Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
AGRN	375790	broad.mit.edu	37	1	981868	981868	+	Silent	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:981868C>T	uc001ack.1	+	18	3053	c.3003C>T	c.(3001-3003)CCC>CCT	p.P1001P		NM_198576	NP_940978	O00468	AGRIN_HUMAN	agrin precursor	1001	Ser/Thr-rich.				axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			central_nervous_system(2)|breast(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		CGGCCCCCCCCGGCGCCCTCC	0.701		NA											4	26					0	0	0	0
NBPF1	55672	broad.mit.edu	37	1	16893778	16893778	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:16893778G>A	uc009vos.1	-	26	3848	c.2960C>T	c.(2959-2961)TCG>TTG	p.S987L	NBPF1_uc009vot.1_Missense_Mutation_p.S370L|NBPF1_uc001ayz.1_Missense_Mutation_p.S370L|NBPF1_uc010oce.1_Missense_Mutation_p.S641L	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672	987	NBPF 6.					cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TGAAGGAGTTGAATAACATCT	0.483		NA											13	791					0	0	0	0
UBR4	23352	broad.mit.edu	37	1	19473443	19473443	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:19473443C>T	uc001bbi.2	-	52	7685	c.7681G>A	c.(7681-7683)GAG>AAG	p.E2561K	UBR4_uc001bbk.1_Missense_Mutation_p.E215K	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	2561					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		TCCTTGCCCTCTTTGCTAGAT	0.527		NA											57	175					0	0	0	0
RPS6KA1	6195	broad.mit.edu	37	1	26898704	26898704	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:26898704G>A	uc001bmr.1	+	20	2030	c.1867G>A	c.(1867-1869)GAG>AAG	p.E623K	RPS6KA1_uc010ofe.1_Missense_Mutation_p.E531K|RPS6KA1_uc010off.1_3'UTR|RPS6KA1_uc001bms.1_Missense_Mutation_p.E632K|RPS6KA1_uc009vsl.1_Missense_Mutation_p.E466K	NM_002953	NP_002944	Q15418	KS6A1_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	623	Protein kinase 2.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein binding|protein serine/threonine kinase activity			lung(1)	1		all_cancers(24;2.49e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00571)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;1.12e-50)|OV - Ovarian serous cystadenocarcinoma(117;2.89e-29)|Colorectal(126;1.4e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000537)|KIRC - Kidney renal clear cell carcinoma(1967;0.000759)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0361)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.161)|LUSC - Lung squamous cell carcinoma(448;0.234)		TGACACACCAGAGGAAATCCT	0.567		NA											10	55					0	0	0	0
GPATCH3	63906	broad.mit.edu	37	1	27220788	27220788	+	Silent	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:27220788C>T	uc001bne.2	-	3	1019	c.990G>A	c.(988-990)GAG>GAA	p.E330E	GPATCH3_uc009vsp.1_Silent_p.E141E	NM_022078	NP_071361	Q96I76	GPTC3_HUMAN	G patch domain containing 3	330	Glu-rich.					intracellular	nucleic acid binding				0		all_cancers(24;1.29e-21)|all_epithelial(13;2.35e-19)|Colorectal(325;0.000147)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Breast(348;0.00131)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;3.97e-51)|OV - Ovarian serous cystadenocarcinoma(117;9.55e-30)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|STAD - Stomach adenocarcinoma(196;0.000595)|KIRC - Kidney renal clear cell carcinoma(1967;0.00072)|READ - Rectum adenocarcinoma(331;0.0419)		AGCCACCCTTCTCCCACTTGA	0.582		NA											41	95					0	0	0	0
GPATCH3	63906	broad.mit.edu	37	1	27223839	27223839	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:27223839C>G	uc001bne.2	-	2	858	c.829G>C	c.(829-831)GAG>CAG	p.E277Q	GPATCH3_uc009vsp.1_Missense_Mutation_p.E88Q	NM_022078	NP_071361	Q96I76	GPTC3_HUMAN	G patch domain containing 3	277	Glu-rich.					intracellular	nucleic acid binding				0		all_cancers(24;1.29e-21)|all_epithelial(13;2.35e-19)|Colorectal(325;0.000147)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Breast(348;0.00131)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;3.97e-51)|OV - Ovarian serous cystadenocarcinoma(117;9.55e-30)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|STAD - Stomach adenocarcinoma(196;0.000595)|KIRC - Kidney renal clear cell carcinoma(1967;0.00072)|READ - Rectum adenocarcinoma(331;0.0419)		ACTTCTTCCTCAGGCTCTCCA	0.542		NA											48	118					0	0	0	0
EYA3	2140	broad.mit.edu	37	1	28374933	28374933	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:28374933T>C	uc001bpi.1	-	3	203	c.38A>G	c.(37-39)AAA>AGA	p.K13R	EYA3_uc010ofs.1_5'UTR|EYA3_uc010oft.1_Missense_Mutation_p.K13R|EYA3_uc001bpj.2_Missense_Mutation_p.K13R|EYA3_uc001bpk.1_RNA|EYA3_uc010ofu.1_RNA	NM_001990	NP_001981	Q99504	EYA3_HUMAN	eyes absent 3	13					anatomical structure morphogenesis|double-strand break repair|histone dephosphorylation|multicellular organismal development|positive regulation of DNA repair|regulation of transcription, DNA-dependent|response to ionizing radiation|transcription, DNA-dependent|visual perception	cytoplasm	metal ion binding|protein binding|protein tyrosine phosphatase activity			ovary(2)|skin(1)	3		Colorectal(325;3.46e-05)|all_lung(284;0.000414)|Lung NSC(340;0.000432)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0484)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;2.8e-06)|STAD - Stomach adenocarcinoma(196;0.00364)|KIRC - Kidney renal clear cell carcinoma(1967;0.00378)|BRCA - Breast invasive adenocarcinoma(304;0.00718)|READ - Rectum adenocarcinoma(331;0.0642)		CTTGGCTTTTTTCACCTGCAA	0.289		NA											8	25					0	0	0	0
ZMYM1	79830	broad.mit.edu	37	1	35579545	35579545	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:35579545G>C	uc001bym.2	+	11	2262	c.2114G>C	c.(2113-2115)GGA>GCA	p.G705A	ZMYM1_uc001byn.2_Missense_Mutation_p.G705A|ZMYM1_uc010ohu.1_Missense_Mutation_p.G686A|ZMYM1_uc001byo.2_Missense_Mutation_p.G345A|ZMYM1_uc009vut.2_Missense_Mutation_p.G630A	NM_024772	NP_079048	Q5SVZ6	ZMYM1_HUMAN	zinc finger, MYM domain containing 1	705						nucleus	nucleic acid binding|protein dimerization activity|zinc ion binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				CAGCAAATTGGAGTTGATATG	0.353		NA											8	43					0	0	0	0
ZMYM1	79830	broad.mit.edu	37	1	35579633	35579633	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:35579633G>C	uc001bym.2	+	11	2350	c.2202G>C	c.(2200-2202)AAG>AAC	p.K734N	ZMYM1_uc001byn.2_Missense_Mutation_p.K734N|ZMYM1_uc010ohu.1_Missense_Mutation_p.K715N|ZMYM1_uc001byo.2_Missense_Mutation_p.K374N|ZMYM1_uc009vut.2_Missense_Mutation_p.K659N	NM_024772	NP_079048	Q5SVZ6	ZMYM1_HUMAN	zinc finger, MYM domain containing 1	734						nucleus	nucleic acid binding|protein dimerization activity|zinc ion binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				CAGAATTCAAGAAAGAAGAAC	0.323		NA											12	47					0	0	0	0
MFSD2A	84879	broad.mit.edu	37	1	40434278	40434278	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:40434278G>A	uc001cev.2	+	13	1610	c.1429G>A	c.(1429-1431)GAA>AAA	p.E477K	MFSD2A_uc010ojb.1_Missense_Mutation_p.E425K|MFSD2A_uc001ceu.2_Missense_Mutation_p.E464K|MFSD2A_uc010ojc.1_Missense_Mutation_p.E308K|MFSD2A_uc009vvy.2_RNA|MFSD2A_uc001cex.2_Missense_Mutation_p.E128K	NM_001136493	NP_001129965	Q8NA29	MFS2A_HUMAN	major facilitator superfamily domain containing	477					transmembrane transport	endoplasmic reticulum membrane|integral to membrane				ovary(1)|pancreas(1)	2						CTCGCAGCCGGAACGTGTCAA	0.587		NA											45	84					0	0	0	0
HIVEP3	59269	broad.mit.edu	37	1	41976647	41976647	+	Silent	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:41976647C>G	uc001cgz.3	-	9	7909	c.6696G>C	c.(6694-6696)CTG>CTC	p.L2232L	HIVEP3_uc001cha.3_Silent_p.L2231L|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	2232					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				GGGCCCCTGTCAGGTCGCTGC	0.692		NA											21	37					0	0	0	0
TOE1	114034	broad.mit.edu	37	1	45809091	45809091	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:45809091G>T	uc009vxq.2	+	8	1833	c.1250G>T	c.(1249-1251)AGA>ATA	p.R417I	MUTYH_uc001cno.2_5'Flank|MUTYH_uc001cnk.2_5'Flank|MUTYH_uc010oll.1_5'Flank|MUTYH_uc001cnm.2_5'Flank|MUTYH_uc001cnl.2_5'Flank|MUTYH_uc009vxp.2_5'Flank|MUTYH_uc001cnn.2_5'Flank|TOE1_uc001cnq.3_RNA|TOE1_uc010olm.1_Missense_Mutation_p.R337I|TOE1_uc001cnr.3_RNA	NM_025077	NP_079353	Q96GM8	TOE1_HUMAN	target of EGR1, member 1 (nuclear)	417						nuclear speck|nucleolus	nucleic acid binding|zinc ion binding			central_nervous_system(1)	1	Acute lymphoblastic leukemia(166;0.155)					ATAGCTGATAGAGCTACCTCA	0.517		NA											40	35					5.72e-15	6.19e-15	1	0
CYP4A11	1579	broad.mit.edu	37	1	47401219	47401219	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:47401219T>G	uc001cqp.3	-	5	662	c.611A>C	c.(610-612)CAT>CCT	p.H204P	CYP4A11_uc001cqq.2_Missense_Mutation_p.H204P|CYP4A11_uc010omm.1_RNA	NM_000778	NP_000769	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A,	204					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			ovary(2)|skin(2)	4					NADH(DB00157)	GCTGCCCTGATGGCTGAAGGC	0.572		NA											17	59					0	0	0	0
FOXD2	2306	broad.mit.edu	37	1	47904276	47904276	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:47904276A>G	uc001crm.2	+	1	2588	c.469A>G	c.(469-471)ATC>GTC	p.I157V		NM_004474	NP_004465	O60548	FOXD2_HUMAN	forkhead box D2	157	Fork-head.				axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0				READ - Rectum adenocarcinoma(2;0.0908)		CTGCGAGTTCATCAGCGGCCG	0.617		NA											21	45					0	0	0	0
ZFYVE9	9372	broad.mit.edu	37	1	52810452	52810452	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:52810452G>A	uc001cto.2	+	18	4124	c.3952G>A	c.(3952-3954)GAA>AAA	p.E1318K	ZFYVE9_uc001ctp.2_Missense_Mutation_p.E1259K	NM_004799	NP_004790	O95405	ZFYV9_HUMAN	zinc finger, FYVE domain containing 9 isoform 3	1318					endocytosis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	early endosome membrane	metal ion binding|protein binding|receptor activity|serine-type peptidase activity			ovary(2)|lung(2)|central_nervous_system(2)|skin(2)	8						GTTTTTCCTAGAAAACGATGA	0.433		NA											20	49					0	0	0	0
ZYG11B	79699	broad.mit.edu	37	1	53262010	53262010	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:53262010G>C	uc001cuj.2	+	7	1576	c.1381G>C	c.(1381-1383)GAT>CAT	p.D461H	ZYG11B_uc009vzg.2_RNA|ZYG11B_uc010onj.1_Missense_Mutation_p.D452H|ZYG11B_uc009vzh.2_5'Flank	NM_024646	NP_078922	Q9C0D3	ZY11B_HUMAN	zyg-11 homolog B	461							protein binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						CAACCATGAGGATCAAAACAT	0.433		NA											11	35					0	0	0	0
PTGER3	5733	broad.mit.edu	37	1	71478156	71478156	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:71478156C>G	uc001dfg.1	-	2	1140	c.909G>C	c.(907-909)TTG>TTC	p.L303F	PTGER3_uc001dfh.1_RNA|PTGER3_uc001dfi.1_RNA|PTGER3_uc001dfj.1_RNA|PTGER3_uc001dfk.1_Missense_Mutation_p.L303F|PTGER3_uc001dfl.1_Missense_Mutation_p.L303F|PTGER3_uc009wbm.1_Missense_Mutation_p.L303F|PTGER3_uc001dfm.1_RNA|PTGER3_uc001dfn.2_Missense_Mutation_p.L303F|PTGER3_uc009wbn.1_Missense_Mutation_p.L303F|PTGER3_uc009wbo.2_Missense_Mutation_p.L303F|PTGER3_uc001dfo.2_Missense_Mutation_p.L303F|PTGER3_uc001dfp.1_Missense_Mutation_p.L303F|PTGER3_uc001dfq.2_Missense_Mutation_p.L303F	NM_198714	NP_942007	P43115	PE2R3_HUMAN	prostaglandin E receptor 3, subtype EP3 isoform	303	Helical; Name=6; (Potential).				cell death|positive regulation of fever generation|transcription, DNA-dependent	integral to plasma membrane|nuclear envelope	ligand-dependent nuclear receptor activity|prostaglandin E receptor activity			pancreas(1)|lung(1)|skin(1)	3					Bimatoprost(DB00905)	AGATCATTTTCAACATCATTA	0.289		NA											14	35					0	0	0	0
CRYZ	1429	broad.mit.edu	37	1	75188946	75188946	+	Silent	SNP	G	G	A	rs146208357	byFrequency	TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:75188946G>A	uc001dgk.2	-	4	625	c.120C>T	c.(118-120)ATC>ATT	p.I40I	CRYZ_uc001dgj.2_Silent_p.I40I|CRYZ_uc001dgl.2_Silent_p.I40I|CRYZ_uc001dgm.2_5'UTR	NM_001130042	NP_001123514	Q08257	QOR_HUMAN	crystallin, zeta isoform a	40					protein homotetramerization|visual perception|xenobiotic catabolic process	cytosol|Golgi apparatus	mRNA 3'-UTR binding|NADPH binding|NADPH:quinone reductase activity|zinc ion binding				0					Dicumarol(DB00266)	CATGGACCTTGATTAGAACCT	0.328		NA											27	67					0	0	0	0
MCOLN2	255231	broad.mit.edu	37	1	85403762	85403762	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:85403762G>C	uc001dkm.2	-	10	1355	c.1114C>G	c.(1114-1116)CTC>GTC	p.L372V	MCOLN2_uc001dkn.2_RNA	NM_153259	NP_694991	Q8IZK6	MCLN2_HUMAN	mucolipin 2	372						integral to membrane	ion channel activity			ovary(3)|upper_aerodigestive_tract(1)	4				all cancers(265;0.0111)|Epithelial(280;0.0263)|OV - Ovarian serous cystadenocarcinoma(397;0.217)		TAGTTTGTGAGATTCTAAGGA	0.338		NA											23	26					0	0	0	0
HFM1	164045	broad.mit.edu	37	1	91813030	91813030	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:91813030A>G	uc001doa.3	-	19	2310	c.2210T>C	c.(2209-2211)TTT>TCT	p.F737S	HFM1_uc009wdb.2_RNA|HFM1_uc010osu.1_Missense_Mutation_p.F416S|HFM1_uc001dob.3_5'UTR|HFM1_uc010osv.1_Missense_Mutation_p.F421S	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein	737							ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		TCCAGATGCAAAACCTGCATG	0.303		NA											8	36					0	0	0	0
EPHX4	253152	broad.mit.edu	37	1	92495681	92495681	+	Silent	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:92495681C>T	uc001don.2	+	1	149	c.45C>T	c.(43-45)CTC>CTT	p.L15L		NM_173567	NP_775838	Q8IUS5	EPHX4_HUMAN	abhydrolase domain containing 7	15						integral to membrane	hydrolase activity			central_nervous_system(1)	1						TGCTCACGCTCCGGTCCCTGC	0.701		NA											7	18					0	0	0	0
ARHGAP29	9411	broad.mit.edu	37	1	94643210	94643210	+	Missense_Mutation	SNP	G	G	A	rs141790636		TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:94643210G>A	uc001dqj.3	-	22	3232	c.2863C>T	c.(2863-2865)CGC>TGC	p.R955C	ARHGAP29_uc009wdq.1_RNA|ARHGAP29_uc001dqk.2_Missense_Mutation_p.R521C	NM_004815	NP_004806	Q52LW3	RHG29_HUMAN	PTPL1-associated RhoGAP 1	955					Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			breast(4)|skin(3)|lung(2)|upper_aerodigestive_tract(1)|ovary(1)	11		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		TTTTGCTTGCGTTCTGATTCC	0.343		NA											19	56					0	0	0	0
C1orf161	126868	broad.mit.edu	37	1	116666715	116666715	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:116666715C>A	uc001egc.1	+	4	483	c.218C>A	c.(217-219)ACA>AAA	p.T73K		NM_152367	NP_689580	Q8N8X9	MB213_HUMAN	hypothetical protein LOC126868	73											0	Lung SC(450;0.184)	all_cancers(81;0.00142)|all_lung(203;0.000139)|all_epithelial(167;0.000401)|Lung NSC(69;0.000705)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		TTCCTCGTCACAGTCCCAATA	0.577		NA											24	65					2.45e-14	2.64e-14	1	0
HAO2	51179	broad.mit.edu	37	1	119927521	119927521	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:119927521C>T	uc001ehq.1	+	5	758	c.406C>T	c.(406-408)CAG>TAG	p.Q136*	HAO2_uc001ehr.1_Nonsense_Mutation_p.Q136*	NM_001005783	NP_001005783	Q9NYQ3	HAOX2_HUMAN	hydroxyacid oxidase 2	136	FMN hydroxy acid dehydrogenase.				fatty acid alpha-oxidation	peroxisome	(S)-2-hydroxy-acid oxidase activity			ovary(2)|skin(2)	4	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.0155)|LUSC - Lung squamous cell carcinoma(189;0.0856)		TCCAGACCTGCAGCTGAACAA	0.478		NA											23	59					0	0	0	0
VPS45	11311	broad.mit.edu	37	1	150054908	150054908	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:150054908G>A	uc001etp.2	+	10	1618	c.1045G>A	c.(1045-1047)GAG>AAG	p.E349K	VPS45_uc010pbp.1_RNA|VPS45_uc010pbq.1_Missense_Mutation_p.E313K|VPS45_uc010pbs.1_Missense_Mutation_p.E244K|VPS45_uc001etq.2_Missense_Mutation_p.E169K|VPS45_uc009wlm.1_Missense_Mutation_p.E325K	NM_007259	NP_009190	Q9NRW7	VPS45_HUMAN	vacuolar protein sorting 45A	349					blood coagulation|intracellular protein transport|vesicle docking involved in exocytosis	endosome membrane|Golgi membrane|integral to membrane of membrane fraction				central_nervous_system(1)|skin(1)	2	Breast(34;0.00211)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			GAATCTGCTGGAGGTTTCAGA	0.388		NA											18	34					0	0	0	0
SETDB1	9869	broad.mit.edu	37	1	150915471	150915471	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:150915471C>G	uc001evu.2	+	7	1007	c.817C>G	c.(817-819)CAG>GAG	p.Q273E	SETDB1_uc009wmf.2_Missense_Mutation_p.Q273E|SETDB1_uc001evv.2_Missense_Mutation_p.Q273E|SETDB1_uc001evw.3_Missense_Mutation_p.Q273E|SETDB1_uc009wmg.1_Missense_Mutation_p.Q273E	NM_001145415	NP_001138887	Q15047	SETB1_HUMAN	SET domain, bifurcated 1 isoform 1	273	Tudor 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)			AGATGGGAATCAGGTCTGGCT	0.517		NA											24	75					0	0	0	0
CGN	57530	broad.mit.edu	37	1	151505015	151505015	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:151505015G>C	uc009wmw.2	+	14	2853	c.2709G>C	c.(2707-2709)AAG>AAC	p.K903N	CGN_uc010pde.1_5'Flank	NM_020770	NP_065821	Q9P2M7	CING_HUMAN	cingulin	897	Potential.					myosin complex|tight junction	actin binding|motor activity			ovary(2)|pancreas(1)	3	Ovarian(49;0.0273)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			AGGCTGAGAAGACCTCTGGAG	0.502		NA											7	36					0	0	0	0
FLG	2312	broad.mit.edu	37	1	152280813	152280813	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:152280813C>G	uc001ezu.1	-	3	6585	c.6549G>C	c.(6547-6549)CAG>CAC	p.Q2183H		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2183	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGGATCCTGACTGCCCACGGG	0.537		NA							Ichthyosis				5	361					0	0	0	0
FLG2	388698	broad.mit.edu	37	1	152329438	152329438	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:152329438C>T	uc001ezw.3	-	3	897	c.824G>A	c.(823-825)AGG>AAG	p.R275K	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	275	Ser-rich.|Filaggrin 1.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATGACTTCGCCTCCCACTGTC	0.448		NA											93	26					0	0	0	0
CRNN	49860	broad.mit.edu	37	1	152382205	152382205	+	Silent	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:152382205C>G	uc001ezx.2	-	3	1427	c.1353G>C	c.(1351-1353)GTG>GTC	p.V451V		NM_016190	NP_057274	Q9UBG3	CRNN_HUMAN	cornulin	451					cell-cell adhesion|response to heat	cytoplasm|membrane	calcium ion binding			ovary(2)|skin(1)	3	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCCTGAGGATCACTGTCTCCC	0.577		NA											16	56					0	0	0	0
S100A7A	338324	broad.mit.edu	37	1	153391671	153391671	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:153391671G>C	uc001fbt.1	+	3	249	c.192G>C	c.(190-192)AAG>AAC	p.K64N		NM_176823	NP_789793	Q86SG5	S1A7A_HUMAN	S100 calcium binding protein A7-like 1	64	2; high affinity (Potential).|EF-hand 2.					cytoplasm	calcium ion binding			skin(1)	1	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			AAAAGGACAAGAATGAGGATA	0.423		NA											24	60					0	0	0	0
KCNN3	3782	broad.mit.edu	37	1	154841649	154841649	+	Silent	SNP	T	T	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:154841649T>C	uc001ffp.2	-	1	1106	c.792A>G	c.(790-792)CAA>CAG	p.Q264Q	KCNN3_uc009wox.1_Silent_p.Q264Q	NM_002249	NP_002240	Q9UGI6	KCNN3_HUMAN	small conductance calcium-activated potassium	269						integral to membrane	calmodulin binding			lung(1)	1	all_lung(78;2.29e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.108)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00819)			AGCCAATGTTTTGGTTTTTCC	0.512		NA											71	21					0	0	0	0
FCER1A	2205	broad.mit.edu	37	1	159275900	159275900	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:159275900C>T	uc001ftq.2	+	5	553	c.454C>T	c.(454-456)CTC>TTC	p.L152F		NM_002001	NP_001992	P12319	FCERA_HUMAN	Fc fragment of IgE, high affinity I, receptor	152	Ig-like 2.|Extracellular (Potential).					integral to plasma membrane				lung(2)|skin(2)|prostate(1)	5	all_hematologic(112;0.0429)				Benzylpenicilloyl Polylysine(DB00895)|Omalizumab(DB00043)	TGGTGAAGCTCTCAAGTACTG	0.498		NA											26	57					0	0	0	0
IGSF9	57549	broad.mit.edu	37	1	159906249	159906249	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:159906249T>G	uc001fur.2	-	6	811	c.613A>C	c.(613-615)ACC>CCC	p.T205P	IGSF9_uc001fuq.2_Missense_Mutation_p.T205P	NM_001135050	NP_001128522	Q9P2J2	TUTLA_HUMAN	immunoglobulin superfamily, member 9 isoform a	205	Ig-like 2.|Extracellular (Potential).					cell junction|integral to membrane|synapse				ovary(2)|central_nervous_system(2)|large_intestine(1)	5	all_hematologic(112;0.0597)	Breast(1374;0.000126)	BRCA - Breast invasive adenocarcinoma(70;0.111)			GCTTGGCAGGTGTAGACCCCA	0.657		NA									OREG0013921	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	34					0	0	0	0
TDRD5	163589	broad.mit.edu	37	1	179603612	179603612	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:179603612G>T	uc001gnf.1	+	8	1397	c.1147G>T	c.(1147-1149)GAA>TAA	p.E383*	TDRD5_uc010pnp.1_Nonsense_Mutation_p.E383*|TDRD5_uc001gnh.1_5'UTR	NM_173533	NP_775804	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	383	Lotus/OST-HTH 3.				DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			ovary(2)|skin(2)|central_nervous_system(1)	5						TAAGAAAATAGAAGCCAAAGC	0.383		NA											22	72					6.33e-13	6.81e-13	1	0
KDM5B	10765	broad.mit.edu	37	1	202702867	202702867	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:202702867G>A	uc001gyf.2	-	23	3687	c.3571C>T	c.(3571-3573)CAA>TAA	p.Q1191*	KDM5B_uc009xag.2_Nonsense_Mutation_p.Q1227*|KDM5B_uc001gyg.1_Nonsense_Mutation_p.Q1033*	NM_006618	NP_006609	Q9UGL1	KDM5B_HUMAN	jumonji, AT rich interactive domain 1B	1191	PHD-type 2.				negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(2)|breast(2)|urinary_tract(1)	5						AGTTCACATTGAATCATAGGG	0.517		NA											21	47					0	0	0	0
KDM5B	10765	broad.mit.edu	37	1	202731854	202731854	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:202731854C>G	uc001gyf.2	-	7	1007	c.891G>C	c.(889-891)AAG>AAC	p.K297N	KDM5B_uc009xag.2_Missense_Mutation_p.K333N|KDM5B_uc001gyg.1_Missense_Mutation_p.K139N	NM_006618	NP_006609	Q9UGL1	KDM5B_HUMAN	jumonji, AT rich interactive domain 1B	297					negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(2)|breast(2)|urinary_tract(1)	5						TAGATCGACTCTTGGGCTTTT	0.294		NA											34	154					0	0	0	0
AVPR1B	553	broad.mit.edu	37	1	206225115	206225115	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:206225115G>C	uc001hds.2	+	1	833	c.675G>C	c.(673-675)GAG>GAC	p.E225D		NM_000707	NP_000698	P47901	V1BR_HUMAN	arginine vasopressin receptor 1B	225	Cytoplasmic (Potential).				activation of phospholipase C activity|elevation of cytosolic calcium ion concentration	endosome|integral to plasma membrane	protein kinase C binding|vasopressin receptor activity			ovary(2)|large_intestine(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.0312)		Desmopressin(DB00035)|Terlipressin(DB02638)|Vasopressin(DB00067)	TCTGCCATGAGATCTGTAAAA	0.607		NA											23	79					0	0	0	0
KCNH1	3756	broad.mit.edu	37	1	210857055	210857055	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:210857055C>G	uc001hib.2	-	11	2708	c.2538G>C	c.(2536-2538)AAG>AAC	p.K846N	KCNH1_uc001hic.2_Missense_Mutation_p.K819N	NM_172362	NP_758872	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H,	846	Cytoplasmic (Potential).				myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			ovary(4)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		AGTCCTCACTCTTCCCGCAAG	0.612		NA											18	62					0	0	0	0
C1orf227	149643	broad.mit.edu	37	1	213009314	213009314	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:213009314C>G	uc001hjq.2	-	2	286	c.178G>C	c.(178-180)GAT>CAT	p.D60H		NM_001024601	NP_001019772	Q537H7	CA227_HUMAN	hypothetical protein LOC149643	60											0						GTTGTGGTATCAGTAAAGGAC	0.483		NA											30	91					0	0	0	0
CENPF	1063	broad.mit.edu	37	1	214816003	214816003	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:214816003C>T	uc001hkm.2	+	12	4496	c.4322C>T	c.(4321-4323)TCA>TTA	p.S1441L		NM_016343	NP_057427	P49454	CENPF_HUMAN	centromere protein F	1537	1-2.|2 X 96 AA approximate tandem repeats.		Missing.		cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			ovary(6)|central_nervous_system(4)|large_intestine(2)|skin(1)	13				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		TATGTTGACTCATTAAAGGCC	0.423		NA											12	38					0	0	0	0
USH2A	7399	broad.mit.edu	37	1	216040365	216040365	+	Silent	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:216040365C>G	uc001hku.1	-	44	9216	c.8829G>C	c.(8827-8829)GTG>GTC	p.V2943V		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	2943	Fibronectin type-III 16.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TAGCCCACCTCACGTCGATGG	0.448		NA								HNSCC(13;0.011)			18	47					0	0	0	0
OBSCN	84033	broad.mit.edu	37	1	228509435	228509435	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:228509435G>A	uc009xez.1	+	55	14937	c.14893G>A	c.(14893-14895)GAT>AAT	p.D4965N	OBSCN_uc001hsn.2_Missense_Mutation_p.D4965N	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	4965	Ig-like 48.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				GGACCGTGCTGATGCTGGCTG	0.602		NA											22	76					0	0	0	0
RYR2	6262	broad.mit.edu	37	1	237947379	237947379	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:237947379G>A	uc001hyl.1	+	90	12487	c.12367G>A	c.(12367-12369)GAG>AAG	p.E4123K	RYR2_uc010pya.1_Missense_Mutation_p.E538K	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	4123					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GGAATTAGCAGAGAGCGTCCT	0.512		NA											19	24					0	0	0	0
CEP170	9859	broad.mit.edu	37	1	243354558	243354558	+	Silent	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:243354558C>G	uc001hzs.2	-	8	1278	c.870G>C	c.(868-870)GGG>GGC	p.G290G	CEP170_uc001hzt.2_Silent_p.G290G|CEP170_uc001hzu.2_Silent_p.G290G	NM_014812	NP_055627	Q5SW79	CE170_HUMAN	centrosomal protein 170kDa isoform alpha	290						centriole|microtubule|spindle				ovary(1)|haematopoietic_and_lymphoid_tissue(1)	2	all_neural(11;0.101)	all_cancers(173;0.003)	all cancers(7;5.81e-06)|GBM - Glioblastoma multiforme(7;0.000443)|OV - Ovarian serous cystadenocarcinoma(106;0.0101)			TAGTTACCTTCCCTGGGGTAC	0.438		NA											4	16					0	0	0	0
PGBD2	267002	broad.mit.edu	37	1	249211397	249211397	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:249211397C>T	uc001ifh.2	+	3	761	c.614C>T	c.(613-615)CCC>CTC	p.P205L	PGBD2_uc001ifg.2_Intron|PGBD2_uc009xhd.2_Missense_Mutation_p.P202L	NM_170725	NP_733843	Q6P3X8	PGBD2_HUMAN	hypothetical protein LOC267002 isoform a	205										ovary(1)	1	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.012)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			GAAACCTCTCCCGATTCACAT	0.398		NA											34	120					0	0	0	0
AKR1C4	1109	broad.mit.edu	37	10	5254582	5254582	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr10:5254582G>C	uc001ihw.2	+	6	607	c.574G>C	c.(574-576)GAA>CAA	p.E192Q		NM_001818	NP_001809	P17516	AK1C4_HUMAN	aldo-keto reductase family 1, member C4	192					androgen metabolic process|bile acid biosynthetic process	cytosol	aldo-keto reductase (NADP) activity|androsterone dehydrogenase (B-specific) activity|bile acid transmembrane transporter activity|chlordecone reductase activity|electron carrier activity			ovary(1)	1					NADH(DB00157)	TCTAAAGGTAGAATGTCATCC	0.348		NA											11	30					0	0	0	0
PCDH15	65217	broad.mit.edu	37	10	55912906	55912906	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr10:55912906C>A	uc001jju.1	-	14	2133	c.1738G>T	c.(1738-1740)GCA>TCA	p.A580S	PCDH15_uc010qhq.1_Missense_Mutation_p.A585S|PCDH15_uc010qhr.1_Missense_Mutation_p.A580S|PCDH15_uc010qhs.1_Missense_Mutation_p.A592S|PCDH15_uc010qht.1_Missense_Mutation_p.A587S|PCDH15_uc010qhu.1_Missense_Mutation_p.A580S|PCDH15_uc001jjv.1_Missense_Mutation_p.A558S|PCDH15_uc010qhv.1_Missense_Mutation_p.A580S|PCDH15_uc010qhw.1_Missense_Mutation_p.A543S|PCDH15_uc010qhx.1_Missense_Mutation_p.A580S|PCDH15_uc010qhy.1_Missense_Mutation_p.A585S|PCDH15_uc010qhz.1_Missense_Mutation_p.A580S|PCDH15_uc010qia.1_Missense_Mutation_p.A558S|PCDH15_uc010qib.1_Missense_Mutation_p.A558S|PCDH15_uc001jjw.2_Missense_Mutation_p.A580S	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	580	Cadherin 5.|Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				ACCGTGAGTGCGTAAGTCCGC	0.488		NA								HNSCC(58;0.16)			12	31					0.000978159	0.00100873	1	0
BICC1	80114	broad.mit.edu	37	10	60272997	60272997	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr10:60272997G>A	uc001jki.1	+	1	94	c.94G>A	c.(94-96)GAG>AAG	p.E32K		NM_001080512	NP_001073981	Q9H694	BICC1_HUMAN	bicaudal C homolog 1	32					multicellular organismal development		RNA binding			ovary(2)|lung(1)|skin(1)	4						GCCCGGCTCCGAGGACGACTT	0.697		NA											13	18					0	0	0	0
PLAU	5328	broad.mit.edu	37	10	75672797	75672797	+	Silent	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr10:75672797G>A	uc001jwa.2	+	5	455	c.309G>A	c.(307-309)ACG>ACA	p.T103T	C10orf55_uc001jvz.1_Intron|PLAU_uc010qkw.1_Silent_p.T86T|PLAU_uc010qkx.1_Silent_p.T17T|PLAU_uc001jwb.2_RNA|PLAU_uc001jwc.2_Silent_p.T103T|PLAU_uc009xrq.1_Silent_p.T67T	NM_002658	NP_002649	P00749	UROK_HUMAN	plasminogen activator, urokinase isoform 1	103	Kringle.				blood coagulation|chemotaxis|fibrinolysis|proteolysis|regulation of cell adhesion mediated by integrin|regulation of receptor activity|regulation of smooth muscle cell migration|regulation of smooth muscle cell-matrix adhesion|signal transduction	cell surface|extracellular space|plasma membrane	serine-type endopeptidase activity			ovary(2)|kidney(1)	3	Prostate(51;0.0112)				Amiloride(DB00594)|Urokinase(DB00013)	TTCAGCAAACGTACCATGCCC	0.572		NA											10	47					0	0	0	0
SEMA4G	57715	broad.mit.edu	37	10	102743390	102743390	+	Silent	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr10:102743390G>C	uc001krw.1	+	14	2418	c.2034G>C	c.(2032-2034)GTG>GTC	p.V678V	SEMA4G_uc001krv.2_RNA|SEMA4G_uc001krx.2_Intron|MRPL43_uc001kry.1_Intron|MRPL43_uc010qpu.1_Intron|MRPL43_uc001krz.1_Intron|MRPL43_uc001ksa.1_Intron|MRPL43_uc001ksb.1_Intron	NM_017893	NP_060363	Q9NTN9	SEM4G_HUMAN	semaphorin 4G	673	Extracellular (Potential).				cell differentiation|nervous system development	integral to membrane	receptor activity			breast(1)	1		Colorectal(252;0.234)		Epithelial(162;3.71e-09)|all cancers(201;2.1e-07)		CACCTGATGTGAGACTGCTCT	0.637		NA											3	21					0	0	0	0
PDCD11	22984	broad.mit.edu	37	10	105174042	105174042	+	Silent	SNP	T	T	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr10:105174042T>C	uc001kwy.1	+	11	1413	c.1326T>C	c.(1324-1326)GCT>GCC	p.A442A		NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	442					mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		TTATTGAAGCTCAGTACCTTA	0.433		NA											16	28					0	0	0	0
