Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
CDC20	991	broad.mit.edu	37	1	43825057	43825057	+	Silent	SNP	C	C	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr1:43825057C>T	uc001cix.2	+	2	272	c.171C>T	c.(169-171)GGC>GGT	p.G57G	CDC20_uc001ciy.2_Silent_p.G57G	NM_001255	NP_001246	Q12834	CDC20_HUMAN	cell division cycle 20	57					activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of synapse maturation|positive regulation of synaptic plasticity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	cytosol|nucleoplasm|spindle	enzyme binding|protein C-terminus binding				0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GGACTCCGGGCCGAACTCCTG	0.662		NA											20	10					0	0	0	0
RAD54L	8438	broad.mit.edu	37	1	46739822	46739822	+	Silent	SNP	C	C	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr1:46739822C>T	uc009vye.2	+	16	1737	c.1623C>T	c.(1621-1623)GTC>GTT	p.V541V	RAD54L_uc001cpl.2_Silent_p.V541V|RAD54L_uc001cpm.1_Silent_p.V324V	NM_001142548	NP_001136020	Q92698	RAD54_HUMAN	RAD54-like protein	541	Helicase C-terminal.				meiosis	nucleus	ATP binding|DNA binding|helicase activity			ovary(2)|skin(1)	3	Acute lymphoblastic leukemia(166;0.155)	Breast(1374;0.0634)		KIRC - Kidney renal clear cell carcinoma(1967;0.000896)		ACTTATACGTCCGCCTGGATG	0.423		NA						Direct_reversal_of_damage|Homologous_recombination					12	15					0	0	0	0
CYP4Z1	199974	broad.mit.edu	37	1	47583599	47583599	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr1:47583599T>C	uc001cqu.1	+	12	1514	c.1511T>C	c.(1510-1512)GTT>GCT	p.V504A		NM_178134	NP_835235	Q86W10	CP4Z1_HUMAN	cytochrome P450 4Z1	504	Lumenal (Potential).					endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			skin(1)	1						GCAAAAAAAGTTTGCTAATTT	0.378		NA											13	12					0	0	0	0
C1orf173	127254	broad.mit.edu	37	1	75072415	75072415	+	Silent	SNP	T	T	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr1:75072415T>A	uc001dgg.2	-	10	1578	c.1359A>T	c.(1357-1359)TCA>TCT	p.S453S	uc001dgh.2_Intron|C1orf173_uc001dgi.3_Silent_p.S247S	NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	453	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						AAAATTTGGCTGAAACAGAGG	0.413		NA											93	48					0	0	0	0
CLCA4	22802	broad.mit.edu	37	1	87043754	87043754	+	Silent	SNP	C	C	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr1:87043754C>T	uc009wcs.2	+	12	2165	c.2121C>T	c.(2119-2121)AAC>AAT	p.N707N	CLCA4_uc009wct.2_Silent_p.N470N|CLCA4_uc009wcu.2_Silent_p.N527N	NM_012128	NP_036260	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	707						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			ovary(2)	2		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		GGGTAGTGAACGGTGAGTAAC	0.388		NA											3	7					0	0	0	0
DPYD	1806	broad.mit.edu	37	1	98164954	98164954	+	Silent	SNP	G	G	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr1:98164954G>A	uc001drv.2	-	6	770	c.633C>T	c.(631-633)TAC>TAT	p.Y211Y	DPYD_uc010oub.1_RNA	NM_000110	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase isoform 1	211					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			ovary(3)|skin(3)|breast(2)	8		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	TGATGTCAGAGTACCCCAATC	0.383		NA											72	40					0	0	0	0
S1PR1	1901	broad.mit.edu	37	1	101705292	101705292	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr1:101705292C>T	uc001dud.2	+	2	1266	c.752C>T	c.(751-753)TCG>TTG	p.S251L	S1PR1_uc009weg.2_Missense_Mutation_p.S251L	NM_001400	NP_001391	P21453	S1PR1_HUMAN	sphingosine-1-phosphate receptor 1	251	Cytoplasmic (By similarity).			KSL -> NV (in Ref. 1; AAA52336 and 2; AAC51905).	cell adhesion	integral to membrane	lysosphingolipid and lysophosphatidic acid receptor activity			ovary(2)|lung(1)	3						TCTGAGAAGTCGCTGGCGCTG	0.582		NA											51	49					0	0	0	0
HRNR	388697	broad.mit.edu	37	1	152187703	152187703	+	Silent	SNP	T	T	C			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr1:152187703T>C	uc001ezt.1	-	3	6478	c.6402A>G	c.(6400-6402)GGA>GGG	p.G2134G		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2134					keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGCCGTGTTGTCCGTAGCCAG	0.567		NA											22	631					0	0	0	0
KIRREL	55243	broad.mit.edu	37	1	158064599	158064599	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr1:158064599C>T	uc001frn.3	+	15	2367	c.1963C>T	c.(1963-1965)CGG>TGG	p.R655W	KIRREL_uc010pib.1_Missense_Mutation_p.R555W|KIRREL_uc009wsq.2_Missense_Mutation_p.R491W|KIRREL_uc001fro.3_Missense_Mutation_p.R469W|uc001frp.2_5'Flank	NM_018240	NP_060710	Q96J84	KIRR1_HUMAN	kin of IRRE like precursor	655	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1	all_hematologic(112;0.0378)					CACCTATAGCCGGGGCCCTGC	0.657		NA											13	29					0	0	0	0
ALDH9A1	223	broad.mit.edu	37	1	165667675	165667675	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr1:165667675C>T	uc001gdh.1	-	1	226	c.121G>A	c.(121-123)GGG>AGG	p.G41R	uc001gdi.2_5'Flank|ALDH9A1_uc010pky.1_5'UTR|ALDH9A1_uc010pkz.1_Missense_Mutation_p.G41R|ALDH9A1_uc010pla.1_5'UTR	NM_000696	NP_000687	P49189	AL9A1_HUMAN	aldehyde dehydrogenase 9A1	17					carnitine biosynthetic process|cellular aldehyde metabolic process|hormone metabolic process|neurotransmitter biosynthetic process	cytosol|plasma membrane	3-chloroallyl aldehyde dehydrogenase activity|4-trimethylammoniobutyraldehyde dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|aminobutyraldehyde dehydrogenase activity				0	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				NADH(DB00157)	ACGCGGGCCCCGCCGCGGTAA	0.706		NA											14	24					0	0	0	0
FMO3	2328	broad.mit.edu	37	1	171085379	171085379	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr1:171085379G>A	uc001ghi.2	+	8	1326	c.1215G>A	c.(1213-1215)ATG>ATA	p.M405I	FMO3_uc001ghh.2_Missense_Mutation_p.M405I|FMO3_uc010pmb.1_Missense_Mutation_p.M385I|FMO3_uc010pmc.1_Missense_Mutation_p.M342I	NM_001002294	NP_001002294	P31513	FMO3_HUMAN	flavin containing monooxygenase 3	405				PSMEDM -> GPFYGKTL (in Ref. 1; AAA86284).	xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TGGAAGACATGATGAATGATA	0.358		NA											31	53					0	0	0	0
PAPPA2	60676	broad.mit.edu	37	1	176760576	176760576	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr1:176760576C>A	uc001gkz.2	+	19	6142	c.4978C>A	c.(4978-4980)CTG>ATG	p.L1660M	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1660	Sushi 5.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						CCCCTCAGAGCTGAATTCTGT	0.438		NA											25	27					1.43e-11	1.65e-11	1	0
USH2A	7399	broad.mit.edu	37	1	215848787	215848787	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr1:215848787C>T	uc001hku.1	-	63	12853	c.12466G>A	c.(12466-12468)GAC>AAC	p.D4156N		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	4156	Extracellular (Potential).|Fibronectin type-III 27.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AGCTGAGAGTCTGGAGGGGCT	0.542		NA								HNSCC(13;0.011)			3	62					0	0	0	0
AKT3	10000	broad.mit.edu	37	1	243778440	243778440	+	Silent	SNP	A	A	C			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr1:243778440A>C	uc001iab.1	-	6	666	c.585T>G	c.(583-585)ACT>ACG	p.T195T	AKT3_uc001hzz.1_Silent_p.T195T	NM_005465	NP_005456	Q9Y243	AKT3_HUMAN	AKT3 kinase isoform 1	195	Protein kinase.				signal transduction	Golgi apparatus|nucleus|plasma membrane	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(1)|lung(1)|breast(1)|central_nervous_system(1)	4	all_cancers(71;0.000307)|all_epithelial(71;0.000374)|all_lung(81;0.0323)|Ovarian(71;0.0619)|all_neural(11;0.101)|Lung NSC(105;0.168)	all_cancers(173;0.0274)	all cancers(7;4.3e-08)|GBM - Glioblastoma multiforme(7;5.12e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00196)			CTCTGCTTTCAGTTAGAGTGT	0.294		NA											19	43					0	0	0	0
AHCTF1	25909	broad.mit.edu	37	1	247051786	247051786	+	Silent	SNP	A	A	G			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr1:247051786A>G	uc001ibu.1	-	17	2185	c.2178T>C	c.(2176-2178)GAT>GAC	p.D726D	AHCTF1_uc001ibv.1_Silent_p.D735D|AHCTF1_uc009xgs.1_5'UTR	NM_015446	NP_056261	Q8WYP5	ELYS_HUMAN	transcription factor ELYS	726	Necessary for cytoplasmic localization (By similarity).				cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			ovary(5)|skin(2)	7	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			AAACCAGTCCATCAATCATCA	0.408		NA											32	26					0	0	0	0
DCLRE1C	64421	broad.mit.edu	37	10	14961768	14961768	+	Silent	SNP	C	C	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr10:14961768C>A	uc001inn.2	-	13	1210	c.1125G>T	c.(1123-1125)CTG>CTT	p.L375L	DCLRE1C_uc010qbx.1_Silent_p.L375L|DCLRE1C_uc001ink.2_Silent_p.L28L|DCLRE1C_uc001inl.2_Silent_p.L255L|DCLRE1C_uc009xji.2_Silent_p.L260L|DCLRE1C_uc001inm.2_Silent_p.L255L|DCLRE1C_uc001ino.2_Silent_p.L260L|DCLRE1C_uc009xjh.2_RNA|DCLRE1C_uc001inp.2_Silent_p.L255L|DCLRE1C_uc001inq.2_Silent_p.L255L|DCLRE1C_uc001inr.2_Silent_p.L260L	NM_001033855	NP_001029027	Q96SD1	DCR1C_HUMAN	artemis protein isoform a	375					DNA recombination	nucleus	5'-3' exonuclease activity|single-stranded DNA specific endodeoxyribonuclease activity			ovary(1)	1						TAGCTCTCTTCAGTTTTCCCA	0.458		NA						Involved_in_tolerance_or_repair_of_DNA_crosslinks|NHEJ					38	81					3.62e-18	4.32e-18	1	0
GRID1	2894	broad.mit.edu	37	10	87966319	87966319	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr10:87966319C>T	uc001kdl.1	-	3	423	c.322G>A	c.(322-324)GCC>ACC	p.A108T	GRID1_uc009xsu.1_RNA	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	108	Extracellular (Potential).					cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)	ATGTGCATGGCATCCGTGAGG	0.607		NA								Multiple Myeloma(13;0.14)			14	30					0	0	0	0
C10orf12	26148	broad.mit.edu	37	10	98743204	98743204	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr10:98743204A>G	uc001kmv.2	+	1	2164	c.2057A>G	c.(2056-2058)AAC>AGC	p.N686S		NM_015652	NP_056467	Q8N655	CJ012_HUMAN	hypothetical protein LOC26148	686										skin(2)	2		Colorectal(252;0.172)		Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)		GAGGTAGACAACGAAAACACC	0.502		NA											19	20					0	0	0	0
TACC2	10579	broad.mit.edu	37	10	123954555	123954555	+	Silent	SNP	G	G	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr10:123954555G>A	uc001lfv.2	+	8	6195	c.5835G>A	c.(5833-5835)AGG>AGA	p.R1945R	TACC2_uc001lfw.2_Silent_p.R91R|TACC2_uc009xzx.2_Silent_p.R1900R|TACC2_uc010qtv.1_Silent_p.R1949R|TACC2_uc001lfx.2_5'UTR|TACC2_uc001lfy.2_5'UTR|TACC2_uc001lfz.2_Missense_Mutation_p.M23I|TACC2_uc001lga.2_Missense_Mutation_p.M23I|TACC2_uc009xzy.2_Missense_Mutation_p.M23I|TACC2_uc010qtw.1_Silent_p.R40R	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	1945						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				CTCTCATCAGGAGTTCCGATT	0.617		NA											38	96					0	0	0	0
OAT	4942	broad.mit.edu	37	10	126100543	126100543	+	Silent	SNP	T	T	C			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr10:126100543T>C	uc001lhp.2	-	2	305	c.198A>G	c.(196-198)AAA>AAG	p.K66K	OAT_uc001lhq.2_RNA|OAT_uc001lhr.2_Intron	NM_000274	NP_000265	P04181	OAT_HUMAN	ornithine aminotransferase precursor	66					cellular amino acid biosynthetic process|visual perception	mitochondrial matrix	ornithine-oxo-acid transaminase activity|protein binding|pyridoxal phosphate binding				0		all_lung(145;0.0271)|Lung NSC(174;0.0436)|Colorectal(57;0.102)|all_neural(114;0.116)			L-Ornithine(DB00129)|Pyridoxal Phosphate(DB00114)	GAAACGTACCTTTTCCTCTCT	0.363		NA											3	92					0	0	0	0
UBQLN3	50613	broad.mit.edu	37	11	5530480	5530480	+	Silent	SNP	T	T	G			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr11:5530480T>G	uc001may.1	-	2	395	c.309A>C	c.(307-309)CCA>CCC	p.P103P	HBG2_uc001mak.1_Intron	NM_017481	NP_059509	Q9H347	UBQL3_HUMAN	ubiquilin 3	103										ovary(3)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CAGAGGCAGCTGGGCACTCAT	0.597		NA											11	29					0	0	0	0
SBF2	81846	broad.mit.edu	37	11	9878164	9878164	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr11:9878164A>T	uc001mib.2	-	19	2342	c.2204T>A	c.(2203-2205)CTA>CAA	p.L735Q	SBF2_uc001mif.3_Missense_Mutation_p.L491Q|uc001mig.2_Intron	NM_030962	NP_112224	Q86WG5	MTMRD_HUMAN	SET binding factor 2	735					myelination	cytoplasm|membrane	phosphatase activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				all cancers(16;2.88e-11)|Epithelial(150;3.61e-10)|BRCA - Breast invasive adenocarcinoma(625;0.00887)		ATGTTGCACTAGCTCTTGCTG	0.483		NA											59	161					0	0	0	0
ABCC8	6833	broad.mit.edu	37	11	17496473	17496473	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr11:17496473C>T	uc001mnc.2	-	2	376	c.250G>A	c.(250-252)GTC>ATC	p.V84I	ABCC8_uc010rcy.1_Missense_Mutation_p.V84I	NM_000352	NP_000343	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C, member 8	84	Helical; Name=2; (By similarity).				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	CACACCAGGACGAAGAGCAGC	0.547		NA											11	20					0	0	0	0
ELF5	2001	broad.mit.edu	37	11	34502384	34502384	+	Silent	SNP	T	T	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr11:34502384T>A	uc001mvo.1	-	6	866	c.636A>T	c.(634-636)GCA>GCT	p.A212A	ELF5_uc001mvp.1_Silent_p.A202A|ELF5_uc009ykd.1_Silent_p.A107A	NM_198381	NP_938195	Q9UKW6	ELF5_HUMAN	E74-like factor 5 ESE-2a	212	ETS.				cell proliferation|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1		Acute lymphoblastic leukemia(5;0.0087)|all_hematologic(20;0.0384)				CCCACATCTTTGCCAGGGCTT	0.418		NA											52	64					0	0	0	0
LRRC4C	57689	broad.mit.edu	37	11	40137317	40137317	+	Silent	SNP	G	G	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr11:40137317G>T	uc001mxa.1	-	2	2490	c.526C>A	c.(526-528)CGA>AGA	p.R176R	LRRC4C_uc001mxc.1_Silent_p.R172R|LRRC4C_uc001mxd.1_Silent_p.R172R|LRRC4C_uc001mxb.1_Silent_p.R172R	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	176	LRR 5.				regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				AAGTCTAGTCGGCGCAAAGAA	0.423		NA											32	38					6.01e-18	7.13e-18	1	0
FOLH1	2346	broad.mit.edu	37	11	49207301	49207301	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr11:49207301G>A	uc001ngy.2	-	6	1007	c.746C>T	c.(745-747)CCT>CTT	p.P249L	FOLH1_uc001ngz.2_Missense_Mutation_p.P249L|FOLH1_uc009yly.2_Missense_Mutation_p.P234L|FOLH1_uc009ylz.2_Missense_Mutation_p.P234L|FOLH1_uc009yma.2_Intron	NM_004476	NP_004467	Q04609	FOLH1_HUMAN	folate hydrolase 1 isoform 1	249	Extracellular (Probable).				proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			large_intestine(1)|ovary(1)|skin(1)	3					Capromab(DB00089)|L-Glutamic Acid(DB00142)	ACCACCTCCAGGAAGATTCCA	0.512		NA											12	35					0	0	0	0
OR4A16	81327	broad.mit.edu	37	11	55111275	55111275	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr11:55111275A>G	uc010rie.1	+	1	599	c.599A>G	c.(598-600)AAT>AGT	p.N200S		NM_001005274	NP_001005274	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A,	200	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(2)|pancreas(1)	3						GTGGTTGCCAATGGTGGAATA	0.423		NA											58	60					0	0	0	0
CCDC88B	283234	broad.mit.edu	37	11	64116884	64116884	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr11:64116884C>T	uc001nzy.2	+	15	2742	c.2698C>T	c.(2698-2700)CTC>TTC	p.L900F	CCDC88B_uc009ypo.1_Missense_Mutation_p.L897F|CCDC88B_uc001nzz.1_Missense_Mutation_p.L549F|CCDC88B_uc001oaa.2_Missense_Mutation_p.L52F	NM_032251	NP_115627	A6NC98	CC88B_HUMAN	coiled-coil domain containing 88	900	Potential.				microtubule cytoskeleton organization	cytoplasm	microtubule binding			ovary(3)|skin(1)	4						GCAGGCGGCTCTCGAGCGCCA	0.507		NA											4	23					0	0	0	0
