Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
TAS1R1	80835	broad.mit.edu	37	1	6635143	6635143	+	Silent	SNP	C	C	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr1:6635143C>T	uc001ant.2	+	3	951	c.951C>T	c.(949-951)CGC>CGT	p.R317R	TAS1R1_uc001anu.2_Intron|TAS1R1_uc001anv.2_Intron|TAS1R1_uc001anw.2_Silent_p.R317R	NM_138697	NP_619642	Q7RTX1	TS1R1_HUMAN	sweet taste receptor T1r isoform b	317	Extracellular (Potential).				sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;8.73e-34)|all_epithelial(116;9.26e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Breast(487;0.000353)|Renal(390;0.0007)|Colorectal(325;0.00104)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.29e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00108)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0642)		GGATCCAGCGCATTGGGATGG	0.642		NA											10	32					0	0	0	0
VPS13D	55187	broad.mit.edu	37	1	12326995	12326995	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr1:12326995G>A	uc001atv.2	+	14	1793	c.1652G>A	c.(1651-1653)CGG>CAG	p.R551Q	VPS13D_uc001atw.2_Missense_Mutation_p.R551Q	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	551					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		CTTTCAGTCCGGTTGGGTGGA	0.388		NA											16	35					0	0	0	0
TMEM39B	55116	broad.mit.edu	37	1	32557499	32557499	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr1:32557499C>T	uc010ogv.1	+	6	960	c.814C>T	c.(814-816)CGC>TGC	p.R272C	TMEM39B_uc010ogt.1_RNA|TMEM39B_uc010ogu.1_Missense_Mutation_p.R145C|TMEM39B_uc001bue.3_Missense_Mutation_p.R273C|TMEM39B_uc001buf.3_Missense_Mutation_p.R73C|TMEM39B_uc010ogw.1_Missense_Mutation_p.R73C	NM_018056	NP_060526	Q9GZU3	TM39B_HUMAN	transmembrane protein 39B	272						integral to membrane					0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				CAGCCTCATCCGCAGTGAGGT	0.597		NA											5	49					0	0	0	0
ELAVL4	1996	broad.mit.edu	37	1	50666696	50666696	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr1:50666696G>A	uc001csb.2	+	7	1257	c.989G>A	c.(988-990)CGT>CAT	p.R330H	ELAVL4_uc001cry.3_Missense_Mutation_p.R319H|ELAVL4_uc001crz.3_Missense_Mutation_p.R316H|ELAVL4_uc001csa.3_Missense_Mutation_p.R333H|ELAVL4_uc001csc.3_Missense_Mutation_p.R316H|ELAVL4_uc010omz.1_Missense_Mutation_p.R321H	NM_021952	NP_068771	P26378	ELAV4_HUMAN	ELAV-like 4 isoform 1	330	RRM 3.				mRNA processing		AU-rich element binding|mRNA 3'-UTR binding|nucleotide binding			ovary(1)|pancreas(1)	2						AAGGTGATTCGTGACTTCAAC	0.542		NA											10	68					0	0	0	0
C1orf177	163747	broad.mit.edu	37	1	55282673	55282673	+	Silent	SNP	T	T	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr1:55282673T>A	uc001cyb.3	+	9	1116	c.1062T>A	c.(1060-1062)GGT>GGA	p.G354G	C1orf177_uc001cya.3_Silent_p.G354G	NM_001110533	NP_001104003	Q3ZCV2	CA177_HUMAN	hypothetical protein LOC163747 isoform 2	354											0						ACCCAGTAGGTGTGGGCCGCT	0.572		NA											6	40					0	0	0	0
C8A	731	broad.mit.edu	37	1	57351627	57351627	+	Nonsense_Mutation	SNP	A	A	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr1:57351627A>T	uc001cyo.2	+	7	1015	c.883A>T	c.(883-885)AAG>TAG	p.K295*		NM_000562	NP_000553	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	295	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				ovary(1)|central_nervous_system(1)|skin(1)	3						AATCTTCACAAAGGTGCAGAC	0.368		NA											20	29					0	0	0	0
DAB1	1600	broad.mit.edu	37	1	57611078	57611078	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr1:57611078A>G	uc001cys.1	-	5	766	c.92T>C	c.(91-93)TTG>TCG	p.L31S	DAB1_uc001cyt.1_Missense_Mutation_p.L31S|DAB1_uc001cyq.1_Missense_Mutation_p.L31S|DAB1_uc001cyr.1_Missense_Mutation_p.L31S|DAB1_uc009vzw.1_Missense_Mutation_p.L31S|DAB1_uc009vzx.1_Missense_Mutation_p.L31S	NM_021080	NP_066566	O75553	DAB1_HUMAN	disabled homolog 1	31					cell differentiation|nervous system development					skin(2)|ovary(1)	3						CCTCTTTATCAAAGTGGCTTC	0.443		NA											5	47					0	0	0	0
COL24A1	255631	broad.mit.edu	37	1	86529426	86529426	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr1:86529426G>C	uc001dlj.2	-	8	1766	c.1724C>G	c.(1723-1725)CCT>CGT	p.P575R	COL24A1_uc010osd.1_5'UTR|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA|COL24A1_uc009wcq.2_Missense_Mutation_p.P575R	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	575	Collagen-like 2.				cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		TGGGAGTCCAGGATGTCCTTT	0.383		NA											20	103					0	0	0	0
COL11A1	1301	broad.mit.edu	37	1	103491099	103491099	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr1:103491099C>T	uc001dul.2	-	7	1286	c.968G>A	c.(967-969)AGG>AAG	p.R323K	COL11A1_uc001duk.2_5'UTR|COL11A1_uc001dum.2_Missense_Mutation_p.R335K|COL11A1_uc001dun.2_Missense_Mutation_p.R284K|COL11A1_uc009weh.2_Intron	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	323	Nonhelical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		AGAAACATGCCTAGGAGCTTC	0.328		NA											6	47					0	0	0	0
AMY2B	280	broad.mit.edu	37	1	104115869	104115869	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr1:104115869A>G	uc001duq.2	+	5	1116	c.500A>G	c.(499-501)AAT>AGT	p.N167S	AMY2B_uc010ouo.1_RNA|LOC648740_uc001dur.2_Missense_Mutation_p.N167S|AMY2B_uc001dus.1_5'Flank	NM_020978	NP_066188	P19961	AMY2B_HUMAN	amylase, pancreatic, alpha-2B precursor	167					carbohydrate metabolic process|digestion	extracellular region	alpha-amylase activity|metal ion binding				0		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0669)|all cancers(265;0.083)|Epithelial(280;0.094)|Lung(183;0.112)		GAGAACTACAATGATGCTACT	0.358		NA											43	352					0	0	0	0
HSD3B2	3284	broad.mit.edu	37	1	119962178	119962178	+	Missense_Mutation	SNP	G	G	A	rs6211	byFrequency	TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr1:119962178G>A	uc001ehs.2	+	2	1053	c.280G>A	c.(280-282)GAG>AAG	p.E94K	HSD3B2_uc001eht.2_Missense_Mutation_p.E94K|HSD3B2_uc001ehu.2_Missense_Mutation_p.E94K	NM_000198	NP_000189	P26439	3BHS2_HUMAN	3 beta-hydroxysteroid dehydrogenase 2	94				HRE -> RRQ (in Ref. 8; AAD14329).	androgen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			ovary(2)	2	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.015)|LUSC - Lung squamous cell carcinoma(189;0.0836)	NADH(DB00157)|Trilostane(DB01108)	CACTCACAGAGAGTCCATCAT	0.463		NA											6	56					0	0	0	0
PIAS3	10401	broad.mit.edu	37	1	145581554	145581554	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr1:145581554A>G	uc001eoc.1	+	9	1226	c.1135A>G	c.(1135-1137)ATC>GTC	p.I379V	NBPF10_uc001emp.3_Intron|PIAS3_uc001eod.1_Missense_Mutation_p.I48V	NM_006099	NP_006090	Q9Y6X2	PIAS3_HUMAN	protein inhibitor of activated STAT, 3	379	SP-RING-type.				positive regulation of protein sumoylation|protein sumoylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck	enzyme binding|nucleic acid binding|protein C-terminus binding|zinc ion binding			ovary(1)	1	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TGAATCTCTTATCATTGATGG	0.388		NA											14	89					0	0	0	0
THEM5	284486	broad.mit.edu	37	1	151824868	151824868	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr1:151824868G>A	uc009wnd.2	-	2	323	c.191C>T	c.(190-192)TCG>TTG	p.S64L		NM_182578	NP_872384	Q8N1Q8	THEM5_HUMAN	thioesterase superfamily member 5	64							hydrolase activity			ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			CAGCATGTCCGAACACCAGCT	0.493		NA											20	117					0	0	0	0
RPTN	126638	broad.mit.edu	37	1	152128610	152128610	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr1:152128610G>A	uc001ezs.1	-	3	1030	c.965C>T	c.(964-966)ACG>ATG	p.T322M		NM_001122965	NP_001116437	Q6XPR3	RPTN_HUMAN	repetin	322	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding				0						TTGTCTGTCCGTCTGACTGTA	0.498		NA											13	854					0	0	0	0
FCRL6	343413	broad.mit.edu	37	1	159785428	159785428	+	Missense_Mutation	SNP	G	G	A	rs146779081	byFrequency	TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr1:159785428G>A	uc001fud.3	+	10	1324	c.1282G>A	c.(1282-1284)GAC>AAC	p.D428N	FCRL6_uc001fuc.2_3'UTR|FCRL6_uc009wsz.1_3'UTR|FCRL6_uc009wta.2_3'UTR	NM_001004310	NP_001004310	Q6DN72	FCRL6_HUMAN	Fc receptor-like 6 precursor	428	Cytoplasmic (Potential).					integral to membrane				ovary(2)|skin(1)	3	all_hematologic(112;0.0597)					ACCCCTTAGCGACTGTGAGGA	0.547		NA											10	46					0	0	0	0
EPRS	2058	broad.mit.edu	37	1	220153465	220153465	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr1:220153465T>C	uc001hly.1	-	26	3943	c.3673A>G	c.(3673-3675)ATA>GTA	p.I1225V		NM_004446	NP_004437	P07814	SYEP_HUMAN	glutamyl-prolyl tRNA synthetase	1225	Prolyl-tRNA synthetase.				glutamyl-tRNA aminoacylation|prolyl-tRNA aminoacylation|protein complex assembly	cytosol|soluble fraction	ATP binding|glutamate-tRNA ligase activity|proline-tRNA ligase activity|protein binding|RNA binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(131;0.0735)	L-Glutamic Acid(DB00142)|L-Proline(DB00172)	AATGCTTCTATTGTAGTTGTA	0.408		NA											11	118					0	0	0	0
PARP1	142	broad.mit.edu	37	1	226552719	226552719	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr1:226552719G>A	uc001hqd.3	-	19	2813	c.2642C>T	c.(2641-2643)CCG>CTG	p.P881L		NM_001618	NP_001609	P09874	PARP1_HUMAN	poly (ADP-ribose) polymerase family, member 1	881	PARP catalytic.				cellular response to insulin stimulus|protein ADP-ribosylation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nuclear envelope|nucleolus|transcription factor complex	DNA binding|identical protein binding|NAD+ ADP-ribosyltransferase activity|protein N-terminus binding|transcription factor binding|zinc ion binding			lung(3)|ovary(2)|breast(2)|skin(2)|upper_aerodigestive_tract(1)	10	Breast(184;0.133)			GBM - Glioblastoma multiforme(131;0.0531)		CGCTTCAGGCGGGGCTATCCG	0.567		NA						Direct_reversal_of_damage|PARP_enzymes_that_bind_to_DNA					4	90					0	0	0	0
SNAP47	116841	broad.mit.edu	37	1	227935683	227935683	+	Silent	SNP	C	C	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr1:227935683C>T	uc001hrf.2	+	2	795	c.381C>T	c.(379-381)TCC>TCT	p.S127S	SNAP47_uc001hqz.2_Silent_p.S82S|SNAP47_uc001hra.2_Intron|SNAP47_uc001hrd.2_Silent_p.S127S|SNAP47_uc001hre.2_Intron|SNAP47_uc001hrg.1_Silent_p.S82S	NM_053052	NP_444280	Q5SQN1	SNP47_HUMAN	synaptosomal-associated protein, 47kDa	127						endomembrane system|membrane|perinuclear region of cytoplasm				ovary(1)	1						GGTTCAGCTCCCTGCGGCCAA	0.547		NA											8	90					0	0	0	0
GNPAT	8443	broad.mit.edu	37	1	231396372	231396372	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr1:231396372C>A	uc001hup.3	+	3	587	c.381C>A	c.(379-381)AGC>AGA	p.S127R	GNPAT_uc009xfo.1_Missense_Mutation_p.S18R|GNPAT_uc009xfp.2_Missense_Mutation_p.S66R	NM_014236	NP_055051	O15228	GNPAT_HUMAN	glyceronephosphate O-acyltransferase	127					ether lipid biosynthetic process|fatty acid metabolic process|organ morphogenesis	peroxisomal matrix|peroxisomal membrane	glycerone-phosphate O-acyltransferase activity			ovary(3)|breast(1)	4	Breast(184;0.0871)	all_cancers(173;0.2)|Prostate(94;0.183)				TCACCCTGAGCAAAGTATTTA	0.363		NA											29	233					2.85e-18	5.15e-18	1	0
RYR2	6262	broad.mit.edu	37	1	237659856	237659856	+	Silent	SNP	G	G	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr1:237659856G>A	uc001hyl.1	+	20	2127	c.2007G>A	c.(2005-2007)CAG>CAA	p.Q669Q		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	669	Cytoplasmic (By similarity).|B30.2/SPRY 1.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GTTCTGCTCAGTATAAGAAAT	0.448		NA											13	59					0	0	0	0
AKT3	10000	broad.mit.edu	37	1	243708856	243708856	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr1:243708856T>C	uc001iab.1	-	11	1288	c.1207A>G	c.(1207-1209)AGT>GGT	p.S403G	AKT3_uc001hzz.1_Missense_Mutation_p.S403G	NM_005465	NP_005456	Q9Y243	AKT3_HUMAN	AKT3 kinase isoform 1	403	Protein kinase.				signal transduction	Golgi apparatus|nucleus|plasma membrane	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(1)|lung(1)|breast(1)|central_nervous_system(1)	4	all_cancers(71;0.000307)|all_epithelial(71;0.000374)|all_lung(81;0.0323)|Ovarian(71;0.0619)|all_neural(11;0.101)|Lung NSC(105;0.168)	all_cancers(173;0.0274)	all cancers(7;4.3e-08)|GBM - Glioblastoma multiforme(7;5.12e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00196)			GAGAAGAAACTGTGTCTCATA	0.328		NA											8	54					0	0	0	0
OR2L3	391192	broad.mit.edu	37	1	248223987	248223987	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr1:248223987G>T	uc001idx.1	+	1	4	c.4G>T	c.(4-6)GAA>TAA	p.E2*	OR2L13_uc001ids.2_Intron	NM_001004687	NP_001004687	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L,	2	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			ATGCCCCATGGAAAATTACAA	0.303		NA											30	119					5.77e-19	1.05e-18	1	0
OR2L3	391192	broad.mit.edu	37	1	248224181	248224181	+	Silent	SNP	C	C	G			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr1:248224181C>G	uc001idx.1	+	1	198	c.198C>G	c.(196-198)TCC>TCG	p.S66S	OR2L13_uc001ids.2_Intron	NM_001004687	NP_001004687	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L,	66	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			GTCAGCTCTCCCTCATTGACC	0.423		NA											39	326					0	0	0	0
ADARB2	105	broad.mit.edu	37	10	1405839	1405839	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr10:1405839G>T	uc009xhq.2	-	3	835	c.461C>A	c.(460-462)CCG>CAG	p.P154Q		NM_018702	NP_061172	Q9NS39	RED2_HUMAN	adenosine deaminase, RNA-specific, B2	154	DRBM 1.				mRNA processing	mitochondrion|nucleus	adenosine deaminase activity|double-stranded RNA binding|metal ion binding|single-stranded RNA binding			large_intestine(2)|central_nervous_system(1)	3		all_epithelial(10;0.059)|Colorectal(49;0.0815)		all cancers(11;0.0224)|GBM - Glioblastoma multiforme(2;0.0414)|Epithelial(11;0.165)		CGCGAAGACCGGGGCATGCAC	0.692		NA											3	28					0.00024832	0.000390122	1	0
ACBD5	91452	broad.mit.edu	37	10	27493384	27493384	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr10:27493384T>C	uc010qdp.1	-	12	1741	c.1550A>G	c.(1549-1551)TAT>TGT	p.Y517C	ACBD5_uc010qdm.1_Missense_Mutation_p.Y515C|ACBD5_uc010qdn.1_Missense_Mutation_p.Y408C|ACBD5_uc010qdo.1_Missense_Mutation_p.Y340C|ACBD5_uc001ito.2_Missense_Mutation_p.Y482C|ACBD5_uc001itp.2_Missense_Mutation_p.Y408C|ACBD5_uc001itq.2_Missense_Mutation_p.Y408C|ACBD5_uc001itr.1_Missense_Mutation_p.Y306C	NM_145698	NP_663736	Q5T8D3	ACBD5_HUMAN	acyl-Coenzyme A binding domain containing 5	526	Helical; (Potential).				transport	integral to membrane|peroxisomal membrane	fatty-acyl-CoA binding				0						CCTTCTTTGATAGTATAAATA	0.413		NA											6	32					0	0	0	0
ASAH2	56624	broad.mit.edu	37	10	52005019	52005019	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr10:52005019C>T	uc001jjd.2	-	2	323	c.323G>A	c.(322-324)CGA>CAA	p.R108Q	ASAH2_uc009xos.2_Missense_Mutation_p.R108Q	NM_019893	NP_063946	Q9NR71	ASAH2_HUMAN	N-acylsphingosine amidohydrolase 2 isoform a	108	Lumenal (Potential).				apoptosis|ceramide metabolic process|signal transduction	integral to membrane|mitochondrion|plasma membrane	ceramidase activity				0						GCAGTCAGCTCGTCCAACACC	0.448		NA											34	210					0	0	0	0
UNC5B	219699	broad.mit.edu	37	10	73057778	73057778	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr10:73057778A>G	uc001jro.2	+	16	3048	c.2603A>G	c.(2602-2604)AAC>AGC	p.N868S	UNC5B_uc001jrp.2_Missense_Mutation_p.N857S|UNC5B_uc001jrq.1_5'Flank	NM_170744	NP_734465	Q8IZJ1	UNC5B_HUMAN	unc-5 homolog B precursor	868	Cytoplasmic (Potential).|Death.				apoptosis|axon guidance|regulation of apoptosis	integral to membrane				ovary(2)|lung(1)	3						AAGATATGCAACAGCCTAGAT	0.572		NA											8	55					0	0	0	0
