Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
AGRN	375790	broad.mit.edu	37	1	982024	982024	+	Silent	SNP	G	G	A			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr1:982024G>A	uc001ack.1	+	18	3209	c.3159G>A	c.(3157-3159)GTG>GTA	p.V1053V		NM_198576	NP_940978	O00468	AGRIN_HUMAN	agrin precursor	1053	Ser/Thr-rich.				axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			central_nervous_system(2)|breast(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		CCAGCCTGGTGGCGTCCGCCT	0.687		NA											11	10					0	0	0	0
NMNAT1	64802	broad.mit.edu	37	1	10042404	10042404	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr1:10042404C>T	uc001aqp.2	+	5	629	c.485C>T	c.(484-486)TCC>TTC	p.S162F		NM_022787	NP_073624	Q9HAN9	NMNA1_HUMAN	nicotinamide mononucleotide adenylyltransferase	162					water-soluble vitamin metabolic process	nucleoplasm	ATP binding|nicotinamide-nucleotide adenylyltransferase activity|nicotinate-nucleotide adenylyltransferase activity|protein binding				0		all_lung(284;0.000407)|Renal(390;0.000469)|Lung NSC(185;0.000577)|Colorectal(325;0.0062)|Breast(348;0.00686)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.31e-08)|COAD - Colon adenocarcinoma(227;1.54e-05)|Kidney(185;0.00028)|BRCA - Breast invasive adenocarcinoma(304;0.00032)|KIRC - Kidney renal clear cell carcinoma(229;0.00101)|STAD - Stomach adenocarcinoma(132;0.00908)|READ - Rectum adenocarcinoma(331;0.0419)		TTATTGGAGTCCTTTGCTGTT	0.478		NA											24	87					0	0	0	0
ZMYM6	9204	broad.mit.edu	37	1	35476586	35476586	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr1:35476586G>A	uc001byh.2	-	9	1342	c.1114C>T	c.(1114-1116)CAG>TAG	p.Q372*	ZMYM6_uc001byf.1_Nonsense_Mutation_p.Q372*|ZMYM6_uc010oht.1_Nonsense_Mutation_p.Q275*|ZMYM6_uc009vup.2_Nonsense_Mutation_p.Q178*|ZMYM6_uc009vuq.1_Nonsense_Mutation_p.Q372*|ZMYM6_uc009vur.1_Nonsense_Mutation_p.Q178*	NM_007167	NP_009098	O95789	ZMYM6_HUMAN	zinc finger protein 258	372	MYM-type 5.				multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.13)				ACTTGGCCCTGAGACAGGGGC	0.488		NA											12	48					0	0	0	0
MYSM1	114803	broad.mit.edu	37	1	59147830	59147830	+	Silent	SNP	G	G	A			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr1:59147830G>A	uc009wab.1	-	8	909	c.886C>T	c.(886-888)CTG>TTG	p.L296L	MYSM1_uc001czc.2_RNA	NM_001085487	NP_001078956	Q5VVJ2	MYSM1_HUMAN	Myb-like, SWIRM and MPN domains 1	296					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin remodeling complex	DNA binding|histone binding|metal ion binding|metallopeptidase activity|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(1)	1	all_cancers(7;9.36e-06)					TCAGTCCACAGTGTAATTTCT	0.363		NA											13	109					0	0	0	0
NBPF10	100132406	broad.mit.edu	37	1	145293516	145293516	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr1:145293516C>A	uc001end.3	+	1	146	c.111C>A	c.(109-111)AAC>AAA	p.N37K	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_Missense_Mutation_p.N37K|NOTCH2NL_uc010oyh.1_RNA|NBPF10_uc001emq.1_Missense_Mutation_p.N37K	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	37											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		AGTTCAGAAACCTCAAAGAGA	0.478		NA											6	480					1.59e-06	1.74e-06	1	0
NBPF10	100132406	broad.mit.edu	37	1	145299875	145299875	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr1:145299875C>A	uc001end.3	+	6	959	c.924C>A	c.(922-924)AAC>AAA	p.N308K	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_Missense_Mutation_p.N308K|NBPF10_uc010oyi.1_5'Flank|NBPF10_uc001emq.1_Intron	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	308											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		AGTTCAGAAACCTCAAAGAGA	0.458		NA											37	369					6.43e-24	7.81e-24	1	0
ADIPOR1	51094	broad.mit.edu	37	1	202915728	202915728	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr1:202915728C>T	uc001gyq.3	-	4	536	c.269G>A	c.(268-270)GGA>GAA	p.G90E	ADIPOR1_uc010pqd.1_Missense_Mutation_p.G14E|ADIPOR1_uc001gyr.3_5'UTR|ADIPOR1_uc001gys.3_Missense_Mutation_p.G90E	NM_015999	NP_057083	Q96A54	ADR1_HUMAN	adiponectin receptor 1	90	Cytoplasmic (Potential).				fatty acid oxidation|hormone-mediated signaling pathway	integral to membrane|plasma membrane	hormone binding|protein kinase binding|receptor activity				0			BRCA - Breast invasive adenocarcinoma(75;0.141)			CCTCCAACGTCCCTCCCAGAC	0.502		NA											9	44					0	0	0	0
OBSCN	84033	broad.mit.edu	37	1	228557643	228557643	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr1:228557643C>G	uc009xez.1	+	91	20012	c.19968C>G	c.(19966-19968)AGC>AGG	p.S6656R	OBSCN_uc001hsr.1_Missense_Mutation_p.S1285R	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	6656	Protein kinase 1.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				CTGTCTTCAGCCTGACCTGCT	0.622		NA											45	36					0	0	0	0
BMI1	648	broad.mit.edu	37	10	22618334	22618334	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr10:22618334C>A	uc001irh.2	+	10	1483	c.844C>A	c.(844-846)CCT>ACT	p.P282T	BMI1_uc009xkg.2_Missense_Mutation_p.P425T	NM_005180	NP_005171	P35226	BMI1_HUMAN	BMI1 polycomb ring finger oncogene	282	Pro/Ser-rich.				hemopoiesis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of fibroblast proliferation|positive regulation of ubiquitin-protein ligase activity|segment specification|transcription, DNA-dependent	cytoplasm|nucleolus|PcG protein complex|ubiquitin ligase complex	RING-like zinc finger domain binding|zinc ion binding			ovary(1)|skin(1)	2						AGTGCAGTCTCCTCATCCACA	0.507		NA											25	79					2.45e-14	2.92e-14	1	0
ANKRD26	22852	broad.mit.edu	37	10	27326225	27326225	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr10:27326225T>A	uc001ith.2	-	23	2756	c.2584A>T	c.(2584-2586)AGG>TGG	p.R862W	ANKRD26_uc001itg.2_Missense_Mutation_p.R549W|ANKRD26_uc009xku.1_Missense_Mutation_p.R863W	NM_014915	NP_055730	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	862	Potential.					centrosome				large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|skin(1)	4						GAAAGTTGCCTCTGAGCGTCA	0.358		NA											42	121					0	0	0	0
PTCHD3	374308	broad.mit.edu	37	10	27702586	27702586	+	Silent	SNP	G	G	A			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr10:27702586G>A	uc001itu.2	-	1	712	c.594C>T	c.(592-594)TCC>TCT	p.S198S		NM_001034842	NP_001030014	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	198					spermatid development	integral to membrane	hedgehog receptor activity			ovary(2)|pancreas(1)|skin(1)	4						TCCTGGAGGCGGAGAAGCGGT	0.602		NA											4	131					0	0	0	0
MYOF	26509	broad.mit.edu	37	10	95069804	95069804	+	Silent	SNP	G	G	A			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr10:95069804G>A	uc001kin.2	-	53	6243	c.6120C>T	c.(6118-6120)TTC>TTT	p.F2040F	MYOF_uc001kio.2_Silent_p.F2027F|MYOF_uc009xue.2_RNA	NM_013451	NP_038479	Q9NZM1	MYOF_HUMAN	myoferlin isoform a	2040	Helical; (Potential).				blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			ovary(3)|breast(1)	4						GCACGGCCACGAAGAGCAGCA	0.552		NA											5	30					0	0	0	0
GSTO1	9446	broad.mit.edu	37	10	106027062	106027062	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr10:106027062G>A	uc001kya.2	+	6	634	c.625G>A	c.(625-627)GAT>AAT	p.D209N	GSTO2_uc001kyb.2_5'Flank	NM_004832	NP_004823	P78417	GSTO1_HUMAN	glutathione-S-transferase omega 1	209	GST C-terminal.				xenobiotic metabolic process	cytosol	glutathione transferase activity|monodehydroascorbate reductase (NADH) activity				0		Colorectal(252;0.102)|Breast(234;0.122)		Epithelial(162;8.07e-10)|all cancers(201;2.72e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0147)	Glutathione(DB00143)	CATGAAGGAAGATCCCACAGT	0.493		NA											15	30					0	0	0	0
SHOC2	8036	broad.mit.edu	37	10	112724421	112724421	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr10:112724421C>G	uc001kzl.3	+	2	654	c.305C>G	c.(304-306)TCA>TGA	p.S102*	SHOC2_uc009xxx.2_Nonsense_Mutation_p.S102*|SHOC2_uc010qrg.1_Intron|SHOC2_uc001kzn.2_Nonsense_Mutation_p.S102*	NM_007373	NP_031399	Q9UQ13	SHOC2_HUMAN	soc-2 suppressor of clear homolog	102	LRR 1.				fibroblast growth factor receptor signaling pathway|positive regulation of Ras protein signal transduction|Ras protein signal transduction	nucleus|protein phosphatase type 1 complex	protein phosphatase binding|protein phosphatase regulator activity			ovary(1)|skin(1)	2				Epithelial(162;0.000796)|all cancers(201;0.011)|BRCA - Breast invasive adenocarcinoma(275;0.126)		GAAGAGAATTCAATGCGTTTG	0.383		NA											16	63					0	0	0	0
TRIM68	55128	broad.mit.edu	37	11	4626315	4626315	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr11:4626315C>G	uc001lzf.1	-	2	658	c.420G>C	c.(418-420)GAG>GAC	p.E140D	TRIM68_uc001lzg.1_5'UTR|TRIM68_uc010qyj.1_Intron|TRIM68_uc009yek.1_Missense_Mutation_p.E140D	NM_018073	NP_060543	Q6AZZ1	TRI68_HUMAN	ring finger protein 137	140					protein autoubiquitination|regulation of androgen receptor signaling pathway	Golgi apparatus|nucleolus|perinuclear region of cytoplasm	androgen receptor binding|histone acetyltransferase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;9.49e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0288)|LUSC - Lung squamous cell carcinoma(625;0.192)		TCACCTTGTACTCCCAGGCAA	0.547		NA											5	29					0	0	0	0
