Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
HCRTR1	3061	broad.mit.edu	37	1	32089283	32089283	+	Silent	SNP	C	C	T			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr1:32089283C>T	uc009vtx.2	+	7	1283	c.898C>T	c.(898-900)CTG>TTG	p.L300L	HCRTR1_uc001btb.2_Silent_p.L125L|HCRTR1_uc001btc.3_Silent_p.L214L|HCRTR1_uc001btd.2_Silent_p.L300L|HCRTR1_uc010ogl.1_Silent_p.L300L	NM_001525	NP_001516	O43613	OX1R_HUMAN	orexin receptor 1	300	Helical; Name=6; (Potential).				feeding behavior|neuropeptide signaling pathway|synaptic transmission	integral to plasma membrane				ovary(1)	1		Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.053)		AGCCAAGATGCTGATGGTGGT	0.632		NA											8	46					0	0	0	0
DLGAP3	58512	broad.mit.edu	37	1	35365842	35365842	+	Silent	SNP	G	G	A	rs149715442		TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr1:35365842G>A	uc001byc.2	-	2	1140	c.1140C>T	c.(1138-1140)ACC>ACT	p.T380T		NM_001080418	NP_001073887	O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated	380					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane				ovary(3)	3		Myeloproliferative disorder(586;0.0393)				CCTTGCCACCGGTGGGGTAAC	0.612		NA											34	122					0	0	0	0
LRIG2	9860	broad.mit.edu	37	1	113661886	113661886	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr1:113661886T>G	uc001edf.1	+	17	2910	c.2712T>G	c.(2710-2712)GAT>GAG	p.D904E	LRIG2_uc009wgn.1_Missense_Mutation_p.D801E	NM_014813	NP_055628	O94898	LRIG2_HUMAN	leucine-rich repeats and immunoglobulin-like	904	Cytoplasmic (Potential).					cytoplasm|integral to membrane|plasma membrane				ovary(3)	3	Lung SC(450;0.246)	all_cancers(81;1.56e-05)|all_epithelial(167;2.62e-05)|all_lung(203;0.000665)|Lung NSC(69;0.000986)		Lung(183;0.0279)|Colorectal(144;0.0885)|COAD - Colon adenocarcinoma(174;0.134)|all cancers(265;0.139)|Epithelial(280;0.143)|LUSC - Lung squamous cell carcinoma(189;0.15)		TTTGCTCAGATTGTTATGACA	0.413		NA											23	80					0	0	0	0
SPTA1	6708	broad.mit.edu	37	1	158596754	158596754	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr1:158596754A>G	uc001fst.1	-	41	5907	c.5708T>C	c.(5707-5709)ATA>ACA	p.I1903T		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1903	Spectrin 18.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					CAGAGCCTCTATCTTGGAAGA	0.428		NA											29	97					0	0	0	0
TNFSF4	7292	broad.mit.edu	37	1	173155865	173155865	+	Silent	SNP	G	G	A			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr1:173155865G>A	uc001giw.2	-	3	498	c.342C>T	c.(340-342)AAC>AAT	p.N114N	TNFSF4_uc001giv.2_Silent_p.N64N	NM_003326	NP_003317	P23510	TNFL4_HUMAN	tumor necrosis factor (ligand) superfamily,	114	Extracellular (Potential).				acute inflammatory response|cellular response to lipopolysaccharide|cellular response to prostaglandin E stimulus|chemokine (C-C motif) ligand 11 production|defense response to nematode|interleukin-4-dependent isotype switching to IgE isotypes|memory T cell activation|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of regulatory T cell differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of T-helper 1 cell differentiation|negative regulation of transcription, DNA-dependent|positive regulation of alpha-beta T cell proliferation|positive regulation of B cell activation|positive regulation of immunoglobulin mediated immune response|positive regulation of immunoglobulin secretion|positive regulation of inflammatory response|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-13 production|positive regulation of interleukin-4 production|positive regulation of interleukin-6 production|positive regulation of memory T cell differentiation|positive regulation of T cell cytokine production|positive regulation of T-helper 2 cell differentiation|positive regulation of type 2 immune response|response to virus|signal transduction|T-helper 2 cell activation	cell surface|extracellular space|integral to plasma membrane	cytokine activity			central_nervous_system(1)	1						GAAGGCTAATGTTGACTTCCT	0.468		NA											13	48					0	0	0	0
ASTN1	460	broad.mit.edu	37	1	176998825	176998825	+	Silent	SNP	G	G	A	rs61758728		TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr1:176998825G>A	uc001glc.2	-	5	1277	c.1065C>T	c.(1063-1065)AAC>AAT	p.N355N	ASTN1_uc001glb.1_Silent_p.N355N|ASTN1_uc001gld.1_Silent_p.N355N|ASTN1_uc009wwx.1_Silent_p.N355N|ASTN1_uc001gle.3_RNA|MIR488_hsa-mir-488|MI0003123_5'Flank	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	355					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						GCTGGGGGTCGTTTTCTGCCT	0.507		NA											17	13					0	0	0	0
FAM5C	339479	broad.mit.edu	37	1	190129849	190129849	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr1:190129849C>A	uc001gse.1	-	7	1365	c.1133G>T	c.(1132-1134)AGC>ATC	p.S378I	FAM5C_uc010pot.1_Missense_Mutation_p.S276I	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	378						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					CTTGCTAAGGCTAAAAAGCTT	0.393		NA											39	44					9.85e-19	1.2e-18	1	0
EPHX1	2052	broad.mit.edu	37	1	226027611	226027611	+	Silent	SNP	C	C	T			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr1:226027611C>T	uc001hpk.2	+	6	884	c.804C>T	c.(802-804)TTC>TTT	p.F268F	EPHX1_uc001hpl.2_Silent_p.F268F	NM_001136018	NP_001129490	P07099	HYEP_HUMAN	epoxide hydrolase 1	268					aromatic compound catabolic process|response to toxin	endoplasmic reticulum membrane|integral to membrane|microsome	cis-stilbene-oxide hydrolase activity|epoxide hydrolase activity			ovary(3)|lung(1)	4	Breast(184;0.197)					GACAGCGTTTCGGGAGGTTTC	0.552		NA											41	147					0	0	0	0
TUBAL3	79861	broad.mit.edu	37	10	5435651	5435651	+	Silent	SNP	C	C	T			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr10:5435651C>T	uc001ihy.2	-	4	1210	c.1170G>A	c.(1168-1170)GCG>GCA	p.A390A	TUBAL3_uc001ihz.2_Silent_p.A350A	NM_024803	NP_079079	A6NHL2	TBAL3_HUMAN	tubulin, alpha-like 3	390					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			skin(1)	1						CCTCCACAATCGCCGTGGTGT	0.592		NA											31	46					0	0	0	0
BICC1	80114	broad.mit.edu	37	10	60549208	60549208	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr10:60549208G>A	uc001jki.1	+	7	787	c.787G>A	c.(787-789)GCT>ACT	p.A263T		NM_001080512	NP_001073981	Q9H694	BICC1_HUMAN	bicaudal C homolog 1	263					multicellular organismal development		RNA binding			ovary(2)|lung(1)|skin(1)	4						TAACACTAGTGCTGTGAAGGT	0.328		NA											31	36					0	0	0	0
LRRTM3	347731	broad.mit.edu	37	10	68686715	68686715	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr10:68686715T>C	uc001jmz.1	+	2	591	c.41T>C	c.(40-42)GTA>GCA	p.V14A	CTNNA3_uc009xpn.1_Intron|CTNNA3_uc001jmw.2_Intron|CTNNA3_uc001jmx.3_Intron|CTNNA3_uc009xpo.1_Intron|LRRTM3_uc001jmy.2_Missense_Mutation_p.V14A	NM_178011	NP_821079	Q86VH5	LRRT3_HUMAN	leucine rich repeat transmembrane neuronal 3	14						integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						GGATCAGCTGTAGCACTGGTT	0.413		NA											22	28					0	0	0	0