MKI67	4288	broad.mit.edu	37	10	129913914	129913914	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr10:129913914T>G	uc001lke.2	-	7	953	c.758A>C	c.(757-759)CAA>CCA	p.Q253P	MKI67_uc001lkf.2_Intron|MKI67_uc009yav.1_Intron|MKI67_uc009yaw.1_Intron	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	253					cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				ATTTTCTTTTTGTGATTTTAC	0.373		NA											4	55					0	0	0	0
MGMT	4255	broad.mit.edu	37	10	131565165	131565165	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr10:131565165G>T	uc001lkh.2	+	5	647	c.621G>T	c.(619-621)TTG>TTT	p.L207F		NM_002412	NP_002403	P16455	MGMT_HUMAN	O-6-methylguanine-DNA methyltransferase	176										ovary(1)|breast(1)	2		all_cancers(35;9.44e-09)|all_epithelial(44;6.98e-08)|Lung NSC(174;0.0157)|all_lung(145;0.0201)|all_neural(114;0.0732)|Colorectal(57;0.0792)|Breast(234;0.167)		OV - Ovarian serous cystadenocarcinoma(35;0.00291)		GCCACCGGTTGGGGAAGCCAG	0.662		NA						Direct_reversal_of_damage					8	25					1.07e-07	1.8e-07	1	0
LRRC56	115399	broad.mit.edu	37	11	554064	554064	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr11:554064C>A	uc010qvz.1	+	14	1922	c.1417C>A	c.(1417-1419)CAG>AAG	p.Q473K		NM_198075	NP_932341	Q8IYG6	LRC56_HUMAN	leucine rich repeat containing 56	473										skin(1)	1		all_cancers(49;2.16e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GACAGACCTGCAGTCCAGGGG	0.701		NA											17	96					9.17e-09	1.55e-08	1	0
OR51V1	283111	broad.mit.edu	37	11	5221490	5221490	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr11:5221490A>C	uc010qyz.1	-	1	441	c.441T>G	c.(439-441)AAT>AAG	p.N147K		NM_001004760	NP_001004760	Q9H2C8	O51V1_HUMAN	olfactory receptor, family 51, subfamily V,	147	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.83e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TAATTCTGGAATTAGTCAGGA	0.398		NA											6	47					0	0	0	0
ANO3	63982	broad.mit.edu	37	11	26529781	26529781	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr11:26529781G>A	uc001mqt.3	+	5	708	c.563G>A	c.(562-564)AGA>AAA	p.R188K	ANO3_uc010rdr.1_Missense_Mutation_p.R172K|ANO3_uc010rds.1_Missense_Mutation_p.R42K|ANO3_uc010rdt.1_Missense_Mutation_p.R42K	NM_031418	NP_113606	Q9BYT9	ANO3_HUMAN	transmembrane protein 16C	188	Cytoplasmic (Potential).					chloride channel complex	chloride channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						AAGAACCTCAGAGCAGAAGGC	0.318		NA											7	43					0	0	0	0
OR5M11	219487	broad.mit.edu	37	11	56310671	56310671	+	Silent	SNP	C	C	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr11:56310671C>T	uc010rjl.1	-	1	63	c.63G>A	c.(61-63)CCG>CCA	p.P21P		NM_001005245	NP_001005245	Q96RB7	OR5MB_HUMAN	olfactory receptor, family 5, subfamily M,	21	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						ACTGGAGTTCCGGGCAATCTG	0.458		NA											10	110					0	0	0	0
TNKS1BP1	85456	broad.mit.edu	37	11	57085295	57085295	+	Silent	SNP	A	A	G			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr11:57085295A>G	uc001njr.2	-	3	1107	c.795T>C	c.(793-795)GCT>GCC	p.A265A	TNKS1BP1_uc001njs.2_Silent_p.A265A|TNKS1BP1_uc009ymd.1_5'UTR	NM_033396	NP_203754	Q9C0C2	TB182_HUMAN	tankyrase 1-binding protein 1	265	Pro-rich.|Acidic.				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			skin(1)	1		all_epithelial(135;0.21)				AACTCACATCAGCAGGTAGCT	0.358		NA											8	23					0	0	0	0
CTNND1	1500	broad.mit.edu	37	11	57582974	57582974	+	Splice_Site	SNP	T	T	C			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr11:57582974T>C	uc001nmc.3	+	19	3379	c.2808_splice	c.e19+2	p.M936_splice	CTNND1_uc001nlh.1_Splice_Site_p.M936_splice|CTNND1_uc001nlu.3_Splice_Site_p.M829_splice|CTNND1_uc001nlt.3_Splice_Site_p.M829_splice|CTNND1_uc001nls.3_Splice_Site_p.M808_splice|CTNND1_uc001nlw.3_Splice_Site_p.M829_splice|CTNND1_uc001nmf.3_Splice_Site_p.M936_splice|CTNND1_uc001nmd.3_Splice_Site_p.M882_splice|CTNND1_uc001nlk.3_Splice_Site_p.M882_splice|CTNND1_uc001nme.3_Splice_Site_p.M930_splice|CTNND1_uc001nll.3_Splice_Site_p.M876_splice|CTNND1_uc001nmg.3_Splice_Site_p.M876_splice|CTNND1_uc001nlj.3_Splice_Site_p.M876_splice|CTNND1_uc001nlr.3_Splice_Site_p.M876_splice|CTNND1_uc001nlp.3_Splice_Site_p.M855_splice|CTNND1_uc001nlx.3_Splice_Site_p.M613_splice|CTNND1_uc001nlz.3_Splice_Site_p.M613_splice|CTNND1_uc009ymn.2_Splice_Site_p.M607_splice|CTNND1_uc001nlm.3_Splice_Site_p.M930_splice|CTNND1_uc001nly.3_Splice_Site_p.M607_splice|CTNND1_uc001nmb.3_Splice_Site_p.M607_splice|CTNND1_uc001nma.3_Splice_Site_p.M586_splice|CTNND1_uc001nmi.3_Splice_Site_p.M835_splice|CTNND1_uc001nmh.3_Splice_Site_p.M930_splice|CTNND1_uc001nlq.3_Splice_Site_p.M835_splice|CTNND1_uc001nln.3_Splice_Site_p.M930_splice|CTNND1_uc001nli.3_Splice_Site_p.M909_splice|CTNND1_uc001nlo.3_Splice_Site_p.M829_splice|CTNND1_uc001nlv.3_Splice_Site_p.M829_splice	NM_001085458	NP_001078927	O60716	CTND1_HUMAN	catenin, delta 1 isoform 1ABC						adherens junction organization|cell junction assembly|negative regulation of canonical Wnt receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	cytosol|midbody|nucleus	cadherin binding|protein binding|receptor binding			breast(4)|ovary(1)|kidney(1)	6		all_epithelial(135;0.155)				CCCTTGATGGTAAATTCTCTT	0.413		NA											3	20					0	0	0	0
NUMA1	4926	broad.mit.edu	37	11	71729904	71729904	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr11:71729904T>A	uc001orl.1	-	10	879	c.707A>T	c.(706-708)GAG>GTG	p.E236V	NUMA1_uc009ysw.1_5'Flank|NUMA1_uc001ork.1_Missense_Mutation_p.E236V|NUMA1_uc001orm.1_Missense_Mutation_p.E236V|NUMA1_uc001orn.2_5'Flank|NUMA1_uc009ysx.1_Missense_Mutation_p.E236V|NUMA1_uc001oro.1_Missense_Mutation_p.E236V|NUMA1_uc009ysy.1_Missense_Mutation_p.E236V|NUMA1_uc001orp.2_Missense_Mutation_p.E236V|NUMA1_uc001orq.2_Missense_Mutation_p.E236V	NM_006185	NP_006176	Q14980	NUMA1_HUMAN	nuclear mitotic apparatus protein 1	236	Potential.				G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			ovary(3)|lung(2)|skin(2)|central_nervous_system(1)	8						CTCAGCTAGCTCCAGCTCCAG	0.562		NA	T	RARA	APL								22	110					0	0	0	0
RELT	84957	broad.mit.edu	37	11	73106507	73106507	+	Missense_Mutation	SNP	C	C	T	rs139368769	byFrequency	TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr11:73106507C>T	uc001otv.2	+	11	1429	c.1264C>T	c.(1264-1266)CGG>TGG	p.R422W	RELT_uc001otw.2_Missense_Mutation_p.R422W|RELT_uc001otx.2_RNA	NM_152222	NP_689408	Q969Z4	TR19L_HUMAN	RELT tumor necrosis factor receptor precursor	422	Cytoplasmic (Potential).					cytoplasm|integral to membrane|plasma membrane	binding|receptor activity			upper_aerodigestive_tract(1)	1						ctatgtggtccggctaagtga	0.129		NA											17	82					0	0	0	0
PIWIL4	143689	broad.mit.edu	37	11	94341767	94341767	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr11:94341767G>A	uc001pfa.2	+	15	2069	c.1858G>A	c.(1858-1860)GTC>ATC	p.V620I	PIWIL4_uc010rue.1_Intron|PIWIL4_uc009ywk.1_RNA	NM_152431	NP_689644	Q7Z3Z4	PIWL4_HUMAN	piwi-like 4	620	Piwi.				cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|meiosis|multicellular organismal development|piRNA metabolic process|regulation of translation|spermatogenesis	nucleus|piP-body	piRNA binding			skin(1)	1		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				CCTGATGGTGGTCGGTATTGA	0.388		NA											33	102					0	0	0	0
OR6X1	390260	broad.mit.edu	37	11	123624803	123624803	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr11:123624803G>T	uc010rzy.1	-	1	424	c.424C>A	c.(424-426)CTG>ATG	p.L142M		NM_001005188	NP_001005188	Q8NH79	OR6X1_HUMAN	olfactory receptor, family 6, subfamily X,	142	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		CTCAGGGCCAGCTGCAGGCAG	0.507		NA											12	74					6.82e-15	1.2e-14	1	0
ANO2	57101	broad.mit.edu	37	12	5685021	5685021	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr12:5685021T>C	uc001qnm.2	-	24	2672	c.2600A>G	c.(2599-2601)GAC>GGC	p.D867G		NM_020373	NP_065106	Q9NQ90	ANO2_HUMAN	anoctamin 2	872	Extracellular (Potential).					chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			ovary(4)|large_intestine(2)|central_nervous_system(1)	7						AACCTCCTGGTCAAACTGTGA	0.493		NA											5	40					0	0	0	0
ATN1	1822	broad.mit.edu	37	12	7048173	7048173	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr12:7048173C>A	uc001qrw.1	+	7	3284	c.3047C>A	c.(3046-3048)TCC>TAC	p.S1016Y	ATN1_uc001qrx.1_Missense_Mutation_p.S1016Y	NM_001007026	NP_001007027	P54259	ATN1_HUMAN	atrophin-1	1016					cell death|central nervous system development	cytoplasm|nucleus	protein domain specific binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6						CCTGACATGTCCTATGCTGAG	0.667		NA											23	78					7.93e-12	1.37e-11	1	0
CD69	969	broad.mit.edu	37	12	9907188	9907188	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr12:9907188G>T	uc001qwk.2	-	4	567	c.486C>A	c.(484-486)AAC>AAA	p.N162K	CD69_uc010sgu.1_Missense_Mutation_p.N162K|CD69_uc010sgv.1_3'UTR	NM_001781	NP_001772	Q07108	CD69_HUMAN	CD69 molecule	162	C-type lectin.|Extracellular (Potential).					integral to plasma membrane	sugar binding|transmembrane receptor activity				0						CTTACCAGTTGTTAAATTCTT	0.413		NA											38	123					9.81e-26	1.8e-25	1	0
CAPRIN2	65981	broad.mit.edu	37	12	30877333	30877333	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr12:30877333G>T	uc001rji.1	-	10	2709	c.1958C>A	c.(1957-1959)CCG>CAG	p.P653Q	CAPRIN2_uc001rjf.1_Missense_Mutation_p.P450Q|CAPRIN2_uc001rjg.1_Missense_Mutation_p.P320Q|CAPRIN2_uc001rjh.1_Missense_Mutation_p.P653Q|CAPRIN2_uc001rjj.1_Missense_Mutation_p.P320Q|CAPRIN2_uc001rjk.3_Missense_Mutation_p.P653Q|CAPRIN2_uc001rjl.3_Missense_Mutation_p.P653Q|CAPRIN2_uc001rjm.1_Missense_Mutation_p.P320Q	NM_001002259	NP_001002259	Q6IMN6	CAPR2_HUMAN	C1q domain containing 1 isoform 1	653					negative regulation of cell growth|negative regulation of translation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of transcription from RNA polymerase II promoter	mitochondrion|receptor complex	receptor binding|RNA binding			ovary(1)|central_nervous_system(1)	2	all_lung(12;1.13e-09)|Lung NSC(12;7.98e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					AGCTGAAGGCGGTTGTGACGT	0.388		NA											4	26					0.000602214	0.000936068	1	0
ADAMTS20	80070	broad.mit.edu	37	12	43822059	43822059	+	Silent	SNP	G	G	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr12:43822059G>A	uc010skx.1	-	26	3930	c.3930C>T	c.(3928-3930)ACC>ACT	p.T1310T	ADAMTS20_uc001rno.1_Silent_p.T428T|ADAMTS20_uc001rnp.1_Silent_p.T464T	NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	1310	TSP type-1 9.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		CCCATGGTCCGGTTCTCCACT	0.358		NA											10	92					0	0	0	0
ITGB7	3695	broad.mit.edu	37	12	53590515	53590515	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr12:53590515G>A	uc009zmv.2	-	5	735	c.664C>T	c.(664-666)CGC>TGC	p.R222C	ITGB7_uc001scc.2_Missense_Mutation_p.R222C|ITGB7_uc010snz.1_RNA|ITGB7_uc010soa.1_3'UTR	NM_000889	NP_000880	P26010	ITB7_HUMAN	integrin, beta 7 precursor	222	VWFA.|Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|multicellular organismal development|regulation of immune response	integrin complex	identical protein binding|metal ion binding|receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|breast(1)	8						GACTGGCAGCGCTCCAGCCGG	0.617		NA											8	15					0	0	0	0
ESYT1	23344	broad.mit.edu	37	12	56528126	56528126	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr12:56528126G>A	uc001sjq.2	+	15	1596	c.1546G>A	c.(1546-1548)GCT>ACT	p.A516T	ESYT1_uc001sjr.2_Missense_Mutation_p.A526T	NM_015292	NP_056107	Q9BSJ8	ESYT1_HUMAN	extended synaptotagmin-like protein 1	516	C2 2.					integral to membrane		p.A516G(1)		ovary(4)|skin(1)	5						ACATCTCCAGGCTGTCTACAG	0.502		NA											35	104					0	0	0	0
LRP1	4035	broad.mit.edu	37	12	57604546	57604546	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr12:57604546G>A	uc001snd.2	+	83	13266	c.12800G>A	c.(12799-12801)TGC>TAC	p.C4267Y		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	4267	EGF-like 18.|Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	GGCCCCAAATGCACCCAGCAG	0.667		NA											14	90					0	0	0	0
TMBIM4	51643	broad.mit.edu	37	12	66531827	66531827	+	Silent	SNP	G	G	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr12:66531827G>A	uc001stc.2	-	7	706	c.630C>T	c.(628-630)TAC>TAT	p.Y210Y	LLPH_uc010ssx.1_RNA|TMBIM4_uc001std.2_Silent_p.Y179Y|TMBIM4_uc009zqr.2_Silent_p.Y257Y|TMBIM4_uc001ste.2_RNA|TMBIM4_uc001stf.2_3'UTR|TMBIM4_uc009zqs.2_3'UTR	NM_016056	NP_057140	Q9HC24	TMBI4_HUMAN	transmembrane BAX inhibitor motif containing 4	210	Helical; (Potential).					integral to membrane	protein binding			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(28;0.0745)		CAGCTAATACGTACTCTTCAG	0.413		NA											25	47					0	0	0	0
C12orf63	374467	broad.mit.edu	37	12	97043804	97043804	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr12:97043804T>C	uc001tet.1	+	2	179	c.101T>C	c.(100-102)GTA>GCA	p.V34A		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	34										skin(6)|ovary(1)	7						AATTTGTGTGTAATGGATCAT	0.308		NA											10	52					0	0	0	0
ACAD10	80724	broad.mit.edu	37	12	112150407	112150407	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr12:112150407C>T	uc001tsq.2	+	6	996	c.796C>T	c.(796-798)CCG>TCG	p.P266S	ACAD10_uc001tso.3_Missense_Mutation_p.P266S|ACAD10_uc001tsp.2_Missense_Mutation_p.P266S|ACAD10_uc009zvx.2_Missense_Mutation_p.P297S|ACAD10_uc001tsr.2_Missense_Mutation_p.P4S|ACAD10_uc001tss.1_5'Flank	NM_025247	NP_079523	Q6JQN1	ACD10_HUMAN	acyl-Coenzyme A dehydrogenase family, member 10	266							acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|hydrolase activity|transferase activity, transferring phosphorus-containing groups			ovary(2)	2						GATGGAAATTCCGAAAGATTC	0.453		NA											30	197					0	0	0	0
VSIG10	54621	broad.mit.edu	37	12	118517157	118517157	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr12:118517157G>T	uc001tws.2	-	4	1253	c.919C>A	c.(919-921)CAG>AAG	p.Q307K		NM_019086	NP_061959	Q8N0Z9	VSI10_HUMAN	V-set and immunoglobulin domain containing 10	307	Ig-like C2-type 3.|Extracellular (Potential).					integral to membrane					0						TCACTGATCTGCACCATGCAG	0.517		NA											6	64					2.01e-06	3.33e-06	1	0
DHX37	57647	broad.mit.edu	37	12	125470690	125470690	+	Silent	SNP	C	C	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr12:125470690C>T	uc001ugy.2	-	2	327	c.228G>A	c.(226-228)GAG>GAA	p.E76E		NM_032656	NP_116045	Q8IY37	DHX37_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 37	76							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;8.05e-05)|Epithelial(86;0.000486)|all cancers(50;0.00653)		GCACTTTCTTCTCCTTCTTGG	0.512		NA											77	114					0	0	0	0
CDK8	1024	broad.mit.edu	37	13	26971342	26971342	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr13:26971342G>A	uc001uqr.1	+	9	939	c.913G>A	c.(913-915)GAT>AAT	p.D305N	CDK8_uc001uqs.1_Missense_Mutation_p.D305N|CDK8_uc001uqt.1_Missense_Mutation_p.D132N	NM_001260	NP_001251	P49336	CDK8_HUMAN	cyclin-dependent kinase 8	305	Protein kinase.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mediator complex	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(2)|large_intestine(1)|ovary(1)|skin(1)	5	Colorectal(5;0.000442)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0384)|Epithelial(112;0.142)|OV - Ovarian serous cystadenocarcinoma(117;0.188)		AGTTAAACCAGATAGTAAAGC	0.318		NA											10	32					0	0	0	0
