Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
DVL1	1855	broad.mit.edu	37	1	1273937	1273937	+	Missense_Mutation	SNP	A	A	C			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr1:1273937A>C	uc001aer.3	-	12	1276	c.1229T>G	c.(1228-1230)ATG>AGG	p.M410R	DVL1_uc002quu.2_Missense_Mutation_p.M152R|DVL1_uc009vka.2_Missense_Mutation_p.M93R|DVL1_uc001aeu.1_Missense_Mutation_p.M169R	NM_004421	NP_004412	O14640	DVL1_HUMAN	dishevelled 1	435	DEP.				canonical Wnt receptor signaling pathway|dendrite morphogenesis|intracellular signal transduction|negative regulation of protein binding|negative regulation of protein kinase activity|neural tube development|neuromuscular junction development|neurotransmitter secretion|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway|protein localization to nucleus|receptor clustering|transcription from RNA polymerase II promoter|Wnt receptor signaling pathway, planar cell polarity pathway	cytoplasmic membrane-bounded vesicle|cytosol|plasma membrane|synapse|synaptosome	frizzled binding|identical protein binding|protein kinase binding|signal transducer activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;2.83e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		CTTGAGCCACATGCGGTCGCG	0.672		NA											10	41					0	0	0	0
DNAJC11	55735	broad.mit.edu	37	1	6699997	6699997	+	Silent	SNP	C	C	G			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr1:6699997C>G	uc001aof.2	-	11	1324	c.1218G>C	c.(1216-1218)CTG>CTC	p.L406L	DNAJC11_uc010nzt.1_Intron|DNAJC11_uc001aog.2_Intron|DNAJC11_uc010nzu.1_Silent_p.L316L	NM_018198	NP_060668	Q9NVH1	DJC11_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 11	406					protein folding		heat shock protein binding|unfolded protein binding			ovary(1)|skin(1)	2	Ovarian(185;0.0265)|all_lung(157;0.154)	all_cancers(23;1.97e-27)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;2.34e-07)|COAD - Colon adenocarcinoma(227;2.05e-05)|Kidney(185;7.67e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000639)|KIRC - Kidney renal clear cell carcinoma(229;0.00128)|STAD - Stomach adenocarcinoma(132;0.00179)|READ - Rectum adenocarcinoma(331;0.0649)		GTTTGATGATCAGACGGTGCA	0.393		NA											6	27					0	0	0	0
UBIAD1	29914	broad.mit.edu	37	1	11345928	11345928	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr1:11345928G>A	uc001asg.2	+	2	1091	c.757G>A	c.(757-759)GGC>AGC	p.G253S		NM_013319	NP_037451	Q9Y5Z9	UBIA1_HUMAN	UbiA prenyltransferase domain containing 1	253	Helical; (Potential).				menaquinone biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrion|nucleus	prenyltransferase activity				0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000818)|all_lung(284;0.00105)|Colorectal(325;0.0062)|Breast(348;0.012)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.52e-06)|COAD - Colon adenocarcinoma(227;0.000254)|BRCA - Breast invasive adenocarcinoma(304;0.000299)|Kidney(185;0.000754)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00727)|READ - Rectum adenocarcinoma(331;0.0487)		CATCCTCATCGGCCCCACGTT	0.607		NA											13	93					0	0	0	0
HSPG2	3339	broad.mit.edu	37	1	22169810	22169810	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr1:22169810G>A	uc001bfj.2	-	66	8778	c.8738C>T	c.(8737-8739)TCC>TTC	p.S2913F	HSPG2_uc009vqd.2_Missense_Mutation_p.S2914F	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	2913	Ig-like C2-type 14.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	TCCTGGGCTGGAGGGCTCAAT	0.632		NA											10	46					0	0	0	0
