Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
KIAA0562	9731	broad.mit.edu	37	1	3740094	3740094	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:3740094C>A	uc001aky.2	-	19	2756	c.2397G>T	c.(2395-2397)TTG>TTT	p.L799F	KIAA0562_uc010nzm.1_RNA	NM_014704	NP_055519	O60308	CE104_HUMAN	glycine-, glutamate-,	799						centriole	binding				0	all_cancers(77;0.0395)|Ovarian(185;0.0634)|all_lung(157;0.222)|Lung NSC(156;0.227)	all_epithelial(116;3.96e-21)|all_lung(118;2.74e-08)|Lung NSC(185;6.4e-06)|Breast(487;0.00066)|Renal(390;0.00121)|Hepatocellular(190;0.00335)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.031)|Lung SC(97;0.0548)|Medulloblastoma(700;0.212)		Epithelial(90;6.85e-39)|OV - Ovarian serous cystadenocarcinoma(86;1.59e-22)|GBM - Glioblastoma multiforme(42;3.16e-16)|Colorectal(212;2.01e-05)|COAD - Colon adenocarcinoma(227;7.99e-05)|BRCA - Breast invasive adenocarcinoma(365;0.000389)|Kidney(185;0.000513)|STAD - Stomach adenocarcinoma(132;0.00709)|KIRC - Kidney renal clear cell carcinoma(229;0.00714)|Lung(427;0.137)		ATTCCGTCAGCAAGTGCTCCG	0.502		NA											35	30					1.31e-17	1.83e-17	1	0
CA6	765	broad.mit.edu	37	1	9019024	9019024	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:9019024C>A	uc001apm.2	+	4	488	c.464C>A	c.(463-465)GCG>GAG	p.A155E	CA6_uc009vmn.2_Missense_Mutation_p.A95E	NM_001215	NP_001206	P23280	CAH6_HUMAN	carbonic anhydrase VI precursor	155					one-carbon metabolic process	extracellular region	carbonate dehydratase activity|zinc ion binding			ovary(2)	2	Ovarian(185;0.112)|all_lung(157;0.143)	all_epithelial(116;1.02e-19)|all_lung(118;3.6e-06)|Lung NSC(185;7.94e-06)|Renal(390;0.000147)|Breast(348;0.00123)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.9e-07)|COAD - Colon adenocarcinoma(227;8.28e-05)|Kidney(185;0.000268)|KIRC - Kidney renal clear cell carcinoma(229;0.000971)|STAD - Stomach adenocarcinoma(132;0.00184)|BRCA - Breast invasive adenocarcinoma(304;0.00192)|READ - Rectum adenocarcinoma(331;0.0649)		GCCCAAGATGCGCCGGATGGT	0.428		NA											103	52					4.61e-43	7.15e-43	1	0
CROCC	9696	broad.mit.edu	37	1	17295649	17295649	+	Silent	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:17295649G>T	uc001azt.2	+	32	5184	c.5115G>T	c.(5113-5115)CTG>CTT	p.L1705L	CROCC_uc001azu.2_Silent_p.L1008L|CROCC_uc001azv.2_Silent_p.L41L	NM_014675	NP_055490	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil	1705					cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			ovary(2)|breast(2)|central_nervous_system(1)	5		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		CCCTGCAGCTGACCGTGGAGC	0.667		NA											3	11					0.004672	0.00493652	1	0
SH3BGRL3	83442	broad.mit.edu	37	1	26607338	26607338	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:26607338A>G	uc001blu.2	+	2	565	c.131A>G	c.(130-132)AAC>AGC	p.N44S		NM_031286	NP_112576	Q9H299	SH3L3_HUMAN	SH3 domain binding glutamic acid-rich protein	44	Glutaredoxin.				cell redox homeostasis	cytoplasm|nucleus	electron carrier activity|protein disulfide oxidoreductase activity				0		all_cancers(24;1.16e-23)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.22e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|BRCA - Breast invasive adenocarcinoma(304;0.000946)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00751)|READ - Rectum adenocarcinoma(331;0.0649)		TCCCAGGACAACGCCCTGAGG	0.617		NA											18	10					0	0	0	0
CSMD2	114784	broad.mit.edu	37	1	34123627	34123627	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:34123627C>T	uc001bxn.1	-	27	4275	c.4246G>A	c.(4246-4248)GCG>ACG	p.A1416T	CSMD2_uc001bxm.1_Missense_Mutation_p.A1456T|CSMD2_uc001bxo.1_Missense_Mutation_p.A329T	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1416	Extracellular (Potential).|Sushi 8.					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CCCTGCAGCGCGTAGCCAGGG	0.592		NA											44	22					0	0	0	0
CSMD2	114784	broad.mit.edu	37	1	34174731	34174731	+	Silent	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:34174731C>T	uc001bxn.1	-	22	3443	c.3414G>A	c.(3412-3414)CTG>CTA	p.L1138L	CSMD2_uc001bxm.1_Silent_p.L1178L|CSMD2_uc001bxo.1_Silent_p.L51L	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1138	Extracellular (Potential).|CUB 7.					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CCCTGGCTTTCAGCTGAATTC	0.443		NA											8	60					0	0	0	0
TMEM125	128218	broad.mit.edu	37	1	43738818	43738818	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:43738818G>T	uc001cir.2	+	4	995	c.425G>T	c.(424-426)CGG>CTG	p.R142L	EBNA1BP2_uc001cio.2_5'Flank|TMEM125_uc001cis.2_Missense_Mutation_p.R142L	NM_144626	NP_653227	Q96AQ2	TM125_HUMAN	transmembrane protein 125	142						integral to membrane				breast(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GCCCCTGCTCGGCCGCTGGCC	0.706		NA											9	5					2.74e-10	3.5e-10	1	0
PCSK9	255738	broad.mit.edu	37	1	55518372	55518372	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:55518372G>A	uc001cyf.1	+	5	998	c.707G>A	c.(706-708)GGC>GAC	p.G236D	PCSK9_uc010ool.1_RNA|PCSK9_uc010oom.1_RNA	NM_174936	NP_777596	Q8NBP7	PCSK9_HUMAN	proprotein convertase subtilisin/kexin type 9	236	Peptidase S8.				cellular response to insulin stimulus|cellular response to starvation|cholesterol homeostasis|cholesterol metabolic process|kidney development|liver development|low-density lipoprotein particle receptor catabolic process|lysosomal transport|negative regulation of catalytic activity|negative regulation of low-density lipoprotein particle clearance|negative regulation of receptor recycling|neuron differentiation|positive regulation of neuron apoptosis|positive regulation of receptor internalization|protein autoprocessing|regulation of receptor activity	extracellular space|late endosome|lysosome|perinuclear region of cytoplasm	apolipoprotein receptor binding|identical protein binding|low-density lipoprotein particle receptor binding|serine-type endopeptidase activity|very-low-density lipoprotein particle receptor binding			ovary(2)|central_nervous_system(1)|skin(1)	4						GTGGTCAGCGGCCGGGATGCC	0.637		NA											25	11					0	0	0	0
INADL	10207	broad.mit.edu	37	1	62340990	62340990	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:62340990G>T	uc001dab.2	+	21	3025	c.2911G>T	c.(2911-2913)GAC>TAC	p.D971Y	INADL_uc009waf.1_Missense_Mutation_p.D971Y|INADL_uc001daa.2_Missense_Mutation_p.D971Y|INADL_uc001dad.3_Missense_Mutation_p.D668Y|INADL_uc001dac.2_RNA	NM_176877	NP_795352	Q8NI35	INADL_HUMAN	InaD-like	971					intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			ovary(3)|skin(1)	4						AGGCAGATTTGACGACCTGGA	0.338		NA											34	13					7.83e-31	1.19e-30	1	0
C1orf173	127254	broad.mit.edu	37	1	75072536	75072536	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:75072536C>A	uc001dgg.2	-	10	1457	c.1238G>T	c.(1237-1239)AGG>ATG	p.R413M	uc001dgh.2_Intron|C1orf173_uc001dgi.3_Missense_Mutation_p.R207M	NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	413										ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						CTTTTCTTTCCTAGATTTCGG	0.408		NA											47	34					2.48e-22	3.65e-22	1	0
WDR63	126820	broad.mit.edu	37	1	85561694	85561694	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:85561694C>G	uc001dkt.2	+	11	1445	c.1254C>G	c.(1252-1254)ATC>ATG	p.I418M	WDR63_uc009wcl.2_Missense_Mutation_p.I379M	NM_145172	NP_660155	Q8IWG1	WDR63_HUMAN	WD repeat domain 63	418	WD 1.									upper_aerodigestive_tract(2)|ovary(2)|skin(1)	5				all cancers(265;0.00391)|Epithelial(280;0.00922)|Colorectal(170;0.166)		GAGGCTGTATCAATGGGCAGG	0.393		NA											31	19					0	0	0	0
HFM1	164045	broad.mit.edu	37	1	91843694	91843694	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:91843694A>G	uc001doa.3	-	11	1383	c.1283T>C	c.(1282-1284)GTA>GCA	p.V428A	HFM1_uc010osu.1_Missense_Mutation_p.V107A|HFM1_uc010osv.1_Missense_Mutation_p.V112A|HFM1_uc001doc.1_Missense_Mutation_p.V428A	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein	428	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		TCTGCTAACTACAACTTCAAG	0.318		NA											19	16					0	0	0	0
COL11A1	1301	broad.mit.edu	37	1	103462681	103462681	+	Splice_Site	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:103462681C>T	uc001dul.2	-	26	2515	c.2197_splice	c.e26-1	p.G733_splice	COL11A1_uc001duk.2_Splice_Site|COL11A1_uc001dum.2_Splice_Site_p.G745_splice|COL11A1_uc001dun.2_Splice_Site_p.G694_splice|COL11A1_uc009weh.2_Splice_Site_p.G617_splice	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A						collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CAGGATGACCCTATATTTAGC	0.318		NA											100	51					0	0	0	0
COL11A1	1301	broad.mit.edu	37	1	103487279	103487279	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:103487279G>T	uc001dul.2	-	9	1610	c.1292C>A	c.(1291-1293)CCA>CAA	p.P431Q	COL11A1_uc001duk.2_5'UTR|COL11A1_uc001dum.2_Missense_Mutation_p.P443Q|COL11A1_uc001dun.2_Missense_Mutation_p.P392Q|COL11A1_uc009weh.2_Missense_Mutation_p.P315Q	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	431	Triple-helical region (interrupted).				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		AACCACTGCTGGTTCTCCTTT	0.353		NA											29	20					2e-19	2.86e-19	1	0
PDE4DIP	9659	broad.mit.edu	37	1	145075791	145075791	+	Silent	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:145075791G>T	uc001emh.2	-	1	289	c.72C>A	c.(70-72)CGC>CGA	p.R24R	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elo.2_Silent_p.R24R|PDE4DIP_uc001emk.2_Silent_p.R24R	NM_022359	NP_071754	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	Error:Variant_position_missing_in_Q5VU43_after_alignment					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		AGTGAGCCCGGCGGGACGCGC	0.716		NA	T	PDGFRB	MPD								17	85					1.37e-18	1.93e-18	1	0
CHD1L	9557	broad.mit.edu	37	1	146747865	146747865	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:146747865G>C	uc001epm.3	+	14	1546	c.1483G>C	c.(1483-1485)GAA>CAA	p.E495Q	uc001epp.2_Intron|CHD1L_uc001epn.3_Missense_Mutation_p.E382Q|CHD1L_uc010ozo.1_RNA|CHD1L_uc009wjg.2_RNA|CHD1L_uc009wjh.2_Missense_Mutation_p.E401Q|CHD1L_uc010ozp.1_Missense_Mutation_p.E214Q|CHD1L_uc001epo.3_Missense_Mutation_p.E291Q|CHD1L_uc010ozq.1_Missense_Mutation_p.E68Q|CHD1L_uc009wji.2_Missense_Mutation_p.E214Q	NM_004284	NP_004275	Q86WJ1	CHD1L_HUMAN	chromodomain helicase DNA binding protein	495	Helicase C-terminal.				chromatin remodeling|DNA repair	cytoplasm|nucleus|plasma membrane	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			ovary(3)|lung(2)|upper_aerodigestive_tract(1)	6	all_hematologic(923;0.0487)					CATGATCATAGAAGGAGGCCA	0.453		NA											6	102					0	0	0	0
FAM63A	55793	broad.mit.edu	37	1	150974945	150974945	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:150974945C>A	uc001ewf.2	-	3	1833	c.149G>T	c.(148-150)CGG>CTG	p.R50L	FAM63A_uc001ewc.2_Intron|FAM63A_uc010pcm.1_Intron|FAM63A_uc001ewd.2_Intron|FAM63A_uc001ewe.2_Intron|FAM63A_uc010pcn.1_Missense_Mutation_p.R98L|FAM63A_uc001ewg.2_Missense_Mutation_p.R50L	NM_018379	NP_001156731	Q8N5J2	FA63A_HUMAN	hypothetical protein LOC55793 isoform 1	50							protein binding			ovary(1)	1	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			TGCTGGCTCCCGTTCTCTAGC	0.592		NA											20	248					7.45e-12	9.78e-12	1	0
S100A11	6282	broad.mit.edu	37	1	152005294	152005294	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:152005294C>G	uc001ezn.2	-	3	282	c.162G>C	c.(160-162)CAG>CAC	p.Q54H	uc001ezm.1_Intron	NM_005620	NP_005611	P31949	S10AB_HUMAN	S100 calcium binding protein A11	54					negative regulation of cell proliferation|negative regulation of DNA replication|signal transduction	cytoplasm|nucleus|ruffle	calcium ion binding|calcium-dependent protein binding|protein homodimerization activity|S100 beta binding				0	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			CAGGGTCCTTCTGGTTCTGCA	0.269		NA											29	52					0	0	0	0
DCST2	127579	broad.mit.edu	37	1	155004083	155004083	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:155004083G>A	uc001fgm.2	-	4	786	c.706C>T	c.(706-708)CCC>TCC	p.P236S	DCST2_uc009wpb.2_RNA|DCST1_uc010per.1_5'Flank|DCST1_uc001fgn.1_5'Flank|DCST1_uc010pes.1_5'Flank	NM_144622	NP_653223	Q5T1A1	DCST2_HUMAN	DC-STAMP domain containing 2	236	Helical; (Potential).					integral to membrane				ovary(2)|central_nervous_system(1)	3	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			AGTTTGAAGGGCATGAGCACG	0.512		NA											32	76					0	0	0	0
SYT11	23208	broad.mit.edu	37	1	155837912	155837912	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:155837912T>C	uc001fmg.2	+	2	454	c.191T>C	c.(190-192)ATA>ACA	p.I64T	SYT11_uc010pgq.1_Intron	NM_152280	NP_689493	Q9BT88	SYT11_HUMAN	synaptotagmin XI	64	Cytoplasmic (Potential).					cell junction|synaptic vesicle membrane	protein binding|transporter activity			ovary(1)|skin(1)	2	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;0.000162)			GGCATCAGCATATACCCAGAG	0.502		NA											33	70					0	0	0	0
CD1E	913	broad.mit.edu	37	1	158325824	158325824	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:158325824G>C	uc001fse.2	+	4	1072	c.833G>C	c.(832-834)GGG>GCG	p.G278A	CD1E_uc010pid.1_Missense_Mutation_p.G276A|CD1E_uc010pie.1_Missense_Mutation_p.G179A|CD1E_uc010pif.1_Missense_Mutation_p.G89A|CD1E_uc001fsd.2_Intron|CD1E_uc001fsk.2_Missense_Mutation_p.G188A|CD1E_uc001fsj.2_Intron|CD1E_uc001fsc.2_Missense_Mutation_p.G89A|CD1E_uc010pig.1_Intron|CD1E_uc001fsa.2_Intron|CD1E_uc001fsf.2_Missense_Mutation_p.G278A|CD1E_uc001fry.2_Intron|CD1E_uc001fsg.2_Intron|CD1E_uc001fsh.2_Missense_Mutation_p.G89A|CD1E_uc001fsi.2_Intron|CD1E_uc009wsv.2_Missense_Mutation_p.G179A|CD1E_uc001frz.2_Missense_Mutation_p.G188A|CD1E_uc009wsw.2_Missense_Mutation_p.G36A	NM_030893	NP_112155	P15812	CD1E_HUMAN	CD1E antigen isoform a precursor	278	Ig-like.				antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				skin(3)	3	all_hematologic(112;0.0378)					GTGGCGGCTGGGGAGGCAGCT	0.607		NA											39	64					0	0	0	0
OR10K1	391109	broad.mit.edu	37	1	158435444	158435444	+	Silent	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:158435444C>T	uc010pij.1	+	1	93	c.93C>T	c.(91-93)TTC>TTT	p.F31F		NM_001004473	NP_001004473	Q8NGX5	O10K1_HUMAN	olfactory receptor, family 10, subfamily K,	31	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					TTGTTATCTTCCTGCTCCTCT	0.517		NA											40	65					0	0	0	0
SPTA1	6708	broad.mit.edu	37	1	158582607	158582607	+	Silent	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:158582607C>T	uc001fst.1	-	51	7333	c.7134G>A	c.(7132-7134)CAG>CAA	p.Q2378Q		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	2378	EF-hand 3.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					AGAATCGGACCTGCTTCATGT	0.458		NA											26	51					0	0	0	0
SPTA1	6708	broad.mit.edu	37	1	158627344	158627344	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:158627344C>G	uc001fst.1	-	19	2927	c.2728G>C	c.(2728-2730)GAA>CAA	p.E910Q		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	910	Spectrin 10.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					GTTTCTGCTTCATGCAGGTCA	0.473		NA											71	111					0	0	0	0
DARC	2532	broad.mit.edu	37	1	159175930	159175930	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:159175930C>A	uc001fto.2	+	2	941	c.701C>A	c.(700-702)GCA>GAA	p.A234E	DARC_uc001ftp.3_Missense_Mutation_p.A236E	NM_002036	NP_002027	Q16570	DUFFY_HUMAN	Duffy blood group antigen isoform b	234	Cytoplasmic (Potential).				defense response	integral to membrane|plasma membrane	C-C chemokine binding|chemokine receptor activity			ovary(1)|lung(1)	2	all_hematologic(112;0.0429)					CTGAAGAAGGCATTGGGTATG	0.542		NA											26	62					6.13e-19	8.71e-19	1	0
DEDD	9191	broad.mit.edu	37	1	161093691	161093691	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:161093691C>G	uc001fxz.2	-	4	544	c.371G>C	c.(370-372)CGC>CCC	p.R124P	NIT1_uc001fxw.2_Intron|DEDD_uc009wty.2_Missense_Mutation_p.R124P|DEDD_uc001fya.2_Missense_Mutation_p.R124P|DEDD_uc001fyb.2_Missense_Mutation_p.R124P|DEDD_uc010pkb.1_Missense_Mutation_p.R81P|DEDD_uc001fyc.2_5'UTR	NM_001039712	NP_001034801	O75618	DEDD_HUMAN	death effector domain-containing protein	124					apoptosis|induction of apoptosis via death domain receptors|negative regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding				0	all_cancers(52;3.39e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)			GGTCACATAGCGAATTGATGT	0.483		NA											37	97					0	0	0	0
DDR2	4921	broad.mit.edu	37	1	162731083	162731083	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:162731083G>T	uc001gcf.2	+	10	1403	c.938G>T	c.(937-939)TGG>TTG	p.W313L	DDR2_uc001gcg.2_Missense_Mutation_p.W313L	NM_001014796	NP_001014796	Q16832	DDR2_HUMAN	discoidin domain receptor family, member 2	313	Extracellular (Potential).				cell adhesion	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(2)|central_nervous_system(2)|ovary(1)|kidney(1)	6	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.113)			GCCAGTGAGTGGGAACCTAAT	0.527		NA											28	30					2.13e-12	2.82e-12	1	0
C1orf110	339512	broad.mit.edu	37	1	162824618	162824618	+	Silent	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:162824618G>A	uc001gck.2	-	4	1021	c.846C>T	c.(844-846)TCC>TCT	p.S282S	C1orf110_uc009wuw.1_Intron|C1orf110_uc009wux.1_Silent_p.S281S	NM_178550	NP_848645	Q86UF4	CA110_HUMAN	hypothetical protein LOC339512	282											0						TGGATGATGAGGATTCCCCAT	0.473		NA											50	71					0	0	0	0
FAM5B	57795	broad.mit.edu	37	1	177226407	177226407	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:177226407A>T	uc001glf.2	+	4	868	c.556A>T	c.(556-558)AGC>TGC	p.S186C	FAM5B_uc010pna.1_5'UTR|FAM5B_uc001glg.2_Missense_Mutation_p.S81C	NM_021165	NP_066988	Q9C0B6	FAM5B_HUMAN	family with sequence similarity 5, member B	186						extracellular region				skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6						CAGTGGGAACAGCACAGCTGT	0.557		NA											16	33					0	0	0	0
CEP350	9857	broad.mit.edu	37	1	180006140	180006140	+	Silent	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:180006140G>T	uc001gnt.2	+	17	4409	c.4026G>T	c.(4024-4026)TCG>TCT	p.S1342S	CEP350_uc009wxl.2_Silent_p.S1341S|CEP350_uc001gnu.2_Silent_p.S1175S	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	1342						centrosome|nucleus|spindle				ovary(4)	4						TTGAGGAGTCGGTGCGCCAAC	0.468		NA											7	7					5.49e-09	6.85e-09	1	0
CACNA1E	777	broad.mit.edu	37	1	181690908	181690908	+	Silent	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:181690908G>A	uc001gow.2	+	16	2136	c.1971G>A	c.(1969-1971)GAG>GAA	p.E657E	CACNA1E_uc009wxs.2_Silent_p.E564E	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	657	Extracellular (Potential).|II.	Calcium ion selectivity and permeability (By similarity).			energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						TGACGGGTGAGGACTGGAATG	0.542		NA											54	122					0	0	0	0
UCHL5	51377	broad.mit.edu	37	1	193028325	193028325	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:193028325A>C	uc001gsm.2	-	1	197	c.66T>G	c.(64-66)ATT>ATG	p.I22M	UCHL5_uc001gsn.2_RNA|UCHL5_uc001gso.2_Missense_Mutation_p.I22M|UCHL5_uc010pov.1_RNA|UCHL5_uc001gsp.2_Missense_Mutation_p.I22M|UCHL5_uc001gsq.2_Missense_Mutation_p.I22M|UCHL5_uc010pow.1_Intron|UCHL5_uc010pox.1_Translation_Start_Site|UCHL5_uc001gsr.1_3'UTR|TROVE2_uc001gst.1_5'Flank|TROVE2_uc001gss.2_5'Flank|TROVE2_uc001gsu.1_5'Flank|TROVE2_uc001gsv.1_5'Flank|TROVE2_uc001gsw.2_5'Flank|TROVE2_uc009wyp.2_5'Flank|TROVE2_uc009wyq.2_5'Flank	NM_015984	NP_057068	Q9Y5K5	UCHL5_HUMAN	ubiquitin carboxyl-terminal hydrolase L5	22					DNA recombination|DNA repair|protein deubiquitination|regulation of proteasomal protein catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytosol|Ino80 complex|proteasome complex	endopeptidase inhibitor activity|omega peptidase activity|proteasome binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(2)|ovary(1)	3						CGAATCCTTTAATGAGCTCGG	0.677		NA											14	7					0	0	0	0
KCNT2	343450	broad.mit.edu	37	1	196227558	196227558	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:196227558G>T	uc001gtd.1	-	26	3037	c.2977C>A	c.(2977-2979)CGC>AGC	p.R993S	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Missense_Mutation_p.R926S|KCNT2_uc001gtf.1_Missense_Mutation_p.R969S|KCNT2_uc001gtg.1_RNA|KCNT2_uc001gth.1_Missense_Mutation_p.R497S	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	993	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						TGGTTGCTGCGGTGGTGCCCT	0.468		NA											40	79					6.49e-15	8.88e-15	1	0
CRB1	23418	broad.mit.edu	37	1	197404354	197404354	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:197404354C>A	uc001gtz.2	+	9	3496	c.3361C>A	c.(3361-3363)CAG>AAG	p.Q1121K	CRB1_uc010poz.1_Missense_Mutation_p.Q1097K|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Missense_Mutation_p.Q1009K|CRB1_uc010ppb.1_Intron|CRB1_uc010ppd.1_Missense_Mutation_p.Q602K|CRB1_uc001gub.1_Missense_Mutation_p.Q770K	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	1121	Extracellular (Potential).|Laminin G-like 3.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						TAATAAACCTCAGGAAGAGCA	0.398		NA											30	72					1.14e-10	1.46e-10	1	0
SLC26A9	115019	broad.mit.edu	37	1	205900999	205900999	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:205900999C>G	uc001hdq.2	-	5	655	c.541G>C	c.(541-543)GCC>CCC	p.A181P	SLC26A9_uc001hdp.2_Missense_Mutation_p.A181P	NM_052934	NP_443166	Q7LBE3	S26A9_HUMAN	solute carrier family 26, member 9 isoform a	181	Helical; (Potential).					integral to membrane	chloride channel activity|secondary active sulfate transmembrane transporter activity			ovary(1)|skin(1)	2	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0458)			TGGATGATGGCGGTGAGGCAG	0.562		NA											21	31					0	0	0	0
PIGR	5284	broad.mit.edu	37	1	207106357	207106357	+	Silent	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:207106357C>A	uc001hez.2	-	7	2044	c.1860G>T	c.(1858-1860)GGG>GGT	p.G620G	PIGR_uc009xbz.2_Silent_p.G620G	NM_002644	NP_002635	P01833	PIGR_HUMAN	polymeric immunoglobulin receptor precursor	620	Extracellular (Potential).					extracellular region|integral to plasma membrane	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3						ATGCTCTGCTCCCATCGGCTT	0.557		NA											25	63					3.65e-15	5.02e-15	1	0
CAMK1G	57172	broad.mit.edu	37	1	209781228	209781228	+	Silent	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:209781228C>A	uc001hhd.2	+	7	687	c.585C>A	c.(583-585)CCC>CCA	p.P195P	CAMK1G_uc001hhf.3_Silent_p.P195P|CAMK1G_uc001hhe.2_Silent_p.P195P	NM_020439	NP_065172	Q96NX5	KCC1G_HUMAN	calcium/calmodulin-dependent protein kinase IG	195	Protein kinase.					Golgi membrane|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0475)		CCCAGAAACCCTACAGCAAGG	0.597		NA											56	87					3.89e-19	5.58e-19	1	0
C1orf107	27042	broad.mit.edu	37	1	210006693	210006693	+	Silent	SNP	A	A	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:210006693A>G	uc001hhr.1	+	4	628	c.552A>G	c.(550-552)AAA>AAG	p.K184K	C1orf107_uc009xcu.1_5'UTR	NM_014388	NP_055203	Q68CQ4	DIEXF_HUMAN	digestive-organ expansion factor homolog	184					multicellular organismal development	nucleus					0				OV - Ovarian serous cystadenocarcinoma(81;0.0367)		CTTCTTTGAAAGCCTCTCAAG	0.398		NA											44	85					0	0	0	0
KCNH1	3756	broad.mit.edu	37	1	211093374	211093374	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:211093374C>A	uc001hib.2	-	7	1240	c.1070G>T	c.(1069-1071)CGG>CTG	p.R357L	KCNH1_uc001hic.2_Missense_Mutation_p.R330L	NM_172362	NP_758872	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H,	357	Helical; Voltage-sensor; Name=Segment S4; (Potential).				myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			ovary(4)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		ACGGAGCAGCCGGACAACTTT	0.567		NA											29	62					6.39e-12	8.41e-12	1	0
PROX1	5629	broad.mit.edu	37	1	214170119	214170119	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:214170119G>A	uc001hkh.2	+	2	513	c.241G>A	c.(241-243)GAA>AAA	p.E81K	PROX1_uc001hkg.1_Missense_Mutation_p.E81K	NM_002763	NP_002754	Q92786	PROX1_HUMAN	prospero homeobox 1	81					aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of S phase of mitotic cell cycle|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			ovary(3)|lung(1)|central_nervous_system(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)		GAACTCGTATGAAGATGCCAT	0.478		NA											9	71					0	0	0	0
PROX1	5629	broad.mit.edu	37	1	214170863	214170863	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:214170863G>A	uc001hkh.2	+	2	1257	c.985G>A	c.(985-987)GGC>AGC	p.G329S	PROX1_uc001hkg.1_Missense_Mutation_p.G329S	NM_002763	NP_002754	Q92786	PROX1_HUMAN	prospero homeobox 1	329					aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of S phase of mitotic cell cycle|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			ovary(3)|lung(1)|central_nervous_system(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)		GAAGCGAGAAGGCAACAACAA	0.493		NA											9	50					0	0	0	0
USH2A	7399	broad.mit.edu	37	1	215955411	215955411	+	Silent	SNP	C	C	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:215955411C>G	uc001hku.1	-	54	11100	c.10713G>C	c.(10711-10713)ACG>ACC	p.T3571T		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	3571	Extracellular (Potential).|Fibronectin type-III 20.		T -> M (in USH2A).		maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AGCCAGCAACCGTGCAAGCTT	0.443		NA								HNSCC(13;0.011)			37	62					0	0	0	0
USH2A	7399	broad.mit.edu	37	1	216258127	216258127	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:216258127G>T	uc001hku.1	-	25	5467	c.5080C>A	c.(5080-5082)CAG>AAG	p.Q1694K		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	1694	Laminin G-like 1.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TCAGAACTCTGCCAATCCAGA	0.433		NA								HNSCC(13;0.011)			54	88					3.46e-24	5.16e-24	1	0
SPATA17	128153	broad.mit.edu	37	1	217822275	217822275	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:217822275A>T	uc001hlh.1	+	2	146	c.120A>T	c.(118-120)CAA>CAT	p.Q40H	SPATA17_uc009xdr.1_RNA|SPATA17_uc001hli.2_Missense_Mutation_p.Q40H	NM_138796	NP_620151	Q96L03	SPT17_HUMAN	spermatogenesis associated 17	40	IQ 1.					cytoplasm	calmodulin binding			pancreas(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0516)|all cancers(67;0.0891)|GBM - Glioblastoma multiforme(131;0.117)		TTAAAATCCAAAGCTGGTTTC	0.303		NA											25	60					0	0	0	0
TRIM67	440730	broad.mit.edu	37	1	231335944	231335944	+	Silent	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:231335944C>T	uc009xfn.1	+	4	1356	c.1314C>T	c.(1312-1314)ACC>ACT	p.T438T		NM_001004342	NP_001004342	Q6ZTA4	TRI67_HUMAN	tripartite motif-containing 67	438						cytoplasm|cytoskeleton	zinc ion binding			ovary(2)|breast(1)|kidney(1)	4	Breast(184;0.0871)	all_cancers(173;0.189)|Prostate(94;0.167)				GTCAGTCCACCGGACTGATGG	0.522		NA											14	147					0	0	0	0
RBM34	23029	broad.mit.edu	37	1	235324273	235324273	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:235324273G>A	uc001hwn.2	-	2	193	c.163C>T	c.(163-165)CGG>TGG	p.R55W	RBM34_uc001hwo.2_RNA|ARID4B_uc001hwp.2_RNA|RBM34_uc010pxp.1_Missense_Mutation_p.R55W	NM_015014	NP_055829	P42696	RBM34_HUMAN	RNA binding motif protein 34 isoform 1	55						nucleolus	nucleotide binding|RNA binding			central_nervous_system(1)	1	Ovarian(103;0.0398)	all_cancers(173;0.177)|Prostate(94;0.0166)	OV - Ovarian serous cystadenocarcinoma(106;5.43e-05)|Epithelial(3;0.000121)			GACGCCAGCCGACCGGTGCCA	0.587		NA											16	61					0	0	0	0
RYR2	6262	broad.mit.edu	37	1	237774236	237774236	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:237774236C>A	uc001hyl.1	+	36	4978	c.4858C>A	c.(4858-4860)CAG>AAG	p.Q1620K		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1620	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CTGGTTGGTGCAGTGTTTGGA	0.502		NA											5	14					2.01e-06	2.35e-06	1	0
RYR2	6262	broad.mit.edu	37	1	237817705	237817705	+	Silent	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:237817705G>T	uc001hyl.1	+	52	8076	c.7956G>T	c.(7954-7956)CTG>CTT	p.L2652L		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2652	Modulator (Potential).|Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TTGATGCCCTGTCTCAAAAGG	0.378		NA											11	24					2.81e-09	3.52e-09	1	0
RYR2	6262	broad.mit.edu	37	1	237843850	237843850	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:237843850C>G	uc001hyl.1	+	62	9110	c.8990C>G	c.(8989-8991)TCC>TGC	p.S2997C	RYR2_uc010pxz.1_5'UTR	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2997	Modulator (Potential).|Cytoplasmic (By similarity).|Calmodulin-binding (Potential).				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GGACATGCTTCCAACAAAGAG	0.388		NA											9	8					0	0	0	0
FMN2	56776	broad.mit.edu	37	1	240370334	240370334	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:240370334C>T	uc010pyd.1	+	5	2447	c.2222C>T	c.(2221-2223)GCG>GTG	p.A741V	FMN2_uc010pye.1_Missense_Mutation_p.A745V	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	741					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			ATTTTAGAGGCGAAATCGATA	0.567		NA											10	27					0	0	0	0
CHML	1122	broad.mit.edu	37	1	241798273	241798273	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:241798273G>C	uc001hzd.2	-	1	960	c.796C>G	c.(796-798)CTT>GTT	p.L266V	OPN3_uc001hza.2_Intron|OPN3_uc001hzb.2_Intron|OPN3_uc001hzc.2_Intron	NM_001821	NP_001812	P26374	RAE2_HUMAN	choroideremia-like Rab escort protein 2	266					intracellular protein transport|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity			ovary(4)|skin(2)	6	Ovarian(103;0.103)|all_lung(81;0.23)	all_cancers(173;0.0231)	OV - Ovarian serous cystadenocarcinoma(106;0.0125)			CGAAATGCAAGAATCCTAGTG	0.358		NA											19	36					0	0	0	0
OR2G3	81469	broad.mit.edu	37	1	247769784	247769784	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:247769784G>C	uc010pyz.1	+	1	897	c.897G>C	c.(895-897)GAG>GAC	p.E299D		NM_001001914	NP_001001914	Q8NGZ4	OR2G3_HUMAN	olfactory receptor, family 2, subfamily G,	299	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			ATATGAAAGAGGCTCTGAGGA	0.408		NA											39	76					0	0	0	0
OR2L3	391192	broad.mit.edu	37	1	248224349	248224349	+	Silent	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:248224349C>T	uc001idx.1	+	1	366	c.366C>T	c.(364-366)TAC>TAT	p.Y122Y	OR2L13_uc001ids.2_Intron	NM_001004687	NP_001004687	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L,	122	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			ATGATCGTTACATTGCTATTT	0.448		NA											100	141					0	0	0	0
OR2M2	391194	broad.mit.edu	37	1	248343675	248343675	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:248343675C>A	uc010pzf.1	+	1	388	c.388C>A	c.(388-390)CTA>ATA	p.L130I		NM_001004688	NP_001004688	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M,	130	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TTGCCACCCTCTAAGATATAC	0.403		NA											133	263					1.15e-51	1.8e-51	1	0
OR2M7	391196	broad.mit.edu	37	1	248487047	248487047	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:248487047G>A	uc010pzk.1	-	1	824	c.824C>T	c.(823-825)TCT>TTT	p.S275F		NM_001004691	NP_001004691	Q8NG81	OR2M7_HUMAN	olfactory receptor, family 2, subfamily M,	275	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GTAGAATACAGACACCATCTT	0.463		NA											43	64					0	0	0	0
OR2T10	127069	broad.mit.edu	37	1	248756557	248756557	+	Silent	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:248756557G>A	uc010pzn.1	-	1	513	c.513C>T	c.(511-513)TCC>TCT	p.S171S		NM_001004693	NP_001004693	Q8NGZ9	O2T10_HUMAN	olfactory receptor, family 2, subfamily T,	171	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GAATCTCATGGGATCTGCAGA	0.502		NA											49	94					0	0	0	0
LARP4B	23185	broad.mit.edu	37	10	875449	875449	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr10:875449T>A	uc001ifs.1	-	10	1042	c.1001A>T	c.(1000-1002)CAG>CTG	p.Q334L		NM_015155	NP_055970	Q92615	LAR4B_HUMAN	La ribonucleoprotein domain family, member 4B	334							nucleotide binding|RNA binding			ovary(2)|central_nervous_system(1)	3						GTAGCGCTGCTGGGCATACAG	0.517		NA											38	19					0	0	0	0
TAF3	83860	broad.mit.edu	37	10	8006089	8006089	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr10:8006089G>A	uc010qbd.1	+	3	616	c.616G>A	c.(616-618)GAT>AAT	p.D206N		NM_031923	NP_114129	Q5VWG9	TAF3_HUMAN	RNA polymerase II transcription factor TAFII140	206					maintenance of protein location in nucleus|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	transcription factor TFIID complex	protein binding|zinc ion binding			ovary(1)	1						GGACACGCTAGATGTTGTGTT	0.478		NA											36	28					0	0	0	0
ARMC3	219681	broad.mit.edu	37	10	23248003	23248003	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr10:23248003T>A	uc001irm.3	+	5	380	c.297T>A	c.(295-297)GAT>GAA	p.D99E	ARMC3_uc010qcv.1_Missense_Mutation_p.D99E|ARMC3_uc010qcw.1_5'UTR|ARMC3_uc001irn.1_Missense_Mutation_p.D11E	NM_173081	NP_775104	Q5W041	ARMC3_HUMAN	armadillo repeat containing 3	99	ARM 3.						binding				0						TTGTAGATGATGTTAAAAAAT	0.229		NA											30	27					0	0	0	0
PARD3	56288	broad.mit.edu	37	10	34671813	34671813	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr10:34671813T>C	uc010qej.1	-	9	1054	c.1054A>G	c.(1054-1056)ATC>GTC	p.I352V	PARD3_uc010qek.1_Missense_Mutation_p.I352V|PARD3_uc010qel.1_Missense_Mutation_p.I352V|PARD3_uc010qem.1_Missense_Mutation_p.I352V|PARD3_uc010qen.1_Missense_Mutation_p.I352V|PARD3_uc010qeo.1_Missense_Mutation_p.I352V|PARD3_uc010qep.1_Missense_Mutation_p.I308V|PARD3_uc010qeq.1_Missense_Mutation_p.I308V|PARD3_uc001ixo.1_Missense_Mutation_p.I82V|PARD3_uc001ixp.1_Missense_Mutation_p.I217V|PARD3_uc001ixq.1_Missense_Mutation_p.I352V|PARD3_uc001ixr.1_Missense_Mutation_p.I352V|PARD3_uc001ixt.1_Missense_Mutation_p.I173V|PARD3_uc001ixu.1_Missense_Mutation_p.I308V|PARD3_uc001ixs.1_Missense_Mutation_p.I5V	NM_019619	NP_062565	Q8TEW0	PARD3_HUMAN	partitioning-defective protein 3 homolog	352	PDZ 1.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			ovary(1)	1		Breast(68;0.0707)				AACCAAATGATGGGTGTACGC	0.398		NA											66	50					0	0	0	0
ZNF32	7580	broad.mit.edu	37	10	44140211	44140211	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr10:44140211C>T	uc001jbb.2	-	3	298	c.109G>A	c.(109-111)GAG>AAG	p.E37K	uc001jba.2_Intron|ZNF32_uc001jbc.2_Missense_Mutation_p.E37K	NM_001005368	NP_001005368	P17041	ZNF32_HUMAN	zinc finger protein 32	37					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)	1		all_neural(218;0.0182)|Ovarian(717;0.0443)|Renal(717;0.157)		Lung(62;0.179)		CCTGTAGCCTCAGAGTGGTCA	0.418		NA											14	90					0	0	0	0
CHAT	1103	broad.mit.edu	37	10	50863176	50863176	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr10:50863176C>T	uc001jhz.2	+	12	1823	c.1670C>T	c.(1669-1671)GCG>GTG	p.A557V	CHAT_uc001jhv.1_Missense_Mutation_p.A439V|CHAT_uc001jhx.1_Missense_Mutation_p.A439V|CHAT_uc001jhy.1_Missense_Mutation_p.A439V|CHAT_uc001jia.2_Missense_Mutation_p.A439V|CHAT_uc010qgs.1_Missense_Mutation_p.A439V	NM_020549	NP_065574	P28329	CLAT_HUMAN	choline acetyltransferase isoform 2	557					neurotransmitter biosynthetic process|neurotransmitter secretion	cytosol|nucleus	choline O-acetyltransferase activity			central_nervous_system(3)	3		all_neural(218;0.107)		GBM - Glioblastoma multiforme(2;0.000585)	Choline(DB00122)	TACGAGAGCGCGTCCATCCGC	0.547		NA											15	45					0	0	0	0
DUPD1	338599	broad.mit.edu	37	10	76803730	76803730	+	Silent	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr10:76803730C>T	uc001jwq.1	-	2	246	c.246G>A	c.(244-246)ACG>ACA	p.T82T		NM_001003892	NP_001003892	Q68J44	DUPD1_HUMAN	dual specificity phosphatase and pro isomerase	82	Tyrosine-protein phosphatase.					cytoplasm	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)	2	all_cancers(46;0.0207)|all_epithelial(25;0.00126)|Prostate(51;0.0112)|Ovarian(15;0.0348)					TCAGCACGTGCGTGAACCCCG	0.711		NA											13	13					0	0	0	0
MAT1A	4143	broad.mit.edu	37	10	82039969	82039969	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr10:82039969G>C	uc001kbw.2	-	5	764	c.509C>G	c.(508-510)TCC>TGC	p.S170C		NM_000429	NP_000420	Q00266	METK1_HUMAN	methionine adenosyltransferase I, alpha	170					methylation|S-adenosylmethionine biosynthetic process|xenobiotic metabolic process	cytosol	ATP binding|metal ion binding|methionine adenosyltransferase activity				0			Colorectal(32;0.229)		L-Methionine(DB00134)|S-Adenosylmethionine(DB00118)	GAGGAGGCCGGAGCGCCTGAG	0.577		NA											48	29					0	0	0	0
GRID1	2894	broad.mit.edu	37	10	87614373	87614373	+	Splice_Site	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr10:87614373C>A	uc001kdl.1	-	8	1215	c.1114_splice	c.e8-1	p.G372_splice	GRID1_uc009xsu.1_Splice_Site	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1							cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)	TGATGTGGCCCTGCAGAAGAG	0.498		NA								Multiple Myeloma(13;0.14)			23	9					5.35e-11	6.91e-11	1	0
OPALIN	93377	broad.mit.edu	37	10	98105775	98105775	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr10:98105775C>T	uc001kmj.2	-	6	788	c.349G>A	c.(349-351)GAC>AAC	p.D117N	OPALIN_uc010qor.1_Missense_Mutation_p.D107N|OPALIN_uc001kmi.2_Missense_Mutation_p.D107N|OPALIN_uc001kmk.2_Missense_Mutation_p.D94N|OPALIN_uc010qos.1_RNA	NM_033207	NP_149984	Q96PE5	OPALI_HUMAN	transmembrane protein 10 isoform a	117						Golgi apparatus|integral to membrane|plasma membrane					0						CGGTAACGGTCATGCACAGGT	0.507		NA											59	41					0	0	0	0
GBF1	8729	broad.mit.edu	37	10	104120033	104120033	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr10:104120033G>A	uc001kux.1	+	12	1510	c.1270G>A	c.(1270-1272)GAG>AAG	p.E424K	GBF1_uc001kuw.2_3'UTR|GBF1_uc001kuy.1_Missense_Mutation_p.E424K|GBF1_uc001kuz.1_Missense_Mutation_p.E425K	NM_004193	NP_004184	Q92538	GBF1_HUMAN	golgi-specific brefeldin A resistant guanine	424					COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|regulation of ARF protein signal transduction|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.0236)		Epithelial(162;5.16e-08)|all cancers(201;1.19e-06)		CCATAACTCAGAGGTTATGAT	0.562		NA											183	89					0	0	0	0
TRIM8	81603	broad.mit.edu	37	10	104416663	104416663	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr10:104416663C>T	uc001kvz.2	+	6	1331	c.1208C>T	c.(1207-1209)GCG>GTG	p.A403V		NM_030912	NP_112174	Q9BZR9	TRIM8_HUMAN	tripartite motif-containing 8	403						cytoplasm|PML body	ligase activity|protein homodimerization activity|zinc ion binding			ovary(1)	1		Colorectal(252;0.122)		Epithelial(162;3.93e-09)|all cancers(201;1.02e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		TACGGGGCGGCGGGCACAGCC	0.711		NA											38	23					0	0	0	0
GFRA1	2674	broad.mit.edu	37	10	117885028	117885028	+	Silent	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr10:117885028C>T	uc001lcj.2	-	6	1172	c.474G>A	c.(472-474)GCG>GCA	p.A158A	GFRA1_uc001lci.2_Silent_p.A153A|GFRA1_uc009xyr.2_Silent_p.A153A	NM_005264	NP_005255	P56159	GFRA1_HUMAN	GDNF family receptor alpha 1 isoform a	158	2				axon guidance	anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity			ovary(1)|pancreas(1)	2		Lung NSC(174;0.21)		all cancers(201;0.0337)		TGCAGGCCTTCGCTGCATCCA	0.557		NA											4	14					0	0	0	0
IRF7	3665	broad.mit.edu	37	11	613308	613308	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:613308C>T	uc001lqh.2	-	9	1505	c.1135G>A	c.(1135-1137)GAG>AAG	p.E379K	IRF7_uc009ycb.2_Missense_Mutation_p.E273K|IRF7_uc010qwf.1_Missense_Mutation_p.E378K|IRF7_uc001lqf.2_Missense_Mutation_p.E86K|IRF7_uc010qwg.1_Missense_Mutation_p.E86K|IRF7_uc001lqg.2_Missense_Mutation_p.E392K|IRF7_uc001lqi.2_Missense_Mutation_p.E350K|IRF7_uc010qwh.1_Missense_Mutation_p.E86K	NM_001572	NP_001563	Q92985	IRF7_HUMAN	interferon regulatory factor 7 isoform a	379					interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of interferon-alpha production|positive regulation of transcription from RNA polymerase II promoter|response to virus|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytosol|endosome membrane|nucleoplasm|plasma membrane	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(49;1.69e-08)|all_epithelial(84;1.65e-05)|Breast(177;0.000231)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;7.68e-28)|Epithelial(43;7.44e-27)|OV - Ovarian serous cystadenocarcinoma(40;3.53e-21)|BRCA - Breast invasive adenocarcinoma(625;6.96e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CCGCCCACCTCCCAGTACACC	0.677		NA											13	32					0	0	0	0
MRGPRE	116534	broad.mit.edu	37	11	3249862	3249862	+	Silent	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:3249862G>A	uc001lxq.3	-	2	475	c.165C>T	c.(163-165)AAC>AAT	p.N55N		NM_001039165	NP_001034254	Q86SM8	MRGRE_HUMAN	MAS-related GPR, member E	55	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			large_intestine(1)|ovary(1)	2		Medulloblastoma(188;0.00106)|all_epithelial(84;0.00111)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00529)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGGCGAAGGGGTTTCTGTAGA	0.632		NA											41	65					0	0	0	0
OR52K2	119774	broad.mit.edu	37	11	4470788	4470788	+	Silent	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:4470788G>T	uc001lyz.1	+	1	219	c.219G>T	c.(217-219)CTG>CTT	p.L73L		NM_001005172	NP_001005172	Q8NGK3	O52K2_HUMAN	olfactory receptor, family 52, subfamily K,	73	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;1.48e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0821)|LUSC - Lung squamous cell carcinoma(625;0.19)		CCATCGACCTGGTCCTTTCCT	0.527		NA											74	107					4.12e-46	6.41e-46	1	0
OR52A5	390054	broad.mit.edu	37	11	5153170	5153170	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:5153170C>T	uc010qyx.1	-	1	703	c.703G>A	c.(703-705)GAG>AAG	p.E235K		NM_001005160	NP_001005160	Q9H2C5	O52A5_HUMAN	olfactory receptor, family 52, subfamily A,	235	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|lung(1)|central_nervous_system(1)	4		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		AATCGTGCCTCCTTCTGGGGC	0.418		NA											48	47					0	0	0	0
OR51B6	390058	broad.mit.edu	37	11	5373014	5373014	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:5373014G>T	uc010qzb.1	+	1	277	c.277G>T	c.(277-279)GGA>TGA	p.G93*	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004750	NP_001004750	Q9H340	O51B6_HUMAN	olfactory receptor, family 51, subfamily B,	93	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GATTGGCCATGGAGCCTGCTT	0.483		NA											52	62					7.07e-37	1.09e-36	1	0
OR52D1	390066	broad.mit.edu	37	11	5510563	5510563	+	Silent	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:5510563C>A	uc010qzg.1	+	1	627	c.627C>A	c.(625-627)GCC>GCA	p.A209A	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001005163	NP_001005163	Q9H346	O52D1_HUMAN	olfactory receptor, family 52, subfamily D,	209	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.46e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTCTGCTGGCCATGGGACTGG	0.483		NA											93	167					1.1e-24	1.65e-24	1	0
OR10A4	283297	broad.mit.edu	37	11	6898646	6898647	+	Missense_Mutation	DNP	CA	CA	AT			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:6898646_6898647CA>AT	uc010rat.1	+	1	768_769	c.768_769CA>AT	c.(766-771)GCCATC>GCATTC	p.I257F		NM_207186	NP_997069	Q9H209	O10A4_HUMAN	olfactory receptor, family 10, subfamily A,	257	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		ATAGCACTGCCATCCTCACGTA	0.525		NA											53	71					0	0	0	0
RIC3	79608	broad.mit.edu	37	11	8132424	8132424	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:8132424C>T	uc001mgd.2	-	6	985	c.931G>A	c.(931-933)GAG>AAG	p.E311K	RIC3_uc001mgb.2_Missense_Mutation_p.E149K|RIC3_uc001mgc.2_Missense_Mutation_p.E310K|RIC3_uc001mge.2_Missense_Mutation_p.E129K|RIC3_uc010rbl.1_Missense_Mutation_p.E261K|RIC3_uc010rbm.1_Missense_Mutation_p.E339K|RIC3_uc009yfm.2_Missense_Mutation_p.E230K|RIC3_uc009yfn.2_Missense_Mutation_p.E114K	NM_024557	NP_078833	Q7Z5B4	RIC3_HUMAN	resistance to inhibitors of cholinesterase 3	311	Cytoplasmic (Potential).					endoplasmic reticulum membrane|Golgi membrane|integral to membrane				large_intestine(1)|ovary(1)|pancreas(1)	3				Epithelial(150;2.89e-07)|BRCA - Breast invasive adenocarcinoma(625;0.204)		GCAGGATCCTCGTCTTCATGA	0.483		NA											80	94					0	0	0	0
C11orf16	56673	broad.mit.edu	37	11	8947492	8947492	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:8947492G>A	uc001mhb.3	-	5	846	c.722C>T	c.(721-723)CCT>CTT	p.P241L	C11orf16_uc001mhc.3_Missense_Mutation_p.P241L	NM_020643	NP_065694	Q9NQ32	CK016_HUMAN	hypothetical protein LOC56673	241										upper_aerodigestive_tract(1)|pancreas(1)	2				Epithelial(150;4.11e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0234)		AGAGCAGCAAGGGGCCCAGTG	0.612		NA											14	91					0	0	0	0
PRMT3	10196	broad.mit.edu	37	11	20483570	20483570	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:20483570G>A	uc001mqb.2	+	12	1334	c.1117G>A	c.(1117-1119)GTG>ATG	p.V373M	PRMT3_uc001mqc.2_Missense_Mutation_p.V296M|PRMT3_uc010rdn.1_Missense_Mutation_p.V311M	NM_005788	NP_005779	O60678	ANM3_HUMAN	protein arginine methyltransferase 3 isoform 1	373							zinc ion binding				0						AGTGAGTGATGTGAATAAACA	0.388		NA											43	91					0	0	0	0
