Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
EML3	256364	broad.mit.edu	37	11	62373575	62373575	+	Missense_Mutation	SNP	A	A	C			TCGA-CN-6017-01A-11D-1683-08	TCGA-CN-6017-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7cd89cbe-6bd9-41a2-a042-345fa0a09866	df3b1467-ca2e-4e97-992d-6ab6a4aea441	g.chr11:62373575A>C	uc001ntu.1	-	13	1924	c.1616T>G	c.(1615-1617)GTA>GGA	p.V539G	EML3_uc001ntr.1_Missense_Mutation_p.V511G|EML3_uc001nts.1_Missense_Mutation_p.V511G|EML3_uc001ntt.1_Missense_Mutation_p.V423G|EML3_uc010rly.1_Missense_Mutation_p.V539G|EML3_uc009yny.1_Missense_Mutation_p.V322G	NM_153265	NP_694997	Q32P44	EMAL3_HUMAN	echinoderm microtubule associated protein like	539	WD 5.					cytoplasm|microtubule	protein binding			ovary(1)	1						CCCCCACTGTACCAGCCGGCG	0.647		NA											12	70					0	0	0	0
NEDD1	121441	broad.mit.edu	37	12	97331069	97331069	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6017-01A-11D-1683-08	TCGA-CN-6017-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7cd89cbe-6bd9-41a2-a042-345fa0a09866	df3b1467-ca2e-4e97-992d-6ab6a4aea441	g.chr12:97331069G>A	uc001teu.3	+	9	1354	c.1015G>A	c.(1015-1017)GGA>AGA	p.G339R	NEDD1_uc001tev.3_Missense_Mutation_p.G339R|NEDD1_uc010svc.1_Missense_Mutation_p.G250R|NEDD1_uc001tew.2_Missense_Mutation_p.G346R|NEDD1_uc001tex.2_Missense_Mutation_p.G250R	NM_152905	NP_690869	Q8NHV4	NEDD1_HUMAN	neural precursor cell expressed, developmentally	339					cell division|G2/M transition of mitotic cell cycle|mitosis	cytosol					0						TCAGAATTCCGGAATTGTCAG	0.428		NA											4	64					0	0	0	0
SMG1	23049	broad.mit.edu	37	16	18846419	18846419	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-6017-01A-11D-1683-08	TCGA-CN-6017-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7cd89cbe-6bd9-41a2-a042-345fa0a09866	df3b1467-ca2e-4e97-992d-6ab6a4aea441	g.chr16:18846419T>G	uc002dfm.2	-	49	8488	c.8125A>C	c.(8125-8127)ACC>CCC	p.T2709P	SMG1_uc010bwb.2_Missense_Mutation_p.T2569P|SMG1_uc010bwa.2_Missense_Mutation_p.T1440P	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	2709					DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16						CGCTGCAGGGTCATTTCAGTG	0.443		NA											4	121					0	0	0	0
POTEC	388468	broad.mit.edu	37	18	14513764	14513764	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6017-01A-11D-1683-08	TCGA-CN-6017-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7cd89cbe-6bd9-41a2-a042-345fa0a09866	df3b1467-ca2e-4e97-992d-6ab6a4aea441	g.chr18:14513764C>T	uc010dln.2	-	10	1884	c.1430G>A	c.(1429-1431)CGG>CAG	p.R477Q	POTEC_uc010xaj.1_RNA	NM_001137671	NP_001131143	B2RU33	POTEC_HUMAN	ANKRD26-like family B, member 2	477										skin(3)	3						AAGTTGTTTCCGGGTATCATT	0.358		NA											3	30					0	0	0	0
OR7G2	390882	broad.mit.edu	37	19	9213904	9213904	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6017-01A-11D-1683-08	TCGA-CN-6017-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7cd89cbe-6bd9-41a2-a042-345fa0a09866	df3b1467-ca2e-4e97-992d-6ab6a4aea441	g.chr19:9213904G>T	uc010xkk.1	-	1	79	c.79C>A	c.(79-81)CAA>AAA	p.Q27K		NM_001005193	NP_001005193	Q8NG99	OR7G2_HUMAN	olfactory receptor, family 7, subfamily G,	6	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						ATAGCTGTTTGGTTTCTCGCT	0.358		NA											3	59					6.4e-05	6.98e-05	1	0
TRPM4	54795	broad.mit.edu	37	19	49705272	49705272	+	Missense_Mutation	SNP	A	A	C			TCGA-CN-6017-01A-11D-1683-08	TCGA-CN-6017-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7cd89cbe-6bd9-41a2-a042-345fa0a09866	df3b1467-ca2e-4e97-992d-6ab6a4aea441	g.chr19:49705272A>C	uc002pmw.2	+	20	3077	c.3005A>C	c.(3004-3006)CAC>CCC	p.H1002P	TRPM4_uc010emu.2_Missense_Mutation_p.H857P|TRPM4_uc010yak.1_Missense_Mutation_p.H466P|TRPM4_uc002pmx.2_Missense_Mutation_p.H828P|TRPM4_uc010emv.2_Missense_Mutation_p.H887P|TRPM4_uc010yal.1_Missense_Mutation_p.H648P|TRPM4_uc002pmy.2_Missense_Mutation_p.H344P	NM_017636	NP_060106	Q8TD43	TRPM4_HUMAN	transient receptor potential cation channel,	1002	Extracellular (Potential).				dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding			ovary(1)|central_nervous_system(1)	2		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)		TTCTGGGCACACCCTCCTGGG	0.627		NA											7	86					0	0	0	0
