Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
HDAC8	55869	broad.mit.edu	37	X	71792627	71792627	+	Translation_Start_Site	SNP	G	G	A			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chrX:71792627G>A	ENST00000439122.2	-	0	271				HDAC8_ENST00000373589.4_De_novo_Start_OutOfFrame|HDAC8_ENST00000373556.3_De_novo_Start_OutOfFrame|HDAC8_ENST00000373571.1_De_novo_Start_OutOfFrame|HDAC8_ENST00000373560.2_De_novo_Start_OutOfFrame|HDAC8_ENST00000429103.2_De_novo_Start_OutOfFrame|HDAC8_ENST00000373561.4_De_novo_Start_OutOfFrame|HDAC8_ENST00000373583.1_De_novo_Start_OutOfFrame|HDAC8_ENST00000373559.4_De_novo_Start_OutOfFrame|HDAC8_ENST00000373573.3_De_novo_Start_OutOfFrame|HDAC8_ENST00000373554.1_De_novo_Start_OutOfFrame|HDAC8_ENST00000478743.1_5'UTR	NM_001166419.1	NP_001159891.1	Q9BY41	HDAC8_HUMAN	histone deacetylase 8						chromatin assembly or disassembly|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|nuclear chromosome	histone deacetylase activity (H3-K16 specific)|metal ion binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|transcription factor binding			breast(3)|cervix(1)|endometrium(1)|lung(4)|prostate(1)	10	Renal(35;0.156)				Vorinostat(DB02546)	GCTTAAAACCGTTCCGCAGCC	0.577000													9	22					0	0	1	0	0
KIAA1045	23349	broad.mit.edu	37	9	34976210	34976210	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr9:34976210G>A	ENST00000242315.3	+	4	708	c.626G>A	c.(625-627)cGg>cAg	p.R209Q	KIAA1045_ENST00000544237.1_Missense_Mutation_p.R209Q|KIAA1045_ENST00000476115.2_3'UTR	NM_015297.1	NP_056112.1	Q9UPV7	K1045_HUMAN	KIAA1045	209							calcium ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19			LUSC - Lung squamous cell carcinoma(32;0.00575)			ACCTTTCAGCGGTGTAAAGTC	0.507000													14	34					0	0	1	0	0
NBPF1	55672	broad.mit.edu	37	1	16918653	16918653	+	Splice_Site	SNP	C	C	T			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr1:16918653C>T	ENST00000430580.2	-	6	853		c.e6+1			NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1							cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TCTTAACTTACTGTTGTGAAA	0.418000													5	87					0	0	1	0	0
LRFN5	145581	broad.mit.edu	37	14	42356613	42356613	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr14:42356613C>A	ENST00000554171.1	+	5	3217	c.785C>A	c.(784-786)aCc>aAc	p.T262N	LRFN5_ENST00000554120.1_Missense_Mutation_p.T262N|LRFN5_ENST00000298119.4_Missense_Mutation_p.T262N			Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III domain containing 5	262	LRRCT.					integral to membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(67)|ovary(5)|pancreas(3)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(2)	120			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		GACTTAGAGACCTGTGCTTCT	0.443000										HNSCC(30;0.082)			45	90					1.30916e-28	1.42975e-28	1	1	0
ACRC	93953	broad.mit.edu	37	X	70823742	70823742	+	Silent	SNP	C	C	T			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chrX:70823742C>T	ENST00000373695.1	+	7	1152	c.615C>T	c.(613-615)tcC>tcT	p.S205S	ACRC_ENST00000373696.3_Silent_p.S205S			Q96QF7	ACRC_HUMAN	acidic repeat containing	205	Asp/Ser-rich.					nucleus		p.S205S(1)		autonomic_ganglia(1)|breast(1)|endometrium(15)|kidney(4)|large_intestine(4)|lung(20)|ovary(5)|prostate(1)|skin(2)|stomach(1)	54	Renal(35;0.156)					ATGATTCATCCGACGACAACA	0.498000													188	256					0	0	1	0	0
KIAA1551	55196	broad.mit.edu	37	12	32137594	32137594	+	Silent	SNP	A	A	G			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr12:32137594A>G	ENST00000312561.4	+	4	4119	c.3705A>G	c.(3703-3705)gtA>gtG	p.V1235V	KIAA1551_ENST00000535596.1_Intron	NM_018169.3	NP_060639			KIAA1551																		AGAGCCTTGTAAATAATCCAA	0.368000													17	34					0	0	1	0	0
ZNF733P	643955	broad.mit.edu	37	7	62752443	62752443	+	RNA	SNP	G	G	C			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr7:62752443G>C	ENST00000331425.6	-	0	992					NR_003952.1																						CTTATGTCTAGTAAGGTTTGA	0.438000													4	44					0	0	1	0	0