ANO5	203859	broad.mit.edu	37	11	22242683	22242683	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:22242683G>T	uc001mqi.2	+	5	538	c.221G>T	c.(220-222)CGA>CTA	p.R74L	ANO5_uc001mqj.2_Missense_Mutation_p.R73L	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	anoctamin 5 isoform a	74	Cytoplasmic (Potential).					chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4						ATCTTCTTCCGAGATGGGATT	0.353		NA											23	32					1.18e-12	1.57e-12	1	0
IMMP1L	196294	broad.mit.edu	37	11	31484808	31484808	+	Silent	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:31484808G>A	uc001msy.1	-	3	212	c.16C>T	c.(16-18)CTG>TTG	p.L6L	IMMP1L_uc001msz.1_Silent_p.L6L|IMMP1L_uc009yjo.2_Silent_p.L6L|IMMP1L_uc009yjp.2_Intron	NM_144981	NP_659418	Q96LU5	IMP1L_HUMAN	IMP1 inner mitochondrial membrane	6					proteolysis	mitochondrial inner membrane	serine-type peptidase activity				0	Lung SC(675;0.225)					GTTTTCCCCAGAACACCACGA	0.363		NA											6	79					0	0	0	0
ALX4	60529	broad.mit.edu	37	11	44286554	44286554	+	Silent	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:44286554C>T	uc001myb.2	-	4	1190	c.1086G>A	c.(1084-1086)ACG>ACA	p.T362T		NM_021926	NP_068745	Q9H161	ALX4_HUMAN	aristaless-like homeobox 4	362					hair follicle development						0						TGCCCATGTGCGTCTGGCCCA	0.677		NA											12	41					0	0	0	0
ZNF408	79797	broad.mit.edu	37	11	46726538	46726538	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:46726538G>C	uc001nde.1	+	5	1518	c.1288G>C	c.(1288-1290)GTA>CTA	p.V430L	ZNF408_uc010rgw.1_Missense_Mutation_p.V422L	NM_024741	NP_079017	Q9H9D4	ZN408_HUMAN	zinc finger protein 408	430	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|identical protein binding|zinc ion binding				0						GCACCAGGTGGTACATTCAGG	0.647		NA											26	66					0	0	0	0
C1QTNF4	114900	broad.mit.edu	37	11	47611622	47611622	+	Silent	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:47611622C>T	uc001ngc.2	-	2	1008	c.741G>A	c.(739-741)CTG>CTA	p.L247L		NM_031909	NP_114115	Q9BXJ3	C1QT4_HUMAN	C1q and tumor necrosis factor related protein 4	247	C1q 2.					extracellular region					0						GGTTCTTCATCAGCTTAACCG	0.677		NA											11	20					0	0	0	0
OR4S1	256148	broad.mit.edu	37	11	48327915	48327915	+	Silent	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:48327915C>A	uc010rhu.1	+	1	141	c.141C>A	c.(139-141)ATC>ATA	p.I47I		NM_001004725	NP_001004725	Q8NGB4	OR4S1_HUMAN	olfactory receptor, family 4, subfamily S,	47	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TCATCACCATCAATGCTAGAA	0.448		NA											69	88					6.13e-21	8.9e-21	1	0
OR4P4	81300	broad.mit.edu	37	11	55405873	55405873	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:55405873G>A	uc010rij.1	+	1	40	c.40G>A	c.(40-42)GGG>AGG	p.G14R		NM_001004124	NP_001004124	Q8NGL7	OR4P4_HUMAN	olfactory receptor, family 4, subfamily P,	14	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						TATTCTCTTGGGGTTTTCCCA	0.313		NA											75	112					0	0	0	0
SPRYD5	84767	broad.mit.edu	37	11	55658943	55658943	+	Silent	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:55658943G>T	uc010rip.1	+	7	1286	c.1194G>T	c.(1192-1194)GTG>GTT	p.V398V	SPRYD5_uc010riq.1_Silent_p.V255V	NM_032681	NP_116070	Q9BSJ1	SPRY5_HUMAN	SPRY domain containing 5	398	B30.2/SPRY.					intracellular	zinc ion binding				0		all_epithelial(135;0.226)				CCCCACTTGTGGTGCAATATG	0.448		NA											24	41					7.26e-15	9.92e-15	1	0
OR5W2	390148	broad.mit.edu	37	11	55681386	55681386	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:55681386C>T	uc010rir.1	-	1	673	c.673G>A	c.(673-675)GTC>ATC	p.V225I		NM_001001960	NP_001001960	Q8NH69	OR5W2_HUMAN	olfactory receptor, family 5, subfamily W,	225	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						ATCTCCAAGACTGATAGGATG	0.403		NA											20	45					0	0	0	0
OR5J2	282775	broad.mit.edu	37	11	55944656	55944656	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:55944656C>A	uc010rjb.1	+	1	563	c.563C>A	c.(562-564)TCA>TAA	p.S188*		NM_001005492	NP_001005492	Q8NH18	OR5J2_HUMAN	olfactory receptor, family 5, subfamily J,	188	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|large_intestine(1)|breast(1)|pancreas(1)	4	Esophageal squamous(21;0.00693)					CTAAAGCTGTCATGTTCTGAC	0.438		NA											47	77					2.13e-23	3.17e-23	1	0
OR8J1	219477	broad.mit.edu	37	11	56128446	56128446	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:56128446G>A	uc010rjh.1	+	1	724	c.724G>A	c.(724-726)GCT>ACT	p.A242T		NM_001005205	NP_001005205	Q8NGP2	OR8J1_HUMAN	olfactory receptor, family 8, subfamily J,	242	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					TTCTACCTGTGCTTCACATAT	0.348		NA											49	79					0	0	0	0
SERPING1	710	broad.mit.edu	37	11	57379390	57379390	+	Silent	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:57379390C>A	uc001nkp.1	+	7	1421	c.1230C>A	c.(1228-1230)CTC>CTA	p.L410L	SERPING1_uc001nkq.1_Silent_p.L373L|SERPING1_uc010rju.1_Silent_p.L358L|SERPING1_uc010rjv.1_Silent_p.L415L|SERPING1_uc001nkr.1_Silent_p.L410L|SERPING1_uc009ymi.1_Silent_p.L419L|SERPING1_uc009ymj.1_Intron|SERPING1_uc001nks.1_Silent_p.L101L	NM_000062	NP_000053	P05155	IC1_HUMAN	serpin peptidase inhibitor, clade G, member 1	410					blood circulation|blood coagulation, intrinsic pathway|complement activation, classical pathway|innate immune response|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation	extracellular space|platelet alpha granule lumen	protein binding|serine-type endopeptidase inhibitor activity			central_nervous_system(1)	1						AGGATATGCTCTCAATCATGG	0.453		NA							Hereditary_Angioedema				28	49					3.7e-05	4.17e-05	1	0
OR5B17	219965	broad.mit.edu	37	11	58126398	58126398	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:58126398G>C	uc010rke.1	-	1	145	c.145C>G	c.(145-147)CTG>GTG	p.L49V		NM_001005489	NP_001005489	Q8NGF7	OR5BH_HUMAN	olfactory receptor, family 5, subfamily B,	49	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				TGAGAGTCCAGCAGGATTAAT	0.463		NA											40	71					0	0	0	0
TCN1	6947	broad.mit.edu	37	11	59626621	59626621	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:59626621C>G	uc001noj.2	-	5	774	c.676G>C	c.(676-678)GAA>CAA	p.E226Q		NM_001062	NP_001053	P20061	TCO1_HUMAN	transcobalamin I precursor	226					cobalamin metabolic process|cobalamin transport|cobalt ion transport	extracellular region	cobalamin binding			ovary(2)	2		all_epithelial(135;0.198)			Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	AGAATCTTTTCTACCAGTGAC	0.413		NA											56	105					0	0	0	0
ZP1	22917	broad.mit.edu	37	11	60637115	60637115	+	Silent	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:60637115C>A	uc001nqd.2	+	3	444	c.424C>A	c.(424-426)CGG>AGG	p.R142R	ZP1_uc001nqe.2_5'Flank	NM_207341	NP_997224	P60852	ZP1_HUMAN	zona pellucida glycoprotein 1 precursor	142	Extracellular (Potential).				single fertilization	integral to membrane|plasma membrane|proteinaceous extracellular matrix					0						TGACCCCTCCCGGACTCTGGA	0.597		NA											20	27					3.08e-08	3.78e-08	1	0
DDB1	1642	broad.mit.edu	37	11	61094321	61094321	+	Silent	SNP	T	T	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:61094321T>A	uc001nrc.3	-	5	820	c.594A>T	c.(592-594)CGA>CGT	p.R198R	DDB1_uc010rle.1_Intron|DDB1_uc010rlf.1_Silent_p.R198R|DDB1_uc010rlg.1_RNA|DDB1_uc001nrd.2_Silent_p.R198R|DDB1_uc009ynl.1_Silent_p.R85R	NM_001923	NP_001914	Q16531	DDB1_HUMAN	damage-specific DNA binding protein 1	198	Interaction with CDT1.				cell cycle checkpoint|interspecies interaction between organisms|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|cytoplasm|nucleoplasm	damaged DNA binding|protein binding			ovary(2)|lung(1)|central_nervous_system(1)	4						ATTCCTTTTCTCGGAGAGACA	0.522		NA						NER					97	158					0	0	0	0
AHNAK	79026	broad.mit.edu	37	11	62296993	62296993	+	Silent	SNP	T	T	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:62296993T>C	uc001ntl.2	-	5	5196	c.4896A>G	c.(4894-4896)CCA>CCG	p.P1632P	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	1632					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				ACTTCCCTTCTGGACCTTCAA	0.473		NA											99	142					0	0	0	0
NRXN2	9379	broad.mit.edu	37	11	64415749	64415749	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:64415749C>A	uc001oar.2	-	18	3784	c.3345G>T	c.(3343-3345)TGG>TGT	p.W1115C	NRXN2_uc001oas.2_Missense_Mutation_p.W1075C|NRXN2_uc001oaq.2_Missense_Mutation_p.W782C	NM_015080	NP_055895	P58401	NRX2B_HUMAN	neurexin 2 isoform alpha-1 precursor	Error:Variant_position_missing_in_P58401_after_alignment					cell adhesion	integral to membrane				upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)|ovary(2)|kidney(1)|pancreas(1)	10						TGAAGCCATCCCACTGCTGCA	0.627		NA											34	62					1.63e-12	2.16e-12	1	0
ANKRD13D	338692	broad.mit.edu	37	11	67068516	67068516	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:67068516G>T	uc001okc.1	+	12	1379	c.868G>T	c.(868-870)GTG>TTG	p.V290L	ANKRD13D_uc001okd.1_Missense_Mutation_p.V377L|ANKRD13D_uc001oke.1_Missense_Mutation_p.V290L|ANKRD13D_uc001okg.1_Missense_Mutation_p.V73L|ANKRD13D_uc001okh.1_Missense_Mutation_p.V73L|ANKRD13D_uc001oki.1_Missense_Mutation_p.V27L|SSH3_uc001okj.2_5'Flank|SSH3_uc001okk.2_5'Flank|SSH3_uc001okl.2_5'Flank	NM_207354	NP_997237	Q6ZTN6	AN13D_HUMAN	ankyrin repeat domain 13 family, member D	290										ovary(1)	1			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			GGGTGACCAGGTGACCCCCAT	0.607		NA											16	29					3.53e-06	4.11e-06	1	0
TBX10	347853	broad.mit.edu	37	11	67399229	67399229	+	Silent	SNP	C	C	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:67399229C>G	uc001omp.2	-	8	1093	c.1005G>C	c.(1003-1005)CCG>CCC	p.P335P	NUDT8_uc001omn.2_5'Flank|NUDT8_uc001omo.1_5'Flank	NM_005995	NP_005986	O75333	TBX10_HUMAN	T-box 10	335					anatomical structure morphogenesis|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						CTAGGTGGCTCGGGGCTCCAG	0.652		NA											7	12					0	0	0	0
LRP5	4041	broad.mit.edu	37	11	68181317	68181317	+	Silent	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:68181317C>T	uc001ont.2	+	12	2739	c.2664C>T	c.(2662-2664)TTC>TTT	p.F888F	LRP5_uc009ysg.2_Silent_p.F298F	NM_002335	NP_002326	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein	888	Beta-propeller 3.|LDL-receptor class B 15.|Extracellular (Potential).				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			lung(2)|skin(2)|ovary(1)|pancreas(1)|breast(1)	7						ACCTGGACTTCGTGATGGACA	0.592		NA											27	33					0	0	0	0
SHANK2	22941	broad.mit.edu	37	11	70332941	70332941	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:70332941G>T	uc001oqc.2	-	21	3535	c.3457C>A	c.(3457-3459)CCC>ACC	p.P1153T	SHANK2_uc010rqn.1_Missense_Mutation_p.P565T|SHANK2_uc001opz.2_Missense_Mutation_p.P558T|uc009ysn.1_Intron|SHANK2_uc001opy.2_Intron	NM_012309	NP_036441	Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	774					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			TGGTTTTCGGGCTCCCTGGGC	0.677		NA											34	49					2.2e-25	3.31e-25	1	0
KRTAP5-9	3846	broad.mit.edu	37	11	71260116	71260116	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:71260116C>T	uc001oqs.1	+	1	651	c.413C>T	c.(412-414)TCA>TTA	p.S138L		NM_005553	NP_005544	P26371	KRA59_HUMAN	keratin associated protein 5-9	138	8 X 4 AA repeats of C-C-X-P.				epidermis development	keratin filament					0						TGCTCATCCTCAGGCTGTGGG	0.612		NA											93	163					0	0	0	0
P4HA3	283208	broad.mit.edu	37	11	74013546	74013546	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:74013546G>T	uc001ouz.2	-	3	478	c.435C>A	c.(433-435)GAC>GAA	p.D145E	P4HA3_uc001ouy.3_RNA|P4HA3_uc010rrj.1_Missense_Mutation_p.D145E	NM_182904	NP_878907	Q7Z4N8	P4HA3_HUMAN	prolyl 4-hydroxylase, alpha III subunit	145						endoplasmic reticulum lumen	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 4-dioxygenase activity			skin(1)	1	Breast(11;2.31e-05)					GCATGTACACGTCCTGCAGCC	0.552		NA											56	109					5.82e-30	8.85e-30	1	0
CHRDL2	25884	broad.mit.edu	37	11	74408263	74408263	+	Silent	SNP	A	A	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:74408263A>G	uc001ovi.2	-	10	1453	c.1200T>C	c.(1198-1200)GCT>GCC	p.A400A	CHRDL2_uc001ovg.2_Silent_p.A284A|CHRDL2_uc001ovh.2_Missense_Mutation_p.W419R			Q6WN34	CRDL2_HUMAN	RecName: Full=Chordin-like protein 2; AltName: Full=Chordin-related protein 2; AltName: Full=Breast tumor novel factor 1;          Short=BNF-1; Flags: Precursor;	400					cartilage development|cell differentiation|ossification	extracellular region|mitochondrion					0	Hepatocellular(1;0.098)					CGTGGGGGCCAGCGAGCAGTC	0.587		NA											40	68					0	0	0	0
OR2AT4	341152	broad.mit.edu	37	11	74800700	74800700	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:74800700C>T	uc010rro.1	-	1	59	c.59G>A	c.(58-60)GGC>GAC	p.G20D		NM_001005285	NP_001005285	A6NND4	O2AT4_HUMAN	olfactory receptor, family 2, subfamily AT,	20	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						AGAGGGGATGCCCAATAGATA	0.507		NA											28	39					0	0	0	0
MMP12	4321	broad.mit.edu	37	11	102738033	102738033	+	Silent	SNP	G	G	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:102738033G>C	uc001phk.2	-	7	924	c.879C>G	c.(877-879)ACC>ACG	p.T293T		NM_002426	NP_002417	P39900	MMP12_HUMAN	matrix metalloproteinase 12 preproprotein	293	Hemopexin-like 1.				positive regulation of epithelial cell proliferation involved in wound healing|proteolysis|wound healing, spreading of epidermal cells	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding				0		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.014)	Acetohydroxamic Acid(DB00551)	TATTTCCCACGGTAGTGACAG	0.368		NA											7	3					0	0	0	0
PIH1D2	120379	broad.mit.edu	37	11	111938637	111938637	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:111938637G>C	uc001pmq.3	-	6	988	c.906C>G	c.(904-906)ATC>ATG	p.I302M	PIH1D2_uc009yyl.2_Intron|PIH1D2_uc001pmp.3_Missense_Mutation_p.I302M	NM_138789	NP_620144	Q8WWB5	PIHD2_HUMAN	PIH1 domain containing 2 isoform 1	302										ovary(1)	1		all_cancers(61;1.09e-14)|all_epithelial(67;7.64e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;3.19e-07)|BRCA - Breast invasive adenocarcinoma(274;6.17e-07)|all cancers(92;6.18e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0508)		ATTTTTCTTTGATAAATTTTG	0.333		NA											38	33					0	0	0	0
FAM55A	120400	broad.mit.edu	37	11	114393726	114393726	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:114393726G>A	uc001ppa.2	-	5	974	c.557C>T	c.(556-558)ACA>ATA	p.T186I	FAM55A_uc010rxd.1_Missense_Mutation_p.T35I	NM_152315	NP_689528	Q8N323	FA55A_HUMAN	hypothetical protein LOC120400	328						extracellular region					0		all_cancers(61;8.53e-16)|all_epithelial(67;1.71e-08)|all_hematologic(158;3.05e-05)|Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0194)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0906)		BRCA - Breast invasive adenocarcinoma(274;3.02e-06)|Epithelial(105;0.000144)|all cancers(92;0.00106)		GTTGCAAAATGTTGTTATCCA	0.403		NA											19	12					0	0	0	0
FAM55D	54827	broad.mit.edu	37	11	114453199	114453199	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:114453199T>G	uc001ppc.2	-	3	822	c.641A>C	c.(640-642)CAA>CCA	p.Q214P	FAM55D_uc001ppd.2_Intron	NM_001077639	NP_001071107	Q6UWF7	FA55D_HUMAN	hypothetical protein LOC54827 isoform 1	214						extracellular region				ovary(2)|skin(2)	4		all_cancers(61;8.53e-16)|all_epithelial(67;1.71e-08)|all_hematologic(158;3.05e-05)|Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0194)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0906)		BRCA - Breast invasive adenocarcinoma(274;2.82e-06)|Epithelial(105;0.000129)|all cancers(92;0.000938)		AGAGTGGACTTGGGAAGTGCC	0.512		NA											36	28					0	0	0	0
DSCAML1	57453	broad.mit.edu	37	11	117299175	117299175	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:117299175G>A	uc001prh.1	-	33	6213	c.6211C>T	c.(6211-6213)CCA>TCA	p.P2071S		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	2011	Cytoplasmic (Potential).|Pro-rich.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		CCGGCTCGTGGAGGCTCGGTG	0.746		NA											7	6					0	0	0	0
USP2	9099	broad.mit.edu	37	11	119229766	119229766	+	Silent	SNP	A	A	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:119229766A>T	uc001pwm.3	-	6	1435	c.1140T>A	c.(1138-1140)CCT>CCA	p.P380P	USP2_uc001pwl.3_Silent_p.P171P|USP2_uc001pwn.3_Silent_p.P137P	NM_004205	NP_004196	O75604	UBP2_HUMAN	ubiquitin specific peptidase 2 isoform a	380					cell cycle|muscle organ development|negative regulation of transcription from RNA polymerase II promoter|positive regulation of mitotic cell cycle|protein deubiquitination|protein stabilization|ubiquitin-dependent protein catabolic process	nucleus|perinuclear region of cytoplasm	cyclin binding|cysteine-type endopeptidase activity|metal ion binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity			ovary(2)|urinary_tract(1)|skin(1)	4		all_hematologic(192;4.65e-05)|Breast(348;0.0101)|all_neural(223;0.0218)|Medulloblastoma(222;0.0425)|Renal(330;0.157)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.000513)|Colorectal(284;0.0116)|Lung(307;0.0853)|LUSC - Lung squamous cell carcinoma(976;0.0889)		GGTTGGACTTAGGTCTCAGTG	0.483		NA											39	15					0	0	0	0
OPCML	4978	broad.mit.edu	37	11	132306621	132306621	+	Silent	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:132306621C>T	uc001qgs.2	-	5	767	c.717G>A	c.(715-717)AAG>AAA	p.K239K	OPCML_uc001qgu.2_Silent_p.K232K|OPCML_uc010sck.1_Silent_p.K239K|OPCML_uc001qgt.2_Silent_p.K238K|OPCML_uc010scl.1_Silent_p.K198K	NM_002545	NP_002536	Q14982	OPCM_HUMAN	opioid binding protein/cell adhesion	239	Ig-like C2-type 3.				cell adhesion|neuron recognition	anchored to membrane|integral to plasma membrane	opioid receptor activity			ovary(2)|skin(1)	3	all_hematologic(175;0.019)	all_cancers(12;5.86e-24)|all_epithelial(12;2.65e-17)|all_lung(97;2.89e-05)|Lung NSC(97;6.16e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0269)|all_neural(223;0.0326)|Esophageal squamous(93;0.129)		all cancers(11;4.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.012)		TCAGGATGCCCTTCTGACCGA	0.393		NA											21	21					0	0	0	0
IGSF9B	22997	broad.mit.edu	37	11	133790844	133790844	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:133790844G>T	uc001qgx.3	-	18	3007	c.2776C>A	c.(2776-2778)CCA>ACA	p.P926T		NM_014987	NP_055802	Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	926	Pro-rich.|Cytoplasmic (Potential).					integral to membrane|plasma membrane					0	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		CTGTATGCTGGTGGTGGCAGG	0.706		NA											32	21					2.81e-11	3.65e-11	1	0
IQSEC3	440073	broad.mit.edu	37	12	266858	266858	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:266858G>A	uc001qhw.1	+	4	1538	c.1532G>A	c.(1531-1533)CGA>CAA	p.R511Q	IQSEC3_uc001qhu.1_Missense_Mutation_p.R511Q	NM_015232	NP_056047	Q9UPP2	IQEC3_HUMAN	IQ motif and Sec7 domain 3	814	SEC7.				regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|large_intestine(1)|skin(1)	4	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)		CGAAACCTTCGAGGTGAGGAG	0.587		NA											5	57					0	0	0	0
AKAP3	10566	broad.mit.edu	37	12	4747326	4747326	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:4747326C>T	uc001qnb.3	-	3	266	c.37G>A	c.(37-39)GGA>AGA	p.G13R		NM_006422	NP_006413	O75969	AKAP3_HUMAN	A-kinase anchor protein 3	13					acrosome reaction|cellular component movement	acrosomal vesicle	protein kinase A binding			skin(3)|large_intestine(1)|ovary(1)|kidney(1)	6						TTGCATACTCCATTTTGGCTT	0.408		NA											44	149					0	0	0	0
GAPDH	2597	broad.mit.edu	37	12	6646845	6646845	+	Silent	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:6646845C>A	uc001qop.1	+	8	723	c.621C>A	c.(619-621)ATC>ATA	p.I207I	GAPDH_uc009zep.1_Silent_p.I165I|GAPDH_uc001qoq.1_Silent_p.I132I|GAPDH_uc001qor.1_Silent_p.I166I|GAPDH_uc001qos.1_Silent_p.I207I|GAPDH_uc001qot.1_Silent_p.I207I|GAPDH_uc001qou.1_Silent_p.I166I|GAPDH_uc001qov.1_Silent_p.I165I|GAPDH_uc001qow.1_Silent_p.I160I|GAPDH_uc001qox.1_Silent_p.I33I	NM_002046	NP_002037	P04406	G3P_HUMAN	glyceraldehyde-3-phosphate dehydrogenase	207					gluconeogenesis|glycolysis|neuron apoptosis|peptidyl-cysteine S-trans-nitrosylation|protein stabilization	cytosol|membrane|nucleus|perinuclear region of cytoplasm	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity|NAD binding|peptidyl-cysteine S-nitrosylase activity|protein binding				0					NADH(DB00157)	AGAACATCATCCCTGCCTCTA	0.622		NA									OREG0021628	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	16					0.000308642	0.000338576	1	0
C1R	715	broad.mit.edu	37	12	7188341	7188341	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:7188341C>A	uc010sfy.1	-	10	1672	c.1613G>T	c.(1612-1614)CGC>CTC	p.R538L		NM_001733	NP_001724	P00736	C1R_HUMAN	complement component 1, r subcomponent	538	Peptidase S1.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity				0					Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	GCTGACCCTGCGGATGGGGTG	0.552		NA											30	98					2.46e-21	3.58e-21	1	0
BCL2L14	79370	broad.mit.edu	37	12	12232294	12232294	+	Silent	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:12232294C>T	uc001rac.2	+	2	256	c.55C>T	c.(55-57)CTA>TTA	p.L19L	ETV6_uc001raa.1_Intron|BCL2L14_uc001raf.1_RNA|BCL2L14_uc001rad.2_Silent_p.L19L|BCL2L14_uc001rae.2_Silent_p.L19L	NM_138723	NP_620049	Q9BZR8	B2L14_HUMAN	BCL2-like 14 isoform 1	19					apoptosis|regulation of apoptosis	cytosol|endomembrane system|intracellular organelle|membrane	protein binding			skin(1)	1		Prostate(47;0.0872)		BRCA - Breast invasive adenocarcinoma(232;0.154)		TGATGATGACCTAAACACCAT	0.483		NA											13	96					0	0	0	0
LST-3TM12	338821	broad.mit.edu	37	12	21168707	21168707	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:21168707C>A	uc010sin.1	+	1	78	c.78C>A	c.(76-78)TTC>TTA	p.F26L	SLCO1B3_uc010sil.1_Intron|LST-3TM12_uc010sim.1_Intron	NM_001009562	NP_001009562	Q71QF0	Q71QF0_HUMAN	liver-specific organic anion transporter 3TM12	26						membrane	transporter activity				0						ATGGAAGCTTCGAAATAGGTA	0.249		NA											10	15					3.86e-05	4.34e-05	1	0
ADAMTS20	80070	broad.mit.edu	37	12	43769237	43769237	+	Silent	SNP	A	A	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:43769237A>G	uc010skx.1	-	36	5391	c.5391T>C	c.(5389-5391)GCT>GCC	p.A1797A		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	1797	GON.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		CAGTGTATCCAGCAGCTAAGT	0.338		NA											15	57					0	0	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43846439	43846439	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:43846439G>C	uc010skx.1	-	13	1820	c.1820C>G	c.(1819-1821)ACT>AGT	p.T607S		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	607	TSP type-1 1.					proteinaceous extracellular matrix	zinc ion binding	p.T607T(1)		central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		ACATGAATCAGTATTACATGA	0.403		NA											3	20					0	0	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43847820	43847820	+	Silent	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:43847820C>T	uc010skx.1	-	12	1650	c.1650G>A	c.(1648-1650)ACG>ACA	p.T550T		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	550	Disintegrin.					proteinaceous extracellular matrix	zinc ion binding	p.T550M(1)		central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		GACGTGTTTCCGTTTCTTTGT	0.398		NA											4	34					0	0	0	0
ADCY6	112	broad.mit.edu	37	12	49164737	49164737	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:49164737C>A	uc001rsh.3	-	19	3728	c.3068G>T	c.(3067-3069)CGG>CTG	p.R1023L	ADCY6_uc001rsj.3_Missense_Mutation_p.R1023L|ADCY6_uc001rsi.3_Missense_Mutation_p.R970L|ADCY6_uc010slw.1_3'UTR	NM_015270	NP_056085	O43306	ADCY6_HUMAN	adenylate cyclase 6 isoform a	1023	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding				0						CTGCCGGAACCGCTCCTCGCT	0.577		NA											14	24					1.05e-09	1.33e-09	1	0
RHEBL1	121268	broad.mit.edu	37	12	49460759	49460759	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:49460759C>T	uc001rtc.1	-	3	391	c.184G>A	c.(184-186)GCA>ACA	p.A62T	RHEBL1_uc001rtd.1_Missense_Mutation_p.A58T|RHEBL1_uc009zlc.1_Intron	NM_144593	NP_653194	Q8TAI7	REBL1_HUMAN	Ras homolog enriched in brain like 1 precursor	62	GTP (By similarity).				positive regulation of NF-kappaB transcription factor activity|small GTPase mediated signal transduction|TOR signaling cascade	cytoplasm|plasma membrane	GTP binding|GTPase activity|protein binding			lung(1)|breast(1)	2						ACCTGCCCTGCTGTGTCCACC	0.453		NA											5	66					0	0	0	0
LIMA1	51474	broad.mit.edu	37	12	50594642	50594642	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:50594642T>C	uc001rwj.3	-	7	1064	c.890A>G	c.(889-891)GAA>GGA	p.E297G	LIMA1_uc001rwg.3_5'UTR|LIMA1_uc001rwh.3_Missense_Mutation_p.E137G|LIMA1_uc001rwi.3_Missense_Mutation_p.E137G|LIMA1_uc001rwk.3_Missense_Mutation_p.E297G|LIMA1_uc010smr.1_RNA|LIMA1_uc010sms.1_RNA	NM_016357	NP_057441	Q9UHB6	LIMA1_HUMAN	LIM domain and actin binding 1 isoform b	297					actin filament bundle assembly|negative regulation of actin filament depolymerization|ruffle organization	cytoplasm|focal adhesion|stress fiber	actin filament binding|actin monomer binding|zinc ion binding			ovary(1)	1						AATTTTGATTTCGCCACCACT	0.388		NA											110	123					0	0	0	0
SCN8A	6334	broad.mit.edu	37	12	52164414	52164414	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:52164414A>G	uc001ryw.2	+	19	3770	c.3592A>G	c.(3592-3594)AAC>GAC	p.N1198D	SCN8A_uc010snl.1_Missense_Mutation_p.N1063D	NM_014191	NP_055006	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha	1198	III.|Helical; Name=S1 of repeat III; (Potential).				axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			ovary(7)	7				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	CGTGGAGCACAACTGGTTTGA	0.562		NA											7	44					0	0	0	0
RARG	5916	broad.mit.edu	37	12	53621207	53621207	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:53621207C>G	uc001sce.2	-	3	608	c.123G>C	c.(121-123)ATG>ATC	p.M41I	RARG_uc001scf.2_Missense_Mutation_p.M41I|RARG_uc001scg.2_Intron|RARG_uc010soc.1_Intron	NM_000966	NP_000957	P13631	RARG_HUMAN	retinoic acid receptor, gamma isoform 1	41	Modulating.				canonical Wnt receptor signaling pathway|embryonic eye morphogenesis|embryonic hindlimb morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|regulation of cell size|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid	integral to membrane|transcription factor complex	retinoic acid receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(2)|ovary(1)|lung(1)	4					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	TAGGGCTCAGCATCTCGAAAG	0.627		NA											62	29					0	0	0	0
ESPL1	9700	broad.mit.edu	37	12	53684657	53684657	+	Silent	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:53684657G>T	uc001sck.2	+	25	5488	c.5397G>T	c.(5395-5397)CTG>CTT	p.L1799L	ESPL1_uc001scj.2_Silent_p.L1474L	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	1799					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3						AGTCTGTGCTGGGCTGCTGGA	0.592		NA											8	11					1.07e-07	1.29e-07	1	0
SLC16A7	9194	broad.mit.edu	37	12	60168743	60168743	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:60168743A>G	uc001sqs.2	+	5	966	c.667A>G	c.(667-669)ATC>GTC	p.I223V	SLC16A7_uc001sqt.2_Missense_Mutation_p.I223V|SLC16A7_uc001squ.2_Missense_Mutation_p.I223V|SLC16A7_uc009zqi.2_Missense_Mutation_p.I124V|SLC16A7_uc010ssi.1_Missense_Mutation_p.I124V	NM_004731	NP_004722	O60669	MOT2_HUMAN	solute carrier family 16, member 7	223	Cytoplasmic (Potential).					integral to plasma membrane|membrane fraction	pyruvate secondary active transmembrane transporter activity|secondary active monocarboxylate transmembrane transporter activity|symporter activity			ovary(1)	1				GBM - Glioblastoma multiforme(3;0.0303)	Pyruvic acid(DB00119)	CCCAAAGAAAATCAAAACGAA	0.363		NA											15	17					0	0	0	0
RASSF3	283349	broad.mit.edu	37	12	65088583	65088583	+	Missense_Mutation	SNP	G	G	T	rs147804503		TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:65088583G>T	uc001ssd.2	+	5	728	c.608G>T	c.(607-609)CGC>CTC	p.R203L	RASSF3_uc009zqn.2_RNA|RASSF3_uc001sse.2_Missense_Mutation_p.R133L	NM_178169	NP_835463	Q86WH2	RASF3_HUMAN	Ras association (RalGDS/AF-6) domain family	203	SARAH.				signal transduction	cytoplasm|microtubule	identical protein binding				0			Lung(2;0.00133)|LUAD - Lung adenocarcinoma(6;0.0665)|LUSC - Lung squamous cell carcinoma(43;0.132)	GBM - Glioblastoma multiforme(28;0.0611)		AATTTCTTGCGCATCTTGGAC	0.473		NA											39	56					2.27e-22	3.34e-22	1	0
BEST3	144453	broad.mit.edu	37	12	70087573	70087573	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:70087573C>A	uc001svg.2	-	4	589	c.362G>T	c.(361-363)GGG>GTG	p.G121V	BEST3_uc001svd.1_Missense_Mutation_p.G121V|BEST3_uc001sve.1_RNA|BEST3_uc010stm.1_Missense_Mutation_p.G15V|BEST3_uc001svh.2_5'UTR|BEST3_uc001svi.1_RNA	NM_032735	NP_116124	Q8N1M1	BEST3_HUMAN	vitelliform macular dystrophy 2-like 3 isoform	121	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	chloride channel activity				0	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			AAGCAGGCGCCCGTGCTCGTC	0.532		NA											15	30					1.52e-12	2.02e-12	1	0
TRHDE	29953	broad.mit.edu	37	12	72936127	72936127	+	Silent	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:72936127G>A	uc001sxa.2	+	7	1674	c.1644G>A	c.(1642-1644)AGG>AGA	p.R548R		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	548	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						TTTTCCAGAGGGGTTTGCAAG	0.308		NA											16	20					0	0	0	0
NAV3	89795	broad.mit.edu	37	12	78400833	78400833	+	Silent	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:78400833G>A	uc001syp.2	+	8	1688	c.1515G>A	c.(1513-1515)TTG>TTA	p.L505L	NAV3_uc001syo.2_Silent_p.L505L	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	505						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						TTGCAAGCTTGATCCCTAAGG	0.428		NA								HNSCC(70;0.22)			35	29					0	0	0	0
NAV3	89795	broad.mit.edu	37	12	78553062	78553062	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:78553062A>C	uc001syp.2	+	23	5038	c.4865A>C	c.(4864-4866)CAA>CCA	p.Q1622P	NAV3_uc001syo.2_Missense_Mutation_p.Q1622P|NAV3_uc010sub.1_Missense_Mutation_p.Q1108P|NAV3_uc009zsf.2_Missense_Mutation_p.Q453P	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1622	Potential.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						ACAGCGGAACAAAAGGTATGT	0.383		NA								HNSCC(70;0.22)			13	42					0	0	0	0
PPFIA2	8499	broad.mit.edu	37	12	82147793	82147793	+	Silent	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:82147793G>T	uc001szo.1	-	3	369	c.208C>A	c.(208-210)CGA>AGA	p.R70R	PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment										ovary(3)|lung(2)|pancreas(1)	6						AGTGAGTCTCGGTCATAGATG	0.468		NA											6	20					2.01e-06	2.35e-06	1	0
ALX1	8092	broad.mit.edu	37	12	85677506	85677506	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:85677506C>T	uc001tae.3	+	2	387	c.383C>T	c.(382-384)TCC>TTC	p.S128F		NM_006982	NP_008913	Q15699	ALX1_HUMAN	cartilage paired-class homeoprotein 1	128					brain development|cartilage condensation|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(134;0.134)		AGCAATGTATCCAGCAGTAAG	0.478		NA											41	38					0	0	0	0
C12orf50	160419	broad.mit.edu	37	12	88381702	88381702	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:88381702G>A	uc001tam.1	-	9	910	c.742C>T	c.(742-744)CGA>TGA	p.R248*	C12orf50_uc001tan.2_Intron	NM_152589	NP_689802	Q8NA57	CL050_HUMAN	hypothetical protein LOC160419	248										skin(2)|ovary(1)	3						GGTACTAGTCGGGTAGTTAGG	0.343		NA											23	31					0	0	0	0
STAB2	55576	broad.mit.edu	37	12	104152959	104152959	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:104152959T>C	uc001tjw.2	+	65	7342	c.7156T>C	c.(7156-7158)TTT>CTT	p.F2386L	STAB2_uc009zug.2_RNA	NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	2386	Extracellular (Potential).|FAS1 7.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						TGTCAGCATGTTTTTCTACAA	0.507		NA											58	51					0	0	0	0
ACACB	32	broad.mit.edu	37	12	109684049	109684049	+	Silent	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:109684049C>A	uc001tob.2	+	39	5486	c.5367C>A	c.(5365-5367)ATC>ATA	p.I1789I	ACACB_uc001toc.2_Silent_p.I1789I|ACACB_uc010sxl.1_RNA|ACACB_uc001tod.2_RNA|ACACB_uc010sxm.1_Silent_p.I455I	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	1789					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	GGGATGTGATCGTCATCGGCA	0.552		NA											39	33					1.57e-19	2.26e-19	1	0
ATXN2	6311	broad.mit.edu	37	12	111923529	111923529	+	Silent	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:111923529G>A	uc001tsj.2	-	17	3087	c.2925C>T	c.(2923-2925)AGC>AGT	p.S975S	ATXN2_uc001tsh.2_Silent_p.S710S|ATXN2_uc001tsi.2_Silent_p.S686S|ATXN2_uc001tsk.2_RNA|ATXN2_uc001tsg.2_Silent_p.S161S	NM_002973	NP_002964	Q99700	ATX2_HUMAN	ataxin 2	975	Pro-rich.				cell death|cytoplasmic mRNA processing body assembly|regulation of translation|RNA metabolic process|RNA transport|stress granule assembly	nucleus|perinuclear region of cytoplasm|polysome|stress granule|trans-Golgi network	protein C-terminus binding|RNA binding			ovary(1)|breast(1)	2						GCACGCCTGGGCTCACTGGGA	0.453		NA											16	56					0	0	0	0
NOS1	4842	broad.mit.edu	37	12	117685212	117685212	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:117685212C>T	uc001twm.1	-	18	3450	c.2764G>A	c.(2764-2766)GGG>AGG	p.G922R		NM_000620	NP_000611	P29475	NOS1_HUMAN	nitric oxide synthase 1, neuronal	922	Flavodoxin-like.				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			ovary(3)|skin(3)|pancreas(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	AGCTCATCCCCTTCCCTCATC	0.552		NA											54	61					0	0	0	0
CIT	11113	broad.mit.edu	37	12	120173008	120173008	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:120173008C>A	uc001txi.1	-	24	3040	c.2987G>T	c.(2986-2988)CGG>CTG	p.R996L	CIT_uc001txh.1_Missense_Mutation_p.R530L|CIT_uc001txj.1_Missense_Mutation_p.R1038L	NM_007174	NP_009105	O14578	CTRO_HUMAN	citron	996	Potential.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		CGTGATCTCCCGGCGGAGATG	0.498		NA											31	88					4.32e-19	6.17e-19	1	0
PXN	5829	broad.mit.edu	37	12	120652757	120652757	+	Silent	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:120652757G>T	uc001txt.2	-	9	1280	c.1149C>A	c.(1147-1149)GTC>GTA	p.V383V	PXN_uc001txu.2_Silent_p.V195V|PXN_uc001txv.2_Silent_p.V264V|PXN_uc001txx.2_Silent_p.V216V|PXN_uc001txy.2_Silent_p.V349V|PXN_uc001txz.2_RNA	NM_001080855	NP_001074324	P49023	PAXI_HUMAN	paxillin isoform 1	383	LIM zinc-binding 1.				cell junction assembly|cell-matrix adhesion|cellular response to reactive oxygen species|epidermal growth factor receptor signaling pathway|growth hormone receptor signaling pathway|muscle contraction|signal complex assembly	cytoplasm|focal adhesion|lamellipodium|microtubule associated complex	beta-catenin binding|vinculin binding|zinc ion binding			ovary(1)|breast(1)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					AGTGGGTGCAGACGAAGTGCT	0.632		NA											4	23					0.00024832	0.000274217	1	0
PITPNM2	57605	broad.mit.edu	37	12	123485364	123485364	+	Silent	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:123485364G>A	uc001uej.1	-	9	1324	c.1185C>T	c.(1183-1185)TTC>TTT	p.F395F	PITPNM2_uc001uek.1_Silent_p.F395F|PITPNM2_uc009zxu.1_Silent_p.F395F	NM_020845	NP_065896	Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein,	395					metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		AGGCCACCCTGAACTCAGGGG	0.652		NA											4	26					0	0	0	0
GTF2H3	2967	broad.mit.edu	37	12	124144433	124144433	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:124144433G>A	uc001ufo.1	+	11	802	c.776G>A	c.(775-777)CGA>CAA	p.R259Q	GTF2H3_uc010tau.1_Missense_Mutation_p.R218Q	NM_001516	NP_001507	Q13889	TF2H3_HUMAN	general transcription factor IIH, polypeptide 3,	259					mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of viral transcription|protein phosphorylation|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	core TFIIH complex|holo TFIIH complex	damaged DNA binding|metal ion binding|protein N-terminus binding|sequence-specific DNA binding transcription factor activity|translation factor activity, nucleic acid binding				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.1e-05)|Epithelial(86;0.000388)|all cancers(50;0.00362)		TTCTGTCATCGAAATCTCATT	0.413		NA						NER					16	68					0	0	0	0
TCTN2	79867	broad.mit.edu	37	12	124191294	124191294	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:124191294G>T	uc001ufp.2	+	16	1919	c.1791G>T	c.(1789-1791)CAG>CAT	p.Q597H	TCTN2_uc009zya.2_Missense_Mutation_p.Q596H	NM_024809	NP_079085	Q96GX1	TECT2_HUMAN	tectonic family member 2 isoform 1	597	Extracellular (Potential).				cilium assembly|smoothened signaling pathway	integral to membrane				ovary(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000163)|Epithelial(86;0.000502)|all cancers(50;0.00451)		TGAACTGGCAGTACCAGTGTG	0.502		NA											39	61					2.27e-22	3.34e-22	1	0
RIMBP2	23504	broad.mit.edu	37	12	130926460	130926460	+	Silent	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:130926460C>A	uc001uil.2	-	8	1550	c.1386G>T	c.(1384-1386)CCG>CCT	p.P462P	RIMBP2_uc001uim.2_Silent_p.P370P|RIMBP2_uc001uin.1_Silent_p.P121P	NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	462	Fibronectin type-III 2.					cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		GGAGCTGCCACGGCATCTGGT	0.587		NA											22	32					2.4e-15	3.29e-15	1	0
EP400	57634	broad.mit.edu	37	12	132510276	132510276	+	Silent	SNP	G	G	T	rs79827647	by1000genomes	TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:132510276G>T	uc001ujn.2	+	24	4976	c.4941G>T	c.(4939-4941)GCG>GCT	p.A1647A	EP400_uc001ujl.2_Silent_p.A1646A|EP400_uc001ujm.2_Silent_p.A1566A	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	1683					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		TGTCTCAGGCGGGCGCTGTGC	0.692		NA											5	24					1.24e-05	1.41e-05	1	0
CHFR	55743	broad.mit.edu	37	12	133433063	133433063	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr12:133433063G>C	uc001ulf.2	-	10	1340	c.1256C>G	c.(1255-1257)TCA>TGA	p.S419*	CHFR_uc001ulc.1_RNA|CHFR_uc001ule.2_Nonsense_Mutation_p.S407*|CHFR_uc010tbs.1_Nonsense_Mutation_p.S419*|CHFR_uc001uld.2_Nonsense_Mutation_p.S378*|CHFR_uc010tbt.1_Nonsense_Mutation_p.S327*	NM_001161344	NP_001154816	Q96EP1	CHFR_HUMAN	checkpoint with forkhead and ring finger domains	419					cell division|mitosis|mitotic cell cycle checkpoint|modification-dependent protein catabolic process|protein polyubiquitination	PML body	nucleotide binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(1)	1	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;0.00552)|all_epithelial(31;0.226)		OV - Ovarian serous cystadenocarcinoma(86;2.59e-08)|Epithelial(86;6.38e-07)|all cancers(50;1.56e-05)		CCTAATGTCTGAGGACTCACT	0.537		NA											31	108					0	0	0	0
FREM2	341640	broad.mit.edu	37	13	39262131	39262131	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr13:39262131G>T	uc001uwv.2	+	1	959	c.650G>T	c.(649-651)CGC>CTC	p.R217L		NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	217	Extracellular (Potential).				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		GAGGAGTGCCGCGTGGGCATC	0.682		NA											34	11					9.18e-22	1.34e-21	1	0
RB1	5925	broad.mit.edu	37	13	48941688	48941688	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr13:48941688C>T	uc001vcb.2	+	10	1164	c.998C>T	c.(997-999)GCA>GTA	p.A333V	RB1_uc010act.1_Missense_Mutation_p.A34V	NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	333					androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(6)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GATCTAGATGCAAGATTATTT	0.284		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			48	29					0	0	0	0
PCDH17	27253	broad.mit.edu	37	13	58298958	58298958	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr13:58298958G>C	uc001vhq.1	+	4	3902	c.3010G>C	c.(3010-3012)GAC>CAC	p.D1004H	PCDH17_uc010aec.1_Missense_Mutation_p.D1003H|PCDH17_uc001vhr.1_Missense_Mutation_p.D93H	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	1004	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		ATTTGGAAAAGACAAGCGAGA	0.433		NA											55	23					0	0	0	0
PCDH20	64881	broad.mit.edu	37	13	61985813	61985813	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr13:61985813C>T	uc001vid.3	-	2	2783	c.2419G>A	c.(2419-2421)GAA>AAA	p.E807K	PCDH20_uc010thj.1_Missense_Mutation_p.E807K	NM_022843	NP_073754	Q8N6Y1	PCD20_HUMAN	protocadherin 20	780	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|breast(1)|central_nervous_system(1)	6		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		AATGCCTCTTCCAAAGTAATG	0.488		NA											81	30					0	0	0	0
FARP1	10160	broad.mit.edu	37	13	99092244	99092244	+	Silent	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr13:99092244G>T	uc001vnj.2	+	22	2799	c.2463G>T	c.(2461-2463)GTG>GTT	p.V821V	FARP1_uc001vnh.2_Silent_p.V852V	NM_005766	NP_005757	Q9Y4F1	FARP1_HUMAN	FERM, RhoGEF, and pleckstrin domain protein 1	821	PH 1.				regulation of Rho protein signal transduction	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			AGTGGGGGGTGCCCCACTGCC	0.617		NA											157	65					1.46e-73	2.29e-73	1	0
DOCK9	23348	broad.mit.edu	37	13	99481561	99481561	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr13:99481561C>G	uc001vnt.2	-	43	4954	c.4899G>C	c.(4897-4899)GAG>GAC	p.E1633D	DOCK9_uc001vnw.2_Missense_Mutation_p.E1632D|DOCK9_uc001vnv.1_RNA|DOCK9_uc010tir.1_Missense_Mutation_p.E1633D|DOCK9_uc001vnq.2_Missense_Mutation_p.E205D|DOCK9_uc001vnr.2_Missense_Mutation_p.E276D|DOCK9_uc010tin.1_Missense_Mutation_p.E276D|DOCK9_uc001vns.2_Missense_Mutation_p.E205D|DOCK9_uc010tio.1_Missense_Mutation_p.E325D|DOCK9_uc010tip.1_Missense_Mutation_p.E343D|DOCK9_uc001vnu.1_Missense_Mutation_p.E205D|DOCK9_uc010tiq.1_Missense_Mutation_p.E611D	NM_015296	NP_056111	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9 isoform a	1633	DHR-2.				blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					GGGCTACTACCTCTGAGAGAT	0.488		NA											4	2					0	0	0	0
MYO16	23026	broad.mit.edu	37	13	109793638	109793638	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr13:109793638C>A	uc001vqt.1	+	32	5138	c.5012C>A	c.(5011-5013)CCC>CAC	p.P1671H	MYO16_uc010agk.1_Missense_Mutation_p.P1693H	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	1671	Pro-rich.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			CTCAGCAGCCCCCTGGACGAG	0.672		NA											6	4					8.13e-05	9.08e-05	1	0
REM2	161253	broad.mit.edu	37	14	23354038	23354038	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr14:23354038G>C	uc001whf.1	+	2	324	c.259G>C	c.(259-261)GAC>CAC	p.D87H	REM2_uc010tnd.1_Missense_Mutation_p.D79H	NM_173527	NP_775798	Q8IYK8	REM2_HUMAN	rad and gem related GTP binding protein 2	87					regulation of transcription, DNA-dependent|small GTPase mediated signal transduction	intracellular|plasma membrane	ATP binding|GTP binding|transcription factor binding			large_intestine(1)|central_nervous_system(1)	2	all_cancers(95;4.69e-05)			GBM - Glioblastoma multiforme(265;0.012)		AGATGAACTTGACTGGCCACC	0.622		NA											7	81					0	0	0	0
REM2	161253	broad.mit.edu	37	14	23355356	23355356	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr14:23355356G>A	uc001whf.1	+	4	708	c.643G>A	c.(643-645)GCT>ACT	p.A215T	REM2_uc010tnd.1_Missense_Mutation_p.G182D	NM_173527	NP_775798	Q8IYK8	REM2_HUMAN	rad and gem related GTP binding protein 2	215					regulation of transcription, DNA-dependent|small GTPase mediated signal transduction	intracellular|plasma membrane	ATP binding|GTP binding|transcription factor binding			large_intestine(1)|central_nervous_system(1)	2	all_cancers(95;4.69e-05)			GBM - Glioblastoma multiforme(265;0.012)		TCGGCTCCGGGCTGGGAGGCC	0.597		NA											7	61					0	0	0	0
CTSG	1511	broad.mit.edu	37	14	25043923	25043923	+	Silent	SNP	T	T	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr14:25043923T>C	uc001wpq.2	-	3	334	c.297A>G	c.(295-297)CAA>CAG	p.Q99Q		NM_001911	NP_001902	P08311	CATG_HUMAN	cathepsin G preproprotein	99	Peptidase S1.				immune response|proteolysis	cell surface|extracellular space|plasma membrane|stored secretory granule	heparin binding|serine-type endopeptidase activity			ovary(2)	2				GBM - Glioblastoma multiforme(265;0.0269)		GCTGATTATATTGAGGGTGGC	0.537		NA											104	28					0	0	0	0