SPTBN2	6712	broad.mit.edu	37	11	66466927	66466927	+	Silent	SNP	G	G	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr11:66466927G>T	uc001ojd.2	-	17	3798	c.3726C>A	c.(3724-3726)GGC>GGA	p.G1242G		NM_006946	NP_008877	O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	1242	Spectrin 9.				actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			large_intestine(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						CGTGGATGTTGCCTTCAGATA	0.557		NA											23	50					3.08e-08	3.47e-08	1	0
ME3	10873	broad.mit.edu	37	11	86198421	86198421	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr11:86198421T>G	uc001pbz.2	-	6	1021	c.767A>C	c.(766-768)TAC>TCC	p.Y256S	ME3_uc001pca.2_Missense_Mutation_p.Y256S|ME3_uc009yvk.2_Missense_Mutation_p.Y256S|ME3_uc010rtr.1_RNA	NM_001014811	NP_001014811	Q16798	MAON_HUMAN	mitochondrial malic enzyme 3 precursor	256					aerobic respiration|malate metabolic process|oxygen metabolic process|pyruvate metabolic process	mitochondrial matrix	malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity|metal ion binding|NAD binding			ovary(1)	1		Acute lymphoblastic leukemia(157;4.34e-06)|all_hematologic(158;0.00252)			NADH(DB00157)	CAAGTCATCGTATGCCTTCCC	0.527		NA											11	39					0	0	0	0
FAT3	120114	broad.mit.edu	37	11	92087366	92087366	+	Silent	SNP	A	A	G			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr11:92087366A>G	uc001pdj.3	+	1	2105	c.2088A>G	c.(2086-2088)CTA>CTG	p.L696L		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	696	Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CAGAGAAACTACTCATTAAGG	0.388		NA								TCGA Ovarian(4;0.039)			19	44					0	0	0	0
ATM	472	broad.mit.edu	37	11	108115564	108115564	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr11:108115564A>G	uc001pkb.1	+	7	1097	c.712A>G	c.(712-714)ATC>GTC	p.I238V	ATM_uc009yxr.1_Missense_Mutation_p.I238V	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	238					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		AGCTCTTACTATCTTCCTCAA	0.393		NA	D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			28	65					0	0	0	0
ATM	472	broad.mit.edu	37	11	108143284	108143284	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr11:108143284A>G	uc001pkb.1	+	21	3488	c.3103A>G	c.(3103-3105)ATA>GTA	p.I1035V	ATM_uc009yxr.1_Missense_Mutation_p.I1035V	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	1035					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		GAGGAAATATATATTCTCTGT	0.308		NA	D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			10	25					0	0	0	0
C11orf53	341032	broad.mit.edu	37	11	111155057	111155057	+	Silent	SNP	G	G	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr11:111155057G>A	uc001plc.2	+	3	411	c.264G>A	c.(262-264)CCG>CCA	p.P88P		NM_198498	NP_940900	Q8IXP5	CK053_HUMAN	hypothetical protein LOC341032	88											0		all_cancers(61;2.05e-09)|Melanoma(852;4.04e-05)|all_epithelial(67;6.15e-05)|all_hematologic(158;0.000826)|Acute lymphoblastic leukemia(157;0.000966)|all_neural(223;0.0332)|Medulloblastoma(222;0.0425)|Breast(348;0.147)		Epithelial(105;1.7e-06)|BRCA - Breast invasive adenocarcinoma(274;3.16e-06)|all cancers(92;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0507)		CCCTACCGCCGCTCCTGCCAC	0.662		NA											7	19					0	0	0	0
BSX	390259	broad.mit.edu	37	11	122848579	122848579	+	Silent	SNP	G	G	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr11:122848579G>A	uc010rzs.1	-	3	480	c.480C>T	c.(478-480)AAC>AAT	p.N160N		NM_001098169	NP_001091639	Q3C1V8	BSH_HUMAN	brain specific homeobox	160	Homeobox.										0		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0361)		TCATCCGCCGGTTCTGGAACC	0.527		NA											17	26					0	0	0	0
ITPR2	3709	broad.mit.edu	37	12	26812177	26812177	+	Missense_Mutation	SNP	A	A	C			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr12:26812177A>C	uc001rhg.2	-	16	2172	c.1755T>G	c.(1753-1755)ATT>ATG	p.I585M		NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	585	Cytoplasmic (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					TATCATAGCCAATCTGGGACT	0.368		NA											11	139					0	0	0	0
ARNTL2	56938	broad.mit.edu	37	12	27533231	27533231	+	Silent	SNP	G	G	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr12:27533231G>A	uc001rht.1	+	5	396	c.378G>A	c.(376-378)CTG>CTA	p.L126L	ARNTL2_uc001rhw.2_Silent_p.L89L|ARNTL2_uc010sjp.1_Silent_p.L89L|ARNTL2_uc001rhu.1_Silent_p.L112L|ARNTL2_uc009zji.1_Silent_p.L92L|ARNTL2_uc001rhv.1_Silent_p.L78L	NM_020183	NP_064568	Q8WYA1	BMAL2_HUMAN	aryl hydrocarbon receptor nuclear	126	Helix-loop-helix motif.				circadian rhythm|entrainment of circadian clock|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(1)|skin(1)	2	Colorectal(261;0.0847)|Lung SC(9;0.184)					TGAATAACCTGATTGAAGAAC	0.418		NA											17	132					0	0	0	0
CNTN1	1272	broad.mit.edu	37	12	41302265	41302265	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr12:41302265G>T	uc001rmm.1	+	2	144	c.31G>T	c.(31-33)GTG>TTG	p.V11L	CNTN1_uc009zjy.1_Missense_Mutation_p.V11L|CNTN1_uc001rmn.1_Missense_Mutation_p.V11L|CNTN1_uc001rmo.2_Missense_Mutation_p.V11L	NM_001843	NP_001834	Q12860	CNTN1_HUMAN	contactin 1 isoform 1 precursor	11					axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				lung(4)|ovary(3)|large_intestine(1)|skin(1)	9	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				CAGTCATCTTGTGATAATATC	0.299		NA											26	21					1.56e-20	1.87e-20	1	0
PRPF40B	25766	broad.mit.edu	37	12	50027756	50027756	+	Silent	SNP	C	C	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr12:50027756C>T	uc001rur.1	+	9	691	c.627C>T	c.(625-627)ACC>ACT	p.T209T	PRPF40B_uc001rup.1_Silent_p.T231T|PRPF40B_uc001ruq.1_Silent_p.T203T|PRPF40B_uc001rus.1_Silent_p.T152T	NM_001031698	NP_001026868	Q6NWY9	PR40B_HUMAN	Huntingtin interacting protein C isoform 1	209					mRNA processing|RNA splicing	nuclear speck				skin(2)|ovary(1)|pancreas(1)|kidney(1)	5						CTGGCCCCACCCCAGTGCCCA	0.642		NA											51	20					0	0	0	0
RASSF9	9182	broad.mit.edu	37	12	86198764	86198764	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr12:86198764C>G	uc001taf.1	-	2	1363	c.1024G>C	c.(1024-1026)GAG>CAG	p.E342Q		NM_005447	NP_005438	O75901	RASF9_HUMAN	Ras association (RalGDS/AF-6) domain family	342					endosome transport|protein targeting|signal transduction	cytosol|endosome|trans-Golgi network transport vesicle membrane	protein binding|transporter activity			ovary(1)	1						TATTTAATCTCTTTCTGGATG	0.373		NA											104	68					0	0	0	0
APAF1	317	broad.mit.edu	37	12	99060113	99060113	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr12:99060113A>G	uc001tfz.2	+	9	1917	c.1340A>G	c.(1339-1341)GAG>GGG	p.E447G	APAF1_uc001tfy.2_Missense_Mutation_p.E436G|APAF1_uc001tga.2_Missense_Mutation_p.E436G|APAF1_uc001tgb.2_Missense_Mutation_p.E447G|APAF1_uc001tgc.2_Intron	NM_181861	NP_863651	O14727	APAF_HUMAN	apoptotic peptidase activating factor 1 isoform	447					activation of caspase activity by cytochrome c|defense response|induction of apoptosis by intracellular signals|nervous system development	cytosol|Golgi apparatus|nucleus	ATP binding|caspase activator activity|protein binding			ovary(2)|lung(1)	3					Adenosine triphosphate(DB00171)	TTTCTTACAGAGAAGAATTGC	0.254		NA											28	30					0	0	0	0
SLC5A8	160728	broad.mit.edu	37	12	101603574	101603574	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr12:101603574A>T	uc001thz.3	-	1	443	c.53T>A	c.(52-54)TTC>TAC	p.F18Y		NM_145913	NP_666018	Q8N695	SC5A8_HUMAN	solute carrier family 5 (iodide transporter),	18	Helical; (Potential).				apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity				0						CATGCCCGCGAACACCACGTA	0.692		NA											16	8					0	0	0	0
DDX55	57696	broad.mit.edu	37	12	124104214	124104214	+	Silent	SNP	G	G	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr12:124104214G>A	uc001ufi.2	+	13	1593	c.1569G>A	c.(1567-1569)AAG>AAA	p.K523K	DDX55_uc001ufh.2_3'UTR|DDX55_uc001ufk.2_Silent_p.K376K|DDX55_uc001ufl.2_Silent_p.K130K	NM_020936	NP_065987	Q8NHQ9	DDX55_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 55	523	Lys-rich.						ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000142)|Epithelial(86;0.000637)|all cancers(50;0.00772)		cttggtcaaagcagaaggcca	0.144		NA											7	15					0	0	0	0
CDK8	1024	broad.mit.edu	37	13	26967636	26967636	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr13:26967636G>T	uc001uqr.1	+	7	805	c.779G>T	c.(778-780)GGA>GTA	p.G260V	CDK8_uc001uqs.1_Missense_Mutation_p.G260V|CDK8_uc001uqt.1_Missense_Mutation_p.G87V	NM_001260	NP_001251	P49336	CDK8_HUMAN	cyclin-dependent kinase 8	260	Protein kinase.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mediator complex	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(2)|large_intestine(1)|ovary(1)|skin(1)	5	Colorectal(5;0.000442)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0384)|Epithelial(112;0.142)|OV - Ovarian serous cystadenocarcinoma(117;0.188)		AATGTAATGGGATTTCCTGCA	0.353		NA											69	52					5.94e-25	7.16e-25	1	0
RB1	5925	broad.mit.edu	37	13	48951101	48951101	+	Silent	SNP	T	T	C			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr13:48951101T>C	uc001vcb.2	+	13	1429	c.1263T>C	c.(1261-1263)GAT>GAC	p.D421D	RB1_uc010act.1_Silent_p.D122D	NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	421	Domain A.|Pocket; binds T and E1A.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(7)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GAGTGAAGGATATAGGATACA	0.358		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			28	16					0	0	0	0
MLNR	2862	broad.mit.edu	37	13	49795353	49795353	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr13:49795353C>T	uc010tgj.1	+	1	880	c.880C>T	c.(880-882)CGG>TGG	p.R294W		NM_001507	NP_001498	O43193	MTLR_HUMAN	motilin receptor	294	Cytoplasmic (Potential).				digestion	integral to plasma membrane	growth hormone-releasing hormone receptor activity				0		all_lung(13;8.31e-06)|Lung NSC(96;0.000251)|Breast(56;0.0008)|Prostate(109;0.00446)|Hepatocellular(98;0.0556)|Glioma(44;0.236)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;6.1e-09)		GAGAGGCCACCGGCAGACCGT	0.736		NA											3	2					0	0	0	0
RBM26	64062	broad.mit.edu	37	13	79945213	79945213	+	Silent	SNP	G	G	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr13:79945213G>A	uc001vkz.2	-	5	515	c.501C>T	c.(499-501)GAC>GAT	p.D167D	RBM26_uc001vky.2_Silent_p.D167D|RBM26_uc001vla.2_Silent_p.D167D|RBM26_uc001vkx.2_5'Flank|RBM26_uc001vlb.1_RNA	NM_022118	NP_071401	Q5T8P6	RBM26_HUMAN	RNA binding motif protein 26	167	Arg-rich.				mRNA processing		nucleotide binding|protein binding|RNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(28;0.0279)		GBM - Glioblastoma multiforme(99;0.0188)		TATTGTACCGGTCTCTGTATG	0.453		NA											49	32					0	0	0	0
ERCC5	2073	broad.mit.edu	37	13	103513864	103513864	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr13:103513864A>T	uc001vpw.2	+	7	1123	c.680A>T	c.(679-681)GAT>GTT	p.D227V	ERCC5_uc001vpu.1_Missense_Mutation_p.D681V|ERCC5_uc010tjb.1_Missense_Mutation_p.D227V|ERCC5_uc010tjc.1_RNA|ERCC5_uc010tjd.1_Missense_Mutation_p.D59V	NM_000123	NP_000114	P28715	ERCC5_HUMAN	XPG-complementing protein	227					negative regulation of apoptosis|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|response to UV-C|transcription-coupled nucleotide-excision repair|UV protection	nucleoplasm	bubble DNA binding|double-stranded DNA binding|endodeoxyribonuclease activity|metal ion binding|protein homodimerization activity|protein N-terminus binding|single-stranded DNA binding			ovary(4)|lung(1)|central_nervous_system(1)|skin(1)	7	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					TAGGAGTCTGATGACTTTTCA	0.338		NA	Mis|N|F			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				36	21					0	0	0	0
RNF31	55072	broad.mit.edu	37	14	24624491	24624491	+	Silent	SNP	C	C	G			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr14:24624491C>G	uc001wmn.1	+	12	2505	c.2256C>G	c.(2254-2256)CTC>CTG	p.L752L	RNF31_uc001wml.1_Silent_p.L601L|RNF31_uc001wmm.1_RNA|RNF31_uc010alg.1_Silent_p.L511L|RNF31_uc001wmo.1_Silent_p.L219L|RNF31_uc001wmp.2_RNA|RNF31_uc010alh.1_5'Flank	NM_017999	NP_060469	Q96EP0	RNF31_HUMAN	ring finger protein 31	752					CD40 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein linear polyubiquitination|T cell receptor signaling pathway	CD40 receptor complex|internal side of plasma membrane|LUBAC complex	ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(265;0.00861)		GCCCCGACCTCACCGATGACA	0.577		NA											40	33					0	0	0	0
HECTD1	25831	broad.mit.edu	37	14	31581699	31581699	+	Silent	SNP	T	T	C			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr14:31581699T>C	uc001wrc.1	-	35	6690	c.6201A>G	c.(6199-6201)TTA>TTG	p.L2067L	HECTD1_uc001wra.1_Silent_p.L193L|HECTD1_uc001wrb.1_Silent_p.L193L	NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	HECT domain containing 1	2067	K-box.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			ovary(3)|large_intestine(1)|lung(1)	5	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		ATTTGCTGGTTAATTGTTCAC	0.373		NA											16	33					0	0	0	0
C14orf104	55172	broad.mit.edu	37	14	50101425	50101425	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr14:50101425G>T	uc001wws.3	-	1	524	c.443C>A	c.(442-444)CCA>CAA	p.P148Q	SDCCAG1_uc010anj.1_Intron|C14orf104_uc001wwt.3_Missense_Mutation_p.P148Q	NM_018139	NP_060609	Q9NVR5	KTU_HUMAN	kintoun isoform 1	148					axonemal dynein complex assembly|ciliary cell motility|flagellar cell motility	cytoplasm					0	all_epithelial(31;0.0021)|Breast(41;0.0124)					AAGCGCGTCTGGATGGAAGAC	0.706		NA							Kartagener_syndrome				8	20					2.53e-12	2.94e-12	1	0
TBPL2	387332	broad.mit.edu	37	14	55903569	55903569	+	Silent	SNP	A	A	G			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr14:55903569A>G	uc001xby.2	-	2	318	c.318T>C	c.(316-318)GTT>GTC	p.V106V		NM_199047	NP_950248	Q6SJ96	TBPL2_HUMAN	TATA box binding protein like 2	106					multicellular organismal development|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding				0						TTTCCTGGGTAACTTCATCTG	0.423		NA											30	33					0	0	0	0
SYNE2	23224	broad.mit.edu	37	14	64679605	64679605	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr14:64679605A>G	uc001xgm.2	+	105	19168	c.18938A>G	c.(18937-18939)AAG>AGG	p.K6313R	SYNE2_uc001xgl.2_Missense_Mutation_p.K6313R|SYNE2_uc010apy.2_Missense_Mutation_p.K2698R|SYNE2_uc001xgn.2_Missense_Mutation_p.K1275R|SYNE2_uc001xgo.2_RNA|SYNE2_uc010aqa.2_Missense_Mutation_p.K283R|SYNE2_uc001xgq.2_Missense_Mutation_p.K678R|SYNE2_uc001xgr.2_Missense_Mutation_p.K96R|SYNE2_uc010tsi.1_5'Flank|SYNE2_uc001xgs.2_5'Flank	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	6313	Spectrin 8.|Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		CTGATTCAGAAGAGCGAGCCC	0.522		NA											48	39					0	0	0	0