BIRC6	57448	broad.mit.edu	37	2	32730212	32730212	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr2:32730212C>T	ENST00000421745.2	+	50	9774	c.9640C>T	c.(9640-9642)Ctt>Ttt	p.L3214F		NM_016252.3	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	3214					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					TACCATTCACCTTCCTGCAGC	0.468000													3	6					0	0	1	0	0
NKRF	55922	broad.mit.edu	37	X	118725222	118725222	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chrX:118725222G>A	ENST00000371527.1	-	2	818	c.166C>T	c.(166-168)Cgt>Tgt	p.R56C	NKRF_ENST00000304449.5_Missense_Mutation_p.R56C|NKRF_ENST00000487600.1_5'UTR|NKRF_ENST00000542113.1_Missense_Mutation_p.R71C	NM_001173488.1	NP_001166959.1	O15226	NKRF_HUMAN	NFKB repressing factor	56	Active repression domain.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|double-stranded RNA binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(2)|lung(9)|ovary(1)|prostate(3)|skin(1)|urinary_tract(1)	30						GGCTCAAAACGAGGTCTCGCA	0.353000													30	73					0	0	1	0	0
PDXDC2P	283970	broad.mit.edu	37	16	70065826	70065826	+	RNA	SNP	T	T	C	rs3169319	by1000genomes	TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr16:70065826T>C	ENST00000531894.1	-	0	796					NR_003610.1													p.M209V(4)									GATCCAAACATAGTGTTACAG	0.453000													3	62					0	0	1	0	0
HRAS	3265	broad.mit.edu	37	11	533552	533552	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr11:533552C>G	ENST00000417302.1	-	4	538	c.351G>C	c.(349-351)aaG>aaC	p.K117N	HRAS_ENST00000451590.1_Missense_Mutation_p.K117N|HRAS_ENST00000311189.7_Missense_Mutation_p.K117N|HRAS_ENST00000397596.2_Missense_Mutation_p.K117N|HRAS_ENST00000397594.1_Missense_Mutation_p.K117N	NM_176795.3	NP_789765.1	P01112	RASH_HUMAN	Harvey rat sarcoma viral oncogene homolog	117			K -> R (in FCSS).		activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.K117N(3)		adrenal_gland(1)|bone(3)|breast(7)|cervix(23)|endometrium(4)|haematopoietic_and_lymphoid_tissue(12)|kidney(1)|large_intestine(2)|liver(1)|lung(16)|oesophagus(2)|penis(2)|pituitary(10)|prostate(31)|salivary_gland(24)|skin(184)|soft_tissue(38)|stomach(14)|testis(5)|thymus(1)|thyroid(173)|upper_aerodigestive_tract(122)|urinary_tract(225)	901		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	CCAGGTCACACTTGTTCCCCA	0.632000		6	Mis		"""infrequent sarcomas, rare other types"""	"""rhadomyosarcoma, ganglioneuroblastoma, bladder"""			Costello syndrome	HNSCC(11;0.0054)			29	55					0	0	1	0	0
TET1	80312	broad.mit.edu	37	10	70446399	70446399	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr10:70446399G>A	ENST00000373644.4	+	11	5548	c.5339G>A	c.(5338-5340)cGa>cAa	p.R1780Q		NM_030625.2	NP_085128.2	Q8NFU7	TET1_HUMAN	tet methylcytosine dioxygenase 1	1780					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(2)|ovary(5)|prostate(1)|upper_aerodigestive_tract(2)	21						CCTATTCCCCGAATCAAGCGG	0.473000													9	49					0	0	1	0	0
TFIP11	24144	broad.mit.edu	37	22	26902780	26902780	+	Silent	SNP	G	G	A			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr22:26902780G>A	ENST00000407690.1	-	5	607	c.324C>T	c.(322-324)gaC>gaT	p.D108D	TFIP11_ENST00000405938.1_Silent_p.D108D|TFIP11_ENST00000407431.1_Silent_p.D108D|TFIP11_ENST00000407148.1_Silent_p.D108D	NM_012143.2	NP_036275.1	Q9UBB9	TFP11_HUMAN	tuftelin interacting protein 11	108					biomineral tissue development	catalytic step 2 spliceosome|cytoplasm|nuclear speck	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(5)|liver(1)|lung(7)|prostate(2)|skin(1)|urinary_tract(1)	25						TAGGAAAGTCGTCCTGCTTAA	0.493000													10	69					0	0	1	0	0
ACSM2B	348158	broad.mit.edu	37	16	20576155	20576155	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr16:20576155G>A	ENST00000329697.6	-	2	181	c.13C>T	c.(13-15)Cga>Tga	p.R5*	ACSM2B_ENST00000565322.1_Intron|ACSM2B_ENST00000414188.2_Nonsense_Mutation_p.R5*|ACSM2B_ENST00000565232.1_Nonsense_Mutation_p.R5*|ACSM2B_ENST00000567001.1_Nonsense_Mutation_p.R5*	NM_001105069.1	NP_001098539.1	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member 2B	5					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding	p.R5*(1)		breast(4)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(4)|lung(33)|ovary(1)|prostate(1)|skin(5)	57						TGAACTTTTCGCAGCCAATGC	0.493000													19	26					0	0	1	0	0
