL_HUMAN	nebulette sarcomeric isoform	337	Nebulin 9.				regulation of actin filament length		actin binding|structural constituent of muscle			ovary(2)	2						TTTATATTTCACCTTCATTGG	0.318		NA											3	117					0	0	0	0
ARHGAP21	57584	broad.mit.edu	37	10	24884718	24884718	+	Nonsense_Mutation	SNP	G	G	A	rs149363020		TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr10:24884718G>A	uc001isb.2	-	19	4127	c.3640C>T	c.(3640-3642)CGA>TGA	p.R1214*	ARHGAP21_uc010qdb.1_RNA	NM_020824	NP_065875	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	1213	Rho-GAP.				signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			ovary(7)|pancreas(1)	8						TTCAAATCTCGCCATTTCTAG	0.358		NA											27	55					0	0	0	0
YME1L1	10730	broad.mit.edu	37	10	27434503	27434503	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr10:27434503C>T	uc001iti.2	-	4	538	c.356G>A	c.(355-357)AGG>AAG	p.R119K	YME1L1_uc001itj.2_Missense_Mutation_p.R62K|YME1L1_uc010qdl.1_Missense_Mutation_p.R62K|YME1L1_uc009xkv.2_RNA|YME1L1_uc001itk.1_3'UTR	NM_139312	NP_647473	Q96TA2	YMEL1_HUMAN	YME1-like 1 isoform 1	119					protein catabolic process|proteolysis	membrane|mitochondrion	ATP binding|metal ion binding|metalloendopeptidase activity|nucleoside-triphosphatase activity			ovary(1)	1						TCCAAGGTCCCTTAAGTTAAG	0.333		NA											21	77					0	0	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37438733	37438733	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr10:37438733C>A	uc001iza.1	+	11	1532	c.1433C>A	c.(1432-1434)CCA>CAA	p.P478Q		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	534						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						AACTCTGTTCCAAATAAAGCC	0.294		NA											48	107					3.77e-23	6.06e-23	1	0
FRMPD2	143162	broad.mit.edu	37	10	49414961	49414961	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr10:49414961G>T	uc001jgi.2	-	14	1734	c.1627C>A	c.(1627-1629)CCA>ACA	p.P543T	FRMPD2_uc001jgh.2_Missense_Mutation_p.P511T|FRMPD2_uc001jgj.2_Missense_Mutation_p.P521T	NM_001018071	NP_001018081	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2 isoform 3	543	FERM.				tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			large_intestine(1)	1				Kidney(211;0.201)		CCGTATTCTGGGAGCTGCTGA	0.498		NA											21	48					5.35e-06	7.41e-06	1	0
PCDH15	65217	broad.mit.edu	37	10	55782945	55782945	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr10:55782945C>T	uc001jju.1	-	19	2628	c.2233G>A	c.(2233-2235)GAT>AAT	p.D745N	PCDH15_uc010qhq.1_Missense_Mutation_p.D750N|PCDH15_uc010qhr.1_Missense_Mutation_p.D745N|PCDH15_uc010qhs.1_Missense_Mutation_p.D757N|PCDH15_uc010qht.1_Missense_Mutation_p.D752N|PCDH15_uc010qhu.1_Missense_Mutation_p.D745N|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Missense_Mutation_p.D745N|PCDH15_uc010qhw.1_Missense_Mutation_p.D708N|PCDH15_uc010qhx.1_Missense_Mutation_p.D674N|PCDH15_uc010qhy.1_Missense_Mutation_p.D750N|PCDH15_uc010qhz.1_Missense_Mutation_p.D745N|PCDH15_uc010qia.1_Missense_Mutation_p.D723N|PCDH15_uc010qib.1_Missense_Mutation_p.D723N|PCDH15_uc001jjw.2_Missense_Mutation_p.D745N	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	745	Extracellular (Potential).|Cadherin 7.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				ATTCCAGCATCAGGGTCTGTT	0.338		NA								HNSCC(58;0.16)			9	59					0	0	0	0
RHOBTB1	9886	broad.mit.edu	37	10	62648067	62648067	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr10:62648067C>A	uc001jli.2	-	7	1797	c.1359G>T	c.(1357-1359)ATG>ATT	p.M453I	RHOBTB1_uc001jlh.2_Missense_Mutation_p.M453I|RHOBTB1_uc001jlj.2_Missense_Mutation_p.M453I|RHOBTB1_uc001jlk.2_Missense_Mutation_p.M453I|RHOBTB1_uc009xpe.1_Missense_Mutation_p.M391I|RHOBTB1_uc001jll.2_Missense_Mutation_p.M203I	NM_014836	NP_055651	O94844	RHBT1_HUMAN	Rho-related BTB domain containing 1	453					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			upper_aerodigestive_tract(1)	1	Prostate(12;0.0112)					CTTCCTTGTTCATGATGTTTT	0.483		NA											28	91					1.51e-07	2.12e-07	1	0
LRRTM3	347731	broad.mit.edu	37	10	68687192	68687192	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr10:68687192C>T	uc001jmz.1	+	2	1068	c.518C>T	c.(517-519)CCT>CTT	p.P173L	CTNNA3_uc009xpn.1_Intron|CTNNA3_uc001jmw.2_Intron|CTNNA3_uc001jmx.3_Intron|CTNNA3_uc009xpo.1_Intron|LRRTM3_uc001jmy.2_Missense_Mutation_p.P173L	NM_178011	NP_821079	Q86VH5	LRRT3_HUMAN	leucine rich repeat transmembrane neuronal 3	173	Extracellular (Potential).|LRR 5.					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						AGAACCATCCCTGTGCGAATA	0.488		NA											17	195					0	0	0	0
TET1	80312	broad.mit.edu	37	10	70406353	70406353	+	Silent	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr10:70406353G>A	uc001jok.3	+	4	4372	c.3867G>A	c.(3865-3867)ACG>ACA	p.T1289T		NM_030625	NP_085128	Q8NFU7	TET1_HUMAN	CXXC finger 6	1289					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			ovary(5)|lung(2)|prostate(1)|breast(1)	9						TACAGTTAACGGTGAATGCCA	0.458		NA											8	166					0	0	0	0
OIT3	170392	broad.mit.edu	37	10	74673213	74673213	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr10:74673213G>T	uc001jte.1	+	6	1156	c.938G>T	c.(937-939)GGT>GTT	p.G313V	OIT3_uc009xqs.1_RNA	NM_152635	NP_689848	Q8WWZ8	OIT3_HUMAN	oncoprotein-induced transcript 3 precursor	313	ZP.					nuclear envelope	calcium ion binding			ovary(2)	2	Prostate(51;0.0198)					AAGACATGTGGTACAGTGGTC	0.557		NA											39	114					1.57e-19	2.46e-19	1	0
ANXA7	310	broad.mit.edu	37	10	75139821	75139821	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr10:75139821G>A	uc001jtz.2	-	11	1196	c.1123C>T	c.(1123-1125)CAG>TAG	p.Q375*	ANXA7_uc001jua.2_Nonsense_Mutation_p.Q353*|ANXA7_uc001jub.2_Nonsense_Mutation_p.Q313*|ANXA7_uc010qki.1_Nonsense_Mutation_p.Q263*|ANXA7_uc009xre.2_Nonsense_Mutation_p.Q282*|ANXA7_uc009xrf.1_Nonsense_Mutation_p.Q295*	NM_004034	NP_004025	P20073	ANXA7_HUMAN	annexin VII isoform 2	375	Annexin 3.						calcium ion binding|calcium-dependent phospholipid binding|calcium-dependent protein binding			ovary(2)|central_nervous_system(1)	3	Prostate(51;0.0119)					GCTCTCAGCTGAGGAAAGCTT	0.428		NA											101	344					0	0	0	0
USP54	159195	broad.mit.edu	37	10	75277422	75277422	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr10:75277422G>C	uc001juo.2	-	18	2779	c.2762C>G	c.(2761-2763)TCT>TGT	p.S921C	USP54_uc010qkk.1_Missense_Mutation_p.S103C|USP54_uc001juk.2_Missense_Mutation_p.S9C|USP54_uc001jul.2_Missense_Mutation_p.S9C|USP54_uc001jum.2_RNA|USP54_uc001jun.2_RNA	NM_152586	NP_689799	Q70EL1	UBP54_HUMAN	ubiquitin specific peptidase 54	921					ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity			breast(3)|lung(2)|kidney(1)	6	Prostate(51;0.0112)					ATGGAAGAAAGAACTGGCCCC	0.512		NA											18	87					0	0	0	0
PTEN	5728	broad.mit.edu	37	10	89624270	89624270	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr10:89624270G>C	uc001kfb.2	+	2	1075	c.44G>C	c.(43-45)AGA>ACA	p.R15T	KILLIN_uc009xti.2_5'Flank	NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	15	Phosphatase tensin-type.		R -> S (in glioma).		activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.?(13)|p.0?(12)|p.R15I(4)|p.R15S(3)|p.R15K(1)|p.R14fs*26(1)|p.R15fs*28(1)|p.R15fs*9(1)|p.N12fs*6(1)|p.R14_D22del(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		AACAAAAGGAGATATCAAGAG	0.478		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			15	129					0	0	0	0
TMEM20	159371	broad.mit.edu	37	10	95658490	95658490	+	Missense_Mutation	SNP	C	C	A	rs78174634		TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr10:95658490C>A	uc001kjg.1	+	2	402	c.341C>A	c.(340-342)CCT>CAT	p.P114H	TMEM20_uc001kji.2_Intron|TMEM20_uc001kjf.1_Missense_Mutation_p.P113H|TMEM20_uc001kjh.2_Intron|TMEM20_uc010qnw.1_Missense_Mutation_p.P97H|TMEM20_uc001kjj.2_Intron	NM_001134658	NP_001128130	Q2M3R5	TMM20_HUMAN	transmembrane protein 20 isoform 1	114	Helical; (Potential).|DUF6 1.					integral to membrane				upper_aerodigestive_tract(1)	1		Colorectal(252;3.46e-05)|Renal(717;0.018)|Ovarian(717;0.0228)|all_hematologic(284;0.189)		STAD - Stomach adenocarcinoma(243;0.00345)		GTTGTTATCCCTTGCTTAATA	0.338		NA											4	47					0.000602214	0.000802385	1	0
ANO9	338440	broad.mit.edu	37	11	433389	433389	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:433389G>C	uc001lpi.2	-	4	360	c.275C>G	c.(274-276)ACT>AGT	p.T92S	ANO9_uc010qvv.1_5'UTR	NM_001012302	NP_001012302	A1A5B4	ANO9_HUMAN	tumor protein p53 inducible protein 5	92	Cytoplasmic (Potential).					chloride channel complex	chloride channel activity			central_nervous_system(2)|ovary(1)|skin(1)	4						CAGGAGGAAAGTGCGGTACAG	0.647		NA											45	40					0	0	0	0
EPS8L2	64787	broad.mit.edu	37	11	722549	722549	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:722549G>A	uc001lqt.2	+	13	1455	c.1208G>A	c.(1207-1209)CGT>CAT	p.R403H	EPS8L2_uc001lqu.2_Missense_Mutation_p.R403H|EPS8L2_uc010qwk.1_Missense_Mutation_p.R419H|EPS8L2_uc001lqv.2_Missense_Mutation_p.R358H|EPS8L2_uc001lqw.2_Missense_Mutation_p.R15H|EPS8L2_uc001lqx.2_Missense_Mutation_p.R15H|EPS8L2_uc001lqy.2_5'Flank	NM_022772	NP_073609	Q9H6S3	ES8L2_HUMAN	epidermal growth factor receptor pathway	403						cytoplasm				pancreas(1)	1		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;4.37e-27)|Epithelial(43;2.81e-26)|OV - Ovarian serous cystadenocarcinoma(40;1.33e-20)|BRCA - Breast invasive adenocarcinoma(625;4.29e-05)|Lung(200;0.0582)|LUSC - Lung squamous cell carcinoma(625;0.0703)		ATGCGGCCCCGGTAGGGCAGG	0.687		NA											24	22					0	0	0	0
OR51S1	119692	broad.mit.edu	37	11	4870420	4870420	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:4870420G>T	uc010qyo.1	-	1	19	c.19C>A	c.(19-21)CAG>AAG	p.Q7K		NM_001004758	NP_001004758	Q8NGJ8	O51S1_HUMAN	olfactory receptor, family 51, subfamily S,	7	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		GGGGCTATCTGAGTTGGTAAT	0.483		NA											50	120					9.22e-22	1.47e-21	1	0
OR52A4	390053	broad.mit.edu	37	11	5142452	5142452	+	Silent	SNP	C	C	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:5142452C>A	uc001lzz.1	-	1	357	c.357G>T	c.(355-357)CTG>CTT	p.L119L	OR52A4_uc001maa.2_RNA	NM_001005222	NP_001005222			olfactory receptor, family 52, subfamily A,											ovary(2)	2		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.7e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		CCATGGCTAGCAGGACTCCTG	0.438		NA											13	73					1.05e-09	1.53e-09	1	0
DENND5A	23258	broad.mit.edu	37	11	9161320	9161320	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:9161320G>C	uc001mhl.2	-	23	4017	c.3762C>G	c.(3760-3762)ATC>ATG	p.I1254M	DENND5A_uc001mhk.2_Missense_Mutation_p.I597M|DENND5A_uc010rbw.1_3'UTR	NM_015213	NP_056028	Q6IQ26	DEN5A_HUMAN	RAB6 interacting protein 1	1254	RUN 2.									liver(1)	1						TATGGTCTTTGATCAGTGCCA	0.527		NA											8	68					0	0	0	0
KCNJ11	3767	broad.mit.edu	37	11	17409546	17409546	+	Silent	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:17409546C>T	uc001mna.2	-	1	661	c.93G>A	c.(91-93)CGG>CGA	p.R31R	KCNJ11_uc001mnb.3_Intron	NM_000525	NP_000516	B4DWI4	B4DWI4_HUMAN	potassium inwardly-rectifying channel J11	31						integral to membrane	ATP-activated inward rectifier potassium channel activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0276)|Colorectal(2;0.0633)		AGCGGGCCCTCCGCTGGCGGG	0.652		NA											14	157					0	0	0	0
ABCC8	6833	broad.mit.edu	37	11	17427052	17427052	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:17427052T>C	uc001mnc.2	-	27	3514	c.3388A>G	c.(3388-3390)ACC>GCC	p.T1130A		NM_000352	NP_000343	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C, member 8	1130	Cytoplasmic (By similarity).|ABC transmembrane type-1 2.		T -> P (in HHF1).		carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	TGGTCGATGGTGTTACAGTCA	0.542		NA											54	191					0	0	0	0
MRGPRX2	117194	broad.mit.edu	37	11	19077336	19077336	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:19077336A>T	uc001mph.2	-	2	702	c.614T>A	c.(613-615)CTG>CAG	p.L205Q		NM_054030	NP_473371	Q96LB1	MRGX2_HUMAN	MAS-related GPR, member X2	205	Helical; Name=5; (Potential).				sensory perception of pain|sleep	plasma membrane	G-protein coupled receptor activity|neuropeptide binding			ovary(1)	1						CCTGACCAGCAGGGCCAGACT	0.547		NA											24	48					0	0	0	0
NELL1	4745	broad.mit.edu	37	11	21592462	21592462	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:21592462T>A	uc001mqe.2	+	18	2286	c.2133T>A	c.(2131-2133)CAT>CAA	p.H711Q	NELL1_uc001mqf.2_Missense_Mutation_p.H664Q|NELL1_uc009yid.2_Missense_Mutation_p.H739Q|NELL1_uc010rdo.1_Missense_Mutation_p.H654Q|NELL1_uc010rdp.1_Missense_Mutation_p.H424Q|NELL1_uc001mqh.2_Missense_Mutation_p.H256Q	NM_006157	NP_006148	Q92832	NELL1_HUMAN	nel-like 1 isoform 1 precursor	711	VWFC 4.				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			ovary(2)|large_intestine(1)	3						ATTGGACCCATAGCTGTCAGC	0.448		NA											62	168					0	0	0	0
SVIP	258010	broad.mit.edu	37	11	22848863	22848863	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:22848863C>A	uc001mqp.3	-	3	197	c.109G>T	c.(109-111)GCA>TCA	p.A37S	uc001mqq.1_5'Flank	NM_148893	NP_683691	Q8NHG7	SVIP_HUMAN	small VCP/p97-interacting protein	37						Golgi membrane|plasma membrane|smooth endoplasmic reticulum membrane					0						CCCCGAGATGCAGCCTTGAAG	0.353		NA											37	137					1.7e-12	2.53e-12	1	0
ANO3	63982	broad.mit.edu	37	11	26681844	26681844	+	Silent	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:26681844C>T	uc001mqt.3	+	27	2944	c.2799C>T	c.(2797-2799)TAC>TAT	p.Y933Y	ANO3_uc010rdr.1_Silent_p.Y917Y|ANO3_uc010rds.1_Silent_p.Y772Y|ANO3_uc010rdt.1_Silent_p.Y787Y	NM_031418	NP_113606	Q9BYT9	ANO3_HUMAN	transmembrane protein 16C	933	Helical; (Potential).					chloride channel complex	chloride channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						TCATCGCATACCTGATTCCAG	0.373		NA											27	90					0	0	0	0
SLC5A12	159963	broad.mit.edu	37	11	26742938	26742938	+	Silent	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:26742938G>A	uc001mra.2	-	1	637	c.324C>T	c.(322-324)ATC>ATT	p.I108I	SLC5A12_uc001mrb.2_Intron|SLC5A12_uc001mrc.3_Silent_p.I108I	NM_178498	NP_848593	Q1EHB4	SC5AC_HUMAN	solute carrier family 5 (sodium/glucose	108	Cytoplasmic (Potential).				sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			ovary(1)|skin(1)	2						AAGTGCTGGTGATACCAGATC	0.408		NA											20	40					0	0	0	0
CD44	960	broad.mit.edu	37	11	35222735	35222735	+	Silent	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:35222735G>A	uc001mvu.2	+	8	1463	c.1029G>A	c.(1027-1029)AGG>AGA	p.R343R	CD44_uc001mvv.2_Silent_p.R300R|CD44_uc001mvw.2_Intron|CD44_uc001mvx.2_Intron|CD44_uc001mvy.2_Intron|CD44_uc001mwc.3_Intron|CD44_uc010rer.1_Intron|CD44_uc009ykh.2_Intron|CD44_uc010res.1_Intron|CD44_uc010ret.1_Intron|CD44_uc010reu.1_Intron	NM_000610	NP_000601	P16070	CD44_HUMAN	CD44 antigen isoform 1 precursor	343	Extracellular (Potential).|Stem.				cell-cell adhesion|cell-matrix adhesion|interferon-gamma-mediated signaling pathway|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|positive regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation	cell surface|Golgi apparatus|integral to plasma membrane	collagen binding|hyaluronic acid binding|receptor activity			pancreas(1)	1	all_cancers(35;0.212)|all_lung(20;0.0874)|all_epithelial(35;0.112)	all_hematologic(20;0.107)	STAD - Stomach adenocarcinoma(6;0.00731)		Hyaluronidase(DB00070)	CAACCACAAGGATGACTGGTA	0.463		NA											41	146					0	0	0	0
OR5L2	26338	broad.mit.edu	37	11	55595390	55595390	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:55595390G>T	uc001nhy.1	+	1	696	c.696G>T	c.(694-696)GAG>GAT	p.E232D		NM_001004739	NP_001004739	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L,	232	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_epithelial(135;0.208)				ACTCTGCAGAGAGCAGGCACA	0.493		NA								HNSCC(27;0.073)			61	130					3.22e-24	5.2e-24	1	0
OR8H2	390151	broad.mit.edu	37	11	55872670	55872670	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:55872670G>T	uc010riy.1	+	1	152	c.152G>T	c.(151-153)CGC>CTC	p.R51L		NM_001005200	NP_001005200	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H,	51	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	Esophageal squamous(21;0.00693)					TTGATAATCCGCCTGGACCTC	0.428		NA								HNSCC(53;0.14)			80	277					5.43e-32	8.95e-32	1	0
OR8H2	390151	broad.mit.edu	37	11	55872803	55872803	+	Silent	SNP	G	G	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:55872803G>T	uc010riy.1	+	1	285	c.285G>T	c.(283-285)ACG>ACT	p.T95T		NM_001005200	NP_001005200	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H,	95	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	Esophageal squamous(21;0.00693)					TTTCCTTTACGGGCTGCTTTG	0.443		NA								HNSCC(53;0.14)			177	524					4.48e-97	7.66e-97	1	0
OR8K5	219453	broad.mit.edu	37	11	55927286	55927286	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:55927286C>A	uc010rja.1	-	1	508	c.508G>T	c.(508-510)GGC>TGC	p.G170C		NM_001004058	NP_001004058	Q8NH50	OR8K5_HUMAN	olfactory receptor, family 8, subfamily K,	170	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4	Esophageal squamous(21;0.00693)	Lung NSC(402;0.197)|all_epithelial(135;0.236)				ACATTAGAGCCACAGAAGGTC	0.388		NA											50	86					8.07e-11	1.19e-10	1	0
OR5M9	390162	broad.mit.edu	37	11	56230512	56230512	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:56230512C>A	uc010rjj.1	-	1	366	c.366G>T	c.(364-366)ATG>ATT	p.M122I		NM_001004743	NP_001004743	Q8NGP3	OR5M9_HUMAN	olfactory receptor, family 5, subfamily M,	122	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4	Esophageal squamous(21;0.00448)					TGCAGCCGGCCATGTACCTGT	0.493		NA											53	125					1e-16	1.54e-16	1	0
MS4A14	84689	broad.mit.edu	37	11	60183849	60183849	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:60183849G>C	uc001npj.2	+	5	1973	c.1408G>C	c.(1408-1410)GAA>CAA	p.E470Q	MS4A14_uc001npi.2_Missense_Mutation_p.E358Q|MS4A14_uc001npn.2_Missense_Mutation_p.E208Q|MS4A14_uc001npk.2_Missense_Mutation_p.E453Q|MS4A14_uc001npl.2_Missense_Mutation_p.E208Q|MS4A14_uc001npm.2_Missense_Mutation_p.E208Q	NM_032597	NP_115986	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member	470	Gln-rich.					integral to membrane	receptor activity			breast(1)	1						AGAGACCAAAGAATGGAAATC	0.388		NA											9	114					0	0	0	0
AHNAK	79026	broad.mit.edu	37	11	62295549	62295549	+	Missense_Mutation	SNP	C	C	T	rs1298288		TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:62295549C>T	uc001ntl.2	-	5	6640	c.6340G>A	c.(6340-6342)GCC>ACC	p.A2114T	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	2114					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				ATCTTGGGGGCCTTGAAGTGC	0.507		NA											7	665					0	0	0	0
FIBP	9158	broad.mit.edu	37	11	65651446	65651446	+	Silent	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:65651446C>T	uc001ogd.2	-	10	1215	c.1094G>A	c.(1093-1095)TGA>TAA	p.*365*	FIBP_uc009yqu.2_3'UTR|FIBP_uc001oge.2_Silent_p.*358*	NM_198897	NP_942600	O43427	FIBP_HUMAN	FGF intracellular binding protein isoform a	365					fibroblast growth factor receptor signaling pathway	endomembrane system|membrane|microsome|mitochondrion|nucleus	fibroblast growth factor binding			ovary(1)	1				READ - Rectum adenocarcinoma(159;0.166)		GGAGGCACCTCAGTCATGATA	0.602		NA									OREG0021089	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	77					0	0	0	0
NDUFV1	4723	broad.mit.edu	37	11	67378581	67378581	+	Silent	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:67378581C>T	uc001omj.2	+	6	969	c.816C>T	c.(814-816)GGC>GGT	p.G272G	NDUFV1_uc010rpv.1_Silent_p.G171G|NDUFV1_uc001oml.2_Silent_p.G265G|NDUFV1_uc001omk.3_Silent_p.G263G|NDUFV1_uc009yrz.1_Silent_p.G171G|NDUFV1_uc010rpw.1_5'UTR	NM_007103	NP_009034	P49821	NDUV1_HUMAN	NADH dehydrogenase ubiquinone flavoprotein 1	272					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	4 iron, 4 sulfur cluster binding|FMN binding|metal ion binding|NAD binding|NADH dehydrogenase (ubiquinone) activity			skin(1)	1					NADH(DB00157)	GCAACTCAGGCACCAAACTAT	0.542		NA											42	115					0	0	0	0
PRKRIR	5612	broad.mit.edu	37	11	76063227	76063227	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:76063227C>A	uc001oxh.1	-	5	967	c.967G>T	c.(967-969)GAG>TAG	p.E323*	PRKRIR_uc010rrz.1_Nonsense_Mutation_p.E148*	NM_004705	NP_004696	O43422	P52K_HUMAN	protein-kinase, interferon-inducible double	323					negative regulation of cell proliferation|response to stress|signal transduction		DNA binding|metal ion binding|protein dimerization activity			ovary(2)|pancreas(1)	3						CGACAATACTCCATATTTAAT	0.383		NA											41	86					9.55e-19	1.48e-18	1	0
PCF11	51585	broad.mit.edu	37	11	82879779	82879779	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:82879779G>C	uc001ozx.3	+	8	2747	c.2402G>C	c.(2401-2403)GGA>GCA	p.G801A	PCF11_uc010rsu.1_Missense_Mutation_p.G932A	NM_015885	NP_056969	O94913	PCF11_HUMAN	pre-mRNA cleavage complex II protein Pcf11	801	Gly-rich.				mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				ovary(1)	1						ATGGGGGGAGGAGGCCCTTTG	0.522		NA											7	83					0	0	0	0
DYNC2H1	79659	broad.mit.edu	37	11	103027117	103027117	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:103027117G>C	uc001pho.2	+	26	3889	c.3745G>C	c.(3745-3747)GAT>CAT	p.D1249H	DYNC2H1_uc001phn.1_Missense_Mutation_p.D1249H|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	1249	Stem (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		TGTTAAATAGGATTTAAATAG	0.284		NA											26	45					0	0	0	0
CASP1	834	broad.mit.edu	37	11	104904955	104904955	+	Missense_Mutation	SNP	C	C	T	rs2509649		TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:104904955C>T	uc010rve.1	-	2	271	c.254G>A	c.(253-255)GGG>GAG	p.G85E	CASP1_uc001pig.2_Intron|CASP1_uc001pik.2_Missense_Mutation_p.G69E|CASP1_uc010rvf.1_Intron|CASP1_uc010rvg.1_Missense_Mutation_p.G85E|CASP1_uc010rvh.1_Intron|CASP1_uc010rvi.1_Intron|CASP1_uc001pim.3_Missense_Mutation_p.G85E|CASP1_uc009yxi.2_Missense_Mutation_p.G85E|CASP1_uc010rvj.1_Missense_Mutation_p.G85E|CASP1_uc009yxj.2_5'UTR|CASP1_uc010rvk.1_Missense_Mutation_p.G46E|CASP1_uc010rvl.1_Missense_Mutation_p.G85E	NM_033292	NP_150634	P29466	CASP1_HUMAN	caspase 1 isoform alpha precursor	85	CARD.				cellular response to mechanical stimulus|cellular response to organic substance|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis|signal transduction	cytosol	caspase activator activity|cysteine-type endopeptidase activity|protein binding			ovary(2)	2		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000525)|Epithelial(105;0.0128)|all cancers(92;0.0482)	Minocycline(DB01017)|Penicillamine(DB00859)	TCCCAGCGTCCCTGCCAGGTA	0.468		NA											6	270					0	0	0	0
NPAT	4863	broad.mit.edu	37	11	108043717	108043717	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:108043717G>A	uc001pjz.3	-	13	2096	c.1994C>T	c.(1993-1995)TCT>TTT	p.S665F	NPAT_uc010rvv.1_5'Flank|NPAT_uc001pka.2_Missense_Mutation_p.S460F	NM_002519	NP_002510	Q14207	NPAT_HUMAN	nuclear protein,  ataxia-telangiectasia locus	665					positive regulation of transcription, DNA-dependent|regulation of transcription involved in G1/S phase of mitotic cell cycle	Cajal body	protein C-terminus binding|protein N-terminus binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			ovary(2)	2		all_cancers(61;2.31e-10)|all_epithelial(67;1.11e-06)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;1.05e-05)|Epithelial(105;3.01e-05)|all cancers(92;0.000816)|Colorectal(284;0.116)		TTCTTTTACAGAAGATGAAGG	0.393		NA											5	78					0	0	0	0
CBL	867	broad.mit.edu	37	11	119144609	119144609	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:119144609G>C	uc001pwe.2	+	4	760	c.622G>C	c.(622-624)GCT>CCT	p.A208P		NM_005188	NP_005179	P22681	CBL_HUMAN	Cas-Br-M (murine) ecotropic retroviral	208	Cbl-PTB.|EF-hand-like.				epidermal growth factor receptor signaling pathway|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of receptor-mediated endocytosis	cytosol|nucleus	calcium ion binding|sequence-specific DNA binding transcription factor activity|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(135)|lung(10)|central_nervous_system(2)|ovary(1)|breast(1)	149		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.92e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.000784)		CTTTCGACAGGCTCTACATGA	0.458		NA							CBL_gene-associated_Juvenile_Myelomonocytic_Leukemia_and_Developmental_Anomalies|Noonan_syndrome				24	56					0	0	0	0
TBCEL	219899	broad.mit.edu	37	11	120925915	120925915	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:120925915A>T	uc009zay.2	+	5	688	c.610A>T	c.(610-612)ACC>TCC	p.T204S	TBCEL_uc001pxo.2_Missense_Mutation_p.T204S|TBCEL_uc001pxp.2_Missense_Mutation_p.T60S|TBCEL_uc001pxq.2_Intron	NM_001130047	NP_001123519	Q5QJ74	TBCEL_HUMAN	tubulin folding cofactor E-like	204	LRR 6.					cytoplasm|cytoskeleton				skin(1)	1		Breast(109;0.00526)|Medulloblastoma(222;0.0523)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;5.89e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.121)		TTCACTGGATACCCTCGTCCT	0.418		NA											40	63					0	0	0	0
SORL1	6653	broad.mit.edu	37	11	121476228	121476228	+	Silent	SNP	C	C	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:121476228C>G	uc001pxx.2	+	35	4976	c.4896C>G	c.(4894-4896)CTC>CTG	p.L1632L	SORL1_uc010rzp.1_Silent_p.L478L|SORL1_uc010rzq.1_Silent_p.L247L	NM_003105	NP_003096	Q92673	SORL_HUMAN	sortilin-related receptor containing LDLR class	1632	Extracellular (Potential).|Fibronectin type-III 1.				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			ovary(5)|breast(4)|large_intestine(2)|skin(2)|central_nervous_system(1)|pancreas(1)	15		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		TTCAGTGTCTCAGCAAGGCAC	0.443		NA											29	357					0	0	0	0
C12orf60	144608	broad.mit.edu	37	12	14976373	14976373	+	Silent	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr12:14976373C>T	uc001rcj.3	+	2	708	c.504C>T	c.(502-504)ACC>ACT	p.T168T		NM_175874	NP_787070	Q5U649	CL060_HUMAN	hypothetical protein LOC144608	168										ovary(1)|central_nervous_system(1)	2						CAGATGTCACCACATCTGAGA	0.393		NA											6	77					0	0	0	0
SCN8A	6334	broad.mit.edu	37	12	52139700	52139700	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr12:52139700T>G	uc001ryw.2	+	13	2190	c.2012T>G	c.(2011-2013)GTG>GGG	p.V671G	SCN8A_uc010snl.1_Missense_Mutation_p.V536G|SCN8A_uc001ryx.1_Missense_Mutation_p.V547G|SCN8A_uc001ryz.1_Missense_Mutation_p.V547G|SCN8A_uc001ryy.2_Missense_Mutation_p.V536G	NM_014191	NP_055006	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha	671					axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			ovary(7)	7				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	ACAACTGAGGTGGAAATTAAG	0.388		NA											8	65					0	0	0	0
SUOX	6821	broad.mit.edu	37	12	56396425	56396425	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr12:56396425C>G	uc001six.2	+	5	475	c.149C>G	c.(148-150)TCC>TGC	p.S50C	SUOX_uc009zoh.2_Missense_Mutation_p.S50C|SUOX_uc001siy.2_Missense_Mutation_p.S50C|SUOX_uc001siz.2_Missense_Mutation_p.S50C|SUOX_uc001sja.2_Missense_Mutation_p.S50C	NM_000456	NP_000447	P51687	SUOX_HUMAN	sulfite oxidase precursor	50						mitochondrial intermembrane space	electron carrier activity|molybdenum ion binding|sulfite oxidase activity				0			UCEC - Uterine corpus endometrioid carcinoma (6;0.0471)|OV - Ovarian serous cystadenocarcinoma(18;0.119)			GGTGATAACTCCAGCACCCAG	0.537		NA											39	201					0	0	0	0