KLRC4	8302	broad.mit.edu	37	12	10560266	10560266	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr12:10560266T>C	uc001qye.2	-	4	645	c.463A>G	c.(463-465)ATC>GTC	p.I155V	KLRK1_uc001qyc.2_5'UTR|KLRK1_uc009zhk.2_5'UTR|KLRK1_uc001qyd.2_5'UTR	NM_013431	NP_038459	O43908	NKG2F_HUMAN	killer cell lectin-like receptor subfamily C,	155	Extracellular (Potential).				cellular defense response	integral to membrane	binding|receptor activity				0						AGAAAGCAGATCAGAGTTCTT	0.299		NA											56	109					0	0	0	0
MLL2	8085	broad.mit.edu	37	12	49428364	49428364	+	Splice_Site	SNP	C	C	T			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr12:49428364C>T	uc001rta.3	-	36	10440	c.10440_splice	c.e36+1	p.Q3480_splice		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2						chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TGACCACTTACCTGGCCACTC	0.562		NA	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			4	11					0	0	0	0
KCNH3	23416	broad.mit.edu	37	12	49934900	49934900	+	Silent	SNP	C	C	T			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr12:49934900C>T	uc001ruh.1	+	2	555	c.295C>T	c.(295-297)CTG>TTG	p.L99L	KCNH3_uc010smj.1_Silent_p.L39L	NM_012284	NP_036416	Q9ULD8	KCNH3_HUMAN	potassium voltage-gated channel, subfamily H	99	PAC.|Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	two-component sensor activity|voltage-gated potassium channel activity				0						TGAGCTGATCCTGTACCGGAA	0.622		NA											5	45					0	0	0	0
PA2G4	5036	broad.mit.edu	37	12	56504208	56504208	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr12:56504208G>A	uc001sjm.2	+	8	1074	c.655G>A	c.(655-657)GAG>AAG	p.E219K	PA2G4_uc009zol.2_Missense_Mutation_p.E219K|PA2G4_uc009zom.2_Missense_Mutation_p.E219K	NM_006191	NP_006182	Q9UQ80	PA2G4_HUMAN	ErbB3-binding protein 1	219					cell cycle arrest|cell proliferation|negative regulation of transcription, DNA-dependent|regulation of translation|rRNA processing	cytoplasm|nucleolus|ribonucleoprotein complex	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|ubiquitin protein ligase binding				0			OV - Ovarian serous cystadenocarcinoma(18;0.0739)			AGCTGAATTTGAGGTACATGA	0.343		NA											7	55					0	0	0	0
ZFC3H1	196441	broad.mit.edu	37	12	72056924	72056924	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr12:72056924C>A	uc001swo.2	-	1	826	c.467G>T	c.(466-468)CGC>CTC	p.R156L	ZFC3H1_uc010sts.1_Missense_Mutation_p.R156L|ZFC3H1_uc001swp.2_Missense_Mutation_p.R156L|THAP2_uc001swq.2_5'Flank	NM_144982	NP_659419	O60293	ZC3H1_HUMAN	proline/serine-rich coiled-coil 2	156					RNA processing	intracellular	metal ion binding			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5						CCGACTCCAGCGACTCCCACC	0.667		NA											13	126					0.000308642	0.000324829	1	0
OAS3	4940	broad.mit.edu	37	12	113388618	113388618	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr12:113388618G>A	uc001tug.2	+	7	1582	c.1495G>A	c.(1495-1497)GAG>AAG	p.E499K		NM_006187	NP_006178	Q9Y6K5	OAS3_HUMAN	2'-5'oligoadenylate synthetase 3	499	OAS domain 2.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	microsome	ATP binding|nucleotidyltransferase activity|RNA binding			central_nervous_system(1)	1						GATCCTTGATGAGATGCGAGC	0.572		NA											32	55					0	0	0	0
N4BP2L2	10443	broad.mit.edu	37	13	33017607	33017607	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr13:33017607T>A	uc010abe.1	-	7	1089	c.1067A>T	c.(1066-1068)TAT>TTT	p.Y356F	N4BP2L2_uc001uug.2_Missense_Mutation_p.Y239F|N4BP2L2_uc010abd.1_Missense_Mutation_p.Y269F|N4BP2L2_uc001uuh.2_Missense_Mutation_p.Y187F|N4BP2L2_uc001uuj.2_Intron|N4BP2L2_uc010tdz.1_Missense_Mutation_p.Y341F	NM_033111	NP_149102	Q92802	N42L2_HUMAN	phosphonoformate immuno-associated protein 5	Error:Variant_position_missing_in_Q92802_after_alignment											0		Lung SC(185;0.0262)		all cancers(112;9.5e-07)|Epithelial(112;5.07e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00196)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.243)		TTTAGTTGTATACACTTGTTC	0.378		NA											6	18					0	0	0	0
MYCBP2	23077	broad.mit.edu	37	13	77751900	77751900	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr13:77751900C>T	uc001vkf.2	-	36	5300	c.5209G>A	c.(5209-5211)GAG>AAG	p.E1737K	MYCBP2_uc010aev.2_Missense_Mutation_p.E1141K	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	1737					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		ACCAACACCTCTAATTCATAT	0.398		NA											20	16					0	0	0	0
FLJ10357	55701	broad.mit.edu	37	14	21543067	21543067	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr14:21543067G>T	uc001vzp.2	+	3	1207	c.1178G>T	c.(1177-1179)CGA>CTA	p.R393L	FLJ10357_uc001vzn.1_Missense_Mutation_p.R393L|FLJ10357_uc001vzo.1_Intron|FLJ10357_uc010aij.2_RNA|FLJ10357_uc010tln.1_5'UTR	NM_018071	NP_060541	Q8TER5	ARH40_HUMAN	hypothetical protein LOC55701	393	Gly-rich.				regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity				0	all_cancers(95;0.00185)		OV - Ovarian serous cystadenocarcinoma(11;5.79e-11)|Epithelial(56;8.35e-09)|all cancers(55;4.23e-08)	GBM - Glioblastoma multiforme(265;0.0197)		GCTCTTAGCCGAGGAGGGGAC	0.607		NA											13	32					2.62e-11	3.1e-11	1	0
LRFN5	145581	broad.mit.edu	37	14	42356226	42356226	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr14:42356226A>G	uc001wvm.2	+	3	1596	c.398A>G	c.(397-399)AAT>AGT	p.N133S	LRFN5_uc010ana.2_Missense_Mutation_p.N133S	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	133	Extracellular (Potential).|LRR 4.					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		CTGAACAACAATCAGCTGACT	0.373		NA								HNSCC(30;0.082)			15	47					0	0	0	0
DAAM1	23002	broad.mit.edu	37	14	59798071	59798071	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr14:59798071C>G	uc001xdz.1	+	14	1830	c.1705C>G	c.(1705-1707)CTC>GTC	p.L569V	DAAM1_uc001xea.1_Missense_Mutation_p.L569V	NM_014992	NP_055807	Q9Y4D1	DAAM1_HUMAN	dishevelled-associated activator of	569	FH1.|Pro-rich.				actin cytoskeleton organization	cytoplasm|plasma membrane	actin binding|Rho GTPase binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.165)		accgcctcccctccctccagg	0.453		NA											8	19					0	0	0	0
SPTB	6710	broad.mit.edu	37	14	65242099	65242099	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr14:65242099C>A	uc001xht.2	-	22	4640	c.4586G>T	c.(4585-4587)GGC>GTC	p.G1529V	SPTB_uc001xhr.2_Missense_Mutation_p.G1529V|SPTB_uc001xhs.2_Missense_Mutation_p.G1529V|SPTB_uc001xhu.2_Missense_Mutation_p.G1529V|SPTB_uc010aqi.2_Missense_Mutation_p.G190V	NM_000347	NP_000338	P11277	SPTB1_HUMAN	spectrin beta isoform b	1529	Spectrin 12.				actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		CGGCGTATGGCCCAGAATCTC	0.662		NA											15	13					1.15e-07	1.29e-07	1	0
MAX	4149	broad.mit.edu	37	14	65544653	65544653	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr14:65544653C>G	uc001xif.1	-	4	443	c.273G>C	c.(271-273)CAG>CAC	p.Q91H	MAX_uc001xic.1_Intron|MAX_uc001xie.1_Missense_Mutation_p.Q91H|MAX_uc010aql.1_Intron|MAX_uc001xig.1_Missense_Mutation_p.Q82H|MAX_uc001xih.1_RNA|MAX_uc001xii.1_Missense_Mutation_p.Q82H|MAX_uc001xij.1_Missense_Mutation_p.Q91H	NM_002382	NP_002373	P61244	MAX_HUMAN	MAX protein isoform a	91	Leucine-zipper.				transcription from RNA polymerase II promoter	cytoplasm|MLL1 complex	sequence-specific DNA binding transcription factor activity|transcription coactivator activity			lung(1)	1				all cancers(60;0.000776)|OV - Ovarian serous cystadenocarcinoma(108;0.00359)|BRCA - Breast invasive adenocarcinoma(234;0.00999)		GAAGAGCATTCTGCCGCTTGA	0.567		NA											18	32					0	0	0	0
SLC12A6	9990	broad.mit.edu	37	15	34628812	34628812	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr15:34628812C>G	uc001zhw.2	-	1	234	c.70G>C	c.(70-72)GAC>CAC	p.D24H	SLC12A6_uc001zhx.2_Missense_Mutation_p.D24H|SLC12A6_uc001zhy.2_RNA|SLC12A6_uc001zhz.2_RNA|SLC12A6_uc001zia.2_Intron|SLC12A6_uc001zib.2_Missense_Mutation_p.D15H|SLC12A6_uc001zic.2_Missense_Mutation_p.D24H|SLC12A6_uc010bau.2_Missense_Mutation_p.D24H|SLC12A6_uc001zid.2_Intron	NM_133647	NP_598408	Q9UHW9	S12A6_HUMAN	solute carrier family 12, member 6 isoform a	24	Cytoplasmic (Potential).				angiogenesis|cellular hypotonic salinity response|potassium ion transport|sodium ion transport	basolateral plasma membrane|integral to membrane	potassium:chloride symporter activity			central_nervous_system(5)|ovary(1)|skin(1)	7		all_lung(180;2.78e-08)		all cancers(64;3.43e-17)|GBM - Glioblastoma multiforme(113;2.6e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0301)	Potassium Chloride(DB00761)	CCTGGAATGTCATCGATCTTT	0.488		NA											14	21					0	0	0	0
PRSS22	64063	broad.mit.edu	37	16	2905798	2905798	+	Silent	SNP	C	C	T			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr16:2905798C>T	uc002cry.1	-	4	402	c.336G>A	c.(334-336)GGG>GGA	p.G112G	PRSS22_uc002crz.1_Intron	NM_022119	NP_071402	Q9GZN4	BSSP4_HUMAN	protease, serine, 22 precursor	112	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			central_nervous_system(1)	1						AGCCAGGGTTCCCCAGCTGCC	0.617		NA											6	28					0	0	0	0
COG7	91949	broad.mit.edu	37	16	23444886	23444886	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr16:23444886G>C	uc002dlo.2	-	6	978	c.790C>G	c.(790-792)CAA>GAA	p.Q264E		NM_153603	NP_705831	P83436	COG7_HUMAN	component of oligomeric golgi complex 7	264					intracellular protein transport|protein glycosylation|protein localization in Golgi apparatus|protein stabilization|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding				0				GBM - Glioblastoma multiforme(48;0.0401)		CACTGGATTTGTGTGTGCCAA	0.547		NA											3	40					0	0	0	0