OR4C16	219428	broad.mit.edu	37	11	55339991	55339991	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr11:55339991T>A	uc010rih.1	+	1	388	c.388T>A	c.(388-390)TAC>AAC	p.Y130N		NM_001004701	NP_001004701	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C,	130	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		all_epithelial(135;0.0748)				GCCCCTGCACTACATGACCAT	0.502		NA											61	95					0	0	0	0
OR5L2	26338	broad.mit.edu	37	11	55594850	55594850	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr11:55594850C>A	uc001nhy.1	+	1	156	c.156C>A	c.(154-156)AGC>AGA	p.S52R		NM_001004739	NP_001004739	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L,	52	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_epithelial(135;0.208)				TTCAGGTCAGCTCTCGGCTCC	0.478		NA								HNSCC(27;0.073)			101	220					4.49e-49	5.53e-49	1	0
MTA2	9219	broad.mit.edu	37	11	62362870	62362870	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr11:62362870T>C	uc001ntq.1	-	14	1730	c.1349A>G	c.(1348-1350)AAC>AGC	p.N450S	MTA2_uc010rlx.1_Missense_Mutation_p.N277S	NM_004739	NP_004730	O94776	MTA2_HUMAN	metastasis-associated protein 2	450					chromatin assembly or disassembly	NuRD complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						AGTTTGTCTGTTCTTAGCCAG	0.537		NA											69	71					0	0	0	0
PRKRIR	5612	broad.mit.edu	37	11	76061960	76061960	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr11:76061960G>C	uc001oxh.1	-	5	2234	c.2234C>G	c.(2233-2235)ACA>AGA	p.T745R	PRKRIR_uc010rrz.1_Missense_Mutation_p.T570R	NM_004705	NP_004696	O43422	P52K_HUMAN	protein-kinase, interferon-inducible double	745					negative regulation of cell proliferation|response to stress|signal transduction		DNA binding|metal ion binding|protein dimerization activity	p.T745R(1)		ovary(2)|pancreas(1)	3						TGACTTACTTGTATAGAGTTT	0.313		NA											6	23					0	0	0	0
DYNC2H1	79659	broad.mit.edu	37	11	102988373	102988373	+	Silent	SNP	A	A	T			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr11:102988373A>T	uc001pho.2	+	6	924	c.780A>T	c.(778-780)GGA>GGT	p.G260G	DYNC2H1_uc001phn.1_Silent_p.G260G|DYNC2H1_uc009yxe.1_Silent_p.G260G	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	260	Stem (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		GTTCATTTGGAAGGTTTGTTC	0.279		NA											11	356					0	0	0	0
H2AFJ	55766	broad.mit.edu	37	12	14927722	14927722	+	Silent	SNP	C	C	T			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr12:14927722C>T	uc009zia.2	+	1	453	c.318C>T	c.(316-318)GGC>GGT	p.G106G	H2AFJ_uc001rch.3_RNA	NM_177925	NP_808760	Q9BTM1	H2AJ_HUMAN	H2A histone family, member J	106					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)	1						TCGCTCAGGGCGGCGTCCTGC	0.597		NA											4	108					0	0	0	0
HELB	92797	broad.mit.edu	37	12	66717930	66717930	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr12:66717930A>G	uc001sti.2	+	10	2493	c.2465A>G	c.(2464-2466)AAT>AGT	p.N822S	HELB_uc010ssz.1_RNA|HELB_uc009zqt.1_RNA	NM_033647	NP_387467	Q8NG08	HELB_HUMAN	helicase (DNA) B	822					DNA replication, synthesis of RNA primer		ATP binding|ATP-dependent 5'-3' DNA helicase activity|single-stranded DNA-dependent ATP-dependent DNA helicase activity			central_nervous_system(1)|pancreas(1)	2			GBM - Glioblastoma multiforme(2;0.000142)	GBM - Glioblastoma multiforme(28;0.0265)		TTTGCTAAAAATAAGCGTGAC	0.333		NA											11	42					0	0	0	0
TMEM132D	121256	broad.mit.edu	37	12	130185156	130185156	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr12:130185156G>A	uc009zyl.1	-	2	495	c.167C>T	c.(166-168)GCG>GTG	p.A56V		NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	56	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		GGAGACGTCCGCGTTGTTGAT	0.557		NA											27	36					0	0	0	0
PCK2	5106	broad.mit.edu	37	14	24572431	24572431	+	Missense_Mutation	SNP	C	C	T	rs145351624		TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr14:24572431C>T	uc001wlt.2	+	9	1567	c.1435C>T	c.(1435-1437)CGC>TGC	p.R479C	NRL_uc001wlq.2_Intron|PCK2_uc001wlr.1_Missense_Mutation_p.R491C|PCK2_uc010tnw.1_Missense_Mutation_p.R345C|PCK2_uc010tnx.1_Missense_Mutation_p.R345C|PCK2_uc001wlu.3_Intron	NM_004563	NP_004554	Q16822	PCKGM_HUMAN	mitochondrial phosphoenolpyruvate carboxykinase	479					gluconeogenesis	mitochondrial matrix	GTP binding|metal ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			ovary(1)	1				GBM - Glioblastoma multiforme(265;0.0184)		CAGCGCCATGCGCTCTGAGTC	0.572		NA											3	26					0	0	0	0
NFATC4	4776	broad.mit.edu	37	14	24842446	24842446	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr14:24842446C>T	uc001wpc.2	+	4	1750	c.1429C>T	c.(1429-1431)CGG>TGG	p.R477W	NFATC4_uc010tok.1_Missense_Mutation_p.R540W|NFATC4_uc010tol.1_Missense_Mutation_p.R540W|NFATC4_uc010alr.2_Missense_Mutation_p.R540W|NFATC4_uc010als.2_Missense_Mutation_p.R490W|NFATC4_uc010tom.1_Missense_Mutation_p.R490W|NFATC4_uc010ton.1_Missense_Mutation_p.R490W|NFATC4_uc010too.1_Missense_Mutation_p.R490W|NFATC4_uc010alt.2_Missense_Mutation_p.R509W|NFATC4_uc010top.1_Missense_Mutation_p.R509W|NFATC4_uc010toq.1_Missense_Mutation_p.R509W|NFATC4_uc010alu.2_Missense_Mutation_p.R169W|NFATC4_uc010tor.1_Missense_Mutation_p.R477W|NFATC4_uc010tos.1_Missense_Mutation_p.R407W|NFATC4_uc010tot.1_Missense_Mutation_p.R465W|NFATC4_uc010tou.1_Missense_Mutation_p.R407W|NFATC4_uc010tov.1_Missense_Mutation_p.R465W|NFATC4_uc010tow.1_Missense_Mutation_p.R407W|NFATC4_uc010alv.2_Missense_Mutation_p.R465W|NFATC4_uc010tox.1_Missense_Mutation_p.R407W|NFATC4_uc001wpd.2_Missense_Mutation_p.R12W|NFATC4_uc010toy.1_Missense_Mutation_p.R12W|NFATC4_uc010toz.1_Missense_Mutation_p.R12W|NFATC4_uc010tpa.1_5'Flank|NFATC4_uc010tpb.1_5'Flank	NM_004554	NP_004545	Q14934	NFAC4_HUMAN	nuclear factor of activated T-cells,	477	RHD.				cell differentiation|inflammatory response|transcription from RNA polymerase II promoter	cytoplasm|intermediate filament cytoskeleton|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(265;0.018)		AAGGAACCTGCGGCCTCATGC	0.567		NA											12	42					0	0	0	0
C14orf49	161176	broad.mit.edu	37	14	95921839	95921839	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr14:95921839T>G	uc001yei.3	-	5	1027	c.1012A>C	c.(1012-1014)AAG>CAG	p.K338Q	C14orf49_uc010avi.2_Missense_Mutation_p.K338Q|C14orf49_uc001yej.1_Missense_Mutation_p.K338Q	NM_152592	NP_689805	Q6ZMZ3	SYNE3_HUMAN	nesprin-3	338	Cytoplasmic (Potential).				cytoskeletal anchoring at nuclear membrane	integral to membrane|nuclear outer membrane|SUN-KASH complex	actin binding			central_nervous_system(1)	1		all_cancers(154;0.0937)		COAD - Colon adenocarcinoma(157;0.245)		TCCAGCTGCTTAATCTGCTGC	0.667		NA											3	114					0	0	0	0