RHOA	387	broad.mit.edu	37	3	49412941	49412941	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr3:49412941C>T	ENST00000418115.1	-	2	466	c.82G>A	c.(82-84)Gac>Aac	p.D28N	RHOA_ENST00000422781.1_Missense_Mutation_p.D28N|RHOA_ENST00000454011.2_Missense_Mutation_p.D28N	NM_001664.2	NP_001655.1	P61586	RHOA_HUMAN	ras homolog family member A	28					axon guidance|interspecies interaction between organisms|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of axonogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of neuron differentiation|positive regulation of NF-kappaB import into nucleus|positive regulation of stress fiber assembly|regulation of cell migration|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|spindle assembly involved in mitosis	cytoskeleton|cytosol|plasma membrane	GTP binding|GTPase activity|myosin binding			cervix(1)|kidney(1)|large_intestine(5)|lung(1)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	12				BRCA - Breast invasive adenocarcinoma(193;8.58e-05)|Kidney(197;0.0023)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)	Atorvastatin(DB01076)|Simvastatin(DB00641)	GGGAACTGGTCCTTGCTGAAG	0.463000													42	54					0	0	1	0	0
AAR2	25980	broad.mit.edu	37	20	34843607	34843607	+	Silent	SNP	G	G	A			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr20:34843607G>A	ENST00000373932.3	+	4	1441	c.1095G>A	c.(1093-1095)gcG>gcA	p.A365A	AAR2_ENST00000320849.4_Silent_p.A365A|AAR2_ENST00000397286.3_Intron	NM_015511.3	NP_056326.2			AAR2 splicing factor homolog (S. cerevisiae)																		ACTTTGCTGCGGAACCTGAGG	0.602000													23	78					0	0	1	0	0
C1S	716	broad.mit.edu	37	12	7177887	7177887	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr12:7177887C>T	ENST00000406697.1	+	15	2627	c.1999C>T	c.(1999-2001)Cgg>Tgg	p.R667W	C1S_ENST00000402681.3_Missense_Mutation_p.R500W|C1S_ENST00000328916.3_Missense_Mutation_p.R667W|C1S_ENST00000360817.5_Missense_Mutation_p.R667W			P09871	C1S_HUMAN	complement component 1, s subcomponent	667	Peptidase S1.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(8)|liver(4)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	33					Abciximab(DB00054)|Adalimumab(DB00051)|Basiliximab(DB00074)|Cetuximab(DB00002)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Rituximab(DB00073)|Trastuzumab(DB00072)	GCTCTACACACGGGTAAAGAA	0.532000													8	134					0	0	1	0	0
ZNF292	23036	broad.mit.edu	37	6	87965501	87965501	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr6:87965501G>C	ENST00000369577.3	+	8	2197	c.2154G>C	c.(2152-2154)caG>caC	p.Q718H	ZNF292_ENST00000339907.4_Missense_Mutation_p.Q713H	NM_015021.1	NP_055836.1	O60281	ZN292_HUMAN	zinc finger protein 292	718					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(27)|lung(21)|ovary(4)|prostate(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	89		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		TTGAAATGCAGAGCAAAAAAG	0.363000													11	30					0	0	1	0	0
PRRC2C	23215	broad.mit.edu	37	1	171509628	171509628	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr1:171509628A>C	ENST00000367742.3	+	16	3265	c.3023A>C	c.(3022-3024)aAt>aCt	p.N1008T	PRRC2C_ENST00000426496.2_Missense_Mutation_p.N1006T|PRRC2C_ENST00000392078.3_Missense_Mutation_p.N1008T|PRRC2C_ENST00000338920.4_Missense_Mutation_p.N1006T			Q9Y520	PRC2C_HUMAN	proline-rich coiled-coil 2C	1006							protein C-terminus binding										GAAGAAGTTAATGATAGACCT	0.413000													6	17					0	0	1	0	0
TENM1	10178	broad.mit.edu	37	X	123526165	123526165	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chrX:123526165C>G	ENST00000422452.2	-	28	5488	c.5425G>C	c.(5425-5427)Gat>Cat	p.D1809H	STAG2_ENST00000469481.1_Intron|TENM1_ENST00000371130.3_Missense_Mutation_p.D1802H	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		GTTATATGATCAAAATCTATG	0.423000													30	51					0	0	1	0	0
BMS1P20	96610	broad.mit.edu	37	22	22661208	22661208	+	RNA	SNP	C	C	T			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr22:22661208C>T	ENST00000426066.1	+	0	300					NR_027293.1																						CTGAATCATGCAGAATTTGAA	0.408000													5	42					0	0	1	0	0