SMARCC2	6601	broad.mit.edu	37	12	56572300	56572300	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr12:56572300T>C	uc001skb.2	-	14	1304	c.1198A>G	c.(1198-1200)ACG>GCG	p.T400A	SMARCC2_uc001skd.2_Missense_Mutation_p.T400A|SMARCC2_uc001ska.2_Missense_Mutation_p.T400A|SMARCC2_uc001skc.2_Missense_Mutation_p.T400A|SMARCC2_uc010sqf.1_Missense_Mutation_p.T289A	NM_003075	NP_003066	Q8TAQ2	SMRC2_HUMAN	SWI/SNF-related matrix-associated	400					chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			lung(2)|central_nervous_system(2)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(18;0.123)			TTGTTCCCCGTACTGTTCTCA	0.542		NA											5	145					0	0	0	0
MARS	4141	broad.mit.edu	37	12	57883081	57883081	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr12:57883081G>A	uc001sog.2	+	3	255	c.232G>A	c.(232-234)GAT>AAT	p.D78N	ARHGAP9_uc001sod.2_5'Flank|ARHGAP9_uc001soe.1_5'Flank|MARS_uc001sof.1_RNA|MARS_uc010srp.1_Intron|MARS_uc010srq.1_5'UTR	NM_004990	NP_004981	P56192	SYMC_HUMAN	methionyl-tRNA synthetase	78	GST C-terminal.				methionyl-tRNA aminoacylation	cytosol	ATP binding|methionine-tRNA ligase activity|protein binding|tRNA binding			ovary(3)|central_nervous_system(1)|pancreas(1)	5			GBM - Glioblastoma multiforme(3;4.27e-41)		L-Methionine(DB00134)	CTGGGAGCAAGATGACCTCAC	0.517		NA											11	158					0	0	0	0
NUP107	57122	broad.mit.edu	37	12	69109407	69109407	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr12:69109407G>T	uc001suf.2	+	12	1085	c.970G>T	c.(970-972)GAC>TAC	p.D324Y	NUP107_uc001sug.2_Missense_Mutation_p.D171Y|NUP107_uc010stj.1_Missense_Mutation_p.D295Y	NM_020401	NP_065134	P57740	NU107_HUMAN	nucleoporin 107kDa	324					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			skin(1)	1	Breast(13;6.25e-06)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00694)			CTTCTTACAGGACCCTGATGC	0.358		NA											49	109					2.08e-19	3.26e-19	1	0
TBC1D15	64786	broad.mit.edu	37	12	72278770	72278770	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr12:72278770G>T	uc001swu.2	+	5	598	c.589G>T	c.(589-591)GAA>TAA	p.E197*	TBC1D15_uc009zrv.2_Nonsense_Mutation_p.E76*|TBC1D15_uc010stt.1_Nonsense_Mutation_p.E183*|TBC1D15_uc001swv.2_Nonsense_Mutation_p.E197*|TBC1D15_uc001sww.2_Intron	NM_022771	NP_073608	Q8TC07	TBC15_HUMAN	TBC1 domain family, member 15 isoform 1	175							protein binding|Rab GTPase activator activity				0						ACTACTGATTGAATCTCTTGA	0.353		NA											15	77					2.32e-05	3.17e-05	1	0
NAV3	89795	broad.mit.edu	37	12	78444768	78444768	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr12:78444768G>A	uc001syp.2	+	11	2530	c.2357G>A	c.(2356-2358)CGT>CAT	p.R786H	NAV3_uc001syo.2_Missense_Mutation_p.R786H|NAV3_uc010sub.1_Missense_Mutation_p.R286H	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	786						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						ACGCCTCTCCGTCGAGCTGCT	0.557		NA								HNSCC(70;0.22)			17	40					0	0	0	0
CCDC41	51134	broad.mit.edu	37	12	94806149	94806149	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr12:94806149A>T	uc001tdd.2	-	3	704	c.118T>A	c.(118-120)TTA>ATA	p.L40I	CCDC41_uc001tde.2_Missense_Mutation_p.L40I|CCDC41_uc009zsw.1_RNA|CCDC41_uc001tdf.2_Missense_Mutation_p.L40I	NM_016122	NP_057206	Q9Y592	CCD41_HUMAN	NY-REN-58 antigen	32	Potential.										0						TCACATCGTAACCTTTCATCA	0.378		NA											32	116					0	0	0	0
UTP20	27340	broad.mit.edu	37	12	101750774	101750774	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr12:101750774C>G	uc001tia.1	+	43	5761	c.5605C>G	c.(5605-5607)CTT>GTT	p.L1869V		NM_014503	NP_055318	O75691	UTP20_HUMAN	down-regulated in metastasis	1869	HEAT 2.				endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			ovary(2)|breast(2)	4						ACGCAGCACTCTTGCGAAAAT	0.388		NA											28	48					0	0	0	0
RFX4	5992	broad.mit.edu	37	12	107109319	107109319	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr12:107109319C>T	uc001tlr.2	+	11	1201	c.1135C>T	c.(1135-1137)CAA>TAA	p.Q379*	RFX4_uc010swv.1_RNA|RFX4_uc001tls.2_Nonsense_Mutation_p.Q388*|RFX4_uc001tlt.2_Nonsense_Mutation_p.Q388*|RFX4_uc001tlv.2_Nonsense_Mutation_p.Q285*	NM_213594	NP_998759	Q33E94	RFX4_HUMAN	regulatory factor X4 isoform c	379	Necessary for dimerization.				transcription, DNA-dependent	nucleus	DNA binding			upper_aerodigestive_tract(1)	1						ACTCATCACCCAATGTAAGCT	0.458		NA											49	96					0	0	0	0
KCTD10	83892	broad.mit.edu	37	12	109893929	109893929	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr12:109893929C>A	uc001toi.1	-	6	805	c.717G>T	c.(715-717)CAG>CAT	p.Q239H	KCTD10_uc001toh.1_RNA|KCTD10_uc009zvi.1_Missense_Mutation_p.Q213H|KCTD10_uc001toj.1_Missense_Mutation_p.Q248H|KCTD10_uc001tok.1_Missense_Mutation_p.Q58H	NM_031954	NP_114160	Q9H3F6	BACD3_HUMAN	potassium channel tetramerisation domain	239	PCNA-binding (By similarity).				proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination	Cul3-RING ubiquitin ligase complex|cytoplasm|nucleus|voltage-gated potassium channel complex	voltage-gated potassium channel activity				0						TTACCTTGGTCTGTTTCTTCT	0.473		NA											25	62					4.78e-09	6.88e-09	1	0
C12orf51	283450	broad.mit.edu	37	12	112711557	112711557	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr12:112711557G>C	uc009zwc.2	-	4	566	c.548C>G	c.(547-549)TCA>TGA	p.S183*	C12orf51_uc010syk.1_Nonsense_Mutation_p.S6*|C12orf51_uc001tts.2_Nonsense_Mutation_p.S6*|C12orf51_uc001ttt.3_Nonsense_Mutation_p.S6*	NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						ATAGTCATTTGAGCATGTCCA	0.443		NA											9	167					0	0	0	0
HPD	3242	broad.mit.edu	37	12	122281718	122281718	+	Silent	SNP	T	T	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr12:122281718T>C	uc001ubj.2	-	12	892	c.852A>G	c.(850-852)AGA>AGG	p.R284R	HPD_uc001ubk.2_Silent_p.R245R	NM_002150	NP_002141	P32754	HPPD_HUMAN	4-hydroxyphenylpyruvate dioxygenase	284					L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	4-hydroxyphenylpyruvate dioxygenase activity|metal ion binding				0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000105)|Epithelial(86;0.000352)|BRCA - Breast invasive adenocarcinoma(302;0.225)	Nitisinone(DB00348)	ACTCCAGGCCTCTCTCTCTCA	0.537		NA											3	93					0	0	0	0
MPHOSPH9	10198	broad.mit.edu	37	12	123651318	123651318	+	Silent	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr12:123651318G>A	uc001uel.2	-	13	2126	c.2019C>T	c.(2017-2019)GAC>GAT	p.D673D	MPHOSPH9_uc010tal.1_Silent_p.D127D|MPHOSPH9_uc010tam.1_RNA|MPHOSPH9_uc001uem.2_Silent_p.D127D	NM_022782	NP_073619	Q99550	MPP9_HUMAN	M-phase phosphoprotein 9	673					M phase of mitotic cell cycle	centriole|Golgi membrane					0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000182)|Epithelial(86;0.00046)|BRCA - Breast invasive adenocarcinoma(302;0.169)		GCCTGCTGACGTCTGAAGTTG	0.473		NA											73	146					0	0	0	0
DNAH10	196385	broad.mit.edu	37	12	124408924	124408924	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr12:124408924A>G	uc001uft.3	+	66	11382	c.11357A>G	c.(11356-11358)GAC>GGC	p.D3786G	DNAH10_uc001ufu.3_5'Flank	NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	3786					microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		ATGTTTTCAGACAACTTTGGG	0.453		NA											14	38					0	0	0	0
UBC	7316	broad.mit.edu	37	12	125397588	125397588	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr12:125397588C>G	uc001ugs.3	-	2	1178	c.730G>C	c.(730-732)GAG>CAG	p.E244Q	UBC_uc001ugr.2_5'Flank|UBC_uc001ugu.1_Missense_Mutation_p.E244Q|UBC_uc001ugt.2_Missense_Mutation_p.E244Q|UBC_uc001ugv.2_Intron|UBC_uc001ugw.2_Missense_Mutation_p.E92Q	NM_021009	NP_066289	P0CG48	UBC_HUMAN	ubiquitin C	244	Ubiquitin-like 4.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.17e-05)|Epithelial(86;0.000207)|all cancers(50;0.00308)		GGCTCGACCTCAAGGGTGATG	0.512		NA											21	330					0	0	0	0
ATP12A	479	broad.mit.edu	37	13	25263504	25263504	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr13:25263504G>C	uc001upp.2	+	5	724	c.537G>C	c.(535-537)ATG>ATC	p.M179I	ATP12A_uc010aaa.2_Missense_Mutation_p.M179I	NM_001676	NP_001667	P54707	AT12A_HUMAN	hydrogen/potassium-exchanging ATPase 12A	179	Cytoplasmic (Potential).				ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			ovary(2)|central_nervous_system(2)|large_intestine(1)|breast(1)	6		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	TCAATAAGATGATCCCTCAGG	0.552		NA											20	124					0	0	0	0
MTUS2	23281	broad.mit.edu	37	13	29599738	29599738	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr13:29599738A>T	uc001usl.3	+	1	991	c.933A>T	c.(931-933)TTA>TTT	p.L311F		NM_001033602	NP_001028774	Q5JR59	MTUS2_HUMAN	hypothetical protein LOC23281 isoform a	301						cytoplasm|microtubule	microtubule binding|protein homodimerization activity				0						AAGCACAATTAGGTCAGGGAA	0.517		NA											19	24					0	0	0	0
N4BP2L2	10443	broad.mit.edu	37	13	33016826	33016826	+	Silent	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr13:33016826C>T	uc010abe.1	-	7	1870	c.1848G>A	c.(1846-1848)CTG>CTA	p.L616L	N4BP2L2_uc001uug.2_Silent_p.L499L|N4BP2L2_uc010abd.1_Silent_p.L529L|N4BP2L2_uc001uuh.2_Silent_p.L447L|N4BP2L2_uc001uuj.2_Intron|N4BP2L2_uc010tdz.1_Silent_p.L601L	NM_033111	NP_149102	Q92802	N42L2_HUMAN	phosphonoformate immuno-associated protein 5	Error:Variant_position_missing_in_Q92802_after_alignment											0		Lung SC(185;0.0262)		all cancers(112;9.5e-07)|Epithelial(112;5.07e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00196)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.243)		AAGTCAAAAACAGTTTCTTGT	0.323		NA											25	30					0	0	0	0
PDS5B	23047	broad.mit.edu	37	13	33281144	33281144	+	Missense_Mutation	SNP	C	C	G	rs141013786	by1000genomes	TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr13:33281144C>G	uc010abf.2	+	18	2088	c.1930C>G	c.(1930-1932)CAA>GAA	p.Q644E	PDS5B_uc010abg.2_RNA	NM_015032	NP_055847	Q9NTI5	PDS5B_HUMAN	PDS5, regulator of cohesion maintenance, homolog	644					cell division|cell proliferation|mitotic sister chromatid cohesion|negative regulation of cell proliferation	chromatin|nucleus	ATP binding|DNA binding|identical protein binding			ovary(2)|lung(1)|pancreas(1)	4		Lung SC(185;0.0367)		all cancers(112;5.55e-06)|Epithelial(112;2.7e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00303)|BRCA - Breast invasive adenocarcinoma(63;0.0204)		TCCAACTGATCAAGCCATCAG	0.313		NA											12	73					0	0	0	0
STOML3	161003	broad.mit.edu	37	13	39564848	39564848	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr13:39564848C>A	uc001uwx.2	-	1	149	c.11G>T	c.(10-12)AGG>ATG	p.R4M	STOML3_uc010tez.1_Translation_Start_Site	NM_145286	NP_660329	Q8TAV4	STML3_HUMAN	stomatin-like 3 isoform 1	4						integral to membrane|plasma membrane				ovary(1)	1		Lung NSC(96;1.42e-05)|Prostate(109;0.00851)|Breast(139;0.0199)|Lung SC(185;0.0743)		all cancers(112;2.93e-08)|Epithelial(112;3.64e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00107)|BRCA - Breast invasive adenocarcinoma(63;0.00349)|GBM - Glioblastoma multiforme(144;0.0137)		TGAAGACACCCTAGAATCCAT	0.408		NA											10	98					0.000219431	0.000296274	1	0
RB1	5925	broad.mit.edu	37	13	48955580	48955580	+	Splice_Site	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr13:48955580G>A	uc001vcb.2	+	17	1861	c.1695_splice	c.e17+1	p.S565_splice		NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1						androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(4)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	ATGGCTCTCAGTAAGTAGCTA	0.343		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			13	15					0	0	0	0
CYSLTR2	57105	broad.mit.edu	37	13	49281892	49281893	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr13:49281892_49281893GG>TT	uc010acx.1	+	6	1622_1623	c.939_940GG>TT	c.(937-942)AAGGAC>AATTAC	p.313_314KD>NY	CYSLTR2_uc010acy.1_Missense_Mutation_p.313_314KD>NY|CYSLTR2_uc010acz.1_Missense_Mutation_p.313_314KD>NY|CYSLTR2_uc010ada.1_Missense_Mutation_p.313_314KD>NY|CYSLTR2_uc010adb.1_Missense_Mutation_p.313_314KD>NY|CYSLTR2_uc010adc.1_Missense_Mutation_p.313_314KD>NY|CYSLTR2_uc010add.1_Missense_Mutation_p.313_314KD>NY|CYSLTR2_uc010acw.1_Missense_Mutation_p.313_314KD>NY|CYSLTR2_uc001vck.2_Missense_Mutation_p.313_314KD>NY	NM_020377	NP_065110	Q9NS75	CLTR2_HUMAN	cysteinyl leukotriene receptor 2	313_314	Cytoplasmic (Potential).				immune response	integral to membrane|plasma membrane				lung(2)	2		all_cancers(8;1.66e-53)|all_epithelial(8;1.96e-19)|all_lung(13;9.94e-09)|all_hematologic(8;7.13e-07)|Lung NSC(96;1.72e-06)|Breast(56;1.53e-05)|Acute lymphoblastic leukemia(8;6.86e-05)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0416)|Lung SC(185;0.0787)		GBM - Glioblastoma multiforme(99;1.19e-09)	Nedocromil(DB00716)	AGAATTTTAAGGACAGACTAAA	0.441		NA											55	50					0	0	0	0
PCCA	5095	broad.mit.edu	37	13	100807338	100807338	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr13:100807338G>T	uc001voo.2	+	5	444	c.406G>T	c.(406-408)GCC>TCC	p.A136S	PCCA_uc010aga.2_Missense_Mutation_p.A110S|PCCA_uc010tiz.1_Missense_Mutation_p.A136S	NM_000282	NP_000273	P05165	PCCA_HUMAN	propionyl-Coenzyme A carboxylase, alpha	136	Biotin carboxylation.				fatty acid beta-oxidation	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|enzyme binding|metal ion binding|propionyl-CoA carboxylase activity			skin(2)	2	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Biotin(DB00121)	GAAAACCAGGGCCCAAGCTGT	0.423		NA											103	52					7.35e-47	1.24e-46	1	0
POTEG	404785	broad.mit.edu	37	14	19553818	19553818	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr14:19553818C>G	uc001vuz.1	+	1	454	c.402C>G	c.(400-402)CAC>CAG	p.H134Q	POTEG_uc001vva.1_RNA|POTEG_uc010ahc.1_RNA	NM_001005356	NP_001005356	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	134										ovary(1)	1						CGAGGTACCACGTCCGTCGAG	0.587		NA											23	458					0	0	0	0
FOXG1	2290	broad.mit.edu	37	14	29237608	29237608	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr14:29237608G>T	uc001wqe.2	+	1	1322	c.1123G>T	c.(1123-1125)GCC>TCC	p.A375S		NM_005249	NP_005240	P55316	FOXG1_HUMAN	forkhead box G1	375					axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)|lung(2)	4			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)		GATCCCGTACGCCACGCACCA	0.677		NA											40	88					2.76e-19	4.3e-19	1	0
FOXA1	3169	broad.mit.edu	37	14	38060620	38060620	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr14:38060620G>A	uc001wuf.2	-	2	1681	c.1369C>T	c.(1369-1371)CCG>TCG	p.P457S	FOXA1_uc010tpz.1_Missense_Mutation_p.P424S	NM_004496	NP_004487	P55317	FOXA1_HUMAN	forkhead box A1	457					chromatin remodeling|embryo development|epithelial cell maturation involved in prostate gland development|epithelial tube branching involved in lung morphogenesis|epithelial-mesenchymal signaling involved in prostate gland development|glucose homeostasis|lung epithelial cell differentiation|negative regulation of survival gene product expression|neuron fate specification|pattern specification process|positive regulation of estrogen receptor signaling pathway|positive regulation of mitotic cell cycle|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|prostate gland epithelium morphogenesis|prostate gland stromal morphogenesis|response to estradiol stimulus|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding				0	Breast(36;0.0954)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;5.41e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.0454)|LUSC - Lung squamous cell carcinoma(13;0.0917)|all cancers(34;0.0925)|BRCA - Breast invasive adenocarcinoma(188;0.239)	GBM - Glioblastoma multiforme(112;0.0222)		TAGTACGCCGGCTCCAGGGCT	0.612		NA											4	103					0	0	0	0
SLC35F4	341880	broad.mit.edu	37	14	58060786	58060786	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr14:58060786G>A	uc001xdb.1	-	2	268	c.268C>T	c.(268-270)CAC>TAC	p.H90Y	SLC35F4_uc010aoz.1_RNA|SLC35F4_uc010apa.1_5'UTR	NM_001080455	NP_001073924			solute carrier family 35, member F4											ovary(2)	2						ATGCCACTGTGTGAACTGGGG	0.488		NA											18	27					0	0	0	0
SYT16	83851	broad.mit.edu	37	14	62550913	62550913	+	Splice_Site	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr14:62550913G>A	uc001xfu.1	+	5	1632	c.1435_splice	c.e5-1	p.S479_splice	SYT16_uc010tse.1_Splice_Site_p.S37_splice	NM_031914	NP_114120	Q17RD7	SYT16_HUMAN	synaptotagmin XIV-like											central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.0438)|BRCA - Breast invasive adenocarcinoma(234;0.118)		TTCCCCTCCAGAGTGGAGGGT	0.522		NA											42	148					0	0	0	0
ZBTB25	7597	broad.mit.edu	37	14	64954378	64954378	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr14:64954378G>A	uc001xhf.2	-	3	754	c.571C>T	c.(571-573)CAG>TAG	p.Q191*	ZBTB25_uc001xhc.2_Intron|ZBTB25_uc001xhg.2_Nonsense_Mutation_p.Q191*	NM_006977	NP_008908	P24278	ZBT25_HUMAN	zinc finger protein 46	191						cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2				all cancers(60;0.00865)|OV - Ovarian serous cystadenocarcinoma(108;0.0102)|BRCA - Breast invasive adenocarcinoma(234;0.0469)		TCCAGGGCCTGGGTGGCAGGA	0.592		NA											141	286					0	0	0	0
PLEKHH1	57475	broad.mit.edu	37	14	68029252	68029252	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr14:68029252A>T	uc001xjl.1	+	7	1046	c.904A>T	c.(904-906)AGG>TGG	p.R302W		NM_020715	NP_065766	Q9ULM0	PKHH1_HUMAN	pleckstrin homology domain containing, family H	302						cytoskeleton	binding				0				all cancers(60;0.000771)|OV - Ovarian serous cystadenocarcinoma(108;0.00502)|BRCA - Breast invasive adenocarcinoma(234;0.011)		GACCTCTGCCAGGGAAGGTGG	0.592		NA											15	49					0	0	0	0
SLC39A9	55334	broad.mit.edu	37	14	69919976	69919976	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr14:69919976C>G	uc001xle.2	+	4	1102	c.422C>G	c.(421-423)TCT>TGT	p.S141C	SLC39A9_uc010aqx.2_Intron|SLC39A9_uc001xlf.3_Missense_Mutation_p.S141C|SLC39A9_uc001xlg.3_RNA	NM_018375	NP_060845	Q9NUM3	S39A9_HUMAN	solute carrier family 39 (zinc transporter),	141					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity				0				all cancers(60;0.00299)|BRCA - Breast invasive adenocarcinoma(234;0.0145)|OV - Ovarian serous cystadenocarcinoma(108;0.0373)		GCAGCAAGGTCTAGCAATTCC	0.448		NA											7	199					0	0	0	0
FLRT2	23768	broad.mit.edu	37	14	86088200	86088200	+	Silent	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr14:86088200C>T	uc001xvr.2	+	2	1109	c.342C>T	c.(340-342)CTC>CTT	p.L114L	FLRT2_uc010atd.2_Silent_p.L114L	NM_013231	NP_037363	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	114	LRR 3.|Extracellular (Potential).				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			ovary(3)|haematopoietic_and_lymphoid_tissue(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.0319)		TCAGAGTTCTCCATTTGCAGG	0.493		NA											61	133					0	0	0	0
PTPN21	11099	broad.mit.edu	37	14	88983571	88983571	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr14:88983571T>G	uc001xwv.3	-	3	546	c.215A>C	c.(214-216)CAA>CCA	p.Q72P	PTPN21_uc010twc.1_5'UTR|PTPN21_uc010atf.1_Missense_Mutation_p.Q72P	NM_007039	NP_008970	Q16825	PTN21_HUMAN	protein tyrosine phosphatase, non-receptor type	72	FERM.					cytoplasm|cytoskeleton	binding|protein tyrosine phosphatase activity			ovary(3)|skin(1)	4						GCGCTGATTTTGCTTGTTGTA	0.423		NA											50	112					0	0	0	0
CPSF2	53981	broad.mit.edu	37	14	92625450	92625450	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr14:92625450G>T	uc001yah.1	+	14	2182	c.1945G>T	c.(1945-1947)GAA>TAA	p.E649*		NM_017437	NP_059133	Q9P2I0	CPSF2_HUMAN	cleavage and polyadenylation specific factor 2	649					histone mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	hydrolase activity|protein binding|RNA binding			ovary(2)	2		all_cancers(154;0.0766)		COAD - Colon adenocarcinoma(157;0.222)		GGTTATTTTAGAAGAAGGAGA	0.413		NA											31	62					6.04e-23	9.69e-23	1	0
RCOR1	23186	broad.mit.edu	37	14	103188673	103188673	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr14:103188673G>C	uc001ymb.2	+	11	1330	c.1330G>C	c.(1330-1332)GAA>CAA	p.E444Q		NM_015156	NP_055971	Q9UKL0	RCOR1_HUMAN	REST corepressor 1	444					blood coagulation|histone H4 deacetylation|interspecies interaction between organisms	transcriptional repressor complex	protein binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription regulatory region DNA binding			ovary(1)	1						ACATGGTAAAGAAGAGACCAA	0.413		NA											21	277					0	0	0	0
GJD2	57369	broad.mit.edu	37	15	35045073	35045073	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr15:35045073C>A	uc001zis.1	-	2	572	c.572G>T	c.(571-573)AGG>ATG	p.R191M	uc001zit.1_5'Flank	NM_020660	NP_065711	Q9UKL4	CXD2_HUMAN	gap junction protein, delta 2, 36kDa	191	Cytoplasmic (Potential).				synaptic transmission	connexon complex|integral to membrane	gap junction channel activity				0		all_lung(180;9.67e-07)		all cancers(64;2.75e-18)|GBM - Glioblastoma multiforme(113;1.9e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0156)		GCCTTCCTGCCTTCTGAGCTT	0.478		NA											91	142					2.06e-34	3.43e-34	1	0
BUB1B	701	broad.mit.edu	37	15	40462766	40462766	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr15:40462766C>T	uc001zkx.3	+	4	480	c.268C>T	c.(268-270)CCT>TCT	p.P90S		NM_001211	NP_001202	O60566	BUB1B_HUMAN	budding uninhibited by benzimidazoles 1 beta	90	BUB1 N-terminal.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell division|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|phosphatidylinositol-mediated signaling|protein localization to kinetochore|spindle organization	anaphase-promoting complex|condensed chromosome outer kinetochore|cytosol|microtubule organizing center|perinuclear region of cytoplasm|spindle midzone	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)|kidney(1)	4		all_cancers(109;1.12e-18)|all_epithelial(112;1.61e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.83e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0556)		GCAGAACTATCCTCAAGGTGG	0.373		NA	Mis|N|F|S			rhabdomyosarcoma			Mosaic_Variegated_Aneuploidy_Syndrome				10	104					0	0	0	0
GANC	2595	broad.mit.edu	37	15	42632035	42632035	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr15:42632035G>T	uc001zpi.2	+	17	2326	c.2012G>T	c.(2011-2013)AGA>ATA	p.R671I		NM_198141	NP_937784	Q8TET4	GANC_HUMAN	glucosidase, alpha; neutral C	671					carbohydrate metabolic process		carbohydrate binding|maltose alpha-glucosidase activity			central_nervous_system(2)	2		all_cancers(109;3.08e-16)|all_epithelial(112;7.48e-15)|Lung NSC(122;3.08e-09)|all_lung(180;1.48e-08)|Melanoma(134;0.0574)|Colorectal(260;0.153)		GBM - Glioblastoma multiforme(94;1.06e-06)		GAAGCCATCAGAGAGCGCTAT	0.542		NA											40	75					7.53e-24	1.22e-23	1	0
SLC12A1	6557	broad.mit.edu	37	15	48577394	48577394	+	Silent	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr15:48577394C>T	uc001zwn.3	+	21	2793	c.2577C>T	c.(2575-2577)GGC>GGT	p.G859G	SLC12A1_uc010uew.1_Silent_p.G665G|SLC12A1_uc001zwq.3_Silent_p.G630G|SLC12A1_uc001zwr.3_Silent_p.G586G	NM_000338	NP_000329	Q13621	S12A1_HUMAN	sodium potassium chloride cotransporter 2	859	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport	integral to membrane|membrane fraction	sodium:potassium:chloride symporter activity			ovary(1)|central_nervous_system(1)	2		all_lung(180;0.00219)		all cancers(107;1.76e-09)|GBM - Glioblastoma multiforme(94;1.48e-06)	Bumetanide(DB00887)|Chlormerodrin(DB00534)|Chlorthalidone(DB00310)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Metolazone(DB00524)|Potassium Chloride(DB00761)|Torasemide(DB00214)|Trichlormethiazide(DB01021)	GCATCCGAGGCTTGTTTAAAA	0.363		NA											66	131					0	0	0	0
FBN1	2200	broad.mit.edu	37	15	48730063	48730063	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr15:48730063G>A	uc001zwx.1	-	51	6543	c.6215C>T	c.(6214-6216)TCA>TTA	p.S2072L	FBN1_uc010beo.1_RNA	NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	2072	TB 8.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		GGATTTGGGTGATGAACACTT	0.502		NA											14	167					0	0	0	0
USP8	9101	broad.mit.edu	37	15	50773685	50773685	+	Missense_Mutation	SNP	G	G	T	rs114434131	by1000genomes	TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr15:50773685G>T	uc001zym.3	+	12	1726	c.1226G>T	c.(1225-1227)CGT>CTT	p.R409L	USP8_uc001zyk.1_Missense_Mutation_p.R110L|USP8_uc001zyl.3_Missense_Mutation_p.R409L|USP8_uc001zyn.3_Missense_Mutation_p.R409L|USP8_uc010ufh.1_Missense_Mutation_p.R332L|USP8_uc010bev.1_Missense_Mutation_p.R38L	NM_001128611	NP_001122083	P40818	UBP8_HUMAN	ubiquitin specific peptidase 8	409	SH3-binding (By similarity).				cell cycle|cell proliferation|endosome organization|protein K48-linked deubiquitination|protein K63-linked deubiquitination|ubiquitin-dependent protein catabolic process	cytosol|early endosome|extrinsic to plasma membrane|nucleus	cysteine-type endopeptidase activity|SH3 domain binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(1)|central_nervous_system(1)	2				all cancers(107;0.000225)|GBM - Glioblastoma multiforme(94;0.000771)		TAGATTGATCGTACTAAAAAA	0.358		NA											15	25					1.52e-12	2.26e-12	1	0
TRPM7	54822	broad.mit.edu	37	15	50902065	50902065	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr15:50902065G>A	uc001zyt.3	-	18	2638	c.2374C>T	c.(2374-2376)CAT>TAT	p.H792Y	TRPM7_uc010bew.1_Missense_Mutation_p.H792Y|TRPM7_uc001zyu.2_Missense_Mutation_p.H350Y	NM_017672	NP_060142	Q96QT4	TRPM7_HUMAN	transient receptor potential cation channel,	792	Extracellular (Potential).				cell death	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein serine/threonine kinase activity			ovary(4)|stomach(3)|breast(1)|central_nervous_system(1)|skin(1)	10				all cancers(107;0.000819)|GBM - Glioblastoma multiforme(94;0.0045)		GTCATCTGATGAGCATCTTGA	0.358		NA											35	88					0	0	0	0
PRTG	283659	broad.mit.edu	37	15	55929374	55929374	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr15:55929374G>T	uc002adg.2	-	15	2665	c.2617C>A	c.(2617-2619)CGT>AGT	p.R873S		NM_173814	NP_776175	Q2VWP7	PRTG_HUMAN	protogenin precursor	873	Fibronectin type-III 5.				multicellular organismal development	integral to membrane				large_intestine(1)|ovary(1)|skin(1)	3				all cancers(107;0.00891)|GBM - Glioblastoma multiforme(80;0.135)		TTACCTTCACGGTGTAAGACC	0.393		NA											53	109					5.14e-22	8.21e-22	1	0
FAM63B	54629	broad.mit.edu	37	15	59146757	59146757	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr15:59146757G>C	uc002afj.2	+	9	2016	c.1814G>C	c.(1813-1815)CGA>CCA	p.R605P	FAM63B_uc002afi.2_Missense_Mutation_p.R604P|FAM63B_uc002afk.2_RNA|FAM63B_uc002afl.2_RNA	NM_001040450	NP_001035540	Q8NBR6	FA63B_HUMAN	hypothetical protein LOC54629 isoform a	605										central_nervous_system(1)	1						AAGGAACCACGAGAAAAAGAT	0.383		NA											12	67					0	0	0	0
GTF2A2	2958	broad.mit.edu	37	15	59934436	59934436	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr15:59934436C>A	uc002agg.2	-	4	385	c.203G>T	c.(202-204)TGC>TTC	p.C68F		NM_004492	NP_004483	P52657	T2AG_HUMAN	general transcription factor IIA, 2, 12kDa	68					interspecies interaction between organisms|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	transcription factor TFIIA complex	protein heterodimerization activity|protein homodimerization activity|TBP-class protein binding|transcription coactivator activity			central_nervous_system(2)	2						CACATTATCGCAGAATCTGTA	0.343		NA											37	104					3.76e-14	5.66e-14	1	0
MAP2K1	5604	broad.mit.edu	37	15	66777514	66777514	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr15:66777514G>A	uc010bhq.2	+	7	1355	c.880G>A	c.(880-882)GGG>AGG	p.G294R	MAP2K1_uc010ujp.1_Missense_Mutation_p.G272R	NM_002755	NP_002746	Q02750	MP2K1_HUMAN	mitogen-activated protein kinase kinase 1	294	Protein kinase.|Pro-rich.				activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|plasma membrane	ATP binding|MAP kinase kinase activity|protein serine/threonine kinase activity|protein tyrosine kinase activity				0						AAGGACCCCCGGGAGGCCCCT	0.607		NA							Cardiofaciocutaneous_syndrome				21	79					0	0	0	0