PNLIPRP3	119548	broad.mit.edu	37	10	118202613	118202613	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr10:118202613G>T	uc001lcl.3	+	3	352	c.251G>T	c.(250-252)GGA>GTA	p.G84V		NM_001011709	NP_001011709	Q17RR3	LIPR3_HUMAN	pancreatic lipase-related protein 3 precursor	84					lipid catabolic process	extracellular region	triglyceride lipase activity			ovary(1)	1				all cancers(201;0.0131)		TCATATTTTGGAACAGACAAG	0.348		NA											9	31					1.13e-05	1.18e-05	1	0
LHPP	64077	broad.mit.edu	37	10	126172787	126172787	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr10:126172787C>T	uc001lhs.1	+	2	225	c.205C>T	c.(205-207)CAG>TAG	p.Q69*	LHPP_uc001lht.1_Nonsense_Mutation_p.Q69*|LHPP_uc009yai.1_Nonsense_Mutation_p.Q69*	NM_022126	NP_071409	Q9H008	LHPP_HUMAN	phospholysine phosphohistidine inorganic	69					protein dephosphorylation	cytosol|nucleus	inorganic diphosphatase activity|magnesium ion binding|phosphohistidine phosphatase activity|protein homodimerization activity				0		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.163)|Colorectal(40;0.187)		GGGGCAGCTTCAGAGGCTGGG	0.627		NA											13	51					0	0	0	0
KRTAP5-1	387264	broad.mit.edu	37	11	1606411	1606411	+	Silent	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:1606411G>A	uc001ltu.1	-	1	103	c.69C>T	c.(67-69)GGC>GGT	p.G23G	LOC338651_uc009ycx.1_Intron|LOC338651_uc001ltt.1_Intron	NM_001005922	NP_001005922	Q6L8H4	KRA51_HUMAN	keratin associated protein 5-1	23						keratin filament					0		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		CGGAGCCACAGCCCCCACAGC	0.677		NA											3	64					0	0	0	0
KRTAP5-3	387266	broad.mit.edu	37	11	1628959	1628959	+	Silent	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:1628959G>A	uc001ltw.1	-	1	735	c.657C>T	c.(655-657)TGC>TGT	p.C219C		NM_001012708	NP_001012726	Q6L8H2	KRA53_HUMAN	keratin associated protein 5-3	219	11 X 4 AA repeats of C-C-X-P.|10.					keratin filament				ovary(2)	2		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000618)|Lung(200;0.0684)|LUSC - Lung squamous cell carcinoma(625;0.0822)		AGCAGGGCTTgcagcagctgg	0.294		NA											6	169					0	0	0	0
KRTAP5-4	387267	broad.mit.edu	37	11	1642730	1642730	+	Silent	SNP	A	A	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:1642730A>G	uc009ycy.1	-	4	819	c.732T>C	c.(730-732)GGT>GGC	p.G244G		NM_001012709	NP_001012727	Q6L8H1	KRA54_HUMAN	keratin associated protein 5-4	258	9 X 4 AA repeats of C-C-X-P.					keratin filament					0		all_epithelial(84;0.00819)|Breast(177;0.00832)|Ovarian(85;0.0256)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		ATGACCCACAACCTGAGGAGG	0.597		NA											6	108					0	0	0	0
KRTAP5-4	387267	broad.mit.edu	37	11	1642736	1642736	+	Silent	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:1642736G>A	uc009ycy.1	-	4	813	c.726C>T	c.(724-726)TCC>TCT	p.S242S		NM_001012709	NP_001012727	Q6L8H1	KRA54_HUMAN	keratin associated protein 5-4	256	9 X 4 AA repeats of C-C-X-P.					keratin filament					0		all_epithelial(84;0.00819)|Breast(177;0.00832)|Ovarian(85;0.0256)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		CACAACCTGAGGAGGAGCAGC	0.597		NA											6	114					0	0	0	0
KRTAP5-4	387267	broad.mit.edu	37	11	1642740	1642740	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:1642740G>C	uc009ycy.1	-	4	809	c.722C>G	c.(721-723)TCC>TGC	p.S241C		NM_001012709	NP_001012727	Q6L8H1	KRA54_HUMAN	keratin associated protein 5-4	255	9 X 4 AA repeats of C-C-X-P.					keratin filament					0		all_epithelial(84;0.00819)|Breast(177;0.00832)|Ovarian(85;0.0256)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		ACCTGAGGAGGAGCAGCAGGG	0.597		NA											6	115					0	0	0	0
KRTAP5-4	387267	broad.mit.edu	37	11	1642817	1642817	+	Silent	SNP	A	A	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:1642817A>G	uc009ycy.1	-	4	732	c.645T>C	c.(643-645)GGT>GGC	p.G215G		NM_001012709	NP_001012727	Q6L8H1	KRA54_HUMAN	keratin associated protein 5-4	229	9 X 4 AA repeats of C-C-X-P.					keratin filament					0		all_epithelial(84;0.00819)|Breast(177;0.00832)|Ovarian(85;0.0256)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		ATGACCCACAACCTGAGGAGG	0.612		NA											4	118					0	0	0	0
KRTAP5-4	387267	broad.mit.edu	37	11	1642823	1642823	+	Silent	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:1642823G>A	uc009ycy.1	-	4	726	c.639C>T	c.(637-639)TCC>TCT	p.S213S		NM_001012709	NP_001012727	Q6L8H1	KRA54_HUMAN	keratin associated protein 5-4	227	9 X 4 AA repeats of C-C-X-P.					keratin filament					0		all_epithelial(84;0.00819)|Breast(177;0.00832)|Ovarian(85;0.0256)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		CACAACCTGAGGAGGAGCAGC	0.617		NA											12	117					0	0	0	0
KRTAP5-4	387267	broad.mit.edu	37	11	1643252	1643252	+	Silent	SNP	A	A	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:1643252A>G	uc009ycy.1	-	1	117	c.30T>C	c.(28-30)TGT>TGC	p.C10C		NM_001012709	NP_001012727	Q6L8H1	KRA54_HUMAN	keratin associated protein 5-4	24						keratin filament					0		all_epithelial(84;0.00819)|Breast(177;0.00832)|Ovarian(85;0.0256)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		agccagagccacagcccccac	0.254		NA											101	33					0	0	0	0
OR52K1	390036	broad.mit.edu	37	11	4510323	4510323	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:4510323C>G	uc001lza.1	+	1	193	c.193C>G	c.(193-195)CTG>GTG	p.L65V		NM_001005171	NP_001005171	Q8NGK4	O52K1_HUMAN	olfactory receptor, family 52, subfamily K,	65	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;1.76e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0836)|LUSC - Lung squamous cell carcinoma(625;0.192)		GTACCTCTTTCTGGCCATGTT	0.488		NA											34	22					0	0	0	0
OR51A7	119687	broad.mit.edu	37	11	4929349	4929349	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:4929349C>A	uc010qyq.1	+	1	750	c.750C>A	c.(748-750)TTC>TTA	p.F250L		NM_001004749	NP_001004749	Q8NH64	O51A7_HUMAN	olfactory receptor, family 51, subfamily A,	250	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGCTCACCTTCTATGTGCCCA	0.483		NA											40	56					4.18e-13	4.5e-13	1	0
KCNA4	3739	broad.mit.edu	37	11	30034073	30034073	+	Silent	SNP	G	G	C	rs60942363		TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:30034073G>C	uc001msk.2	-	2	1305	c.153C>G	c.(151-153)GTC>GTG	p.V51V		NM_002233	NP_002224	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related	51						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CGCTACCTTCGACAGCAGCTG	0.677		NA											14	16					0	0	0	0
TTC17	55761	broad.mit.edu	37	11	43411297	43411297	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:43411297C>G	uc001mxi.2	+	3	359	c.345C>G	c.(343-345)ATC>ATG	p.I115M	TTC17_uc001mxh.2_Missense_Mutation_p.I115M|TTC17_uc010rfj.1_Missense_Mutation_p.I58M	NM_018259	NP_060729	Q96AE7	TTC17_HUMAN	tetratricopeptide repeat domain 17	115							binding			ovary(5)	5						CAGACTGCATCAAAGCCAAGG	0.398		NA											27	134					0	0	0	0
OR4A16	81327	broad.mit.edu	37	11	55111514	55111514	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:55111514T>A	uc010rie.1	+	1	838	c.838T>A	c.(838-840)TTG>ATG	p.L280M		NM_001005274	NP_001005274	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A,	280	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(2)|pancreas(1)	3						CACACTCATGTTGAATCCTTT	0.318		NA											13	54					0	0	0	0
SPRYD5	84767	broad.mit.edu	37	11	55658863	55658863	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:55658863G>C	uc010rip.1	+	7	1206	c.1114G>C	c.(1114-1116)GAT>CAT	p.D372H	SPRYD5_uc010riq.1_Missense_Mutation_p.D229H	NM_032681	NP_116070	Q9BSJ1	SPRY5_HUMAN	SPRY domain containing 5	372	B30.2/SPRY.					intracellular	zinc ion binding				0		all_epithelial(135;0.226)				TGACAAGATAGATGGAGAGGA	0.443		NA											17	63					0	0	0	0
OR8H3	390152	broad.mit.edu	37	11	55890553	55890553	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:55890553G>C	uc001nii.1	+	1	705	c.705G>C	c.(703-705)CAG>CAC	p.Q235H		NM_001005201	NP_001005201	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H,	235	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00693)					CAGGAAAGCAGAAAGCTTTCT	0.413		NA											19	117					0	0	0	0
SSRP1	6749	broad.mit.edu	37	11	57097867	57097867	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:57097867C>T	uc001njt.2	-	11	1600	c.1333G>A	c.(1333-1335)GAT>AAT	p.D445N		NM_003146	NP_003137	Q08945	SSRP1_HUMAN	structure specific recognition protein 1	445	Asp/Glu-rich (acidic).				DNA repair|DNA replication|positive regulation of viral transcription|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|cytoplasm|nucleoplasm	DNA binding|protein binding			ovary(2)	2						TGGTCCTCATCAGAGTCAGCA	0.537		NA											4	31					0	0	0	0
ZDHHC5	25921	broad.mit.edu	37	11	57466638	57466638	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:57466638C>T	uc001nkx.1	+	11	2986	c.1730C>T	c.(1729-1731)TCG>TTG	p.S577L	ZDHHC5_uc001nky.1_Missense_Mutation_p.S524L|ZDHHC5_uc001nkz.1_Missense_Mutation_p.S391L	NM_015457	NP_056272	Q9C0B5	ZDHC5_HUMAN	zinc finger, DHHC domain containing 5	577						integral to membrane	acyltransferase activity|zinc ion binding			skin(1)	1						ACACCAGGCTCGGGCCATGCC	0.597		NA											34	144					0	0	0	0
OR5B3	441608	broad.mit.edu	37	11	58170596	58170596	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:58170596G>C	uc010rkf.1	-	1	287	c.287C>G	c.(286-288)GCT>GGT	p.A96G		NM_001005469	NP_001005469	Q8NH48	OR5B3_HUMAN	olfactory receptor, family 5, subfamily B,	96	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				CATTTGAGCAGCACATGCATT	0.448		NA											24	87					0	0	0	0
OR5A2	219981	broad.mit.edu	37	11	59190242	59190242	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:59190242A>G	uc010rkt.1	-	1	185	c.185T>C	c.(184-186)TTC>TCC	p.F62S		NM_001001954	NP_001001954	Q8NGI9	OR5A2_HUMAN	olfactory receptor, family 5, subfamily A,	62	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						ACTGAGGAAGAAGTACATGGG	0.488		NA											29	52					0	0	0	0
OR4D9	390199	broad.mit.edu	37	11	59283060	59283060	+	Silent	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:59283060G>C	uc010rkv.1	+	1	675	c.675G>C	c.(673-675)CTG>CTC	p.L225L		NM_001004711	NP_001004711	Q8NGE8	OR4D9_HUMAN	olfactory receptor, family 4, subfamily D,	225	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TGATGATGCTGAGGTCTCACA	0.488		NA											32	167					0	0	0	0
MS4A3	932	broad.mit.edu	37	11	59829989	59829989	+	Silent	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:59829989C>T	uc001nom.2	+	3	333	c.205C>T	c.(205-207)CTG>TTG	p.L69L	MS4A3_uc001non.2_Intron|MS4A3_uc001noo.2_Intron	NM_006138	NP_006129	Q96HJ5	MS4A3_HUMAN	membrane-spanning 4-domains, subfamily A, member	69	Helical; (Potential).					endomembrane system|integral to membrane|perinuclear region of cytoplasm	protein binding|receptor activity			ovary(2)|skin(1)	3		all_epithelial(135;0.245)				GGGTGTCTTTCTGGGTTCCTT	0.453		NA											25	102					0	0	0	0
MS4A14	84689	broad.mit.edu	37	11	60183118	60183118	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:60183118G>C	uc001npj.2	+	5	1242	c.677G>C	c.(676-678)AGA>ACA	p.R226T	MS4A14_uc001npi.2_Missense_Mutation_p.R114T|MS4A14_uc001npn.2_5'UTR|MS4A14_uc001npk.2_Missense_Mutation_p.R209T|MS4A14_uc001npl.2_5'UTR|MS4A14_uc001npm.2_5'UTR	NM_032597	NP_115986	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member	226						integral to membrane	receptor activity			breast(1)	1						AATAAAGGTAGAGAATTTGTG	0.403		NA											22	87					0	0	0	0
MS4A14	84689	broad.mit.edu	37	11	60183186	60183186	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:60183186G>A	uc001npj.2	+	5	1310	c.745G>A	c.(745-747)GAA>AAA	p.E249K	MS4A14_uc001npi.2_Missense_Mutation_p.E137K|MS4A14_uc001npn.2_5'UTR|MS4A14_uc001npk.2_Missense_Mutation_p.E232K|MS4A14_uc001npl.2_5'UTR|MS4A14_uc001npm.2_5'UTR	NM_032597	NP_115986	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member	249						integral to membrane	receptor activity			breast(1)	1						GGAAGAAATTGAACCTTTGCC	0.383		NA											11	91					0	0	0	0
AHNAK	79026	broad.mit.edu	37	11	62287084	62287084	+	Silent	SNP	C	C	T	rs149805243		TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:62287084C>T	uc001ntl.2	-	5	15105	c.14805G>A	c.(14803-14805)CCG>CCA	p.P4935P	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	4935					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				CTTCTAACTTCGGACCTGAAA	0.458		NA											24	118					0	0	0	0
COX8A	1351	broad.mit.edu	37	11	63743743	63743743	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:63743743C>T	uc001nye.2	+	2	235	c.161C>T	c.(160-162)CCA>CTA	p.P54L		NM_004074	NP_004065	P10176	COX8A_HUMAN	cytochrome c oxidase subunit VIIIa precursor	54	Helical; (By similarity).				respiratory electron transport chain	integral to membrane|mitochondrial inner membrane	cytochrome-c oxidase activity				0						TTCCTCCTGCCAGCGGGCTGG	0.597		NA											100	135					0	0	0	0
SCYL1	57410	broad.mit.edu	37	11	65293810	65293810	+	Silent	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:65293810C>T	uc001oea.1	+	4	668	c.591C>T	c.(589-591)GTC>GTT	p.V197V	SCYL1_uc009yqk.2_Silent_p.V197V|SCYL1_uc001oeb.1_Silent_p.V197V|SCYL1_uc001oec.1_Silent_p.V197V|SCYL1_uc001oed.1_Silent_p.V54V	NM_020680	NP_065731	Q96KG9	NTKL_HUMAN	SCY1-like 1 isoform A	197	Protein kinase.				regulation of transcription, DNA-dependent|retrograde vesicle-mediated transport, Golgi to ER|transcription, DNA-dependent	cis-Golgi network|COPI vesicle coat|ER-Golgi intermediate compartment|microtubule organizing center|nucleus	ATP binding|DNA binding|protein tyrosine kinase activity			skin(1)	1						GCAGAGTGGTCAGAGAGAAGT	0.662		NA											5	33					0	0	0	0
ACTN3	89	broad.mit.edu	37	11	66328070	66328070	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:66328070C>G	uc001oio.1	+	15	1722	c.1704C>G	c.(1702-1704)TTC>TTG	p.F568L	ACTN3_uc010rpi.1_RNA	NM_001104	NP_001095	Q08043	ACTN3_HUMAN	actinin, alpha 3	568	Spectrin 3.				focal adhesion assembly|muscle filament sliding|regulation of apoptosis	actin filament|cytosol|focal adhesion|pseudopodium	actin binding|calcium ion binding|integrin binding|protein homodimerization activity|structural constituent of muscle				0						ACGATCAGTTCAAGGCAACAC	0.547		NA											19	37					0	0	0	0
LRP5	4041	broad.mit.edu	37	11	68179074	68179074	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:68179074C>T	uc001ont.2	+	11	2564	c.2489C>T	c.(2488-2490)TCG>TTG	p.S830L	LRP5_uc009ysg.2_Missense_Mutation_p.S240L	NM_002335	NP_002326	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein	830	LDL-receptor class B 14.|Beta-propeller 3.|Extracellular (Potential).				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			lung(2)|skin(2)|ovary(1)|pancreas(1)|breast(1)	7						ATGATCGAGTCGTCCAACATG	0.657		NA											5	56					0	0	0	0
ANO1	55107	broad.mit.edu	37	11	70028776	70028776	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:70028776G>A	uc001opj.2	+	24	2877	c.2572G>A	c.(2572-2574)GAG>AAG	p.E858K	ANO1_uc001opl.1_RNA|ANO1_uc010rqk.1_Missense_Mutation_p.E567K|ANO1_uc010rql.1_Missense_Mutation_p.E32K	NM_018043	NP_060513	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	858	Extracellular (Potential).				multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			ovary(1)|pancreas(1)	2						CCTGGGCTACGAGGTGCAGAT	0.587		NA											7	183					0	0	0	0
PGR	5241	broad.mit.edu	37	11	100933223	100933223	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:100933223C>T	uc001pgh.2	-	4	2910	c.2167G>A	c.(2167-2169)GAG>AAG	p.E723K	PGR_uc001pgg.2_Missense_Mutation_p.E104K|PGR_uc001pgi.2_Intron|PGR_uc009yww.1_Intron|PGR_uc001pgj.2_RNA|PGR_uc009ywx.1_RNA	NM_000926	NP_000917	P06401	PRGR_HUMAN	progesterone receptor	723	Steroid-binding.				cell-cell signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	enzyme binding|receptor binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			lung(1)|liver(1)|central_nervous_system(1)|pancreas(1)	4		Acute lymphoblastic leukemia(157;0.000885)|all_hematologic(158;0.014)		LUSC - Lung squamous cell carcinoma(1;0.0387)|BRCA - Breast invasive adenocarcinoma(274;0.124)|OV - Ovarian serous cystadenocarcinoma(223;0.148)|Lung(307;0.164)	Desogestrel(DB00304)|Drospirenone(DB01395)|Dydrogesterone(DB00378)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Mifepristone(DB00834)|Norethindrone(DB00717)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)	AGTTGCCTCTCGCCTAGTTGA	0.358		NA											26	56					0	0	0	0
RNF214	257160	broad.mit.edu	37	11	117110556	117110556	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:117110556C>T	uc001pqt.2	+	4	703	c.658C>T	c.(658-660)CAA>TAA	p.Q220*	RNF214_uc001pqu.2_Nonsense_Mutation_p.Q220*|RNF214_uc010rxf.1_Nonsense_Mutation_p.Q65*	NM_207343	NP_997226	Q8ND24	RN214_HUMAN	ring finger protein 214	220	Potential.						zinc ion binding				0	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.88e-05)|Epithelial(105;0.000397)|all cancers(92;0.00258)		AAACACAGATCAAGATATTGA	0.318		NA											6	17					0	0	0	0
CACNA1C	775	broad.mit.edu	37	12	2693722	2693722	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr12:2693722G>A	uc009zdu.1	+	16	2591	c.2278G>A	c.(2278-2280)GAG>AAG	p.E760K	CACNA1C_uc009zdv.1_Missense_Mutation_p.E757K|CACNA1C_uc001qkb.2_Missense_Mutation_p.E760K|CACNA1C_uc001qkc.2_Missense_Mutation_p.E760K|CACNA1C_uc001qke.2_Missense_Mutation_p.E760K|CACNA1C_uc001qkf.2_Missense_Mutation_p.E760K|CACNA1C_uc001qjz.2_Missense_Mutation_p.E760K|CACNA1C_uc001qkd.2_Missense_Mutation_p.E760K|CACNA1C_uc001qkg.2_Missense_Mutation_p.E760K|CACNA1C_uc009zdw.1_Missense_Mutation_p.E760K|CACNA1C_uc001qkh.2_Missense_Mutation_p.E760K|CACNA1C_uc001qkl.2_Missense_Mutation_p.E760K|CACNA1C_uc001qkn.2_Missense_Mutation_p.E760K|CACNA1C_uc001qko.2_Missense_Mutation_p.E760K|CACNA1C_uc001qkp.2_Missense_Mutation_p.E760K|CACNA1C_uc001qkr.2_Missense_Mutation_p.E760K|CACNA1C_uc001qku.2_Missense_Mutation_p.E760K|CACNA1C_uc001qkq.2_Missense_Mutation_p.E760K|CACNA1C_uc001qks.2_Missense_Mutation_p.E760K|CACNA1C_uc001qkt.2_Missense_Mutation_p.E760K|CACNA1C_uc001qka.1_Missense_Mutation_p.E295K|CACNA1C_uc001qki.1_Missense_Mutation_p.E496K|CACNA1C_uc001qkj.1_Missense_Mutation_p.E496K|CACNA1C_uc001qkk.1_Missense_Mutation_p.E496K|CACNA1C_uc001qkm.1_Missense_Mutation_p.E496K|CACNA1C_uc001qkw.2_Missense_Mutation_p.E49K	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	760	Cytoplasmic (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	GGCTGATGCTGAGAGCCTCAC	0.433		NA											13	45					0	0	0	0
CASC1	55259	broad.mit.edu	37	12	25274696	25274696	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr12:25274696C>T	uc001rgl.2	-	10	1294	c.1212G>A	c.(1210-1212)ATG>ATA	p.M404I	CASC1_uc001rgk.2_Missense_Mutation_p.M410I|CASC1_uc001rgm.3_Missense_Mutation_p.M468I|CASC1_uc001rgj.2_Missense_Mutation_p.M364I|CASC1_uc010sje.1_Missense_Mutation_p.M345I|CASC1_uc010sjf.1_Missense_Mutation_p.M292I|CASC1_uc010sjg.1_Missense_Mutation_p.M404I	NM_001082973	NP_001076442	Q6TDU7	CASC1_HUMAN	cancer susceptibility candidate 1 isoform b	404										ovary(2)	2	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Melanoma(3;0.0301)|Colorectal(261;0.11)		OV - Ovarian serous cystadenocarcinoma(3;7.42e-20)|Epithelial(3;7.58e-16)|all cancers(3;1.07e-13)			CTTCCACAATCATCCATCCCT	0.353		NA											22	46					0	0	0	0
DENND5B	160518	broad.mit.edu	37	12	31555438	31555438	+	Silent	SNP	G	G	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr12:31555438G>T	uc001rki.1	-	15	3129	c.2943C>A	c.(2941-2943)ACC>ACA	p.T981T	DENND5B_uc001rkh.1_Silent_p.T1016T|DENND5B_uc009zjq.1_Intron	NM_144973	NP_659410	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	981	PLAT.					integral to membrane				ovary(1)|central_nervous_system(1)	2						CTACCTCAAAGGTCATTTCGA	0.398		NA											39	46					2.48e-24	2.69e-24	1	0
LRRK2	120892	broad.mit.edu	37	12	40689444	40689444	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr12:40689444G>A	uc001rmg.3	+	23	3215	c.3094G>A	c.(3094-3096)GAA>AAA	p.E1032K	LRRK2_uc001rmh.1_Missense_Mutation_p.E654K|LRRK2_uc009zjw.2_5'UTR	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	1032	LRR 2.				activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				ACAGCTATGTGAAGTAAATTT	0.343		NA											5	29					0	0	0	0
PDZRN4	29951	broad.mit.edu	37	12	41967475	41967475	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr12:41967475G>A	uc010skn.1	+	10	2365	c.2297G>A	c.(2296-2298)CGA>CAA	p.R766Q	PDZRN4_uc001rmq.3_Missense_Mutation_p.R707Q|PDZRN4_uc009zjz.2_Missense_Mutation_p.R705Q|PDZRN4_uc001rmr.2_Missense_Mutation_p.R592Q	NM_013377	NP_037509	Q6ZMN7	PZRN4_HUMAN	PDZ domain containing RING finger 4 isoform 2	965							ubiquitin-protein ligase activity|zinc ion binding			lung(3)|skin(3)|ovary(2)|large_intestine(1)|kidney(1)|pancreas(1)	11	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				TTCATGATGCGAAGCAGGTTA	0.507		NA											12	32					0	0	0	0
MLL2	8085	broad.mit.edu	37	12	49436573	49436573	+	Silent	SNP	G	G	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr12:49436573G>T	uc001rta.3	-	26	5733	c.5733C>A	c.(5731-5733)ACC>ACA	p.T1911T		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	1911					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						CTAGGCCAGGGGTTCCACAAC	0.542		NA	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			24	58					1.66e-10	1.78e-10	1	0
METTL1	4234	broad.mit.edu	37	12	58163602	58163602	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr12:58163602G>A	uc010ssd.1	-	3	460	c.412C>T	c.(412-414)CGT>TGT	p.R138C	CYP27B1_uc001spz.1_5'Flank|CYP27B1_uc001sqa.1_5'Flank|METTL1_uc009zqc.2_Intron|FAM119B_uc001sqf.2_5'Flank|FAM119B_uc001sqg.2_5'Flank|FAM119B_uc009zqd.2_5'Flank	NM_005371	NP_005362	Q9UBP6	TRMB_HUMAN	methyltransferase-like protein 1 isoform a	138						cytoplasm|nucleus	protein binding|tRNA (guanine-N7-)-methyltransferase activity|tRNA binding				0	all_cancers(7;6.73e-81)|Lung NSC(6;1.07e-25)|all_lung(6;8.25e-24)|all_epithelial(6;4.6e-17)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.211)			GCATTGCTACGGAGACAGGCG	0.607		NA											7	31					0	0	0	0
SRGAP1	57522	broad.mit.edu	37	12	64383777	64383777	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr12:64383777G>C	uc010ssp.1	+	3	407	c.351G>C	c.(349-351)TTG>TTC	p.L117F	SRGAP1_uc001srt.2_Missense_Mutation_p.L117F|SRGAP1_uc001srv.2_Missense_Mutation_p.L77F	NM_020762	NP_065813	Q7Z6B7	SRGP1_HUMAN	SLIT-ROBO Rho GTPase activating protein 1	117					axon guidance	cytosol				ovary(2)|central_nervous_system(2)	4			GBM - Glioblastoma multiforme(3;0.000139)|BRCA - Breast invasive adenocarcinoma(9;0.225)	GBM - Glioblastoma multiforme(28;0.0608)		ATGCAACCTTGAGTGACATCT	0.423		NA											28	63					0	0	0	0
DDX54	79039	broad.mit.edu	37	12	113599751	113599751	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr12:113599751C>G	uc001tup.2	-	18	2275	c.2247G>C	c.(2245-2247)AAG>AAC	p.K749N	DDX54_uc001tuq.3_Missense_Mutation_p.K749N	NM_024072	NP_076977	Q8TDD1	DDX54_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 54	749					estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nucleolus	ATP binding|ATP-dependent RNA helicase activity|estrogen receptor binding|RNA binding|transcription corepressor activity			skin(2)|central_nervous_system(1)	3						TCTTAATCTTCTTCTTGTCTT	0.602		NA											40	100					0	0	0	0
RNF10	9921	broad.mit.edu	37	12	120995255	120995255	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr12:120995255G>C	uc001typ.3	+	5	1299	c.816G>C	c.(814-816)AAG>AAC	p.K272N	RNF10_uc010szk.1_RNA|RNF10_uc001tyq.3_Missense_Mutation_p.K178N	NM_014868	NP_055683	Q8N5U6	RNF10_HUMAN	ring finger protein 10	272					negative regulation of Schwann cell proliferation|positive regulation of myelination|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription regulatory region DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CTGTGCATAAGAAGGATCTCA	0.443		NA											34	81					0	0	0	0
RNF10	9921	broad.mit.edu	37	12	120995384	120995384	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr12:120995384G>A	uc001typ.3	+	6	1349	c.866G>A	c.(865-867)GGT>GAT	p.G289D	RNF10_uc010szk.1_RNA|RNF10_uc001tyq.3_Missense_Mutation_p.G195D	NM_014868	NP_055683	Q8N5U6	RNF10_HUMAN	ring finger protein 10	289					negative regulation of Schwann cell proliferation|positive regulation of myelination|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription regulatory region DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TATGTTGTTGGTGATACCATT	0.448		NA											31	109					0	0	0	0
NCOR2	9612	broad.mit.edu	37	12	124957522	124957522	+	Silent	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr12:124957522C>T	uc010tba.1	-	4	684	c.567G>A	c.(565-567)CAG>CAA	p.Q189Q	NCOR2_uc010tay.1_Silent_p.Q189Q|NCOR2_uc010taz.1_Silent_p.Q189Q|NCOR2_uc010tbb.1_Silent_p.Q189Q|NCOR2_uc010tbc.1_Silent_p.Q189Q|NCOR2_uc001ugj.1_Silent_p.Q189Q|NCOR2_uc001ugk.1_Silent_p.Q189Q	NM_001077261	NP_001070729	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 2	189	Potential.				cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		GCTTAGAGATCTGCTGCTCTA	0.577		NA											30	77					0	0	0	0
SLC15A4	121260	broad.mit.edu	37	12	129293444	129293444	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr12:129293444G>C	uc001uhu.2	-	5	1200	c.1147C>G	c.(1147-1149)CTG>GTG	p.L383V	SLC15A4_uc001uhv.2_RNA	NM_145648	NP_663623	Q8N697	S15A4_HUMAN	solute carrier family 15, member 4	383	Helical; (Potential).				oligopeptide transport|protein transport	integral to membrane|lysosomal membrane	peptide:hydrogen symporter activity				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.69e-06)|Epithelial(86;1.17e-05)|all cancers(50;5.07e-05)		TTGTCCTTCAGAGGGATGAGC	0.557		NA											19	67					0	0	0	0
RIMBP2	23504	broad.mit.edu	37	12	130926553	130926553	+	Silent	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr12:130926553G>A	uc001uil.2	-	8	1457	c.1293C>T	c.(1291-1293)ATC>ATT	p.I431I	RIMBP2_uc001uim.2_Silent_p.I339I|RIMBP2_uc001uin.1_Silent_p.I90I	NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	431	Fibronectin type-III 2.					cell junction|synapse		p.I431I(1)		upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		CGGCCTTGACGATGTCGAACT	0.567		NA											11	51					0	0	0	0
XPO4	64328	broad.mit.edu	37	13	21417053	21417053	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr13:21417053C>G	uc001unq.3	-	6	744	c.708G>C	c.(706-708)TGG>TGC	p.W236C	XPO4_uc010tcr.1_Missense_Mutation_p.W162C	NM_022459	NP_071904	Q9C0E2	XPO4_HUMAN	exportin 4	236					protein transport	cytoplasm|nucleus	protein binding			large_intestine(1)|ovary(1)|kidney(1)	3		all_cancers(29;5.05e-24)|all_epithelial(30;5.56e-20)|all_lung(29;2.38e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000521)|Epithelial(112;0.000892)|OV - Ovarian serous cystadenocarcinoma(117;0.0148)|Lung(94;0.0189)|LUSC - Lung squamous cell carcinoma(192;0.0548)		GAAGAAAGTTCCAGCTCAAGA	0.408		NA											7	20					0	0	0	0
MTUS2	23281	broad.mit.edu	37	13	29599371	29599371	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr13:29599371G>C	uc001usl.3	+	1	624	c.566G>C	c.(565-567)AGA>ACA	p.R189T		NM_001033602	NP_001028774	Q5JR59	MTUS2_HUMAN	hypothetical protein LOC23281 isoform a	179						cytoplasm|microtubule	microtubule binding|protein homodimerization activity				0						TCTTTGGAAAGAGCAAGCAGC	0.547		NA											22	42					0	0	0	0
KL	9365	broad.mit.edu	37	13	33627907	33627907	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr13:33627907C>T	uc001uus.2	+	2	831	c.823C>T	c.(823-825)CAT>TAT	p.H275Y	KL_uc001uur.1_5'UTR	NM_004795	NP_004786	Q9UEF7	KLOT_HUMAN	klotho precursor	275	Glycosyl hydrolase-1 1.|Extracellular (Potential).				aging|carbohydrate metabolic process|insulin receptor signaling pathway|positive regulation of bone mineralization	extracellular space|extracellular space|integral to membrane|integral to plasma membrane|membrane fraction|soluble fraction	beta-glucosidase activity|beta-glucuronidase activity|cation binding|fibroblast growth factor binding|hormone activity|signal transducer activity|vitamin D binding			large_intestine(1)|ovary(1)|skin(1)	3	all_epithelial(80;0.133)	Ovarian(182;1.78e-06)|Breast(139;4.08e-05)|Hepatocellular(188;0.00886)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;7.13e-230)|all cancers(112;1.33e-165)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-113)|Epithelial(112;3.79e-112)|Lung(94;8.52e-27)|LUSC - Lung squamous cell carcinoma(192;1.4e-13)|Kidney(163;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(186;5.63e-08)|BRCA - Breast invasive adenocarcinoma(63;1.41e-05)		TTCATAGGCTCATGCCAAAGT	0.413		NA											19	49					0	0	0	0
KL	9365	broad.mit.edu	37	13	33638296	33638296	+	Silent	SNP	G	G	A	rs139874106		TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr13:33638296G>A	uc001uus.2	+	5	3020	c.3012G>A	c.(3010-3012)TCG>TCA	p.S1004S		NM_004795	NP_004786	Q9UEF7	KLOT_HUMAN	klotho precursor	1004	Cytoplasmic (Potential).				aging|carbohydrate metabolic process|insulin receptor signaling pathway|positive regulation of bone mineralization	extracellular space|extracellular space|integral to membrane|integral to plasma membrane|membrane fraction|soluble fraction	beta-glucosidase activity|beta-glucuronidase activity|cation binding|fibroblast growth factor binding|hormone activity|signal transducer activity|vitamin D binding			large_intestine(1)|ovary(1)|skin(1)	3	all_epithelial(80;0.133)	Ovarian(182;1.78e-06)|Breast(139;4.08e-05)|Hepatocellular(188;0.00886)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;7.13e-230)|all cancers(112;1.33e-165)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-113)|Epithelial(112;3.79e-112)|Lung(94;8.52e-27)|LUSC - Lung squamous cell carcinoma(192;1.4e-13)|Kidney(163;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(186;5.63e-08)|BRCA - Breast invasive adenocarcinoma(63;1.41e-05)		TTTACTACTCGAAGAAAGGCA	0.333		NA											9	14					0	0	0	0
RBM26	64062	broad.mit.edu	37	13	79911235	79911235	+	Splice_Site	SNP	A	A	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr13:79911235A>G	uc001vkz.2	-	19	2753	c.2739_splice	c.e19+1	p.A913_splice	RBM26_uc001vky.2_Splice_Site_p.A884_splice|RBM26_uc001vla.2_Splice_Site_p.A887_splice|RBM26_uc010tia.1_Splice_Site_p.A268_splice|RBM26_uc001vkx.2_Splice_Site_p.A623_splice	NM_022118	NP_071401	Q5T8P6	RBM26_HUMAN	RNA binding motif protein 26						mRNA processing		nucleotide binding|protein binding|RNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(28;0.0279)		GBM - Glioblastoma multiforme(99;0.0188)		GTAAGAAAGTACCGCAAAATG	0.413		NA											9	3					0	0	0	0