ACOT2	10965	broad.mit.edu	37	14	74036297	74036297	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr14:74036297C>T	uc001xon.3	+	1	526	c.353C>T	c.(352-354)ACT>ATT	p.T118I	ACOT1_uc010tuc.1_Intron|ACOT2_uc001xom.2_Intron	NM_006821	NP_006812	P49753	ACOT2_HUMAN	acyl-CoA thioesterase 2	118					acyl-CoA metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process	mitochondrion	carboxylesterase activity|palmitoyl-CoA hydrolase activity|protein binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.0033)|OV - Ovarian serous cystadenocarcinoma(108;0.0639)		CGCGCCGACACTCTTGGCGAG	0.741		NA											17	16					0	0	0	0
OTUB2	78990	broad.mit.edu	37	14	94510931	94510931	+	Splice_Site	SNP	G	G	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr14:94510931G>A	uc001yci.2	+	5	464	c.304_splice	c.e5-1	p.F102_splice		NM_023112	NP_075601	Q96DC9	OTUB2_HUMAN	OTU domain, ubiquitin aldehyde binding 2						cellular amino acid metabolic process|protein K48-linked deubiquitination|protein K63-linked deubiquitination		omega peptidase activity|protein binding|ubiquitin-specific protease activity				0		all_cancers(154;0.12)		Epithelial(152;0.124)|all cancers(159;0.21)|COAD - Colon adenocarcinoma(157;0.215)		GGCGGGCGCAGTTTTACAGTG	0.622		NA											12	26					0	0	0	0
RYR3	6263	broad.mit.edu	37	15	34016286	34016286	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr15:34016286A>T	uc001zhi.2	+	45	6891	c.6821A>T	c.(6820-6822)GAG>GTG	p.E2274V	RYR3_uc010bar.2_Missense_Mutation_p.E2274V	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	2274	4 X approximate repeats.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GACGATGAAGAGGAAGAAGAA	0.502		NA											16	10					0	0	0	0
ONECUT1	3175	broad.mit.edu	37	15	53081808	53081808	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr15:53081808C>T	uc002aci.1	-	1	402	c.274G>A	c.(274-276)GAG>AAG	p.E92K		NM_004498	NP_004489	Q9UBC0	HNF6_HUMAN	one cut homeobox 1	92					endocrine pancreas development	nucleus	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding				0				all cancers(107;0.0708)		GGGGGAGTCTCGCAGGCCATG	0.657		NA											27	13					0	0	0	0
PRTG	283659	broad.mit.edu	37	15	55965703	55965703	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr15:55965703G>A	uc002adg.2	-	10	1766	c.1718C>T	c.(1717-1719)ACG>ATG	p.T573M	PRTG_uc002adh.2_Missense_Mutation_p.T75M	NM_173814	NP_776175	Q2VWP7	PRTG_HUMAN	protogenin precursor	573	Fibronectin type-III 2.				multicellular organismal development	integral to membrane				large_intestine(1)|ovary(1)|skin(1)	3				all cancers(107;0.00891)|GBM - Glioblastoma multiforme(80;0.135)		GTACTCATGCGTGGTCCCCGG	0.537		NA											39	20					0	0	0	0
IL16	3603	broad.mit.edu	37	15	81585276	81585276	+	Silent	SNP	A	A	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr15:81585276A>T	uc002bgh.3	+	12	2176	c.1800A>T	c.(1798-1800)CCA>CCT	p.P600P	IL16_uc002bgc.2_RNA|IL16_uc010blq.1_Intron|IL16_uc002bge.3_RNA|IL16_uc010unp.1_Silent_p.P642P|IL16_uc002bgg.2_Silent_p.P600P|IL16_uc002bgi.1_5'UTR|IL16_uc002bgj.2_Silent_p.P94P|IL16_uc002bgk.2_5'Flank	NM_172217	NP_757366	Q14005	IL16_HUMAN	interleukin 16 isoform 2	600					immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			ovary(2)|lung(1)|skin(1)	4						CCAAGCCTCCACCCAGAAAAT	0.547		NA											9	11					0	0	0	0
RPUSD1	113000	broad.mit.edu	37	16	836037	836037	+	Silent	SNP	T	T	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr16:836037T>A	uc002cka.2	-	5	1086	c.852A>T	c.(850-852)CCA>CCT	p.P284P	RPUSD1_uc002ckb.2_Silent_p.P284P|RPUSD1_uc002ckc.2_Silent_p.P155P|RPUSD1_uc002ckd.2_3'UTR|CHTF18_uc010uus.1_5'Flank|CHTF18_uc010bre.1_5'Flank|CHTF18_uc002cke.3_5'Flank|CHTF18_uc002ckf.3_5'Flank|CHTF18_uc010brf.2_5'Flank|CHTF18_uc002ckg.3_5'Flank	NM_058192	NP_478072	Q9UJJ7	RUSD1_HUMAN	RNA pseudouridylate synthase domain containing	284	Pro-rich.				pseudouridine synthesis		pseudouridine synthase activity|RNA binding				0		Hepatocellular(780;0.00335)				TGGTTGGGGGTGGAGGAGGCC	0.731		NA											3	6					0	0	0	0
SLC12A3	6559	broad.mit.edu	37	16	56914084	56914084	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr16:56914084G>A	uc010ccm.2	+	12	1515	c.1486G>A	c.(1486-1488)GGC>AGC	p.G496S	SLC12A3_uc002ekd.3_Missense_Mutation_p.G496S|SLC12A3_uc010ccn.2_Missense_Mutation_p.G495S	NM_001126108	NP_001119580	P55017	S12A3_HUMAN	solute carrier family 12, member 3 isoform 3	496	Cytoplasmic (Potential).		G -> C (in GS).		sodium ion transmembrane transport	apical plasma membrane|integral to plasma membrane|membrane fraction	sodium:chloride symporter activity			ovary(2)|breast(1)	3					Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Metolazone(DB00524)|Polythiazide(DB01324)|Quinethazone(DB01325)	CGGCTTCTTCGGCAAAGGCTA	0.612		NA											5	8					0	0	0	0
HP	3240	broad.mit.edu	37	16	72094648	72094648	+	Silent	SNP	C	C	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr16:72094648C>T	uc002fbr.3	+	7	1124	c.1080C>T	c.(1078-1080)GCC>GCT	p.A360A	TXNL4B_uc010cgl.2_Intron|HP_uc010cgm.2_Silent_p.A301A|HP_uc002fbt.3_Silent_p.A301A|HP_uc002fbu.1_Silent_p.A98A|HP_uc002fbv.3_Silent_p.A271A|HP_uc002fbw.3_Silent_p.A182A|HP_uc002fbx.3_Silent_p.A182A|HPR_uc002fby.2_5'Flank	NM_005143	NP_005134	P00738	HPT_HUMAN	haptoglobin isoform 1 preproprotein	360	Peptidase S1.				cellular iron ion homeostasis|defense response|negative regulation of hydrogen peroxide catabolic process|negative regulation of oxidoreductase activity|positive regulation of cell death|proteolysis|response to hydrogen peroxide	extracellular region|haptoglobin-hemoglobin complex	hemoglobin binding|serine-type endopeptidase activity				0		Renal(780;9.67e-05)|Ovarian(137;0.00327)|Hepatocellular(780;0.114)		BRCA - Breast invasive adenocarcinoma(221;0.00015)|Kidney(780;0.000529)		GTGCCTTTGCCGTTCACGACC	0.522		NA											20	69					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7577144	7577144	+	Missense_Mutation	SNP	A	A	C			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr17:7577144A>C	uc002gim.2	-	8	988	c.794T>G	c.(793-795)CTG>CGG	p.L265R	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.L265R|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.L133R|TP53_uc010cng.1_Missense_Mutation_p.L133R|TP53_uc002gii.1_Missense_Mutation_p.L133R|TP53_uc010cnh.1_Missense_Mutation_p.L265R|TP53_uc010cni.1_Missense_Mutation_p.L265R|TP53_uc002gij.2_Missense_Mutation_p.L265R	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	265	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		L -> M (in sporadic cancers; somatic mutation).|L -> Q (in sporadic cancers; somatic mutation).|L -> P (in LFS; germline mutation and in sporadic cancers; somatic mutation).|L -> R (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.L265P(14)|p.0?(7)|p.L265M(4)|p.L265R(3)|p.L265fs*80(3)|p.?(3)|p.L265L(3)|p.G262_F270delGNLLGRNSF(2)|p.L265del(2)|p.G262_S269delGNLLGRNS(2)|p.L265Q(1)|p.L265_K305del41(1)|p.E258fs*71(1)|p.L265_R267delLGR(1)|p.L265fs*81(1)|p.G262fs*2(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTTCCGTCCCAGTAGATTACC	0.522		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			15	8					0	0	0	0
PIK3R5	23533	broad.mit.edu	37	17	8812417	8812417	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr17:8812417C>A	uc002glt.2	-	3	245	c.178G>T	c.(178-180)GAG>TAG	p.E60*	PIK3R5_uc010vuz.1_Nonsense_Mutation_p.E60*|PIK3R5_uc002glu.3_5'UTR|PIK3R5_uc010coa.1_Nonsense_Mutation_p.E60*|PIK3R5_uc010cob.1_5'UTR	NM_014308	NP_055123	Q8WYR1	PI3R5_HUMAN	phosphoinositide-3-kinase, regulatory subunit 5	60	Heterodimerization (By similarity).				platelet activation	cytosol|membrane|nucleus				breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5						AGGATCTGCTCAAGGAGGATA	0.592		NA											4	5					5.94e-07	6.57e-07	1	0
MYH8	4626	broad.mit.edu	37	17	10304048	10304048	+	Silent	SNP	G	G	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr17:10304048G>T	uc002gmm.2	-	27	3489	c.3394C>A	c.(3394-3396)CGA>AGA	p.R1132R	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	1132	Potential.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle	p.R1132R(1)		skin(6)|ovary(3)|breast(2)	11						GCTTTGGCTCGGGACGCCCTC	0.557		NA							Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				6	51					0.00198382	0.00209976	1	0
MYH4	4622	broad.mit.edu	37	17	10360801	10360801	+	Silent	SNP	C	C	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr17:10360801C>A	uc002gmn.2	-	16	1944	c.1833G>T	c.(1831-1833)CTG>CTT	p.L611L	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	611	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						ACTTCTGGTACAGCCCCACCA	0.507		NA											25	33					1.18e-14	1.39e-14	1	0
TEKT3	64518	broad.mit.edu	37	17	15231309	15231309	+	Silent	SNP	C	C	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr17:15231309C>A	uc002gon.2	-	4	850	c.663G>T	c.(661-663)ACG>ACT	p.T221T		NM_031898	NP_114104	Q9BXF9	TEKT3_HUMAN	tektin 3	221					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(2)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0877)		CCACATTTACCGTCAGCAGTT	0.388		NA											127	72					3.47e-60	4.21e-60	1	0
TRIM16	10626	broad.mit.edu	37	17	15532098	15532098	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr17:15532098T>C	uc002gox.2	-	9	2083	c.1526A>G	c.(1525-1527)TAT>TGT	p.Y509C	TRIM16_uc002gor.1_Intron|TRIM16_uc002gow.2_Missense_Mutation_p.Y293C|TRIM16_uc002goy.2_Missense_Mutation_p.Y379C	NM_006470	NP_006461	O95361	TRI16_HUMAN	tripartite motif-containing 16	509	B30.2/SPRY.				histone H3 acetylation|histone H4 acetylation|positive regulation of interleukin-1 beta secretion|positive regulation of keratinocyte differentiation|positive regulation of retinoic acid receptor signaling pathway|positive regulation of transcription, DNA-dependent|response to growth hormone stimulus|response to organophosphorus|response to retinoic acid	cytoplasm|plasma membrane|PML body	DNA binding|interleukin-1 binding|NACHT domain binding|zinc ion binding			ovary(2)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (92;0.0839)|Epithelial(1;8.4e-29)|all cancers(1;3.06e-28)|Colorectal(1;1.57e-19)|OV - Ovarian serous cystadenocarcinoma(1;6.1e-17)|COAD - Colon adenocarcinoma(1;3.38e-12)|READ - Rectum adenocarcinoma(2;1.46e-05)|BRCA - Breast invasive adenocarcinoma(8;0.0559)		CTCTACGCCATAGAAGGAAAG	0.517		NA											27	158					0	0	0	0
RFFL	117584	broad.mit.edu	37	17	33338994	33338994	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr17:33338994C>T	uc002hin.1	-	7	1258	c.1085G>A	c.(1084-1086)CGG>CAG	p.R362Q	RFFL_uc002hiq.2_Missense_Mutation_p.R271Q|RFFL_uc002him.1_Missense_Mutation_p.R354Q|RFFL_uc010cti.1_Missense_Mutation_p.R368Q|RFFL_uc002hip.1_Missense_Mutation_p.R326Q|RFFL_uc002hio.1_Missense_Mutation_p.R362Q	NM_001017368	NP_001017368	Q8WZ73	RFFL_HUMAN	rififylin	362					apoptosis	membrane	ligase activity|zinc ion binding				0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)		CTCTCAGGACCGGAAGACATG	0.547		NA											8	24					0	0	0	0
KCNH4	23415	broad.mit.edu	37	17	40322268	40322268	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr17:40322268G>A	uc002hzb.2	-	8	1580	c.1247C>T	c.(1246-1248)TCG>TTG	p.S416L		NM_012285	NP_036417	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H,	416	Extracellular (Potential).				regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			large_intestine(1)	1		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		GCCGCCCACCGAGCCATTGAC	0.632		NA											9	8					0	0	0	0
NGFR	4804	broad.mit.edu	37	17	47590198	47590198	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr17:47590198G>A	uc002ioz.3	+	6	1236	c.1111G>A	c.(1111-1113)GAG>AAG	p.E371K		NM_002507	NP_002498	P08138	TNR16_HUMAN	nerve growth factor receptor precursor	371	Cytoplasmic (Potential).|Death.				anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|membrane protein intracellular domain proteolysis|negative regulation of axonogenesis|negative regulation of cell cycle|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis	cell surface|cytosol|endosome|extracellular region|integral to plasma membrane|nucleoplasm				ovary(1)|lung(1)	2	all_cancers(4;1.45e-13)|Breast(4;6.34e-28)|all_epithelial(4;4.95e-17)					CTACCAGCCCGAGCACATAGA	0.697		NA											31	64					0	0	0	0
C17orf71	55181	broad.mit.edu	37	17	57292263	57292263	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr17:57292263C>G	uc002ixi.2	+	4	2918	c.2876C>G	c.(2875-2877)GCA>GGA	p.A959G		NM_018149	NP_060619	Q8ND04	SMG8_HUMAN	SMG8 protein	959					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of protein kinase activity		protein binding				0	all_neural(34;0.0837)|Medulloblastoma(34;0.0922)					TTTCCTTATGCATATGTGACT	0.473		NA											32	48					0	0	0	0
AXIN2	8313	broad.mit.edu	37	17	63532996	63532996	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr17:63532996T>A	uc002jfi.2	-	7	2187	c.1898A>T	c.(1897-1899)AAG>ATG	p.K633M	AXIN2_uc002jfh.2_Intron	NM_004655	NP_004646	Q9Y2T1	AXIN2_HUMAN	axin 2	633				Missing (in Ref. 2; AAF22799).	cellular protein localization|cellular response to organic cyclic compound|dorsal/ventral axis specification|intramembranous ossification|maintenance of DNA repeat elements|mRNA stabilization|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of cell proliferation|negative regulation of osteoblast differentiation|odontogenesis|positive regulation of cell death|positive regulation of epithelial to mesenchymal transition|positive regulation of protein phosphorylation|regulation of centromeric sister chromatid cohesion|regulation of mismatch repair|Wnt receptor signaling pathway involved in somitogenesis	Axin-APC-beta-catenin-GSK3B complex|cell cortex|centrosome|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|nucleus|plasma membrane|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			central_nervous_system(1)|skin(1)	2						CCTATGGGGCTTGGGCTTGCT	0.652		NA							Oligodontia_Ectodermal_Dysplasia_and_Colorectal_Polyp_syndrome				37	107					0	0	0	0
ITGB4	3691	broad.mit.edu	37	17	73751849	73751849	+	Silent	SNP	A	A	C			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr17:73751849A>C	uc002jpg.2	+	35	4813	c.4626A>C	c.(4624-4626)ACA>ACC	p.T1542T	ITGB4_uc002jph.2_Silent_p.T1472T|ITGB4_uc002jpi.3_Silent_p.T1472T|ITGB4_uc002jpj.2_Silent_p.T1525T|GALK1_uc010wsi.1_Intron	NM_000213	NP_000204	P16144	ITB4_HUMAN	integrin beta 4 isoform 1 precursor	1542	Cytoplasmic (Potential).|Fibronectin type-III 3.				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			lung(4)	4	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			TGGGGCCCACATCTCTCAGAG	0.677		NA											10	44					0	0	0	0
LGALS3BP	3959	broad.mit.edu	37	17	76967771	76967771	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr17:76967771C>T	uc002jwh.2	-	6	1824	c.1645G>A	c.(1645-1647)GAC>AAC	p.D549N	LGALS3BP_uc002jwi.2_Missense_Mutation_p.D355N|LGALS3BP_uc010dhr.2_Missense_Mutation_p.D355N	NM_005567	NP_005558	Q08380	LG3BP_HUMAN	galectin 3 binding protein	549					cell adhesion|cellular defense response	extracellular space|membrane|proteinaceous extracellular matrix	protein binding|scavenger receptor activity			central_nervous_system(3)|ovary(1)	4			BRCA - Breast invasive adenocarcinoma(99;0.0677)|OV - Ovarian serous cystadenocarcinoma(97;0.139)			CTGTTGGTGTCCAGGGCACTG	0.607		NA									OREG0024787	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	56					0	0	0	0