CDC7	8317	broad.mit.edu	37	1	91978847	91978847	+	Missense_Mutation	SNP	C	C	A			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr1:91978847C>A	uc001doe.2	+	7	970	c.805C>A	c.(805-807)CAA>AAA	p.Q269K	CDC7_uc001dof.2_Missense_Mutation_p.Q269K|CDC7_uc010osw.1_Missense_Mutation_p.Q241K|CDC7_uc009wdc.2_Missense_Mutation_p.Q269K|CDC7_uc009wdd.2_5'Flank	NM_003503	NP_003494	O00311	CDC7_HUMAN	cell division cycle 7	269	Protein kinase.				cell cycle checkpoint|cell division|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|positive regulation of cell proliferation|regulation of S phase	cytoplasm|nucleoplasm	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			stomach(2)|large_intestine(1)|ovary(1)|central_nervous_system(1)	5		all_lung(203;0.0165)|Lung NSC(277;0.0562)		all cancers(265;0.00108)|Epithelial(280;0.0184)|KIRC - Kidney renal clear cell carcinoma(1967;0.124)		TCAGATTAAACAAGGAAAAGA	0.403		NA											4	29					1.24e-05	2.91e-05	1	0
LAD1	3898	broad.mit.edu	37	1	201358343	201358343	+	Missense_Mutation	SNP	C	C	T	rs138881525		TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr1:201358343C>T	uc001gwm.2	-	2	362	c.127G>A	c.(127-129)GAT>AAT	p.D43N	LAD1_uc009wzu.1_Missense_Mutation_p.D65N	NM_005558	NP_005549	O00515	LAD1_HUMAN	ladinin 1	43						basement membrane	structural molecule activity				0						GGAGCCTCATCGTCCGTGGTG	0.642		NA											8	34					0	0	0	0
FGF19	9965	broad.mit.edu	37	11	69518109	69518109	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr11:69518109C>T	uc001opf.2	-	2	719	c.256G>A	c.(256-258)GCT>ACT	p.A86T		NM_005117	NP_005108	O95750	FGF19_HUMAN	fibroblast growth factor 19 precursor	86					fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|negative regulation of bile acid biosynthetic process|nervous system development|positive regulation of cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of glucose import|positive regulation of JNK cascade	extracellular region	fibroblast growth factor receptor binding|growth factor activity			skin(1)	1	all_cancers(3;5.53e-114)|all_epithelial(3;1.34e-121)|Breast(3;9.28e-34)|all_lung(4;1.99e-21)|Lung NSC(4;4.65e-21)|Hepatocellular(3;6.15e-15)|Melanoma(5;1.89e-05)|Ovarian(3;0.0348)		Epithelial(3;3.05e-56)|all cancers(3;2.69e-50)|Lung(3;1.13e-16)|LUSC - Lung squamous cell carcinoma(11;3.74e-15)|STAD - Stomach adenocarcinoma(18;0.0278)|LUAD - Lung adenocarcinoma(13;0.0537)			GTCCGCAGAGCGACTGCCTTG	0.677		NA											5	19					0	0	0	0
CLPB	81570	broad.mit.edu	37	11	72145270	72145270	+	Silent	SNP	G	G	T			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr11:72145270G>T	uc001osj.2	-	1	299	c.249C>A	c.(247-249)CTC>CTA	p.L83L	CLPB_uc010rqx.1_Missense_Mutation_p.R3S|CLPB_uc010rqy.1_Silent_p.L83L|CLPB_uc001osk.2_Silent_p.L83L|CLPB_uc009ytg.2_RNA|CLPB_uc010rqz.1_5'UTR	NM_030813	NP_110440	Q9H078	CLPB_HUMAN	caseinolytic peptidase B	83					cellular response to heat		ATP binding|nucleoside-triphosphatase activity|protein binding			pancreas(1)	1						TGGCAGCCGCGAGGCATTTGG	0.692		NA									OREG0021194	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	45					1.11e-09	2.73e-09	1	0
SLCO2B1	11309	broad.mit.edu	37	11	74904300	74904300	+	Silent	SNP	C	C	T			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr11:74904300C>T	uc001owb.2	+	9	1500	c.1113C>T	c.(1111-1113)CCC>CCT	p.P371P	SLCO2B1_uc010rrq.1_Silent_p.P116P|SLCO2B1_uc010rrr.1_Silent_p.P227P|SLCO2B1_uc010rrs.1_Silent_p.P255P|SLCO2B1_uc001owc.2_Silent_p.P144P|SLCO2B1_uc001owd.2_Silent_p.P349P	NM_007256	NP_009187	O94956	SO2B1_HUMAN	solute carrier organic anion transporter family,	371	Helical; Name=7; (Potential).				sodium-independent organic anion transport	integral to membrane	sodium-independent organic anion transmembrane transporter activity			ovary(1)|breast(1)	2					Ergoloid mesylate(DB01049)	TACGCCACCCCATCTTCCTGC	0.627		NA											19	80					0	0	0	0
GPRC5A	9052	broad.mit.edu	37	12	13061574	13061574	+	Silent	SNP	C	C	T			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr12:13061574C>T	uc001rba.2	+	2	1041	c.391C>T	c.(391-393)CTG>TTG	p.L131L	GPRC5A_uc001raz.2_Silent_p.L131L	NM_003979	NP_003970	Q8NFJ5	RAI3_HUMAN	G protein-coupled receptor, family C, group 5,	131	Helical; Name=4; (Potential).					cytoplasmic vesicle membrane|Golgi apparatus|integral to plasma membrane	G-protein coupled receptor activity				0		Prostate(47;0.141)		BRCA - Breast invasive adenocarcinoma(232;0.0708)	Tretinoin(DB00755)	GCCCCTTTCCCTGTTGGTGAT	0.522		NA											48	183					0	0	0	0