MYO16	23026	broad.mit.edu	37	13	109540724	109540724	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr13:109540724G>C	uc001vqt.1	+	14	1618	c.1492G>C	c.(1492-1494)GAA>CAA	p.E498Q	MYO16_uc010agk.1_Missense_Mutation_p.E520Q|MYO16_uc001vqu.1_Missense_Mutation_p.E298Q|MYO16_uc010tjh.1_Missense_Mutation_p.E10Q	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	498	Myosin head-like 1.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			CCTTAGTGGAGAAAGGGGATC	0.438		NA											34	14					0	0	0	0
OR4K5	79317	broad.mit.edu	37	14	20388770	20388770	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr14:20388770A>G	uc010tkw.1	+	1	5	c.5A>G	c.(4-6)GAT>GGT	p.D2G		NM_001005483	NP_001005483	Q8NGD3	OR4K5_HUMAN	olfactory receptor, family 4, subfamily K,	2	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GGAACCATGGATAAGTCCAAT	0.353		NA											8	41					0	0	0	0
G2E3	55632	broad.mit.edu	37	14	31081542	31081542	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr14:31081542C>G	uc001wqk.2	+	13	1784	c.1630C>G	c.(1630-1632)CTT>GTT	p.L544V	G2E3_uc010tpf.1_Missense_Mutation_p.L498V|G2E3_uc001wql.1_Missense_Mutation_p.L56V	NM_017769	NP_060239	Q7L622	G2E3_HUMAN	G2/M-phase specific E3 ubiquitin ligase	544	HECT.				apoptosis|multicellular organismal development|protein modification process	Golgi apparatus|nucleolus	acid-amino acid ligase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3						AAAAGACATACTTGGCTACCA	0.299		NA											20	46					0	0	0	0
STRN3	29966	broad.mit.edu	37	14	31405711	31405711	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr14:31405711T>C	uc001wqu.2	-	6	1052	c.836A>G	c.(835-837)AAT>AGT	p.N279S	STRN3_uc001wqv.2_Missense_Mutation_p.N279S|STRN3_uc010tpj.1_RNA	NM_001083893	NP_001077362	Q13033	STRN3_HUMAN	nuclear autoantigen isoform 1	279					negative regulation of estrogen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|response to estradiol stimulus	cytoplasm|dendrite|Golgi apparatus|neuronal cell body|nucleoplasm|nucleus|plasma membrane|protein complex	armadillo repeat domain binding|calmodulin binding|protein complex binding|protein phosphatase 2A binding|sequence-specific DNA binding transcription factor activity				0	Hepatocellular(127;0.0877)|Breast(36;0.148)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)|BRCA - Breast invasive adenocarcinoma(188;0.0805)	GBM - Glioblastoma multiforme(265;0.0124)		TTTATGTTTATTCATCCGATG	0.328		NA											16	27					0	0	0	0
TRIM9	114088	broad.mit.edu	37	14	51561183	51561183	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr14:51561183G>A	uc001wyx.3	-	1	1240	c.475C>T	c.(475-477)CAG>TAG	p.Q159*	TRIM9_uc001wyy.2_Nonsense_Mutation_p.Q159*|TRIM9_uc001wyz.3_Nonsense_Mutation_p.Q159*	NM_015163	NP_055978	Q9C026	TRIM9_HUMAN	tripartite motif protein 9 isoform 1	159					proteasomal ubiquitin-dependent protein catabolic process	cell junction|cytoskeleton|dendrite|synaptic vesicle	protein homodimerization activity|ubiquitin-protein ligase activity|zinc ion binding			skin(2)|lung(1)	3	all_epithelial(31;0.00418)|Breast(41;0.148)					TTGCTCTGCTGGTAGCGGTCA	0.617		NA											11	28					0	0	0	0
RHOJ	57381	broad.mit.edu	37	14	63749901	63749901	+	Silent	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr14:63749901C>T	uc001xgb.1	+	4	908	c.465C>T	c.(463-465)CTC>CTT	p.L155L		NM_020663	NP_065714	Q9H4E5	RHOJ_HUMAN	ras homolog gene family, member J precursor	155					actin cytoskeleton organization|regulation of cell shape|regulation of small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding|GTPase activity				0				OV - Ovarian serous cystadenocarcinoma(108;0.00326)|all cancers(60;0.031)|BRCA - Breast invasive adenocarcinoma(234;0.119)		AGAAACCTCTCACTTACGAGC	0.398		NA											17	36					0	0	0	0
SYNE2	23224	broad.mit.edu	37	14	64564771	64564771	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr14:64564771G>C	uc001xgm.2	+	62	12443	c.12213G>C	c.(12211-12213)TTG>TTC	p.L4071F	SYNE2_uc001xgl.2_Missense_Mutation_p.L4071F|SYNE2_uc010apy.2_Missense_Mutation_p.L456F|SYNE2_uc010apx.1_Missense_Mutation_p.L463F|MIR548H-1_hsa-mir-548h-1|MI0006411_5'Flank|SYNE2_uc010apz.1_5'Flank	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	4071	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		ACCAGCATTTGAAGCAAGAAC	0.473		NA											6	73					0	0	0	0
ARG2	384	broad.mit.edu	37	14	68086772	68086772	+	Silent	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr14:68086772G>A	uc001xjs.2	+	1	194	c.78G>A	c.(76-78)GTG>GTA	p.V26V		NM_001172	NP_001163	P78540	ARGI2_HUMAN	arginase 2 precursor	26					arginine metabolic process|nitric oxide biosynthetic process|urea cycle	mitochondrial matrix	arginase activity|metal ion binding				0				all cancers(60;0.000582)|OV - Ovarian serous cystadenocarcinoma(108;0.00392)|BRCA - Breast invasive adenocarcinoma(234;0.00928)	L-Arginine(DB00125)|L-Ornithine(DB00129)	TCCACTCCGTGGCTGTGATAG	0.622		NA											8	15					0	0	0	0
FCF1	51077	broad.mit.edu	37	14	75181623	75181623	+	Silent	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr14:75181623C>G	uc001xqh.2	+	3	171	c.120C>G	c.(118-120)CCC>CCG	p.P40P	KIAA0317_uc001xqb.2_5'Flank|KIAA0317_uc010tut.1_5'Flank|KIAA0317_uc001xqc.2_5'Flank|KIAA0317_uc001xqd.1_5'Flank|FCF1_uc001xqe.1_RNA|FCF1_uc001xqf.1_Silent_p.P25P|FCF1_uc001xqg.2_RNA|FCF1_uc001xqi.2_RNA	NM_015962	NP_057046	Q9Y324	FCF1_HUMAN	FCF1 small subunit	40					rRNA processing	nucleolus				ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.0037)		AGAAGGATCCCAGCGCATTAA	0.353		NA											5	7					0	0	0	0
DLST	1743	broad.mit.edu	37	14	75359641	75359641	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr14:75359641C>T	uc001xqv.2	+	8	610	c.547C>T	c.(547-549)CAG>TAG	p.Q183*	DLST_uc001xqu.2_Nonsense_Mutation_p.Q95*|DLST_uc001xqt.2_Nonsense_Mutation_p.Q99*|DLST_uc010tuw.1_Nonsense_Mutation_p.Q97*|DLST_uc001xqs.2_RNA|DLST_uc010tuv.1_Nonsense_Mutation_p.Q183*	NM_001933	NP_001924	P36957	ODO2_HUMAN	dihydrolipoamide S-succinyltransferase (E2	183					lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleus	dihydrolipoyllysine-residue succinyltransferase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00698)		CATACCCACTCAGATGCCACC	0.587		NA											18	21					0	0	0	0
DLST	1743	broad.mit.edu	37	14	75361017	75361017	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr14:75361017G>C	uc001xqv.2	+	10	738	c.675G>C	c.(673-675)GAG>GAC	p.E225D	DLST_uc001xqu.2_Missense_Mutation_p.E137D|DLST_uc001xqt.2_Missense_Mutation_p.E141D|DLST_uc010tuw.1_Missense_Mutation_p.E139D|DLST_uc001xqs.2_RNA|DLST_uc010tuv.1_Missense_Mutation_p.E225D	NM_001933	NP_001924	P36957	ODO2_HUMAN	dihydrolipoamide S-succinyltransferase (E2	225					lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleus	dihydrolipoyllysine-residue succinyltransferase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00698)		ACTTTCAGGAGAAAATGAACA	0.473		NA											47	83					0	0	0	0
C14orf118	55668	broad.mit.edu	37	14	76621245	76621245	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr14:76621245C>G	uc001xsh.2	+	2	625	c.539C>G	c.(538-540)TCA>TGA	p.S180*	C14orf118_uc001xsi.2_Nonsense_Mutation_p.S180*|C14orf118_uc001xsj.1_Nonsense_Mutation_p.S180*|C14orf118_uc001xsk.1_Nonsense_Mutation_p.S180*|C14orf118_uc001xsl.2_RNA	NM_017926	NP_060396	Q9NWQ4	CN118_HUMAN	hypothetical protein LOC55668 isoform 1	180										ovary(2)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.0172)		TGGACCTCATCAGGCCACGGA	0.483		NA											6	19					0	0	0	0
C14orf145	145508	broad.mit.edu	37	14	81209426	81209426	+	Silent	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr14:81209426C>T	uc001xux.2	-	18	2970	c.2799G>A	c.(2797-2799)GAG>GAA	p.E933E	C14orf145_uc010asz.1_RNA	NM_152446	NP_689659	Q6ZU80	CE128_HUMAN	hypothetical protein LOC145508	933	Potential.					centriole|spindle pole					0				BRCA - Breast invasive adenocarcinoma(234;0.0586)		CACCTCTCTTCTCACGATGTA	0.378		NA											18	86					0	0	0	0
SEL1L	6400	broad.mit.edu	37	14	81952776	81952776	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr14:81952776C>T	uc010tvv.1	-	17	1772	c.1655G>A	c.(1654-1656)CGA>CAA	p.R552Q		NM_005065	NP_005056	Q9UBV2	SE1L1_HUMAN	sel-1 suppressor of lin-12-like precursor	552	Lumenal (Potential).|Interaction with ERLEC1, OS9 and SYVN1.|Sel1-like 9.				Notch signaling pathway	endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.0299)		CCAACGGCCTCGTTCACATAC	0.413		NA											34	106					0	0	0	0
SETD3	84193	broad.mit.edu	37	14	99932040	99932040	+	Nonsense_Mutation	SNP	T	T	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr14:99932040T>A	uc001ygc.2	-	2	273	c.103A>T	c.(103-105)AAA>TAA	p.K35*	SETD3_uc001ygd.2_Nonsense_Mutation_p.K35*|SETD3_uc001ygf.2_Nonsense_Mutation_p.K35*	NM_032233	NP_115609	Q86TU7	SETD3_HUMAN	SET domain containing 3 isoform a	35					peptidyl-lysine dimethylation|peptidyl-lysine monomethylation|peptidyl-lysine trimethylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone methyltransferase activity (H3-K36 specific)|transcription coactivator activity				0		all_cancers(154;0.224)|all_epithelial(191;0.0644)|Melanoma(154;0.0866)				GAGGACTTACTCTGCAGCAGC	0.502		NA											9	30					0	0	0	0
EIF5	1983	broad.mit.edu	37	14	103807372	103807372	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr14:103807372G>C	uc001ymq.2	+	12	1801	c.1279G>C	c.(1279-1281)GAT>CAT	p.D427H	EIF5_uc001ymr.2_Missense_Mutation_p.D427H|EIF5_uc001yms.2_Missense_Mutation_p.D427H|EIF5_uc001ymt.2_Missense_Mutation_p.D427H|EIF5_uc001ymu.2_Missense_Mutation_p.D427H	NM_001969	NP_001960	P55010	IF5_HUMAN	eukaryotic translation initiation factor 5	427	Asp-rich (acidic).				regulation of translational initiation|RNA metabolic process	cytosol	GTP binding|GTPase activity|translation initiation factor activity			pancreas(1)|breast(1)|skin(1)	3		Melanoma(154;0.155)	Epithelial(46;0.182)			TGACGACATCGATATTGATGC	0.403		NA											7	42					0	0	0	0
SIVA1	10572	broad.mit.edu	37	14	105225821	105225821	+	Silent	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr14:105225821G>A	uc001yph.2	+	4	596	c.527G>A	c.(526-528)TGA>TAA	p.*176*	INF2_uc010tyi.1_Intron|SIVA1_uc001ypg.1_3'UTR|SIVA1_uc001ypi.2_Silent_p.*111*	NM_006427	NP_006418	O15304	SIVA_HUMAN	CD27-binding (Siva) protein isoform 1	176					activation of caspase activity by cytochrome c|activation-induced cell death of T cells|apoptosis|induction of apoptosis|interspecies interaction between organisms|negative regulation of anti-apoptosis|negative regulation of NF-kappaB transcription factor activity	cytoplasm|mitochondrion|nucleoplasm|nucleus	caspase activator activity|CD27 receptor binding|metal ion binding|viral receptor activity|zinc ion binding				0		all_cancers(154;0.14)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00153)|OV - Ovarian serous cystadenocarcinoma(23;0.0148)|Epithelial(46;0.0396)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.173)		TTCGAGACCTGAGGCTGGCTC	0.597		NA											4	23					0	0	0	0
AKT1	207	broad.mit.edu	37	14	105241317	105241317	+	Silent	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr14:105241317G>A	uc001ypk.2	-	7	1145	c.591C>T	c.(589-591)ACC>ACT	p.T197T	INF2_uc010tyi.1_Intron|AKT1_uc001ypl.2_Silent_p.T197T|AKT1_uc010axa.2_Silent_p.T197T|AKT1_uc001ypm.2_Silent_p.T197T|AKT1_uc001ypn.2_Silent_p.T197T|AKT1_uc010tyk.1_Silent_p.T135T	NM_005163	NP_005154	P31749	AKT1_HUMAN	AKT1 kinase	197	Protein kinase.				activation of pro-apoptotic gene products|activation-induced cell death of T cells|endocrine pancreas development|G-protein coupled receptor protein signaling pathway|glucose metabolic process|glycogen biosynthetic process|induction of apoptosis by intracellular signals|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|mRNA metabolic process|negative regulation of fatty acid beta-oxidation|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of protein kinase activity|nerve growth factor receptor signaling pathway|nitric oxide biosynthetic process|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of blood vessel endothelial cell migration|positive regulation of cell growth|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of establishment of protein localization in plasma membrane|positive regulation of fat cell differentiation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|positive regulation of nitric oxide biosynthetic process|positive regulation of nitric-oxide synthase activity|positive regulation of peptidyl-serine phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|protein autophosphorylation|protein import into nucleus, translocation|regulation of neuron projection development|regulation of translation|response to fluid shear stress|response to heat|response to UV-A|T cell costimulation	cytosol|nucleoplasm|plasma membrane	enzyme binding|identical protein binding|nitric-oxide synthase regulator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|protein serine/threonine kinase activity			breast(86)|urinary_tract(12)|thyroid(10)|lung(7)|endometrium(5)|large_intestine(4)|skin(4)|prostate(3)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|NS(1)	134		all_cancers(154;3.77e-06)|all_lung(585;3.24e-07)|all_epithelial(191;3.45e-05)|all_neural(303;0.0459)|Melanoma(154;0.155)	all cancers(16;0.000486)|OV - Ovarian serous cystadenocarcinoma(23;0.00647)|Epithelial(46;0.0153)|GBM - Glioblastoma multiforme(11;0.116)	all cancers(159;0.0107)|OV - Ovarian serous cystadenocarcinoma(161;0.0132)|Epithelial(152;0.243)	Adenosine triphosphate(DB00171)|Arsenic trioxide(DB01169)	CGCGGTTCTCGGTGAGTGTGT	0.682		1	Mis		breast|colorectal|ovarian|NSCLC								14	56					0	0	0	0
TRPM1	4308	broad.mit.edu	37	15	31339443	31339443	+	Silent	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr15:31339443C>T	uc001zfm.2	-	14	1697	c.1569G>A	c.(1567-1569)CCG>CCA	p.P523P	TRPM1_uc010azy.2_Silent_p.P430P|TRPM1_uc001zfl.2_RNA	NM_002420	NP_002411	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel,	523	Extracellular (Potential).				cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			ovary(2)|pancreas(1)|skin(1)	4		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		GGTAATCAGGCGGAAGGTTGC	0.547		NA											6	25					0	0	0	0
C15orf24	56851	broad.mit.edu	37	15	34382601	34382601	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr15:34382601G>C	uc001zhm.2	-	3	425	c.412C>G	c.(412-414)CTC>GTC	p.L138V	C15orf24_uc001zhn.2_Missense_Mutation_p.L21V	NM_020154	NP_064539	Q9NPA0	CO024_HUMAN	chromosome 15 open reading frame 24 precursor	138	Extracellular (Potential).					cytoplasm|integral to membrane	carbohydrate binding|carboxypeptidase activity|purine nucleotide binding				0		all_lung(180;1.76e-08)		all cancers(64;2.02e-17)|GBM - Glioblastoma multiforme(113;2.15e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)		TTCATTTGGAGAGGATAGGGC	0.393		NA											15	60					0	0	0	0
CASC5	57082	broad.mit.edu	37	15	40914964	40914964	+	Silent	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr15:40914964G>A	uc010bbs.1	+	11	2741	c.2580G>A	c.(2578-2580)CAG>CAA	p.Q860Q	CASC5_uc010ucq.1_Silent_p.Q684Q|CASC5_uc001zme.2_Silent_p.Q834Q|CASC5_uc010bbt.1_Silent_p.Q834Q	NM_170589	NP_733468	Q8NG31	CASC5_HUMAN	cancer susceptibility candidate 5 isoform 1	860	2 X 104 AA approximate repeats.				acrosome assembly|attachment of spindle microtubules to kinetochore|cell division|CenH3-containing nucleosome assembly at centromere|mitotic prometaphase|spindle assembly checkpoint	acrosomal vesicle|condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			breast(3)|central_nervous_system(1)|skin(1)	5		all_cancers(109;2.03e-18)|all_epithelial(112;4.26e-15)|Lung NSC(122;1.12e-10)|all_lung(180;2.59e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;4.99e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0861)|COAD - Colon adenocarcinoma(120;0.211)		AAAGTGTACAGAAACCTAAAT	0.338		NA											32	44					0	0	0	0
SPINT1	6692	broad.mit.edu	37	15	41148218	41148218	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr15:41148218G>A	uc001zna.2	+	9	1498	c.1294G>A	c.(1294-1296)GAG>AAG	p.E432K	SPINT1_uc001znb.2_Missense_Mutation_p.E416K|SPINT1_uc001znc.2_Missense_Mutation_p.E416K|SPINT1_uc010ucs.1_Missense_Mutation_p.E423K	NM_181642	NP_857593	O43278	SPIT1_HUMAN	serine peptidase inhibitor, Kunitz type 1	432	BPTI/Kunitz inhibitor 2.					extracellular region|membrane fraction	protein binding|serine-type endopeptidase inhibitor activity			ovary(1)	1		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;2.91e-05)|COAD - Colon adenocarcinoma(120;0.153)|BRCA - Breast invasive adenocarcinoma(123;0.166)		GAACAACTTTGAGGAAGAGCA	0.577		NA											32	87					0	0	0	0
ZFP106	64397	broad.mit.edu	37	15	42742338	42742338	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr15:42742338G>A	uc001zpw.2	-	2	2398	c.2063C>T	c.(2062-2064)TCT>TTT	p.S688F	ZFP106_uc001zpu.2_5'Flank|ZFP106_uc001zpv.2_Intron|ZFP106_uc001zpx.2_Intron|ZFP106_uc010udh.1_Missense_Mutation_p.S471F|ZFP106_uc001zpy.1_Missense_Mutation_p.S711F	NM_022473	NP_071918	Q9H2Y7	ZF106_HUMAN	zinc finger protein 106 homolog	688						nucleolus	zinc ion binding			central_nervous_system(2)|ovary(1)	3		all_cancers(109;1.63e-12)|all_epithelial(112;3.97e-11)|Lung NSC(122;2.04e-07)|all_lung(180;8.31e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.6e-07)		TGTTTCATAAGATACATGAGA	0.453		NA											34	103					0	0	0	0
SERINC4	619189	broad.mit.edu	37	15	44087395	44087395	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr15:44087395G>T	uc010bds.1	-	9	1096	c.628C>A	c.(628-630)CTG>ATG	p.L210M	ELL3_uc001zsx.1_Intron|SERF2_uc010uee.1_3'UTR|C15orf63_uc001ztb.2_Intron|SERF2_uc001zsz.3_3'UTR|MIR1282_hsa-mir-1282|MI0006429_5'Flank|SERINC4_uc001ztc.1_RNA|SERINC4_uc001ztd.1_Missense_Mutation_p.N97K|SERINC4_uc001zte.1_Missense_Mutation_p.L210M	NM_001033517	NP_001028689	A6NH21	SERC4_HUMAN	serine incorporator 4	454					phospholipid biosynthetic process	integral to membrane					0		all_cancers(109;3.26e-11)|all_epithelial(112;4.82e-09)|Lung NSC(122;1.61e-06)|all_lung(180;1.5e-05)|Melanoma(134;0.0417)		GBM - Glioblastoma multiforme(94;7.81e-07)		GTCTTTTCCAGTTCTGCTCCC	0.507		NA											11	33					2.27e-07	2.41e-07	1	0
SLC30A4	7782	broad.mit.edu	37	15	45778943	45778943	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr15:45778943C>G	uc001zvj.2	-	7	1313	c.1001G>C	c.(1000-1002)GGT>GCT	p.G334A		NM_013309	NP_037441	O14863	ZNT4_HUMAN	solute carrier family 30 (zinc transporter),	334	Cytoplasmic (Potential).				regulation of sequestering of zinc ion|response to toxin	endosome membrane|integral to membrane|late endosome	zinc ion transmembrane transporter activity				0		Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.58e-16)|GBM - Glioblastoma multiforme(94;2.15e-06)		GCTTGGCACACCTATTAGGAA	0.294		NA											41	167					0	0	0	0
TRPM7	54822	broad.mit.edu	37	15	50866575	50866575	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr15:50866575C>G	uc001zyt.3	-	36	5468	c.5204G>C	c.(5203-5205)GGA>GCA	p.G1735A	TRPM7_uc001zyr.2_Missense_Mutation_p.G172A	NM_017672	NP_060142	Q96QT4	TRPM7_HUMAN	transient receptor potential cation channel,	1735	Cytoplasmic (Potential).|Alpha-type protein kinase.				cell death	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein serine/threonine kinase activity			ovary(4)|stomach(3)|breast(1)|central_nervous_system(1)|skin(1)	10				all cancers(107;0.000819)|GBM - Glioblastoma multiforme(94;0.0045)		AATCTCATCTCCATTATTATT	0.388		NA											10	43					0	0	0	0
TRPM7	54822	broad.mit.edu	37	15	50866605	50866605	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr15:50866605C>G	uc001zyt.3	-	36	5438	c.5174G>C	c.(5173-5175)GGA>GCA	p.G1725A	TRPM7_uc001zyr.2_Missense_Mutation_p.G162A	NM_017672	NP_060142	Q96QT4	TRPM7_HUMAN	transient receptor potential cation channel,	1725	Cytoplasmic (Potential).|Alpha-type protein kinase.				cell death	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein serine/threonine kinase activity			ovary(4)|stomach(3)|breast(1)|central_nervous_system(1)|skin(1)	10				all cancers(107;0.000819)|GBM - Glioblastoma multiforme(94;0.0045)		TCTAAATTCTCCAGTCATACA	0.343		NA											4	31					0	0	0	0
DMXL2	23312	broad.mit.edu	37	15	51778300	51778300	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr15:51778300G>C	uc002abf.2	-	23	5677	c.5452C>G	c.(5452-5454)CAA>GAA	p.Q1818E	DMXL2_uc010ufy.1_Missense_Mutation_p.Q1818E|DMXL2_uc010bfa.2_Missense_Mutation_p.Q1182E	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	1818						cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		TTTGGTGTTTGTTCCAGTAAT	0.383		NA											30	27					0	0	0	0
UNC13C	440279	broad.mit.edu	37	15	54305292	54305292	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr15:54305292G>T	uc002ack.2	+	1	192	c.192G>T	c.(190-192)AAG>AAT	p.K64N		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	64					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		GCACTGTAAAGAAGATTGCAA	0.423		NA											9	47					0.00448238	0.00458425	1	0
UNC13C	440279	broad.mit.edu	37	15	54586136	54586136	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr15:54586136G>A	uc002ack.2	+	9	3862	c.3862G>A	c.(3862-3864)GAT>AAT	p.D1288N	UNC13C_uc002acl.2_Missense_Mutation_p.D118N	NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	1288	C2 1.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		CAGAGTATGGGATGAAGATGA	0.358		NA											31	29					0	0	0	0
CILP	8483	broad.mit.edu	37	15	65489097	65489097	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr15:65489097C>T	uc002aon.2	-	9	3708	c.3527G>A	c.(3526-3528)AGA>AAA	p.R1176K		NM_003613	NP_003604	O75339	CILP1_HUMAN	cartilage intermediate layer protein	1176					negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				ovary(4)|pancreas(2)|skin(1)	7						TTGAGCAACTCTAGGAAATCT	0.557		NA											14	30					0	0	0	0
KIF23	9493	broad.mit.edu	37	15	69739225	69739225	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr15:69739225G>A	uc002asb.2	+	22	2929	c.2812G>A	c.(2812-2814)GAG>AAG	p.E938K	KIF23_uc002asc.2_Missense_Mutation_p.E834K|KIF23_uc010bii.2_Missense_Mutation_p.E744K|KIF23_uc010ukc.1_Missense_Mutation_p.E651K	NM_138555	NP_612565	Q02241	KIF23_HUMAN	kinesin family member 23 isoform 1	938					blood coagulation|cytokinesis|microtubule-based movement|mitosis|mitotic spindle elongation	cytosol|kinesin complex|microtubule|midbody|nucleoplasm|spindle	ATP binding|microtubule motor activity|protein binding				0						TGTGGCTGTGGAGATGAGAGC	0.468		NA											13	70					0	0	0	0
GOLGA6B	55889	broad.mit.edu	37	15	72953676	72953676	+	Silent	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr15:72953676C>T	uc010uks.1	+	8	677	c.636C>T	c.(634-636)AAC>AAT	p.N212N		NM_018652	NP_061122	A6NDN3	GOG6B_HUMAN	golgi autoantigen, golgin subfamily a, 6B	212	Potential.										0						CGCTGCTGAACGCACACGTGA	0.582		NA											9	43					0	0	0	0
CSPG4	1464	broad.mit.edu	37	15	75982533	75982533	+	Silent	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr15:75982533G>A	uc002baw.2	-	3	966	c.873C>T	c.(871-873)ATC>ATT	p.I291I		NM_001897	NP_001888	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4 precursor	291	Extracellular (Potential).|Neurite growth inhibition (By similarity).|Globular or compact configuration stabilized by disulfide bonds.|Laminin G-like 2.				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			ovary(2)|pancreas(1)	3						GGTGAGCATTGATGTGGACAC	0.617		NA											12	34					0	0	0	0
ISL2	64843	broad.mit.edu	37	15	76634064	76634064	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr15:76634064C>A	uc002bbw.1	+	6	1046	c.968C>A	c.(967-969)TCC>TAC	p.S323Y		NM_145805	NP_665804	Q96A47	ISL2_HUMAN	ISL LIM homeobox 2	323						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						CCCCAGGTCTCCTTCTCCGAG	0.677		NA											13	66					1.36e-06	1.44e-06	1	0
RASGRF1	5923	broad.mit.edu	37	15	79294085	79294085	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr15:79294085G>A	uc002beq.2	-	17	2917	c.2542C>T	c.(2542-2544)CAG>TAG	p.Q848*	RASGRF1_uc002bep.2_Nonsense_Mutation_p.Q832*|RASGRF1_uc010blm.1_Nonsense_Mutation_p.Q757*|RASGRF1_uc002ber.3_Nonsense_Mutation_p.Q832*|RASGRF1_uc010unh.1_Nonsense_Mutation_p.Q243*|RASGRF1_uc002beo.2_Nonsense_Mutation_p.Q64*	NM_002891	NP_002882	Q13972	RGRF1_HUMAN	Ras protein-specific guanine	850					activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			skin(4)|ovary(1)|central_nervous_system(1)	6						TCATCACTCTGGTTTTGATCA	0.308		NA											47	58					0	0	0	0
ST8SIA2	8128	broad.mit.edu	37	15	93007381	93007381	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr15:93007381G>C	uc002bra.2	+	6	1049	c.894G>C	c.(892-894)TTG>TTC	p.L298F	ST8SIA2_uc002brb.2_Missense_Mutation_p.L277F	NM_006011	NP_006002	Q92186	SIA8B_HUMAN	ST8 alpha-N-acetyl-neuraminide	298	Lumenal (Potential).				axon guidance|N-glycan processing|oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity				0	Lung NSC(78;0.0893)|all_lung(78;0.125)		BRCA - Breast invasive adenocarcinoma(143;0.0355)|OV - Ovarian serous cystadenocarcinoma(32;0.203)			CCGGCCTCTTGATGTATACCC	0.428		NA											3	14					0	0	0	0
RUNDC2A	84127	broad.mit.edu	37	16	12145835	12145835	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr16:12145835G>A	uc002dbw.1	+	8	942	c.880G>A	c.(880-882)GAC>AAC	p.D294N	SNX29_uc002dby.3_5'Flank	NM_032167	NP_115543	Q9HA26	RUN2A_HUMAN	RUN domain containing 2A	294										ovary(1)	1						GAGCTCAGAGGACAACTCCGA	0.483		NA	T	CIITA	PMBL|Hodgkin Lymphona|								15	52					0	0	0	0
MYH11	4629	broad.mit.edu	37	16	15833949	15833949	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr16:15833949C>T	uc002ddy.2	-	23	3063	c.2956G>A	c.(2956-2958)GAG>AAG	p.E986K	MYH11_uc002ddv.2_Missense_Mutation_p.E993K|MYH11_uc002ddw.2_Missense_Mutation_p.E986K|MYH11_uc002ddx.2_Missense_Mutation_p.E993K|MYH11_uc010bvg.2_Missense_Mutation_p.E818K	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	986	Potential.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						ACCAGGATCTCATCCTCCAGT	0.363		NA	T	CBFB	AML								28	78					0	0	0	0
MYH11	4629	broad.mit.edu	37	16	15841954	15841954	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr16:15841954G>C	uc002ddy.2	-	17	2237	c.2130C>G	c.(2128-2130)ATC>ATG	p.I710M	MYH11_uc002ddv.2_Missense_Mutation_p.I717M|MYH11_uc002ddw.2_Missense_Mutation_p.I710M|MYH11_uc002ddx.2_Missense_Mutation_p.I717M|MYH11_uc010bvg.2_Missense_Mutation_p.I542M	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	710	Myosin head-like.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						CCTGCCGGCAGATGCGAATGC	0.637		NA	T	CBFB	AML								15	64					0	0	0	0
XYLT1	64131	broad.mit.edu	37	16	17221547	17221547	+	Silent	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr16:17221547G>A	uc002dfa.2	-	10	2284	c.2199C>T	c.(2197-2199)GAC>GAT	p.D733D		NM_022166	NP_071449	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	733	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			ovary(4)	4						GCCTCCCAAAGTCACTGGGTG	0.483		NA											114	93					0	0	0	0
CDH8	1006	broad.mit.edu	37	16	61935158	61935158	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr16:61935158G>A	uc002eog.1	-	3	724	c.472C>T	c.(472-474)CAA>TAA	p.Q158*		NM_001796	NP_001787	P55286	CADH8_HUMAN	cadherin 8, type 2 preproprotein	158	Extracellular (Potential).|Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|skin(2)|breast(1)	9		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		TTGATGTCTTGAACTTTAATA	0.433		NA											19	62					0	0	0	0
HYDIN	54768	broad.mit.edu	37	16	71212846	71212846	+	Silent	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr16:71212846C>T	uc002ezr.2	-	4	494	c.366G>A	c.(364-366)TTG>TTA	p.L122L	HYDIN_uc010cfz.1_5'UTR|HYDIN_uc002ezv.2_Silent_p.L122L|HYDIN_uc010vmc.1_Silent_p.L139L|HYDIN_uc010vmd.1_Silent_p.L149L|HYDIN_uc002ezw.3_Silent_p.L139L	NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	122										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				CATTGTTCCTCAAAATCAGTG	0.403		NA											29	89					0	0	0	0
TAT	6898	broad.mit.edu	37	16	71609874	71609874	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr16:71609874C>G	uc002fap.2	-	3	390	c.291G>C	c.(289-291)ATG>ATC	p.M97I	TAT_uc002faq.2_Missense_Mutation_p.M97I|TAT_uc002far.2_3'UTR	NM_000353	NP_000344	P17735	ATTY_HUMAN	tyrosine aminotransferase	97					2-oxoglutarate metabolic process|glutamate metabolic process|L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	1-aminocyclopropane-1-carboxylate synthase activity|L-tyrosine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			ovary(2)	2		Ovarian(137;0.125)		Kidney(780;0.0157)	L-Glutamic Acid(DB00142)|L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Pyridoxal Phosphate(DB00114)	GGGCATCTTTCATTGCCTGGG	0.488		NA											20	87					0	0	0	0
GLG1	2734	broad.mit.edu	37	16	74527006	74527006	+	Silent	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr16:74527006C>G	uc002fcy.3	-	7	1133	c.1083G>C	c.(1081-1083)CTG>CTC	p.L361L	GLG1_uc002fcx.2_Silent_p.L361L|GLG1_uc002fcw.3_Silent_p.L350L|GLG1_uc002fcz.3_Intron	NM_001145667	NP_001139139	Q92896	GSLG1_HUMAN	golgi apparatus protein 1 isoform 3	361	Cys-rich GLG1 5.|Extracellular (Potential).					Golgi membrane|integral to membrane	receptor binding			ovary(1)|breast(1)	2						CCTGGGCAATCAGCTTTTGGC	0.453		NA											22	62					0	0	0	0
MBTPS1	8720	broad.mit.edu	37	16	84089658	84089658	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr16:84089658C>T	uc002fhi.2	-	22	3416	c.2914G>A	c.(2914-2916)GTG>ATG	p.V972M	MBTPS1_uc002fhh.2_Missense_Mutation_p.V476M	NM_003791	NP_003782	Q14703	MBTP1_HUMAN	membrane-bound transcription factor site-1	972	Lumenal (Potential).				cholesterol metabolic process|proteolysis	endoplasmic reticulum lumen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	serine-type endopeptidase activity			ovary(2)	2						AAGGGCCTCACTTGAGGGCGA	0.498		NA											40	32					0	0	0	0
MYBBP1A	10514	broad.mit.edu	37	17	4455427	4455427	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr17:4455427G>A	uc002fyb.3	-	7	960	c.898C>T	c.(898-900)CCA>TCA	p.P300S	MYBBP1A_uc002fxz.3_Missense_Mutation_p.P300S	NM_014520	NP_055335	Q9BQG0	MBB1A_HUMAN	MYB binding protein 1a isoform 2	300	Interaction with MYB (By similarity).				nucleocytoplasmic transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NLS-dependent protein nuclear import complex|nucleolus	DNA binding|DNA-directed DNA polymerase activity|transcription factor binding			ovary(1)|skin(1)	2						CACCTGGCTGGCCAGAACTGC	0.627		NA											4	69					0	0	0	0