RASGRF1	5923	broad.mit.edu	37	15	79292109	79292109	+	Silent	SNP	G	G	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr15:79292109G>T	uc002beq.2	-	18	3145	c.2770C>A	c.(2770-2772)CGG>AGG	p.R924R	RASGRF1_uc002bep.2_Silent_p.R908R|RASGRF1_uc010blm.1_Silent_p.R833R|RASGRF1_uc002ber.3_Silent_p.R908R|RASGRF1_uc010unh.1_Silent_p.R319R|RASGRF1_uc002beo.2_Silent_p.R140R	NM_002891	NP_002882	Q13972	RGRF1_HUMAN	Ras protein-specific guanine	926					activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			skin(4)|ovary(1)|central_nervous_system(1)	6						GACATCCTCCGGTACTTCTCC	0.607		NA											38	120					9.89e-21	1.56e-20	1	0
EFTUD1	79631	broad.mit.edu	37	15	82523196	82523196	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr15:82523196C>A	uc002bgt.1	-	8	1017	c.848G>T	c.(847-849)GGT>GTT	p.G283V	EFTUD1_uc002bgu.1_Missense_Mutation_p.G232V	NM_024580	NP_078856	Q7Z2Z2	ETUD1_HUMAN	elongation factor Tu GTP binding domain	283					mature ribosome assembly		GTP binding|GTPase activity|ribosome binding|translation elongation factor activity			ovary(1)	1						TACCTGATCACCCTTCATGAT	0.323		NA											8	135					0.00307968	0.00407266	1	0
MRPS11	64963	broad.mit.edu	37	15	89015921	89015921	+	Silent	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr15:89015921G>A	uc002bml.2	+	3	511	c.246G>A	c.(244-246)GAG>GAA	p.E82E	MRPS11_uc002bmm.2_Intron|MRPS11_uc002bmn.2_Silent_p.E81E|MRPS11_uc010bnj.2_RNA	NM_022839	NP_073750	P82912	RT11_HUMAN	mitochondrial ribosomal protein S11 isoform a	82					DNA damage response, detection of DNA damage|translation	mitochondrial small ribosomal subunit	structural constituent of ribosome				0	Lung NSC(78;0.203)		BRCA - Breast invasive adenocarcinoma(143;0.188)			AATTTGAGGAGATCCCAATTG	0.443		NA											4	56					0	0	0	0
MFGE8	4240	broad.mit.edu	37	15	89453073	89453073	+	Missense_Mutation	SNP	G	G	A	rs145851768		TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr15:89453073G>A	uc002bng.3	-	2	268	c.155C>T	c.(154-156)TCG>TTG	p.S52L	MFGE8_uc002bnf.3_5'UTR|MFGE8_uc002bnh.3_Missense_Mutation_p.S52L|MFGE8_uc010bnn.2_Missense_Mutation_p.S44L|MFGE8_uc010upq.1_Intron|MFGE8_uc010upr.1_Missense_Mutation_p.S52L|MFGE8_uc010bno.2_Intron	NM_005928	NP_005919	Q08431	MFGM_HUMAN	milk fat globule-EGF factor 8 protein isoform a	52	EGF-like.				angiogenesis|cell adhesion|interspecies interaction between organisms|single fertilization					ovary(1)	1	Lung NSC(78;0.0392)|all_lung(78;0.077)					GCAGGTGTACGAGGGGAAGAC	0.542		NA											38	225					0	0	0	0
FANCI	55215	broad.mit.edu	37	15	89837176	89837176	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr15:89837176G>A	uc010bnp.1	+	23	2494	c.2404G>A	c.(2404-2406)GAT>AAT	p.D802N	FANCI_uc002bnm.1_Missense_Mutation_p.D802N|FANCI_uc002bnn.1_RNA|FANCI_uc002bnp.1_Missense_Mutation_p.D623N|FANCI_uc002bnq.1_Missense_Mutation_p.D215N	NM_001113378	NP_001106849	Q9NVI1	FANCI_HUMAN	Fanconi anemia, complementation group I isoform	802					cell cycle|DNA repair	nucleoplasm	protein binding			ovary(2)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)					CAAGACAAGTGATAGTCTTTT	0.398		NA						Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				27	139					0	0	0	0
POLG	5428	broad.mit.edu	37	15	89862533	89862533	+	Silent	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr15:89862533G>A	uc002bns.3	-	19	3312	c.3030C>T	c.(3028-3030)CTC>CTT	p.L1010L	POLG_uc002bnr.3_Silent_p.L1010L	NM_002693	NP_002684	P54098	DPOG1_HUMAN	DNA-directed DNA polymerase gamma	1010					base-excision repair, gap-filling|cell death|DNA-dependent DNA replication	mitochondrial nucleoid	DNA binding|DNA-directed DNA polymerase activity|protease binding			ovary(1)|lung(1)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)		STAD - Stomach adenocarcinoma(125;0.165)			TGTCCACTGGGAGGTTCAACT	0.557		NA						DNA_polymerases_(catalytic_subunits)					4	73					0	0	0	0
FES	2242	broad.mit.edu	37	15	91436009	91436009	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr15:91436009G>C	uc002bpv.2	+	14	1876	c.1780G>C	c.(1780-1782)GAG>CAG	p.E594Q	FES_uc010uqj.1_Missense_Mutation_p.E466Q|FES_uc010uqk.1_Missense_Mutation_p.E576Q|FES_uc002bpw.2_RNA|FES_uc010bny.2_Missense_Mutation_p.E466Q|FES_uc002bpx.2_Missense_Mutation_p.E524Q|FES_uc002bpy.2_Missense_Mutation_p.E536Q	NM_002005	NP_001996	P07332	FES_HUMAN	feline sarcoma oncogene isoform 1	594	Protein kinase.				axon guidance|cell proliferation|peptidyl-tyrosine phosphorylation	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(2)	2	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			GTCTTGTCGAGAGACGCTCCC	0.572		NA											8	125					0	0	0	0
MCTP2	55784	broad.mit.edu	37	15	94928705	94928705	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr15:94928705G>T	uc002btj.2	+	13	1804	c.1739G>T	c.(1738-1740)GGA>GTA	p.G580V	MCTP2_uc002bti.2_Missense_Mutation_p.G580V|MCTP2_uc010boj.2_Missense_Mutation_p.G309V|MCTP2_uc010bok.2_Missense_Mutation_p.G580V|MCTP2_uc002btk.3_Missense_Mutation_p.G168V|MCTP2_uc002btl.2_Missense_Mutation_p.G168V	NM_018349	NP_060819	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2 isoform 1	580	C2 3.				calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(1)|pancreas(1)|skin(1)	3	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			GATGAAGATGGAGATAAACCC	0.338		NA											74	263					7.09e-46	1.2e-45	1	0
HBM	3042	broad.mit.edu	37	16	216015	216015	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr16:216015C>A	uc002cfu.1	+	1	43	c.19C>A	c.(19-21)CGC>AGC	p.R7S		NM_001003938	NP_001003938	Q6B0K9	HBM_HUMAN	hemoglobin mu chain	7						hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity				0		all_cancers(16;1.62e-06)|all_epithelial(16;4.01e-06)|Hepatocellular(16;0.000325)|Lung NSC(18;0.0104)|all_lung(18;0.0239)				CGCCCAGGAGCGCGCCCAAAT	0.721		NA											9	21					0.000442599	0.000594192	1	0
ACSM5	54988	broad.mit.edu	37	16	20439173	20439173	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr16:20439173C>T	uc002dhe.2	+	7	1132	c.985C>T	c.(985-987)CAG>TAG	p.Q329*		NM_017888	NP_060358	Q6NUN0	ACSM5_HUMAN	acyl-CoA synthetase medium-chain family member 5	329					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			ovary(2)	2						GCTGCTTGTGCAGGAGGATCT	0.463		NA											6	231					0	0	0	0
ACSM2A	123876	broad.mit.edu	37	16	20476886	20476886	+	Silent	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr16:20476886G>A	uc010bwe.2	+	4	464	c.225G>A	c.(223-225)AAG>AAA	p.K75K	ACSM2A_uc010bwd.1_RNA|ACSM2A_uc010vax.1_5'UTR|ACSM2A_uc002dhf.3_Silent_p.K75K|ACSM2A_uc002dhg.3_Silent_p.K75K|ACSM2A_uc010vay.1_5'UTR	NM_001010845	NP_001010845	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member	75					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			skin(2)|breast(1)	3						TGAATGGGAAGGGGAAGGAAT	0.572		NA											6	72					0	0	0	0
ACSM2B	348158	broad.mit.edu	37	16	20570722	20570722	+	Silent	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr16:20570722C>T	uc002dhj.3	-	4	435	c.225G>A	c.(223-225)AAG>AAA	p.K75K	ACSM2B_uc002dhk.3_Silent_p.K75K|ACSM2B_uc010bwf.1_Silent_p.K75K	NM_182617	NP_872423	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member	75					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5						ATTCCTTCCCCTTCCCATTCA	0.557		NA											18	31					0	0	0	0
ZP2	7783	broad.mit.edu	37	16	21215680	21215680	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr16:21215680T>C	uc002dii.2	-	8	739	c.739A>G	c.(739-741)ATA>GTA	p.I247V	ZP2_uc010bwn.1_Missense_Mutation_p.I286V|ZP2_uc010bwo.2_Missense_Mutation_p.I286V	NM_003460	NP_003451	Q05996	ZP2_HUMAN	zona pellucida glycoprotein 2 preproprotein	247	Extracellular (Potential).				binding of sperm to zona pellucida|intracellular protein transport	endoplasmic reticulum|Golgi apparatus|integral to membrane|multivesicular body|plasma membrane|proteinaceous extracellular matrix|stored secretory granule	acrosin binding|coreceptor activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(48;0.0573)		CCAGGAGATATAAATGTAAGC	0.428		NA											32	40					0	0	0	0
ARHGAP17	55114	broad.mit.edu	37	16	24958893	24958893	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr16:24958893T>C	uc002dnb.2	-	14	1244	c.1151A>G	c.(1150-1152)AAG>AGG	p.K384R	ARHGAP17_uc002dna.2_Missense_Mutation_p.K111R|ARHGAP17_uc002dnc.2_Missense_Mutation_p.K384R|ARHGAP17_uc010vcf.1_Missense_Mutation_p.K205R	NM_001006634	NP_001006635	Q68EM7	RHG17_HUMAN	nadrin isoform 1	384	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|tight junction	GTPase activator activity|SH3 domain binding				0				GBM - Glioblastoma multiforme(48;0.0407)		CTGAGCAAGCTTTGCAAGGAA	0.463		NA											3	71					0	0	0	0
SEPHS2	22928	broad.mit.edu	37	16	30456514	30456514	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr16:30456514C>A	uc010ves.1	-	2	711	c.535G>T	c.(535-537)GTC>TTC	p.V179F	SEPHS2_uc002dyh.1_Missense_Mutation_p.V122F|SEPHS2_uc010vet.1_Missense_Mutation_p.V61F	NM_012248	NP_036380	Q99611	SPS2_HUMAN	selenophosphate synthetase 2	179					selenocysteine biosynthetic process		ATP binding|selenide, water dikinase activity			breast(2)	2						CTCTGGCTGACGCTGAGTAAC	0.547		NA											62	75					2.73e-28	4.45e-28	1	0
ITGAL	3683	broad.mit.edu	37	16	30495265	30495265	+	Silent	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr16:30495265C>T	uc002dyi.3	+	8	1016	c.840C>T	c.(838-840)ATC>ATT	p.I280I	ITGAL_uc010veu.1_RNA|ITGAL_uc002dyj.3_Silent_p.I197I|ITGAL_uc010vev.1_Intron	NM_002209	NP_002200	P20701	ITAL_HUMAN	integrin alpha L isoform a precursor	280	VWFA.|Extracellular (Potential).				blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			ovary(3)|lung(3)|central_nervous_system(3)|breast(1)	10					Efalizumab(DB00095)	AAGACATCATCCGCTACATCA	0.582		NA											5	249					0	0	0	0
RNF40	9810	broad.mit.edu	37	16	30779633	30779633	+	Silent	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr16:30779633G>A	uc002dzq.2	+	13	1884	c.1761G>A	c.(1759-1761)GAG>GAA	p.E587E	RNF40_uc010caa.2_Silent_p.E587E|RNF40_uc010cab.2_Silent_p.E487E|RNF40_uc010vfa.1_5'UTR|RNF40_uc002dzr.2_Silent_p.E587E|RNF40_uc010vfb.1_Silent_p.E279E|RNF40_uc010vfc.1_5'UTR	NM_014771	NP_055586	O75150	BRE1B_HUMAN	ring finger protein 40	587					histone H2B ubiquitination|histone monoubiquitination|ubiquitin-dependent protein catabolic process	nucleus|synaptosome|ubiquitin ligase complex	protein homodimerization activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)	1			Colorectal(24;0.198)			CCTCTGAAGAGGACTTCCAGG	0.622		NA											15	28					0	0	0	0
C16orf57	79650	broad.mit.edu	37	16	58043902	58043902	+	Missense_Mutation	SNP	G	G	A	rs142683238	byFrequency	TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr16:58043902G>A	uc002emz.2	+	3	418	c.335G>A	c.(334-336)CGG>CAG	p.R112Q	C16orf57_uc010via.1_Missense_Mutation_p.R112Q|C16orf57_uc002emy.2_RNA|C16orf57_uc010vib.1_Missense_Mutation_p.R112Q|C16orf57_uc010vic.1_Missense_Mutation_p.R61Q	NM_024598	NP_078874	Q9BQ65	CP057_HUMAN	hypothetical protein LOC79650	112											0						TATGTCCCCCGGCTGGTAAGG	0.592		NA											9	260					0	0	0	0
CA7	766	broad.mit.edu	37	16	66881111	66881111	+	Silent	SNP	T	T	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr16:66881111T>C	uc002eqi.2	+	2	328	c.219T>C	c.(217-219)AAT>AAC	p.N73N	uc002eqh.2_Intron|CA7_uc002eqj.2_Silent_p.N17N	NM_005182	NP_005173	P43166	CAH7_HUMAN	carbonic anhydrase VII isoform 1	73					one-carbon metabolic process	cytoplasm	carbonate dehydratase activity|zinc ion binding				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.088)|Epithelial(162;0.204)		TAGACTTCAATGACAGCGATG	0.582		NA											23	46					0	0	0	0
PARD6A	50855	broad.mit.edu	37	16	67694944	67694944	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr16:67694944G>C	uc002ett.2	+	1	94	c.3G>C	c.(1-3)ATG>ATC	p.M1I	ACD_uc002etp.3_5'Flank|ACD_uc002etq.3_5'Flank|ACD_uc002etr.3_5'Flank|ACD_uc010vjt.1_5'Flank|PARD6A_uc002ets.2_Missense_Mutation_p.M1I|PARD6A_uc002etu.2_5'Flank	NM_016948	NP_058644	Q9NPB6	PAR6A_HUMAN	par-6 partitioning defective 6 homolog alpha	1	Interaction with PRKCI and PRKCZ.				cell cycle|cell division|cell-cell junction maintenance|tight junction assembly|viral reproduction	cytosol|nucleus|ruffle|tight junction	GTP-dependent protein binding|Rho GTPase binding|transcription factor binding			ovary(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.047)|all cancers(182;0.228)		gccccgccATGGCCCGGCCGC	0.363		NA											23	47					0	0	0	0
EDC4	23644	broad.mit.edu	37	16	67913615	67913615	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr16:67913615G>T	uc002eur.2	+	15	1925	c.1759G>T	c.(1759-1761)GAG>TAG	p.E587*	EDC4_uc010cer.2_Nonsense_Mutation_p.E206*|EDC4_uc010vkg.1_Nonsense_Mutation_p.E519*|EDC4_uc010ces.1_Nonsense_Mutation_p.E375*|EDC4_uc002eus.2_Nonsense_Mutation_p.E317*|EDC4_uc002eut.1_5'Flank	NM_014329	NP_055144	Q6P2E9	EDC4_HUMAN	autoantigen RCD8	587					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			ovary(2)|central_nervous_system(2)	4		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)		TCTGAGCAGTGAGACCAAGCC	0.632		NA											7	231					0.000274275	0.000368916	1	0
SLC7A6OS	84138	broad.mit.edu	37	16	68337973	68337973	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr16:68337973C>G	uc002evw.1	-	3	653	c.634G>C	c.(634-636)GAG>CAG	p.E212Q		NM_032178	NP_115554	Q96CW6	S7A6O_HUMAN	solute carrier family 7, member 6 opposite	212					protein transport	cytoplasm|nucleus				ovary(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.034)|Epithelial(162;0.106)		AGGATGTTCTCAATCCAGCCT	0.527		NA											10	145					0	0	0	0
CDH3	1001	broad.mit.edu	37	16	68729192	68729192	+	Silent	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr16:68729192G>A	uc002ewf.2	+	14	3169	c.2037G>A	c.(2035-2037)AAG>AAA	p.K679K	CDH3_uc010vli.1_Silent_p.K624K	NM_001793	NP_001784	P22223	CADH3_HUMAN	cadherin 3, type 1 preproprotein	679	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|response to stimulus|visual perception	integral to membrane	calcium ion binding	p.?(1)		ovary(3)|breast(1)|skin(1)	5		Ovarian(137;0.0564)		OV - Ovarian serous cystadenocarcinoma(108;0.000782)|Epithelial(162;0.0054)|all cancers(182;0.0384)		TGGTGAGAAAGAAGCGGAAGA	0.587		NA											11	73					0	0	0	0
CHST4	10164	broad.mit.edu	37	16	71570718	71570718	+	Silent	SNP	G	G	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr16:71570718G>T	uc002fan.2	+	2	319	c.138G>T	c.(136-138)CTG>CTT	p.L46L	CHST4_uc002fao.2_Silent_p.L46L	NM_005769	NP_005760	Q8NCG5	CHST4_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	46	Lumenal (Potential).				cell-cell signaling|immune response|inflammatory response|N-acetylglucosamine metabolic process|protein sulfation	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity				0						TGCACGTGCTGGTTCTGTCTT	0.557		NA											5	189					0.000602214	0.000802385	1	0
ATP2C2	9914	broad.mit.edu	37	16	84485542	84485542	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr16:84485542C>G	uc002fhx.2	+	18	1765	c.1676C>G	c.(1675-1677)TCT>TGT	p.S559C	ATP2C2_uc010chj.2_Missense_Mutation_p.S559C|ATP2C2_uc002fhy.2_Missense_Mutation_p.S576C|ATP2C2_uc002fhz.2_Missense_Mutation_p.S408C	NM_014861	NP_055676	O75185	AT2C2_HUMAN	ATPase, Ca++ transporting, type 2C, member 2	559	Extracellular (Potential).				ATP biosynthetic process	Golgi membrane|integral to membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)	2						GCCCTGGCTTCTGGGCCCGAG	0.542		NA											25	308					0	0	0	0
ANKRD11	29123	broad.mit.edu	37	16	89371734	89371734	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr16:89371734G>C	uc002fmx.1	-	4	567	c.106C>G	c.(106-108)CTA>GTA	p.L36V	ANKRD11_uc002fmy.1_Missense_Mutation_p.L36V|ANKRD11_uc002fnc.1_Missense_Mutation_p.L36V|ANKRD11_uc002fnd.2_5'UTR|ANKRD11_uc002fne.2_5'UTR|ANKRD11_uc002fng.1_Missense_Mutation_p.L36V|ANKRD11_uc002fnf.1_Missense_Mutation_p.L36V	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	36						nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		GTCTTGGTTAGAGAAACTTTA	0.507		NA											7	115					0	0	0	0
SMYD4	114826	broad.mit.edu	37	17	1703541	1703541	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr17:1703541C>T	uc002ftm.3	-	5	1315	c.1147G>A	c.(1147-1149)GAA>AAA	p.E383K	SMYD4_uc002ftn.1_Missense_Mutation_p.E238K	NM_052928	NP_443160	Q8IYR2	SMYD4_HUMAN	SET and MYND domain containing 4	383							zinc ion binding			skin(3)|kidney(2)	5						TTGTTGCTTTCAGGTAAACAG	0.418		NA											17	196					0	0	0	0
RPA1	6117	broad.mit.edu	37	17	1747221	1747221	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr17:1747221G>A	uc002fto.2	+	3	207	c.92G>A	c.(91-93)CGT>CAT	p.R31H		NM_002945	NP_002936	P27694	RFA1_HUMAN	replication protein A1	31					cell cycle checkpoint|DNA recombinase assembly|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	actin cytoskeleton|cytoplasm|DNA replication factor A complex|PML body	metal ion binding|protein binding|single-stranded DNA binding				0						TAGAACATCCGTCCCATTACT	0.488		NA						NER					69	36					0	0	0	0
METT10D	79066	broad.mit.edu	37	17	2323539	2323539	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr17:2323539C>A	uc002fut.2	-	10	1562	c.1414G>T	c.(1414-1416)GGA>TGA	p.G472*	METT10D_uc002fuu.3_RNA|METT10D_uc010cka.2_RNA|METT10D_uc002fuv.2_Intron|METT10D_uc010vqx.1_RNA|METT10D_uc010vqy.1_Nonsense_Mutation_p.G254*	NM_024086	NP_076991	Q86W50	MET16_HUMAN	methyltransferase 10 domain containing	472							methyltransferase activity				0						TCCACCCCTCCCTTTTCCTCA	0.617		NA											95	281					6.45e-38	1.08e-37	1	0
CAMTA2	23125	broad.mit.edu	37	17	4883457	4883457	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr17:4883457C>A	uc002gah.1	-	9	1268	c.1160G>T	c.(1159-1161)GGC>GTC	p.G387V	CAMTA2_uc010cku.1_Missense_Mutation_p.G410V|CAMTA2_uc002gag.1_Missense_Mutation_p.G386V|CAMTA2_uc002gai.1_Missense_Mutation_p.G389V|CAMTA2_uc010ckv.1_Missense_Mutation_p.G34V|CAMTA2_uc010vsu.1_Missense_Mutation_p.G200V	NM_015099	NP_055914	O94983	CMTA2_HUMAN	calmodulin binding transcription activator 2	387					cardiac muscle hypertrophy in response to stress|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	calmodulin binding|chromatin binding|histone deacetylase binding|transcription factor binding			ovary(1)	1						ATATGTCTGGCCCCTCTGGGG	0.617		NA											28	79					4.78e-09	6.88e-09	1	0
MYH4	4622	broad.mit.edu	37	17	10353772	10353772	+	Silent	SNP	G	G	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr17:10353772G>T	uc002gmn.2	-	30	4290	c.4179C>A	c.(4177-4179)GCC>GCA	p.A1393A	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	1393	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						GCACATACTTGGCCTCCTCCA	0.517		NA											83	171					2.93e-43	4.95e-43	1	0
MYO15A	51168	broad.mit.edu	37	17	18070960	18070960	+	Silent	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr17:18070960C>T	uc010vxh.1	+	61	10343	c.10005C>T	c.(10003-10005)AGC>AGT	p.S3335S	MYO15A_uc010vxi.1_Silent_p.S599S|MYO15A_uc010vxk.1_Silent_p.S28S|MYO15A_uc010vxl.1_Silent_p.S324S|MYO15A_uc002gsl.2_Silent_p.S342S|MYO15A_uc010vxm.1_Intron|MYO15A_uc010cpv.2_RNA	NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	3335	Tail.|FERM.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					GCCGGCCCAGCGAGCAGCTGC	0.662		NA											23	45					0	0	0	0
NF1	4763	broad.mit.edu	37	17	29490331	29490331	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr17:29490331C>G	uc002hgg.2	+	4	749	c.416C>G	c.(415-417)TCT>TGT	p.S139C	NF1_uc002hge.1_Missense_Mutation_p.S139C|NF1_uc002hgf.1_Missense_Mutation_p.S139C|NF1_uc002hgh.2_Missense_Mutation_p.S139C|NF1_uc010csn.1_Missense_Mutation_p.L35V	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	139					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(5)|p.?(4)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		AATTCTGCCTCTGGGGTTTTA	0.443		NA	D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			3	96					0	0	0	0
NF1	4763	broad.mit.edu	37	17	29528502	29528502	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr17:29528502A>T	uc002hgg.2	+	11	1592	c.1259A>T	c.(1258-1260)AAT>ATT	p.N420I	NF1_uc002hge.1_Missense_Mutation_p.N420I|NF1_uc002hgf.1_Missense_Mutation_p.N420I|NF1_uc002hgh.2_Missense_Mutation_p.N420I|NF1_uc010csn.1_Missense_Mutation_p.N280I	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	420					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(2)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		ATCATCACCAATGTAAGTCCA	0.313		NA	D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			148	90					0	0	0	0
EVI2B	2124	broad.mit.edu	37	17	29631403	29631403	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr17:29631403C>T	uc002hgk.2	-	2	1380	c.1225G>A	c.(1225-1227)GAT>AAT	p.D409N	NF1_uc002hgg.2_Intron|NF1_uc002hgh.2_Intron|NF1_uc002hgi.1_Intron|NF1_uc010cso.2_Intron|EVI2B_uc010csq.2_Missense_Mutation_p.D424N	NM_006495	NP_006486	P34910	EVI2B_HUMAN	ecotropic viral integration site 2B precursor	409	Cytoplasmic (Potential).					cytoplasm|integral to plasma membrane				ovary(2)	2		all_cancers(10;6.97e-11)|all_epithelial(10;0.0051)|all_hematologic(16;0.0149)|Breast(31;0.0155)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0257)|all_lung(9;0.0468)|Lung NSC(157;0.094)		UCEC - Uterine corpus endometrioid carcinoma (4;6.64e-05)|all cancers(4;6.88e-13)|Epithelial(4;8.95e-12)|OV - Ovarian serous cystadenocarcinoma(4;1.01e-11)|GBM - Glioblastoma multiforme(4;0.184)		TTCATAAAATCTACTGGTGGC	0.423		NA											40	91					0	0	0	0
MYO19	80179	broad.mit.edu	37	17	34863652	34863652	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr17:34863652C>G	uc010wcy.1	-	16	2335	c.1343G>C	c.(1342-1344)AGG>ACG	p.R448T	MYO19_uc002hmw.2_Intron|MYO19_uc010cuu.2_RNA|MYO19_uc010wcz.1_RNA	NM_001163735	NP_001157207	Q96H55	MYO19_HUMAN	myosin XIX isoform 2	448	Myosin head-like.					mitochondrial outer membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)	1		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		CTGCTGGGCCCTTAGGTAGTG	0.512		NA											14	29					0	0	0	0
KRT24	192666	broad.mit.edu	37	17	38858167	38858167	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr17:38858167C>G	uc002hvd.2	-	2	691	c.634G>C	c.(634-636)GAA>CAA	p.E212Q		NM_019016	NP_061889	Q2M2I5	K1C24_HUMAN	keratin 24	212	Rod.|Coil 1B.					cytoplasm|intermediate filament	structural molecule activity				0		Breast(137;0.00526)				CCAGCATTTTCAACAGTGGCA	0.393		NA											3	48					0	0	0	0
KRT24	192666	broad.mit.edu	37	17	38859533	38859533	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr17:38859533C>G	uc002hvd.2	-	1	470	c.413G>C	c.(412-414)GGA>GCA	p.G138A		NM_019016	NP_061889	Q2M2I5	K1C24_HUMAN	keratin 24	138	Head.|Gly-rich.					cytoplasm|intermediate filament	structural molecule activity				0		Breast(137;0.00526)				CTTTTCCCCTCCAGAGAAAAG	0.522		NA											30	371					0	0	0	0
KRT25	147183	broad.mit.edu	37	17	38906696	38906696	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr17:38906696C>G	uc002hve.2	-	6	1172	c.1111G>C	c.(1111-1113)GAC>CAC	p.D371H		NM_181534	NP_853512	Q7Z3Z0	K1C25_HUMAN	keratin 25	371	Rod.|Coil 2.					cytoplasm|intermediate filament	structural molecule activity	p.D371N(1)		ovary(2)	2		Breast(137;0.00526)				AGCTTGATGTCCAGGAGCTGC	0.527		NA											91	337					0	0	0	0
KRT25	147183	broad.mit.edu	37	17	38906822	38906822	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr17:38906822C>A	uc002hve.2	-	6	1046	c.985G>T	c.(985-987)GAG>TAG	p.E329*		NM_181534	NP_853512	Q7Z3Z0	K1C25_HUMAN	keratin 25	329	Rod.|Coil 2.					cytoplasm|intermediate filament	structural molecule activity			ovary(2)	2		Breast(137;0.00526)				CTCTCGGTCTCTGTCAAGGAG	0.527		NA											64	311					7.76e-34	1.29e-33	1	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274087	39274087	+	Missense_Mutation	SNP	G	G	C	rs141357429	by1000genomes	TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr17:39274087G>C	uc002hvz.2	-	1	520	c.481C>G	c.(481-483)CTG>GTG	p.L161V		NM_033059	NP_149048	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	161	27.|27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].					keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			ACTGGACGCAGGcagcagcag	0.323		NA											3	30					0	0	0	0
ABCA10	10349	broad.mit.edu	37	17	67197788	67197788	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr17:67197788G>A	uc010dfa.1	-	11	1907	c.1028C>T	c.(1027-1029)TCT>TTT	p.S343F	ABCA10_uc010wqt.1_RNA|ABCA10_uc010dfb.1_5'UTR|ABCA10_uc010dfc.1_Intron	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	343					transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					AAATAATGGAGAATCCCCATG	0.318		NA											13	56					0	0	0	0
C17orf95	124512	broad.mit.edu	37	17	74729274	74729274	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr17:74729274C>G	uc002jsr.2	+	3	631	c.299C>G	c.(298-300)TCT>TGT	p.S100C	C17orf95_uc002jsp.2_Missense_Mutation_p.S100C|C17orf95_uc002jsq.2_RNA|C17orf95_uc002jss.2_Missense_Mutation_p.S100C|C17orf95_uc002jst.2_Missense_Mutation_p.S33C|C17orf95_uc002jsu.2_Intron|MFSD11_uc002jsz.1_5'Flank|MFSD11_uc002jta.2_5'Flank	NM_001080510	NP_001073979	Q86XA0	MET23_HUMAN	hypothetical protein LOC124512	100						integral to membrane	methyltransferase activity				0						ATCCTTGCATCTGATGTGTTC	0.403		NA											4	60					0	0	0	0
RNF213	57674	broad.mit.edu	37	17	78327389	78327389	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr17:78327389G>C	uc002jyh.1	+	9	4943	c.4720G>C	c.(4720-4722)GAG>CAG	p.E1574Q	uc002jyi.1_RNA|RNF213_uc010dhw.1_5'Flank	NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			GGAGGTGGCAGAGGTGGCAGA	0.567		NA											5	78					0	0	0	0
KIAA0802	23255	broad.mit.edu	37	18	8783661	8783661	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr18:8783661A>C	uc002knr.2	+	6	693	c.551A>C	c.(550-552)TAT>TCT	p.Y184S	KIAA0802_uc002knq.2_Missense_Mutation_p.Y184S|KIAA0802_uc010dkw.1_Missense_Mutation_p.Y22S	NM_015210	NP_056025	Q9Y4B5	CC165_HUMAN	hypothetical protein LOC23255	535	Potential.										0						AAGTCCCTCTATGGGGATGTG	0.612		NA											3	44					0	0	0	0
POTEC	388468	broad.mit.edu	37	18	14542977	14542977	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr18:14542977G>A	uc010dln.2	-	1	623	c.169C>T	c.(169-171)CTC>TTC	p.L57F	POTEC_uc010xaj.1_RNA	NM_001137671	NP_001131143	B2RU33	POTEC_HUMAN	ANKRD26-like family B, member 2	57										skin(3)	3						TTGCTCCTGAGCATCTTCATA	0.587		NA											108	687					0	0	0	0
DSG3	1830	broad.mit.edu	37	18	29052738	29052738	+	Silent	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr18:29052738C>T	uc002kws.2	+	14	2197	c.2088C>T	c.(2086-2088)TTC>TTT	p.F696F	DSG3_uc002kwt.2_5'Flank	NM_001944	NP_001935	P32926	DSG3_HUMAN	desmoglein 3 preproprotein	696	Cytoplasmic (Potential).				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			skin(4)|ovary(3)|lung(1)|central_nervous_system(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			GAGCCGATTTCATGGAAAGTT	0.323		NA											4	53					0	0	0	0
ASXL3	80816	broad.mit.edu	37	18	31325388	31325388	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr18:31325388G>T	uc010dmg.1	+	12	5631	c.5576G>T	c.(5575-5577)TGT>TTT	p.C1859F	ASXL3_uc002kxq.2_Missense_Mutation_p.C1566F	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	1859					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						GGGGTGCCTTGTGTCATCAGT	0.468		NA											18	548					1.34e-09	1.94e-09	1	0