DTNA	1837	broad.mit.edu	37	18	32428278	32428278	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr18:32428278C>A	uc010dmn.1	+	13	1285	c.1284C>A	c.(1282-1284)AAC>AAA	p.N428K	DTNA_uc010xbx.1_Intron|DTNA_uc002kxv.3_Missense_Mutation_p.N371K|DTNA_uc002kxw.2_Missense_Mutation_p.N371K|DTNA_uc010dmj.2_Missense_Mutation_p.N368K|DTNA_uc002kxz.2_Missense_Mutation_p.N368K|DTNA_uc002kxy.2_Missense_Mutation_p.N368K|DTNA_uc010dml.2_Missense_Mutation_p.N368K|DTNA_uc002kyb.3_Missense_Mutation_p.N425K|DTNA_uc010dmm.2_Missense_Mutation_p.N428K|DTNA_uc010xby.1_Missense_Mutation_p.N118K|DTNA_uc010dmo.2_Missense_Mutation_p.N50K|DTNA_uc002kyd.3_Missense_Mutation_p.N50K|DTNA_uc010xbz.1_Missense_Mutation_p.N137K|DTNA_uc010xca.1_Missense_Mutation_p.N80K|DTNA_uc002kye.2_Missense_Mutation_p.N76K	NM_001390	NP_001381	Q9Y4J8	DTNA_HUMAN	dystrobrevin alpha isoform 1	428	Syntrophin-binding region.				neuromuscular synaptic transmission|signal transduction|striated muscle contraction	cell junction|cytoplasm|synapse	calcium ion binding|protein binding|zinc ion binding				0						AGAGTTCAAACCGGCTTGATG	0.448		NA											19	14					4.35e-09	4.91e-09	1	0
ADAMTSL5	339366	broad.mit.edu	37	19	1506029	1506029	+	Silent	SNP	C	C	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr19:1506029C>T	uc002ltd.2	-	12	1845	c.1401G>A	c.(1399-1401)CGG>CGA	p.R467R	ADAMTSL5_uc010dsl.2_Silent_p.R236R|ADAMTSL5_uc010xgq.1_Silent_p.R477R	NM_213604	NP_998769	Q6ZMM2	ATL5_HUMAN	ADAMTS-like 5 precursor	467	NTR.					proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0		Acute lymphoblastic leukemia(61;5.61e-13)|all_hematologic(61;2.65e-08)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGGACAGCGCCGGGCAGTCA	0.672		NA											9	6					0	0	0	0
MUC16	94025	broad.mit.edu	37	19	9058238	9058238	+	Silent	SNP	C	C	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr19:9058238C>A	uc002mkp.2	-	3	29412	c.29208G>T	c.(29206-29208)ACG>ACT	p.T9736T		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	9738	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AAAGTGAGGTCGTGAGAGGTA	0.502		NA											15	23					0.00244969	0.00258168	1	0
OR7D4	125958	broad.mit.edu	37	19	9324922	9324922	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr19:9324922C>A	uc002mla.1	-	1	592	c.592G>T	c.(592-594)GTC>TTC	p.V198F		NM_001005191	NP_001005191	Q8NG98	OR7D4_HUMAN	olfactory receptor, family 7, subfamily D,	198	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4						ACATACAAGACAATGTTATTG	0.522		NA											14	85					6.32e-08	7.08e-08	1	0
SLC44A2	57153	broad.mit.edu	37	19	10738659	10738659	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr19:10738659G>A	uc002mpf.2	+	4	363	c.224G>A	c.(223-225)GGG>GAG	p.G75E	SLC44A2_uc002mpe.3_Missense_Mutation_p.G73E	NM_020428	NP_065161	Q8IWA5	CTL2_HUMAN	solute carrier family 44, member 2 isoform 1	75	Extracellular (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane|plasma membrane	choline transmembrane transporter activity|signal transducer activity			ovary(1)	1			Epithelial(33;8.7e-06)|all cancers(31;2.77e-05)		Choline(DB00122)	GAGTTCTGCGGGCAGAAGGGC	0.572		NA											12	12					0	0	0	0
ZNF799	90576	broad.mit.edu	37	19	12501389	12501389	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr19:12501389T>A	uc010dyt.2	-	4	1973	c.1823A>T	c.(1822-1824)AAG>ATG	p.K608M	ZNF799_uc002mts.3_Intron	NM_001080821	NP_001074290	Q96GE5	ZN799_HUMAN	zinc finger protein 799	608	C2H2-type 17.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|ovary(2)|skin(1)	6						CCAGTGAGTCTTTTTATGTCT	0.403		NA											54	96					0	0	0	0
UNC13A	23025	broad.mit.edu	37	19	17740103	17740103	+	Silent	SNP	T	T	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr19:17740103T>A	uc002nhd.2	-	31	3963	c.3963A>T	c.(3961-3963)GCA>GCT	p.A1321A		NM_001080421	NP_001073890	Q9UPW8	UN13A_HUMAN	unc-13 homolog A	1233	MHD1.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(3)	3						AGATGATGTCTGCATACTGGA	0.577		NA											8	15					0	0	0	0
ZNF93	81931	broad.mit.edu	37	19	20044894	20044894	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr19:20044894C>T	uc002non.2	+	4	1241	c.1130C>T	c.(1129-1131)GCC>GTC	p.A377V		NM_031218	NP_112495	P35789	ZNF93_HUMAN	zinc finger protein 93	377	C2H2-type 9.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			pancreas(1)	1						TGTGGCAAAGCCTTCATTTGG	0.393		NA											26	42					0	0	0	0
ZNF829	374899	broad.mit.edu	37	19	37398928	37398928	+	Splice_Site	SNP	T	T	C			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr19:37398928T>C	uc002ofa.1	-	5	586	c.224_splice	c.e5-1	p.G75_splice	ZNF345_uc002oez.2_Intron|ZNF829_uc002ofb.2_Intron	NM_001037232	NP_001032309	Q3KNS6	ZN829_HUMAN	zinc finger protein 829						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TGGAAAGTCCTGTTCACAAGA	0.468		NA											9	33					0	0	0	0
ZNF420	147923	broad.mit.edu	37	19	37618477	37618477	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr19:37618477A>G	uc002ofl.2	+	5	799	c.584A>G	c.(583-585)TAT>TGT	p.Y195C		NM_144689	NP_653290	Q8TAQ5	ZN420_HUMAN	zinc finger protein 420	195	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GAGAAACCCTATGCATGTAAG	0.388		NA											13	37					0	0	0	0
MAP4K1	11184	broad.mit.edu	37	19	39103266	39103266	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr19:39103266T>A	uc002oix.1	-	9	758	c.650A>T	c.(649-651)GAT>GTT	p.D217V	MAP4K1_uc002oiy.1_Missense_Mutation_p.D217V|MAP4K1_uc010xug.1_5'UTR	NM_007181	NP_009112	Q92918	M4K1_HUMAN	mitogen-activated protein kinase kinase kinase	217	Protein kinase.				activation of JUN kinase activity|peptidyl-serine phosphorylation		ATP binding|MAP kinase kinase kinase kinase activity|protein binding|small GTPase regulator activity			skin(4)|lung(3)|ovary(1)	8	all_cancers(60;6.42e-06)|Ovarian(47;0.103)		Lung(45;0.000751)|LUSC - Lung squamous cell carcinoma(53;0.00272)			AGGGTGCACATCAAAGAGCGG	0.627		NA											22	31					0	0	0	0
ZNF180	7733	broad.mit.edu	37	19	44981291	44981291	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr19:44981291T>A	uc002ozf.3	-	5	1689	c.1407A>T	c.(1405-1407)CAA>CAT	p.Q469H	ZNF180_uc002ozh.3_Missense_Mutation_p.Q126H|ZNF180_uc002ozi.3_Missense_Mutation_p.Q442H|ZNF180_uc002ozg.3_Missense_Mutation_p.Q468H|ZNF180_uc010ejm.2_Missense_Mutation_p.Q444H	NM_013256	NP_037388	Q9UJW8	ZN180_HUMAN	zinc finger protein 180	469	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Prostate(69;0.0435)				ATTTCCCACATTGATTACATT	0.368		NA											21	62					0	0	0	0
PRKCG	5582	broad.mit.edu	37	19	54396287	54396287	+	Silent	SNP	G	G	A	rs139506301		TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr19:54396287G>A	uc002qcq.1	+	8	1149	c.867G>A	c.(865-867)CCG>CCA	p.P289P	PRKCG_uc010eqz.1_Silent_p.P289P|PRKCG_uc010yef.1_Intron|PRKCG_uc010yeg.1_Silent_p.P289P|PRKCG_uc010yeh.1_Silent_p.P176P	NM_002739	NP_002730	P05129	KPCG_HUMAN	protein kinase C, gamma	289					activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			lung(4)|ovary(2)|pancreas(2)|large_intestine(1)	9	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		ACAATGTGCCGGTGGCCGATG	0.607		NA											4	23					0	0	0	0
ZNF71	58491	broad.mit.edu	37	19	57133988	57133988	+	Nonsense_Mutation	SNP	A	A	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr19:57133988A>T	uc002qnm.3	+	3	1571	c.1333A>T	c.(1333-1335)AAG>TAG	p.K445*		NM_021216	NP_067039	Q9NQZ8	ZNF71_HUMAN	zinc finger protein 71	445	C2H2-type 12.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1				GBM - Glioblastoma multiforme(193;0.062)|Lung(386;0.0681)|LUSC - Lung squamous cell carcinoma(496;0.18)		CCAGTGCGGGAAGTCCTTCAT	0.647		NA											17	24					0	0	0	0
ITSN2	50618	broad.mit.edu	37	2	24521568	24521568	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr2:24521568T>C	uc002rfe.2	-	13	1718	c.1460A>G	c.(1459-1461)AAA>AGA	p.K487R	ITSN2_uc002rff.2_Missense_Mutation_p.K487R|ITSN2_uc002rfg.2_Missense_Mutation_p.K487R|ITSN2_uc010eyd.2_Missense_Mutation_p.K512R	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1	487	Potential.				endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ATTCTTCTTTTTAGAGTTTAA	0.373		NA											30	74					0	0	0	0
EMILIN1	11117	broad.mit.edu	37	2	27303763	27303763	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr2:27303763C>T	uc002rii.3	+	3	882	c.454C>T	c.(454-456)CGC>TGC	p.R152C	EMILIN1_uc010eyq.1_Missense_Mutation_p.R152C|EMILIN1_uc002rik.3_5'Flank	NM_007046	NP_008977	Q9Y6C2	EMIL1_HUMAN	elastin microfibril interfacer 1 precursor	152					cell adhesion	collagen				pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCAGCCTGCCCGCCCCAACCT	0.667		NA									OREG0014513	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	10					0	0	0	0
IFT172	26160	broad.mit.edu	37	2	27706461	27706461	+	Silent	SNP	C	C	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr2:27706461C>T	uc002rku.2	-	6	519	c.468G>A	c.(466-468)GTG>GTA	p.V156V	IFT172_uc002rkw.2_Silent_p.V156V|IFT172_uc010yls.1_Silent_p.V135V|IFT172_uc010ezc.2_Silent_p.V156V|IFT172_uc002rkv.2_Silent_p.V156V	NM_015662	NP_056477	Q9UG01	IF172_HUMAN	selective LIM binding factor homolog	156	WD 4.				cilium assembly	cilium	binding			large_intestine(1)|ovary(1)	2	Acute lymphoblastic leukemia(172;0.155)					TTGTCAGGGACACCACGTAAG	0.403		NA											13	41					0	0	0	0
TRMT61B	55006	broad.mit.edu	37	2	29092865	29092865	+	Silent	SNP	C	C	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr2:29092865C>T	uc002rmm.2	-	1	311	c.279G>A	c.(277-279)CTG>CTA	p.L93L	TRMT61B_uc002rmn.2_Silent_p.L93L|TRMT61B_uc010ezk.2_RNA	NM_017910	NP_060380	Q9BVS5	TR61B_HUMAN	tRNA methyltransferase 61 homolog B	93							tRNA (adenine-N1-)-methyltransferase activity				0						ACTCTTCCCGCAGCGTCGGCA	0.612		NA											15	36					0	0	0	0
CIAO1	9391	broad.mit.edu	37	2	96933414	96933414	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr2:96933414G>A	uc002svs.2	+	3	545	c.340G>A	c.(340-342)GCC>ACC	p.A114T	TMEM127_uc002svq.2_5'Flank|TMEM127_uc002svr.2_5'Flank	NM_004804	NP_004795	O76071	CIAO1_HUMAN	WD repeat domain 39	114	WD 3.				chromosome segregation|iron-sulfur cluster assembly|positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter	MMXD complex	protein binding				0						AGTGGCTTGGGCCCCATCTGG	0.537		NA											4	14					0	0	0	0
SLC9A4	389015	broad.mit.edu	37	2	103125363	103125363	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr2:103125363G>T	uc002tbz.3	+	6	1916	c.1459G>T	c.(1459-1461)GAA>TAA	p.E487*		NM_001011552	NP_001011552	Q6AI14	SL9A4_HUMAN	solute carrier family 9 (sodium/hydrogen	487	Cytoplasmic (Potential).				regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			skin(2)|central_nervous_system(1)	3						CAATAAAAAAGAATCCATCAA	0.353		NA											18	57					3.99e-14	4.68e-14	1	0
NCK2	8440	broad.mit.edu	37	2	106497977	106497977	+	Silent	SNP	C	C	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr2:106497977C>T	uc002tdg.2	+	4	862	c.420C>T	c.(418-420)GTC>GTT	p.V140V	NCK2_uc002tdh.2_Intron|NCK2_uc002tdi.2_Silent_p.V140V	NM_003581	NP_003572	O43639	NCK2_HUMAN	NCK adaptor protein 2 isoform A	140	SH3 2.				axon guidance|epidermal growth factor receptor signaling pathway|negative regulation of cell proliferation|positive regulation of actin filament polymerization|positive regulation of T cell proliferation|regulation of epidermal growth factor receptor activity|regulation of translation|signal complex assembly|T cell activation	cytosol|endoplasmic reticulum	cytoskeletal adaptor activity|receptor signaling complex scaffold activity			ovary(1)|lung(1)	2						GCGTCACCGTCATGGAGAAGT	0.632		NA											39	49					0	0	0	0
LRP1B	53353	broad.mit.edu	37	2	141272305	141272306	+	Missense_Mutation	DNP	GC	GC	AA			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr2:141272305_141272306GC>AA	uc002tvj.1	-	51	9157_9158	c.8185_8186GC>TT	c.(8185-8187)GCA>TTA	p.A2729L		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2729	Extracellular (Potential).|LDL-receptor class A 16.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ACATTTTTGTGCGGAACAAGCA	0.342		NA								TSP Lung(27;0.18)			11	37					0	0	0	0
NEB	4703	broad.mit.edu	37	2	152398013	152398013	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr2:152398013G>T	uc010fnx.2	-	108	15718	c.15527C>A	c.(15526-15528)CCT>CAT	p.P5176H	NEB_uc002txr.2_Missense_Mutation_p.P1599H	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	5176	Nebulin 141.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		AGGAGTATCAGGAACTGAAGT	0.473		NA											19	81					7.21e-19	8.63e-19	1	0
RBMS1	5937	broad.mit.edu	37	2	161223852	161223852	+	Silent	SNP	G	G	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr2:161223852G>T	uc002ubo.2	-	2	570	c.126C>A	c.(124-126)ACC>ACA	p.T42T	RBMS1_uc002ubj.2_Silent_p.T9T|RBMS1_uc002ubk.2_Silent_p.T9T|RBMS1_uc002ubl.2_Silent_p.T40T|RBMS1_uc002ubn.2_Silent_p.T42T|RBMS1_uc002ubi.3_Silent_p.T42T|RBMS1_uc002ubm.2_Silent_p.T9T|RBMS1_uc002ubp.2_Silent_p.T42T|RBMS1_uc010fox.2_Silent_p.T42T	NM_016836	NP_058520	P29558	RBMS1_HUMAN	RNA binding motif, single stranded interacting	42					DNA replication|RNA processing	nucleus	double-stranded DNA binding|nucleotide binding|protein binding|RNA binding|single-stranded DNA binding				0						tattactgctggtggtgctgG	0.448		NA											14	44					1.05e-09	1.2e-09	1	0
TTC21B	79809	broad.mit.edu	37	2	166770094	166770094	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr2:166770094T>C	uc002udk.2	-	16	2334	c.2201A>G	c.(2200-2202)AAT>AGT	p.N734S		NM_024753	NP_079029	Q7Z4L5	TT21B_HUMAN	tetratricopeptide repeat domain 21B	734	TPR 9.					cilium axoneme|cytoplasm|cytoskeleton	binding			ovary(2)|pancreas(2)|breast(1)	5						CTCTAGAATATTCATGTATGC	0.313		NA											16	51					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179587395	179587395	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr2:179587395T>C	uc010zfg.1	-	73	18723	c.18499A>G	c.(18499-18501)AGA>GGA	p.R6167G	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.R2828G	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	7094							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCTTGAATTCTGAACACAGTC	0.323		NA											4	21					0	0	0	0
CCDC141	285025	broad.mit.edu	37	2	179736188	179736188	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr2:179736188C>T	uc002unf.1	-	4	503	c.446G>A	c.(445-447)CGA>CAA	p.R149Q		NM_173648	NP_775919	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	149							protein binding			ovary(7)|pancreas(2)|skin(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			CCATTTTTGTCGTAGATCTAA	0.393		NA											33	162					0	0	0	0
SESTD1	91404	broad.mit.edu	37	2	180036936	180036936	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr2:180036936G>A	uc002uni.3	-	5	430	c.280C>T	c.(280-282)CTT>TTT	p.L94F		NM_178123	NP_835224	Q86VW0	SESD1_HUMAN	SEC14 and spectrin domains 1	94	CRAL-TRIO.				regulation of calcium ion transport via voltage-gated calcium channel activity		phosphatidic acid binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding|protein binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0344)|Epithelial(96;0.0531)|all cancers(119;0.147)			ACACAAACAAGGGACACCTCA	0.308		NA											20	58					0	0	0	0