SLC13A5	284111	broad.mit.edu	37	17	6606428	6606428	+	Silent	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr17:6606428G>A	uc002gdj.2	-	5	665	c.577C>T	c.(577-579)CTG>TTG	p.L193L	SLC13A5_uc010vtf.1_Silent_p.L193L|SLC13A5_uc010clq.2_Silent_p.L150L|SLC13A5_uc002gdk.2_Silent_p.L176L|SLC13A5_uc002gdl.1_Silent_p.L175L	NM_177550	NP_808218	Q86YT5	S13A5_HUMAN	solute carrier family 13, member 5 isoform a	193						integral to membrane	citrate transmembrane transporter activity				0						TGCTGCCCCAGAGTGGGGCCT	0.632		NA											25	77					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7577106	7577106	+	Missense_Mutation	SNP	G	G	A	rs17849781		TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr17:7577106G>A	uc002gim.2	-	8	1026	c.832C>T	c.(832-834)CCT>TCT	p.P278S	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.P278S|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.P146S|TP53_uc010cng.1_Missense_Mutation_p.P146S|TP53_uc002gii.1_Missense_Mutation_p.P146S|TP53_uc010cnh.1_Missense_Mutation_p.P278S|TP53_uc010cni.1_Missense_Mutation_p.P278S|TP53_uc002gij.2_Missense_Mutation_p.P278S	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	278	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		P -> F (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|P -> S (in LFS; germline mutation and in sporadic cancers; somatic mutation).|P -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|P -> H (in sporadic cancers; somatic mutation).|P -> R (in sporadic cancers; somatic mutation).|P -> T (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.P278L(52)|p.P278S(48)|p.P278R(26)|p.P278T(21)|p.P278A(18)|p.P278H(11)|p.0?(7)|p.P278fs*67(5)|p.P278F(3)|p.P278fs*28(2)|p.?(2)|p.A276_R283delACPGRDRR(1)|p.A276fs*64(1)|p.V274_P278del(1)|p.P278P(1)|p.C277_P278insXXXXXXX(1)|p.F270_D281del12(1)|p.P278_G279insXXXXX(1)|p.C275_R283delCACPGRDRR(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.C275fs*67(1)|p.V272_K292del21(1)|p.C275fs*20(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCTCTCCCAGGACAGGCACAA	0.552		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			9	32					0	0	0	0
GUCY2D	3000	broad.mit.edu	37	17	7907263	7907263	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr17:7907263C>T	uc002gjt.2	+	3	889	c.815C>T	c.(814-816)TCC>TTC	p.S272F		NM_000180	NP_000171	Q02846	GUC2D_HUMAN	guanylate cyclase 2D, membrane (retina-specific)	272	Extracellular (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			skin(1)	1		Prostate(122;0.157)				ACCGATGGCTCCCTGGTCTTC	0.672		NA											29	96					0	0	0	0
KRT34	3885	broad.mit.edu	37	17	39538614	39538614	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr17:39538614G>A	uc002hwm.2	-	1	23	c.11C>T	c.(10-12)GCC>GTC	p.A4V		NM_021013	NP_066293	O76011	KRT34_HUMAN	keratin 34	4	Head.				epidermis development	intermediate filament	protein binding|structural molecule activity			central_nervous_system(1)	1		Breast(137;0.000496)				TGGGGGCTTGGCATACAGCAT	0.433		NA											16	15					0	0	0	0
WNT3	7473	broad.mit.edu	37	17	44851102	44851102	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr17:44851102C>T	uc002ikv.2	-	2	373	c.254G>A	c.(253-255)CGG>CAG	p.R85Q		NM_030753	NP_110380	P56703	WNT3_HUMAN	wingless-type MMTV integration site family,	85					canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|cellular response to retinoic acid|dorsal/ventral axis specification|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic pattern specification|head morphogenesis|hemopoietic stem cell proliferation|inner ear morphogenesis|limb bud formation|mammary gland epithelium development|mesoderm formation|midbrain-hindbrain boundary development|negative regulation of fat cell differentiation|positive regulation of cell proliferation|Spemann organizer formation at the anterior end of the primitive streak|Wnt receptor signaling pathway, calcium modulating pathway	early endosome|extracellular space|late endosome|membrane fraction|membrane raft|plasma membrane|proteinaceous extracellular matrix	frizzled binding|frizzled-2 binding|signal transducer activity			lung(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.0257)			GCGGCGGCCCCGGAACTGGTG	0.647		NA											34	16					0	0	0	0
RAD51C	5889	broad.mit.edu	37	17	56770070	56770070	+	Silent	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr17:56770070G>A	uc002iwu.2	+	1	108	c.66G>A	c.(64-66)GCG>GCA	p.A22A	TEX14_uc002iwr.1_5'Flank|TEX14_uc002iws.1_5'Flank|TEX14_uc010dcz.1_5'Flank|TEX14_uc010dda.1_5'Flank|TEX14_uc010wnz.1_5'Flank|RAD51C_uc002iwt.1_Silent_p.A22A|RAD51C_uc010woa.1_Silent_p.A22A|RAD51C_uc010ddc.2_RNA|RAD51C_uc002iwv.2_RNA|RAD51C_uc002iww.2_RNA|RAD51C_uc010wob.1_Intron	NM_058216	NP_478123	O43502	RA51C_HUMAN	RAD51 homolog C isoform 1	22					blood coagulation|DNA repair	mitochondrion|nucleoplasm|perinuclear region of cytoplasm	ATP binding|DNA binding|DNA-dependent ATPase activity				0	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TGTCTCCAGCGGTGCGGGTGA	0.587		NA						Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2				37	16					0	0	0	0
BRIP1	83990	broad.mit.edu	37	17	59761063	59761063	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr17:59761063G>A	uc002izk.1	-	20	3485	c.3344C>T	c.(3343-3345)TCC>TTC	p.S1115F		NM_032043	NP_114432	Q9BX63	FANCJ_HUMAN	BRCA1 interacting protein C-terminal helicase 1	1115					DNA damage checkpoint|double-strand break repair|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			ovary(1)	1						ATTTGAAGTGGACTGTTTATC	0.353		NA	F|N|Mis			AML|leukemia|breast		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				44	17					0	0	0	0
RAB31	11031	broad.mit.edu	37	18	9708423	9708423	+	Silent	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr18:9708423C>G	uc002kog.2	+	1	196	c.21C>G	c.(19-21)CTC>CTG	p.L7L		NM_006868	NP_006859	Q13636	RAB31_HUMAN	RAB31, member RAS oncogene family	6					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			skin(1)	1						TACGGGAGCTCAAAGTGTGCC	0.592		NA											4	18					0	0	0	0
POTEC	388468	broad.mit.edu	37	18	14513720	14513720	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr18:14513720C>T	uc010dln.2	-	10	1928	c.1474G>A	c.(1474-1476)GAG>AAG	p.E492K	POTEC_uc010xaj.1_RNA	NM_001137671	NP_001131143	B2RU33	POTEC_HUMAN	ANKRD26-like family B, member 2	492	Potential.									skin(3)	3						GTCAGAATCTCATCTTGTGAT	0.313		NA											4	36					0	0	0	0
ANKRD30B	374860	broad.mit.edu	37	18	14851748	14851748	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr18:14851748G>C	uc010dlo.2	+	36	3628	c.3448G>C	c.(3448-3450)GTT>CTT	p.V1150L	ANKRD30B_uc010xal.1_Missense_Mutation_p.V292L	NM_001145029	NP_001138501	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	1235	Potential.									ovary(1)|skin(1)	2						GCAGCTTAAAGTTCTGACGGC	0.373		NA											12	10					0	0	0	0
CDH2	1000	broad.mit.edu	37	18	25568547	25568547	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr18:25568547C>T	uc002kwg.2	-	11	2141	c.1682G>A	c.(1681-1683)CGA>CAA	p.R561Q	CDH2_uc010xbn.1_Missense_Mutation_p.R530Q	NM_001792	NP_001783	P19022	CADH2_HUMAN	cadherin 2, type 1 preproprotein	561	Extracellular (Potential).|Cadherin 4.				adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			ovary(3)|lung(1)	4						TGGTGATTCTCGGTCCAAAAC	0.333		NA											12	20					0	0	0	0
ASXL3	80816	broad.mit.edu	37	18	31324115	31324115	+	Missense_Mutation	SNP	G	G	C	rs144287211	by1000genomes	TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr18:31324115G>C	uc010dmg.1	+	12	4358	c.4303G>C	c.(4303-4305)GAA>CAA	p.E1435Q	ASXL3_uc002kxq.2_Missense_Mutation_p.E1142Q	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	1435					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						GTTAAGTGCTGAAAGCTTGGA	0.488		NA									OREG0024911	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	37	176					0	0	0	0
MBP	4155	broad.mit.edu	37	18	74729142	74729142	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr18:74729142C>G	uc010xfd.1	-	4	486	c.222G>C	c.(220-222)AAG>AAC	p.K74N	MBP_uc002lml.2_5'Flank|MBP_uc002lmn.2_5'Flank|MBP_uc002lmp.2_5'Flank|MBP_uc010xfe.1_5'UTR|MBP_uc002lmr.2_Missense_Mutation_p.K74N	NM_001025101	NP_001020272	P02686	MBP_HUMAN	Golli-mbp isoform 1	74					central nervous system development|immune response|synaptic transmission	plasma membrane	structural constituent of myelin sheath			haematopoietic_and_lymphoid_tissue(1)	1		Prostate(75;0.0865)|Esophageal squamous(42;0.129)|Melanoma(33;0.211)		OV - Ovarian serous cystadenocarcinoma(15;1.79e-06)|BRCA - Breast invasive adenocarcinoma(31;0.113)|READ - Rectum adenocarcinoma(1;0.188)		GCCAGGCATTCTTCGGGTCCG	0.607		NA											20	9					0	0	0	0
HMHA1	23526	broad.mit.edu	37	19	1085820	1085820	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:1085820G>A	uc002lqz.1	+	23	3457	c.3226G>A	c.(3226-3228)GAG>AAG	p.E1076K	HMHA1_uc010xgd.1_Missense_Mutation_p.E1092K|HMHA1_uc010xge.1_Missense_Mutation_p.E944K|HMHA1_uc002lra.1_Missense_Mutation_p.E916K|HMHA1_uc002lrb.1_Missense_Mutation_p.E959K|HMHA1_uc002lrc.1_Missense_Mutation_p.E711K|HMHA1_uc002lrd.1_Missense_Mutation_p.E152K|HMHA1_uc010dsd.1_Missense_Mutation_p.E182K	NM_012292	NP_036424	Q92619	HMHA1_HUMAN	minor histocompatibility antigen HA-1	1076					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding			lung(1)	1		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGGCAGTGAGGAGCAGCTGGA	0.672		NA											12	18					0	0	0	0
MEX3D	399664	broad.mit.edu	37	19	1556757	1556757	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:1556757C>T	uc010dsn.2	-	2	761	c.761G>A	c.(760-762)CGC>CAC	p.R254H		NM_203304	NP_976049	Q86XN8	MEX3D_HUMAN	ring finger and KH domain containing 1	254					mRNA destabilization|posttranscriptional regulation of gene expression by mRNA localization|regulation of anti-apoptosis	nucleus|perinuclear region of cytoplasm	AU-rich element binding|zinc ion binding			lung(1)	1		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCCTTGCTGCGCGTGGCGCG	0.706		NA											16	41					0	0	0	0
TIMM13	26517	broad.mit.edu	37	19	2427036	2427036	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:2427036G>C	uc002lvx.1	-	3	542	c.198C>G	c.(196-198)ATC>ATG	p.I66M		NM_012458	NP_036590	Q9Y5L4	TIM13_HUMAN	translocase of inner mitochondrial membrane 13	66	Twin CX3C motif.				protein import into mitochondrial inner membrane|sensory perception of sound|transmembrane transport	mitochondrial inner membrane presequence translocase complex|mitochondrial intermembrane space protein transporter complex	protein binding|zinc ion binding				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGCACATGGCGATGCACTTCT	0.706		NA											5	7					0	0	0	0
ZNF555	148254	broad.mit.edu	37	19	2853240	2853240	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:2853240G>C	uc002lwo.2	+	4	1266	c.1177G>C	c.(1177-1179)GAG>CAG	p.E393Q	ZNF555_uc002lwn.3_Missense_Mutation_p.E392Q	NM_152791	NP_690004	Q8NEP9	ZN555_HUMAN	zinc finger protein 555	393					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCATGGTGGAGAGAAACCCTA	0.493		NA											11	23					0	0	0	0
NCLN	56926	broad.mit.edu	37	19	3192541	3192541	+	Silent	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:3192541C>T	uc002lxi.2	+	2	412	c.258C>T	c.(256-258)CTC>CTT	p.L86L	NCLN_uc002lxh.1_RNA	NM_020170	NP_064555	Q969V3	NCLN_HUMAN	nicalin precursor	86	Lumenal (Potential).				proteolysis|regulation of signal transduction	endoplasmic reticulum membrane|integral to membrane|nucleus	peptidase activity|protein binding				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.83e-113)|Epithelial(107;1.65e-111)|all cancers(105;1.53e-103)|BRCA - Breast invasive adenocarcinoma(158;0.00139)|STAD - Stomach adenocarcinoma(1328;0.18)		GCTGCGTGCTCATGCGGCTAC	0.697		NA											6	18					0	0	0	0
MUC16	94025	broad.mit.edu	37	19	9084208	9084208	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:9084208A>G	uc002mkp.2	-	1	7811	c.7607T>C	c.(7606-7608)ATT>ACT	p.I2536T		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	2536	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGCTGGTTCAATAGTTGATGC	0.507		NA											12	29					0	0	0	0
ZNF560	147741	broad.mit.edu	37	19	9578107	9578107	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:9578107G>C	uc002mlp.1	-	10	1726	c.1516C>G	c.(1516-1518)CAT>GAT	p.H506D	ZNF560_uc010dwr.1_Missense_Mutation_p.H400D	NM_152476	NP_689689	Q96MR9	ZN560_HUMAN	zinc finger protein 560	506	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|large_intestine(1)|pancreas(1)|liver(1)	6						GTTCTCAAATGAGCAAAAAGA	0.413		NA											13	93					0	0	0	0
ZNF433	163059	broad.mit.edu	37	19	12126809	12126809	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:12126809G>C	uc002msy.1	-	4	1044	c.873C>G	c.(871-873)TTC>TTG	p.F291L	uc002msx.1_Intron|ZNF433_uc002msz.1_Missense_Mutation_p.F256L	NM_001080411	NP_001073880	Q8N7K0	ZN433_HUMAN	zinc finger protein 433	291	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GGGAAGAGCTGAAGGCTTTCC	0.433		NA											13	37					0	0	0	0
OR7A10	390892	broad.mit.edu	37	19	14952228	14952228	+	Silent	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:14952228C>G	uc002mzx.1	-	1	462	c.462G>C	c.(460-462)CTG>CTC	p.L154L		NM_001005190	NP_001005190	O76100	OR7AA_HUMAN	olfactory receptor, family 7, subfamily A,	154	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Ovarian(108;0.203)					ACATGGAATTCAGAACACTCA	0.458		NA											4	64					0	0	0	0
NOTCH3	4854	broad.mit.edu	37	19	15291928	15291928	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:15291928G>T	uc002nan.2	-	18	2914	c.2838C>A	c.(2836-2838)TTC>TTA	p.F946L	NOTCH3_uc002nao.1_Missense_Mutation_p.F894L	NM_000435	NP_000426	Q9UM47	NOTC3_HUMAN	Notch homolog 3 precursor	946	Extracellular (Potential).|EGF-like 24.				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			lung(8)|ovary(5)|skin(4)|prostate(2)|central_nervous_system(1)|breast(1)	21			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			acaggcagctgaacgagttca	0.274		NA											4	14					0.00024832	0.000257691	1	0
CPAMD8	27151	broad.mit.edu	37	19	17111256	17111256	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:17111256C>G	uc002nfb.2	-	10	1008	c.976G>C	c.(976-978)GAG>CAG	p.E326Q		NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	279						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						CGTCCCACCTCGTGGCTGTAG	0.517		NA											6	19					0	0	0	0
ZNF100	163227	broad.mit.edu	37	19	21948580	21948580	+	Silent	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:21948580C>T	uc002nqi.2	-	2	211	c.12G>A	c.(10-12)CCG>CCA	p.P4P		NM_173531	NP_775802	Q8IYN0	ZN100_HUMAN	zinc finger protein 100	4					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TTCCATACCTCGGGTCATCCT	0.483		NA											18	46					0	0	0	0
ZNF208	7757	broad.mit.edu	37	19	22156005	22156005	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:22156005A>T	uc002nqp.2	-	5	1680	c.1531T>A	c.(1531-1533)TGT>AGT	p.C511S	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				CATTCTTCACATTTGTAGGGT	0.373		NA											27	23					0	0	0	0
NUDT19	390916	broad.mit.edu	37	19	33200187	33200187	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:33200187G>A	uc010edf.2	+	2	811	c.811G>A	c.(811-813)GCC>ACC	p.A271T		NM_001105570	NP_001099040	A8MXV4	NUD19_HUMAN	nudix (nucleoside diphosphate linked moiety	271						mitochondrion|peroxisome	hydrolase activity|metal ion binding				0	Esophageal squamous(110;0.137)					TGCAAACTTTGCCTCTCTCTC	0.453		NA											52	175					0	0	0	0
RHPN2	85415	broad.mit.edu	37	19	33493179	33493179	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:33493179G>C	uc002nuf.2	-	9	1145	c.1079C>G	c.(1078-1080)ACT>AGT	p.T360S	RHPN2_uc010xro.1_Missense_Mutation_p.T209S|RHPN2_uc002nue.2_Missense_Mutation_p.T90S	NM_033103	NP_149094	Q8IUC4	RHPN2_HUMAN	rhophilin, Rho GTPase binding protein 2	360	BRO1.				signal transduction	perinuclear region of cytoplasm	protein binding			central_nervous_system(5)|ovary(1)	6	Esophageal squamous(110;0.137)					GAGGATGGCAGTGAAGTAGTG	0.647		NA											20	37					0	0	0	0
MAP4K1	11184	broad.mit.edu	37	19	39103307	39103307	+	Silent	SNP	G	G	A	rs56029962		TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:39103307G>A	uc002oix.1	-	9	717	c.609C>T	c.(607-609)ATC>ATT	p.I203I	MAP4K1_uc002oiy.1_Silent_p.I203I|MAP4K1_uc010xug.1_5'UTR	NM_007181	NP_009112	Q92918	M4K1_HUMAN	mitogen-activated protein kinase kinase kinase	203	Protein kinase.				activation of JUN kinase activity|peptidyl-serine phosphorylation		ATP binding|MAP kinase kinase kinase kinase activity|protein binding|small GTPase regulator activity			skin(4)|lung(3)|ovary(1)	8	all_cancers(60;6.42e-06)|Ovarian(47;0.103)		Lung(45;0.000751)|LUSC - Lung squamous cell carcinoma(53;0.00272)			CGATGGCCGTGATGCCCAGGG	0.627		NA											26	70					0	0	0	0
PSG7	5676	broad.mit.edu	37	19	43433864	43433864	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:43433864G>T	uc002ovl.3	-	4	541	c.439C>A	c.(439-441)CCC>ACC	p.P147T	PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_5'Flank|PSG7_uc002out.1_5'UTR|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron|PSG7_uc010xwl.1_Missense_Mutation_p.P25T	NM_002783	NP_002774	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7	147	Ig-like C2-type 1.				female pregnancy	extracellular region					0		Prostate(69;0.00682)				GAGGGTTTGGGAGTCTCCACT	0.512		NA											61	13					1.44e-24	1.56e-24	1	0
IRGC	56269	broad.mit.edu	37	19	44223308	44223308	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:44223308G>A	uc002oxh.2	+	2	745	c.598G>A	c.(598-600)GAG>AAG	p.E200K		NM_019612	NP_062558	Q6NXR0	IIGP5_HUMAN	immunity-related GTPase family, cinema	200						membrane	GTP binding|hydrolase activity, acting on acid anhydrides			ovary(1)|central_nervous_system(1)|skin(1)	3		Prostate(69;0.0435)				CCACTGTGCCGAGCGGCTGCG	0.701		NA											14	54					0	0	0	0
ZFP112	7771	broad.mit.edu	37	19	44831903	44831903	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:44831903G>A	uc010ejj.2	-	5	2538	c.2425C>T	c.(2425-2427)CAG>TAG	p.Q809*	ZFP112_uc002ozc.3_Nonsense_Mutation_p.Q803*|ZFP112_uc010xwy.1_Nonsense_Mutation_p.Q826*|ZFP112_uc010xwz.1_Nonsense_Mutation_p.Q808*	NM_001083335	NP_001076804	Q9UJU3	ZF112_HUMAN	zinc finger protein 228 isoform 1	809	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)	5						TTACCACACTGTTCACATTTA	0.458		NA											37	100					0	0	0	0
CKM	1158	broad.mit.edu	37	19	45818846	45818846	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:45818846C>A	uc002pbd.2	-	4	432	c.358G>T	c.(358-360)GAC>TAC	p.D120Y		NM_001824	NP_001815	P06732	KCRM_HUMAN	muscle creatine kinase	120					creatine metabolic process	cytosol	ATP binding|creatine kinase activity			skin(1)	1		Ovarian(192;0.0336)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;2.29e-44)|Epithelial(262;1.05e-38)|GBM - Glioblastoma multiforme(486;3.56e-07)	Creatine(DB00148)	GGGTCCAGGTCGTCTCCACCC	0.677		NA											10	25					2.18e-05	2.28e-05	1	0
DBP	1628	broad.mit.edu	37	19	49140149	49140149	+	Silent	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:49140149G>A	uc002pjx.3	-	1	491	c.103C>T	c.(103-105)CTG>TTG	p.L35L	SEC1_uc010xzv.1_5'Flank|SEC1_uc002pka.2_5'Flank|SEC1_uc010xzw.1_5'Flank|SEC1_uc010ema.2_5'Flank|DBP_uc002pjy.2_Silent_p.L35L|DBP_uc010elz.1_Silent_p.L35L	NM_001352	NP_001343	Q10586	DBP_HUMAN	D site of albumin promoter (albumin D-box)	35					regulation of transcription from RNA polymerase II promoter|rhythmic process	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_lung(116;0.000125)|Lung NSC(112;0.000202)|all_epithelial(76;0.000283)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;9.98e-05)|all cancers(93;0.000112)|GBM - Glioblastoma multiforme(486;0.00615)|Epithelial(262;0.0155)		GTCCCCTGCAGAAGGCTCCGC	0.701		NA											3	10					0	0	0	0
GYS1	2997	broad.mit.edu	37	19	49484831	49484831	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:49484831G>T	uc002plp.2	-	8	1366	c.1125C>A	c.(1123-1125)TTC>TTA	p.F375L	GYS1_uc010xzy.1_Missense_Mutation_p.F8L|GYS1_uc010emm.2_Missense_Mutation_p.F311L|GYS1_uc010xzz.1_Missense_Mutation_p.F295L|GYS1_uc010yaa.1_RNA	NM_002103	NP_002094	P13807	GYS1_HUMAN	glycogen synthase 1 (muscle) isoform 1	375					glucose metabolic process|glycogen biosynthetic process	cytosol	glycogen (starch) synthase activity|protein binding			ovary(2)	2		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;8.64e-05)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000164)|all cancers(93;0.000226)|GBM - Glioblastoma multiforme(486;0.00561)|Epithelial(262;0.0286)		TTTCCACGTTGAAATTGTTGG	0.587		NA											4	33					0.00198382	0.00203521	1	0
SLC17A7	57030	broad.mit.edu	37	19	49935905	49935905	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:49935905C>T	uc002pnp.2	-	9	1193	c.1021G>A	c.(1021-1023)GGC>AGC	p.G341S	SLC17A7_uc002pno.2_Missense_Mutation_p.G40S	NM_020309	NP_064705	Q9P2U7	VGLU1_HUMAN	solute carrier family 17, member 7	341	Extracellular (Potential).				glutamate secretion|neurotransmitter secretion	cell junction|clathrin sculpted glutamate transport vesicle membrane|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|sodium-dependent phosphate transmembrane transporter activity|sodium:inorganic phosphate symporter activity			ovary(1)|pancreas(1)|skin(1)	3		all_lung(116;1.62e-07)|Lung NSC(112;8.47e-07)|all_neural(266;0.0381)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(486;0.0245)		GACACCAGGCCTACCTGCGGG	0.692		NA											18	13					0	0	0	0
TSKS	60385	broad.mit.edu	37	19	50243129	50243129	+	Silent	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:50243129G>A	uc002ppm.2	-	11	1694	c.1683C>T	c.(1681-1683)CTC>CTT	p.L561L		NM_021733	NP_068379	Q9UJT2	TSKS_HUMAN	testis-specific kinase substrate	561							protein binding			large_intestine(1)|skin(1)	2		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		GCAGGTTGCTGAGATGATCGT	0.587		NA											31	75					0	0	0	0
SIGLEC6	946	broad.mit.edu	37	19	52034048	52034048	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:52034048G>A	uc002pwy.2	-	3	755	c.593C>T	c.(592-594)TCG>TTG	p.S198L	SIGLEC6_uc002pwz.2_Missense_Mutation_p.S198L|SIGLEC6_uc002pxa.2_Missense_Mutation_p.S198L|SIGLEC6_uc010ydb.1_Missense_Mutation_p.S151L|SIGLEC6_uc010ydc.1_Missense_Mutation_p.S187L|SIGLEC6_uc010eoz.1_Missense_Mutation_p.S176L|SIGLEC6_uc010epb.1_Missense_Mutation_p.S151L|SIGLEC6_uc010epa.1_Missense_Mutation_p.S187L	NM_001245	NP_001236	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6 isoform 1	198	Ig-like C2-type 1.|Extracellular (Potential).				cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				ovary(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)		TGTGAGCACCGAGGACTGGGT	0.652		NA											19	66					0	0	0	0
HAS1	3036	broad.mit.edu	37	19	52217097	52217097	+	Silent	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:52217097G>A	uc002pxo.1	-	5	1355	c.1320C>T	c.(1318-1320)GGC>GGT	p.G440G	HAS1_uc010epc.1_Silent_p.G40G|HAS1_uc010epd.1_3'UTR|HAS1_uc002pxn.1_Silent_p.G447G|HAS1_uc002pxp.1_Silent_p.G439G	NM_001523	NP_001514	Q92839	HAS1_HUMAN	hyaluronan synthase 1	440	Helical; Name=4; (Potential).				cell adhesion	integral to plasma membrane	hyaluronan synthase activity|protein binding			ovary(1)|pancreas(1)	2		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00102)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		CCAGTGCCACGCCCTGCACGC	0.697		NA											7	13					0	0	0	0
PRKCG	5582	broad.mit.edu	37	19	54409999	54409999	+	Silent	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:54409999G>A	uc002qcq.1	+	18	2226	c.1944G>A	c.(1942-1944)ACG>ACA	p.T648T	PRKCG_uc010yeg.1_Silent_p.T648T|PRKCG_uc010yeh.1_Silent_p.T499T	NM_002739	NP_002730	P05129	KPCG_HUMAN	protein kinase C, gamma	648	AGC-kinase C-terminal.				activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			lung(4)|ovary(2)|pancreas(2)|large_intestine(1)	9	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		AGTTCTTCACGCGGGCGGCGC	0.647		NA									OREG0025667	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	33	90					0	0	0	0
NDUFA3	4696	broad.mit.edu	37	19	54606193	54606193	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:54606193G>A	uc002qde.2	+	1	34	c.7G>A	c.(7-9)GCG>ACG	p.A3T	OSCAR_uc002qcy.2_5'Flank|OSCAR_uc002qcz.2_5'Flank|OSCAR_uc002qda.2_5'Flank|OSCAR_uc002qdb.2_5'Flank|OSCAR_uc010erc.2_5'Flank|OSCAR_uc002qdc.2_5'Flank|OSCAR_uc002qdd.2_5'Flank|NDUFA3_uc002qdf.2_RNA	NM_004542	NP_004533	O95167	NDUA3_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	3					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			breast(1)	1	all_cancers(19;0.004)|all_epithelial(19;0.00195)|all_lung(19;0.0193)|Lung NSC(19;0.0358)|Breast(117;0.137)|Ovarian(34;0.19)				NADH(DB00157)	AAAGATGGCTGCGAGTAAGTG	0.692		NA									OREG0003682|OREG0003632	type=REGULATORY REGION|Gene=NDUFA3|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay|type=REGULATORY REGION|Gene=BC035023|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	9	11					0	0	0	0
ZNF471	57573	broad.mit.edu	37	19	57035959	57035959	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:57035959G>A	uc002qnh.2	+	5	656	c.523G>A	c.(523-525)GAG>AAG	p.E175K		NM_020813	NP_065864	Q9BX82	ZN471_HUMAN	zinc finger protein 471	175					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0307)		AAACATAGAAGAGAGTATTTA	0.284		NA											3	28					0	0	0	0
ZNF470	388566	broad.mit.edu	37	19	57088415	57088415	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:57088415G>C	uc002qnl.3	+	6	1294	c.618G>C	c.(616-618)AAG>AAC	p.K206N	ZNF470_uc010etn.2_Intron	NM_001001668	NP_001001668	Q6ECI4	ZN470_HUMAN	zinc finger protein 470	206					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0294)		ATACAGATAAGAAAAGCTTAA	0.289		NA											23	19					0	0	0	0
ZNF835	90485	broad.mit.edu	37	19	57175000	57175000	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr19:57175000G>T	uc010ygo.1	-	2	1633	c.1633C>A	c.(1633-1635)CAA>AAA	p.Q545K	ZNF835_uc010ygn.1_Missense_Mutation_p.Q523K	NM_001005850	NP_001005850			zinc finger protein 835											pancreas(3)|skin(1)	4						CACCCCTGTTGACAGGTTTCT	0.507		NA											18	63					9.17e-09	9.76e-09	1	0
RNASEH1	246243	broad.mit.edu	37	2	3599789	3599789	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:3599789C>T	uc002qxt.2	-	3	444	c.354G>A	c.(352-354)ATG>ATA	p.M118I	RNASEH1_uc002qxs.2_Missense_Mutation_p.M1I	NM_002936	NP_002927	O60930	RNH1_HUMAN	ribonuclease H1	118					RNA catabolic process	cytoplasm	magnesium ion binding|ribonuclease H activity|RNA binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)			OV - Ovarian serous cystadenocarcinoma(76;0.0713)|Epithelial(75;0.167)|all cancers(51;0.22)		CGCTCGGCTTCATGTGCTTTG	0.517		NA											15	38					0	0	0	0
GRHL1	29841	broad.mit.edu	37	2	10136059	10136059	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:10136059C>T	uc002raa.2	+	13	1723	c.1552C>T	c.(1552-1554)CCT>TCT	p.P518S	GRHL1_uc002rab.2_RNA|GRHL1_uc002rad.2_Missense_Mutation_p.P329S|GRHL1_uc010yjb.1_Missense_Mutation_p.P367S	NM_198182	NP_937825	Q9NZI5	GRHL1_HUMAN	grainyhead-like 1	518					cellular lipid metabolic process|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Golgi apparatus|nucleus	DNA binding			pancreas(1)|skin(1)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.172)|OV - Ovarian serous cystadenocarcinoma(76;0.246)		TGCTGTCCCTCCTTCTACCAA	0.458		NA											42	92					0	0	0	0
MFSD2B	388931	broad.mit.edu	37	2	24247130	24247130	+	Silent	SNP	G	G	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:24247130G>T	uc002reo.1	+	13	1493	c.1479G>T	c.(1477-1479)CTG>CTT	p.L493L		NM_001080473	NP_001073942	A6NFX1	MFS2B_HUMAN	major facilitator superfamily domain containing	493					transport	integral to membrane				ovary(2)	2						CCAGCCGGCTGAGCCTTCGGA	0.647		NA											7	1					0.000157383	0.000163837	1	0
SLC30A6	55676	broad.mit.edu	37	2	32445600	32445600	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:32445600C>G	uc002roe.1	+	14	1241	c.1204C>G	c.(1204-1206)CTA>GTA	p.L402V	SLC30A6_uc002rof.1_Missense_Mutation_p.L442V|SLC30A6_uc010ymw.1_Missense_Mutation_p.L373V|SLC30A6_uc010ezr.1_Missense_Mutation_p.L379V|SLC30A6_uc002rog.1_Missense_Mutation_p.L205V|SLC30A6_uc010ezs.1_Missense_Mutation_p.L328V|SLC30A6_uc002roh.1_Missense_Mutation_p.L205V	NM_017964	NP_060434	Q6NXT4	ZNT6_HUMAN	solute carrier family 30 (zinc transporter),	402	Cytoplasmic (Potential).					Golgi membrane|integral to membrane	zinc ion transmembrane transporter activity				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					AGTTATTCTTCTAAACACACA	0.418		NA											82	24					0	0	0	0
BIRC6	57448	broad.mit.edu	37	2	32688441	32688441	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:32688441C>T	uc010ezu.2	+	24	5067	c.4933C>T	c.(4933-4935)CAG>TAG	p.Q1645*		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	1645					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					TTTGAAGCTTCAGCAACAGGT	0.423		NA											5	18					0	0	0	0
PREPL	9581	broad.mit.edu	37	2	44565513	44565513	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:44565513C>T	uc002ruf.2	-	7	1167	c.1132G>A	c.(1132-1134)GAT>AAT	p.D378N	PREPL_uc002rug.2_Missense_Mutation_p.D378N|PREPL_uc002ruh.2_Intron|PREPL_uc010fax.2_Missense_Mutation_p.D378N|PREPL_uc002rui.3_Missense_Mutation_p.D289N|PREPL_uc002ruj.1_Missense_Mutation_p.D289N|PREPL_uc002ruk.1_Missense_Mutation_p.D378N	NM_006036	NP_006027	Q4J6C6	PPCEL_HUMAN	prolyl endopeptidase-like isoform C	378					proteolysis	cytosol	serine-type endopeptidase activity			ovary(1)	1		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				ACTGAATCATCAGCCAGACCA	0.328		NA											19	9					0	0	0	0
HK2	3099	broad.mit.edu	37	2	75115157	75115157	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:75115157G>C	uc002snd.2	+	16	4273	c.2347G>C	c.(2347-2349)GAA>CAA	p.E783Q		NM_000189	NP_000180	P52789	HXK2_HUMAN	hexokinase 2	783	Catalytic.				apoptotic mitochondrial changes|glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane	ATP binding|glucokinase activity			ovary(1)|lung(1)	2						GGGCATCTTTGAAACCAAGTT	0.512		NA											17	58					0	0	0	0
NCK2	8440	broad.mit.edu	37	2	106498397	106498397	+	Silent	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:106498397C>T	uc002tdg.2	+	4	1282	c.840C>T	c.(838-840)TTC>TTT	p.F280F	NCK2_uc002tdh.2_Intron|NCK2_uc002tdi.2_Silent_p.F280F	NM_003581	NP_003572	O43639	NCK2_HUMAN	NCK adaptor protein 2 isoform A	280					axon guidance|epidermal growth factor receptor signaling pathway|negative regulation of cell proliferation|positive regulation of actin filament polymerization|positive regulation of T cell proliferation|regulation of epidermal growth factor receptor activity|regulation of translation|signal complex assembly|T cell activation	cytosol|endoplasmic reticulum	cytoskeletal adaptor activity|receptor signaling complex scaffold activity			ovary(1)|lung(1)	2						GCGGGCGCTTCGCGGGCAGAG	0.672		NA											10	38					0	0	0	0