GTF3C1	2975	broad.mit.edu	37	16	27472703	27472703	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr16:27472703C>T	uc002dov.1	-	37	6338	c.6298G>A	c.(6298-6300)GAG>AAG	p.E2100K	GTF3C1_uc002dou.2_Missense_Mutation_p.E2075K	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	2100						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						CAGTTGACCTCGTGGGGGAAC	0.652		NA											10	40					0	0	0	0
ZNF768	79724	broad.mit.edu	37	16	30537124	30537124	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr16:30537124C>T	uc002dyk.3	-	2	513	c.337G>A	c.(337-339)GAG>AAG	p.E113K	ZNF768_uc010vex.1_Missense_Mutation_p.E82K|uc002dyl.1_5'Flank|ZNF768_uc010vew.1_Missense_Mutation_p.E82K	NM_024671	NP_078947	Q9H5H4	ZN768_HUMAN	zinc finger protein 768	113	Pro-rich.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	DNA binding|zinc ion binding				0						GATTCAAACTCAGGGCTCTGA	0.587		NA											14	60					0	0	0	0
ZNF768	79724	broad.mit.edu	37	16	30537662	30537662	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr16:30537662C>G	uc002dyk.3	-	1	249	c.73G>C	c.(73-75)GAA>CAA	p.E25Q	ZNF768_uc010vex.1_Intron|uc002dyl.1_5'Flank|ZNF768_uc010vew.1_Intron	NM_024671	NP_078947	Q9H5H4	ZN768_HUMAN	zinc finger protein 768	25					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	DNA binding|zinc ion binding				0						AGGTACCCTTCGGGGCTCCTC	0.711		NA											4	22					0	0	0	0
ZNF768	79724	broad.mit.edu	37	16	30537672	30537672	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr16:30537672C>T	uc002dyk.3	-	1	239	c.63G>A	c.(61-63)ATG>ATA	p.M21I	ZNF768_uc010vex.1_Intron|uc002dyl.1_5'Flank|ZNF768_uc010vew.1_Intron	NM_024671	NP_078947	Q9H5H4	ZN768_HUMAN	zinc finger protein 768	21					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	DNA binding|zinc ion binding				0						CGGGGCTCCTCATTTCGTCAG	0.701		NA											5	23					0	0	0	0
MMP2	4313	broad.mit.edu	37	16	55523685	55523685	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr16:55523685A>G	uc002ehz.3	+	7	1440	c.1129A>G	c.(1129-1131)ACC>GCC	p.T377A	MMP2_uc010vhd.1_Missense_Mutation_p.T301A|MMP2_uc010ccc.2_Missense_Mutation_p.T327A	NM_004530	NP_004521	P08253	MMP2_HUMAN	matrix metalloproteinase 2 isoform a	377	Fibronectin type-II 3.|Collagen-binding.				angiogenesis|collagen catabolic process|proteolysis	extracellular space|membrane|nucleus|proteinaceous extracellular matrix	metalloendopeptidase activity|protein binding|zinc ion binding			large_intestine(3)|ovary(3)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	11		Renal(780;0.00183)|Breast(268;0.00354)|Hepatocellular(780;0.00826)|all_neural(199;0.0189)		UCEC - Uterine corpus endometrioid carcinoma (183;0.0185)|all cancers(182;7.16e-45)|Epithelial(162;5.26e-37)|GBM - Glioblastoma multiforme(240;9e-08)|Kidney(780;0.00227)|BRCA - Breast invasive adenocarcinoma(181;0.00786)	Marimastat(DB00786)|Sulindac(DB00605)	GTGGTGTGCGACCACAGCCAA	0.592		NA											8	56					0	0	0	0
DYNLRB2	83657	broad.mit.edu	37	16	80583380	80583380	+	Splice_Site	SNP	G	G	C			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr16:80583380G>C	uc002ffo.2	+	5	200	c.80_splice	c.e5-1	p.G27_splice	DYNLRB2_uc002ffp.2_Splice_Site|DYNLRB2_uc002ffq.2_RNA	NM_130897	NP_570967	Q8TF09	DLRB2_HUMAN	dynein, light chain, roadblock-type 2						microtubule-based movement|transport	cytoplasmic dynein complex|microtubule	microtubule motor activity				0						TTTCATAATAGGTATTCCCAT	0.338		NA											4	20					0	0	0	0
KIAA0664	23277	broad.mit.edu	37	17	2604528	2604528	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr17:2604528C>T	uc002fuy.1	-	7	903	c.817G>A	c.(817-819)GCC>ACC	p.A273T	KIAA0664_uc002fux.1_Missense_Mutation_p.A205T	NM_015229	NP_056044	O75153	K0664_HUMAN	hypothetical protein LOC23277	273							binding			breast(2)	2						CGGGGGCTGGCGGGCTTGGGG	0.622		NA											5	17					0	0	0	0
MYBBP1A	10514	broad.mit.edu	37	17	4455195	4455195	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr17:4455195C>T	uc002fyb.3	-	8	1065	c.1003G>A	c.(1003-1005)GAG>AAG	p.E335K	MYBBP1A_uc002fxz.3_Missense_Mutation_p.E335K	NM_014520	NP_055335	Q9BQG0	MBB1A_HUMAN	MYB binding protein 1a isoform 2	335	Interaction with MYB (By similarity).				nucleocytoplasmic transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NLS-dependent protein nuclear import complex|nucleolus	DNA binding|DNA-directed DNA polymerase activity|transcription factor binding			ovary(1)|skin(1)	2						CACACGTGCTCCCCGTAATGG	0.627		NA											6	74					0	0	0	0
MINK1	50488	broad.mit.edu	37	17	4789867	4789867	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr17:4789867C>T	uc010vsl.1	+	10	1091	c.895C>T	c.(895-897)CGC>TGC	p.R299C	MINK1_uc010vsk.1_Missense_Mutation_p.R299C|MINK1_uc010vsm.1_Missense_Mutation_p.R299C|MINK1_uc010vsn.1_Missense_Mutation_p.R299C|MINK1_uc010vso.1_Missense_Mutation_p.R244C|MINK1_uc010vsp.1_5'UTR	NM_153827	NP_722549	Q8N4C8	MINK1_HUMAN	misshapen-like kinase 1 isoform 3	299					JNK cascade	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			central_nervous_system(2)|stomach(1)|large_intestine(1)|lung(1)|skin(1)	6						GCGGCAGGTCCGCATCCAGCT	0.602		NA											20	46					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7577548	7577548	+	Missense_Mutation	SNP	C	C	T	rs28934575		TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr17:7577548C>T	uc002gim.2	-	7	927	c.733G>A	c.(733-735)GGC>AGC	p.G245S	TP53_uc002gig.1_Missense_Mutation_p.G245S|TP53_uc002gih.2_Missense_Mutation_p.G245S|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.G113S|TP53_uc010cng.1_Missense_Mutation_p.G113S|TP53_uc002gii.1_Missense_Mutation_p.G113S|TP53_uc010cnh.1_Missense_Mutation_p.G245S|TP53_uc010cni.1_Missense_Mutation_p.G245S|TP53_uc002gij.2_Missense_Mutation_p.G245S|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.G152S|TP53_uc002gio.2_Missense_Mutation_p.G113S	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	245	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		G -> N (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> A (in sporadic cancers; somatic mutation).|G -> V (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> F (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> R (in sporadic cancers; somatic mutation).|G -> E (in a sporadic cancer; somatic mutation).|G -> D (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> H (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|G -> L (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.G245S(274)|p.G245D(93)|p.G245V(50)|p.G245C(47)|p.G245R(10)|p.G245A(8)|p.0?(7)|p.G245G(3)|p.G245fs*2(3)|p.G245N(2)|p.G245H(1)|p.G245L(1)|p.G244fs*17(1)|p.G245F(1)|p.G245E(1)|p.C242_M246>L(1)|p.C238_M246delCNSSCMGGM(1)|p.S241_G245delSCMGG(1)|p.C242fs*98(1)|p.G245fs*22(1)|p.M243fs*18(1)|p.G245del(1)|p.G245fs*14(1)|p.G245fs*17(1)|p.G245fs*16(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CGGTTCATGCCGCCCATGCAG	0.577	G245S(SKLMS1_SOFT_TISSUE)|G245S(LS1034_LARGE_INTESTINE)|G245S(NUGC2_STOMACH)|G245S(PANC0403_PANCREAS)|G245S(SKMEL2_SKIN)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			15	21					0	0	0	0
PHF12	57649	broad.mit.edu	37	17	27248731	27248731	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr17:27248731C>A	uc002hdg.1	-	5	1341	c.811G>T	c.(811-813)GTC>TTC	p.V271F	PHF12_uc010wbb.1_Missense_Mutation_p.V253F|PHF12_uc002hdi.1_Missense_Mutation_p.V267F|PHF12_uc002hdj.1_Missense_Mutation_p.V271F|PHF12_uc010crw.1_5'UTR|PHF12_uc002hdh.1_Missense_Mutation_p.V54F	NM_001033561	NP_001028733	Q96QT6	PHF12_HUMAN	PHD finger protein 12 isoform 1	271	PHD-type 2; atypical.|Interaction with SIN3A.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	protein binding|zinc ion binding			ovary(1)	1	all_cancers(5;1.95e-14)|all_epithelial(6;5e-18)|Lung NSC(42;0.01)		Epithelial(11;1.64e-05)|all cancers(11;7.47e-05)|BRCA - Breast invasive adenocarcinoma(11;9.79e-05)			CAGACTTTGACGGGTAAGGGA	0.408		NA											29	73					2.71e-09	3.16e-09	1	0
MYO1D	4642	broad.mit.edu	37	17	31094761	31094761	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr17:31094761T>C	uc002hho.1	-	7	736	c.724A>G	c.(724-726)AAT>GAT	p.N242D	MYO1D_uc002hhp.1_Missense_Mutation_p.N242D|MYO1D_uc010wcb.1_Missense_Mutation_p.N242D	NM_015194	NP_056009	O94832	MYO1D_HUMAN	myosin ID	242	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3			BRCA - Breast invasive adenocarcinoma(9;0.0362)			GCAGCATCATTGATAGAAGAC	0.353		NA											24	39					0	0	0	0
RFFL	117584	broad.mit.edu	37	17	33353416	33353416	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr17:33353416G>C	uc002hin.1	-	2	330	c.157C>G	c.(157-159)CAC>GAC	p.H53D	RFFL_uc002hiq.2_Intron|RFFL_uc002him.1_Missense_Mutation_p.H53D|RFFL_uc010cti.1_Missense_Mutation_p.H59D|RFFL_uc002hip.1_Missense_Mutation_p.H53D|RFFL_uc002hio.1_Missense_Mutation_p.H53D	NM_001017368	NP_001017368	Q8WZ73	RFFL_HUMAN	rififylin	53	FYVE-type.				apoptosis	membrane	ligase activity|zinc ion binding				0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)		TTTGCAAAGTGAGCCCCACAG	0.597		NA											6	24					0	0	0	0
CCL23	6368	broad.mit.edu	37	17	34340266	34340266	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr17:34340266C>T	uc002hkt.1	-	4	405	c.334G>A	c.(334-336)GAC>AAC	p.D112N	CCL23_uc002hks.1_Missense_Mutation_p.D129N	NM_145898	NP_665905	P55773	CCL23_HUMAN	small inducible cytokine A23 isoform CKbeta8	112					cell-cell signaling|cellular calcium ion homeostasis|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|inflammatory response|negative regulation of cell proliferation	extracellular space	chemokine activity|heparin binding				0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)	Treprostinil(DB00374)	ATCCGTGTGTCCAGCTTCAGC	0.498		NA											6	33					0	0	0	0