PARD3B	117583	broad.mit.edu	37	2	205829980	205829980	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr2:205829980G>A	ENST00000406610.2	+	3	535	c.328G>A	c.(328-330)Gcc>Acc	p.A110T	PARD3B_ENST00000351153.1_Missense_Mutation_p.A110T|PARD3B_ENST00000349953.3_Missense_Mutation_p.A110T|PARD3B_ENST00000358768.2_Missense_Mutation_p.A110T|PARD3B_ENST00000462231.1_Missense_Mutation_p.A110T	NM_057177.6|NM_152526.5|NM_205863.3	NP_476518.4|NP_689739.4|NP_995585.2	Q8TEW8	PAR3L_HUMAN	par-3 family cell polarity regulator beta	110					cell cycle|cell division	endomembrane system|tight junction				breast(1)|endometrium(9)|kidney(2)|large_intestine(6)|liver(4)|lung(33)|ovary(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)	65		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		AGAAGTGGCCGCCCAACTGGC	0.473000													21	21					0	0	1	0	0
SERINC4	619189	broad.mit.edu	37	15	44090131	44090131	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr15:44090131A>C	ENST00000319327.6	-	5	853	c.619T>G	c.(619-621)Tgg>Ggg	p.W207G	SERF2_ENST00000409646.1_Intron|RP11-296A16.1_ENST00000417761.2_Missense_Mutation_p.W86G|SERF2_ENST00000409291.1_Intron|SERINC4_ENST00000249714.3_Silent_p.P33P|HYPK_ENST00000406925.1_5'UTR|SERF2_ENST00000594896.1_Intron|SERINC4_ENST00000299969.6_Missense_Mutation_p.W207G	NM_001258031.1	NP_001244960.1	A6NH21	SERC4_HUMAN	serine incorporator 4	207					phospholipid biosynthetic process	integral to membrane				central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(2)|skin(1)	6		all_cancers(109;3.26e-11)|all_epithelial(112;4.82e-09)|Lung NSC(122;1.61e-06)|all_lung(180;1.5e-05)|Melanoma(134;0.0417)		GBM - Glioblastoma multiforme(94;7.81e-07)		TTCTTGTTCCAGGAATGGGCA	0.493000											OREG0003944	type=REGULATORY REGION|Gene=AK094716|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	12	24					0	0	1	0	0
SLC4A1	6521	broad.mit.edu	37	17	42340064	42340064	+	Silent	SNP	G	G	A	rs55786369		TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr17:42340064G>A	ENST00000262418.6	-	3	201	c.46C>T	c.(46-48)Ctg>Ttg	p.L16L	AC003043.1_ENST00000597382.1_Intron	NM_000342.3	NP_000333.1	P02730	B3AT_HUMAN	solute carrier family 4 (anion exchanger), member 1	16					bicarbonate transport|cellular ion homeostasis	basolateral plasma membrane|cortical cytoskeleton|integral to plasma membrane|Z disc	ankyrin binding|chloride transmembrane transporter activity|inorganic anion exchanger activity|protein anchor|protein homodimerization activity			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(16)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	40		Breast(137;0.014)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.115)		TCCTGCTCCAGATTCTCCTCC	0.587000													7	19					0	0	1	0	0
RBM12B	389677	broad.mit.edu	37	8	94745992	94745992	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr8:94745992G>A	ENST00000399300.2	-	3	2860	c.2647C>T	c.(2647-2649)Cgc>Tgc	p.R883C	RP11-10N23.4_ENST00000517998.1_RNA|RBM12B_ENST00000520961.1_Intron|RBM12B_ENST00000517700.1_Missense_Mutation_p.R763C	NM_203390.2	NP_976324.2	Q8IXT5	RB12B_HUMAN	RNA binding motif protein 12B	883							nucleotide binding|RNA binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(7)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	30	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			ACAAAAGGGCGGTGACTTCTA	0.468000													71	277					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195507876	195507876	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr3:195507876G>C	ENST00000463781.3	-	2	11034	c.10575C>G	c.(10573-10575)gaC>gaG	p.D3525E	MUC4_ENST00000349607.4_Intron|MUC4_ENST00000475231.1_Missense_Mutation_p.D3525E|MUC4_ENST00000346145.4_Intron	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	322					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity	p.D3525E(2)		NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		CTGAGGAAGTGTCGGTGACAG	0.602000													3	4					0	0	1	0	0