ELP2	55250	broad.mit.edu	37	18	33750144	33750144	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr18:33750144T>G	uc002kzk.1	+	20	2205	c.2195T>G	c.(2194-2196)CTC>CGC	p.L732R	ELP2_uc010xcg.1_Missense_Mutation_p.L797R|ELP2_uc002kzl.1_RNA|ELP2_uc002kzm.1_Missense_Mutation_p.L706R|ELP2_uc010xch.1_Missense_Mutation_p.L727R|ELP2_uc002kzn.1_Missense_Mutation_p.L662R|ELP2_uc002kzo.1_Missense_Mutation_p.L662R	NM_018255	NP_060725	Q6IA86	ELP2_HUMAN	elongator protein 2	732	WD 13.				regulation of transcription from RNA polymerase II promoter	Golgi apparatus|transcription elongation factor complex				breast(2)|ovary(1)|skin(1)	4						TGCCCAGTGCTCCACCCTTCT	0.512		NA											54	98					0	0	0	0
RIT2	6014	broad.mit.edu	37	18	40613778	40613778	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr18:40613778A>G	uc002lav.2	-	2	331	c.158T>C	c.(157-159)ATA>ACA	p.I53T	RIT2_uc010dnf.2_Missense_Mutation_p.I53T	NM_002930	NP_002921	Q99578	RIT2_HUMAN	Ras-like without CAAX 2	53					nerve growth factor receptor signaling pathway|small GTPase mediated signal transduction|synaptic transmission	intracellular|plasma membrane	calmodulin binding|GTP binding|GTPase activity			ovary(1)	1						CCACTTACCTATAGTAGGGTC	0.308		NA											21	17					0	0	0	0
SLC14A1	6563	broad.mit.edu	37	18	43310367	43310367	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr18:43310367A>G	uc010xcn.1	+	4	401	c.82A>G	c.(82-84)AGA>GGA	p.R28G	SLC14A1_uc010dnk.2_Missense_Mutation_p.R84G|SLC14A1_uc002lbf.3_Missense_Mutation_p.R28G|SLC14A1_uc002lbg.3_RNA|SLC14A1_uc010xco.1_Intron|SLC14A1_uc002lbh.3_Intron|SLC14A1_uc002lbi.3_Intron|SLC14A1_uc002lbj.3_Missense_Mutation_p.R84G|SLC14A1_uc002lbk.3_Missense_Mutation_p.R28G	NM_001146036	NP_001139508	Q13336	UT1_HUMAN	solute carrier family 14 (urea transporter),	28						integral to plasma membrane	urea transmembrane transporter activity			central_nervous_system(1)|pancreas(1)	2						ATGTCAAGGGAGAAGGTGCTT	0.498		NA											6	121					0	0	0	0
AP3D1	8943	broad.mit.edu	37	19	2109958	2109958	+	Splice_Site	SNP	C	C	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr19:2109958C>G	uc002luz.2	-	27	3302	c.3079_splice	c.e27-1	p.N1027_splice	AP3D1_uc010dsv.2_Splice_Site_p.N117_splice|AP3D1_uc002luy.2_Splice_Site_p.N986_splice|AP3D1_uc002lva.2_Splice_Site_p.N1089_splice	NM_003938	NP_003929	O14617	AP3D1_HUMAN	adaptor-related protein complex 3, delta 1						eye pigment biosynthetic process|intracellular protein transport|regulation of sequestering of zinc ion|vesicle-mediated transport	endosome membrane|Golgi membrane|membrane coat	binding|protein transporter activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTCGTCATTCTGCGGTGGAG	0.642		NA											19	56					0	0	0	0
EMR1	2015	broad.mit.edu	37	19	6924814	6924814	+	Silent	SNP	G	G	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr19:6924814G>T	uc002mfw.2	+	15	1955	c.1917G>T	c.(1915-1917)CTG>CTT	p.L639L	EMR1_uc010dvc.2_Intron|EMR1_uc010dvb.2_Silent_p.L587L|EMR1_uc010xji.1_Silent_p.L498L|EMR1_uc010xjj.1_Silent_p.L462L	NM_001974	NP_001965	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone	639	Helical; Name=2; (Potential).				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	all_hematologic(4;0.166)					ACCTCCACCTGCACCTCTGCG	0.552		NA											35	111					5.44e-19	8.45e-19	1	0
PCP2	126006	broad.mit.edu	37	19	7697683	7697683	+	Silent	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr19:7697683G>A	uc002mgz.2	-	2	312	c.85C>T	c.(85-87)CTG>TTG	p.L29L		NM_174895	NP_777555	Q8IVA1	PCP2_HUMAN	Purkinje cell protein 2	29	GoLoco 1.				signal transduction		GTPase activator activity				0						TGGCTCAGCAGATTGAAGAAG	0.672		NA											5	4					0	0	0	0
LRRC8E	80131	broad.mit.edu	37	19	7965435	7965435	+	Silent	SNP	A	A	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr19:7965435A>T	uc002mir.2	+	3	2129	c.2028A>T	c.(2026-2028)TCA>TCT	p.S676S		NM_025061	NP_079337	Q6NSJ5	LRC8E_HUMAN	leucine rich repeat containing 8 family, member	676						integral to membrane				lung(1)|pancreas(1)	2						GCCTGTGCTCAGGCCTCCGTC	0.632		NA											36	63					0	0	0	0
MUC16	94025	broad.mit.edu	37	19	9003657	9003657	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr19:9003657T>G	uc002mkp.2	-	49	40187	c.39983A>C	c.(39982-39984)AAT>ACT	p.N13328T	MUC16_uc010dwi.2_RNA|MUC16_uc010dwj.2_Missense_Mutation_p.N145T|MUC16_uc010xki.1_Intron	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	13330	Extracellular (Potential).|SEA 9.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GATGGTAAAATTGAGGGTGAA	0.483		NA											33	379					0	0	0	0
MUC16	94025	broad.mit.edu	37	19	9069584	9069584	+	Silent	SNP	A	A	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr19:9069584A>T	uc002mkp.2	-	3	18066	c.17862T>A	c.(17860-17862)GCT>GCA	p.A5954A		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	5956	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TCACAGGGAGAGCAGAAGTGG	0.488		NA											54	107					0	0	0	0
GADD45GIP1	90480	broad.mit.edu	37	19	13067806	13067806	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr19:13067806G>A	uc002mwb.2	-	1	245	c.221C>T	c.(220-222)TCG>TTG	p.S74L		NM_052850	NP_443082	Q8TAE8	G45IP_HUMAN	growth arrest and DNA-damage-inducible, gamma	74					cell cycle|interspecies interaction between organisms	nucleus	protein binding			ovary(1)|skin(1)	2						CGGCCATAACGAACCGGGGAC	0.706		NA											17	26					0	0	0	0
RFX1	5989	broad.mit.edu	37	19	14090331	14090331	+	Silent	SNP	T	T	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr19:14090331T>A	uc002mxv.2	-	7	1034	c.762A>T	c.(760-762)CCA>CCT	p.P254P	RFX1_uc010dzi.2_Silent_p.P254P	NM_002918	NP_002909	P22670	RFX1_HUMAN	regulatory factor X1	254					immune response	nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			lung(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(19;6.67e-23)			TGGGCGCTTGTGGAGTGGCCT	0.642		NA											38	120					0	0	0	0
ZNF14	7561	broad.mit.edu	37	19	19822966	19822966	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr19:19822966G>A	uc002nnk.1	-	4	1278	c.1124C>T	c.(1123-1125)TCC>TTC	p.S375F		NM_021030	NP_066358	P17017	ZNF14_HUMAN	zinc finger protein 14	375	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Renal(1328;0.0474)				AAGAGAAATGGACCAACTGAA	0.373		NA											17	116					0	0	0	0
MAG	4099	broad.mit.edu	37	19	35800952	35800952	+	Silent	SNP	G	G	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr19:35800952G>T	uc002nyy.1	+	8	1556	c.1407G>T	c.(1405-1407)GTG>GTT	p.V469V	MAG_uc002nyx.1_Silent_p.V469V|MAG_uc010eds.1_Silent_p.V444V|MAG_uc002nyz.1_Silent_p.V469V	NM_002361	NP_002352	P20916	MAG_HUMAN	myelin associated glycoprotein isoform a	469	Ig-like C2-type 4.|Extracellular (Potential).				blood coagulation|cell adhesion|leukocyte migration|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane	sugar binding			breast(3)|lung(2)|central_nervous_system(1)|skin(1)	7	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)	Renal(1328;0.242)	Epithelial(14;3.14e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.5e-18)|all cancers(14;1.5e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)			GCGGCCTCGTGCTCACCAGCA	0.687		NA											44	46					6.69e-21	1.06e-20	1	0
APLP1	333	broad.mit.edu	37	19	36362534	36362534	+	Silent	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr19:36362534C>T	uc002oce.2	+	5	696	c.558C>T	c.(556-558)CTC>CTT	p.L186L	APLP1_uc010xsz.1_Silent_p.L147L|APLP1_uc002ocf.2_Silent_p.L186L|APLP1_uc002ocg.2_Silent_p.L89L|APLP1_uc010xta.1_Silent_p.L180L	NM_005166	NP_005157	P51693	APLP1_HUMAN	amyloid precursor-like protein 1 isoform 2	186	Extracellular (Potential).				apoptosis|cell adhesion|cellular response to norepinephrine stimulus|endocytosis|negative regulation of cAMP biosynthetic process|nervous system development|organ morphogenesis	basement membrane|integral to membrane|perinuclear region of cytoplasm|plasma membrane	alpha-2A adrenergic receptor binding|alpha-2B adrenergic receptor binding|alpha-2C adrenergic receptor binding|heparin binding|identical protein binding|metal ion binding			ovary(2)	2	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CCCAGGGCCTCATCCTGCACG	0.652		NA											24	92					0	0	0	0
POU2F2	5452	broad.mit.edu	37	19	42597981	42597981	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr19:42597981C>G	uc002osp.2	-	12	1265	c.1198G>C	c.(1198-1200)GTT>CTT	p.V400L	POU2F2_uc002osn.2_Missense_Mutation_p.V384L|POU2F2_uc002oso.2_Missense_Mutation_p.V173L|POU2F2_uc002osq.2_Missense_Mutation_p.A384P|POU2F2_uc002osr.1_Missense_Mutation_p.V400L	NM_002698	NP_002689	P09086	PO2F2_HUMAN	POU domain, class 2, transcription factor 2	400	Leucine-zipper.				humoral immune response|transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2		Prostate(69;0.059)				CCTCCCTGACCTGTTGTGCTC	0.607		NA											15	250					0	0	0	0
CIC	23152	broad.mit.edu	37	19	42795409	42795409	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr19:42795409C>A	uc002otf.1	+	10	2529	c.2489C>A	c.(2488-2490)CCC>CAC	p.P830H		NM_015125	NP_055940	Q96RK0	CIC_HUMAN	capicua homolog	830	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(4)|breast(4)|lung(1)|central_nervous_system(1)|skin(1)	11		Prostate(69;0.00682)				TACATCCTGCCCACGCTGCCC	0.687		NA	T	DUX4	soft tissue sarcoma								14	18					0.00244969	0.00324258	1	0
TMEM145	284339	broad.mit.edu	37	19	42827922	42827922	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr19:42827922T>C	uc002otk.1	+	14	1434	c.1382T>C	c.(1381-1383)ATC>ACC	p.I461T	MEGF8_uc002otl.3_5'Flank	NM_173633	NP_775904	Q8NBT3	TM145_HUMAN	transmembrane protein 145	461						integral to membrane					0		Prostate(69;0.00682)				CTCTTCTCCATCCCCCCGCCC	0.582		NA											4	104					0	0	0	0
ZNF404	342908	broad.mit.edu	37	19	44376785	44376785	+	Silent	SNP	T	T	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr19:44376785T>C	uc002oxs.3	-	2	1581	c.1572A>G	c.(1570-1572)GAA>GAG	p.E524E		NM_001033719	NP_001028891	Q494X3	ZN404_HUMAN	zinc finger protein 404	527	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)				CCTTACCACATTCTTTGCATT	0.388		NA											19	15					0	0	0	0
KLK13	26085	broad.mit.edu	37	19	51563831	51563831	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr19:51563831C>A	uc002pvn.2	-	2	141	c.98G>T	c.(97-99)AGT>ATT	p.S33I	KLK13_uc002pvl.2_RNA|KLK13_uc002pvm.2_RNA|KLK13_uc002pvo.2_RNA|KLK13_uc002pvp.2_RNA|KLK13_uc010eon.2_Missense_Mutation_p.S33I|KLK13_uc002pvq.2_RNA|KLK13_uc010eoo.2_Intron|KLK13_uc002pvr.2_Missense_Mutation_p.S33I	NM_015596	NP_056411	Q9UKR3	KLK13_HUMAN	kallikrein 13 precursor	33					proteolysis		protein binding|serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00224)|GBM - Glioblastoma multiforme(134;0.00432)		GAGAAACCCACTGGTCCCATT	0.582		NA											69	85					1.34e-20	2.11e-20	1	0
ZNF615	284370	broad.mit.edu	37	19	52497539	52497539	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr19:52497539C>T	uc002pye.1	-	6	1082	c.790G>A	c.(790-792)GAA>AAA	p.E264K	ZNF615_uc002pyf.1_Missense_Mutation_p.E275K|ZNF615_uc002pyg.1_Missense_Mutation_p.E156K|ZNF615_uc002pyh.1_Missense_Mutation_p.E275K|ZNF615_uc010epi.1_Missense_Mutation_p.E271K|ZNF615_uc010ydg.1_Missense_Mutation_p.E269K	NM_198480	NP_940882	Q8N8J6	ZN615_HUMAN	zinc finger protein 615	264	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00142)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		TTGTCACATTCAGTGCATTCA	0.403		NA											16	154					0	0	0	0
ZNF836	162962	broad.mit.edu	37	19	52659425	52659426	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr19:52659425_52659426CC>AA	uc010ydi.1	-	5	1884_1885	c.1510_1511GG>TT	c.(1510-1512)GGT>TTT	p.G504F	ZNF836_uc010ydj.1_Missense_Mutation_p.G504F	NM_001102657	NP_001096127	Q6ZNA1	ZN836_HUMAN	zinc finger protein 836	504	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AAAGGCTTTACCACATTTATCA	0.406		NA											67	64					0	0	0	0
NLRP12	91662	broad.mit.edu	37	19	54318203	54318203	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr19:54318203G>C	uc002qch.3	-	2	549	c.329C>G	c.(328-330)TCA>TGA	p.S110*	NLRP12_uc002qci.3_Nonsense_Mutation_p.S110*|NLRP12_uc002qcj.3_Nonsense_Mutation_p.S110*|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_Nonsense_Mutation_p.S110*	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	110					negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		AAGGCATGTTGACTGGTTCCC	0.517		NA											15	127					0	0	0	0
LILRA1	11024	broad.mit.edu	37	19	55106848	55106848	+	Silent	SNP	C	C	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr19:55106848C>A	uc002qgh.1	+	5	824	c.642C>A	c.(640-642)CTC>CTA	p.L214L	LILRA2_uc010yfg.1_Intron|LILRA1_uc010yfh.1_Silent_p.L214L	NM_006863	NP_006854	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor,	214	Ig-like C2-type 2.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(193;0.0348)		CCAGTGATCTCCTGGAGCTCC	0.587		NA											13	205					6.32e-08	8.97e-08	1	0
NTSR2	23620	broad.mit.edu	37	2	11809734	11809734	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:11809734C>A	uc002rbq.3	-	1	596	c.522G>T	c.(520-522)ATG>ATT	p.M174I		NM_012344	NP_036476	O95665	NTR2_HUMAN	neurotensin receptor 2	174	Helical; Name=4; (Potential).				sensory perception	integral to plasma membrane					0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.129)|OV - Ovarian serous cystadenocarcinoma(76;0.24)	Levocabastine(DB01106)	GCTTCTGCCCCATGATGACGG	0.721		NA											19	14					2.94e-08	4.2e-08	1	0
ITSN2	50618	broad.mit.edu	37	2	24507701	24507701	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:24507701C>G	uc002rfe.2	-	17	2133	c.1875G>C	c.(1873-1875)ATG>ATC	p.M625I	ITSN2_uc002rff.2_Intron|ITSN2_uc002rfg.2_Missense_Mutation_p.M625I	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1	625	Potential.				endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CAGAGTCATCCATATTCCCAC	0.284		NA											34	50					0	0	0	0
UGP2	7360	broad.mit.edu	37	2	64085024	64085024	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:64085024G>T	uc002scm.2	+	3	515	c.209G>T	c.(208-210)GGG>GTG	p.G70V	UGP2_uc002scl.2_Missense_Mutation_p.G59V|UGP2_uc010ypx.1_Missense_Mutation_p.G79V	NM_006759	NP_006750	Q16851	UGPA_HUMAN	UDP-glucose pyrophosphorylase 2 isoform a	70					glycogen biosynthetic process|phosphorylation|UDP-glucose metabolic process|UDP-glucuronate biosynthetic process|xenobiotic metabolic process	cytosol	metal ion binding|protein binding|UTP:glucose-1-phosphate uridylyltransferase activity				0						CAAGAAAAGGGGCCTTCTGTG	0.403		NA											118	271					3.21e-66	5.47e-66	1	0
ANKRD53	79998	broad.mit.edu	37	2	71206951	71206951	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:71206951G>T	uc002shl.3	+	3	779	c.578G>T	c.(577-579)TGC>TTC	p.C193F	ANKRD53_uc002shk.3_Missense_Mutation_p.C193F|ANKRD53_uc002shm.3_Missense_Mutation_p.C159F	NM_001115116	NP_001108588	Q8N9V6	ANR53_HUMAN	ankyrin repeat domain 53 isoform a	193	ANK 2.										0						GCCCTCCCCTGCATCTACTAC	0.602		NA											36	76					4.39e-29	7.17e-29	1	0
REG1A	5967	broad.mit.edu	37	2	79349251	79349251	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:79349251G>T	uc002snz.2	+	4	424	c.321G>T	c.(319-321)AAG>AAT	p.K107N	REG1A_uc010ffx.1_3'UTR|REG1A_uc010ysd.1_Missense_Mutation_p.K107N	NM_002909	NP_002900	P05451	REG1A_HUMAN	regenerating islet-derived 1 alpha precursor	107	C-type lectin.				positive regulation of cell proliferation	extracellular region	growth factor activity|sugar binding				0						ACCCCAAAAAGGTAGGCTGCA	0.488		NA											41	80					1.97e-18	3.04e-18	1	0
REG3A	5068	broad.mit.edu	37	2	79386513	79386513	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:79386513G>T	uc002sod.1	-	1	274	c.19C>A	c.(19-21)CTG>ATG	p.L7M	REG3A_uc002soe.1_Missense_Mutation_p.L7M|REG3A_uc002sof.1_Missense_Mutation_p.L7M	NM_138938	NP_620355	Q06141	REG3A_HUMAN	pancreatitis-associated protein precursor	7					acute-phase response|cell proliferation|heterophilic cell-cell adhesion|multicellular organismal development	cytoplasm|extracellular space|soluble fraction	sugar binding			skin(1)	1						ACACTGGGCAGGGCCATGGGA	0.532		NA											24	83					1.38e-23	2.23e-23	1	0
CTNNA2	1496	broad.mit.edu	37	2	80874994	80874994	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:80874994C>A	uc010ysh.1	+	18	2864	c.2859C>A	c.(2857-2859)TTC>TTA	p.F953L	CTNNA2_uc010yse.1_Missense_Mutation_p.F905L|CTNNA2_uc010ysf.1_Missense_Mutation_p.F905L|CTNNA2_uc010ysg.1_Missense_Mutation_p.F860L|CTNNA2_uc010ysi.1_Missense_Mutation_p.F537L|CTNNA2_uc010ysj.1_Missense_Mutation_p.F234L	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	953					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						TGGATTCCTTCTAGGACGATA	0.343		NA											74	147					9.88e-16	1.51e-15	1	0
FABP1	2168	broad.mit.edu	37	2	88424028	88424028	+	Silent	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:88424028G>A	uc002sst.1	-	3	360	c.318C>T	c.(316-318)GGC>GGT	p.G106G	FABP1_uc002ssu.2_Silent_p.G106G	NM_001443	NP_001434	P07148	FABPL_HUMAN	fatty acid binding protein 1, liver	106					organ morphogenesis						0						TGATTATGTCGCCGTTGAGTT	0.522		NA											40	75					0	0	0	0
MITD1	129531	broad.mit.edu	37	2	99787024	99787024	+	Missense_Mutation	SNP	G	G	A	rs144672860		TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:99787024G>A	uc002szs.1	-	5	617	c.569C>T	c.(568-570)TCT>TTT	p.S190F	MRPL30_uc002szl.1_Intron|MRPL30_uc002szr.2_Intron	NM_138798	NP_620153	Q8WV92	MITD1_HUMAN	MIT, microtubule interacting and transport,	190					protein transport	late endosome membrane				large_intestine(1)|ovary(1)	2						ATGTATTGAAGAAGAGTATTG	0.313		NA											105	264					0	0	0	0
DPP10	57628	broad.mit.edu	37	2	116257182	116257182	+	Splice_Site	SNP	T	T	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:116257182T>A	uc002tla.1	+	4	823	c.366_splice	c.e4+2	p.F122_splice	DPP10_uc002tlb.1_Splice_Site_p.F72_splice|DPP10_uc002tlc.1_Splice_Site_p.F118_splice|DPP10_uc002tle.2_Splice_Site_p.F126_splice|DPP10_uc002tlf.1_Splice_Site_p.F115_splice	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long						proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						ACAACTTTTGTAAGTAATGAA	0.313		NA											21	37					0	0	0	0
IMP4	92856	broad.mit.edu	37	2	131100699	131100699	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:131100699G>T	uc002tra.1	+	2	61	c.44G>T	c.(43-45)CGC>CTC	p.R15L	CCDC115_uc002tqw.1_5'Flank|CCDC115_uc010zaf.1_5'Flank|CCDC115_uc002tqx.2_5'Flank|CCDC115_uc002tqy.1_5'Flank|CCDC115_uc002tqz.1_5'Flank	NM_033416	NP_219484	Q96G21	IMP4_HUMAN	IMP4, U3 small nucleolar ribonucleoprotein,	15	Arg-rich.				rRNA processing|translation	nucleolus|ribonucleoprotein complex	aminoacyl-tRNA ligase activity|ATP binding|protein binding			central_nervous_system(2)	2	Colorectal(110;0.1)					TACCTGTACCGCAAGGCCCGG	0.736		NA											6	12					0.000157383	0.0002127	1	0
FAM123C	205147	broad.mit.edu	37	2	131521734	131521734	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:131521734C>T	uc002trw.2	+	2	2279	c.2089C>T	c.(2089-2091)CCA>TCA	p.P697S	FAM123C_uc010fmv.2_Missense_Mutation_p.P697S|FAM123C_uc010fms.1_Missense_Mutation_p.P697S|FAM123C_uc010fmt.1_Missense_Mutation_p.P697S|FAM123C_uc010fmu.1_Missense_Mutation_p.P697S	NM_152698	NP_689911	Q8N944	F123C_HUMAN	hypothetical protein LOC205147	697										pancreas(2)|ovary(1)	3	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.13)		CGCATGGCCTCCAAGGCAAGA	0.642		NA											18	32					0	0	0	0
LRP1B	53353	broad.mit.edu	37	2	141032165	141032165	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:141032165C>A	uc002tvj.1	-	85	13942	c.12970G>T	c.(12970-12972)GTG>TTG	p.V4324L		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4324	Extracellular (Potential).|EGF-like 13.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TGGTGGCACACGTCTAGGAAA	0.353		NA								TSP Lung(27;0.18)			21	36					0.000132079	0.000179015	1	0
ARHGAP15	55843	broad.mit.edu	37	2	143986215	143986215	+	Missense_Mutation	SNP	A	A	G	rs150643555		TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:143986215A>G	uc002tvm.3	+	5	513	c.362A>G	c.(361-363)AAG>AGG	p.K121R	ARHGAP15_uc010zbl.1_Missense_Mutation_p.K121R	NM_018460	NP_060930	Q53QZ3	RHG15_HUMAN	ARHGAP15	121	PH.				regulation of cell shape|small GTPase mediated signal transduction	cytosol|membrane	protein binding|Rac GTPase activator activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.151)		AAAGAATCCAAGCAACAGGCT	0.299		NA											37	62					0	0	0	0
PRPF40A	55660	broad.mit.edu	37	2	153573823	153573823	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:153573823C>T	uc002tyi.2	-	1	99	c.86G>A	c.(85-87)GGG>GAG	p.G29E	ARL6IP6_uc002tyn.2_5'Flank|ARL6IP6_uc002tym.2_5'Flank|ARL6IP6_uc002tyo.2_5'Flank|PRPF40A_uc002tyh.3_Intron|PRPF40A_uc010zcd.1_Intron|PRPF40A_uc002tyj.2_Intron|PRPF40A_uc002tyl.1_Missense_Mutation_p.G29E	NM_017892	NP_060362	O75400	PR40A_HUMAN	formin binding protein 3	29					mRNA processing|RNA splicing	nuclear matrix|nuclear speck	protein binding				0						TCTCCGCTCCCCGTCCCCAGG	0.657		NA											10	32					0	0	0	0
SCN1A	6323	broad.mit.edu	37	2	166847776	166847776	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:166847776A>T	uc010zcz.1	-	26	5994	c.5976T>A	c.(5974-5976)GAT>GAA	p.D1992E		NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	2003						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	TGGCTTTTTCATCTTTGCCTT	0.378		NA											28	43					0	0	0	0
SCN9A	6335	broad.mit.edu	37	2	167056097	167056097	+	Silent	SNP	A	A	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:167056097A>G	uc010fpl.2	-	27	5360	c.5019T>C	c.(5017-5019)TTT>TTC	p.F1673F	uc002udp.2_Intron	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	1684	IV.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	TACTGTTGCCAAAGGTCTCAA	0.423		NA											97	277					0	0	0	0
XIRP2	129446	broad.mit.edu	37	2	168103763	168103763	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:168103763C>A	uc002udx.2	+	8	5879	c.5861C>A	c.(5860-5862)GCA>GAA	p.A1954E	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.A1779E|XIRP2_uc010fpq.2_Missense_Mutation_p.A1732E|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1779					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						GCTGTGATGGCAGGATCCTCG	0.423		NA											19	66					0.000132079	0.000179015	1	0
XIRP2	129446	broad.mit.edu	37	2	168107805	168107805	+	Silent	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:168107805G>A	uc002udx.2	+	8	9921	c.9903G>A	c.(9901-9903)GTG>GTA	p.V3301V	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Silent_p.V3126V|XIRP2_uc010fpq.2_Silent_p.V3079V|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	3126					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						AGGTTGCAGTGCCTCCTCGCC	0.438		NA											54	144					0	0	0	0
MYO3B	140469	broad.mit.edu	37	2	171260886	171260886	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:171260886C>A	uc002ufy.2	+	20	2550	c.2407C>A	c.(2407-2409)CAA>AAA	p.Q803K	MYO3B_uc002ufv.2_Missense_Mutation_p.Q790K|MYO3B_uc010fqb.1_Missense_Mutation_p.Q790K|MYO3B_uc002ufz.2_Missense_Mutation_p.Q803K|MYO3B_uc002ufw.2_RNA|MYO3B_uc002ufx.2_RNA|MYO3B_uc002ugb.2_RNA	NM_138995	NP_620482	Q8WXR4	MYO3B_HUMAN	myosin IIIB isoform 2	803	Myosin head-like.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			lung(8)|ovary(6)|skin(4)|central_nervous_system(1)	19						TCGGTTTCCCCAAGCAACTGA	0.468		NA											36	72					1.36e-19	2.14e-19	1	0
TTN	7273	broad.mit.edu	37	2	179452324	179452324	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:179452324G>A	uc010zfg.1	-	255	56232	c.56008C>T	c.(56008-56010)CGT>TGT	p.R18670C	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R12365C|TTN_uc010zfi.1_Missense_Mutation_p.R12298C|TTN_uc010zfj.1_Missense_Mutation_p.R12173C	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	19597							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAGTCATCACGGGTAGAATTG	0.413		NA											17	63					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179469614	179469614	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:179469614G>C	uc010zfg.1	-	230	46722	c.46498C>G	c.(46498-46500)CCA>GCA	p.P15500A	uc002umo.2_RNA|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.P9195A|TTN_uc010zfi.1_Missense_Mutation_p.P9128A|TTN_uc010zfj.1_Missense_Mutation_p.P9003A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	16427							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTCTTGGTGGGGATGGGCGG	0.423		NA											56	133					0	0	0	0
ZNF385B	151126	broad.mit.edu	37	2	180308165	180308165	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:180308165T>C	uc002unn.3	-	10	1832	c.1228A>G	c.(1228-1230)AAG>GAG	p.K410E	ZNF385B_uc002unj.2_Missense_Mutation_p.K308E|ZNF385B_uc002unk.2_RNA|ZNF385B_uc002unl.2_Missense_Mutation_p.K307E|ZNF385B_uc002unm.2_Missense_Mutation_p.K334E	NM_152520	NP_689733	Q569K4	Z385B_HUMAN	zinc finger protein 385B isoform 1	410						nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1			Epithelial(96;0.174)|OV - Ovarian serous cystadenocarcinoma(117;0.201)			GCCAAAGGCTTCATCATATCT	0.562		NA											8	28					0	0	0	0
ZNF385B	151126	broad.mit.edu	37	2	180383318	180383318	+	Silent	SNP	G	G	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:180383318G>T	uc002unn.3	-	5	1048	c.444C>A	c.(442-444)TCC>TCA	p.S148S	ZNF385B_uc002unj.2_Silent_p.S46S|ZNF385B_uc002unk.2_RNA|ZNF385B_uc002unl.2_Silent_p.S45S|ZNF385B_uc002unm.2_Silent_p.S72S	NM_152520	NP_689733	Q569K4	Z385B_HUMAN	zinc finger protein 385B isoform 1	148						nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1			Epithelial(96;0.174)|OV - Ovarian serous cystadenocarcinoma(117;0.201)			TTGGGGGAATGGATACTCCAA	0.343		NA											72	126					4.39e-58	7.46e-58	1	0
ZNF804A	91752	broad.mit.edu	37	2	185801142	185801142	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:185801142T>C	uc002uph.2	+	4	1613	c.1019T>C	c.(1018-1020)GTT>GCT	p.V340A		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	340						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						CTAGAGAGTGTTGTTATTAAT	0.333		NA											36	80					0	0	0	0
NAB1	4664	broad.mit.edu	37	2	191555023	191555023	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:191555023G>C	uc002usb.2	+	10	2000	c.1428G>C	c.(1426-1428)AAG>AAC	p.K476N	NAB1_uc010fsc.2_Missense_Mutation_p.K476N|NAB1_uc010fsd.2_Missense_Mutation_p.K475N|NAB1_uc002usc.2_Missense_Mutation_p.K475N|NAB1_uc010zgh.1_Missense_Mutation_p.K446N	NM_005966	NP_005957	Q13506	NAB1_HUMAN	NGFI-A binding protein 1	476					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0			OV - Ovarian serous cystadenocarcinoma(117;0.00318)|Epithelial(96;0.0405)|all cancers(119;0.109)			CCTTAGAAAAGAAAGTCATCA	0.353		NA											4	428					0	0	0	0
ANKRD44	91526	broad.mit.edu	37	2	197863757	197863757	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:197863757C>A	uc002uua.1	-	24	2541	c.2464G>T	c.(2464-2466)GCA>TCA	p.A822S	ANKRD44_uc002utz.3_Missense_Mutation_p.A554S	NM_153697	NP_710181	Q8N8A2	ANR44_HUMAN	ankyrin repeat domain 44	847	ANK 25.						protein binding			ovary(4)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(117;0.246)			TCAGCAAATGCTGCCGCATGA	0.438		NA											18	87					5.35e-07	7.51e-07	1	0
ALS2	57679	broad.mit.edu	37	2	202575803	202575803	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:202575803G>C	uc002uyo.2	-	26	4389	c.4033C>G	c.(4033-4035)CAG>GAG	p.Q1345E	ALS2_uc010ftl.2_RNA	NM_020919	NP_065970	Q96Q42	ALS2_HUMAN	alsin isoform 1	1345					cell death|endosome organization|positive regulation of Rac GTPase activity|regulation of endosome size	centrosome|cytosol|early endosome|growth cone|lamellipodium|protein complex|ruffle	protein homodimerization activity|protein serine/threonine kinase activator activity|Rab GTPase binding|Rab guanyl-nucleotide exchange factor activity|Rac guanyl-nucleotide exchange factor activity|Ran guanyl-nucleotide exchange factor activity			skin(5)|lung(1)|breast(1)	7						TCTAGTGTCTGAGTCTGTGAA	0.363		NA											27	102					0	0	0	0