MYO7B	4648	broad.mit.edu	37	2	128354096	128354096	+	Silent	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:128354096C>T	uc002top.2	+	19	2357	c.2304C>T	c.(2302-2304)CTC>CTT	p.L768L		NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	768	IQ 2.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		GAGCGGCGCTCAGCATCCAGA	0.627		NA											3	12					0	0	0	0
YSK4	80122	broad.mit.edu	37	2	135738606	135738606	+	Silent	SNP	G	G	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:135738606G>T	uc002tue.1	-	9	3736	c.3705C>A	c.(3703-3705)GCC>GCA	p.A1235A	YSK4_uc002tuf.1_Silent_p.A417A|YSK4_uc010fnc.1_Silent_p.A369A|YSK4_uc010fnd.1_Silent_p.A1122A|YSK4_uc010zbg.1_Silent_p.A367A|YSK4_uc002tuh.3_Silent_p.A963A|YSK4_uc002tui.3_3'UTR	NM_025052	NP_079328	Q56UN5	YSK4_HUMAN	Yeast Sps1/Ste20-related kinase 4 isoform 1	1235	Protein kinase.			A -> V (in Ref. 2; BAB15538).			ATP binding|protein serine/threonine kinase activity			stomach(2)|urinary_tract(1)|ovary(1)|breast(1)	5				BRCA - Breast invasive adenocarcinoma(221;0.112)		TGACTTCTGGGGCCATCCAAT	0.502		NA											13	37					4.38e-07	4.64e-07	1	0
LRP1B	53353	broad.mit.edu	37	2	141771238	141771238	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:141771238T>C	uc002tvj.1	-	14	3239	c.2267A>G	c.(2266-2268)TAT>TGT	p.Y756C	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	756	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ACCATTCATATAATCAGTCCA	0.388		NA								TSP Lung(27;0.18)			45	52					0	0	0	0
DPP4	1803	broad.mit.edu	37	2	162865118	162865118	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:162865118G>C	uc002ubz.2	-	22	2502	c.1941C>G	c.(1939-1941)TTC>TTG	p.F647L	DPP4_uc010fpb.2_Missense_Mutation_p.F323L	NM_001935	NP_001926	P27487	DPP4_HUMAN	dipeptidylpeptidase IV	647	Extracellular (Potential).				cell adhesion|endothelial cell migration|negative regulation of extracellular matrix disassembly|positive regulation of cell proliferation|proteolysis|regulation of cell-cell adhesion mediated by integrin|response to hypoxia|T cell activation|T cell costimulation	apical plasma membrane|cell surface|endocytic vesicle|extracellular region|integral to membrane|invadopodium membrane|lamellipodium membrane|membrane raft	aminopeptidase activity|dipeptidyl-peptidase activity|protease binding|protein homodimerization activity|receptor activity|receptor binding|serine-type endopeptidase activity			ovary(3)	3					Sitagliptin(DB01261)	TTCCACACTTGAACACGCCAC	0.468		NA											16	48					0	0	0	0
IFIH1	64135	broad.mit.edu	37	2	163128753	163128753	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:163128753C>G	uc002uce.2	-	13	2821	c.2599G>C	c.(2599-2601)GAG>CAG	p.E867Q		NM_022168	NP_071451	Q9BYX4	IFIH1_HUMAN	interferon induced with helicase C domain 1	867	Helicase C-terminal.				detection of virus|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|regulation of apoptosis	cytosol|nucleus	ATP binding|DNA binding|double-stranded RNA binding|helicase activity|protein binding|ribonucleoprotein binding|zinc ion binding			ovary(1)	1						GCATACTCCTCTGGTTTCATA	0.378		NA											6	19					0	0	0	0
IFIH1	64135	broad.mit.edu	37	2	163144765	163144765	+	Silent	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:163144765G>A	uc002uce.2	-	5	1197	c.975C>T	c.(973-975)ATC>ATT	p.I325I		NM_022168	NP_071451	Q9BYX4	IFIH1_HUMAN	interferon induced with helicase C domain 1	325	Helicase ATP-binding.				detection of virus|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|regulation of apoptosis	cytosol|nucleus	ATP binding|DNA binding|double-stranded RNA binding|helicase activity|protein binding|ribonucleoprotein binding|zinc ion binding			ovary(1)	1						GGCAGATGATGATATTCTTCC	0.493		NA											27	66					0	0	0	0
SCN3A	6328	broad.mit.edu	37	2	165984368	165984368	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:165984368C>G	uc002ucx.2	-	18	3658	c.3166G>C	c.(3166-3168)GAA>CAA	p.E1056Q	SCN3A_uc002ucy.2_Missense_Mutation_p.E1007Q|SCN3A_uc002ucz.2_Missense_Mutation_p.E1007Q|SCN3A_uc002uda.1_Missense_Mutation_p.E876Q|SCN3A_uc002udb.1_Missense_Mutation_p.E876Q	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	1056						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	TTGCTTATTTCAATTCCAGTA	0.373		NA											16	58					0	0	0	0
SCN1A	6323	broad.mit.edu	37	2	166901607	166901607	+	Silent	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:166901607G>A	uc010zcz.1	-	10	1626	c.1608C>T	c.(1606-1608)TTC>TTT	p.F536F	SCN1A_uc002udo.3_Silent_p.F405F|SCN1A_uc010fpk.2_Silent_p.F405F	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	536						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	CTTCAATGGAGAAGCGAAAAC	0.428		NA											13	104					0	0	0	0
XIRP2	129446	broad.mit.edu	37	2	168107923	168107923	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:168107923G>C	uc002udx.2	+	8	10039	c.10021G>C	c.(10021-10023)GAG>CAG	p.E3341Q	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.E3166Q|XIRP2_uc010fpq.2_Missense_Mutation_p.E3119Q|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	3166				E -> G (in Ref. 8; CAD91141).	actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						CAGGGAATTTGAGCATGGCCC	0.393		NA											19	67					0	0	0	0
TLK1	9874	broad.mit.edu	37	2	171854298	171854298	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:171854298T>C	uc002ugn.2	-	19	2412	c.1940A>G	c.(1939-1941)GAG>GGG	p.E647G	TLK1_uc002ugo.2_Missense_Mutation_p.E668G|TLK1_uc002ugp.2_Missense_Mutation_p.E599G|TLK1_uc002ugq.2_RNA|TLK1_uc010zdn.1_Missense_Mutation_p.E551G	NM_012290	NP_036422	Q9UKI8	TLK1_HUMAN	tousled-like kinase 1 isoform 1	647	Protein kinase.				cell cycle|chromatin modification|intracellular protein transport|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)	1						CTTTGGTGGCTCTTTTCCAAC	0.373		NA											94	94					0	0	0	0
SCRN3	79634	broad.mit.edu	37	2	175264800	175264800	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:175264800G>A	uc002uiq.2	+	3	398	c.310G>A	c.(310-312)GAA>AAA	p.E104K	SCRN3_uc010zen.1_Missense_Mutation_p.E97K|SCRN3_uc010zeo.1_5'UTR|SCRN3_uc002uir.1_RNA	NM_024583	NP_078859	Q0VDG4	SCRN3_HUMAN	secernin 3	104					proteolysis		dipeptidase activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.229)			AGTTTGTGATGAAGAAGCACT	0.408		NA											38	126					0	0	0	0
CHN1	1123	broad.mit.edu	37	2	175666502	175666502	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:175666502C>T	uc002uji.2	-	12	1671	c.1141G>A	c.(1141-1143)GAA>AAA	p.E381K	CHN1_uc010zeq.1_Missense_Mutation_p.E355K|CHN1_uc002ujj.2_Missense_Mutation_p.E156K|CHN1_uc002ujg.2_Missense_Mutation_p.E256K	NM_001822	NP_001813	P15882	CHIN_HUMAN	chimerin (chimaerin) 1 isoform a	381	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.226)			TTCAGTGCTTCATGAAGGGTT	0.408		NA	T	TAF15	extraskeletal myxoid chondrosarcoma								30	107					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179599449	179599449	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:179599449C>T	uc010zfg.1	-	48	11694	c.11470G>A	c.(11470-11472)GAA>AAA	p.E3824K	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.E485K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	4751							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATAACTATTTCAGTACTGCAG	0.363		NA											19	80					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179640236	179640236	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:179640236C>T	uc010zfg.1	-	28	6579	c.6355G>A	c.(6355-6357)GAA>AAA	p.E2119K	TTN_uc010zfh.1_Missense_Mutation_p.E2073K|TTN_uc010zfi.1_Missense_Mutation_p.E2073K|TTN_uc010zfj.1_Missense_Mutation_p.E2073K|TTN_uc002unb.2_Missense_Mutation_p.E2119K|uc002unc.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	2119							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCAGACCGTTCAATTTTGACA	0.493		NA											9	22					0	0	0	0
CERKL	375298	broad.mit.edu	37	2	182468711	182468711	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:182468711G>T	uc002unx.2	-	2	435	c.334C>A	c.(334-336)CAG>AAG	p.Q112K	CERKL_uc002uny.2_Missense_Mutation_p.Q112K|CERKL_uc010zfm.1_Missense_Mutation_p.Q112K|CERKL_uc002unz.2_5'UTR|CERKL_uc002uoa.2_Missense_Mutation_p.Q112K|CERKL_uc002uob.2_5'UTR|CERKL_uc002uoc.2_Missense_Mutation_p.Q112K|CERKL_uc010frk.2_RNA|CERKL_uc002uod.1_5'UTR|CERKL_uc002uoe.2_Missense_Mutation_p.Q112K	NM_001030311	NP_001025482	Q49MI3	CERKL_HUMAN	ceramide kinase-like isoform b	112					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis	endoplasmic reticulum|endoplasmic reticulum|Golgi apparatus|Golgi apparatus|nucleolus|nucleolus	diacylglycerol kinase activity			ovary(2)|kidney(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.088)			CCACTTCTCTGCTGTTTAACA	0.318		NA											17	11					1.57e-10	1.68e-10	1	0
SSFA2	6744	broad.mit.edu	37	2	182767020	182767020	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:182767020G>C	uc002uoi.2	+	8	1562	c.1240G>C	c.(1240-1242)GAA>CAA	p.E414Q	SSFA2_uc002uoh.2_Missense_Mutation_p.E414Q|SSFA2_uc002uoj.2_Missense_Mutation_p.E414Q|SSFA2_uc002uok.2_RNA|SSFA2_uc010zfo.1_Missense_Mutation_p.E261Q|SSFA2_uc002uol.2_Missense_Mutation_p.E261Q	NM_001130445	NP_001123917	P28290	SSFA2_HUMAN	sperm specific antigen 2 isoform 1	414						cytoplasm|plasma membrane	actin binding			breast(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0856)			TGGTATTGTAGAATCCAAATT	0.368		NA											13	50					0	0	0	0
DNAH7	56171	broad.mit.edu	37	2	196673414	196673414	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:196673414C>T	uc002utj.3	-	53	10176	c.10075G>A	c.(10075-10077)GAT>AAT	p.D3359N		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3359					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						ACCAAACTATCATATACTTTC	0.323		NA											21	94					0	0	0	0
DNAH7	56171	broad.mit.edu	37	2	196729233	196729233	+	Silent	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:196729233C>G	uc002utj.3	-	41	7247	c.7146G>C	c.(7144-7146)GTG>GTC	p.V2382V		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2382	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						TCCTTAAGATCACTTTTAAAT	0.398		NA											16	71					0	0	0	0
SF3B1	23451	broad.mit.edu	37	2	198265441	198265441	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:198265441C>T	uc002uue.2	-	18	2764	c.2716G>A	c.(2716-2718)GAG>AAG	p.E906K		NM_012433	NP_036565	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1 isoform 1	906					nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding			pancreas(3)|ovary(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.246)			TTCATTACCTCTGTAGTCTGT	0.308		NA											16	77					0	0	0	0
CTLA4	1493	broad.mit.edu	37	2	204732684	204732684	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:204732684C>T	uc002vak.1	+	1	176	c.19C>T	c.(19-21)CAG>TAG	p.Q7*	CTLA4_uc002val.1_Nonsense_Mutation_p.Q7*|CTLA4_uc010fty.1_Nonsense_Mutation_p.Q7*|CTLA4_uc010ftz.1_RNA	NM_005214	NP_005205	P16410	CTLA4_HUMAN	cytotoxic T-lymphocyte-associated protein 4	7					B cell receptor signaling pathway|immune response|negative regulation of B cell proliferation|negative regulation of regulatory T cell differentiation|positive regulation of apoptosis|response to DNA damage stimulus|T cell costimulation	clathrin-coated endocytic vesicle|external side of plasma membrane|Golgi apparatus|integral to plasma membrane|perinuclear region of cytoplasm					0					Abatacept(DB01281)	CCTTGGATTTCAGCGGCACAA	0.498		NA											14	18					0	0	0	0
COL4A3	1285	broad.mit.edu	37	2	228159768	228159768	+	Silent	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:228159768G>A	uc002vom.1	+	40	3669	c.3507G>A	c.(3505-3507)AAG>AAA	p.K1169K	COL4A3_uc002von.1_Silent_p.K1169K|COL4A3_uc002voo.1_Silent_p.K1169K|COL4A3_uc002vop.1_Silent_p.K1169K|uc002voq.1_Intron|uc002vor.1_Intron	NM_000091	NP_000082	Q01955	CO4A3_HUMAN	alpha 3 type IV collagen isoform 1 precursor	1169	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			skin(2)|ovary(1)	3		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		CCGGAGAAAAGGGAGAAACGG	0.408		NA											54	25					0	0	0	0
SP100	6672	broad.mit.edu	37	2	231368918	231368918	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:231368918G>C	uc002vqt.2	+	21	1924	c.1783G>C	c.(1783-1785)GAT>CAT	p.D595H	SP100_uc002vqs.2_Missense_Mutation_p.D595H|SP100_uc002vqu.1_Missense_Mutation_p.D595H|SP100_uc010fxp.1_5'UTR	NM_003113	NP_003104	P23497	SP100_HUMAN	nuclear antigen Sp100 isoform 2	595	SAND.				DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|interspecies interaction between organisms|negative regulation of cellular component movement|negative regulation of DNA binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of transcription, DNA-dependent|negative regulation of viral transcription|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|response to cytokine stimulus|response to retinoic acid|response to type I interferon	cytoplasm|nuclear periphery|nucleolus|PML body	chromo shadow domain binding|DNA binding|identical protein binding|kinase binding|protein homodimerization activity|transcription coactivator activity|transcription corepressor activity|transcription factor binding			ovary(4)|central_nervous_system(1)	5		Renal(207;0.0112)|all_lung(227;0.0335)|all_hematologic(139;0.0749)|Lung NSC(271;0.142)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		AATTCCCAAAGATGAAAATAT	0.403		NA											20	50					0	0	0	0
ARMC9	80210	broad.mit.edu	37	2	232143099	232143099	+	Silent	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:232143099G>A	uc002vrq.3	+	16	1591	c.1479G>A	c.(1477-1479)AAG>AAA	p.K493K	ARMC9_uc002vrp.3_Silent_p.K493K|ARMC9_uc002vrr.1_RNA	NM_025139	NP_079415	Q7Z3E5	ARMC9_HUMAN	armadillo repeat containing 9	493							binding			ovary(1)	1		Renal(207;0.0112)|all_lung(227;0.0744)|all_hematologic(139;0.0749)|Acute lymphoblastic leukemia(138;0.167)|Medulloblastoma(418;0.184)|Lung NSC(271;0.205)		Epithelial(121;1.43e-10)|LUSC - Lung squamous cell carcinoma(224;0.017)|Lung(119;0.0189)		CCATAGGGAAGAACATGTGTG	0.363		NA											27	82					0	0	0	0
HDAC4	9759	broad.mit.edu	37	2	239990186	239990186	+	Silent	SNP	T	T	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr2:239990186T>C	uc002vyk.3	-	23	3645	c.2853A>G	c.(2851-2853)AGA>AGG	p.R951R	HDAC4_uc010fyy.2_Silent_p.R908R	NM_006037	NP_006028	P56524	HDAC4_HUMAN	histone deacetylase 4	951	Histone deacetylase.				B cell differentiation|cardiac muscle hypertrophy in response to stress|chromatin remodeling|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of glycolysis|negative regulation of myotube differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development|peptidyl-lysine deacetylation|positive regulation of cell proliferation|positive regulation of protein sumoylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|response to denervation involved in regulation of muscle adaptation|response to interleukin-1|transcription, DNA-dependent	histone deacetylase complex|transcriptional repressor complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|potassium ion binding|repressing transcription factor binding|zinc ion binding			breast(3)|skin(2)|ovary(1)	6		all_epithelial(40;1.45e-17)|Breast(86;1.53e-05)|Renal(207;0.000355)|all_lung(227;0.0121)|Ovarian(221;0.0183)|Lung NSC(271;0.0413)|Melanoma(123;0.0749)|all_hematologic(139;0.159)		Epithelial(121;6.38e-25)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-12)|Kidney(56;6.04e-08)|KIRC - Kidney renal clear cell carcinoma(57;1.18e-06)|BRCA - Breast invasive adenocarcinoma(100;3.99e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.04)		ACCACTTACATCTGGCGGAGA	0.572		NA											4	22					0	0	0	0
CDC25B	994	broad.mit.edu	37	20	3782998	3782998	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr20:3782998G>A	uc002wjn.2	+	11	1947	c.1169G>A	c.(1168-1170)CGA>CAA	p.R390Q	CDC25B_uc010zqk.1_Missense_Mutation_p.R326Q|CDC25B_uc010zql.1_Missense_Mutation_p.R312Q|CDC25B_uc010zqm.1_Missense_Mutation_p.R299Q|CDC25B_uc002wjl.2_Missense_Mutation_p.R278Q|CDC25B_uc002wjm.2_Missense_Mutation_p.R278Q|CDC25B_uc002wjo.2_Missense_Mutation_p.R376Q|CDC25B_uc002wjp.2_Missense_Mutation_p.R349Q|CDC25B_uc002wjq.2_Missense_Mutation_p.R190Q|CDC25B_uc010gbc.2_5'Flank	NM_021873	NP_068659	P30305	MPIP2_HUMAN	cell division cycle 25B isoform 1	390					cell division|G2/M transition of mitotic cell cycle|mitosis|positive regulation of cell proliferation	cytosol|microtubule organizing center|nucleoplasm	protein binding|protein tyrosine phosphatase activity			lung(3)|ovary(2)	5						AGTGACCACCGAGAGCTGATT	0.567		NA											13	22					0	0	0	0
FLRT3	23767	broad.mit.edu	37	20	14306766	14306766	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr20:14306766C>G	uc002wov.1	-	3	1854	c.1387G>C	c.(1387-1389)GAG>CAG	p.E463Q	MACROD2_uc002wot.2_Intron|MACROD2_uc002wou.2_Intron|FLRT3_uc002wow.1_Missense_Mutation_p.E463Q	NM_198391	NP_938205	Q9NZU0	FLRT3_HUMAN	fibronectin leucine rich transmembrane protein 3	463	Extracellular (Potential).|Fibronectin type-III.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			kidney(1)	1		Colorectal(1;0.0464)	COAD - Colon adenocarcinoma(2;0.129)	Colorectal(1;0.0393)		ACCAAGTACTCACTGCGTTCC	0.468		NA											16	32					0	0	0	0
XKR7	343702	broad.mit.edu	37	20	30584930	30584930	+	Silent	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr20:30584930G>A	uc002wxe.2	+	3	1584	c.1410G>A	c.(1408-1410)ACG>ACA	p.T470T		NM_001011718	NP_001011718	Q5GH72	XKR7_HUMAN	XK, Kell blood group complex subunit-related	470						integral to membrane				ovary(1)|breast(1)|skin(1)	3			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			ACGCCATCACGAGTCCCCCCA	0.682		NA											14	25					0	0	0	0
MAPRE1	22919	broad.mit.edu	37	20	31413815	31413815	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr20:31413815C>G	uc002wyh.2	+	2	221	c.82C>G	c.(82-84)CTG>GTG	p.L28V		NM_012325	NP_036457	Q15691	MARE1_HUMAN	microtubule-associated protein, RP/EB family,	28	CH.				cell division|cell proliferation|G2/M transition of mitotic cell cycle|mitotic prometaphase|negative regulation of microtubule polymerization|protein localization to microtubule	centrosome|cortical microtubule cytoskeleton|cytosol	microtubule plus-end binding|protein C-terminus binding				0						CAATGAGTCTCTGCAGTTGAA	0.433		NA											43	73					0	0	0	0
BPIL1	80341	broad.mit.edu	37	20	31607532	31607532	+	Silent	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr20:31607532C>T	uc002wyj.2	+	11	1250	c.1056C>T	c.(1054-1056)TTC>TTT	p.F352F		NM_025227	NP_079503	Q8N4F0	BPIL1_HUMAN	bactericidal/permeability-increasing	352						extracellular region	lipid binding			skin(2)|large_intestine(1)|ovary(1)	4						ACTCGGCTTTCCAGTCCCTCT	0.537		NA											6	27					0	0	0	0
PTPRT	11122	broad.mit.edu	37	20	40980903	40980903	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr20:40980903G>A	uc002xkg.2	-	10	1767	c.1583C>T	c.(1582-1584)TCG>TTG	p.S528L	PTPRT_uc010ggj.2_Missense_Mutation_p.S528L	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	528	Extracellular (Potential).|Fibronectin type-III 3.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				TGGGTCCAGCGAGCCGACAGC	0.532		NA											10	48					0	0	0	0
PTPRT	11122	broad.mit.edu	37	20	40980908	40980908	+	Silent	SNP	G	G	T	rs9941770		TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr20:40980908G>T	uc002xkg.2	-	10	1762	c.1578C>A	c.(1576-1578)GTC>GTA	p.V526V	PTPRT_uc010ggj.2_Silent_p.V526V	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	526	Extracellular (Potential).|Fibronectin type-III 3.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				CCAGCGAGCCGACAGCCTTGT	0.522		NA											10	48					1.05e-09	1.12e-09	1	0
SYCP2	10388	broad.mit.edu	37	20	58441392	58441392	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr20:58441392C>G	uc002yaz.2	-	40	4415	c.4276G>C	c.(4276-4278)GAA>CAA	p.E1426Q		NM_014258	NP_055073	Q9BX26	SYCP2_HUMAN	synaptonemal complex protein 2	1426					cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding			ovary(3)|lung(2)	5	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)			GAATCTTTTTCAAAATTCTCC	0.229		NA											14	60					0	0	0	0
CDH26	60437	broad.mit.edu	37	20	58547156	58547156	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr20:58547156G>T	uc002ybe.2	+	4	671	c.371G>T	c.(370-372)CGA>CTA	p.R124L	CDH26_uc010zzy.1_RNA	NM_177980	NP_817089	Q8IXH8	CAD26_HUMAN	cadherin-like 26 isoform a	124	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|central_nervous_system(1)	4	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)			CCTGTCGATCGAGAAATGACA	0.383		NA											15	49					3.53e-06	3.72e-06	1	0
DIDO1	11083	broad.mit.edu	37	20	61511034	61511034	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr20:61511034C>G	uc002ydr.1	-	16	6538	c.6274G>C	c.(6274-6276)GAC>CAC	p.D2092H	DIDO1_uc002yds.1_Missense_Mutation_p.D2092H	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	2092					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					GGCCCCACGTCAAACCGCTCT	0.612		NA											42	270					0	0	0	0
ARFRP1	10139	broad.mit.edu	37	20	62338354	62338354	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr20:62338354C>G	uc002yga.2	-	1	657	c.90G>C	c.(88-90)AAG>AAC	p.K30N	ARFRP1_uc002ygc.2_Missense_Mutation_p.K30N|ARFRP1_uc002ygh.3_Missense_Mutation_p.K30N|ARFRP1_uc011abf.1_Missense_Mutation_p.K30N|ARFRP1_uc011abg.1_Missense_Mutation_p.K30N|ARFRP1_uc002yge.2_RNA|ARFRP1_uc002ygd.2_RNA|ARFRP1_uc002ygf.2_Missense_Mutation_p.K30N|ARFRP1_uc002ygg.2_RNA|ARFRP1_uc011abh.1_RNA|ZGPAT_uc002ygi.2_5'Flank|ZGPAT_uc002ygj.2_5'Flank|ZGPAT_uc002ygk.2_5'Flank|ZGPAT_uc010gkk.1_5'Flank|ZGPAT_uc010gkl.1_5'Flank|ZGPAT_uc002ygm.2_5'Flank|ZGPAT_uc002ygn.3_5'Flank	NM_003224	NP_003215	Q13795	ARFRP_HUMAN	ADP-ribosylation factor related protein 1	30	GTP (By similarity).				small GTPase mediated signal transduction	Golgi apparatus|membrane fraction	GTP binding|GTPase activity			breast(1)|skin(1)	2	all_cancers(38;9.53e-13)|all_epithelial(29;2.64e-14)|Lung NSC(23;7e-10)|all_lung(23;2.53e-09)		Epithelial(9;4.09e-08)|all cancers(9;1.7e-07)|OV - Ovarian serous cystadenocarcinoma(5;0.0102)			CACTCACCGTCTTCCCAGCAT	0.607		NA											7	22					0	0	0	0
ZBTB46	140685	broad.mit.edu	37	20	62421736	62421736	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr20:62421736G>C	uc002ygv.1	-	2	576	c.375C>G	c.(373-375)ATC>ATG	p.I125M	ZBTB46_uc002ygu.2_RNA	NM_025224	NP_079500	Q86UZ6	ZBT46_HUMAN	zinc finger and BTB domain containing 46	125					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			large_intestine(1)|ovary(1)	2	all_cancers(38;2.09e-12)|all_epithelial(29;3.8e-14)|Lung NSC(23;7.61e-10)|all_lung(23;2.64e-09)					GCGCCGCCTTGATGAAGTCGT	0.612		NA											5	22					0	0	0	0
TPTE	7179	broad.mit.edu	37	21	10951399	10951400	+	Missense_Mutation	DNP	CC	CC	TT			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr21:10951399_10951400CC>TT	uc002yip.1	-	10	680_681	c.312_313GG>AA	c.(310-315)CTGGAT>CTAAAT	p.D105N	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.D87N|TPTE_uc002yir.1_Missense_Mutation_p.D67N|TPTE_uc010gkv.1_5'UTR	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	105	Helical; (Potential).				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		AGAGTGACATCCAGTAAGACCA	0.322		NA											18	113					0	0	0	0
KRTAP22-1	337979	broad.mit.edu	37	21	31973557	31973557	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr21:31973557G>A	uc011add.1	+	1	118	c.118G>A	c.(118-120)GAA>AAA	p.E40K	KRTAP6-2_uc011adc.1_5'Flank	NM_181620	NP_853651	Q3MIV0	KR221_HUMAN	keratin associated protein 22-1	40						intermediate filament					0						ATGGTGTTATGAAAGATCTTG	0.483		NA											37	155					0	0	0	0
SIM2	6493	broad.mit.edu	37	21	38072060	38072060	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr21:38072060C>G	uc002yvr.2	+	1	70	c.14C>G	c.(13-15)TCC>TGC	p.S5C	SIM2_uc002yvp.2_Missense_Mutation_p.S5C|SIM2_uc002yvq.2_Missense_Mutation_p.S5C	NM_005069	NP_005060	Q14190	SIM2_HUMAN	single-minded homolog 2 long isoform	5	Basic motif.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			central_nervous_system(1)	1						AAGGAGAAGTCCAAGAATGCG	0.662		NA											3	15					0	0	0	0
AGPAT3	56894	broad.mit.edu	37	21	45387862	45387862	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr21:45387862G>A	uc002zdv.2	+	4	436	c.214G>A	c.(214-216)GAG>AAG	p.E72K	AGPAT3_uc002zdw.2_Missense_Mutation_p.E72K|AGPAT3_uc002zdx.2_Missense_Mutation_p.E159K|AGPAT3_uc002zdy.2_Missense_Mutation_p.E10K	NM_020132	NP_064517	Q9NRZ7	PLCC_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 3	72	Cytoplasmic (Potential).				phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	1-acylglycerol-3-phosphate O-acyltransferase activity				0				STAD - Stomach adenocarcinoma(101;0.18)|Colorectal(79;0.24)		GTCCTGCACGGAGTGTACACT	0.612		NA											11	22					0	0	0	0
CABIN1	23523	broad.mit.edu	37	22	24563212	24563212	+	Silent	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr22:24563212G>A	uc002zzi.1	+	32	5740	c.5613G>A	c.(5611-5613)CAG>CAA	p.Q1871Q	CABIN1_uc002zzj.1_Silent_p.Q1792Q|CABIN1_uc002zzl.1_Silent_p.Q1871Q|CABIN1_uc002zzm.1_Silent_p.Q296Q	NM_012295	NP_036427	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	1871					cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						AGCAGGGCCAGAAGGGTGTGG	0.617		NA											3	43					0	0	0	0
BPIL2	254240	broad.mit.edu	37	22	32831730	32831730	+	Silent	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr22:32831730G>A	uc003amn.2	-	8	885	c.885C>T	c.(883-885)TTC>TTT	p.F295F	BPIL2_uc010gwo.2_Silent_p.F109F|BPIL2_uc011amb.1_Silent_p.F19F	NM_174932	NP_777592	Q8NFQ6	BPIL2_HUMAN	bactericidal/permeability-increasing	295						extracellular region	lipopolysaccharide binding|phospholipid binding			ovary(1)|skin(1)	2						CCCCAGCTGTGAAATGAGCAA	0.458		NA											17	19					0	0	0	0
NOL12	79159	broad.mit.edu	37	22	38084953	38084953	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr22:38084953A>G	uc003atp.2	+	4	391	c.335A>G	c.(334-336)GAC>GGC	p.D112G	NOL12_uc011anm.1_Missense_Mutation_p.D112G|NOL12_uc003ato.1_RNA|TRIOBP_uc003atq.1_5'UTR	NM_024313	NP_077289	Q9UGY1	NOL12_HUMAN	nucleolar protein 12	112						nucleolus	rRNA binding				0	Melanoma(58;0.0574)					ACCATCAGTGACCTGGACCTC	0.647		NA											32	109					0	0	0	0
MKL1	57591	broad.mit.edu	37	22	40816946	40816946	+	Silent	SNP	G	G	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr22:40816946G>T	uc003ayv.1	-	7	993	c.786C>A	c.(784-786)ATC>ATA	p.I262I	MKL1_uc003ayw.1_Silent_p.I262I|MKL1_uc010gye.1_Silent_p.I262I|MKL1_uc010gyf.1_Silent_p.I212I	NM_020831	NP_065882	Q969V6	MKL1_HUMAN	megakaryoblastic leukemia 1 protein	262					positive regulation of transcription from RNA polymerase II promoter|smooth muscle cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	actin monomer binding|leucine zipper domain binding|nucleic acid binding|transcription coactivator activity			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						GCTGCTGCAGGATCTTGGCGT	0.602		NA	T	RBM15	acute megakaryocytic leukemia								34	15					1.27e-14	1.37e-14	1	0
MKL1	57591	broad.mit.edu	37	22	40816975	40816975	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr22:40816975G>A	uc003ayv.1	-	7	964	c.757C>T	c.(757-759)CCC>TCC	p.P253S	MKL1_uc003ayw.1_Missense_Mutation_p.P253S|MKL1_uc010gye.1_Missense_Mutation_p.P253S|MKL1_uc010gyf.1_Missense_Mutation_p.P203S	NM_020831	NP_065882	Q969V6	MKL1_HUMAN	megakaryoblastic leukemia 1 protein	253	Mediates interaction with SCAI and ACTB (By similarity).				positive regulation of transcription from RNA polymerase II promoter|smooth muscle cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	actin monomer binding|leucine zipper domain binding|nucleic acid binding|transcription coactivator activity			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						TCCATGGGGGGTGCCCCCCTG	0.592		NA	T	RBM15	acute megakaryocytic leukemia								32	25					0	0	0	0
EP300	2033	broad.mit.edu	37	22	41573260	41573260	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr22:41573260T>C	uc003azl.3	+	31	5940	c.5545T>C	c.(5545-5547)TCC>CCC	p.S1849P		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1849					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						GGGCCTCCCTTCCCCCACTCC	0.637		NA	T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				3	53					0	0	0	0
SBF1	6305	broad.mit.edu	37	22	50904631	50904631	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr22:50904631G>A	uc003blh.2	-	8	1040	c.845C>T	c.(844-846)ACG>ATG	p.T282M	SBF1_uc011arx.1_Translation_Start_Site|SBF1_uc003bli.2_Missense_Mutation_p.T283M	NM_002972	NP_002963	O95248	MTMR5_HUMAN	SET binding factor 1	282	DENN.				protein dephosphorylation	integral to membrane|nucleus	protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)		GATGAAGGGCGTGGGTGTGCT	0.652		NA											20	42					0	0	0	0
CNTN4	152330	broad.mit.edu	37	3	3067795	3067795	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr3:3067795G>A	uc003bpc.2	+	14	1717	c.1496G>A	c.(1495-1497)AGG>AAG	p.R499K	CNTN4_uc003bpb.1_Missense_Mutation_p.R171K|CNTN4_uc003bpd.1_Missense_Mutation_p.R499K|CNTN4_uc003bpe.2_Missense_Mutation_p.R171K|CNTN4_uc003bpf.2_Missense_Mutation_p.R171K	NM_175607	NP_783200	Q8IWV2	CNTN4_HUMAN	contactin 4 isoform a precursor	499	Ig-like C2-type 6.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			large_intestine(2)|ovary(2)|lung(1)|central_nervous_system(1)|pancreas(1)	7		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		GATCCAACAAGGGTAATGGTA	0.418		NA											5	11					0	0	0	0
CRELD1	78987	broad.mit.edu	37	3	9979744	9979744	+	Silent	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr3:9979744C>T	uc003bug.2	+	5	532	c.414C>T	c.(412-414)TCC>TCT	p.S138S	CIDEC_uc003bto.2_Intron|CRELD1_uc003buf.2_Silent_p.S138S|CRELD1_uc003buh.2_Silent_p.S138S|CRELD1_uc003bui.2_Silent_p.S138S|CRELD1_uc003buj.2_RNA	NM_001077415	NP_001070883	Q96HD1	CREL1_HUMAN	cysteine-rich with EGF-like domains 1 isoform 3	138	Extracellular (Potential).				cardiac septum development|endocardial cushion development	integral to membrane	calcium ion binding			ovary(1)	1						GCTCAGATTCCCTGAAGCTCT	0.592		NA											19	5					0	0	0	0