NCKAP1	10787	broad.mit.edu	37	2	183888621	183888621	+	Silent	SNP	T	T	C			TCGA-CN-6017-01A-11D-1683-08	TCGA-CN-6017-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7cd89cbe-6bd9-41a2-a042-345fa0a09866	df3b1467-ca2e-4e97-992d-6ab6a4aea441	g.chr2:183888621T>C	uc002upc.2	-	2	534	c.132A>G	c.(130-132)AAA>AAG	p.K44K	NCKAP1_uc002upb.2_Silent_p.K50K	NM_013436	NP_038464	Q9Y2A7	NCKP1_HUMAN	NCK-associated protein 1 isoform 1	44					apoptosis|central nervous system development	integral to membrane|lamellipodium membrane	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			GATAGGATGGTTTTGCCTTGG	0.353		NA											5	109					0	0	0	0
SLC15A2	6565	broad.mit.edu	37	3	121647850	121647850	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6017-01A-11D-1683-08	TCGA-CN-6017-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7cd89cbe-6bd9-41a2-a042-345fa0a09866	df3b1467-ca2e-4e97-992d-6ab6a4aea441	g.chr3:121647850C>G	uc003eep.2	+	16	1516	c.1363C>G	c.(1363-1365)CTG>GTG	p.L455V	SLC15A2_uc011bjn.1_Missense_Mutation_p.L424V	NM_021082	NP_066568	Q16348	S15A2_HUMAN	peptide transporter 2 isoform a	455					protein transport	integral to plasma membrane	peptide:hydrogen symporter activity|protein binding			skin(1)	1				GBM - Glioblastoma multiforme(114;0.0967)	Cefadroxil(DB01140)	CTATTCCAAACTGCACCTGAA	0.403		NA											4	106					0	0	0	0
DOCK2	1794	broad.mit.edu	37	5	169122871	169122871	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6017-01A-11D-1683-08	TCGA-CN-6017-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7cd89cbe-6bd9-41a2-a042-345fa0a09866	df3b1467-ca2e-4e97-992d-6ab6a4aea441	g.chr5:169122871G>A	uc003maf.2	+	10	988	c.908G>A	c.(907-909)GGC>GAC	p.G303D	DOCK2_uc011der.1_RNA	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	303					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GTCCGGGTCGGCAAGATGGAT	0.463		NA											4	59					0	0	0	0
OR12D2	26529	broad.mit.edu	37	6	29365004	29365004	+	Silent	SNP	C	C	G			TCGA-CN-6017-01A-11D-1683-08	TCGA-CN-6017-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7cd89cbe-6bd9-41a2-a042-345fa0a09866	df3b1467-ca2e-4e97-992d-6ab6a4aea441	g.chr6:29365004C>G	uc003nmf.3	+	1	589	c.528C>G	c.(526-528)CTC>CTG	p.L176L		NM_013936	NP_039224	P58182	O12D2_HUMAN	olfactory receptor, family 12, subfamily D,	176	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						ATCATTTTCTCTGTGATATTA	0.483		NA											5	114					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7579441	7579453	+	Frame_Shift_Del	DEL	CGGTGTAGGAGCT	CGGTGTAGGAGCT	-			TCGA-CN-6017-01A-11D-1683-08	TCGA-CN-6017-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7cd89cbe-6bd9-41a2-a042-345fa0a09866	df3b1467-ca2e-4e97-992d-6ab6a4aea441	g.chr17:7579441_7579453delCGGTGTAGGAGCT	uc002gim.2	-	4	428_440	c.234_246delAGCTCCTACACCG	c.(232-246)GCAGCTCCTACACCGfs	p.A78fs	TP53_uc002gig.1_Frame_Shift_Del_p.A78fs|TP53_uc002gih.2_Frame_Shift_Del_p.A78fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Frame_Shift_Del_p.A78fs|TP53_uc010cni.1_Frame_Shift_Del_p.A78fs|TP53_uc002gij.2_Frame_Shift_Del_p.A78fs|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Frame_Shift_Del_p.A39fs|TP53_uc010cnk.1_Frame_Shift_Del_p.A93fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	78_82	Interaction with WWOX.|Interaction with HRMT1L2.		P -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|P -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.P82L(5)|p.A76_S90del15(3)|p.G59fs*23(3)|p.T81I(2)|p.A78V(2)|p.V73fs*9(1)|p.R65fs*38(1)|p.D48fs*55(1)|p.P80L(1)|p.A79V(1)|p.A79_A88del10(1)|p.P82fs*43(1)|p.P13fs*18(1)|p.S33fs*23(1)|p.P82fs*67(1)|p.P80fs*41(1)|p.P82P(1)|p.P80fs*43(1)|p.A83fs*91(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CAGGGGCCGCCGGTGTAGGAGCTGCTGGTGCAG	0.61		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			7	98	---	---	---	---	NA	NA	NA	NA