OR10AD1	121275	broad.mit.edu	37	12	48596393	48596393	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr12:48596393C>T	uc001rrl.1	-	1	683	c.683G>A	c.(682-684)AGC>AAC	p.S228N		NM_001004134	NP_001004134	Q8NGE0	O10AD_HUMAN	olfactory receptor, family 10, subfamily AD,	228	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GGAGGCTTTGCTGAGGATGGT	0.507		NA											7	41					0	0	0	0
HOXC6	3223	broad.mit.edu	37	12	54422634	54422634	+	Missense_Mutation	SNP	G	G	T			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr12:54422634G>T	uc001sev.2	+	1	441	c.329G>T	c.(328-330)AGG>ATG	p.R110M	HOXC6_uc001ses.2_Missense_Mutation_p.R28M|HOXC5_uc001set.2_Intron|HOXC4_uc001seu.2_Intron	NM_004503	NP_004494	P09630	HXC6_HUMAN	homeobox C6 isoform 1	110					regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(2)|upper_aerodigestive_tract(1)	3						GAGCAGGGCAGGACTGCGCCC	0.468		NA											10	110					2.74e-10	6.79e-10	1	0
ACIN1	22985	broad.mit.edu	37	14	23532678	23532678	+	Missense_Mutation	SNP	A	A	T			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr14:23532678A>T	uc001wit.3	-	13	3206	c.2878T>A	c.(2878-2880)TTG>ATG	p.L960M	ACIN1_uc001wio.3_RNA|ACIN1_uc001wip.3_Missense_Mutation_p.L202M|ACIN1_uc001wiq.3_Missense_Mutation_p.L202M|ACIN1_uc001wir.3_Missense_Mutation_p.L233M|ACIN1_uc001wis.3_Missense_Mutation_p.L641M|ACIN1_uc010akg.2_Missense_Mutation_p.L947M	NM_014977	NP_055792	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	960					apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			ovary(2)|large_intestine(1)|skin(1)	4	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		GGTGGGGGCAAGGCCACCTCT	0.517		NA											18	44					0	0	0	0
SLC7A8	23428	broad.mit.edu	37	14	23609754	23609754	+	Silent	SNP	G	G	A			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr14:23609754G>A	uc001wiz.2	-	5	1440	c.714C>T	c.(712-714)TTC>TTT	p.F238F	SLC7A8_uc001wix.2_Silent_p.F35F|SLC7A8_uc010tnk.1_Intron|SLC7A8_uc010tnl.1_Silent_p.F133F|SLC7A8_uc001wiy.2_RNA|SLC7A8_uc010akj.2_Silent_p.F238F	NM_012244	NP_036376	Q9UHI5	LAT2_HUMAN	solute carrier family 7 (cationic amino acid	238	Helical; (Potential).				blood coagulation|cellular amino acid metabolic process|leukocyte migration|metal ion homeostasis|response to toxin	basolateral plasma membrane|cytoplasm|integral to plasma membrane	neutral amino acid transmembrane transporter activity|organic cation transmembrane transporter activity|peptide antigen binding|protein binding|toxin transporter activity			ovary(1)	1	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.00809)	L-Alanine(DB00160)|L-Glutamine(DB00130)|L-Phenylalanine(DB00120)	AGCCCTGAAGGAAAGCCAGTG	0.502		NA											13	164					0	0	0	0
KCNH5	27133	broad.mit.edu	37	14	63468148	63468148	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr14:63468148C>T	uc001xfx.2	-	4	385	c.334G>A	c.(334-336)GCA>ACA	p.A112T	KCNH5_uc001xfy.2_Missense_Mutation_p.A112T|KCNH5_uc001xfz.1_Missense_Mutation_p.A54T|KCNH5_uc001xga.2_Missense_Mutation_p.A54T	NM_139318	NP_647479	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H,	112	PAC.|Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			ovary(4)|skin(4)|central_nervous_system(1)	9				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		CTTATTGGTGCAATTTGCATA	0.423		NA											4	20					0	0	0	0
EXD2	55218	broad.mit.edu	37	14	69701570	69701570	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr14:69701570C>G	uc001xkt.2	+	7	1155	c.496C>G	c.(496-498)CCA>GCA	p.P166A	EXD2_uc001xku.2_Missense_Mutation_p.P36A|EXD2_uc001xkv.2_Missense_Mutation_p.P291A|EXD2_uc001xkw.2_Missense_Mutation_p.P166A|EXD2_uc010aqt.2_Missense_Mutation_p.P291A|EXD2_uc010tte.1_Missense_Mutation_p.P291A|EXD2_uc001xky.2_Missense_Mutation_p.P166A	NM_018199	NP_060669	Q9NVH0	EXD2_HUMAN	exonuclease 3'-5' domain containing 2	166					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding				0						GGTCGACATCCCATTTCGAAG	0.443		NA											9	45					0	0	0	0