STRN3	29966	broad.mit.edu	37	14	31405784	31405784	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr14:31405784C>A	uc001wqu.2	-	6	979	c.763G>T	c.(763-765)GAT>TAT	p.D255Y	STRN3_uc001wqv.2_Missense_Mutation_p.D255Y|STRN3_uc010tpj.1_RNA	NM_001083893	NP_001077362	Q13033	STRN3_HUMAN	nuclear autoantigen isoform 1	255					negative regulation of estrogen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|response to estradiol stimulus	cytoplasm|dendrite|Golgi apparatus|neuronal cell body|nucleoplasm|nucleus|plasma membrane|protein complex	armadillo repeat domain binding|calmodulin binding|protein complex binding|protein phosphatase 2A binding|sequence-specific DNA binding transcription factor activity				0	Hepatocellular(127;0.0877)|Breast(36;0.148)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)|BRCA - Breast invasive adenocarcinoma(188;0.0805)	GBM - Glioblastoma multiforme(265;0.0124)		TCACTGTCATCGGCATTTTCT	0.363		NA											58	17					2.37e-18	3.34e-18	1	0
STRN3	29966	broad.mit.edu	37	14	31405799	31405799	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr14:31405799A>C	uc001wqu.2	-	6	964	c.748T>G	c.(748-750)TTC>GTC	p.F250V	STRN3_uc001wqv.2_Missense_Mutation_p.F250V|STRN3_uc010tpj.1_RNA	NM_001083893	NP_001077362	Q13033	STRN3_HUMAN	nuclear autoantigen isoform 1	250					negative regulation of estrogen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|response to estradiol stimulus	cytoplasm|dendrite|Golgi apparatus|neuronal cell body|nucleoplasm|nucleus|plasma membrane|protein complex	armadillo repeat domain binding|calmodulin binding|protein complex binding|protein phosphatase 2A binding|sequence-specific DNA binding transcription factor activity				0	Hepatocellular(127;0.0877)|Breast(36;0.148)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)|BRCA - Breast invasive adenocarcinoma(188;0.0805)	GBM - Glioblastoma multiforme(265;0.0124)		TTTTCTAAGAAATTGAACGTC	0.383		NA											51	17					0	0	0	0
CDKL1	8814	broad.mit.edu	37	14	50857053	50857053	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr14:50857053C>T	uc010anu.1	-	6	856	c.856G>A	c.(856-858)GGT>AGT	p.G286S	CDKL1_uc001wxz.2_Intron	NM_004196	NP_004187	Q00532	CDKL1_HUMAN	cyclin-dependent kinase-like 1	Error:Variant_position_missing_in_Q00532_after_alignment						cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity			ovary(1)|stomach(1)	2	all_epithelial(31;0.000746)|Breast(41;0.0102)					TGTCCTTGACCTCCAACTCCG	0.478		NA											21	34					0	0	0	0
FBXO34	55030	broad.mit.edu	37	14	55818402	55818402	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr14:55818402G>A	uc001xbu.2	+	2	1539	c.1294G>A	c.(1294-1296)GTT>ATT	p.V432I	FBXO34_uc001xbv.2_RNA|FBXO34_uc010aoo.2_Missense_Mutation_p.V432I	NM_017943	NP_060413	Q9NWN3	FBX34_HUMAN	F-box only protein 34	432										ovary(2)|lung(2)|skin(1)	5						CACAGATGCTGTTGATTGTAT	0.418		NA											16	282					0	0	0	0
DACT1	51339	broad.mit.edu	37	14	59112862	59112862	+	Silent	SNP	A	A	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr14:59112862A>G	uc001xdw.2	+	4	1685	c.1521A>G	c.(1519-1521)AAA>AAG	p.K507K	DACT1_uc010trv.1_Silent_p.K226K|DACT1_uc001xdx.2_Silent_p.K470K|DACT1_uc010trw.1_Silent_p.K226K	NM_016651	NP_057735	Q9NYF0	DACT1_HUMAN	dapper 1 isoform 1	507					multicellular organismal development|Wnt receptor signaling pathway	cytoplasm|nucleus				large_intestine(2)|lung(2)|ovary(1)	5						AGCCCCTGAAAAAGATGTCAC	0.592		NA											159	29					0	0	0	0
C14orf149	112849	broad.mit.edu	37	14	59950740	59950741	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr14:59950740_59950741CC>AA	uc001xee.1	-	1	333_334	c.294_295GG>TT	c.(292-297)GAGGGC>GATTGC	p.98_99EG>DC	C14orf149_uc010trx.1_Missense_Mutation_p.98_99EG>DC|JKAMP_uc001xef.3_5'Flank|JKAMP_uc001xeh.3_5'Flank|JKAMP_uc001xeg.3_5'Flank|JKAMP_uc010try.1_5'Flank|JKAMP_uc001xei.3_5'Flank	NM_144581	NP_653182	Q96EM0	PRCM_HUMAN	proline racemase-like	98_99							proline racemase activity			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.14)	L-Proline(DB00172)	GAGCTGTAGCCCTCGTTGTGCA	0.708		NA									OREG0022712	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	21					0	0	0	0
PPM1A	5494	broad.mit.edu	37	14	60756619	60756619	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr14:60756619G>T	uc010apn.2	+	5	1450	c.1048G>T	c.(1048-1050)GAA>TAA	p.E350*	PPM1A_uc001xew.3_Nonsense_Mutation_p.E423*|PPM1A_uc001xey.3_Nonsense_Mutation_p.E350*	NM_021003	NP_066283	P35813	PPM1A_HUMAN	protein phosphatase 1A isoform 1	350					cell cycle arrest|insulin receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway|protein dephosphorylation|Wnt receptor signaling pathway	cytosol|nucleus|protein serine/threonine phosphatase complex	magnesium ion binding|manganese ion binding|protein serine/threonine phosphatase activity|signal transducer activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.046)		ACCAGGGGGTGAATTGGCAAG	0.438		NA											28	37					8.58e-18	1.2e-17	1	0
SPTB	6710	broad.mit.edu	37	14	65268548	65268548	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr14:65268548G>A	uc001xht.2	-	5	625	c.571C>T	c.(571-573)CCT>TCT	p.P191S	SPTB_uc001xhr.2_Missense_Mutation_p.P191S|SPTB_uc001xhs.2_Missense_Mutation_p.P191S|SPTB_uc001xhu.2_Missense_Mutation_p.P191S	NM_000347	NP_000338	P11277	SPTB1_HUMAN	spectrin beta isoform b	191	Actin-binding.|CH 2.				actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		TTAACATGAGGGTAGCTGCAT	0.463		NA									OREG0022735	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	129	17					0	0	0	0
C14orf115	55237	broad.mit.edu	37	14	74825284	74825284	+	Missense_Mutation	SNP	G	G	A	rs45447993	by1000genomes	TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr14:74825284G>A	uc001xpw.3	+	2	1989	c.1798G>A	c.(1798-1800)GAG>AAG	p.E600K		NM_018228	NP_060698	Q9H8Y1	VRTN_HUMAN	hypothetical protein LOC55237	600					transposition, DNA-mediated		DNA binding|transposase activity				0				BRCA - Breast invasive adenocarcinoma(234;0.00147)		AGAAGATGTAGAGGGAGGGCC	0.662		NA											52	20					0	0	0	0
ISM2	145501	broad.mit.edu	37	14	77948965	77948965	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr14:77948965C>A	uc001xtz.2	-	4	747	c.673G>T	c.(673-675)GAC>TAC	p.D225Y	ISM2_uc001xua.2_Intron|ISM2_uc001xty.2_Missense_Mutation_p.D137Y|ISM2_uc010tvl.1_Missense_Mutation_p.D144Y	NM_199296	NP_954993	Q6H9L7	ISM2_HUMAN	isthmin 2 homolog isoform 1	225						extracellular region				skin(1)	1						GCCAACAGGTCTATCGACACC	0.612		NA											107	151					1.07e-41	1.66e-41	1	0
SEL1L	6400	broad.mit.edu	37	14	81953772	81953772	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr14:81953772C>T	uc010tvv.1	-	16	1711	c.1594G>A	c.(1594-1596)GGC>AGC	p.G532S		NM_005065	NP_005056	Q9UBV2	SE1L1_HUMAN	sel-1 suppressor of lin-12-like precursor	532	Lumenal (Potential).|Interaction with ERLEC1, OS9 and SYVN1.|Sel1-like 9.				Notch signaling pathway	endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.0299)		ACGCCGGTGCCACTGGCATGC	0.478		NA											60	17					0	0	0	0
FLRT2	23768	broad.mit.edu	37	14	86088031	86088031	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr14:86088031C>G	uc001xvr.2	+	2	940	c.173C>G	c.(172-174)CCT>CGT	p.P58R	FLRT2_uc010atd.2_Missense_Mutation_p.P58R	NM_013231	NP_037363	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	58	Extracellular (Potential).|LRRNT.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			ovary(3)|haematopoietic_and_lymphoid_tissue(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.0319)		ACCTCAGTGCCTCTTGGGATC	0.522		NA											157	48					0	0	0	0
CYP46A1	10858	broad.mit.edu	37	14	100157458	100157458	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr14:100157458G>T	uc001ygo.2	+	2	160	c.160G>T	c.(160-162)GAG>TAG	p.E54*	CYP46A1_uc001ygn.1_Missense_Mutation_p.M1I	NM_006668	NP_006659	Q9Y6A2	CP46A_HUMAN	cytochrome P450, family 46	54					bile acid biosynthetic process|cholesterol catabolic process|nervous system development|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol 24-hydroxylase activity|electron carrier activity|heme binding|steroid hydroxylase activity				0		Melanoma(154;0.0866)|all_epithelial(191;0.179)				GAAAAAGGATGAGGTTGGTGG	0.502		NA											76	115					3.64e-30	5.54e-30	1	0
DEGS2	123099	broad.mit.edu	37	14	100615483	100615483	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr14:100615483G>C	uc001ygx.2	-	2	735	c.647C>G	c.(646-648)TCC>TGC	p.S216C		NM_206918	NP_996801	Q6QHC5	DEGS2_HUMAN	degenerative spermatocyte homolog 2, lipid	216	Helical; (Potential).				fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	sphingosine hydroxylase activity				0		Melanoma(154;0.212)				GCCCAGGAAGGAGCTGGCCAG	0.647		NA											83	17					0	0	0	0
AHNAK2	113146	broad.mit.edu	37	14	105419983	105419983	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr14:105419983C>A	uc010axc.1	-	7	1925	c.1805G>T	c.(1804-1806)AGA>ATA	p.R602I	AHNAK2_uc001ypx.2_Missense_Mutation_p.R502I	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	602						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GGCTTTTTCTCTGCCTGTCTT	0.502		NA											49	542					6.03e-31	9.2e-31	1	0
MKRN3	7681	broad.mit.edu	37	15	23811411	23811411	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr15:23811411C>A	uc001ywh.3	+	1	958	c.482C>A	c.(481-483)CCG>CAG	p.P161Q	MKRN3_uc001ywi.2_Intron|MKRN3_uc010ayi.1_Missense_Mutation_p.P161Q	NM_005664	NP_005655	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	161						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			lung(6)|large_intestine(2)|ovary(2)	10		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		GAAGCCCCCCCGGCTGCATCC	0.642		NA											17	24					1.15e-07	1.38e-07	1	0
MKRN3	7681	broad.mit.edu	37	15	23811593	23811593	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr15:23811593G>T	uc001ywh.3	+	1	1140	c.664G>T	c.(664-666)GAG>TAG	p.E222*	MKRN3_uc001ywi.2_Intron|MKRN3_uc010ayi.1_Nonsense_Mutation_p.E222*	NM_005664	NP_005655	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	222						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			lung(6)|large_intestine(2)|ovary(2)	10		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		ATCTGCCCCCGAGGCTCCTCT	0.597		NA											10	24					0.000978159	0.00105749	1	0
C15orf2	23742	broad.mit.edu	37	15	24922301	24922301	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr15:24922301G>T	uc001ywo.2	+	1	1761	c.1287G>T	c.(1285-1287)TTG>TTT	p.L429F		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	429	Pro-rich.				cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		TCCCTGACTTGGCTGACCTGG	0.542		NA											32	56					2.08e-15	2.87e-15	1	0
GABRA5	2558	broad.mit.edu	37	15	27128609	27128609	+	Silent	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr15:27128609C>T	uc001zbd.1	+	7	741	c.402C>T	c.(400-402)TTC>TTT	p.F134F	GABRB3_uc001zbb.2_Intron	NM_000810	NP_000801	P31644	GBRA5_HUMAN	gamma-aminobutyric acid A receptor, alpha 5	134	Extracellular (Potential).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(1)	1		all_lung(180;4.59e-13)|Breast(32;0.000563)|Colorectal(260;0.227)		all cancers(64;1.45e-08)|Epithelial(43;4.96e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0232)|Lung(196;0.182)	Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	CAGACACGTTCTTCCACAACG	0.572		NA											6	47					0	0	0	0
MTMR15	22909	broad.mit.edu	37	15	31197880	31197880	+	Silent	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr15:31197880G>A	uc001zff.2	+	2	1305	c.1014G>A	c.(1012-1014)GAG>GAA	p.E338E	MTMR15_uc001zfc.3_Silent_p.E338E|MTMR15_uc010azw.2_Silent_p.E338E|MTMR15_uc001zfd.3_Silent_p.E338E|MTMR15_uc001zfe.2_5'UTR	NM_014967	NP_055782	Q9Y2M0	FAN1_HUMAN	myotubularin related protein 15 isoform a	338					double-strand break repair via homologous recombination|nucleotide-excision repair, DNA incision	nucleus	5'-3' exonuclease activity|5'-flap endonuclease activity|DNA binding|magnesium ion binding|phosphodiesterase I activity|ubiquitin binding				0		all_lung(180;2.23e-09)		all cancers(64;4.72e-15)|Epithelial(43;5.4e-11)|GBM - Glioblastoma multiforme(186;0.000136)|BRCA - Breast invasive adenocarcinoma(123;0.00402)|Lung(196;0.168)		ACATCCAAGAGGCTCCTCTGC	0.458		NA						Direct_reversal_of_damage|Editing_and_processing_nucleases					30	68					0	0	0	0
SLC12A6	9990	broad.mit.edu	37	15	34543234	34543234	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr15:34543234G>T	uc001zhw.2	-	10	1522	c.1358C>A	c.(1357-1359)CCC>CAC	p.P453H	SLC12A6_uc001zhv.2_Missense_Mutation_p.P402H|SLC12A6_uc001zhx.2_Missense_Mutation_p.P438H|SLC12A6_uc001zhy.2_RNA|SLC12A6_uc001zhz.2_RNA|SLC12A6_uc001zia.2_Missense_Mutation_p.P394H|SLC12A6_uc001zib.2_Missense_Mutation_p.P444H|SLC12A6_uc001zic.2_Missense_Mutation_p.P453H|SLC12A6_uc010bau.2_Missense_Mutation_p.P453H|SLC12A6_uc001zid.2_Missense_Mutation_p.P394H|SLC12A6_uc001zht.2_5'Flank|SLC12A6_uc001zhu.2_Missense_Mutation_p.P265H	NM_133647	NP_598408	Q9UHW9	S12A6_HUMAN	solute carrier family 12, member 6 isoform a	453	Cytoplasmic (Potential).				angiogenesis|cellular hypotonic salinity response|potassium ion transport|sodium ion transport	basolateral plasma membrane|integral to membrane	potassium:chloride symporter activity			central_nervous_system(5)|ovary(1)|skin(1)	7		all_lung(180;2.78e-08)		all cancers(64;3.43e-17)|GBM - Glioblastoma multiforme(113;2.6e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0301)	Potassium Chloride(DB00761)	CTCTCCCTTGGGTAGGTAATT	0.383		NA											28	53					2.49e-23	3.69e-23	1	0
C15orf55	256646	broad.mit.edu	37	15	34640393	34640393	+	Silent	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr15:34640393C>T	uc001zif.2	+	2	395	c.240C>T	c.(238-240)CTC>CTT	p.L80L	C15orf55_uc010ucc.1_Silent_p.L108L|C15orf55_uc010ucd.1_Silent_p.L98L	NM_175741	NP_786883	Q86Y26	NUT_HUMAN	nuclear protein in testis	80	Pro-rich.					cytoplasm|nucleus			BRD4_ENST00000263377/C15orf55(24)|BRD3/C15orf55(3)	midline_organs(25)|ovary(2)|lung(2)|skin(1)	30		all_lung(180;2.78e-08)		all cancers(64;4.53e-18)|GBM - Glioblastoma multiforme(113;8.29e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0249)		GCCCTTGCCTCAGTGGGGCTG	0.557		NA	T	BRD3|BRD4	lethal midline carcinoma								29	121					0	0	0	0
RASGRP1	10125	broad.mit.edu	37	15	38852064	38852064	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr15:38852064C>T	uc001zke.3	-	2	356	c.178G>A	c.(178-180)GCC>ACC	p.A60T	RASGRP1_uc001zkd.3_Missense_Mutation_p.A60T	NM_005739	NP_005730	O95267	GRP1_HUMAN	RAS guanyl releasing protein 1 isoform a	60	Ras exchanger motif region; required for transforming activity (By similarity).|N-terminal Ras-GEF.				cell differentiation|platelet activation|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol|endoplasmic reticulum membrane|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|lipid binding|protein binding			large_intestine(1)|ovary(1)	2		all_cancers(109;6.38e-17)|all_epithelial(112;5.51e-15)|Lung NSC(122;2.12e-11)|all_lung(180;5.63e-10)|Melanoma(134;0.0574)		GBM - Glioblastoma multiforme(113;1.97e-07)|BRCA - Breast invasive adenocarcinoma(123;0.00248)		TCCAGGCTGGCTCCTTTGGCT	0.502		NA											11	34					0	0	0	0
MAPKBP1	23005	broad.mit.edu	37	15	42117604	42117604	+	Silent	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr15:42117604C>T	uc001zok.3	+	32	4801	c.4515C>T	c.(4513-4515)GCC>GCT	p.A1505A	MAPKBP1_uc001zoj.3_Silent_p.A1499A|MAPKBP1_uc010bcj.2_Silent_p.A1006A|MAPKBP1_uc010bci.2_Silent_p.A1222A|MAPKBP1_uc010udb.1_Silent_p.A1338A|MAPKBP1_uc010bck.2_Silent_p.A716A|MAPKBP1_uc010bcl.2_Silent_p.A1004A|JMJD7-PLA2G4B_uc010bcm.1_5'Flank|JMJD7-PLA2G4B_uc001zom.2_5'Flank|JMJD7-PLA2G4B_uc001zon.2_5'Flank|JMJD7-PLA2G4B_uc001zoo.3_5'Flank|JMJD7-PLA2G4B_uc010bcn.2_5'Flank	NM_001128608	NP_001122080	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein	1505										central_nervous_system(5)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	10		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		TGCTTCGAGCCGTGGAACGGC	0.607		NA											13	22					0	0	0	0
PLA2G4E	123745	broad.mit.edu	37	15	42278076	42278076	+	Silent	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr15:42278076G>A	uc001zow.1	-	17	2076	c.2076C>T	c.(2074-2076)CTC>CTT	p.L692L	PLA2G4E_uc010udc.1_Silent_p.L164L|PLA2G4E_uc001zov.1_Silent_p.L345L	NM_001080490	NP_001073959	Q3MJ16	PA24E_HUMAN	phospholipase A2, group 4E	709	PLA2c.				phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity				0		all_cancers(109;8.09e-13)|all_epithelial(112;2.03e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.0273)		OV - Ovarian serous cystadenocarcinoma(18;7.61e-18)|GBM - Glioblastoma multiforme(94;3.07e-06)		GGTGGATGATGAGGTCGGCTT	0.617		NA											6	10					0	0	0	0
TTBK2	146057	broad.mit.edu	37	15	43122142	43122142	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr15:43122142G>C	uc001zqo.2	-	5	865	c.426C>G	c.(424-426)ATC>ATG	p.I142M	TTBK2_uc010bcy.2_Missense_Mutation_p.I73M|TTBK2_uc001zqp.2_Missense_Mutation_p.I142M|TTBK2_uc010bcz.1_Missense_Mutation_p.I142M	NM_173500	NP_775771	Q6IQ55	TTBK2_HUMAN	tau tubulin kinase 2	142	Protein kinase.				cell death		ATP binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|stomach(1)|pancreas(1)|skin(1)	7		all_cancers(109;6.11e-16)|all_epithelial(112;5.5e-14)|Lung NSC(122;1.76e-08)|all_lung(180;6.04e-08)|Melanoma(134;0.0179)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;3.23e-07)		CTACCGGTTTGATGTCTCGAT	0.408		NA											24	65					0	0	0	0
SLC28A2	9153	broad.mit.edu	37	15	45560574	45560574	+	Nonsense_Mutation	SNP	C	C	T	rs142426040	byFrequency	TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr15:45560574C>T	uc001zva.2	+	13	1431	c.1366C>T	c.(1366-1368)CAG>TAG	p.Q456*		NM_004212	NP_004203	O43868	S28A2_HUMAN	solute carrier family 28 (sodium-coupled	456	Helical; (Potential).				nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding|nucleoside:sodium symporter activity|purine nucleoside transmembrane transporter activity			ovary(4)	4		all_cancers(109;8.53e-07)|all_epithelial(112;1.39e-05)|Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;3.77e-16)|GBM - Glioblastoma multiforme(94;2.71e-06)		GCTCACTTTCCAGGTAAAGGA	0.438		NA											65	97					0	0	0	0
SCG3	29106	broad.mit.edu	37	15	51984366	51984366	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr15:51984366C>A	uc002abh.2	+	7	1109	c.701C>A	c.(700-702)GCA>GAA	p.A234E	SCG3_uc010ufz.1_Missense_Mutation_p.A2E	NM_013243	NP_037375	Q8WXD2	SCG3_HUMAN	secretogranin III isoform 1 precursor	234					platelet activation|platelet degranulation	extracellular region|stored secretory granule				ovary(1)	1				all cancers(107;0.00488)		ACTCCAATGGCAGCAATTCAA	0.378		NA											17	98					1.64e-05	1.86e-05	1	0
UNC13C	440279	broad.mit.edu	37	15	54305610	54305610	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr15:54305610G>T	uc002ack.2	+	1	510	c.510G>T	c.(508-510)GAG>GAT	p.E170D		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	170					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		CTGACGGGGAGCGTACTCTAC	0.473		NA											25	70					1.43e-11	1.86e-11	1	0
GCOM1	145781	broad.mit.edu	37	15	57929944	57929944	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr15:57929944G>A	uc002aei.2	+	9	1104	c.985G>A	c.(985-987)GGG>AGG	p.G329R	GCOM1_uc002aej.2_Missense_Mutation_p.G329R|GCOM1_uc002aek.2_RNA|GCOM1_uc002ael.2_RNA|GCOM1_uc002aem.2_Missense_Mutation_p.G329R|GCOM1_uc002aeq.2_RNA|GCOM1_uc002aen.2_RNA|GCOM1_uc010bfy.2_RNA|GCOM1_uc002aeo.2_Missense_Mutation_p.G329R|GCOM1_uc002aep.2_RNA|GCOM1_uc010bfx.2_RNA	NM_001018100	NP_001018110	P0CAP1	GCOM1_HUMAN	GRINL1A upstream protein isoform 7	329	Potential.				intracellular signal transduction	extrinsic to internal side of plasma membrane|I band				ovary(1)	1						AGAAATGTCTGGGGAGTTAAC	0.383		NA											6	9					0	0	0	0
NOX5	79400	broad.mit.edu	37	15	69347810	69347810	+	Silent	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr15:69347810C>T	uc002ars.1	+	15	2156	c.2136C>T	c.(2134-2136)CGC>CGT	p.R712R	NOX5_uc002arp.1_Silent_p.R694R|NOX5_uc002arq.1_Silent_p.R666R|NOX5_uc010bid.1_Silent_p.R677R|NOX5_uc002arr.1_Silent_p.R684R|NOX5_uc010bie.1_Silent_p.R512R|NOX5_uc010bif.1_RNA	NM_024505	NP_078781	Q96PH1	NOX5_HUMAN	NADPH oxidase, EF-hand calcium binding domain 5	712	Extracellular (Potential).				angiogenesis|angiogenesis|cytokine secretion|cytokinesis|electron transport chain|endothelial cell proliferation|induction of apoptosis|positive regulation of reactive oxygen species metabolic process|regulation of fusion of sperm to egg plasma membrane|regulation of proton transport|superoxide anion generation	endoplasmic reticulum|endoplasmic reticulum|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|hydrogen ion channel activity|NADP binding|superoxide-generating NADPH oxidase activity			breast(1)|pancreas(1)	2						TGCAGACGCGCACCCAGCCTG	0.607		NA											18	27					0	0	0	0
ISL2	64843	broad.mit.edu	37	15	76630854	76630854	+	Silent	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr15:76630854C>A	uc002bbw.1	+	3	588	c.510C>A	c.(508-510)CCC>CCA	p.P170P		NM_145805	NP_665804	Q96A47	ISL2_HUMAN	ISL LIM homeobox 2	170						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						TGCATCTGCCCGGTAAGCGCG	0.468		NA											18	22					3.53e-06	4.11e-06	1	0
IREB2	3658	broad.mit.edu	37	15	78758820	78758820	+	Silent	SNP	A	A	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr15:78758820A>G	uc002bdr.2	+	5	780	c.618A>G	c.(616-618)CAA>CAG	p.Q206Q	IREB2_uc010unb.1_5'UTR|IREB2_uc002bdq.2_Silent_p.Q206Q	NM_004136	NP_004127	P48200	IREB2_HUMAN	iron-responsive element binding protein 2	206							4 iron, 4 sulfur cluster binding|metal ion binding|protein binding				0				UCEC - Uterine corpus endometrioid carcinoma (272;0.232)		TTCATTTGCAACCAGTGCCTG	0.383		NA											23	51					0	0	0	0
IREB2	3658	broad.mit.edu	37	15	78765606	78765606	+	Silent	SNP	A	A	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr15:78765606A>G	uc002bdr.2	+	8	1068	c.906A>G	c.(904-906)GAA>GAG	p.E302E	IREB2_uc010unb.1_Silent_p.E52E|IREB2_uc002bdq.2_Silent_p.E302E	NM_004136	NP_004127	P48200	IREB2_HUMAN	iron-responsive element binding protein 2	302							4 iron, 4 sulfur cluster binding|metal ion binding|protein binding				0				UCEC - Uterine corpus endometrioid carcinoma (272;0.232)		TTGAAACAGAAGCAGTTATGC	0.388		NA											50	117					0	0	0	0
ADAMTS7	11173	broad.mit.edu	37	15	79059741	79059741	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr15:79059741C>A	uc002bej.3	-	18	3050	c.2839G>T	c.(2839-2841)GCT>TCT	p.A947S	ADAMTS7_uc010und.1_Intron	NM_014272	NP_055087	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1	947	TSP type-1 4.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0						TTCCCCACAGCCCAGGTGGCC	0.652		NA											16	19					9.17e-09	1.14e-08	1	0
ZFAND6	54469	broad.mit.edu	37	15	80423525	80423525	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr15:80423525C>T	uc002bfe.1	+	6	679	c.368C>T	c.(367-369)TCA>TTA	p.S123L	ZFAND6_uc002bff.1_Missense_Mutation_p.S123L|ZFAND6_uc002bfg.1_Missense_Mutation_p.S111L|ZFAND6_uc002bfh.1_Missense_Mutation_p.S123L|ZFAND6_uc002bfi.1_Missense_Mutation_p.S123L	NM_019006	NP_061879	Q6FIF0	ZFAN6_HUMAN	zinc finger, AN1-type domain 6	123							DNA binding|zinc ion binding				0						TTGTTAGCTTCAGTATCAGAC	0.393		NA											9	94					0	0	0	0
ZNF592	9640	broad.mit.edu	37	15	85326320	85326320	+	Silent	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr15:85326320C>T	uc002bld.2	+	4	750	c.414C>T	c.(412-414)TTC>TTT	p.F138F	ZNF592_uc010upb.1_RNA	NM_014630	NP_055445	Q92610	ZN592_HUMAN	zinc finger protein 592	138					cell death|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(2)	6			BRCA - Breast invasive adenocarcinoma(143;0.0587)			TACCCACCTTCAACCAGTTCA	0.478		NA											42	139					0	0	0	0
SLC28A1	9154	broad.mit.edu	37	15	85431063	85431063	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr15:85431063G>T	uc002blg.2	+	3	274	c.72G>T	c.(70-72)ATG>ATT	p.M24I	SLC28A1_uc010upd.1_5'UTR|SLC28A1_uc010bnb.2_Missense_Mutation_p.M24I|SLC28A1_uc010upe.1_Missense_Mutation_p.M24I|SLC28A1_uc010upf.1_Missense_Mutation_p.M24I|SLC28A1_uc010upg.1_Missense_Mutation_p.M24I|SLC28A1_uc002blf.2_Missense_Mutation_p.M24I	NM_004213	NP_004204	O00337	S28A1_HUMAN	solute carrier family 28, member 1 isoform 1	24					nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding			skin(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(143;0.0587)			TGGAGAACATGGGGGCTGATT	0.567		NA											31	50					1.83e-34	2.8e-34	1	0
RHCG	51458	broad.mit.edu	37	15	90019999	90019999	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr15:90019999G>T	uc002bnz.2	-	9	1322	c.1298C>A	c.(1297-1299)GCG>GAG	p.A433E	RHCG_uc002bny.2_Missense_Mutation_p.A204E|RHCG_uc002boa.2_RNA	NM_016321	NP_057405	Q9UBD6	RHCG_HUMAN	Rh family, C glycoprotein	433	Cytoplasmic (Potential).				amine transport|cellular ion homeostasis|epithelial cell differentiation|transepithelial ammonium transport	apical plasma membrane|basolateral plasma membrane|cytoplasmic vesicle|integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			kidney(1)	1	Lung NSC(78;0.0237)|all_lung(78;0.0478)					CCAGTAGACCGCATCCTCAAA	0.562		NA											26	50					2.09e-25	3.14e-25	1	0
TELO2	9894	broad.mit.edu	37	16	1552736	1552736	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr16:1552736G>T	uc002cly.2	+	14	2035	c.1744G>T	c.(1744-1746)GCC>TCC	p.A582S		NM_016111	NP_057195	Q9Y4R8	TELO2_HUMAN	TEL2, telomere maintenance 2, homolog	582						chromosome, telomeric region|cytoplasm|membrane|nucleus	protein binding				0		Hepatocellular(780;0.219)				AGCCCTGGTGGCCGTCACGGT	0.672		NA											33	92					1.59e-26	2.39e-26	1	0
ZNF200	7752	broad.mit.edu	37	16	3274518	3274518	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr16:3274518C>T	uc002cuj.2	-	5	1194	c.562G>A	c.(562-564)GAT>AAT	p.D188N	ZNF200_uc002cum.3_Missense_Mutation_p.D187N|ZNF200_uc010bti.2_Missense_Mutation_p.D187N|ZNF200_uc002cuk.2_Missense_Mutation_p.D188N|ZNF200_uc002cui.2_Missense_Mutation_p.D187N|ZNF200_uc002cul.3_Missense_Mutation_p.D187N	NM_003454	NP_003445	P98182	ZN200_HUMAN	zinc finger protein 200 isoform 1	188					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0						AAGGAAGAATCCATTTCATCA	0.398		NA											34	57					0	0	0	0
A2BP1	54715	broad.mit.edu	37	16	7102088	7102088	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr16:7102088G>A	uc002cys.2	+	4	1004	c.16G>A	c.(16-18)GAG>AAG	p.E6K	A2BP1_uc010buf.1_Missense_Mutation_p.E6K|A2BP1_uc002cyr.1_Missense_Mutation_p.E6K|A2BP1_uc002cyt.2_Missense_Mutation_p.E6K|A2BP1_uc010uxz.1_Missense_Mutation_p.E49K|A2BP1_uc010uya.1_Missense_Mutation_p.E42K|A2BP1_uc002cyv.1_Missense_Mutation_p.E6K|A2BP1_uc010uyb.1_Missense_Mutation_p.E6K	NM_018723	NP_061193	Q9NWB1	RFOX1_HUMAN	ataxin 2-binding protein 1 isoform 4	6					mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding				0		all_cancers(2;4.54e-52)|Colorectal(2;6.95e-44)|all_epithelial(2;1.15e-37)|Lung NSC(2;0.000289)|all_lung(2;0.00148)|Myeloproliferative disorder(2;0.0122)|Medulloblastoma(2;0.0354)|all_neural(2;0.0381)|all_hematologic(2;0.0749)|Renal(2;0.0758)|Melanoma(2;0.211)		Colorectal(1;3.55e-51)|COAD - Colon adenocarcinoma(2;1.92e-46)|all cancers(1;5.36e-16)|Epithelial(1;3.98e-15)|READ - Rectum adenocarcinoma(2;3.71e-05)|GBM - Glioblastoma multiforme(1;0.0499)		TTGTGAAAGAGAGCAGCTAAG	0.398		NA											8	17					0	0	0	0
GRIN2A	2903	broad.mit.edu	37	16	9923430	9923430	+	Silent	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr16:9923430G>T	uc002czo.3	-	9	2405	c.1857C>A	c.(1855-1857)GTC>GTA	p.V619V	GRIN2A_uc010uym.1_Silent_p.V619V|GRIN2A_uc010uyn.1_Silent_p.V462V|GRIN2A_uc002czr.3_Silent_p.V619V	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	619	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TAGGATTCTGGACAGGCACGG	0.488		NA											34	64					4.32e-19	6.17e-19	1	0
GPR139	124274	broad.mit.edu	37	16	20043241	20043241	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr16:20043241C>T	uc002dgu.1	-	2	1040	c.878G>A	c.(877-879)CGC>CAC	p.R293H	GPR139_uc010vaw.1_Missense_Mutation_p.R200H	NM_001002911	NP_001002911	Q6DWJ6	GP139_HUMAN	G protein-coupled receptor 139	293	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(2)	2						TGCCATGGTGCGGAACCGCTT	0.512		NA											51	98					0	0	0	0
OTOA	146183	broad.mit.edu	37	16	21696600	21696600	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr16:21696600T>A	uc002djh.2	+	6	318	c.317T>A	c.(316-318)CTG>CAG	p.L106Q	uc002diq.3_Intron|OTOA_uc010vbj.1_Missense_Mutation_p.L27Q	NM_144672	NP_653273	Q7RTW8	OTOAN_HUMAN	otoancorin isoform 1	106					sensory perception of sound	anchored to membrane|apical plasma membrane|proteinaceous extracellular matrix				ovary(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(48;0.0414)		CCCCAGAAGCTGCTGGAGGAC	0.577		NA											28	32					0	0	0	0
EEF2K	29904	broad.mit.edu	37	16	22271832	22271832	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr16:22271832T>G	uc002dki.2	+	11	1766	c.1281T>G	c.(1279-1281)GAT>GAG	p.D427E	EEF2K_uc002dkh.2_RNA	NM_013302	NP_037434	O00418	EF2K_HUMAN	elongation factor-2 kinase	427					insulin receptor signaling pathway|translational elongation	cytosol	ATP binding|calcium ion binding|calmodulin binding|elongation factor-2 kinase activity|translation factor activity, nucleic acid binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(48;0.0223)		GAGACCATGATCATCTAGACA	0.542		NA											60	91					0	0	0	0
PALB2	79728	broad.mit.edu	37	16	23647270	23647270	+	Silent	SNP	A	A	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr16:23647270A>C	uc002dlx.1	-	4	797	c.597T>G	c.(595-597)CTT>CTG	p.L199L		NM_024675	NP_078951	Q86YC2	PALB2_HUMAN	partner and localizer of BRCA2	199	Interaction with RAD51.|Interaction with BRCA1.				double-strand break repair via homologous recombination	nucleoplasm	DNA binding|protein binding			lung(3)|breast(3)|ovary(2)|skin(1)|kidney(1)|pancreas(1)	11				GBM - Glioblastoma multiforme(48;0.0167)		TAAGACTTAAAAGGTGAGTTC	0.378		NA	F|N|Mis			Wilms tumor|medulloblastoma|AML ,breast		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia_type_N|Fanconi_Anemia|PALB2-associated_Familial_Breast_and_Pancreatic_Cancer|Pancreatic_Cancer_Familial_Clustering_of				93	135					0	0	0	0
TNRC6A	27327	broad.mit.edu	37	16	24800997	24800997	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr16:24800997G>C	uc002dmm.2	+	6	1148	c.1034G>C	c.(1033-1035)TGG>TCG	p.W345S	TNRC6A_uc010bxs.2_Missense_Mutation_p.W92S|TNRC6A_uc010vcc.1_Missense_Mutation_p.W92S|TNRC6A_uc002dmn.2_Missense_Mutation_p.W92S|TNRC6A_uc002dmo.2_Missense_Mutation_p.W92S	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	345	Sufficient for interaction with EIF2C2.|Sufficient for interaction with EIF2C1, EIF2C3 and EIF2C4.|Sufficient for interaction with EIF2C2.|Ser-rich.|Sufficient for interaction with EIF2C2.			W->A: Does not impair interaction with EIF2C2; when associated with A-313; A- 370; A-420 and A-483.	negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)		ATGAATGCTTGGGGCACTGTA	0.438		NA											45	101					0	0	0	0
C16orf93	90835	broad.mit.edu	37	16	30770417	30770417	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr16:30770417C>T	uc002dzm.2	-	8	1064	c.733G>A	c.(733-735)GAA>AAA	p.E245K	C16orf93_uc002dzn.2_Missense_Mutation_p.E310K|C16orf93_uc002dzo.2_Missense_Mutation_p.E208K	NM_001014979	NP_001014979	A1A4V9	CP093_HUMAN	hypothetical protein LOC90835	245											0						TTGCTTTCTTCTTTCTCTGCA	0.597		NA											163	144					0	0	0	0
C16orf93	90835	broad.mit.edu	37	16	30770423	30770423	+	Splice_Site	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr16:30770423C>T	uc002dzm.2	-	8	1059	c.728_splice	c.e8-1	p.E243_splice	C16orf93_uc002dzn.2_Splice_Site_p.E308_splice|C16orf93_uc002dzo.2_Splice_Site_p.E206_splice	NM_001014979	NP_001014979	A1A4V9	CP093_HUMAN	hypothetical protein LOC90835												0						TCTTCTTTCTCTGCAAACCAG	0.587		NA											148	139					0	0	0	0
C16orf93	90835	broad.mit.edu	37	16	30771764	30771764	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr16:30771764C>G	uc002dzm.2	-	4	641	c.310G>C	c.(310-312)GAG>CAG	p.E104Q	C16orf93_uc002dzn.2_Missense_Mutation_p.E104Q|C16orf93_uc002dzo.2_Missense_Mutation_p.E67Q|C16orf93_uc002dzp.2_Missense_Mutation_p.E104Q|RNF40_uc002dzq.2_5'Flank|RNF40_uc010caa.2_5'Flank|RNF40_uc010cab.2_5'Flank|RNF40_uc010vfa.1_5'Flank|RNF40_uc002dzr.2_5'Flank|RNF40_uc010vfb.1_5'Flank	NM_001014979	NP_001014979	A1A4V9	CP093_HUMAN	hypothetical protein LOC90835	104											0						TCCAGCAGCTCAGCCAGCACC	0.597		NA											33	40					0	0	0	0
PRSS8	5652	broad.mit.edu	37	16	31143906	31143906	+	Silent	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr16:31143906C>T	uc002ebc.3	-	5	881	c.549G>A	c.(547-549)CTG>CTA	p.L183L	PRSS8_uc010vfe.1_Silent_p.L129L	NM_002773	NP_002764	Q16651	PRSS8_HUMAN	prostasin preproprotein	183	Peptidase S1.				proteolysis	extracellular space|integral to membrane|plasma membrane	serine-type endopeptidase activity				0						GCTTGGGCGTCAGGAGGCTCA	0.612		NA											37	40					0	0	0	0
CDH1	999	broad.mit.edu	37	16	68842735	68842735	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr16:68842735G>A	uc002ewg.1	+	5	795	c.671G>A	c.(670-672)CGC>CAC	p.R224H	CDH1_uc010vlj.1_RNA|CDH1_uc010cfg.1_Missense_Mutation_p.R224H	NM_004360	NP_004351	P12830	CADH1_HUMAN	cadherin 1, type 1 preproprotein	224	Cadherin 1.|Extracellular (Potential).				adherens junction organization|cellular component disassembly involved in apoptosis|cellular response to indole-3-methanol|cellular response to lithium ion|homophilic cell adhesion|negative regulation of cell-cell adhesion|positive regulation of transcription factor import into nucleus|positive regulation of transcription, DNA-dependent|regulation of immune response	actin cytoskeleton|aggresome|apical junction complex|catenin complex|cell-cell adherens junction|endosome|focal adhesion|Golgi apparatus|integral to membrane|internal side of plasma membrane|lateral plasma membrane|perinuclear region of cytoplasm	cell adhesion molecule binding|gamma-catenin binding			breast(148)|stomach(71)|biliary_tract(8)|endometrium(3)|soft_tissue(2)|large_intestine(2)|urinary_tract(2)|oesophagus(2)|ovary(2)|thyroid(1)|central_nervous_system(1)|lung(1)	243		all_neural(199;0.0189)|Ovarian(137;0.0563)		Epithelial(162;8.44e-05)|all cancers(182;0.000404)|OV - Ovarian serous cystadenocarcinoma(108;0.000426)|BRCA - Breast invasive adenocarcinoma(181;0.0261)		GATAGAGAACGCATTGCCACA	0.483		NA	Mis|N|F|S		lobular breast|gastric	gastric			Hereditary_Diffuse_Gastric_Cancer				4	30					0	0	0	0
ZBTB4	57659	broad.mit.edu	37	17	7366417	7366417	+	Silent	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:7366417C>A	uc002ghc.3	-	4	2134	c.1884G>T	c.(1882-1884)CTG>CTT	p.L628L	ZBTB4_uc002ghd.3_Silent_p.L628L	NM_001128833	NP_001122305	Q9P1Z0	ZBTB4_HUMAN	zinc finger and BTB domain containing 4	628	Glu-rich.|Potential.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(1115;3.46e-05)|Myeloproliferative disorder(207;0.0255)		COAD - Colon adenocarcinoma(228;4.1e-06)|READ - Rectum adenocarcinoma(115;0.0642)		cctcTCCGCTCAGCTCCCCAG	0.398		NA											6	7					0.00307968	0.00328896	1	0
TP53	7157	broad.mit.edu	37	17	7577569	7577569	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:7577569A>T	uc002gim.2	-	7	906	c.712T>A	c.(712-714)TGT>AGT	p.C238S	TP53_uc002gig.1_Missense_Mutation_p.C238S|TP53_uc002gih.2_Missense_Mutation_p.C238S|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.C106S|TP53_uc010cng.1_Missense_Mutation_p.C106S|TP53_uc002gii.1_Missense_Mutation_p.C106S|TP53_uc010cnh.1_Missense_Mutation_p.C238S|TP53_uc010cni.1_Missense_Mutation_p.C238S|TP53_uc002gij.2_Missense_Mutation_p.C238S|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.C145S|TP53_uc002gio.2_Missense_Mutation_p.C106S	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	238	|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).	Zinc.	C -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|C -> F (in sporadic cancers; somatic mutation).|C -> S (in LFS; germline mutation and in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> H (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|C -> Y (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|C -> R (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C238Y(47)|p.C238F(32)|p.C238S(18)|p.C238R(14)|p.0?(7)|p.C238*(4)|p.C238W(2)|p.Y236_M243delYMCNSSCM(1)|p.C238fs*2(1)|p.V225fs*23(1)|p.M237_C238insX(1)|p.C238_N239insX(1)|p.C238_M246delCNSSCMGGM(1)|p.C238fs*9(1)|p.M237_N239delMCN(1)|p.C238del(1)|p.C238G(1)|p.C238fs*21(1)|p.C238C(1)|p.M237fs*1(1)|p.H233fs*6(1)|p.H233_C242del10(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GAACTGTTACACATGTAGTTG	0.567		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			23	54					0	0	0	0
DNAH2	146754	broad.mit.edu	37	17	7662908	7662908	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:7662908C>G	uc002giu.1	+	15	2631	c.2617C>G	c.(2617-2619)CTG>GTG	p.L873V		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	873	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				GAAGAATGATCTGCAAGGAAG	0.448		NA											10	98					0	0	0	0
CHD3	1107	broad.mit.edu	37	17	7814256	7814256	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:7814256A>G	uc002gje.2	+	39	5996	c.5846A>G	c.(5845-5847)AAT>AGT	p.N1949S	CHD3_uc002gjd.2_Missense_Mutation_p.N2008S|CHD3_uc002gjf.2_Missense_Mutation_p.N1915S|CHD3_uc002gjh.2_Missense_Mutation_p.N526S|CHD3_uc002gjj.2_Missense_Mutation_p.N112S	NM_001005273	NP_001005273	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	1949	Required for interaction with PCNT.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(1)	1		Prostate(122;0.202)				GCAGGCGCCAATTACAGCCAG	0.632		NA											63	92					0	0	0	0
MYH10	4628	broad.mit.edu	37	17	8451705	8451705	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:8451705G>A	uc002gll.2	-	10	1151	c.1055C>T	c.(1054-1056)TCA>TTA	p.S352L	MYH10_uc002glm.2_Missense_Mutation_p.S362L|MYH10_uc010cnx.2_Missense_Mutation_p.S361L	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	352	Myosin head-like.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						CTGTAGCACTGAAGATACTAC	0.299		NA											52	49					0	0	0	0
GLP2R	9340	broad.mit.edu	37	17	9792910	9792910	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:9792910C>A	uc002gmd.1	+	13	1550	c.1550C>A	c.(1549-1551)CCC>CAC	p.P517H		NM_004246	NP_004237	O95838	GLP2R_HUMAN	glucagon-like peptide 2 receptor precursor	517	Cytoplasmic (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger|positive regulation of cell proliferation	integral to membrane|plasma membrane				lung(2)|ovary(1)	3					Glucagon recombinant(DB00040)	GGCGCCCAGCCCCAACAGGAC	0.632		NA											24	29					1.11e-09	1.4e-09	1	0
MYH13	8735	broad.mit.edu	37	17	10206572	10206572	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:10206572C>A	uc002gmk.1	-	39	5698	c.5608G>T	c.(5608-5610)GAC>TAC	p.D1870Y		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	1870	Potential.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						TCCACCAGGTCCTGGAGCCTA	0.582		NA											92	154					1.12e-47	1.74e-47	1	0
MYH8	4626	broad.mit.edu	37	17	10310220	10310220	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:10310220G>A	uc002gmm.2	-	18	2137	c.2042C>T	c.(2041-2043)ACC>ATC	p.T681I	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	681	Myosin head-like.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						AGGAGTTTTGGTTTCATTGGG	0.388		NA							Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				8	65					0	0	0	0
MYH4	4622	broad.mit.edu	37	17	10364260	10364260	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:10364260C>A	uc002gmn.2	-	12	1231	c.1120G>T	c.(1120-1122)GAG>TAG	p.E374*	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	374	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						TCTGCCTGCTCTTCCCTTTGC	0.493		NA											50	89					9.22e-22	1.35e-21	1	0
MYH4	4622	broad.mit.edu	37	17	10366498	10366498	+	Silent	SNP	T	T	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:10366498T>C	uc002gmn.2	-	10	924	c.813A>G	c.(811-813)CTA>CTG	p.L271L	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	271	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						GGGACTTCTCTAGCAGATCTG	0.353		NA											26	43					0	0	0	0
MYH3	4621	broad.mit.edu	37	17	10554888	10554888	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:10554888T>A	uc002gmq.1	-	4	523	c.446A>T	c.(445-447)CAG>CTG	p.Q149L		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	149	Myosin head-like.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7						TGGGGCCTCCTGGCGCTTTTT	0.577		NA											86	180					0	0	0	0
MYO15A	51168	broad.mit.edu	37	17	18030103	18030103	+	Splice_Site	SNP	A	A	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:18030103A>G	uc010vxh.1	+	6	4205	c.3867_splice	c.e6-2	p.P1289_splice		NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV						sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					CTGTCTCCCCAGGCACCTCTT	0.552		NA											52	97					0	0	0	0
FBXW10	10517	broad.mit.edu	37	17	18653137	18653137	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:18653137T>C	uc002guk.2	+	3	1005	c.773T>C	c.(772-774)TTG>TCG	p.L258S	FBXW10_uc002guj.2_Missense_Mutation_p.L258S|FBXW10_uc002gul.2_Missense_Mutation_p.L258S|FBXW10_uc010cqh.1_Missense_Mutation_p.L258S	NM_031456	NP_113644	Q5XX13	FBW10_HUMAN	F-box and WD-40 domain protein 10	258										ovary(1)	1						TGCAATCTATTGGTTGACCTG	0.468		NA											50	162					0	0	0	0
MAP2K3	5606	broad.mit.edu	37	17	21205550	21205550	+	Silent	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:21205550C>A	uc002gys.2	+	6	760	c.495C>A	c.(493-495)ATC>ATA	p.I165I	MAP2K3_uc002gyt.2_Silent_p.I136I|MAP2K3_uc002gyu.2_Silent_p.I136I	NM_145109	NP_659731	P46734	MP2K3_HUMAN	mitogen-activated protein kinase kinase 3	165	Protein kinase.				activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of transcription, DNA-dependent|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0				COAD - Colon adenocarcinoma(3;0.0131)|Colorectal(15;0.0553)		CAGAGGACATCCTTGGGGAGA	0.582		NA											16	52					6.5e-13	8.65e-13	1	0
KCNJ12	3768	broad.mit.edu	37	17	21318731	21318732	+	Missense_Mutation	DNP	CG	CG	TC			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:21318731_21318732CG>TC	uc002gyv.1	+	3	782_783	c.77_78CG>TC	c.(76-78)TCG>TTC	p.S26F		NM_021012	NP_066292	Q14500	IRK12_HUMAN	potassium inwardly-rectifying channel, subfamily	26	Cytoplasmic (By similarity).				blood circulation|muscle contraction|regulation of heart contraction|synaptic transmission	integral to membrane	inward rectifier potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			ovary(3)|skin(1)	4				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)	Dofetilide(DB00204)	GTCACCATGTCGGGCGCCAACG	0.658		NA								Prostate(3;0.18)			4	45					0	0	0	0
NOS2	4843	broad.mit.edu	37	17	26084314	26084314	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:26084314C>A	uc002gzu.2	-	27	3684	c.3420G>T	c.(3418-3420)AGG>AGT	p.R1140S		NM_000625	NP_000616	P35228	NOS2_HUMAN	nitric oxide synthase 2A	1140					arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			skin(2)|ovary(1)|breast(1)	4					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	GCACCGCCACCCTGTCCTTCT	0.537		NA									OREG0024267	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	31	57					4.53e-37	6.97e-37	1	0
SUPT6H	6830	broad.mit.edu	37	17	27008409	27008409	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:27008409G>T	uc002hby.2	+	12	1575	c.1485G>T	c.(1483-1485)GAG>GAT	p.E495D	SUPT6H_uc010crt.2_Missense_Mutation_p.E495D	NM_003170	NP_003161	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog	495					chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Lung NSC(42;0.00431)					TCAGGGAAGAGGGAGATGAAG	0.338		NA											24	41					6.13e-19	8.71e-19	1	0
ACCN1	40	broad.mit.edu	37	17	31340990	31340990	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:31340990G>T	uc002hhu.2	-	10	1806	c.1532C>A	c.(1531-1533)GCC>GAC	p.A511D	ACCN1_uc002hht.2_Missense_Mutation_p.A562D	NM_001094	NP_001085	Q16515	ACCN1_HUMAN	amiloride-sensitive cation channel 1, neuronal	511	Cytoplasmic (By similarity).				central nervous system development|peripheral nervous system development|synaptic transmission	integral to plasma membrane	ligand-gated sodium channel activity|protein binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Breast(31;0.042)|Ovarian(249;0.202)		UCEC - Uterine corpus endometrioid carcinoma (308;0.13)|BRCA - Breast invasive adenocarcinoma(366;0.215)	Amiloride(DB00594)	GTGTCAGCAGGCAATCTCCTC	0.572		NA											4	6					1.24e-05	1.41e-05	1	0
CCL1	6346	broad.mit.edu	37	17	32690143	32690143	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:32690143A>T	uc002hid.1	-	1	110	c.38T>A	c.(37-39)CTA>CAA	p.L13Q		NM_002981	NP_002972	P22362	CCL1_HUMAN	small inducible cytokine A1 precursor	13					cellular calcium ion homeostasis|chemotaxis|immune response|signal transduction|viral reproduction	extracellular space	chemokine activity				0		Ovarian(249;0.0443)|Breast(31;0.133)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)|BRCA - Breast invasive adenocarcinoma(366;0.155)		CATCCCAGCTAGCAGCAAGCA	0.562		NA											20	30					0	0	0	0