BTD	686	broad.mit.edu	37	3	15677117	15677117	+	Silent	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr3:15677117C>T	uc003cah.2	+	2	334	c.231C>T	c.(229-231)ATC>ATT	p.I77I	BTD_uc011avv.1_Silent_p.I79I|BTD_uc011avw.1_Silent_p.I79I|BTD_uc011avx.1_Silent_p.I57I	NM_000060	NP_000051	P43251	BTD_HUMAN	biotinidase precursor	77	CN hydrolase.				central nervous system development|epidermis development|nitrogen compound metabolic process	extracellular space	biotin carboxylase activity|biotinidase activity				0						TGGCTCTCATCAGCCGCCAAG	0.542		NA											30	54					0	0	0	0
TOP2B	7155	broad.mit.edu	37	3	25666199	25666199	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr3:25666199C>T	uc011awn.1	-	19	2363	c.2320G>A	c.(2320-2322)GAG>AAG	p.E774K	TOP2B_uc003cdj.2_Missense_Mutation_p.E769K	NM_001068	NP_001059	Q02880	TOP2B_HUMAN	DNA topoisomerase II, beta isozyme	774					DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|resolution of meiotic recombination intermediates|sister chromatid segregation	cytosol|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex|WINAC complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity			breast(2)|ovary(1)|lung(1)|skin(1)	5						GCCGACATCTCAGCAACAGAG	0.363		NA											4	14					0	0	0	0
NBEAL2	23218	broad.mit.edu	37	3	47030591	47030591	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr3:47030591G>C	uc003cqp.2	+	4	465	c.286G>C	c.(286-288)GAG>CAG	p.E96Q	NBEAL2_uc003cqq.1_Missense_Mutation_p.E89Q	NM_015175	NP_055990	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	96							binding			ovary(1)	1		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		GGAGAACATAGAGGCAGGCCG	0.597		NA											8	10					0	0	0	0
ERC2	26059	broad.mit.edu	37	3	55984542	55984542	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr3:55984542G>A	uc003dhr.1	-	13	2570	c.2314C>T	c.(2314-2316)CAA>TAA	p.Q772*	ERC2_uc003dhq.1_RNA|ERC2_uc003dht.1_Nonsense_Mutation_p.Q251*	NM_015576	NP_056391	O15083	ERC2_HUMAN	cytomatrix protein p110	772	Potential.					cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		TCCAACTGTTGATTGTGCTTG	0.433		NA											14	30					0	0	0	0
CNTN3	5067	broad.mit.edu	37	3	74535745	74535745	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr3:74535745C>T	uc003dpm.1	-	3	300	c.220G>A	c.(220-222)GAA>AAA	p.E74K		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor	74	Ig-like C2-type 1.				cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		TAACGATGTTCCATACTCATA	0.363		NA											16	32					0	0	0	0
LSAMP	4045	broad.mit.edu	37	3	115560764	115560764	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr3:115560764C>T	uc003ebt.2	-	6	1347	c.847G>A	c.(847-849)GAG>AAG	p.E283K	LSAMP_uc011bis.1_Missense_Mutation_p.E283K	NM_002338	NP_002329	Q13449	LSAMP_HUMAN	limbic system-associated membrane protein	283	Ig-like C2-type 3.				cell adhesion|nervous system development	anchored to membrane|plasma membrane					0		all_cancers(1;0.00189)|all_epithelial(1;0.0366)|Myeloproliferative disorder(1037;0.17)|all_neural(597;0.208)|Lung NSC(201;0.215)		GBM - Glioblastoma multiforme(114;0.00117)|LUSC - Lung squamous cell carcinoma(41;0.0407)|Lung(219;0.152)		CCGTAGTGCTCCTCAGTGACG	0.507		NA											10	34					0	0	0	0
KTELC1	56983	broad.mit.edu	37	3	119198980	119198980	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr3:119198980G>T	uc003ecm.2	+	5	623	c.539G>T	c.(538-540)GGT>GTT	p.G180V	KTELC1_uc011biz.1_RNA|KTELC1_uc011bja.1_Missense_Mutation_p.G21V	NM_152305	NP_689518	Q8NBL1	PGLT1_HUMAN	KTEL (Lys-Tyr-Glu-Leu) containing 1 precursor	180						endoplasmic reticulum lumen	UDP-glucosyltransferase activity				0				GBM - Glioblastoma multiforme(114;0.233)		TATCCTACAGGTCTTGGACGG	0.418		NA											30	15					1.31e-18	1.42e-18	1	0
SEC61A1	29927	broad.mit.edu	37	3	127774526	127774526	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr3:127774526T>A	uc003ekb.2	+	4	336	c.152T>A	c.(151-153)TTT>TAT	p.F51Y	SEC61A1_uc003ekc.2_Translation_Start_Site|SEC61A1_uc003ekd.2_Intron	NM_013336	NP_037468	P61619	S61A1_HUMAN	Sec61 alpha 1 subunit	51	Helical; (Potential).				protein targeting to ER	integral to endoplasmic reticulum membrane	P-P-bond-hydrolysis-driven protein transmembrane transporter activity|protein binding|ribosome binding			ovary(1)	1						ATTCCCCTGTTTGGGATCATG	0.473		NA											31	109					0	0	0	0
COPB2	9276	broad.mit.edu	37	3	139093334	139093334	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr3:139093334C>T	uc003etf.3	-	7	878	c.748G>A	c.(748-750)GAT>AAT	p.D250N	COPB2_uc011bmv.1_Missense_Mutation_p.D221N|COPB2_uc010hui.2_Missense_Mutation_p.D221N|COPB2_uc011bmw.1_Missense_Mutation_p.D250N	NM_004766	NP_004757	P35606	COPB2_HUMAN	coatomer protein complex, subunit beta 2 (beta	250	WD 6.				COPI coating of Golgi vesicle|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity			ovary(2)	2						AACTTACCATCTTCTGAACCT	0.403		NA											30	70					0	0	0	0
PLSCR4	57088	broad.mit.edu	37	3	145918834	145918834	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr3:145918834C>G	uc010huy.2	-	5	714	c.385G>C	c.(385-387)GAG>CAG	p.E129Q	PLSCR4_uc010huz.2_Missense_Mutation_p.E129Q|PLSCR4_uc003evt.3_Missense_Mutation_p.E129Q|PLSCR4_uc010hva.2_Intron|PLSCR4_uc003evu.3_Intron	NM_001128305	NP_001121777	Q9NRQ2	PLS4_HUMAN	phospholipid scramblase 4 isoform a	129	Cytoplasmic (By similarity).				blood coagulation|phospholipid scrambling	integral to membrane	calcium ion binding|phospholipid scramblase activity|SH3 domain binding				0						TCCAGAGGCTCAAAATGCTGA	0.318		NA											8	39					0	0	0	0
MME	4311	broad.mit.edu	37	3	154834751	154834751	+	Silent	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr3:154834751G>A	uc010hvr.1	+	7	841	c.630G>A	c.(628-630)AAG>AAA	p.K210K	MME_uc003fab.1_Silent_p.K210K|MME_uc003fac.1_Silent_p.K210K|MME_uc003fad.1_Silent_p.K210K|MME_uc003fae.1_Silent_p.K210K	NM_007289	NP_009220	P08473	NEP_HUMAN	membrane metallo-endopeptidase	210	Extracellular (Potential).				cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(2)|central_nervous_system(1)	3		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	CTGATGATAAGAATTCTGTGA	0.299		NA											7	29					0	0	0	0
VEPH1	79674	broad.mit.edu	37	3	156978935	156978935	+	Silent	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr3:156978935G>C	uc003fbj.1	-	14	2807	c.2490C>G	c.(2488-2490)ACC>ACG	p.T830T	VEPH1_uc003fbk.1_Silent_p.T830T|VEPH1_uc010hvu.1_Silent_p.T785T	NM_024621	NP_078897	Q14D04	MELT_HUMAN	ventricular zone expressed PH domain homolog 1	830						plasma membrane				breast(3)|ovary(1)|lung(1)	5			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			ACAGATATGTGGTTACTTCTC	0.408		NA											14	74					0	0	0	0
PLD1	5337	broad.mit.edu	37	3	171323140	171323140	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr3:171323140G>C	uc003fhs.2	-	26	3065	c.2949C>G	c.(2947-2949)TTC>TTG	p.F983L	PLD1_uc003fht.2_Missense_Mutation_p.F945L	NM_002662	NP_002653	Q13393	PLD1_HUMAN	phospholipase D1 isoform a	983					cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			ovary(2)|lung(1)	3	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)	ACACCTCCTTGAAGAATTTGT	0.443		NA											33	95					0	0	0	0
MCF2L2	23101	broad.mit.edu	37	3	182923663	182923663	+	Splice_Site	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr3:182923663C>T	uc003fli.1	-	25	2974	c.2884_splice	c.e25+1	p.D962_splice		NM_015078	NP_055893	Q86YR7	MF2L2_HUMAN	Rho family guanine-nucleotide exchange factor						regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)|large_intestine(2)|breast(1)	5	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			GGGTAACCTACCTTTGATATT	0.378		NA											3	21					0	0	0	0
MAP3K13	9175	broad.mit.edu	37	3	185183579	185183579	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr3:185183579G>A	uc010hyf.2	+	10	1699	c.1433G>A	c.(1432-1434)CGG>CAG	p.R478Q	MAP3K13_uc011brt.1_Missense_Mutation_p.R271Q|MAP3K13_uc011bru.1_Missense_Mutation_p.R334Q|MAP3K13_uc003fpi.2_Missense_Mutation_p.R478Q|MAP3K13_uc010hyg.2_Missense_Mutation_p.R168Q	NM_004721	NP_004712	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase	478					activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			ovary(2)|skin(1)	3	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			AAGCTTGAGCGGGCGAATAAT	0.473		NA											19	87					0	0	0	0
ACAP2	23527	broad.mit.edu	37	3	195015475	195015475	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr3:195015475C>A	uc003fun.3	-	18	1979	c.1738G>T	c.(1738-1740)GTG>TTG	p.V580L		NM_012287	NP_036419	Q15057	ACAP2_HUMAN	centaurin, beta 2	580					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			large_intestine(1)|ovary(1)	2						TTGGCTGACACCGTGGAGGGT	0.363		NA											8	54					2.18e-05	2.28e-05	1	0
LRCH3	84859	broad.mit.edu	37	3	197553768	197553768	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr3:197553768G>C	uc011bul.1	+	5	665	c.660G>C	c.(658-660)TTG>TTC	p.L220F	LRCH3_uc003fyj.1_Missense_Mutation_p.L220F|LRCH3_uc011bum.1_Missense_Mutation_p.L220F|LRCH3_uc011bun.1_Missense_Mutation_p.L94F|LRCH3_uc003fyk.2_5'Flank	NM_032773	NP_116162	Q96II8	LRCH3_HUMAN	leucine-rich repeats and calponin homology (CH)	220	LRR 7.					extracellular region				ovary(1)	1	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;4.82e-24)|all cancers(36;3.61e-22)|OV - Ovarian serous cystadenocarcinoma(49;7.08e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.119)		AGTTGCCTTTGATACGGTTAG	0.383		NA											20	93					0	0	0	0
GSX2	170825	broad.mit.edu	37	4	54967925	54967925	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr4:54967925C>G	uc010igp.1	+	2	1015	c.751C>G	c.(751-753)CAG>GAG	p.Q251E	PDGFRA_uc003haa.2_Intron	NM_133267	NP_573574	Q9BZM3	GSX2_HUMAN	GS homeobox 2	251	Homeobox.					nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	all_cancers(7;0.00671)|Lung NSC(11;0.0154)|all_neural(26;0.0209)|Glioma(25;0.08)|all_epithelial(27;0.147)		LUSC - Lung squamous cell carcinoma(32;0.00216)			AATCTGGTTTCAGAACCGCCG	0.567		NA											5	86					0	0	0	0
LPHN3	23284	broad.mit.edu	37	4	62897307	62897307	+	Silent	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr4:62897307C>T	uc010ihh.2	+	20	3539	c.3366C>T	c.(3364-3366)TTC>TTT	p.F1122F	LPHN3_uc003hcq.3_Silent_p.F1122F|LPHN3_uc003hct.2_Silent_p.F506F	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	1100	Helical; Name=7; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						TATTTATTTTCCATTGTGTCC	0.333		NA											26	12					0	0	0	0
CDKL2	8999	broad.mit.edu	37	4	76551024	76551024	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr4:76551024C>T	uc003hiq.2	-	2	674	c.149G>A	c.(148-150)CGA>CAA	p.R50Q	CDKL2_uc011cbp.1_Missense_Mutation_p.R50Q|CDKL2_uc010iix.1_RNA	NM_003948	NP_003939	Q92772	CDKL2_HUMAN	cyclin-dependent kinase-like 2	50	Protein kinase.|[NKR]KIAxRE.				sex differentiation|signal transduction	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity			ovary(2)|stomach(2)|breast(2)|skin(1)	7			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			CTTGATTTCTCGCATTGCAAT	0.299		NA											13	35					0	0	0	0
SCD5	79966	broad.mit.edu	37	4	83719652	83719652	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr4:83719652G>C	uc003hna.2	-	1	359	c.39C>G	c.(37-39)TTC>TTG	p.F13L	SCD5_uc003hnb.3_Missense_Mutation_p.F13L|SCD5_uc003hnc.2_Missense_Mutation_p.F13L	NM_001037582	NP_001032671	Q86SK9	SCD5_HUMAN	stearoyl-CoA desaturase 5 isoform a	13					fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	iron ion binding|stearoyl-CoA 9-desaturase activity			ovary(1)	1		Colorectal(4;0.0323)|Hepatocellular(203;0.115)				TGGCGTCGCAGAAAGGGATCT	0.736		NA											6	6					0	0	0	0
MMRN1	22915	broad.mit.edu	37	4	90857798	90857798	+	Silent	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr4:90857798G>A	uc003hst.2	+	6	3038	c.2967G>A	c.(2965-2967)TCG>TCA	p.S989S	MMRN1_uc010iku.2_Intron|MMRN1_uc011cds.1_Silent_p.S731S	NM_007351	NP_031377	Q13201	MMRN1_HUMAN	multimerin 1	989					cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				ovary(4)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		TAGATCGATCGTTGCCTGGTA	0.353		NA											36	16					0	0	0	0
BMPR1B	658	broad.mit.edu	37	4	96046186	96046186	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr4:96046186G>C	uc003htm.3	+	8	773	c.499G>C	c.(499-501)GAA>CAA	p.E167Q	BMPR1B_uc010ilb.2_Missense_Mutation_p.E167Q|BMPR1B_uc003htn.3_Missense_Mutation_p.E167Q	NM_001203	NP_001194	O00238	BMR1B_HUMAN	bone morphogenetic protein receptor, type IB	167	Cytoplasmic (Potential).				BMP signaling pathway|cartilage condensation|eye development|limb morphogenesis|ovarian cumulus expansion|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	receptor complex	ATP binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta receptor activity			lung(4)|skin(2)|stomach(1)|breast(1)	8		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.51e-07)		AGAACAGGATGAAACTTACAT	0.408		NA											10	21					0	0	0	0
ADH4	127	broad.mit.edu	37	4	100062796	100062796	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr4:100062796A>G	uc003hun.2	-	3	234	c.158T>C	c.(157-159)GTT>GCT	p.V53A	uc003hum.1_Intron|ADH4_uc011ced.1_Missense_Mutation_p.V72A	NM_000670	NP_000661	P08319	ADH4_HUMAN	class II alcohol dehydrogenase, pi subunit	53					alcohol catabolic process|cellular aldehyde metabolic process|ethanol oxidation|quinone cofactor metabolic process|retinol metabolic process|xenobiotic metabolic process	cytosol|microtubule cytoskeleton	alcohol dehydrogenase activity, zinc-dependent|all-trans retinal binding|benzaldehyde dehydrogenase activity|NAD binding|NADPH:quinone reductase activity|retinol binding|retinol dehydrogenase activity|zinc ion binding			skin(2)	2				OV - Ovarian serous cystadenocarcinoma(123;4.48e-08)	NADH(DB00157)	AGAATCGATAACAGTGGCATC	0.443		NA											18	32					0	0	0	0
NFKB1	4790	broad.mit.edu	37	4	103534639	103534639	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr4:103534639G>A	uc011ceq.1	+	23	3114	c.2647G>A	c.(2647-2649)GAA>AAA	p.E883K	NFKB1_uc011cep.1_Missense_Mutation_p.E884K|NFKB1_uc011cer.1_Missense_Mutation_p.E703K	NM_003998	NP_003989	P19838	NFKB1_HUMAN	nuclear factor kappa-B, subunit 1 isoform 1	883	Death.|Interaction with CFLAR.				anti-apoptosis|apoptosis|cellular response to mechanical stimulus|inflammatory response|innate immune response|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of calcidiol 1-monooxygenase activity|nerve growth factor receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter	cytosol|I-kappaB/NF-kappaB complex|mitochondrion|nucleoplasm	protein binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(2)|breast(2)|skin(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.59e-08)	Dexamethasone(DB01234)|Pranlukast(DB01411)|Thalidomide(DB01041)	GGGCTACACCGAAGCAATTGA	0.567		NA											8	21					0	0	0	0
KIAA1109	84162	broad.mit.edu	37	4	123249442	123249442	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr4:123249442G>A	uc003ieh.2	+	64	11224	c.11179G>A	c.(11179-11181)GAA>AAA	p.E3727K	KIAA1109_uc003iem.2_Missense_Mutation_p.E118K	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	3727					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						TTCTACCAGTGAAGATTCCGA	0.423		NA											22	43					0	0	0	0
SPATA5	166378	broad.mit.edu	37	4	123977581	123977581	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr4:123977581A>G	uc003iez.3	+	12	2192	c.2119A>G	c.(2119-2121)AGA>GGA	p.R707G		NM_145207	NP_660208	Q8NB90	SPAT5_HUMAN	spermatogenesis associated 5	707					cell differentiation|multicellular organismal development|spermatogenesis	mitochondrion	ATP binding|nucleoside-triphosphatase activity				0						TGAATCTGAAAGAGCAGTTAG	0.383		NA											10	13					0	0	0	0
FAT4	79633	broad.mit.edu	37	4	126238739	126238739	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr4:126238739C>G	uc003ifj.3	+	1	1173	c.1173C>G	c.(1171-1173)AAC>AAG	p.N391K		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	391	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CCGCGGCCAACGGGAACATCT	0.607		NA									OREG0016317	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	21					0	0	0	0
LARP1B	55132	broad.mit.edu	37	4	129043203	129043203	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr4:129043203C>T	uc003iga.2	+	11	1515	c.1384C>T	c.(1384-1386)CCT>TCT	p.P462S	LARP1B_uc003igc.2_5'UTR|LARP1B_uc003ifz.1_Missense_Mutation_p.P462S|LARP1B_uc003igb.1_Missense_Mutation_p.P177S	NM_018078	NP_060548	Q659C4	LAR1B_HUMAN	La ribonucleoprotein domain family member 2	462							RNA binding				0						GAAAAAACATCCTGGAGGAGA	0.368		NA											41	38					0	0	0	0
POU4F2	5458	broad.mit.edu	37	4	147561835	147561835	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr4:147561835C>T	uc003ikv.2	+	2	1353	c.1105C>T	c.(1105-1107)CGG>TGG	p.R369W		NM_004575	NP_004566	Q12837	PO4F2_HUMAN	Brn3b POU domain transcription factor	369	Homeobox.				estrogen receptor signaling pathway|MAPKKK cascade|negative regulation of transcription from RNA polymerase II promoter	nuclear speck	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			breast(1)	1	all_hematologic(180;0.151)					CATTCAGCCTCGGCCCTCCTC	0.577		NA											18	52					0	0	0	0
MAB21L2	10586	broad.mit.edu	37	4	151504859	151504859	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr4:151504859G>C	uc003ilw.2	+	1	1783	c.678G>C	c.(676-678)GAG>GAC	p.E226D	LRBA_uc003ils.3_5'Flank|LRBA_uc003ilt.3_Intron|LRBA_uc003ilu.3_Intron|LRBA_uc010ipj.2_Intron	NM_006439	NP_006430	Q9Y586	MB212_HUMAN	mab-21-like protein 2	226					nervous system development	nucleus				ovary(1)	1	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.159)		GCTCGGCAGAGAGCGACGCCT	0.647		NA											12	41					0	0	0	0
NAF1	92345	broad.mit.edu	37	4	164069513	164069513	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr4:164069513G>C	uc003iqj.2	-	3	808	c.614C>G	c.(613-615)TCA>TGA	p.S205*	NAF1_uc010iqw.1_Nonsense_Mutation_p.S205*	NM_138386	NP_612395	Q96HR8	NAF1_HUMAN	nuclear assembly factor 1 homolog isoform a	205					rRNA processing|snRNA pseudouridine synthesis	cytoplasm|nucleus|small nucleolar ribonucleoprotein complex	protein binding|snoRNA binding			ovary(2)	2	all_hematologic(180;0.166)	Prostate(90;0.109)				AATAATACTTGAAACCATCCC	0.284		NA											9	99					0	0	0	0
TKTL2	84076	broad.mit.edu	37	4	164393894	164393894	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr4:164393894T>A	uc003iqp.3	-	1	1154	c.993A>T	c.(991-993)AAA>AAT	p.K331N		NM_032136	NP_115512	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	331						cytoplasm	metal ion binding|transketolase activity			ovary(2)|skin(2)|pancreas(1)	5	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				cacggcccagtttagccagag	0.194		NA											28	82					0	0	0	0
DDX60L	91351	broad.mit.edu	37	4	169317111	169317111	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr4:169317111G>C	uc003irq.3	-	27	3877	c.3656C>G	c.(3655-3657)TCA>TGA	p.S1219*	DDX60L_uc003irr.1_Nonsense_Mutation_p.S1220*|DDX60L_uc003irs.1_Nonsense_Mutation_p.S914*	NM_001012967	NP_001012985	Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	1219	Helicase C-terminal.						ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		CTGACGTACTGAGTCTTTATT	0.343		NA											4	23					0	0	0	0
DDX60L	91351	broad.mit.edu	37	4	169393962	169393962	+	Splice_Site	SNP	T	T	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr4:169393962T>C	uc003irq.3	-	2	112	c.-109_splice	c.e2-1		DDX60L_uc003irr.1_Splice_Site|DDX60L_uc003irt.1_Splice_Site	NM_001012967	NP_001012985	Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like								ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		ATGGCACCTCTGTAATAAAAG	0.343		NA											12	5					0	0	0	0
AADAT	51166	broad.mit.edu	37	4	170989840	170989840	+	Splice_Site	SNP	T	T	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr4:170989840T>G	uc003isr.2	-	8	1146	c.804_splice	c.e8-1	p.G268_splice	AADAT_uc003iss.2_Splice_Site_p.G268_splice|AADAT_uc003ist.2_Splice_Site_p.G272_splice	NM_016228	NP_057312	Q8N5Z0	AADAT_HUMAN	kynurenine aminotransferase II						2-oxoglutarate metabolic process|biosynthetic process|glutamate metabolic process|lysine catabolic process	mitochondrial matrix	2-aminoadipate transaminase activity|kynurenine-oxoglutarate transaminase activity|protein homodimerization activity				0		Prostate(90;0.00601)|Renal(120;0.0183)|all_neural(102;0.122)|Melanoma(52;0.17)		GBM - Glioblastoma multiforme(119;0.0355)|LUSC - Lung squamous cell carcinoma(193;0.118)	L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	ATTCTCAACCTACGTGGAAAG	0.363		NA											6	54					0	0	0	0
SEMA5A	9037	broad.mit.edu	37	5	9154808	9154808	+	Splice_Site	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr5:9154808C>G	uc003jek.2	-	12	1986	c.1274_splice	c.e12-1	p.D425_splice		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor						cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						GTTCCGTAATCTATGAAGGTC	0.498		NA											29	130					0	0	0	0
DNAH5	1767	broad.mit.edu	37	5	13923469	13923469	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr5:13923469C>T	uc003jfd.2	-	4	400	c.358G>A	c.(358-360)GAT>AAT	p.D120N	DNAH5_uc003jfe.1_RNA	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	120	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					AGAGCCACATCGTTTCCCTCG	0.458		NA							Kartagener_syndrome				24	303					0	0	0	0
MYO10	4651	broad.mit.edu	37	5	16676206	16676206	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr5:16676206G>A	uc003jft.3	-	34	5068	c.4600C>T	c.(4600-4602)CGA>TGA	p.R1534*	MYO10_uc011cnb.1_Nonsense_Mutation_p.R163*|MYO10_uc011cnc.1_Nonsense_Mutation_p.R413*|MYO10_uc011cnd.1_Nonsense_Mutation_p.R891*|MYO10_uc011cne.1_Nonsense_Mutation_p.R891*|MYO10_uc010itx.2_Nonsense_Mutation_p.R1156*	NM_012334	NP_036466	Q9HD67	MYO10_HUMAN	myosin X	1534					axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			ovary(2)|pancreas(1)	3						TGGGTGTATCGAAGGATCGGG	0.493		NA											19	141					0	0	0	0
MTMR12	54545	broad.mit.edu	37	5	32230321	32230321	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr5:32230321C>G	uc003jhq.2	-	16	1977	c.1807G>C	c.(1807-1809)GAT>CAT	p.D603H	MTMR12_uc010iuk.2_Missense_Mutation_p.D549H|MTMR12_uc010iul.2_Missense_Mutation_p.D493H	NM_001040446	NP_001035536	Q9C0I1	MTMRC_HUMAN	myotubularin related protein 12	603	Myotubularin phosphatase.					cytoplasm	phosphatase activity			ovary(1)	1						TGGAGCTCATCAGAAGAATTA	0.403		NA											26	155					0	0	0	0
TTC23L	153657	broad.mit.edu	37	5	34863022	34863022	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr5:34863022G>T	uc003jiu.2	+	5	502	c.399G>T	c.(397-399)AAG>AAT	p.K133N	TTC23L_uc003jiv.2_5'Flank|TTC23L_uc010iut.1_5'Flank	NM_144725	NP_653326	Q6PF05	TT23L_HUMAN	tetratricopeptide repeat domain 23-like	133							binding			central_nervous_system(1)	1						TTCAGGCCAAGAAACATGCTA	0.478		NA											13	69					9.31e-06	9.81e-06	1	0
WDR70	55100	broad.mit.edu	37	5	37725096	37725096	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr5:37725096A>G	uc003jkv.2	+	16	1716	c.1658A>G	c.(1657-1659)AAG>AGG	p.K553R		NM_018034	NP_060504	Q9NW82	WDR70_HUMAN	WD repeat domain 70	553										ovary(1)|central_nervous_system(1)	2	all_lung(31;0.000285)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CAGCTGGAGAAGGACAGACTG	0.502		NA											119	103					0	0	0	0
EGFLAM	133584	broad.mit.edu	37	5	38451422	38451422	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr5:38451422C>G	uc003jlc.1	+	20	2897	c.2573C>G	c.(2572-2574)TCA>TGA	p.S858*	EGFLAM_uc003jlb.1_Nonsense_Mutation_p.S850*|EGFLAM_uc003jle.1_Nonsense_Mutation_p.S616*|EGFLAM_uc003jlf.1_Nonsense_Mutation_p.S216*|EGFLAM_uc003jlg.1_5'UTR	NM_152403	NP_689616	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G	858	Laminin G-like 3.					cell junction|proteinaceous extracellular matrix|synapse				pancreas(3)|skin(3)|ovary(1)	7	all_lung(31;0.000385)					TCCAGGGTGTCAGGATCAAGA	0.478		NA											38	297					0	0	0	0
RICTOR	253260	broad.mit.edu	37	5	38991111	38991111	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr5:38991111C>G	uc003jlp.2	-	7	547	c.523G>C	c.(523-525)GAT>CAT	p.D175H	RICTOR_uc003jlo.2_Missense_Mutation_p.D175H|RICTOR_uc010ivf.2_5'UTR|RICTOR_uc003jlq.1_Missense_Mutation_p.D159H|RICTOR_uc011cpk.1_Missense_Mutation_p.D175H	NM_152756	NP_689969	Q6R327	RICTR_HUMAN	rapamycin-insensitive companion of mTOR	175					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			ovary(3)|lung(3)|skin(2)|kidney(1)|central_nervous_system(1)	10	all_lung(31;0.000396)					TGAAGTCCATCATTTCCAACT	0.353		NA											4	99					0	0	0	0
PAIP1	10605	broad.mit.edu	37	5	43527498	43527498	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr5:43527498C>G	uc003job.2	-	11	1667	c.1420G>C	c.(1420-1422)GAG>CAG	p.E474Q	PAIP1_uc003joa.2_Missense_Mutation_p.E395Q|PAIP1_uc010ivp.2_3'UTR|PAIP1_uc010ivo.2_RNA|PAIP1_uc003joc.2_Missense_Mutation_p.E362Q	NM_006451	NP_006442	Q9H074	PAIP1_HUMAN	poly(A) binding protein interacting protein 1	474	PABPC1-interacting motif-1 (PAM1).				mRNA stabilization|nuclear-transcribed mRNA poly(A) tail shortening|translational initiation	cytosol	protein binding|RNA binding|translation activator activity			ovary(1)	1	Lung NSC(6;2.07e-05)					CGCTTACGCTCTGATTCCAAA	0.338		NA											8	79					0	0	0	0
PAIP1	10605	broad.mit.edu	37	5	43527528	43527528	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr5:43527528C>G	uc003job.2	-	11	1637	c.1390G>C	c.(1390-1392)GAA>CAA	p.E464Q	PAIP1_uc003joa.2_Missense_Mutation_p.E385Q|PAIP1_uc010ivp.2_3'UTR|PAIP1_uc010ivo.2_RNA|PAIP1_uc003joc.2_Missense_Mutation_p.E352Q	NM_006451	NP_006442	Q9H074	PAIP1_HUMAN	poly(A) binding protein interacting protein 1	464	PABPC1-interacting motif-1 (PAM1).				mRNA stabilization|nuclear-transcribed mRNA poly(A) tail shortening|translational initiation	cytosol	protein binding|RNA binding|translation activator activity			ovary(1)	1	Lung NSC(6;2.07e-05)					TCATAAGCTTCTTCTATCTCT	0.328		NA											11	81					0	0	0	0
PRR16	51334	broad.mit.edu	37	5	120022237	120022237	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr5:120022237C>A	uc003ksq.2	+	2	911	c.748C>A	c.(748-750)CCC>ACC	p.P250T	PRR16_uc003ksp.2_Missense_Mutation_p.P227T|PRR16_uc003ksr.2_Missense_Mutation_p.P180T	NM_016644	NP_057728	Q569H4	PRR16_HUMAN	proline rich 16	250	Pro-rich.									pancreas(2)|ovary(1)	3		all_cancers(142;0.0464)|Prostate(80;0.00446)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.000126)|Epithelial(69;0.000331)|all cancers(49;0.00169)		CCAAGGCCCTCCCCTCCCTCC	0.522		NA											19	16					2.46e-09	2.63e-09	1	0
FBN2	2201	broad.mit.edu	37	5	127645021	127645021	+	Silent	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr5:127645021C>G	uc003kuu.2	-	41	5710	c.5271G>C	c.(5269-5271)GTG>GTC	p.V1757V		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	1757	TB 7.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TCCTTTTTGTCACATTGAAAG	0.428		NA											4	48					0	0	0	0
KDM3B	51780	broad.mit.edu	37	5	137735696	137735696	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr5:137735696G>A	uc003lcy.1	+	11	3394	c.3194G>A	c.(3193-3195)CGC>CAC	p.R1065H	KDM3B_uc010jew.1_Missense_Mutation_p.R721H|KDM3B_uc011cys.1_Missense_Mutation_p.R97H	NM_016604	NP_057688	Q7LBC6	KDM3B_HUMAN	jumonji domain containing 1B	1065					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(3)|upper_aerodigestive_tract(2)|lung(2)|kidney(2)|central_nervous_system(1)|skin(1)	11						AGCCGGCCACGCAGTGGTAAG	0.478		NA											4	61					0	0	0	0
PCDHB7	56129	broad.mit.edu	37	5	140554059	140554059	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr5:140554059G>A	uc003lit.2	+	1	1817	c.1643G>A	c.(1642-1644)CGC>CAC	p.R548H		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	548	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCGCTGGTGCGCGTGCTGGTG	0.726		NA											50	29					0	0	0	0
PCDHGA4	56111	broad.mit.edu	37	5	140737171	140737171	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr5:140737171G>C	uc003ljq.1	+	1	2404	c.2404G>C	c.(2404-2406)GGA>CGA	p.G802R	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGB2_uc003ljs.1_5'Flank|PCDHGA4_uc003ljp.1_Missense_Mutation_p.G802R|PCDHGB2_uc011dar.1_5'Flank	NM_018917	NP_061740	Q9Y5G9	PCDG4_HUMAN	protocadherin gamma subfamily A, 4 isoform 1	802	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGAAACAAAAGGAGACCCTAA	0.393		NA											11	26					0	0	0	0
CYFIP2	26999	broad.mit.edu	37	5	156751060	156751060	+	Silent	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr5:156751060C>T	uc003lwq.2	+	18	1941	c.1803C>T	c.(1801-1803)TTC>TTT	p.F601F	CYFIP2_uc011ddn.1_Silent_p.F575F|CYFIP2_uc011ddo.1_Silent_p.F405F|CYFIP2_uc003lwr.2_Silent_p.F601F|CYFIP2_uc003lws.2_Silent_p.F601F|CYFIP2_uc003lwt.2_Silent_p.F504F|CYFIP2_uc011ddp.1_Silent_p.F335F	NM_001037333	NP_001032410	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	626					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding				0	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CCTTCTTCTTCACACATCTGC	0.547		NA											18	7					0	0	0	0
ATP10B	23120	broad.mit.edu	37	5	159992488	159992488	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr5:159992488C>T	uc003lym.1	-	26	5205	c.4358G>A	c.(4357-4359)CGC>CAC	p.R1453H	ATP10B_uc010jit.1_Missense_Mutation_p.R703H	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	1453	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CTGGGATCGGCGATGGCTGCT	0.532		NA											29	66					0	0	0	0
GABRG2	2566	broad.mit.edu	37	5	161569304	161569304	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr5:161569304C>A	uc003lyz.3	+	7	1262	c.904C>A	c.(904-906)CCA>ACA	p.P302T	GABRG2_uc010jjc.2_Missense_Mutation_p.P342T|GABRG2_uc003lyy.3_Missense_Mutation_p.P302T|GABRG2_uc011dej.1_Missense_Mutation_p.P207T	NM_000816	NP_000807	P18507	GBRG2_HUMAN	gamma-aminobutyric acid A receptor, gamma 2	302	Helical; (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(4)|skin(1)	5	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)		GGATGCTGTTCCAGCCAGAAC	0.403		NA											64	22					7.59e-32	8.29e-32	1	0
DOCK2	1794	broad.mit.edu	37	5	169454870	169454870	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr5:169454870G>C	uc003maf.2	+	34	3465	c.3385G>C	c.(3385-3387)GAA>CAA	p.E1129Q	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Missense_Mutation_p.E621Q	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1129	DHR-2.|Interaction with CRKL.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCTTCAGTTTGAAAACGAAAT	0.393		NA											15	43					0	0	0	0