DMXL2	23312	broad.mit.edu	37	15	51741321	51741321	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr15:51741321G>A	uc002abf.2	-	43	9196	c.8971C>T	c.(8971-8973)CGA>TGA	p.R2991*	DMXL2_uc002abd.2_Nonsense_Mutation_p.R1083*|DMXL2_uc010ufy.1_Nonsense_Mutation_p.R2992*|DMXL2_uc010bfa.2_Nonsense_Mutation_p.R2355*|DMXL2_uc002abc.2_RNA	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	2991						cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		CCAATGTTTCGAAATATGGAC	0.438		NA											6	43					0	0	0	0
SLC28A1	9154	broad.mit.edu	37	15	85488064	85488064	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr15:85488064G>C	uc002blg.2	+	18	2042	c.1840G>C	c.(1840-1842)GAG>CAG	p.E614Q	SLC28A1_uc010bnb.2_Missense_Mutation_p.E614Q|SLC28A1_uc010upe.1_Missense_Mutation_p.E448Q|SLC28A1_uc010upf.1_Missense_Mutation_p.E614Q|SLC28A1_uc010upg.1_Intron	NM_004213	NP_004204	O00337	S28A1_HUMAN	solute carrier family 28, member 1 isoform 1	614					nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding			skin(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(143;0.0587)			CAGTAGCTTTGAGATTTACCA	0.592		NA											14	48					0	0	0	0
MYLK3	91807	broad.mit.edu	37	16	46766444	46766444	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr16:46766444G>A	uc002eei.3	-	4	1254	c.1138C>T	c.(1138-1140)CGC>TGC	p.R380C	MYLK3_uc010vge.1_Missense_Mutation_p.R39C|MYLK3_uc002eej.1_Missense_Mutation_p.R39C	NM_182493	NP_872299	Q32MK0	MYLK3_HUMAN	myosin light chain kinase 3	380					cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			stomach(2)|skin(2)|large_intestine(1)|ovary(1)|central_nervous_system(1)	7		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				TGGAGGCAGCGCCCGGTCCCA	0.687		NA											7	25					0	0	0	0
KIAA1609	57707	broad.mit.edu	37	16	84520478	84520478	+	Silent	SNP	G	G	T			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr16:84520478G>T	uc002fib.2	-	5	824	c.717C>A	c.(715-717)GGC>GGA	p.G239G	KIAA1609_uc010vod.1_Silent_p.G212G|KIAA1609_uc002fic.2_RNA	NM_020947	NP_065998	Q6P9B6	K1609_HUMAN	hypothetical protein LOC57707	239							protein binding			ovary(2)	2						CAAAACCCCTGCCCTGGTCCA	0.567		NA											9	32					0.000274275	0.000639975	1	0
KIAA0100	9703	broad.mit.edu	37	17	26968962	26968962	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr17:26968962C>G	uc002hbu.2	-	7	810	c.711G>C	c.(709-711)CAG>CAC	p.Q237H	KIAA0100_uc002hbv.2_Missense_Mutation_p.Q237H|KIAA0100_uc010crr.1_Missense_Mutation_p.Q94H	NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	237						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					GCAGTTGGCTCTGGAAGAGGC	0.547		NA											15	63					0	0	0	0
EVPL	2125	broad.mit.edu	37	17	74006565	74006565	+	Silent	SNP	A	A	G			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr17:74006565A>G	uc002jqi.2	-	22	2949	c.2721T>C	c.(2719-2721)CCT>CCC	p.P907P	EVPL_uc010wss.1_Silent_p.P929P|EVPL_uc010wst.1_Silent_p.P377P	NM_001988	NP_001979	Q92817	EVPL_HUMAN	envoplakin	907	Central fibrous rod domain.|Potential.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			pancreas(2)|central_nervous_system(1)|skin(1)	4						CTGCTTGGGCAGGGCTCTCGG	0.642		NA											10	34					0	0	0	0
B3GNT3	10331	broad.mit.edu	37	19	17918902	17918902	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr19:17918902C>T	uc002nhk.1	+	2	371	c.286C>T	c.(286-288)CAG>TAG	p.Q96*	B3GNT3_uc002nhl.1_Nonsense_Mutation_p.Q96*|B3GNT3_uc010ebd.1_Nonsense_Mutation_p.Q96*|B3GNT3_uc010ebe.1_Nonsense_Mutation_p.Q96*	NM_014256	NP_055071	Q9Y2A9	B3GN3_HUMAN	UDP-GlcNAc:betaGal	96	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to plasma membrane	galactosyltransferase activity			upper_aerodigestive_tract(1)	1						TCCCCTGCTGCAGGACGTGCC	0.637		NA											4	27					0	0	0	0