TEX2	55852	broad.mit.edu	37	17	62248511	62248511	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr17:62248511C>G	uc002jec.2	-	7	2793	c.2620G>C	c.(2620-2622)GTG>CTG	p.V874L	TEX2_uc002jed.2_Missense_Mutation_p.V881L|TEX2_uc002jee.2_Missense_Mutation_p.V874L	NM_018469	NP_060939	Q8IWB9	TEX2_HUMAN	testis expressed sequence 2	874					signal transduction|sphingolipid metabolic process	integral to membrane				ovary(1)	1			BRCA - Breast invasive adenocarcinoma(8;1.33e-10)	READ - Rectum adenocarcinoma(1115;0.0689)		GGCACAGCCACGCCCATGTCA	0.448		NA											5	35					0	0	0	0
RFNG	5986	broad.mit.edu	37	17	80007651	80007651	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr17:80007651C>T	uc002kdj.2	-	6	738	c.730G>A	c.(730-732)GTG>ATG	p.V244M	RFNG_uc002kdh.2_Missense_Mutation_p.V29M|GPS1_uc002kdk.1_5'Flank|GPS1_uc002kdl.1_5'Flank|GPS1_uc010dij.1_5'Flank|GPS1_uc002kdm.1_5'Flank|GPS1_uc002kdn.1_5'Flank|GPS1_uc002kdo.1_5'Flank|GPS1_uc010wvh.1_5'Flank	NM_002917	NP_002908	Q9Y644	RFNG_HUMAN	radical fringe	244	Lumenal (Potential).				cell differentiation|nervous system development|organ morphogenesis|pattern specification process	extracellular region|integral to Golgi membrane	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity			central_nervous_system(1)	1	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0211)			AGCCCCTCCACGATGTAGCCA	0.667		NA											7	18					0	0	0	0
CCDC57	284001	broad.mit.edu	37	17	80129690	80129690	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr17:80129690T>C	uc002kdz.1	-	13	2124	c.1769A>G	c.(1768-1770)AAG>AGG	p.K590R	CCDC57_uc002kdx.1_Missense_Mutation_p.K590R|CCDC57_uc010dik.1_Missense_Mutation_p.K98R	NM_198082	NP_932348	Q2TAC2	CCD57_HUMAN	coiled-coil domain containing 57	590	Potential.									ovary(2)	2	Breast(20;0.00285)|all_neural(118;0.0878)|all_lung(278;0.0949)|Lung NSC(278;0.128)|Ovarian(332;0.227)		BRCA - Breast invasive adenocarcinoma(99;0.0232)|OV - Ovarian serous cystadenocarcinoma(97;0.0253)			AAACTTATGCTTTAGAGTTCG	0.448		NA											19	68					0	0	0	0
PTPN2	5771	broad.mit.edu	37	18	12817283	12817283	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr18:12817283G>A	uc002krp.2	-	6	771	c.577C>T	c.(577-579)CTC>TTC	p.L193F	PTPN2_uc002krl.2_Missense_Mutation_p.L193F|PTPN2_uc002krn.2_Missense_Mutation_p.L216F|PTPN2_uc002kro.2_Missense_Mutation_p.L193F|PTPN2_uc002krm.2_Missense_Mutation_p.L193F	NM_002828	NP_002819	P17706	PTN2_HUMAN	protein tyrosine phosphatase, non-receptor type	193	Tyrosine-protein phosphatase.				interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway	endoplasmic reticulum|nucleoplasm	protein binding			skin(2)	2		Lung NSC(161;8.94e-06)				AAGAAATTGAGAAATGAAGCT	0.453		NA											19	64					0	0	0	0
CHST9	83539	broad.mit.edu	37	18	24497019	24497019	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr18:24497019C>A	uc002kwd.2	-	5	734	c.536G>T	c.(535-537)AGG>ATG	p.R179M	C18orf16_uc002kwb.2_Intron|C18orf16_uc010xbm.1_Intron|CHST9_uc002kwc.2_Missense_Mutation_p.R94M|CHST9_uc002kwe.2_Missense_Mutation_p.R179M	NM_031422	NP_113610	Q7L1S5	CHST9_HUMAN	GalNAc-4-sulfotransferase 2	179	Lumenal (Potential).				carbohydrate biosynthetic process|glycosaminoglycan metabolic process|hormone biosynthetic process|proteoglycan biosynthetic process|sulfur compound metabolic process	extracellular region|Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity			ovary(2)|skin(1)	3	all_lung(6;0.0145)|Ovarian(20;0.124)					AAGGAAAGACCTTCGTTTCTC	0.383		NA											17	82					1.15e-07	1.29e-07	1	0
HNRNPL	3191	broad.mit.edu	37	19	39329127	39329127	+	Silent	SNP	C	C	T			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr19:39329127C>T	uc010xul.1	-	10	1478	c.1467G>A	c.(1465-1467)GAG>GAA	p.E489E	HNRNPL_uc010ege.1_Intron|HNRNPL_uc002ojj.1_Silent_p.E145E|HNRNPL_uc002ojo.1_Silent_p.E67E|HNRNPL_uc002ojk.2_Silent_p.E145E|HNRNPL_uc002ojl.2_Silent_p.E145E|HNRNPL_uc010xum.1_Silent_p.E356E	NM_001533	NP_001524	P14866	HNRPL_HUMAN	heterogeneous nuclear ribonucleoprotein L	489					nuclear mRNA splicing, via spliceosome	cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding|transcription regulatory region DNA binding				0	all_cancers(60;6.83e-06)|Ovarian(47;0.0454)		Lung(45;0.00342)|LUSC - Lung squamous cell carcinoma(53;0.00575)			TGGCTGCCTGCTCTGGGGTGG	0.572		NA											5	21					0	0	0	0
HNRNPUL1	11100	broad.mit.edu	37	19	41807560	41807560	+	Silent	SNP	C	C	T			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr19:41807560C>T	uc002oqb.3	+	11	1927	c.1638C>T	c.(1636-1638)ACC>ACT	p.T546T	CYP2F1_uc010xvw.1_Intron|HNRNPUL1_uc002opz.3_Silent_p.T446T|HNRNPUL1_uc002oqa.3_Silent_p.T446T|HNRNPUL1_uc010ehm.2_Silent_p.T546T|HNRNPUL1_uc002oqc.3_Silent_p.T432T|HNRNPUL1_uc002oqe.3_Intron|HNRNPUL1_uc002oqd.3_Silent_p.T446T|HNRNPUL1_uc010ehn.2_Silent_p.T446T|HNRNPUL1_uc010eho.2_Silent_p.T446T|HNRNPUL1_uc010xvy.1_Silent_p.T446T|HNRNPUL1_uc010ehp.2_Silent_p.T402T|HNRNPUL1_uc002oqf.3_5'Flank	NM_007040	NP_008971	Q9BUJ2	HNRL1_HUMAN	heterogeneous nuclear ribonucleoprotein U-like 1	546	Necessary for interaction with TP53.|Necessary for interaction with BRD7 and transcriptional activation.				nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	enzyme binding|RNA binding			central_nervous_system(1)|skin(1)	2						TAAAGCGAACCGACGAGGAAG	0.483		NA											9	53					0	0	0	0
NT5C1B	93034	broad.mit.edu	37	2	18767631	18767631	+	Silent	SNP	C	C	T			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr2:18767631C>T	uc002rcz.2	-	4	431	c.327G>A	c.(325-327)AAG>AAA	p.K109K	NT5C1B_uc002rcy.2_Silent_p.K109K|NT5C1B_uc010exr.2_Silent_p.K49K|NT5C1B_uc010yju.1_Silent_p.K49K|NT5C1B_uc002rda.2_Silent_p.K49K|NT5C1B_uc010yjv.1_Silent_p.K126K|NT5C1B_uc010yjw.1_Silent_p.K92K|NT5C1B_uc010exs.2_Silent_p.K109K|NT5C1B_uc002rdb.1_5'Flank	NM_001002006	NP_001002006	Q96P26	5NT1B_HUMAN	5' nucleotidase, cytosolic IB isoform 1	109	Ser-rich.				purine base metabolic process|purine nucleotide catabolic process	cytosol	5'-nucleotidase activity|magnesium ion binding|nucleotide binding			skin(2)|ovary(1)	3	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				GAGAGTCTGTCTTCCGCAGTG	0.498		NA											6	46					0	0	0	0
HADHA	3030	broad.mit.edu	37	2	26438045	26438045	+	Splice_Site	SNP	C	C	T			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr2:26438045C>T	uc002rgy.2	-	8	807	c.677_splice	c.e8-1	p.G226_splice	HADHA_uc010yks.1_Splice_Site_p.G139_splice|HADHA_uc010ykt.1_Splice_Site_p.G139_splice	NM_000182	NP_000173	P40939	ECHA_HUMAN	mitochondrial trifunctional protein, alpha						fatty acid beta-oxidation	fatty acid beta-oxidation multienzyme complex|mitochondrial nucleoid|nucleolus	3-hydroxyacyl-CoA dehydrogenase activity|acetyl-CoA C-acetyltransferase activity|coenzyme binding|enoyl-CoA hydratase activity|long-chain-3-hydroxyacyl-CoA dehydrogenase activity|protein binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				NADH(DB00157)	AGTCCTGGTCCTATAAAAATG	0.438		NA											23	105					0	0	0	0
ALK	238	broad.mit.edu	37	2	29456500	29456500	+	Silent	SNP	A	A	T			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr2:29456500A>T	uc002rmy.2	-	14	3325	c.2418T>A	c.(2416-2418)CGT>CGA	p.R806R		NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	806	Extracellular (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	TTCTGTTCACACGGATTTCTT	0.488		NA	T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				26	70					0	0	0	0
ALMS1	7840	broad.mit.edu	37	2	73717132	73717132	+	Silent	SNP	A	A	G			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr2:73717132A>G	uc002sje.1	+	12	8160	c.8049A>G	c.(8047-8049)GAA>GAG	p.E2683E	ALMS1_uc002sjf.1_Silent_p.E2639E|ALMS1_uc002sjg.2_Silent_p.E2069E|ALMS1_uc002sjh.1_Silent_p.E2069E	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	2681					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						GGCTGTCAGAATTAGTAGAAC	0.403		NA											24	143					0	0	0	0
SLC9A2	6549	broad.mit.edu	37	2	103321047	103321047	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr2:103321047G>C	uc002tca.2	+	10	2032	c.1890G>C	c.(1888-1890)GAG>GAC	p.E630D		NM_003048	NP_003039	Q9UBY0	SL9A2_HUMAN	solute carrier family 9 (sodium/hydrogen	630	Cytoplasmic (Potential).					integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			central_nervous_system(3)|skin(3)|breast(2)	8						ACACAAGTGAGAGACAAGCCA	0.428		NA											5	28					0	0	0	0
GCC2	9648	broad.mit.edu	37	2	109088215	109088215	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr2:109088215G>C	uc002tec.2	+	6	2584	c.2430G>C	c.(2428-2430)GAG>GAC	p.E810D	GCC2_uc002ted.2_Missense_Mutation_p.E709D	NM_181453	NP_852118	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain-containing 2	810	Potential.				Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			ovary(1)	1						AAGTATTAGAGTTAGAAAAAG	0.363		NA											18	55					0	0	0	0