IBSP	3381	broad.mit.edu	37	4	88732624	88732624	+	Silent	SNP	C	C	T			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr4:88732624C>T	ENST00000226284.5	+	7	583	c.516C>T	c.(514-516)aaC>aaT	p.N172N		NM_004967.3	NP_004958.2	P21815	SIAL_HUMAN	integrin-binding sialoprotein	172	Asp/Glu-rich (acidic).				biomineral tissue development|cell adhesion|ossification					breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(10)	21		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000333)|COAD - Colon adenocarcinoma(81;0.154)		TGGATGAAAACGAACAAGGCA	0.453000													8	19					0	0	1	0	0
CILP2	148113	broad.mit.edu	37	19	19656757	19656757	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr19:19656757G>A	ENST00000586018.1	+	8	3523	c.3421G>A	c.(3421-3423)Gag>Aag	p.E1141K	CILP2_ENST00000291495.5_Missense_Mutation_p.E1135K			Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	1135						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(17)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	32						GGAGATGAGCGAGGCGGCGCA	0.721000													4	11					0	0	1	0	0
STAG1	10274	broad.mit.edu	37	3	136068032	136068032	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr3:136068032C>T	ENST00000383202.2	-	29	3495	c.3239G>A	c.(3238-3240)gGa>gAa	p.G1080E	STAG1_ENST00000434713.2_Missense_Mutation_p.G820E|STAG1_ENST00000236698.5_Missense_Mutation_p.G1080E|STAG1_ENST00000536929.1_Missense_Mutation_p.G664E	NM_005862.2	NP_005853.2	Q8WVM7	STAG1_HUMAN	stromal antigen 1	1080					cell division|chromosome segregation|mitotic metaphase/anaphase transition|mitotic prometaphase	cell junction|chromatin|chromosome, centromeric region|nucleoplasm	protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(16)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58						TGGAGGTCGTCCTTTCTTATT	0.368000													8	85					0	0	1	0	0
NOXRED1	122945	broad.mit.edu	37	14	77873002	77873002	+	Silent	SNP	A	A	C			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr14:77873002A>C	ENST00000298358.3	-	4	746	c.747T>G	c.(745-747)tcT>tcG	p.S249S	NOXRED1_ENST00000380835.2_Intron			Q6NXP6	CN148_HUMAN	NADP-dependent oxidoreductase domain containing 1	0					proline biosynthetic process		binding|pyrroline-5-carboxylate reductase activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)	9						TGATTTAATAAGATAGCAATG	0.448000													10	18					0	0	1	0	0
RPS6KA3	6197	broad.mit.edu	37	X	20212356	20212356	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chrX:20212356A>G	ENST00000379565.3	-	6	644	c.437T>C	c.(436-438)aTt>aCt	p.I146T	RPS6KA3_ENST00000379548.4_Missense_Mutation_p.I117T|RPS6KA3_ENST00000540702.1_Missense_Mutation_p.I118T|RPS6KA3_ENST00000544447.1_Missense_Mutation_p.I118T	NM_004586.2	NP_004577.1	P51812	KS6A3_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 3	146	Protein kinase 1.				axon guidance|central nervous system development|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|skeletal system development|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein serine/threonine kinase activity			breast(4)|central_nervous_system(4)|endometrium(3)|kidney(2)|large_intestine(5)|liver(14)|lung(7)|ovary(1)|stomach(1)	41						AAAATCCAAAATAAGATACAA	0.303000													25	29					0	0	1	0	0
TGM3	7053	broad.mit.edu	37	20	2293619	2293619	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr20:2293619G>A	ENST00000381458.5	+	5	679	c.616G>A	c.(616-618)Gat>Aat	p.D206N		NM_003245.3	NP_003236.3	Q08188	TGM3_HUMAN	transglutaminase 3	206					cell envelope organization|hair follicle morphogenesis|keratinization|peptide cross-linking|protein tetramerization	cytoplasm|extrinsic to internal side of plasma membrane	acyltransferase activity|calcium ion binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(3)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(11)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	39					L-Glutamine(DB00130)	CGCTGCTACTGATGTGGCCAG	0.463000													18	56					0	0	1	0	0