HERC2	8924	broad.mit.edu	37	15	28389924	28389924	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr15:28389924C>T	uc001zbj.2	-	72	11141	c.11035G>A	c.(11035-11037)GAG>AAG	p.E3679K		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	3679					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		ATGCGCAGCTCGCTGGACCAG	0.572		NA											15	34					0	0	0	0
DHX33	56919	broad.mit.edu	37	17	5357145	5357145	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr17:5357145G>A	uc002gca.2	-	7	1305	c.1303C>T	c.(1303-1305)CAG>TAG	p.Q435*	DHX33_uc002gbz.2_Nonsense_Mutation_p.Q206*|DHX33_uc002gcb.2_Nonsense_Mutation_p.Q262*|DHX33_uc010clf.2_Nonsense_Mutation_p.Q211*	NM_020162	NP_064547	Q9H6R0	DHX33_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 33	435	Helicase C-terminal.					nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|pancreas(1)	2						GCCTACCTCTGGATCTCTGGC	0.562		NA											5	41					0	0	0	0
EPN2	22905	broad.mit.edu	37	17	19188962	19188962	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr17:19188962C>T	uc002gvd.3	+	4	1073	c.625C>T	c.(625-627)CGC>TGC	p.R209C	EPN2_uc010cql.1_Intron|EPN2_uc002gve.3_Intron|EPN2_uc002gvf.3_Intron|EPN2_uc010vyo.1_Intron|EPN2_uc002gvg.1_Intron|EPN2_uc010vyp.1_Intron|EPN2_uc010vyq.1_Intron|EPN2_uc002gvh.1_Missense_Mutation_p.R209C	NM_014964	NP_055779	O95208	EPN2_HUMAN	epsin 2 isoform b	209					endocytosis		lipid binding			skin(1)	1	all_cancers(12;3.11e-05)|all_epithelial(12;0.00121)|Hepatocellular(7;0.00345)|Breast(13;0.143)					cccccagcaccgcacaggggc	0.284		NA											3	10					0	0	0	0
TLCD1	116238	broad.mit.edu	37	17	27051713	27051713	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr17:27051713G>C	uc002hco.2	-	4	674	c.559C>G	c.(559-561)CAG>GAG	p.Q187E	TLCD1_uc010waw.1_Missense_Mutation_p.Q140E	NM_138463	NP_612472	Q96CP7	TLCD1_HUMAN	TLC domain containing 1 isoform 1	187	TLC.|Helical; (Potential).					integral to membrane					0	Lung NSC(42;0.00431)					AGGTAGGCCTGAGGGGCCAGG	0.502		NA											7	108					0	0	0	0
AATK	9625	broad.mit.edu	37	17	79108261	79108261	+	Silent	SNP	G	G	A			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr17:79108261G>A	uc010dia.2	-	2	176	c.96C>T	c.(94-96)CTC>CTT	p.L32L	MIR1250_hsa-mir-1250|MI0006385_5'Flank	NM_001080395	NP_001073864	Q6ZMQ8	LMTK1_HUMAN	apoptosis-associated tyrosine kinase	32	Helical; (Potential).					integral to membrane|mitochondrion|perinuclear region of cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			stomach(4)|ovary(2)|lung(2)|upper_aerodigestive_tract(1)	9	all_neural(118;0.101)		BRCA - Breast invasive adenocarcinoma(99;0.0228)|OV - Ovarian serous cystadenocarcinoma(97;0.0524)			CCACCACGGCGAGGGAGGATG	0.677		NA											16	25					0	0	0	0
ZNF24	7572	broad.mit.edu	37	18	32917689	32917689	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr18:32917689T>C	uc002kyt.2	-	4	771	c.614A>G	c.(613-615)GAG>GGG	p.E205G	ZNF24_uc002kys.2_Missense_Mutation_p.E205G	NM_006965	NP_008896	P17028	ZNF24_HUMAN	zinc finger protein 24	205					myelination|negative regulation of transcription, DNA-dependent|viral reproduction	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						TGAAGGAAGCTCCTGCTTTGG	0.388		NA											56	42					0	0	0	0
NEDD4L	23327	broad.mit.edu	37	18	55996286	55996286	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr18:55996286G>A	uc002lgy.2	+	10	1014	c.740G>A	c.(739-741)CGG>CAG	p.R247Q	NEDD4L_uc002lgz.2_Missense_Mutation_p.R247Q|NEDD4L_uc002lgx.2_Missense_Mutation_p.R247Q|NEDD4L_uc010xee.1_Missense_Mutation_p.R126Q|NEDD4L_uc002lhc.2_Missense_Mutation_p.R239Q|NEDD4L_uc002lhd.2_Missense_Mutation_p.R126Q|NEDD4L_uc002lhb.2_Missense_Mutation_p.R126Q|NEDD4L_uc002lhe.2_Missense_Mutation_p.R239Q|NEDD4L_uc002lhf.2_Missense_Mutation_p.R126Q|NEDD4L_uc002lhg.2_Missense_Mutation_p.R126Q|NEDD4L_uc002lhh.2_Missense_Mutation_p.R126Q|NEDD4L_uc010dpm.1_Missense_Mutation_p.R98Q	NM_001144967	NP_001138439	Q96PU5	NED4L_HUMAN	neural precursor cell expressed, developmentally	247					cellular sodium ion homeostasis|excretion|interspecies interaction between organisms|positive regulation of endocytosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of protein catabolic process|response to metal ion|sodium ion transport|water homeostasis	cytoplasm	protein binding|sodium channel regulator activity|ubiquitin-protein ligase activity			lung(4)	4						GCAGCACACCGGCGCTTCCGC	0.602		NA											22	14					0	0	0	0
TLE6	79816	broad.mit.edu	37	19	2987144	2987144	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr19:2987144A>G	uc002lwu.2	+	6	480	c.80A>G	c.(79-81)AAG>AGG	p.K27R	TLE6_uc002lwt.2_Missense_Mutation_p.K150R|TLE6_uc010dtg.2_Missense_Mutation_p.K150R|TLE6_uc002lwv.2_5'Flank	NM_024760	NP_079036	Q9H808	TLE6_HUMAN	transducin-like enhancer of split 6 isoform 2	27					regulation of transcription, DNA-dependent	nucleus				ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TTCTGGGACAAGGAGCCTTGG	0.597		NA											19	89					0	0	0	0
ZNF208	7757	broad.mit.edu	37	19	22156143	22156143	+	Missense_Mutation	SNP	A	A	G	rs112237751		TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr19:22156143A>G	uc002nqp.2	-	5	1542	c.1393T>C	c.(1393-1395)TCC>CCC	p.S465P	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				AGGGTTGAGGACCACTTATAG	0.348		NA											3	56					0	0	0	0
WDR62	284403	broad.mit.edu	37	19	36550887	36550887	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr19:36550887T>G	uc002odc.2	+	3	378	c.287T>G	c.(286-288)TTG>TGG	p.L96W	WDR62_uc002odd.2_Missense_Mutation_p.L96W|WDR62_uc010eer.2_Missense_Mutation_p.L96W|WDR62_uc002odb.2_Missense_Mutation_p.L96W	NM_173636	NP_775907	O43379	WDR62_HUMAN	WD repeat domain 62 isoform 2	96					cerebral cortex development	nucleus					0	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			GTGGTGATTTTGGACCCCAAG	0.582		NA											3	156					0	0	0	0
EID2	163126	broad.mit.edu	37	19	40030302	40030302	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr19:40030302G>A	uc002oma.2	-	1	537	c.418C>T	c.(418-420)CTC>TTC	p.L140F		NM_153232	NP_694964	Q8N6I1	EID2_HUMAN	CREBBP/EP300 inhibitor 2	140					cell differentiation|muscle organ development|negative regulation of transcription, DNA-dependent|negative regulation of transforming growth factor beta receptor signaling pathway|regulation of cell proliferation|SMAD protein complex assembly|transcription, DNA-dependent|transforming growth factor beta receptor complex assembly	nucleus	SMAD binding				0	all_cancers(60;4.04e-06)|all_lung(34;1.77e-07)|Lung NSC(34;2.09e-07)|all_epithelial(25;1.13e-05)|Ovarian(47;0.159)		Epithelial(26;3.2e-25)|all cancers(26;8.83e-23)|LUSC - Lung squamous cell carcinoma(53;0.00281)			CGGAGACGGAGATAGGGCAAC	0.602		NA											24	102					0	0	0	0