ZNF568	374900	broad.mit.edu	37	19	37440779	37440779	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr19:37440779C>T	uc002ofc.2	+	7	1239	c.724C>T	c.(724-726)CGA>TGA	p.R242*	ZNF568_uc010efg.2_Intron|ZNF568_uc010xtn.1_Intron|ZNF568_uc002ofd.2_Nonsense_Mutation_p.R166*|ZNF568_uc010efe.2_Nonsense_Mutation_p.R166*|ZNF568_uc010eff.1_Intron	NM_198539	NP_940941	Q3ZCX4	ZN568_HUMAN	zinc finger protein 568	242	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TAGACATGAGCGAATTCATGC	0.378		NA											7	46					0	0	0	0
TBC1D17	79735	broad.mit.edu	37	19	50385367	50385367	+	Silent	SNP	C	C	T			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr19:50385367C>T	uc002pqo.2	+	6	749	c.597C>T	c.(595-597)CAC>CAT	p.H199H	TBC1D17_uc010enn.1_RNA|TBC1D17_uc010ybg.1_Silent_p.H166H|TBC1D17_uc002pqp.2_5'UTR|TBC1D17_uc002pqq.1_RNA|TBC1D17_uc002pqr.2_5'UTR|TBC1D17_uc002pqs.2_5'Flank	NM_024682	NP_078958	Q9HA65	TBC17_HUMAN	TBC1 domain family, member 17	199						intracellular	Rab GTPase activator activity				0		all_lung(116;0.000338)|Lung NSC(112;0.000446)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0116)|OV - Ovarian serous cystadenocarcinoma(262;0.017)		ACTCCTTCCACCACCTGCAGC	0.647		NA											12	260					0	0	0	0
SHANK1	50944	broad.mit.edu	37	19	51200915	51200915	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr19:51200915C>T	uc002psx.1	-	13	1887	c.1868G>A	c.(1867-1869)CGC>CAC	p.R623H		NM_016148	NP_057232	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	623					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			large_intestine(2)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		CTTGTCACTGCGGCTTTCTGC	0.547		NA											11	82					0	0	0	0
ZNF17	7565	broad.mit.edu	37	19	57931031	57931031	+	Silent	SNP	G	G	A			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr19:57931031G>A	uc002qoo.1	+	3	402	c.171G>A	c.(169-171)GAG>GAA	p.E57E	ZNF547_uc002qpm.3_Intron|ZNF17_uc002qop.1_Silent_p.E59E	NM_006959	NP_008890	P17021	ZNF17_HUMAN	zinc finger protein 17	57	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0234)|GBM - Glioblastoma multiforme(193;0.000426)|Lung(386;0.176)		AGGATGAGGAGGCACCTTCCA	0.493		NA											16	65					0	0	0	0
CYP1B1	1545	broad.mit.edu	37	2	38302533	38302533	+	Splice_Site	SNP	C	C	T			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr2:38302533C>T	uc002rqo.2	-	3	403	c.0_splice	c.e3-1			NM_000104	NP_000095	Q16678	CP1B1_HUMAN	cytochrome P450, family 1, subfamily B,						visual perception|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			ovary(1)|central_nervous_system(1)	2		all_hematologic(82;0.21)			Estrone(DB00655)	GGTGCCCATGCTGGGGACAGA	0.667		NA											7	40					0	0	0	0
DUSP2	1844	broad.mit.edu	37	2	96809654	96809654	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr2:96809654C>T	uc002svk.3	-	4	939	c.853G>A	c.(853-855)GAC>AAC	p.D285N		NM_004418	NP_004409	Q05923	DUS2_HUMAN	dual specificity phosphatase 2	285	Tyrosine-protein phosphatase.				endoderm formation|inactivation of MAPK activity|regulation of apoptosis	nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/threonine phosphatase activity			breast(1)	1		Ovarian(717;0.0228)				TTAACGAAGTCAAAGGCCTCG	0.622		NA											7	21					0	0	0	0
DNAH7	56171	broad.mit.edu	37	2	196729451	196729451	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr2:196729451G>C	uc002utj.3	-	41	7029	c.6928C>G	c.(6928-6930)CCC>GCC	p.P2310A		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2310	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						AGGTTCATGGGTTTTTTGCTT	0.433		NA											7	104					0	0	0	0
WFDC8	90199	broad.mit.edu	37	20	44180733	44180733	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr20:44180733C>G	uc002xow.2	-	6	737	c.658G>C	c.(658-660)GAG>CAG	p.E220Q	WFDC8_uc002xox.2_Missense_Mutation_p.E220Q	NM_181510	NP_852611	Q8IUA0	WFDC8_HUMAN	WAP four-disulfide core domain 8 precursor	220	WAP 3.					extracellular region	serine-type endopeptidase inhibitor activity				0		Myeloproliferative disorder(115;0.0122)				GGGCACTCCTCATCCTGCAGG	0.423		NA											13	89					0	0	0	0