PIKFYVE	200576	broad.mit.edu	37	2	209180091	209180091	+	Silent	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:209180091C>T	uc002vcz.2	+	15	2159	c.2001C>T	c.(1999-2001)ATC>ATT	p.I667I	PIKFYVE_uc010fun.1_Silent_p.I348I|PIKFYVE_uc002vcy.1_Silent_p.I611I	NM_015040	NP_055855	Q9Y2I7	FYV1_HUMAN	phosphatidylinositol-3-phosphate 5-kinase type	667					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			ovary(5)|kidney(2)|pancreas(1)|central_nervous_system(1)|skin(1)	10						TTGTCCACATCAAAAAAGTGA	0.418		NA											13	29					0	0	0	0
C2orf67	151050	broad.mit.edu	37	2	211018891	211018891	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:211018891G>C	uc002vds.2	-	2	624	c.416C>G	c.(415-417)TCA>TGA	p.S139*	C2orf67_uc002vdt.2_Nonsense_Mutation_p.S139*|C2orf67_uc002vdw.2_Nonsense_Mutation_p.S139*|C2orf67_uc002vdy.1_Nonsense_Mutation_p.S139*|C2orf67_uc002vdv.2_Nonsense_Mutation_p.S139*|C2orf67_uc002vdx.1_Nonsense_Mutation_p.S139*	NM_152519	NP_689732	A0AUZ9	CB067_HUMAN	hypothetical protein LOC151050	139										ovary(3)	3		Renal(323;0.202)		Epithelial(149;0.00435)|Lung(261;0.0529)|LUSC - Lung squamous cell carcinoma(261;0.0551)|all cancers(144;0.0696)		CGTGGTATCTGATAGAGGCTC	0.343		NA											5	73					0	0	0	0
MYL1	4632	broad.mit.edu	37	2	211163191	211163191	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:211163191G>C	uc002vec.2	-	3	386	c.257C>G	c.(256-258)CCC>CGC	p.P86R	MYL1_uc002veb.2_Missense_Mutation_p.P42R	NM_079420	NP_524144	P05976	MYL1_HUMAN	fast skeletal myosin alkali light chain 1	86					muscle filament sliding|muscle organ development	cytosol|muscle myosin complex|sarcomere	calcium ion binding|structural constituent of muscle			ovary(1)	1				Epithelial(149;0.00573)|Lung(261;0.0422)|LUSC - Lung squamous cell carcinoma(261;0.0444)|all cancers(144;0.057)		TGCATTGGTGGGATTTGTGCC	0.473		NA											57	72					0	0	0	0
ERBB4	2066	broad.mit.edu	37	2	212589868	212589868	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:212589868T>A	uc002veg.1	-	6	772	c.674A>T	c.(673-675)TAC>TTC	p.Y225F	ERBB4_uc002veh.1_Missense_Mutation_p.Y225F|ERBB4_uc010zji.1_Missense_Mutation_p.Y225F|ERBB4_uc010zjj.1_Missense_Mutation_p.Y225F|ERBB4_uc010fut.1_Missense_Mutation_p.Y225F	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	225	Cys-rich.|Extracellular (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		GTCACTGACGTAAGGTCCGTA	0.493		NA								TSP Lung(8;0.080)			41	47					0	0	0	0
FN1	2335	broad.mit.edu	37	2	216269263	216269263	+	Silent	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:216269263G>A	uc002vfa.2	-	20	3368	c.3102C>T	c.(3100-3102)ACC>ACT	p.T1034T	FN1_uc002vfb.2_Silent_p.T1034T|FN1_uc002vfc.2_Silent_p.T1034T|FN1_uc002vfd.2_Silent_p.T1034T|FN1_uc002vfe.2_Silent_p.T1034T|FN1_uc002vff.2_Silent_p.T1034T|FN1_uc002vfg.2_Silent_p.T1034T|FN1_uc002vfh.2_Silent_p.T1034T|FN1_uc002vfi.2_Silent_p.T1034T|FN1_uc002vfj.2_Silent_p.T1034T	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	1034	|Fibronectin type-III 5.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GTCCTCTTCGGGTAAGGCCCA	0.547		NA											45	50					0	0	0	0
RNPEPL1	57140	broad.mit.edu	37	2	241514540	241514540	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:241514540G>A	uc002vzi.2	+	7	1282	c.689G>A	c.(688-690)CGC>CAC	p.R230H	RNPEPL1_uc010fzf.2_Missense_Mutation_p.R136H|RNPEPL1_uc002vzj.2_5'Flank	NM_018226	NP_060696	Q9HAU8	RNPL1_HUMAN	arginyl aminopeptidase (aminopeptidase B)-like	230					leukotriene biosynthetic process|proteolysis		aminopeptidase activity|metallopeptidase activity|zinc ion binding			large_intestine(1)|skin(1)	2		all_epithelial(40;1.13e-11)|Breast(86;0.000169)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.204)|Melanoma(123;0.238)		Epithelial(32;3.05e-31)|all cancers(36;8.2e-29)|OV - Ovarian serous cystadenocarcinoma(60;8.55e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.12e-06)|Lung(119;0.00168)|Colorectal(34;0.005)|LUSC - Lung squamous cell carcinoma(224;0.00813)|COAD - Colon adenocarcinoma(134;0.0322)		GACCCACAGCGCTTTGATGAC	0.632		NA											81	75					0	0	0	0
HDLBP	3069	broad.mit.edu	37	2	242187504	242187504	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr2:242187504G>T	uc002waz.2	-	14	1873	c.1645C>A	c.(1645-1647)CAA>AAA	p.Q549K	HDLBP_uc002wba.2_Missense_Mutation_p.Q549K|HDLBP_uc002wbb.2_Missense_Mutation_p.Q501K	NM_203346	NP_976221	Q00341	VIGLN_HUMAN	high density lipoprotein binding protein	549	KH 6.				cholesterol metabolic process|lipid transport	cytoplasm|high-density lipoprotein particle|nucleus|plasma membrane	lipid binding|protein binding|RNA binding			breast(3)|skin(1)	4		all_cancers(19;7.77e-41)|all_epithelial(40;1.74e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.0121)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;8.13e-34)|all cancers(36;4.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;2.34e-15)|Kidney(56;3.72e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.76e-08)|BRCA - Breast invasive adenocarcinoma(100;3.38e-06)|Lung(119;0.000109)|LUSC - Lung squamous cell carcinoma(224;0.000964)|Colorectal(34;0.0132)|COAD - Colon adenocarcinoma(134;0.0928)		TCACTTTTTTGTGCTGGGTCT	0.408		NA											43	37					1.85e-21	2.94e-21	1	0
C20orf194	25943	broad.mit.edu	37	20	3324338	3324338	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr20:3324338T>A	uc002wii.2	-	9	881	c.830A>T	c.(829-831)CAT>CTT	p.H277L	C20orf194_uc002wij.3_5'Flank|C20orf194_uc002wik.2_Intron|C20orf194_uc010gay.1_RNA	NM_001009984	NP_001009984	Q5TEA3	CT194_HUMAN	hypothetical protein LOC25943	277											0						TTCAGTTATATGGCTAGAGAT	0.388		NA											292	252					0	0	0	0
SLC23A2	9962	broad.mit.edu	37	20	4865411	4865411	+	Silent	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr20:4865411G>A	uc002wlg.1	-	8	1005	c.630C>T	c.(628-630)CCC>CCT	p.P210P	SLC23A2_uc010zqr.1_Intron|SLC23A2_uc002wlh.1_Silent_p.P210P|SLC23A2_uc002wli.2_Silent_p.P209P	NM_005116	NP_005107	Q9UGH3	S23A2_HUMAN	solute carrier family 23 (nucleobase	210					L-ascorbic acid metabolic process|molecular hydrogen transport|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|transepithelial L-ascorbic acid transport	apical plasma membrane|integral to plasma membrane|membrane fraction	nucleobase transmembrane transporter activity|sodium-dependent L-ascorbate transmembrane transporter activity|sodium-dependent multivitamin transmembrane transporter activity			ovary(2)	2						CTCGGATCCGGGGATACCAGA	0.418		NA											54	180					0	0	0	0
INSM1	3642	broad.mit.edu	37	20	20350277	20350277	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr20:20350277C>T	uc002wrx.2	+	1	1513	c.1366C>T	c.(1366-1368)CAG>TAG	p.Q456*		NM_002196	NP_002187	Q01101	INSM1_HUMAN	insulinoma-associated 1	456	C2H2-type 4.				endocrine pancreas development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0649)		CAAGGGCGCTCAGGAGCGCCA	0.716		NA											14	37					0	0	0	0
C20orf185	359710	broad.mit.edu	37	20	31652345	31652345	+	Silent	SNP	G	G	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr20:31652345G>T	uc002wym.1	+	7	735	c.735G>T	c.(733-735)CTG>CTT	p.L245L		NM_182658	NP_872599	P59826	LPLC3_HUMAN	antimicrobial peptide RYA3 precursor	245					innate immune response	cytoplasm|extracellular region	lipid binding|protein binding			ovary(4)	4						ACATAGAACTGGACATCAACG	0.587		NA											28	67					7.26e-15	1.1e-14	1	0
SAMHD1	25939	broad.mit.edu	37	20	35559189	35559189	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr20:35559189T>C	uc002xgh.1	-	5	729	c.599A>G	c.(598-600)CAG>CGG	p.Q200R		NM_015474	NP_056289	Q9Y3Z3	SAMH1_HUMAN	SAM domain- and HD domain-containing protein 1	200	HD.				defense response to virus|innate immune response|regulation of innate immune response	nucleus	metal ion binding|phosphoric diester hydrolase activity				0		Myeloproliferative disorder(115;0.00878)				TCCAGCAATCTGAACACAGAG	0.413		NA											64	141					0	0	0	0
RTEL1	51750	broad.mit.edu	37	20	62321524	62321524	+	Silent	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr20:62321524C>T	uc002yfu.1	+	25	2569	c.2226C>T	c.(2224-2226)ATC>ATT	p.I742I	RTEL1_uc011abc.1_RNA|RTEL1_uc002yft.1_Silent_p.I742I|RTEL1_uc011abd.1_Silent_p.I766I|RTEL1_uc011abe.1_Silent_p.I519I|RTEL1_uc002yfw.2_RNA|RTEL1_uc002yfx.1_5'UTR	NM_016434	NP_057518	Q9NZ71	RTEL1_HUMAN	regulator of telomere elongation helicase 1	742					DNA repair|regulation of double-strand break repair via homologous recombination|telomere maintenance	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding				0	all_cancers(38;6.47e-12)|all_epithelial(29;3.75e-13)		Epithelial(9;1.25e-09)|all cancers(9;5.13e-09)|BRCA - Breast invasive adenocarcinoma(10;7.26e-05)|OV - Ovarian serous cystadenocarcinoma(5;0.00223)|Colorectal(105;0.107)			GCCATGTCATCCGAGACGTGG	0.617		NA											9	99					0	0	0	0
ZNF512B	57473	broad.mit.edu	37	20	62591451	62591451	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr20:62591451C>G	uc002yhl.1	-	17	2523	c.2469G>C	c.(2467-2469)AGG>AGC	p.R823S		NM_020713	NP_065764	Q96KM6	Z512B_HUMAN	zinc finger protein 512B	823					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					AGTCCTGGCTCCTGTGTTTGG	0.572		NA											6	122					0	0	0	0
MRAP	56246	broad.mit.edu	37	21	33671361	33671361	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr21:33671361G>C	uc002ypj.2	+	3	266	c.79G>C	c.(79-81)GAC>CAC	p.D27H	MRAP_uc002ypk.2_Missense_Mutation_p.D27H|MRAP_uc011ado.1_Intron|MRAP_uc002ypl.2_Missense_Mutation_p.D27H	NM_178817	NP_848932	Q8TCY5	MRAP_HUMAN	melanocortin 2 receptor accessory protein	27	Cytoplasmic (Potential).				positive regulation of cAMP biosynthetic process|protein localization at cell surface	endoplasmic reticulum|integral to membrane|perinuclear region of cytoplasm|plasma membrane	corticotropin hormone receptor binding|type 1 melanocortin receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding|type 5 melanocortin receptor binding				0						CATTCCCGTGGACGAGAAGAA	0.582		NA											8	91					0	0	0	0
SYNJ1	8867	broad.mit.edu	37	21	34003713	34003713	+	Silent	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr21:34003713G>A	uc002yqh.2	-	32	4431	c.4431C>T	c.(4429-4431)ATC>ATT	p.I1477I	SYNJ1_uc011ads.1_3'UTR|SYNJ1_uc002yqf.2_3'UTR|SYNJ1_uc002yqg.2_Silent_p.I1391I|SYNJ1_uc002yqi.2_3'UTR|SYNJ1_uc002yqe.3_Silent_p.I63I	NM_003895	NP_003886	O43426	SYNJ1_HUMAN	synaptojanin 1 isoform a	1438	Pro-rich.						inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			ovary(4)|skin(1)	5						GGAAAGGACTGATAGTAACGG	0.468		NA											19	67					0	0	0	0
DSCAM	1826	broad.mit.edu	37	21	42080487	42080487	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr21:42080487G>A	uc002yyq.1	-	2	706	c.254C>T	c.(253-255)CCC>CTC	p.P85L	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	85	Extracellular (Potential).|Ig-like C2-type 1.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				AGGAGGGAAGGGGAAAATTTG	0.498		NA											5	110					0	0	0	0
XBP1	7494	broad.mit.edu	37	22	29191483	29191483	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr22:29191483C>G	uc011akl.1	-	6	859	c.811G>C	c.(811-813)GAG>CAG	p.E271Q	XBP1_uc003aec.2_Missense_Mutation_p.E92Q|XBP1_uc003aed.2_3'UTR|XBP1_uc003aef.2_Missense_Mutation_p.E92Q	NM_001079539	NP_001073007	P17861	XBP1_HUMAN	X-box binding protein 1 isoform XBP1(S)	Error:Variant_position_missing_in_P17861_after_alignment					immune response	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1						CTCTCTGTCTCAGAGGGTATC	0.463		NA											4	39					0	0	0	0
THOC5	8563	broad.mit.edu	37	22	29940543	29940543	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr22:29940543C>T	uc003afr.2	-	4	481	c.146G>A	c.(145-147)GGC>GAC	p.G49D	THOC5_uc003afs.2_Missense_Mutation_p.G49D|THOC5_uc003aft.2_Missense_Mutation_p.G49D|THOC5_uc003afu.2_Missense_Mutation_p.G49D|THOC5_uc010gvo.2_5'UTR|THOC5_uc003afv.1_Missense_Mutation_p.G49D|THOC5_uc003afw.1_5'Flank	NM_001002878	NP_001002878	Q13769	THOC5_HUMAN	THO complex 5	49	Interaction with THOC7.|Interaction with CSF1R (By similarity).				intronless viral mRNA export from host nucleus|monocyte differentiation|mRNA processing|primitive hemopoiesis|RNA splicing	cytoplasm|intermediate filament cytoskeleton|THO complex part of transcription export complex	protein binding|RNA binding			breast(3)	3						ATAGTCTCTGCCAGGGTCCCG	0.527		NA											6	157					0	0	0	0
OSBP2	23762	broad.mit.edu	37	22	31091189	31091189	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr22:31091189C>T	uc003aiy.1	+	1	397	c.293C>T	c.(292-294)TCG>TTG	p.S98L	OSBP2_uc011ala.1_Intron|OSBP2_uc010gwc.1_Intron|OSBP2_uc003aix.1_Missense_Mutation_p.S98L|OSBP2_uc011alb.1_Missense_Mutation_p.S98L|OSBP2_uc003aiz.1_Missense_Mutation_p.S98L	NM_030758	NP_110385	Q969R2	OSBP2_HUMAN	oxysterol binding protein 2 isoform a	98					lipid transport	membrane	lipid binding			breast(1)|skin(1)	2						GGGCAGCCATCGGAACTGCTG	0.667		NA											9	76					0	0	0	0
GRAMD4	23151	broad.mit.edu	37	22	47033814	47033814	+	Silent	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr22:47033814C>T	uc003bhx.2	+	2	279	c.240C>T	c.(238-240)ATC>ATT	p.I80I	GRAMD4_uc010had.2_Silent_p.I19I	NM_015124	NP_055939	Q6IC98	GRAM4_HUMAN	death-inducing-protein	80					apoptosis	integral to membrane|mitochondrial membrane				ovary(1)	1		Breast(42;0.00571)|Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|BRCA - Breast invasive adenocarcinoma(115;0.166)		TGAATGAGATCAAAGGTCACC	0.498		NA											6	225					0	0	0	0
PLXNB2	23654	broad.mit.edu	37	22	50718166	50718166	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr22:50718166T>A	uc003bkv.3	-	27	4388	c.4282A>T	c.(4282-4284)ATC>TTC	p.I1428F	PLXNB2_uc003bkt.1_Missense_Mutation_p.I220F|PLXNB2_uc003bku.1_Missense_Mutation_p.I413F	NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	1428	Cytoplasmic (Potential).				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		TGATGTTTGATGGCCTTGAAG	0.622		NA											116	223					0	0	0	0
SAPS2	9701	broad.mit.edu	37	22	50860746	50860746	+	Silent	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr22:50860746C>T	uc003blb.1	+	10	1331	c.909C>T	c.(907-909)AGC>AGT	p.S303S	SAPS2_uc003bky.1_Silent_p.S303S|SAPS2_uc003bkz.1_Silent_p.S303S|SAPS2_uc003blc.2_Silent_p.S303S|SAPS2_uc003bla.1_Silent_p.S304S|uc011arw.1_5'Flank	NM_014678	NP_055493	O75170	PP6R2_HUMAN	SAPS domain family, member 2	303						cytoplasm|intracellular membrane-bounded organelle	protein binding				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.222)		TCAGCAGCAGCGTACTACACG	0.592		NA											11	167					0	0	0	0
ITPR1	3708	broad.mit.edu	37	3	4829703	4829703	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr3:4829703G>A	uc003bqa.2	+	49	6892	c.6544G>A	c.(6544-6546)GAG>AAG	p.E2182K	ITPR1_uc010hca.1_Missense_Mutation_p.E2167K|ITPR1_uc011asu.1_Intron|ITPR1_uc003bqc.2_Missense_Mutation_p.E1152K	NM_001099952	NP_001093422	Q14643	ITPR1_HUMAN	inositol 1,4,5-triphosphate receptor, type 1	2230	Cytoplasmic (Potential).				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			lung(7)|breast(5)|ovary(4)|large_intestine(1)|liver(1)|skin(1)|kidney(1)|pancreas(1)	21				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		CCTAACCAAGGAGTCAAAACT	0.388		NA											5	38					0	0	0	0
SYN2	6854	broad.mit.edu	37	3	12208791	12208791	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr3:12208791G>C	uc003bwm.2	+	12	1202	c.1038G>C	c.(1036-1038)CAG>CAC	p.Q346H	SYN2_uc003bwl.1_Missense_Mutation_p.Q346H|SYN2_uc003bwn.2_Missense_Mutation_p.Q20H	NM_133625	NP_598328	Q92777	SYN2_HUMAN	synapsin II isoform IIa	346					neurotransmitter secretion	synaptic vesicle	ATP binding|ligase activity			ovary(1)|central_nervous_system(1)	2						TGCTGGAGCAGATTGCCATGT	0.517		NA											6	31					0	0	0	0
SLC4A7	9497	broad.mit.edu	37	3	27463267	27463267	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr3:27463267C>T	uc003cdv.2	-	9	1314	c.1243G>A	c.(1243-1245)GAT>AAT	p.D415N	SLC4A7_uc011awu.1_RNA|SLC4A7_uc011awv.1_RNA|SLC4A7_uc003cdu.3_Missense_Mutation_p.D296N|SLC4A7_uc011aww.1_Missense_Mutation_p.D424N|SLC4A7_uc011awx.1_Missense_Mutation_p.D411N|SLC4A7_uc011awy.1_Missense_Mutation_p.D407N|SLC4A7_uc011awz.1_RNA|SLC4A7_uc011axa.1_Missense_Mutation_p.D296N|SLC4A7_uc011axb.1_Missense_Mutation_p.D411N|SLC4A7_uc010hfl.2_Intron|SLC4A7_uc003cdw.2_Missense_Mutation_p.D291N	NM_003615	NP_003606	Q9Y6M7	S4A7_HUMAN	solute carrier family 4, sodium bicarbonate	415	Extracellular (Potential).					apical plasma membrane|basolateral plasma membrane|integral to membrane|stereocilium	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|central_nervous_system(1)|skin(1)	5						AAATTCATATCAACCTATTGA	0.353		NA											50	33					0	0	0	0
ANO10	55129	broad.mit.edu	37	3	43596801	43596801	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr3:43596801G>C	uc003cmv.2	-	10	1808	c.1637C>G	c.(1636-1638)TCA>TGA	p.S546*	ANO10_uc011azs.1_Nonsense_Mutation_p.S546*|ANO10_uc003cmw.2_Nonsense_Mutation_p.S480*|ANO10_uc010hil.2_Nonsense_Mutation_p.S356*|ANO10_uc011azt.1_Nonsense_Mutation_p.S435*	NM_018075	NP_060545	Q9NW15	ANO10_HUMAN	transmembrane protein 16K	546	Cytoplasmic (Potential).				cell death	chloride channel complex	chloride channel activity			ovary(2)	2						TGAAGGTTCTGAGAATGGACG	0.353		NA											8	112					0	0	0	0
LTF	4057	broad.mit.edu	37	3	46482938	46482938	+	Silent	SNP	C	C	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr3:46482938C>A	uc003cpq.2	-	14	1730	c.1692G>T	c.(1690-1692)GTG>GTT	p.V564V	LTF_uc003fzr.2_Silent_p.V520V|LTF_uc010hjh.2_Silent_p.V562V|LTF_uc003cpr.2_Silent_p.V551V	NM_002343	NP_002334	P02788	TRFL_HUMAN	lactotransferrin precursor	564	Transferrin-like 2.				cellular iron ion homeostasis|defense response to bacterium|humoral immune response|iron ion transport	extracellular region|stored secretory granule	ferric iron binding|heparin binding|protein binding|serine-type endopeptidase activity			central_nervous_system(2)|ovary(1)|lung(1)	4				all cancers(1;7.55e-14)|GBM - Glioblastoma multiforme(1;2.1e-09)|Epithelial(1;9.25e-07)|Colorectal(1;3.81e-05)|BRCA - Breast invasive adenocarcinoma(193;0.00129)|COAD - Colon adenocarcinoma(1;0.00308)|KIRC - Kidney renal clear cell carcinoma(197;0.0205)|Kidney(197;0.0242)|OV - Ovarian serous cystadenocarcinoma(275;0.089)	Pefloxacin(DB00487)	TGACATCTTTCACAAATGCAA	0.403		NA											60	27					2.04e-18	3.16e-18	1	0
NBEAL2	23218	broad.mit.edu	37	3	47049354	47049354	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr3:47049354C>G	uc003cqp.2	+	49	7735	c.7556C>G	c.(7555-7557)TCA>TGA	p.S2519*	NBEAL2_uc010hjm.1_Nonsense_Mutation_p.S1896*|NBEAL2_uc010hjn.1_Nonsense_Mutation_p.S885*|NBEAL2_uc010hjo.1_Nonsense_Mutation_p.S79*	NM_015175	NP_055990	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	2519	WD 3.						binding			ovary(1)	1		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		TACCTCATCTCAGGCTCCCGG	0.632		NA											12	26					0	0	0	0
NBEAL2	23218	broad.mit.edu	37	3	47049787	47049787	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr3:47049787C>G	uc003cqp.2	+	51	7913	c.7734C>G	c.(7732-7734)ATC>ATG	p.I2578M	NBEAL2_uc010hjm.1_Missense_Mutation_p.I1955M|NBEAL2_uc010hjn.1_Missense_Mutation_p.I944M|NBEAL2_uc010hjo.1_Missense_Mutation_p.I138M	NM_015175	NP_055990	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	2578	WD 4.						binding			ovary(1)	1		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		GAACTGTGATCATACACACTG	0.602		NA											9	27					0	0	0	0
ZMYND10	51364	broad.mit.edu	37	3	50380755	50380755	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr3:50380755C>G	uc003dag.1	-	5	639	c.493G>C	c.(493-495)GAC>CAC	p.D165H	RASSF1_uc003dad.1_5'Flank|RASSF1_uc003dae.1_5'Flank|RASSF1_uc010hlk.1_5'Flank|RASSF1_uc003daf.1_5'Flank|RASSF1_uc011bdq.1_5'Flank|ZMYND10_uc010hll.1_Missense_Mutation_p.D165H|ZMYND10_uc003dah.1_Missense_Mutation_p.D86H|ZMYND10_uc010hlm.1_Missense_Mutation_p.D122H	NM_015896	NP_056980	O75800	ZMY10_HUMAN	zinc finger, MYND domain-containing 10	165						cytoplasm	protein binding|zinc ion binding			lung(4)|ovary(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		GGGTTGCTGTCCTGGGATCCC	0.617		NA								TSP Lung(30;0.18)			21	51					0	0	0	0
LRIG1	26018	broad.mit.edu	37	3	66460596	66460596	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr3:66460596T>C	uc003dmx.2	-	7	906	c.892A>G	c.(892-894)ATT>GTT	p.I298V	LRIG1_uc010hnz.2_Missense_Mutation_p.I38V|LRIG1_uc010hoa.2_Missense_Mutation_p.I298V	NM_015541	NP_056356	Q96JA1	LRIG1_HUMAN	leucine-rich repeats and immunoglobulin-like	298	Extracellular (Potential).|LRR 10.					integral to membrane				skin(3)|ovary(2)	5		Lung NSC(201;0.0101)		BRCA - Breast invasive adenocarcinoma(55;0.00047)		TTGCGGTGAATGCGAGCGATG	0.567		NA											141	137					0	0	0	0
FRMD4B	23150	broad.mit.edu	37	3	69239050	69239050	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr3:69239050C>T	uc003dnv.2	-	18	2058	c.1768G>A	c.(1768-1770)GAT>AAT	p.D590N	FRMD4B_uc003dnw.2_Intron|FRMD4B_uc003dnu.2_Missense_Mutation_p.D242N|FRMD4B_uc011bga.1_Missense_Mutation_p.D434N	NM_015123	NP_055938	Q9Y2L6	FRM4B_HUMAN	FERM domain containing 4B	590						cytoplasm|cytoskeleton	binding			ovary(3)|central_nervous_system(1)	4		Lung NSC(201;0.0138)|Prostate(884;0.11)		BRCA - Breast invasive adenocarcinoma(55;0.000201)|Epithelial(33;0.00141)|LUSC - Lung squamous cell carcinoma(21;0.00999)|Lung(16;0.0182)		CACTTACGATCATCATAGGTG	0.313		NA											16	27					0	0	0	0
OR5K3	403277	broad.mit.edu	37	3	98109533	98109533	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr3:98109533G>C	uc011bgw.1	+	1	24	c.24G>C	c.(22-24)TTG>TTC	p.L8F		NM_001005516	NP_001005516	A6NET4	OR5K3_HUMAN	olfactory receptor, family 5, subfamily K,	8	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						ATCACTCCTTGATAGCTGAGT	0.388		NA											24	73					0	0	0	0
CD200R1	131450	broad.mit.edu	37	3	112647682	112647682	+	Silent	SNP	C	C	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr3:112647682C>A	uc003dzk.1	-	4	914	c.681G>T	c.(679-681)CTG>CTT	p.L227L	CD200R1_uc003dzj.1_Silent_p.L250L|CD200R1_uc011bhx.1_Silent_p.L205L	NM_170780	NP_740750	Q8TD46	MO2R1_HUMAN	CD200 receptor 1 isoform d	227	Ig-like C2-type.|Extracellular (Potential).				interspecies interaction between organisms|regulation of immune response	extracellular region|integral to membrane|plasma membrane	receptor activity			ovary(2)|pancreas(1)	3						GCTCTATGTACAGACTCTTGT	0.378		NA											20	40					3.62e-10	5.3e-10	1	0
TIGIT	201633	broad.mit.edu	37	3	114026751	114026751	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr3:114026751C>T	uc003ebg.1	+	4	542	c.508C>T	c.(508-510)CTC>TTC	p.L170F		NM_173799	NP_776160	Q495A1	TIGIT_HUMAN	T cell immunoreceptor with Ig and ITIM domains	170	Cytoplasmic (Potential).				negative regulation of interleukin-12 production|negative regulation of T cell activation|positive regulation of interleukin-10 production	cell surface|integral to membrane|plasma membrane	protein binding			central_nervous_system(1)	1						GAAGAAAGCCCTCAGAATCCA	0.418		NA											21	111					0	0	0	0
CASR	846	broad.mit.edu	37	3	122003103	122003103	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr3:122003103G>T	uc003eev.3	+	7	2674	c.2302G>T	c.(2302-2304)GGC>TGC	p.G768C	CASR_uc003eew.3_Missense_Mutation_p.G778C	NM_000388	NP_000379	P41180	CASR_HUMAN	calcium-sensing receptor precursor	768	Extracellular (Potential).				anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(2)|upper_aerodigestive_tract(1)	7				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	GTGCCACGAGGGCTCCCTCAT	0.587		NA											22	44					1.11e-12	1.65e-12	1	0
KALRN	8997	broad.mit.edu	37	3	124390618	124390618	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr3:124390618C>T	uc003ehg.2	+	48	6939	c.6812C>T	c.(6811-6813)GCG>GTG	p.A2271V	KALRN_uc003ehi.2_Missense_Mutation_p.A612V|KALRN_uc003ehk.2_Missense_Mutation_p.A574V|KALRN_uc011bjz.1_Missense_Mutation_p.A363V	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	2270					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						TCTGTTCCTGCGGGCTCAGAG	0.567		NA											20	151					0	0	0	0
CLRN1	7401	broad.mit.edu	37	3	150690259	150690259	+	Silent	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr3:150690259C>T	uc003eyk.1	-	1	528	c.237G>A	c.(235-237)AGG>AGA	p.R79R	CLRN1OS_uc011bny.1_Intron|CLRN1OS_uc003eyl.2_5'Flank	NM_174878	NP_777367	P58418	CLRN1_HUMAN	clarin 1 isoform a	79					equilibrioception|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	integral to membrane					0			LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			ACCGAAAGGGCCTTGCTCCCA	0.473		NA											56	164					0	0	0	0
IFT80	57560	broad.mit.edu	37	3	160099294	160099294	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr3:160099294C>G	uc011boy.1	-	3	689	c.256G>C	c.(256-258)GAT>CAT	p.D86H	IFT80_uc003fda.2_Intron|IFT80_uc003fdb.1_5'UTR|IFT80_uc003fdd.1_5'UTR|IFT80_uc003fde.1_5'UTR	NM_020800	NP_065851	Q9P2H3	IFT80_HUMAN	WD repeat domain 56	86						cilium axoneme|microtubule basal body				ovary(1)	1			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			AACTTACCATCAGAACTTGTG	0.328		NA											15	106					0	0	0	0
SMC4	10051	broad.mit.edu	37	3	160120573	160120573	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr3:160120573C>A	uc003fdh.2	+	4	541	c.428C>A	c.(427-429)TCA>TAA	p.S143*	IFT80_uc003fda.2_Intron|SMC4_uc003fdf.1_RNA|SMC4_uc003fdg.1_Nonsense_Mutation_p.S143*|SMC4_uc010hwc.1_Intron|SMC4_uc003fdi.2_Nonsense_Mutation_p.S118*|SMC4_uc003fdj.2_Nonsense_Mutation_p.S143*|SMC4_uc010hwd.2_Nonsense_Mutation_p.S143*|uc011boz.1_5'Flank|MIR15B_hsa-mir-15b|MI0000438_5'Flank|uc003fdk.2_5'Flank|MIR16-2_hsa-mir-16-2|MI0000115_5'Flank	NM_001002800	NP_001002800	Q9NTJ3	SMC4_HUMAN	SMC4 structural maintenance of chromosomes	143					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	ATP binding|protein heterodimerization activity			ovary(1)|breast(1)	2			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			AAAAAACTCTCAGTATTAATA	0.323		NA											8	262					0.000274275	0.000368916	1	0
MYNN	55892	broad.mit.edu	37	3	169492266	169492266	+	Silent	SNP	C	C	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr3:169492266C>G	uc003fft.2	+	2	612	c.183C>G	c.(181-183)GTC>GTG	p.V61V	MYNN_uc011bpm.1_Intron|MYNN_uc003ffu.2_Silent_p.V61V|MYNN_uc003ffv.2_5'UTR|MYNN_uc010hwo.2_Silent_p.V61V	NM_018657	NP_061127	Q9NPC7	MYNN_HUMAN	myoneurin	61	BTB.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1	all_cancers(22;9.55e-22)|all_epithelial(15;2.04e-26)|all_lung(20;5.05e-16)|Lung NSC(18;2.19e-15)|Ovarian(172;0.000223)|Breast(254;0.197)		Epithelial(2;4.03e-64)|all cancers(2;2.19e-58)|Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00676)			AGAACAATGTCTTTCTTGATC	0.388		NA											5	380					0	0	0	0
NAALADL2	254827	broad.mit.edu	37	3	174814867	174814867	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr3:174814867A>T	uc003fit.2	+	2	418	c.331A>T	c.(331-333)ACA>TCA	p.T111S	NAALADL2_uc003fiu.1_Missense_Mutation_p.T104S	NM_207015	NP_996898	Q58DX5	NADL2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	111	Cytoplasmic (Potential).				proteolysis	integral to membrane	peptidase activity			pancreas(1)	1	Ovarian(172;0.0102)	all_cancers(1;0.0272)|all_epithelial(1;0.0553)	OV - Ovarian serous cystadenocarcinoma(80;9.26e-28)	Colorectal(1;1.66e-10)|COAD - Colon adenocarcinoma(1;2.1e-07)|STAD - Stomach adenocarcinoma(1;0.00261)|READ - Rectum adenocarcinoma(3;0.0284)		TACCCATTATACACGATCTGC	0.388		NA											58	233					0	0	0	0