ERBB4	2066	broad.mit.edu	37	2	212251875	212251875	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr2:212251875T>G	uc002veg.1	-	27	3282	c.3184A>C	c.(3184-3186)AAC>CAC	p.N1062H	ERBB4_uc002veh.1_Missense_Mutation_p.N1046H|ERBB4_uc010zji.1_Missense_Mutation_p.N1052H|ERBB4_uc010zjj.1_Missense_Mutation_p.N1036H	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	1062	Cytoplasmic (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		ACAAACTGGTTCTGTTAATAA	0.423		NA								TSP Lung(8;0.080)			31	70					0	0	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3673192	3673192	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr20:3673192G>A	uc002wja.2	-	15	4006	c.4006C>T	c.(4006-4008)CGT>TGT	p.R1336C	SIGLEC1_uc002wjb.1_5'UTR|SIGLEC1_uc002wiz.3_Missense_Mutation_p.R1336C	NM_023068	NP_075556	Q9BZZ2	SN_HUMAN	sialoadhesin precursor	1336	Ig-like C2-type 13.|Extracellular (Potential).				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			pancreas(4)|ovary(2)|skin(2)|breast(1)|central_nervous_system(1)	10						GCAGCAGGACGGGAGCTGCGG	0.682		NA											5	14					0	0	0	0
C20orf103	24141	broad.mit.edu	37	20	9498787	9498787	+	Silent	SNP	T	T	C			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr20:9498787T>C	uc002wni.1	+	5	805	c.576T>C	c.(574-576)TCT>TCC	p.S192S	C20orf103_uc010zrc.1_Silent_p.S148S	NM_012261	NP_036393	Q9UJQ1	CT103_HUMAN	chromosome 20 open reading frame 103 precursor	192	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|lung(1)|breast(1)	3			COAD - Colon adenocarcinoma(9;0.194)			CACTGGCCTCTAGTGATCCGC	0.512		NA											16	34					0	0	0	0
FOXA2	3170	broad.mit.edu	37	20	22563619	22563619	+	Silent	SNP	G	G	C			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr20:22563619G>C	uc002wsn.2	-	3	433	c.243C>G	c.(241-243)TCC>TCG	p.S81S	FOXA2_uc002wsm.2_Silent_p.S87S	NM_153675	NP_710141	Q9Y261	FOXA2_HUMAN	forkhead box A2 isoform 2	81	Transactivation domain 1 (By similarity).				cell differentiation in hindbrain|central nervous system myelin formation|chromatin modification|dorsal/ventral neural tube patterning|ectoderm formation|endocrine pancreas development|endoderm development|epithelial tube branching involved in lung morphogenesis|in utero embryonic development|lung epithelial cell differentiation|negative regulation of neuron differentiation|neuron fate specification|oligodendrocyte cell fate commitment|positive regulation of embryonic development|positive regulation of gastrulation|positive regulation of neuron differentiation|primitive streak formation|regulation of blood coagulation|regulation of sequence-specific DNA binding transcription factor activity|response to interleukin-6	cytoplasm|transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)|kidney(1)|central_nervous_system(1)	4	Lung NSC(19;0.188)					CCGCGCCGGGGGACATCCCCG	0.766		NA											19	37					0	0	0	0
CDK5RAP1	51654	broad.mit.edu	37	20	31967483	31967483	+	Silent	SNP	C	C	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr20:31967483C>T	uc010gek.2	-	9	1057	c.933G>A	c.(931-933)GTG>GTA	p.V311V	CDK5RAP1_uc002wyy.2_Silent_p.V207V|CDK5RAP1_uc002wyz.2_Silent_p.V297V|CDK5RAP1_uc002wza.2_Silent_p.V297V|CDK5RAP1_uc010gel.2_Silent_p.V206V|CDK5RAP1_uc010gem.2_Intron|CDK5RAP1_uc002wzc.1_Silent_p.V297V	NM_016408	NP_057492	Q96SZ6	CK5P1_HUMAN	CDK5 regulatory subunit associated protein 1	311					brain development|negative regulation of cyclin-dependent protein kinase activity|regulation of neuron differentiation|tRNA modification	cytoplasm	4 iron, 4 sulfur cluster binding|metal ion binding|neuronal Cdc2-like kinase binding|transferase activity			ovary(2)|skin(2)|lung(1)	5						CAAGAAGTGTCACTTCTTTCA	0.368		NA											8	58					0	0	0	0
CDK5RAP1	51654	broad.mit.edu	37	20	31967498	31967498	+	Splice_Site	SNP	C	C	G			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr20:31967498C>G	uc010gek.2	-	9	1043	c.919_splice	c.e9-1	p.G307_splice	CDK5RAP1_uc002wyy.2_Splice_Site_p.G203_splice|CDK5RAP1_uc002wyz.2_Splice_Site_p.G293_splice|CDK5RAP1_uc002wza.2_Splice_Site_p.G293_splice|CDK5RAP1_uc010gel.2_Splice_Site_p.G202_splice|CDK5RAP1_uc010gem.2_Intron|CDK5RAP1_uc002wzc.1_Splice_Site_p.G293_splice	NM_016408	NP_057492	Q96SZ6	CK5P1_HUMAN	CDK5 regulatory subunit associated protein 1						brain development|negative regulation of cyclin-dependent protein kinase activity|regulation of neuron differentiation|tRNA modification	cytoplasm	4 iron, 4 sulfur cluster binding|metal ion binding|neuronal Cdc2-like kinase binding|transferase activity			ovary(2)|skin(2)|lung(1)	5						CTTTCAGCCCCTAAACATGGG	0.343		NA											7	51					0	0	0	0
GDF5	8200	broad.mit.edu	37	20	34021968	34021968	+	Silent	SNP	G	G	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr20:34021968G>A	uc010gfc.1	-	2	1486	c.1245C>T	c.(1243-1245)GAC>GAT	p.D415D	uc002xcj.2_Missense_Mutation_p.V127I|GDF5_uc002xck.1_Silent_p.D415D|GDF5_uc010zvc.1_Silent_p.D415D	NM_000557	NP_000548	P43026	GDF5_HUMAN	growth differentiation factor 5 preproprotein	415					cartilage development|cell-cell signaling|growth|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity				0	Lung NSC(9;0.00642)|all_lung(11;0.0094)		BRCA - Breast invasive adenocarcinoma(18;0.00663)			TGATCCAGTCGTCCCAGCCCA	0.607		NA											128	58					0	0	0	0
ZBTB46	140685	broad.mit.edu	37	20	62378483	62378483	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr20:62378483G>C	uc002ygv.1	-	5	1771	c.1570C>G	c.(1570-1572)CCA>GCA	p.P524A	ZBTB46_uc002ygu.2_RNA	NM_025224	NP_079500	Q86UZ6	ZBT46_HUMAN	zinc finger and BTB domain containing 46	524					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			large_intestine(1)|ovary(1)	2	all_cancers(38;2.09e-12)|all_epithelial(29;3.8e-14)|Lung NSC(23;7.61e-10)|all_lung(23;2.64e-09)					AGCGCCTCTGGAGAGCCCTCG	0.736		NA											5	13					0	0	0	0
KRTAP15-1	254950	broad.mit.edu	37	21	31812926	31812926	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr21:31812926C>T	uc002yod.2	+	1	281	c.281C>T	c.(280-282)TCC>TTC	p.S94F		NM_181623	NP_853654	Q3LI76	KR151_HUMAN	keratin associated protein 15-1	94						intermediate filament					0						TACATAAGATCCCTTGGATGT	0.502		NA											12	86					0	0	0	0
POFUT2	23275	broad.mit.edu	37	21	46685544	46685544	+	Silent	SNP	A	A	G			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr21:46685544A>G	uc002zhc.2	-	9	1168	c.1143T>C	c.(1141-1143)TTT>TTC	p.F381F	POFUT2_uc002zha.2_RNA|POFUT2_uc002zhb.2_RNA|POFUT2_uc002zhd.2_3'UTR	NM_133635	NP_598368	Q9Y2G5	OFUT2_HUMAN	protein O-fucosyltransferase 2 isoform C	381					fucose metabolic process	endoplasmic reticulum	peptide-O-fucosyltransferase activity				0				Colorectal(79;0.243)		AGGTGCCAATAAAAAACCTGC	0.498		NA											12	13					0	0	0	0
MYO18B	84700	broad.mit.edu	37	22	26317306	26317306	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr22:26317306T>C	uc003abz.1	+	34	5697	c.5447T>C	c.(5446-5448)CTC>CCC	p.L1816P	MYO18B_uc003aca.1_Missense_Mutation_p.L1697P|MYO18B_uc010guy.1_Missense_Mutation_p.L1698P|MYO18B_uc010guz.1_Missense_Mutation_p.L1696P|MYO18B_uc011aka.1_Missense_Mutation_p.L970P|MYO18B_uc011akb.1_Missense_Mutation_p.L1329P	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1816	Tail.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						GACGTGCAGCTCCTTCTGGGC	0.552		NA											6	1					0	0	0	0
TPST2	8459	broad.mit.edu	37	22	26937142	26937142	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr22:26937142G>C	uc003acv.2	-	2	623	c.455C>G	c.(454-456)GCC>GGC	p.A152G	TPST2_uc003acw.2_Missense_Mutation_p.A152G|TPST2_uc003acx.2_Missense_Mutation_p.A152G|TPST2_uc011akf.1_Missense_Mutation_p.A152G	NM_003595	NP_003586	O60704	TPST2_HUMAN	tyrosylprotein sulfotransferase 2	152	Lumenal (Potential).				peptidyl-tyrosine sulfation	endoplasmic reticulum|Golgi membrane|integral to membrane|membrane fraction	protein-tyrosine sulfotransferase activity			central_nervous_system(1)	1						GAGCACGCGGGCCGGCTCTCC	0.637		NA											26	47					0	0	0	0
KREMEN1	83999	broad.mit.edu	37	22	29490261	29490261	+	Missense_Mutation	SNP	A	A	G	rs35199515		TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr22:29490261A>G	uc011akm.1	+	2	126	c.113A>G	c.(112-114)AAT>AGT	p.N38S	KREMEN1_uc003ael.2_Missense_Mutation_p.N38S|KREMEN1_uc011akn.1_5'UTR	NM_032045	NP_114434	Q96MU8	KREM1_HUMAN	kringle-containing transmembrane protein 1	36	Extracellular (Potential).|Kringle.				cell communication|regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane|membrane fraction	protein binding			ovary(3)|lung(2)	5						TTCACAGCCAATGGTGCGGAT	0.428		NA											36	56					0	0	0	0
SMCR7L	54471	broad.mit.edu	37	22	39908272	39908272	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr22:39908272A>T	uc003axx.2	+	5	856	c.358A>T	c.(358-360)AGG>TGG	p.R120W	SMCR7L_uc003axw.2_Missense_Mutation_p.R120W|SMCR7L_uc010gxz.1_Intron|SMCR7L_uc003axy.2_Intron	NM_019008	NP_061881	Q9NQG6	SMC7L_HUMAN	hypothetical protein LOC54471	120						integral to membrane|mitochondrion				central_nervous_system(1)	1	Melanoma(58;0.04)					GCCAGTGGCCAGGAAGGGCCA	0.597		NA											24	32					0	0	0	0
CACNA1I	8911	broad.mit.edu	37	22	40060149	40060149	+	Silent	SNP	C	C	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr22:40060149C>T	uc003ayc.2	+	20	3651	c.3651C>T	c.(3649-3651)GGC>GGT	p.G1217G	CACNA1I_uc003ayd.2_Silent_p.G1182G|CACNA1I_uc003aye.2_Silent_p.G1132G|CACNA1I_uc003ayf.2_Silent_p.G1097G	NM_021096	NP_066919	Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type,	1217	Helical; Name=S2 of repeat III; (Potential).|III.				axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(1)|central_nervous_system(1)	2	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	TCTTCGTGGGCGAGATGACAT	0.612		NA											6	19					0	0	0	0
ZC3H7B	23264	broad.mit.edu	37	22	41753426	41753426	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr22:41753426G>T	uc003azw.2	+	23	3143	c.2927G>T	c.(2926-2928)GGG>GTG	p.G976V	ZC3H7B_uc010gyl.1_Intron	NM_017590	NP_060060	Q9UGR2	Z3H7B_HUMAN	zinc finger CCCH-type containing 7B	992					interspecies interaction between organisms	nucleus	nucleic acid binding|protein binding|zinc ion binding			central_nervous_system(1)	1						GCCACCACTGGGGAGTAGGGC	0.662		NA											40	75					1.47e-25	1.78e-25	1	0
MRPS25	64432	broad.mit.edu	37	3	15100956	15100956	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr3:15100956T>A	uc003bzl.2	-	2	276	c.161A>T	c.(160-162)CAG>CTG	p.Q54L	MRPS25_uc011avl.1_Missense_Mutation_p.Q54L|MRPS25_uc011avm.1_Missense_Mutation_p.Q54L	NM_022497	NP_071942	P82663	RT25_HUMAN	mitochondrial ribosomal protein S25	54					translation	mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome				0						GTATTGAATCTGAGGTATGTT	0.383		NA											5	11					0	0	0	0
PTPN23	25930	broad.mit.edu	37	3	47450995	47450995	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr3:47450995C>T	uc003crf.1	+	18	1982	c.1886C>T	c.(1885-1887)GCA>GTA	p.A629V	PTPN23_uc011baw.1_Missense_Mutation_p.A594V|PTPN23_uc011bax.1_RNA|PTPN23_uc011bay.1_Missense_Mutation_p.A499V	NM_015466	NP_056281	Q9H3S7	PTN23_HUMAN	protein tyrosine phosphatase, non-receptor type	629					cilium morphogenesis	cilium|cytoplasmic membrane-bounded vesicle|microtubule basal body	protein tyrosine phosphatase activity			breast(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000271)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GTCCTCTGTGCACTGACAGAG	0.597		NA											20	3					0	0	0	0
FAM19A4	151647	broad.mit.edu	37	3	68802098	68802098	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr3:68802098C>T	uc003dnh.1	-	4	645	c.202G>A	c.(202-204)GAA>AAA	p.E68K	FAM19A4_uc003dni.1_Missense_Mutation_p.E68K	NM_182522	NP_872328	Q96LR4	F19A4_HUMAN	family with sequence similarity 19 (chemokine	68						extracellular region				skin(2)	2		Lung NSC(201;0.0198)		BRCA - Breast invasive adenocarcinoma(55;1.38e-05)|Epithelial(33;0.000124)|LUSC - Lung squamous cell carcinoma(21;0.0248)|KIRC - Kidney renal clear cell carcinoma(39;0.0729)|Kidney(39;0.0904)		GACCGCTCTTCTATGCGGTTC	0.537		NA											21	25					0	0	0	0
ARL6	84100	broad.mit.edu	37	3	97503853	97503853	+	Silent	SNP	T	T	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr3:97503853T>A	uc003drv.2	+	6	622	c.309T>A	c.(307-309)GTT>GTA	p.V103V	ARL6_uc003drw.2_RNA|ARL6_uc003dru.2_Silent_p.V103V|ARL6_uc010hoy.2_Silent_p.V103V	NM_177976	NP_816931	Q9H0F7	ARL6_HUMAN	ADP-ribosylation factor-like 6	103					cilium assembly|determination of left/right symmetry|melanosome transport|protein polymerization|protein targeting to membrane|small GTPase mediated signal transduction|visual perception|Wnt receptor signaling pathway	axonemal microtubule|cilium axoneme|cilium membrane|membrane coat|microtubule basal body	GTP binding|metal ion binding|phospholipid binding|protein binding				0		Lung NSC(201;0.0193)|Prostate(884;0.174)		LUSC - Lung squamous cell carcinoma(29;0.0118)|Lung(72;0.0189)		TAAGAATGGTTGTGGCCAAAG	0.323		NA							Bardet-Biedl_syndrome				28	24					0	0	0	0
FAM55C	91775	broad.mit.edu	37	3	101535759	101535759	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr3:101535759C>G	uc003dvn.2	+	7	1680	c.1043C>G	c.(1042-1044)ACA>AGA	p.T348R	FAM55C_uc010hpn.2_Missense_Mutation_p.T348R	NM_145037	NP_659474	Q969Y0	FA55C_HUMAN	hypothetical protein LOC91775 precursor	348						extracellular region				ovary(1)|pancreas(1)|skin(1)	3						GACAACATTACAGAGTGCTTA	0.408		NA											29	113					0	0	0	0
UROC1	131669	broad.mit.edu	37	3	126219567	126219567	+	Silent	SNP	A	A	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr3:126219567A>T	uc003eiz.1	-	11	1148	c.1116T>A	c.(1114-1116)CCT>CCA	p.P372P	UROC1_uc010hsi.1_Silent_p.P432P	NM_144639	NP_653240	Q96N76	HUTU_HUMAN	urocanase domain containing 1 isoform 1	372					histidine catabolic process	cytosol	urocanate hydratase activity			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.17)		TGAACACAGCAGGGTTGGAGG	0.597		NA											29	113					0	0	0	0
COL6A6	131873	broad.mit.edu	37	3	130293063	130293063	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr3:130293063G>T	uc010htl.2	+	7	3272	c.3241G>T	c.(3241-3243)GCT>TCT	p.A1081S		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	1081	Nonhelical region.|VWFA 6.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						ACACATCGGTGCTGCACTCAG	0.478		NA											12	60					9.31e-06	1.01e-05	1	0
SIAH2	6478	broad.mit.edu	37	3	150460290	150460290	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr3:150460290A>T	uc003eyi.2	-	2	1240	c.613T>A	c.(613-615)TTT>ATT	p.F205I		NM_005067	NP_005058	O43255	SIAH2_HUMAN	seven in absentia homolog 2	205	SBD.				apoptosis|axon guidance|cell cycle|negative regulation of canonical Wnt receptor signaling pathway|small GTPase mediated signal transduction|ubiquitin-dependent protein catabolic process	cytosol|nucleus	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)	2			LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			GTAGCTAGAAAGACGATGTCT	0.522		NA											15	61					0	0	0	0
PPM1L	151742	broad.mit.edu	37	3	160474321	160474321	+	Silent	SNP	T	T	C			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr3:160474321T>C	uc003fdr.2	+	1	326	c.225T>C	c.(223-225)CTT>CTC	p.L75L		NM_139245	NP_640338	Q5SGD2	PPM1L_HUMAN	protein phosphatase 1 (formerly 2C)-like	75	Cytoplasmic (Potential).				protein dephosphorylation|sphingolipid metabolic process	endoplasmic reticulum membrane|integral to membrane|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			breast(1)	1			Lung(72;0.00149)|LUSC - Lung squamous cell carcinoma(72;0.00216)			TCGGGGGGCTTGATGTGCTCG	0.597		NA											3	32					0	0	0	0