ZNF780A	284323	broad.mit.edu	37	19	40581529	40581529	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr19:40581529C>T	uc002omy.2	-	6	1045	c.820G>A	c.(820-822)GTA>ATA	p.V274I	ZNF780A_uc002omw.3_Intron|ZNF780A_uc002omz.2_Missense_Mutation_p.V274I|ZNF780A_uc010xvh.1_Missense_Mutation_p.V275I	NM_001010880	NP_001010880	O75290	Z780A_HUMAN	zinc finger protein 780A isoform b	274					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					TATGGTTTTACACCAGAATGA	0.388		NA											5	219					0	0	0	0
POLD1	5424	broad.mit.edu	37	19	50906777	50906777	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr19:50906777G>C	uc002psb.3	+	10	1221	c.1165G>C	c.(1165-1167)GAC>CAC	p.D389H	POLD1_uc002psc.3_Missense_Mutation_p.D389H|POLD1_uc010enx.2_RNA|POLD1_uc010eny.2_Missense_Mutation_p.D389H	NM_002691	NP_002682	P28340	DPOD1_HUMAN	DNA-directed DNA polymerase delta 1	389					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|DNA synthesis involved in DNA repair|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|response to UV|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	delta DNA polymerase complex|nucleoplasm|nucleotide-excision repair complex	3'-5'-exodeoxyribonuclease activity|chromatin binding|DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding|protein binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2		all_neural(266;0.0571)		OV - Ovarian serous cystadenocarcinoma(262;0.00794)|GBM - Glioblastoma multiforme(134;0.0195)		CCGTATCATGGACCCCGACGT	0.597		NA						DNA_polymerases_(catalytic_subunits)					19	138					0	0	0	0
LILRB4	11006	broad.mit.edu	37	19	55175317	55175317	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr19:55175317G>C	uc002qgp.2	+	3	538	c.176G>C	c.(175-177)CGT>CCT	p.R59P	LILRB4_uc002qgo.1_Missense_Mutation_p.R100P|LILRB4_uc002qgq.2_Missense_Mutation_p.R59P|LILRB4_uc010ers.1_5'UTR|LILRB4_uc002qgr.2_Missense_Mutation_p.R100P|LILRB4_uc010ert.2_Missense_Mutation_p.R100P|LILRB4_uc010eru.2_Missense_Mutation_p.R88P	NM_006847	NP_006838	Q8NHJ6	LIRB4_HUMAN	leukocyte immunoglobulin-like receptor,	59	Ig-like C2-type 1.|Extracellular (Potential).					integral to membrane|plasma membrane	antigen binding|receptor activity			ovary(3)	3				GBM - Glioblastoma multiforme(193;0.035)		CGGGAGTACCGTCTGGATAAA	0.587		NA											37	118					0	0	0	0
DPYSL5	56896	broad.mit.edu	37	2	27121496	27121496	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr2:27121496G>C	uc002rhu.3	+	2	287	c.129G>C	c.(127-129)ATG>ATC	p.M43I	DPYSL5_uc002rhv.3_Missense_Mutation_p.M43I	NM_020134	NP_064519	Q9BPU6	DPYL5_HUMAN	dihydropyrimidinase-like 5	43					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			ovary(2)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCGAGCTCATGATCCCTGGCG	0.577		NA											11	90					0	0	0	0
TSPYL6	388951	broad.mit.edu	37	2	54483229	54483229	+	Silent	SNP	C	C	T			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr2:54483229C>T	uc002rxr.2	-	1	181	c.60G>A	c.(58-60)CCG>CCA	p.P20P	ACYP2_uc002rxq.3_Intron	NM_001003937	NP_001003937	Q8N831	TSYL6_HUMAN	TSPY-like 6	20					nucleosome assembly	nucleus					0						GGCCCTGGTGCGGGTCTTCCA	0.622		NA											28	124					0	0	0	0
REG3G	130120	broad.mit.edu	37	2	79254230	79254230	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr2:79254230C>T	uc002snw.2	+	4	351	c.266C>T	c.(265-267)TCC>TTC	p.S89F	REG3G_uc002snx.2_Missense_Mutation_p.S89F|REG3G_uc010ffu.2_Intron	NM_198448	NP_940850	Q6UW15	REG3G_HUMAN	regenerating islet-derived 3 gamma precursor	89	C-type lectin.				acute-phase response	extracellular region	sugar binding				0						TCCTTCGTGTCCTCCCTGGTG	0.537		NA											21	106					0	0	0	0
REV1	51455	broad.mit.edu	37	2	100055565	100055565	+	Silent	SNP	C	C	T			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr2:100055565C>T	uc002tad.2	-	6	923	c.711G>A	c.(709-711)AAG>AAA	p.K237K	REV1_uc002tac.2_Silent_p.K237K|REV1_uc002tae.1_Silent_p.K216K	NM_016316	NP_057400	Q9UBZ9	REV1_HUMAN	REV1-like isoform 1	237					DNA replication|error-prone translesion synthesis|response to UV	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|magnesium ion binding|protein binding			ovary(2)	2						AATCCTGTGTCTTTAAGGCAC	0.512		NA						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					4	34					0	0	0	0
IL1R2	7850	broad.mit.edu	37	2	102636165	102636165	+	Silent	SNP	C	C	T			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr2:102636165C>T	uc002tbm.2	+	5	808	c.579C>T	c.(577-579)CTC>CTT	p.L193L	IL1R2_uc002tbn.2_Silent_p.L193L|IL1R2_uc002tbo.1_Silent_p.L193L	NM_004633	NP_004624	P27930	IL1R2_HUMAN	interleukin 1 receptor, type II precursor	193	Extracellular (Potential).|Ig-like C2-type 2.				immune response	integral to membrane|plasma membrane	interleukin-1, Type II, blocking receptor activity			ovary(1)|breast(1)	2					Anakinra(DB00026)	CTCACTTACTCGTACACGATG	0.418		NA											9	21					0	0	0	0
LCT	3938	broad.mit.edu	37	2	136566782	136566782	+	Silent	SNP	G	G	A			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr2:136566782G>A	uc002tuu.1	-	8	3146	c.3135C>T	c.(3133-3135)TAC>TAT	p.Y1045Y		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	1045	3.|Extracellular (Potential).|4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)		AAAAGTCTGCGTAGCTGTCAA	0.493		NA											28	55					0	0	0	0
MCM6	4175	broad.mit.edu	37	2	136610440	136610440	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr2:136610440T>C	uc002tuw.2	-	12	1748	c.1672A>G	c.(1672-1674)AGA>GGA	p.R558G		NM_005915	NP_005906	Q14566	MCM6_HUMAN	minichromosome maintenance complex component 6	558					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|identical protein binding				0				BRCA - Breast invasive adenocarcinoma(221;0.166)	Atorvastatin(DB01076)	TCCTCAATTCTTGAATGCAAA	0.368		NA											22	38					0	0	0	0
COL4A4	1286	broad.mit.edu	37	2	227966581	227966581	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr2:227966581C>A	uc010zlt.1	-	16	1629	c.975G>T	c.(973-975)AAG>AAT	p.K325N		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	325	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		GTACATTTACCTTTAATCCTG	0.318		NA											5	7					0.00116845	0.00131082	1	0
TBC1D20	128637	broad.mit.edu	37	20	420957	420957	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr20:420957C>T	uc002wds.2	-	6	841	c.703G>A	c.(703-705)GTC>ATC	p.V235I	TBC1D20_uc002wdv.2_Missense_Mutation_p.V58I|TBC1D20_uc002wdt.2_RNA|TBC1D20_uc002wdu.2_RNA	NM_144628	NP_653229	Q96BZ9	TBC20_HUMAN	TBC1 domain family, member 20	235	Rab-GAP TBC.				interspecies interaction between organisms	integral to membrane|intracellular	Rab GTPase activator activity			central_nervous_system(1)	1		all_epithelial(17;0.228)|Breast(17;0.231)				AACCGCACGACGTGCCTGAAG	0.557		NA											8	48					0	0	0	0