P2RX7	5027	broad.mit.edu	37	12	121622238	121622238	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr12:121622238C>T	ENST00000328963.5	+	12	1365	c.911C>T	c.(910-912)cCc>cTc	p.P304L	P2RX7_ENST00000541446.1_Missense_Mutation_p.P185L|P2RX7_ENST00000443520.3_3'UTR|P2RX7_ENST00000535250.1_Missense_Mutation_p.P384L|P2RX7_ENST00000546057.1_Missense_Mutation_p.P474L			A8K2Z0	A8K2Z0_HUMAN	purinergic receptor P2X, ligand-gated ion channel, 7	474						integral to membrane	ATP binding|ion channel activity|receptor activity			NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(9)|skin(1)|stomach(1)	19	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					AGGGATAGCCCCGTCTGGTGC	0.617000													14	15					0	0	1	0	0
SEPT9	10801	broad.mit.edu	37	17	75398398	75398398	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr17:75398398A>C	ENST00000329047.8	+	2	1092	c.280A>C	c.(280-282)Att>Ctt	p.I94L	SEPT9_ENST00000427177.1_Missense_Mutation_p.I112L|SEPT9_ENST00000591198.1_Missense_Mutation_p.I93L|SEPT9_ENST00000423034.2_Missense_Mutation_p.I105L|SEPT9_ENST00000590294.1_Missense_Mutation_p.I94L|SEPT9_ENST00000449803.2_5'UTR|SEPT9_ENST00000427674.2_5'UTR|SEPT9_ENST00000588690.1_5'UTR|SEPT9_ENST00000592420.1_5'UTR|SEPT9_ENST00000431235.2_5'UTR	NM_006640.4	NP_006631.2	Q9UHD8	SEPT9_HUMAN	septin 9	112					cell cycle|cell division|protein heterooligomerization	microtubule|perinuclear region of cytoplasm|stress fiber	GTP binding|GTPase activity|protein binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|prostate(2)	16			BRCA - Breast invasive adenocarcinoma(99;0.153)			TGAGCTGTCCATTGACATCTC	0.692000													10	21					0	0	1	0	0
KIAA1244	57221	broad.mit.edu	37	6	138599733	138599733	+	Silent	SNP	G	G	A	rs144684061		TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr6:138599733G>A	ENST00000251691.4	+	13	2440	c.2274G>A	c.(2272-2274)ccG>ccA	p.P758P		NM_020340.4	NP_065073.3	Q5TH69	BIG3_HUMAN	KIAA1244	758	SEC7.				regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(11)|lung(17)|ovary(2)|skin(2)	44	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		GGAAGCGGCCGACCCTGGCGC	0.607000													17	31					0	0	1	0	0
NUP98	4928	broad.mit.edu	37	11	3716824	3716824	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr11:3716824A>C	ENST00000324932.7	-	26	4442	c.4022T>G	c.(4021-4023)cTt>cGt	p.L1341R	NUP98_ENST00000359171.4_Missense_Mutation_p.L1341R|NUP98_ENST00000488828.1_5'UTR|NUP98_ENST00000355260.3_Missense_Mutation_p.L1341R	NM_016320.4|NM_139132.3	NP_057404.2|NP_624358.2	P52948	NUP98_HUMAN	nucleoporin 98kDa	1358					carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(13)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		AAGAAGAGCAAGACGATGATC	0.458000			T	"""HOXA9, NSD1, WHSC1L1, DDX10, TOP1, HOXD13, PMX1, HOXA13, HOXD11, HOXA11, RAP1GDS1, HOXC11"""	AML								28	22					0	0	1	0	0
SART3	9733	broad.mit.edu	37	12	108917236	108917236	+	Nonstop_Mutation	SNP	A	A	G			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr12:108917236A>G	ENST00000228284.3	-	19	3124	c.2890T>C	c.(2890-2892)Tga>Cga	p.*964R	SART3_ENST00000431469.2_Nonstop_Mutation_p.*928R	NM_014706.3	NP_055521.1	Q15020	SART3_HUMAN	squamous cell carcinoma antigen recognized by T cells 3	0					RNA processing	cytoplasm|nuclear speck	nucleotide binding|protein binding|RNA binding			NS(1)|breast(1)|endometrium(8)|kidney(1)|large_intestine(4)|lung(8)|pancreas(1)|stomach(1)	25						CGTCCCGTTCACTTTCTCAGA	0.622000									Porokeratosis				18	50					0	0	1	0	0
POLR3B	55703	broad.mit.edu	37	12	106820975	106820975	+	Splice_Site	SNP	C	C	T			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr12:106820975C>T	ENST00000228347.4	+	13	1324	c.1102C>T	c.(1102-1104)Ctt>Ttt	p.L368F	POLR3B_ENST00000539066.1_Splice_Site_p.L310F|POLR3B_ENST00000549195.1_3'UTR	NM_018082.5	NP_060552.4	Q9NW08	RPC2_HUMAN	polymerase (RNA) III (DNA directed) polypeptide B	368					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding	p.L368F(4)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(14)|lung(22)|ovary(1)|prostate(3)|skin(3)|urinary_tract(2)	57						TTTTTTTTAGCTTTTATCTCT	0.274000													5	18					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179635976	179635976	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr2:179635976A>G	ENST00000589042.1	-	34	8302	c.8078T>C	c.(8077-8079)gTg>gCg	p.V2693A	TTN_ENST00000359218.5_Missense_Mutation_p.V2647A|TTN_ENST00000460472.2_Missense_Mutation_p.V2647A|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000610005.1_RNA|TTN_ENST00000360870.5_Missense_Mutation_p.V2693A|TTN_ENST00000591111.1_Missense_Mutation_p.V2693A|TTN_ENST00000342992.6_Missense_Mutation_p.V2693A|TTN_ENST00000342175.6_Missense_Mutation_p.V2647A	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	2429	Ig-like 15.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGAGGTGGCCACCTTGTAGGT	0.388000													21	31					0	0	1	0	0