NAALADL2	254827	broad.mit.edu	37	3	174951960	174951960	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr3:174951960C>T	uc003fit.2	+	3	872	c.785C>T	c.(784-786)TCA>TTA	p.S262L	NAALADL2_uc003fiu.1_Missense_Mutation_p.S255L|NAALADL2_uc010hwy.1_Missense_Mutation_p.S84L	NM_207015	NP_996898	Q58DX5	NADL2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	262	Extracellular (Potential).				proteolysis	integral to membrane	peptidase activity			pancreas(1)	1	Ovarian(172;0.0102)	all_cancers(1;0.0272)|all_epithelial(1;0.0553)	OV - Ovarian serous cystadenocarcinoma(80;9.26e-28)	Colorectal(1;1.66e-10)|COAD - Colon adenocarcinoma(1;2.1e-07)|STAD - Stomach adenocarcinoma(1;0.00261)|READ - Rectum adenocarcinoma(3;0.0284)		CTGCTCTATTCATATGCAGCC	0.428		NA											26	146					0	0	0	0
PIK3CA	5290	broad.mit.edu	37	3	178921521	178921521	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr3:178921521A>G	uc003fjk.2	+	5	1160	c.1003A>G	c.(1003-1005)AGA>GGA	p.R335G		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	335					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TAGTGCACTCAGAATAAAAAT	0.313		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			40	317					0	0	0	0
MCCC1	56922	broad.mit.edu	37	3	182790247	182790247	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr3:182790247G>A	uc003fle.2	-	5	535	c.398C>T	c.(397-399)TCA>TTA	p.S133L	MCCC1_uc010hxi.2_RNA|MCCC1_uc011bqo.1_RNA|MCCC1_uc003flf.2_Intron|MCCC1_uc003flg.2_Missense_Mutation_p.S24L|MCCC1_uc011bqp.1_Missense_Mutation_p.S86L|MCCC1_uc011bqq.1_Missense_Mutation_p.S24L	NM_020166	NP_064551	Q96RQ3	MCCA_HUMAN	methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)	133	Biotin carboxylation.				biotin metabolic process|leucine catabolic process	mitochondrial inner membrane|mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|methylcrotonoyl-CoA carboxylase activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(143;1.84e-14)|Ovarian(172;0.0355)		all cancers(12;1.8e-44)|Epithelial(37;3.23e-38)|LUSC - Lung squamous cell carcinoma(7;5.04e-25)|Lung(8;5.03e-23)|OV - Ovarian serous cystadenocarcinoma(80;5.07e-21)		Biotin(DB00121)	CATGTTTTCTGAGAGAAAACC	0.383		NA											14	228					0	0	0	0
PAK2	5062	broad.mit.edu	37	3	196509690	196509690	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr3:196509690C>T	uc003fwy.3	+	2	495	c.173C>T	c.(172-174)TCA>TTA	p.S58L		NM_002577	NP_002568	Q13177	PAK2_HUMAN	p21-activated kinase 2	58					axon guidance|cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of protein kinase activity|peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of apoptosis|regulation of defense response to virus by virus|regulation of growth|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|nucleus|perinuclear region of cytoplasm|plasma membrane	ATP binding|identical protein binding|protein kinase binding|protein serine/threonine kinase activity|protein tyrosine kinase activator activity			ovary(1)|lung(1)	2	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.07e-23)|all cancers(36;6.38e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.5e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00405)		TCCATATTCTCAGGCACAGAG	0.413		NA											32	377					0	0	0	0
DLG1	1739	broad.mit.edu	37	3	196846384	196846384	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr3:196846384C>G	uc003fxo.3	-	13	1472	c.1282G>C	c.(1282-1284)GAT>CAT	p.D428H	DLG1_uc011bub.1_Missense_Mutation_p.D312H|DLG1_uc011buc.1_Missense_Mutation_p.D312H|DLG1_uc011bud.1_Missense_Mutation_p.D111H|DLG1_uc003fxn.3_Missense_Mutation_p.D428H|DLG1_uc011bue.1_Missense_Mutation_p.D395H|DLG1_uc010ial.2_Missense_Mutation_p.D428H|DLG1_uc011buf.1_Intron|DLG1_uc003fxp.2_RNA|DLG1_uc010iam.1_Missense_Mutation_p.D395H|DLG1_uc010ian.2_Missense_Mutation_p.D295H	NM_001098424	NP_001091894	Q12959	DLG1_HUMAN	discs, large homolog 1 isoform 1	428					actin filament organization|axon guidance|cell-cell adhesion|cortical actin cytoskeleton organization|endothelial cell proliferation|establishment or maintenance of cell polarity|interspecies interaction between organisms|mitotic cell cycle G1/S transition checkpoint|negative regulation of mitotic cell cycle|protein localization in plasma membrane|synaptic transmission|tight junction assembly	basolateral plasma membrane|cytosol|endoplasmic reticulum membrane|immunological synapse|MPP7-DLG1-LIN7 complex|nucleus|postsynaptic density|postsynaptic membrane|sarcolemma|tight junction	cytoskeletal protein binding|guanylate kinase activity|L27 domain binding|phosphatase binding|phosphoprotein phosphatase activity|potassium channel regulator activity|protein binding|protein C-terminus binding|protein kinase binding			ovary(3)	3	all_cancers(143;6.22e-10)|Ovarian(172;0.0418)|Breast(254;0.0589)	Lung NSC(153;0.133)	Epithelial(36;3.23e-24)|all cancers(36;2.15e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.0148)		ACATGGTTATCAACAGGCTGA	0.388		NA											13	146					0	0	0	0
LPHN3	23284	broad.mit.edu	37	4	62778453	62778453	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr4:62778453G>A	uc010ihh.2	+	10	2059	c.1886G>A	c.(1885-1887)CGC>CAC	p.R629H	LPHN3_uc003hcq.3_Missense_Mutation_p.R629H|LPHN3_uc003hct.2_Intron|LPHN3_uc003hcs.1_Intron	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						AAAAGAGAGCGCTCTTGCAGA	0.363		NA											50	51					0	0	0	0
SLC4A4	8671	broad.mit.edu	37	4	72205125	72205125	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr4:72205125G>C	uc003hfy.2	+	4	409	c.292G>C	c.(292-294)GAG>CAG	p.E98Q	SLC4A4_uc010iic.2_Missense_Mutation_p.E98Q|SLC4A4_uc010iib.2_Missense_Mutation_p.E98Q|SLC4A4_uc003hfz.2_Missense_Mutation_p.E98Q|SLC4A4_uc003hgc.3_Missense_Mutation_p.E54Q|SLC4A4_uc003hga.2_5'UTR|SLC4A4_uc003hgb.3_Missense_Mutation_p.E54Q	NM_001098484	NP_001091954	Q9Y6R1	S4A4_HUMAN	solute carrier family 4, sodium bicarbonate	98	Cytoplasmic (Potential).					basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|kidney(1)|skin(1)	5			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			CATCTTGGGAGAGGAGGATGA	0.552		NA											23	212					0	0	0	0
ADAMTS3	9508	broad.mit.edu	37	4	73280591	73280591	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr4:73280591T>A	uc003hgk.1	-	4	639	c.602A>T	c.(601-603)TAC>TTC	p.Y201F		NM_014243	NP_055058	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1	201					collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TGATCTCTTGTAGACAACATG	0.373		NA											44	48					0	0	0	0
FRAS1	80144	broad.mit.edu	37	4	79285132	79285132	+	Silent	SNP	C	C	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr4:79285132C>G	uc003hlb.2	+	22	3086	c.2646C>G	c.(2644-2646)CTC>CTG	p.L882L	FRAS1_uc003hkw.2_Silent_p.L882L	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	882	FU 10.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						ACACCAACCTCGTGCTGTCCC	0.527		NA											4	29					0	0	0	0
DMP1	1758	broad.mit.edu	37	4	88584164	88584164	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr4:88584164C>T	uc003hqv.2	+	6	1338	c.1234C>T	c.(1234-1236)CTC>TTC	p.L412F	DMP1_uc003hqw.2_Missense_Mutation_p.L396F	NM_004407	NP_004398	Q13316	DMP1_HUMAN	dentin matrix acidic phosphoprotein 1 isoform 1	412					biomineral tissue development|ossification	cytoplasm|nucleus|proteinaceous extracellular matrix	calcium ion binding|integrin binding			pancreas(1)|skin(1)	2		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.227)		OV - Ovarian serous cystadenocarcinoma(123;0.000516)		CAGTGAGAGCCTCAACTTCTC	0.572		NA											58	59					0	0	0	0
CENPE	1062	broad.mit.edu	37	4	104068734	104068734	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr4:104068734T>C	uc003hxb.1	-	29	4003	c.3913A>G	c.(3913-3915)ATG>GTG	p.M1305V	CENPE_uc003hxc.1_Missense_Mutation_p.M1280V	NM_001813	NP_001804	Q02224	CENPE_HUMAN	centromere protein E	1305	Potential.				blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			ovary(5)|breast(4)	9				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		AGTTCATTCATTGTTTCCTGA	0.388		NA											44	40					0	0	0	0
COL25A1	84570	broad.mit.edu	37	4	109822296	109822296	+	Silent	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr4:109822296C>T	uc003hze.1	-	13	1344	c.813G>A	c.(811-813)CAG>CAA	p.Q271Q	COL25A1_uc003hzg.2_Silent_p.Q271Q|COL25A1_uc003hzd.2_RNA|COL25A1_uc003hzf.2_Silent_p.Q52Q	NM_198721	NP_942014	Q9BXS0	COPA1_HUMAN	collagen, type XXV, alpha 1 isoform 1	271	Extracellular (Potential).|Collagen-like 3.					collagen|extracellular space	beta-amyloid binding|heparin binding			ovary(2)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000173)		GTATTCCATTCTGTCCTACTG	0.348		NA											15	50					0	0	0	0
KIAA1109	84162	broad.mit.edu	37	4	123155982	123155982	+	Silent	SNP	A	A	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr4:123155982A>G	uc003ieh.2	+	25	3423	c.3378A>G	c.(3376-3378)AAA>AAG	p.K1126K	KIAA1109_uc003iei.1_Silent_p.K879K|KIAA1109_uc010ins.1_Silent_p.K469K	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	1126					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						GTAGAAACAAATGTGGTTGTC	0.393		NA											50	54					0	0	0	0
SPATA5	166378	broad.mit.edu	37	4	123855336	123855336	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr4:123855336G>T	uc003iez.3	+	5	663	c.590G>T	c.(589-591)GGG>GTG	p.G197V	SPATA5_uc003iey.2_Missense_Mutation_p.G196V	NM_145207	NP_660208	Q8NB90	SPAT5_HUMAN	spermatogenesis associated 5	197					cell differentiation|multicellular organismal development|spermatogenesis	mitochondrion	ATP binding|nucleoside-triphosphatase activity				0						CGAGTGAAAGGGGCAGATGGC	0.463		NA											30	42					1.81e-10	2.65e-10	1	0
HSPA4L	22824	broad.mit.edu	37	4	128741604	128741604	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr4:128741604G>C	uc003ifm.2	+	14	1949	c.1696G>C	c.(1696-1698)GAC>CAC	p.D566H	HSPA4L_uc010iny.1_Missense_Mutation_p.D525H|HSPA4L_uc011cgr.1_Missense_Mutation_p.D533H	NM_014278	NP_055093	O95757	HS74L_HUMAN	heat shock 70kDa protein 4-like	566					protein folding|response to unfolded protein	cytoplasm|nucleus	ATP binding|protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4						AGACAAACAAGACCGATTAAA	0.338		NA											14	27					0	0	0	0
HSPA4L	22824	broad.mit.edu	37	4	128743942	128743942	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr4:128743942G>T	uc003ifm.2	+	15	2084	c.1831G>T	c.(1831-1833)GAT>TAT	p.D611Y	HSPA4L_uc011cgr.1_Missense_Mutation_p.D578Y	NM_014278	NP_055093	O95757	HS74L_HUMAN	heat shock 70kDa protein 4-like	611					protein folding|response to unfolded protein	cytoplasm|nucleus	ATP binding|protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4						GATCATGCAAGATAAGTTAGA	0.274		NA											16	26					4.75e-09	6.86e-09	1	0
HSPA4L	22824	broad.mit.edu	37	4	128748493	128748493	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr4:128748493G>C	uc003ifm.2	+	17	2333	c.2080G>C	c.(2080-2082)GAG>CAG	p.E694Q	HSPA4L_uc011cgr.1_Missense_Mutation_p.E661Q	NM_014278	NP_055093	O95757	HS74L_HUMAN	heat shock 70kDa protein 4-like	694					protein folding|response to unfolded protein	cytoplasm|nucleus	ATP binding|protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4						GAAGTACATGGAGCATGAAGA	0.318		NA											21	53					0	0	0	0
MFSD8	256471	broad.mit.edu	37	4	128865017	128865017	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr4:128865017G>C	uc003ifp.2	-	5	492	c.329C>G	c.(328-330)TCC>TGC	p.S110C	MFSD8_uc011cgu.1_Missense_Mutation_p.S65C|MFSD8_uc011cgv.1_Missense_Mutation_p.S110C|MFSD8_uc011cgw.1_RNA|MFSD8_uc011cgx.1_Missense_Mutation_p.S65C	NM_152778	NP_689991	Q8NHS3	MFSD8_HUMAN	major facilitator superfamily domain containing	110	Helical; (Potential).				cell death|transmembrane transport	integral to membrane|lysosomal membrane				ovary(1)|liver(1)	2						AATCAAGATGGAGACAATAAG	0.423		NA											3	75					0	0	0	0
NPY1R	4886	broad.mit.edu	37	4	164247211	164247211	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr4:164247211C>T	uc003iqm.1	-	2	762	c.496G>A	c.(496-498)GCT>ACT	p.A166T	NPY1R_uc011cjj.1_Intron	NM_000909	NP_000900	P25929	NPY1R_HUMAN	neuropeptide Y receptor Y1	166	Helical; Name=4; (Potential).				inhibition of adenylate cyclase activity by G-protein signaling pathway|outflow tract morphogenesis	integral to plasma membrane	protein binding			lung(1)|pancreas(1)	2	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				GAAGCCACAGCAAGGACCCAA	0.433		NA											30	39					0	0	0	0
GPM6A	2823	broad.mit.edu	37	4	176573001	176573001	+	Silent	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr4:176573001C>T	uc003iuf.2	-	4	1329	c.525G>A	c.(523-525)TTG>TTA	p.L175L	GPM6A_uc011ckj.1_Silent_p.L168L|GPM6A_uc003iug.2_Silent_p.L175L|GPM6A_uc003iuh.2_Silent_p.L164L	NM_201591	NP_963885	P51674	GPM6A_HUMAN	glycoprotein M6A isoform 2	175	Extracellular (Potential).					cell surface|integral to membrane					0		Breast(14;7.35e-05)|Melanoma(52;0.00909)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;9.21e-19)|Epithelial(43;3.01e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.02e-09)|STAD - Stomach adenocarcinoma(60;0.00083)|GBM - Glioblastoma multiforme(59;0.00168)|LUSC - Lung squamous cell carcinoma(193;0.0388)		GACGAAGGTCCAAGCAGAGAT	0.438		NA											10	141					0	0	0	0
FAT1	2195	broad.mit.edu	37	4	187521277	187521277	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr4:187521277C>A	uc003izf.2	-	22	12066	c.11878G>T	c.(11878-11880)GGA>TGA	p.G3960*	FAT1_uc003ize.2_5'Flank	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	3960	Extracellular (Potential).|Laminin G-like.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						TGCCTTGTTCCCTGCTGACGG	0.483		NA								HNSCC(5;0.00058)			60	70					6.1e-20	9.6e-20	1	0
SEMA5A	9037	broad.mit.edu	37	5	9066745	9066745	+	Missense_Mutation	SNP	C	C	A	rs140646095		TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr5:9066745C>A	uc003jek.2	-	17	2799	c.2087G>T	c.(2086-2088)TGC>TTC	p.C696F		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	696	TSP type-1 3.|Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						GTTGGTGTTGCAAGACTGGTA	0.537		NA											78	178					4.63e-29	7.55e-29	1	0
CTNND2	1501	broad.mit.edu	37	5	11023077	11023077	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr5:11023077G>A	uc003jfa.1	-	17	2948	c.2803C>T	c.(2803-2805)CGA>TGA	p.R935*	CTNND2_uc010itt.2_Nonsense_Mutation_p.R844*|CTNND2_uc011cmy.1_Nonsense_Mutation_p.R598*|CTNND2_uc011cmz.1_Nonsense_Mutation_p.R502*|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Nonsense_Mutation_p.R527*	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	935					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						ACTAGGTCTCGCATGGCGTAT	0.512		NA											63	74					0	0	0	0
CTNND2	1501	broad.mit.edu	37	5	11346514	11346514	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr5:11346514G>T	uc003jfa.1	-	9	1743	c.1598C>A	c.(1597-1599)CCG>CAG	p.P533Q	CTNND2_uc010itt.2_Missense_Mutation_p.P442Q|CTNND2_uc011cmy.1_Missense_Mutation_p.P196Q|CTNND2_uc011cmz.1_Missense_Mutation_p.P100Q|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Missense_Mutation_p.P100Q	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	533					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						ATCAATGGACGGGGACCTGGC	0.493		NA											105	163					3.01e-58	5.12e-58	1	0
MYO10	4651	broad.mit.edu	37	5	16783479	16783479	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr5:16783479C>A	uc003jft.3	-	5	1035	c.567G>T	c.(565-567)AAG>AAT	p.K189N	MYO10_uc003jfu.2_Missense_Mutation_p.K156N	NM_012334	NP_036466	Q9HD67	MYO10_HUMAN	myosin X	189	Myosin head-like.				axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			ovary(2)|pancreas(1)	3						CACAGGATGTCTTCTCCTTTA	0.378		NA											9	23					1.77e-08	2.53e-08	1	0
CDH9	1007	broad.mit.edu	37	5	26890642	26890642	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr5:26890642G>T	uc003jgs.1	-	8	1454	c.1285C>A	c.(1285-1287)CGT>AGT	p.R429S	CDH9_uc011cnv.1_Missense_Mutation_p.R22S	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	429	Extracellular (Potential).|Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						CCAAAAATACGGTCCATATCA	0.403		NA											33	92					1.41e-09	2.05e-09	1	0
AGXT2	64902	broad.mit.edu	37	5	35039554	35039554	+	Silent	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr5:35039554C>T	uc003jjf.2	-	3	316	c.237G>A	c.(235-237)ACG>ACA	p.T79T	AGXT2_uc011com.1_Silent_p.T79T|AGXT2_uc011con.1_5'UTR	NM_031900	NP_114106	Q9BYV1	AGT2_HUMAN	alanine-glyoxylate aminotransferase 2 precursor	79					glyoxylate metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	mitochondrial matrix	(R)-3-amino-2-methylpropionate-pyruvate transaminase activity|alanine-glyoxylate transaminase activity|pyridoxal phosphate binding			ovary(3)|skin(1)	4	all_lung(31;4.52e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)	GBM - Glioblastoma multiforme(108;0.181)	Glycine(DB00145)|L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)|Pyruvic acid(DB00119)	GGAAATATGCCGTCACCACAG	0.473		NA											38	102					0	0	0	0
HEATR7B2	133558	broad.mit.edu	37	5	41055916	41055916	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr5:41055916G>T	uc003jmj.3	-	10	1451	c.961C>A	c.(961-963)CAA>AAA	p.Q321K	HEATR7B2_uc003jmi.3_Intron	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	321	HEAT 4.						binding			ovary(6)|central_nervous_system(2)	8						CTTCTTACTTGTTCATCAAAA	0.403		NA											35	122					9.78e-24	1.58e-23	1	0
FST	10468	broad.mit.edu	37	5	52778754	52778754	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr5:52778754G>A	uc003jpd.2	+	2	157	c.130G>A	c.(130-132)GTC>ATC	p.V44I	FST_uc003jpc.2_Missense_Mutation_p.V44I	NM_013409	NP_037541	P19883	FST_HUMAN	follistatin isoform FST344 precursor	44	TB.				hemopoietic progenitor cell differentiation|negative regulation of activin receptor signaling pathway|negative regulation of follicle-stimulating hormone secretion|negative regulation of transcription from RNA polymerase II promoter|positive regulation of hair follicle development	extracellular region	activin binding|protein binding|signal transducer activity				0		Ovarian(174;1.78e-06)|Lung NSC(810;3.55e-06)|Breast(144;4.08e-05)				CCGCTGCCAGGTCCTGTACAA	0.617		NA									OREG0016608	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	61					0	0	0	0
MAP1B	4131	broad.mit.edu	37	5	71501008	71501008	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr5:71501008G>A	uc003kbw.3	+	7	7590	c.7349G>A	c.(7348-7350)AGC>AAC	p.S2450N		NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	2450						microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		GTTTTAGCAAGCAGCAGCACA	0.468		NA											10	211					0	0	0	0
AP3B1	8546	broad.mit.edu	37	5	77311320	77311320	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr5:77311320C>A	uc003kfj.2	-	26	3170	c.3045G>T	c.(3043-3045)CAG>CAT	p.Q1015H		NM_003664	NP_003655	O00203	AP3B1_HUMAN	adaptor-related protein complex 3, beta 1	1015					endocytosis|melanosome organization	clathrin coated vesicle membrane|Golgi apparatus|membrane coat	protein phosphatase binding|protein transporter activity			central_nervous_system(1)	1		all_lung(232;0.000397)|Lung NSC(167;0.00106)|Ovarian(174;0.0105)|Prostate(461;0.215)		OV - Ovarian serous cystadenocarcinoma(54;8.23e-47)|Epithelial(54;2.74e-41)|all cancers(79;4.8e-36)		GAGTGAAATTCTGTGGTGCAG	0.393		NA							Hermansky-Pudlak_syndrome				74	34					2.05e-37	3.42e-37	1	0
ACOT12	134526	broad.mit.edu	37	5	80640770	80640770	+	Silent	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr5:80640770G>A	uc003khl.3	-	8	919	c.864C>T	c.(862-864)TAC>TAT	p.Y288Y	RNU5E_uc011cto.1_Intron	NM_130767	NP_570123	Q8WYK0	ACO12_HUMAN	acyl-CoA thioesterase 12	288	Acyl coenzyme A hydrolase 2.				acyl-CoA metabolic process|fatty acid metabolic process	cytosol	acetyl-CoA hydrolase activity|carboxylesterase activity			ovary(1)|kidney(1)	2		Lung NSC(167;0.0176)|all_lung(232;0.0205)|Ovarian(174;0.135)		OV - Ovarian serous cystadenocarcinoma(54;1.37e-45)|Epithelial(54;1.25e-39)|all cancers(79;5.01e-34)		CAGCAGCATTGTAAATGAGAA	0.488		NA											49	118					0	0	0	0
GPR98	84059	broad.mit.edu	37	5	90106677	90106677	+	Silent	SNP	T	T	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr5:90106677T>A	uc003kju.2	+	74	15696	c.15600T>A	c.(15598-15600)GCT>GCA	p.A5200A	GPR98_uc003kjt.2_Silent_p.A2906A|GPR98_uc003kjw.2_Silent_p.A861A	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	5200	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GCACACCTGCTGTGTCTGAAA	0.478		NA											55	116					0	0	0	0
GPR98	84059	broad.mit.edu	37	5	90106682	90106682	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr5:90106682C>A	uc003kju.2	+	74	15701	c.15605C>A	c.(15604-15606)TCT>TAT	p.S5202Y	GPR98_uc003kjt.2_Missense_Mutation_p.S2908Y|GPR98_uc003kjw.2_Missense_Mutation_p.S863Y	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	5202	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CCTGCTGTGTCTGAAAAGCCT	0.468		NA											57	111					3.32e-32	5.49e-32	1	0
NUDT12	83594	broad.mit.edu	37	5	102890447	102890447	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr5:102890447C>T	uc003koi.2	-	5	1165	c.1072G>A	c.(1072-1074)GAG>AAG	p.E358K	NUDT12_uc011cvb.1_Missense_Mutation_p.E340K	NM_031438	NP_113626	Q9BQG2	NUD12_HUMAN	nudix-type motif 12	358	Nudix box.|Nudix hydrolase.					nucleus|peroxisome	metal ion binding|NAD+ diphosphatase activity				0		all_cancers(142;6.38e-08)|all_epithelial(76;1.99e-10)|Prostate(80;0.0138)|Lung NSC(167;0.0212)|Colorectal(57;0.0247)|all_lung(232;0.0283)|Ovarian(225;0.0423)		Epithelial(69;9.3e-13)|COAD - Colon adenocarcinoma(37;0.0221)		TTACCAGGCTCAATAAATCCA	0.318		NA											23	71					0	0	0	0
KCNN2	3781	broad.mit.edu	37	5	113831600	113831600	+	Silent	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr5:113831600C>T	uc003kqo.2	+	8	1918	c.1461C>T	c.(1459-1461)AAC>AAT	p.N487N	KCNN2_uc003kqp.2_Silent_p.N139N|KCNN2_uc010jcg.2_RNA|uc003kqr.1_Intron	NM_021614	NP_067627	Q9H2S1	KCNN2_HUMAN	small conductance calcium-activated potassium	487	Calmodulin-binding (By similarity).					integral to membrane	calmodulin binding|small conductance calcium-activated potassium channel activity			ovary(2)	2		all_cancers(142;2.86e-05)|all_epithelial(76;9.33e-06)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Breast(839;0.159)|Lung NSC(810;0.174)|all_lung(232;0.206)		OV - Ovarian serous cystadenocarcinoma(64;1.89e-08)|Epithelial(69;2.04e-08)|all cancers(49;3.74e-06)|COAD - Colon adenocarcinoma(37;0.142)|Colorectal(14;0.195)		AGACCCAGAACATCATGTATG	0.408		NA											40	125					0	0	0	0
DMXL1	1657	broad.mit.edu	37	5	118576160	118576160	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr5:118576160G>C	uc003ksd.2	+	41	8816	c.8635G>C	c.(8635-8637)GTC>CTC	p.V2879L	DMXL1_uc010jcl.1_Missense_Mutation_p.V2900L|DMXL1_uc010jcm.1_RNA|DMXL1_uc003kse.1_Missense_Mutation_p.V53L	NM_005509	NP_005500	Q9Y485	DMXL1_HUMAN	Dmx-like 1	2879										ovary(2)	2		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		CAATAGTTTAGTCCATGGTAA	0.289		NA											42	102					0	0	0	0
PCDHA11	56138	broad.mit.edu	37	5	140250129	140250129	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr5:140250129G>C	uc003lia.2	+	1	2299	c.1441G>C	c.(1441-1443)GCG>CCG	p.A481P	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc011dae.1_Missense_Mutation_p.A481P	NM_018902	NP_061725	Q9Y5I1	PCDAB_HUMAN	protocadherin alpha 11 isoform 1 precursor	481	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCGCGGGACGCGGACGCGCA	0.667		NA											8	225					0	0	0	0
PCDHAC2	56134	broad.mit.edu	37	5	140347910	140347910	+	Missense_Mutation	SNP	C	C	T	rs148804197		TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr5:140347910C>T	uc003lii.2	+	1	1799	c.1559C>T	c.(1558-1560)TCC>TTC	p.S520F	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Intron|PCDHA13_uc003lif.2_Intron|PCDHAC1_uc003lih.2_Intron|PCDHAC2_uc011dag.1_Missense_Mutation_p.S520F	NM_018899	NP_061722	Q9Y5I4	PCDC2_HUMAN	protocadherin alpha subfamily C, 2 isoform 1	520	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCAGTCACCTCCTATGTCTCC	0.507		NA											6	102					0	0	0	0
PCDHB11	56125	broad.mit.edu	37	5	140581330	140581330	+	Silent	SNP	C	C	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr5:140581330C>G	uc003liy.2	+	1	1983	c.1983C>G	c.(1981-1983)CTC>CTG	p.L661L	PCDHB11_uc011daj.1_Silent_p.L296L	NM_018931	NP_061754	Q9Y5F2	PCDBB_HUMAN	protocadherin beta 11 precursor	661	Extracellular (Potential).|Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGCAAGTGCTCCTGGTGGACG	0.706		NA											9	162					0	0	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140719457	140719457	+	Silent	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr5:140719457C>T	uc003ljk.1	+	1	1104	c.919C>T	c.(919-921)CTA>TTA	p.L307L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc011dao.1_Silent_p.L307L	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	307	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CATAAAAGATCTAGATTATGA	0.423		NA											12	255					0	0	0	0
PCDHGA10	56106	broad.mit.edu	37	5	140795002	140795002	+	Silent	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr5:140795002C>T	uc003lkl.1	+	1	2260	c.2260C>T	c.(2260-2262)CTG>TTG	p.L754L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc011day.1_Silent_p.L754L|PCDHGB7_uc003lkm.2_5'Flank|PCDHGB7_uc003lkn.1_5'Flank	NM_018913	NP_061736	Q9Y5H3	PCDGA_HUMAN	protocadherin gamma subfamily A, 10 isoform 1	754	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCGGGCTTTCCTGCAGACCTA	0.627		NA											83	122					0	0	0	0
SH3RF2	153769	broad.mit.edu	37	5	145439601	145439601	+	Silent	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr5:145439601C>T	uc003lnt.2	+	9	1966	c.1728C>T	c.(1726-1728)CTC>CTT	p.L576L	SH3RF2_uc011dbl.1_Silent_p.L576L|SH3RF2_uc011dbm.1_Silent_p.L61L|SH3RF2_uc003lnu.2_Silent_p.L67L|SH3RF2_uc011dbn.1_Silent_p.L67L|SH3RF2_uc011dbo.1_Silent_p.L33L	NM_152550	NP_689763	Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	576							ligase activity|protein phosphatase 1 binding|zinc ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGCCTGCCCTCACGGGGGAGC	0.632		NA											38	74					0	0	0	0
GABRA1	2554	broad.mit.edu	37	5	161324208	161324208	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr5:161324208C>A	uc010jiw.2	+	11	1619	c.1151C>A	c.(1150-1152)CCG>CAG	p.P384Q	GABRA1_uc010jix.2_Missense_Mutation_p.P384Q|GABRA1_uc010jiy.2_Missense_Mutation_p.P384Q|GABRA1_uc003lyx.3_Missense_Mutation_p.P384Q|GABRA1_uc010jiz.2_Missense_Mutation_p.P384Q|GABRA1_uc010jja.2_Missense_Mutation_p.P384Q|GABRA1_uc010jjb.2_Missense_Mutation_p.P384Q	NM_000806	NP_000797	P14867	GBRA1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha	384	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|pancreas(1)	3	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.228)	Alprazolam(DB00404)|Butabarbital(DB00237)|Butalbital(DB00241)|Butethal(DB01353)|Chlordiazepoxide(DB00475)|Clobazam(DB00349)|Clonazepam(DB01068)|Clorazepate(DB00628)|Desflurane(DB01189)|Diazepam(DB00829)|Enflurane(DB00228)|Ethanol(DB00898)|Ethchlorvynol(DB00189)|Etomidate(DB00292)|Flumazenil(DB01205)|Flurazepam(DB00690)|Halazepam(DB00801)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Lorazepam(DB00186)|Meprobamate(DB00371)|Metharbital(DB00463)|Methohexital(DB00474)|Methoxyflurane(DB01028)|Methylphenobarbital(DB00849)|Methyprylon(DB01107)|Midazolam(DB00683)|Nitrazepam(DB01595)|Oxazepam(DB00842)|Pentobarbital(DB00312)|Phenobarbital(DB01174)|Picrotoxin(DB00466)|Prazepam(DB01588)|Primidone(DB00794)|Progabide(DB00837)|Propofol(DB00818)|Quazepam(DB01589)|Secobarbital(DB00418)|Sevoflurane(DB01236)|Talbutal(DB00306)|Thiamylal(DB01154)|Thiopental(DB00599)|Topiramate(DB00273)|Zaleplon(DB00962)|Zolpidem(DB00425)	AGGGGCGACCCGGGCTTAGCC	0.458		NA											85	113					2.03e-29	3.32e-29	1	0