SIRPG	55423	broad.mit.edu	37	20	1629753	1629753	+	Silent	SNP	C	C	T			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr20:1629753C>T	uc002wfm.1	-	2	440	c.375G>A	c.(373-375)GGG>GGA	p.G125G	SIRPG_uc002wfn.1_Silent_p.G125G|SIRPG_uc002wfo.1_Silent_p.G125G	NM_018556	NP_061026	Q9P1W8	SIRPG_HUMAN	signal-regulatory protein gamma isoform 1	125	Extracellular (Potential).|Ig-like V-type.				blood coagulation|cell adhesion|cell junction assembly|cell-cell signaling|intracellular signal transduction|leukocyte migration|negative regulation of cell proliferation|positive regulation of cell proliferation|positive regulation of cell-cell adhesion|positive regulation of T cell activation	integral to membrane|intracellular|plasma membrane	protein binding			ovary(1)	1						TCTCAGGGCTCCCTTTTCGAA	0.498		NA											55	83					0	0	0	0
ZBP1	81030	broad.mit.edu	37	20	56191333	56191333	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr20:56191333C>T	uc002xyo.2	-	2	507	c.226G>A	c.(226-228)GAG>AAG	p.E76K	ZBP1_uc010gjm.2_Missense_Mutation_p.E76K|ZBP1_uc002xyp.2_Intron|ZBP1_uc010zzn.1_Missense_Mutation_p.E76K	NM_030776	NP_110403	Q9H171	ZBP1_HUMAN	Z-DNA binding protein 1 isoform a	76						cytoplasm|nucleus	double-stranded RNA adenosine deaminase activity|left-handed Z-DNA binding|RNA binding			ovary(2)	2	Lung NSC(12;0.000545)|all_lung(29;0.00195)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;7.87e-13)|Epithelial(14;3.26e-09)|all cancers(14;3.62e-08)			GCAGGACCCTCGCCTTCAGGA	0.527		NA											15	43					0	0	0	0
MOV10L1	54456	broad.mit.edu	37	22	50546633	50546633	+	Missense_Mutation	SNP	G	G	A	rs147590689		TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr22:50546633G>A	uc003bjj.2	+	4	594	c.511G>A	c.(511-513)GAA>AAA	p.E171K	MOV10L1_uc003bjk.3_Missense_Mutation_p.E171K|MOV10L1_uc011arp.1_Missense_Mutation_p.E151K|MOV10L1_uc010han.2_Missense_Mutation_p.E151K	NM_018995	NP_061868	Q9BXT6	M10L1_HUMAN	MOV10-like 1 isoform 1	171					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding			ovary(2)|skin(1)	3		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		GTGGAGCAGCGAAGCCACCTC	0.602		NA											7	19					0	0	0	0
BSN	8927	broad.mit.edu	37	3	49700618	49700618	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr3:49700618G>T	uc003cxe.3	+	7	11141	c.11027G>T	c.(11026-11028)CGC>CTC	p.R3676L		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	3676					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		GACCTGGGTCGCCATGAGGCC	0.667		NA											8	26					0.00307968	0.00339783	1	0
KLHL24	54800	broad.mit.edu	37	3	183368865	183368865	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr3:183368865G>A	uc003flv.2	+	3	1016	c.721G>A	c.(721-723)GTT>ATT	p.V241I	KLHL24_uc003flw.2_Missense_Mutation_p.V241I|KLHL24_uc003flx.2_Missense_Mutation_p.V241I	NM_017644	NP_060114	Q6TFL4	KLH24_HUMAN	DRE1 protein	241	BACK.					axon|cytoplasm|perikaryon				ovary(1)	1	all_cancers(143;2.88e-10)|Ovarian(172;0.0303)		all cancers(12;1.43e-42)|Epithelial(37;1.73e-36)|OV - Ovarian serous cystadenocarcinoma(80;8.75e-22)			CTATCGTGCCGTTGATCTGAG	0.418		NA											13	53					0	0	0	0
GABRA2	2555	broad.mit.edu	37	4	46334667	46334667	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr4:46334667C>T	uc003gxc.3	-	3	893	c.220G>A	c.(220-222)GTG>ATG	p.V74M	GABRA2_uc010igc.2_Missense_Mutation_p.V74M|GABRA2_uc011bzc.1_Intron|GABRA2_uc003gxe.2_Missense_Mutation_p.V74M	NM_001114175	NP_001107647	P47869	GBRA2_HUMAN	gamma-aminobutyric acid A receptor, alpha 2	74	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|neurotransmitter transport|regulation of neurotransmitter levels	cell junction|chloride channel complex|integral to synaptic vesicle membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|skin(2)	4					Alprazolam(DB00404)|Bromazepam(DB01558)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Fludiazepam(DB01567)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	AAACTGGTCACGTAGATGTTA	0.343		NA											14	34					0	0	0	0
LRRC66	339977	broad.mit.edu	37	4	52862054	52862054	+	Silent	SNP	C	C	T			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr4:52862054C>T	uc003gzi.2	-	4	1147	c.1134G>A	c.(1132-1134)GCG>GCA	p.A378A		NM_001024611	NP_001019782	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	378	Helical; (Potential).					integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3						ACAGGCACACCGCCAGAGCCA	0.562		NA											32	59					0	0	0	0
PCDH10	57575	broad.mit.edu	37	4	134071659	134071659	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr4:134071659T>C	uc003iha.2	+	1	1190	c.364T>C	c.(364-366)TTC>CTC	p.F122L	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Missense_Mutation_p.F122L	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	122	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		CCCCCCCTCTTTCCCGGAGCC	0.612		NA											16	86					0	0	0	0
NPY5R	4889	broad.mit.edu	37	4	164271702	164271702	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr4:164271702T>C	uc003iqn.2	+	4	459	c.277T>C	c.(277-279)TTT>CTT	p.F93L		NM_006174	NP_006165	Q15761	NPY5R_HUMAN	neuropeptide Y receptor Y5	93	Helical; Name=2; (Potential).				cardiac left ventricle morphogenesis|outflow tract morphogenesis	integral to plasma membrane				lung(6)|skin(1)	7	all_hematologic(180;0.166)	Prostate(90;0.109)				GGTTGTGCTGTTTTGCTCACC	0.403		NA											66	148					0	0	0	0
MTRR	4552	broad.mit.edu	37	5	7873624	7873624	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr5:7873624C>T	uc003jed.2	+	3	379	c.349C>T	c.(349-351)CGG>TGG	p.R117W	MTRR_uc010itn.1_Intron|MTRR_uc003jee.3_Missense_Mutation_p.R90W|MTRR_uc003jef.3_RNA|MTRR_uc003jeg.3_Intron|MTRR_uc010ito.2_RNA	NM_024010	NP_076915	Q9UBK8	MTRR_HUMAN	methionine synthase reductase isoform 2	117	Flavodoxin-like.				methionine biosynthetic process	cytosol	[methionine synthase] reductase activity|flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding			ovary(1)	1					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)|L-Methionine(DB00134)	TGCTCACCTGCGGTATGGGTT	0.448		NA											17	69					0	0	0	0
EGFLAM	133584	broad.mit.edu	37	5	38370532	38370532	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr5:38370532G>A	uc003jlc.1	+	6	1004	c.680G>A	c.(679-681)CGC>CAC	p.R227H	EGFLAM_uc003jlb.1_Missense_Mutation_p.R227H	NM_152403	NP_689616	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G	227	Fibronectin type-III 2.					cell junction|proteinaceous extracellular matrix|synapse				pancreas(3)|skin(3)|ovary(1)	7	all_lung(31;0.000385)					CCCAGCCCCCGCAGCTGGCCC	0.577		NA											5	21					0	0	0	0
RNF14	9604	broad.mit.edu	37	5	141359811	141359811	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr5:141359811C>G	uc003lly.2	+	5	997	c.958C>G	c.(958-960)CAG>GAG	p.Q320E	RNF14_uc003llz.2_Missense_Mutation_p.Q320E|RNF14_uc003lma.2_Missense_Mutation_p.Q320E|RNF14_uc003lmb.2_Missense_Mutation_p.Q194E|RNF14_uc003lmc.2_Missense_Mutation_p.Q320E|RNF14_uc011dbg.1_Missense_Mutation_p.Q144E|RNF14_uc011dbh.1_Intron|RNF14_uc003lmd.2_Missense_Mutation_p.Q320E	NM_183399	NP_899646	Q9UBS8	RNF14_HUMAN	ring finger protein 14 isoform 1	320	IBR-type.				androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|protein ubiquitination|regulation of androgen receptor signaling pathway|regulation of transcription from RNA polymerase II promoter|response to estradiol stimulus|transcription, DNA-dependent	cytoplasm|nucleus	androgen receptor binding|small conjugating protein ligase activity|transcription coactivator activity|zinc ion binding				0		all_hematologic(541;0.0536)|Ovarian(839;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.0407)		GCCTGTGATGCAGGAACCTGG	0.567		NA											59	31					0	0	0	0