C6orf118	168090	broad.mit.edu	37	6	165703480	165703480	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr6:165703480T>C	ENST00000230301.8	-	7	1217	c.1197A>G	c.(1195-1197)atA>atG	p.I399M	C6orf118_ENST00000543069.1_3'UTR|C6orf118_ENST00000494696.2_5'UTR	NM_144980.3	NP_659417.2	Q5T5N4	CF118_HUMAN	chromosome 6 open reading frame 118	399										breast(1)|kidney(2)|large_intestine(9)|liver(1)|lung(21)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	40		Breast(66;6.27e-05)|Ovarian(120;0.0228)|Prostate(117;0.0906)|all_neural(5;0.157)		OV - Ovarian serous cystadenocarcinoma(33;3.23e-18)|BRCA - Breast invasive adenocarcinoma(81;3.11e-06)|GBM - Glioblastoma multiforme(31;0.000313)		ACTTACTGAGTATTTCACACC	0.318000													25	80					0	0	1	0	0
ASXL2	55252	broad.mit.edu	37	2	25967164	25967164	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr2:25967164G>A	ENST00000435504.4	-	13	2335	c.2042C>T	c.(2041-2043)gCt>gTt	p.A681V	ASXL2_ENST00000272341.4_Missense_Mutation_p.A421V|ASXL2_ENST00000404843.1_Missense_Mutation_p.A421V|ASXL2_ENST00000336112.4_Missense_Mutation_p.A653V			Q76L83	ASXL2_HUMAN	additional sex combs like 2 (Drosophila)	681	Ala-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(7)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(3)	33	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGCGGCTGCAGCAGCTGCGGC	0.607000													27	57					0	0	1	0	0
DPY19L2P2	349152	broad.mit.edu	37	7	102895269	102895269	+	RNA	SNP	G	G	T			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr7:102895269G>T	ENST00000312132.4	-	0	2575																											CCCATCATTAGTCCATTTAAA	0.328000													11	23					0.00010058	0.000103063	1	1	0
KIAA0100	9703	broad.mit.edu	37	17	26961786	26961786	+	Missense_Mutation	SNP	C	C	T	rs149314530		TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr17:26961786C>T	ENST00000528896.2	-	16	2893	c.2819G>A	c.(2818-2820)cGc>cAc	p.R940H	KIAA0100_ENST00000544884.1_Missense_Mutation_p.R797H|RP11-192H23.7_ENST00000577814.1_RNA|KIAA0100_ENST00000389003.3_Missense_Mutation_p.R797H	NM_014680.3	NP_055495.2	Q14667	K0100_HUMAN	KIAA0100	940						extracellular region				breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(23)|ovary(2)|prostate(2)|skin(6)|stomach(2)|urinary_tract(3)	68	Lung NSC(42;0.00431)					AATGTTTTTGCGTTCCAAAGA	0.532000													4	110					0	0	1	0	0
CSN1S1	1446	broad.mit.edu	37	4	70810654	70810654	+	Silent	SNP	G	G	A			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr4:70810654G>A	ENST00000246891.4	+	15	538	c.489G>A	c.(487-489)ccG>ccA	p.P163P	CSN1S1_ENST00000505782.1_Silent_p.P147P|CSN1S1_ENST00000507772.1_Silent_p.P155P|CSN1S1_ENST00000444405.3_Silent_p.P154P|CSN1S1_ENST00000507763.1_Silent_p.P154P	NM_001890.1	NP_001881.1	P47710	CASA1_HUMAN	casein alpha s1	163						extracellular region	protein binding|transporter activity			lung(5)|prostate(1)|upper_aerodigestive_tract(1)	7						CTTTCCCACCGTTTTCCGACA	0.413000													37	82					0	0	1	0	0
C9	735	broad.mit.edu	37	5	39311307	39311307	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr5:39311307C>A	ENST00000263408.4	-	7	1138	c.1043G>T	c.(1042-1044)aGc>aTc	p.S348I		NM_001737.3	NP_001728.1	P02748	CO9_HUMAN	complement component 9	348	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis|hemolysis by symbiont of host erythrocytes	extracellular region|membrane attack complex				central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(17)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	32	all_lung(31;0.000197)	all_neural(839;7.57e-10)|Lung NSC(810;2.62e-08)|Ovarian(839;0.00384)|Breast(839;0.0184)|Myeloproliferative disorder(839;0.0511)	Epithelial(62;0.158)			AGACCCAGAGCTACTGTAGTG	0.383000													15	48					4.93089e-13	5.24697e-13	1	1	0