DGKH	160851	broad.mit.edu	37	13	42803280	42803280	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr13:42803280G>A	uc001uyl.1	+	30	3640	c.3619G>A	c.(3619-3621)GGA>AGA	p.G1207R	DGKH_uc010tfh.1_Missense_Mutation_p.G1163E|DGKH_uc001uym.1_Missense_Mutation_p.G1163E|DGKH_uc010tfi.1_Missense_Mutation_p.G918E|DGKH_uc010tfj.1_Missense_Mutation_p.G1062R|DGKH_uc001uyn.1_RNA|DGKH_uc001uyo.1_Missense_Mutation_p.G1078R|DGKH_uc001uyp.2_RNA	NM_178009	NP_821077	Q86XP1	DGKH_HUMAN	diacylglycerol kinase, eta isoform 2	1207	SAM.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation|protein oligomerization	endosome|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(2)	2		Lung NSC(96;1.02e-05)|Prostate(109;0.0168)|Lung SC(185;0.0262)|Breast(139;0.0709)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;5.88e-05)|GBM - Glioblastoma multiforme(144;0.000935)|BRCA - Breast invasive adenocarcinoma(63;0.109)		AATTCTCCAGGGAATTAAAGA	0.323		NA											14	82					0	0	0	0
CLN5	1203	broad.mit.edu	37	13	77566263	77566263	+	Silent	SNP	C	C	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr13:77566263C>T	uc001vkc.2	+	1	205	c.177C>T	c.(175-177)GGC>GGT	p.G59G		NM_006493	NP_006484	O75503	CLN5_HUMAN	ceroid-lipofuscinosis, neuronal 5	10					brain development|cell death|lysosomal lumen acidification|neuron maturation|protein catabolic process	endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosomal membrane|perinuclear region of cytoplasm	protein binding			ovary(1)	1		Acute lymphoblastic leukemia(28;0.205)		GBM - Glioblastoma multiforme(99;0.0503)		CGGCACAGGGCGCCGAGATgc	0.642		NA											7	23					0	0	0	0
EDNRB	1910	broad.mit.edu	37	13	78477688	78477688	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr13:78477688T>C	uc001vko.2	-	2	796	c.538A>G	c.(538-540)ATA>GTA	p.I180V	EDNRB_uc001vkq.1_Missense_Mutation_p.I180V|uc001vkn.1_Intron|EDNRB_uc010aez.1_Missense_Mutation_p.I180V|EDNRB_uc001vkp.1_Missense_Mutation_p.I263V	NM_001122659	NP_001116131	P24530	EDNRB_HUMAN	endothelin receptor type B isoform 1 precursor	180	Helical; Name=3; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|enteric nervous system development|enteric smooth muscle cell differentiation|macrophage chemotaxis|negative regulation of adenylate cyclase activity|negative regulation of cellular protein metabolic process|negative regulation of neuron maturation|negative regulation of transcription from RNA polymerase II promoter|vein smooth muscle contraction	integral to plasma membrane	endothelin-B receptor activity|peptide hormone binding				0		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0933)	Bosentan(DB00559)	GCTTTCTGTATGAAAGGCACC	0.443		NA											33	53					0	0	0	0
SLITRK1	114798	broad.mit.edu	37	13	84453689	84453689	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr13:84453689G>A	uc001vlk.2	-	1	2840	c.1954C>T	c.(1954-1956)CGA>TGA	p.R652*		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	652	Cytoplasmic (Potential).					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		TTGGCATCTCGTCTCTTGGAC	0.572		NA											13	47					0	0	0	0
ERCC5	2073	broad.mit.edu	37	13	103518238	103518238	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr13:103518238C>T	uc001vpw.2	+	9	2619	c.2176C>T	c.(2176-2178)CAT>TAT	p.H726Y	ERCC5_uc001vpu.1_Missense_Mutation_p.H1180Y|ERCC5_uc010tjb.1_Missense_Mutation_p.H726Y|ERCC5_uc010tjc.1_RNA|ERCC5_uc010tjd.1_Missense_Mutation_p.H558Y	NM_000123	NP_000114	P28715	ERCC5_HUMAN	XPG-complementing protein	726					negative regulation of apoptosis|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|response to UV-C|transcription-coupled nucleotide-excision repair|UV protection	nucleoplasm	bubble DNA binding|double-stranded DNA binding|endodeoxyribonuclease activity|metal ion binding|protein homodimerization activity|protein N-terminus binding|single-stranded DNA binding			ovary(4)|lung(1)|central_nervous_system(1)|skin(1)	7	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					AGATTCGCTCCATGAATGGCA	0.483		NA	Mis|N|F			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				9	48					0	0	0	0
FAM155A	728215	broad.mit.edu	37	13	108518140	108518140	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr13:108518140G>T	uc001vql.2	-	1	1321	c.805C>A	c.(805-807)CAG>AAG	p.Q269K		NM_001080396	NP_001073865	B1AL88	F155A_HUMAN	family with sequence similarity 155, member A	269						integral to membrane	binding			skin(1)	1						TCATAGTCCTGGTAAGCCTCG	0.522		NA											22	119					2.52e-20	4.59e-20	1	0
CMA1	1215	broad.mit.edu	37	14	24974805	24974805	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr14:24974805G>A	uc001wpp.1	-	5	691	c.661C>T	c.(661-663)CGG>TGG	p.R221W	CMA1_uc010alx.1_Missense_Mutation_p.R110W	NM_001836	NP_001827	P23946	CMA1_HUMAN	chymase 1, mast cell preproprotein	221	Peptidase S1.				interleukin-1 beta biosynthetic process|proteolysis	extracellular region	serine-type endopeptidase activity				0				GBM - Glioblastoma multiforme(265;0.0271)		GCATCCGACCGTCCATAGGAT	0.592		NA											9	62					0	0	0	0
KCNH5	27133	broad.mit.edu	37	14	63269189	63269189	+	Silent	SNP	G	G	T	rs114074278	byFrequency	TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr14:63269189G>T	uc001xfx.2	-	9	1731	c.1680C>A	c.(1678-1680)CGC>CGA	p.R560R	KCNH5_uc001xfy.2_Silent_p.R560R|KCNH5_uc001xfz.1_Silent_p.R502R	NM_139318	NP_647479	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H,	560	cNMP.|Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			ovary(4)|skin(4)|central_nervous_system(1)	9				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		CCGCCAAGGCGCGCAGACACC	0.507		NA											11	89					1.59e-06	2.64e-06	1	0
SYNE2	23224	broad.mit.edu	37	14	64496701	64496701	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr14:64496701T>C	uc001xgm.2	+	44	7033	c.6803T>C	c.(6802-6804)TTC>TCC	p.F2268S	SYNE2_uc001xgl.2_Missense_Mutation_p.F2268S	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	2268	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TTGGACAATTTCTCCAAGGAA	0.408		NA											3	35					0	0	0	0
TLN2	83660	broad.mit.edu	37	15	62939593	62939593	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr15:62939593C>G	uc002alb.3	+	1	84	c.84C>G	c.(82-84)TAC>TAG	p.Y28*	MGC15885_uc010uib.1_5'Flank|MGC15885_uc002ala.3_5'Flank	NM_015059	NP_055874	Q9Y4G6	TLN2_HUMAN	talin 2	28					cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			ovary(5)|upper_aerodigestive_tract(2)|lung(2)|breast(2)	11						CAGCTGTGTACGATGCGTGTC	0.488		NA											19	119					0	0	0	0
SOLH	6650	broad.mit.edu	37	16	596993	596993	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr16:596993G>A	uc002chi.2	+	4	518	c.155G>A	c.(154-156)CGC>CAC	p.R52H	SOLH_uc002chh.1_Missense_Mutation_p.R52H	NM_005632	NP_005623	O75808	CAN15_HUMAN	small optic lobes	52	RanBP2-type 2.				proteolysis	intracellular	calcium-dependent cysteine-type endopeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|breast(1)	2		Hepatocellular(780;0.00335)				CCCTGCGCCCGCTGCACCTTC	0.692		NA											5	40					0	0	0	0
ATP6V0C	527	broad.mit.edu	37	16	2569563	2569563	+	Silent	SNP	C	C	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr16:2569563C>T	uc002cqn.2	+	3	437	c.285C>T	c.(283-285)GCC>GCT	p.A95A	TBC1D24_uc002cqm.2_3'UTR|ATP6V0C_uc002cqo.2_Silent_p.A52A|AMDHD2_uc002cqp.2_5'Flank|AMDHD2_uc002cqq.2_5'Flank|AMDHD2_uc010uwc.1_5'Flank|AMDHD2_uc010uwd.1_5'Flank	NM_001694	NP_001685	P27449	VATL_HUMAN	ATPase, H+ transporting, lysosomal, V0 subunit	95	Helical; (Potential).				ATP hydrolysis coupled proton transport|ATP synthesis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|interspecies interaction between organisms|transferrin transport	endosome membrane|integral to membrane|proton-transporting ATP synthase complex, coupling factor F(o)|proton-transporting V-type ATPase, V0 domain|vacuolar membrane	hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism|ubiquitin protein ligase binding			ovary(1)	1		Ovarian(90;0.17)				AGCTGGGCGCCGGCCTGAGCG	0.701		NA											19	39					0	0	0	0
TXNDC11	51061	broad.mit.edu	37	16	11792153	11792153	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr16:11792153G>A	uc010buu.1	-	8	1078	c.1016C>T	c.(1015-1017)ACA>ATA	p.T339I	TXNDC11_uc002dbg.1_Missense_Mutation_p.T312I	NM_015914	NP_056998	Q6PKC3	TXD11_HUMAN	thioredoxin domain containing 11	339					cell redox homeostasis	endoplasmic reticulum membrane|integral to membrane					0						GTTCTCAGCTGTGTAGTTCAG	0.552		NA											12	34					0	0	0	0
PDXDC1	23042	broad.mit.edu	37	16	15127244	15127244	+	Silent	SNP	G	G	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr16:15127244G>A	uc002dda.3	+	19	2024	c.1800G>A	c.(1798-1800)GAG>GAA	p.E600E	PDXDC1_uc010uzl.1_Silent_p.E585E|PDXDC1_uc010uzm.1_Silent_p.E509E|PDXDC1_uc002ddb.3_Silent_p.E573E|PDXDC1_uc010uzn.1_Silent_p.E572E|PDXDC1_uc002ddc.2_Intron	NM_015027	NP_055842	Q6P996	PDXD1_HUMAN	pyridoxal-dependent decarboxylase domain	600					carboxylic acid metabolic process		carboxy-lyase activity|protein binding|pyridoxal phosphate binding			skin(1)	1					Pyridoxal Phosphate(DB00114)	GGGAGATAGAGGAGAACTCGA	0.567		NA											33	101					0	0	0	0
ACSM2A	123876	broad.mit.edu	37	16	20486734	20486734	+	Silent	SNP	C	C	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr16:20486734C>T	uc010bwe.2	+	8	1184	c.945C>T	c.(943-945)TAC>TAT	p.Y315Y	ACSM2A_uc010bwd.1_RNA|ACSM2A_uc010vax.1_Silent_p.Y236Y|ACSM2A_uc002dhf.3_Silent_p.Y315Y|ACSM2A_uc002dhg.3_Silent_p.Y315Y|ACSM2A_uc010vay.1_Silent_p.Y236Y|ACSM2A_uc002dhh.3_5'Flank	NM_001010845	NP_001010845	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member	315					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			skin(2)|breast(1)	3						CCATTGTTTACCGGATGTTGC	0.512		NA											26	104					0	0	0	0
GTF3C1	2975	broad.mit.edu	37	16	27549582	27549582	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr16:27549582A>T	uc002dov.1	-	3	567	c.527T>A	c.(526-528)TTC>TAC	p.F176Y	GTF3C1_uc002dou.2_Missense_Mutation_p.F176Y	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	176						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						GCAGTAGGAGAAGTCGGGCAG	0.602		NA											16	93					0	0	0	0
DOC2A	8448	broad.mit.edu	37	16	30018259	30018259	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr16:30018259G>A	uc002dvm.2	-	8	825	c.725C>T	c.(724-726)GCG>GTG	p.A242V	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|DOC2A_uc002dvl.2_Missense_Mutation_p.A240V|DOC2A_uc002dvn.2_Missense_Mutation_p.A242V|DOC2A_uc010vef.1_RNA|DOC2A_uc002dvo.2_Missense_Mutation_p.A242V|DOC2A_uc002dvp.2_Missense_Mutation_p.A242V|DOC2A_uc002dvq.2_Missense_Mutation_p.A242V	NM_003586	NP_003577	Q14183	DOC2A_HUMAN	double C2-like domains, alpha	242	Interaction with UNC13D.				nervous system development|regulation of calcium ion-dependent exocytosis	cell junction|lysosome|synaptic vesicle membrane|synaptosome	calcium-dependent phospholipid binding|protein binding|transporter activity			ovary(2)	2						CCCCTGCTCCGCCTGCTCCAA	0.682		NA											8	22					0	0	0	0
SETD1A	9739	broad.mit.edu	37	16	30995053	30995053	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr16:30995053A>C	uc002ead.1	+	18	5596	c.4910A>C	c.(4909-4911)AAG>ACG	p.K1637T	HSD3B7_uc002eaf.2_5'Flank|HSD3B7_uc010cac.2_5'Flank|HSD3B7_uc002eag.2_5'Flank|HSD3B7_uc002eah.2_5'Flank	NM_014712	NP_055527	O15047	SET1A_HUMAN	SET domain containing 1A	1637	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			ovary(2)|skin(1)	3						GATGCCACCAAGTGTGGCAAC	0.652		NA											10	37					0	0	0	0
N4BP1	9683	broad.mit.edu	37	16	48580115	48580115	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr16:48580115G>T	uc002efp.2	-	6	2513	c.2276C>A	c.(2275-2277)CCT>CAT	p.P759H		NM_153029	NP_694574	O75113	N4BP1_HUMAN	Nedd4 binding protein 1	759					negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination	nucleolus|PML body					0		all_cancers(37;0.179)|all_lung(18;0.11)				TCTTCCCAGAGGATCATCGGG	0.458		NA											20	75					2.89e-11	4.95e-11	1	0
SETD6	79918	broad.mit.edu	37	16	58552440	58552440	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr16:58552440C>T	uc002ens.2	+	7	1168	c.1109C>T	c.(1108-1110)ACA>ATA	p.T370I	SETD6_uc002enr.2_Missense_Mutation_p.T346I|SETD6_uc010cdm.2_RNA	NM_001160305	NP_001153777	Q8TBK2	SETD6_HUMAN	SET domain containing 6 isoform a	370					negative regulation of NF-kappaB transcription factor activity|peptidyl-lysine monomethylation|regulation of inflammatory response	nucleus	NF-kappaB binding|protein-lysine N-methyltransferase activity			ovary(1)	1						CTGACCACCACACTAAAGGTA	0.443		NA											8	55					0	0	0	0
CNTROB	116840	broad.mit.edu	37	17	7847811	7847811	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr17:7847811C>T	uc002gjq.2	+	13	2508	c.1589C>T	c.(1588-1590)GCG>GTG	p.A530V	CNTROB_uc002gjp.2_Missense_Mutation_p.A530V|CNTROB_uc002gjr.2_Missense_Mutation_p.A432V|CNTROB_uc010vum.1_3'UTR	NM_053051	NP_444279	Q8N137	CNTRB_HUMAN	centrobin, centrosomal BRCA2 interacting protein	530	Potential.|Required for centrosome localization.				centriole replication|centrosome separation|cytokinesis	centriole	protein domain specific binding			breast(1)|central_nervous_system(1)	2		Prostate(122;0.173)				CGGGAGCAAGCGCGAGTGTGC	0.567		NA											5	30					0	0	0	0
ACCN1	40	broad.mit.edu	37	17	32483155	32483155	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr17:32483155C>T	uc002hhu.2	-	1	671	c.397G>A	c.(397-399)GTG>ATG	p.V133M		NM_001094	NP_001085	Q16515	ACCN1_HUMAN	amiloride-sensitive cation channel 1, neuronal	133	Extracellular (By similarity).				central nervous system development|peripheral nervous system development|synaptic transmission	integral to plasma membrane	ligand-gated sodium channel activity|protein binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Breast(31;0.042)|Ovarian(249;0.202)		UCEC - Uterine corpus endometrioid carcinoma (308;0.13)|BRCA - Breast invasive adenocarcinoma(366;0.215)	Amiloride(DB00594)	GCCTCCAGCACGGAGGGGTCA	0.612		NA											14	97					0	0	0	0
VAT1	10493	broad.mit.edu	37	17	41168533	41168533	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr17:41168533T>C	uc002icm.1	-	5	1009	c.889A>G	c.(889-891)AAC>GAC	p.N297D	VAT1_uc010cyw.1_Missense_Mutation_p.N163D|VAT1_uc010whk.1_Missense_Mutation_p.N229D	NM_006373	NP_006364	Q99536	VAT1_HUMAN	vesicle amine transport protein 1	297						cytoplasm|integral to membrane	oxidoreductase activity|zinc ion binding				0		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.156)		GCCATCAGGTTCCGTTTGGGG	0.612		NA											3	25					0	0	0	0
NSF	4905	broad.mit.edu	37	17	44770322	44770322	+	Silent	SNP	C	C	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr17:44770322C>T	uc002iku.2	+	10	1103	c.999C>T	c.(997-999)ATC>ATT	p.I333I	NSF_uc010wke.1_Silent_p.I239I|NSF_uc010wkf.1_Silent_p.I239I|NSF_uc010wkg.1_Silent_p.I328I	NM_006178	NP_006169	P46459	NSF_HUMAN	vesicle-fusing ATPase	333					protein transport|synaptic transmission	cytosol	ATP binding|metal ion binding			ovary(1)	1		Melanoma(429;0.203)	BRCA - Breast invasive adenocarcinoma(9;0.0257)	BRCA - Breast invasive adenocarcinoma(366;0.241)		TTGATGCCATCTGCAAGCAGA	0.418		NA											4	28					0	0	0	0
COL1A1	1277	broad.mit.edu	37	17	48263006	48263006	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr17:48263006G>A	uc002iqm.2	-	51	4378	c.4252C>T	c.(4252-4254)CAC>TAC	p.H1418Y		NM_000088	NP_000079	P02452	CO1A1_HUMAN	alpha 1 type I collagen preproprotein	1418	Fibrillar collagen NC1.				axon guidance|blood vessel development|collagen biosynthetic process|collagen fibril organization|embryonic skeletal system development|leukocyte migration|platelet activation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|protein localization to nucleus|sensory perception of sound|skin morphogenesis|tooth mineralization|visual perception	collagen type I|extracellular space|plasma membrane	identical protein binding|platelet-derived growth factor binding		COL1A1/PDGFB(372)	soft_tissue(372)|central_nervous_system(7)|skin(1)|breast(1)|pancreas(1)	382					Collagenase(DB00048)|Palifermin(DB00039)	GCTCCGGTGTGACTCTGGGGT	0.617		NA	T	PDGFB|USP6	dermatofibrosarcoma protuberans|aneurysmal bone cyst 		Osteogenesis imperfecta						8	40					0	0	0	0