SEC23B	10483	broad.mit.edu	37	20	18511339	18511339	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr20:18511339G>T	uc002wqz.1	+	10	1568	c.1125G>T	c.(1123-1125)ATG>ATT	p.M375I	SEC23B_uc002wra.1_Missense_Mutation_p.M375I|SEC23B_uc002wrb.1_Missense_Mutation_p.M375I|SEC23B_uc010zsb.1_Missense_Mutation_p.M357I|SEC23B_uc002wrc.1_Missense_Mutation_p.M375I	NM_006363	NP_006354	Q15437	SC23B_HUMAN	Sec23 homolog B	375					ER to Golgi vesicle-mediated transport|intracellular protein transport	COPII vesicle coat|endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane	zinc ion binding			ovary(1)	1						ACATGGTAATGGGAGATTCTT	0.343		NA											6	73					1.07e-07	1.21e-07	1	0
NDRG3	57446	broad.mit.edu	37	20	35293461	35293461	+	Silent	SNP	T	T	G			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr20:35293461T>G	uc002xfw.2	-	12	880	c.798A>C	c.(796-798)GCA>GCC	p.A266A	NDRG3_uc002xfx.2_Silent_p.A254A|NDRG3_uc010zvq.1_Silent_p.A171A|NDRG3_uc010zvr.1_Silent_p.A154A	NM_032013	NP_114402	Q9UGV2	NDRG3_HUMAN	N-myc downstream regulated gene 3 isoform a	266					cell differentiation|negative regulation of cell growth|spermatogenesis	cytoplasm				ovary(1)	1		Myeloproliferative disorder(115;0.00878)				CAGCCTCAACTGCAGGCGAAT	0.358		NA											46	93					0	0	0	0
C20orf132	140699	broad.mit.edu	37	20	35757571	35757571	+	Splice_Site	SNP	C	C	G			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr20:35757571C>G	uc010zvu.1	-	16	1771	c.1680_splice	c.e16-1	p.R560_splice	C20orf132_uc002xgk.2_Splice_Site_p.R182_splice|C20orf132_uc002xgm.2_Intron|C20orf132_uc002xgn.2_Intron	NM_152503	NP_689716	Q9H579	CT132_HUMAN	hypothetical protein LOC140699 isoform 1												0		Myeloproliferative disorder(115;0.00878)				AGCCAGGTGCCTGGAAATCCC	0.512		NA											10	14					0	0	0	0
CHD6	84181	broad.mit.edu	37	20	40040857	40040857	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr20:40040857G>C	uc002xka.1	-	36	7356	c.7178C>G	c.(7177-7179)CCT>CGT	p.P2393R	CHD6_uc002xjz.1_5'UTR	NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	2393					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				TAATTTTCCAGGTTCTTTACA	0.488		NA											11	70					0	0	0	0
LMCD1	29995	broad.mit.edu	37	3	8579047	8579047	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr3:8579047A>G	uc003bqq.2	+	3	422	c.308A>G	c.(307-309)AAC>AGC	p.N103S	LMCD1_uc011atd.1_Missense_Mutation_p.N30S|LMCD1_uc011ate.1_Intron|LMCD1_uc011atf.1_Missense_Mutation_p.N30S	NM_014583	NP_055398	Q9NZU5	LMCD1_HUMAN	LIM and cysteine-rich domains 1	103	PET.				positive regulation of calcineurin-NFAT signaling pathway|regulation of cardiac muscle hypertrophy|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus	transcription corepressor activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(96;0.124)		ATCATGACCAACCCTATTGCT	0.552		NA											10	138					0	0	0	0
ZNF445	353274	broad.mit.edu	37	3	44488834	44488834	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr3:44488834G>C	uc003cnf.2	-	8	2677	c.2329C>G	c.(2329-2331)CTC>GTC	p.L777V	ZNF445_uc011azv.1_Missense_Mutation_p.L765V|ZNF445_uc011azw.1_Missense_Mutation_p.L777V	NM_181489	NP_852466	P59923	ZN445_HUMAN	zinc finger protein 445	777	C2H2-type 8.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(197;0.0514)|Kidney(197;0.0646)		TGGATGAGGAGGAATGAGTGA	0.512		NA											21	20					0	0	0	0
CCDC36	339834	broad.mit.edu	37	3	49293597	49293597	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr3:49293597A>G	uc003cwk.2	+	10	1054	c.667A>G	c.(667-669)AAC>GAC	p.N223D	CCDC36_uc011bck.1_Missense_Mutation_p.N223D	NM_178173	NP_835467	Q8IYA8	CCD36_HUMAN	coiled-coil domain containing 36	223	Potential.									ovary(1)|kidney(1)	2				BRCA - Breast invasive adenocarcinoma(193;9.11e-05)|Kidney(197;0.00248)|KIRC - Kidney renal clear cell carcinoma(197;0.00262)		AATGAAGTCCAACCTGAAGCA	0.473		NA											34	58					0	0	0	0
BSN	8927	broad.mit.edu	37	3	49699628	49699628	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr3:49699628T>G	uc003cxe.3	+	6	10464	c.10350T>G	c.(10348-10350)AGT>AGG	p.S3450R		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	3450					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		CTGCATACAGTGGGGAGAAGC	0.607		NA											5	36					0	0	0	0
A4GNT	51146	broad.mit.edu	37	3	137843343	137843343	+	Silent	SNP	G	G	T			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr3:137843343G>T	uc003ers.2	-	3	988	c.786C>A	c.(784-786)CCC>CCA	p.P262P		NM_016161	NP_057245	Q9UNA3	A4GCT_HUMAN	alpha-1,4-N-acetylglucosaminyltransferase	262	Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|Golgi stack|integral to membrane|membrane fraction	acetylglucosaminyltransferase activity|galactosyltransferase activity			central_nervous_system(1)	1						GATAGGAGATGGGGTAAAATC	0.483		NA											11	79					0.000151284	0.000162631	1	0
MRPS22	56945	broad.mit.edu	37	3	139067116	139067116	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr3:139067116G>A	uc003etb.2	+	3	462	c.454G>A	c.(454-456)GAA>AAA	p.E152K	MRPS22_uc003etc.2_RNA|MRPS22_uc003etd.2_Missense_Mutation_p.E151K|MRPS22_uc003ete.2_Missense_Mutation_p.E111K	NM_020191	NP_064576	P82650	RT22_HUMAN	mitochondrial ribosomal protein S22	152						mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome			ovary(2)|skin(1)	3						GGAAGGAACAGAAACAACCAA	0.363		NA											38	73					0	0	0	0
ATR	545	broad.mit.edu	37	3	142168296	142168296	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr3:142168296T>C	uc003eux.3	-	47	8032	c.7910A>G	c.(7909-7911)TAT>TGT	p.Y2637C	XRN1_uc003eus.2_5'Flank|XRN1_uc003eut.2_5'Flank|XRN1_uc003euu.2_5'Flank|XRN1_uc003euw.2_5'Flank|XRN1_uc011bnh.1_5'Flank|ATR_uc003euy.1_3'UTR	NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	2637	FATC.				cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20						CCAACCAAGATACATCTGGCA	0.338		NA						Other_conserved_DNA_damage_response_genes					15	91					0	0	0	0
SI	6476	broad.mit.edu	37	3	164786949	164786949	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr3:164786949G>A	uc003fei.2	-	4	352	c.290C>T	c.(289-291)CCG>CTG	p.P97L		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	97	Lumenal.|P-type 1.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	GTCATTCCACGGCCTCCAGCA	0.373		NA								HNSCC(35;0.089)			6	48					0	0	0	0
MASP1	5648	broad.mit.edu	37	3	187003846	187003846	+	Splice_Site	SNP	T	T	A			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr3:187003846T>A	uc003frh.1	-	2	338	c.6_splice	c.e2-1	p.R2_splice	MASP1_uc003fri.2_Splice_Site_p.R2_splice|MASP1_uc003frj.2_Intron|MASP1_uc003frk.1_Splice_Site_p.R2_splice|MASP1_uc011bse.1_Splice_Site	NM_001879	NP_001870	P48740	MASP1_HUMAN	mannan-binding lectin serine protease 1 isoform						complement activation, lectin pathway|negative regulation of complement activation|proteolysis	extracellular space	calcium ion binding|calcium-dependent protein binding|protein binding|protein homodimerization activity|serine-type endopeptidase activity			ovary(2)|breast(1)|liver(1)	4	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.49e-18)	GBM - Glioblastoma multiforme(93;0.0366)		AGCAGCCACCTGAAAGACATG	0.478		NA											13	39					0	0	0	0
ATP13A4	84239	broad.mit.edu	37	3	193175175	193175175	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr3:193175175G>C	uc003ftd.2	-	15	1862	c.1754C>G	c.(1753-1755)GCC>GGC	p.A585G	ATP13A4_uc003fte.1_Missense_Mutation_p.A585G|ATP13A4_uc011bsr.1_Missense_Mutation_p.A56G|ATP13A4_uc010hzi.2_RNA	NM_032279	NP_115655	Q4VNC1	AT134_HUMAN	ATPase type 13A4	585	Extracellular (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(2)	2	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		TACCTGGCTGGCTGTTCTGCA	0.483		NA											19	281					0	0	0	0
LRCH3	84859	broad.mit.edu	37	3	197585726	197585726	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr3:197585726G>C	uc011bul.1	+	15	1671	c.1666G>C	c.(1666-1668)GTG>CTG	p.V556L	LRCH3_uc003fyj.1_Missense_Mutation_p.V556L|LRCH3_uc011bum.1_Intron|LRCH3_uc011bun.1_Missense_Mutation_p.V402L|LRCH3_uc003fyk.2_Missense_Mutation_p.V151L	NM_032773	NP_116162	Q96II8	LRCH3_HUMAN	leucine-rich repeats and calponin homology (CH)	556						extracellular region				ovary(1)	1	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;4.82e-24)|all cancers(36;3.61e-22)|OV - Ovarian serous cystadenocarcinoma(49;7.08e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.119)		GTTGAATCAAGTGGGCTGTGC	0.453		NA											40	134					0	0	0	0
PPARGC1A	10891	broad.mit.edu	37	4	23830203	23830203	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr4:23830203C>T	uc003gqs.2	-	5	697	c.577G>A	c.(577-579)GCG>ACG	p.A193T	PPARGC1A_uc003gqt.2_RNA|PPARGC1A_uc011bxp.1_RNA|PPARGC1A_uc010ier.1_RNA	NM_013261	NP_037393	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor	193					androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			ovary(2)|lung(2)|kidney(2)|skin(2)	8		Breast(46;0.0503)				ATACTCTTCGCTTTATTGCTC	0.413		NA											3	87					0	0	0	0
COX18	285521	broad.mit.edu	37	4	73930982	73930982	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr4:73930982C>A	uc003hgm.1	-	3	689	c.583G>T	c.(583-585)GCA>TCA	p.A195S	COX18_uc003hgn.1_Missense_Mutation_p.A44S|COX18_uc011cbc.1_Missense_Mutation_p.A195S|COX18_uc010iih.1_Missense_Mutation_p.A195S	NM_173827	NP_776188	Q8N8Q8	COX18_HUMAN	mitochondrial COX18 precursor	195					protein insertion into mitochondrial membrane|respiratory chain complex IV assembly	integral to mitochondrial inner membrane	protein transporter activity				0	Breast(15;0.00096)		Epithelial(6;1.26e-06)|OV - Ovarian serous cystadenocarcinoma(6;9.45e-06)|all cancers(17;2.05e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			GAATGTGCTGCCCCCGTGCTT	0.378		NA											17	30					2.35e-11	2.8e-11	1	0