SLFN13	146857	broad.mit.edu	37	17	33768373	33768373	+	Silent	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:33768373G>A	uc002hjk.1	-	4	2265	c.1935C>T	c.(1933-1935)ATC>ATT	p.I645I	SLFN13_uc010wch.1_Silent_p.I645I|SLFN13_uc002hjl.2_Silent_p.I645I|SLFN13_uc010ctt.2_Silent_p.I327I|SLFN13_uc002hjm.2_Silent_p.I314I	NM_144682	NP_653283	Q68D06	SLN13_HUMAN	schlafen family member 13	645						intracellular	ATP binding			ovary(1)|breast(1)	2				UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		CTGCTCGGCAGATATTTCTAT	0.388		NA											26	53					0	0	0	0
TOP2A	7153	broad.mit.edu	37	17	38564238	38564238	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:38564238C>A	uc002huq.2	-	12	1607	c.1481G>T	c.(1480-1482)CGA>CTA	p.R494L	TOP2A_uc002hur.1_Missense_Mutation_p.R135L	NM_001067	NP_001058	P11388	TOP2A_HUMAN	DNA topoisomerase II, alpha isozyme	494					apoptotic chromosome condensation|DNA ligation|DNA repair|DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|phosphatidylinositol-mediated signaling|positive regulation of apoptosis|positive regulation of retroviral genome replication|resolution of meiotic recombination intermediates|sister chromatid segregation	cytoplasm|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|drug binding|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity|ubiquitin binding			ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00183)		Amsacrine(DB00276)|Ciprofloxacin(DB00537)|Dexrazoxane(DB00380)|Doxorubicin(DB00997)|Enoxacin(DB00467)|Epirubicin(DB00445)|Etoposide(DB00773)|Fleroxacin(DB04576)|Gatifloxacin(DB01044)|Idarubicin(DB01177)|Levofloxacin(DB01137)|Lomefloxacin(DB00978)|Lucanthone(DB04967)|Mitoxantrone(DB01204)|Moxifloxacin(DB00218)|Norfloxacin(DB01059)|Ofloxacin(DB01165)|Pefloxacin(DB00487)|Podofilox(DB01179)|Sparfloxacin(DB01208)|Teniposide(DB00444)|Trovafloxacin(DB00685)|Valrubicin(DB00385)	AGAAGCTTCTCGAACATTGAG	0.373		NA											36	68					1.6e-28	2.42e-28	1	0
KRT10	3858	broad.mit.edu	37	17	38975866	38975866	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:38975866C>G	uc002hvi.2	-	6	1302	c.1276G>C	c.(1276-1278)GAG>CAG	p.E426Q	KRT10_uc010cxd.2_RNA|TMEM99_uc002hvj.1_Intron	NM_000421	NP_000412	P13645	K1C10_HUMAN	keratin 10	426	Rod.|Gly-rich.|Coil 2.				epidermis development		protein binding|structural constituent of epidermis				0		Breast(137;0.000301)				TTCTGGCACTCGGTTTCAGCT	0.483		NA											6	135					0	0	0	0
CNTNAP1	8506	broad.mit.edu	37	17	40847817	40847817	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:40847817A>T	uc002iay.2	+	19	3487	c.3271A>T	c.(3271-3273)AGC>TGC	p.S1091C	CNTNAP1_uc010wgs.1_RNA	NM_003632	NP_003623	P78357	CNTP1_HUMAN	contactin associated protein 1 precursor	1091	Laminin G-like 4.|Extracellular (Potential).				axon guidance|cell adhesion	paranode region of axon	receptor activity|receptor binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(3)|breast(3)|upper_aerodigestive_tract(1)|lung(1)	8		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.143)		CTTCAGCACCAGCTCCGCCCC	0.617		NA											34	47					0	0	0	0
G6PC	2538	broad.mit.edu	37	17	41052904	41052904	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:41052904G>A	uc002icb.1	+	1	90	c.11G>A	c.(10-12)GGA>GAA	p.G4E	LOC388387_uc002ibz.2_5'Flank|LOC388387_uc002iby.2_5'Flank|LOC388387_uc002ica.2_5'Flank|LOC388387_uc010whe.1_5'Flank|G6PC_uc010whf.1_Missense_Mutation_p.G6E	NM_000151	NP_000142	P35575	G6PC_HUMAN	glucose-6-phosphatase, catalytic subunit	4	Lumenal (Potential).				gluconeogenesis|glucose homeostasis|transmembrane transport	integral to endoplasmic reticulum membrane	glucose-6-phosphatase activity|phosphate binding			ovary(1)|breast(1)|kidney(1)|skin(1)	4		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.113)		ATGGAGGAAGGAATGAATGTT	0.498		NA							Glycogen_Storage_Disease_type_Ia				10	46					0	0	0	0
CACNA1G	8913	broad.mit.edu	37	17	48676874	48676874	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:48676874G>T	uc002irk.1	+	17	3716	c.3344G>T	c.(3343-3345)CGT>CTT	p.R1115L	CACNA1G_uc002iri.1_Missense_Mutation_p.R1115L|CACNA1G_uc002irj.1_Missense_Mutation_p.R1092L|CACNA1G_uc002irl.1_Missense_Mutation_p.R1092L|CACNA1G_uc002irm.1_Missense_Mutation_p.R1092L|CACNA1G_uc002irn.1_Missense_Mutation_p.R1092L|CACNA1G_uc002iro.1_Missense_Mutation_p.R1092L|CACNA1G_uc002irp.1_Missense_Mutation_p.R1115L|CACNA1G_uc002irq.1_Missense_Mutation_p.R1092L|CACNA1G_uc002irr.1_Missense_Mutation_p.R1115L|CACNA1G_uc002irs.1_Missense_Mutation_p.R1115L|CACNA1G_uc002irt.1_Missense_Mutation_p.R1115L|CACNA1G_uc002irv.1_Missense_Mutation_p.R1115L|CACNA1G_uc002irw.1_Missense_Mutation_p.R1092L|CACNA1G_uc002iru.1_Missense_Mutation_p.R1092L|CACNA1G_uc002irx.1_Missense_Mutation_p.R1028L|CACNA1G_uc002iry.1_Missense_Mutation_p.R1028L|CACNA1G_uc002irz.1_Missense_Mutation_p.R1028L|CACNA1G_uc002isa.1_Missense_Mutation_p.R1028L|CACNA1G_uc002isb.1_Missense_Mutation_p.R1028L|CACNA1G_uc002isc.1_Missense_Mutation_p.R1028L|CACNA1G_uc002isd.1_Missense_Mutation_p.R1028L|CACNA1G_uc002ise.1_Missense_Mutation_p.R1028L|CACNA1G_uc002isf.1_Missense_Mutation_p.R1028L|CACNA1G_uc002isg.1_Missense_Mutation_p.R1028L|CACNA1G_uc002ish.1_Missense_Mutation_p.R1028L|CACNA1G_uc002isi.1_Missense_Mutation_p.R1005L|CACNA1G_uc002isj.2_5'UTR	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	1115	Cytoplasmic (Potential).				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	AGCCTCGGCCGTGCACCCAGC	0.677		NA											10	9					4.69e-08	5.73e-08	1	0
C17orf47	284083	broad.mit.edu	37	17	56620307	56620309	+	Missense_Mutation	TNP	GGC	GGC	TTT			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:56620307_56620309GGC>TTT	uc002iwq.1	-	1	1375_1377	c.1239_1241GCC>AAA	c.(1237-1242)TTGCCT>TTAAAT	p.P414N	SEPT4_uc010wnx.1_5'Flank|SEPT4_uc010wny.1_5'Flank	NM_001038704	NP_001033793	Q8NEP4	CQ047_HUMAN	hypothetical protein LOC284083	414										breast(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GGACCGAGGAGGCAAGGGCCTAG	0.527		NA											24	79					0	0	0	0
USP32	84669	broad.mit.edu	37	17	58258936	58258936	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:58258936T>A	uc002iyo.1	-	32	4583	c.4297A>T	c.(4297-4299)AAT>TAT	p.N1433Y	USP32_uc002iyn.1_Missense_Mutation_p.N1103Y	NM_032582	NP_115971	Q8NFA0	UBP32_HUMAN	ubiquitin specific protease 32	1433					protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|breast(2)|large_intestine(1)	5	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)			CCAGCCCCATTTTCTTTGCTG	0.552		NA											17	55					0	0	0	0
ACE	1636	broad.mit.edu	37	17	61557822	61557822	+	Silent	SNP	C	C	T	rs4302	byFrequency	TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:61557822C>T	uc002jau.1	+	5	802	c.780C>T	c.(778-780)CGC>CGT	p.R260R	ACE_uc010wpi.1_Silent_p.R260R|ACE_uc010ddu.1_Silent_p.R77R	NM_000789	NP_000780	P12821	ACE_HUMAN	angiotensin I converting enzyme 1 isoform 1	260	Extracellular (Potential).|Peptidase M2 1.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	TCGTCCGCCGCGCACTGCATC	0.607		NA											31	65					0	0	0	0
TEX2	55852	broad.mit.edu	37	17	62291328	62291328	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:62291328C>A	uc002jec.2	-	2	423	c.250G>T	c.(250-252)GAC>TAC	p.D84Y	TEX2_uc002jed.2_Missense_Mutation_p.D84Y|TEX2_uc002jee.2_Missense_Mutation_p.D84Y	NM_018469	NP_060939	Q8IWB9	TEX2_HUMAN	testis expressed sequence 2	84					signal transduction|sphingolipid metabolic process	integral to membrane				ovary(1)	1			BRCA - Breast invasive adenocarcinoma(8;1.33e-10)	READ - Rectum adenocarcinoma(1115;0.0689)		CCGGCGGGGTCATGGCCAACT	0.562		NA											97	160					1.26e-39	1.95e-39	1	0
PITPNC1	26207	broad.mit.edu	37	17	65628289	65628289	+	Nonsense_Mutation	SNP	A	A	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:65628289A>T	uc002jgc.2	+	6	744	c.397A>T	c.(397-399)AGA>TGA	p.R133*	PITPNC1_uc002jgb.2_Nonsense_Mutation_p.R133*	NM_012417	NP_036549	Q9UKF7	PITC1_HUMAN	phosphatidylinositol transfer protein,	133					signal transduction	cytoplasm	lipid binding|phosphatidylinositol transporter activity|protein binding			skin(1)	1	all_cancers(12;3.03e-10)		BRCA - Breast invasive adenocarcinoma(8;2.08e-08)|Colorectal(3;0.198)			AGACGTGGAGAGAGAAGTTTG	0.428		NA											22	32					0	0	0	0
NOL11	25926	broad.mit.edu	37	17	65722658	65722658	+	Silent	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:65722658G>A	uc002jgd.1	+	7	750	c.747G>A	c.(745-747)CTG>CTA	p.L249L	NOL11_uc010wql.1_Silent_p.L67L|NOL11_uc010deu.1_5'UTR	NM_015462	NP_056277	Q9H8H0	NOL11_HUMAN	nucleolar protein 11	249						nucleolus					0	all_cancers(12;1.54e-10)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0518)|COAD - Colon adenocarcinoma(4;0.0977)|LUSC - Lung squamous cell carcinoma(166;0.24)			TTAAATCACTGCTGCTCAAGG	0.458		NA											33	42					0	0	0	0
ENOSF1	55556	broad.mit.edu	37	18	677394	677394	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr18:677394G>A	uc002kku.3	-	14	1174	c.1099C>T	c.(1099-1101)CAC>TAC	p.H367Y	ENOSF1_uc002kkt.3_Missense_Mutation_p.H285Y|ENOSF1_uc010dke.2_RNA|ENOSF1_uc010dkf.2_Missense_Mutation_p.H374Y|ENOSF1_uc002kkv.3_Missense_Mutation_p.H354Y|ENOSF1_uc002kkw.3_Missense_Mutation_p.H186Y|ENOSF1_uc002kkx.3_Missense_Mutation_p.H291Y	NM_017512	NP_059982	Q7L5Y1	ENOF1_HUMAN	enolase superfamily 1 isoform rTS beta	367					cellular amino acid catabolic process	mitochondrion	isomerase activity|metal ion binding			ovary(1)	1						ATAATCAGGTGCTGCACCAGT	0.433		NA											6	129					0	0	0	0
EPB41L3	23136	broad.mit.edu	37	18	5397201	5397201	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr18:5397201C>A	uc002kmt.1	-	18	2783	c.2697G>T	c.(2695-2697)GAG>GAT	p.E899D	EPB41L3_uc010wzh.1_Missense_Mutation_p.E730D|EPB41L3_uc002kmu.1_Missense_Mutation_p.E677D|EPB41L3_uc010dkq.1_Missense_Mutation_p.E568D|EPB41L3_uc002kms.1_Missense_Mutation_p.E134D|EPB41L3_uc010wze.1_Missense_Mutation_p.E204D|EPB41L3_uc010wzf.1_Missense_Mutation_p.E196D|EPB41L3_uc010wzg.1_Missense_Mutation_p.E171D|EPB41L3_uc010dkr.2_Missense_Mutation_p.E291D	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	899	Carboxyl-terminal (CTD).				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						CTTTAGCCCCCTCCGTCAAGG	0.602		NA											175	53					2.61e-80	4.1e-80	1	0
PTPRM	5797	broad.mit.edu	37	18	7888335	7888335	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr18:7888335C>A	uc002knn.3	+	3	931	c.428C>A	c.(427-429)GCA>GAA	p.A143E	PTPRM_uc010dkv.2_Missense_Mutation_p.A143E	NM_002845	NP_002836	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	143	MAM.|Extracellular (Potential).				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			lung(3)|ovary(2)|central_nervous_system(1)	6		Colorectal(10;0.234)				TGGAACAGGGCAGAACTGGCC	0.403		NA											7	145					5.49e-09	6.85e-09	1	0
PTPRM	5797	broad.mit.edu	37	18	8113617	8113617	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr18:8113617G>T	uc002knn.3	+	12	2493	c.1990G>T	c.(1990-1992)GAA>TAA	p.E664*	PTPRM_uc010dkv.2_Nonsense_Mutation_p.E664*|PTPRM_uc010wzl.1_Nonsense_Mutation_p.E451*	NM_002845	NP_002836	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	664	Fibronectin type-III 4.|Extracellular (Potential).				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			lung(3)|ovary(2)|central_nervous_system(1)	6		Colorectal(10;0.234)				CTTTGCTGCAGAATTTCCTGC	0.428		NA											125	37					2.6e-83	4.1e-83	1	0
KIAA0802	23255	broad.mit.edu	37	18	8786039	8786039	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr18:8786039G>A	uc002knr.2	+	7	1979	c.1837G>A	c.(1837-1839)GGG>AGG	p.G613R	KIAA0802_uc002knq.2_Missense_Mutation_p.G613R|KIAA0802_uc010dkw.1_Missense_Mutation_p.G451R	NM_015210	NP_056025	Q9Y4B5	CC165_HUMAN	hypothetical protein LOC23255	964											0						CCGCGCAGACGGGGACACCGG	0.726		NA											17	3					0	0	0	0
GNAL	2774	broad.mit.edu	37	18	11868555	11868555	+	Silent	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr18:11868555C>T	uc010dkz.2	+	10	939	c.693C>T	c.(691-693)ATC>ATT	p.I231I	GNAL_uc002kqc.2_Silent_p.I308I|GNAL_uc002kqd.2_Silent_p.I231I|GNAL_uc010wzt.1_Silent_p.I24I	NM_001142339	NP_001135811	P38405	GNAL_HUMAN	guanine nucleotide binding protein (G protein),	231					activation of adenylate cyclase activity by dopamine receptor signaling pathway|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception of smell|synaptic transmission	heterotrimeric G-protein complex	adenylate cyclase activity|G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			ovary(1)	1						TCACAGCTATCATTTACGTCG	0.463		NA											11	223					0	0	0	0
POTEC	388468	broad.mit.edu	37	18	14542920	14542920	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr18:14542920C>T	uc010dln.2	-	1	680	c.226G>A	c.(226-228)GGC>AGC	p.G76S	POTEC_uc010xaj.1_RNA	NM_001137671	NP_001131143	B2RU33	POTEC_HUMAN	ANKRD26-like family B, member 2	76										skin(3)	3						TTGCTCGTGCCGCTCCCCCTG	0.572		NA											14	402					0	0	0	0
KIAA1632	57724	broad.mit.edu	37	18	43492360	43492360	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr18:43492360C>A	uc002lbm.2	-	22	3978	c.3878G>T	c.(3877-3879)CGC>CTC	p.R1293L	KIAA1632_uc002lbo.1_Missense_Mutation_p.R1293L|KIAA1632_uc010xcq.1_5'UTR|KIAA1632_uc010xcr.1_RNA|KIAA1632_uc010xcs.1_RNA|KIAA1632_uc002lbn.2_Missense_Mutation_p.R168L	NM_020964	NP_066015	Q9HCE0	EPG5_HUMAN	hypothetical protein LOC57724	1293					autophagy						0						GTGGGCCCAGCGATAAATCAG	0.537		NA											6	75					1.07e-07	1.29e-07	1	0
DCC	1630	broad.mit.edu	37	18	50866223	50866223	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr18:50866223G>A	uc002lfe.1	+	15	2892	c.2305G>A	c.(2305-2307)GCT>ACT	p.A769T	DCC_uc010xdr.1_Missense_Mutation_p.A617T|DCC_uc010dpf.1_Missense_Mutation_p.A424T	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	769	Extracellular (Potential).|Fibronectin type-III 4.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		GAGCCCTTACGCTGAGACAGT	0.448		NA											10	31					0	0	0	0
CDH7	1005	broad.mit.edu	37	18	63547683	63547683	+	Silent	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr18:63547683C>A	uc002ljz.2	+	12	2236	c.1911C>A	c.(1909-1911)CCC>CCA	p.P637P	CDH7_uc002lkb.2_Silent_p.P637P	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	637	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				AAAAAGAGCCCCTTATTTTTG	0.458		NA											10	18					0.000442599	0.000483749	1	0
TSHZ1	10194	broad.mit.edu	37	18	72997606	72997606	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr18:72997606A>T	uc002lly.2	+	2	672	c.109A>T	c.(109-111)AGC>TGC	p.S37C		NM_005786	NP_005777	Q6ZSZ6	TSH1_HUMAN	teashirt family zinc finger 1	82	Ser-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Esophageal squamous(42;0.129)|Prostate(75;0.142)|Melanoma(33;0.211)		Colorectal(1;0.000501)|READ - Rectum adenocarcinoma(2;0.00226)|BRCA - Breast invasive adenocarcinoma(31;0.246)		CAGTGAGAGCAGCGACCAGCT	0.597		NA											9	10					0	0	0	0
ANKRD24	170961	broad.mit.edu	37	19	4216937	4216937	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:4216937G>T	uc010dtt.1	+	18	2056	c.1780G>T	c.(1780-1782)GCC>TCC	p.A594S	ANKRD24_uc002lzs.2_Missense_Mutation_p.A565S|ANKRD24_uc002lzt.2_Missense_Mutation_p.A566S	NM_133475	NP_597732	Q8TF21	ANR24_HUMAN	ankyrin repeat domain 24	594											0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0233)|STAD - Stomach adenocarcinoma(1328;0.181)		GGCCACAGGAGCCAAGGTCAC	0.562		NA											3	11					0.004672	0.00493652	1	0
MUC16	94025	broad.mit.edu	37	19	9074423	9074423	+	Silent	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:9074423G>T	uc002mkp.2	-	3	13227	c.13023C>A	c.(13021-13023)ACC>ACA	p.T4341T		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	4343	Thr-rich.|Extracellular (Potential).|Ser-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTTGTGTCTTGGTGACATGAG	0.483		NA											4	26					1.07e-07	1.29e-07	1	0
CDC37	11140	broad.mit.edu	37	19	10505718	10505718	+	Silent	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:10505718C>A	uc002mof.1	-	5	821	c.705G>T	c.(703-705)CGG>CGT	p.R235R	CDC37_uc002moe.1_Silent_p.R190R|CDC37_uc010dxf.1_Silent_p.R72R|CDC37_uc002mog.1_Intron|CDC37_uc002moh.2_Silent_p.R235R	NM_007065	NP_008996	Q16543	CDC37_HUMAN	cell division cycle 37 protein	235					protein targeting|regulation of cyclin-dependent protein kinase activity|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway		unfolded protein binding				0			OV - Ovarian serous cystadenocarcinoma(20;4.65e-10)|Epithelial(33;6.48e-07)|all cancers(31;2.31e-06)	GBM - Glioblastoma multiforme(1328;0.0318)		TGAAGAACTGCCGGAAGCAGG	0.587		NA											78	22					4.98e-18	6.98e-18	1	0
ZNF878	729747	broad.mit.edu	37	19	12154763	12154763	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:12154763C>G	uc002mta.1	-	5	1594	c.1594G>C	c.(1594-1596)GGG>CGG	p.G532R		NM_001080404	NP_001073873	C9JN71	ZN878_HUMAN	zinc finger protein 878	485	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0						AAGGCTTTCCCACACTGTTTA	0.383		NA											49	13					0	0	0	0
ZNF709	163051	broad.mit.edu	37	19	12577309	12577309	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:12577309A>C	uc002mtv.3	-	3	316	c.155T>G	c.(154-156)ATT>AGT	p.I52S	ZNF709_uc002mtw.3_Missense_Mutation_p.I20S|ZNF709_uc002mtx.3_Missense_Mutation_p.I52S	NM_152601	NP_689814	Q8N972	ZN709_HUMAN	zinc finger protein 709 isoform a	52	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GTGATCTTCAATGTTCTTCTC	0.338		NA											7	113					0	0	0	0
WIZ	58525	broad.mit.edu	37	19	15537872	15537872	+	Silent	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:15537872C>A	uc002nbc.2	-	4	1547	c.1524G>T	c.(1522-1524)CCG>CCT	p.P508P	WIZ_uc002nba.3_Silent_p.P375P|WIZ_uc002nbb.3_Silent_p.P334P	NM_021241	NP_067064	O95785	WIZ_HUMAN	widely-interspaced zinc finger motifs	1191						nucleus	zinc ion binding				0						GAAGGGCCCCCGGCAGCATCT	0.607		NA											75	22					5.02e-34	7.69e-34	1	0
PIK3R2	5296	broad.mit.edu	37	19	18271316	18271316	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:18271316C>T	uc002nia.1	+	3	870	c.358C>T	c.(358-360)CCA>TCA	p.P120S	PIK3R2_uc002nib.1_RNA|PIK3R2_uc010ebi.1_RNA	NM_005027	NP_005018	O00459	P85B_HUMAN	phosphoinositide-3-kinase, regulatory subunit 2	120	Rho-GAP.				fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|negative regulation of anti-apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|T cell costimulation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	GTPase activator activity|phosphatidylinositol 3-kinase regulator activity|protein binding			lung(2)|stomach(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|pancreas(1)	6						GCAGTTCTCCCCACCTGATGT	0.577		NA											29	34					0	0	0	0
ZNF737	100129842	broad.mit.edu	37	19	20727787	20727787	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:20727787A>G	uc002npa.2	-	4	1402	c.1222T>C	c.(1222-1224)TAC>CAC	p.Y408H		NM_001159293	NP_001152765	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	408					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						GAAGAGGAGTACTTAAAGGCT	0.428		NA											21	43					0	0	0	0
MLL4	9757	broad.mit.edu	37	19	36212275	36212275	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:36212275G>A	uc010eei.2	+	3	2026	c.2026G>A	c.(2026-2028)GCC>ACC	p.A676T		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	676	Pro-rich.				chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GGCTCCTGAAGCCCCTGAGCC	0.642		NA											7	7					0	0	0	0
ZNF568	374900	broad.mit.edu	37	19	37440567	37440567	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:37440567C>A	uc002ofc.2	+	7	1027	c.512C>A	c.(511-513)TCA>TAA	p.S171*	ZNF568_uc010efg.2_Intron|ZNF568_uc010xtn.1_Intron|ZNF568_uc002ofd.2_Nonsense_Mutation_p.S95*|ZNF568_uc010efe.2_Nonsense_Mutation_p.S95*|ZNF568_uc010eff.1_Intron	NM_198539	NP_940941	Q3ZCX4	ZN568_HUMAN	zinc finger protein 568	171					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			ATTGTTACTTCAAGACAAAGC	0.338		NA											8	93					0.000157383	0.000174701	1	0
GGN	199720	broad.mit.edu	37	19	38876144	38876144	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:38876144G>T	uc002oij.1	-	3	1893	c.1758C>A	c.(1756-1758)TTC>TTA	p.F586L	GGN_uc002oik.1_Intron|GGN_uc010efy.1_Intron	NM_152657	NP_689870	Q86UU5	GGN_HUMAN	gametogenetin	586	Interactions with ZNF403/GGNBP2 and OAZ3 (By similarity).				cell differentiation|multicellular organismal development|spermatogenesis						0	all_cancers(60;3.4e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			TAAGCACCTGGAAGGGCAGCC	0.667		NA											15	27					8.6e-14	1.16e-13	1	0
FAM98C	147965	broad.mit.edu	37	19	38899416	38899416	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:38899416G>T	uc002oin.1	+	8	963	c.944G>T	c.(943-945)CGG>CTG	p.R315L	FAM98C_uc002oio.1_Missense_Mutation_p.R233L|FAM98C_uc010xtz.1_Silent_p.P181P	NM_174905	NP_777565	Q17RN3	FA98C_HUMAN	hypothetical protein LOC147965	315										skin(1)	1	all_cancers(60;3.95e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			GTTCCAGACCGGGGGGGCCGC	0.562		NA											24	69					9.86e-18	1.38e-17	1	0
NCCRP1	342897	broad.mit.edu	37	19	39691333	39691333	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:39691333G>C	uc002okq.1	+	6	784	c.765G>C	c.(763-765)GAG>GAC	p.E255D		NM_001001414	NP_001001414	Q6ZVX7	NCRP1_HUMAN	non-specific cytotoxic cell receptor protein 1	255	FBA.				protein catabolic process					ovary(1)	1						ACCGCATGGAGCCTGGTGGGC	0.632		NA											121	196					0	0	0	0
PRX	57716	broad.mit.edu	37	19	40909731	40909731	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:40909731C>G	uc002onr.2	-	5	335	c.66G>C	c.(64-66)GAG>GAC	p.E22D	PRX_uc002onq.2_5'UTR|PRX_uc002ons.2_Missense_Mutation_p.E22D	NM_181882	NP_870998	Q9BXM0	PRAX_HUMAN	periaxin isoform 2	22	PDZ.				axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			ovary(2)	2			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GCGCCTCCGTCTCCACGATAA	0.692		NA											6	15					0	0	0	0
TGFB1	7040	broad.mit.edu	37	19	41854358	41854358	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:41854358T>C	uc002oqh.1	-	2	1225	c.358A>G	c.(358-360)ATC>GTC	p.I120V	CYP2F1_uc010xvw.1_Intron|TMEM91_uc002oqi.2_5'Flank	NM_000660	NP_000651	P01137	TGFB1_HUMAN	transforming growth factor, beta 1 precursor	120					active induction of host immune response by virus|ATP biosynthetic process|cell cycle arrest|cell growth|cell-cell junction organization|chondrocyte differentiation|connective tissue replacement involved in inflammatory response wound healing|epidermal growth factor receptor signaling pathway|evasion of host defenses by virus|hemopoietic progenitor cell differentiation|induction of apoptosis|lymph node development|mitotic cell cycle G1/S transition checkpoint|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of cell-cell adhesion|negative regulation of DNA replication|negative regulation of epithelial cell proliferation|negative regulation of fat cell differentiation|negative regulation of macrophage cytokine production|negative regulation of mitotic cell cycle|negative regulation of protein phosphorylation|ossification involved in bone remodeling|pathway-restricted SMAD protein phosphorylation|platelet activation|platelet degranulation|positive regulation of blood vessel endothelial cell migration|positive regulation of bone mineralization|positive regulation of cell division|positive regulation of chemotaxis|positive regulation of collagen biosynthetic process|positive regulation of epithelial to mesenchymal transition|positive regulation of fibroblast migration|positive regulation of interleukin-17 production|positive regulation of isotype switching to IgA isotypes|positive regulation of MAP kinase activity|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of protein dephosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of protein secretion|positive regulation of SMAD protein import into nucleus|protein export from nucleus|protein import into nucleus, translocation|receptor catabolic process|regulation of DNA binding|regulation of striated muscle tissue development|regulation of transforming growth factor beta receptor signaling pathway|response to cholesterol|response to estradiol stimulus|response to progesterone stimulus|salivary gland morphogenesis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway|viral infectious cycle	extracellular space|Golgi lumen|nucleus|platelet alpha granule lumen|proteinaceous extracellular matrix	growth factor activity|type II transforming growth factor beta receptor binding				0					Hyaluronidase(DB00070)	TTGTCATAGATTTCTAGCAGG	0.527		NA											45	68					0	0	0	0
CEACAM7	1087	broad.mit.edu	37	19	42187790	42187790	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:42187790A>T	uc002ori.1	-	3	634	c.632T>A	c.(631-633)ATA>AAA	p.I211K	CEACAM7_uc010ehx.2_Missense_Mutation_p.I211K|CEACAM7_uc010ehy.1_Intron	NM_006890	NP_008821	Q14002	CEAM7_HUMAN	carcinoembryonic antigen-related cell adhesion	211	Ig-like C2-type.					anchored to membrane|integral to membrane|plasma membrane				ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(3;0.0027)|all cancers(3;0.00979)|Epithelial(262;0.0366)		ATAGGGTCCTATGTCATTCTT	0.542		NA											93	131					0	0	0	0
CEACAM5	1048	broad.mit.edu	37	19	42224051	42224051	+	Silent	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:42224051C>T	uc002ork.2	+	7	1816	c.1695C>T	c.(1693-1695)GAC>GAT	p.D565D	CEACAM5_uc002orj.1_Silent_p.D564D|CEACAM5_uc002orl.2_Silent_p.D565D	NM_004363	NP_004354	P06731	CEAM5_HUMAN	carcinoembryonic antigen-related cell adhesion	565	Ig-like 6.					anchored to membrane|basolateral plasma membrane|integral to plasma membrane				skin(2)	2				OV - Ovarian serous cystadenocarcinoma(3;0.00278)|all cancers(3;0.00625)|Epithelial(262;0.0379)|GBM - Glioblastoma multiforme(1328;0.142)		CAAGAAATGACGCAAGAGCCT	0.517		NA											99	125					0	0	0	0
RELB	5971	broad.mit.edu	37	19	45540703	45540703	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:45540703C>A	uc002paj.1	+	13	1521	c.1395C>A	c.(1393-1395)GAC>GAA	p.D465E	SFRS16_uc002pak.2_5'Flank|SFRS16_uc002pal.2_5'Flank|SFRS16_uc010xxh.1_5'Flank|SFRS16_uc002pam.2_5'Flank|SFRS16_uc002pan.1_5'Flank	NM_006509	NP_006500	Q01201	RELB_HUMAN	reticuloendotheliosis viral oncogene homolog B	465						nucleus	protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)	1		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00986)		CAGACCCTGACTTCTTCTCTG	0.632		NA											41	193					5.45e-19	7.77e-19	1	0
SFRS16	11129	broad.mit.edu	37	19	45570821	45570821	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:45570821G>T	uc002pak.2	+	14	1734	c.1636G>T	c.(1636-1638)GCG>TCG	p.A546S	SFRS16_uc002pal.2_RNA|SFRS16_uc010xxh.1_Missense_Mutation_p.A484S|SFRS16_uc002pam.2_Missense_Mutation_p.A546S	NM_007056	NP_008987	Q8N2M8	CLASR_HUMAN	splicing factor, arginine/serine-rich 16	546	Arg-rich.				mRNA processing|RNA splicing	nucleus					0		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		CAGGCCGGCCGCGTCCCCTGC	0.438		NA											14	13					6.32e-08	7.69e-08	1	0
CCDC8	83987	broad.mit.edu	37	19	46914604	46914604	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:46914604C>T	uc002pep.2	-	1	2316	c.1464G>A	c.(1462-1464)TGG>TGA	p.W488*		NM_032040	NP_114429	Q9H0W5	CCDC8_HUMAN	coiled-coil domain containing 8	488						plasma membrane				ovary(3)	3				OV - Ovarian serous cystadenocarcinoma(262;4.66e-05)|all cancers(93;0.000582)|Epithelial(262;0.00428)|GBM - Glioblastoma multiforme(486;0.0421)		GCTTGCAAAACCACGAAAAGC	0.622		NA											37	57					0	0	0	0
GYS1	2997	broad.mit.edu	37	19	49488819	49488819	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:49488819C>A	uc002plp.2	-	5	963	c.722G>T	c.(721-723)CGA>CTA	p.R241L	GYS1_uc010xzy.1_Intron|GYS1_uc010emm.2_Missense_Mutation_p.R177L|GYS1_uc010xzz.1_Missense_Mutation_p.R161L|GYS1_uc010yaa.1_RNA	NM_002103	NP_002094	P13807	GYS1_HUMAN	glycogen synthase 1 (muscle) isoform 1	241					glucose metabolic process|glycogen biosynthetic process	cytosol	glycogen (starch) synthase activity|protein binding			ovary(2)	2		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;8.64e-05)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000164)|all cancers(93;0.000226)|GBM - Glioblastoma multiforme(486;0.00561)|Epithelial(262;0.0286)		CATGCAGTATCGGTGGTAGAT	0.522		NA											26	56					4.88e-14	6.6e-14	1	0
PRR12	57479	broad.mit.edu	37	19	50123642	50123642	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:50123642G>T	uc002poo.3	+	10	5531	c.5531G>T	c.(5530-5532)AGG>ATG	p.R1844M		NM_020719	NP_065770	Q9ULL5	PRR12_HUMAN	proline rich 12	1023							DNA binding			central_nervous_system(1)|pancreas(1)	2		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		CTCAAAACCAGGGCGATGCGG	0.507		NA											3	16					0.004672	0.00493652	1	0
CPT1C	126129	broad.mit.edu	37	19	50204810	50204810	+	Silent	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:50204810C>A	uc002ppj.2	+	6	817	c.612C>A	c.(610-612)GTC>GTA	p.V204V	CPT1C_uc002ppl.3_Silent_p.V170V|CPT1C_uc002ppi.2_Silent_p.V121V|CPT1C_uc002ppk.2_Silent_p.V204V|CPT1C_uc010eng.2_Silent_p.V204V|CPT1C_uc010enh.2_Silent_p.V204V|CPT1C_uc010ybc.1_Silent_p.V42V	NM_152359	NP_689572	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C isoform 2	204	Cytoplasmic (Potential).				fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		GGACCGCGGTCCTGGCGCAGG	0.577		NA											27	31					2.13e-12	2.82e-12	1	0
AP2A1	160	broad.mit.edu	37	19	50305113	50305113	+	Silent	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:50305113C>T	uc002ppn.2	+	14	2131	c.1920C>T	c.(1918-1920)ATC>ATT	p.I640I	AP2A1_uc010enj.1_RNA|AP2A1_uc002ppo.2_Silent_p.I640I|AP2A1_uc002ppp.1_Missense_Mutation_p.S11L	NM_014203	NP_055018	O95782	AP2A1_HUMAN	adaptor-related protein complex 2, alpha 1	640					axon guidance|endocytosis|epidermal growth factor receptor signaling pathway|Golgi to endosome transport|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|viral reproduction	AP-2 adaptor complex|clathrin coat of trans-Golgi network vesicle|cytosol	protein binding|protein transporter activity			ovary(2)	2		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.0023)|GBM - Glioblastoma multiforme(134;0.0157)		GCAACGACATCAACGGGGGCA	0.716		NA											6	4					0	0	0	0
NUP62	23636	broad.mit.edu	37	19	50412135	50412135	+	Silent	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:50412135C>A	uc002pqx.2	-	2	1034	c.930G>T	c.(928-930)GTG>GTT	p.V310V	IL4I1_uc002pqv.1_Intron|IL4I1_uc010eno.1_Intron|IL4I1_uc002pqw.1_Intron|IL4I1_uc002pqu.1_Intron|NUP62_uc002pqy.2_Silent_p.V310V|NUP62_uc002pqz.2_Silent_p.V310V|NUP62_uc002pra.2_Silent_p.V310V|NUP62_uc002prb.2_Silent_p.V310V|NUP62_uc002prc.2_Intron	NM_153719	NP_714941	P37198	NUP62_HUMAN	nucleoporin 62kDa	310	Ala-rich.				carbohydrate metabolic process|cell death|cell surface receptor linked signaling pathway|glucose transport|hormone-mediated signaling pathway|mRNA transport|negative regulation of apoptosis|negative regulation of cell proliferation|nucleocytoplasmic transport|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription, DNA-dependent|protein transport|regulation of glucose transport|transcription, DNA-dependent|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleocytoplasmic shuttling complex|ribonucleoprotein complex|spindle pole	chromatin binding|protein serine/threonine kinase activity|receptor signaling complex scaffold activity|SH2 domain binding|structural constituent of nuclear pore|thyroid hormone receptor binding|ubiquitin binding				0		all_lung(116;1.47e-05)|all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00242)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		GTGGAGCGGTCACGGCAGCTG	0.527		NA											25	54					4.23e-11	5.49e-11	1	0
SIGLEC9	27180	broad.mit.edu	37	19	51633327	51633327	+	Silent	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:51633327C>A	uc002pvu.2	+	7	1450	c.1383C>A	c.(1381-1383)ATC>ATA	p.I461I	SIGLEC9_uc010yct.1_Intron	NM_014441	NP_055256	Q9Y336	SIGL9_HUMAN	sialic acid binding Ig-like lectin 9 precursor	461	Cytoplasmic (Potential).				cell adhesion|cell surface receptor linked signaling pathway	integral to plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.000826)|OV - Ovarian serous cystadenocarcinoma(262;0.00295)		AGATCAAGATCCACAGATGAG	0.542		NA											22	50					1.28e-07	1.54e-07	1	0
ZNF649	65251	broad.mit.edu	37	19	52394076	52394076	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:52394076G>A	uc002pxy.2	-	5	1581	c.1313C>T	c.(1312-1314)GCT>GTT	p.A438V	ZNF577_uc010ydd.1_5'Flank|ZNF577_uc002pxx.3_5'Flank|ZNF577_uc002pxv.2_5'Flank|ZNF577_uc002pxw.2_5'Flank|ZNF577_uc010yde.1_5'Flank|ZNF577_uc010ydf.1_Intron	NM_023074	NP_075562	Q9BS31	ZN649_HUMAN	zinc finger protein 649	438	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00152)|OV - Ovarian serous cystadenocarcinoma(262;0.0185)		ATAGAAGTAAGCTTTCTCACA	0.448		NA											99	195					0	0	0	0
ZNF615	284370	broad.mit.edu	37	19	52496176	52496176	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:52496176G>A	uc002pye.1	-	6	2445	c.2153C>T	c.(2152-2154)GCG>GTG	p.A718V	ZNF615_uc002pyf.1_Missense_Mutation_p.A729V|ZNF615_uc002pyg.1_Missense_Mutation_p.A610V|ZNF615_uc002pyh.1_Missense_Mutation_p.A729V|ZNF615_uc010epi.1_Missense_Mutation_p.A725V|ZNF615_uc010ydg.1_Missense_Mutation_p.A723V	NM_198480	NP_940882	Q8N8J6	ZN615_HUMAN	zinc finger protein 615	718	C2H2-type 19.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00142)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		AGACAAGTGCGCAAAAGCTTT	0.438		NA											76	103					0	0	0	0
ZNF528	84436	broad.mit.edu	37	19	52919907	52919907	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:52919907G>T	uc002pzh.2	+	7	2228	c.1802G>T	c.(1801-1803)GGA>GTA	p.G601V	ZNF528_uc002pzi.2_Missense_Mutation_p.G368V	NM_032423	NP_115799	Q3MIS6	ZN528_HUMAN	zinc finger protein 528	601					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(134;0.00249)|OV - Ovarian serous cystadenocarcinoma(262;0.00817)		ATTCACATTGGAGAGAAACCT	0.418		NA											34	62					9.81e-26	1.47e-25	1	0
ZNF415	55786	broad.mit.edu	37	19	53612438	53612438	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:53612438A>G	uc002qax.2	-	7	1353	c.1004T>C	c.(1003-1005)CTT>CCT	p.L335P	ZNF415_uc002qat.2_Missense_Mutation_p.L299P|ZNF415_uc002qaw.2_Missense_Mutation_p.L287P|ZNF415_uc010yds.1_Missense_Mutation_p.L287P|ZNF415_uc010ydt.1_Missense_Mutation_p.L287P|ZNF415_uc002qau.2_Missense_Mutation_p.L274P|ZNF415_uc002qav.2_Missense_Mutation_p.L299P|ZNF415_uc002qba.2_Missense_Mutation_p.L57P|ZNF415_uc002qay.2_Missense_Mutation_p.L274P|ZNF415_uc002qaz.2_Missense_Mutation_p.L335P	NR_028343		Q09FC8	ZN415_HUMAN	RecName: Full=Zinc finger protein 415;	335	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton|nucleolus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.0191)		ATGTAGTGCAAGGCATGAGTT	0.413		NA											11	75					0	0	0	0
NLRP12	91662	broad.mit.edu	37	19	54297343	54297343	+	Missense_Mutation	SNP	G	G	T	rs146786265	by1000genomes	TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:54297343G>T	uc002qch.3	-	10	3366	c.3146C>A	c.(3145-3147)GCG>GAG	p.A1049E	NLRP12_uc010eqw.2_Missense_Mutation_p.A275E|NLRP12_uc002qci.3_Missense_Mutation_p.A992E|NLRP12_uc002qcj.3_Missense_Mutation_p.A1050E|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_3'UTR	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	1049	LRR 8.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		TACTCGAAGCGCTGCCAACCT	0.463		NA											21	54					5.35e-11	6.91e-11	1	0
CACNG7	59284	broad.mit.edu	37	19	54418659	54418659	+	Silent	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:54418659C>A	uc002qcr.1	+	3	339	c.324C>A	c.(322-324)CTC>CTA	p.L108L	CACNG7_uc010era.1_Silent_p.L108L	NM_031896	NP_114102	P62955	CCG7_HUMAN	voltage-dependent calcium channel gamma-7	108	Helical; (Potential).				regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(1)	1	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0711)		TGGTCAGCCTCTTCCTCGTGT	0.607		NA											22	32					1.85e-09	2.33e-09	1	0
TMC4	147798	broad.mit.edu	37	19	54666867	54666867	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:54666867G>C	uc010erf.2	-	9	1453	c.1321C>G	c.(1321-1323)CTG>GTG	p.L441V	TMC4_uc002qdn.2_Missense_Mutation_p.L155V|TMC4_uc002qdo.2_Missense_Mutation_p.L435V	NM_001145303	NP_001138775	Q7Z404	TMC4_HUMAN	transmembrane channel-like 4 isoform 1	441	Helical; (Potential).					integral to membrane				pancreas(1)	1	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					AGGACCACCAGGGAGGCGAGG	0.577		NA											15	30					0	0	0	0
LAIR2	3904	broad.mit.edu	37	19	55019221	55019222	+	Nonsense_Mutation	DNP	GG	GG	TT			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:55019221_55019222GG>TT	uc002qgc.2	+	3	308_309	c.186_187GG>TT	c.(184-189)AGGGAG>AGTTAG	p.62_63RE>S*	LAIR2_uc002qga.1_RNA|LAIR2_uc002qgb.1_RNA|LAIR2_uc002qgd.2_Nonsense_Mutation_p.62_63RE>S*|LAIR2_uc010erl.2_Nonsense_Mutation_p.62_63RE>S*	NM_002288	NP_002279	Q6ISS4	LAIR2_HUMAN	leukocyte-associated immunoglobulin-like	62_63	Ig-like C2-type.					extracellular region	receptor activity			ovary(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0967)		GCCTGGAGAGGGAGGATAGAGC	0.53		NA											50	76					0	0	0	0
LILRA1	11024	broad.mit.edu	37	19	55106360	55106360	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:55106360G>T	uc002qgh.1	+	4	483	c.301G>T	c.(301-303)GGT>TGT	p.G101C	LILRA2_uc010yfg.1_Intron|LILRA1_uc010yfh.1_Missense_Mutation_p.G101C	NM_006863	NP_006854	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor,	101	Ig-like C2-type 1.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(193;0.0348)		CTGTTTCTACGGTAGCCACAC	0.607		NA											42	63					4.02e-15	5.51e-15	1	0
LILRB4	11006	broad.mit.edu	37	19	55177323	55177324	+	Missense_Mutation	DNP	TC	TC	AA			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:55177323_55177324TC>AA	uc002qgp.2	+	7	1177_1178	c.815_816TC>AA	c.(814-816)CTC>CAA	p.L272Q	LILRB4_uc002qgq.2_Missense_Mutation_p.L272Q|LILRB4_uc002qgr.2_Missense_Mutation_p.L313Q|LILRB4_uc010ert.2_Missense_Mutation_p.L313Q|LILRB4_uc010eru.2_Missense_Mutation_p.L301Q	NM_006847	NP_006838	Q8NHJ6	LIRB4_HUMAN	leukocyte immunoglobulin-like receptor,	272	Helical; (Potential).					integral to membrane|plasma membrane	antigen binding|receptor activity			ovary(3)	3				GBM - Glioblastoma multiforme(193;0.035)		Atcctgcttctctccctcctcc	0.431		NA											8	20					0	0	0	0
NLRP8	126205	broad.mit.edu	37	19	56487625	56487625	+	Silent	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:56487625G>T	uc002qmh.2	+	8	2903	c.2832G>T	c.(2830-2832)CTG>CTT	p.L944L	NLRP8_uc010etg.2_Silent_p.L925L	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	944	LRR 5.					cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		TGATCCTGCTGTGTGAGGCCC	0.463		NA											35	50					1.07e-22	1.58e-22	1	0
PEG3	5178	broad.mit.edu	37	19	57325220	57325220	+	Missense_Mutation	SNP	C	C	G	rs140891968		TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:57325220C>G	uc002qnu.2	-	7	4941	c.4590G>C	c.(4588-4590)ATG>ATC	p.M1530I	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.M1501I|PEG3_uc002qnv.2_Missense_Mutation_p.M1530I|PEG3_uc002qnw.2_Missense_Mutation_p.M1406I|PEG3_uc002qnx.2_Missense_Mutation_p.M1404I|PEG3_uc010etr.2_Missense_Mutation_p.M1530I	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	1530					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		CAAATATGATCATGCTGGCAT	0.478		NA											44	69					0	0	0	0
ZNF17	7565	broad.mit.edu	37	19	57931542	57931542	+	Silent	SNP	A	A	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:57931542A>C	uc002qoo.1	+	3	913	c.682A>C	c.(682-684)AGG>CGG	p.R228R	ZNF547_uc002qpm.3_Intron|ZNF17_uc002qop.1_Silent_p.R230R	NM_006959	NP_008890	P17021	ZNF17_HUMAN	zinc finger protein 17	228	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0234)|GBM - Glioblastoma multiforme(193;0.000426)|Lung(386;0.176)		CAAATTGTTTAGGTACAACTC	0.413		NA											5	91					0	0	0	0
PXDN	7837	broad.mit.edu	37	2	1652098	1652098	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:1652098G>T	uc002qxa.2	-	17	3518	c.3454C>A	c.(3454-3456)CTG>ATG	p.L1152M		NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	1152					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		GCCAGGTCCAGAGCCACCGTG	0.647		NA											24	42					1.38e-21	2.01e-21	1	0
PXDN	7837	broad.mit.edu	37	2	1652817	1652817	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:1652817G>A	uc002qxa.2	-	17	2799	c.2735C>T	c.(2734-2736)GCA>GTA	p.A912V		NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	912					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		CACGTTGGATGCGTCTATGTA	0.672		NA											18	22					0	0	0	0
PXDN	7837	broad.mit.edu	37	2	1668820	1668820	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:1668820G>C	uc002qxa.2	-	11	1382	c.1318C>G	c.(1318-1320)CAG>GAG	p.Q440E	PXDN_uc002qxb.1_Missense_Mutation_p.Q440E|PXDN_uc002qxc.1_Missense_Mutation_p.Q257E	NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	440	Ig-like C2-type 3.				extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		ACTCTGTCCTGAGGCGTCACA	0.532		NA											9	8					0	0	0	0
HPCAL1	3241	broad.mit.edu	37	2	10563138	10563138	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:10563138G>A	uc002raj.2	+	4	782	c.408G>A	c.(406-408)ATG>ATA	p.M136I	HPCAL1_uc002rak.2_Missense_Mutation_p.M136I|HPCAL1_uc002ral.2_Missense_Mutation_p.M136I|HPCAL1_uc010exe.2_RNA|HPCAL1_uc010exf.2_Missense_Mutation_p.M136I	NM_002149	NP_002140	P37235	HPCL1_HUMAN	hippocalcin-like 1	136							calcium ion binding			pancreas(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.214)		CGTCTGTGATGAAGATGCCGG	0.622		NA											11	36					0	0	0	0
NBAS	51594	broad.mit.edu	37	2	15415825	15415825	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:15415825T>A	uc002rcc.1	-	44	5533	c.5507A>T	c.(5506-5508)AAG>ATG	p.K1836M	NBAS_uc010exl.1_Missense_Mutation_p.K908M|NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	1836										ovary(2)|liver(1)|skin(1)	4						CTGTCCATCCTTTTCAGGGAT	0.433		NA											17	54					0	0	0	0
DNMT3A	1788	broad.mit.edu	37	2	25464448	25464448	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:25464448T>A	uc002rgc.2	-	17	2322	c.2065A>T	c.(2065-2067)AGC>TGC	p.S689C	DNMT3A_uc002rgd.2_Missense_Mutation_p.S689C|DNMT3A_uc010eyi.2_RNA|DNMT3A_uc002rgb.2_Missense_Mutation_p.S500C	NM_022552	NP_072046	Q9Y6K1	DNM3A_HUMAN	DNA cytosine methyltransferase 3 alpha isoform	689					regulation of gene expression by genetic imprinting	cytoplasm|euchromatin|nuclear matrix	DNA (cytosine-5-)-methyltransferase activity|DNA binding|metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(133)|lung(4)|ovary(3)	140	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGTGTGACGCTGCGGACGTCC	0.612		NA	Mis|F|N|S		AML								9	43					0	0	0	0
TRMT61B	55006	broad.mit.edu	37	2	29074027	29074027	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:29074027T>C	uc002rmm.2	-	5	1255	c.1223A>G	c.(1222-1224)AAA>AGA	p.K408R	TRMT61B_uc002rmn.2_Missense_Mutation_p.K408R|TRMT61B_uc010ezk.2_Intron	NM_017910	NP_060380	Q9BVS5	TR61B_HUMAN	tRNA methyltransferase 61 homolog B	408							tRNA (adenine-N1-)-methyltransferase activity				0						AGATTCTACTTTTTGAGCTAA	0.378		NA											7	39					0	0	0	0
BIRC6	57448	broad.mit.edu	37	2	32740755	32740755	+	Missense_Mutation	SNP	G	G	A	rs138598333	byFrequency	TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:32740755G>A	uc010ezu.2	+	55	11401	c.11267G>A	c.(11266-11268)CGC>CAC	p.R3756H		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	3756					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					ACTCAACAGCGCACAGCAATT	0.433		NA											11	47					0	0	0	0
TTC27	55622	broad.mit.edu	37	2	32859031	32859031	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:32859031C>G	uc002rom.2	+	3	586	c.355C>G	c.(355-357)CAG>GAG	p.Q119E	TTC27_uc010ymx.1_Missense_Mutation_p.Q69E	NM_017735	NP_060205	Q6P3X3	TTC27_HUMAN	tetratricopeptide repeat domain 27	119							protein binding			central_nervous_system(1)	1						CTTACACCCTCAGGACTTTTT	0.358		NA											23	64					0	0	0	0
LTBP1	4052	broad.mit.edu	37	2	33246136	33246136	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:33246136G>T	uc002ros.2	+	3	726	c.726G>T	c.(724-726)TGG>TGT	p.W242C		NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	242					negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				CTTCCTCGTGGGGCCCTCCTG	0.562		NA											65	83					6.17e-39	9.53e-39	1	0
C2orf86	51057	broad.mit.edu	37	2	63380060	63380060	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:63380060C>A	uc002sch.2	-	17	2625	c.2179G>T	c.(2179-2181)GGC>TGC	p.G727C	C2orf86_uc002sce.2_RNA|C2orf86_uc002scf.2_Missense_Mutation_p.G568C|C2orf86_uc010ypu.1_RNA|C2orf86_uc002scg.2_Missense_Mutation_p.G535C	NM_015910	NP_056994	O95876	FRITZ_HUMAN	hypothetical protein LOC51057 isoform 2	727					cilium morphogenesis|regulation of embryonic cell shape|regulation of protein localization|septin cytoskeleton organization	cilium axoneme|cytoplasm|cytoskeleton|plasma membrane					0						TGTTCTCTGCCGTCTTCTCTC	0.274		NA											10	29					1.05e-09	1.33e-09	1	0