RPS6KB1	6198	broad.mit.edu	37	17	58009058	58009058	+	Silent	SNP	G	G	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr17:58009058G>A	uc002ixy.2	+	7	766	c.663G>A	c.(661-663)CCG>CCA	p.P221P	RPS6KB1_uc010ddj.1_Silent_p.P221P|RPS6KB1_uc010wom.1_Silent_p.P168P|RPS6KB1_uc010won.1_Silent_p.P198P|RPS6KB1_uc010woo.1_Silent_p.P156P	NM_003161	NP_003152	P23443	KS6B1_HUMAN	ribosomal protein S6 kinase, 70kDa, polypeptide	221	Protein kinase.				apoptosis|G1/S transition of mitotic cell cycle|insulin receptor signaling pathway|negative regulation of apoptosis|phosphatidylinositol-mediated signaling|positive regulation of mitotic cell cycle|positive regulation of translational initiation|TOR signaling cascade	cell junction|cytoplasm|cytosol|mitochondrial outer membrane|nucleus|nucleus|synapse|synaptosome	ATP binding|protein binding|protein kinase activity			large_intestine(1)	1	all_cancers(5;1.63e-13)|Breast(5;2.91e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;3.57e-12)|all cancers(12;6.41e-11)			ACCTGAAGCCGGAGAATATCA	0.388		NA											7	38					0	0	0	0
SMURF2	64750	broad.mit.edu	37	17	62589665	62589665	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr17:62589665G>A	uc002jep.1	-	4	615	c.227C>T	c.(226-228)ACG>ATG	p.T76M	SMURF2_uc002jeq.1_Translation_Start_Site|SMURF2_uc002jer.1_Translation_Start_Site	NM_022739	NP_073576	Q9HAU4	SMUF2_HUMAN	SMAD specific E3 ubiquitin protein ligase 2	76	C2.				BMP signaling pathway|negative regulation of transcription, DNA-dependent|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent SMAD protein catabolic process	cytosol|membrane raft|nucleus|plasma membrane|ubiquitin ligase complex	identical protein binding|SMAD binding|ubiquitin-protein ligase activity			skin(3)|lung(1)	4	Breast(5;1.32e-14)		BRCA - Breast invasive adenocarcinoma(8;9.88e-12)			TACACTGATCGTAACTGAATC	0.393		NA											6	64					0	0	0	0
ARSG	22901	broad.mit.edu	37	17	66381312	66381312	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr17:66381312A>T	uc002jhc.2	+	9	1886	c.1090A>T	c.(1090-1092)AGC>TGC	p.S364C	ARSG_uc002jhb.1_Missense_Mutation_p.S200C	NM_014960	NP_055775	Q96EG1	ARSG_HUMAN	Arylsulfatase G precursor	364					sulfur compound metabolic process	endoplasmic reticulum|extracellular space|lysosome	arylsulfatase activity|metal ion binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(8;5.34e-07)|LUSC - Lung squamous cell carcinoma(166;0.24)			TGCCTTGTTAAGGTATGAGAC	0.418		NA											24	49					0	0	0	0
SYT4	6860	broad.mit.edu	37	18	40854093	40854093	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr18:40854093G>T	uc002law.2	-	2	670	c.301C>A	c.(301-303)CTC>ATC	p.L101I	SYT4_uc010dng.2_Intron|SYT4_uc010xcm.1_Missense_Mutation_p.L83I|SYT4_uc010dnh.2_Intron	NM_020783	NP_065834	Q9H2B2	SYT4_HUMAN	synaptotagmin IV	101	Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			skin(5)	5						TTGCCATTGAGATCTCTCTTT	0.398		NA											12	90					1.36e-13	2.38e-13	1	0
ST8SIA5	29906	broad.mit.edu	37	18	44260231	44260231	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr18:44260231C>T	uc002lcj.1	-	7	1473	c.905G>A	c.(904-906)GGC>GAC	p.G302D	ST8SIA5_uc002lci.1_Missense_Mutation_p.G149D|ST8SIA5_uc010xcy.1_Missense_Mutation_p.G338D|ST8SIA5_uc010xcz.1_Missense_Mutation_p.G271D	NM_013305	NP_037437	O15466	SIA8E_HUMAN	ST8 alpha-N-acetyl-neuraminide	302	Lumenal (Potential).				glycosphingolipid biosynthetic process|protein glycosylation	integral to Golgi membrane				upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	3						CAGAATGAGGCCGGTGCTGAT	0.622		NA											15	75					0	0	0	0
CDH7	1005	broad.mit.edu	37	18	63511243	63511243	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr18:63511243G>A	uc002ljz.2	+	7	1502	c.1177G>A	c.(1177-1179)GGG>AGG	p.G393R	CDH7_uc002lka.2_Missense_Mutation_p.G393R|CDH7_uc002lkb.2_Missense_Mutation_p.G393R	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	393	Extracellular (Potential).|Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				TACCCAGGTTGGGAATATCAT	0.448		NA											41	75					0	0	0	0
TSHZ1	10194	broad.mit.edu	37	18	72999914	72999914	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr18:72999914T>A	uc002lly.2	+	2	2980	c.2417T>A	c.(2416-2418)CTG>CAG	p.L806Q		NM_005786	NP_005777	Q6ZSZ6	TSH1_HUMAN	teashirt family zinc finger 1	851						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Esophageal squamous(42;0.129)|Prostate(75;0.142)|Melanoma(33;0.211)		Colorectal(1;0.000501)|READ - Rectum adenocarcinoma(2;0.00226)|BRCA - Breast invasive adenocarcinoma(31;0.246)		ACAGGCCGCCTGACGCCCAAG	0.602		NA											9	79					0	0	0	0
SALL3	27164	broad.mit.edu	37	18	76757094	76757094	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr18:76757094G>A	uc002lmt.2	+	3	3675	c.3675G>A	c.(3673-3675)ATG>ATA	p.M1225I	SALL3_uc010dra.2_Missense_Mutation_p.M760I	NM_171999	NP_741996	Q9BXA9	SALL3_HUMAN	sal-like 3	1225					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		GGCTCGCCATGAAGAACAACG	0.602		NA											35	166					0	0	0	0
C3	718	broad.mit.edu	37	19	6714452	6714452	+	Silent	SNP	C	C	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr19:6714452C>T	uc002mfm.2	-	5	572	c.510G>A	c.(508-510)CCG>CCA	p.P170P		NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor	170					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		GGATGCCTTCCGGGTTCTGTG	0.562		NA											5	43					0	0	0	0
PDE4A	5141	broad.mit.edu	37	19	10570295	10570295	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr19:10570295C>T	uc002moj.2	+	10	1333	c.1225C>T	c.(1225-1227)CGC>TGC	p.R409C	PDE4A_uc002mok.2_Missense_Mutation_p.R383C|PDE4A_uc002mol.2_Missense_Mutation_p.R348C|PDE4A_uc002mom.2_Missense_Mutation_p.R170C|PDE4A_uc002mon.2_Intron|PDE4A_uc002moo.2_Missense_Mutation_p.R75C	NM_001111307	NP_001104777	P27815	PDE4A_HUMAN	phosphodiesterase 4A isoform 1	409	Catalytic.				signal transduction	cytosol|membrane fraction|perinuclear region of cytoplasm|ruffle membrane|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3			OV - Ovarian serous cystadenocarcinoma(20;5.8e-10)|Epithelial(33;7.58e-07)|all cancers(31;3.91e-06)		Cilostazol(DB01166)|Dipyridamole(DB00975)|Dyphylline(DB00651)|Enprofylline(DB00824)|Iloprost(DB01088)|Milrinone(DB00235)|Pentoxifylline(DB00806)|Phentolamine(DB00692)|Tadalafil(DB00820)|Theophylline(DB00277)	GAAGAAATTCCGCATCCCTGT	0.637		NA											6	39					0	0	0	0
SMARCA4	6597	broad.mit.edu	37	19	11101902	11101902	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr19:11101902G>A	uc002mqf.3	+	8	1606	c.1322G>A	c.(1321-1323)CGC>CAC	p.R441H	SMARCA4_uc010dxp.2_Missense_Mutation_p.R441H|SMARCA4_uc010dxo.2_Missense_Mutation_p.R441H|SMARCA4_uc002mqg.1_Missense_Mutation_p.R441H|SMARCA4_uc010dxq.2_Missense_Mutation_p.R441H|SMARCA4_uc010dxr.2_Missense_Mutation_p.R441H|SMARCA4_uc002mqj.3_Missense_Mutation_p.R441H|SMARCA4_uc010dxs.2_Missense_Mutation_p.R441H|SMARCA4_uc002mqe.2_Missense_Mutation_p.R441H	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	441					chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				GCCTACAAGCGCAGCAAGCGC	0.632		NA	F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				4	38					0	0	0	0
ZNF625	90589	broad.mit.edu	37	19	12256889	12256889	+	Silent	SNP	C	C	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr19:12256889C>T	uc002mth.2	-	4	494	c.144G>A	c.(142-144)AGG>AGA	p.R48R	ZNF20_uc002mtg.1_Intron|ZNF625_uc010dyn.1_RNA|ZNF625_uc010dyo.1_Silent_p.R82R	NM_145233	NP_660276	Q96I27	ZN625_HUMAN	zinc finger protein 625	48	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CTCTGTGGTGCCTATTAAGGG	0.443		NA											17	56					0	0	0	0
ZNF99	7652	broad.mit.edu	37	19	22940808	22940808	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr19:22940808T>C	uc010xrh.1	-	5	1630	c.1630A>G	c.(1630-1632)ACC>GCC	p.T544A		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TTTCTAAGGGTTGAGGACTGG	0.373		NA											12	61					0	0	0	0
ACTN4	81	broad.mit.edu	37	19	39191741	39191741	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr19:39191741T>A	uc002oja.1	+	3	436	c.377T>A	c.(376-378)CTG>CAG	p.L126Q	ACTN4_uc010egc.1_Missense_Mutation_p.L126Q	NM_004924	NP_004915	O43707	ACTN4_HUMAN	actinin, alpha 4	126	Actin-binding.|CH 1.				platelet activation|platelet degranulation|positive regulation of cellular component movement|positive regulation of sodium:hydrogen antiporter activity|protein transport|regulation of apoptosis	extracellular region|nucleolus|perinuclear region of cytoplasm|platelet alpha granule lumen|protein complex|pseudopodium|ribonucleoprotein complex	actin filament binding|calcium ion binding|integrin binding|nucleoside binding|protein homodimerization activity				0	all_cancers(60;1.57e-05)|Ovarian(47;0.103)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			GGCGTCAAGCTGGTCTCCATC	0.557		NA											21	51					0	0	0	0
CEACAM3	1084	broad.mit.edu	37	19	42314017	42314017	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr19:42314017G>A	uc002orn.1	+	4	633	c.557G>A	c.(556-558)CGT>CAT	p.R186H	CEACAM3_uc010eia.1_Intron|CEACAM3_uc002oro.1_RNA	NM_001815	NP_001806	P40198	CEAM3_HUMAN	carcinoembryonic antigen-related cell adhesion	186	Cytoplasmic (Potential).					integral to membrane				skin(1)	1						AGCATCCAGCGTGACCTCAAG	0.592		NA											36	295					0	0	0	0
IRF2BP1	26145	broad.mit.edu	37	19	46388533	46388533	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr19:46388533A>T	uc002pds.1	-	1	844	c.500T>A	c.(499-501)CTG>CAG	p.L167Q		NM_015649	NP_056464	Q8IU81	I2BP1_HUMAN	interferon regulatory factor 2 binding protein	167					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00442)|GBM - Glioblastoma multiforme(486;0.0402)|Epithelial(262;0.231)		TGCAGCTGCCAGCAGCCCAGG	0.682		NA											9	61					0	0	0	0
TSKS	60385	broad.mit.edu	37	19	50250010	50250010	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr19:50250010G>A	uc002ppm.2	-	6	720	c.709C>T	c.(709-711)CGA>TGA	p.R237*		NM_021733	NP_068379	Q9UJT2	TSKS_HUMAN	testis-specific kinase substrate	237							protein binding			large_intestine(1)|skin(1)	2		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		tcctgccgtcgcggcgtctca	0.284		NA											6	34					0	0	0	0
MYADM	91663	broad.mit.edu	37	19	54377153	54377153	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr19:54377153T>C	uc002qcl.2	+	3	518	c.370T>C	c.(370-372)TAT>CAT	p.Y124H	MYADM_uc002qcm.2_Missense_Mutation_p.Y124H|MYADM_uc002qcn.2_Missense_Mutation_p.Y124H|MYADM_uc002qco.2_Missense_Mutation_p.Y124H|MYADM_uc002qcp.2_Missense_Mutation_p.Y124H	NM_001020820	NP_001018656	Q96S97	MYADM_HUMAN	myeloid-associated differentiation marker	124	MARVEL 1.					integral to membrane				ovary(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.0488)		CCCCACCACCTATGTCCAGTT	0.647		NA											20	129					0	0	0	0
NLRP2	55655	broad.mit.edu	37	19	55481573	55481573	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr19:55481573G>C	uc002qij.2	+	2	276	c.190G>C	c.(190-192)GAC>CAC	p.D64H	NLRP2_uc010yfp.1_Intron|NLRP2_uc010esn.2_Missense_Mutation_p.D64H|NLRP2_uc010eso.2_Missense_Mutation_p.D64H|NLRP2_uc010esp.2_Missense_Mutation_p.D64H	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	64	DAPIN.				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		CACCCATTGTGACAGCTACTG	0.532		NA											15	74					0	0	0	0
NLRP2	55655	broad.mit.edu	37	19	55494909	55494909	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr19:55494909G>T	uc002qij.2	+	6	1929	c.1843G>T	c.(1843-1845)GAG>TAG	p.E615*	NLRP2_uc010yfp.1_Nonsense_Mutation_p.E592*|NLRP2_uc010esn.2_Nonsense_Mutation_p.E591*|NLRP2_uc010eso.2_Nonsense_Mutation_p.E612*|NLRP2_uc010esp.2_Nonsense_Mutation_p.E593*	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	615					apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		GTCTCAGGAGGAGGAGCTGGT	0.507		NA											12	30					5.51e-06	9.02e-06	1	0
SBK2	646643	broad.mit.edu	37	19	56047567	56047567	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr19:56047567A>T	uc010ygc.1	-	1	95	c.95T>A	c.(94-96)CTC>CAC	p.L32H		NM_001101401	NP_001094871	P0C263	SBK2_HUMAN	SH3-binding domain kinase family, member 2	32							ATP binding|protein serine/threonine kinase activity				0						GCCCTGCTGGAGCTCCTCTAA	0.667		NA											4	38					0	0	0	0
ZNF581	51545	broad.mit.edu	37	19	56156365	56156365	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr19:56156365G>A	uc002qln.2	+	2	1144	c.428G>A	c.(427-429)CGG>CAG	p.R143Q	ZNF581_uc002qlq.2_Missense_Mutation_p.R143Q|CCDC106_uc002qlr.2_5'Flank	NM_016535	NP_057619	Q9P0T4	ZN581_HUMAN	zinc finger protein 581	143					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Ovarian(87;0.133)	BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.105)		GGTGGTGGGCGGCCCCACGGC	0.667		NA											21	104					0	0	0	0
NLRP4	147945	broad.mit.edu	37	19	56369225	56369225	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr19:56369225C>T	uc002qmd.3	+	3	888	c.466C>T	c.(466-468)CCA>TCA	p.P156S	NLRP4_uc002qmf.2_Missense_Mutation_p.P81S|NLRP4_uc010etf.2_5'UTR	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	156	NACHT.|ATP (Potential).						ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		CATTCAAGGACCACAAGGAAT	0.473		NA											18	151					0	0	0	0
MYT1L	23040	broad.mit.edu	37	2	1921066	1921066	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr2:1921066C>A	uc002qxe.2	-	11	2356	c.1529G>T	c.(1528-1530)GGG>GTG	p.G510V	MYT1L_uc002qxd.2_Missense_Mutation_p.G508V|MYT1L_uc010ewl.1_RNA	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	510	C2HC-type 2.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		TCCATCACACCCGGGGGTTGG	0.507		NA											54	104					1.86e-20	3.4e-20	1	0
APOB	338	broad.mit.edu	37	2	21239357	21239357	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr2:21239357T>C	uc002red.2	-	21	3414	c.3286A>G	c.(3286-3288)ATT>GTT	p.I1096V		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	1096					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TTGTTCTGAATGTCCAGGGTG	0.478		NA											6	46					0	0	0	0
ATAD2B	54454	broad.mit.edu	37	2	24011485	24011485	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr2:24011485C>A	uc002rek.3	-	20	2967	c.2673G>T	c.(2671-2673)GAG>GAT	p.E891D	ATAD2B_uc010yki.1_RNA|ATAD2B_uc002rei.3_Missense_Mutation_p.E136D|ATAD2B_uc002rej.3_Missense_Mutation_p.E59D	NM_017552	NP_060022	Q9ULI0	ATD2B_HUMAN	ATPase family, AAA domain containing 2B	891							ATP binding|nucleoside-triphosphatase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TATACAAGACCTCTTCATACT	0.313		NA											13	22					0.00136819	0.00211547	1	0
DQX1	165545	broad.mit.edu	37	2	74745638	74745638	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr2:74745638C>T	uc010yrw.1	-	12	2254	c.2089G>A	c.(2089-2091)GAT>AAT	p.D697N	DQX1_uc002smc.2_Missense_Mutation_p.D258N	NM_133637	NP_598376	Q8TE96	DQX1_HUMAN	DEAQ box polypeptide 1 (RNA-dependent ATPase)	697						nucleus	ATP binding|helicase activity|nucleic acid binding			ovary(2)	2						GCTGTAGAATCTGCCATTCCT	0.532		NA											9	51					0	0	0	0
GYPC	2995	broad.mit.edu	37	2	127451474	127451474	+	Silent	SNP	C	C	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr2:127451474C>A	uc002tnq.2	+	3	297	c.141C>A	c.(139-141)GGC>GGA	p.G47G	GYPC_uc002tnr.2_Silent_p.G28G|GYPC_uc010flv.2_RNA	NM_002101	NP_002092	P04921	GLPC_HUMAN	glycophorin C isoform 1	47	Extracellular.					cortical cytoskeleton|integral to plasma membrane	protein binding			central_nervous_system(1)	1	Colorectal(110;0.0533)			BRCA - Breast invasive adenocarcinoma(221;0.075)		GGCCGGATGGCAGAATGGAGA	0.562		NA											9	84					0.000274275	0.000428601	1	0