NSD1	64324	broad.mit.edu	37	5	176709563	176709563	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr5:176709563A>G	uc003mfr.3	+	19	6128	c.5990A>G	c.(5989-5991)TAT>TGT	p.Y1997C	NSD1_uc003mft.3_Missense_Mutation_p.Y1728C|NSD1_uc011dfx.1_Missense_Mutation_p.Y1645C	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1997	S-adenosyl-L-methionine binding.|SET.		Y -> C (in WES).		negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		ACTAATTTCTATATGCTCACC	0.373		NA	T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			50	21					0	0	0	0
HIST1H4E	8367	broad.mit.edu	37	6	26204885	26204885	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr6:26204885G>A	uc003ngy.2	+	1	13	c.13G>A	c.(13-15)GGC>AGC	p.G5S		NM_003545	NP_003536	P62805	H4_HUMAN	histone cluster 1, H4e	5					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)	1		all_hematologic(11;0.196)				GTCTGGTCGCGGCAAAGGCGG	0.517		NA											30	63					0	0	0	0
ABCF1	23	broad.mit.edu	37	6	30546133	30546133	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr6:30546133C>A	uc003nql.2	+	5	447	c.352C>A	c.(352-354)CCA>ACA	p.P118T	ABCF1_uc003nqk.2_Missense_Mutation_p.P119T|ABCF1_uc003nqm.2_Missense_Mutation_p.P118T|ABCF1_uc010jsb.2_Intron	NM_001025091	NP_001020262	Q8NE71	ABCF1_HUMAN	ATP-binding cassette, sub-family F, member 1	118					inflammatory response|translational initiation	nuclear envelope|nuclear envelope|nucleoplasm|nucleoplasm|polysomal ribosome	ATP binding|ATP binding|ATPase activity|protein binding|ribosome binding|translation activator activity|translation factor activity, nucleic acid binding			ovary(2)	2						AGTACCCGCCCCAAAACCCCG	0.498		NA											4	78					0.00909568	0.00979253	1	0
AKD1	221264	broad.mit.edu	37	6	109962806	109962806	+	Missense_Mutation	SNP	C	C	T	rs148448147	byFrequency	TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr6:109962806C>T	uc003ptn.2	-	10	925	c.848G>A	c.(847-849)CGA>CAA	p.R283Q	AKD1_uc003ptr.3_Missense_Mutation_p.R283Q	NM_001145128	NP_001138600	Q5TCS8	AKD1_HUMAN	adenylate kinase domain containing 1 isoform 1	283					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|nucleoside-triphosphatase activity			ovary(1)	1						ATATTTAAGTCGATCCATAAC	0.348		NA											18	30					0	0	0	0
TIAM2	26230	broad.mit.edu	37	6	155485661	155485661	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr6:155485661C>A	uc003qqb.2	+	10	3414	c.2141C>A	c.(2140-2142)GCA>GAA	p.A714E	TIAM2_uc003qqe.2_Missense_Mutation_p.A714E|TIAM2_uc010kjj.2_Missense_Mutation_p.A247E|TIAM2_uc003qqf.2_Missense_Mutation_p.A66E|TIAM2_uc011efl.1_Missense_Mutation_p.A26E|TIAM2_uc003qqg.2_Missense_Mutation_p.A26E	NM_012454	NP_036586	Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	714					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			ovary(3)|breast(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		AGTCTCCTTGCAGCCGCCAGC	0.552		NA											80	148					5.82e-33	7.13e-33	1	0
INTS1	26173	broad.mit.edu	37	7	1523641	1523641	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr7:1523641A>G	uc003skn.2	-	25	3528	c.3427T>C	c.(3427-3429)TGG>CGG	p.W1143R	INTS1_uc003skp.1_Missense_Mutation_p.W490R	NM_001080453	NP_001073922	Q8N201	INT1_HUMAN	integrator complex subunit 1	1143					snRNA processing	integral to membrane|integrator complex|nuclear membrane					0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		GCCCTCACCCAGCTGTAGACC	0.687		NA											14	55					0	0	0	0
INTS1	26173	broad.mit.edu	37	7	1523644	1523644	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr7:1523644T>C	uc003skn.2	-	25	3525	c.3424A>G	c.(3424-3426)AGC>GGC	p.S1142G	INTS1_uc003skp.1_Missense_Mutation_p.S489G	NM_001080453	NP_001073922	Q8N201	INT1_HUMAN	integrator complex subunit 1	1142					snRNA processing	integral to membrane|integrator complex|nuclear membrane					0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		CTCACCCAGCTGTAGACCTCC	0.687		NA											14	55					0	0	0	0
AHR	196	broad.mit.edu	37	7	17382646	17382646	+	Missense_Mutation	SNP	A	A	T	rs146912085		TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr7:17382646A>T	uc011jxz.1	+	11	3118	c.2505A>T	c.(2503-2505)GAA>GAT	p.E835D	AHR_uc003stt.3_RNA	NM_001621	NP_001612	P35869	AHR_HUMAN	aryl hydrocarbon receptor precursor	835				LNETYPAELNNINNTQTTTHLQPLHHPSEARPFPDLTSSGF L -> FK (in Ref. 1; BAA03857).	apoptosis|blood vessel development|cell cycle|regulation of B cell proliferation|response to stress|transcription from RNA polymerase II promoter|xenobiotic metabolic process	cytosolic aryl hydrocarbon receptor complex|transcription factor complex	Hsp90 protein binding|ligand-dependent nuclear receptor activity|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			urinary_tract(1)|kidney(1)|pancreas(1)	3	Lung NSC(10;0.0392)|all_lung(11;0.0754)					ATCCGTCAGAAGCCAGACCTT	0.373		NA											77	87					0	0	0	0
HDAC9	9734	broad.mit.edu	37	7	18975526	18975526	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr7:18975526T>G	uc003suh.2	+	22	2930	c.2889T>G	c.(2887-2889)GAT>GAG	p.D963E	HDAC9_uc003sue.2_Missense_Mutation_p.D963E|HDAC9_uc003sui.2_Missense_Mutation_p.D966E|HDAC9_uc003suj.2_Missense_Mutation_p.D922E|HDAC9_uc003suk.2_Missense_Mutation_p.D211E	NM_058176	NP_478056	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9 isoform 1	963	Histone deacetylase.				B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			lung(2)|central_nervous_system(2)|kidney(1)	5	all_lung(11;0.187)				Valproic Acid(DB00313)	CCATCTGTGATGCATCAGAAG	0.438		NA											36	96					0	0	0	0
KLHL7	55975	broad.mit.edu	37	7	23213806	23213806	+	Silent	SNP	C	C	T	rs142565112		TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr7:23213806C>T	uc003svs.3	+	11	1943	c.1650C>T	c.(1648-1650)ACC>ACT	p.T550T	KLHL7_uc003svr.3_Silent_p.T528T|KLHL7_uc011jys.1_Silent_p.T474T|KLHL7_uc011jyt.1_Silent_p.T325T|KLHL7_uc003svt.2_Silent_p.T502T|KLHL7_uc011jyv.1_Silent_p.T280T	NM_001031710	NP_001026880	Q8IXQ5	KLHL7_HUMAN	kelch-like 7 isoform 1	550	Kelch 6.					Golgi apparatus|nucleolus|plasma membrane					0						AATATAATACCGAAACAGACA	0.423		NA											27	46					0	0	0	0
SRRT	51593	broad.mit.edu	37	7	100484575	100484575	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr7:100484575G>A	uc003uwy.2	+	15	2075	c.1807G>A	c.(1807-1809)GAG>AAG	p.E603K	SRRT_uc010lhl.1_Missense_Mutation_p.E602K|SRRT_uc003uxa.2_Missense_Mutation_p.E602K|SRRT_uc003uwz.2_Missense_Mutation_p.E603K	NM_015908	NP_056992	Q9BXP5	SRRT_HUMAN	arsenate resistance protein 2 isoform a	603					cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			ovary(2)	2						GGAGCGGGATGAGAAGTTGAT	0.647		NA											30	196					0	0	0	0