SEC24B	10427	broad.mit.edu	37	4	110384711	110384711	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr4:110384711C>T	uc003hzk.2	+	2	843	c.788C>T	c.(787-789)TCA>TTA	p.S263L	SEC24B_uc003hzl.2_Missense_Mutation_p.S263L|SEC24B_uc011cfp.1_Missense_Mutation_p.S294L|SEC24B_uc011cfq.1_Missense_Mutation_p.S263L|SEC24B_uc011cfr.1_Missense_Mutation_p.S263L	NM_006323	NP_006314	O95487	SC24B_HUMAN	SEC24 (S. cerevisiae) homolog B isoform a	263					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|transporter activity|zinc ion binding			ovary(2)|large_intestine(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.03e-05)		CTAACGTGGTCATCTCCAGGC	0.488		NA											20	40					0	0	0	0
RAI14	26064	broad.mit.edu	37	5	34823598	34823598	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr5:34823598G>C	uc003jir.2	+	15	1847	c.1651G>C	c.(1651-1653)GAG>CAG	p.E551Q	RAI14_uc010iur.2_Missense_Mutation_p.E522Q|RAI14_uc011coj.1_Missense_Mutation_p.E551Q|RAI14_uc003jis.2_Missense_Mutation_p.E554Q|RAI14_uc003jit.2_Missense_Mutation_p.E551Q|RAI14_uc011cok.1_Missense_Mutation_p.E543Q	NM_015577	NP_056392	Q9P0K7	RAI14_HUMAN	retinoic acid induced 14 isoform a	551	Potential.					cell cortex|cytoskeleton	protein binding			ovary(1)	1	all_lung(31;0.000191)					aagaaataaagagaaagtgag	0.274		NA											3	44					0	0	0	0
RASA1	5921	broad.mit.edu	37	5	86670020	86670020	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr5:86670020T>A	uc003kiw.2	+	14	1935	c.1817T>A	c.(1816-1818)CTC>CAC	p.L606H	RASA1_uc010jav.2_RNA|RASA1_uc003kix.2_Missense_Mutation_p.L429H|RASA1_uc011ctv.1_Missense_Mutation_p.L439H|RASA1_uc011ctw.1_Missense_Mutation_p.L440H|RASA1_uc010jaw.2_Missense_Mutation_p.L428H	NM_002890	NP_002881	P20936	RASA1_HUMAN	RAS p21 protein activator 1 isoform 1	606	C2.				cytokinesis|embryo development|intracellular signal transduction|negative regulation of cell-matrix adhesion|negative regulation of neuron apoptosis|negative regulation of Ras protein signal transduction|positive regulation of anti-apoptosis|regulation of actin filament polymerization|regulation of cell shape|regulation of RNA metabolic process|vasculogenesis	cytosol|intrinsic to internal side of plasma membrane	glycoprotein binding|GTPase binding|potassium channel inhibitor activity|Ras GTPase activator activity|receptor binding			upper_aerodigestive_tract(3)|ovary(1)|lung(1)	5		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;4.72e-41)|Epithelial(54;1.51e-36)|all cancers(79;3.76e-31)		GCCCATAAACTCCCAGTAAAA	0.333		NA											7	11					0	0	0	0
RAD50	10111	broad.mit.edu	37	5	131915747	131915747	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr5:131915747G>T	uc003kxi.2	+	5	1132	c.745G>T	c.(745-747)GAT>TAT	p.D249Y	RAD50_uc003kxg.1_Missense_Mutation_p.D150Y|RAD50_uc003kxh.2_Missense_Mutation_p.D110Y	NM_005732	NP_005723	Q92878	RAD50_HUMAN	RAD50 homolog isoform 1	249	Potential.				DNA duplex unwinding|double-strand break repair via homologous recombination|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|telomere maintenance via telomerase	Mre11 complex|nuclear chromosome, telomeric region|nucleoplasm	ATP binding|DNA binding|nuclease activity|protein binding, bridging|zinc ion binding			lung(2)|ovary(1)|skin(1)	4		all_cancers(142;0.0368)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GAATGAACTTGATCCATTGAA	0.209		NA						Homologous_recombination					8	45					5.18e-06	5.63e-06	1	0
SIL1	64374	broad.mit.edu	37	5	138362615	138362615	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr5:138362615G>C	uc003ldm.2	-	5	537	c.520C>G	c.(520-522)CTG>GTG	p.L174V	SIL1_uc003ldn.2_Missense_Mutation_p.L173V|SIL1_uc003ldo.2_Missense_Mutation_p.L174V|SIL1_uc003ldp.2_Missense_Mutation_p.L174V|SIL1_uc003ldq.1_Intron	NM_022464	NP_071909	Q9H173	SIL1_HUMAN	SIL1 protein precursor	174	Interaction with HSPA5 and localization to the endoplasmic reticulum (By similarity).				intracellular protein transport|protein folding|transmembrane transport	endoplasmic reticulum lumen	unfolded protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			ACAACATTCAGCTCATCAAAG	0.468		NA							Marinesco-Sj_gren_syndrome				9	40					0	0	0	0
HIVEP1	3096	broad.mit.edu	37	6	12125603	12125603	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr6:12125603G>A	uc003nac.2	+	4	5754	c.5575G>A	c.(5575-5577)GAA>AAA	p.E1859K	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	1859					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				GCAGGAATTTGAAAACATCAA	0.338		NA											37	44					0	0	0	0
ABCF1	23	broad.mit.edu	37	6	30547713	30547713	+	Silent	SNP	A	A	G			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr6:30547713A>G	uc003nql.2	+	7	590	c.495A>G	c.(493-495)GTA>GTG	p.V165V	ABCF1_uc003nqk.2_Silent_p.V166V|ABCF1_uc003nqm.2_Silent_p.V165V|ABCF1_uc010jsb.2_Intron	NM_001025091	NP_001020262	Q8NE71	ABCF1_HUMAN	ATP-binding cassette, sub-family F, member 1	165	Glu-rich.				inflammatory response|translational initiation	nuclear envelope|nuclear envelope|nucleoplasm|nucleoplasm|polysomal ribosome	ATP binding|ATP binding|ATPase activity|protein binding|ribosome binding|translation activator activity|translation factor activity, nucleic acid binding			ovary(2)	2						TCCAGGCCGTATCTGAGGAAC	0.433		NA											7	8					0	0	0	0
MUC21	394263	broad.mit.edu	37	6	30954739	30954739	+	Missense_Mutation	SNP	A	A	C			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr6:30954739A>C	uc003nsh.2	+	2	1038	c.787A>C	c.(787-789)ACC>CCC	p.T263P	MUC21_uc003nsi.1_RNA	NM_001010909	NP_001010909	Q5SSG8	MUC21_HUMAN	mucin 21 precursor	263	Ser-rich.|16.|28 X 15 AA approximate tandem repeats.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(1)|skin(1)	2						GTCCAGCACGACCTCCAGTGG	0.632		NA											9	177					0	0	0	0
COL21A1	81578	broad.mit.edu	37	6	55922598	55922598	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr6:55922598C>G	uc003pcs.2	-	30	2963	c.2731G>C	c.(2731-2733)GAC>CAC	p.D911H	COL21A1_uc010jzz.2_Missense_Mutation_p.D296H|COL21A1_uc011dxg.1_Missense_Mutation_p.D284H|COL21A1_uc011dxh.1_Missense_Mutation_p.D262H|COL21A1_uc003pcr.2_Missense_Mutation_p.D268H	NM_030820	NP_110447	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1 precursor	911					cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(2)	2	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			AGACCTGGGTCTCCTGGAGGA	0.498		NA											8	11					0	0	0	0
ECT2L	345930	broad.mit.edu	37	6	139223693	139223693	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr6:139223693G>A	uc003qif.1	+	20	2747	c.2644G>A	c.(2644-2646)GAA>AAA	p.E882K	ECT2L_uc011edq.1_Missense_Mutation_p.E736K	NM_001077706	NP_001071174	Q008S8	ECT2L_HUMAN	epithelial cell transforming sequence 2	882					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity				0						TTGTGCTACAGAAATAGAGGA	0.368		NA											12	37					0	0	0	0
RGS17	26575	broad.mit.edu	37	6	153347672	153347672	+	Silent	SNP	A	A	T			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr6:153347672A>T	uc003qpm.2	-	3	282	c.126T>A	c.(124-126)ACT>ACA	p.T42T		NM_012419	NP_036551	Q9UGC6	RGS17_HUMAN	regulator of G-protein signalling 17	42					negative regulation of signal transduction	cytoplasm|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			pancreas(1)	1		Ovarian(120;0.126)		OV - Ovarian serous cystadenocarcinoma(155;1.09e-09)|BRCA - Breast invasive adenocarcinoma(81;0.0429)		CATTCCTCACAGTGAGGCTGT	0.403		NA							Lung_Cancer_Familial_Clustering_of				26	59					0	0	0	0
ITGB8	3696	broad.mit.edu	37	7	20441678	20441678	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr7:20441678G>T	uc003suu.2	+	10	2321	c.1616G>T	c.(1615-1617)GGA>GTA	p.G539V	ITGB8_uc011jyh.1_Missense_Mutation_p.G404V	NM_002214	NP_002205	P26012	ITB8_HUMAN	integrin, beta 8 precursor	539	Cysteine-rich tandem repeats.|II.|Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|placenta blood vessel development	integrin complex	protein binding|receptor activity			skin(3)	3						ATTAAGCTTGGAAAAGTGTAT	0.388		NA											28	101					5.77e-19	6.92e-19	1	0
PURB	5814	broad.mit.edu	37	7	44924293	44924294	+	Missense_Mutation	DNP	GC	GC	AA			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr7:44924293_44924294GC>AA	uc003tme.2	-	1	667_668	c.654_655GC>TT	c.(652-657)GAGCTC>GATTTC	p.218_219EL>DF		NM_033224	NP_150093	Q96QR8	PURB_HUMAN	purine-rich element binding protein B	218_219	Gly-rich.|By similarity.				regulation of myeloid cell differentiation	DNA replication factor A complex	mRNA binding|single-stranded DNA binding|transcription factor binding				0						CCCTCCGGGAGCTCTCCATACA	0.48		NA											15	50					0	0	0	0
FZD1	8321	broad.mit.edu	37	7	90895177	90895177	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr7:90895177G>C	uc003ula.2	+	1	1395	c.982G>C	c.(982-984)GTG>CTG	p.V328L		NM_003505	NP_003496	Q9UP38	FZD1_HUMAN	frizzled 1 precursor	328	Helical; Name=1; (Potential).				autocrine signaling|axonogenesis|brain development|canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|embryo development|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|lung alveolus development|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to drug|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cell surface|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|receptor binding|Wnt receptor activity|Wnt-protein binding				0	all_cancers(62;3.1e-10)|all_epithelial(64;1.66e-08)|Breast(17;0.000635)|Lung NSC(181;0.153)|all_lung(186;0.154)|all_hematologic(106;0.215)		STAD - Stomach adenocarcinoma(171;0.0134)			CATTTGGTCAGTGCTGTGCTG	0.627		NA											15	87					0	0	0	0