FMNL2	114793	broad.mit.edu	37	2	153504404	153504404	+	Silent	SNP	C	C	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr2:153504404C>T	uc002tye.2	+	26	3631	c.3264C>T	c.(3262-3264)GCC>GCT	p.A1088A	FMNL2_uc010fob.2_3'UTR|FMNL2_uc002tyf.2_3'UTR	NM_052905	NP_443137	Q96PY5	FMNL2_HUMAN	formin-like 2	Error:Variant_position_missing_in_Q96PY5_after_alignment					actin cytoskeleton organization	cytoplasm	actin binding|Rho GTPase binding			central_nervous_system(2)|ovary(1)	3						TTAATGGTGCCGAAATAACAA	0.478		NA											20	169					0	0	0	0
KLHL23	151230	broad.mit.edu	37	2	170592711	170592711	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr2:170592711G>T	uc002ufh.1	+	4	1525	c.1187G>T	c.(1186-1188)TGG>TTG	p.W396L	KLHL23_uc002ufi.1_Missense_Mutation_p.W396L	NM_144711	NP_653312	Q8NBE8	KLH23_HUMAN	kelch-like 23	396	Kelch 3.										0						AAAGAGAAATGGATTCCTATT	0.408		NA											12	104					7.04e-09	1.19e-08	1	0
DNAJC10	54431	broad.mit.edu	37	2	183627484	183627484	+	Silent	SNP	A	A	C			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr2:183627484A>C	uc002uow.1	+	22	2636	c.2221A>C	c.(2221-2223)AGG>CGG	p.R741R	DNAJC10_uc002uox.1_RNA|DNAJC10_uc002uoy.1_RNA|DNAJC10_uc002uoz.1_Silent_p.R695R|DNAJC10_uc010fro.1_RNA	NM_018981	NP_061854	Q8IXB1	DJC10_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 10	741	Thioredoxin 4.				apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|ER-associated protein catabolic process|glycerol ether metabolic process|negative regulation of protein phosphorylation|protein folding|response to endoplasmic reticulum stress	endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|extracellular region	ATPase activator activity|ATPase binding|chaperone binding|electron carrier activity|heat shock protein binding|misfolded protein binding|protein disulfide oxidoreductase activity|unfolded protein binding			ovary(1)|large_intestine(1)|breast(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			AGCTGGGATCAGGGCCTATCC	0.408		NA											4	49					0	0	0	0
ALS2	57679	broad.mit.edu	37	2	202593826	202593826	+	Silent	SNP	C	C	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr2:202593826C>T	uc002uyo.2	-	14	3017	c.2661G>A	c.(2659-2661)AAG>AAA	p.K887K	ALS2_uc002uyp.3_Silent_p.K887K|ALS2_uc010ftl.2_RNA	NM_020919	NP_065970	Q96Q42	ALS2_HUMAN	alsin isoform 1	887					cell death|endosome organization|positive regulation of Rac GTPase activity|regulation of endosome size	centrosome|cytosol|early endosome|growth cone|lamellipodium|protein complex|ruffle	protein homodimerization activity|protein serine/threonine kinase activator activity|Rab GTPase binding|Rab guanyl-nucleotide exchange factor activity|Rac guanyl-nucleotide exchange factor activity|Ran guanyl-nucleotide exchange factor activity			skin(5)|lung(1)|breast(1)	7						ATTCTGCTTCCTTCCTTTTCC	0.453		NA											129	78					0	0	0	0
CPS1	1373	broad.mit.edu	37	2	211502448	211502448	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr2:211502448C>G	uc002vee.3	+	22	2842	c.2710C>G	c.(2710-2712)CTG>GTG	p.L904V	CPS1_uc010fur.2_Missense_Mutation_p.L910V|CPS1_uc010fus.2_Missense_Mutation_p.L453V	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	904					carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		AGAAGAAACCCTGAAAAGGGC	0.398		NA											7	39					0	0	0	0
CHRND	1144	broad.mit.edu	37	2	233398936	233398936	+	Missense_Mutation	SNP	C	C	T	rs140455307		TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr2:233398936C>T	uc002vsw.2	+	11	1259	c.1255C>T	c.(1255-1257)CGG>TGG	p.R419W	CHRND_uc010zmg.1_Missense_Mutation_p.R404W|CHRND_uc010fyc.2_Missense_Mutation_p.R292W|CHRND_uc010zmh.1_Missense_Mutation_p.R225W	NM_000751	NP_000742	Q07001	ACHD_HUMAN	nicotinic acetylcholine receptor delta	419	Cytoplasmic (Potential).				muscle contraction|musculoskeletal movement|neuromuscular process|skeletal muscle tissue growth|synaptic transmission	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			ovary(1)|breast(1)|skin(1)	3		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.89e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00078)|Lung(119;0.00579)|LUSC - Lung squamous cell carcinoma(224;0.00754)		GTCTGTAGGCCGGCCCCCAGC	0.607		NA											12	71					0	0	0	0
GIGYF2	26058	broad.mit.edu	37	2	233680442	233680442	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr2:233680442G>T	uc002vti.3	+	21	2540	c.2203G>T	c.(2203-2205)GCA>TCA	p.A735S	GIGYF2_uc010zmj.1_Missense_Mutation_p.A735S|GIGYF2_uc002vtg.2_Missense_Mutation_p.A729S|GIGYF2_uc002vtj.3_Missense_Mutation_p.A756S|GIGYF2_uc002vtk.3_Missense_Mutation_p.A735S|GIGYF2_uc002vth.3_Missense_Mutation_p.A729S|GIGYF2_uc010zmk.1_RNA|GIGYF2_uc010zml.1_Missense_Mutation_p.A566S|GIGYF2_uc002vtq.3_Missense_Mutation_p.A68S	NM_015575	NP_056390	Q6Y7W6	PERQ2_HUMAN	GRB10 interacting GYF protein 2 isoform b	735	Gln-rich.				cell death		protein binding			ovary(4)|central_nervous_system(3)	7		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		GGCCAAAGCTGCAAAGGTCTG	0.478		NA											3	29					0.004672	0.0070744	1	0
HDAC4	9759	broad.mit.edu	37	2	240085518	240085518	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr2:240085518C>T	uc002vyk.3	-	6	1384	c.592G>A	c.(592-594)GAC>AAC	p.D198N	HDAC4_uc010fyz.1_Missense_Mutation_p.D193N|HDAC4_uc010zoa.1_Missense_Mutation_p.D193N|HDAC4_uc010fza.2_Missense_Mutation_p.D198N|HDAC4_uc010fyy.2_Missense_Mutation_p.D150N|HDAC4_uc010znz.1_Missense_Mutation_p.D81N	NM_006037	NP_006028	P56524	HDAC4_HUMAN	histone deacetylase 4	198	Interaction with MEF2A.				B cell differentiation|cardiac muscle hypertrophy in response to stress|chromatin remodeling|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of glycolysis|negative regulation of myotube differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development|peptidyl-lysine deacetylation|positive regulation of cell proliferation|positive regulation of protein sumoylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|response to denervation involved in regulation of muscle adaptation|response to interleukin-1|transcription, DNA-dependent	histone deacetylase complex|transcriptional repressor complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|potassium ion binding|repressing transcription factor binding|zinc ion binding			breast(3)|skin(2)|ovary(1)	6		all_epithelial(40;1.45e-17)|Breast(86;1.53e-05)|Renal(207;0.000355)|all_lung(227;0.0121)|Ovarian(221;0.0183)|Lung NSC(271;0.0413)|Melanoma(123;0.0749)|all_hematologic(139;0.159)		Epithelial(121;6.38e-25)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-12)|Kidney(56;6.04e-08)|KIRC - Kidney renal clear cell carcinoma(57;1.18e-06)|BRCA - Breast invasive adenocarcinoma(100;3.99e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.04)		TAGCGAGGGTCGCTGGAAATG	0.562		NA											22	78					0	0	0	0
SNRPB2	6629	broad.mit.edu	37	20	16721614	16721614	+	Silent	SNP	G	G	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr20:16721614G>A	uc002wph.1	+	7	858	c.642G>A	c.(640-642)CCG>CCA	p.P214P	SNRPB2_uc002wpi.1_Silent_p.P214P	NM_003092	NP_003083	P08579	RU2B_HUMAN	small nuclear ribonucleoprotein polypeptide B''	214	RRM 2.					catalytic step 2 spliceosome|nucleoplasm|U2 snRNP	nucleotide binding|protein binding|RNA binding			large_intestine(1)	1						AGATCACACCGTCCCATGCTA	0.413		NA											8	63					0	0	0	0
CHD6	84181	broad.mit.edu	37	20	40162087	40162087	+	Silent	SNP	A	A	G			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr20:40162087A>G	uc002xka.1	-	3	334	c.156T>C	c.(154-156)GCT>GCC	p.A52A	CHD6_uc002xkd.2_Silent_p.A30A|CHD6_uc002xkc.2_Silent_p.A87A	NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	52					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				GACAGTGACTAGCAACATCTT	0.448		NA											53	91					0	0	0	0
BMP7	655	broad.mit.edu	37	20	55803477	55803477	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr20:55803477A>G	uc010gip.1	-	2	948	c.419T>C	c.(418-420)GTG>GCG	p.V140A	BMP7_uc010giq.1_Missense_Mutation_p.V140A|BMP7_uc002xyc.2_Missense_Mutation_p.V140A	NM_001719	NP_001710	P18075	BMP7_HUMAN	bone morphogenetic protein 7 precursor	140					BMP signaling pathway|cartilage development|cellular response to hypoxia|epithelial to mesenchymal transition|growth|mesonephros development|negative regulation of glomerular mesangial cell proliferation|negative regulation of MAP kinase activity|negative regulation of mitosis|negative regulation of neuron differentiation|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of phosphorylation|negative regulation of striated muscle cell apoptosis|negative regulation of transcription, DNA-dependent|ossification|pathway-restricted SMAD protein phosphorylation|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|protein localization to nucleus|regulation of removal of superoxide radicals|SMAD protein signal transduction|steroid hormone mediated signaling pathway|ureteric bud development	extracellular space	cytokine activity|growth factor activity			skin(1)	1	all_lung(29;0.0133)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(4;2.49e-13)|Epithelial(14;1.74e-08)|all cancers(14;2.05e-07)			GTCATGTTCCACTGGAAGAGG	0.512		NA											3	114					0	0	0	0
LAMA5	3911	broad.mit.edu	37	20	60888727	60888727	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr20:60888727C>T	uc002ycq.2	-	63	8703	c.8636G>A	c.(8635-8637)GGG>GAG	p.G2879E		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	2879	Laminin G-like 1.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGGGTACCCCCCGACGTAGAA	0.677		NA											18	76					0	0	0	0
POTEH	23784	broad.mit.edu	37	22	16267041	16267042	+	Missense_Mutation	DNP	GG	GG	AT			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr22:16267041_16267042GG>AT	uc010gqp.2	-	9	1459_1460	c.1407_1408CC>AT	c.(1405-1410)AACCTG>AAATTG	p.N469K	POTEH_uc002zlg.1_RNA|POTEH_uc002zlh.1_Missense_Mutation_p.N188K|POTEH_uc002zlj.1_Missense_Mutation_p.N304K	NM_001136213	NP_001129685	Q6S545	POTEH_HUMAN	ANKRD26-like family C, member 3	469										skin(1)	1						CCGTTAGTCAGGTTTTCTGGGA	0.401		NA											25	573					0	0	0	0
CELSR1	9620	broad.mit.edu	37	22	46859980	46859980	+	Silent	SNP	G	G	A	rs148297929	byFrequency	TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr22:46859980G>A	uc003bhw.1	-	2	3807	c.3807C>T	c.(3805-3807)GGC>GGT	p.G1269G		NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	1269	Extracellular (Potential).				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		GGCCGCGGACGCCGCCAGGCA	0.632		NA											6	48					0	0	0	0
RAF1	5894	broad.mit.edu	37	3	12653459	12653459	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr3:12653459C>T	uc003bxf.3	-	3	725	c.310G>A	c.(310-312)GAA>AAA	p.E104K	RAF1_uc011aut.1_5'Flank|RAF1_uc011auu.1_Intron	NM_002880	NP_002871	P04049	RAF1_HUMAN	v-raf-1 murine leukemia viral oncogene homolog	104	RBD.				activation of MAPKK activity|apoptosis|axon guidance|cell proliferation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|negative regulation of apoptosis|negative regulation of cell proliferation|negative regulation of protein complex assembly|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of peptidyl-serine phosphorylation|Ras protein signal transduction|synaptic transmission	cytosol|mitochondrial outer membrane|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|receptor signaling protein activity		ESRP1/RAF1(4)|SRGAP3/RAF1(4)	central_nervous_system(4)|prostate(4)|lung(2)|upper_aerodigestive_tract(1)|stomach(1)|liver(1)|ovary(1)	14					Sorafenib(DB00398)	CCTTTGTGTTCGTGGAGAAGT	0.428		NA	T	SRGAP3	pilocytic astrocytoma				Noonan_syndrome				49	87					0	0	0	0
C3orf75	54859	broad.mit.edu	37	3	47552662	47552662	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr3:47552662G>T	uc003crk.2	-	2	228	c.109C>A	c.(109-111)CAC>AAC	p.H37N	C3orf75_uc003crj.2_5'UTR|C3orf75_uc011bba.1_Silent_p.T11T|C3orf75_uc003crl.1_Missense_Mutation_p.H37N	NM_001031703	NP_001026873	Q0PNE2	CC075_HUMAN	transmembrane protein 103	37											0						GAGAGAAAGTGGTGTACAAGG	0.403		NA											8	51					9.7e-10	1.65e-09	1	0
ATRIP	84126	broad.mit.edu	37	3	48491541	48491541	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr3:48491541G>T	uc003ctf.1	+	2	378	c.346G>T	c.(346-348)GTA>TTA	p.V116L	ATRIP_uc011bbj.1_5'UTR|ATRIP_uc003ctg.1_Missense_Mutation_p.V116L	NM_130384	NP_569055	Q8WXE1	ATRIP_HUMAN	ATR interacting protein isoform 1	116	Potential.				DNA damage checkpoint|DNA repair|DNA replication	nucleoplasm	protein binding|protein serine/threonine kinase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CGAATTAGAGGTACTTCAGGC	0.333		NA						Other_conserved_DNA_damage_response_genes					31	53					1.89e-17	3.39e-17	1	0
RNF123	63891	broad.mit.edu	37	3	49744294	49744294	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr3:49744294G>A	uc003cxh.2	+	26	2545	c.2459G>A	c.(2458-2460)CGC>CAC	p.R820H	RNF123_uc010hky.1_Missense_Mutation_p.R482H|RNF123_uc003cxi.2_RNA	NM_022064	NP_071347	Q5XPI4	RN123_HUMAN	ring finger protein 123	820						cytoplasm	ligase activity|protein binding|zinc ion binding			kidney(3)|ovary(1)|lung(1)|breast(1)|skin(1)	7				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|Kidney(197;0.00227)|KIRC - Kidney renal clear cell carcinoma(197;0.00255)		CACCTGAGCCGCCGTCTTGCC	0.567		NA											12	45					0	0	0	0
CBLB	868	broad.mit.edu	37	3	105421037	105421037	+	Silent	SNP	T	T	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr3:105421037T>A	uc003dwc.2	-	12	2182	c.1860A>T	c.(1858-1860)ACA>ACT	p.T620T	CBLB_uc011bhi.1_Silent_p.T642T|CBLB_uc003dwd.1_Silent_p.T620T|CBLB_uc003dwe.1_Silent_p.T620T	NM_170662	NP_733762	Q13191	CBLB_HUMAN	Cas-Br-M (murine) ecotropic retroviral	620	Pro-rich.				cell surface receptor linked signaling pathway|NLS-bearing substrate import into nucleus	cytoplasm|nucleus	calcium ion binding|ligase activity|signal transducer activity|zinc ion binding			lung(4)|ovary(3)|breast(1)|skin(1)	9						TTGAACTCGCTGTGATTCCAG	0.517		NA	Mis S		AML								20	100					0	0	0	0
CCDC54	84692	broad.mit.edu	37	3	107096565	107096565	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr3:107096565G>C	uc003dwi.1	+	1	378	c.131G>C	c.(130-132)GGA>GCA	p.G44A		NM_032600	NP_115989	Q8NEL0	CCD54_HUMAN	coiled-coil domain containing 54	44											0						GATTCAACTGGATATCCCACT	0.398		NA											16	94					0	0	0	0
LRRC58	116064	broad.mit.edu	37	3	120053967	120053967	+	Silent	SNP	G	G	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr3:120053967G>A	uc003edr.2	-	3	745	c.649C>T	c.(649-651)CTA>TTA	p.L217L		NM_001099678	NP_001093148	Q96CX6	LRC58_HUMAN	leucine rich repeat containing 58	217	LRR 8.										0				GBM - Glioblastoma multiforme(114;0.147)		TGAAGACTTAGGGAACGAAGT	0.348		NA											4	53					0	0	0	0
UROC1	131669	broad.mit.edu	37	3	126220060	126220060	+	Splice_Site	SNP	C	C	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr3:126220060C>T	uc003eiz.1	-	10	997	c.965_splice	c.e10+1	p.W322_splice	UROC1_uc010hsi.1_Splice_Site_p.W382_splice	NM_144639	NP_653240	Q96N76	HUTU_HUMAN	urocanase domain containing 1 isoform 1						histidine catabolic process	cytosol	urocanate hydratase activity			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.17)		CCCCCACTCACCAAAGAGCCA	0.562		NA											29	282					0	0	0	0
ASTE1	28990	broad.mit.edu	37	3	130742943	130742943	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr3:130742943C>A	uc003env.1	-	3	1650	c.1208G>T	c.(1207-1209)AGT>ATT	p.S403I	NEK11_uc003enx.2_5'Flank|NEK11_uc003eny.2_5'Flank|NEK11_uc003eoa.2_5'Flank|NEK11_uc003enz.2_5'Flank|NEK11_uc010htn.2_5'Flank|NEK11_uc011blk.1_5'Flank|NEK11_uc011bll.1_5'Flank|NEK11_uc003enw.1_5'Flank|NEK11_uc011blm.1_5'Flank|ASTE1_uc010htm.1_Missense_Mutation_p.S403I|ASTE1_uc011blj.1_RNA	NM_014065	NP_054784	Q2TB18	ASTE1_HUMAN	asteroid homolog 1	403					DNA repair		nuclease activity				0						TTCCACTTCACTGAAAGCTAG	0.428		NA											48	106					6.77e-33	1.24e-32	1	0