GRIK1	2897	broad.mit.edu	37	21	30934006	30934006	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr21:30934006G>T	uc002yno.1	-	15	2759	c.2295C>A	c.(2293-2295)TGC>TGA	p.C765*	GRIK1_uc002ynn.2_Nonsense_Mutation_p.C750*|GRIK1_uc011acs.1_Nonsense_Mutation_p.C765*|GRIK1_uc011act.1_Nonsense_Mutation_p.C626*	NM_000830	NP_000821	P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	765	Extracellular (Potential).				central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			large_intestine(1)|ovary(1)|skin(1)	3					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	GAGTGAGGTTGCAGTTTCTCT	0.507		NA											11	58					7.04e-09	1.72e-08	1	0
MX2	4600	broad.mit.edu	37	21	42754440	42754440	+	Silent	SNP	C	C	T	rs145539486	byFrequency	TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr21:42754440C>T	uc002yzf.1	+	5	785	c.681C>T	c.(679-681)CCC>CCT	p.P227P	MX2_uc011aer.1_RNA	NM_002463	NP_002454	P20592	MX2_HUMAN	myxovirus resistance protein 2	227	GTP (Potential).				response to virus|type I interferon-mediated signaling pathway	cytoplasm|nucleus	GTP binding|GTPase activity			ovary(2)	2		Prostate(19;1.57e-07)|all_epithelial(19;0.0222)				TTGACCTTCCCGGCATCACCA	0.602		NA											9	78					0	0	0	0
CABP7	164633	broad.mit.edu	37	22	30125152	30125152	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr22:30125152G>A	uc003agl.2	+	4	545	c.475G>A	c.(475-477)GAG>AAG	p.E159K		NM_182527	NP_872333	Q86V35	CABP7_HUMAN	calcium binding protein 7	159	Cytoplasmic (Potential).					Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|plasma membrane	calcium ion binding				0			OV - Ovarian serous cystadenocarcinoma(5;0.00442)|Epithelial(10;0.215)|all cancers(5;0.233)			GACGGAGGAGGAGAGCCACCT	0.617		NA											6	21					0	0	0	0
MICALL1	85377	broad.mit.edu	37	22	38328571	38328571	+	Missense_Mutation	SNP	C	C	G			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr22:38328571C>G	uc003aui.2	+	11	2112	c.2028C>G	c.(2026-2028)GAC>GAG	p.D676E		NM_033386	NP_203744	Q8N3F8	MILK1_HUMAN	molecule interacting with Rab13	676						cytoplasm|cytoskeleton	protein binding|zinc ion binding			breast(1)	1	Melanoma(58;0.045)					TCCAGGCTGACCAGTACATCC	0.632		NA											14	70					0	0	0	0
PARP3	10039	broad.mit.edu	37	3	51978492	51978492	+	Silent	SNP	C	C	A			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr3:51978492C>A	uc003dby.2	+	4	770	c.399C>A	c.(397-399)ACC>ACA	p.T133T	RRP9_uc003dbw.1_5'Flank|PARP3_uc003dbz.2_Silent_p.T140T	NM_005485	NP_005476	Q9Y6F1	PARP3_HUMAN	poly (ADP-ribose) polymerase family, member 3	133					DNA repair|protein ADP-ribosylation	centriole|nucleus	NAD+ ADP-ribosyltransferase activity|protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000541)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		GGGAAAAGACCAAGAACAACT	0.517		NA											29	107					7.01e-11	1.75e-10	1	0
TRIM42	287015	broad.mit.edu	37	3	140401851	140401851	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr3:140401851C>T	uc003eto.1	+	2	1080	c.889C>T	c.(889-891)CGC>TGC	p.R297C		NM_152616	NP_689829	Q8IWZ5	TRI42_HUMAN	tripartite motif-containing 42	297	B box-type 2.					intracellular	zinc ion binding			lung(2)|skin(2)|upper_aerodigestive_tract(1)|breast(1)|central_nervous_system(1)	7						CCCATCCAGCCGCATCATCGA	0.552		NA											7	39					0	0	0	0