TRRAP	8295	broad.mit.edu	37	7	98535316	98535316	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr7:98535316A>T	uc003upp.2	+	30	4486	c.4277A>T	c.(4276-4278)CAT>CTT	p.H1426L	TRRAP_uc011kis.1_Missense_Mutation_p.H1426L|TRRAP_uc003upr.2_Missense_Mutation_p.H1118L	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	1426					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			ATCCACACACATATGCGACCT	0.413		NA											11	69					0	0	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121636535	121636535	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr7:121636535T>C	uc003vjy.2	+	9	1423	c.1028T>C	c.(1027-1029)ATT>ACT	p.I343T	PTPRZ1_uc003vjz.2_Missense_Mutation_p.I343T	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	343	Extracellular (Potential).|Fibronectin type-III.				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						GATACCATGATTGAGAAGTTT	0.408		NA											4	98					0	0	0	0
RNF133	168433	broad.mit.edu	37	7	122338545	122338545	+	Missense_Mutation	SNP	A	A	C			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr7:122338545A>C	uc003vkj.1	-	1	664	c.428T>G	c.(427-429)TTT>TGT	p.F143C	CADPS2_uc010lkp.2_Intron|CADPS2_uc010lkq.2_Intron	NM_139175	NP_631914	Q8WVZ7	RN133_HUMAN	ring finger protein 133	143	PA.					endoplasmic reticulum membrane|integral to membrane	ligase activity|zinc ion binding			skin(1)	1						TGCCTGATGAAACATGGGGAA	0.423		NA											32	58					0	0	0	0
KLHDC10	23008	broad.mit.edu	37	7	129761910	129761910	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr7:129761910A>G	uc003vpj.1	+	5	782	c.647A>G	c.(646-648)AAT>AGT	p.N216S	KLHDC10_uc003vpk.1_Missense_Mutation_p.N187S|KLHDC10_uc010lmb.1_Missense_Mutation_p.N113S	NM_014997	NP_055812	Q6PID8	KLD10_HUMAN	kelch domain containing 10	216	Kelch 2.										0						GCCATCATCAATGGCTCCCTT	0.418		NA											7	32					0	0	0	0
AKR1B1	231	broad.mit.edu	37	7	134135632	134135632	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr7:134135632T>C	uc003vrp.1	-	3	331	c.257A>G	c.(256-258)AAG>AGG	p.K86R	AKR1B1_uc003vrq.1_RNA	NM_001628	NP_001619	P15121	ALDR_HUMAN	aldo-keto reductase family 1, member B1	86					C21-steroid hormone biosynthetic process|carbohydrate metabolic process|response to stress	cytosol|extracellular space|nucleus	alditol:NADP+ 1-oxidoreductase activity|electron carrier activity|protein binding	p.K86K(1)		ovary(3)	3					NADH(DB00157)|Sulindac(DB00605)	CACCAGGCCCTTCTCATGGTA	0.557		NA											5	26					0	0	0	0
MLL3	58508	broad.mit.edu	37	7	151874913	151874913	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr7:151874913G>A	uc003wla.2	-	38	7844	c.7625C>T	c.(7624-7626)TCA>TTA	p.S2542L	MLL3_uc003wkz.2_Missense_Mutation_p.S1603L|MLL3_uc003wky.2_Missense_Mutation_p.S51L	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	2542	Pro-rich.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		GCTCTGTGGTGAAAAATGCTG	0.453		NA	N		medulloblastoma								40	71					0	0	0	0
HTR5A	3361	broad.mit.edu	37	7	154863070	154863070	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr7:154863070G>A	uc003wlu.1	+	1	525	c.461G>A	c.(460-462)CGC>CAC	p.R154H	uc011kvt.1_5'UTR|uc003wlt.2_5'UTR	NM_024012	NP_076917	P47898	5HT5A_HUMAN	5-hydroxytryptamine receptor 5A	154	Cytoplasmic (By similarity).					integral to plasma membrane	serotonin receptor activity			ovary(2)|large_intestine(1)	3	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0238)	UCEC - Uterine corpus endometrioid carcinoma (81;0.171)		CTCCGCACCCGCAAGTGCGTC	0.617		NA											9	25					0	0	0	0
CSMD1	64478	broad.mit.edu	37	8	3087643	3087643	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr8:3087643G>A	uc011kwk.1	-	27	4657	c.4267C>T	c.(4267-4269)CAG>TAG	p.Q1423*	CSMD1_uc011kwj.1_Nonsense_Mutation_p.Q815*|CSMD1_uc003wqe.2_Nonsense_Mutation_p.Q579*	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	1423	Extracellular (Potential).|Sushi 8.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CCTTGGAGCTGATAGCCAGGG	0.517		NA											10	16					0	0	0	0
ZFPM2	23414	broad.mit.edu	37	8	106814630	106814630	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr8:106814630C>T	uc003ymd.2	+	8	2343	c.2320C>T	c.(2320-2322)CAA>TAA	p.Q774*	ZFPM2_uc011lhs.1_Nonsense_Mutation_p.Q505*	NM_012082	NP_036214	Q8WW38	FOG2_HUMAN	zinc finger protein, multitype 2	774					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			ovary(4)|large_intestine(1)	5			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			TACCTCCACTCAAGAACCCAC	0.463		NA											4	27					0	0	0	0
LY6H	4062	broad.mit.edu	37	8	144239772	144239772	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr8:144239772C>G	uc011lka.1	-	4	484	c.318G>C	c.(316-318)GAG>GAC	p.E106D	LY6H_uc011lkb.1_Missense_Mutation_p.E127D|LY6H_uc003yxt.2_Missense_Mutation_p.E144D|LY6H_uc011lkc.1_Missense_Mutation_p.E127D	NM_002347	NP_002338	O94772	LY6H_HUMAN	lymphocyte antigen 6 complex, locus H isoform a	106					nervous system development|organ morphogenesis	anchored to membrane|plasma membrane					0	all_cancers(97;6.49e-11)|all_epithelial(106;2.77e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					ACAAATCCTTCTCGCAGCAGT	0.612		NA											5	49					0	0	0	0
KIAA1432	57589	broad.mit.edu	37	9	5773076	5773076	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr9:5773076G>C	uc003zji.2	+	24	3835	c.3742G>C	c.(3742-3744)GAC>CAC	p.D1248H	KIAA1432_uc003zjl.3_Missense_Mutation_p.D1211H|ERMP1_uc011lme.1_Intron	NM_020829	NP_065880	Q4ADV7	RIC1_HUMAN	connexin 43-interacting protein 150 isoform a	1327						integral to membrane					0		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		GGCCTCTACAGACTGGTAAGT	0.443		NA											6	25					0	0	0	0
VCP	7415	broad.mit.edu	37	9	35059698	35059698	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr9:35059698C>T	uc003zvy.2	-	14	2185	c.1796G>A	c.(1795-1797)CGA>CAA	p.R599Q	VCP_uc003zvz.2_RNA|VCP_uc010mkh.1_Missense_Mutation_p.R268Q|VCP_uc010mki.1_Missense_Mutation_p.R554Q	NM_007126	NP_009057	P55072	TERA_HUMAN	valosin-containing protein	599					activation of caspase activity|double-strand break repair|endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|retrograde protein transport, ER to cytosol	cytosol|endoplasmic reticulum|microsome|nucleus|proteasome complex	ATP binding|ATPase activity|lipid binding|polyubiquitin binding|protein domain specific binding|protein phosphatase binding			upper_aerodigestive_tract(1)	1			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			GTTGATGACTCGGTCAGCAGC	0.522		NA											18	87					0	0	0	0
VCP	7415	broad.mit.edu	37	9	35061650	35061650	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr9:35061650T>A	uc003zvy.2	-	10	1507	c.1118A>T	c.(1117-1119)GAT>GTT	p.D373V	VCP_uc003zvz.2_RNA|VCP_uc010mkh.1_Missense_Mutation_p.D42V|VCP_uc010mki.1_Missense_Mutation_p.D328V	NM_007126	NP_009057	P55072	TERA_HUMAN	valosin-containing protein	373					activation of caspase activity|double-strand break repair|endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|retrograde protein transport, ER to cytosol	cytosol|endoplasmic reticulum|microsome|nucleus|proteasome complex	ATP binding|ATPase activity|lipid binding|polyubiquitin binding|protein domain specific binding|protein phosphatase binding			upper_aerodigestive_tract(1)	1			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			TCCTGTAGCATCAGGAATTCC	0.478		NA											11	187					0	0	0	0
SHB	6461	broad.mit.edu	37	9	37948721	37948721	+	Silent	SNP	G	G	A			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr9:37948721G>A	uc004aax.2	-	5	1825	c.1257C>T	c.(1255-1257)GAC>GAT	p.D419D		NM_003028	NP_003019	Q15464	SHB_HUMAN	Src homology 2 domain containing adaptor protein	419	SH2.				angiogenesis|apoptosis|cell differentiation|signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity			central_nervous_system(2)|skin(1)	3		all_epithelial(88;0.122)		GBM - Glioblastoma multiforme(29;3.27e-05)|Lung(182;0.0658)		GGTTCTCGGCGTCTCCTCTGC	0.607		NA											7	107					0	0	0	0
ZNF367	195828	broad.mit.edu	37	9	99150720	99150720	+	Silent	SNP	C	C	T			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr9:99150720C>T	uc004awf.2	-	5	1207	c.852G>A	c.(850-852)CAG>CAA	p.Q284Q		NM_153695	NP_710162	Q7RTV3	ZN367_HUMAN	zinc finger protein 367	284					regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Acute lymphoblastic leukemia(62;0.0167)				TGGGGGTGCGCTGCTCTCTCA	0.438		NA											24	41					0	0	0	0
COQ4	51117	broad.mit.edu	37	9	131088088	131088088	+	Silent	SNP	C	C	G			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr9:131088088C>G	uc004bur.3	+	4	677	c.330C>G	c.(328-330)CTC>CTG	p.L110L	COQ4_uc011max.1_Silent_p.L110L|COQ4_uc004bus.2_Silent_p.L86L|COQ4_uc010mxy.2_Silent_p.L86L	NM_016035	NP_057119	Q9Y3A0	COQ4_HUMAN	coenzyme Q4 homolog precursor	110					ubiquinone biosynthetic process	mitochondrial inner membrane					0						CATCCACCCTCGACCTGGGCA	0.582		NA											13	31					0	0	0	0