TMEM22	80723	broad.mit.edu	37	3	136574278	136574278	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr3:136574278G>A	uc003erf.3	+	2	1190	c.976G>A	c.(976-978)GTC>ATC	p.V326I	TMEM22_uc003erg.3_Missense_Mutation_p.V326I|TMEM22_uc010hub.2_Missense_Mutation_p.V326I	NM_001097600	NP_001091069	Q8TBE7	TMM22_HUMAN	transmembrane protein 22	326	DUF6 2.|Helical; (Potential).					Golgi apparatus|integral to membrane				ovary(1)	1						TGCTATATGTGTCTGTTCTAC	0.393		NA											75	189					0	0	0	0
TM4SF4	7104	broad.mit.edu	37	3	149216509	149216509	+	Silent	SNP	G	G	C			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr3:149216509G>C	uc003exd.1	+	4	633	c.402G>C	c.(400-402)GGG>GGC	p.G134G		NM_004617	NP_004608	P48230	T4S4_HUMAN	transmembrane 4 superfamily member 4	134	Extracellular (Potential).					integral to membrane					0			LUSC - Lung squamous cell carcinoma(72;0.0378)|Lung(72;0.048)			TCACCAACAGGGATTATCTCA	0.448		NA											4	35					0	0	0	0
PIK3CA	5290	broad.mit.edu	37	3	178952085	178952085	+	Missense_Mutation	SNP	A	A	G	rs121913279		TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr3:178952085A>G	uc003fjk.2	+	21	3297	c.3140A>G	c.(3139-3141)CAT>CGT	p.H1047R		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	1047	PI3K/PI4K.		H -> L (in cancer).|H -> R (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; requires binding to p85 regulatory subunit to induce cellular transformation but not interaction with RAS; may mimic the conformatitonal change triggered by the interaction with RAS; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells; increases lipid kinase activity; may alter the interaction of the PI3K/ PI4K kinase domain with the cell membrane).|H -> Y (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.H1047R(1269)|p.H1047L(152)|p.H1047Y(31)|p.H1047Q(3)|p.H1047T(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AATGATGCACATCATGGTGGC	0.378	H1047R(BT20_BREAST)|H1047R(NCIH1048_LUNG)|H1047R(MCAS_OVARY)|H1047R(HCC1954_BREAST)|H1047R(RKO_LARGE_INTESTINE)|H1047L(EFM19_BREAST)|H1047R(CAL33_UPPER_AERODIGESTIVE_TRACT)|H1047R(CAL29_URINARY_TRACT)|H1047R(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|H1047R(LS180_LARGE_INTESTINE)|H1047R(T47D_BREAST)|H1047R(HCT116_LARGE_INTESTINE)|H1047R(HSC2_UPPER_AERODIGESTIVE_TRACT)|H1047R(SKOV3_OVARY)|H1047R(MDAMB453_BREAST)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			6	43					0	0	0	0
FAM131A	131408	broad.mit.edu	37	3	184059698	184059698	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr3:184059698G>A	uc003fog.2	+	1	1441	c.77G>A	c.(76-78)GGG>GAG	p.G26E	FAM131A_uc003fob.1_Intron|FAM131A_uc003foc.2_Intron|FAM131A_uc003foe.2_Intron	NM_144635	NP_653236	Q6UXB0	F131A_HUMAN	hypothetical protein LOC131408 precursor	26						extracellular region				breast(1)	1	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TACATGCTGGGGTCTCCCCTT	0.547		NA											67	127					0	0	0	0
C3orf59	151963	broad.mit.edu	37	3	192516720	192516720	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr3:192516720G>C	uc011bsp.1	-	2	1252	c.931C>G	c.(931-933)CAG>GAG	p.Q311E		NM_178496	NP_848591	Q8IYB1	M21D2_HUMAN	hypothetical protein LOC151963	311											0	all_cancers(143;1.56e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.8e-18)|LUSC - Lung squamous cell carcinoma(58;8.04e-06)|Lung(62;8.62e-06)	GBM - Glioblastoma multiforme(46;3.86e-05)		TTGCAGGCCTGATAGGCCTGC	0.557		NA											9	40					0	0	0	0
WHSC1	7468	broad.mit.edu	37	4	1955057	1955057	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr4:1955057A>T	uc003gdz.3	+	12	2320	c.2144A>T	c.(2143-2145)CAC>CTC	p.H715L	WHSC1_uc003geb.3_Missense_Mutation_p.H715L|WHSC1_uc003gec.3_Missense_Mutation_p.H715L|WHSC1_uc003ged.3_Missense_Mutation_p.H715L|WHSC1_uc003gee.3_RNA|WHSC1_uc003gef.3_RNA|WHSC1_uc003gei.3_5'UTR|WHSC1_uc011bvh.1_5'UTR|WHSC1_uc010icf.2_Missense_Mutation_p.H63L	NM_001042424	NP_001035889	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1 protein	715	PHD-type 2.				anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		TTAGGGATTCACTCATGTTTC	0.403		NA	T	IGH@	MM								10	87					0	0	0	0
SCFD2	152579	broad.mit.edu	37	4	53751945	53751945	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr4:53751945T>C	uc003gzu.2	-	8	2065	c.1931A>G	c.(1930-1932)GAT>GGT	p.D644G	SCFD2_uc010igm.2_Missense_Mutation_p.D599G	NM_152540	NP_689753	Q8WU76	SCFD2_HUMAN	sec1 family domain containing 2	644					protein transport|vesicle docking involved in exocytosis					ovary(2)|pancreas(1)	3			GBM - Glioblastoma multiforme(3;1.07e-26)|LUSC - Lung squamous cell carcinoma(32;0.0134)			TGCCACAAGATCTTTGACCAT	0.532		NA											10	87					0	0	0	0
UGT2B4	7363	broad.mit.edu	37	4	70359477	70359477	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr4:70359477G>T	uc003hek.3	-	2	851	c.804C>A	c.(802-804)CAC>CAA	p.H268Q	UGT2B4_uc011cap.1_Missense_Mutation_p.H132Q|UGT2B4_uc003hel.3_Missense_Mutation_p.H268Q	NM_021139	NP_066962	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2B4 precursor	268					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(2)	2						GTAAGAGTGGGTGAGGAAATT	0.423		NA											40	88					4.33e-17	7.75e-17	1	0
SLC4A4	8671	broad.mit.edu	37	4	72423471	72423471	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr4:72423471C>T	uc003hfy.2	+	22	2923	c.2806C>T	c.(2806-2808)CAG>TAG	p.Q936*	SLC4A4_uc010iic.2_Nonsense_Mutation_p.Q936*|SLC4A4_uc010iib.2_Nonsense_Mutation_p.Q852*|SLC4A4_uc003hfz.2_Nonsense_Mutation_p.Q936*|SLC4A4_uc003hgc.3_Nonsense_Mutation_p.Q892*|SLC4A4_uc010iid.2_Nonsense_Mutation_p.Q140*	NM_001098484	NP_001091954	Q9Y6R1	S4A4_HUMAN	solute carrier family 4, sodium bicarbonate	936	Cytoplasmic (Potential).					basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|kidney(1)|skin(1)	5			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			TCTGAAGCATCAGCCTGACTT	0.507		NA											15	41					0	0	0	0
NPFFR2	10886	broad.mit.edu	37	4	73012719	73012719	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr4:73012719T>G	uc003hgg.2	+	4	857	c.759T>G	c.(757-759)TTT>TTG	p.F253L	NPFFR2_uc010iig.1_Missense_Mutation_p.F35L|NPFFR2_uc003hgi.2_Missense_Mutation_p.F154L|NPFFR2_uc003hgh.2_Missense_Mutation_p.F151L|NPFFR2_uc003hgj.2_RNA	NM_004885	NP_004876	Q9Y5X5	NPFF2_HUMAN	neuropeptide FF receptor 2 isoform 1	253	Cytoplasmic (Potential).				detection of abiotic stimulus	actin cytoskeleton|integral to plasma membrane	neuropeptide receptor activity			ovary(2)|central_nervous_system(1)	3			Lung(101;0.0935)|LUSC - Lung squamous cell carcinoma(112;0.138)			TCTACCCTTTTAAACCAAAGC	0.388		NA											13	169					0	0	0	0
FAM175A	84142	broad.mit.edu	37	4	84384670	84384670	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr4:84384670C>A	uc003hou.2	-	8	838	c.773G>T	c.(772-774)AGA>ATA	p.R258I	MRPS18C_uc011ccu.1_Intron|FAM175A_uc003hot.2_Missense_Mutation_p.R86I|FAM175A_uc003hov.2_Missense_Mutation_p.R149I	NM_139076	NP_620775	Q6UWZ7	F175A_HUMAN	coiled-coil domain containing 98	258	Potential.				chromatin modification|double-strand break repair|G2/M transition DNA damage checkpoint|positive regulation of DNA repair|response to ionizing radiation	BRCA1-A complex	polyubiquitin binding			kidney(1)	1						CTGTGCTCCTCTCCTTTTCTC	0.284		NA											10	66					7.48e-07	1.25e-06	1	0
MAPK10	5602	broad.mit.edu	37	4	86988972	86988972	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr4:86988972G>C	uc003hpq.2	-	9	1006	c.939C>G	c.(937-939)TTC>TTG	p.F313L	MAPK10_uc010ikg.2_Missense_Mutation_p.F275L|MAPK10_uc003hpr.2_Missense_Mutation_p.F275L|MAPK10_uc003hps.2_Missense_Mutation_p.F313L|MAPK10_uc003hpt.2_Missense_Mutation_p.F313L|MAPK10_uc003hpu.2_Missense_Mutation_p.F313L|MAPK10_uc003hpv.2_Missense_Mutation_p.F168L|MAPK10_uc003hpn.2_Missense_Mutation_p.F61L|MAPK10_uc003hpo.2_Missense_Mutation_p.F168L|MAPK10_uc011ccw.1_Missense_Mutation_p.F199L|MAPK10_uc003hpp.2_Missense_Mutation_p.F168L	NM_138982	NP_620448	P53779	MK10_HUMAN	mitogen-activated protein kinase 10 isoform 2	313	Protein kinase.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|JUN kinase activity|MAP kinase kinase activity|protein binding			stomach(1)|breast(1)|central_nervous_system(1)	3		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.243)		OV - Ovarian serous cystadenocarcinoma(123;0.002)		GGGAATCTGGGAAGAGTTTGG	0.488		NA											10	27					0	0	0	0
HERC6	55008	broad.mit.edu	37	4	89318075	89318075	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr4:89318075C>A	uc011cdi.1	+	7	1143	c.960C>A	c.(958-960)AGC>AGA	p.S320R	HERC6_uc003hrp.1_Intron|HERC6_uc011cdj.1_Missense_Mutation_p.S320R|HERC6_uc011cdk.1_RNA|HERC6_uc011cdl.1_Intron	NM_017912	NP_060382	Q8IVU3	HERC6_HUMAN	hect domain and RLD 6 isoform 1	320					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytosol	ubiquitin-protein ligase activity			lung(3)|ovary(1)|kidney(1)	5		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000222)		GTGACACAAGCAAGCCAACTC	0.453		NA											7	141					0.00307968	0.00471199	1	0
ADH4	127	broad.mit.edu	37	4	100062731	100062731	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr4:100062731C>T	uc003hun.2	-	3	299	c.223G>A	c.(223-225)GTG>ATG	p.V75M	uc003hum.1_Intron|ADH4_uc011ced.1_Missense_Mutation_p.V94M	NM_000670	NP_000661	P08319	ADH4_HUMAN	class II alcohol dehydrogenase, pi subunit	75					alcohol catabolic process|cellular aldehyde metabolic process|ethanol oxidation|quinone cofactor metabolic process|retinol metabolic process|xenobiotic metabolic process	cytosol|microtubule cytoskeleton	alcohol dehydrogenase activity, zinc-dependent|all-trans retinal binding|benzaldehyde dehydrogenase activity|NAD binding|NADPH:quinone reductase activity|retinol binding|retinol dehydrogenase activity|zinc ion binding			skin(2)	2				OV - Ovarian serous cystadenocarcinoma(123;4.48e-08)	NADH(DB00157)	ATACTTTCCACAATACCTGCA	0.403		NA											5	24					0	0	0	0
ADH1A	124	broad.mit.edu	37	4	100205642	100205642	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr4:100205642T>C	uc003hur.1	-	5	552	c.481A>G	c.(481-483)ATT>GTT	p.I161V	uc003hum.1_Intron|ADH1A_uc011ceg.1_Missense_Mutation_p.I161V|ADH1A_uc010ilf.1_5'UTR	NM_000667	NP_000658	P07327	ADH1A_HUMAN	class I alcohol dehydrogenase, alpha subunit	161					ethanol oxidation|transcription, DNA-dependent|xenobiotic metabolic process	cytosol	alcohol dehydrogenase activity, zinc-dependent|protein binding|zinc ion binding			large_intestine(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(123;9.56e-08)	Fomepizole(DB01213)|NADH(DB00157)	GCTGCATCAATTTTGGCTACT	0.493		NA											9	43					0	0	0	0
LEF1	51176	broad.mit.edu	37	4	109088757	109088757	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr4:109088757G>A	uc003hyt.1	-	1	822	c.167C>T	c.(166-168)TCC>TTC	p.S56F	LEF1_uc011cfj.1_5'Flank|LEF1_uc011cfk.1_5'Flank|LEF1_uc003hyu.1_Missense_Mutation_p.S56F|LEF1_uc003hyv.1_Missense_Mutation_p.S56F|LEF1_uc010imb.1_RNA	NM_016269	NP_057353	Q9UJU2	LEF1_HUMAN	lymphoid enhancer-binding factor 1 isoform 1	56	CTNNB1-binding (By similarity).				canonical Wnt receptor signaling pathway|cell chemotaxis|cellular response to interleukin-4|epithelial to mesenchymal transition|histone H3 acetylation|histone H4 acetylation|negative regulation of apoptosis in bone marrow|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell-cell adhesion|negative regulation of DNA binding|negative regulation of estrogen receptor binding|negative regulation of interleukin-13 production|negative regulation of interleukin-4 production|negative regulation of interleukin-5 production|negative regulation of transcription, DNA-dependent|neutrophil differentiation|osteoblast differentiation|palate development|positive regulation by host of viral transcription|positive regulation of cell cycle process|positive regulation of cell growth|positive regulation of cell migration|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of cell proliferation in bone marrow|positive regulation of cell-cell adhesion|positive regulation of epithelial to mesenchymal transition|positive regulation of granulocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|T-helper 1 cell differentiation	cytoplasm|protein-DNA complex|transcription factor complex	armadillo repeat domain binding|beta-catenin binding|C2H2 zinc finger domain binding|caspase inhibitor activity|DNA bending activity|enhancer binding|estrogen receptor activity|estrogen receptor binding|gamma-catenin binding|histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding			large_intestine(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.000224)		GTTCACCAAGGAAGACTTGAT	0.577		NA											19	89					0	0	0	0
COL25A1	84570	broad.mit.edu	37	4	110222987	110222987	+	Silent	SNP	G	G	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr4:110222987G>A	uc003hze.1	-	2	720	c.189C>T	c.(187-189)ATC>ATT	p.I63I	COL25A1_uc003hzg.2_Silent_p.I63I|COL25A1_uc003hzh.1_Silent_p.I63I	NM_198721	NP_942014	Q9BXS0	COPA1_HUMAN	collagen, type XXV, alpha 1 isoform 1	63	Extracellular (Potential).					collagen|extracellular space	beta-amyloid binding|heparin binding			ovary(2)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000173)		CGAGAGCGGCGATCCTCGCCT	0.607		NA											11	74					0	0	0	0
DCHS2	54798	broad.mit.edu	37	4	155158157	155158157	+	Silent	SNP	G	G	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr4:155158157G>A	uc003inw.2	-	25	6282	c.6282C>T	c.(6280-6282)TTC>TTT	p.F2094F		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	2094	Cadherin 18.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		ATTTGACTGTGAATTCAGGGG	0.418		NA											17	90					0	0	0	0
SEMA5A	9037	broad.mit.edu	37	5	9066574	9066574	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr5:9066574C>T	uc003jek.2	-	17	2970	c.2258G>A	c.(2257-2259)CGG>CAG	p.R753Q		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	753	TSP type-1 4.|Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						AGAACAGTACCGCATTTCGAT	0.537		NA											29	128					0	0	0	0
CDH6	1004	broad.mit.edu	37	5	31323025	31323025	+	Silent	SNP	C	C	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr5:31323025C>T	uc003jhe.1	+	12	2309	c.1983C>T	c.(1981-1983)GAC>GAT	p.D661D		NM_004932	NP_004923	P55285	CADH6_HUMAN	cadherin 6, type 2 preproprotein	661	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			ovary(4)|skin(2)|large_intestine(1)	7						GTTACAACGACGAAGGTGGTG	0.493		NA											12	66					0	0	0	0
OSMR	9180	broad.mit.edu	37	5	38933399	38933399	+	Silent	SNP	T	T	C			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr5:38933399T>C	uc003jln.1	+	18	3160	c.2793T>C	c.(2791-2793)AGT>AGC	p.S931S	OSMR_uc011cpj.1_Silent_p.S135S	NM_003999	NP_003990	Q99650	OSMR_HUMAN	oncostatin M receptor precursor	931	Cytoplasmic (Potential).				cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_lung(31;0.000365)					ACAAGGACAGTCTCCCAACAA	0.483		NA											19	171					0	0	0	0
ANKRD55	79722	broad.mit.edu	37	5	55407004	55407004	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr5:55407004G>T	uc003jqu.2	-	10	1723	c.1571C>A	c.(1570-1572)CCT>CAT	p.P524H	ANKRD55_uc003jqt.2_Missense_Mutation_p.P236H	NM_024669	NP_078945	Q3KP44	ANR55_HUMAN	ankyrin repeat domain 55 isoform 1	523										skin(1)	1		Lung NSC(810;8.69e-05)|Prostate(74;0.00634)|Breast(144;0.0334)|Ovarian(174;0.223)				TTGGTGACCAGGCCGGACACT	0.463		NA											22	168					2.22e-12	3.86e-12	1	0
MCCC2	64087	broad.mit.edu	37	5	70898414	70898414	+	Silent	SNP	G	G	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr5:70898414G>A	uc003kbs.3	+	5	603	c.465G>A	c.(463-465)CGG>CGA	p.R155R	MCCC2_uc010iyv.1_Silent_p.R155R|MCCC2_uc003kbt.3_RNA|MCCC2_uc003kbu.1_Silent_p.R24R	NM_022132	NP_071415	Q9HCC0	MCCB_HUMAN	methylcrotonoyl-Coenzyme A carboxylase 2 (beta)	155	Carboxyltransferase.		R -> Q (in MCC2 deficiency; mild form).		leucine catabolic process	mitochondrial inner membrane|mitochondrial matrix	ATP binding|methylcrotonoyl-CoA carboxylase activity			ovary(1)	1		Lung NSC(167;0.000697)|Prostate(74;0.0107)|Ovarian(174;0.0175)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;2.04e-54)	Biotin(DB00121)	AACAATTACGGGCCCAAGAAA	0.418		NA											5	43					0	0	0	0