BCHE	590	broad.mit.edu	37	3	165547361	165547361	+	Silent	SNP	G	G	A	rs74458984		TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr3:165547361G>A	uc003fem.3	-	2	1621	c.1461C>T	c.(1459-1461)GCC>GCT	p.A487A	BCHE_uc003fen.3_Intron	NM_000055	NP_000046	P06276	CHLE_HUMAN	butyrylcholinesterase precursor	487					choline metabolic process|cocaine metabolic process|synaptic transmission, cholinergic	endoplasmic reticulum lumen|extracellular space|membrane	acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|enzyme binding			ovary(3)|pancreas(1)	4					Ambenonium(DB01122)|Atropine(DB00572)|Bambuterol(DB01408)|Chlorpromazine(DB00477)|Choline(DB00122)|Cinnarizine(DB00568)|Demecarium bromide(DB00944)|Dibucaine(DB00527)|Donepezil(DB00843)|Echothiophate Iodide(DB01057)|Edrophonium(DB01010)|Ethopropazine(DB00392)|Etomidate(DB00292)|Galantamine(DB00674)|Hexafluronium bromide(DB00941)|Isoflurophate(DB00677)|Mefloquine(DB00358)|Mivacurium(DB01226)|Neostigmine(DB01400)|Pancuronium(DB01337)|Pralidoxime(DB00733)|Procainamide(DB01035)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Succinylcholine(DB00202)|Terbutaline(DB00871)|Trimethaphan(DB01116)	AAATTTCCTCGGCTTTTGTGT	0.403		NA											20	53					0	0	0	0
CCKAR	886	broad.mit.edu	37	4	26483643	26483643	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr4:26483643C>T	uc003gse.1	-	5	1057	c.904G>A	c.(904-906)GCA>ACA	p.A302T		NM_000730	NP_000721	P32238	CCKAR_HUMAN	cholecystokinin A receptor	302	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|elevation of cytosolic calcium ion concentration|response to nutrient	integral to plasma membrane	cholecystokinin receptor activity			lung(3)|pancreas(1)	4		Breast(46;0.0503)			Ceruletide(DB00403)	AGGTTGGCTGCGGAGCTGTTA	0.612		NA											25	123					0	0	0	0
ODZ3	55714	broad.mit.edu	37	4	183721257	183721257	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr4:183721257C>T	uc003ivd.1	+	27	7890	c.7853C>T	c.(7852-7854)GCG>GTG	p.A2618V		NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	2618	Extracellular (Potential).				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		GAGGAGAAGGCGCGCATCCTG	0.751		NA											4	11					0	0	0	0
HIST1H2AM	8336	broad.mit.edu	37	6	27860847	27860847	+	Silent	SNP	A	A	G			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr6:27860847A>G	uc003nkb.1	-	1	117	c.81T>C	c.(79-81)CCT>CCC	p.P27P	HIST1H3J_uc003nka.2_5'Flank|HIST1H2BO_uc003nkc.1_5'Flank	NM_003514	NP_003505	P0C0S8	H2A1_HUMAN	histone cluster 1, H2am	27					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding			ovary(2)	2						CTCGTCCTACAGGAAATTGGA	0.647		NA											12	54					0	0	0	0
IP6K3	117283	broad.mit.edu	37	6	33690810	33690810	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr6:33690810C>T	uc010jvf.2	-	7	1456	c.920G>A	c.(919-921)CGG>CAG	p.R307Q	IP6K3_uc003ofb.2_Missense_Mutation_p.R307Q	NM_001142883	NP_001136355	Q96PC2	IP6K3_HUMAN	inositol hexakisphosphate kinase 3	307					inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|protein phosphorylation	cytoplasm	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol hexakisphosphate 6-kinase activity|inositol trisphosphate 3-kinase activity				0						GAGGAGGGCCCGGAGCTGGTG	0.552		NA											4	38					0	0	0	0
AQP1	358	broad.mit.edu	37	7	30951738	30951738	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr7:30951738G>A	uc003tbv.1	+	1	271	c.214G>A	c.(214-216)GGC>AGC	p.G72S	AQP1_uc011kac.1_Missense_Mutation_p.G132S	NM_198098	NP_932766	P29972	AQP1_HUMAN	aquaporin 1	72					ammonium transport|cell volume homeostasis|cellular hyperosmotic response|cellular response to cAMP|cellular response to copper ion|cellular response to dexamethasone stimulus|cellular response to hydrogen peroxide|cellular response to hypoxia|cellular response to mechanical stimulus|cellular response to mercury ion|cellular response to nitric oxide|cellular response to retinoic acid|cellular response to salt stress|cellular response to UV|cerebrospinal fluid secretion|cGMP biosynthetic process|establishment or maintenance of actin cytoskeleton polarity|lateral ventricle development|maintenance of symbiont-containing vacuole via substance secreted by host|negative regulation of apoptosis|odontogenesis|pancreatic juice secretion|positive regulation of angiogenesis|positive regulation of fibroblast proliferation|positive regulation of saliva secretion|renal water transport|response to drug|transepithelial water transport	apical plasma membrane|basal plasma