MAGEB6	158809	broad.mit.edu	37	X	26212225	26212225	+	Missense_Mutation	SNP	G	G	T	rs140212002		TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chrX:26212225G>T	uc004dbr.2	+	2	411	c.262G>T	c.(262-264)GGC>TGC	p.G88C	MAGEB6_uc010ngc.1_5'UTR	NM_173523	NP_775794	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	88	Ser-rich.									ovary(3)	3						GGCTGCCAACGGCCAAGATGA	0.542		NA											10	18					2.81e-09	3.26e-09	1	0
MAGEB1	4112	broad.mit.edu	37	X	30268842	30268842	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chrX:30268842G>T	uc004dcc.2	+	4	552	c.232G>T	c.(232-234)GAA>TAA	p.E78*	MAGEB1_uc004dcd.2_Nonsense_Mutation_p.E78*|MAGEB1_uc004dce.2_Nonsense_Mutation_p.E78*	NM_002363	NP_002354	P43366	MAGB1_HUMAN	melanoma antigen family B, 1	78											0						GTCATGTACCGAATCTGACGA	0.552		NA											5	8					1.24e-05	1.34e-05	1	0
DMD	1756	broad.mit.edu	37	X	31497125	31497125	+	Silent	SNP	T	T	C			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chrX:31497125T>C	uc004dda.1	-	58	8887	c.8643A>G	c.(8641-8643)CTA>CTG	p.L2881L	DMD_uc004dcq.1_Silent_p.L152L|DMD_uc004dcr.1_Silent_p.L421L|DMD_uc004dcs.1_Silent_p.L421L|DMD_uc004dct.1_Silent_p.L421L|DMD_uc004dcu.1_Silent_p.L421L|DMD_uc004dcv.1_Silent_p.L421L|DMD_uc004dcw.2_Silent_p.L1537L|DMD_uc004dcx.2_Silent_p.L1540L|DMD_uc004dcz.2_Silent_p.L2758L|DMD_uc004dcy.1_Silent_p.L2877L|DMD_uc004ddb.1_Silent_p.L2873L	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	2881	Spectrin 20.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				AGAGTTTCTCTAGTCCTTCCA	0.428		NA											14	9					0	0	0	0
SMC1A	8243	broad.mit.edu	37	X	53421731	53421731	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chrX:53421731C>G	uc004dsg.2	-	19	3009	c.2940G>C	c.(2938-2940)GAG>GAC	p.E980D	SMC1A_uc011moe.1_Missense_Mutation_p.E958D	NM_006306	NP_006297	Q14683	SMC1A_HUMAN	structural maintenance of chromosomes 1A	980					cell cycle checkpoint|cell division|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic sister chromatid cohesion|mitotic spindle organization|negative regulation of DNA endoreduplication|nuclear mRNA splicing, via spliceosome|response to radiation|signal transduction in response to DNA damage	cohesin core heterodimer|condensed chromosome kinetochore|condensed nuclear chromosome|cytoplasm|meiotic cohesin complex|nucleoplasm	ATP binding|chromatin binding|microtubule motor activity|protein heterodimerization activity			ovary(5)|central_nervous_system(1)	6						CGTAGTCAATCTCAATGAGGG	0.542		NA											4	26					0	0	0	0
XKRX	402415	broad.mit.edu	37	X	100169656	100169656	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chrX:100169656C>A	uc004egn.2	-	3	1626	c.1021G>T	c.(1021-1023)GAC>TAC	p.D341Y	XKRX_uc011mre.1_Missense_Mutation_p.D137Y	NM_212559	NP_997724	Q6PP77	XKR2_HUMAN	XK, Kell blood group complex subunit-related,	341						integral to membrane|plasma membrane				breast(1)	1						TGCCCTTTGTCGACGAGATCT	0.478		NA											60	66					5.09e-23	6.15e-23	1	0
BCORL1	63035	broad.mit.edu	37	X	129147536	129147536	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chrX:129147536C>T	uc004evb.1	+	4	902	c.788C>T	c.(787-789)CCG>CTG	p.P263L	BCORL1_uc010nrd.1_Missense_Mutation_p.P165L	NM_021946	NP_068765	Q5H9F3	BCORL_HUMAN	BCL6 co-repressor-like 1	263	Pro-rich.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(4)|breast(2)|lung(1)	7						CCAGCGCCACCGTCAGTGCCC	0.627		NA											16	49					0	0	0	0
SLITRK4	139065	broad.mit.edu	37	X	142718314	142718314	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chrX:142718314C>T	uc004fbx.2	-	2	987	c.611G>A	c.(610-612)CGT>CAT	p.R204H	SLITRK4_uc004fby.2_Missense_Mutation_p.R204H	NM_173078	NP_775101	Q8IW52	SLIK4_HUMAN	slit and trk like 4 protein precursor	204	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|large_intestine(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					TTCAACGACACGGCCAATGTG	0.428		NA											25	54					0	0	0	0
PASD1	139135	broad.mit.edu	37	X	150817138	150817138	+	Missense_Mutation	SNP	A	A	C			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chrX:150817138A>C	uc004fev.3	+	9	1013	c.681A>C	c.(679-681)GAA>GAC	p.E227D		NM_173493	NP_775764	Q8IV76	PASD1_HUMAN	PAS domain containing 1	227						nucleus	signal transducer activity			ovary(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					TGTACGTTGAACCCgctgctg	0.353		NA											10	74					0	0	0	0
TAZ	6901	broad.mit.edu	37	X	153649016	153649016	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chrX:153649016G>A	uc004fkx.2	+	10	1023	c.719G>A	c.(718-720)GGG>GAG	p.G240E	TAZ_uc004fky.2_Missense_Mutation_p.G226E|TAZ_uc004fkz.2_RNA|TAZ_uc004fla.2_Missense_Mutation_p.G210E|TAZ_uc004flb.2_Missense_Mutation_p.G196E|TAZ_uc010nuy.2_Missense_Mutation_p.G244E|TAZ_uc004flc.3_Missense_Mutation_p.G210E	NM_000116	NP_000107	Q16635	TAZ_HUMAN	tafazzin isoform 1	240					cardiac muscle contraction|cardiac muscle tissue development|cardiolipin biosynthetic process|cristae formation|hemopoiesis|mitochondrial ATP synthesis coupled electron transport|mitochondrial respiratory chain complex I assembly|skeletal muscle tissue development	integral to membrane|mitochondrion	1-acylglycerophosphocholine O-acyltransferase activity				0	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GTGCTGATCGGGAAGCCCTTC	0.642		NA											18	19					0	0	0	0
F8	2157	broad.mit.edu	37	X	154221234	154221234	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chrX:154221234C>G	uc004fmt.2	-	4	749	c.578G>C	c.(577-579)GGA>GCA	p.G193A	F8_uc011mzx.1_Missense_Mutation_p.G158A	NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	193	Plastocyanin-like 1.|F5/8 type A 1.		G -> R (in HEMA; severe familial).		acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	TAGTAGGGCTCCAATGAGGCC	0.413		NA											3	79					0	0	0	0
BMS1	9790	broad.mit.edu	37	10	43312844	43312846	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr10:43312844_43312846delAAG	uc001jaj.2	+	15	2840_2842	c.2482_2484delAAG	c.(2482-2484)AAGdel	p.K829del		NM_014753	NP_055568	Q14692	BMS1_HUMAN	BMS1-like, ribosome assembly protein	829					ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			ovary(2)|upper_aerodigestive_tract(1)	3						GCATTTGGATAAGAAGAGAAAAT	0.34		NA											7	60	---	---	---	---	NA	NA	NA	NA
TMEM134	80194	broad.mit.edu	37	11	67232544	67232544	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr11:67232544delT	uc001olq.1	-	5	502	c.434delA	c.(433-435)GAGfs	p.E145fs	TMEM134_uc001olp.1_Frame_Shift_Del_p.E136fs|TMEM134_uc001olr.1_Intron|TMEM134_uc001ols.1_RNA|TMEM134_uc001olt.1_RNA	NM_025124	NP_079400	Q9H6X4	TM134_HUMAN	transmembrane protein 134 isoform a	145	Extracellular (Potential).					integral to membrane					0						GGGGGTCGCCTCCAGTCCCAC	0.577		NA											2	4	---	---	---	---	NA	NA	NA	NA
ZNF821	55565	broad.mit.edu	37	16	71894083	71894088	+	In_Frame_Del	DEL	CATTTT	CATTTT	-			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr16:71894083_71894088delCATTTT	uc010vmj.1	-	7	1448_1453	c.1072_1077delAAAATG	c.(1072-1077)AAAATGdel	p.KM358del	ATXN1L_uc010vmi.1_Intron|ZNF821_uc002fbe.2_In_Frame_Del_p.KM208del|ZNF821_uc002fbf.2_In_Frame_Del_p.KM316del|ZNF821_uc002fbg.3_In_Frame_Del_p.KM208del|ZNF821_uc002fbh.3_In_Frame_Del_p.KM316del|ZNF821_uc002fbi.3_In_Frame_Del_p.KM155del	NM_017530	NP_060000	O75541	ZN821_HUMAN	zinc finger protein 821	358_359	Potential.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						ACATCATGTCCATTTTCTCCAGCCTC	0.587		NA											8	55	---	---	---	---	NA	NA	NA	NA
NFKBIB	4793	broad.mit.edu	37	19	39399378	39399380	+	In_Frame_Del	DEL	ACG	ACG	-	rs141886159		TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr19:39399378_39399380delACG	uc002ojw.2	+	6	1035_1037	c.977_979delACG	c.(976-981)TACGAC>TAC	p.D328del	NFKBIB_uc002ojx.2_3'UTR|NFKBIB_uc002ojy.2_3'UTR	NM_002503	NP_002494	Q15653	IKBB_HUMAN	nuclear factor of kappa light polypeptide gene	328					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription, DNA-dependent	cytosol|nucleus	protein binding|signal transducer activity|transcription coactivator activity			lung(1)|kidney(1)	2	all_cancers(60;4.39e-06)|Ovarian(47;0.0454)		Lung(45;0.000419)|LUSC - Lung squamous cell carcinoma(53;0.000554)			CAGGATGAATACGACGACATTGT	0.596		NA											19	65	---	---	---	---	NA	NA	NA	NA
TTN	7273	broad.mit.edu	37	2	179459274	179459275	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr2:179459274_179459275insT	uc010zfg.1	-	245	50466_50467	c.50242_50243insA	c.(50242-50244)ATTfs	p.I16748fs	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Frame_Shift_Ins_p.I10443fs|TTN_uc010zfi.1_Frame_Shift_Ins_p.I10376fs|TTN_uc010zfj.1_Frame_Shift_Ins_p.I10251fs	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	17675							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATAGTTAATAATTTCTGACCCA	0.391		NA											41	59	---	---	---	---	NA	NA	NA	NA
BCLAF1	9774	broad.mit.edu	37	6	136582553	136582553	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CN-6023-01A-11D-1683-08	TCGA-CN-6023-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d03b8f96-c932-4abf-b508-f4e1b50739ee	d5b021c2-0f46-4f80-b693-57047c559add	g.chr6:136582553delA	uc003qgx.1	-	12	2860	c.2607delT	c.(2605-2607)TTTfs	p.F869fs	BCLAF1_uc011edb.1_Frame_Shift_Del_p.F148fs|BCLAF1_uc003qgw.1_Frame_Shift_Del_p.F696fs|BCLAF1_uc003qgy.1_Frame_Shift_Del_p.F818fs|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Frame_Shift_Del_p.F867fs	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	869					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		TGCCACGTTGAAAAGTACCAC	0.413		NA											18	256	---	---	---	---	NA	NA	NA	NA