MTX3	345778	broad.mit.edu	37	5	79282892	79282892	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr5:79282892G>T	uc010jag.2	-	7	647	c.620C>A	c.(619-621)GCA>GAA	p.A207E	MTX3_uc010jah.2_Missense_Mutation_p.A207E|MTX3_uc003kge.3_Missense_Mutation_p.A146E|MTX3_uc003kgf.1_RNA	NM_001010891	NP_001010891	Q5HYI7	MTX3_HUMAN	metaxin 3	207					protein targeting to mitochondrion	mitochondrial outer membrane					0		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.63e-45)|Epithelial(54;2.9e-40)|all cancers(79;4.68e-35)		GTAAAGAGGTGCAAGAAAACC	0.348		NA											17	44					2.35e-11	4.07e-11	1	0
WNT8A	7478	broad.mit.edu	37	5	137426351	137426351	+	Silent	SNP	G	G	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr5:137426351G>A	uc003lcd.1	+	6	650	c.645G>A	c.(643-645)GCG>GCA	p.A215A	BRD8_uc003lcc.1_Intron|WNT8A_uc011cyj.1_Silent_p.A233A|WNT8A_uc011cyk.1_Silent_p.A233A	NM_058244	NP_490645	Q9H1J5	WNT8A_HUMAN	wingless-type MMTV integration site family,	215					brain segmentation|canonical Wnt receptor signaling pathway involved in neural crest cell differentiation|cell migration involved in gastrulation|dorsal/ventral pattern formation|ectoderm development|endoderm development|eye development|hindbrain development|mesodermal cell fate commitment|negative regulation of Wnt receptor signaling pathway|neural crest cell fate commitment|neural plate pattern specification|notochord development|palate development|polarity specification of anterior/posterior axis|polarity specification of proximal/distal axis|positive regulation of fibroblast growth factor receptor signaling pathway|regulation of transcription involved in anterior/posterior axis specification|response to retinoic acid|somitogenesis|spinal cord anterior/posterior patterning|tail morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled binding|signal transducer activity			ovary(1)|lung(1)|breast(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			ATGACCAGGCGCTGAAAATTG	0.587		NA											8	41					0	0	0	0
PCDHA1	56147	broad.mit.edu	37	5	140165973	140165973	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr5:140165973A>C	uc003lhb.2	+	1	98	c.98A>C	c.(97-99)TAC>TCC	p.Y33S	PCDHA1_uc003lha.2_Missense_Mutation_p.Y33S|PCDHA1_uc003lgz.2_Missense_Mutation_p.Y33S	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	33	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGCTCCACTACTCGATCCCG	0.652		NA											12	80					0	0	0	0
PCDHA6	56142	broad.mit.edu	37	5	140209865	140209865	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr5:140209865G>A	uc003lho.2	+	1	2216	c.2189G>A	c.(2188-2190)GGC>GAC	p.G730D	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc011dab.1_Missense_Mutation_p.G730D	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	730	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCACCGAGGGCGCGTGCACG	0.682		NA											31	55					0	0	0	0
PCDHAC2	56134	broad.mit.edu	37	5	140346785	140346785	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr5:140346785C>G	uc003lii.2	+	1	674	c.434C>G	c.(433-435)TCA>TGA	p.S145*	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Intron|PCDHA13_uc003lif.2_Intron|PCDHAC1_uc003lih.2_Intron|PCDHAC2_uc011dag.1_Nonsense_Mutation_p.S145*	NM_018899	NP_061722	Q9Y5I4	PCDC2_HUMAN	protocadherin alpha subfamily C, 2 isoform 1	145	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AACGACAACTCACCGCGTTTC	0.632		NA											8	29					0	0	0	0
PCDHB10	56126	broad.mit.edu	37	5	140572211	140572211	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr5:140572211G>T	uc003lix.2	+	1	260	c.86G>T	c.(85-87)GGG>GTG	p.G29V		NM_018930	NP_061753	Q9UN67	PCDBA_HUMAN	protocadherin beta 10 precursor	29	Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCAGGTTCTGGGTTTGGACGT	0.502		NA											22	112					1.18e-14	2.07e-14	1	0
ARSI	340075	broad.mit.edu	37	5	149676799	149676799	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr5:149676799C>T	uc003lrv.2	-	2	2277	c.1688G>A	c.(1687-1689)AGG>AAG	p.R563K		NM_001012301	NP_001012301	Q5FYB1	ARSI_HUMAN	arylsulfatase family, member I precursor	563						endoplasmic reticulum|extracellular region	arylsulfatase activity|metal ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGACATTAGCCTGGTGTTGAG	0.532		NA											16	95					0	0	0	0
HIST1H4F	8361	broad.mit.edu	37	6	26240858	26240858	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr6:26240858G>T	uc003nhe.1	+	1	205	c.205G>T	c.(205-207)GAC>TAC	p.D69Y		NM_003540	NP_003531	P62805	H4_HUMAN	histone cluster 1, H4f	69					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding				0		all_hematologic(11;0.0945)|Acute lymphoblastic leukemia(11;0.167)				TGTGATACGGGACGCCGTAAC	0.587		NA											31	27					5.46e-16	9.66e-16	1	0
HIST1H3I	8354	broad.mit.edu	37	6	27840062	27840062	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr6:27840062G>A	uc003njy.2	-	1	38	c.32C>T	c.(31-33)TCC>TTC	p.S11F		NM_003533	NP_003524	P68431	H31_HUMAN	histone cluster 1, H3i	11					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)	1						GCCGCCGGTGGACTTGCGAGC	0.587		NA											5	36					0	0	0	0
ITPR3	3710	broad.mit.edu	37	6	33653966	33653966	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr6:33653966G>A	uc011drk.1	+	42	6023	c.5804G>A	c.(5803-5805)GGC>GAC	p.G1935D	ITPR3_uc003oey.2_Missense_Mutation_p.G22D	NM_002224	NP_002215	Q14573	ITPR3_HUMAN	inositol 1,4,5-triphosphate receptor, type 3	1935	Cytoplasmic (Potential).				activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			ovary(6)|lung(5)|central_nervous_system(5)|breast(2)|kidney(1)	19						GACAACGTGGGCCTCGTCATC	0.612		NA											6	22					0	0	0	0
DNAH8	1769	broad.mit.edu	37	6	38831662	38831662	+	Silent	SNP	G	G	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr6:38831662G>T	uc003ooe.1	+	43	6273	c.5673G>T	c.(5671-5673)TCG>TCT	p.S1891S		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						TTGCACAGTCGGGTTCCTGGG	0.358		NA											10	51					0.00010058	0.000160599	1	0
ZNF318	24149	broad.mit.edu	37	6	43304974	43304974	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr6:43304974C>T	uc003oux.2	-	10	6840	c.6762G>A	c.(6760-6762)ATG>ATA	p.M2254I	ZNF318_uc003ouw.2_Intron	NM_014345	NP_055160	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	2254					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			ovary(3)|breast(2)|central_nervous_system(1)|skin(1)	7			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			CCTGAGGGACCATATTGTCTT	0.463		NA											15	30					0	0	0	0
DST	667	broad.mit.edu	37	6	56495121	56495121	+	Silent	SNP	G	G	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr6:56495121G>T	uc003pdf.2	-	30	4132	c.4104C>A	c.(4102-4104)CTC>CTA	p.L1368L	DST_uc003pcz.3_Silent_p.L1190L|DST_uc011dxj.1_Silent_p.L1219L|DST_uc011dxk.1_Silent_p.L1230L|DST_uc003pcy.3_Silent_p.L864L|DST_uc003pdb.2_Silent_p.L864L|DST_uc003pdc.3_Silent_p.L864L|DST_uc003pdd.3_Silent_p.L864L	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	1190					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TAGTTTCATAGAGTTTTACGA	0.323		NA											14	73					0.000151284	0.000240251	1	0
FUT9	10690	broad.mit.edu	37	6	96651372	96651372	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr6:96651372G>C	uc003pop.3	+	3	682	c.341G>C	c.(340-342)AGT>ACT	p.S114T		NM_006581	NP_006572	Q9Y231	FUT9_HUMAN	fucosyltransferase 9 (alpha (1,3)	114	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			skin(4)|ovary(1)	5		all_cancers(76;4.77e-07)|Acute lymphoblastic leukemia(125;4.01e-09)|all_hematologic(75;1.25e-06)|all_epithelial(107;0.00279)|Colorectal(196;0.0356)		BRCA - Breast invasive adenocarcinoma(108;0.08)		CGAGACATCAGTTGGGATCTG	0.473		NA											6	54					0	0	0	0
SIM1	6492	broad.mit.edu	37	6	100895160	100895160	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr6:100895160C>T	uc003pqj.3	-	8	1189	c.982G>A	c.(982-984)GTC>ATC	p.V328I	SIM1_uc010kcu.2_Missense_Mutation_p.V328I	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	328	PAC.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		ACATAGTTGACGCTGACGATA	0.627		NA											4	31					0	0	0	0
TFB1M	51106	broad.mit.edu	37	6	155581464	155581464	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr6:155581464T>C	uc003qqj.3	-	6	801	c.737A>G	c.(736-738)GAA>GGA	p.E246G	TFB1M_uc003qqk.2_Intron	NM_016020	NP_057104	Q8WVM0	TFB1M_HUMAN	transcription factor B1, mitochondrial	246					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial nucleoid	DNA binding|protein binding|rRNA (adenine-N6,N6-)-dimethyltransferase activity			skin(1)	1		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;1.48e-12)|BRCA - Breast invasive adenocarcinoma(81;0.0131)		AACCACTTTTTCCACCAGCTT	0.438		NA											3	37					0	0	0	0
RAC1	5879	broad.mit.edu	37	7	6441634	6441634	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr7:6441634G>A	uc003spx.2	+	5	665	c.424G>A	c.(424-426)GGT>AGT	p.G142S	RAC1_uc003spw.2_Missense_Mutation_p.G161S	NM_006908	NP_008839	P63000	RAC1_HUMAN	ras-related C3 botulinum toxin substrate 1	142					actin filament polymerization|apoptosis|axon guidance|cell motility|cell-matrix adhesion|induction of apoptosis by extracellular signals|inflammatory response|lamellipodium assembly|localization within membrane|negative regulation of interleukin-23 production|negative regulation of receptor-mediated endocytosis|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of lamellipodium assembly|positive regulation of Rho protein signal transduction|regulation of cell migration|regulation of defense response to virus by virus|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst|ruffle organization|small GTPase mediated signal transduction|T cell costimulation|viral reproduction	cytosol|melanosome|plasma membrane	GTP binding|GTP-dependent protein binding|GTPase activity|thioesterase binding			lung(2)	2		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.104)	Pravastatin(DB00175)|Simvastatin(DB00641)	CTATCCGCAGGGTCTAGCCAT	0.463		NA											5	154					0	0	0	0
THSD7A	221981	broad.mit.edu	37	7	11485699	11485699	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr7:11485699C>A	uc003ssf.3	-	13	3305	c.3053G>T	c.(3052-3054)TGT>TTT	p.C1018F		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	1018	TSP type-1 10.|Extracellular (Potential).					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		ATGGCTGTTACATCTAGATGT	0.423		NA								HNSCC(18;0.044)			89	168					3.1e-51	5.71e-51	1	0
SEPT7	989	broad.mit.edu	37	7	35930338	35930338	+	Silent	SNP	C	C	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr7:35930338C>T	uc010kxc.2	+	10	1126	c.933C>T	c.(931-933)AGC>AGT	p.S311S	SEPT7_uc011kat.1_Silent_p.S310S|SEPT7_uc011kau.1_Silent_p.S275S|SEPT7_uc011kav.1_Silent_p.S258S|SEPT7_uc003tey.2_Silent_p.S159S	NM_001788	NP_001779	Q16181	SEPT7_HUMAN	cell division cycle 10 isoform 1	311					cilium morphogenesis|cytokinesis|mitosis|protein heterooligomerization|regulation of embryonic cell shape	cilium axoneme|cleavage furrow|condensed chromosome kinetochore|midbody|nucleus|septin complex|spindle|stress fiber	GTP binding|protein binding|structural molecule activity				0						ACTACAGAAGCAGAAAACTTG	0.333		NA											4	34					0	0	0	0
VPS41	27072	broad.mit.edu	37	7	38765891	38765891	+	Silent	SNP	A	A	C			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr7:38765891A>C	uc003tgy.2	-	29	2546	c.2520T>G	c.(2518-2520)GCT>GCG	p.A840A	VPS41_uc003tgz.2_Silent_p.A815A|VPS41_uc010kxn.2_Silent_p.A751A|VPS41_uc003tgx.2_RNA	NM_014396	NP_055211	P49754	VPS41_HUMAN	vacuolar protein sorting 41 isoform 1	840					Golgi vesicle transport|intracellular protein transport|vesicle-mediated transport	cytosol|Golgi-associated vesicle|HOPS complex|membrane fraction	zinc ion binding			skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4						CACGGTTCTTAGCACTGCAGA	0.363		NA											17	24					0	0	0	0
POM121L12	285877	broad.mit.edu	37	7	53104113	53104113	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr7:53104113A>T	uc003tpz.2	+	1	765	c.749A>T	c.(748-750)GAT>GTT	p.D250V		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	250											0						TTTTGTGATGATGCTTGGCCT	0.627		NA											19	97					0	0	0	0
ZNF117	51351	broad.mit.edu	37	7	64438853	64438853	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr7:64438853A>T	uc003ttr.2	-	4	2381	c.1096T>A	c.(1096-1098)TGT>AGT	p.C366S		NM_015852	NP_056936	Q03924	ZN117_HUMAN	zinc finger protein 117	366	C2H2-type 10.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1		Lung NSC(55;0.0295)|all_lung(88;0.0691)				GCTTTGCCACATTCTCCACAT	0.398		NA											11	65					0	0	0	0
GRM3	2913	broad.mit.edu	37	7	86416016	86416016	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr7:86416016G>A	uc003uid.2	+	3	2007	c.908G>A	c.(907-909)TGG>TAG	p.W303*	GRM3_uc010lef.2_Nonsense_Mutation_p.W301*|GRM3_uc010leg.2_Nonsense_Mutation_p.W175*|GRM3_uc010leh.2_Intron	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	303	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	AGCGACGGCTGGGGCGCGCAG	0.687		NA											9	38					0	0	0	0
GNG11	2791	broad.mit.edu	37	7	93555441	93555441	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr7:93555441A>T	uc003und.2	+	2	569	c.135A>T	c.(133-135)GAA>GAT	p.E45D		NM_004126	NP_004117	P61952	GBG11_HUMAN	guanine nucleotide binding protein gamma 11	45					cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway	heterotrimeric G-protein complex	GTPase activity|signal transducer activity			kidney(1)	1	all_cancers(62;2.39e-10)|all_epithelial(64;1.54e-09)|Lung NSC(181;0.218)		STAD - Stomach adenocarcinoma(171;0.000967)			ACTATATTGAAGAACGTTCTG	0.348		NA											22	81					0	0	0	0
EXOC4	60412	broad.mit.edu	37	7	133160110	133160110	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr7:133160110A>T	uc003vrk.2	+	8	1246	c.1211A>T	c.(1210-1212)AAA>ATA	p.K404I	EXOC4_uc011kpo.1_Missense_Mutation_p.K303I|EXOC4_uc003vri.2_Missense_Mutation_p.K404I|EXOC4_uc003vrj.2_Missense_Mutation_p.K404I	NM_021807	NP_068579	Q96A65	EXOC4_HUMAN	SEC8 protein isoform a	404					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			ovary(4)|large_intestine(3)|upper_aerodigestive_tract(1)|skin(1)	9		Esophageal squamous(399;0.129)				TTGGATATGAAAAATACTCGT	0.363		NA											10	99					0	0	0	0
KIAA1549	57670	broad.mit.edu	37	7	138583773	138583773	+	Silent	SNP	G	G	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr7:138583773G>A	uc011kql.1	-	9	3824	c.3775C>T	c.(3775-3777)CTG>TTG	p.L1259L	KIAA1549_uc011kqi.1_Silent_p.L43L|KIAA1549_uc003vuk.3_Silent_p.L1209L|KIAA1549_uc011kqj.1_Silent_p.L1259L|KIAA1549_uc011kqk.1_Silent_p.L43L	NM_020910	NP_065961	Q9HCM3	K1549_HUMAN	hypothetical protein LOC57670 isoform 1	1259						integral to membrane			KIAA1549/BRAF(229)	central_nervous_system(229)|pancreas(1)	230						TTGTTAATCAGGTCCGAAGAC	0.493		NA	O	BRAF	pilocytic astrocytoma								15	133					0	0	0	0
TBXAS1	6916	broad.mit.edu	37	7	139715537	139715537	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr7:139715537C>A	uc011kqv.1	+	12	1546	c.1382C>A	c.(1381-1383)GCA>GAA	p.A461E	TBXAS1_uc003vvh.2_Missense_Mutation_p.A415E|TBXAS1_uc010lne.2_Missense_Mutation_p.A347E|TBXAS1_uc011kqu.1_Missense_Mutation_p.A366E|TBXAS1_uc003vvi.2_Missense_Mutation_p.A415E|TBXAS1_uc003vvj.2_Missense_Mutation_p.A415E|TBXAS1_uc011kqw.1_Missense_Mutation_p.A395E	NM_001130966	NP_001124438	P24557	THAS_HUMAN	thromboxane A synthase 1, platelet isoform	414	Cytoplasmic (Potential).				hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|thromboxane-A synthase activity			ovary(2)|breast(1)	3	Melanoma(164;0.0142)					ACACGGGAGGCAGCTCAGGAC	0.642		NA											8	80					0.000274275	0.000428601	1	0