SPRED2	200734	broad.mit.edu	37	2	65540979	65540979	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:65540979C>G	uc002sdr.3	-	6	1448	c.913G>C	c.(913-915)GAG>CAG	p.E305Q	SPRED2_uc010fcw.2_Missense_Mutation_p.E302Q	NM_181784	NP_861449	Q7Z698	SPRE2_HUMAN	sprouty-related protein with EVH-1 domain 2	305					inactivation of MAPK activity|multicellular organismal development	transport vesicle membrane	stem cell factor receptor binding			ovary(1)|lung(1)|central_nervous_system(1)	3						CGCGAGCGCTCTCCGTCCTCC	0.682		NA											20	94					0	0	0	0
SMYD5	10322	broad.mit.edu	37	2	73446061	73446061	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:73446061G>T	uc002siw.2	+	2	198	c.169G>T	c.(169-171)GCA>TCA	p.A57S	SMYD5_uc010yre.1_5'UTR	NM_006062	NP_006053	Q6GMV2	SMYD5_HUMAN	SMYD family member 5	57							metal ion binding				0						CCTGGTGGCTGCACAGTTTCT	0.557		NA											17	44					2.38e-13	3.17e-13	1	0
LOXL3	84695	broad.mit.edu	37	2	74763195	74763195	+	Silent	SNP	T	T	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:74763195T>A	uc002smp.1	-	7	1248	c.1176A>T	c.(1174-1176)ACA>ACT	p.T392T	LOXL3_uc002smo.1_Silent_p.T31T|LOXL3_uc010ffm.1_Silent_p.T392T|LOXL3_uc002smq.1_Silent_p.T247T|LOXL3_uc010ffn.1_Silent_p.T247T	NM_032603	NP_115992	P58215	LOXL3_HUMAN	lysyl oxidase-like 3 precursor	392	SRCR 3.					extracellular space|membrane	copper ion binding|protein-lysine 6-oxidase activity|scavenger receptor activity				0						AATCCTCAGCTGTGATGTTCT	0.567		NA											39	46					0	0	0	0
REG1A	5967	broad.mit.edu	37	2	79349979	79349979	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:79349979C>T	uc002snz.2	+	5	437	c.334C>T	c.(334-336)CAC>TAC	p.H112Y	REG1A_uc010ysd.1_Missense_Mutation_p.H112Y	NM_002909	NP_002900	P05451	REG1A_HUMAN	regenerating islet-derived 1 alpha precursor	112	C-type lectin.				positive regulation of cell proliferation	extracellular region	growth factor activity|sugar binding				0						CCGCCGCTGGCACTGGAGCAG	0.557		NA											34	120					0	0	0	0
PROM2	150696	broad.mit.edu	37	2	95952298	95952298	+	Silent	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:95952298C>A	uc002suh.1	+	17	2152	c.2019C>A	c.(2017-2019)GTC>GTA	p.V673V	PROM2_uc002sui.2_Silent_p.V673V|PROM2_uc002suj.2_Silent_p.V327V|PROM2_uc002suk.2_Silent_p.V673V|PROM2_uc002sul.2_Silent_p.V199V|PROM2_uc002sum.2_RNA	NM_144707	NP_653308	Q8N271	PROM2_HUMAN	prominin 2 precursor	673	Extracellular (Potential).					apical plasma membrane|basolateral plasma membrane|cilium membrane|integral to membrane|microvillus membrane				ovary(1)	1						AGGAGAAGGTCGTCCCCCAGC	0.612		NA											34	44					2.87e-16	3.98e-16	1	0
AFF3	3899	broad.mit.edu	37	2	100623731	100623731	+	Silent	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:100623731G>A	uc002tag.2	-	5	602	c.366C>T	c.(364-366)CCC>CCT	p.P122P	AFF3_uc002taf.2_Silent_p.P147P|AFF3_uc010fiq.1_Silent_p.P122P|AFF3_uc010yvr.1_Silent_p.P276P|AFF3_uc002tah.1_Silent_p.P147P|AFF3_uc010fir.1_Silent_p.P199P|AFF3_uc002tai.2_Silent_p.P44P	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	122					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						AGATAGACGAGGGCTGGTTCT	0.537		NA											41	58					0	0	0	0
CCDC138	165055	broad.mit.edu	37	2	109408221	109408221	+	Silent	SNP	G	G	A	rs36034137	byFrequency	TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:109408221G>A	uc002ten.1	+	4	417	c.357G>A	c.(355-357)TCG>TCA	p.S119S	CCDC138_uc002teo.1_Silent_p.S119S|CCDC138_uc002tep.1_5'UTR|CCDC138_uc010fjm.1_5'UTR	NM_144978	NP_659415	Q96M89	CC138_HUMAN	coiled-coil domain containing 138	119											0						TTAGTACCTCGAAAATAACCA	0.284		NA											18	101					0	0	0	0
DPP10	57628	broad.mit.edu	37	2	116598360	116598360	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:116598360C>G	uc002tla.1	+	25	2674	c.2217C>G	c.(2215-2217)ATC>ATG	p.I739M	DPP10_uc002tlb.1_Missense_Mutation_p.I689M|DPP10_uc002tlc.1_Missense_Mutation_p.I735M|DPP10_uc002tle.2_Missense_Mutation_p.I743M|DPP10_uc002tlf.1_Missense_Mutation_p.I732M	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	739	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						CAGAATTAATCAAGCACCTAA	0.343		NA											37	52					0	0	0	0
GLI2	2736	broad.mit.edu	37	2	121555035	121555035	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:121555035G>A	uc010flp.2	+	1	169	c.139G>A	c.(139-141)GCC>ACC	p.A47T	GLI2_uc010yyu.1_Missense_Mutation_p.A47T|GLI2_uc002tmp.1_Missense_Mutation_p.A47T|GLI2_uc010fln.1_RNA|GLI2_uc002tmq.1_5'UTR|GLI2_uc002tmr.1_5'UTR|GLI2_uc002tmt.3_5'UTR|GLI2_uc002tmu.3_5'UTR|GLI2_uc002tmv.1_Missense_Mutation_p.A47T|GLI2_uc010flo.1_5'UTR|GLI2_uc002tmw.1_Missense_Mutation_p.A47T	NM_005270	NP_005261	P10070	GLI2_HUMAN	GLI-Kruppel family member GLI2	47					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|lung(2)|breast(1)|central_nervous_system(1)|pancreas(1)	13	Renal(3;0.0496)	Prostate(154;0.0623)				AGCGGTAGCTGCCCAAGGAGG	0.572		NA											29	66					0	0	0	0
YSK4	80122	broad.mit.edu	37	2	135744037	135744037	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:135744037G>A	uc002tue.1	-	7	2436	c.2405C>T	c.(2404-2406)CCT>CTT	p.P802L	YSK4_uc002tuf.1_Intron|YSK4_uc010fnc.1_Intron|YSK4_uc010fnd.1_Missense_Mutation_p.P689L|YSK4_uc010zbg.1_Intron|YSK4_uc002tuh.3_Missense_Mutation_p.P530L|YSK4_uc002tui.3_Missense_Mutation_p.P819L	NM_025052	NP_079328	Q56UN5	YSK4_HUMAN	Yeast Sps1/Ste20-related kinase 4 isoform 1	802							ATP binding|protein serine/threonine kinase activity			stomach(2)|urinary_tract(1)|ovary(1)|breast(1)	5				BRCA - Breast invasive adenocarcinoma(221;0.112)		TGAGACAGGAGGGAATTCATT	0.388		NA											54	56					0	0	0	0
R3HDM1	23518	broad.mit.edu	37	2	136467633	136467633	+	Silent	SNP	A	A	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:136467633A>G	uc002tuo.2	+	22	2833	c.2463A>G	c.(2461-2463)GGA>GGG	p.G821G	R3HDM1_uc010fni.2_Silent_p.G820G|R3HDM1_uc002tup.2_Silent_p.G766G|R3HDM1_uc010zbh.1_Silent_p.G569G	NM_015361	NP_056176	Q15032	R3HD1_HUMAN	R3H domain containing 1	821							nucleic acid binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.127)		TTTCAGCTGGACCACCACCGC	0.443		NA									OREG0014997	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	40	73					0	0	0	0
LCT	3938	broad.mit.edu	37	2	136566979	136566979	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:136566979A>T	uc002tuu.1	-	8	2949	c.2938T>A	c.(2938-2940)TGG>AGG	p.W980R		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	980	3.|Extracellular (Potential).|4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)		ATCCGAGACCAGGAGATAGAG	0.498		NA											40	50					0	0	0	0
UPP2	151531	broad.mit.edu	37	2	158962720	158962720	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:158962720G>C	uc002tzp.2	+	2	366	c.172G>C	c.(172-174)GAT>CAT	p.D58H	UPP2_uc002tzo.2_Missense_Mutation_p.D115H	NM_173355	NP_775491	O95045	UPP2_HUMAN	uridine phosphorylase 2 isoform a	58					nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside salvage|uridine metabolic process	cytosol|type III intermediate filament	uridine phosphorylase activity				0						AATGTTTGGAGATGTAAAGGT	0.328		NA											15	27					0	0	0	0
BAZ2B	29994	broad.mit.edu	37	2	160257124	160257124	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:160257124G>A	uc002uao.2	-	17	3236	c.2884C>T	c.(2884-2886)CAG>TAG	p.Q962*	BAZ2B_uc002uap.2_Nonsense_Mutation_p.Q926*|BAZ2B_uc002uaq.1_Nonsense_Mutation_p.Q792*	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	962	Lys-rich.|Potential.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						AGAATTTGCTGAGCTCGAAGT	0.259		NA											11	26					0	0	0	0
FIGN	55137	broad.mit.edu	37	2	164466811	164466811	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:164466811C>A	uc002uck.1	-	3	1842	c.1531G>T	c.(1531-1533)GCG>TCG	p.A511S		NM_018086	NP_060556	Q5HY92	FIGN_HUMAN	fidgetin	511						nuclear matrix	ATP binding|nucleoside-triphosphatase activity			large_intestine(2)|ovary(1)|skin(1)	4						CCACTGAACGCGTCTGACCTC	0.532		NA											54	60					9.11e-22	1.33e-21	1	0
SCN3A	6328	broad.mit.edu	37	2	165956828	165956828	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:165956828C>A	uc002ucx.2	-	22	4442	c.3950G>T	c.(3949-3951)CGG>CTG	p.R1317L	SCN3A_uc002ucy.2_Missense_Mutation_p.R1268L|SCN3A_uc002ucz.2_Missense_Mutation_p.R1268L|SCN3A_uc002uda.1_Missense_Mutation_p.R1137L|SCN3A_uc002udb.1_Missense_Mutation_p.R1137L	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	1317	Helical; Voltage-sensor; Name=S4 of repeat III; (Potential).					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	GCCTTCAAACCGGGATAAGGC	0.403		NA											39	56					6.34e-27	9.58e-27	1	0
SCRN3	79634	broad.mit.edu	37	2	175287708	175287708	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:175287708T>A	uc002uiq.2	+	6	938	c.850T>A	c.(850-852)TCT>ACT	p.S284T	SCRN3_uc010zen.1_Missense_Mutation_p.S277T|SCRN3_uc010zeo.1_Missense_Mutation_p.S82T|SCRN3_uc002uis.2_Missense_Mutation_p.S26T	NM_024583	NP_078859	Q0VDG4	SCRN3_HUMAN	secernin 3	284					proteolysis		dipeptidase activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.229)			AAGCATGGTTTCTATTTTACC	0.408		NA											42	46					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179401131	179401131	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:179401131C>G	uc010zfg.1	-	306	92863	c.92639G>C	c.(92638-92640)CGA>CCA	p.R30880P	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R24575P|TTN_uc010zfi.1_Missense_Mutation_p.R24508P|TTN_uc010zfj.1_Missense_Mutation_p.R24383P	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	31807							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GACAGTTTCTCGAATTTCTTC	0.388		NA											23	61					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179412806	179412806	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:179412806C>T	uc010zfg.1	-	288	86067	c.85843G>A	c.(85843-85845)GAA>AAA	p.E28615K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E22310K|TTN_uc010zfi.1_Missense_Mutation_p.E22243K|TTN_uc010zfj.1_Missense_Mutation_p.E22118K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	29542							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACACGGAATTCATATTCAGTT	0.453		NA											93	88					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179439363	179439363	+	Silent	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:179439363G>T	uc010zfg.1	-	275	64016	c.63792C>A	c.(63790-63792)ACC>ACA	p.T21264T	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.T14959T|TTN_uc010zfi.1_Silent_p.T14892T|TTN_uc010zfj.1_Silent_p.T14767T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	22191							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTACCTGAGGGGTACCAGGAG	0.448		NA											18	87					3.52e-12	4.65e-12	1	0
TTN	7273	broad.mit.edu	37	2	179443986	179443986	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:179443986G>C	uc010zfg.1	-	269	60291	c.60067C>G	c.(60067-60069)CTA>GTA	p.L20023V	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.L13718V|TTN_uc010zfi.1_Missense_Mutation_p.L13651V|TTN_uc010zfj.1_Missense_Mutation_p.L13526V|uc002umv.1_Missense_Mutation_p.R71T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	20950							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCAGTTGCTAGAGGATCTTCC	0.438		NA											55	65					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179598401	179598401	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:179598401T>C	uc010zfg.1	-	50	12207	c.11983A>G	c.(11983-11985)ACG>GCG	p.T3995A	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.T656A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	4922							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.E3995*(1)		ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCCAGGCACGTGTATTTGCCT	0.383		NA											48	119					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179610817	179610817	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:179610817G>T	uc002unb.2	-	46	16534	c.16310C>A	c.(16309-16311)ACT>AAT	p.T5437N	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	8944							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AATTTTAAGAGTGTGACTTCC	0.418		NA											96	101					5.72e-57	8.95e-57	1	0
TTN	7273	broad.mit.edu	37	2	179613353	179613353	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:179613353C>T	uc002unb.2	-	46	13998	c.13774G>A	c.(13774-13776)GAA>AAA	p.E4592K	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTATCTAATTCTTGGAATTTC	0.318		NA											11	234					0	0	0	0
SSFA2	6744	broad.mit.edu	37	2	182779977	182779977	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:182779977C>T	uc002uoi.2	+	11	1932	c.1610C>T	c.(1609-1611)GCT>GTT	p.A537V	SSFA2_uc002uoh.2_Missense_Mutation_p.A537V|SSFA2_uc002uoj.2_Missense_Mutation_p.A537V|SSFA2_uc002uok.2_RNA|SSFA2_uc010zfo.1_Missense_Mutation_p.A384V|SSFA2_uc002uol.2_Missense_Mutation_p.A384V|SSFA2_uc002uom.2_Missense_Mutation_p.A5V	NM_001130445	NP_001123917	P28290	SSFA2_HUMAN	sperm specific antigen 2 isoform 1	537						cytoplasm|plasma membrane	actin binding			breast(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0856)			GGGAGTAGTGCTGATAGTTGT	0.423		NA											66	82					0	0	0	0
COL5A2	1290	broad.mit.edu	37	2	189918902	189918902	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:189918902C>A	uc002uqk.2	-	36	2703	c.2428G>T	c.(2428-2430)GGT>TGT	p.G810C	COL5A2_uc010frx.2_Missense_Mutation_p.G386C	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	810					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			CCAGTAGGACCTGCCGGACCT	0.393		NA											55	71					3.64e-18	5.12e-18	1	0
DNAH7	56171	broad.mit.edu	37	2	196825030	196825030	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:196825030T>C	uc002utj.3	-	18	2946	c.2845A>G	c.(2845-2847)ACT>GCT	p.T949A		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	949	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						CCTCGCATAGTTTGTGTTTTA	0.323		NA											11	157					0	0	0	0
CYP27A1	1593	broad.mit.edu	37	2	219677074	219677074	+	Silent	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:219677074G>T	uc002viz.3	+	3	1010	c.576G>T	c.(574-576)CTG>CTT	p.L192L		NM_000784	NP_000775	Q02318	CP27A_HUMAN	cytochrome P450, family 27, subfamily A,	192					bile acid biosynthetic process|xenobiotic metabolic process	mitochondrial matrix	cholestanetriol 26-monooxygenase activity|electron carrier activity|heme binding			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;9.48e-07)|all cancers(144;0.000171)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00981)	Cholecalciferol(DB00169)	TGGACCAGCTGCGGGCAGAGA	0.557		NA											11	173					1.09e-07	1.31e-07	1	0
SP140L	93349	broad.mit.edu	37	2	231248247	231248247	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:231248247G>T	uc010fxm.1	+	8	751	c.660G>T	c.(658-660)TGG>TGT	p.W220C	SP140L_uc010fxo.1_Missense_Mutation_p.W27C	NM_138402	NP_612411	Q9H930	LY10L_HUMAN	SP140 nuclear body protein-like	220						nucleus	DNA binding|metal ion binding			central_nervous_system(1)	1						GGCATGGCTGGAGCAGAATGG	0.358		NA											8	15					2.18e-05	2.47e-05	1	0
ECEL1	9427	broad.mit.edu	37	2	233349955	233349956	+	Missense_Mutation	DNP	AG	AG	TT			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:233349955_233349956AG>TT	uc002vsv.2	-	3	1013_1014	c.808_809CT>AA	c.(808-810)CTG>AAG	p.L270K	ECEL1_uc010fya.1_Missense_Mutation_p.L270K|ECEL1_uc010fyb.1_5'UTR	NM_004826	NP_004817	O95672	ECEL1_HUMAN	endothelin converting enzyme-like 1	270	Lumenal (Potential).				neuropeptide signaling pathway|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity			central_nervous_system(2)	2		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000771)|Lung(119;0.00213)|LUSC - Lung squamous cell carcinoma(224;0.00746)		CCTCTCTGGCAGGGTGAGCCCA	0.634		NA											15	5					0	0	0	0
KIF1A	547	broad.mit.edu	37	2	241661290	241661290	+	Silent	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr2:241661290C>T	uc002vzy.2	-	42	4520	c.4374G>A	c.(4372-4374)CTG>CTA	p.L1458L	KIF1A_uc010fzk.2_Silent_p.L1559L|KIF1A_uc002vzw.2_Silent_p.L119L|KIF1A_uc002vzx.2_Silent_p.L185L	NM_004321	NP_004312	Q12756	KIF1A_HUMAN	axonal transport of synaptic vesicles	1458					anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			lung(1)	1		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		TGTGCGTGAGCAGGCGCAAGC	0.657		NA											6	2					0	0	0	0
RSPO4	343637	broad.mit.edu	37	20	947818	947818	+	Silent	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr20:947818C>T	uc002wej.2	-	3	505	c.408G>A	c.(406-408)CAG>CAA	p.Q136Q	RSPO4_uc002wek.2_Silent_p.Q136Q	NM_001029871	NP_001025042	Q2I0M5	RSPO4_HUMAN	R-spondin family, member 4 isoform 1 precursor	136					Wnt receptor signaling pathway	extracellular region	heparin binding				0						CCCACTCACCCTGGCACTCCC	0.627		NA											6	29					0	0	0	0
PSMF1	9491	broad.mit.edu	37	20	1144966	1144966	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr20:1144966C>T	uc002wel.3	+	7	778	c.610C>T	c.(610-612)CGG>TGG	p.R204W	PSMF1_uc010zpo.1_Missense_Mutation_p.R116W|PSMF1_uc002wem.3_Missense_Mutation_p.R204W|PSMF1_uc010zpp.1_Missense_Mutation_p.R142W|PSMF1_uc002wen.3_Missense_Mutation_p.R204W|PSMF1_uc002wep.3_Missense_Mutation_p.R155W	NM_178578	NP_848693	Q92530	PSMF1_HUMAN	proteasome inhibitor subunit 1	204	Pro-rich.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome core complex	endopeptidase inhibitor activity|protein binding				0						CCTCAGGCCTCGGAGAGGTGG	0.552		NA											209	236					0	0	0	0
BMP2	650	broad.mit.edu	37	20	6759467	6759467	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr20:6759467G>A	uc002wmu.1	+	3	1707	c.922G>A	c.(922-924)GTG>ATG	p.V308M		NM_001200	NP_001191	P12643	BMP2_HUMAN	bone morphogenetic protein 2 preproprotein	308					BMP signaling pathway involved in heart induction|bone mineralization involved in bone maturation|cardiac cell differentiation|cardiac epithelial to mesenchymal transition|cartilage development|growth|negative regulation of cell cycle|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|pathway-restricted SMAD protein phosphorylation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cartilage development|positive regulation of endothelial cell proliferation|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of phosphatase activity|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	activin receptor activity, type II|BMP receptor binding|cytokine activity|growth factor activity|phosphatase activator activity|protein heterodimerization activity|SMAD binding|transforming growth factor beta receptor binding			ovary(1)|breast(1)	2					Simvastatin(DB00641)	CTTCAGTGACGTGGGGTGGAA	0.507		NA											26	87					0	0	0	0
PLCB1	23236	broad.mit.edu	37	20	8609052	8609052	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr20:8609052G>T	uc002wnb.2	+	4	361	c.358G>T	c.(358-360)GTG>TTG	p.V120L	PLCB1_uc010zrb.1_Missense_Mutation_p.V19L|PLCB1_uc010gbv.1_Missense_Mutation_p.V120L|PLCB1_uc002wmz.1_Missense_Mutation_p.V120L|PLCB1_uc002wna.2_Missense_Mutation_p.V120L|PLCB1_uc002wnc.1_Missense_Mutation_p.V19L	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	120					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						TTTGAATCTCGTGGCTTTCCA	0.478		NA											30	67					8.17e-17	1.14e-16	1	0
SNRPB2	6629	broad.mit.edu	37	20	16719498	16719498	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr20:16719498G>A	uc002wph.1	+	5	596	c.380G>A	c.(379-381)GGA>GAA	p.G127E	SNRPB2_uc002wpi.1_Missense_Mutation_p.G127E	NM_003092	NP_003083	P08579	RU2B_HUMAN	small nuclear ribonucleoprotein polypeptide B''	127						catalytic step 2 spliceosome|nucleoplasm|U2 snRNP	nucleotide binding|protein binding|RNA binding			large_intestine(1)	1						TTTGCTTAGGGAACTCCAAAT	0.299		NA											7	22					0	0	0	0
PAX1	5075	broad.mit.edu	37	20	21687098	21687098	+	Silent	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr20:21687098C>T	uc002wsj.2	+	2	363	c.309C>T	c.(307-309)AAC>AAT	p.N103N	PAX1_uc010zsl.1_Silent_p.N103N|PAX1_uc010zsm.1_Silent_p.N79N	NM_006192	NP_006183	P15863	PAX1_HUMAN	paired box 1	103	Paired.				regulation of transcription, DNA-dependent|skeletal system development|transcription from RNA polymerase II promoter	nucleus	DNA binding			upper_aerodigestive_tract(1)|kidney(1)	2						GCGAGGTGAACCAGCTGGGCG	0.662		NA											23	76					0	0	0	0
MYLK2	85366	broad.mit.edu	37	20	30408307	30408307	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr20:30408307C>T	uc002wwq.2	+	3	533	c.431C>T	c.(430-432)CCT>CTT	p.P144L		NM_033118	NP_149109	Q9H1R3	MYLK2_HUMAN	skeletal myosin light chain kinase	144					cardiac muscle tissue morphogenesis|regulation of muscle filament sliding		ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			lung(2)|skin(2)|ovary(1)|central_nervous_system(1)	6			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			AGGGGCTCACCTGCCTTTCTG	0.637		NA											39	40					0	0	0	0
ZNF341	84905	broad.mit.edu	37	20	32378871	32378871	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr20:32378871C>T	uc002wzy.2	+	15	2133	c.2113C>T	c.(2113-2115)CAC>TAC	p.H705Y	ZNF341_uc002wzx.2_Missense_Mutation_p.H698Y|ZNF341_uc010geq.2_Missense_Mutation_p.H615Y|ZNF341_uc010ger.2_RNA|ZNF341_uc002wzz.2_Missense_Mutation_p.H132Y	NM_032819	NP_116208	Q9BYN7	ZN341_HUMAN	zinc finger protein 341	705	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						TCAGCGCGCCCACACGGGCAA	0.612		NA											17	44					0	0	0	0
NCOA6	23054	broad.mit.edu	37	20	33337564	33337564	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr20:33337564C>A	uc002xav.2	-	10	5005	c.2434G>T	c.(2434-2436)GTC>TTC	p.V812F	NCOA6_uc002xaw.2_Missense_Mutation_p.V812F	NM_014071	NP_054790	Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	812	TBP/GTF2A-binding region.|NCOA1-binding region.|NCOA6IP-binding region.|CREBBP-binding region.|Gln-rich.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			ovary(3)|breast(3)|central_nervous_system(1)	7						GATAAACTGACATCGTTATTT	0.542		NA											48	71					1.57e-16	2.18e-16	1	0
NCOA6	23054	broad.mit.edu	37	20	33345322	33345322	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr20:33345322C>A	uc002xav.2	-	8	3800	c.1229G>T	c.(1228-1230)GGG>GTG	p.G410V	NCOA6_uc002xaw.2_Missense_Mutation_p.G410V|NCOA6_uc010gew.1_Missense_Mutation_p.G367V	NM_014071	NP_054790	Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	410	TBP/GTF2A-binding region.|NCOA1-binding region.|Gln-rich.|CREBBP-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			ovary(3)|breast(3)|central_nervous_system(1)	7						CCTAGAGGGCCCTCCCTGCAA	0.597		NA											23	51					2.28e-05	2.58e-05	1	0
CDH22	64405	broad.mit.edu	37	20	44839176	44839176	+	Silent	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr20:44839176G>T	uc002xrm.2	-	6	1457	c.1056C>A	c.(1054-1056)CCC>CCA	p.P352P	CDH22_uc010ghk.1_Silent_p.P352P|CDH22_uc002xrn.1_Silent_p.P103P	NM_021248	NP_067071	Q9UJ99	CAD22_HUMAN	cadherin 22 precursor	352	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|skin(1)	5		Myeloproliferative disorder(115;0.0122)				CGGTGTGCACGGGCTGGGATT	0.677		NA											16	11					2.94e-08	3.61e-08	1	0
FAM65C	140876	broad.mit.edu	37	20	49221286	49221286	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr20:49221286C>G	uc002xvm.2	-	12	1288	c.970G>C	c.(970-972)GTG>CTG	p.V324L	FAM65C_uc010zyt.1_Missense_Mutation_p.V328L|FAM65C_uc010zyu.1_RNA|FAM65C_uc002xvn.1_Missense_Mutation_p.V324L	NM_080829	NP_543019	Q96MK2	FA65C_HUMAN	hypothetical protein LOC140876	324										ovary(2)	2						CTGGGTGACACCAGGAAGCTC	0.602		NA											10	13					0	0	0	0
LAMA5	3911	broad.mit.edu	37	20	60887107	60887107	+	Splice_Site	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr20:60887107C>T	uc002ycq.2	-	70	9572	c.9505_splice	c.e70-1	p.D3169_splice		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor						angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ATAGCCCATCCTGGGGACGGC	0.672		NA											21	23					0	0	0	0
TPTE	7179	broad.mit.edu	37	21	10959762	10959762	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr21:10959762G>T	uc002yip.1	-	8	580	c.212C>A	c.(211-213)GCT>GAT	p.A71D	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.A53D|TPTE_uc002yir.1_Intron|TPTE_uc010gkv.1_Intron	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	71					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		AACATTTTCAGCATCTTCAAC	0.363		NA											9	192					2.74e-10	3.5e-10	1	0
DSCAM	1826	broad.mit.edu	37	21	41539196	41539196	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr21:41539196C>A	uc002yyq.1	-	16	3419	c.2967G>T	c.(2965-2967)CAG>CAT	p.Q989H	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	989	Fibronectin type-III 2.|Extracellular (Potential).				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GGTGAACTTCCTGAGGTGGAC	0.532		NA											18	42					7.45e-12	9.78e-12	1	0
COL6A2	1292	broad.mit.edu	37	21	47545908	47545908	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr21:47545908G>T	uc002zia.1	+	26	2261	c.2179G>T	c.(2179-2181)GCG>TCG	p.A727S	COL6A2_uc002zhy.1_Missense_Mutation_p.A727S|COL6A2_uc002zhz.1_Missense_Mutation_p.A727S|COL6A2_uc002zib.1_Missense_Mutation_p.A133S|COL6A2_uc002zic.1_5'Flank	NM_001849	NP_001840	P12110	CO6A2_HUMAN	alpha 2 type VI collagen isoform 2C2 precursor	727	VWFA 2.|Nonhelical region.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(7)|ovary(1)	8	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		ACGTGTGTTTGCGGTGGTCAT	0.657		NA											12	31					3.04e-14	4.12e-14	1	0
ZNF74	7625	broad.mit.edu	37	22	20760750	20760750	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr22:20760750A>C	uc010gsm.2	+	6	1639	c.1427A>C	c.(1426-1428)GAG>GCG	p.E476A	ZNF74_uc002zsg.2_Missense_Mutation_p.E405A|ZNF74_uc002zsh.2_Missense_Mutation_p.E476A|ZNF74_uc002zsi.2_Missense_Mutation_p.E405A|ZNF74_uc010gsn.2_Missense_Mutation_p.E405A	NM_003426	NP_003417	Q16587	ZNF74_HUMAN	zinc finger protein 74	476	C2H2-type 9.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	actin cytoskeleton|nucleus	DNA binding|RNA binding|zinc ion binding			ovary(1)	1	Melanoma(16;0.000465)|Ovarian(15;0.0025)|Colorectal(54;0.0221)|all_neural(72;0.219)	Lung SC(17;0.0262)|all_lung(157;0.248)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			AAGTGCAACGAGTGCGGCAAA	0.642		NA											25	53					0	0	0	0
BPIL2	254240	broad.mit.edu	37	22	32828502	32828502	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr22:32828502G>T	uc003amn.2	-	10	1007	c.1007C>A	c.(1006-1008)CCC>CAC	p.P336H	BPIL2_uc010gwo.2_Intron|BPIL2_uc011amb.1_Missense_Mutation_p.P60H	NM_174932	NP_777592	Q8NFQ6	BPIL2_HUMAN	bactericidal/permeability-increasing	336						extracellular region	lipopolysaccharide binding|phospholipid binding			ovary(1)|skin(1)	2						CACCATGAAGGGCTGGGACAA	0.488		NA											33	66					4.42e-11	5.73e-11	1	0
TRIOBP	11078	broad.mit.edu	37	22	38121264	38121264	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr22:38121264A>T	uc003atr.2	+	7	2972	c.2701A>T	c.(2701-2703)AAC>TAC	p.N901Y	TRIOBP_uc003atu.2_Missense_Mutation_p.N729Y|TRIOBP_uc003atq.1_Missense_Mutation_p.N901Y|TRIOBP_uc003ats.1_Missense_Mutation_p.N729Y	NM_001039141	NP_001034230	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein isoform 6	901					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					CCATCGTACTAACAAAGACAT	0.547		NA											99	156					0	0	0	0
GCAT	23464	broad.mit.edu	37	22	38212669	38212669	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr22:38212669G>T	uc003atz.2	+	9	1224	c.1204G>T	c.(1204-1206)GAC>TAC	p.D402Y	GCAT_uc003aua.1_Missense_Mutation_p.D428Y	NM_014291	NP_055106	O75600	KBL_HUMAN	glycine C-acetyltransferase precursor	402					biosynthetic process|cellular amino acid metabolic process		glycine C-acetyltransferase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups				0	Melanoma(58;0.045)				Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	GGAAGACATTGACCGCTGCGT	0.627		NA											43	60					7.53e-24	1.12e-23	1	0
NPTXR	23467	broad.mit.edu	37	22	39219124	39219124	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr22:39219124G>C	uc003awk.2	-	4	1396	c.1242C>G	c.(1240-1242)ATC>ATG	p.I414M		NM_014293	NP_055108	O95502	NPTXR_HUMAN	neuronal pentraxin receptor	414	Pentaxin.|Extracellular (Potential).					integral to membrane	metal ion binding			central_nervous_system(2)|skin(1)	3	Melanoma(58;0.04)					CATGAGGCTTGATGGGGTGCC	0.502		NA											28	67					0	0	0	0
ENTHD1	150350	broad.mit.edu	37	22	40140270	40140270	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr22:40140270C>T	uc003ayg.2	-	7	1489	c.1238G>A	c.(1237-1239)GGA>GAA	p.G413E		NM_152512	NP_689725	Q8IYW4	ENTD1_HUMAN	ENTH domain containing 1	413										ovary(2)|skin(1)	3	Melanoma(58;0.0749)					GGAAGATGCTCCCTCAGAAGC	0.363		NA											8	41					0	0	0	0
PKDREJ	10343	broad.mit.edu	37	22	46657867	46657867	+	Silent	SNP	G	G	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr22:46657867G>C	uc003bhh.2	-	1	1353	c.1353C>G	c.(1351-1353)CTC>CTG	p.L451L		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	451	Extracellular (Potential).|REJ.				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		TTGGTCCTTGGAGCACGTGGA	0.408		NA											43	40					0	0	0	0
PKDREJ	10343	broad.mit.edu	37	22	46658330	46658330	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr22:46658330G>A	uc003bhh.2	-	1	890	c.890C>T	c.(889-891)TCG>TTG	p.S297L		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	297	Extracellular (Potential).|REJ.				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		CCACTGTAACGAATTATTGGG	0.572		NA											125	132					0	0	0	0
TUBGCP6	85378	broad.mit.edu	37	22	50665439	50665439	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr22:50665439C>A	uc003bkb.1	-	6	1992	c.1480G>T	c.(1480-1482)GCG>TCG	p.A494S	TUBGCP6_uc010har.1_Missense_Mutation_p.A494S|TUBGCP6_uc010has.1_RNA|TUBGCP6_uc010hat.1_5'Flank|TUBGCP6_uc003bkd.1_5'Flank	NM_020461	NP_065194	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	494					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			ovary(2)|central_nervous_system(2)	4		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		GTGGGAAACGCGGCCCTGGGG	0.687		NA											4	10					0.000602214	0.000655325	1	0
MAPK8IP2	23542	broad.mit.edu	37	22	51041671	51041671	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr22:51041671G>T	uc003bmx.2	+	3	308	c.191G>T	c.(190-192)CGC>CTC	p.R64L	MAPK8IP2_uc003bmy.2_Missense_Mutation_p.R37L|MAPK8IP2_uc011asc.1_5'Flank	NM_012324	NP_036456	Q13387	JIP2_HUMAN	mitogen-activated protein kinase 8 interacting	64					behavioral fear response|dendrite morphogenesis|MAPKKK cascade|nonassociative learning|positive regulation of anti-apoptosis|regulation of excitatory postsynaptic membrane potential|regulation of JNK cascade|regulation of receptor activity|regulation of synaptic transmission, glutamatergic|signal complex assembly|social behavior	cytoplasm|postsynaptic density	beta-amyloid binding|kinesin binding|MAP-kinase scaffold activity|protein kinase activator activity|protein kinase binding			large_intestine(2)|central_nervous_system(1)	3		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		OV - Ovarian serous cystadenocarcinoma(4;1.28e-70)|Epithelial(4;3.46e-65)|GBM - Glioblastoma multiforme(4;4.83e-06)|Lung(4;0.125)|BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		TCCCTGGGGCGCTCGGAGCAG	0.527		NA											16	14					2.32e-09	2.92e-09	1	0
CNTN4	152330	broad.mit.edu	37	3	3081938	3081938	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:3081938T>G	uc003bpc.2	+	19	2602	c.2381T>G	c.(2380-2382)GTG>GGG	p.V794G	CNTN4_uc003bpb.1_Missense_Mutation_p.V465G|CNTN4_uc003bpe.2_Missense_Mutation_p.V466G|CNTN4_uc003bpf.2_Missense_Mutation_p.V465G|CNTN4_uc003bpg.2_Missense_Mutation_p.V50G	NM_175607	NP_783200	Q8IWV2	CNTN4_HUMAN	contactin 4 isoform a precursor	794	Fibronectin type-III 2.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			large_intestine(2)|ovary(2)|lung(1)|central_nervous_system(1)|pancreas(1)	7		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		ACCACGGTGGTGTATTCTGCA	0.428		NA											25	17					0	0	0	0
CHCHD4	131474	broad.mit.edu	37	3	14154541	14154541	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:14154541C>T	uc003byj.3	-	3	470	c.275G>A	c.(274-276)CGG>CAG	p.R92Q	CHCHD4_uc003byi.3_Missense_Mutation_p.R105Q	NM_001098502	NP_001091972	Q8N4Q1	MIA40_HUMAN	coiled-coil-helix-coiled-coil-helix domain	92	CHCH.				protein transport|transmembrane transport	mitochondrial intermembrane space					0						CTGCATGGCCCGGAACTGGTC	0.388		NA											3	45					0	0	0	0
XPC	7508	broad.mit.edu	37	3	14220052	14220052	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:14220052G>C	uc011ave.1	-	1	121	c.17C>G	c.(16-18)GCG>GGG	p.A6G	XPC_uc011avf.1_5'UTR|XPC_uc011avg.1_Missense_Mutation_p.A6G|LSM3_uc003byn.2_5'Flank	NM_004628	NP_004619	Q01831	XPC_HUMAN	xeroderma pigmentosum, complementation group C	6					nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA damage removal	cytoplasm|nucleoplasm|XPC complex	bubble DNA binding|damaged DNA binding|loop DNA binding|protein binding|single-stranded DNA binding			ovary(2)|breast(1)	3						CCCGCCGGCCGCGCGTTTCCG	0.701		NA	Mis|N|F|S			skin basal cell|skin squamous cell|melanoma		NER	Xeroderma_Pigmentosum				5	37					0	0	0	0
C3orf20	84077	broad.mit.edu	37	3	14745912	14745912	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:14745912C>T	uc003byy.2	+	7	1351	c.947C>T	c.(946-948)GCA>GTA	p.A316V	C3orf20_uc003byz.2_Missense_Mutation_p.A194V|C3orf20_uc003bza.2_Missense_Mutation_p.A194V|C3orf20_uc003byx.1_Intron	NM_032137	NP_115513	Q8ND61	CC020_HUMAN	hypothetical protein LOC84077	316						cytoplasm|integral to membrane				ovary(3)|skin(1)	4						AACTACAAGGCAAAGATGCCC	0.512		NA											46	26					0	0	0	0
GALNTL2	117248	broad.mit.edu	37	3	16254215	16254215	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:16254215G>T	uc003car.3	+	6	1812	c.1337G>T	c.(1336-1338)GGG>GTG	p.G446V	GALNTL2_uc003caq.3_Missense_Mutation_p.G179V	NM_054110	NP_473451	Q8N3T1	GLTL2_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	446	Lumenal (Potential).					Golgi membrane|integral to membrane|transport vesicle	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(1)	1						ACCTGGCTGGGGTCATTCAAA	0.557		NA											41	25					5.45e-19	7.77e-19	1	0
ARPP21	10777	broad.mit.edu	37	3	35778754	35778754	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:35778754G>A	uc003cgb.2	+	16	1808	c.1544G>A	c.(1543-1545)GGG>GAG	p.G515E	ARPP21_uc003cga.2_Missense_Mutation_p.G461E|ARPP21_uc011axy.1_Missense_Mutation_p.G481E|ARPP21_uc003cgf.2_Missense_Mutation_p.G316E|ARPP21_uc003cgg.2_Missense_Mutation_p.G3E	NM_016300	NP_057384	Q9UBL0	ARP21_HUMAN	cyclic AMP-regulated phosphoprotein, 21 kD	515	Gln-rich.					cytoplasm	nucleic acid binding			ovary(2)|skin(1)	3						GCCATGGTGGGGCAGTCCCAA	0.627		NA											30	27					0	0	0	0
SCN11A	11280	broad.mit.edu	37	3	38889201	38889201	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:38889201G>T	uc011ays.1	-	26	4559	c.4360C>A	c.(4360-4362)CAC>AAC	p.H1454N		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	1454	IV.				response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	AAAGGAATGTGCTCCTGATTT	0.502		NA											19	10					4.31e-22	6.32e-22	1	0
SCN11A	11280	broad.mit.edu	37	3	38951680	38951680	+	Nonsense_Mutation	SNP	A	A	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:38951680A>T	uc011ays.1	-	8	1177	c.978T>A	c.(976-978)TAT>TAA	p.Y326*		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	326	I.				response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	GCTTACATTCATATTGTATGG	0.383		NA											44	17					0	0	0	0
CDCP1	64866	broad.mit.edu	37	3	45152275	45152275	+	Silent	SNP	G	G	T	rs151241354		TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:45152275G>T	uc003com.2	-	4	849	c.714C>A	c.(712-714)GCC>GCA	p.A238A	CDCP1_uc003con.2_Silent_p.A238A	NM_022842	NP_073753	Q9H5V8	CDCP1_HUMAN	CUB domain-containing protein 1 isoform 1	238	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.00928)|KIRC - Kidney renal clear cell carcinoma(197;0.0519)|Kidney(197;0.0651)		CTGGGTAGTTGGCAGACATCA	0.542		NA											10	139					1.59e-06	1.87e-06	1	0
DHX30	22907	broad.mit.edu	37	3	47890739	47890739	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:47890739C>T	uc003cru.2	+	19	3413	c.2987C>T	c.(2986-2988)TCG>TTG	p.S996L	DHX30_uc003crt.2_Missense_Mutation_p.S957L|MIR1226_hsa-mir-1226|MI0006313_5'Flank	NM_138615	NP_619520	Q7L2E3	DHX30_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 30	996						mitochondrial nucleoid	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			ovary(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;0.000696)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		GGGAAGCCCTCGGACTGCACC	0.597		NA											5	54					0	0	0	0
BSN	8927	broad.mit.edu	37	3	49690362	49690362	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:49690362G>C	uc003cxe.3	+	5	3487	c.3373G>C	c.(3373-3375)GAG>CAG	p.E1125Q		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	1125					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		CTCCTGCTCTGAGTACTCACC	0.612		NA											36	27					0	0	0	0
PARP3	10039	broad.mit.edu	37	3	51982442	51982442	+	Silent	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:51982442C>T	uc003dby.2	+	11	1919	c.1548C>T	c.(1546-1548)CTC>CTT	p.L516L	PARP3_uc003dbz.2_Silent_p.L523L	NM_005485	NP_005476	Q9Y6F1	PARP3_HUMAN	poly (ADP-ribose) polymerase family, member 3	516	PARP catalytic.				DNA repair|protein ADP-ribosylation	centriole|nucleus	NAD+ ADP-ribosyltransferase activity|protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000541)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		GCGAGTACCTCATCTACCAGG	0.642		NA											38	15					0	0	0	0
SFMBT1	51460	broad.mit.edu	37	3	52945182	52945182	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:52945182C>A	uc003dgf.2	-	18	2312	c.1743G>T	c.(1741-1743)AAG>AAT	p.K581N	SFMBT1_uc010hmr.2_Missense_Mutation_p.K528N|SFMBT1_uc003dgg.2_Missense_Mutation_p.K581N|SFMBT1_uc003dgh.2_Missense_Mutation_p.K581N	NM_001005159	NP_001005159	Q9UHJ3	SMBT1_HUMAN	Scm-like with four mbt domains 1	581					regulation of transcription, DNA-dependent	nucleus				ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;9.91e-05)|Kidney(197;0.000644)|KIRC - Kidney renal clear cell carcinoma(197;0.000792)|OV - Ovarian serous cystadenocarcinoma(275;0.113)		CCCGATAACTCTTTCCTTTAT	0.388		NA											41	22					1.62e-14	2.21e-14	1	0
COL8A1	1295	broad.mit.edu	37	3	99513341	99513341	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:99513341C>A	uc003dtg.1	+	5	841	c.596C>A	c.(595-597)CCA>CAA	p.P199Q	COL8A1_uc003dth.1_Missense_Mutation_p.P199Q|COL8A1_uc003dti.1_Missense_Mutation_p.P200Q	NM_001850	NP_001841	P27658	CO8A1_HUMAN	alpha 1 type VIII collagen precursor	199	Triple-helical region (COL1).				angiogenesis|cell adhesion	basement membrane|collagen type VIII					0						CAAGGACCTCCAGGGCCTCAT	0.592		NA											23	27					2.28e-05	2.58e-05	1	0
ABI3BP	25890	broad.mit.edu	37	3	100621495	100621495	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:100621495C>A	uc003dun.2	-	3	401	c.316G>T	c.(316-318)GCT>TCT	p.A106S	ABI3BP_uc003duo.2_Missense_Mutation_p.A99S|ABI3BP_uc003dup.3_Missense_Mutation_p.A99S	NM_015429	NP_056244	Q7Z7G0	TARSH_HUMAN	ABI gene family, member 3 (NESH) binding protein	106						extracellular space				ovary(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)	4						GGAGGTGGAGCAGGTCGCACA	0.398		NA											17	27					2.71e-06	3.16e-06	1	0
WDR52	55779	broad.mit.edu	37	3	113099870	113099870	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:113099870T>C	uc003eae.1	-	16	1974	c.1928A>G	c.(1927-1929)TAT>TGT	p.Y643C		NM_018338	NP_060808	Q96MT7	WDR52_HUMAN	WD repeat domain 52 isoform 2	643										central_nervous_system(1)	1						TTCAAGAATATAGCCATTTTC	0.299		NA											30	47					0	0	0	0
HCLS1	3059	broad.mit.edu	37	3	121352001	121352001	+	Silent	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:121352001C>A	uc003eeh.3	-	11	1046	c.921G>T	c.(919-921)GGG>GGT	p.G307G	HCLS1_uc011bjj.1_Silent_p.G270G|HCLS1_uc011bjk.1_RNA	NM_005335	NP_005326	P14317	HCLS1_HUMAN	hematopoietic cell-specific Lyn substrate 1	307					erythrocyte differentiation|intracellular signal transduction|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of STAT protein|response to hormone stimulus	mitochondrion|nucleus|plasma membrane	DNA binding|sequence-specific DNA binding transcription factor activity				0				GBM - Glioblastoma multiforme(114;0.0912)		ATGGAGGAGTCCCAACTGGAG	0.468		NA											8	5					0.00307968	0.00328896	1	0
PARP9	83666	broad.mit.edu	37	3	122277281	122277281	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:122277281C>A	uc010hri.2	-	3	194	c.49G>T	c.(49-51)GGT>TGT	p.G17C	PARP9_uc003eff.3_Nonsense_Mutation_p.E17*|PARP9_uc011bjs.1_Nonsense_Mutation_p.E17*|PARP9_uc003efg.2_Missense_Mutation_p.D17Y|PARP9_uc003efi.2_Nonsense_Mutation_p.E17*|PARP9_uc003efh.2_Missense_Mutation_p.G17C|PARP9_uc003efj.2_Nonsense_Mutation_p.E17*	NM_001146102	NP_001139574	Q8IXQ6	PARP9_HUMAN	poly (ADP-ribose) polymerase family, member 9	17					cell migration	cytosol|nucleus	NAD+ ADP-ribosyltransferase activity|protein binding			ovary(1)|pancreas(1)|prostate(1)|skin(1)	4				GBM - Glioblastoma multiforme(114;0.0519)		GTAATCCTACCTGATTTTTCA	0.423		NA											40	42					1.07e-22	1.58e-22	1	0
KIAA1257	57501	broad.mit.edu	37	3	128695838	128695838	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:128695838C>T	uc003elj.3	-	6	1076	c.880G>A	c.(880-882)GAT>AAT	p.D294N	KIAA1257_uc003elg.1_Missense_Mutation_p.D294N|KIAA1257_uc003eli.3_Missense_Mutation_p.D182N	NM_020741	NP_065792	Q9ULG3	K1257_HUMAN	hypothetical protein LOC57501	294											0						GTGGAAGAATCGTCCATTTTG	0.443		NA											18	21					0	0	0	0
DZIP1L	199221	broad.mit.edu	37	3	137822454	137822454	+	Silent	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:137822454G>A	uc003erq.2	-	2	723	c.360C>T	c.(358-360)GGC>GGT	p.G120G	DZIP1L_uc003err.1_Silent_p.G120G	NM_173543	NP_775814	Q8IYY4	DZI1L_HUMAN	DAZ interacting protein 1-like	120						intracellular	zinc ion binding			ovary(1)|pancreas(1)	2						GCTGCTGCTGGCCCAGGCTGG	0.662		NA											10	14					0	0	0	0
A4GNT	51146	broad.mit.edu	37	3	137850025	137850025	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:137850025A>T	uc003ers.2	-	2	276	c.74T>A	c.(73-75)CTG>CAG	p.L25Q		NM_016161	NP_057245	Q9UNA3	A4GCT_HUMAN	alpha-1,4-N-acetylglucosaminyltransferase	25	Helical; Signal-anchor for type II membrane protein; (Potential).				protein O-linked glycosylation	Golgi membrane|Golgi stack|integral to membrane|membrane fraction	acetylglucosaminyltransferase activity|galactosyltransferase activity			central_nervous_system(1)	1						GCTGGACTTCAGGGTGAACTG	0.567		NA											14	21					0	0	0	0
PLSCR4	57088	broad.mit.edu	37	3	145917674	145917674	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:145917674G>A	uc010huy.2	-	6	879	c.550C>T	c.(550-552)CGA>TGA	p.R184*	PLSCR4_uc010huz.2_Nonsense_Mutation_p.R184*|PLSCR4_uc003evt.3_Nonsense_Mutation_p.R184*|PLSCR4_uc010hva.2_Intron|PLSCR4_uc003evu.3_Intron	NM_001128305	NP_001121777	Q9NRQ2	PLS4_HUMAN	phospholipid scramblase 4 isoform a	184	Cytoplasmic (By similarity).				blood coagulation|phospholipid scrambling	integral to membrane	calcium ion binding|phospholipid scramblase activity|SH3 domain binding				0						ATGATTTCTCGGCCCATACAA	0.502		NA											15	15					0	0	0	0
MED12L	116931	broad.mit.edu	37	3	151082807	151082807	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:151082807G>C	uc003eyp.2	+	20	2931	c.2893G>C	c.(2893-2895)GTG>CTG	p.V965L	MED12L_uc011bnz.1_Missense_Mutation_p.V825L|P2RY12_uc011boa.1_Intron|P2RY12_uc003eyx.1_Intron|MED12L_uc003eyy.1_Missense_Mutation_p.V128L	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	965					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			ATATAATAACGTGATGCCTGC	0.363		NA											68	97					0	0	0	0
PLCH1	23007	broad.mit.edu	37	3	155218533	155218533	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:155218533G>T	uc011bok.1	-	13	1996	c.1719C>A	c.(1717-1719)GAC>GAA	p.D573E	PLCH1_uc011boj.1_Missense_Mutation_p.D573E|PLCH1_uc011bol.1_Missense_Mutation_p.D555E	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	573					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			TCTGCTGTGTGTCTTCCTCAT	0.428		NA											14	129					1.57e-10	2.02e-10	1	0
GMPS	8833	broad.mit.edu	37	3	155632262	155632262	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:155632262A>G	uc003faq.2	+	8	1276	c.941A>G	c.(940-942)GAT>GGT	p.D314G	GMPS_uc011bom.1_Missense_Mutation_p.D215G	NM_003875	NP_003866	P49915	GUAA_HUMAN	guanine monophosphate synthetase	314					glutamine metabolic process|purine base biosynthetic process	cytosol	ATP binding|GMP synthase (glutamine-hydrolyzing) activity|GMP synthase activity			ovary(2)|lung(1)	3			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)		L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	CCAATATCAGATGAAGATAGA	0.358		NA	T	MLL	AML								8	84					0	0	0	0