CUX1	1523	broad.mit.edu	37	7	101844779	101844779	+	Silent	SNP	C	C	T	rs150235372		TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr7:101844779C>T	uc003uyx.3	+	18	2240	c.2202C>T	c.(2200-2202)TCC>TCT	p.S734S	CUX1_uc003uys.3_Silent_p.S745S|CUX1_uc003uyt.2_Intron|CUX1_uc011kkn.1_Intron|CUX1_uc003uyw.2_Intron|CUX1_uc003uyv.2_Intron|CUX1_uc003uyu.2_Intron	NM_181552	NP_853530	P39880	CUX1_HUMAN	cut-like homeobox 1 isoform a	734					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.S734S(1)		ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8						CACCACTGTCCCAGAGTGACA	0.632		NA											22	318					0	0	0	0
TRPS1	7227	broad.mit.edu	37	8	116430580	116430580	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr8:116430580C>G	uc003ynz.2	-	5	3221	c.2762G>C	c.(2761-2763)GGC>GCC	p.G921A	TRPS1_uc011lhy.1_Missense_Mutation_p.G925A|TRPS1_uc003yny.2_Missense_Mutation_p.G934A|TRPS1_uc010mcy.2_Missense_Mutation_p.G921A	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	921					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			CTGGTAGAGGCCACACGCGTT	0.483		NA							Langer-Giedion_syndrome				137	31					0	0	0	0
FLJ43860	389690	broad.mit.edu	37	8	142445304	142445304	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr8:142445304G>A	uc003ywi.2	-	29	3682	c.3601C>T	c.(3601-3603)CGG>TGG	p.R1201W	FLJ43860_uc011ljs.1_RNA|FLJ43860_uc010meu.1_RNA	NM_207414	NP_997297	Q6ZUA9	Q6ZUA9_HUMAN	hypothetical protein LOC389690	1201							binding				0	all_cancers(97;7.79e-15)|all_epithelial(106;4.52e-13)|Lung NSC(106;2.07e-05)|all_lung(105;2.89e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			TGCAGTAGCCGCCAGCGGAGC	0.667		NA											56	18					0	0	0	0
ADAMTSL1	92949	broad.mit.edu	37	9	18777750	18777750	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr9:18777750C>A	uc003zne.3	+	19	3650	c.3523C>A	c.(3523-3525)CAG>AAG	p.Q1175K		NM_001040272	NP_001035362	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1 isoform 4 precursor	1175	Ig-like C2-type 2.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)	5				GBM - Glioblastoma multiforme(50;1.29e-17)		AGCGGCCCAGCAGCTCTCAGC	0.692		NA											13	15					0.00136819	0.00152212	1	0
CDKN2A	1029	broad.mit.edu	37	9	21971186	21971186	+	Nonsense_Mutation	SNP	G	G	A	rs121913387		TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr9:21971186G>A	uc003zpk.2	-	2	384	c.172C>T	c.(172-174)CGA>TGA	p.R58*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.P113L	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	58	ANK 2.				cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.R58*(68)|p.?(14)|p.M53_R58del(3)|p.R58fs*59(2)|p.M54fs*61(2)|p.R58fs*89(1)|p.R58R(1)|p.V28_V51del(1)|p.A57_R58>V*(1)|p.R58fs*61(1)|p.R58fs*62(1)|p.G55fs*86(1)|p.R58Q(1)|p.P113L(1)|p.A57fs*85(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TCCGCCACTCGGGCGCTGCCC	0.677		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			8	6					0	0	0	0
GDA	9615	broad.mit.edu	37	9	74834409	74834409	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr9:74834409T>A	uc004aiq.2	+	6	776	c.593T>A	c.(592-594)ATG>AAG	p.M198K	GDA_uc011lse.1_Missense_Mutation_p.M124K|GDA_uc011lsf.1_Missense_Mutation_p.M124K|GDA_uc004air.2_Missense_Mutation_p.M198K|GDA_uc010mow.1_RNA|GDA_uc004ais.2_Missense_Mutation_p.M156K|GDA_uc004ait.1_Missense_Mutation_p.M124K	NM_004293	NP_004284	Q9Y2T3	GUAD_HUMAN	guanine deaminase	198					nervous system development|purine base metabolic process|purine nucleotide catabolic process	cytosol	guanine deaminase activity|zinc ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5		Myeloproliferative disorder(762;0.0122)		Lung(182;0.0583)		GTGTCAGAAATGCTCCAAAAG	0.284		NA											10	15					0	0	0	0
DOLK	22845	broad.mit.edu	37	9	131708963	131708963	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr9:131708963T>G	uc004bwr.2	-	1	1050	c.620A>C	c.(619-621)CAG>CCG	p.Q207P	NUP188_uc004bws.1_5'Flank|NUP188_uc004bwq.1_Intron	NM_014908	NP_055723	Q9UPQ8	DOLK_HUMAN	dolichol kinase	207	Helical; (Potential).				dolichyl diphosphate biosynthetic process|dolichyl monophosphate biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to endoplasmic reticulum membrane|membrane fraction	dolichol kinase activity				0						CTTGATGAGCTGGTTGAGGAC	0.542		NA											40	35					0	0	0	0
DMD	1756	broad.mit.edu	37	X	31838157	31838157	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chrX:31838157C>T	uc004dda.1	-	50	7488	c.7244G>A	c.(7243-7245)CGT>CAT	p.R2415H	DMD_uc004dcr.1_5'UTR|DMD_uc004dcs.1_5'UTR|DMD_uc004dct.1_5'UTR|DMD_uc004dcu.1_5'UTR|DMD_uc004dcv.1_5'UTR|DMD_uc004dcw.2_Missense_Mutation_p.R1071H|DMD_uc004dcx.2_Missense_Mutation_p.R1074H|DMD_uc004dcz.2_Missense_Mutation_p.R2292H|DMD_uc004dcy.1_Missense_Mutation_p.R2411H|DMD_uc004ddb.1_Missense_Mutation_p.R2407H|DMD_uc004ddd.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	2415					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TTGAAGTAAACGGTTTACCGC	0.428		NA											20	12					0	0	0	0
PCDH11X	27328	broad.mit.edu	37	X	91873697	91873697	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chrX:91873697C>A	uc004efk.1	+	7	4647	c.3802C>A	c.(3802-3804)CAT>AAT	p.H1268N	PCDH11X_uc004efl.1_Missense_Mutation_p.H1258N|PCDH11X_uc004efo.1_Missense_Mutation_p.H1231N|PCDH11X_uc010nmv.1_3'UTR|PCDH11X_uc004efm.1_Missense_Mutation_p.H1260N|PCDH11X_uc004efn.1_Missense_Mutation_p.H1250N	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	1268	Cytoplasmic (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						TATTGCCCTCCATCGTAGTCA	0.562		NA											73	83					2.82e-13	3.36e-13	1	0
CHRDL1	91851	broad.mit.edu	37	X	109943927	109943927	+	Silent	SNP	T	T	C			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chrX:109943927T>C	uc004eou.3	-	7	913	c.564A>G	c.(562-564)GAA>GAG	p.E188E	CHRDL1_uc004eov.2_Silent_p.E182E|CHRDL1_uc004eow.2_Silent_p.E187E|CHRDL1_uc010nps.2_Silent_p.E187E|CHRDL1_uc004eot.2_Silent_p.E108E|CHRDL1_uc011mss.1_Silent_p.E102E	NM_001143981	NP_001137453	Q9BU40	CRDL1_HUMAN	chordin-like 1 isoform 1 precursor	181					BMP signaling pathway|cell differentiation|nervous system development|ossification	extracellular region					0						CATCAGAATGTTCCCATGACA	0.403		NA											12	28					0	0	0	0
ARHGAP36	158763	broad.mit.edu	37	X	130218231	130218231	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chrX:130218231G>T	uc004evz.2	+	5	943	c.598G>T	c.(598-600)GCC>TCC	p.A200S	ARHGAP36_uc004ewa.2_Missense_Mutation_p.A188S|ARHGAP36_uc004ewb.2_Missense_Mutation_p.A169S|ARHGAP36_uc004ewc.2_Missense_Mutation_p.A64S	NM_144967	NP_659404	Q6ZRI8	RHG36_HUMAN	hypothetical protein LOC158763 precursor	200					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)	3						GGAAGACGGAGCCCTGCTGCT	0.463		NA											13	9					1.58e-08	1.86e-08	1	0