SLITRK3	22865	broad.mit.edu	37	3	164907251	164907251	+	Silent	SNP	G	G	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr3:164907251G>T	uc003fej.3	-	2	1812	c.1368C>A	c.(1366-1368)CCC>CCA	p.P456P	SLITRK3_uc003fek.2_Silent_p.P456P	NM_014926	NP_055741	O94933	SLIK3_HUMAN	slit and trk like 3 protein precursor	456	Extracellular (Potential).					integral to membrane				ovary(6)|skin(3)|pancreas(1)	10						TCTTTAAGTTGGGCAAGTTGA	0.428		NA								HNSCC(40;0.11)			9	35					3.1e-07	3.44e-07	1	0
PLD1	5337	broad.mit.edu	37	3	171394568	171394568	+	Silent	SNP	T	T	G			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr3:171394568T>G	uc003fhs.2	-	18	2168	c.2052A>C	c.(2050-2052)GCA>GCC	p.A684A	PLD1_uc003fht.2_Silent_p.A646A|PLD1_uc003fhu.3_5'Flank|PLD1_uc003fhv.1_Silent_p.A9A	NM_002662	NP_002653	Q13393	PLD1_HUMAN	phospholipase D1 isoform a	684	Catalytic.				cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			ovary(2)|lung(1)	3	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)	TCCCGTGGACTGCAGAGGCAA	0.517		NA											8	33					0	0	0	0
PIK3CA	5290	broad.mit.edu	37	3	178952085	178952085	+	Missense_Mutation	SNP	A	A	G	rs121913279		TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr3:178952085A>G	uc003fjk.2	+	21	3297	c.3140A>G	c.(3139-3141)CAT>CGT	p.H1047R		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	1047	PI3K/PI4K.		H -> L (in cancer).|H -> R (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; requires binding to p85 regulatory subunit to induce cellular transformation but not interaction with RAS; may mimic the conformatitonal change triggered by the interaction with RAS; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells; increases lipid kinase activity; may alter the interaction of the PI3K/ PI4K kinase domain with the cell membrane).|H -> Y (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.H1047R(1269)|p.H1047L(152)|p.H1047Y(31)|p.H1047Q(3)|p.H1047T(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AATGATGCACATCATGGTGGC	0.378	H1047R(BT20_BREAST)|H1047R(NCIH1048_LUNG)|H1047R(MCAS_OVARY)|H1047R(HCC1954_BREAST)|H1047R(RKO_LARGE_INTESTINE)|H1047L(EFM19_BREAST)|H1047R(CAL33_UPPER_AERODIGESTIVE_TRACT)|H1047R(CAL29_URINARY_TRACT)|H1047R(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|H1047R(LS180_LARGE_INTESTINE)|H1047R(T47D_BREAST)|H1047R(HCT116_LARGE_INTESTINE)|H1047R(HSC2_UPPER_AERODIGESTIVE_TRACT)|H1047R(SKOV3_OVARY)|H1047R(MDAMB453_BREAST)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			26	27					0	0	0	0
PARL	55486	broad.mit.edu	37	3	183547407	183547407	+	Silent	SNP	T	T	C			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr3:183547407T>C	uc003fmd.2	-	10	1178	c.1119A>G	c.(1117-1119)AAA>AAG	p.K373K	PARL_uc003fme.2_Silent_p.K323K	NM_018622	NP_061092	Q9H300	PARL_HUMAN	presenilin associated, rhomboid-like isoform 1	373	Mitochondrial intermembrane (Potential).				proteolysis	integral to membrane|mitochondrial inner membrane|nucleus	serine-type endopeptidase activity				0	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.21e-41)|Epithelial(37;1.34e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			CACCTCCTTTTTTGGGGCCAT	0.488		NA											67	182					0	0	0	0
CD38	952	broad.mit.edu	37	4	15835919	15835919	+	Silent	SNP	C	C	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr4:15835919C>A	uc011bxc.1	+	4	686	c.579C>A	c.(577-579)TCC>TCA	p.S193S	CD38_uc003gol.1_Silent_p.S193S	NM_001775	NP_001766	P28907	CD38_HUMAN	CD38 antigen	193	Extracellular (Potential).				B cell receptor signaling pathway|induction of apoptosis by extracellular signals|negative regulation of apoptosis|negative regulation of transcription, DNA-dependent|positive regulation of B cell proliferation|positive regulation of transcription, DNA-dependent|response to drug	integral to membrane|plasma membrane	binding|NAD+ nucleosidase activity|receptor activity			ovary(2)	2						AAACGGTTTCCCGCAGGGTAA	0.368		NA											9	30					0.000274275	0.000292202	1	0
GABRG1	2565	broad.mit.edu	37	4	46067515	46067515	+	Missense_Mutation	SNP	G	G	T	rs144076673		TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr4:46067515G>T	uc003gxb.2	-	4	560	c.408C>A	c.(406-408)AAC>AAA	p.N136K		NM_173536	NP_775807	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid A receptor, gamma 1	136	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(2)	2				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		CCATATTACTGTTAAGCATAA	0.328		NA											7	36					5.18e-06	5.67e-06	1	0
CORIN	10699	broad.mit.edu	37	4	47667085	47667085	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr4:47667085C>T	uc003gxm.2	-	11	1646	c.1553G>A	c.(1552-1554)TGT>TAT	p.C518Y	CORIN_uc011bzf.1_Missense_Mutation_p.C379Y|CORIN_uc011bzg.1_Missense_Mutation_p.C451Y|CORIN_uc011bzh.1_Missense_Mutation_p.C481Y|CORIN_uc011bzi.1_Missense_Mutation_p.C481Y	NM_006587	NP_006578	Q9Y5Q5	CORIN_HUMAN	corin	518	Extracellular (Potential).|FZ 2.				peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			ovary(1)|central_nervous_system(1)	2						ATTCACATCACATTTTGGTAC	0.443		NA											17	44					0	0	0	0
BDH2	56898	broad.mit.edu	37	4	104016422	104016422	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr4:104016422C>A	uc003hwz.2	-	3	194	c.89G>T	c.(88-90)GGT>GTT	p.G30V	BDH2_uc003hxa.2_RNA	NM_020139	NP_064524	Q9BUT1	BDH2_HUMAN	3-hydroxybutyrate dehydrogenase, type 2	30	NAD.				fatty acid beta-oxidation|heme metabolic process|iron ion homeostasis|siderophore biosynthetic process	cytoplasm	3-hydroxybutyrate dehydrogenase activity|NAD binding|oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor				0		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.02e-08)		GACTTTGGCACCTTCTCTTGC	0.403		NA											24	36					1.64e-13	1.92e-13	1	0
C4orf21	55345	broad.mit.edu	37	4	113553143	113553143	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr4:113553143C>T	uc003iau.2	-	3	256	c.45G>A	c.(43-45)ATG>ATA	p.M15I	C4orf21_uc003iaw.2_Missense_Mutation_p.M15I	NM_018392	NP_060862	Q6ZU11	YD002_HUMAN	prematurely terminated mRNA decay factor-like	Error:Variant_position_missing_in_Q6ZU11_after_alignment						integral to membrane	zinc ion binding				0		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		TTGACTTCTTCATCTTTTGAT	0.308		NA											26	10					0	0	0	0
PCDH10	57575	broad.mit.edu	37	4	134084195	134084195	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr4:134084195G>A	uc003iha.2	+	4	3687	c.2861G>A	c.(2860-2862)TGG>TAG	p.W954*		NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	954	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		GATCGGTGCTGGATGCCTTCT	0.488		NA											34	26					0	0	0	0
SLC6A3	6531	broad.mit.edu	37	5	1432743	1432743	+	Silent	SNP	C	C	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr5:1432743C>A	uc003jck.2	-	4	610	c.489G>T	c.(487-489)GCG>GCT	p.A163A		NM_001044	NP_001035	Q01959	SC6A3_HUMAN	solute carrier family 6 (neurotransmitter	163	Extracellular (Potential).				cell death|neurotransmitter biosynthetic process	axon|cytoplasm|integral to plasma membrane|neuronal cell body				ovary(3)|breast(2)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(19;0.00928)|all cancers(22;0.0262)		Amphetamine(DB00182)|Benztropine(DB00245)|Bupropion(DB01156)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dextroamphetamine(DB01576)|Diethylpropion(DB00937)|Duloxetine(DB00476)|Fencamfamine(DB01463)|Mazindol(DB00579)|Methylphenidate(DB00422)|Modafinil(DB00745)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Procaine(DB00721)	GATAGTGCAGCGCCCAGGCGA	0.587		NA											8	22					5.18e-06	5.67e-06	1	0
CTNND2	1501	broad.mit.edu	37	5	11565110	11565110	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr5:11565110C>T	uc003jfa.1	-	3	378	c.233G>A	c.(232-234)AGC>AAC	p.S78N	CTNND2_uc010itt.2_5'UTR|CTNND2_uc011cmy.1_5'UTR|CTNND2_uc011cmz.1_5'UTR|CTNND2_uc010itu.1_RNA	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	78	Potential.				multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						CTCCAGCTGGCTGGCTACGAT	0.517		NA											16	15					0	0	0	0
MYO10	4651	broad.mit.edu	37	5	16877787	16877787	+	Silent	SNP	G	G	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr5:16877787G>T	uc003jft.3	-	2	519	c.51C>A	c.(49-51)GGC>GGA	p.G17G	MYO10_uc003jfu.2_Intron|MYO10_uc003jfv.2_Silent_p.G17G	NM_012334	NP_036466	Q9HD67	MYO10_HUMAN	myosin X	17	Myosin head-like.				axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			ovary(2)|pancreas(1)	3						GAAAATGCTGGCCATTTTCTC	0.458		NA											12	20					2.81e-09	3.18e-09	1	0
PRDM9	56979	broad.mit.edu	37	5	23526849	23526850	+	Missense_Mutation	DNP	TC	TC	AT			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr5:23526849_23526850TC>AT	uc003jgo.2	+	11	1834_1835	c.1652_1653TC>AT	c.(1651-1653)CTC>CAT	p.L551H		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	551					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						GGGGAGAAGCTCTACGTCTGCA	0.485		NA								HNSCC(3;0.000094)			32	58					0	0	0	0
CDH6	1004	broad.mit.edu	37	5	31294222	31294222	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr5:31294222G>T	uc003jhe.1	+	3	708	c.382G>T	c.(382-384)GCT>TCT	p.A128S	CDH6_uc003jhd.1_Missense_Mutation_p.A128S	NM_004932	NP_004923	P55285	CADH6_HUMAN	cadherin 6, type 2 preproprotein	128	Extracellular (Potential).|Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			ovary(4)|skin(2)|large_intestine(1)	7						CATCCTTCGAGCTCAAGCTAT	0.453		NA											24	117					3.8e-18	4.52e-18	1	0
RXFP3	51289	broad.mit.edu	37	5	33937766	33937766	+	Silent	SNP	G	G	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr5:33937766G>A	uc003jic.1	+	1	1278	c.921G>A	c.(919-921)GCG>GCA	p.A307A		NM_016568	NP_057652	Q9NSD7	RL3R1_HUMAN	relaxin/insulin-like family peptide receptor 3	307	Cytoplasmic (Potential).					integral to plasma membrane	N-formyl peptide receptor activity			upper_aerodigestive_tract(1)	1						GAGGGGCCGCGGTAGCCGGAG	0.652		NA											6	7					0	0	0	0
WDR70	55100	broad.mit.edu	37	5	37605263	37605263	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr5:37605263A>T	uc003jkv.2	+	10	1073	c.1015A>T	c.(1015-1017)ACA>TCA	p.T339S	WDR70_uc010iva.1_Missense_Mutation_p.T339S	NM_018034	NP_060504	Q9NW82	WDR70_HUMAN	WD repeat domain 70	339	WD 4.									ovary(1)|central_nervous_system(1)	2	all_lung(31;0.000285)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CACTACGTGCACATATAGTAG	0.418		NA											21	54					0	0	0	0
COL4A3BP	10087	broad.mit.edu	37	5	74722212	74722212	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr5:74722212G>C	uc011csu.1	-	4	862	c.440C>G	c.(439-441)TCC>TGC	p.S147C	COL4A3BP_uc003kds.2_Missense_Mutation_p.S147C|COL4A3BP_uc003kdt.2_Missense_Mutation_p.S275C|COL4A3BP_uc003kdu.2_Missense_Mutation_p.S147C	NM_005713	NP_005704	Q9Y5P4	C43BP_HUMAN	alpha 3 type IV collagen binding protein isoform	147					ER to Golgi ceramide transport|immune response	cytosol|endoplasmic reticulum membrane|Golgi apparatus	ceramide binding|phosphatidylinositol-4-phosphate binding|protein binding|protein kinase activity			skin(1)	1		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Prostate(461;0.174)		OV - Ovarian serous cystadenocarcinoma(47;1e-53)		TGAAGAGGTGGATGTTGCAGA	0.398		NA											9	31					0	0	0	0
IQGAP2	10788	broad.mit.edu	37	5	75886317	75886317	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr5:75886317C>T	uc003kek.2	+	8	947	c.725C>T	c.(724-726)GCG>GTG	p.A242V		NM_006633	NP_006624	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	242					small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			ovary(6)|central_nervous_system(1)	7		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		AACCCAAATGCGGTTTTAACT	0.378		NA											28	25					0	0	0	0
PCDHA7	56141	broad.mit.edu	37	5	140215095	140215095	+	Missense_Mutation	SNP	A	A	T	rs145294768		TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr5:140215095A>T	uc003lhq.2	+	1	1127	c.1127A>T	c.(1126-1128)GAC>GTC	p.D376V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Missense_Mutation_p.D376V	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	376	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCGTGTTTGACCGAGATTTT	0.502		NA											24	61					0	0	0	0
PCDHA7	56141	broad.mit.edu	37	5	140215144	140215144	+	Silent	SNP	C	C	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr5:140215144C>T	uc003lhq.2	+	1	1176	c.1176C>T	c.(1174-1176)CGC>CGT	p.R392R	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Silent_p.R392R	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	392	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGACGCCCCGCGTTCCCTTCA	0.537		NA											27	88					0	0	0	0
PCDHB6	56130	broad.mit.edu	37	5	140530019	140530019	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr5:140530019C>T	uc003lir.2	+	1	181	c.181C>T	c.(181-183)CGG>TGG	p.R61W	PCDHB6_uc011dah.1_Intron	NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	protocadherin beta 6 precursor	61	Extracellular (Potential).|Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCTGGCTTCGCGGGGCGCTCG	0.507		NA											24	51					0	0	0	0
DIAPH1	1729	broad.mit.edu	37	5	140908052	140908052	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr5:140908052T>A	uc003llb.3	-	24	3257	c.3116A>T	c.(3115-3117)GAC>GTC	p.D1039V	DIAPH1_uc011dbd.1_5'Flank|DIAPH1_uc003llc.3_Missense_Mutation_p.D1030V|DIAPH1_uc010jgc.1_Missense_Mutation_p.D475V	NM_005219	NP_005210	O60610	DIAP1_HUMAN	diaphanous 1 isoform 1	1039	Potential.|FH2.				regulation of microtubule-based process|sensory perception of sound	cytoplasm|cytoskeleton|ruffle membrane	actin binding|receptor binding|Rho GTPase binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCAAGCTCGTCTGGAAACTT	0.498		NA											22	17					0	0	0	0
PCDH12	51294	broad.mit.edu	37	5	141336084	141336084	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr5:141336084G>A	uc003llx.2	-	1	2544	c.1333C>T	c.(1333-1335)CAG>TAG	p.Q445*		NM_016580	NP_057664	Q9NPG4	PCD12_HUMAN	protocadherin 12 precursor	445	Cadherin 4.|Extracellular (Potential).				neuron recognition	integral to plasma membrane	calcium ion binding			ovary(3)	3		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGCTGAGCTGTTTCTTGGCT	0.488		NA											32	70					0	0	0	0
LARS	51520	broad.mit.edu	37	5	145506097	145506097	+	Silent	SNP	T	T	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr5:145506097T>A	uc003lnx.1	-	28	3130	c.2892A>T	c.(2890-2892)GGA>GGT	p.G964G	LARS_uc003lnw.1_Silent_p.G122G|LARS_uc011dbq.1_Silent_p.G918G|LARS_uc011dbr.1_Silent_p.G910G|LARS_uc011dbs.1_Silent_p.G937G	NM_020117	NP_064502	Q9P2J5	SYLC_HUMAN	leucyl-tRNA synthetase	964					leucyl-tRNA aminoacylation	cytosol	ATP binding|leucine-tRNA ligase activity|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		L-Leucine(DB00149)	CAGGCAGTTTTCCGTTATTGG	0.408		NA											31	9					0	0	0	0
CCNJL	79616	broad.mit.edu	37	5	159686758	159686758	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr5:159686758C>A	uc003lyb.1	-	5	697	c.445G>T	c.(445-447)GAC>TAC	p.D149Y	CCNJL_uc011dee.1_Missense_Mutation_p.D101Y|CCNJL_uc003lyc.1_RNA|CCNJL_uc011def.1_Missense_Mutation_p.D101Y	NM_024565	NP_078841	Q8IV13	CCNJL_HUMAN	cyclin J-like	149	Cyclin N-terminal.					nucleus					0	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GGGACGTGGTCTTCCCGATCC	0.557		NA											29	24					1.89e-17	2.23e-17	1	0