VEPH1	79674	broad.mit.edu	37	3	157099093	157099093	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:157099093G>T	uc003fbj.1	-	7	1296	c.979C>A	c.(979-981)CTC>ATC	p.L327I	VEPH1_uc003fbk.1_Missense_Mutation_p.L327I|VEPH1_uc010hvu.1_Missense_Mutation_p.L327I	NM_024621	NP_078897	Q14D04	MELT_HUMAN	ventricular zone expressed PH domain homolog 1	327						plasma membrane				breast(3)|ovary(1)|lung(1)	5			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			TCCAGCAGGAGAATATGGTGA	0.498		NA											42	48					3.43e-23	5.08e-23	1	0
SI	6476	broad.mit.edu	37	3	164737463	164737463	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:164737463A>T	uc003fei.2	-	28	3412	c.3350T>A	c.(3349-3351)GTG>GAG	p.V1117E		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1117	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TGTATGTTCCACTTCCCCAAA	0.438		NA								HNSCC(35;0.089)			19	76					0	0	0	0
SI	6476	broad.mit.edu	37	3	164750444	164750444	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:164750444G>T	uc003fei.2	-	24	2664	c.2602C>A	c.(2602-2604)CAG>AAG	p.Q868K		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	868	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	GTTCCTTCCTGATATGATGAA	0.343		NA								HNSCC(35;0.089)			16	21					2.35e-11	3.07e-11	1	0
HTR3C	170572	broad.mit.edu	37	3	183776222	183776222	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:183776222C>A	uc003fmk.2	+	6	601	c.567C>A	c.(565-567)AGC>AGA	p.S189R		NM_130770	NP_570126	Q8WXA8	5HT3C_HUMAN	5-hydroxytryptamine receptor 3 subunit C	189	Extracellular (Potential).					integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(143;2.33e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			CAGTGGACAGCATGCTGCTGG	0.567		NA											6	90					0.00198382	0.00212623	1	0
HTR3C	170572	broad.mit.edu	37	3	183776244	183776244	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:183776244G>A	uc003fmk.2	+	6	623	c.589G>A	c.(589-591)GAG>AAG	p.E197K		NM_130770	NP_570126	Q8WXA8	5HT3C_HUMAN	5-hydroxytryptamine receptor 3 subunit C	197	Extracellular (Potential).					integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(143;2.33e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			CATGGACAAGGAGGTGTGGGA	0.582		NA											9	108					0	0	0	0
MASP1	5648	broad.mit.edu	37	3	186944202	186944202	+	Silent	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:186944202G>T	uc003frh.1	-	12	1880	c.1548C>A	c.(1546-1548)ATC>ATA	p.I516I		NM_001879	NP_001870	P48740	MASP1_HUMAN	mannan-binding lectin serine protease 1 isoform	516	Peptidase S1.				complement activation, lectin pathway|negative regulation of complement activation|proteolysis	extracellular space	calcium ion binding|calcium-dependent protein binding|protein binding|protein homodimerization activity|serine-type endopeptidase activity			ovary(2)|breast(1)|liver(1)	4	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.49e-18)	GBM - Glioblastoma multiforme(93;0.0366)		CACCCAGGATGATTTTGAAGT	0.567		NA											6	21					5.94e-07	7.05e-07	1	0
ATP13A5	344905	broad.mit.edu	37	3	193042775	193042775	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:193042775C>A	uc011bsq.1	-	14	1552	c.1552G>T	c.(1552-1554)GGC>TGC	p.G518C		NM_198505	NP_940907	Q4VNC0	AT135_HUMAN	ATPase type 13A5	518					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(5)|skin(4)|large_intestine(2)	11	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		ACAGCCTGGCCTGAGGCAAAG	0.502		NA											36	284					2.42e-17	3.37e-17	1	0
ATP13A3	79572	broad.mit.edu	37	3	194149602	194149602	+	Silent	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:194149602C>T	uc003fty.3	-	27	3321	c.2919G>A	c.(2917-2919)CTG>CTA	p.L973L		NM_024524	NP_078800	Q9H7F0	AT133_HUMAN	ATPase type 13A3	973	Helical; (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(1)	1	all_cancers(143;6.01e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;3.83e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;5.98e-05)		AAATGATTGCCAGATCAATGA	0.274		NA											12	94					0	0	0	0
TMEM44	93109	broad.mit.edu	37	3	194344010	194344010	+	Silent	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:194344010C>A	uc010hzn.2	-	5	724	c.555G>T	c.(553-555)CTG>CTT	p.L185L	TMEM44_uc003fue.2_Silent_p.L185L|TMEM44_uc003fud.2_Silent_p.L185L|TMEM44_uc003fuf.2_Silent_p.L185L|TMEM44_uc011bsv.1_Silent_p.L185L|TMEM44_uc003fuh.1_RNA	NM_001011655	NP_001011655	Q2T9K0	TMM44_HUMAN	transmembrane protein 44 isoform b	185	Helical; (Potential).					integral to membrane					0	all_cancers(143;1.41e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;4.34e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;9.06e-06)		CAACGCTACCCAGCAGGTAGC	0.572		NA											28	17					4.15e-07	4.95e-07	1	0
MUC4	4585	broad.mit.edu	37	3	195479980	195479980	+	Silent	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:195479980G>A	uc011bto.1	-	21	15526	c.15066C>T	c.(15064-15066)GCC>GCT	p.A5022A	MUC4_uc010hzq.2_Silent_p.A7A|MUC4_uc003fuz.2_Silent_p.A748A|MUC4_uc003fva.2_Silent_p.A630A|MUC4_uc003fvb.2_Silent_p.A666A|MUC4_uc003fvc.2_RNA|MUC4_uc003fvd.2_RNA|MUC4_uc003fve.2_Silent_p.A666A|MUC4_uc010hzr.2_RNA|MUC4_uc011btf.1_Silent_p.A630A|MUC4_uc011btg.1_RNA|MUC4_uc011bth.1_Silent_p.A714A|MUC4_uc011bti.1_Silent_p.A714A|MUC4_uc011btj.1_Silent_p.A891A|MUC4_uc011btk.1_Silent_p.A630A|MUC4_uc011btl.1_Silent_p.A659A|MUC4_uc011btm.1_Silent_p.A839A|MUC4_uc011btn.1_Silent_p.A630A|MUC4_uc003fvo.2_Silent_p.A914A|MUC4_uc003fvp.2_Silent_p.A863A	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	1907	EGF-like 1.				cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		TGTCAGTGAAGGCTGGGGGGC	0.592		NA											77	191					0	0	0	0
LMLN	89782	broad.mit.edu	37	3	197707351	197707351	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:197707351G>A	uc011buo.1	+	6	726	c.704G>A	c.(703-705)TGT>TAT	p.C235Y	LMLN_uc003fyt.2_Missense_Mutation_p.C183Y|LMLN_uc010iar.2_Missense_Mutation_p.C235Y|LMLN_uc010ias.2_Missense_Mutation_p.C183Y|LMLN_uc003fyu.2_5'UTR	NM_033029	NP_149018	Q96KR4	LMLN_HUMAN	leishmanolysin-like isoform 2	235					cell adhesion|cell division|mitosis|proteolysis	cytoplasm|membrane	metalloendopeptidase activity|zinc ion binding			skin(1)	1	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)	Lung NSC(153;0.132)	Epithelial(36;9.84e-24)|all cancers(36;3.18e-22)|OV - Ovarian serous cystadenocarcinoma(49;5.35e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.111)		GCAGCCTATTGTCAGCAGGAA	0.433		NA											13	277					0	0	0	0
CWH43	80157	broad.mit.edu	37	4	49000563	49000563	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr4:49000563C>T	uc003gyv.2	+	6	982	c.800C>T	c.(799-801)ACA>ATA	p.T267I	CWH43_uc011bzl.1_Missense_Mutation_p.T240I	NM_025087	NP_079363	Q9H720	PG2IP_HUMAN	cell wall biogenesis 43 C-terminal homolog	267					GPI anchor biosynthetic process	integral to membrane				skin(2)|ovary(1)	3						TGGTGGGTTACAGGTATGTGG	0.453		NA											48	20					0	0	0	0
EXOC1	55763	broad.mit.edu	37	4	56744196	56744196	+	Silent	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr4:56744196G>A	uc003hbe.1	+	9	1346	c.1188G>A	c.(1186-1188)AAG>AAA	p.K396K	EXOC1_uc003hbf.1_Silent_p.K396K|EXOC1_uc003hbg.1_Silent_p.K396K	NM_018261	NP_060731	Q9NV70	EXOC1_HUMAN	exocyst complex component 1 isoform 1	396					exocytosis|protein transport	exocyst	protein binding			ovary(2)|skin(2)|lung(1)|central_nervous_system(1)	6	Glioma(25;0.08)|all_neural(26;0.101)					AGTGGCTAAAGAGTACAGATT	0.383		NA											46	31					0	0	0	0
NUP54	53371	broad.mit.edu	37	4	77039260	77039260	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr4:77039260G>A	uc003hjs.2	-	10	1380	c.1252C>T	c.(1252-1254)CAG>TAG	p.Q418*	NUP54_uc010ije.2_Nonsense_Mutation_p.Q136*|NUP54_uc011cbs.1_Nonsense_Mutation_p.Q238*|NUP54_uc011cbt.1_Nonsense_Mutation_p.Q370*|NUP54_uc003hjt.2_Nonsense_Mutation_p.Q202*	NM_017426	NP_059122	Q7Z3B4	NUP54_HUMAN	nucleoporin 54kDa	418	9 X 2 AA repeats of F-G.				carbohydrate metabolic process|glucose transport|mRNA transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleoplasm				ovary(1)|lung(1)	2						AGTTCACCCTGAATCGTATCC	0.383		NA											10	55					0	0	0	0
GRID2	2895	broad.mit.edu	37	4	94377028	94377028	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr4:94377028G>C	uc011cdt.1	+	11	2019	c.1761G>C	c.(1759-1761)TTG>TTC	p.L587F	GRID2_uc011cdu.1_Missense_Mutation_p.L492F	NM_001510	NP_001501	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	587	Helical; (Potential).				glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	TCTACCTCTTGAACTGGCTTA	0.453		NA											8	74					0	0	0	0
PDHA2	5161	broad.mit.edu	37	4	96762223	96762223	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr4:96762223G>A	uc003htr.3	+	1	985	c.922G>A	c.(922-924)GTA>ATA	p.V308I		NM_005390	NP_005381	P29803	ODPAT_HUMAN	pyruvate dehydrogenase E1 alpha 2 precursor	308					glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	AATTCAGGAAGTAAGAAGTAA	0.438		NA											38	22					0	0	0	0
DDIT4L	115265	broad.mit.edu	37	4	101111077	101111077	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr4:101111077C>A	uc003hvq.2	-	2	267	c.64G>T	c.(64-66)GGC>TGC	p.G22C		NM_145244	NP_660287	Q96D03	DDT4L_HUMAN	DNA-damage-inducible transcript 4-like	22					negative regulation of signal transduction	cytoplasm				ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;5.75e-09)		GGGTGATAGCCACAGTCCAGC	0.592		NA											27	16					1.08e-15	1.49e-15	1	0
NHEDC1	150159	broad.mit.edu	37	4	103870556	103870556	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr4:103870556C>A	uc003hww.2	-	4	362	c.240G>T	c.(238-240)ATG>ATT	p.M80I	NHEDC1_uc003hwu.2_Missense_Mutation_p.M80I|NHEDC1_uc010ilm.2_5'UTR|NHEDC1_uc003hwv.2_Intron|NHEDC1_uc011cev.1_Intron	NM_139173	NP_631912	Q4ZJI4	NHDC1_HUMAN	Na+/H+ exchanger domain containing 1 isoform 1	80	Helical; (Potential).					integral to membrane	solute:hydrogen antiporter activity			ovary(1)|skin(1)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;1.5e-08)		TTGACCAGGTCATACACCATA	0.338		NA											37	35					9.15e-12	1.2e-11	1	0
ANK2	287	broad.mit.edu	37	4	114238907	114238907	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr4:114238907C>T	uc003ibe.3	+	25	2838	c.2738C>T	c.(2737-2739)GCC>GTC	p.A913V	ANK2_uc003ibd.3_Missense_Mutation_p.A892V|ANK2_uc003ibf.3_Missense_Mutation_p.A913V|ANK2_uc011cgc.1_Missense_Mutation_p.A122V|ANK2_uc003ibg.3_5'Flank|ANK2_uc003ibc.2_Missense_Mutation_p.A889V|ANK2_uc011cgb.1_Missense_Mutation_p.A928V	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	913					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CTGAGCCATGCCTCCTACCTG	0.527		NA											26	18					0	0	0	0
ANK2	287	broad.mit.edu	37	4	114275560	114275560	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr4:114275560C>T	uc003ibe.3	+	38	5886	c.5786C>T	c.(5785-5787)TCG>TTG	p.S1929L	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_5'Flank|ANK2_uc011cgb.1_Missense_Mutation_p.S1944L	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	1896	Repeat-rich region.|Repeat A; approximate.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CCGCCAGTATCGCCTGGGAGA	0.522		NA											12	27					0	0	0	0
TNIP3	79931	broad.mit.edu	37	4	122075747	122075748	+	Nonsense_Mutation	DNP	CC	CC	AA			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr4:122075747_122075748CC>AA	uc010ing.2	-	5	646_647	c.450_451GG>TT	c.(448-453)AAGGAA>AATTAA	p.150_151KE>N*	TNIP3_uc010inh.2_Nonsense_Mutation_p.150_151KE>N*|TNIP3_uc011cgj.1_Nonsense_Mutation_p.208_209KE>N*|TNIP3_uc010ini.2_Nonsense_Mutation_p.150_151KE>N*	NM_024873	NP_079149	Q96KP6	TNIP3_HUMAN	TNFAIP3 interacting protein 3	150_151	Potential.									ovary(1)	1						TGTTCCTTTTCCTTGTTCGCAA	0.347		NA											19	14					0	0	0	0
ANKRD50	57182	broad.mit.edu	37	4	125591844	125591844	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr4:125591844C>T	uc003ifg.3	-	3	2854	c.2588G>A	c.(2587-2589)TGT>TAT	p.C863Y	ANKRD50_uc011cgo.1_Missense_Mutation_p.C684Y|ANKRD50_uc010inw.2_Missense_Mutation_p.C863Y	NM_020337	NP_065070	Q9ULJ7	ANR50_HUMAN	ankyrin repeat domain 50	863	ANK 12.									central_nervous_system(1)	1						AAGTGCTTCACATATCAATCT	0.408		NA											63	29					0	0	0	0
FAT4	79633	broad.mit.edu	37	4	126336137	126336137	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr4:126336137G>T	uc003ifj.3	+	5	6019	c.6019G>T	c.(6019-6021)GAT>TAT	p.D2007Y	FAT4_uc011cgp.1_Missense_Mutation_p.D305Y	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	2007	Cadherin 19.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						AAAAGCTTTGGATCGGGAAAG	0.443		NA											75	48					2.15e-50	3.36e-50	1	0
INTU	27152	broad.mit.edu	37	4	128637585	128637585	+	Silent	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr4:128637585C>T	uc003ifk.1	+	16	2893	c.2823C>T	c.(2821-2823)ACC>ACT	p.T941T	INTU_uc011cgq.1_RNA	NM_015693	NP_056508	Q9ULD6	PDZD6_HUMAN	PDZ domain containing 6	941										ovary(1)	1						TTGGGTTAACCTTGTAGCTGT	0.358		NA											22	17					0	0	0	0
LRAT	9227	broad.mit.edu	37	4	155665906	155665906	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr4:155665906G>A	uc003iom.1	+	1	755	c.428G>A	c.(427-429)CGG>CAG	p.R143Q	uc003iol.2_Intron|LRAT_uc003ion.1_Missense_Mutation_p.R143Q	NM_004744	NP_004735	O95237	LRAT_HUMAN	lecithin retinol acyltransferase	143	Cytoplasmic (By similarity).				response to stimulus|retinoid metabolic process|steroid metabolic process|visual perception	endoplasmic reticulum membrane|integral to membrane|multivesicular body|perinuclear region of cytoplasm|rough endoplasmic reticulum	phosphatidylcholine-retinol O-acyltransferase activity			central_nervous_system(1)	1	all_hematologic(180;0.215)	Renal(120;0.0458)			Vitamin A(DB00162)	GAGGTGGCGCGGAGGGCTGAA	0.582		NA											33	19					0	0	0	0
TDO2	6999	broad.mit.edu	37	4	156831334	156831334	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr4:156831334C>A	uc003ipf.1	+	6	653	c.589C>A	c.(589-591)CAG>AAG	p.Q197K		NM_005651	NP_005642	P48775	T23O_HUMAN	tryptophan 2,3-dioxygenase	197					tryptophan catabolic process to kynurenine	cytosol	tryptophan 2,3-dioxygenase activity				0	all_hematologic(180;0.24)	Renal(120;0.0854)		KIRC - Kidney renal clear cell carcinoma(143;0.0455)|Kidney(143;0.0568)|COAD - Colon adenocarcinoma(41;0.141)	L-Tryptophan(DB00150)	TAAATCTGAGCAGGAAAAGAC	0.328		NA											34	26					3.3e-07	3.94e-07	1	0
FRG1	2483	broad.mit.edu	37	4	190878615	190878615	+	Silent	SNP	A	A	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr4:190878615A>T	uc003izs.2	+	6	686	c.495A>T	c.(493-495)ATA>ATT	p.I165I		NM_004477	NP_004468	Q14331	FRG1_HUMAN	FSHD region gene 1	165					rRNA processing	Cajal body|catalytic step 2 spliceosome|nuclear speck|nucleolus					0		all_cancers(14;1.44e-58)|all_epithelial(14;6.32e-41)|all_lung(41;8.13e-17)|Lung NSC(41;2.13e-16)|Breast(6;2.54e-06)|Melanoma(20;0.000263)|Hepatocellular(41;0.00213)|Renal(120;0.0183)|all_hematologic(60;0.0358)|Prostate(90;0.0421)|all_neural(102;0.147)		all cancers(3;1.73e-30)|Epithelial(3;5.85e-30)|OV - Ovarian serous cystadenocarcinoma(60;5.56e-15)|BRCA - Breast invasive adenocarcinoma(30;9.14e-06)|Lung(3;3.54e-05)|STAD - Stomach adenocarcinoma(60;8.83e-05)|LUSC - Lung squamous cell carcinoma(40;0.000198)|GBM - Glioblastoma multiforme(59;0.00892)|READ - Rectum adenocarcinoma(43;0.161)		CAGGGGACATAGAAGCAAAAA	0.378		NA											22	113					0	0	0	0
TPPP	11076	broad.mit.edu	37	5	677917	677917	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:677917C>A	uc003jbg.3	-	1	977	c.259G>T	c.(259-261)GAC>TAC	p.D87Y	TPPP_uc003jbh.3_Missense_Mutation_p.D87Y	NM_007030	NP_008961	O94811	TPPP_HUMAN	tubulin polymerization promoting protein	87	Mediates interaction with LIMK1.				microtubule bundle formation|microtubule polymerization|positive regulation of protein polymerization	nucleus|perinuclear region of cytoplasm|soluble fraction	calcium ion binding|microtubule binding				0		Ovarian(839;0.0563)	Epithelial(17;0.000445)|all cancers(22;0.00176)|OV - Ovarian serous cystadenocarcinoma(19;0.00227)|Lung(60;0.0863)	GBM - Glioblastoma multiforme(108;0.0191)		TTCCTGCCGTCGATCACCTGG	0.642		NA											33	56					8.42e-14	1.13e-13	1	0
NSUN2	54888	broad.mit.edu	37	5	6609987	6609987	+	Silent	SNP	T	T	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:6609987T>A	uc003jdu.2	-	12	1340	c.1275A>T	c.(1273-1275)GCA>GCT	p.A425A	NSUN2_uc003jdt.2_Silent_p.A189A|NSUN2_uc011cmk.1_Silent_p.A390A|NSUN2_uc003jdv.2_Silent_p.A189A	NM_017755	NP_060225	Q08J23	NSUN2_HUMAN	NOL1/NOP2/Sun domain family, member 2	425						cytoplasm|nucleolus	tRNA (cytosine-5-)-methyltransferase activity|tRNA binding			ovary(1)	1						TCACCAATACTGCCACAAAAA	0.328		NA											35	40					0	0	0	0
FASTKD3	79072	broad.mit.edu	37	5	7867502	7867502	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:7867502C>T	uc003jeb.2	-	2	832	c.695G>A	c.(694-696)GGT>GAT	p.G232D	FASTKD3_uc011cmp.1_5'UTR|FASTKD3_uc003jec.2_Intron|MTRR_uc010itn.1_5'Flank|MTRR_uc003jee.3_5'Flank|MTRR_uc003jed.2_5'Flank|MTRR_uc003jef.3_5'Flank|MTRR_uc003jeg.3_5'Flank|MTRR_uc010ito.2_5'Flank	NM_024091	NP_076996	Q14CZ7	FAKD3_HUMAN	FAST kinase domains 3	232					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			ovary(2)|breast(1)|pancreas(1)	4						TGTCACACAACCTGAACTGTG	0.418		NA											22	74					0	0	0	0
MTRR	4552	broad.mit.edu	37	5	7897181	7897181	+	Silent	SNP	A	A	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:7897181A>G	uc003jed.2	+	14	1884	c.1854A>G	c.(1852-1854)AAA>AAG	p.K618K	MTRR_uc003jee.3_Silent_p.K591K|MTRR_uc003jef.3_RNA|MTRR_uc003jeg.3_RNA|MTRR_uc010ito.2_RNA	NM_024010	NP_076915	Q9UBK8	MTRR_HUMAN	methionine synthase reductase isoform 2	618					methionine biosynthetic process	cytosol	[methionine synthase] reductase activity|flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding			ovary(1)	1					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)|L-Methionine(DB00134)	ATTTCAGAAAAGAGCTCAGAC	0.388		NA											15	20					0	0	0	0
SEMA5A	9037	broad.mit.edu	37	5	9202224	9202224	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:9202224C>A	uc003jek.2	-	9	1487	c.775G>T	c.(775-777)GGT>TGT	p.G259C		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	259	Sema.|Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						AAGCGCCCACCAATATCGTTC	0.507		NA											30	59					4.03e-09	5.04e-09	1	0
PRDM9	56979	broad.mit.edu	37	5	23522738	23522738	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:23522738A>G	uc003jgo.2	+	8	808	c.626A>G	c.(625-627)CAG>CGG	p.Q209R		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	209					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						GAGATGTGTCAGAACTTCTTC	0.483		NA								HNSCC(3;0.000094)			20	15					0	0	0	0
CDH6	1004	broad.mit.edu	37	5	31323142	31323142	+	Silent	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:31323142C>A	uc003jhe.1	+	12	2426	c.2100C>A	c.(2098-2100)CCC>CCA	p.P700P		NM_004932	NP_004923	P55285	CADH6_HUMAN	cadherin 6, type 2 preproprotein	700	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			ovary(4)|skin(2)|large_intestine(1)	7						TTTTCCTACCCCGACGGACTC	0.517		NA											15	50					0.000308642	0.000338576	1	0
TARS	6897	broad.mit.edu	37	5	33461070	33461070	+	Silent	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:33461070G>A	uc003jhy.2	+	12	1609	c.1314G>A	c.(1312-1314)GGG>GGA	p.G438G	TARS_uc011cob.1_Silent_p.G426G|TARS_uc010iup.1_Silent_p.G379G|TARS_uc011coc.1_Silent_p.G459G|TARS_uc003jhz.2_Silent_p.G334G|TARS_uc011cod.1_Silent_p.G317G	NM_152295	NP_689508	P26639	SYTC_HUMAN	threonyl-tRNA synthetase	438					threonyl-tRNA aminoacylation	cytosol	ATP binding|protein homodimerization activity|threonine-tRNA ligase activity			ovary(2)	2					L-Threonine(DB00156)	CTGATTTTGGGGTACTTCATA	0.502		NA											18	48					0	0	0	0
SPEF2	79925	broad.mit.edu	37	5	35654802	35654802	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:35654802C>T	uc003jjo.2	+	7	1063	c.952C>T	c.(952-954)CAG>TAG	p.Q318*	SPEF2_uc003jjn.1_Nonsense_Mutation_p.Q318*|SPEF2_uc003jjq.3_Nonsense_Mutation_p.Q318*	NM_024867	NP_079143	Q9C093	SPEF2_HUMAN	KPL2 protein isoform 1	318					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GTTAATGGACCAGTTAATAGC	0.383		NA											45	43					0	0	0	0
SKP2	6502	broad.mit.edu	37	5	36184011	36184011	+	Silent	SNP	T	T	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:36184011T>G	uc003jkd.2	+	10	1307	c.1131T>G	c.(1129-1131)ACT>ACG	p.T377T		NM_032637	NP_116026	Q13309	SKP2_HUMAN	S-phase kinase-associated protein 2 isoform 2	Error:Variant_position_missing_in_Q13309_after_alignment					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|G1/S transition of mitotic cell cycle|S phase of mitotic cell cycle	nucleoplasm|SCF ubiquitin ligase complex	protein binding			central_nervous_system(2)|ovary(1)|breast(1)	4	all_lung(31;5.63e-05)		Epithelial(62;0.0396)|Lung(74;0.111)|all cancers(62;0.115)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CATACAGAACTTCCAAACTCA	0.363		NA											7	71					0	0	0	0
PTGER4	5734	broad.mit.edu	37	5	40681505	40681505	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:40681505G>T	uc003jlz.2	+	2	1002	c.410G>T	c.(409-411)GGC>GTC	p.G137V		NM_000958	NP_000949	P35408	PE2R4_HUMAN	prostaglandin E receptor 4, subtype EP4	137	Helical; Name=4; (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger|immune response	integral to membrane|plasma membrane	prostaglandin E receptor activity			lung(2)	2						CGATTGGCGGGCCTCACGCTC	0.597		NA									OREG0016588	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	58	74					9.6e-30	1.46e-29	1	0
HEATR7B2	133558	broad.mit.edu	37	5	41038946	41038946	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:41038946C>A	uc003jmj.3	-	21	2596	c.2106G>T	c.(2104-2106)ATG>ATT	p.M702I	HEATR7B2_uc003jmi.3_Missense_Mutation_p.M257I	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	702							binding			ovary(6)|central_nervous_system(2)	8						CATAGATGACCATGACATCTG	0.453		NA											19	57					7.42e-09	9.23e-09	1	0
MGC42105	167359	broad.mit.edu	37	5	43280809	43280809	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:43280809C>G	uc003jno.2	+	4	2170	c.1289C>G	c.(1288-1290)TCC>TGC	p.S430C		NM_153361	NP_699192	Q8IY84	NIM1_HUMAN	serine/threonine-protein kinase NIM1	430							ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(4)|ovary(2)|stomach(1)|large_intestine(1)|breast(1)	9						AGACACACATCCAAATTTTGC	0.403		NA											25	33					0	0	0	0
CCL28	56477	broad.mit.edu	37	5	43382139	43382139	+	Silent	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:43382139G>T	uc003jnu.2	-	3	277	c.207C>A	c.(205-207)CGC>CGA	p.R69R	CCL28_uc003jns.2_RNA|CCL28_uc003jnt.2_RNA|CCL28_uc010ivn.2_Silent_p.R22R	NM_148672	NP_683513	Q9NRJ3	CCL28_HUMAN	chemokine (C-C motif) ligand 28 precursor	69					chemotaxis|immune response	extracellular space	chemokine activity			ovary(1)|kidney(1)	2						AGATTCTTCTGCGCTTGACAT	0.398		NA											12	60					6.4e-05	7.16e-05	1	0
MAP1B	4131	broad.mit.edu	37	5	71492252	71492252	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:71492252G>A	uc003kbw.3	+	5	3311	c.3070G>A	c.(3070-3072)GAC>AAC	p.D1024N	MAP1B_uc010iyw.1_Missense_Mutation_p.D1041N|MAP1B_uc010iyx.1_Missense_Mutation_p.D898N|MAP1B_uc010iyy.1_Missense_Mutation_p.D898N	NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	1024						microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		TGATGAGGAGGACAAAGCTGA	0.532		NA											37	11					0	0	0	0
AP3B1	8546	broad.mit.edu	37	5	77385258	77385258	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:77385258G>T	uc003kfj.2	-	22	2661	c.2536C>A	c.(2536-2538)CTT>ATT	p.L846I		NM_003664	NP_003655	O00203	AP3B1_HUMAN	adaptor-related protein complex 3, beta 1	846					endocytosis|melanosome organization	clathrin coated vesicle membrane|Golgi apparatus|membrane coat	protein phosphatase binding|protein transporter activity			central_nervous_system(1)	1		all_lung(232;0.000397)|Lung NSC(167;0.00106)|Ovarian(174;0.0105)|Prostate(461;0.215)		OV - Ovarian serous cystadenocarcinoma(54;8.23e-47)|Epithelial(54;2.74e-41)|all cancers(79;4.8e-36)		AAACCTTCAAGATCAGCCATC	0.393		NA							Hermansky-Pudlak_syndrome				28	14					1.55e-18	2.2e-18	1	0
NR2F1	7025	broad.mit.edu	37	5	92923837	92923837	+	Silent	SNP	G	G	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:92923837G>C	uc003kkj.2	+	2	2365	c.678G>C	c.(676-678)CTG>CTC	p.L226L		NM_005654	NP_005645	P10589	COT1_HUMAN	nuclear receptor subfamily 2, group F, member 1	226					negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	ligand-regulated transcription factor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding			urinary_tract(1)|ovary(1)|lung(1)	3		all_cancers(142;1.62e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0126)|Lung NSC(167;0.0155)|Ovarian(174;0.0218)|Prostate(281;0.173)|Colorectal(57;0.19)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0416)|all cancers(79;9.57e-18)		CCGCGCGCCTGCTCTTCAGCG	0.652		NA											40	28					0	0	0	0
TRIM36	55521	broad.mit.edu	37	5	114472790	114472790	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:114472790A>G	uc003kqs.2	-	7	1662	c.1153T>C	c.(1153-1155)TTT>CTT	p.F385L	TRIM36_uc011cwc.1_Missense_Mutation_p.F373L|TRIM36_uc003kqt.2_Missense_Mutation_p.F230L	NM_018700	NP_061170	Q9NQ86	TRI36_HUMAN	tripartite motif-containing 36 isoform 1	385	COS.					acrosomal vesicle|cytoskeleton	ligase activity|zinc ion binding			ovary(4)|lung(2)|breast(2)	8		all_cancers(142;0.00133)|all_epithelial(76;2.41e-05)|Prostate(80;0.00955)|Ovarian(225;0.0443)|Breast(839;0.195)		OV - Ovarian serous cystadenocarcinoma(64;3.62e-08)|Epithelial(69;7.69e-08)|all cancers(49;9.33e-06)		GCAGGTCTAAAGCTCTTCAAA	0.333		NA											12	13					0	0	0	0
P4HA2	8974	broad.mit.edu	37	5	131533904	131533904	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:131533904T>A	uc003kwh.2	-	12	1930	c.1366A>T	c.(1366-1368)AAC>TAC	p.N456Y	P4HA2_uc003kwg.2_Intron|P4HA2_uc003kwi.2_Intron|P4HA2_uc003kwk.2_Intron|P4HA2_uc003kwl.2_Missense_Mutation_p.N456Y|P4HA2_uc003kwj.2_Intron	NM_004199	NP_004190	O15460	P4HA2_HUMAN	prolyl 4-hydroxylase, alpha II subunit isoform 1	456	Fe2OG dioxygenase.					endoplasmic reticulum lumen	electron carrier activity|iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 4-dioxygenase activity|protein binding				0		all_cancers(142;0.103)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Proline(DB00172)|Succinic acid(DB00139)	CTCACGTAGTTTAAGAAAGTA	0.502		NA											31	11					0	0	0	0
GFRA3	2676	broad.mit.edu	37	5	137593402	137593402	+	Silent	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:137593402G>T	uc003lcn.2	-	4	851	c.711C>A	c.(709-711)CCC>CCA	p.P237P	GFRA3_uc003lco.2_Silent_p.P206P	NM_001496	NP_001487	O60609	GFRA3_HUMAN	GDNF family receptor alpha 3 preproprotein	237					peripheral nervous system development	anchored to membrane|cytoplasm|extrinsic to membrane|intracellular membrane-bounded organelle	receptor binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			GCGCGCAGTTGGGGGCGATGG	0.711		NA											16	6					3.53e-06	4.11e-06	1	0
NRG2	9542	broad.mit.edu	37	5	139231313	139231313	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:139231313G>T	uc003lex.1	-	9	1873	c.1648C>A	c.(1648-1650)CCA>ACA	p.P550T	NRG2_uc003lev.1_Missense_Mutation_p.P558T|NRG2_uc003lew.1_Missense_Mutation_p.P552T|NRG2_uc003ley.1_Missense_Mutation_p.P544T	NM_004883	NP_004874	O14511	NRG2_HUMAN	neuregulin 2 isoform 1	550	Cytoplasmic (Potential).				embryo development	extracellular region|integral to membrane|plasma membrane	growth factor activity			pancreas(2)|breast(2)|ovary(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACACATGCTGGGCTGTTGCAT	0.627		NA											7	25					0.00198382	0.00212623	1	0
PCDHA4	56144	broad.mit.edu	37	5	140188217	140188217	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:140188217C>A	uc003lhi.2	+	1	1546	c.1445C>A	c.(1444-1446)GCG>GAG	p.A482E	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhh.1_Missense_Mutation_p.A482E|PCDHA4_uc011daa.1_Missense_Mutation_p.A482E	NM_018907	NP_061730	Q9UN74	PCDA4_HUMAN	protocadherin alpha 4 isoform 1 precursor	482	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGTGGGACGCGGACGCGCAG	0.657		NA											36	28					1.71e-08	2.12e-08	1	0
PCDHA4	56144	broad.mit.edu	37	5	140188563	140188563	+	Silent	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:140188563G>A	uc003lhi.2	+	1	1892	c.1791G>A	c.(1789-1791)GTG>GTA	p.V597V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhh.1_Silent_p.V597V|PCDHA4_uc011daa.1_Silent_p.V597V	NM_018907	NP_061730	Q9UN74	PCDA4_HUMAN	protocadherin alpha 4 isoform 1 precursor	597	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCGCGCGGTGGATGCTGACT	0.692		NA											41	21					0	0	0	0
PCDHA6	56142	broad.mit.edu	37	5	140209620	140209620	+	Silent	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:140209620G>T	uc003lho.2	+	1	1971	c.1944G>T	c.(1942-1944)CTG>CTT	p.L648L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc011dab.1_Silent_p.L648L	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	648	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACCGGCTGCTGGTGCTGGTGA	0.667		NA											37	16					3.66e-26	5.52e-26	1	0
PCDHA12	56137	broad.mit.edu	37	5	140257259	140257259	+	Silent	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:140257259G>T	uc003lic.2	+	1	2329	c.2202G>T	c.(2200-2202)CCG>CCT	p.P734P	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc011daf.1_Silent_p.P734P	NM_018903	NP_061726	Q9UN75	PCDAC_HUMAN	protocadherin alpha 12 isoform 1 precursor	734	5 X 4 AA repeats of P-X-X-P.|Cytoplasmic (Potential).|PXXP 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTGCGCGCCGGGCAAGCCCA	0.682		NA											13	2					4.37e-10	5.55e-10	1	0
PCDHGA1	56114	broad.mit.edu	37	5	140712446	140712446	+	Nonsense_Mutation	SNP	T	T	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:140712446T>A	uc003lji.1	+	1	2195	c.2195T>A	c.(2194-2196)TTA>TAA	p.L732*	PCDHGA1_uc011dan.1_Nonsense_Mutation_p.L732*	NM_018912	NP_061735	Q9Y5H4	PCDG1_HUMAN	protocadherin gamma subfamily A, 1 isoform 1	732	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|breast(1)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGAGGCGGCTTAGCGAGCATG	0.652		NA											50	35					0	0	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140720611	140720611	+	Silent	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:140720611G>T	uc003ljk.1	+	1	2258	c.2073G>T	c.(2071-2073)CTG>CTT	p.L691L	PCDHGA1_uc003lji.1_Intron|PCDHGA3_uc003ljm.1_5'Flank|PCDHGA3_uc010jfx.1_5'Flank|PCDHGA2_uc011dao.1_Silent_p.L691L|PCDHGA3_uc011dap.1_5'Flank	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	691	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACCTCACTCTGTACCTGGTGG	0.677		NA											84	53					1.53e-57	2.39e-57	1	0
PCDHGB6	56100	broad.mit.edu	37	5	140789266	140789267	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:140789266_140789267GG>TT	uc003lkj.1	+	1	1497_1498	c.1497_1498GG>TT	c.(1495-1500)CTGGCG>CTTTCG	p.A500S	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lki.1_Missense_Mutation_p.A500S	NM_018926	NP_061749	Q9Y5F9	PCDGI_HUMAN	protocadherin gamma subfamily B, 6 isoform 1	500	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TAGAGCCCCTGGCGGTGTCGTC	0.639		NA											15	7					0	0	0	0
PCDHGA12	26025	broad.mit.edu	37	5	140811002	140811002	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:140811002G>A	uc003lkt.1	+	1	845	c.676G>A	c.(676-678)GCG>ACG	p.A226T	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc011dba.1_Missense_Mutation_p.A226T	NM_003735	NP_003726	O60330	PCDGC_HUMAN	protocadherin gamma subfamily A, 12 isoform 1	226	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACAGGCACCGCGCGCATCCG	0.657		NA											33	12					0	0	0	0
ZNF300	91975	broad.mit.edu	37	5	150275854	150275854	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:150275854T>C	uc003lsy.1	-	6	1214	c.947A>G	c.(946-948)CAG>CGG	p.Q316R	IRGM_uc011dcl.1_Intron	NM_052860	NP_443092	Q96RE9	ZN300_HUMAN	zinc finger protein 300	316	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2		Medulloblastoma(196;0.109)|all_hematologic(541;0.131)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ATGAGTTCTCTGATGTACAAC	0.398		NA											69	43					0	0	0	0
GRIA1	2890	broad.mit.edu	37	5	153077675	153077675	+	Silent	SNP	A	A	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:153077675A>T	uc003lva.3	+	9	1571	c.1206A>T	c.(1204-1206)TCA>TCT	p.S402S	GRIA1_uc003luy.3_Silent_p.S402S|GRIA1_uc003luz.3_Silent_p.S307S|GRIA1_uc011dcv.1_RNA|GRIA1_uc011dcw.1_Silent_p.S322S|GRIA1_uc011dcx.1_Silent_p.S333S|GRIA1_uc011dcy.1_Silent_p.S412S|GRIA1_uc011dcz.1_Silent_p.S412S|GRIA1_uc010jia.1_Silent_p.S382S	NM_001114183	NP_001107655	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1 isoform	402	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			ovary(4)|skin(2)	6		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	GCGATAATTCAAGTGTTCAGA	0.458		NA											16	15					0	0	0	0
SGCD	6444	broad.mit.edu	37	5	156184595	156184595	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:156184595G>T	uc003lwd.3	+	7	1052	c.576G>T	c.(574-576)TTG>TTT	p.L192F	SGCD_uc003lwb.2_Missense_Mutation_p.L193F|SGCD_uc003lwc.3_Missense_Mutation_p.L193F	NM_001128209	NP_001121681	Q92629	SGCD_HUMAN	delta-sarcoglycan isoform 3	192	Extracellular (Potential).				cytoskeleton organization|muscle organ development	cytoplasm|cytoskeleton|integral to membrane|sarcoglycan complex|sarcolemma					0	Renal(175;0.00488)	Medulloblastoma(196;0.0378)|all_neural(177;0.106)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TTTTCAGGTTGGAGTCCCCAA	0.443		NA											9	2					2.81e-09	3.52e-09	1	0
C5orf54	63920	broad.mit.edu	37	5	159821207	159821207	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:159821207C>A	uc003lye.1	-	2	1755	c.1291G>T	c.(1291-1293)GAA>TAA	p.E431*	C5orf54_uc003lyf.1_Nonsense_Mutation_p.E431*	NM_022090	NP_071373	Q8IZ13	CE054_HUMAN	transposon-derived Buster3 transposase-like	431										pancreas(1)	1						attatttcttcaagaaaagga	0		NA											38	20					1.41e-09	1.78e-09	1	0
ATP10B	23120	broad.mit.edu	37	5	160029629	160029629	+	Silent	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:160029629G>A	uc003lym.1	-	21	4165	c.3318C>T	c.(3316-3318)TAC>TAT	p.Y1106Y	ATP10B_uc010jit.1_Silent_p.Y423Y	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	1106	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CCAGGCGCGAGTAACACCAGT	0.567		NA											22	10					0	0	0	0
ATP10B	23120	broad.mit.edu	37	5	160033898	160033898	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:160033898C>A	uc003lym.1	-	19	3881	c.3034G>T	c.(3034-3036)GAG>TAG	p.E1012*	ATP10B_uc010jit.1_Nonsense_Mutation_p.E329*	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	1012	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AACTTCTTCTCTAGCTTTCCC	0.507		NA											51	40					4.86e-25	7.28e-25	1	0
ODZ2	57451	broad.mit.edu	37	5	167655022	167655022	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:167655022A>G	uc010jjd.2	+	25	5380	c.5380A>G	c.(5380-5382)ATT>GTT	p.I1794V	ODZ2_uc003lzr.3_Missense_Mutation_p.I1564V|ODZ2_uc003lzt.3_Missense_Mutation_p.I1167V|ODZ2_uc010jje.2_Missense_Mutation_p.I1058V	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		CACCCCCACCATTGGACGCTG	0.512		NA											14	5					0	0	0	0
HK3	3101	broad.mit.edu	37	5	176318482	176318482	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:176318482C>G	uc003mfa.2	-	3	258	c.166G>C	c.(166-168)GGT>CGT	p.G56R	HK3_uc003mez.2_5'Flank	NM_002115	NP_002106	P52790	HXK3_HUMAN	hexokinase 3	56	Regulatory.				glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity			ovary(3)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)|skin(1)	7	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TCCATGGAACCCAAGAGGCTG	0.627		NA											30	28					0	0	0	0
ZNF346	23567	broad.mit.edu	37	5	176489129	176489129	+	Silent	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:176489129C>T	uc003mfi.2	+	6	817	c.774C>T	c.(772-774)GTC>GTT	p.V258V	ZNF346_uc011dfr.1_Silent_p.V226V|ZNF346_uc011dfs.1_Silent_p.V160V|ZNF346_uc003mfj.2_Silent_p.V82V|ZNF346_uc003mfk.1_Silent_p.V283V|ZNF346_uc011dft.1_Silent_p.V82V	NM_012279	NP_036411	Q9UL40	ZN346_HUMAN	zinc finger protein 346	258	Matrin-type 4.					cytoplasm|nucleolus	double-stranded RNA binding|zinc ion binding				0	all_cancers(89;6.3e-05)|Renal(175;0.000269)|Lung NSC(126;0.00476)|all_lung(126;0.00806)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AAGCTCATGTCAGCGGCTTCA	0.408		NA											66	48					0	0	0	0
ADAMTS2	9509	broad.mit.edu	37	5	178770807	178770807	+	Silent	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr5:178770807G>A	uc003mjw.2	-	2	495	c.495C>T	c.(493-495)GCC>GCT	p.A165A	ADAMTS2_uc011dgm.1_Silent_p.A165A	NM_014244	NP_055059	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1	165					collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		AGGAGGCTTCGGCTAGGCCGG	0.652		NA											6	8					0	0	0	0
JARID2	3720	broad.mit.edu	37	6	15468903	15468903	+	Silent	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:15468903G>T	uc003nbj.2	+	5	868	c.624G>T	c.(622-624)TCG>TCT	p.S208S	JARID2_uc011diu.1_Silent_p.S72S|JARID2_uc011div.1_Silent_p.S36S|JARID2_uc011diw.1_Silent_p.S170S	NM_004973	NP_004964	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2 protein	208					central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			ovary(2)|lung(1)|pancreas(1)	4	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				CATGCCAGTCGACCCCCAGGA	0.468		NA											37	57					3.72e-46	5.78e-46	1	0
OR2B6	26212	broad.mit.edu	37	6	27925284	27925284	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:27925284G>A	uc011dkx.1	+	1	266	c.266G>A	c.(265-267)AGG>AAG	p.R89K		NM_012367	NP_036499	P58173	OR2B6_HUMAN	olfactory receptor, family 2, subfamily B,	89	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TGCAGCATCAGGAAAGTAATC	0.428		NA											30	16					0	0	0	0
COL11A2	1302	broad.mit.edu	37	6	33146751	33146751	+	Splice_Site	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:33146751C>A	uc003ocx.1	-	17	1840	c.1612_splice	c.e17-1	p.G538_splice	COL11A2_uc010jul.1_5'Flank|COL11A2_uc003ocy.1_Splice_Site_p.G452_splice|COL11A2_uc003ocz.1_Splice_Site_p.G431_splice	NM_080680	NP_542411	P13942	COBA2_HUMAN	collagen, type XI, alpha 2 isoform 1						cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			ovary(3)|skin(2)	5						CTGCCCGGCCCTGGGAGAACA	0.647		NA											16	11					0.00400662	0.00426668	1	0
RGL2	5863	broad.mit.edu	37	6	33264212	33264212	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:33264212T>C	uc003odv.2	-	5	582	c.449A>G	c.(448-450)GAC>GGC	p.D150G	RGL2_uc003odu.2_5'Flank|RGL2_uc010jur.2_5'UTR|RGL2_uc003odw.2_Missense_Mutation_p.D68G|RGL2_uc011drb.1_Missense_Mutation_p.D68G	NM_004761	NP_004752	O15211	RGL2_HUMAN	ral guanine nucleotide dissociation	150	N-terminal Ras-GEF.				Ras protein signal transduction|regulation of small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity			skin(3)|lung(1)|breast(1)|pancreas(1)	6						CTCTAGTTCGTCGGTAGGATG	0.522		NA											33	18					0	0	0	0
LRFN2	57497	broad.mit.edu	37	6	40399511	40399511	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:40399511G>A	uc003oph.1	-	2	1807	c.1342C>T	c.(1342-1344)CGG>TGG	p.R448W		NM_020737	NP_065788	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III	448	Fibronectin type-III.|Extracellular (Potential).					cell junction|integral to membrane|postsynaptic membrane				ovary(2)|skin(1)	3	Ovarian(28;0.0418)|Colorectal(47;0.196)					ATCTTCACCCGGGGTGCTGAC	0.592		NA											11	37					0	0	0	0
TFEB	7942	broad.mit.edu	37	6	41653831	41653831	+	Silent	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:41653831G>T	uc003oqs.1	-	9	1250	c.948C>A	c.(946-948)ATC>ATA	p.I316I	TFEB_uc003oqt.1_Silent_p.I316I|TFEB_uc003oqu.1_Silent_p.I330I|TFEB_uc003oqr.1_Silent_p.I231I	NM_007162	NP_009093	P19484	TFEB_HUMAN	transcription factor EB	316	Leucine-zipper.				embryonic placenta development|humoral immune response|positive regulation of transcription from RNA polymerase II promoter	cytoplasm	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(1)	1	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;7.61e-05)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00507)			ACCAGACCTGGATACGGAGCC	0.537		NA	T	ALPHA	renal (childhood epithelioid)								15	61					3.41e-10	4.34e-10	1	0
CUL7	9820	broad.mit.edu	37	6	43020081	43020081	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:43020081C>T	uc003otq.2	-	2	749	c.446G>A	c.(445-447)AGC>AAC	p.S149N	CUL7_uc011dvb.1_Missense_Mutation_p.S201N|CUL7_uc010jyh.2_Intron|KLC4_uc003otr.1_Intron	NM_014780	NP_055595	Q14999	CUL7_HUMAN	cullin 7	149					interspecies interaction between organisms|ubiquitin-dependent protein catabolic process|vasculogenesis	anaphase-promoting complex|mitochondrion	ubiquitin protein ligase binding			ovary(3)|kidney(1)	4			all cancers(41;0.00231)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			GGGCTCAATGCTGGCATAGGC	0.557		NA											4	35					0	0	0	0
PTK7	5754	broad.mit.edu	37	6	43109969	43109969	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:43109969G>T	uc003oub.1	+	13	2177	c.1979G>T	c.(1978-1980)GGC>GTC	p.G660V	PTK7_uc003ouc.1_Intron|PTK7_uc003oud.1_Missense_Mutation_p.G620V|PTK7_uc003oue.1_Missense_Mutation_p.G530V|PTK7_uc003ouf.1_RNA|PTK7_uc003oug.1_RNA|PTK7_uc011dve.1_Missense_Mutation_p.G668V|PTK7_uc010jyj.1_Intron	NM_002821	NP_002812	Q13308	PTK7_HUMAN	PTK7 protein tyrosine kinase 7 isoform a	660	Ig-like C2-type 7.|Extracellular (Potential).				actin cytoskeleton reorganization|canonical Wnt receptor signaling pathway|cell adhesion|cell migration	cell-cell junction|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			ovary(2)|large_intestine(1)	3			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00784)|OV - Ovarian serous cystadenocarcinoma(102;0.0423)			GAGGACTCAGGCCGCTACACC	0.607		NA											27	40					4.75e-14	6.43e-14	1	0
TINAG	27283	broad.mit.edu	37	6	54191661	54191661	+	Missense_Mutation	SNP	C	C	T	rs115438249	byFrequency	TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:54191661C>T	uc003pcj.2	+	4	717	c.571C>T	c.(571-573)CGC>TGC	p.R191C	TINAG_uc010jzt.2_RNA	NM_014464	NP_055279	Q9UJW2	TINAG_HUMAN	tubulointerstitial nephritis antigen	191					cell adhesion|immune response|Malpighian tubule morphogenesis|proteolysis	basement membrane	cysteine-type endopeptidase activity|nucleotide binding|polysaccharide binding|scavenger receptor activity			ovary(3)|central_nervous_system(1)	4	Lung NSC(77;0.0518)		LUSC - Lung squamous cell carcinoma(124;0.246)			TTTTAAATTTCGCCTTGGCAC	0.373		NA											26	38					0	0	0	0
TINAG	27283	broad.mit.edu	37	6	54214671	54214671	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:54214671C>A	uc003pcj.2	+	7	1203	c.1057C>A	c.(1057-1059)CCT>ACT	p.P353T	TINAG_uc010jzt.2_RNA	NM_014464	NP_055279	Q9UJW2	TINAG_HUMAN	tubulointerstitial nephritis antigen	353					cell adhesion|immune response|Malpighian tubule morphogenesis|proteolysis	basement membrane	cysteine-type endopeptidase activity|nucleotide binding|polysaccharide binding|scavenger receptor activity			ovary(3)|central_nervous_system(1)	4	Lung NSC(77;0.0518)		LUSC - Lung squamous cell carcinoma(124;0.246)			TCAATGTTCTCCTCCATACAG	0.408		NA											11	51					7.93e-07	9.38e-07	1	0
PRIM2	5558	broad.mit.edu	37	6	57512611	57512611	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:57512611C>T	uc003pdx.2	+	15	1526	c.1439C>T	c.(1438-1440)ACC>ATC	p.T480I		NM_000947	NP_000938	P49643	PRI2_HUMAN	DNA primase polypeptide 2	480					DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	4 iron, 4 sulfur cluster binding|DNA binding|DNA primase activity|metal ion binding				0				Colorectal(6;0.041)|READ - Rectum adenocarcinoma(7;0.193)		GTCCAGAAAACCAAGGATGCA	0.403		NA											60	373					0	0	0	0
DDX43	55510	broad.mit.edu	37	6	74116174	74116174	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:74116174C>A	uc003pgw.2	+	7	1239	c.895C>A	c.(895-897)CCT>ACT	p.P299T	DDX43_uc011dyn.1_RNA	NM_018665	NP_061135	Q9NXZ2	DDX43_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 43	299	Helicase ATP-binding.					intracellular	ATP binding|ATP-dependent RNA helicase activity|RNA binding			ovary(2)|upper_aerodigestive_tract(1)|skin(1)	4						TTATTTAATGCCTGGATTTAT	0.378		NA											23	20					9.58e-11	1.23e-10	1	0
FUT9	10690	broad.mit.edu	37	6	96651708	96651708	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:96651708T>A	uc003pop.3	+	3	1018	c.677T>A	c.(676-678)GTC>GAC	p.V226D		NM_006581	NP_006572	Q9Y231	FUT9_HUMAN	fucosyltransferase 9 (alpha (1,3)	226	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			skin(4)|ovary(1)	5		all_cancers(76;4.77e-07)|Acute lymphoblastic leukemia(125;4.01e-09)|all_hematologic(75;1.25e-06)|all_epithelial(107;0.00279)|Colorectal(196;0.0356)		BRCA - Breast invasive adenocarcinoma(108;0.08)		GGAGAATATGTCAATGATAAA	0.353		NA											8	20					0	0	0	0