ZFP2	80108	broad.mit.edu	37	5	178358636	178358636	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr5:178358636A>T	uc003mjn.1	+	5	831	c.322A>T	c.(322-324)AGC>TGC	p.S108C	ZFP2_uc010jky.2_Missense_Mutation_p.S108C|ZFP2_uc010jkx.1_Missense_Mutation_p.S108C	NM_030613	NP_085116	Q6ZN57	ZFP2_HUMAN	zinc finger protein 2 homolog	108	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(89;0.000639)|all_epithelial(37;0.000109)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.00655)|GBM - Glioblastoma multiforme(465;0.0302)|OV - Ovarian serous cystadenocarcinoma(192;0.0615)|Epithelial(171;0.111)		TAATCAGTGCAGCAAAACCTT	0.373		NA											23	33					0	0	0	0
ZNF354C	30832	broad.mit.edu	37	5	178506641	178506641	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr5:178506641A>G	uc003mju.2	+	5	1323	c.1208A>G	c.(1207-1209)CAG>CGG	p.Q403R		NM_014594	NP_055409	Q86Y25	Z354C_HUMAN	zinc finger protein 354C	403	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_cancers(89;0.00065)|all_epithelial(37;0.000153)|Renal(175;0.000159)|Lung NSC(126;0.00175)|all_lung(126;0.00309)	all_cancers(40;0.19)|all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.247)		ATCGAACATCAGCGAATTCAC	0.408		NA											3	158					0	0	0	0
HIST1H3D	8351	broad.mit.edu	37	6	26197326	26197326	+	Silent	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr6:26197326C>T	uc003ngv.2	-	2	550	c.153G>A	c.(151-153)GAG>GAA	p.E51E	HIST1H2BF_uc003ngx.2_5'Flank	NM_003530	NP_003521	P68431	H31_HUMAN	histone cluster 1, H3d	51					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding				0		all_hematologic(11;0.196)				AGCGGCGGATCTCGCGCAGAG	0.632		NA											49	107					0	0	0	0
BTN3A2	11118	broad.mit.edu	37	6	26370714	26370714	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr6:26370714G>T	uc010jqh.1	+	5	857	c.598G>T	c.(598-600)GGC>TGC	p.G200C	BTN3A2_uc003nho.1_Missense_Mutation_p.G198C|BTN3A2_uc003nhp.2_Missense_Mutation_p.G200C|BTN3A2_uc011dkd.1_Missense_Mutation_p.G158C|BTN3A2_uc011dke.1_Missense_Mutation_p.G177C|BTN3A2_uc010jqi.1_Missense_Mutation_p.G198C	NM_007047	NP_008978	P78410	BT3A2_HUMAN	butyrophilin, subfamily 3, member A2 precursor	200	Extracellular (Potential).					integral to membrane					0						AGATGGAGTGGGCCTATATGA	0.567		NA											67	196					2.18e-39	3.65e-39	1	0
SCAND3	114821	broad.mit.edu	37	6	28541503	28541503	+	Silent	SNP	A	A	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr6:28541503A>C	uc003nlo.2	-	4	2781	c.2163T>G	c.(2161-2163)CCT>CCG	p.P721P		NM_052923	NP_443155	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	721					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			ovary(1)	1						tcccttcttcaggataacttc	0		NA											4	34					0	0	0	0
RNF39	80352	broad.mit.edu	37	6	30043359	30043359	+	Missense_Mutation	SNP	C	C	G	rs141667762		TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr6:30043359C>G	uc003npe.2	-	1	270	c.208G>C	c.(208-210)GAT>CAT	p.D70H	RNF39_uc003npd.2_Missense_Mutation_p.D70H	NM_025236	NP_079512	Q9H2S5	RNF39_HUMAN	ring finger protein 39 isoform 1	70						cytoplasm	zinc ion binding				0						TCGGGCGCATCCATGGAAAGC	0.701		NA											19	33					0	0	0	0
AGER	177	broad.mit.edu	37	6	32148952	32148952	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr6:32148952C>T	uc003oal.1	-	11	1207	c.1183G>A	c.(1183-1185)GAG>AAG	p.E395K	AGER_uc003oak.1_Missense_Mutation_p.E124K|AGER_uc003oar.2_Missense_Mutation_p.E294K|AGER_uc011dpm.1_Missense_Mutation_p.E285K|AGER_uc011dpn.1_3'UTR|AGER_uc010jtv.1_3'UTR|AGER_uc011dpo.1_3'UTR|AGER_uc003oam.1_RNA|AGER_uc003oan.1_Silent_p.*343*|AGER_uc003oap.1_Missense_Mutation_p.E411K|AGER_uc003oat.1_3'UTR|AGER_uc003oao.1_RNA|AGER_uc003oaq.1_Missense_Mutation_p.E381K|AGER_uc010jtw.1_RNA|AGER_uc003oas.1_3'UTR|AGER_uc003oau.1_3'UTR	NM_001136	NP_001127	Q15109	RAGE_HUMAN	advanced glycosylation end product-specific	395	Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|inflammatory response|innate immune response|neuron projection development|positive regulation of NF-kappaB transcription factor activity	integral to plasma membrane	S100 alpha binding|transmembrane receptor activity			breast(1)	1						TCGCCTGCCTCAGGTTCCTCC	0.557		NA											7	438					0	0	0	0
TAP2	6891	broad.mit.edu	37	6	32797792	32797792	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr6:32797792G>C	uc003occ.2	-	9	1741	c.1710C>G	c.(1708-1710)AGC>AGG	p.S570R	TAP2_uc011dqf.1_Missense_Mutation_p.S570R|TAP2_uc003ocb.1_Missense_Mutation_p.S570R|TAP2_uc003ocd.2_Missense_Mutation_p.S570R	NM_018833	NP_061313	Q03519	TAP2_HUMAN	transporter 2, ATP-binding cassette, sub-family	570	ABC transporter.|Cytoplasmic (Potential).				antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent|antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent|antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent|cytosol to ER transport|intracellular transport of viral proteins in host cell|peptide antigen transport|positive regulation of antigen processing and presentation of peptide antigen via MHC class I|positive regulation of T cell mediated cytotoxicity	nucleus|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|peptide antigen-transporting ATPase activity|TAP1 binding|TAP2 binding|tapasin binding				0						CATCTTCGCAGCTCTGCAGCC	0.537		NA											61	142					0	0	0	0
ZBTB22	9278	broad.mit.edu	37	6	33283712	33283712	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr6:33283712G>C	uc003oeb.2	-	2	1134	c.982C>G	c.(982-984)CTG>GTG	p.L328V	TAPBP_uc003odx.1_5'Flank|TAPBP_uc010jus.1_5'Flank|TAPBP_uc003ody.2_5'Flank|TAPBP_uc003odz.2_5'Flank|TAPBP_uc010jut.1_5'Flank|TAPBP_uc011drc.1_5'Flank|ZBTB22_uc010juu.2_Missense_Mutation_p.L328V	NM_005453	NP_005444	O15209	ZBT22_HUMAN	zinc finger and BTB domain containing 22	328					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GTCAACACCAGATCTTCCTCC	0.557		NA											16	166					0	0	0	0
DAXX	1616	broad.mit.edu	37	6	33287564	33287564	+	Silent	SNP	G	G	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr6:33287564G>C	uc003oec.2	-	6	1737	c.1533C>G	c.(1531-1533)GGC>GGG	p.G511G	ZBTB22_uc003oeb.2_5'Flank|ZBTB22_uc010juu.2_5'Flank|DAXX_uc011drd.1_Silent_p.G436G|DAXX_uc011dre.1_Silent_p.G523G|DAXX_uc003oed.2_Silent_p.G511G	NM_001350	NP_001341	Q9UER7	DAXX_HUMAN	death-domain associated protein isoform a	511	Asp/Glu-rich (acidic).|Interaction with MAP3K5.|Necessary for interaction with USP7.				activation of JUN kinase activity|androgen receptor signaling pathway|apoptosis|induction of apoptosis via death domain receptors|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|regulation of protein ubiquitination|transcription, DNA-dependent	chromosome, centromeric region|cytosol|nucleolus|PML body	androgen receptor binding|heat shock protein binding|p53 binding|protein homodimerization activity|protein N-terminus binding|receptor signaling protein activity|transcription factor binding|ubiquitin protein ligase binding			pancreas(18)|ovary(2)|skin(2)|prostate(1)	23						TGATCTGTTTGCCAGGTTCCA	0.502		NA	Mis|F|N		Pancreatic neuroendocrine tumors								9	118					0	0	0	0
PPARD	5467	broad.mit.edu	37	6	35378951	35378951	+	Silent	SNP	C	C	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr6:35378951C>G	uc003okm.2	+	3	396	c.87C>G	c.(85-87)CTC>CTG	p.L29L	PPARD_uc003okl.2_Silent_p.L29L|PPARD_uc003okn.2_Silent_p.L29L|PPARD_uc011dtb.1_Intron|PPARD_uc011dtc.1_Silent_p.L29L|PPARD_uc010jvv.1_RNA	NM_006238	NP_006229	Q03181	PPARD_HUMAN	peroxisome proliferative activated receptor,	29					apoptosis|axon ensheathment|cholesterol metabolic process|decidualization|embryo implantation|fatty acid beta-oxidation|fatty acid transport|generation of precursor metabolites and energy|glucose metabolic process|glucose transport|negative regulation of transcription from RNA polymerase II promoter|positive regulation of fat cell differentiation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	drug binding|linoleic acid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)	1					Icosapent(DB00159)|Sulindac(DB00605)|Treprostinil(DB00374)	CCCCAGAGCTCAATGGGGGAC	0.627		NA											16	68					0	0	0	0
MAPK13	5603	broad.mit.edu	37	6	36106682	36106682	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr6:36106682G>A	uc003ols.2	+	11	966	c.868G>A	c.(868-870)GAG>AAG	p.E290K	MAPK13_uc003olt.2_RNA	NM_002754	NP_002745	O15264	MK13_HUMAN	mitogen-activated protein kinase 13	290	Protein kinase.				cell cycle|intracellular protein kinase cascade|nerve growth factor receptor signaling pathway|positive regulation of interleukin-6 production|Ras protein signal transduction|response to stress		ATP binding|MAP kinase activity|protein binding			breast(2)|central_nervous_system(1)	3						GAAGATGCTGGAGCTAGACGT	0.672		NA											22	81					0	0	0	0
DNAH8	1769	broad.mit.edu	37	6	38759381	38759381	+	Silent	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr6:38759381C>T	uc003ooe.1	+	19	2781	c.2181C>T	c.(2179-2181)GCC>GCT	p.A727A		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						AGGAGATAGCCAAAACTGTGT	0.353		NA											20	37					0	0	0	0
TREM1	54210	broad.mit.edu	37	6	41250265	41250265	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr6:41250265C>G	uc003oqf.1	-	2	338	c.274G>C	c.(274-276)GAT>CAT	p.D92H	TREM1_uc003oqg.1_Missense_Mutation_p.D92H	NM_018643	NP_061113	Q9NP99	TREM1_HUMAN	triggering receptor expressed on myeloid cells 1	92	Extracellular (Potential).|Ig-like V-type.				blood coagulation|humoral immune response|intracellular signal transduction|leukocyte migration	extracellular region|integral to membrane|intracellular|plasma membrane	receptor activity			breast(1)	1	Ovarian(28;0.0327)|Colorectal(47;0.196)				Glutathione(DB00143)	AAACCATGATCATGGTAGTCT	0.512		NA											24	94					0	0	0	0
SLC35B2	347734	broad.mit.edu	37	6	44224086	44224086	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr6:44224086C>T	uc003oxd.2	-	3	489	c.353G>A	c.(352-354)GGG>GAG	p.G118E	SLC35B2_uc011dvt.1_Intron|SLC35B2_uc011dvu.1_Intron	NM_178148	NP_835361	Q8TB61	S35B2_HUMAN	solute carrier family 35, member B2	118	Helical; (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity|signal transducer activity			ovary(1)|central_nervous_system(1)	2	all_cancers(18;2e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			CACCTGGAGCCCTGTGGCACA	0.622		NA											86	199					0	0	0	0
GPR116	221395	broad.mit.edu	37	6	46830642	46830642	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr6:46830642G>C	uc003oyo.3	-	15	2471	c.2182C>G	c.(2182-2184)CTG>GTG	p.L728V	GPR116_uc011dwj.1_Missense_Mutation_p.L283V|GPR116_uc011dwk.1_Missense_Mutation_p.L157V|GPR116_uc003oyp.3_Missense_Mutation_p.L586V|GPR116_uc003oyq.3_Missense_Mutation_p.L728V|GPR116_uc010jzi.1_Missense_Mutation_p.L400V	NM_001098518	NP_001091988	Q8IZF2	GP116_HUMAN	G-protein coupled receptor 116 precursor	728	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|skin(1)	2			Lung(136;0.192)			ATCTGGAGCAGACTGTTTATT	0.502		NA											73	281					0	0	0	0
TNFRSF21	27242	broad.mit.edu	37	6	47200672	47200672	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr6:47200672G>C	uc003oyv.2	-	6	2230	c.1797C>G	c.(1795-1797)ATC>ATG	p.I599M		NM_014452	NP_055267	O75509	TNR21_HUMAN	tumor necrosis factor receptor superfamily,	599	Cytoplasmic (Potential).				cellular lipid metabolic process	cytoplasm|integral to membrane	protein binding|receptor activity				0			Lung(136;0.189)			TGTCATCAAAGATAGGCTGCA	0.498		NA											13	239					0	0	0	0
GCM1	8521	broad.mit.edu	37	6	52993279	52993279	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr6:52993279G>A	uc003pbp.2	-	6	1245	c.1036C>T	c.(1036-1038)CCT>TCT	p.P346S		NM_003643	NP_003634	Q9NP62	GCM1_HUMAN	glial cells missing homolog a	346						transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			central_nervous_system(1)	1	Lung NSC(77;0.0755)					TTGGCTGCAGGTGGCTCCAAT	0.473		NA											39	162					0	0	0	0
BAI3	577	broad.mit.edu	37	6	70071204	70071204	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr6:70071204C>A	uc003pev.3	+	29	4487	c.4039C>A	c.(4039-4041)CCT>ACT	p.P1347T	BAI3_uc010kak.2_Missense_Mutation_p.P1347T|BAI3_uc011dxx.1_Missense_Mutation_p.P553T	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	1347	Cytoplasmic (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				CAAAGTAAACCCTGAATTCAA	0.403		NA											77	122					7.97e-31	1.31e-30	1	0
FAM135A	57579	broad.mit.edu	37	6	71185189	71185189	+	Silent	SNP	T	T	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr6:71185189T>C	uc003pfj.2	+	4	367	c.234T>C	c.(232-234)AAT>AAC	p.N78N	FAM135A_uc003pfi.2_Silent_p.N78N|FAM135A_uc003pfh.2_Silent_p.N35N|FAM135A_uc003pfk.2_Silent_p.N78N|FAM135A_uc003pfl.2_5'UTR	NM_001162529	NP_001156001	Q9P2D6	F135A_HUMAN	hypothetical protein LOC57579 isoform c	78										central_nervous_system(1)	1						TGTACAAAAATGAAGAGGTTG	0.264		NA											5	43					0	0	0	0
ANKRD6	22881	broad.mit.edu	37	6	90331648	90331648	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr6:90331648G>T	uc003pni.3	+	10	1141	c.800G>T	c.(799-801)CGC>CTC	p.R267L	ANKRD6_uc003pne.3_Missense_Mutation_p.R267L|ANKRD6_uc003pnf.3_Intron|ANKRD6_uc011dzy.1_Missense_Mutation_p.R267L|ANKRD6_uc010kcd.2_Missense_Mutation_p.R208L|LYRM2_uc010kce.1_RNA|LYRM2_uc003png.2_RNA|ANKRD6_uc003pnh.3_5'UTR|LYRM2_uc010kcf.1_RNA|ANKRD6_uc003pnj.3_5'UTR	NM_014942	NP_055757	Q9Y2G4	ANKR6_HUMAN	ankyrin repeat domain 6	267	ANK 8.						protein binding			ovary(2)|pancreas(1)	3		all_cancers(76;1.22e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.79e-07)|all_epithelial(107;1.83e-05)|Lung NSC(302;0.239)		BRCA - Breast invasive adenocarcinoma(108;0.0209)		CAGGTCTTGCGCTTCAGTCGT	0.547		NA											22	64					7.45e-12	1.1e-11	1	0
C6orf170	221322	broad.mit.edu	37	6	121482138	121482138	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr6:121482138C>A	uc003pyo.1	-	23	2703	c.2635G>T	c.(2635-2637)GGT>TGT	p.G879C	C6orf170_uc003pyq.1_RNA|C6orf170_uc010kej.1_5'UTR|C6orf170_uc003pyp.1_Missense_Mutation_p.G439C	NM_152730	NP_689943	Q96NH3	BROMI_HUMAN	hypothetical protein LOC221322	879					multicellular organismal development	cilium|cytoplasm	Rab GTPase activator activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(226;0.00521)		AATGGCCCACCAACAAGATTT	0.383		NA											30	82					5.91e-09	8.48e-09	1	0
MAP3K5	4217	broad.mit.edu	37	6	136990454	136990454	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr6:136990454G>A	uc003qhc.2	-	8	1694	c.1333C>T	c.(1333-1335)CAG>TAG	p.Q445*	MAP3K5_uc011edk.1_Nonsense_Mutation_p.Q290*|MAP3K5_uc010kgw.1_Nonsense_Mutation_p.Q445*	NM_005923	NP_005914	Q99683	M3K5_HUMAN	mitogen-activated protein kinase kinase kinase	445					activation of JUN kinase activity|activation of MAPKK activity|cellular response to hydrogen peroxide|induction of apoptosis by extracellular signals|interspecies interaction between organisms		ATP binding|caspase activator activity|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein phosphatase binding			ovary(2)|skin(2)|lung(1)	5	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00137)|OV - Ovarian serous cystadenocarcinoma(155;0.00569)		GATTCAAACTGGTGTCCAGCT	0.393		NA											52	143					0	0	0	0
STXBP5	134957	broad.mit.edu	37	6	147684646	147684646	+	Silent	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr6:147684646G>A	uc003qlz.2	+	24	2882	c.2721G>A	c.(2719-2721)CAG>CAA	p.Q907Q	STXBP5_uc010khz.1_Silent_p.Q871Q|STXBP5_uc003qlx.2_RNA|STXBP5_uc003qly.2_Silent_p.Q562Q	NM_001127715	NP_001121187	Q5T5C0	STXB5_HUMAN	syntaxin binding protein 5 (tomosyn) isoform b	907	WD 12.				exocytosis|positive regulation of exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|nicotinic acetylcholine-gated receptor-channel complex|synaptic vesicle	syntaxin-1 binding				0		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.77e-09)|GBM - Glioblastoma multiforme(68;0.0694)		CCTCTTCTCAGGAAATTAGTG	0.418		NA											16	54					0	0	0	0
MICALL2	79778	broad.mit.edu	37	7	1481953	1481953	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr7:1481953G>T	uc003skj.3	-	7	1733	c.1586C>A	c.(1585-1587)TCC>TAC	p.S529Y	MICALL2_uc003ski.3_Missense_Mutation_p.S16Y	NM_182924	NP_891554	Q8IY33	MILK2_HUMAN	MICAL-like 2 isoform 1	529						cytoplasm|cytoskeleton	zinc ion binding			central_nervous_system(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;6.01e-15)		GGGCAACGCGGATGCCTGAGA	0.667		NA											20	236					7.45e-12	1.1e-11	1	0
FOXK1	221937	broad.mit.edu	37	7	4722314	4722314	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr7:4722314C>G	uc003snc.1	+	1	385	c.375C>G	c.(373-375)ATC>ATG	p.I125M	FOXK1_uc003sna.1_Intron|FOXK1_uc003snb.1_Missense_Mutation_p.I125M	NM_001037165	NP_001032242	P85037	FOXK1_HUMAN	forkhead box K1	125	FHA.				cell differentiation|embryo development|muscle organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|magnesium ion binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			upper_aerodigestive_tract(1)|skin(1)	2		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;7.43e-15)		GCGTCACCATCGGCCGCAACT	0.647		NA											5	38					0	0	0	0
FOXK1	221937	broad.mit.edu	37	7	4800781	4800781	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr7:4800781G>A	uc003snc.1	+	8	1793	c.1783G>A	c.(1783-1785)GGG>AGG	p.G595R	FOXK1_uc003sna.1_Missense_Mutation_p.G432R	NM_001037165	NP_001032242	P85037	FOXK1_HUMAN	forkhead box K1	595					cell differentiation|embryo development|muscle organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|magnesium ion binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			upper_aerodigestive_tract(1)|skin(1)	2		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;7.43e-15)		GATGGCCCCCGGGGTCCCCGG	0.672		NA											42	93					0	0	0	0
TNRC18	84629	broad.mit.edu	37	7	5353145	5353145	+	Silent	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr7:5353145C>T	uc003soi.3	-	27	7726	c.7377G>A	c.(7375-7377)GAG>GAA	p.E2459E		NM_001080495	NP_001073964	O15417	TNC18_HUMAN	trinucleotide repeat containing 18	2459							DNA binding				0		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		TGACAAGCAGCTCGGCCTCCT	0.687		NA											21	38					0	0	0	0
DNAH11	8701	broad.mit.edu	37	7	21640667	21640667	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr7:21640667T>C	uc003svc.2	+	17	3326	c.3295T>C	c.(3295-3297)TTT>CTT	p.F1099L		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1099	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						AATGAGCAAATTTGAGGACTT	0.333		NA							Kartagener_syndrome				22	74					0	0	0	0
C7orf30	115416	broad.mit.edu	37	7	23348989	23348989	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr7:23348989C>T	uc003swd.1	+	4	564	c.532C>T	c.(532-534)CAT>TAT	p.H178Y	C7orf30_uc003swe.2_RNA	NM_138446	NP_612455	Q96EH3	CG030_HUMAN	hypothetical protein LOC115416	178						mitochondrion					0			GBM - Glioblastoma multiforme(13;0.154)			CATGGTGATTCATTTGATGCT	0.398		NA											39	127					0	0	0	0
HERPUD2	64224	broad.mit.edu	37	7	35673933	35673933	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr7:35673933G>C	uc003tet.2	-	7	1853	c.1048C>G	c.(1048-1050)CTT>GTT	p.L350V	HERPUD2_uc003tes.3_Missense_Mutation_p.L350V	NM_022373	NP_071768	Q9BSE4	HERP2_HUMAN	HERPUD family member 2	350					response to unfolded protein	integral to membrane				ovary(3)	3						ATTTCTTCAAGTTCCAAGTTG	0.408		NA											35	66					0	0	0	0
DBNL	28988	broad.mit.edu	37	7	44091508	44091508	+	Silent	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr7:44091508C>T	uc003tjp.3	+	3	317	c.219C>T	c.(217-219)AAC>AAT	p.N73N	DBNL_uc003tjn.2_Intron|DBNL_uc003tjo.3_Silent_p.N73N|DBNL_uc003tjr.3_Intron|DBNL_uc003tjq.3_Silent_p.N73N|DBNL_uc011kbm.1_Silent_p.N73N|DBNL_uc011kbn.1_Intron|DBNL_uc011kbo.1_Intron|DBNL_uc011kbp.1_Silent_p.N73N|DBNL_uc011kbq.1_Intron|DBNL_uc011kbr.1_Silent_p.N21N|DBNL_uc011kbs.1_5'Flank	NM_001014436	NP_001014436	Q9UJU6	DBNL_HUMAN	drebrin-like isoform b	73	ADF-H.				activation of JUN kinase activity|cellular component disassembly involved in apoptosis|endocytosis|Rac protein signal transduction	cell cortex|cytoskeleton|cytosol|lamellipodium	actin binding|enzyme activator activity|identical protein binding			skin(1)	1						AGGACCCCAACTCTGGACTGC	0.527		NA											33	97					0	0	0	0
SUMF2	25870	broad.mit.edu	37	7	56147375	56147375	+	Silent	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr7:56147375C>T	uc003trv.2	+	8	919	c.888C>T	c.(886-888)AGC>AGT	p.S296S	PSPH_uc003trj.2_Intron|SUMF2_uc011kcv.1_RNA|SUMF2_uc011kcw.1_3'UTR|SUMF2_uc011kcx.1_3'UTR|SUMF2_uc003trt.2_3'UTR|SUMF2_uc011kcy.1_3'UTR|SUMF2_uc011kcz.1_3'UTR|SUMF2_uc003tru.2_RNA|SUMF2_uc011kda.1_Silent_p.S109S|SUMF2_uc003trx.2_RNA	NM_001130069	NP_001123541	Q8NBJ7	SUMF2_HUMAN	sulfatase modifying factor 2 isoform e	Error:Variant_position_missing_in_Q8NBJ7_after_alignment						endoplasmic reticulum lumen	metal ion binding			ovary(1)|skin(1)	2	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			TTGCAAACAGCGCAATTCCAA	0.602		NA									OREG0018082	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	52					0	0	0	0
RABGEF1	27342	broad.mit.edu	37	7	66236935	66236935	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr7:66236935C>G	uc011kee.1	+	2	255	c.91C>G	c.(91-93)CTC>GTC	p.L31V	RABGEF1_uc003tvf.2_Translation_Start_Site|RABGEF1_uc003tvg.2_Translation_Start_Site|RABGEF1_uc010lag.2_Missense_Mutation_p.L17V|RABGEF1_uc003tvh.2_Missense_Mutation_p.L17V|RABGEF1_uc003tvi.2_Translation_Start_Site	NM_014504	NP_055319	Q9UJ41	RABX5_HUMAN	RAB guanine nucleotide exchange factor (GEF) 1	155	Interaction with ubiquitinated proteins.|A20-type.				endocytosis|protein transport	early endosome|recycling endosome	DNA binding|protein binding|zinc ion binding			ovary(1)	1						TCAATCGGATCTCCTGTGCAA	0.483		NA											50	231					0	0	0	0
TYW1	55253	broad.mit.edu	37	7	66479523	66479523	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr7:66479523C>T	uc003tvn.2	+	5	694	c.545C>T	c.(544-546)TCT>TTT	p.S182F	TYW1_uc010lai.2_RNA	NM_018264	NP_060734	Q9NV66	TYW1_HUMAN	radical S-adenosyl methionine and flavodoxin	182	FMN (By similarity).|Flavodoxin-like.				tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity			skin(1)	1		Lung NSC(55;0.0846)|all_lung(88;0.183)				CTGGGAAATTCTGCCTATGCT	0.333		NA											63	293					0	0	0	0
ABCB4	5244	broad.mit.edu	37	7	87056098	87056098	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr7:87056098G>A	uc003uiv.1	-	16	2108	c.2032C>T	c.(2032-2034)CAG>TAG	p.Q678*	ABCB4_uc003uiw.1_Nonsense_Mutation_p.Q678*|ABCB4_uc003uix.1_Nonsense_Mutation_p.Q678*	NM_018849	NP_061337	P21439	MDR3_HUMAN	ATP-binding cassette, subfamily B, member 4	678	Cytoplasmic (By similarity).				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			ovary(4)|skin(1)|pancreas(1)	6	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					AGGCTCTTCTGACACATTTGT	0.353		NA											27	39					0	0	0	0
COL1A2	1278	broad.mit.edu	37	7	94057155	94057155	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr7:94057155A>C	uc003ung.1	+	49	3955	c.3484A>C	c.(3484-3486)ACA>CCA	p.T1162P	COL1A2_uc011kib.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	1162	Fibrillar collagen NC1.				axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	CCCAGCTCGCACATGCCGTGA	0.488		NA								HNSCC(75;0.22)			32	24					0	0	0	0
TRIP6	7205	broad.mit.edu	37	7	100466214	100466214	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr7:100466214C>T	uc003uww.2	+	4	631	c.461C>T	c.(460-462)CCA>CTA	p.P154L	TRIP6_uc010lhk.1_RNA	NM_003302	NP_003293	Q15654	TRIP6_HUMAN	thyroid receptor-interacting protein 6	154					focal adhesion assembly|positive regulation of cell migration|regulation of transcription, DNA-dependent|release of cytoplasmic sequestered NF-kappaB|transcription, DNA-dependent	cytoplasm|cytoskeleton|focal adhesion|nucleus	identical protein binding|interleukin-1 receptor binding|kinase binding|thyroid hormone receptor binding|zinc ion binding			central_nervous_system(2)	2	Lung NSC(181;0.041)|all_lung(186;0.0581)					GGCCCCACTCCAGCCTCTTAC	0.697		NA											7	65					0	0	0	0
MUC17	140453	broad.mit.edu	37	7	100677694	100677694	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr7:100677694G>T	uc003uxp.1	+	3	3050	c.2997G>T	c.(2995-2997)GAG>GAT	p.E999D	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	999	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|14.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CCAATTCTGAGGCTAGCACCC	0.522		NA											307	339					9.83e-173	1.68e-172	1	0
CUX1	1523	broad.mit.edu	37	7	101918582	101918582	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr7:101918582C>G	uc003uyt.2	+	17	1534	c.1515C>G	c.(1513-1515)ATC>ATG	p.I505M	CUX1_uc011kkn.1_Missense_Mutation_p.I466M|CUX1_uc003uyw.2_Missense_Mutation_p.I459M|CUX1_uc003uyv.2_Missense_Mutation_p.I489M|CUX1_uc003uyu.2_Missense_Mutation_p.I503M|CUX1_uc003uyz.2_RNA	NM_001913	NP_001904	P39880	CUX1_HUMAN	cut-like homeobox 1 isoform b	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8						TTTCCATCATCTCCAGCCAGA	0.632		NA											12	92					0	0	0	0
CPA4	51200	broad.mit.edu	37	7	129948163	129948163	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr7:129948163A>C	uc003vpr.2	+	8	766	c.719A>C	c.(718-720)AAG>ACG	p.K240T	CPA4_uc011kpd.1_Missense_Mutation_p.K207T|CPA4_uc011kpe.1_Missense_Mutation_p.K136T	NM_016352	NP_057436	Q9UI42	CBPA4_HUMAN	carboxypeptidase A4 preproprotein	240					histone acetylation|proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			ovary(1)	1	Melanoma(18;0.0435)					TTATGGAGGAAGACGCGGTCC	0.537		NA											31	40					0	0	0	0
OR2A25	392138	broad.mit.edu	37	7	143772094	143772094	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr7:143772094C>A	uc011ktx.1	+	1	782	c.782C>A	c.(781-783)CCC>CAC	p.P261H		NM_001004488	NP_001004488	A4D2G3	O2A25_HUMAN	olfactory receptor, family 2, subfamily A,	261	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Melanoma(164;0.0783)					TATGTTGAGCCCCAGTATGAG	0.488		NA											135	168					2.45e-52	4.16e-52	1	0
C7orf33	202865	broad.mit.edu	37	7	148311217	148311217	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr7:148311217G>T	uc003wew.2	+	2	649	c.288G>T	c.(286-288)TGG>TGT	p.W96C		NM_145304	NP_660347	Q8WU49	CG033_HUMAN	hypothetical protein LOC202865	96										central_nervous_system(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			GTGCCCCGTGGCATTTTCTTT	0.517		NA											27	57					8.25e-16	1.26e-15	1	0
GIMAP6	474344	broad.mit.edu	37	7	150325508	150325508	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr7:150325508T>C	uc003whn.2	-	3	602	c.178A>G	c.(178-180)ATC>GTC	p.I60V	GIMAP6_uc003whm.2_Intron	NM_024711	NP_078987	Q6P9H5	GIMA6_HUMAN	GTPase, IMAP family member 6	60							GTP binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CTGCCGAGGATGCTGTTTCCT	0.547		NA											20	477					0	0	0	0
ABP1	26	broad.mit.edu	37	7	150557669	150557669	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr7:150557669C>A	uc003why.1	+	5	6155	c.1937C>A	c.(1936-1938)CCG>CAG	p.P646Q	ABP1_uc003whz.1_Missense_Mutation_p.P646Q|ABP1_uc003wia.1_Missense_Mutation_p.P665Q	NM_001091	NP_001082	P19801	ABP1_HUMAN	amiloride binding protein 1 precursor	646					amine metabolic process	extracellular space|peroxisome	copper ion binding|diamine oxidase activity|heparin binding|histamine oxidase activity|methylputrescine oxidase activity|primary amine oxidase activity|propane-1,3-diamine oxidase activity|quinone binding			ovary(2)|breast(2)|skin(2)	6	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiloride(DB00594)|Spermine(DB00127)	CCCTGGCACCCGCCCGTGGTC	0.617		NA											81	73					1.35e-34	2.25e-34	1	0