IL9R	3581	broad.mit.edu	37	X	155233408	155233408	+	Silent	SNP	A	A	G			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chrX:155233408A>G	uc004fnv.1	+	4	500	c.321A>G	c.(319-321)CCA>CCG	p.P107P	IL9R_uc010nvn.2_Silent_p.P86P|IL9R_uc004fnu.1_Missense_Mutation_p.H152R	NM_002186	NP_002177	Q01113	IL9R_HUMAN	interleukin 9 receptor precursor	107	Extracellular (Potential).				cell proliferation	extracellular space|integral to plasma membrane	interleukin-9 receptor activity				0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					TCGTGCTGCCACCTGAGGCAG	0.607		NA											9	19					0	0	0	0
CHD5	26038	broad.mit.edu	37	1	6202630	6202632	+	In_Frame_Del	DEL	GAT	GAT	-			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr1:6202630_6202632delGAT	uc001amb.1	-	14	2177_2179	c.2077_2079delATC	c.(2077-2079)ATCdel	p.I693del	CHD5_uc001ama.1_RNA|CHD5_uc001amc.1_RNA	NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	693					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		CTGTGGAGTCGATGTACCATGGC	0.616		NA											18	72	---	---	---	---	NA	NA	NA	NA
SPOCD1	90853	broad.mit.edu	37	1	32263807	32263824	+	Splice_Site	DEL	CCCTTTTCTCCTCCTGGT	CCCTTTTCTCCTCCTGGT	-			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr1:32263807_32263824delCCCTTTTCTCCTCCTGGT	uc001bts.1	-	9	2203	c.2145_splice	c.e9+1	p.R715_splice	SPOCD1_uc001btt.2_Splice_Site_p.R21_splice|SPOCD1_uc001btu.2_Splice_Site_p.R715_splice|SPOCD1_uc001btv.2_Splice_Site_p.R208_splice|SPOCD1_uc001btw.1_Splice_Site_p.R59_splice	NM_144569	NP_653170	Q6ZMY3	SPOC1_HUMAN	SPOC domain containing 1						transcription, DNA-dependent					ovary(5)|breast(1)	6		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)|Ovarian(437;0.199)		STAD - Stomach adenocarcinoma(196;0.18)		TCAGCACTCACCCTTTTCTCCTCCTGGTCCCGCCAGCG	0.385		NA											8	64	---	---	---	---	NA	NA	NA	NA
MKI67	4288	broad.mit.edu	37	10	129902204	129902205	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr10:129902204_129902205delTG	uc001lke.2	-	13	8094_8095	c.7899_7900delCA	c.(7897-7902)CACAAAfs	p.H2633fs	MKI67_uc001lkf.2_Frame_Shift_Del_p.H2273fs|MKI67_uc009yav.1_Frame_Shift_Del_p.H2208fs|MKI67_uc009yaw.1_Frame_Shift_Del_p.H1783fs	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	2633_2634	14.|16 X 122 AA approximate repeats.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				GCTGGTTCTTTGTGTGTGTGTG	0.5		NA											7	110	---	---	---	---	NA	NA	NA	NA
FOLR1	2348	broad.mit.edu	37	11	71903251	71903253	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr11:71903251_71903253delCTT	uc001orz.1	+	3	172_174	c.34_36delCTT	c.(34-36)CTTdel	p.L13del	FOLR1_uc001osa.1_In_Frame_Del_p.L13del|FOLR1_uc001osb.1_In_Frame_Del_p.L13del|FOLR1_uc001osc.1_In_Frame_Del_p.L13del|FOLR1_uc001osd.1_In_Frame_Del_p.L13del	NM_016724	NP_057936	P15328	FOLR1_HUMAN	folate receptor 1 precursor	13					cell death|folic acid transport|receptor-mediated endocytosis	anchored to membrane|extracellular region|integral to plasma membrane|membrane fraction	folic acid binding|receptor activity			ovary(1)	1						GCTGCTGCTCCTTCTAGTGTGGG	0.547		NA											37	99	---	---	---	---	NA	NA	NA	NA
PPL	5493	broad.mit.edu	37	16	4945271	4945272	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr16:4945271_4945272insT	uc002cyd.1	-	11	1322_1323	c.1232_1233insA	c.(1231-1233)GAGfs	p.E411fs		NM_002705	NP_002696	O60437	PEPL_HUMAN	periplakin	411	Spectrin 2.				keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(4)|central_nervous_system(1)|skin(1)	6						CCTGCTCCCCCTCAAAGTCACA	0.495		NA											14	39	---	---	---	---	NA	NA	NA	NA
CCDC124	115098	broad.mit.edu	37	19	18053527	18053529	+	In_Frame_Del	DEL	GGA	GGA	-			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr19:18053527_18053529delGGA	uc010xpz.1	+	3	267_269	c.222_224delGGA	c.(220-225)CTGGAG>CTG	p.E77del	CCDC124_uc002nhs.2_In_Frame_Del_p.E77del	NM_001136203	NP_001129675	Q96CT7	CC124_HUMAN	coiled-coil domain containing 124	77	Potential.						DNA binding				0						AGCGCCTACTGGAGGAGGAGGAC	0.675		NA											2	4	---	---	---	---	NA	NA	NA	NA
ZNF420	147923	broad.mit.edu	37	19	37619779	37619780	+	Frame_Shift_Ins	INS	-	-	T	rs142983916	by1000genomes	TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr19:37619779_37619780insT	uc002ofl.2	+	5	2101_2102	c.1886_1887insT	c.(1885-1887)CATfs	p.H629fs		NM_144689	NP_653290	Q8TAQ5	ZN420_HUMAN	zinc finger protein 420	629	C2H2-type 18.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CAGAGTTCACATCTTTCTCGGC	0.426		NA											38	35	---	---	---	---	NA	NA	NA	NA
RGPD4	285190	broad.mit.edu	37	2	108478175	108478175	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr2:108478175delA	uc010ywk.1	+	15	2266	c.2184delA	c.(2182-2184)TCAfs	p.S728fs	RGPD4_uc002tdu.2_5'UTR|RGPD4_uc010ywl.1_RNA	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	728					intracellular transport		binding			skin(2)	2						ACAGTGATTCAAATCTTTCAG	0.373		NA											8	45	---	---	---	---	NA	NA	NA	NA
NCL	4691	broad.mit.edu	37	2	232326373	232326378	+	In_Frame_Del	DEL	TCCTCG	TCCTCG	-	rs151176710	byFrequency	TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr2:232326373_232326378delTCCTCG	uc002vru.2	-	3	627_632	c.486_491delCGAGGA	c.(484-492)GACGAGGAT>GAT	p.162_164DED>D	SNORD82_uc010fxw.1_5'Flank	NM_005381	NP_005372	P19338	NUCL_HUMAN	nucleolin	162_164	Asp/Glu-rich (acidic).				angiogenesis	cell cortex|nucleolus|ribonucleoprotein complex	nucleotide binding|protein C-terminus binding|RNA binding|telomeric DNA binding			ovary(2)|pancreas(1)	3		Ovarian(221;1.34e-05)|Renal(207;0.0112)|Lung NSC(271;0.0339)|all_lung(227;0.0616)|all_hematologic(139;0.0748)|Hepatocellular(293;0.137)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.65e-111)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.014)|COAD - Colon adenocarcinoma(134;0.141)|STAD - Stomach adenocarcinoma(1183;0.18)		ttcatcctcatcctcgtcctcgtcat	0.262		NA											22	44	---	---	---	---	NA	NA	NA	NA
FIBCD1	84929	broad.mit.edu	37	9	133805423	133805423	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CR-5247-01A-01D-2012-08	TCGA-CR-5247-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3b5b07b4-29ef-4a55-b6ab-93352613f631	0a609d02-a7e6-4a46-8d4e-48923c54d349	g.chr9:133805423delC	uc004bzz.2	-	2	328	c.83delG	c.(82-84)TGCfs	p.C28fs	FIBCD1_uc011mcc.1_Frame_Shift_Del_p.C28fs|FIBCD1_uc011mcd.1_Frame_Shift_Del_p.C36fs	NM_032843	NP_116232	Q8N539	FBCD1_HUMAN	fibrinogen C domain containing 1	28	Cytoplasmic (Potential).				signal transduction	extracellular space|integral to membrane	chitin binding|metal ion binding|receptor binding				0	all_hematologic(7;0.0028)			OV - Ovarian serous cystadenocarcinoma(145;3.52e-05)|Epithelial(140;0.00019)		CACGTAGCCGCAGCTCGGCCG	0.682		NA											2	4	---	---	---	---	NA	NA	NA	NA