LIN28B	389421	broad.mit.edu	37	6	105406156	105406156	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:105406156C>G	uc003pqv.1	+	2	396	c.193C>G	c.(193-195)CAC>GAC	p.H65D	LIN28B_uc010kda.1_Missense_Mutation_p.H25D	NM_001004317	NP_001004317	Q6ZN17	LN28B_HUMAN	lin-28 homolog B	65	CSD.				miRNA catabolic process|pre-miRNA processing|regulation of transcription, DNA-dependent|RNA 3'-end processing	cytoplasm|nucleus	DNA binding|protein binding|RNA binding|zinc ion binding				0		all_cancers(87;0.00346)|Acute lymphoblastic leukemia(125;2.26e-08)|all_hematologic(75;2.79e-06)|all_epithelial(87;0.204)				TGTATTTGTACACCAAGTAAG	0.453		NA											36	56					0	0	0	0
C6orf203	51250	broad.mit.edu	37	6	107361208	107361208	+	Missense_Mutation	SNP	G	G	A	rs150832095	byFrequency	TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:107361208G>A	uc003prq.2	+	2	325	c.244G>A	c.(244-246)GTA>ATA	p.V82I	C6orf203_uc011eaj.1_Missense_Mutation_p.V87I|C6orf203_uc010kde.2_Missense_Mutation_p.V82I	NM_016487	NP_057571	Q9P0P8	CF203_HUMAN	hypothetical protein LOC51250 isoform a	82											0	Breast(9;0.00124)|all_epithelial(6;0.0729)	all_cancers(87;0.00461)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|Colorectal(196;0.171)|all_epithelial(87;0.23)	BRCA - Breast invasive adenocarcinoma(8;0.000395)|all cancers(7;0.00065)|Epithelial(6;0.000834)|OV - Ovarian serous cystadenocarcinoma(5;0.244)	BRCA - Breast invasive adenocarcinoma(108;0.117)		TCCTTTTTCCGTAAGACTCAA	0.333		NA											25	55					0	0	0	0
GPR6	2830	broad.mit.edu	37	6	110301114	110301114	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:110301114G>T	uc011eaw.1	+	2	979	c.799G>T	c.(799-801)GCG>TCG	p.A267S	GPR6_uc011eav.1_Missense_Mutation_p.A282S|GPR6_uc003ptu.2_Missense_Mutation_p.A267S	NM_005284	NP_005275	P46095	GPR6_HUMAN	G protein-coupled receptor 6	267	Cytoplasmic (Potential).					integral to plasma membrane					0		all_cancers(87;1.64e-05)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;2.83e-05)|all_lung(197;0.00016)|Lung NSC(302;0.000318)|Colorectal(196;0.0488)		BRCA - Breast invasive adenocarcinoma(108;8.01e-05)|Epithelial(106;8.76e-05)|all cancers(137;0.000197)|OV - Ovarian serous cystadenocarcinoma(136;0.0307)		GCACTGCCTGGCGCCACCCCA	0.637		NA											7	37					5.49e-09	6.85e-09	1	0
ROS1	6098	broad.mit.edu	37	6	117665282	117665282	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:117665282C>A	uc003pxp.1	-	27	4664	c.4465G>T	c.(4465-4467)GTT>TTT	p.V1489F	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	1489	Extracellular (Potential).|Fibronectin type-III 6.				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		GCATAATAAACCAGGTATGTT	0.398		NA	T	GOPC|ROS1	glioblastoma|NSCLC								17	32					5.35e-07	6.37e-07	1	0
LAMA2	3908	broad.mit.edu	37	6	129704301	129704301	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:129704301G>T	uc003qbn.2	+	35	5099	c.4994G>T	c.(4993-4995)GGA>GTA	p.G1665V	LAMA2_uc003qbo.2_Missense_Mutation_p.G1665V	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1665	Domain II and I.|Potential.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		GAGCAGACCGGACAGGATGCT	0.448		NA											10	17					0.000978159	0.00105749	1	0
MOXD1	26002	broad.mit.edu	37	6	132722446	132722446	+	Silent	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:132722446G>T	uc003qdf.2	-	1	219	c.120C>A	c.(118-120)GGC>GGA	p.G40G		NM_015529	NP_056344	Q6UVY6	MOXD1_HUMAN	monooxygenase, DBH-like 1 isoform 2	40	Lumenal (Potential).|DOMON.				catecholamine metabolic process	endoplasmic reticulum membrane|integral to membrane	copper ion binding|dopamine beta-monooxygenase activity			ovary(1)	1	Breast(56;0.0495)			OV - Ovarian serous cystadenocarcinoma(155;0.0132)|GBM - Glioblastoma multiforme(226;0.0191)		GCTGGCTCCAGCCCAGCCAGT	0.736		NA											6	7					1.07e-07	1.29e-07	1	0
TAAR2	9287	broad.mit.edu	37	6	132938351	132938351	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:132938351C>T	uc003qdl.1	-	2	994	c.994G>A	c.(994-996)GGT>AGT	p.G332S	TAAR2_uc010kfr.1_Missense_Mutation_p.G287S	NM_001033080	NP_001028252	Q9P1P5	TAAR2_HUMAN	trace amine associated receptor 2 isoform 1	332	Cytoplasmic (Potential).					plasma membrane	G-protein coupled receptor activity			ovary(1)	1	Breast(56;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00608)|GBM - Glioblastoma multiforme(226;0.0151)		AAAATTTTACCTAGCAAAATG	0.343		NA											23	20					0	0	0	0
VNN2	8875	broad.mit.edu	37	6	133073775	133073775	+	Silent	SNP	A	A	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:133073775A>G	uc003qdt.2	-	4	662	c.651T>C	c.(649-651)TAT>TAC	p.Y217Y	VNN2_uc003qds.2_Intron|VNN2_uc010kgb.2_Intron|VNN2_uc003qdv.2_Silent_p.Y164Y	NM_004665	NP_004656	O95498	VNN2_HUMAN	vanin 2 isoform 1 precursor	217	CN hydrolase.				cellular component movement|pantothenate metabolic process	anchored to membrane|plasma membrane	pantetheine hydrolase activity				0				OV - Ovarian serous cystadenocarcinoma(155;0.00237)|GBM - Glioblastoma multiforme(226;0.0267)		CACCAGGATCATAGAAGAATA	0.443		NA											42	95					0	0	0	0
ALDH8A1	64577	broad.mit.edu	37	6	135239568	135239568	+	Silent	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:135239568G>T	uc003qew.2	-	7	1502	c.1449C>A	c.(1447-1449)ATC>ATA	p.I483I	ALDH8A1_uc003qex.2_Silent_p.I429I|ALDH8A1_uc010kgh.2_Silent_p.I261I|ALDH8A1_uc011ecx.1_Silent_p.I433I	NM_022568	NP_072090	Q9H2A2	AL8A1_HUMAN	aldehyde dehydrogenase 8A1 isoform 1	483					retinal metabolic process	cytoplasm	retinal dehydrogenase activity			ovary(2)|pancreas(1)|skin(1)	4	Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.00401)|GBM - Glioblastoma multiforme(68;0.0058)		GTTTAACGGTGATGGTTTTGA	0.478		NA											13	30					1.5e-05	1.71e-05	1	0
OLIG3	167826	broad.mit.edu	37	6	137814953	137814953	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:137814953G>C	uc003qhp.1	-	1	579	c.355C>G	c.(355-357)CGC>GGC	p.R119G		NM_175747	NP_786923	Q7RTU3	OLIG3_HUMAN	oligodendrocyte transcription factor 3	119	Helix-loop-helix motif.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0	Breast(32;0.165)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00161)|OV - Ovarian serous cystadenocarcinoma(155;0.00447)		GAGAGCTTGCGCACCGACGGC	0.602		NA											17	50					0	0	0	0
ULBP1	80329	broad.mit.edu	37	6	150290448	150290448	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:150290448T>C	uc003qnp.2	+	3	620	c.577T>C	c.(577-579)TGG>CGG	p.W193R		NM_025218	NP_079494	Q9BZM6	N2DL1_HUMAN	UL16 binding protein 1 precursor	193	MHC class I alpha-2 like.				antigen processing and presentation|immune response|natural killer cell activation|regulation of immune response	anchored to membrane|endoplasmic reticulum|MHC class I protein complex	MHC class I receptor activity			pancreas(1)	1		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.14e-11)		TTGTAAGATGTGGCTTGAAGA	0.448		NA											52	65					0	0	0	0
SYNE1	23345	broad.mit.edu	37	6	152652521	152652521	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:152652521G>T	uc010kiw.2	-	78	13901	c.13299C>A	c.(13297-13299)CAC>CAA	p.H4433Q	SYNE1_uc003qot.3_Missense_Mutation_p.H4362Q|SYNE1_uc003qou.3_Missense_Mutation_p.H4433Q|SYNE1_uc010kiz.2_Missense_Mutation_p.H188Q	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	4433	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GACAATTCACGTGGCTTTGTG	0.493		NA								HNSCC(10;0.0054)			35	29					9.81e-26	1.47e-25	1	0
RGS17	26575	broad.mit.edu	37	6	153347653	153347653	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:153347653C>A	uc003qpm.2	-	3	301	c.145G>T	c.(145-147)GGG>TGG	p.G49W		NM_012419	NP_036551	Q9UGC6	RGS17_HUMAN	regulator of G-protein signalling 17	49					negative regulation of signal transduction	cytoplasm|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			pancreas(1)	1		Ovarian(120;0.126)		OV - Ovarian serous cystadenocarcinoma(155;1.09e-09)|BRCA - Breast invasive adenocarcinoma(81;0.0429)		GCATTTTCCCCTCTTTCTTCA	0.398		NA							Lung_Cancer_Familial_Clustering_of				23	89					1.75e-13	2.34e-13	1	0
SYNJ2	8871	broad.mit.edu	37	6	158454617	158454617	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:158454617G>T	uc003qqx.1	+	4	691	c.616G>T	c.(616-618)GTC>TTC	p.V206F	SYNJ2_uc011efm.1_RNA|SYNJ2_uc003qqw.1_Missense_Mutation_p.V206F|SYNJ2_uc003qqy.1_5'UTR|SYNJ2_uc011efn.1_Missense_Mutation_p.V155F|SYNJ2_uc010kjo.1_Missense_Mutation_p.V155F	NM_003898	NP_003889	O15056	SYNJ2_HUMAN	synaptojanin 2	206	SAC.						nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(65;4.42e-18)|BRCA - Breast invasive adenocarcinoma(81;4.23e-05)		GGCCTGCCTCGTCTCTCGCGT	0.622		NA											23	32					4.72e-08	5.76e-08	1	0
PDE10A	10846	broad.mit.edu	37	6	165752772	165752772	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:165752772C>A	uc003qun.2	-	21	2384	c.2143G>T	c.(2143-2145)GGC>TGC	p.G715C	PDE10A_uc011egj.1_RNA|PDE10A_uc011egk.1_Missense_Mutation_p.G645C|PDE10A_uc003quo.2_Missense_Mutation_p.G725C	NM_006661	NP_006652	Q9Y233	PDE10_HUMAN	phosphodiesterase 10A isoform 2	715					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			ovary(3)|skin(2)	5		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	CATACCTGGCCTTGGGGGACT	0.353		NA											23	92					5.35e-11	6.91e-11	1	0
T	6862	broad.mit.edu	37	6	166581041	166581041	+	Silent	SNP	C	C	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:166581041C>G	uc003quu.1	-	2	532	c.39G>C	c.(37-39)CTG>CTC	p.L13L	T_uc003qut.1_Silent_p.L13L|T_uc003quv.1_Silent_p.L13L	NM_003181	NP_003172	O15178	BRAC_HUMAN	transcription factor T	13					anterior/posterior axis specification, embryo|mesoderm development|primitive streak formation	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2		Prostate(117;4.48e-07)|Ovarian(120;1.78e-06)|Breast(66;2.54e-06)|Lung SC(201;0.0225)|Esophageal squamous(34;0.0559)		OV - Ovarian serous cystadenocarcinoma(33;1.09e-113)|GBM - Glioblastoma multiforme(31;1.51e-108)|BRCA - Breast invasive adenocarcinoma(81;8.45e-09)|LUAD - Lung adenocarcinoma(999;0.0407)		CTCGGTACTGCAGGCTCTTTC	0.697		NA							Chordoma_Familial_Clustering_of				5	8					0	0	0	0
FRMD1	79981	broad.mit.edu	37	6	168457935	168457935	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:168457935G>T	uc003qwo.3	-	11	1557	c.1492C>A	c.(1492-1494)CCA>ACA	p.P498T	FRMD1_uc003qwm.3_Missense_Mutation_p.P292T|FRMD1_uc011egs.1_Missense_Mutation_p.P269T|FRMD1_uc011egt.1_Missense_Mutation_p.P433T|FRMD1_uc003qwn.3_Missense_Mutation_p.P430T	NM_024919	NP_079195	Q8N878	FRMD1_HUMAN	FERM domain containing 1 isoform 1	498						cytoskeleton	binding			ovary(1)	1		Breast(66;1.07e-05)|Ovarian(120;0.0728)		Epithelial(4;7.7e-30)|OV - Ovarian serous cystadenocarcinoma(33;5.82e-22)|BRCA - Breast invasive adenocarcinoma(4;1.38e-10)|GBM - Glioblastoma multiforme(31;0.000756)		GTGGGCGCTGGGTGCAGGGCC	0.672		NA											8	3					5.18e-06	6e-06	1	0
FRMD1	79981	broad.mit.edu	37	6	168464370	168464370	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:168464370C>A	uc003qwo.3	-	6	780	c.715G>T	c.(715-717)GGC>TGC	p.G239C	FRMD1_uc003qwm.3_Missense_Mutation_p.G10C|FRMD1_uc011egs.1_Missense_Mutation_p.G10C|FRMD1_uc011egt.1_Missense_Mutation_p.G151C|FRMD1_uc003qwn.3_Missense_Mutation_p.G171C	NM_024919	NP_079195	Q8N878	FRMD1_HUMAN	FERM domain containing 1 isoform 1	239	FERM.					cytoskeleton	binding			ovary(1)	1		Breast(66;1.07e-05)|Ovarian(120;0.0728)		Epithelial(4;7.7e-30)|OV - Ovarian serous cystadenocarcinoma(33;5.82e-22)|BRCA - Breast invasive adenocarcinoma(4;1.38e-10)|GBM - Glioblastoma multiforme(31;0.000756)		GGGCTCAGGCCCTGGCGCTCA	0.642		NA											15	31					1.03e-11	1.35e-11	1	0
DNAH11	8701	broad.mit.edu	37	7	21747362	21747362	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:21747362C>T	uc003svc.2	+	41	6644	c.6613C>T	c.(6613-6615)CCG>TCG	p.P2205S		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2205	AAA 2 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						GAAACAGAAGCCGGTTTGGAA	0.383		NA							Kartagener_syndrome				13	25					0	0	0	0
CCDC126	90693	broad.mit.edu	37	7	23682551	23682551	+	Silent	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:23682551G>T	uc003swl.2	+	4	697	c.240G>T	c.(238-240)GCG>GCT	p.A80A	CCDC126_uc003swm.2_Silent_p.A80A|CCDC126_uc003swn.2_Silent_p.A80A	NM_138771	NP_620126	Q96EE4	CC126_HUMAN	coiled-coil domain containing 126 precursor	80						extracellular region				ovary(1)|skin(1)	2						TTCCCCTAGCGGATCTGAAAA	0.368		NA											25	35					3.8e-18	5.33e-18	1	0
LOC402644	402644	broad.mit.edu	37	7	28318964	28318964	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:28318964C>A	uc010kuz.1	-	1	355	c.355G>T	c.(355-357)GGG>TGG	p.G119W		NM_001126493	NP_001119965			hypothetical protein LOC402644												0						CCAACCACCCCGTCTTGGCAG	0.468		NA											19	30					1.96e-10	2.51e-10	1	0
PDE1C	5137	broad.mit.edu	37	7	31864484	31864484	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:31864484G>C	uc003tcm.1	-	13	1872	c.1403C>G	c.(1402-1404)TCG>TGG	p.S468W	PDE1C_uc003tcn.1_Missense_Mutation_p.S468W|PDE1C_uc003tco.1_Missense_Mutation_p.S528W|PDE1C_uc003tcr.2_Missense_Mutation_p.S468W|PDE1C_uc003tcs.2_Missense_Mutation_p.S468W	NM_005020	NP_005011	Q14123	PDE1C_HUMAN	phosphodiesterase 1C	468	Catalytic (By similarity).				activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding	p.S468S(1)		skin(3)|central_nervous_system(1)	4			GBM - Glioblastoma multiforme(11;0.216)			CACTGACCTCGAACGCCTCTG	0.512		NA											42	94					0	0	0	0
BMPER	168667	broad.mit.edu	37	7	34009964	34009964	+	Silent	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:34009964G>A	uc011kap.1	+	5	540	c.426G>A	c.(424-426)GGG>GGA	p.G142G		NM_133468	NP_597725	Q8N8U9	BMPER_HUMAN	BMP-binding endothelial regulator precursor	142	VWFC 2.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				ovary(2)|central_nervous_system(1)	3						CAGAGTCTGGGGTGCGCTGTG	0.488		NA											44	77					0	0	0	0
URGCP	55665	broad.mit.edu	37	7	43917780	43917780	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:43917780C>A	uc003tiw.2	-	6	1339	c.1282G>T	c.(1282-1284)GTG>TTG	p.V428L	URGCP_uc003tiu.2_Missense_Mutation_p.V385L|URGCP_uc003tiv.2_Missense_Mutation_p.V353L|URGCP_uc003tix.2_Missense_Mutation_p.V419L|URGCP_uc003tiy.2_Missense_Mutation_p.V385L|URGCP_uc003tiz.2_Missense_Mutation_p.V385L|URGCP_uc011kbj.1_Missense_Mutation_p.V385L	NM_001077663	NP_001071131	Q8TCY9	URGCP_HUMAN	up-regulated gene 4 isoform 3	428					cell cycle	centrosome|nucleus	GTP binding			ovary(2)|liver(1)|skin(1)	4						ATCCTCTTCACGAAGCTGTCG	0.537		NA											46	110					1.49e-19	2.14e-19	1	0
DDX56	54606	broad.mit.edu	37	7	44609415	44609415	+	Silent	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:44609415G>A	uc003tlg.2	-	9	1855	c.1212C>T	c.(1210-1212)CTC>CTT	p.L404L	DDX56_uc003tle.2_RNA|DDX56_uc003tlf.2_Silent_p.L340L|DDX56_uc003tlh.2_RNA|DDX56_uc010kyg.2_Silent_p.L364L|DDX56_uc010kyh.1_RNA	NM_019082	NP_061955	Q9NY93	DDX56_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 56	404	Helicase C-terminal.				rRNA processing	nucleolus	ATP binding|ATP-dependent RNA helicase activity|identical protein binding|RNA binding			upper_aerodigestive_tract(1)	1						TACCTCCACTGAGAAGCTCCT	0.507		NA											12	12					0	0	0	0
ZNF479	90827	broad.mit.edu	37	7	57194381	57194381	+	Silent	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:57194381C>T	uc010kzo.2	-	3	355	c.84G>A	c.(82-84)GAG>GAA	p.E28E		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	zinc finger protein 479	28	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(1;9.18e-12)			ATTGCCATTCCTCCAGAGAGA	0.438		NA											30	46					0	0	0	0
ZNF735	730291	broad.mit.edu	37	7	63680233	63680233	+	Silent	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:63680233C>A	uc011kdn.1	+	4	804	c.804C>A	c.(802-804)CCC>CCA	p.P268P		NM_001159524	NP_001152996	P0CB33	ZN735_HUMAN	zinc finger protein 735	268					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GAGAGAAACCCTACGCATGTG	0.448		NA											8	22					0.000157383	0.000174701	1	0
NSUN5	55695	broad.mit.edu	37	7	72718297	72718297	+	Silent	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:72718297C>A	uc003txw.2	-	7	900	c.864G>T	c.(862-864)GCG>GCT	p.A288A	FKBP6_uc003twz.2_Intron|NSUN5_uc003txv.2_Silent_p.A288A|NSUN5_uc003txx.2_Silent_p.A250A|NSUN5_uc011kev.1_Silent_p.A288A	NM_018044	NP_060514	Q96P11	NSUN5_HUMAN	NOL1/NOP2/Sun domain family, member 5 isoform 2	288							methyltransferase activity				0		Lung NSC(55;0.163)				AGGGGGAGACCGCCAGGAAGT	0.592		NA											17	33					5.39e-06	6.24e-06	1	0
PCLO	27445	broad.mit.edu	37	7	82584629	82584629	+	Silent	SNP	T	T	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:82584629T>A	uc003uhx.2	-	5	5929	c.5640A>T	c.(5638-5640)GTA>GTT	p.V1880V	PCLO_uc003uhv.2_Silent_p.V1880V	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1811					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						AAACTTTTTGTACTTCTATTA	0.368		NA											22	34					0	0	0	0
ABCB1	5243	broad.mit.edu	37	7	87173503	87173503	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:87173503G>T	uc003uiz.1	-	18	2571	c.2153C>A	c.(2152-2154)GCC>GAC	p.A718D	ABCB1_uc011khc.1_Missense_Mutation_p.A654D	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	718	ABC transmembrane type-1 2.|Helical; (Potential).				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	ATTTATAATGGCACAAAATAC	0.358		NA											33	55					1.4e-27	2.11e-27	1	0
STEAP4	79689	broad.mit.edu	37	7	87910388	87910388	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:87910388G>A	uc003ujs.2	-	4	1096	c.991C>T	c.(991-993)CTC>TTC	p.L331F	STEAP4_uc010lek.2_Missense_Mutation_p.L155F	NM_024636	NP_078912	Q687X5	STEA4_HUMAN	tumor necrosis factor, alpha-induced protein 9	331	Ferric oxidoreductase.				fat cell differentiation|ion transport|iron ion homeostasis	Golgi membrane|integral to membrane|plasma membrane	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity				0	Esophageal squamous(14;0.00802)					TCCTTCTTGAGTATTGCCTAA	0.368		NA											13	23					0	0	0	0
STEAP2	261729	broad.mit.edu	37	7	89856546	89856546	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:89856546A>G	uc003ujz.2	+	3	1147	c.754A>G	c.(754-756)ATA>GTA	p.I252V	STEAP2_uc003ujy.2_Missense_Mutation_p.I294V|STEAP2_uc010len.2_Missense_Mutation_p.I252V|STEAP2_uc003uka.2_Missense_Mutation_p.I252V|STEAP2_uc003ukb.2_Missense_Mutation_p.I252V|STEAP2_uc003ukc.2_Missense_Mutation_p.I252V|STEAP2_uc003ukd.2_Missense_Mutation_p.I252V	NM_152999	NP_694544	Q8NFT2	STEA2_HUMAN	six transmembrane epithelial antigen of the	252					electron transport chain|endocytosis|Golgi to plasma membrane transport|ion transport|iron ion homeostasis|regulated secretory pathway|response to hormone stimulus	cytosol|early endosome|endosome membrane|integral to Golgi membrane|plasma membrane|trans-Golgi network transport vesicle|vesicular fraction	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity|transporter activity			ovary(2)	2	all_hematologic(106;0.112)					CAAAATTCCTATAGAGATTGT	0.378		NA											36	62					0	0	0	0
PEX1	5189	broad.mit.edu	37	7	92143172	92143172	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:92143172C>G	uc003uly.2	-	6	1445	c.1349G>C	c.(1348-1350)AGA>ACA	p.R450T	PEX1_uc011khr.1_Missense_Mutation_p.R242T|PEX1_uc010ley.2_Missense_Mutation_p.R450T|PEX1_uc011khs.1_Missense_Mutation_p.R128T|PEX1_uc011kht.1_RNA	NM_000466	NP_000457	O43933	PEX1_HUMAN	peroxin1	450					microtubule-based peroxisome localization|protein import into peroxisome matrix	cytosol|nucleus|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			ovary(1)|central_nervous_system(1)	2	all_cancers(62;9.35e-11)|all_epithelial(64;4.59e-10)|Breast(17;0.00201)|all_lung(186;0.0438)|Lung NSC(181;0.0592)	Breast(660;0.000932)|all_neural(109;0.00391)|Myeloproliferative disorder(862;0.0122)|Ovarian(593;0.023)|Medulloblastoma(109;0.123)	GBM - Glioblastoma multiforme(5;4.06e-06)|STAD - Stomach adenocarcinoma(4;4.51e-05)|all cancers(6;5.32e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			TAAATTCTCTCTAGGTTGTAA	0.328		NA											41	70					0	0	0	0
HEPACAM2	253012	broad.mit.edu	37	7	92848626	92848626	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:92848626G>A	uc003umm.2	-	2	241	c.218C>T	c.(217-219)CCC>CTC	p.P73L	HEPACAM2_uc003uml.2_Missense_Mutation_p.P61L|HEPACAM2_uc010lff.2_Missense_Mutation_p.P61L|HEPACAM2_uc011khy.1_Missense_Mutation_p.P96L	NM_001039372	NP_001034461	A8MVW5	HECA2_HUMAN	HEPACAM family member 2 isoform 1	73	Extracellular (Potential).					integral to membrane				ovary(3)|breast(1)|kidney(1)	5						CATTGTGTGGGGTCTCTCAAA	0.498		NA											38	55					0	0	0	0
FBXO24	26261	broad.mit.edu	37	7	100192139	100192139	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:100192139C>A	uc003uvm.1	+	6	1220	c.927C>A	c.(925-927)AAC>AAA	p.N309K	FBXO24_uc003uvl.1_Missense_Mutation_p.N295K|FBXO24_uc003uvn.1_Missense_Mutation_p.N4K|uc011kjy.1_Intron|FBXO24_uc011kjz.1_Missense_Mutation_p.N347K|FBXO24_uc011kka.1_Missense_Mutation_p.N297K	NM_033506	NP_277041	O75426	FBX24_HUMAN	F-box only protein 24 isoform 1	309						ubiquitin ligase complex	ubiquitin-protein ligase activity			ovary(3)|skin(1)	4	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					TGACTTCCAACCAGAGCAGCA	0.602		NA											18	22					5.01e-05	5.62e-05	1	0
ACHE	43	broad.mit.edu	37	7	100490790	100490790	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:100490790A>G	uc003uxd.2	-	1	1220	c.1064T>C	c.(1063-1065)CTG>CCG	p.L355P	ACHE_uc003uxe.2_Missense_Mutation_p.L355P|ACHE_uc003uxf.2_Missense_Mutation_p.L355P|ACHE_uc003uxg.2_Missense_Mutation_p.L355P|ACHE_uc003uxh.2_Missense_Mutation_p.L355P|ACHE_uc003uxi.2_Missense_Mutation_p.L355P|ACHE_uc003uxj.1_Missense_Mutation_p.L474P	NM_000665	NP_000656	P22303	ACES_HUMAN	acetylcholinesterase isoform E4-E6 precursor	355					acetylcholine catabolic process in synaptic cleft|amyloid precursor protein metabolic process|cell adhesion|cell proliferation|choline metabolic process|DNA replication|muscle organ development|neurotransmitter biosynthetic process|osteoblast development|positive regulation of protein secretion|regulation of axonogenesis|regulation of dendrite morphogenesis|response to wounding|synapse assembly	anchored to membrane|axon|basal lamina|cell junction|cell surface|dendrite|endoplasmic reticulum lumen|extracellular space|Golgi apparatus|neuromuscular junction|nucleus|perinuclear region of cytoplasm|postsynaptic membrane|presynaptic membrane|synaptic cleft	acetylcholine binding|acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|collagen binding|laminin-1 binding|protein homodimerization activity|serine hydrolase activity			skin(2)	2	Lung NSC(181;0.041)|all_lung(186;0.0581)				Ambenonium(DB01122)|Atropine(DB00572)|Choline(DB00122)|Decamethonium(DB01245)|Demecarium bromide(DB00944)|Donepezil(DB00843)|Edrophonium(DB01010)|Ephedrine(DB01364)|Galantamine(DB00674)|Gallamine Triethiodide(DB00483)|Isoflurophate(DB00677)|Neostigmine(DB01400)|Physostigmine(DB00981)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Tacrine(DB00382)|Tubocurarine(DB01199)	AGTTACCTGCAGGCCGTGGAA	0.622		NA											7	19					0	0	0	0
MUC17	140453	broad.mit.edu	37	7	100679156	100679156	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:100679156G>A	uc003uxp.1	+	3	4512	c.4459G>A	c.(4459-4461)GTC>ATC	p.V1487I	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1487	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|23.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CAGTCCTGTGGTCACTTCTAC	0.468		NA											100	238					0	0	0	0
RELN	5649	broad.mit.edu	37	7	103389906	103389906	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:103389906G>T	uc003vca.2	-	6	783	c.623C>A	c.(622-624)TCC>TAC	p.S208Y	RELN_uc010liz.2_Missense_Mutation_p.S208Y	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	208					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TTGGTGGTAGGAGTCAAAGTC	0.343		NA											57	70					2.17e-29	3.28e-29	1	0
LAMB4	22798	broad.mit.edu	37	7	107704266	107704266	+	Missense_Mutation	SNP	C	C	T	rs142967094		TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:107704266C>T	uc010ljo.1	-	22	3085	c.3001G>A	c.(3001-3003)GCA>ACA	p.A1001T	LAMB4_uc003vey.2_Missense_Mutation_p.A1001T|LAMB4_uc010ljp.1_5'UTR	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	1001	Laminin EGF-like 10.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8						TGGCAGTTTGCGCCCTGAGTG	0.527		NA											51	107					0	0	0	0
IFRD1	3475	broad.mit.edu	37	7	112097034	112097034	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:112097034A>G	uc003vgh.2	+	5	793	c.350A>G	c.(349-351)GAA>GGA	p.E117G	IFRD1_uc011kmn.1_Missense_Mutation_p.E67G|IFRD1_uc003vgi.2_Missense_Mutation_p.E117G|IFRD1_uc003vgj.2_Missense_Mutation_p.E117G|IFRD1_uc011kmo.1_RNA|IFRD1_uc011kmp.1_Missense_Mutation_p.E67G	NM_001007245	NP_001007246	O00458	IFRD1_HUMAN	interferon-related developmental regulator 1	117					multicellular organismal development|myoblast cell fate determination		binding			kidney(1)|central_nervous_system(1)	2						ATGCTGTATGAATTTATTCTG	0.368		NA											26	40					0	0	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113518193	113518193	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:113518193G>T	uc010ljy.1	-	4	2985	c.2954C>A	c.(2953-2955)TCA>TAA	p.S985*		NM_002711	NP_002702	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	985					glycogen metabolic process	integral to membrane				lung(9)|ovary(9)|pancreas(7)|skin(6)|breast(2)|prostate(1)	34						TCTACTACCTGATGTCACTAT	0.368		NA											12	90					1.09e-07	1.31e-07	1	0
RNF133	168433	broad.mit.edu	37	7	122338457	122338457	+	Silent	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:122338457G>A	uc003vkj.1	-	1	752	c.516C>T	c.(514-516)CTC>CTT	p.L172L	CADPS2_uc010lkp.2_Intron|CADPS2_uc010lkq.2_Intron	NM_139175	NP_631914	Q8WVZ7	RN133_HUMAN	ring finger protein 133	172						endoplasmic reticulum membrane|integral to membrane	ligase activity|zinc ion binding			skin(1)	1						CGGCTGTAATGAGAACTCCCT	0.398		NA											51	96					0	0	0	0
RNF133	168433	broad.mit.edu	37	7	122338764	122338764	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:122338764C>A	uc003vkj.1	-	1	445	c.209G>T	c.(208-210)AGA>ATA	p.R70I	CADPS2_uc010lkp.2_Intron|CADPS2_uc010lkq.2_Intron	NM_139175	NP_631914	Q8WVZ7	RN133_HUMAN	ring finger protein 133	70	PA.					endoplasmic reticulum membrane|integral to membrane	ligase activity|zinc ion binding			skin(1)	1						TCCTGCCACTCTCTTCAAAGT	0.433		NA											63	78					2.45e-20	3.54e-20	1	0
NDUFA5	4698	broad.mit.edu	37	7	123197486	123197486	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:123197486C>G	uc003vks.2	-	2	147	c.38G>C	c.(37-39)GGA>GCA	p.G13A	NDUFA5_uc003vkr.2_RNA|NDUFA5_uc003vkt.1_Missense_Mutation_p.G13A	NM_005000	NP_004991	Q16718	NDUA5_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	13					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity				0					NADH(DB00157)	CACAGCCAATCCCACAAGGCC	0.423		NA											5	54					0	0	0	0
GCC1	79571	broad.mit.edu	37	7	127224972	127224972	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:127224972T>A	uc003vma.2	-	1	683	c.265A>T	c.(265-267)ACT>TCT	p.T89S		NM_024523	NP_078799	Q96CN9	GCC1_HUMAN	Golgi coiled-coil protein 1	89						Golgi membrane|plasma membrane	protein binding			ovary(2)	2						TCGCTGTGAGTGGAGCACCGG	0.597		NA											26	44					0	0	0	0
RAB19	401409	broad.mit.edu	37	7	140125809	140125809	+	Silent	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:140125809C>T	uc010lni.2	+	4	711	c.513C>T	c.(511-513)GTC>GTT	p.V171V	RAB19_uc011krc.1_Silent_p.V171V	NM_001008749	NP_001008749	A4D1S5	RAB19_HUMAN	RAB19, member RAS oncogene family	171					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding				0	Melanoma(164;0.0142)					TAGAAGAAGTCTTCGTGCTCA	0.582		NA											31	92					0	0	0	0
TAS2R4	50832	broad.mit.edu	37	7	141478516	141478516	+	Silent	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:141478516G>A	uc003vwq.1	+	1	228	c.228G>A	c.(226-228)AGG>AGA	p.R76R		NM_016944	NP_058640	Q9NYW5	TA2R4_HUMAN	taste receptor T2R4	76	Extracellular (Potential).				sensory perception of taste	cilium membrane	taste receptor activity				0	Melanoma(164;0.0171)			BRCA - Breast invasive adenocarcinoma(188;0.196)		ATACGGAAAGGTCAGTCTACC	0.433		NA											65	116					0	0	0	0
PRSS1	5644	broad.mit.edu	37	7	142459743	142459743	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:142459743G>A	uc003wak.2	+	3	336	c.319G>A	c.(319-321)GAC>AAC	p.D107N	uc011krr.1_Intron|uc003vzp.2_Intron|uc011ksh.1_Intron|uc011ksi.1_Intron|uc003vzw.1_Intron|uc010loj.1_Intron|uc003wad.2_Intron|uc003wag.1_Intron|TRY6_uc011ksn.1_Intron|PRSS1_uc011ksm.1_3'UTR|PRSS1_uc003wam.2_Missense_Mutation_p.D47N	NM_002769	NP_002760	P07477	TRY1_HUMAN	protease, serine, 1 preproprotein	107	Peptidase S1.	Charge relay system.			digestion|proteolysis	extracellular space	metal ion binding|protein binding|serine-type endopeptidase activity			large_intestine(1)|central_nervous_system(1)	2	Melanoma(164;0.047)	all_cancers(3;2.14e-49)|Acute lymphoblastic leukemia(3;7.3e-185)|all_hematologic(3;1.1e-165)	all cancers(2;0.000126)|Colorectal(2;0.000157)|Epithelial(2;0.000191)|COAD - Colon adenocarcinoma(2;0.00189)			TCTGAACAATGACATCATGTT	0.552		NA							Hereditary_Pancreatitis				11	165					0	0	0	0
OR2F1	26211	broad.mit.edu	37	7	143657597	143657597	+	Silent	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:143657597C>T	uc003wds.1	+	1	578	c.534C>T	c.(532-534)TCC>TCT	p.S178S		NM_012369	NP_036501	Q13607	OR2F1_HUMAN	olfactory receptor, family 2, subfamily F,	178	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	Melanoma(164;0.0903)					ATCACATATCCTGTGAACTCC	0.498		NA											36	56					0	0	0	0
ZNF425	155054	broad.mit.edu	37	7	148800930	148800930	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:148800930C>T	uc003wfj.2	-	4	2106	c.2033G>A	c.(2032-2034)AGG>AAG	p.R678K		NM_001001661	NP_001001661	Q6IV72	ZN425_HUMAN	zinc finger protein 425	678	C2H2-type 17.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)	3	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			CAAGCTGCCCCTGATGCAGTA	0.547		NA											56	95					0	0	0	0
GIMAP8	155038	broad.mit.edu	37	7	150164299	150164299	+	Silent	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:150164299G>A	uc003whj.2	+	2	843	c.513G>A	c.(511-513)AAG>AAA	p.K171K		NM_175571	NP_783161	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	171						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		TCAACAACAAGACCAATAGTA	0.443		NA											8	142					0	0	0	0
AGAP3	116988	broad.mit.edu	37	7	150784095	150784095	+	Silent	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:150784095G>T	uc003wjg.1	+	1	270	c.267G>T	c.(265-267)CTG>CTT	p.L89L	AGAP3_uc003wje.1_Intron|AGAP3_uc003wjf.1_Silent_p.L89L|AGAP3_uc010lpy.1_Silent_p.L89L	NM_031946	NP_114152	Q96P47	AGAP3_HUMAN	centaurin, gamma 3 isoform a	53					regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm|membrane	ARF GTPase activator activity|GTP binding|GTPase activity|zinc ion binding			central_nervous_system(2)|ovary(1)	3						TCTACGACCTGATCGAGCGCA	0.667		NA											7	12					1.77e-08	2.18e-08	1	0
MLL3	58508	broad.mit.edu	37	7	151877135	151877135	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr7:151877135T>C	uc003wla.2	-	37	7445	c.7226A>G	c.(7225-7227)CAG>CGG	p.Q2409R	MLL3_uc003wkz.2_Missense_Mutation_p.Q1470R|MLL3_uc003wky.2_5'Flank	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	2409					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		GGGTGAGTCCTGTGACCCCTT	0.517		NA	N		medulloblastoma								99	190					0	0	0	0
DLGAP2	9228	broad.mit.edu	37	8	1497720	1497720	+	Silent	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr8:1497720G>A	uc003wpl.2	+	2	958	c.861G>A	c.(859-861)AAG>AAA	p.K287K	DLGAP2_uc003wpm.2_Silent_p.K287K	NM_004745	NP_004736	Q9P1A6	DLGP2_HUMAN	discs large-associated protein 2	366					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding				0		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		AGTACCTGAAGCGCAGCTCCT	0.642		NA											11	40					0	0	0	0
CSMD1	64478	broad.mit.edu	37	8	3226842	3226842	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr8:3226842C>A	uc011kwk.1	-	19	3226	c.2836G>T	c.(2836-2838)GGG>TGG	p.G946W	CSMD1_uc011kwj.1_Missense_Mutation_p.G338W|CSMD1_uc003wqe.2_Missense_Mutation_p.G102W	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	946	Extracellular (Potential).|CUB 6.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TCTGGAAACCCAGGAGAAAGG	0.393		NA											17	14					6.94e-10	8.8e-10	1	0
XKR6	286046	broad.mit.edu	37	8	10782284	10782284	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr8:10782284C>T	uc003wtk.1	-	2	848	c.821G>A	c.(820-822)CGA>CAA	p.R274Q		NM_173683	NP_775954	Q5GH73	XKR6_HUMAN	XK, Kell blood group complex subunit-related	274						integral to membrane				ovary(1)|skin(1)	2				Lung(29;0.0407)|COAD - Colon adenocarcinoma(149;0.0555)		GTAGAAGCGTCGCTGGTGTTC	0.582		NA											7	117					0	0	0	0
SGCZ	137868	broad.mit.edu	37	8	13959908	13959909	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr8:13959908_13959909GG>TT	uc003wwq.2	-	7	1380_1381	c.720_721CC>AA	c.(718-723)CTCCAT>CTAAAT	p.H241N	SGCZ_uc010lss.2_Missense_Mutation_p.H194N	NM_139167	NP_631906	Q96LD1	SGCZ_HUMAN	sarcoglycan zeta	228	Extracellular (Potential).				cytoskeleton organization	cytoplasm|cytoskeleton|integral to membrane|sarcolemma				ovary(2)|central_nervous_system(1)	3				all cancers(2;0.000643)|Colorectal(111;0.00674)|COAD - Colon adenocarcinoma(73;0.0193)|GBM - Glioblastoma multiforme(2;0.026)		GATTGCAGATGGAGCTCCTTCC	0.515		NA											24	63					0	0	0	0
ENTPD4	9583	broad.mit.edu	37	8	23243466	23243466	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr8:23243466T>G	uc011kzu.1	-	13	1963	c.1691A>C	c.(1690-1692)CAC>CCC	p.H564P	LOXL2_uc003xdh.1_Intron	NM_001128930	NP_001122402	Q9Y227	ENTP4_HUMAN	ectonucleoside triphosphate diphosphohydrolase 4	Error:Variant_position_missing_in_Q9Y227_after_alignment					UDP catabolic process	autophagic vacuole membrane|cytoplasmic vesicle|integral to Golgi membrane	uridine-diphosphatase activity			ovary(1)|kidney(1)	2		Prostate(55;0.114)		Colorectal(74;0.0161)|COAD - Colon adenocarcinoma(73;0.0649)		acattgcaagtgtttggtggc	0.015		NA											35	92					0	0	0	0
ADRA1A	148	broad.mit.edu	37	8	26721992	26721992	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr8:26721992C>G	uc003xfh.1	-	1	931	c.495G>C	c.(493-495)TGG>TGC	p.W165C	ADRA1A_uc003xfc.1_Missense_Mutation_p.W165C|ADRA1A_uc010lul.1_Missense_Mutation_p.W165C|ADRA1A_uc003xfd.1_RNA|ADRA1A_uc003xfe.1_Missense_Mutation_p.W165C|ADRA1A_uc010lum.1_Missense_Mutation_p.W165C|ADRA1A_uc003xff.1_RNA|ADRA1A_uc003xfg.1_Missense_Mutation_p.W165C	NM_000680	NP_000671	P35348	ADA1A_HUMAN	alpha-1A-adrenergic receptor isoform 1	165	Helical; Name=4; (By similarity).				activation of phospholipase C activity|aging|apoptosis|calcium ion transport into cytosol|cell-cell signaling|intracellular protein kinase cascade|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of synaptic transmission, GABAergic|positive regulation of action potential|positive regulation of cardiac muscle contraction|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase C signaling cascade|positive regulation of vasoconstriction|response to drug|response to hormone stimulus|response to stress|smooth muscle contraction	integral to plasma membrane	alpha1-adrenergic receptor activity			breast(2)|ovary(1)|lung(1)|skin(1)	5		all_cancers(63;0.122)|Ovarian(32;2.61e-05)|all_epithelial(46;0.118)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|Epithelial(17;4.92e-10)|Colorectal(74;0.0132)|READ - Rectum adenocarcinoma(644;0.115)	Alfuzosin(DB00346)|Amiodarone(DB01118)|Amphetamine(DB00182)|Benzphetamine(DB00865)|Bethanidine(DB00217)|Carvedilol(DB01136)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Dextroamphetamine(DB01576)|Doxazosin(DB00590)|Epinastine(DB00751)|Epinephrine(DB00668)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Labetalol(DB00598)|Lisdexamfetamine(DB01255)|Maprotiline(DB00934)|Mephentermine(DB01365)|Metaraminol(DB00610)|Methamphetamine(DB01577)|Methotrimeprazine(DB01403)|Methoxamine(DB00723)|Midodrine(DB00211)|Nefazodone(DB01149)|Nicergoline(DB00699)|Nilutamide(DB00665)|Norepinephrine(DB00368)|Norgestrel(DB00506)|Oxymetazoline(DB00935)|Perphenazine(DB00850)|Phendimetrazine(DB01579)|Phenoxybenzamine(DB00925)|Phenylephrine(DB00388)|Phenylpropanolamine(DB00397)|Prazosin(DB00457)|Promazine(DB00420)|Promethazine(DB01069)|Propericiazine(DB01608)|Propiomazine(DB00777)|Pseudoephedrine(DB00852)|Risperidone(DB00734)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)|Thioridazine(DB00679)|Tolazoline(DB00797)|Trazodone(DB00656)|Trifluoperazine(DB00831)|Ziprasidone(DB00246)	CCGGCTGCCTCCAGCCGAACA	0.637		NA											30	32					0	0	0	0
KIF13B	23303	broad.mit.edu	37	8	29037627	29037627	+	Silent	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr8:29037627C>T	uc003xhh.3	-	8	773	c.714G>A	c.(712-714)AAG>AAA	p.K238K	KIF13B_uc003xhj.2_Silent_p.K135K|KIF13B_uc010lvf.1_Silent_p.K174K	NM_015254	NP_056069	Q9NQT8	KI13B_HUMAN	kinesin family member 13B	238	Kinesin-motor.				microtubule-based movement|protein targeting|signal transduction|T cell activation	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein kinase binding				0		Ovarian(32;0.000536)		KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)		CTACCCCAGACTTCACATCGT	0.408		NA											52	135					0	0	0	0
ST18	9705	broad.mit.edu	37	8	53025853	53025853	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr8:53025853T>G	uc003xqz.2	-	21	3205	c.3049A>C	c.(3049-3051)ACA>CCA	p.T1017P	ST18_uc011ldq.1_Missense_Mutation_p.T664P|ST18_uc011ldr.1_Missense_Mutation_p.T982P|ST18_uc011lds.1_Missense_Mutation_p.T922P|ST18_uc003xra.2_Missense_Mutation_p.T1017P	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	1017						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				TACATATCTGTGAGTGTATTT	0.433		NA											31	88					0	0	0	0
RP1	6101	broad.mit.edu	37	8	55540739	55540739	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr8:55540739G>T	uc003xsd.1	+	4	4445	c.4297G>T	c.(4297-4299)GCA>TCA	p.A1433S	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	1433					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			GGATGAAAATGCATATACTTC	0.363		NA											26	72					1.43e-11	1.86e-11	1	0
LYN	4067	broad.mit.edu	37	8	56879420	56879420	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr8:56879420G>T	uc003xsk.3	+	9	1219	c.937G>T	c.(937-939)GAG>TAG	p.E313*	LYN_uc003xsl.3_Nonsense_Mutation_p.E292*	NM_002350	NP_002341	P07948	LYN_HUMAN	Yamaguchi sarcoma viral (v-yes-1) oncogene	313	Protein kinase.				erythrocyte differentiation|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of cellular component movement|positive regulation of stress-activated protein kinase signaling cascade|positive regulation of tyrosine phosphorylation of STAT protein|response to DNA damage stimulus|T cell costimulation	cytosol|Golgi apparatus|membrane raft|nucleus|perinuclear region of cytoplasm	ATP binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity|receptor signaling protein tyrosine kinase activity			ovary(1)|breast(1)|central_nervous_system(1)	3		all_lung(136;0.0555)|Lung NSC(129;0.0726)|all_epithelial(80;0.0772)	Epithelial(17;0.000834)|all cancers(17;0.00598)			CACCAGGGAGGAGCCCATTTA	0.512		NA											15	57					1.57e-10	2.02e-10	1	0
NSMAF	8439	broad.mit.edu	37	8	59514633	59514633	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr8:59514633C>A	uc003xtt.2	-	14	1323	c.1109G>T	c.(1108-1110)CGG>CTG	p.R370L	NSMAF_uc011lee.1_Missense_Mutation_p.R401L|NSMAF_uc003xtu.2_Missense_Mutation_p.R370L	NM_003580	NP_003571	Q92636	FAN_HUMAN	neutral sphingomyelinase (N-SMase) activation	370	BEACH.				ceramide metabolic process	cytoplasm|soluble fraction	protein binding|receptor signaling protein activity			ovary(1)	1		all_lung(136;0.174)|Lung NSC(129;0.2)				TCTCTCCAGCCGTTCCTTATT	0.413		NA											39	112					1.75e-18	2.47e-18	1	0
NSMAF	8439	broad.mit.edu	37	8	59548030	59548030	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr8:59548030G>C	uc003xtt.2	-	3	439	c.225C>G	c.(223-225)ATC>ATG	p.I75M	NSMAF_uc011lee.1_Missense_Mutation_p.I106M|NSMAF_uc003xtu.2_Missense_Mutation_p.I75M	NM_003580	NP_003571	Q92636	FAN_HUMAN	neutral sphingomyelinase (N-SMase) activation	75					ceramide metabolic process	cytoplasm|soluble fraction	protein binding|receptor signaling protein activity			ovary(1)	1		all_lung(136;0.174)|Lung NSC(129;0.2)				TATTTACCTTGATGATGGGCT	0.308		NA											12	227					0	0	0	0
ASPH	444	broad.mit.edu	37	8	62415961	62415961	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr8:62415961G>A	uc003xuj.2	-	25	2503	c.2234C>T	c.(2233-2235)CCG>CTG	p.P745L	ASPH_uc011leg.1_Missense_Mutation_p.P716L	NM_004318	NP_004309	Q12797	ASPH_HUMAN	aspartate beta-hydroxylase isoform a	745	Lumenal (Potential).				muscle contraction	integral to endoplasmic reticulum membrane	calcium ion binding|electron carrier activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity|structural constituent of muscle			ovary(3)	3	Lung SC(2;0.153)	Lung NSC(129;0.0358)|all_lung(136;0.0654)|all_epithelial(80;0.101)			L-Aspartic Acid(DB00128)|Succinic acid(DB00139)	TGTCAGTTCCGGATGCCACAC	0.512		NA											4	51					0	0	0	0
BHLHE22	27319	broad.mit.edu	37	8	65493499	65493499	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr8:65493499G>A	uc003xvi.2	+	1	686	c.152G>A	c.(151-153)CGG>CAG	p.R51Q	LOC401463_uc003xvh.2_Intron	NM_152414	NP_689627	Q8NFJ8	BHE22_HUMAN	basic helix-loop-helix domain containing, class	51					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0						CCGCCGCCTCGGGAACGCCCG	0.706		NA											8	5					0	0	0	0
ATP6V0D2	245972	broad.mit.edu	37	8	87126074	87126074	+	Silent	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr8:87126074C>A	uc003ydp.1	+	2	336	c.267C>A	c.(265-267)TCC>TCA	p.S89S		NM_152565	NP_689778	Q8N8Y2	VA0D2_HUMAN	ATPase, H+ transporting, lysosomal 38kDa, V0	89					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	apical plasma membrane|endosome membrane|proton-transporting V-type ATPase, V0 domain|vacuolar proton-transporting V-type ATPase complex	hydrogen ion transmembrane transporter activity|protein binding				0						GGAATCATTCCCTGGAGCCCC	0.423		NA											25	121					4.6e-10	5.84e-10	1	0
MMP16	4325	broad.mit.edu	37	8	89128829	89128829	+	Silent	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr8:89128829G>A	uc003yeb.3	-	6	1272	c.990C>T	c.(988-990)ACC>ACT	p.T330T	MMP16_uc003yec.2_Silent_p.T330T	NM_005941	NP_005932	P51512	MMP16_HUMAN	matrix metalloproteinase 16 isoform 1	330	Extracellular (Potential).				collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)|urinary_tract(1)|skin(1)|kidney(1)	8						AGGGTCTGCCGGTTGGAGGCC	0.532		NA											78	56					0	0	0	0
RIPK2	8767	broad.mit.edu	37	8	90777691	90777691	+	Silent	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr8:90777691G>A	uc003yee.2	+	3	764	c.450G>A	c.(448-450)CAG>CAA	p.Q150Q	RIPK2_uc003yef.2_Silent_p.Q13Q	NM_003821	NP_003812	O43353	RIPK2_HUMAN	receptor-interacting serine-threonine kinase 2	150	Protein kinase.				activation of MAPK activity|anti-apoptosis|apoptosis|inflammatory response|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein ubiquitination|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|CARD domain binding|LIM domain binding|protein homodimerization activity|protein serine/threonine kinase activity|signal transducer activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(11;0.0474)			TGAAGACTCAGAATATCTTAT	0.313		NA											7	90					0	0	0	0
CALB1	793	broad.mit.edu	37	8	91081386	91081386	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr8:91081386A>T	uc003yel.1	-	4	493	c.311T>A	c.(310-312)ATG>AAG	p.M104K	CALB1_uc011lge.1_Missense_Mutation_p.M47K	NM_004929	NP_004920	P05937	CALB1_HUMAN	calbindin 1	104	EF-hand 3.					nucleus	calcium ion binding|vitamin D binding			pancreas(1)	1			BRCA - Breast invasive adenocarcinoma(11;0.00953)			TTATACCTTCATGAATTCCTC	0.378		NA											8	57					0	0	0	0
RUNX1T1	862	broad.mit.edu	37	8	93003956	93003956	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr8:93003956C>T	uc003yfd.2	-	6	986	c.902G>A	c.(901-903)CGT>CAT	p.R301H	RUNX1T1_uc003yfc.1_Missense_Mutation_p.R274H|RUNX1T1_uc003yfe.1_Missense_Mutation_p.R264H|RUNX1T1_uc010mao.2_Missense_Mutation_p.R274H|RUNX1T1_uc011lgi.1_Missense_Mutation_p.R312H|RUNX1T1_uc010man.1_5'UTR|RUNX1T1_uc003yfb.1_Missense_Mutation_p.R264H	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	301					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			ATCATCCAAACGGTAATGCTG	0.552		NA											20	124					0	0	0	0
RUNX1T1	862	broad.mit.edu	37	8	93027017	93027017	+	Silent	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr8:93027017G>A	uc003yfd.2	-	3	342	c.258C>T	c.(256-258)GCC>GCT	p.A86A	RUNX1T1_uc003yfc.1_Silent_p.A59A|RUNX1T1_uc003yfe.1_Silent_p.A49A|RUNX1T1_uc010mao.2_Silent_p.A59A|RUNX1T1_uc011lgi.1_Silent_p.A97A|RUNX1T1_uc003yfh.1_Silent_p.A49A|RUNX1T1_uc003yfb.1_Silent_p.A49A|RUNX1T1_uc003yff.1_Silent_p.A49A|RUNX1T1_uc003yfg.1_Silent_p.A49A	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	86					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			CGCCATTCAAGGCTGTAGGAG	0.512		NA											8	51					0	0	0	0