HIVEP1	3096	broad.mit.edu	37	6	12120396	12120396	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr6:12120396C>G	uc003nac.2	+	4	547	c.368C>G	c.(367-369)TCA>TGA	p.S123*	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	123					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				GCTGAAGCCTCAAAATCTGAA	0.433		NA											25	54					0	0	0	0
ACOT13	55856	broad.mit.edu	37	6	24698242	24698242	+	Silent	SNP	T	T	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr6:24698242T>C	uc003nek.2	+	2	442	c.213T>C	c.(211-213)GCT>GCC	p.A71A	ACOT13_uc010jpv.2_Silent_p.A48A	NM_018473	NP_060943	Q9NPJ3	ACO13_HUMAN	acyl-CoA thioesterase 13 isoform 1	71					protein homotetramerization	mitochondrion	acyl-CoA thioesterase activity				0						CAACAATGGCTCTGCTATGCA	0.438		NA											15	41					0	0	0	0
HIST1H3E	8353	broad.mit.edu	37	6	26225674	26225674	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr6:26225674G>A	uc003nhb.2	+	2	652	c.292G>A	c.(292-294)GAG>AAG	p.E98K	HIST1H3E_uc003nhc.3_Missense_Mutation_p.E98K	NM_021018	NP_066298	P68431	H31_HUMAN	histone cluster 1, H3f	98					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding				0		all_hematologic(11;0.0223)|Acute lymphoblastic leukemia(11;0.0351)				GGAGGCCTGCGAGGCCTACTT	0.592		NA									OREG0017240	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	42					0	0	0	0
GABBR1	2550	broad.mit.edu	37	6	29588923	29588923	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr6:29588923C>G	uc003nmt.3	-	11	1614	c.1278G>C	c.(1276-1278)GAG>GAC	p.E426D	GABBR1_uc003nmp.3_Missense_Mutation_p.E309D|GABBR1_uc003nms.3_Missense_Mutation_p.E309D|GABBR1_uc003nmu.3_Missense_Mutation_p.E364D|GABBR1_uc011dlr.1_Missense_Mutation_p.E249D|GABBR1_uc011dls.1_Missense_Mutation_p.E426D	NM_001470	NP_001461	Q9UBS5	GABR1_HUMAN	gamma-aminobutyric acid (GABA) B receptor 1	426	Extracellular (Potential).				gamma-aminobutyric acid signaling pathway|negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|extracellular region|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity			ovary(5)|liver(1)|skin(1)	7					Baclofen(DB00181)|Progabide(DB00837)	GCATGACAATCTCAGTTGTGA	0.532		NA											11	28					0	0	0	0
VARS	7407	broad.mit.edu	37	6	31750118	31750118	+	Silent	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr6:31750118G>C	uc003nxe.2	-	17	2517	c.2094C>G	c.(2092-2094)CTC>CTG	p.L698L	VARS_uc003nxf.1_5'Flank|VARS_uc011doi.1_RNA	NM_006295	NP_006286	P26640	SYVC_HUMAN	valyl-tRNA synthetase	698					translational elongation|valyl-tRNA aminoacylation	cytosol	ATP binding|protein binding|valine-tRNA ligase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3					L-Valine(DB00161)	GCAGGATGCGGAGGTCACCCC	0.667		NA											6	15					0	0	0	0
VARS	7407	broad.mit.edu	37	6	31759748	31759748	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr6:31759748T>G	uc003nxe.2	-	7	1295	c.872A>C	c.(871-873)GAT>GCT	p.D291A	VARS_uc011doi.1_RNA	NM_006295	NP_006286	P26640	SYVC_HUMAN	valyl-tRNA synthetase	291					translational elongation|valyl-tRNA aminoacylation	cytosol	ATP binding|protein binding|valine-tRNA ligase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3					L-Valine(DB00161)	GCCACTGACATCTGGGGGAGA	0.622		NA											3	6					0	0	0	0
ATF6B	1388	broad.mit.edu	37	6	32087660	32087660	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr6:32087660C>T	uc003nzn.2	-	9	940	c.907G>A	c.(907-909)GAG>AAG	p.E303K	TNXB_uc010jts.1_5'Flank|ATF6B_uc003nzm.1_5'Flank|ATF6B_uc003nzo.2_Missense_Mutation_p.E300K|ATF6B_uc003nzp.1_5'UTR	NM_004381	NP_004372	Q99941	ATF6B_HUMAN	activating transcription factor 6 beta isoform	303	Cytoplasmic (Potential).				response to unfolded protein|signal transduction	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CTCTTCCTCTCAGGCCGTGGT	0.592		NA											13	33					0	0	0	0
DNAH8	1769	broad.mit.edu	37	6	38830055	38830055	+	Splice_Site	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr6:38830055G>A	uc003ooe.1	+	42	6081	c.5481_splice	c.e42-1	p.R1827_splice		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						AACATTTGCAGATGCTATATC	0.463		NA											18	34					0	0	0	0
KIF6	221458	broad.mit.edu	37	6	39688494	39688494	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr6:39688494C>T	uc003oot.2	-	2	255	c.160G>A	c.(160-162)GAA>AAA	p.E54K	KIF6_uc011dua.1_Missense_Mutation_p.E54K|KIF6_uc010jxb.1_Missense_Mutation_p.E54K	NM_145027	NP_659464	Q6ZMV9	KIF6_HUMAN	kinesin family member 6	54	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			breast(2)|central_nervous_system(1)	3						TTGTAGCTTTCTCGCTTATTA	0.299		NA											15	25					0	0	0	0
SRF	6722	broad.mit.edu	37	6	43144380	43144380	+	Silent	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr6:43144380C>T	uc003oui.2	+	4	1612	c.1137C>T	c.(1135-1137)CTC>CTT	p.L379L	SRF_uc011dvf.1_Silent_p.L175L	NM_003131	NP_003122	P11831	SRF_HUMAN	serum response factor (c-fos serum response	379					angiogenesis involved in wound healing|cell migration involved in sprouting angiogenesis|cellular senescence|heart looping|muscle cell homeostasis|neuron development|positive regulation of cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription via serum response element binding|regulation of smooth muscle cell differentiation|response to cytokine stimulus|response to hormone stimulus|response to toxin|transcription from RNA polymerase II promoter|trophectodermal cell differentiation	endoplasmic reticulum	protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|serum response element binding|transcription factor binding			ovary(1)|breast(1)|central_nervous_system(1)	3			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.011)|OV - Ovarian serous cystadenocarcinoma(102;0.0423)			GCACAGACCTCACGCAGACCT	0.647		NA											18	81					0	0	0	0
MICAL1	64780	broad.mit.edu	37	6	109771220	109771220	+	Silent	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr6:109771220C>T	uc003ptj.2	-	8	1514	c.1260G>A	c.(1258-1260)GTG>GTA	p.V420V	MICAL1_uc003ptk.2_Silent_p.V420V|MICAL1_uc010kdr.2_Silent_p.V334V|MICAL1_uc011eaq.1_Silent_p.V439V	NM_022765	NP_073602	Q8TDZ2	MICA1_HUMAN	microtubule associated monoxygenase, calponin	420					cytoskeleton organization|signal transduction	cytoplasm|intermediate filament	SH3 domain binding|zinc ion binding			breast(2)|ovary(1)	3		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0142)|all cancers(137;0.0197)|OV - Ovarian serous cystadenocarcinoma(136;0.0233)|BRCA - Breast invasive adenocarcinoma(108;0.0574)		CCCACCGCTTCACCATCCAGG	0.612		NA											25	251					0	0	0	0
LAMA4	3910	broad.mit.edu	37	6	112443245	112443245	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr6:112443245C>G	uc003pvu.2	-	32	4756	c.4447G>C	c.(4447-4449)GAA>CAA	p.E1483Q	LAMA4_uc003pvv.2_Missense_Mutation_p.E1476Q|LAMA4_uc003pvt.2_Missense_Mutation_p.E1476Q	NM_001105206	NP_001098676	Q16363	LAMA4_HUMAN	laminin, alpha 4 isoform 1 precursor	1483	Laminin G-like 4.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		TTTAAGTGTTCAAACTCTTGG	0.443		NA											17	54					0	0	0	0
RSPH4A	345895	broad.mit.edu	37	6	116938128	116938128	+	Silent	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr6:116938128G>C	uc003pxe.2	+	1	487	c.342G>C	c.(340-342)ACG>ACC	p.T114T	RSPH4A_uc010kee.2_Silent_p.T114T	NM_001010892	NP_001010892	Q5TD94	RSH4A_HUMAN	radial spoke head 4 homolog A isoform 1	114					cilium axoneme assembly|cilium movement	cytoplasm|cytoskeleton|radial spoke					0						ACAGGACCACGAGTGTGATTC	0.552		NA							Kartagener_syndrome				18	51					0	0	0	0
FAM184A	79632	broad.mit.edu	37	6	119345734	119345734	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr6:119345734C>G	uc003pyj.2	-	2	752	c.404G>C	c.(403-405)AGA>ACA	p.R135T	FAM184A_uc003pyk.3_Missense_Mutation_p.R15T|FAM184A_uc003pyl.3_Missense_Mutation_p.R15T	NM_024581	NP_078857	Q8NB25	F184A_HUMAN	hypothetical protein LOC79632 isoform 1	135	Potential.									ovary(2)|central_nervous_system(2)|skin(2)|pancreas(1)	7						GTCCTCAACTCTGTGCTTATA	0.378		NA											25	42					0	0	0	0
STX7	8417	broad.mit.edu	37	6	132785161	132785161	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr6:132785161G>A	uc003qdg.2	-	9	914	c.664C>T	c.(664-666)CAG>TAG	p.Q222*	STX7_uc011ecg.1_RNA|STX7_uc011ech.1_Nonsense_Mutation_p.Q47*	NM_003569	NP_003560	O15400	STX7_HUMAN	syntaxin 7	222	t-SNARE coiled-coil homology.|Cytoplasmic (Potential).				intracellular protein transport|post-Golgi vesicle-mediated transport	early endosome membrane|integral to membrane	SNAP receptor activity				0	Breast(56;0.0615)			OV - Ovarian serous cystadenocarcinoma(155;0.00532)|GBM - Glioblastoma multiforme(226;0.0114)		GACAGCTGCTGATTTGCTTGC	0.378		NA											30	101					0	0	0	0
TAAR6	319100	broad.mit.edu	37	6	132892295	132892295	+	Silent	SNP	T	T	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr6:132892295T>C	uc011eck.1	+	1	835	c.835T>C	c.(835-837)TTA>CTA	p.L279L		NM_175067	NP_778237	Q96RI8	TAAR6_HUMAN	trace amine associated receptor 6	279	Extracellular (Potential).					plasma membrane	G-protein coupled receptor activity			ovary(2)|skin(1)	3	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.006)|GBM - Glioblastoma multiforme(226;0.00792)		CATTGATTCATTAATTGATGC	0.408		NA											22	61					0	0	0	0
CCDC28A	25901	broad.mit.edu	37	6	139106386	139106386	+	Silent	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr6:139106386G>A	uc003qie.2	+	4	770	c.615G>A	c.(613-615)CAG>CAA	p.Q205Q		NM_015439	NP_056254	Q8IWP9	CC28A_HUMAN	coiled-coil domain containing 28A	205											0				OV - Ovarian serous cystadenocarcinoma(155;0.000201)|GBM - Glioblastoma multiforme(68;0.000306)		CCATTGAACAGATGGAACATG	0.388		NA											53	45					0	0	0	0
C6orf115	58527	broad.mit.edu	37	6	139363855	139363855	+	Splice_Site	SNP	G	G	C	rs9495322		TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr6:139363855G>C	uc003qil.2	+	3	262	c.62_splice	c.e3-1	p.N21_splice	C6orf115_uc003qim.2_Splice_Site_p.N21_splice	NM_021243	NP_067066	Q9P1F3	CF115_HUMAN	hypothetical protein LOC58527												0				GBM - Glioblastoma multiforme(68;0.000278)|OV - Ovarian serous cystadenocarcinoma(155;0.000413)		TCTCAAACTAGATGCTGATGG	0.358		NA											37	117					0	0	0	0
GPR126	57211	broad.mit.edu	37	6	142718791	142718791	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr6:142718791A>G	uc010khc.2	+	10	1877	c.1466A>G	c.(1465-1467)AAT>AGT	p.N489S	GPR126_uc010khd.2_Missense_Mutation_p.N461S|GPR126_uc010khe.2_Missense_Mutation_p.N489S|GPR126_uc010khf.2_Missense_Mutation_p.N461S	NM_020455	NP_065188	Q86SQ4	GP126_HUMAN	G protein-coupled receptor 126 alpha 1	489	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1	Breast(32;0.176)			OV - Ovarian serous cystadenocarcinoma(155;9.33e-06)|GBM - Glioblastoma multiforme(68;0.00121)		GCTACCAACAATACTAATTTG	0.398		NA											29	23					0	0	0	0
HIVEP2	3097	broad.mit.edu	37	6	143094723	143094723	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr6:143094723G>C	uc003qjd.2	-	5	1896	c.1153C>G	c.(1153-1155)CTC>GTC	p.L385V		NM_006734	NP_006725	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer	385					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		AGAAGGTTGAGCGATGGCTCA	0.438		NA											43	103					0	0	0	0
SYNE1	23345	broad.mit.edu	37	6	152720763	152720763	+	Nonsense_Mutation	SNP	T	T	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr6:152720763T>A	uc010kiw.2	-	48	7827	c.7225A>T	c.(7225-7227)AAA>TAA	p.K2409*	SYNE1_uc003qot.3_Nonsense_Mutation_p.K2416*|SYNE1_uc003qou.3_Nonsense_Mutation_p.K2409*|SYNE1_uc010kjb.1_Nonsense_Mutation_p.K2392*	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2409	Spectrin 4.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTGAAGTGTTTTTCCAGAGAT	0.493		NA								HNSCC(10;0.0054)			138	142					0	0	0	0
SYNE1	23345	broad.mit.edu	37	6	152763259	152763259	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr6:152763259G>T	uc010kiw.2	-	31	4561	c.3959C>A	c.(3958-3960)ACA>AAA	p.T1320K	SYNE1_uc003qot.3_Missense_Mutation_p.T1327K|SYNE1_uc003qou.3_Missense_Mutation_p.T1320K|SYNE1_uc010kjb.1_Missense_Mutation_p.T1303K|SYNE1_uc003qow.2_Missense_Mutation_p.T615K|SYNE1_uc003qox.1_Missense_Mutation_p.T836K	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1320	Potential.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GCCATCCAGTGTGCTCTCCAG	0.637		NA								HNSCC(10;0.0054)			17	53					3.67e-16	3.98e-16	1	0
SYNE1	23345	broad.mit.edu	37	6	152841605	152841605	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr6:152841605C>T	uc010kiw.2	-	6	900	c.298G>A	c.(298-300)GAA>AAA	p.E100K	SYNE1_uc003qot.3_Missense_Mutation_p.E100K|SYNE1_uc003qou.3_Missense_Mutation_p.E100K|SYNE1_uc010kjb.1_Missense_Mutation_p.E100K|SYNE1_uc003qpa.1_Missense_Mutation_p.E100K	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	100	Actin-binding.|Cytoplasmic (Potential).|CH 1.				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TTTCTTCCTTCGAGGAACTTG	0.443		NA								HNSCC(10;0.0054)			40	137					0	0	0	0
FNDC1	84624	broad.mit.edu	37	6	159653679	159653679	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr6:159653679C>T	uc010kjv.2	+	11	2335	c.2135C>T	c.(2134-2136)GCC>GTC	p.A712V	FNDC1_uc010kjw.1_Missense_Mutation_p.A597V	NM_032532	NP_115921	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	712	Ser-rich.					extracellular region				large_intestine(4)|ovary(3)|central_nervous_system(1)	8		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		GATTCCAGTGCCTCAGCCCCA	0.657		NA											8	12					0	0	0	0
SLC22A3	6581	broad.mit.edu	37	6	160857877	160857877	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr6:160857877G>C	uc003qti.2	+	6	1068	c.1041G>C	c.(1039-1041)ATG>ATC	p.M347I	SLC22A3_uc011efx.1_Intron	NM_021977	NP_068812	O75751	S22A3_HUMAN	solute carrier family 22 member 3	347						integral to plasma membrane|membrane fraction	protein binding|quaternary ammonium group transmembrane transporter activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Breast(66;0.00028)|Ovarian(120;0.0308)|Prostate(117;0.218)		OV - Ovarian serous cystadenocarcinoma(65;9.47e-17)|BRCA - Breast invasive adenocarcinoma(81;9.75e-06)		CTCCCCAAATGAGGAAATGCA	0.348		NA											16	33					0	0	0	0
SLC22A3	6581	broad.mit.edu	37	6	160864770	160864770	+	Silent	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr6:160864770C>T	uc003qti.2	+	9	1533	c.1506C>T	c.(1504-1506)ATC>ATT	p.I502I	SLC22A3_uc011efx.1_RNA	NM_021977	NP_068812	O75751	S22A3_HUMAN	solute carrier family 22 member 3	502	Helical; (Potential).					integral to plasma membrane|membrane fraction	protein binding|quaternary ammonium group transmembrane transporter activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Breast(66;0.00028)|Ovarian(120;0.0308)|Prostate(117;0.218)		OV - Ovarian serous cystadenocarcinoma(65;9.47e-17)|BRCA - Breast invasive adenocarcinoma(81;9.75e-06)		CTCTGATCATCTTTGGTAAGA	0.393		NA											32	21					0	0	0	0
THBS2	7058	broad.mit.edu	37	6	169640633	169640633	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr6:169640633T>G	uc003qwt.2	-	7	1194	c.946A>C	c.(946-948)AAC>CAC	p.N316H		NM_003247	NP_003238	P35442	TSP2_HUMAN	thrombospondin 2 precursor	316					cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			ovary(5)	5		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		GCTGACATGTTCCTTGTCTTA	0.483		NA											27	24					0	0	0	0
ETV1	2115	broad.mit.edu	37	7	13946217	13946217	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr7:13946217G>C	uc011jxq.1	-	12	1687	c.948C>G	c.(946-948)ATC>ATG	p.I316M	ETV1_uc011jxn.1_Missense_Mutation_p.I276M|ETV1_uc011jxo.1_Missense_Mutation_p.I213M|ETV1_uc011jxp.1_Missense_Mutation_p.I258M|ETV1_uc003ssw.3_Missense_Mutation_p.I293M|ETV1_uc003ssx.2_RNA|ETV1_uc011jxr.1_Missense_Mutation_p.I298M|ETV1_uc011jxs.1_Missense_Mutation_p.I298M|ETV1_uc010ktv.2_Nonsense_Mutation_p.S185*	NM_004956	NP_004947	P50549	ETV1_HUMAN	ets variant gene 1 isoform a	316					transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		TMPRSS2/ETV1(24)|EWSR1/ETV1(7)	prostate(24)|soft_tissue(4)|bone(3)|lung(2)|central_nervous_system(1)|ovary(1)	35						GCTCTTGTTTGATGTCTCCTA	0.368		NA	T	EWSR1|TMPRSS2|SLC45A3|C15orf21|HNRNPA2B1. ACSL3	Ewing sarcoma|prostate								3	11					0	0	0	0
AGR3	155465	broad.mit.edu	37	7	16902261	16902261	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr7:16902261G>A	uc003sts.2	-	4	272	c.199C>T	c.(199-201)CAC>TAC	p.H67Y		NM_176813	NP_789783	Q8TD06	AGR3_HUMAN	breast cancer membrane protein 11 precursor	67						extracellular region					0	Lung NSC(10;0.0376)|all_lung(11;0.0721)|all_epithelial(12;0.202)			UCEC - Uterine corpus endometrioid carcinoma (126;0.184)		TCCTCCAGGTGATGAATAACC	0.284		NA											17	86					0	0	0	0
ABCB5	340273	broad.mit.edu	37	7	20762686	20762686	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr7:20762686G>T	uc003suw.3	+	12	1680	c.1134G>T	c.(1132-1134)ATG>ATT	p.M378I	ABCB5_uc010kuh.2_Missense_Mutation_p.M823I|ABCB5_uc003sux.1_Missense_Mutation_p.M1I	NM_178559	NP_848654	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B, member 5	378	Extracellular (Potential).|ABC transmembrane type-1.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			skin(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|pancreas(1)	6						CAACTAACATGGGACTTTCAG	0.378		NA											37	77					5.72e-15	6.19e-15	1	0
DNAH11	8701	broad.mit.edu	37	7	21599363	21599363	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr7:21599363G>C	uc003svc.2	+	4	866	c.835G>C	c.(835-837)GAT>CAT	p.D279H		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	279	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						AGCAGAACTAGATTTCTGGAT	0.358		NA							Kartagener_syndrome				7	8					0	0	0	0
BBS9	27241	broad.mit.edu	37	7	33388766	33388766	+	Silent	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr7:33388766C>T	uc003tdn.1	+	13	1929	c.1416C>T	c.(1414-1416)TTC>TTT	p.F472F	BBS9_uc003tdo.1_Silent_p.F472F|BBS9_uc003tdp.1_Silent_p.F472F|BBS9_uc003tdq.1_Silent_p.F472F|BBS9_uc010kwn.1_RNA|BBS9_uc003tdr.1_5'UTR|BBS9_uc003tds.1_5'Flank|BBS9_uc011kao.1_Silent_p.F350F	NM_198428	NP_940820	Q3SYG4	PTHB1_HUMAN	parathyroid hormone-responsive B1 isoform 2	472					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			GBM - Glioblastoma multiforme(11;0.0894)			GTGATCAGTTCACCTTTGAAT	0.333		NA							Bardet-Biedl_syndrome				14	76					0	0	0	0
BMPER	168667	broad.mit.edu	37	7	34118611	34118611	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr7:34118611C>G	uc011kap.1	+	12	1335	c.1221C>G	c.(1219-1221)AAC>AAG	p.N407K		NM_133468	NP_597725	Q8N8U9	BMPER_HUMAN	BMP-binding endothelial regulator precursor	407	VWFD.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				ovary(2)|central_nervous_system(1)	3						TGGTGAAGAACGACGCCCGCC	0.607		NA											49	88					0	0	0	0
VPS41	27072	broad.mit.edu	37	7	38812139	38812139	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr7:38812139C>G	uc003tgy.2	-	13	1137	c.1111G>C	c.(1111-1113)GAA>CAA	p.E371Q	VPS41_uc003tgz.2_Missense_Mutation_p.E346Q|VPS41_uc010kxn.2_Missense_Mutation_p.E282Q	NM_014396	NP_055211	P49754	VPS41_HUMAN	vacuolar protein sorting 41 isoform 1	371					Golgi vesicle transport|intracellular protein transport|vesicle-mediated transport	cytosol|Golgi-associated vesicle|HOPS complex|membrane fraction	zinc ion binding			skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4						TTCTTCTTTTCAAGGAGCCAG	0.363		NA											9	40					0	0	0	0
TNS3	64759	broad.mit.edu	37	7	47319949	47319949	+	Silent	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr7:47319949G>C	uc003tnv.2	-	29	4468	c.4101C>G	c.(4099-4101)CTC>CTG	p.L1367L	TNS3_uc003tnw.2_Silent_p.L1367L	NM_022748	NP_073585	Q68CZ2	TENS3_HUMAN	tensin 3	1367						focal adhesion	protein binding			ovary(4)	4						TCCGGAAGAAGAGCCTGTTGG	0.502		NA											8	37					0	0	0	0
IKZF1	10320	broad.mit.edu	37	7	50450284	50450284	+	Silent	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr7:50450284G>A	uc003tow.3	+	6	636	c.468G>A	c.(466-468)CAG>CAA	p.Q156Q	IKZF1_uc003tox.3_Silent_p.Q156Q|IKZF1_uc003toy.3_Silent_p.Q156Q|IKZF1_uc011kck.1_Silent_p.Q69Q|IKZF1_uc003toz.3_Silent_p.Q126Q|IKZF1_uc010kyx.2_Intron	NM_006060	NP_006051	Q13422	IKZF1_HUMAN	zinc finger protein, subfamily 1A, 1 (Ikaros)	156	Required for both high-affinity DNA binding and pericentromeric heterochromatin localization (By similarity).|C2H2-type 2.				cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding	p.?(74)		haematopoietic_and_lymphoid_tissue(147)|lung(1)	148	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				CATTCACCCAGAAGGGCAACC	0.612		NA	D		ALL								5	25					0	0	0	0
COBL	23242	broad.mit.edu	37	7	51261114	51261114	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr7:51261114C>T	uc003tpr.3	-	3	603	c.418G>A	c.(418-420)GAA>AAA	p.E140K	COBL_uc003tps.2_Missense_Mutation_p.E140K|COBL_uc011kcl.1_Missense_Mutation_p.E140K|COBL_uc010kzc.2_Missense_Mutation_p.E140K|COBL_uc003tpt.2_Missense_Mutation_p.E140K|COBL_uc003tpp.3_5'Flank|COBL_uc003tpq.3_Missense_Mutation_p.E56K	NM_015198	NP_056013	O75128	COBL_HUMAN	cordon-bleu homolog	140										skin(3)|ovary(2)	5	Glioma(55;0.08)					ACCTTCTCTTCAGGAACTTTT	0.453		NA											14	77					0	0	0	0
AUTS2	26053	broad.mit.edu	37	7	70252204	70252204	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr7:70252204C>G	uc003tvw.3	+	18	3061	c.2318C>G	c.(2317-2319)TCA>TGA	p.S773*	AUTS2_uc003tvx.3_Nonsense_Mutation_p.S749*|AUTS2_uc011keg.1_Nonsense_Mutation_p.S225*	NM_015570	NP_056385	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2 isoform 1	773										ovary(2)|central_nervous_system(1)	3		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		GCACCCAACTCAATGTTCGGC	0.473		NA											7	21					0	0	0	0
SEMA3A	10371	broad.mit.edu	37	7	83610791	83610791	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr7:83610791G>T	uc003uhz.2	-	14	1813	c.1498C>A	c.(1498-1500)CAA>AAA	p.Q500K		NM_006080	NP_006071	Q14563	SEM3A_HUMAN	semaphorin 3A precursor	500	Sema.				axon guidance	extracellular region|membrane	receptor activity			ovary(2)|breast(1)|kidney(1)	4						ATATATAGTTGTTGCTGTGGA	0.418		NA											4	9					2.56e-06	2.7e-06	1	0
MTERF	7978	broad.mit.edu	37	7	91503289	91503289	+	Silent	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr7:91503289C>G	uc003ulb.1	-	2	863	c.819G>C	c.(817-819)CTG>CTC	p.L273L	MTERF_uc010let.1_Intron|MTERF_uc003ulc.1_Silent_p.L273L|MTERF_uc011khm.1_Silent_p.L253L|MTERF_uc010leu.1_Silent_p.L253L	NM_006980	NP_008911	Q99551	MTERF_HUMAN	mitochondrial transcription termination factor	273					DNA geometric change|regulation of transcription, DNA-dependent|termination of mitochondrial transcription	mitochondrial nucleoid	double-stranded DNA binding				0	all_cancers(62;2.28e-09)|all_epithelial(64;1.07e-07)|Breast(17;0.00371)|all_hematologic(106;0.091)|all_lung(186;0.178)|Lung NSC(181;0.235)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.0993)|Kidney(17;0.118)|Epithelial(20;0.136)|LUSC - Lung squamous cell carcinoma(200;0.176)			GACCACATATCAGAACCAGCA	0.413		NA											10	46					0	0	0	0
CALCR	799	broad.mit.edu	37	7	93098029	93098029	+	Silent	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr7:93098029G>A	uc003umv.1	-	7	834	c.573C>T	c.(571-573)TTC>TTT	p.F191F	CALCR_uc003ums.1_RNA|CALCR_uc003umt.1_RNA|CALCR_uc003umu.1_Silent_p.F173F|CALCR_uc003umw.2_Silent_p.F173F	NM_001742	NP_001733	P30988	CALCR_HUMAN	calcitonin receptor isoform 2 precursor	173	Helical; Name=1; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin binding|calcitonin receptor activity|calcitonin receptor activity|protein binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	GTACTTACCTGAAAAACACGA	0.418		NA											6	38					0	0	0	0
COL1A2	1278	broad.mit.edu	37	7	94052411	94052411	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr7:94052411C>T	uc003ung.1	+	40	3017	c.2546C>T	c.(2545-2547)TCT>TTT	p.S849F	COL1A2_uc011kib.1_Intron|COL1A2_uc010lfi.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	849			Missing (in OI2A).		axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	AAGGGTCCCTCTGGAGAGGCT	0.507		NA								HNSCC(75;0.22)			15	91					0	0	0	0
C7orf43	55262	broad.mit.edu	37	7	99753354	99753354	+	Silent	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr7:99753354C>T	uc003utr.2	-	9	1515	c.1335G>A	c.(1333-1335)CGG>CGA	p.R445R	C7orf43_uc010lgo.2_Silent_p.R71R|C7orf43_uc010lgp.2_Silent_p.R67R|C7orf43_uc011kjj.1_Silent_p.R213R|C7orf43_uc003uts.2_Silent_p.R176R	NM_018275	NP_060745	Q8WVR3	CG043_HUMAN	hypothetical protein LOC55262	445											0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CGCTGCCCTTCCGGGAAAAGC	0.657		NA											30	120					0	0	0	0
PSMC2	5701	broad.mit.edu	37	7	103006550	103006550	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr7:103006550G>C	uc003vbs.2	+	9	854	c.784G>C	c.(784-786)GAA>CAA	p.E262Q	SLC26A5_uc003vbt.1_Intron|SLC26A5_uc003vbu.1_Intron|SLC26A5_uc003vbv.1_Intron|PSMC2_uc011klo.1_Missense_Mutation_p.E125Q	NM_002803	NP_002794	P35998	PRS7_HUMAN	proteasome 26S ATPase subunit 2	262					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	mitochondrion|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding				0						TGAACTCTTTGAAATGGCCAG	0.323		NA											40	51					0	0	0	0
RELN	5649	broad.mit.edu	37	7	103155675	103155675	+	Silent	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr7:103155675G>A	uc003vca.2	-	50	8236	c.8076C>T	c.(8074-8076)GTC>GTT	p.V2692V	RELN_uc010liz.2_Silent_p.V2692V	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	2692					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CGATCCTCCCGACAGGGCCGG	0.517		NA											6	39					0	0	0	0
EXOC4	60412	broad.mit.edu	37	7	133059592	133059592	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr7:133059592G>A	uc003vrk.2	+	7	1053	c.1018G>A	c.(1018-1020)GAA>AAA	p.E340K	EXOC4_uc011kpo.1_Missense_Mutation_p.E239K|EXOC4_uc003vri.2_Missense_Mutation_p.E340K|EXOC4_uc003vrj.2_Missense_Mutation_p.E340K	NM_021807	NP_068579	Q96A65	EXOC4_HUMAN	SEC8 protein isoform a	340					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			ovary(4)|large_intestine(3)|upper_aerodigestive_tract(1)|skin(1)	9		Esophageal squamous(399;0.129)				GTTGCTTCTAGAACTGCTGGA	0.423		NA											17	39					0	0	0	0
ZC3HAV1	56829	broad.mit.edu	37	7	138764323	138764323	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr7:138764323C>G	uc003vun.2	-	4	1752	c.1364G>C	c.(1363-1365)AGA>ACA	p.R455T	ZC3HAV1_uc003vuo.2_5'Flank|ZC3HAV1_uc003vup.2_Missense_Mutation_p.R455T	NM_020119	NP_064504	Q7Z2W4	ZCCHV_HUMAN	zinc finger antiviral protein isoform 1	455					response to virus	cytoplasm|nucleus	NAD+ ADP-ribosyltransferase activity|RNA binding|zinc ion binding			ovary(1)	1						TGATATTTCTCTGTGACCGCT	0.468		NA											24	41					0	0	0	0
ZNF212	7988	broad.mit.edu	37	7	148947893	148947893	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr7:148947893C>G	uc003wfp.2	+	3	632	c.536C>G	c.(535-537)TCT>TGT	p.S179C		NM_012256	NP_036388	Q9UDV6	ZN212_HUMAN	zinc finger protein 212	179	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|identical protein binding|zinc ion binding			ovary(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)			ACACTGGTCTCTCTGAGTGAG	0.498		NA											19	44					0	0	0	0
SOX7	83595	broad.mit.edu	37	8	10683716	10683716	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr8:10683716C>T	uc011kwz.1	-	5	373	c.340G>A	c.(340-342)GAG>AAG	p.E114K	PINX1_uc003wth.2_Missense_Mutation_p.E114K|PINX1_uc003wti.2_Missense_Mutation_p.E114K|MIR1322_hsa-mir-1322|MI0006653_5'Flank	NM_031439	NP_113627	Q9BT81	SOX7_HUMAN	SRY-box 7	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					endoderm formation|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|positive regulation of caspase activity|regulation of canonical Wnt receptor signaling pathway	cytoplasm|nucleus	transcription regulatory region DNA binding			breast(1)	1				COAD - Colon adenocarcinoma(149;0.0732)		GACTTTTCCTCAAGGCTAAAA	0.299		NA											12	6					0	0	0	0
SGCZ	137868	broad.mit.edu	37	8	14022158	14022158	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr8:14022158C>T	uc003wwq.2	-	5	1138	c.478G>A	c.(478-480)GAT>AAT	p.D160N	SGCZ_uc010lss.2_Missense_Mutation_p.D113N	NM_139167	NP_631906	Q96LD1	SGCZ_HUMAN	sarcoglycan zeta	147	Extracellular (Potential).				cytoskeleton organization	cytoplasm|cytoskeleton|integral to membrane|sarcolemma				ovary(2)|central_nervous_system(1)	3				all cancers(2;0.000643)|Colorectal(111;0.00674)|COAD - Colon adenocarcinoma(73;0.0193)|GBM - Glioblastoma multiforme(2;0.026)		ACCCTGCCATCTTCACTGGCT	0.423		NA											14	29					0	0	0	0
RP1	6101	broad.mit.edu	37	8	55537868	55537868	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr8:55537868C>G	uc003xsd.1	+	4	1574	c.1426C>G	c.(1426-1428)CAA>GAA	p.Q476E	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	476					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			AACTGAGGTTCAAGAGAAAAT	0.388		NA											18	45					0	0	0	0
RPS20	6224	broad.mit.edu	37	8	56985678	56985678	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr8:56985678C>T	uc003xsn.2	-	4	529	c.331G>A	c.(331-333)GAG>AAG	p.E111K	RPS20_uc003xsm.2_Missense_Mutation_p.E111K	NM_001023	NP_001014	P60866	RS20_HUMAN	ribosomal protein S20 isoform 2	111					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome				0		all_lung(136;0.0548)|Lung NSC(129;0.0718)|all_epithelial(80;0.155)	Epithelial(17;0.00117)|all cancers(17;0.00879)			ACTTCCACCTCAACTCCTGGC	0.388		NA											18	33					0	0	0	0
RRS1	23212	broad.mit.edu	37	8	67341837	67341837	+	Silent	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr8:67341837G>A	uc003xwa.2	+	1	575	c.471G>A	c.(469-471)CTG>CTA	p.L157L	ADHFE1_uc003xwb.3_5'Flank|ADHFE1_uc003xwd.3_5'Flank|ADHFE1_uc003xwc.3_5'Flank|ADHFE1_uc003xwe.3_5'Flank|ADHFE1_uc003xwf.3_5'Flank|ADHFE1_uc011les.1_5'Flank|ADHFE1_uc011leq.1_5'Flank|ADHFE1_uc011ler.1_5'Flank	NM_015169	NP_055984	Q15050	RRS1_HUMAN	homolog of yeast ribosome biogenesis regulatory	157					mitotic metaphase plate congression|ribosome biogenesis	condensed nuclear chromosome|nucleolus					0		Lung NSC(129;0.197)	Epithelial(68;0.0391)|all cancers(69;0.0898)|BRCA - Breast invasive adenocarcinoma(89;0.111)|OV - Ovarian serous cystadenocarcinoma(28;0.226)			AAGAATGGCTGATTGAGGTGC	0.637		NA											13	19					0	0	0	0
CA3	761	broad.mit.edu	37	8	86360296	86360296	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr8:86360296G>A	uc003ydj.2	+	7	780	c.697G>A	c.(697-699)GAG>AAG	p.E233K	CA3_uc011lfv.1_RNA	NM_005181	NP_005172	P07451	CAH3_HUMAN	carbonic anhydrase III	233					one-carbon metabolic process	cytoplasm	carbonate dehydratase activity|zinc ion binding				0						CTCCAGTGCTGAGAACGAGCC	0.542		NA											14	17					0	0	0	0