membrane|brush border membrane|cytoplasm|integral to plasma membrane|nuclear membrane|sarcolemma|symbiont-containing vacuole	ammonia transmembrane transporter activity|carbon dioxide transmembrane transporter activity|glycerol transmembrane transporter activity|intracellular cGMP activated cation channel activity|nitric oxide transmembrane transporter activity|potassium channel activity|potassium ion transmembrane transporter activity|protein binding|water channel activity				0		Melanoma(862;0.16)			Acetazolamide(DB00819)	CCACATCAGCGGCGCCCACCT	0.657		NA											6	50					0	0	0	0
TRIM50	135892	broad.mit.edu	37	7	72730600	72730600	+	Missense_Mutation	SNP	T	T	C			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr7:72730600T>C	uc010lbd.1	-	6	963	c.838A>G	c.(838-840)ACC>GCC	p.T280A	FKBP6_uc003twz.2_Intron|TRIM50_uc003txy.1_Missense_Mutation_p.T280A|TRIM50_uc003txz.1_Missense_Mutation_p.T279A	NM_178125	NP_835226	Q86XT4	TRI50_HUMAN	tripartite motif protein 50A	280	B30.2/SPRY.					cytoplasm|intracellular membrane-bounded organelle	ligase activity|zinc ion binding			skin(1)	1						TTCCACACGGTCAGCTTGATG	0.617		NA											8	42					0	0	0	0
SLC13A4	26266	broad.mit.edu	37	7	135390963	135390963	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr7:135390963C>T	uc003vta.2	-	4	1140	c.451G>A	c.(451-453)GTG>ATG	p.V151M	SLC13A4_uc003vtb.2_Missense_Mutation_p.V151M	NM_012450	NP_036582	Q9UKG4	S13A4_HUMAN	solute carrier family 13 (sodium/sulfate	151						integral to plasma membrane	sodium:sulfate symporter activity				0						ACGGCCTCCACGATGGGCATC	0.612		NA											10	59					0	0	0	0
KIAA0196	9897	broad.mit.edu	37	8	126067886	126067886	+	Missense_Mutation	SNP	T	T	C			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr8:126067886T>C	uc003yrt.2	-	17	2373	c.2044A>G	c.(2044-2046)ATT>GTT	p.I682V	KIAA0196_uc011lir.1_Missense_Mutation_p.I534V|KIAA0196_uc003yru.1_Missense_Mutation_p.I256V	NM_014846	NP_055661	Q12768	STRUM_HUMAN	strumpellin	682					cell death	WASH complex				ovary(2)	2	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			TCAGTAAAAATGGAAATAGCA	0.383		NA											29	113					0	0	0	0
ZNF618	114991	broad.mit.edu	37	9	116750680	116750680	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr9:116750680G>C	uc004bid.2	+	3	256	c.157G>C	c.(157-159)GAG>CAG	p.E53Q	ZNF618_uc004bib.1_Missense_Mutation_p.E53Q|ZNF618_uc004bic.2_Missense_Mutation_p.E53Q|ZNF618_uc011lxi.1_Missense_Mutation_p.E53Q|ZNF618_uc011lxj.1_Missense_Mutation_p.E53Q	NM_133374	NP_588615	Q5T7W0	ZN618_HUMAN	zinc finger protein 618	53					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GCTGAGTGCCGAGCAAGGAAC	0.612		NA											6	22					0	0	0	0
CEP110	11064	broad.mit.edu	37	9	123860779	123860779	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr9:123860779C>T	uc004bkx.1	+	5	768	c.737C>T	c.(736-738)TCA>TTA	p.S246L	CEP110_uc004bkw.2_Missense_Mutation_p.S246L	NM_007018	NP_008949	Q7Z7A1	CNTRL_HUMAN	centrosomal protein 110kDa	246	LRRCT.				cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding				0						CACCTCCGTTCATTGGAAAGT	0.373		NA											8	27					0	0	0	0
TEK	7010	broad.mit.edu	37	9	27220064	27220064	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CQ-6227-01A-11D-1912-08	TCGA-CQ-6227-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ca62509e-d477-41ca-9bc2-3f20c2dd4e49	5c2ca813-1c97-44ea-ab63-2e35604115d6	g.chr9:27220064delG	uc003zqi.3	+	21	3563	c.3121delG	c.(3121-3123)GGGfs	p.G1041fs	TEK_uc011lno.1_Frame_Shift_Del_p.G998fs|TEK_uc011lnp.1_Frame_Shift_Del_p.G893fs	NM_000459	NP_000450	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial precursor	1041	Protein kinase.|Cytoplasmic (Potential).				angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			ovary(3)|central_nervous_system(3)|breast(3)|lung(2)|kidney(1)	12		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		ACCCTACTGCGGGATGACTTG	0.527		NA											27	89	---	---	---	---	NA	NA	NA	NA