FAM135B	51059	broad.mit.edu	37	8	139149455	139149455	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr8:139149455C>G	uc003yuy.2	-	19	4121	c.3950G>C	c.(3949-3951)CGT>CCT	p.R1317P	FAM135B_uc003yux.2_Missense_Mutation_p.R1218P|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	1317										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TGGCACATAACGGTCTTGGGG	0.413		NA								HNSCC(54;0.14)			24	117					0	0	0	0
COL22A1	169044	broad.mit.edu	37	8	139603718	139603718	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr8:139603718C>T	uc003yvd.2	-	64	5089	c.4642G>A	c.(4642-4644)GGT>AGT	p.G1548S	COL22A1_uc011ljo.1_Missense_Mutation_p.G828S	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1548	Pro-rich.|Gly-rich.|Collagen-like 15.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			CCAGGTGCACCTGGGTCACCT	0.602		NA								HNSCC(7;0.00092)			3	19					0	0	0	0
FLJ43860	389690	broad.mit.edu	37	8	142486153	142486153	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr8:142486153C>G	uc003ywi.2	-	13	1621	c.1540G>C	c.(1540-1542)GAG>CAG	p.E514Q	FLJ43860_uc011ljs.1_Intron|FLJ43860_uc010meu.1_Intron	NM_207414	NP_997297	Q6ZUA9	Q6ZUA9_HUMAN	hypothetical protein LOC389690	514							binding				0	all_cancers(97;7.79e-15)|all_epithelial(106;4.52e-13)|Lung NSC(106;2.07e-05)|all_lung(105;2.89e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			GTGTGCTTCTCCAGGGCATCC	0.642		NA											6	19					0	0	0	0
RPL8	6132	broad.mit.edu	37	8	146017246	146017246	+	Silent	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr8:146017246C>A	uc003zeb.2	-	3	303	c.192G>T	c.(190-192)CGG>CGT	p.R64R	RPL8_uc003zdz.2_RNA|RPL8_uc003zea.2_Intron|RPL8_uc003zec.2_Silent_p.R64R|RPL8_uc010mgc.2_Silent_p.R64R	NM_033301	NP_150644	P62917	RL8_HUMAN	ribosomal protein L8	64					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	rRNA binding|structural constituent of ribosome				0	all_cancers(97;1.03e-11)|all_epithelial(106;6.69e-11)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Epithelial(56;5.47e-39)|OV - Ovarian serous cystadenocarcinoma(54;6.38e-39)|all cancers(56;5.47e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.191)		GATACGGATCCCGGAAGACCA	0.657		NA											33	171					3.28e-08	4.02e-08	1	0
CDKN2A	1029	broad.mit.edu	37	9	21971035	21971035	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr9:21971035T>A	uc003zpk.2	-	2	535	c.323A>T	c.(322-324)GAT>GTT	p.D108V	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Silent_p.R163R	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	108			D -> Y (in a head and neck tumor).|D -> H (in a bladder tumor).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.D108Y(14)|p.?(13)|p.D108H(9)|p.D108N(5)|p.H83fs*2(2)|p.D105fs*8(1)|p.A68fs*3(1)|p.R107fs*33(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		GCCCCAGGCATCGCGCACGTC	0.741		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			23	4					0	0	0	0
TAF1L	138474	broad.mit.edu	37	9	32633172	32633172	+	Silent	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr9:32633172G>A	uc003zrg.1	-	1	2496	c.2406C>T	c.(2404-2406)GGC>GGT	p.G802G	uc003zrh.1_5'Flank	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	802					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		GACACTGCTGGCCAACCACAA	0.423		NA											53	112					0	0	0	0
FOXB2	442425	broad.mit.edu	37	9	79634859	79634859	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr9:79634859T>A	uc004ako.1	+	1	289	c.289T>A	c.(289-291)TTC>ATC	p.F97I		NM_001013735	NP_001013757	Q5VYV0	FOXB2_HUMAN	forkhead box B2	97	Fork-head.				brain development|embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0						CGGGGACATGTTCGAGAACGG	0.652		NA											26	35					0	0	0	0
FLJ46321	389763	broad.mit.edu	37	9	84609214	84609214	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr9:84609214T>A	uc004amn.2	+	4	3876	c.3829T>A	c.(3829-3831)TGT>AGT	p.C1277S		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	1277						integral to membrane					0						GGTCCCTACCTGTGTCTTACA	0.552		NA											38	46					0	0	0	0
TBC1D2	55357	broad.mit.edu	37	9	101017708	101017708	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr9:101017708C>G	uc011lvb.1	-	1	296	c.116G>C	c.(115-117)CGG>CCG	p.R39P	TBC1D2_uc004ayq.2_Missense_Mutation_p.R39P|TBC1D2_uc004ayr.2_5'UTR|TBC1D2_uc004ayo.3_Missense_Mutation_p.R39P	NM_018421	NP_060891	Q9BYX2	TBD2A_HUMAN	TBC1 domain family, member 2	39	Interaction with CADH1.					cell junction|cytoplasmic membrane-bounded vesicle|nucleus	Rab GTPase activator activity			ovary(3)	3		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.55e-37)		CTCCAGGGACCGGGCGCAGTC	0.637		NA											14	30					0	0	0	0
COL15A1	1306	broad.mit.edu	37	9	101749627	101749627	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr9:101749627C>A	uc004azb.1	+	4	906	c.700C>A	c.(700-702)CTG>ATG	p.L234M		NM_001855	NP_001846	P39059	COFA1_HUMAN	alpha 1 type XV collagen precursor	234	Nonhelical region 1 (NC1).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			ovary(6)	6		Acute lymphoblastic leukemia(62;0.0562)				TCCCGAGGAGCTGTGTGACCC	0.642		NA											21	160					1.56e-14	2.12e-14	1	0
KIF12	113220	broad.mit.edu	37	9	116858353	116858353	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr9:116858353G>C	uc004bif.2	-	6	697	c.459C>G	c.(457-459)ATC>ATG	p.I153M	KIF12_uc004big.2_RNA	NM_138424	NP_612433	Q96FN5	KIF12_HUMAN	kinesin family member 12	286	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity				0						GGCTTCGGTTGATGCTGTTAG	0.617		NA											39	68					0	0	0	0
TLR4	7099	broad.mit.edu	37	9	120476132	120476132	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr9:120476132C>A	uc004bjz.2	+	3	2017	c.1726C>A	c.(1726-1728)CTT>ATT	p.L576I	TLR4_uc004bka.2_Missense_Mutation_p.L536I|TLR4_uc004bkb.2_Missense_Mutation_p.L376I	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	576	Extracellular (Potential).				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						TTTCTTAAATCTTACTCAGAA	0.413		NA											17	34					0.000422831	0.0004635	1	0
SPTAN1	6709	broad.mit.edu	37	9	131331097	131331097	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr9:131331097A>T	uc004bvl.3	+	3	397	c.284A>T	c.(283-285)AAC>ATC	p.N95I	SPTAN1_uc011mbg.1_Missense_Mutation_p.N95I|SPTAN1_uc011mbh.1_Missense_Mutation_p.N107I|SPTAN1_uc004bvm.3_Missense_Mutation_p.N95I|SPTAN1_uc004bvn.3_Missense_Mutation_p.N95I	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	95	Spectrin 2.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						GTGCAGGCCAACTCAGGAGCC	0.488		NA											54	9					0	0	0	0
RXRA	6256	broad.mit.edu	37	9	137293648	137293648	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr9:137293648G>T	uc004cfb.2	+	2	361	c.199G>T	c.(199-201)GTC>TTC	p.V67F	RXRA_uc004cfa.1_Missense_Mutation_p.G117V	NM_002957	NP_002948	P19793	RXRA_HUMAN	retinoid X receptor, alpha	67	Modulating (By similarity).				cellular lipid metabolic process|cholesterol metabolic process|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid|vitamin metabolic process	nuclear chromatin|nucleoplasm	enzyme binding|ligand-regulated transcription factor activity|protein heterodimerization activity|retinoic acid-responsive element binding|retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|transcription coactivator activity|vitamin D receptor binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(145;4.66e-08)|Epithelial(140;6.72e-08)|all cancers(34;2.22e-07)	Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)	GCCTTTCTCGGTCATCAGCTC	0.647		NA											124	40					4.57e-79	7.18e-79	1	0
OLFM1	10439	broad.mit.edu	37	9	137998625	137998625	+	Missense_Mutation	SNP	C	C	A	rs146984036		TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr9:137998625C>A	uc010nar.2	+	5	1023	c.707C>A	c.(706-708)CCC>CAC	p.P236H	OLFM1_uc004cfl.3_Missense_Mutation_p.P218H|OLFM1_uc004cfn.3_5'UTR	NM_014279	NP_055094	Q99784	NOE1_HUMAN	olfactomedin related ER localized protein	236	Olfactomedin-like.				nervous system development	endoplasmic reticulum lumen	protein binding	p.P218L(1)		ovary(1)|skin(1)	2		Myeloproliferative disorder(178;0.0333)		Epithelial(140;5.49e-08)|OV - Ovarian serous cystadenocarcinoma(145;9.68e-08)|all cancers(34;1.88e-07)		ATCAGTGACCCCGTGACTGTC	0.527		NA											15	10					3.41e-10	4.34e-10	1	0
SNAPC4	6621	broad.mit.edu	37	9	139282935	139282935	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr9:139282935G>T	uc004chh.2	-	10	1093	c.1084C>A	c.(1084-1086)CAG>AAG	p.Q362K		NM_003086	NP_003077	Q5SXM2	SNPC4_HUMAN	small nuclear RNA activating complex,	362	Myb-like 2.				snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter	snRNA-activating protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.31e-06)|Epithelial(140;7.13e-06)		CGCATCTCCTGCACCAGCTGC	0.622		NA											14	46					9.31e-06	1.07e-05	1	0
MXRA5	25878	broad.mit.edu	37	X	3235181	3235181	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:3235181T>A	uc004crg.3	-	6	6698	c.6541A>T	c.(6541-6543)AGG>TGG	p.R2181W		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	2181	Ig-like C2-type 6.					extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GACGGCAGCCTCCAGAGGATG	0.652		NA											3	8					0	0	0	0
NLGN4X	57502	broad.mit.edu	37	X	5821198	5821198	+	Silent	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:5821198G>T	uc010ndh.2	-	5	2022	c.1521C>A	c.(1519-1521)CTC>CTA	p.L507L	NLGN4X_uc004crp.2_Silent_p.L527L|NLGN4X_uc004crq.2_Silent_p.L507L|NLGN4X_uc010ndi.2_Silent_p.L544L|NLGN4X_uc004crr.2_Silent_p.L507L|NLGN4X_uc010ndj.2_Silent_p.L507L	NM_181332	NP_851849	Q8N0W4	NLGNX_HUMAN	X-linked neuroligin 4 precursor	507	Extracellular (Potential).				brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						TACAACTGAAGAGCTCGGTGG	0.537		NA											17	53					3.46e-05	3.91e-05	1	0
FAM9B	171483	broad.mit.edu	37	X	8997416	8997416	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:8997416G>A	uc011mhu.1	-	5	414	c.325C>T	c.(325-327)CTT>TTT	p.L109F	FAM9B_uc011mhv.1_RNA|FAM9B_uc004csh.2_Missense_Mutation_p.L149F	NM_205849	NP_995321	Q8IZU0	FAM9B_HUMAN	family with sequence similarity 9, member B	109						nucleus					0		Hepatocellular(5;0.219)				TATTCTTCAAGGACATTTAGC	0.289		NA											4	25					0	0	0	0
SHROOM2	357	broad.mit.edu	37	X	9862691	9862691	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:9862691G>T	uc004csu.1	+	4	833	c.743G>T	c.(742-744)GGT>GTT	p.G248V		NM_001649	NP_001640	Q13796	SHRM2_HUMAN	apical protein of Xenopus-like	248					apical protein localization|brain development|cell migration|cell morphogenesis|cellular pigment accumulation|ear development|establishment of melanosome localization|eye pigment granule organization|lens morphogenesis in camera-type eye|melanosome organization	apical plasma membrane|cell-cell adherens junction|microtubule|tight junction	actin filament binding|beta-catenin binding|ligand-gated sodium channel activity			ovary(3)|skin(3)|upper_aerodigestive_tract(1)|breast(1)	8		Hepatocellular(5;0.000888)				CCCAGGCAGGGTGGCCGGCAG	0.667		NA											3	13					2.56e-06	3e-06	1	0
FRMPD4	9758	broad.mit.edu	37	X	12632926	12632926	+	Silent	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:12632926G>A	uc004cuz.1	+	4	854	c.348G>A	c.(346-348)CCG>CCA	p.P116P	FRMPD4_uc011mij.1_Silent_p.P108P	NM_014728	NP_055543	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	116	PDZ.				positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			central_nervous_system(5)|ovary(3)|skin(2)|large_intestine(1)|lung(1)|pancreas(1)	13						AGCTGATCCCGGGAGATCAGA	0.517		NA											21	73					0	0	0	0
TLR7	51284	broad.mit.edu	37	X	12905663	12905663	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:12905663A>G	uc004cvc.2	+	3	2175	c.2036A>G	c.(2035-2037)AAT>AGT	p.N679S		NM_016562	NP_057646	Q9NYK1	TLR7_HUMAN	toll-like receptor 7 precursor	679	Extracellular (Potential).|LRR 23.				cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity			ovary(2)|lung(2)|breast(1)	5					Imiquimod(DB00724)	AATCTAAAGAATCTCTCTTTG	0.393		NA											40	131					0	0	0	0
BMX	660	broad.mit.edu	37	X	15543445	15543445	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:15543445C>G	uc004cww.2	+	8	975	c.787C>G	c.(787-789)CAA>GAA	p.Q263E	BMX_uc004cwx.3_Missense_Mutation_p.Q263E|BMX_uc004cwy.3_Missense_Mutation_p.Q263E	NM_203281	NP_975010	P51813	BMX_HUMAN	BMX non-receptor tyrosine kinase	263					cellular component disassembly involved in apoptosis|intracellular signal transduction|mesoderm development	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding|signal transducer activity			lung(3)|ovary(2)	5	Hepatocellular(33;0.183)					AAGCAGTAACCAAAAAGAAAG	0.313		NA											15	68					0	0	0	0
CDKL5	6792	broad.mit.edu	37	X	18622489	18622489	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:18622489A>G	uc004cym.2	+	12	1698	c.1445A>G	c.(1444-1446)TAC>TGC	p.Y482C	CDKL5_uc004cyn.2_Missense_Mutation_p.Y482C	NM_003159	NP_003150	O76039	CDKL5_HUMAN	cyclin-dependent kinase-like 5	482					neuron migration|positive regulation of axon extension|positive regulation of dendrite morphogenesis|positive regulation of Rac GTPase activity|protein autophosphorylation	dendrite cytoplasm|dendritic growth cone|nucleus	ATP binding|cyclin-dependent protein kinase activity|Rac GTPase binding			ovary(2)|large_intestine(1)|stomach(1)|central_nervous_system(1)|skin(1)	6	Hepatocellular(33;0.183)					AGTCCCTCCTACAGGACCAAG	0.532		NA											21	114					0	0	0	0
ACOT9	23597	broad.mit.edu	37	X	23723192	23723192	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:23723192G>A	uc004dap.2	-	13	1144	c.998C>T	c.(997-999)TCT>TTT	p.S333F	ACOT9_uc004dan.2_Missense_Mutation_p.S83F|ACOT9_uc004dao.2_Missense_Mutation_p.S342F|ACOT9_uc004daq.2_Missense_Mutation_p.S291F|ACOT9_uc004dar.2_Missense_Mutation_p.S273F|ACOT9_uc011mjt.1_RNA|ACOT9_uc004das.2_Missense_Mutation_p.S273F	NM_001033583	NP_001028755	Q9Y305	ACOT9_HUMAN	acyl-Coenzyme A thioesterase 2, mitochondrial	333					acyl-CoA metabolic process	mitochondrion	acetyl-CoA hydrolase activity|carboxylesterase activity			ovary(2)|pancreas(1)	3						AAACGGTCGAGAACCACTGTT	0.408		NA											46	68					0	0	0	0
MAGEB4	4115	broad.mit.edu	37	X	30260834	30260834	+	Silent	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:30260834C>A	uc004dcb.2	+	1	666	c.582C>A	c.(580-582)ACC>ACA	p.T194T	MAGEB1_uc004dcc.2_5'Flank|MAGEB1_uc004dcd.2_5'Flank	NM_002367	NP_002358	O15481	MAGB4_HUMAN	melanoma antigen family B, 4	194	MAGE.									ovary(1)	1						GTGCCTGGACCCTTCCAAGGA	0.522		NA											16	17					0.00316338	0.00337111	1	0
NR0B1	190	broad.mit.edu	37	X	30326619	30326619	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:30326619G>T	uc004dcf.3	-	1	877	c.862C>A	c.(862-864)CGC>AGC	p.R288S		NM_000475	NP_000466	P51843	NR0B1_HUMAN	nuclear receptor subfamily 0, group B, member 1	288	Ligand-binding (By similarity).				adrenal gland development|hypothalamus development|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of steroid hormone receptor signaling pathway|pituitary gland development|protein localization|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|steroid biosynthetic process	cytoplasm|membrane fraction|nucleoplasm|nucleus|polysomal ribosome	AF-2 domain binding|DNA hairpin binding|ligand-regulated transcription factor activity|protein domain specific binding|protein homodimerization activity|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|steroid hormone receptor binding|transcription corepressor activity|transcription factor binding			ovary(1)|lung(1)	2					Dexamethasone(DB01234)|Tretinoin(DB00755)	CAGCAGTTGCGCACCAGCACC	0.632		NA									OREG0019719	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	7					2.56e-06	3e-06	1	0
NR0B1	190	broad.mit.edu	37	X	30327199	30327199	+	Silent	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:30327199C>T	uc004dcf.3	-	1	297	c.282G>A	c.(280-282)CCG>CCA	p.P94P		NM_000475	NP_000466	P51843	NR0B1_HUMAN	nuclear receptor subfamily 0, group B, member 1	94	4 X 67 AA tandem repeats.|2.				adrenal gland development|hypothalamus development|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of steroid hormone receptor signaling pathway|pituitary gland development|protein localization|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|steroid biosynthetic process	cytoplasm|membrane fraction|nucleoplasm|nucleus|polysomal ribosome	AF-2 domain binding|DNA hairpin binding|ligand-regulated transcription factor activity|protein domain specific binding|protein homodimerization activity|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|steroid hormone receptor binding|transcription corepressor activity|transcription factor binding			ovary(1)|lung(1)	2					Dexamethasone(DB01234)|Tretinoin(DB00755)	CGGGCGCCTTCGGTGCCGCGT	0.687		NA											16	18					0	0	0	0
CXorf59	286464	broad.mit.edu	37	X	36122647	36122647	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:36122647G>T	uc004ddk.1	+	8	1070	c.884G>T	c.(883-885)TGC>TTC	p.C295F		NM_173695	NP_775966	Q8N9S7	CX059_HUMAN	hypothetical protein LOC286464	295						integral to membrane				central_nervous_system(1)	1						GTGCCATACTGCAGCAATAAT	0.343		NA											23	92					6.07e-21	8.83e-21	1	0
CXorf38	159013	broad.mit.edu	37	X	40498350	40498350	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:40498350G>T	uc004dew.2	-	3	387	c.382C>A	c.(382-384)CAA>AAA	p.Q128K	CXorf38_uc011mko.1_Intron|CXorf38_uc004dev.1_Missense_Mutation_p.Q9K|CXorf38_uc010nhd.2_RNA	NM_144970	NP_659407	Q8TB03	CX038_HUMAN	hypothetical protein LOC159013	128										ovary(1)	1						TCAGGTCCTTGTTTGTCTGCT	0.498		NA											13	75					6.72e-11	8.67e-11	1	0
ZNF157	7712	broad.mit.edu	37	X	47272966	47272966	+	Silent	SNP	T	T	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:47272966T>G	uc004dhr.1	+	4	1563	c.1494T>G	c.(1492-1494)CGT>CGG	p.R498R		NM_003446	NP_003437	P51786	ZN157_HUMAN	zinc finger protein 157	498					negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						GGTCCTGGCGTTGTACAATGA	0.502		NA											20	79					0	0	0	0
PORCN	64840	broad.mit.edu	37	X	48370283	48370283	+	Silent	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:48370283G>A	uc010nie.1	+	4	491	c.333G>A	c.(331-333)GAG>GAA	p.E111E	PORCN_uc004djq.1_Silent_p.E224E|PORCN_uc004djr.1_Silent_p.E111E|PORCN_uc004djs.1_Silent_p.E111E|PORCN_uc004djt.1_Silent_p.E40E|PORCN_uc011mlx.1_Silent_p.E40E|PORCN_uc004dju.1_5'UTR|PORCN_uc004djv.1_Silent_p.E111E|PORCN_uc004djw.1_Silent_p.E111E	NM_203475	NP_982301	Q9H237	PORCN_HUMAN	porcupine isoform D	111	Helical; (Potential).				Wnt receptor signaling pathway	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity			ovary(2)|central_nervous_system(1)	3						TCCTCAGTGAGATGCACATGG	0.597		NA									OREG0019764	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	61					0	0	0	0
HDAC6	10013	broad.mit.edu	37	X	48678561	48678561	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:48678561G>T	uc011mmi.1	+	23	2331	c.2236G>T	c.(2236-2238)GGG>TGG	p.G746W	HDAC6_uc004dks.1_Missense_Mutation_p.G746W|HDAC6_uc010nig.1_Missense_Mutation_p.G594W|HDAC6_uc004dkt.1_Missense_Mutation_p.G746W|HDAC6_uc011mmk.1_Missense_Mutation_p.G727W|HDAC6_uc004dkv.1_Missense_Mutation_p.G394W|HDAC6_uc004dkw.1_Missense_Mutation_p.G394W|HDAC6_uc004dkx.1_Missense_Mutation_p.G109W	NM_006044	NP_006035	Q9UBN7	HDAC6_HUMAN	histone deacetylase 6	746	Histone deacetylase 2.				aggresome assembly|cellular response to hydrogen peroxide|Hsp90 deacetylation|lysosome localization|macroautophagy|misfolded or incompletely synthesized protein catabolic process|negative regulation of proteolysis|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|polyubiquitinated misfolded protein transport|positive regulation of apoptosis|positive regulation of cellular chaperone-mediated protein complex assembly|positive regulation of epithelial cell migration|positive regulation of receptor biosynthetic process|positive regulation of signal transduction|regulation of androgen receptor signaling pathway|regulation of receptor activity|response to growth factor stimulus|response to toxin|transcription, DNA-dependent|tubulin deacetylation	aggresome|caveola|cell leading edge|cytosol|histone deacetylase complex|microtubule associated complex|perinuclear region of cytoplasm	actin binding|alpha-tubulin binding|beta-catenin binding|dynein complex binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|Hsp90 protein binding|microtubule binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|polyubiquitin binding|tau protein binding|tubulin deacetylase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)	4					Vorinostat(DB02546)	TGCTGCACGGGGGGATCCGCT	0.572		NA											15	74					1.15e-07	1.38e-07	1	0
HDAC6	10013	broad.mit.edu	37	X	48681696	48681696	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:48681696G>C	uc011mmi.1	+	25	2982	c.2887G>C	c.(2887-2889)GAC>CAC	p.D963H	HDAC6_uc004dks.1_Missense_Mutation_p.D963H|HDAC6_uc010nig.1_Missense_Mutation_p.D811H|HDAC6_uc004dkt.1_Missense_Mutation_p.D963H|HDAC6_uc011mmk.1_Missense_Mutation_p.D944H|HDAC6_uc004dkv.1_Missense_Mutation_p.D611H|HDAC6_uc004dkw.1_Missense_Mutation_p.D611H|HDAC6_uc004dkx.1_Missense_Mutation_p.D326H	NM_006044	NP_006035	Q9UBN7	HDAC6_HUMAN	histone deacetylase 6	963					aggresome assembly|cellular response to hydrogen peroxide|Hsp90 deacetylation|lysosome localization|macroautophagy|misfolded or incompletely synthesized protein catabolic process|negative regulation of proteolysis|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|polyubiquitinated misfolded protein transport|positive regulation of apoptosis|positive regulation of cellular chaperone-mediated protein complex assembly|positive regulation of epithelial cell migration|positive regulation of receptor biosynthetic process|positive regulation of signal transduction|regulation of androgen receptor signaling pathway|regulation of receptor activity|response to growth factor stimulus|response to toxin|transcription, DNA-dependent|tubulin deacetylation	aggresome|caveola|cell leading edge|cytosol|histone deacetylase complex|microtubule associated complex|perinuclear region of cytoplasm	actin binding|alpha-tubulin binding|beta-catenin binding|dynein complex binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|Hsp90 protein binding|microtubule binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|polyubiquitin binding|tau protein binding|tubulin deacetylase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)	4					Vorinostat(DB02546)	AGCCATTCTGGACCAGACCAC	0.647		NA											3	14					0	0	0	0
SLC35A2	7355	broad.mit.edu	37	X	48762559	48762559	+	Silent	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:48762559G>A	uc004dlo.1	-	4	631	c.627C>T	c.(625-627)TCC>TCT	p.S209S	SLC35A2_uc011mml.1_Silent_p.S222S|SLC35A2_uc004dlp.1_Silent_p.S209S|SLC35A2_uc011mmm.1_Silent_p.S237S|SLC35A2_uc011mmn.1_Silent_p.S148S|SLC35A2_uc004dlr.1_Intron|SLC35A2_uc004dlq.2_Intron	NM_005660	NP_005651	P78381	S35A2_HUMAN	solute carrier family 35, member A2 isoform a	209	Helical; (Potential).				galactose metabolic process	Golgi membrane|integral to membrane|nucleus	sugar:hydrogen symporter activity|UDP-galactose transmembrane transporter activity			breast(1)	1						AGGAGAGACAGGAGGCCACGA	0.647		NA											9	7					0	0	0	0
GPKOW	27238	broad.mit.edu	37	X	48979050	48979051	+	Silent	DNP	GG	GG	TT			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:48979050_48979051GG>TT	uc004dmr.2	-	2	259_260	c.252_253CC>AA	c.(250-255)GCCCGG>GCAAGG	p.84_85AR>AR		NM_015698	NP_056513	Q92917	GPKOW_HUMAN	G patch domain and KOW motifs	84_85						nucleus	nucleic acid binding			ovary(2)	2						CCAGGGGGCCGGGCTGGTGGCT	0.629		NA											12	23					0	0	0	0
CCDC22	28952	broad.mit.edu	37	X	49099871	49099871	+	Silent	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:49099871C>T	uc004dnd.1	+	6	813	c.657C>T	c.(655-657)GGC>GGT	p.G219G	CCDC22_uc011mna.1_Silent_p.G219G|CCDC22_uc004dnc.1_RNA	NM_014008	NP_054727	O60826	CCD22_HUMAN	coiled-coil domain containing 22	219										central_nervous_system(1)	1						AGCAGACGGGCCGGGACCGGC	0.682		NA											7	13					0	0	0	0
GAGE10	643832	broad.mit.edu	37	X	49173663	49173663	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:49173663G>C	uc010nir.1	+	4	340	c.224G>C	c.(223-225)AGC>ACC	p.S75T	GAGE10_uc010nis.2_RNA	NM_001098413	NP_001091883	A6NGK3	GAG10_HUMAN	G antigen 10	75											0	Ovarian(276;0.236)					GAAGCTGATAGCCAGGAACAG	0.423		NA											68	152					0	0	0	0
AKAP4	8852	broad.mit.edu	37	X	49958928	49958928	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:49958928C>A	uc004dow.1	-	5	560	c.436G>T	c.(436-438)GAA>TAA	p.E146*	AKAP4_uc004dov.1_Nonsense_Mutation_p.E137*|AKAP4_uc010njp.1_5'UTR|AKAP4_uc004dou.1_Nonsense_Mutation_p.E137*	NM_003886	NP_003877	Q5JQC9	AKAP4_HUMAN	A-kinase anchor protein 4 isoform 1	146				E -> D (in Ref. 2; AAC79433).	cell projection organization|single fertilization|sperm motility	cAMP-dependent protein kinase complex|cilium|cytoskeleton|microtubule-based flagellum	protein kinase A binding			kidney(3)|central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	8	Ovarian(276;0.236)					CTGTGATATTCGCCCTCTGTG	0.448		NA											55	46					5.39e-20	7.79e-20	1	0
IQSEC2	23096	broad.mit.edu	37	X	53276218	53276218	+	Silent	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:53276218G>A	uc004dsd.2	-	8	2883	c.2682C>T	c.(2680-2682)GAC>GAT	p.D894D	IQSEC2_uc004dsc.2_Silent_p.D689D	NM_001111125	NP_001104595	Q5JU85	IQEC2_HUMAN	IQ motif and Sec7 domain 2 isoform1	884	SEC7.				regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			ovary(3)	3						GACTGTACATGTCGGTATTGA	0.517		NA											9	46					0	0	0	0
RIBC1	158787	broad.mit.edu	37	X	53455483	53455483	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:53455483C>G	uc004dsk.2	+	5	605	c.452C>G	c.(451-453)ACA>AGA	p.T151R	RIBC1_uc004dsj.1_Missense_Mutation_p.T151R|RIBC1_uc011mog.1_Intron	NM_001031745	NP_001026915	Q8N443	RIBC1_HUMAN	RIB43A domain with coiled-coils 1 isoform 1	151											0						GACAGGGACACACGGCTGAGA	0.507		NA											14	18					0	0	0	0
HUWE1	10075	broad.mit.edu	37	X	53658553	53658553	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:53658553G>C	uc004dsp.2	-	10	1061	c.659C>G	c.(658-660)ACA>AGA	p.T220R		NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	220					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						ATAATGTAGTGTGTTACTAGT	0.378		NA											18	63					0	0	0	0
FAM123B	139285	broad.mit.edu	37	X	63413127	63413127	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:63413127C>T	uc004dvo.2	-	2	313	c.40G>A	c.(40-42)GCT>ACT	p.A14T		NM_152424	NP_689637	Q5JTC6	F123B_HUMAN	family with sequence similarity 123B	14					Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane		p.0?(40)		kidney(99)|large_intestine(6)|ovary(3)|lung(2)|breast(1)|liver(1)	112						GAGGCTGCAGCTCCCTTGGCC	0.557		NA											20	88					0	0	0	0
MSN	4478	broad.mit.edu	37	X	64957172	64957172	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:64957172G>T	uc004dwf.2	+	10	1421	c.1223G>T	c.(1222-1224)CGG>CTG	p.R408L		NM_002444	NP_002435	P26038	MOES_HUMAN	moesin	408					leukocyte cell-cell adhesion|leukocyte migration|membrane to membrane docking	apical plasma membrane|cytoskeleton|extrinsic to membrane|microvillus membrane|nucleolus	cell adhesion molecule binding|receptor binding|structural constituent of cytoskeleton		MSN/ALK(6)	haematopoietic_and_lymphoid_tissue(6)|ovary(3)|lung(1)	10						CAGGCCTCCCGGGACCAGAAA	0.542		NA	T	ALK	ALCL								5	13					1.24e-05	1.41e-05	1	0
ATRX	546	broad.mit.edu	37	X	76939151	76939151	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:76939151C>G	uc004ecp.3	-	9	1829	c.1597G>C	c.(1597-1599)GAG>CAG	p.E533Q	ATRX_uc004ecq.3_Missense_Mutation_p.E495Q|ATRX_uc004eco.3_Missense_Mutation_p.E318Q|ATRX_uc004ecr.2_Missense_Mutation_p.E494Q|ATRX_uc010nlx.1_Missense_Mutation_p.E533Q|ATRX_uc010nly.1_Missense_Mutation_p.E478Q	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	533					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	ATAGCAGTCTCAAGATTCTCA	0.393		NA	Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						159	124					0	0	0	0
KLHL4	56062	broad.mit.edu	37	X	86919890	86919890	+	Silent	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:86919890G>A	uc004efb.2	+	10	2234	c.2052G>A	c.(2050-2052)TTG>TTA	p.L684L	KLHL4_uc004efa.2_Silent_p.L684L	NM_019117	NP_061990	Q9C0H6	KLHL4_HUMAN	kelch-like 4 isoform 1	684	Kelch 6.					cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						ATACTTATTTGAACACAGTTG	0.383		NA											23	18					0	0	0	0
PCDH11X	27328	broad.mit.edu	37	X	91133291	91133292	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:91133291_91133292GG>TT	uc004efk.1	+	2	2897_2898	c.2052_2053GG>TT	c.(2050-2055)TTGGTT>TTTTTT	p.684_685LV>FF	PCDH11X_uc004efl.1_Missense_Mutation_p.684_685LV>FF|PCDH11X_uc004efo.1_Missense_Mutation_p.684_685LV>FF|PCDH11X_uc010nmv.1_Missense_Mutation_p.684_685LV>FF|PCDH11X_uc004efm.1_Missense_Mutation_p.684_685LV>FF|PCDH11X_uc004efn.1_Missense_Mutation_p.684_685LV>FF|PCDH11X_uc004efh.1_Missense_Mutation_p.684_685LV>FF|PCDH11X_uc004efj.1_Missense_Mutation_p.684_685LV>FF	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	684_685	Cadherin 7.|Extracellular (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						CTTATGAATTGGTTCTACCGTC	0.426		NA											73	53					0	0	0	0
TEX13A	56157	broad.mit.edu	37	X	104463830	104463830	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:104463830G>T	uc004ema.2	-	5	1158	c.1046C>A	c.(1045-1047)CCC>CAC	p.P349H	IL1RAPL2_uc004elz.1_Intron|TEX13A_uc004emb.2_Missense_Mutation_p.P350T	NM_031274	NP_112564	Q9BXU3	TX13A_HUMAN	testis expressed sequence 13A	349						intracellular	zinc ion binding			ovary(2)	2						TATTCTGTGGGGCCCCCCATC	0.567		NA											46	26					5.34e-22	7.83e-22	1	0
DCX	1641	broad.mit.edu	37	X	110654066	110654066	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:110654066A>G	uc004epd.2	-	1	309	c.137T>C	c.(136-138)GTT>GCT	p.V46A	DCX_uc011msv.1_Missense_Mutation_p.V46A|DCX_uc004epe.2_Intron|DCX_uc004epf.2_Intron|DCX_uc004epg.2_Intron	NM_000555	NP_000546	O43602	DCX_HUMAN	doublecortin isoform a	46					axon guidance|central nervous system development|intracellular signal transduction	cytosol|microtubule associated complex	microtubule binding			central_nervous_system(2)|lung(1)|skin(1)	4						CACATGACTAACAGTTGTAAA	0.428		NA											107	64					0	0	0	0
TRPC5	7224	broad.mit.edu	37	X	111090412	111090412	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:111090412T>A	uc004epl.1	-	6	2549	c.1630A>T	c.(1630-1632)ACC>TCC	p.T544S	TRPC5_uc004epm.1_Missense_Mutation_p.T544S	NM_012471	NP_036603	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel,	544	Extracellular (Potential).				axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			urinary_tract(1)	1						ATAGCTCTGGTTTCATAATAG	0.433		NA											54	36					0	0	0	0
ARHGAP36	158763	broad.mit.edu	37	X	130220339	130220339	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:130220339G>T	uc004evz.2	+	10	1663	c.1318G>T	c.(1318-1320)GTG>TTG	p.V440L	ARHGAP36_uc004ewa.2_Missense_Mutation_p.V428L|ARHGAP36_uc004ewb.2_Missense_Mutation_p.V409L|ARHGAP36_uc004ewc.2_Missense_Mutation_p.V304L	NM_144967	NP_659404	Q6ZRI8	RHG36_HUMAN	hypothetical protein LOC158763 precursor	440					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)	3						TGCTAAGCGCGTGTGGAAGTC	0.453		NA											27	27					2.08e-15	2.87e-15	1	0
GPR112	139378	broad.mit.edu	37	X	135429618	135429618	+	Silent	SNP	C	C	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:135429618C>A	uc004ezu.1	+	6	4044	c.3753C>A	c.(3751-3753)ACC>ACA	p.T1251T	GPR112_uc010nsb.1_Silent_p.T1046T|GPR112_uc010nsc.1_Silent_p.T1018T	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	1251	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					TGACTAGCACCTCTGTCTTAT	0.433		NA											16	123					0.00498961	0.00526838	1	0
GPR112	139378	broad.mit.edu	37	X	135431250	135431250	+	Silent	SNP	T	T	G			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:135431250T>G	uc004ezu.1	+	6	5676	c.5385T>G	c.(5383-5385)ACT>ACG	p.T1795T	GPR112_uc010nsb.1_Silent_p.T1590T|GPR112_uc010nsc.1_Silent_p.T1562T	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	1795	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					CTTCTAATACTAGAAAGATGA	0.398		NA											31	111					0	0	0	0
BRS3	680	broad.mit.edu	37	X	135574475	135574475	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:135574475G>A	uc004ezv.1	+	3	1290	c.1141G>A	c.(1141-1143)GAA>AAA	p.E381K		NM_001727	NP_001718	P32247	BRS3_HUMAN	bombesin-like receptor 3	381	Cytoplasmic (Potential).				adult feeding behavior|glucose metabolic process|regulation of blood pressure	integral to membrane|plasma membrane	bombesin receptor activity			ovary(1)	1	Acute lymphoblastic leukemia(192;0.000127)					ACAGATGTCTGAAATTAGTGT	0.542		NA											13	77					0	0	0	0
RAB39B	116442	broad.mit.edu	37	X	154493403	154493403	+	Silent	SNP	G	G	C			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:154493403G>C	uc004fne.2	-	1	450	c.171C>G	c.(169-171)CGC>CGG	p.R57R		NM_171998	NP_741995	Q96DA2	RB39B_HUMAN	RAB39B, member RAS oncogene family	57				R -> T (in Ref. 1; AAL12244).	protein transport|small GTPase mediated signal transduction|synapse organization|vesicle-mediated transport	Golgi apparatus|plasma membrane	GTP binding				0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					GGAGCTTGATGCGTTTTCCTG	0.622		NA											34	24					0	0	0	0
CNST	163882	broad.mit.edu	37	1	246784843	246784844	+	Frame_Shift_Ins	INS	-	-	GC			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:246784843_246784844insGC	uc001ibp.2	+	3	870_871	c.492_493insGC	c.(490-495)GAGGCGfs	p.E164fs	CNST_uc001ibo.3_Frame_Shift_Ins_p.E164fs	NM_152609	NP_689822	Q6PJW8	CNST_HUMAN	hypothetical protein LOC163882 isoform 1	164_165					positive regulation of Golgi to plasma membrane protein transport	integral to membrane|plasma membrane|protein complex|trans-Golgi network|transport vesicle	connexin binding				0						AGCAGCCAGAGGCGCCAAAGCT	0.441		NA											134	214	---	---	---	---	NA	NA	NA	NA
OR2T12	127064	broad.mit.edu	37	1	248458101	248458101	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr1:248458101delG	uc010pzj.1	-	1	780	c.780delC	c.(778-780)CCCfs	p.P260fs		NM_001004692	NP_001004692	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T,	260	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			TGTGGGATTTGGGTCTCATAT	0.483		NA											52	96	---	---	---	---	NA	NA	NA	NA
NET1	10276	broad.mit.edu	37	10	5498668	5498668	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr10:5498668delC	uc001iia.2	+	12	1640	c.1502delC	c.(1501-1503)GCCfs	p.A501fs	NET1_uc010qar.1_Frame_Shift_Del_p.A320fs|NET1_uc001iib.2_Frame_Shift_Del_p.A447fs|NET1_uc010qas.1_Frame_Shift_Del_p.A320fs	NM_001047160	NP_001040625	Q7Z628	ARHG8_HUMAN	neuroepithelial cell transforming gene 1 isoform	501	PH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell growth|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|nucleus	Rho guanyl-nucleotide exchange factor activity			breast(1)	1						GCGGCCATTGCCCCCTTCCAG	0.602		NA											42	25	---	---	---	---	NA	NA	NA	NA
MRGPRX3	117195	broad.mit.edu	37	11	18158862	18158862	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr11:18158862delC	uc001mnu.2	+	3	474	c.113delC	c.(112-114)TCCfs	p.S38fs		NM_054031	NP_473372	Q96LB0	MRGX3_HUMAN	MAS-related GPR, member X3	38	Helical; Name=1; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|pancreas(1)	2						TGCATCGTTTCCCTTGTCGCG	0.592		NA											78	164	---	---	---	---	NA	NA	NA	NA
MCF2L	23263	broad.mit.edu	37	13	113729415	113729415	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr13:113729415delG	uc001vsu.2	+	11	1413	c.1391delG	c.(1390-1392)CGGfs	p.R464fs	MCF2L_uc001vsq.2_Frame_Shift_Del_p.R464fs|MCF2L_uc010tjr.1_Frame_Shift_Del_p.R407fs|MCF2L_uc001vsr.2_Frame_Shift_Del_p.R411fs|MCF2L_uc001vss.3_Frame_Shift_Del_p.R405fs|MCF2L_uc010tjs.1_Frame_Shift_Del_p.R405fs|MCF2L_uc001vst.1_Frame_Shift_Del_p.R369fs	NM_001112732	NP_001106203	O15068	MCF2L_HUMAN	MCF.2 cell line derived transforming	437	Spectrin.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	Rho guanyl-nucleotide exchange factor activity			ovary(1)|kidney(1)	2	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0368)|all_epithelial(44;0.0396)|Lung NSC(25;0.129)|Breast(118;0.188)				CAGGAGCTCCGGCACCTCTGT	0.667		NA											45	26	---	---	---	---	NA	NA	NA	NA
EFS	10278	broad.mit.edu	37	14	23826490	23826491	+	Frame_Shift_Del	DEL	TC	TC	-			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr14:23826490_23826491delTC	uc001wjo.2	-	6	2238_2239	c.1630_1631delGA	c.(1630-1632)GAAfs	p.E544fs	EFS_uc001wjp.2_Frame_Shift_Del_p.E451fs|EFS_uc010tnm.1_Frame_Shift_Del_p.E375fs	NM_005864	NP_005855	O43281	EFS_HUMAN	embryonal Fyn-associated substrate isoform 1	544					cell adhesion|intracellular signal transduction	cytoplasm	SH3 domain binding			large_intestine(1)	1	all_cancers(95;7.12e-06)			GBM - Glioblastoma multiforme(265;0.00649)		CCCTGCCAGTTCTGTTACACAC	0.619		NA											26	127	---	---	---	---	NA	NA	NA	NA
MYH4	4622	broad.mit.edu	37	17	10351938	10351938	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr17:10351938delG	uc002gmn.2	-	32	4639	c.4528delC	c.(4528-4530)CAAfs	p.Q1510fs	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	1510	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						GACTCACGTTGTAAGTTCTTA	0.378		NA											44	93	---	---	---	---	NA	NA	NA	NA
DPY19L3	147991	broad.mit.edu	37	19	32954307	32954307	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:32954307delA	uc002ntg.2	+	13	1534	c.1358delA	c.(1357-1359)GAAfs	p.E453fs	DPY19L3_uc002nth.1_Frame_Shift_Del_p.E453fs|DPY19L3_uc002nti.1_RNA	NM_207325	NP_997208	Q6ZPD9	D19L3_HUMAN	dpy-19-like 3	453						integral to membrane				ovary(4)	4	Esophageal squamous(110;0.162)					GGTAAAATGGAAAAAGGCACA	0.333		NA											46	60	---	---	---	---	NA	NA	NA	NA
SIGLEC14	100049587	broad.mit.edu	37	19	52149112	52149112	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr19:52149112delC	uc002pxf.3	-	3	743	c.623delG	c.(622-624)GGCfs	p.G208fs		NM_001098612	NP_001092082	Q08ET2	SIG14_HUMAN	sialic acid binding Ig-like lectin 14 precursor	208	Ig-like C2-type 1.|Extracellular (Potential).				cell adhesion	integral to membrane|plasma membrane	protein binding|sugar binding			ovary(1)	1		all_neural(266;0.0299)		GBM - Glioblastoma multiforme(134;0.000965)|OV - Ovarian serous cystadenocarcinoma(262;0.0195)		GAGGTTGGTGCCATGGTCCTC	0.637		NA											35	54	---	---	---	---	NA	NA	NA	NA
RAB22A	57403	broad.mit.edu	37	20	56929251	56929254	+	Frame_Shift_Del	DEL	TATT	TATT	-			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr20:56929251_56929254delTATT	uc002xyz.2	+	6	679_682	c.417_420delTATT	c.(415-420)TCTATTfs	p.S139fs		NM_020673	NP_065724	Q9UL26	RB22A_HUMAN	RAS-related protein RAB-22A	139_140					endocytosis|endosome organization|protein transport|small GTPase mediated signal transduction	early endosome|endosome membrane|plasma membrane	GTP binding|GTPase activity|protein binding				0	all_epithelial(3;5.09e-14)|Lung NSC(12;0.000122)|all_lung(29;0.00042)		BRCA - Breast invasive adenocarcinoma(13;6.2e-12)|Epithelial(14;4.73e-08)|all cancers(14;4.83e-07)			ACGCCGACTCTATTCATGCAATTT	0.402		NA											16	27	---	---	---	---	NA	NA	NA	NA
DOPEY2	9980	broad.mit.edu	37	21	37586451	37586452	+	Frame_Shift_Ins	INS	-	-	T	rs147590869	byFrequency	TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr21:37586451_37586452insT	uc002yvg.2	+	8	1056_1057	c.977_978insT	c.(976-978)TATfs	p.Y326fs	DOPEY2_uc011aeb.1_Frame_Shift_Ins_p.Y326fs	NM_005128	NP_005119	Q9Y3R5	DOP2_HUMAN	pad-1-like	326					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				ovary(1)|central_nervous_system(1)	2						CAGTCGTCTTATTTTTTTGAAA	0.396		NA											13	99	---	---	---	---	NA	NA	NA	NA
KRTAP10-9	386676	broad.mit.edu	37	21	46047615	46047615	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr21:46047615delC	uc002zfp.3	+	1	576	c.527delC	c.(526-528)TCCfs	p.S176fs	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198690	NP_941963	P60411	KR109_HUMAN	keratin associated protein 10-9	176	16.|25 X 5 AA repeats of C-C-X(3).					keratin filament					0						TGCACTTCCTCCCCCTGCCAG	0.552		NA											97	252	---	---	---	---	NA	NA	NA	NA
MICAL3	57553	broad.mit.edu	37	22	18300912	18300912	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr22:18300912delG	uc002zng.3	-	26	4868	c.4515delC	c.(4513-4515)CCCfs	p.P1505fs	MICAL3_uc011agl.1_Frame_Shift_Del_p.P1421fs|MICAL3_uc010gre.1_5'Flank	NM_015241	NP_056056	Q7RTP6	MICA3_HUMAN	microtubule associated monoxygenase, calponin	1505	Pro-rich.					cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding				0		all_epithelial(15;0.198)		Lung(27;0.0427)		CCTCCTCTCTGGGGGGCTGAG	0.652		NA											10	10	---	---	---	---	NA	NA	NA	NA
TFDP2	7029	broad.mit.edu	37	3	141682777	141682777	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr3:141682777delC	uc003eun.3	-	10	1140	c.761delG	c.(760-762)AGAfs	p.R254fs	TFDP2_uc003euk.3_Frame_Shift_Del_p.R167fs|TFDP2_uc010hur.2_Frame_Shift_Del_p.R194fs|TFDP2_uc003eul.3_Frame_Shift_Del_p.R194fs|TFDP2_uc011bnf.1_Frame_Shift_Del_p.R157fs|TFDP2_uc011bng.1_Frame_Shift_Del_p.R118fs|TFDP2_uc003eum.3_Frame_Shift_Del_p.R194fs	NM_006286	NP_006277	Q14188	TFDP2_HUMAN	transcription factor Dp-2 (E2F dimerization	254	Dimerization (Potential).|DCB1.				cell cycle	transcription factor complex	DNA binding|protein domain specific binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity|transcription factor binding			kidney(1)	1						TTGTCGATTTCTCTGTACCAG	0.368		NA											47	64	---	---	---	---	NA	NA	NA	NA
FAT1	2195	broad.mit.edu	37	4	187629115	187629116	+	Frame_Shift_Del	DEL	CC	CC	-			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr4:187629115_187629116delCC	uc003izf.2	-	2	2054_2055	c.1866_1867delGG	c.(1864-1869)GGGGTAfs	p.G622fs	FAT1_uc010iso.1_Frame_Shift_Del_p.G622fs	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	622_623	Extracellular (Potential).|Cadherin 5.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						AATGACAATACCCCCGAGTTGG	0.426		NA								HNSCC(5;0.00058)			29	27	---	---	---	---	NA	NA	NA	NA
GPRC6A	222545	broad.mit.edu	37	6	117130668	117130668	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr6:117130668delA	uc003pxj.1	-	2	329	c.307delT	c.(307-309)TGTfs	p.C103fs	GPRC6A_uc003pxk.1_Frame_Shift_Del_p.C103fs|GPRC6A_uc003pxl.1_Frame_Shift_Del_p.C103fs	NM_148963	NP_683766	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6,	103	Extracellular (Potential).				response to amino acid stimulus		G-protein coupled receptor activity			ovary(4)|skin(2)	6		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		ACTTCTGTACAAGTGTCATAG	0.408		NA											13	34	---	---	---	---	NA	NA	NA	NA
ZFHX4	79776	broad.mit.edu	37	8	77767550	77767550	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chr8:77767550delC	uc003yav.2	+	10	8645	c.8258delC	c.(8257-8259)ACCfs	p.T2753fs	ZFHX4_uc003yau.1_Frame_Shift_Del_p.T2798fs|ZFHX4_uc003yaw.1_Frame_Shift_Del_p.T2753fs	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2753						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CAAAATAAAACCGATTTTGAT	0.438		NA								HNSCC(33;0.089)			24	21	---	---	---	---	NA	NA	NA	NA
KLHL4	56062	broad.mit.edu	37	X	86890748	86890754	+	Frame_Shift_Del	DEL	GCTCCAG	GCTCCAG	-			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:86890748_86890754delGCTCCAG	uc004efb.2	+	9	2080_2086	c.1898_1904delGCTCCAG	c.(1897-1905)TGCTCCAGGfs	p.C633fs	KLHL4_uc004efa.2_Frame_Shift_Del_p.C633fs	NM_019117	NP_061990	Q9C0H6	KLHL4_HUMAN	kelch-like 4 isoform 1	633_635	Kelch 5.					cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						TCCAACCATTGCTCCAGGCTTTCTGAC	0.382		NA											11	22	---	---	---	---	NA	NA	NA	NA
DCX	1641	broad.mit.edu	37	X	110653517	110653517	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CR-7370-01A-11D-2129-08	TCGA-CR-7370-10A-01D-2129-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9f8ec337-85f7-4b01-a2b6-5db9a9e62f30	dd17d255-c853-4d2d-ad5e-cbec1719ca9d	g.chrX:110653517delA	uc004epd.2	-	2	525	c.353delT	c.(352-354)TTCfs	p.F118fs	DCX_uc011msv.1_Frame_Shift_Del_p.F118fs|DCX_uc004epe.2_Frame_Shift_Del_p.F37fs|DCX_uc004epf.2_Frame_Shift_Del_p.F37fs|DCX_uc004epg.2_Frame_Shift_Del_p.F37fs	NM_000555	NP_000546	O43602	DCX_HUMAN	doublecortin isoform a	118					axon guidance|central nervous system development|intracellular signal transduction	cytosol|microtubule associated complex	microtubule binding			central_nervous_system(2)|lung(1)|skin(1)	4						GGTTCGGTAGAAGCTACAGTG	0.512		NA											55	47	---	---	---	---	NA	NA	NA	NA