UNC5D	137970	broad.mit.edu	37	8	35608237	35608237	+	Silent	SNP	G	G	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr8:35608237G>T	uc003xjr.1	+	13	2401	c.2073G>T	c.(2071-2073)CTG>CTT	p.L691L	UNC5D_uc003xjs.1_Silent_p.L686L|UNC5D_uc003xju.1_Silent_p.L267L	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	691	Cytoplasmic (Potential).				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		TGAAGCAACTGAAGGTGGCGG	0.507		NA											31	306					5.46e-16	8.33e-16	1	0
UNC5D	137970	broad.mit.edu	37	8	35624547	35624547	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr8:35624547A>G	uc003xjr.1	+	15	2769	c.2441A>G	c.(2440-2442)CAT>CGT	p.H814R	UNC5D_uc003xjs.1_Missense_Mutation_p.H809R|UNC5D_uc003xju.1_Missense_Mutation_p.H390R	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	814	Cytoplasmic (Potential).				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		CTCAAAGGCCATGAACAGATC	0.507		NA											93	121					0	0	0	0
MYST3	7994	broad.mit.edu	37	8	41792081	41792081	+	Silent	SNP	T	T	C	rs7820342		TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr8:41792081T>C	uc010lxb.2	-	18	4201	c.3657A>G	c.(3655-3657)CTA>CTG	p.L1219L	MYST3_uc010lxc.2_Silent_p.L1219L|MYST3_uc003xon.3_Silent_p.L1219L	NM_001099412	NP_001092882	Q92794	MYST3_HUMAN	MYST histone acetyltransferase (monocytic	1219					histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7	all_epithelial(6;1.12e-27)|all_lung(13;3.94e-12)|Lung NSC(13;6.54e-11)|Ovarian(28;0.00744)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000294)|Lung NSC(58;0.00105)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	Epithelial(1;2.82e-19)|all cancers(1;1.15e-16)|BRCA - Breast invasive adenocarcinoma(8;9.17e-11)|OV - Ovarian serous cystadenocarcinoma(14;9.4e-05)|Colorectal(10;0.000728)|Lung(22;0.00153)|LUSC - Lung squamous cell carcinoma(45;0.00741)|COAD - Colon adenocarcinoma(11;0.0171)			tctcctcGGGTAGGGGCATGT	0.343		NA											58	67					0	0	0	0
YTHDF3	253943	broad.mit.edu	37	8	64099575	64099575	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr8:64099575C>T	uc003xuy.2	+	5	1322	c.1006C>T	c.(1006-1008)CCA>TCA	p.P336S	YTHDF3_uc010lys.2_Missense_Mutation_p.P280S|YTHDF3_uc003xuz.2_Missense_Mutation_p.P280S|YTHDF3_uc003xva.2_Missense_Mutation_p.P280S|YTHDF3_uc011len.1_Missense_Mutation_p.P280S	NM_152758	NP_689971	Q7Z739	YTHD3_HUMAN	YTH domain family, member 3	336											0	Breast(64;0.0716)	all_cancers(86;0.169)|Lung NSC(129;0.0324)|all_lung(136;0.0593)|all_epithelial(80;0.146)	BRCA - Breast invasive adenocarcinoma(89;0.161)			AGGACCTCAGCCACAGGCCCA	0.567		NA											14	31					0	0	0	0
PREX2	80243	broad.mit.edu	37	8	69005862	69005862	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr8:69005862A>T	uc003xxv.1	+	21	2300	c.2273A>T	c.(2272-2274)TAT>TTT	p.Y758F	PREX2_uc003xxu.1_Missense_Mutation_p.Y758F|PREX2_uc011lez.1_Missense_Mutation_p.Y693F	NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	758					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						CAATGGGTTTATAATAGCATT	0.438		NA											49	101					0	0	0	0
KIAA1429	25962	broad.mit.edu	37	8	95547138	95547138	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr8:95547138G>A	uc003ygo.1	-	5	426	c.413C>T	c.(412-414)TCT>TTT	p.S138F	KIAA1429_uc003ygp.2_Missense_Mutation_p.S138F	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	138					mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			tggtggtggAGAGTCTCTGTC	0.353		NA											41	109					0	0	0	0
UBR5	51366	broad.mit.edu	37	8	103335611	103335611	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr8:103335611C>A	uc003ykr.1	-	14	1745	c.1712G>T	c.(1711-1713)AGC>ATC	p.S571I	UBR5_uc003yks.1_Missense_Mutation_p.S571I	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	571					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			AAATCTACAGCTGTCATTCAT	0.363		NA											15	44					0.00244969	0.00324258	1	0
KCNV1	27012	broad.mit.edu	37	8	110980568	110980568	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr8:110980568G>A	uc003ynr.3	-	3	1594	c.1252C>T	c.(1252-1254)CTT>TTT	p.L418F	KCNV1_uc010mcw.2_Missense_Mutation_p.L418F	NM_014379	NP_055194	Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	418	Helical; Name=Segment S6; (Potential).					voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			lung(1)|kidney(1)	2	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			GCCAAGACAAGAATTCCCGAT	0.478		NA											51	113					0	0	0	0
CSMD3	114788	broad.mit.edu	37	8	113668540	113668540	+	Silent	SNP	C	C	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr8:113668540C>G	uc003ynu.2	-	18	3006	c.2847G>C	c.(2845-2847)CTG>CTC	p.L949L	CSMD3_uc003yns.2_Silent_p.L221L|CSMD3_uc003ynt.2_Silent_p.L909L|CSMD3_uc011lhx.1_Silent_p.L845L	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	949	Extracellular (Potential).|CUB 5.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CATGAACTTCCAGAACATCAT	0.343		NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			28	69					0	0	0	0
WISP1	8840	broad.mit.edu	37	8	134232922	134232922	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr8:134232922G>T	uc003yub.2	+	3	524	c.448G>T	c.(448-450)GCG>TCG	p.A150S	WISP1_uc003yuc.2_Intron|WISP1_uc010meb.2_Intron|WISP1_uc010mec.2_Intron|WISP1_uc010med.2_Intron|WISP1_uc003yud.2_Intron	NM_003882	NP_003873	O95388	WISP1_HUMAN	WNT1 inducible signaling pathway protein 1	150	VWFC.				cell adhesion|cell-cell signaling|regulation of cell growth|Wnt receptor signaling pathway	extracellular region|soluble fraction	insulin-like growth factor binding			central_nervous_system(1)|kidney(1)	2	all_epithelial(106;5.39e-23)|Lung NSC(106;7.26e-07)|all_lung(105;2.77e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0107)			CATCGACGGCGCGGTGGGCTG	0.667		NA											50	138					1.4e-22	2.24e-22	1	0
GLI4	2738	broad.mit.edu	37	8	144358699	144358699	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr8:144358699C>T	uc003yxx.2	+	4	941	c.856C>T	c.(856-858)CAG>TAG	p.Q286*	ZFP41_uc003yxv.2_RNA	NM_138465	NP_612474	P10075	GLI4_HUMAN	GLI-Kruppel family member GLI4	286	C2H2-type 4.					nucleus	DNA binding|zinc ion binding				0	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)			GGTGCGCCACCAGCGGCTGCA	0.657		NA											21	35					0	0	0	0
RHPN1	114822	broad.mit.edu	37	8	144463846	144463846	+	Silent	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr8:144463846G>A	uc003yyb.2	+	13	1726	c.1593G>A	c.(1591-1593)TCG>TCA	p.S531S		NM_052924	NP_443156	Q8TCX5	RHPN1_HUMAN	rhophilin 1	556	PDZ.				signal transduction	intracellular				large_intestine(1)	1	all_cancers(97;7.39e-11)|all_epithelial(106;5.44e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.156)			GGGGAGACTCGCCTGTCCTCA	0.692		NA											23	39					0	0	0	0
KANK1	23189	broad.mit.edu	37	9	712501	712501	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr9:712501G>C	uc003zgl.1	+	7	2384	c.1735G>C	c.(1735-1737)GAC>CAC	p.D579H	KANK1_uc003zgm.2_Missense_Mutation_p.D579H|KANK1_uc003zgn.1_Missense_Mutation_p.D579H|KANK1_uc003zgo.1_Missense_Mutation_p.D579H|KANK1_uc003zgp.1_Missense_Mutation_p.D579H|KANK1_uc003zgq.2_Missense_Mutation_p.D421H|KANK1_uc003zgr.1_Missense_Mutation_p.D421H|KANK1_uc003zgs.1_Missense_Mutation_p.D421H	NM_015158	NP_055973	Q14678	KANK1_HUMAN	KN motif and ankyrin repeat domains 1 isoform a	579					negative regulation of actin filament polymerization	cytoplasm				ovary(2)|central_nervous_system(1)|pancreas(1)	4		Lung NSC(10;9.84e-12)|all_lung(10;1.02e-11)|Breast(48;0.128)		Epithelial(6;0.000153)|OV - Ovarian serous cystadenocarcinoma(1;0.000358)|Lung(218;0.0222)		GGAAATGCATGACCGATGTGC	0.507		NA											30	196					0	0	0	0
DNAI1	27019	broad.mit.edu	37	9	34493300	34493300	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr9:34493300A>G	uc003zum.2	+	9	983	c.790A>G	c.(790-792)AGG>GGG	p.R264G		NM_012144	NP_036276	Q9UI46	DNAI1_HUMAN	dynein, axonemal, intermediate chain 1	264					cell projection organization	cilium axoneme|cytoplasm|dynein complex|microtubule	motor activity				0	all_epithelial(49;0.244)		LUSC - Lung squamous cell carcinoma(29;0.0107)|STAD - Stomach adenocarcinoma(86;0.212)	GBM - Glioblastoma multiforme(74;0.0222)		GATGGCCATGAGGAAGCTGAC	0.478		NA							Kartagener_syndrome				39	53					0	0	0	0
TLN1	7094	broad.mit.edu	37	9	35706887	35706887	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr9:35706887G>C	uc003zxt.2	-	38	5320	c.4966C>G	c.(4966-4968)CCA>GCA	p.P1656A		NM_006289	NP_006280	Q9Y490	TLN1_HUMAN	talin 1	1656	Interaction with SYNM.				axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			lung(7)|breast(3)|ovary(2)|central_nervous_system(1)	13	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			AGCTGCCCTGGAGCCTTGTCC	0.582		NA											4	116					0	0	0	0
FLJ46321	389763	broad.mit.edu	37	9	84609741	84609741	+	Silent	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr9:84609741G>A	uc004amn.2	+	4	4403	c.4356G>A	c.(4354-4356)GAG>GAA	p.E1452E		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	1452						integral to membrane					0						TCAGAGCAGAGCCTGTCCAGG	0.532		NA											33	37					0	0	0	0
OR13C4	138804	broad.mit.edu	37	9	107288743	107288743	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr9:107288743T>C	uc011lvn.1	-	1	748	c.748A>G	c.(748-750)ATA>GTA	p.I250V		NM_001001919	NP_001001919	Q8NGS5	O13C4_HUMAN	olfactory receptor, family 13, subfamily C,	250	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						CCATAAAATATGATCACCACA	0.453		NA											80	63					0	0	0	0
ABCA1	19	broad.mit.edu	37	9	107586827	107586827	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr9:107586827G>A	uc004bcl.2	-	18	2888	c.2575C>T	c.(2575-2577)CCT>TCT	p.P859S		NM_005502	NP_005493	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A member 1	859					Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			large_intestine(4)|lung(4)|ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	17				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	TTGGTGCAAGGAAAATACCAG	0.507		NA											56	38					0	0	0	0
TTC16	158248	broad.mit.edu	37	9	130485521	130485521	+	Silent	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr9:130485521C>T	uc004brq.1	+	7	848	c.781C>T	c.(781-783)CTG>TTG	p.L261L	PTRH1_uc011mah.1_Intron|TTC16_uc011mai.1_Silent_p.L248L|TTC16_uc004brr.1_Silent_p.L206L|TTC16_uc010mxn.1_5'UTR	NM_144965	NP_659402	Q8NEE8	TTC16_HUMAN	tetratricopeptide repeat domain 16	261	TPR 4.						binding				0						TGCGGGGATCCTGGCTGTGCA	0.632		NA											41	22					0	0	0	0
NUP188	23511	broad.mit.edu	37	9	131768858	131768858	+	Silent	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr9:131768858G>A	uc004bws.1	+	44	5173	c.5151G>A	c.(5149-5151)TCG>TCA	p.S1717S		NM_015354	NP_056169	Q5SRE5	NU188_HUMAN	nucleoporin 188kDa	1717					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|kidney(1)|breast(1)	7						TCCTCCCCTCGCCGCAGGGCA	0.612		NA									OREG0019528	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	79	53					0	0	0	0
DBH	1621	broad.mit.edu	37	9	136522303	136522303	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr9:136522303C>A	uc004cel.2	+	11	1683	c.1674C>A	c.(1672-1674)TTC>TTA	p.F558L	uc010nao.1_Silent_p.A26A	NM_000787	NP_000778	P09172	DOPO_HUMAN	dopamine beta hydroxylase precursor	558	Intragranular (Potential).				hormone biosynthetic process	chromaffin granule lumen|chromaffin granule membrane|extracellular region|integral to membrane|membrane fraction|soluble fraction|transport vesicle membrane	dopamine beta-monooxygenase activity|L-ascorbic acid binding			ovary(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(145;2.33e-07)|Epithelial(140;1.5e-06)|all cancers(34;1.66e-05)	Dopamine(DB00988)|Vitamin C(DB00126)	TGTACAGCTTCGCGCCCATCT	0.632		NA											38	57					2.87e-16	4.39e-16	1	0
TLR7	51284	broad.mit.edu	37	X	12904444	12904444	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chrX:12904444T>G	uc004cvc.2	+	3	956	c.817T>G	c.(817-819)TGT>GGT	p.C273G		NM_016562	NP_057646	Q9NYK1	TLR7_HUMAN	toll-like receptor 7 precursor	273	Extracellular (Potential).|LRR 9.				cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity			ovary(2)|lung(2)|breast(1)	5					Imiquimod(DB00724)	TTGTGCGCCGTGTAAAAATAA	0.388		NA											56	70					0	0	0	0
YY2	404281	broad.mit.edu	37	X	21863309	21863309	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chrX:21863309T>G	uc010nfq.2	+	3	442	c.245T>G	c.(244-246)TTT>TGT	p.F82C	MBTPS2_uc004dae.2_Missense_Mutation_p.F82C|MBTPS2_uc004dab.2_Missense_Mutation_p.F82C	NM_206923	NP_996806	O15391	TYY2_HUMAN	YY2 transcription factor	Error:Variant_position_missing_in_O15391_after_alignment					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|plasma membrane	DNA binding|zinc ion binding			breast(1)|skin(1)	2						GGAATGGTGTTTGGCGTAATT	0.333		NA											59	60					0	0	0	0
CXorf59	286464	broad.mit.edu	37	X	36162677	36162677	+	Splice_Site	SNP	G	G	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chrX:36162677G>C	uc004ddk.1	+	11	1447	c.1261_splice	c.e11-1	p.V421_splice		NM_173695	NP_775966	Q8N9S7	CX059_HUMAN	hypothetical protein LOC286464							integral to membrane				central_nervous_system(1)	1						tttgtttctaggtgtgtctga	0.01		NA											47	74					0	0	0	0
USP9X	8239	broad.mit.edu	37	X	41069829	41069829	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chrX:41069829G>T	uc004dfb.2	+	33	5716	c.5083G>T	c.(5083-5085)GAT>TAT	p.D1695Y	USP9X_uc004dfc.2_Missense_Mutation_p.D1695Y	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform	1695					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6						TTCATTGGTGGATAGTTTAGA	0.388		NA											43	36					1.23e-20	1.94e-20	1	0
HUWE1	10075	broad.mit.edu	37	X	53634558	53634558	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chrX:53634558G>A	uc004dsp.2	-	25	2824	c.2422C>T	c.(2422-2424)CTT>TTT	p.L808F		NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	808					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						AGATTGGGAAGACCCAAAATG	0.438		NA											10	92					0	0	0	0
TSR2	90121	broad.mit.edu	37	X	54469925	54469925	+	Splice_Site	SNP	G	G	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chrX:54469925G>T	uc004dte.2	+	3	266	c.264_splice	c.e3+1	p.Q88_splice	TSR2_uc004dtf.2_Splice_Site	NM_058163	NP_477511	Q969E8	TSR2_HUMAN	TSR2, 20S rRNA accumulation, homolog						rRNA processing		protein binding				0						TCTGCCCCAGGTGAGCTTATC	0.512		NA											51	125					7.05e-20	1.11e-19	1	0
FAAH2	158584	broad.mit.edu	37	X	57313310	57313310	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chrX:57313310G>A	uc004dvc.2	+	1	201	c.52G>A	c.(52-54)GGC>AGC	p.G18S		NM_174912	NP_777572	Q6GMR7	FAAH2_HUMAN	fatty acid amide hydrolase 2	18	Helical; (Potential).					integral to membrane	carbon-nitrogen ligase activity, with glutamine as amido-N-donor|hydrolase activity			ovary(3)	3						GCGGGCGCTAGGCTTTCTCAT	0.562		NA								HNSCC(52;0.14)			8	31					0	0	0	0
KIAA2022	340533	broad.mit.edu	37	X	73960704	73960704	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chrX:73960704C>T	uc004eby.2	-	3	4305	c.3688G>A	c.(3688-3690)GCT>ACT	p.A1230T		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	1230					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						TTGATGGCAGCCATGTATTTC	0.473		NA											33	85					0	0	0	0
ATRX	546	broad.mit.edu	37	X	76874427	76874427	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chrX:76874427G>C	uc004ecp.3	-	21	5527	c.5295C>G	c.(5293-5295)ATC>ATG	p.I1765M	ATRX_uc004ecq.3_Missense_Mutation_p.I1727M|ATRX_uc004eco.3_Missense_Mutation_p.I1550M	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	1765	Helicase ATP-binding.				DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	AATTTTCCTTGATAAAATTAA	0.313		NA	Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						8	41					0	0	0	0
PABPC5	140886	broad.mit.edu	37	X	90690736	90690736	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chrX:90690736G>T	uc004efg.2	+	2	600	c.160G>T	c.(160-162)GTG>TTG	p.V54L	PABPC5_uc004eff.1_Intron	NM_080832	NP_543022	Q96DU9	PABP5_HUMAN	poly(A) binding protein, cytoplasmic 5	54	RRM 1.					cytoplasm	nucleotide binding|RNA binding			ovary(1)|lung(1)|pancreas(1)	3						CCGTGATCCGGTGACCCGCAG	0.537		NA											14	17					1.36e-13	2.05e-13	1	0
TNMD	64102	broad.mit.edu	37	X	99854535	99854535	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chrX:99854535C>A	uc004efy.3	+	7	1001	c.775C>A	c.(775-777)CTG>ATG	p.L259M	TNMD_uc004efz.2_3'UTR	NM_022144	NP_071427	Q9H2S6	TNMD_HUMAN	tenomodulin	259	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1						TGATCCCATGCTGGATGAGAG	0.478		NA											17	10					3.41e-10	4.99e-10	1	0
ZMAT1	84460	broad.mit.edu	37	X	101139207	101139207	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chrX:101139207C>G	uc004eim.2	-	2	4177	c.679G>C	c.(679-681)GAT>CAT	p.D227H	ZMAT1_uc011mrl.1_Missense_Mutation_p.D398H|ZMAT1_uc004ein.2_Missense_Mutation_p.D227H|ZMAT1_uc011mrm.1_Missense_Mutation_p.D227H	NM_032441	NP_115817	Q5H9K5	ZMAT1_HUMAN	zinc finger, matrin type 1 isoform 3	227						nucleus	zinc ion binding			ovary(1)	1						TTTATGTAATCTTCAAGTTCA	0.413		NA											14	310					0	0	0	0
GRIA3	2892	broad.mit.edu	37	X	122318400	122318400	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chrX:122318400A>G	uc004etq.3	+	2	306	c.13A>G	c.(13-15)AAG>GAG	p.K5E	GRIA3_uc004etr.3_Missense_Mutation_p.K5E|GRIA3_uc004ets.3_RNA|GRIA3_uc011muf.1_5'Flank|GRIA3_uc010nqs.1_Missense_Mutation_p.K5E	NM_007325	NP_015564	P42263	GRIA3_HUMAN	glutamate receptor, ionotrophic, AMPA 3 isoform	5					glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5					L-Glutamic Acid(DB00142)	GGCCAGGCAGAAGAAAATGGG	0.483		NA											94	97					0	0	0	0
SLITRK2	84631	broad.mit.edu	37	X	144906314	144906314	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chrX:144906314C>T	uc004fcd.2	+	5	3361	c.2371C>T	c.(2371-2373)CGA>TGA	p.R791*	SLITRK2_uc010nsp.2_Nonsense_Mutation_p.R791*|SLITRK2_uc010nso.2_Nonsense_Mutation_p.R791*|SLITRK2_uc011mwq.1_Nonsense_Mutation_p.R791*|SLITRK2_uc011mwr.1_Nonsense_Mutation_p.R791*|SLITRK2_uc011mws.1_Nonsense_Mutation_p.R791*|SLITRK2_uc004fcg.2_Nonsense_Mutation_p.R791*|SLITRK2_uc011mwt.1_Nonsense_Mutation_p.R791*|CXorf1_uc004fch.2_5'Flank	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2 precursor	791	Cytoplasmic (Potential).					integral to membrane				ovary(5)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					CTATGAATCTCGACGCCAAAA	0.453		NA											98	109					0	0	0	0
FLNA	2316	broad.mit.edu	37	X	153594777	153594777	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chrX:153594777T>A	uc004fkk.2	-	8	1376	c.1127A>T	c.(1126-1128)AAG>ATG	p.K376M	FLNA_uc010nuu.1_Missense_Mutation_p.K376M	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	376	Filamin 2.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					ACCCTGTGACTTATCCACGTA	0.597		NA											13	73					0	0	0	0
JTB	10899	broad.mit.edu	37	1	153949693	153949710	+	In_Frame_Del	DEL	CTGGGGGAGGCCAGGCCT	CTGGGGGAGGCCAGGCCT	-			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:153949693_153949710delCTGGGGGAGGCCAGGCCT	uc001fds.2	-	1	742_759	c.19_36delAGGCCTGGCCTCCCCCAG	c.(19-36)AGGCCTGGCCTCCCCCAGdel	p.RPGLPQ7del		NM_006694	NP_006685	O76095	JTB_HUMAN	jumping translocation breakpoint precursor	7_12					apoptosis|cell cycle cytokinesis|mitosis|positive regulation of protein kinase activity	integral to plasma membrane|membrane fraction|microtubule organizing center|midbody|mitochondrion|spindle	protein kinase binding				0	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GGTGGCGGCCCTGGGGGAGGCCAGGCCTCCCGGCACCC	0.638		NA											18	153	---	---	---	---	NA	NA	NA	NA
COPA	1314	broad.mit.edu	37	1	160264643	160264662	+	Splice_Site	DEL	CTTCCCTACAGAGGGAAGGA	CTTCCCTACAGAGGGAAGGA	-			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:160264643_160264662delCTTCCCTACAGAGGGAAGGA	uc009wti.2	-	24	2871	c.2477_splice	c.e24-1	p.G826_splice	COPA_uc001fvv.3_Splice_Site_p.G835_splice	NM_004371	NP_004362	P53621	COPA_HUMAN	coatomer protein complex, subunit alpha isoform						COPI coating of Golgi vesicle|intracellular protein transport|pancreatic juice secretion|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|extracellular space|microsome|soluble fraction	hormone activity|structural molecule activity			ovary(1)|skin(1)	2	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GTGCTCCTCCCTTCCCTACAGAGGGAAGGAACAGAACGGA	0.491		NA											16	100	---	---	---	---	NA	NA	NA	NA
USH2A	7399	broad.mit.edu	37	1	216052268	216052268	+	Frame_Shift_Del	DEL	C	C	-	rs148433761		TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr1:216052268delC	uc001hku.1	-	42	8783	c.8396delG	c.(8395-8397)GGTfs	p.G2799fs		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	2799	Fibronectin type-III 14.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GTACCCATTACCCCCTGAGCA	0.443		NA								HNSCC(13;0.011)			76	154	---	---	---	---	NA	NA	NA	NA
SPTY2D1	144108	broad.mit.edu	37	11	18636297	18636298	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:18636297_18636298insT	uc001moy.2	-	3	1739_1740	c.1523_1524insA	c.(1522-1524)AATfs	p.N508fs	SPTY2D1_uc010rdi.1_Frame_Shift_Ins_p.N508fs	NM_194285	NP_919261	Q68D10	SPT2_HUMAN	SPT2, Suppressor of Ty, domain containing 1	508	Ser-rich.									breast(1)	1						CTGGGACTGAATTACTGACAGT	0.559		NA											33	76	---	---	---	---	NA	NA	NA	NA
CPSF7	79869	broad.mit.edu	37	11	61179315	61179320	+	In_Frame_Del	DEL	GATGAG	GATGAG	-			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:61179315_61179320delGATGAG	uc001nrq.2	-	8	1308_1313	c.1174_1179delCTCATC	c.(1174-1179)CTCATCdel	p.LI392del	CPSF7_uc001nro.2_In_Frame_Del_p.LI383del|CPSF7_uc001nrp.2_In_Frame_Del_p.LI435del|CPSF7_uc001nrr.2_In_Frame_Del_p.LI383del	NM_001136040	NP_001129512	Q8N684	CPSF7_HUMAN	pre-mRNA cleavage factor I, 59 kDa subunit	392_393					mRNA 3'-end processing|nuclear mRNA splicing, via spliceosome|protein tetramerization|termination of RNA polymerase II transcription	mRNA cleavage factor complex	nucleotide binding|protein binding|RNA binding			central_nervous_system(1)	1						TAAGAGAGGAGATGAGGACACGGCAA	0.524		NA											29	82	---	---	---	---	NA	NA	NA	NA
ME3	10873	broad.mit.edu	37	11	86152375	86152378	+	Frame_Shift_Del	DEL	AAAG	AAAG	-			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr11:86152375_86152378delAAAG	uc001pbz.2	-	14	2012_2015	c.1758_1761delCTTT	c.(1756-1761)TCCTTTfs	p.S586fs	ME3_uc001pca.2_Frame_Shift_Del_p.S586fs|ME3_uc009yvk.2_Frame_Shift_Del_p.S586fs	NM_001014811	NP_001014811	Q16798	MAON_HUMAN	mitochondrial malic enzyme 3 precursor	586_587					aerobic respiration|malate metabolic process|oxygen metabolic process|pyruvate metabolic process	mitochondrial matrix	malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity|metal ion binding|NAD binding			ovary(1)	1		Acute lymphoblastic leukemia(157;4.34e-06)|all_hematologic(158;0.00252)			NADH(DB00157)	TGTCCAGTGTAAAGGAGTCATAGT	0.51		NA											54	157	---	---	---	---	NA	NA	NA	NA
NR1H4	9971	broad.mit.edu	37	12	100934551	100934551	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr12:100934551delC	uc001tht.1	+	7	1091	c.1063delC	c.(1063-1065)CCGfs	p.P355fs	NR1H4_uc001thp.1_Frame_Shift_Del_p.P341fs|NR1H4_uc001thq.1_Frame_Shift_Del_p.P345fs|NR1H4_uc010svj.1_RNA|NR1H4_uc001thr.1_Frame_Shift_Del_p.P345fs|NR1H4_uc010svk.1_Frame_Shift_Del_p.P294fs|NR1H4_uc001ths.1_Frame_Shift_Del_p.P351fs	NM_005123	NP_005114	Q96RI1	NR1H4_HUMAN	nuclear receptor subfamily 1, group H, member 4	355	Ligand-binding.				bile acid metabolic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)|lung(1)|skin(1)	3						TAAGAAACTTCCGTCTGGGCA	0.378		NA											30	81	---	---	---	---	NA	NA	NA	NA
SFRS5	6430	broad.mit.edu	37	14	70238141	70238141	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr14:70238141delC	uc001xll.2	+	9	2233	c.782delC	c.(781-783)TCCfs	p.S261fs	SFRS5_uc001xlm.2_RNA|SFRS5_uc001xlo.2_Frame_Shift_Del_p.S261fs|SFRS5_uc001xlp.2_Frame_Shift_Del_p.S261fs|SFRS5_uc001xlq.2_Frame_Shift_Del_p.S258fs	NM_006925	NP_008856	Q13243	SRSF5_HUMAN	splicing factor, arginine/serine-rich 5	261	Arg/Ser-rich (RS domain).				mRNA 3'-end processing|mRNA export from nucleus|mRNA splice site selection|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|protein binding|RNA binding				0				all cancers(60;0.00144)|BRCA - Breast invasive adenocarcinoma(234;0.0132)|OV - Ovarian serous cystadenocarcinoma(108;0.0154)		AGGTCCCGGTCCCGATCAAGG	0.463		NA											70	348	---	---	---	---	NA	NA	NA	NA
ATXN3	4287	broad.mit.edu	37	14	92560173	92560173	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr14:92560173delA	uc001yac.3	-	4	306	c.237delT	c.(235-237)GTTfs	p.V79fs	ATXN3_uc010aug.2_Frame_Shift_Del_p.V64fs|ATXN3_uc001yad.3_Frame_Shift_Del_p.V24fs|ATXN3_uc010auh.2_Intron|ATXN3_uc001yae.3_Intron|ATXN3_uc010twl.1_Intron	NM_004993	NP_004984	P54252	ATX3_HUMAN	ataxin 3 reference isoform	79	Josephin.				cell death|nervous system development|nucleotide-excision repair|regulation of transcription, DNA-dependent|synaptic transmission|transcription, DNA-dependent	cytoplasm|nuclear matrix|nucleoplasm	cysteine-type peptidase activity|protein binding				0		all_cancers(154;0.0768)		COAD - Colon adenocarcinoma(157;0.224)		CATTGCTTATAACCTGTTAAG	0.353		NA											32	78	---	---	---	---	NA	NA	NA	NA
TP53	7157	broad.mit.edu	37	17	7578469	7578469	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr17:7578469delC	uc002gim.2	-	5	655	c.461delG	c.(460-462)GGCfs	p.G154fs	TP53_uc002gig.1_Frame_Shift_Del_p.G154fs|TP53_uc002gih.2_Frame_Shift_Del_p.G154fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Frame_Shift_Del_p.G22fs|TP53_uc010cng.1_Frame_Shift_Del_p.G22fs|TP53_uc002gii.1_Frame_Shift_Del_p.G22fs|TP53_uc010cnh.1_Frame_Shift_Del_p.G154fs|TP53_uc010cni.1_Frame_Shift_Del_p.G154fs|TP53_uc002gij.2_Frame_Shift_Del_p.G154fs|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Frame_Shift_Del_p.G61fs|TP53_uc002gio.2_Frame_Shift_Del_p.G22fs|TP53_uc010vug.1_Frame_Shift_Del_p.G115fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	154	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		G -> D (in sporadic cancers; somatic mutation).|G -> S (in sporadic cancers; somatic mutation).|G -> A (in sporadic cancers; somatic mutation).|G -> V (in a brain tumor with no family history; germline mutation and in sporadic cancers; somatic mutation).|G -> I (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> C (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.G154V(36)|p.G154G(12)|p.G154S(9)|p.0?(7)|p.G154D(6)|p.P152fs*14(4)|p.G154I(3)|p.G154fs*27(3)|p.G154fs*16(2)|p.G154fs*14(2)|p.P153fs*26(2)|p.P153fs*22(2)|p.P151_V173del23(1)|p.G154_R156delGTR(1)|p.G154C(1)|p.Q144_G154del11(1)|p.D148_T155delDSTPPPGT(1)|p.G154A(1)|p.S149fs*72(1)|p.G154fs*22(1)|p.D148fs*23(1)|p.P153_G154insX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GACGCGGGTGCCGGGCGGGGG	0.607		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			95	50	---	---	---	---	NA	NA	NA	NA
U2AF1	7307	broad.mit.edu	37	21	44513281	44513282	+	In_Frame_Ins	INS	-	-	CCG	rs144595259		TCGA-CR-7374-01A-11D-2012-08	TCGA-CR-7374-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2cf33b63-464e-49a0-88f0-6a6d5b0393c4	72e73761-8b51-47b3-8dae-2c103d1c6c54	g.chr21:44513281_44513282insCCG	uc002zda.1	-	8	737_738	c.653_654insCGG	c.(652-654)GGT>GGCGGT	p.218_218G>GG	U2AF1_uc002zcy.1_In_Frame_Ins_p.145_145G>GG|U2AF1_uc002zcz.1_In_Frame_Ins_p.145_145G>GG|U2AF1_uc002zdb.1_In_Frame_Ins_p.218_218G>GG|U2AF1_uc010gpi.1_3'UTR	NM_001025203	NP_001020374	Q01081	U2AF1_HUMAN	U2 small nuclear RNA auxillary factor 1 isoform	218	Arg/Gly/Ser-rich (RS domain).|Poly-Gly.				mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	Cajal body|catalytic step 2 spliceosome|nuclear speck	nucleotide binding|RNA binding|zinc ion binding				0						cgccacctccaccaccgccacc	0.406		NA											9	113	---	---	---	---	NA	NA	NA	NA