PARP12	64761	broad.mit.edu	37	7	139724438	139724438	+	Silent	SNP	C	C	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr7:139724438C>T	uc003vvl.1	-	12	2902	c.2028G>A	c.(2026-2028)CAG>CAA	p.Q676Q	PARP12_uc003vvk.1_Silent_p.Q462Q|PARP12_uc010lnf.1_RNA	NM_022750	NP_073587	Q9H0J9	PAR12_HUMAN	poly ADP-ribose polymerase 12	676	PARP catalytic.					nucleus	NAD+ ADP-ribosyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)	3	Melanoma(164;0.0142)					AGGTGGTGTACTGGATGACAT	0.572		NA											10	52					0	0	0	0
TRPV5	56302	broad.mit.edu	37	7	142612693	142612693	+	Silent	SNP	G	G	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr7:142612693G>A	uc003wby.1	-	9	1432	c.1168C>T	c.(1168-1170)CTG>TTG	p.L390L		NM_019841	NP_062815	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel,	390	Helical; (Potential).				protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			ovary(3)|central_nervous_system(2)|skin(1)	6	Melanoma(164;0.059)					ATGCTCACCAGCTCCCCCACC	0.547		NA											5	40					0	0	0	0
PAXIP1	22976	broad.mit.edu	37	7	154738231	154738231	+	Silent	SNP	T	T	G			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr7:154738231T>G	uc003wlp.2	-	19	3167	c.3124A>C	c.(3124-3126)AGA>CGA	p.R1042R	LOC100132707_uc011kvr.1_Intron|LOC100132707_uc003wlo.2_Intron|PAXIP1_uc003wlq.1_Silent_p.R1008R|PAXIP1_uc011kvs.1_Silent_p.R1006R	NM_007349	NP_031375	Q6ZW49	PAXI1_HUMAN	PAX interacting protein 1	1042	Interaction with TP53BP1.|BRCT 6.				DNA damage response, signal transduction by p53 class mediator|DNA recombination|DNA repair|histone H3-K4 methylation|positive regulation of histone acetylation|positive regulation of histone H3-K36 methylation|positive regulation of histone H3-K4 methylation|positive regulation of isotype switching|positive regulation of protein ubiquitination|positive regulation of transcription initiation from RNA polymerase II promoter|response to ionizing radiation|transcription, DNA-dependent	histone methyltransferase complex|nuclear matrix				lung(2)|ovary(1)|breast(1)|pancreas(1)	5	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0296)	UCEC - Uterine corpus endometrioid carcinoma (81;0.178)		CCTATGCCTCTGGCAAAATAT	0.413		NA											3	46					0	0	0	0
WRN	7486	broad.mit.edu	37	8	30977861	30977861	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr8:30977861G>T	uc003xio.3	+	21	3339	c.2551G>T	c.(2551-2553)GAG>TAG	p.E851*	WRN_uc010lvk.2_Nonsense_Mutation_p.E318*	NM_000553	NP_000544	Q14191	WRN_HUMAN	Werner syndrome protein	851	Helicase C-terminal.				base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			ovary(2)|kidney(2)|large_intestine(1)|lung(1)|skin(1)	7		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)		ATATTATCAGGAGATTGGTAG	0.393		NA	Mis|N|F|S			osteosarcoma|meningioma|others		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Werner_syndrome				18	102					3.41e-10	5.83e-10	1	0
PXDNL	137902	broad.mit.edu	37	8	52284568	52284569	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr8:52284568_52284569CC>AA	uc003xqu.3	-	19	3866_3867	c.3765_3766GG>TT	c.(3763-3768)CGGGTG>CGTTTG	p.V1256L	PXDNL_uc003xqt.3_RNA	NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	1256					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				TCACAAAGCACCCGGCTCAGGG	0.49		NA											18	17					0	0	0	0
SLC26A7	115111	broad.mit.edu	37	8	92401664	92401664	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr8:92401664G>A	uc003yex.2	+	17	2052	c.1774G>A	c.(1774-1776)GAG>AAG	p.E592K	SLC26A7_uc003yey.2_RNA|SLC26A7_uc003yez.2_Missense_Mutation_p.E592K|SLC26A7_uc003yfa.2_Missense_Mutation_p.E592K	NM_052832	NP_439897	Q8TE54	S26A7_HUMAN	solute carrier family 26, member 7 isoform a	592	STAS.|Cytoplasmic (Potential).					basolateral plasma membrane|integral to membrane|recycling endosome membrane	anion:anion antiporter activity|bicarbonate transmembrane transporter activity|chloride channel activity|oxalate transmembrane transporter activity|sulfate transmembrane transporter activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(11;0.00802)			CATGCTTGTTGAGGTATTTAT	0.413		NA											57	107					0	0	0	0
CSMD3	114788	broad.mit.edu	37	8	113241018	113241018	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr8:113241018A>G	uc003ynu.2	-	70	11090	c.10931T>C	c.(10930-10932)TTT>TCT	p.F3644S	CSMD3_uc003yns.2_Missense_Mutation_p.F2846S|CSMD3_uc003ynt.2_Missense_Mutation_p.F3604S|CSMD3_uc011lhx.1_Missense_Mutation_p.F3475S	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3644	Helical; (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AAATCCTGCAAATATAAGTGC	0.313		NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			38	34					0	0	0	0
EIF2C2	27161	broad.mit.edu	37	8	141570572	141570572	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr8:141570572C>T	uc003yvn.2	-	5	596	c.556G>A	c.(556-558)GAA>AAA	p.E186K	EIF2C2_uc010men.2_Missense_Mutation_p.E109K|EIF2C2_uc010meo.2_Missense_Mutation_p.E186K	NM_012154	NP_036286	Q9UKV8	AGO2_HUMAN	argonaute 2 isoform 1	186					mRNA cleavage involved in gene silencing by miRNA|negative regulation of translation involved in gene silencing by miRNA|negative regulation of translational initiation|pre-miRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|micro-ribonucleoprotein complex|mRNA cap binding complex|nucleus|polysome|RNA-induced silencing complex	endoribonuclease activity, cleaving siRNA-paired mRNA|metal ion binding|protein binding|RNA 7-methylguanosine cap binding|siRNA binding|translation initiation factor activity				0	all_cancers(97;2.54e-14)|all_epithelial(106;5.99e-13)|Lung NSC(106;1.45e-05)|all_lung(105;2.07e-05)|Ovarian(258;0.0154)|Acute lymphoblastic leukemia(118;0.155)	Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.158)			GAGCAGCCTTCGGACGCGGTG	0.597		NA											46	78					0	0	0	0
SLC46A2	57864	broad.mit.edu	37	9	115652267	115652267	+	Missense_Mutation	SNP	G	G	A	rs140881150		TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr9:115652267G>A	uc004bgk.2	-	1	927	c.695C>T	c.(694-696)TCG>TTG	p.S232L		NM_033051	NP_149040	Q9BY10	TSCOT_HUMAN	solute carrier family 46, member 2	232	Cytoplasmic (Potential).					integral to membrane|plasma membrane	symporter activity			central_nervous_system(1)	1						TTTGGCCACCGACTCAGGGAC	0.607		NA											13	41					0	0	0	0
ASTN2	23245	broad.mit.edu	37	9	119976974	119976974	+	Silent	SNP	C	C	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr9:119976974C>A	uc004bjs.1	-	3	779	c.678G>T	c.(676-678)GCG>GCT	p.A226A	ASTN2_uc004bjr.1_Silent_p.A226A|ASTN2_uc004bjt.1_Silent_p.A226A	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	226	Helical; (Potential).					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						GGGCGTACAGCGCCACGGTGA	0.602		NA											25	29					4.78e-09	8.12e-09	1	0
UCK1	83549	broad.mit.edu	37	9	134404963	134404963	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr9:134404963C>G	uc004cay.2	-	3	378	c.277G>C	c.(277-279)GAT>CAT	p.D93H	UCK1_uc010mzk.2_Missense_Mutation_p.D84H|UCK1_uc004cba.2_Missense_Mutation_p.D93H|UCK1_uc004caz.2_RNA	NM_031432	NP_113620	Q9HA47	UCK1_HUMAN	uridine-cytidine kinase 1 isoform a	93					pyrimidine base metabolic process|pyrimidine nucleoside salvage	cytosol	ATP binding|phosphotransferase activity, alcohol group as acceptor|uridine kinase activity				0				OV - Ovarian serous cystadenocarcinoma(145;2.34e-05)|Epithelial(140;0.000219)		AAATCATTATCAAAGGCATCT	0.547		NA											17	91					0	0	0	0
WDR5	11091	broad.mit.edu	37	9	137017113	137017113	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr9:137017113G>A	uc004cey.2	+	9	764	c.593G>A	c.(592-594)TGG>TAG	p.W198*	WDR5_uc004cez.2_Nonsense_Mutation_p.W198*	NM_017588	NP_060058	P61964	WDR5_HUMAN	WD repeat domain 5	198	WD 4.				histone H3 acetylation|histone H3-K4 methylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ada2/Gcn5/Ada3 transcription activator complex|MLL1 complex|Set1C/COMPASS complex	protein binding				0		Myeloproliferative disorder(178;0.0255)|Medulloblastoma(224;0.123)		Epithelial(140;6.61e-13)|all cancers(34;5.66e-12)|OV - Ovarian serous cystadenocarcinoma(145;3.93e-08)|GBM - Glioblastoma multiforme(294;0.00326)|READ - Rectum adenocarcinoma(205;0.154)		AGTCGCATCTGGGACACCGCC	0.557		NA											17	160					0	0	0	0
AKAP4	8852	broad.mit.edu	37	X	49957554	49957554	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chrX:49957554G>A	uc004dow.1	-	5	1934	c.1810C>T	c.(1810-1812)CAC>TAC	p.H604Y	AKAP4_uc004dov.1_Missense_Mutation_p.H221Y|AKAP4_uc010njp.1_Missense_Mutation_p.H426Y|AKAP4_uc004dou.1_Missense_Mutation_p.H595Y	NM_003886	NP_003877	Q5JQC9	AKAP4_HUMAN	A-kinase anchor protein 4 isoform 1	604					cell projection organization|single fertilization|sperm motility	cAMP-dependent protein kinase complex|cilium|cytoskeleton|microtubule-based flagellum	protein kinase A binding			kidney(3)|central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	8	Ovarian(276;0.236)					GGGGCTCTGTGAGATTCTAGT	0.458		NA											18	27					0	0	0	0
H2BFWT	158983	broad.mit.edu	37	X	103268089	103268089	+	Silent	SNP	T	T	C			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chrX:103268089T>C	uc004elr.2	-	1	168	c.144A>G	c.(142-144)AAA>AAG	p.K48K		NM_001002916	NP_001002916	Q7Z2G1	H2BWT_HUMAN	H2B histone family, member W, testis-specific	48					nucleosome assembly	nuclear membrane|nucleosome	DNA binding			ovary(1)	1						AGTTGGCCTCTTTGGGCTCCT	0.627		NA											7	10					0	0	0	0
HNRNPR	10236	broad.mit.edu	37	1	23637236	23637241	+	In_Frame_Del	DEL	GGTCCC	GGTCCC	-			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr1:23637236_23637241delGGTCCC	uc001bgr.3	-	11	1767_1772	c.1608_1613delGGGACC	c.(1606-1614)TTGGGACCA>TTA	p.GP537del	HNRNPR_uc001bgo.2_In_Frame_Del_p.GP147del|HNRNPR_uc001bgp.3_In_Frame_Del_p.GP540del|HNRNPR_uc009vqk.2_In_Frame_Del_p.GP439del|HNRNPR_uc001bgs.3_In_Frame_Del_p.GP436del|HNRNPR_uc010odw.1_In_Frame_Del_p.GP499del|HNRNPR_uc010odx.1_In_Frame_Del_p.GP377del|HNRNPR_uc009vql.2_In_Frame_Del_p.GP398del	NM_005826	NP_005817	O43390	HNRPR_HUMAN	heterogeneous nuclear ribonucleoprotein R	537_538	RNA-binding RGG-box.					catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding			upper_aerodigestive_tract(1)|skin(1)	2		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00394)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;6.83e-27)|Colorectal(126;6.01e-08)|COAD - Colon adenocarcinoma(152;3.32e-06)|GBM - Glioblastoma multiforme(114;6.69e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|KIRC - Kidney renal clear cell carcinoma(1967;0.00357)|STAD - Stomach adenocarcinoma(196;0.0131)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0875)|LUSC - Lung squamous cell carcinoma(448;0.19)		GCCTCTTGGTGGTCCCAAAGGTGCCC	0.568		NA											14	75	---	---	---	---	NA	NA	NA	NA
B3GAT3	26229	broad.mit.edu	37	11	62388037	62388038	+	Frame_Shift_Ins	INS	-	-	G			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr11:62388037_62388038insG	uc001ntw.2	-	2	217_218	c.188_189insC	c.(187-189)CCTfs	p.P63fs	B3GAT3_uc009ynz.2_Frame_Shift_Ins_p.P56fs|B3GAT3_uc001ntx.2_RNA|B3GAT3_uc010rlz.1_Frame_Shift_Ins_p.P63fs	NM_012200	NP_036332	O94766	B3GA3_HUMAN	beta-1,3-glucuronyltransferase 3	63	Lumenal (Potential).				glycosaminoglycan biosynthetic process	Golgi membrane|integral to membrane	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|manganese ion binding				0						GGGCAGGGGCAGGGGGTGGCCG	0.634		NA											7	44	---	---	---	---	NA	NA	NA	NA
EMG1	10436	broad.mit.edu	37	12	7080212	7080213	+	Splice_Site	INS	-	-	C	rs17857448		TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr12:7080212_7080213insC	uc001qsh.3	+	2	272	c.129_splice	c.e2+1	p.L43_splice	PHB2_uc001qsd.2_5'Flank|PHB2_uc010sft.1_5'Flank|PHB2_uc010sfu.1_5'Flank|EMG1_uc009zfo.2_RNA|EMG1_uc010sfv.1_RNA	NM_006331	NP_006322	Q92979	NEP1_HUMAN	ribosome biogenesis protein NEP1						ribosomal small subunit biogenesis	cytoplasm|nucleolus	rRNA (pseudouridine) methyltransferase activity|rRNA binding				0						GAGGCCGTAGTTTATTGTGGTG	0.569		NA											7	28	---	---	---	---	NA	NA	NA	NA
SLFN5	162394	broad.mit.edu	37	17	33592632	33592633	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr17:33592632_33592633insA	uc002hjf.3	+	5	2518_2519	c.2401_2402insA	c.(2401-2403)GAAfs	p.E801fs	SLFN5_uc010wcg.1_3'UTR	NM_144975	NP_659412	Q08AF3	SLFN5_HUMAN	schlafen family member 5	801					cell differentiation		ATP binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0191)		AAGTGAAGTGGAAAAATATAAA	0.426		NA											16	72	---	---	---	---	NA	NA	NA	NA
C19orf2	8725	broad.mit.edu	37	19	30433493	30433494	+	Frame_Shift_Ins	INS	-	-	C			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr19:30433493_30433494insC	uc002nsr.2	+	1	69_70	c.39_40insC	c.(37-42)TCGCCCfs	p.S13fs	C19orf2_uc002nsq.2_Intron|C19orf2_uc002nss.2_5'UTR	NM_003796	NP_003787	O94763	RMP_HUMAN	RPB5-mediating protein isoform a	13_14					protein folding|regulation of transcription from RNA polymerase II promoter|response to virus	DNA-directed RNA polymerase II, core complex|prefoldin complex	transcription corepressor activity|unfolded protein binding			ovary(1)|kidney(1)	2	Ovarian(5;0.000902)|Breast(6;0.0203)|Esophageal squamous(110;0.195)	Hepatocellular(1079;0.137)|Renal(1328;0.228)	STAD - Stomach adenocarcinoma(5;5.36e-06)|Lung(7;0.0144)|LUAD - Lung adenocarcinoma(5;0.115)	STAD - Stomach adenocarcinoma(1328;0.18)		CCGACCCCTCGCCCCCTTCGGC	0.762		NA											3	6	---	---	---	---	NA	NA	NA	NA
TBC1D14	57533	broad.mit.edu	37	4	7026838	7026848	+	Frame_Shift_Del	DEL	TCCTGAAGCTG	TCCTGAAGCTG	-			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr4:7026838_7026848delTCCTGAAGCTG	uc011bwg.1	+	13	1944_1954	c.1865_1875delTCCTGAAGCTG	c.(1864-1875)ATCCTGAAGCTGfs	p.I622fs	TBC1D14_uc003gjs.3_Frame_Shift_Del_p.I622fs|TBC1D14_uc010idh.2_Frame_Shift_Del_p.I342fs|TBC1D14_uc011bwh.1_Frame_Shift_Del_p.I269fs|TBC1D14_uc003gju.3_Frame_Shift_Del_p.I113fs	NM_001113361	NP_001106832	Q9P2M4	TBC14_HUMAN	TBC1 domain family, member 14 isoform a	622_625						intracellular	Rab GTPase activator activity			ovary(1)|pancreas(1)	2						GCCCTGGGCATCCTGAAGCTGTTCGAGGACA	0.588		NA											19	88	---	---	---	---	NA	NA	NA	NA
CADPS2	93664	broad.mit.edu	37	7	122153341	122153341	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chr7:122153341delA	uc010lkp.2	-	9	1667	c.1504delT	c.(1504-1506)TGGfs	p.W502fs	CADPS2_uc003vkg.3_Frame_Shift_Del_p.W202fs|CADPS2_uc010lkq.2_Frame_Shift_Del_p.W502fs	NM_017954	NP_060424	Q86UW7	CAPS2_HUMAN	Ca2+-dependent activator protein for secretion 2	502	PH.				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding			ovary(1)|central_nervous_system(1)	2						CATCTTTTCCAAACCTTCTGT	0.313		NA											2	4	---	---	---	---	NA	NA	NA	NA
KDM5C	8242	broad.mit.edu	37	X	53240037	53240038	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CR-7367-01A-11D-2012-08	TCGA-CR-7367-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b82e34db-7b0e-4bbd-bc42-ba063ac42409	b93dc36c-99c1-4b6d-88c1-97d65bad89d2	g.chrX:53240037_53240038insA	uc004drz.2	-	11	1936_1937	c.1403_1404insT	c.(1402-1404)GAGfs	p.E468fs	KDM5C_uc011moc.1_RNA|KDM5C_uc011mod.1_Frame_Shift_Ins_p.E401fs|KDM5C_uc004dsa.2_Frame_Shift_Ins_p.E467fs	NM_004187	NP_004178	P41229	KDM5C_HUMAN	jumonji, AT rich interactive domain 1C isoform	468	JmjC.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			kidney(9)|ovary(5)|salivary_gland(1)|autonomic_ganglia(1)|haematopoietic_and_lymphoid_tissue(1)|oesophagus(1)	18						TGGTAGCATACTCCTGCCAGGT	0.455		NA	N|F|S		clear cell renal carcinoma								17	33	---	---	---	---	NA	NA	NA	NA