RNF130	55819	broad.mit.edu	37	5	179440200	179440200	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr5:179440200A>T	uc003mll.1	-	3	961	c.554T>A	c.(553-555)ATG>AAG	p.M185K	RNF130_uc003mlm.1_Missense_Mutation_p.M185K	NM_018434	NP_060904	Q86XS8	GOLI_HUMAN	ring finger protein 130 precursor	185	Extracellular (Potential).				apoptosis	cytoplasm|integral to membrane|nucleus	ubiquitin-protein ligase activity|zinc ion binding			lung(2)|ovary(1)	3	all_cancers(89;5.49e-05)|all_epithelial(37;1.94e-05)|Renal(175;0.000159)|Lung NSC(126;0.00118)|all_lung(126;0.00212)	all_cancers(40;0.0294)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CTTCGGTGGCATTCGAGTTCC	0.373		NA											26	74					0	0	0	0
TRIM41	90933	broad.mit.edu	37	5	180651243	180651243	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr5:180651243T>G	uc003mne.1	+	1	938	c.244T>G	c.(244-246)TGG>GGG	p.W82G	uc003mnb.1_3'UTR|TRIM41_uc003mnc.1_Missense_Mutation_p.W82G|TRIM41_uc003mnd.1_Missense_Mutation_p.W82G|TRIM41_uc003mnf.1_RNA	NM_033549	NP_291027	Q8WV44	TRI41_HUMAN	tripartite motif-containing 41 isoform 1	82	Glu-rich.					cytoplasm|nucleus	ligase activity|protein binding|zinc ion binding				0	all_cancers(89;9.17e-06)|all_epithelial(37;1.19e-06)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0684)	all_cancers(40;0.000209)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_lung(500;0.0221)|all_hematologic(541;0.0433)|Lung NSC(249;0.132)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TGGCGCGGGGTGGGACACCCC	0.493		NA											13	57					0	0	0	0
EXOC2	55770	broad.mit.edu	37	6	556005	556005	+	Silent	SNP	T	T	C			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr6:556005T>C	uc003mtd.2	-	19	2075	c.1941A>G	c.(1939-1941)CAA>CAG	p.Q647Q	EXOC2_uc003mte.2_Silent_p.Q647Q|EXOC2_uc011dho.1_Silent_p.Q242Q	NM_018303	NP_060773	Q96KP1	EXOC2_HUMAN	Sec5 protein	647					exocytosis|protein transport					breast(4)|ovary(2)|pancreas(1)	7	Ovarian(93;0.0733)	Breast(5;0.0014)|all_lung(73;0.0697)|all_hematologic(90;0.0897)		OV - Ovarian serous cystadenocarcinoma(45;0.0507)|BRCA - Breast invasive adenocarcinoma(62;0.14)		TTTTAGGTTGTTGGAAGACCT	0.338		NA											34	40					0	0	0	0
SYCP2L	221711	broad.mit.edu	37	6	10907904	10907904	+	Missense_Mutation	SNP	G	G	C	rs143568506	by1000genomes	TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr6:10907904G>C	uc003mzo.2	+	10	1102	c.806G>C	c.(805-807)CGA>CCA	p.R269P	SYCP2L_uc011din.1_Missense_Mutation_p.R110P|SYCP2L_uc010jow.2_5'UTR	NM_001040274	NP_001035364	Q5T4T6	SYC2L_HUMAN	synaptonemal complex protein 2-like	269						nucleus				ovary(1)|skin(1)	2	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)	Epithelial(50;0.239)			ATTAAGGATCGAGAATTTGAG	0.403		NA											35	53					0	0	0	0
BMP5	653	broad.mit.edu	37	6	55620386	55620386	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr6:55620386T>A	uc003pcq.2	-	7	2022	c.1310A>T	c.(1309-1311)AAT>ATT	p.N437I	BMP5_uc011dxf.1_Missense_Mutation_p.N400I	NM_021073	NP_066551	P22003	BMP5_HUMAN	bone morphogenetic protein 5 preproprotein	437					cartilage development|cell differentiation|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			ovary(2)	2	Lung NSC(77;0.0462)		LUSC - Lung squamous cell carcinoma(124;0.181)			CAAAATGACATTGGAGCTGTC	0.353		NA											28	35					0	0	0	0
LAMA4	3910	broad.mit.edu	37	6	112513043	112513043	+	Silent	SNP	G	G	A	rs140249081		TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr6:112513043G>A	uc003pvu.2	-	6	822	c.513C>T	c.(511-513)CCC>CCT	p.P171P	LAMA4_uc003pvv.2_Silent_p.P171P|LAMA4_uc003pvt.2_Silent_p.P171P	NM_001105206	NP_001098676	Q16363	LAMA4_HUMAN	laminin, alpha 4 isoform 1 precursor	171	Laminin EGF-like 2.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		CATAGTAACCGGGAGCACATC	0.358		NA											6	22					0	0	0	0
C6orf174	387104	broad.mit.edu	37	6	127796905	127796905	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr6:127796905C>T	uc003qbd.2	-	6	3131	c.2266G>A	c.(2266-2268)GAC>AAC	p.D756N	C6orf174_uc003qbc.2_5'Flank	NM_001012279	NP_001012279	Q5TF21	CF174_HUMAN	hypothetical protein LOC387104 precursor	756						integral to membrane				breast(3)|ovary(2)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.026)|all cancers(137;0.161)		TTGCCCGCGTCGCTCTCGGCG	0.692		NA											24	53					0	0	0	0
MAP3K5	4217	broad.mit.edu	37	6	136977517	136977517	+	Silent	SNP	T	T	C			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr6:136977517T>C	uc003qhc.2	-	10	1969	c.1608A>G	c.(1606-1608)CAA>CAG	p.Q536Q	MAP3K5_uc011edj.1_5'UTR|MAP3K5_uc011edk.1_Silent_p.Q381Q|MAP3K5_uc010kgw.1_Silent_p.Q536Q	NM_005923	NP_005914	Q99683	M3K5_HUMAN	mitogen-activated protein kinase kinase kinase	536					activation of JUN kinase activity|activation of MAPKK activity|cellular response to hydrogen peroxide|induction of apoptosis by extracellular signals|interspecies interaction between organisms		ATP binding|caspase activator activity|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein phosphatase binding			ovary(2)|skin(2)|lung(1)	5	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00137)|OV - Ovarian serous cystadenocarcinoma(155;0.00569)		CCACAAGTTCTTGCTTGGCCA	0.393		NA											45	94					0	0	0	0
OLIG3	167826	broad.mit.edu	37	6	137814642	137814642	+	Silent	SNP	C	C	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr6:137814642C>T	uc003qhp.1	-	1	890	c.666G>A	c.(664-666)CCG>CCA	p.P222P		NM_175747	NP_786923	Q7RTU3	OLIG3_HUMAN	oligodendrocyte transcription factor 3	222					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0	Breast(32;0.165)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00161)|OV - Ovarian serous cystadenocarcinoma(155;0.00447)		GCAGCGCGGGCGGCGTGGAGG	0.711		NA											3	2					0	0	0	0
FBXO30	84085	broad.mit.edu	37	6	146127529	146127529	+	Silent	SNP	G	G	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr6:146127529G>A	uc003qla.2	-	2	212	c.13C>T	c.(13-15)CTG>TTG	p.L5L	uc003qky.1_Intron	NM_032145	NP_115521	Q8TB52	FBX30_HUMAN	F-box only protein 30	5							ubiquitin-protein ligase activity|zinc ion binding			ovary(2)|large_intestine(1)	3		Ovarian(120;0.0776)		OV - Ovarian serous cystadenocarcinoma(155;1.95e-07)|GBM - Glioblastoma multiforme(68;0.0149)		GAATGCTGCAGCTCCTCCTCC	0.413		NA											10	24					0	0	0	0
PDE10A	10846	broad.mit.edu	37	6	165752811	165752811	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr6:165752811G>A	uc003qun.2	-	21	2345	c.2104C>T	c.(2104-2106)CCT>TCT	p.P702S	PDE10A_uc011egj.1_RNA|PDE10A_uc011egk.1_Missense_Mutation_p.P632S|PDE10A_uc003quo.2_Missense_Mutation_p.P712S	NM_006661	NP_006652	Q9Y233	PDE10_HUMAN	phosphodiesterase 10A isoform 2	702					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			ovary(3)|skin(2)	5		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	TCCATCATAGGAATAGGCTGT	0.353		NA											22	61					0	0	0	0
DLL1	28514	broad.mit.edu	37	6	170592411	170592411	+	Silent	SNP	G	G	A	rs140596420		TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr6:170592411G>A	uc003qxm.2	-	9	2426	c.1956C>T	c.(1954-1956)ACC>ACT	p.T652T		NM_005618	NP_005609	O00548	DLL1_HUMAN	delta-like 1 precursor	652	Cytoplasmic (Potential).				cell communication|cell fate determination|hemopoiesis|Notch receptor processing|Notch signaling pathway|regulation of cell adhesion	extracellular region|integral to plasma membrane	calcium ion binding|Notch binding			lung(4)|ovary(1)	5		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;6.71e-23)|BRCA - Breast invasive adenocarcinoma(81;4.81e-06)|GBM - Glioblastoma multiforme(31;0.0584)		CCCTGACGGCGGTGTCGTCAC	0.662		NA											8	35					0	0	0	0
MIOS	54468	broad.mit.edu	37	7	7628164	7628164	+	Silent	SNP	A	A	G			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr7:7628164A>G	uc003srf.2	+	8	2162	c.1854A>G	c.(1852-1854)GCA>GCG	p.A618A	MIOS_uc003srg.2_Silent_p.A153A|MIOS_uc010ktq.2_Missense_Mutation_p.H16R	NM_019005	NP_061878	Q9NXC5	MIO_HUMAN	missing oocyte, meiosis regulator, homolog	618											0						ACAGAGTGGCATTTGCTTGTA	0.348		NA											27	36					0	0	0	0
AMPH	273	broad.mit.edu	37	7	38530702	38530702	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr7:38530702T>C	uc003tgu.2	-	5	413	c.344A>G	c.(343-345)GAT>GGT	p.D115G	AMPH_uc003tgv.2_Missense_Mutation_p.D115G	NM_001635	NP_001626	P49418	AMPH_HUMAN	amphiphysin isoform 1	115	BAR.				endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				ovary(3)|liver(1)|skin(1)	5						CAAGGACCCATCCACGAGTTT	0.398		NA											42	174					0	0	0	0
ZNF479	90827	broad.mit.edu	37	7	57188062	57188062	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr7:57188062C>T	uc010kzo.2	-	5	1331	c.1060G>A	c.(1060-1062)GCC>ACC	p.A354T		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	zinc finger protein 479	354	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(1;9.18e-12)			TCTTCACAGGCATAGGGTTTC	0.443		NA											4	11					0	0	0	0
SRCRB4D	136853	broad.mit.edu	37	7	76021316	76021316	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr7:76021316T>A	uc003ufb.2	-	10	1724	c.1376A>T	c.(1375-1377)GAG>GTG	p.E459V	SRCRB4D_uc003ufa.2_5'UTR	NM_080744	NP_542782	Q8WTU2	SRB4D_HUMAN	scavenger receptor cysteine rich domain	459						extracellular region|membrane	scavenger receptor activity			pancreas(1)	1						CCGCGTGGTCTCAGAACCATC	0.592		NA											5	10					0	0	0	0
PON1	5444	broad.mit.edu	37	7	94931578	94931578	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr7:94931578C>G	uc003uns.2	-	8	945	c.848G>C	c.(847-849)GGA>GCA	p.G283A	PON1_uc011kih.1_Missense_Mutation_p.G283A	NM_000446	NP_000437	P27169	PON1_HUMAN	paraoxonase 1 precursor	283					aromatic compound catabolic process|carboxylic acid catabolic process|organophosphate catabolic process|phosphatidylcholine metabolic process|positive regulation of binding|positive regulation of cholesterol efflux|positive regulation of transporter activity|response to external stimulus	spherical high-density lipoprotein particle	aryldialkylphosphatase activity|arylesterase activity|calcium ion binding|phospholipid binding|protein homodimerization activity			pancreas(1)	1	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0031)		Atorvastatin(DB01076)|Cefazolin(DB01327)	GGGATGGCATCCAACCCAAAG	0.388		NA											13	65					0	0	0	0
ARPC1A	10552	broad.mit.edu	37	7	98931012	98931012	+	Silent	SNP	C	C	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr7:98931012C>T	uc003upx.1	+	2	183	c.36C>T	c.(34-36)ACC>ACT	p.T12T	ARPC1A_uc010lfu.1_RNA|ARPC1A_uc003upy.1_5'UTR|ARPC1A_uc011kit.1_RNA	NM_006409	NP_006400	Q92747	ARC1A_HUMAN	actin related protein 2/3 complex subunit 1A	12	WD 1.				actin cytoskeleton organization|regulation of actin filament polymerization	actin cytoskeleton|cytoplasm	actin binding			ovary(1)	1	all_cancers(62;4.46e-09)|all_epithelial(64;3.44e-10)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0258)		STAD - Stomach adenocarcinoma(171;0.215)			AGCCAATCACCTGTCATGCCT	0.343		NA											14	32					0	0	0	0
CTTNBP2	83992	broad.mit.edu	37	7	117351772	117351772	+	Nonsense_Mutation	SNP	A	A	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr7:117351772A>T	uc003vjf.2	-	23	4903	c.4811T>A	c.(4810-4812)TTG>TAG	p.L1604*		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	1604										ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		TGAAACACCCAACTCAGTCTT	0.423		NA											60	54					0	0	0	0
CADPS2	93664	broad.mit.edu	37	7	122091450	122091450	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr7:122091450C>G	uc010lkp.2	-	14	2429	c.2266G>C	c.(2266-2268)GAA>CAA	p.E756Q	CADPS2_uc011knx.1_Missense_Mutation_p.E127Q|CADPS2_uc003vkg.3_Missense_Mutation_p.E453Q|CADPS2_uc010lkq.2_Missense_Mutation_p.E753Q	NM_017954	NP_060424	Q86UW7	CAPS2_HUMAN	Ca2+-dependent activator protein for secretion 2	756	Interaction with DRD2.				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding			ovary(1)|central_nervous_system(1)	2						ATCTGATTTTCTAAAAGGGAA	0.299		NA											5	30					0	0	0	0
TRIM24	8805	broad.mit.edu	37	7	138252382	138252382	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr7:138252382C>A	uc003vuc.2	+	10	1902	c.1687C>A	c.(1687-1689)CAA>AAA	p.Q563K	TRIM24_uc003vub.2_Missense_Mutation_p.Q529K	NM_015905	NP_056989	O15164	TIF1A_HUMAN	transcriptional intermediary factor 1 alpha	563					cellular response to estrogen stimulus|protein catabolic process|regulation of apoptosis|regulation of protein stability|transcription from RNA polymerase II promoter	cytoplasm	chromatin binding|estrogen response element binding|histone acetyl-lysine binding|p53 binding|transcription coactivator activity|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(3)|ovary(2)|stomach(1)|breast(1)|skin(1)	8						TTTCTTGGCTCAACAAGCCAT	0.388		NA											10	44					5.62e-17	6.64e-17	1	0
SSPO	23145	broad.mit.edu	37	7	149474828	149474828	+	Silent	SNP	C	C	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr7:149474828C>T	uc010lpk.2	+	5	627	c.627C>T	c.(625-627)CGC>CGT	p.R209R	SSPO_uc010lpl.1_Intron	NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	209	VWFD 1.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			TTGATGGCCGCCACTATCACT	0.697		NA											12	13					0	0	0	0
RP1	6101	broad.mit.edu	37	8	55541985	55541985	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr8:55541985C>A	uc003xsd.1	+	4	5691	c.5543C>A	c.(5542-5544)GCA>GAA	p.A1848E	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	1848					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			GAAAGAATAGCAAATCATCAT	0.413		NA											11	78					2.81e-09	3.18e-09	1	0
CYP7A1	1581	broad.mit.edu	37	8	59410989	59410989	+	Silent	SNP	T	T	C			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr8:59410989T>C	uc003xtm.3	-	2	183	c.120A>G	c.(118-120)CCA>CCG	p.P40P		NM_000780	NP_000771	P22680	CP7A1_HUMAN	cytochrome P450, family 7, subfamily A,	40					bile acid biosynthetic process|cellular lipid metabolic process|cellular response to cholesterol|cellular response to glucose stimulus|cholesterol catabolic process|cholesterol homeostasis|regulation of bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholesterol 7-alpha-monooxygenase activity|electron carrier activity|heme binding			ovary(1)	1		all_lung(136;0.0271)|Lung NSC(129;0.0351)|all_epithelial(80;0.0554)				AGCCCAGGTATGGAATTAATC	0.418		NA							Neonatal_Giant_Cell_Hepatitis				72	210					0	0	0	0
SLCO5A1	81796	broad.mit.edu	37	8	70744483	70744483	+	Silent	SNP	C	C	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr8:70744483C>T	uc003xyl.2	-	2	1133	c.426G>A	c.(424-426)GCG>GCA	p.A142A	SLCO5A1_uc010lzb.2_Silent_p.A142A|SLCO5A1_uc011lfa.1_RNA|SLCO5A1_uc003xyk.2_Silent_p.A142A|SLCO5A1_uc010lzc.2_Silent_p.A142A	NM_030958	NP_112220	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family,	142	Helical; Name=1; (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|upper_aerodigestive_tract(1)	4	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			AGACCATTAACGCCTGGATGA	0.557		NA									OREG0018815	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	52					0	0	0	0