SDC2	6383	broad.mit.edu	37	8	97620608	97620608	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr8:97620608G>C	uc003yhv.1	+	4	970	c.352G>C	c.(352-354)GAA>CAA	p.E118Q	SDC2_uc011lgu.1_Missense_Mutation_p.E89Q	NM_002998	NP_002989	P34741	SDC2_HUMAN	syndecan 2 precursor	118	Extracellular (Potential).					integral to plasma membrane	cytoskeletal protein binding|PDZ domain binding			ovary(2)	2	Breast(36;3.41e-05)				Sargramostim(DB00020)	CTCTGACTCAGAAAGGAAAAT	0.418		NA											7	28					0	0	0	0
SYBU	55638	broad.mit.edu	37	8	110655123	110655123	+	Silent	SNP	A	A	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr8:110655123A>G	uc003ynj.3	-	2	226	c.63T>C	c.(61-63)TCT>TCC	p.S21S	SYBU_uc003yni.3_Silent_p.S18S|SYBU_uc003ynk.3_Intron|SYBU_uc010mco.2_Silent_p.S20S|SYBU_uc003ynl.3_Silent_p.S20S|SYBU_uc010mcp.2_Silent_p.S21S|SYBU_uc010mcq.2_Silent_p.S21S|SYBU_uc003yno.3_Intron|SYBU_uc010mcr.2_Silent_p.S21S|SYBU_uc003ynm.3_Silent_p.S20S|SYBU_uc003ynn.3_Silent_p.S20S|SYBU_uc010mcs.2_Intron|SYBU_uc010mct.2_Silent_p.S21S|SYBU_uc010mcu.2_Silent_p.S20S|SYBU_uc003ynp.3_Intron|SYBU_uc010mcv.2_Silent_p.S21S|uc003ynq.1_5'Flank	NM_001099754	NP_001093224	Q9NX95	SYBU_HUMAN	Golgi-localized syntaphilin-related protein	21	Sufficient for interaction with KIF5B.					cytoplasmic membrane-bounded vesicle|cytoskeleton|Golgi membrane|integral to membrane				ovary(1)	1						TTCGGCTTCGAGAAATCTCCT	0.478		NA											21	45					0	0	0	0
TNFRSF11B	4982	broad.mit.edu	37	8	119945204	119945204	+	Silent	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr8:119945204C>T	uc003yon.3	-	2	689	c.366G>A	c.(364-366)AGG>AGA	p.R122R	TNFRSF11B_uc010mdc.1_RNA	NM_002546	NP_002537	O00300	TR11B_HUMAN	osteoprotegerin precursor	122	TNFR-Cys 3.				apoptosis|skeletal system development		cytokine activity|receptor activity			central_nervous_system(2)	2	all_cancers(13;3.71e-26)|Lung NSC(37;1.69e-07)|Ovarian(258;0.018)|all_neural(195;0.0592)|Hepatocellular(40;0.234)		STAD - Stomach adenocarcinoma(47;0.00193)			GAGGGCAGCTCCTATGTTTCA	0.493		NA											11	31					0	0	0	0
TOP1MT	116447	broad.mit.edu	37	8	144413487	144413487	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr8:144413487C>T	uc003yxz.2	-	2	164	c.145G>A	c.(145-147)GAC>AAC	p.D49N	TOP1MT_uc011lkd.1_5'UTR|TOP1MT_uc011lke.1_5'UTR|TOP1MT_uc010mfb.2_5'UTR|TOP1MT_uc010mfd.1_5'UTR	NM_052963	NP_443195	Q969P6	TOP1M_HUMAN	mitochondrial topoisomerase I precursor	49					DNA topological change	chromosome|mitochondrial nucleoid	ATP binding|chromatin DNA binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA topoisomerase type I activity			ovary(1)	1	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)		Irinotecan(DB00762)|Topotecan(DB01030)	TTCACCCCGTCTTCGTGCTTC	0.607		NA											35	17					0	0	0	0
ZNF251	90987	broad.mit.edu	37	8	145948062	145948062	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr8:145948062C>T	uc003zdv.3	-	5	1239	c.983G>A	c.(982-984)AGA>AAA	p.R328K		NM_138367	NP_612376	Q9BRH9	ZN251_HUMAN	zinc finger protein 251	328	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.54e-11)|all_epithelial(106;2.65e-10)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.75e-39)|Epithelial(56;7.54e-38)|all cancers(56;6.19e-33)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.11)	GBM - Glioblastoma multiforme(99;0.198)		GCTAAAGCCTCTTCCACATTC	0.488		NA											17	11					0	0	0	0
ZNF251	90987	broad.mit.edu	37	8	145948232	145948232	+	Silent	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr8:145948232C>T	uc003zdv.3	-	5	1069	c.813G>A	c.(811-813)GGG>GGA	p.G271G		NM_138367	NP_612376	Q9BRH9	ZN251_HUMAN	zinc finger protein 251	271	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.54e-11)|all_epithelial(106;2.65e-10)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.75e-39)|Epithelial(56;7.54e-38)|all cancers(56;6.19e-33)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.11)	GBM - Glioblastoma multiforme(99;0.198)		CAAAAGTTTTCCCACATTCAT	0.453		NA											26	21					0	0	0	0
ZNF16	7564	broad.mit.edu	37	8	146157372	146157372	+	Silent	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr8:146157372G>A	uc003zet.2	-	4	988	c.801C>T	c.(799-801)TGC>TGT	p.C267C	ZNF16_uc003zeu.2_Silent_p.C267C	NM_001029976	NP_001025147	P17020	ZNF16_HUMAN	zinc finger protein 16	267	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;0.136)	Epithelial(56;3.45e-38)|all cancers(56;3.04e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0424)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.02)|KIRC - Kidney renal clear cell carcinoma(644;0.0486)		CACATTCGCTGCACTGGTAAG	0.453		NA											4	94					0	0	0	0
KIAA2026	158358	broad.mit.edu	37	9	6007497	6007497	+	Silent	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr9:6007497G>A	uc003zjq.3	-	1	507	c.291C>T	c.(289-291)CTC>CTT	p.L97L		NM_001017969	NP_001017969	Q5HYC2	K2026_HUMAN	hypothetical protein LOC158358	97										ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		AGGGGGCGGTGAGGCCCCGGT	0.716		NA											11	60					0	0	0	0
BNC2	54796	broad.mit.edu	37	9	16436013	16436013	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr9:16436013C>G	uc003zml.2	-	6	2319	c.2179G>C	c.(2179-2181)GAG>CAG	p.E727Q	BNC2_uc011lmw.1_Missense_Mutation_p.E632Q|BNC2_uc003zmm.2_Missense_Mutation_p.E685Q|BNC2_uc003zmq.1_Missense_Mutation_p.E741Q|BNC2_uc003zmr.1_Missense_Mutation_p.E764Q|BNC2_uc003zmp.1_Missense_Mutation_p.E755Q|BNC2_uc010mij.1_Missense_Mutation_p.E649Q|BNC2_uc011lmv.1_Missense_Mutation_p.E553Q|BNC2_uc003zmo.1_Missense_Mutation_p.E649Q|BNC2_uc003zmj.2_Missense_Mutation_p.E492Q|BNC2_uc003zmk.2_RNA|BNC2_uc003zmi.2_Missense_Mutation_p.E492Q|BNC2_uc003zmn.1_Missense_Mutation_p.E492Q	NM_017637	NP_060107	Q6ZN30	BNC2_HUMAN	basonuclin 2	727					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(50;9.01e-08)		TCCGAAGACTCAGACTCGTTC	0.512		NA											155	44					0	0	0	0
HAUS6	54801	broad.mit.edu	37	9	19058235	19058235	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr9:19058235G>C	uc003znk.2	-	16	2783	c.2530C>G	c.(2530-2532)CTT>GTT	p.L844V	HAUS6_uc011lmz.1_Missense_Mutation_p.L564V|HAUS6_uc003znl.1_Missense_Mutation_p.L708V	NM_017645	NP_060115	Q7Z4H7	HAUS6_HUMAN	HAUS augmin-like complex, subunit 6	844					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|nucleus|spindle				ovary(2)	2						TTCTTGGAAAGAGATTTCTTC	0.433		NA											29	353					0	0	0	0
MLLT3	4300	broad.mit.edu	37	9	20414373	20414373	+	Silent	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr9:20414373G>A	uc003zoe.2	-	5	730	c.471C>T	c.(469-471)AGC>AGT	p.S157S	MLLT3_uc011lne.1_Silent_p.S125S|MLLT3_uc011lnf.1_Silent_p.S154S|MLLT3_uc003zof.2_5'UTR|MLLT3_uc011lng.1_Intron	NM_004529	NP_004520	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	157	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(2)|ovary(1)	3				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctgctactgctgc	0.134		NA	T	MLL	ALL								4	50					0	0	0	0
PIGO	84720	broad.mit.edu	37	9	35092757	35092757	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr9:35092757C>T	uc003zwd.2	-	7	1523	c.1127G>A	c.(1126-1128)CGA>CAA	p.R376Q	PIGO_uc003zwc.1_3'UTR|PIGO_uc003zwe.2_Missense_Mutation_p.R376Q|PIGO_uc003zwf.2_Missense_Mutation_p.R376Q|PIGO_uc003zwg.1_5'UTR	NM_032634	NP_116023	Q8TEQ8	PIGO_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	376					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	transferase activity			large_intestine(1)|ovary(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			ATGAAGAAATCGGGACACCTG	0.512		NA											25	17					0	0	0	0
FAM75A6	389730	broad.mit.edu	37	9	43627116	43627116	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr9:43627116G>A	uc011lrb.1	-	4	1600	c.1571C>T	c.(1570-1572)TCG>TTG	p.S524L		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	524						integral to membrane					0						TTTATTCTGCGATGCAGGGCA	0.507		NA											70	336					0	0	0	0
CBWD6	644019	broad.mit.edu	37	9	69247529	69247529	+	Silent	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr9:69247529G>A	uc004afj.3	-	5	589	c.483C>T	c.(481-483)TAC>TAT	p.Y161Y	CBWD6_uc004afk.3_Intron|CBWD6_uc011lrf.1_Intron	NM_001085457	NP_001078926	Q4V339	CBWD6_HUMAN	COBW domain containing 6	161							ATP binding				0						TACCATCAAGGTAAATATCAC	0.214		NA											3	30					0	0	0	0
TMEM2	23670	broad.mit.edu	37	9	74347373	74347373	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr9:74347373C>G	uc011lsa.1	-	7	1997	c.1457G>C	c.(1456-1458)GGA>GCA	p.G486A	TMEM2_uc010mos.2_Missense_Mutation_p.G423A|TMEM2_uc011lsb.1_RNA	NM_013390	NP_037522	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2 isoform a	486						integral to membrane				ovary(2)	2		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		GGTAAGAATTCCAACCTCAGC	0.428		NA											21	54					0	0	0	0
SECISBP2	79048	broad.mit.edu	37	9	91963111	91963111	+	Missense_Mutation	SNP	G	G	A	rs147681365		TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr9:91963111G>A	uc004aqj.1	+	12	1800	c.1720G>A	c.(1720-1722)GAG>AAG	p.E574K	SECISBP2_uc011ltk.1_Missense_Mutation_p.E573K|SECISBP2_uc004aqk.1_Missense_Mutation_p.E501K|SECISBP2_uc010mqo.1_Missense_Mutation_p.E279K|SECISBP2_uc011ltl.1_Missense_Mutation_p.E506K	NM_024077	NP_076982	Q96T21	SEBP2_HUMAN	SECIS binding protein 2	574					translation	nucleus	mRNA 3'-UTR binding			ovary(2)|skin(1)	3						CCAGTTTCCCGAGCAGGCAGA	0.463		NA											19	71					0	0	0	0
SEMA4D	10507	broad.mit.edu	37	9	92003801	92003801	+	Silent	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr9:92003801G>A	uc004aqo.1	-	12	1508	c.936C>T	c.(934-936)CTC>CTT	p.L312L	SEMA4D_uc011ltm.1_Silent_p.L312L|SEMA4D_uc011ltn.1_RNA|SEMA4D_uc011lto.1_RNA|SEMA4D_uc004aqp.1_Silent_p.L310L	NM_006378	NP_006369	Q92854	SEM4D_HUMAN	semaphorin 4D isoform 1	312	Sema.|Extracellular (Potential).				anti-apoptosis|axon guidance|cell adhesion|immune response	integral to membrane|plasma membrane	receptor activity|receptor binding			ovary(1)|pancreas(1)	2						GTGGGGTGAAGAGTGCATAGA	0.617		NA											26	95					0	0	0	0
SEMA4D	10507	broad.mit.edu	37	9	92017921	92017921	+	Silent	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr9:92017921C>T	uc004aqo.1	-	6	689	c.117G>A	c.(115-117)CTG>CTA	p.L39L	SEMA4D_uc011ltm.1_Silent_p.L39L|SEMA4D_uc011ltn.1_RNA|SEMA4D_uc011lto.1_RNA|SEMA4D_uc004aqp.1_Silent_p.L37L	NM_006378	NP_006369	Q92854	SEM4D_HUMAN	semaphorin 4D isoform 1	39	Sema.|Extracellular (Potential).				anti-apoptosis|axon guidance|cell adhesion|immune response	integral to membrane|plasma membrane	receptor activity|receptor binding			ovary(1)|pancreas(1)	2						GAAACTGCACCAGGTGCACCT	0.547		NA											10	48					0	0	0	0
SYK	6850	broad.mit.edu	37	9	93650072	93650072	+	Silent	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr9:93650072G>A	uc004aqz.2	+	12	1828	c.1623G>A	c.(1621-1623)CCG>CCA	p.P541P	SYK_uc004ara.2_Silent_p.P518P|SYK_uc004arb.2_Silent_p.P518P|SYK_uc004arc.2_Silent_p.P541P|SYK_uc011ltr.1_RNA|SYK_uc011lts.1_RNA|SYK_uc011ltt.1_RNA	NM_003177	NP_003168	P43405	KSYK_HUMAN	spleen tyrosine kinase isoform 1	541	Protein kinase.				cell proliferation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|neutrophil chemotaxis|organ morphogenesis|platelet activation|protein complex assembly	cytosol|T cell receptor complex	ATP binding|integrin binding|non-membrane spanning protein tyrosine kinase activity			lung(2)|stomach(1)|ovary(1)|skin(1)	5						GGTACGCTCCGGAATGCATCA	0.438		NA	T	ETV6|ITK	MDS|peripheral T-cell lymphoma								7	164					0	0	0	0
NOL8	55035	broad.mit.edu	37	9	95062221	95062221	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr9:95062221C>G	uc004arv.2	-	14	3590	c.3253G>C	c.(3253-3255)GAA>CAA	p.E1085Q	NOL8_uc010mqw.2_RNA|NOL8_uc004arw.2_Missense_Mutation_p.E317Q|NOL8_uc011ltw.1_Missense_Mutation_p.E1017Q	NM_017948	NP_060418	Q76FK4	NOL8_HUMAN	nucleolar protein 8	1085					DNA replication|positive regulation of cell growth	nucleolus	nucleotide binding|protein binding|RNA binding			ovary(1)	1						TCTTCCTCTTCTGAACTGCTG	0.388		NA											57	185					0	0	0	0
MURC	347273	broad.mit.edu	37	9	103340680	103340680	+	Silent	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr9:103340680C>T	uc004bba.2	+	1	345	c.255C>T	c.(253-255)ATC>ATT	p.I85I		NM_001018116	NP_001018126	Q5BKX8	MURC_HUMAN	muscle-related coiled-coil protein	85					cell differentiation|muscle organ development|transcription, DNA-dependent					ovary(1)	1		Acute lymphoblastic leukemia(62;0.0461)				CAGGGCATATCATTAACAAAT	0.388		NA											25	67					0	0	0	0
ACTL7B	10880	broad.mit.edu	37	9	111617356	111617356	+	Silent	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr9:111617356G>A	uc004bdi.2	-	1	920	c.855C>T	c.(853-855)GAC>GAT	p.D285D		NM_006686	NP_006677	Q9Y614	ACL7B_HUMAN	actin-like 7B	285						actin cytoskeleton|cytoplasm	structural constituent of cytoskeleton			pancreas(1)	1						TGAGTTTGCCGTCCGGGAGCT	0.642		NA											78	30					0	0	0	0
OR2K2	26248	broad.mit.edu	37	9	114090514	114090514	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr9:114090514G>C	uc011lwp.1	-	1	200	c.200C>G	c.(199-201)TCT>TGT	p.S67C		NM_205859	NP_995581	Q8NGT1	OR2K2_HUMAN	olfactory receptor, family 2, subfamily K,	96	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						ATCCATGAAAGAGAGATTTCC	0.418		NA											25	44					0	0	0	0
ALAD	210	broad.mit.edu	37	9	116152945	116152945	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr9:116152945C>T	uc011lxf.1	-	6	611	c.409G>A	c.(409-411)GAA>AAA	p.E137K	ALAD_uc011lxe.1_Missense_Mutation_p.E120K|ALAD_uc004bhl.3_Missense_Mutation_p.E166K	NM_000031	NP_000022	P13716	HEM2_HUMAN	delta-aminolevulinic acid dehydratase	137					heme biosynthetic process|protein homooligomerization	cytosol	identical protein binding|lead ion binding|porphobilinogen synthase activity|zinc ion binding				0					Aminolevulinic acid(DB00855)	GCTCCGTTTTCACTCAGGAGC	0.622		NA											9	19					0	0	0	0
ZNF618	114991	broad.mit.edu	37	9	116794974	116794974	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr9:116794974T>G	uc004bid.2	+	12	1233	c.1134T>G	c.(1132-1134)TTT>TTG	p.F378L	ZNF618_uc004bic.2_Missense_Mutation_p.F285L|ZNF618_uc011lxi.1_Missense_Mutation_p.F345L|ZNF618_uc011lxj.1_Missense_Mutation_p.F346L|ZNF618_uc010mvb.2_5'UTR	NM_133374	NP_588615	Q5T7W0	ZN618_HUMAN	zinc finger protein 618	378					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AAAACCACTTTGAAGAGACGA	0.562		NA											39	71					0	0	0	0
PBX3	5090	broad.mit.edu	37	9	128678148	128678148	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr9:128678148G>A	uc004bqb.2	+	3	574	c.458G>A	c.(457-459)AGA>AAA	p.R153K	PBX3_uc004bqc.2_Intron|PBX3_uc004bqd.2_Intron|PBX3_uc011lzw.1_Missense_Mutation_p.R78K|PBX3_uc011lzx.1_Missense_Mutation_p.R64K|PBX3_uc004bqe.2_Missense_Mutation_p.R40K	NM_006195	NP_006186	P40426	PBX3_HUMAN	pre-B-cell leukemia homeobox 3 isoform 1	153					anterior compartment pattern formation|posterior compartment specification		sequence-specific DNA binding transcription factor activity			upper_aerodigestive_tract(1)	1						TCAGATTACAGAGCCAAATTG	0.507		NA											31	99					0	0	0	0
GARNL3	84253	broad.mit.edu	37	9	130119513	130119513	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr9:130119513G>C	uc011mae.1	+	21	2352	c.1951G>C	c.(1951-1953)GAC>CAC	p.D651H	GARNL3_uc011mad.1_Missense_Mutation_p.D629H|GARNL3_uc010mxi.2_5'UTR	NM_032293	NP_115669	Q5VVW2	GARL3_HUMAN	GTPase activating Rap/RanGAP domain-like 3	651	CNH.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity|small GTPase regulator activity			ovary(1)|central_nervous_system(1)|skin(1)	3						CTGTCTGTCTGACTCTCCCAT	0.522		NA											43	45					0	0	0	0
GARNL3	84253	broad.mit.edu	37	9	130119609	130119609	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr9:130119609G>C	uc011mae.1	+	21	2448	c.2047G>C	c.(2047-2049)GAG>CAG	p.E683Q	GARNL3_uc011mad.1_Missense_Mutation_p.E661Q|GARNL3_uc010mxi.2_5'UTR	NM_032293	NP_115669	Q5VVW2	GARL3_HUMAN	GTPase activating Rap/RanGAP domain-like 3	683	CNH.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity|small GTPase regulator activity			ovary(1)|central_nervous_system(1)|skin(1)	3						TGTGGTGAATGAGAGCACAGG	0.507		NA											23	27					0	0	0	0
NUP214	8021	broad.mit.edu	37	9	134073419	134073419	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr9:134073419C>T	uc004cag.2	+	29	4649	c.4538C>T	c.(4537-4539)TCA>TTA	p.S1513L	NUP214_uc004cah.2_Missense_Mutation_p.S1503L|NUP214_uc004cai.2_Missense_Mutation_p.S943L|NUP214_uc010mzg.2_RNA|NUP214_uc011mcg.1_Missense_Mutation_p.S339L|NUP214_uc011mcf.1_Missense_Mutation_p.S290L|NUP214_uc010mzh.1_Missense_Mutation_p.S27L|NUP214_uc010mzi.1_Missense_Mutation_p.S27L	NM_005085	NP_005076	P35658	NU214_HUMAN	nucleoporin 214kDa	1513	Pro/Ser/Thr-rich.|11 X 3 AA approximate repeats.|11 X 5 AA approximate repeats.|18 X 4 AA approximate repeats.				carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			breast(7)|lung(3)|skin(3)|ovary(2)|central_nervous_system(1)	16	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		GTCTCAGCATCAGCAGCCTCA	0.552		NA	T	DEK|SET|ABL1	AML|T-ALL								15	102					0	0	0	0
NOTCH1	4851	broad.mit.edu	37	9	139401080	139401080	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr9:139401080C>T	uc004chz.2	-	24	3913	c.3913G>A	c.(3913-3915)GAG>AAG	p.E1305K	NOTCH1_uc004cia.1_Missense_Mutation_p.E535K	NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	1305	Extracellular (Potential).|EGF-like 33.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		ATGACGGACTCGCAGCGGCGC	0.692		NA	T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			9	11					0	0	0	0
ASMTL	8623	broad.mit.edu	37	X	1546872	1546872	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chrX:1546872C>G	uc004cpx.1	-	7	763	c.652G>C	c.(652-654)GAG>CAG	p.E218Q	ASMTL_uc011mhe.1_Missense_Mutation_p.E142Q|ASMTL_uc004cpy.1_Missense_Mutation_p.E202Q|ASMTL_uc011mhf.1_Missense_Mutation_p.E160Q	NM_004192	NP_004183	O95671	ASML_HUMAN	acetylserotonin O-methyltransferase-like	218	MAF-like.				melatonin biosynthetic process	cytoplasm	acetylserotonin O-methyltransferase activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CGCAGGTCCTCCGGACGGGGC	0.647		NA											16	40					0	0	0	0
NHS	4810	broad.mit.edu	37	X	17745088	17745088	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chrX:17745088G>C	uc004cxx.2	+	6	3137	c.2799G>C	c.(2797-2799)TTG>TTC	p.L933F	NHS_uc011mix.1_Missense_Mutation_p.L954F|NHS_uc004cxy.2_Missense_Mutation_p.L777F|NHS_uc004cxz.2_Missense_Mutation_p.L756F|NHS_uc004cya.2_Missense_Mutation_p.L656F	NM_198270	NP_938011	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome protein isoform 1	933						nucleus				skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	Hepatocellular(33;0.183)					TAAATGACTTGAAAACAAATG	0.423		NA											82	19					0	0	0	0
SCML1	6322	broad.mit.edu	37	X	17762333	17762333	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chrX:17762333C>G	uc004cyb.2	+	2	352	c.27C>G	c.(25-27)ATC>ATG	p.I9M	SCML1_uc004cyc.2_Missense_Mutation_p.I9M|SCML1_uc004cyd.2_Intron|SCML1_uc004cye.2_Intron	NM_001037540	NP_001032629	Q9UN30	SCML1_HUMAN	sex comb on midleg-like 1 isoform a	9					anatomical structure morphogenesis	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|ovary(1)	3	Hepatocellular(33;0.183)					CCAGTGAAATCGATGTGGTTT	0.328		NA											19	29					0	0	0	0
SCML1	6322	broad.mit.edu	37	X	17768106	17768106	+	Silent	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chrX:17768106C>G	uc004cyb.2	+	6	721	c.396C>G	c.(394-396)TCC>TCG	p.S132S	SCML1_uc004cyc.2_Silent_p.S105S|SCML1_uc004cyd.2_Silent_p.S11S|SCML1_uc004cye.2_Silent_p.S11S	NM_001037540	NP_001032629	Q9UN30	SCML1_HUMAN	sex comb on midleg-like 1 isoform a	132					anatomical structure morphogenesis	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|ovary(1)	3	Hepatocellular(33;0.183)					AGACATTCTCCTACCCTGAAA	0.418		NA											32	56					0	0	0	0
MAGEB16	139604	broad.mit.edu	37	X	35820840	35820841	+	Missense_Mutation	DNP	CC	CC	GA			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chrX:35820840_35820841CC>GA	uc010ngt.1	+	2	806_807	c.527_528CC>GA	c.(526-528)ACC>AGA	p.T176R		NM_001099921	NP_001093391	A2A368	MAGBG_HUMAN	melanoma antigen family B, 16	176	MAGE.									lung(3)|ovary(2)|breast(1)|skin(1)	7						GTGGACCCCACCACCCATTGCT	0.51		NA											8	17					0	0	0	0
ATRX	546	broad.mit.edu	37	X	76776376	76776376	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chrX:76776376G>A	uc004ecp.3	-	34	7322	c.7090C>T	c.(7090-7092)CTC>TTC	p.L2364F	ATRX_uc004ecq.3_Missense_Mutation_p.L2326F|ATRX_uc004eco.3_Missense_Mutation_p.L2149F	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	2364					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	GCCTCTGAGAGATTCATGTTC	0.348		NA	Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						21	12					0	0	0	0
LPAR4	2846	broad.mit.edu	37	X	78010388	78010388	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chrX:78010388G>A	uc010nme.2	+	2	427	c.22G>A	c.(22-24)GAC>AAC	p.D8N		NM_005296	NP_005287	Q99677	LPAR4_HUMAN	lysophosphatidic acid receptor 4	8	Extracellular (Potential).					integral to plasma membrane	lipid binding|purinergic nucleotide receptor activity, G-protein coupled			ovary(3)	3						AAGATTCATTGACTTCCAATT	0.438		NA											14	23					0	0	0	0
DRP2	1821	broad.mit.edu	37	X	100496666	100496666	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chrX:100496666C>T	uc004egz.2	+	7	938	c.569C>T	c.(568-570)CCG>CTG	p.P190L	DRP2_uc011mrh.1_Missense_Mutation_p.P112L	NM_001939	NP_001930	Q13474	DRP2_HUMAN	dystrophin related protein 2	190					central nervous system development	cytoplasm|cytoskeleton	zinc ion binding			ovary(2)	2						GATACCTCCCCGAAACAGCGG	0.527		NA											10	39					0	0	0	0
NRK	203447	broad.mit.edu	37	X	105179293	105179293	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chrX:105179293G>T	uc004emd.2	+	21	3934	c.3631G>T	c.(3631-3633)GAG>TAG	p.E1211*	NRK_uc010npc.1_Nonsense_Mutation_p.E879*	NM_198465	NP_940867	Q7Z2Y5	NRK_HUMAN	Nik related kinase	1211	CNH.						ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(7)|ovary(3)|lung(2)|large_intestine(1)|central_nervous_system(1)	14						GTTCACTTCTGAGATCTGCTG	0.353		NA								HNSCC(51;0.14)			20	11					5.04e-11	5.39e-11	1	0
LUZP4	51213	broad.mit.edu	37	X	114540829	114540829	+	Silent	SNP	G	G	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chrX:114540829G>A	uc004eqa.2	+	4	436	c.402G>A	c.(400-402)GGG>GGA	p.G134G	LUZP4_uc004eqb.2_Silent_p.G52G	NM_016383	NP_057467	Q9P127	LUZP4_HUMAN	leucine zipper protein 4	134						nucleus				ovary(2)	2						AGTCAGAGGGGAACCAGCATC	0.433		NA											18	24					0	0	0	0
GLUD2	2747	broad.mit.edu	37	X	120183061	120183061	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chrX:120183061C>G	uc004eto.2	+	1	1600	c.1523C>G	c.(1522-1524)TCT>TGT	p.S508C		NM_012084	NP_036216	P49448	DHE4_HUMAN	glutamate dehydrogenase 2 precursor	508					glutamate biosynthetic process|glutamate catabolic process	mitochondrial matrix	ADP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|leucine binding			pancreas(1)	1					L-Glutamic Acid(DB00142)|NADH(DB00157)	ATTGTGCACTCTGCCTTGGCA	0.463		NA											31	24					0	0	0	0
GPR112	139378	broad.mit.edu	37	X	135427079	135427079	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chrX:135427079C>G	uc004ezu.1	+	6	1505	c.1214C>G	c.(1213-1215)TCA>TGA	p.S405*	GPR112_uc010nsb.1_Nonsense_Mutation_p.S200*|GPR112_uc010nsc.1_Nonsense_Mutation_p.S172*	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	405	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					TCTTTATTTTCAACTATTGAG	0.388		NA											25	49					0	0	0	0
CXorf40A	91966	broad.mit.edu	37	X	148628500	148628500	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chrX:148628500G>C	uc004fdb.2	+	5	741	c.469G>C	c.(469-471)GAA>CAA	p.E157Q	CXorf40A_uc011mxm.1_Missense_Mutation_p.E157Q|CXorf40A_uc011mxn.1_Missense_Mutation_p.E157Q|CXorf40A_uc004fdd.2_Missense_Mutation_p.E157Q|CXorf40A_uc004fde.1_Intron|CXorf40A_uc004fdg.2_Missense_Mutation_p.E157Q|CXorf40A_uc004fdf.2_Missense_Mutation_p.E157Q|CXorf40A_uc004fdh.2_Intron|CXorf40A_uc010nsy.2_Missense_Mutation_p.E157Q|CXorf40A_uc004fdi.2_Missense_Mutation_p.E174Q	NM_178124	NP_835225	Q8TE69	CX04A_HUMAN	chromosome X open reading frame 40	157							protein binding				0	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)					ATTGGGGCATGAAGTGTGACA	0.478		NA											4	11					0	0	0	0
CXorf40B	541578	broad.mit.edu	37	X	149100770	149100770	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chrX:149100770C>G	uc004fdy.2	-	5	985	c.469G>C	c.(469-471)GAA>CAA	p.E157Q	CXorf40B_uc011mxs.1_Intron	NM_001013845	NP_001013867	Q96DE9	CX04B_HUMAN	hypothetical protein LOC541578	157											0	Acute lymphoblastic leukemia(192;6.56e-05)					TGTCACACTTCATGCCCCAAA	0.483		NA											13	84					0	0	0	0
PLXNB3	5365	broad.mit.edu	37	X	153035337	153035337	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chrX:153035337C>G	uc004fii.2	+	7	1746	c.1572C>G	c.(1570-1572)CAC>CAG	p.H524Q	PLXNB3_uc011mzb.1_Missense_Mutation_p.H60Q|PLXNB3_uc011mzc.1_Missense_Mutation_p.H206Q|PLXNB3_uc010nuk.2_Missense_Mutation_p.H547Q|PLXNB3_uc011mzd.1_Missense_Mutation_p.H163Q	NM_005393	NP_005384	Q9ULL4	PLXB3_HUMAN	plexin B3 isoform 1	524	Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	protein binding|receptor activity			lung(1)	1	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					AGGACAGCCACTGCCTGCACA	0.687		NA											4	7					0	0	0	0
CYP2J2	1573	broad.mit.edu	37	1	60381745	60381746	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr1:60381745_60381746insA	uc001czq.2	-	2	242_243	c.237_238insT	c.(235-240)TTTAGCfs	p.F79fs		NM_000775	NP_000766	P51589	CP2J2_HUMAN	cytochrome P450, family 2, subfamily J,	79_80					epoxygenase P450 pathway|linoleic acid metabolic process|regulation of heart contraction|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	arachidonic acid 11,12-epoxygenase activity|arachidonic acid 14,15-epoxygenase activity|aromatase activity|electron carrier activity|heme binding|linoleic acid epoxygenase activity			ovary(1)	1	all_cancers(7;0.000396)					AGCTCCAAGCTAAAAAGGTTCC	0.411		NA											21	65	---	---	---	---	NA	NA	NA	NA
CASP5	838	broad.mit.edu	37	11	104879687	104879687	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr11:104879687delT	uc010rva.1	-	2	60	c.28delA	c.(28-30)AGGfs	p.R10fs	CASP5_uc010ruz.1_Frame_Shift_Del_p.R23fs|CASP5_uc010rvb.1_Intron|CASP5_uc010rvc.1_Intron|CASP5_uc009yxh.2_Intron|CASP5_uc010rvd.1_Intron	NM_004347	NP_004338	P51878	CASP5_HUMAN	caspase 5 isoform a precursor	10					apoptosis|cellular response to mechanical stimulus|proteolysis|regulation of apoptosis	intracellular	cysteine-type endopeptidase activity|protein binding			ovary(2)|lung(1)	3		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000943)|Epithelial(105;0.0104)|all cancers(92;0.042)		TTCTTACGCCTTTTTTTTTTG	0.388		NA											8	59	---	---	---	---	NA	NA	NA	NA
MLL2	8085	broad.mit.edu	37	12	49436553	49436559	+	Frame_Shift_Del	DEL	CGGCTGC	CGGCTGC	-			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr12:49436553_49436559delCGGCTGC	uc001rta.3	-	26	5747_5753	c.5747_5753delGCAGCCG	c.(5746-5754)GGCAGCCGTfs	p.G1916fs		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	1916_1918					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						CAGTGGCGTACGGCTGCCTTCTAGGCC	0.546		NA	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			22	86	---	---	---	---	NA	NA	NA	NA
OR6C74	254783	broad.mit.edu	37	12	55641287	55641287	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr12:55641287delA	uc010spg.1	+	1	216	c.216delA	c.(214-216)ACAfs	p.T72fs		NM_001005490	NP_001005490	A6NCV1	O6C74_HUMAN	olfactory receptor, family 6, subfamily C,	72	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						TCTCATTCACAACTGTCTACA	0.393		NA											61	189	---	---	---	---	NA	NA	NA	NA
PDCD7	10081	broad.mit.edu	37	15	65426079	65426079	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr15:65426079delG	uc002aol.2	-	1	96	c.41delC	c.(40-42)CCAfs	p.P14fs		NM_005707	NP_005698	Q8N8D1	PDCD7_HUMAN	programmed cell death 7	14	Pro-rich.				apoptosis|induction of apoptosis|response to glucocorticoid stimulus	U12-type spliceosomal complex					0						CGGGGGCGGTGGGCCTGGGCG	0.692		NA											2	4	---	---	---	---	NA	NA	NA	NA
TP53	7157	broad.mit.edu	37	17	7578234	7578235	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr17:7578234_7578235insT	uc002gim.2	-	6	808_809	c.614_615insA	c.(613-615)TATfs	p.Y205fs	TP53_uc002gig.1_Frame_Shift_Ins_p.Y205fs|TP53_uc002gih.2_Frame_Shift_Ins_p.Y205fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Frame_Shift_Ins_p.Y73fs|TP53_uc010cng.1_Frame_Shift_Ins_p.Y73fs|TP53_uc002gii.1_Frame_Shift_Ins_p.Y73fs|TP53_uc010cnh.1_Frame_Shift_Ins_p.Y205fs|TP53_uc010cni.1_Frame_Shift_Ins_p.Y205fs|TP53_uc002gij.2_Frame_Shift_Ins_p.Y205fs|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Frame_Shift_Ins_p.Y112fs|TP53_uc002gio.2_Frame_Shift_Ins_p.Y73fs|TP53_uc010vug.1_Frame_Shift_Ins_p.Y166fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	205	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Y -> N (in sporadic cancers; somatic mutation).|Y -> D (in sporadic cancers; somatic mutation).|Y -> F (in sporadic cancers; somatic mutation).|Y -> S (in sporadic cancers; somatic mutation).|Y -> H (in sporadic cancers; somatic mutation).|Y -> C (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Y205C(55)|p.Y205D(13)|p.Y205S(11)|p.Y205F(8)|p.0?(7)|p.Y205H(5)|p.Y205*(4)|p.Y205N(2)|p.K164_P219del(1)|p.Y205fs*43(1)|p.Y205fs*42(1)|p.Y112C(1)|p.E204fs*39(1)|p.Y73C(1)|p.E204_N210delEYLDDRN(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGTCATCCAAATACTCCACACG	0.54		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			19	21	---	---	---	---	NA	NA	NA	NA
SPAG4	6676	broad.mit.edu	37	20	34207645	34207646	+	Frame_Shift_Ins	INS	-	-	C	rs76103999		TCGA-CN-6011-01A-11D-1683-08	TCGA-CN-6011-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0e0aa5da-2cb2-47b8-b000-83a07d68ed29	090dd4aa-5adb-4e8e-9ea0-d25775dfa21c	g.chr20:34207645_34207646insC	uc002xdb.1	+	10	1171_1172	c.1054_1055insC	c.(1054-1056)GCCfs	p.A352fs	SPAG4_uc010zvi.1_Frame_Shift_Ins_p.A275fs	NM_003116	NP_003107	Q9NPE6	SPAG4_HUMAN	sperm associated antigen 4	352	SUN.				spermatogenesis	cilium|flagellar axoneme|integral to membrane	structural molecule activity				0	Lung NSC(9;0.0053)|all_lung(11;0.00785)		BRCA - Breast invasive adenocarcinoma(18;0.0127)			AGCCAACAGCGCCCCCCGCGAT	0.619		NA											12	61	---	---	---	---	NA	NA	NA	NA