ATP6V0D2	245972	broad.mit.edu	37	8	87163762	87163762	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr8:87163762A>G	uc003ydp.1	+	7	953	c.884A>G	c.(883-885)GAG>GGG	p.E295G		NM_152565	NP_689778	Q8N8Y2	VA0D2_HUMAN	ATPase, H+ transporting, lysosomal 38kDa, V0	295					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	apical plasma membrane|endosome membrane|proton-transporting V-type ATPase, V0 domain|vacuolar proton-transporting V-type ATPase complex	hydrogen ion transmembrane transporter activity|protein binding				0						GTGTTTTACGAGCGTGAGGTA	0.328		NA											15	51					0	0	0	0
VPS13B	157680	broad.mit.edu	37	8	100789144	100789144	+	Silent	SNP	G	G	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr8:100789144G>A	uc003yiv.2	+	41	7575	c.7464G>A	c.(7462-7464)CTG>CTA	p.L2488L	VPS13B_uc003yiw.2_Silent_p.L2463L	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	2488					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TTGCTCACCTGGAATTCCATC	0.438		NA											84	226					0	0	0	0
KCNV1	27012	broad.mit.edu	37	8	110984585	110984585	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr8:110984585C>A	uc003ynr.3	-	2	1235	c.893G>T	c.(892-894)AGC>ATC	p.S298I	KCNV1_uc010mcw.2_Missense_Mutation_p.S298I	NM_014379	NP_055194	Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	298	Extracellular (Potential).					voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			lung(1)|kidney(1)	2	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			CGTGGTCTGGCTCCCACTTAG	0.562		NA											14	48					2.32e-09	2.64e-09	1	0
GSDMC	56169	broad.mit.edu	37	8	130765053	130765053	+	Silent	SNP	G	G	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr8:130765053G>A	uc003ysr.2	-	7	1617	c.735C>T	c.(733-735)TCC>TCT	p.S245S		NM_031415	NP_113603	Q9BYG8	GSDMC_HUMAN	melanoma-derived leucine zipper, extra-nuclear	245						mitochondrion				ovary(2)|skin(1)	3						ctaccatttcggaaatttcgt	0		NA											13	86					0	0	0	0
TG	7038	broad.mit.edu	37	8	133881999	133881999	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr8:133881999C>A	uc003ytw.2	+	3	243	c.202C>A	c.(202-204)CGC>AGC	p.R68S		NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	68	Thyroglobulin type-1 1.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GAACGACGGCCGCTCCTGCTG	0.652		NA											61	40					1.41e-22	1.7e-22	1	0
ZFAT	57623	broad.mit.edu	37	8	135524795	135524795	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr8:135524795G>A	uc003yup.2	-	14	3459	c.3284C>T	c.(3283-3285)ACA>ATA	p.T1095I	ZFAT_uc011ljj.1_Missense_Mutation_p.T214I|ZFAT_uc003yun.2_Missense_Mutation_p.T1083I|ZFAT_uc003yuo.2_Missense_Mutation_p.T1083I|ZFAT_uc010meh.2_Intron|ZFAT_uc010mei.2_RNA|ZFAT_uc003yuq.2_Missense_Mutation_p.T1083I|ZFAT_uc010mej.2_Missense_Mutation_p.T1033I	NM_020863	NP_065914	Q9P243	ZFAT_HUMAN	zinc finger protein 406 isoform ZFAT-1	1095					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)			TTCGGCCTCTGTGATGTGGAG	0.522		NA											34	229					0	0	0	0
TRPM3	80036	broad.mit.edu	37	9	73399062	73399062	+	Silent	SNP	C	C	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr9:73399062C>T	uc004aid.2	-	7	1351	c.1107G>A	c.(1105-1107)TCG>TCA	p.S369S	TRPM3_uc004ahu.2_Silent_p.S199S|TRPM3_uc004ahv.2_Silent_p.S199S|TRPM3_uc004ahw.2_Silent_p.S241S|TRPM3_uc004ahx.2_Silent_p.S216S|TRPM3_uc004ahy.2_Silent_p.S241S|TRPM3_uc004ahz.2_Silent_p.S216S|TRPM3_uc004aia.2_Silent_p.S216S|TRPM3_uc004aib.2_Silent_p.S216S|TRPM3_uc004aic.2_Silent_p.S369S|TRPM3_uc010mor.2_Silent_p.S369S|TRPM3_uc004aie.2_Silent_p.S216S|TRPM3_uc004aif.2_Silent_p.S241S|TRPM3_uc004aig.2_Silent_p.S216S	NM_001007471	NP_001007472	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel,	394	Cytoplasmic (Potential).					integral to membrane	calcium channel activity			ovary(3)|pancreas(2)|central_nervous_system(2)|skin(2)	9						CCAGGATGTCCGATGCCCGTC	0.527		NA											33	19					0	0	0	0
PRUNE2	158471	broad.mit.edu	37	9	79323433	79323433	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr9:79323433G>T	uc010mpk.2	-	8	3881	c.3757C>A	c.(3757-3759)CCC>ACC	p.P1253T		NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	1253					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						GAATGGCTGGGGATTTCAGGA	0.453		NA											22	11					2.22e-12	2.58e-12	1	0
COL15A1	1306	broad.mit.edu	37	9	101816858	101816858	+	Missense_Mutation	SNP	G	G	T	rs140851301	by1000genomes	TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr9:101816858G>T	uc004azb.1	+	32	3157	c.2951G>T	c.(2950-2952)GGT>GTT	p.G984V		NM_001855	NP_001846	P39059	COFA1_HUMAN	alpha 1 type XV collagen precursor	984	Triple-helical region 6 (COL6).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			ovary(6)	6		Acute lymphoblastic leukemia(62;0.0562)				TTGGTGGCAGGTGTTAAAGGA	0.433		NA											21	8					3.62e-10	4.16e-10	1	0
OR13F1	138805	broad.mit.edu	37	9	107267404	107267404	+	Silent	SNP	T	T	C			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr9:107267404T>C	uc011lvm.1	+	1	861	c.861T>C	c.(859-861)CCT>CCC	p.P287P		NM_001004485	NP_001004485	Q8NGS4	O13F1_HUMAN	olfactory receptor, family 13, subfamily F,	287	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)|skin(1)	3						TGTTGAATCCTATCATCTATA	0.418		NA											41	6					0	0	0	0
C9orf43	257169	broad.mit.edu	37	9	116191548	116191548	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr9:116191548C>T	uc004bho.3	+	14	1664	c.1268C>T	c.(1267-1269)TCC>TTC	p.S423F	C9orf43_uc004bhp.2_Missense_Mutation_p.S423F	NM_152786	NP_689999	Q8TAL5	CI043_HUMAN	hypothetical protein LOC257169	423											0						AAGAAGATCTCCTTTAACTTT	0.468		NA											19	67					0	0	0	0
ZER1	10444	broad.mit.edu	37	9	131515598	131515598	+	Silent	SNP	C	C	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr9:131515598C>T	uc004bwa.1	-	4	1024	c.591G>A	c.(589-591)CCG>CCA	p.P197P		NM_006336	NP_006327	Q7Z7L7	ZER1_HUMAN	zyg-11 homolog B (C. elegans)-like	197					ATP hydrolysis coupled proton transport|regulation of ubiquitin-protein ligase activity	Cul2-RING ubiquitin ligase complex|vacuolar proton-transporting V-type ATPase, V1 domain	protein binding|proton-transporting ATPase activity, rotational mechanism|ubiquitin-protein ligase activity			ovary(1)	1						GGGAGTTAAGCGGCCGCAGCA	0.602		NA											8	5					0	0	0	0
RS1	6247	broad.mit.edu	37	X	18660166	18660166	+	Silent	SNP	G	G	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chrX:18660166G>A	uc004cyo.2	-	6	668	c.633C>T	c.(631-633)GCC>GCT	p.A211A	CDKL5_uc004cym.2_Intron|CDKL5_uc004cyn.2_Intron	NM_000330	NP_000321	O15537	XLRS1_HUMAN	X-linked juvenile retinoschisis protein	211	F5/8 type C.				cell adhesion|multicellular organismal development|response to stimulus|visual perception	extracellular space				ovary(2)	2	Hepatocellular(33;0.183)					CCATCCGGATGGCAATGCGGA	0.677		NA											34	10					0	0	0	0
MTMR8	55613	broad.mit.edu	37	X	63445187	63445187	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chrX:63445187C>G	uc011mou.1	-	10	1537	c.1469G>C	c.(1468-1470)AGT>ACT	p.S490T	ASB12_uc004dvp.1_Missense_Mutation_p.S106T|ASB12_uc004dvq.1_Missense_Mutation_p.S115T|ASB12_uc004dvr.1_Missense_Mutation_p.S115T	NM_017677	NP_060147	Q96EF0	MTMR8_HUMAN	myotubularin related protein 8	306	Myotubularin phosphatase.					nuclear envelope	protein tyrosine phosphatase activity			ovary(2)|breast(2)	4						ATGGCCATGACTGACAGCAGT	0.527		NA											7	5					0	0	0	0
PHKA1	5255	broad.mit.edu	37	X	71887231	71887231	+	Silent	SNP	G	G	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chrX:71887231G>A	uc004eax.3	-	7	1012	c.711C>T	c.(709-711)CAC>CAT	p.H237H	PHKA1_uc004eay.3_Silent_p.H237H|PHKA1_uc011mqi.1_Silent_p.H237H	NM_002637	NP_002628	P46020	KPB1_HUMAN	phosphorylase kinase, alpha 1 (muscle) isoform	237					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			ovary(3)|skin(1)	4	Renal(35;0.156)					TTACCTGGCAGTGCTGTACTT	0.423		NA											18	7					0	0	0	0
IL1RAPL2	26280	broad.mit.edu	37	X	104512216	104512216	+	Missense_Mutation	SNP	A	A	C			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chrX:104512216A>C	uc004elz.1	+	5	1445	c.689A>C	c.(688-690)AAA>ACA	p.K230T		NM_017416	NP_059112	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	230	Ig-like C2-type 2.|Extracellular (Potential).				central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(2)|ovary(1)	3						ACTGAATTGAAAGTTACAGGT	0.333		NA											25	10					0	0	0	0
COL4A6	1288	broad.mit.edu	37	X	107553986	107553986	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chrX:107553986C>T	uc004enw.3	-	3	242	c.139G>A	c.(139-141)GGA>AGA	p.G47R	COL4A6_uc004env.3_Missense_Mutation_p.G46R|COL4A6_uc011msn.1_Missense_Mutation_p.G46R|COL4A6_uc010npk.2_Missense_Mutation_p.G46R|COL4A6_uc004enx.2_RNA|COL4A6_uc004eny.2_RNA	NM_001847	NP_001838	Q14031	CO4A6_HUMAN	type IV alpha 6 collagen isoform A precursor	47	Triple-helical region.				cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(6)|urinary_tract(1)|large_intestine(1)	8						ACTCTCGCTCCTTTCTCAGGA	0.383		NA							Alport_syndrome_with_Diffuse_Leiomyomatosis				41	7					0	0	0	0
MAST2	23139	broad.mit.edu	37	1	46295227	46295228	+	Frame_Shift_Del	DEL	TC	TC	-			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr1:46295227_46295228delTC	uc001cov.2	+	3	725_726	c.442_443delTC	c.(442-444)TCTfs	p.S148fs	MAST2_uc001cow.2_Frame_Shift_Del_p.S148fs	NM_015112	NP_055927	Q6P0Q8	MAST2_HUMAN	microtubule associated serine/threonine kinase	148					regulation of interleukin-12 biosynthetic process|spermatid differentiation	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|phosphatase binding|protein serine/threonine kinase activity			ovary(5)|lung(3)|stomach(2)|breast(1)	11	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.184)					CCTTGGACAGTCTGCACCTTCT	0.446		NA											39	32	---	---	---	---	NA	NA	NA	NA
KIAA0907	22889	broad.mit.edu	37	1	155887376	155887387	+	In_Frame_Del	DEL	GGGGCTGGGGCT	GGGGCTGGGGCT	-			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr1:155887376_155887387delGGGGCTGGGGCT	uc001fmi.1	-	11	1367_1378	c.1343_1354delAGCCCCAGCCCC	c.(1342-1356)CAGCCCCAGCCCCCA>CCA	p.QPQP448del	KIAA0907_uc001fmj.1_In_Frame_Del_p.QPQP448del|KIAA0907_uc009wrk.1_In_Frame_Del_p.QPQP305del|KIAA0907_uc009wrl.1_RNA	NM_014949	NP_055764	Q7Z7F0	K0907_HUMAN	hypothetical protein LOC22889	448_451	Pro-rich.										0	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;8.82e-06)			CTTGGGAGTGggggctggggctggggctgggg	0.439		NA											14	75	---	---	---	---	NA	NA	NA	NA
CDH1	999	broad.mit.edu	37	16	68847250	68847255	+	In_Frame_Del	DEL	TCGTAA	TCGTAA	-	rs148080550		TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr16:68847250_68847255delTCGTAA	uc002ewg.1	+	9	1296_1301	c.1172_1177delTCGTAA	c.(1171-1179)GTCGTAATC>GTC	p.VI392del	CDH1_uc010vlj.1_RNA|CDH1_uc010cfg.1_Intron	NM_004360	NP_004351	P12830	CADH1_HUMAN	cadherin 1, type 1 preproprotein	392_393	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cellular component disassembly involved in apoptosis|cellular response to indole-3-methanol|cellular response to lithium ion|homophilic cell adhesion|negative regulation of cell-cell adhesion|positive regulation of transcription factor import into nucleus|positive regulation of transcription, DNA-dependent|regulation of immune response	actin cytoskeleton|aggresome|apical junction complex|catenin complex|cell-cell adherens junction|endosome|focal adhesion|Golgi apparatus|integral to membrane|internal side of plasma membrane|lateral plasma membrane|perinuclear region of cytoplasm	cell adhesion molecule binding|gamma-catenin binding	p.Y380_K440del(5)		breast(148)|stomach(71)|biliary_tract(8)|endometrium(3)|soft_tissue(2)|large_intestine(2)|urinary_tract(2)|oesophagus(2)|ovary(2)|thyroid(1)|central_nervous_system(1)|lung(1)	243		all_neural(199;0.0189)|Ovarian(137;0.0563)		Epithelial(162;8.44e-05)|all cancers(182;0.000404)|OV - Ovarian serous cystadenocarcinoma(108;0.000426)|BRCA - Breast invasive adenocarcinoma(181;0.0261)		GAGGCTAACGTCGTAATCACCACACT	0.495		NA	Mis|N|F|S		lobular breast|gastric	gastric			Hereditary_Diffuse_Gastric_Cancer				16	64	---	---	---	---	NA	NA	NA	NA
CHD3	1107	broad.mit.edu	37	17	7797825	7797826	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr17:7797825_7797826insA	uc002gje.2	+	8	1318_1319	c.1168_1169insA	c.(1168-1170)GAAfs	p.E390fs	CHD3_uc002gjd.2_Frame_Shift_Ins_p.E449fs|CHD3_uc002gjf.2_Frame_Shift_Ins_p.E390fs|CHD3_uc002gjg.1_Frame_Shift_Ins_p.E218fs	NM_001005273	NP_001005273	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	390	PHD-type 1.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(1)	1		Prostate(122;0.202)				GCAGGGTGGGGAAATTATTCTG	0.589		NA											30	60	---	---	---	---	NA	NA	NA	NA
TMEM200C	645369	broad.mit.edu	37	18	5890315	5890324	+	Frame_Shift_Del	DEL	GGTGGCTCCT	GGTGGCTCCT	-			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr18:5890315_5890324delGGTGGCTCCT	uc002kmx.1	-	1	1780_1789	c.1739_1748delAGGAGCCACC	c.(1738-1749)CAGGAGCCACCCfs	p.Q580fs		NM_001080209	NP_001073678	A6NKL6	T200C_HUMAN	transmembrane protein 200C	580_583						integral to membrane					0						CTCGGCCGTGGGTGGCTCCTGGCTGGCACC	0.6		NA											8	85	---	---	---	---	NA	NA	NA	NA
NOTCH3	4854	broad.mit.edu	37	19	15296203	15296204	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr19:15296203_15296204delCA	uc002nan.2	-	14	2236_2237	c.2160_2161delTG	c.(2158-2163)TGTGAGfs	p.C720fs	NOTCH3_uc002nao.1_Frame_Shift_Del_p.C720fs	NM_000435	NP_000426	Q9UM47	NOTC3_HUMAN	Notch homolog 3 precursor	720_721	Extracellular (Potential).|EGF-like 18.				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			lung(8)|ovary(5)|skin(4)|prostate(2)|central_nervous_system(1)|breast(1)	21			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			CAGCCAGGCTCACACACACAGC	0.688		NA											11	14	---	---	---	---	NA	NA	NA	NA
FAT1	2195	broad.mit.edu	37	4	187532702	187532705	+	Frame_Shift_Del	DEL	CAAA	CAAA	-			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chr4:187532702_187532705delCAAA	uc003izf.2	-	14	9876_9879	c.9688_9691delTTTG	c.(9688-9693)TTTGAGfs	p.F3230fs		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	3230_3231	Extracellular (Potential).|Cadherin 30.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						TCACGGTACTCAAACACAGGGGGG	0.471		NA								HNSCC(5;0.00058)			22	15	---	---	---	---	NA	NA	NA	NA
DMD	1756	broad.mit.edu	37	X	31227736	31227736	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CN-6024-01A-11D-1683-08	TCGA-CN-6024-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0604584e-0654-4b00-94fc-45e76588000c	f6a9ac40-b1a9-4915-bfda-f2d01607b2b4	g.chrX:31227736delG	uc004dda.1	-	65	9686	c.9442delC	c.(9442-9444)CTGfs	p.L3148fs	DMD_uc004dcq.1_Frame_Shift_Del_p.L419fs|DMD_uc004dcr.1_Frame_Shift_Del_p.L688fs|DMD_uc004dcs.1_Frame_Shift_Del_p.L688fs|DMD_uc004dct.1_Frame_Shift_Del_p.L688fs|DMD_uc004dcu.1_Frame_Shift_Del_p.L688fs|DMD_uc004dcv.1_Frame_Shift_Del_p.L688fs|DMD_uc004dcw.2_Frame_Shift_Del_p.L1804fs|DMD_uc004dcx.2_Frame_Shift_Del_p.L1807fs|DMD_uc004dcz.2_Frame_Shift_Del_p.L3025fs|DMD_uc004dcy.1_Frame_Shift_Del_p.L3144fs|DMD_uc004ddb.1_Frame_Shift_Del_p.L3140fs|DMD_uc004dcm.1_Frame_Shift_Del_p.L80fs|DMD_uc004dcn.1_Frame_Shift_Del_p.L80fs|DMD_uc004dco.1_Frame_Shift_Del_p.L80fs|DMD_uc004dcp.1_Frame_Shift_Del_p.L80fs|DMD_uc011mkb.1_Frame_Shift_Del_p.L80fs|DMD_uc010ngm.2_Frame_Shift_Del_p.L80fs	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	3148	Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				ATAATCTGCAGGATATCCATG	0.448		NA											21	11	---	---	---	---	NA	NA	NA	NA