CD163	9332	broad.mit.edu	37	12	7640064	7640064	+	Silent	SNP	C	C	T			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr12:7640064C>T	ENST00000359156.4	-	8	2143	c.1941G>A	c.(1939-1941)agG>agA	p.R647R	CD163_ENST00000396620.3_Silent_p.R680R|CD163_ENST00000541972.1_Silent_p.R635R|CD163_ENST00000432237.2_Silent_p.R647R	NM_004244.5	NP_004235.4	Q86VB7	C163A_HUMAN	CD163 molecule	647	SRCR 6.				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(6)|pancreas(2)|prostate(1)|skin(5)|urinary_tract(4)	76						GAAACATATGCCTCCAGATCT	0.483000													20	46					0	0	1	0	0
ELMOD2	255520	broad.mit.edu	37	4	141458650	141458650	+	Silent	SNP	G	G	A			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr4:141458650G>A	ENST00000323570.3	+	5	486	c.354G>A	c.(352-354)agG>agA	p.R118R		NM_153702.3	NP_714913.1	Q8IZ81	ELMD2_HUMAN	ELMO/CED-12 domain containing 2	118					phagocytosis|regulation of defense response to virus|response to virus	cytoskeleton	GTPase activator activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)|upper_aerodigestive_tract(1)	7	all_hematologic(180;0.162)					TGAGGAAAAGGCCATATGATT	0.328000													3	38					0	0	1	0	0
LOC220729	220729	broad.mit.edu	37	3	197348674	197348674	+	RNA	SNP	A	A	G	rs144273946	by1000genomes	TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr3:197348674A>G	ENST00000418868.1	-	0	585					NR_003266.2																						GGCTCTGTCCACCAAATGCAC	0.478000													5	89					0	0	1	0	0
TECRL	253017	broad.mit.edu	37	4	65188478	65188478	+	Missense_Mutation	SNP	G	G	T	rs139611710		TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr4:65188478G>T	ENST00000381210.3	-	4	474	c.364C>A	c.(364-366)Caa>Aaa	p.Q122K	TECRL_ENST00000507440.1_Missense_Mutation_p.Q122K	NM_001010874.4	NP_001010874.2	Q5HYJ1	TECRL_HUMAN	trans-2,3-enoyl-CoA reductase-like	122					lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors			endometrium(2)|kidney(5)|large_intestine(7)|lung(30)|prostate(1)|skin(1)|stomach(1)	47						GCAATACTTTGAATGGTAATG	0.318000													21	48					9.86323e-18	1.06318e-17	1	1	0
MAGEA12	4111	broad.mit.edu	37	X	151900154	151900154	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chrX:151900154G>A	ENST00000393900.3	-	3	1000	c.647C>T	c.(646-648)gCc>gTc	p.A216V	CSAG4_ENST00000361201.4_RNA|MAGEA12_ENST00000393869.3_Missense_Mutation_p.A216V|MAGEA12_ENST00000357916.4_Missense_Mutation_p.A216V	NM_001166386.1	NP_001159858.1	P43365	MAGAC_HUMAN	melanoma antigen family A, 12	216	MAGE.									breast(5)|large_intestine(5)|liver(1)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Acute lymphoblastic leukemia(192;6.56e-05)					CTCCTCAGGGGCACAGTCGCC	0.572000													4	206					0	0	1	0	0
SIRPB1	10326	broad.mit.edu	37	20	1559173	1559173	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr20:1559173T>C	ENST00000381605.4	-	2	308	c.244A>G	c.(244-246)Aaa>Gaa	p.K82E	SIRPB1_ENST00000262929.5_Missense_Mutation_p.K81E|RP4-576H24.4_ENST00000564763.1_Missense_Mutation_p.K82E|SIRPB1_ENST00000381603.3_Missense_Mutation_p.K82E	NM_006065.3	NP_006056.2	O00241	SIRB1_HUMAN	signal-regulatory protein beta 1	82	Ig-like V-type.				cell junction assembly|cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding			central_nervous_system(2)|kidney(2)|large_intestine(4)|lung(16)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	31						TGGCCTTCTTTCTGATTGTAG	0.522000													28	65					0	0	1	0	0
ZNF493	284443	broad.mit.edu	37	19	21606455	21606455	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr19:21606455A>G	ENST00000392288.2	+	4	1103	c.994A>G	c.(994-996)Att>Gtt	p.I332V	ZNF493_ENST00000355504.4_Missense_Mutation_p.I204V|CTD-2561J22.3_ENST00000600810.1_Intron	NM_001076678.2	NP_001070146.1	Q6ZR52	ZN493_HUMAN	zinc finger protein 493	204					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	30						AGCCTTTAGTATTTTCTCAAC	0.353000													32	57					0	0	1	0	0
M1AP	130951	broad.mit.edu	37	2	74867252	74867252	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr2:74867252G>C	ENST00000290536.5	-	2	267	c.151C>G	c.(151-153)Cta>Gta	p.L51V	M1AP_ENST00000536235.1_Missense_Mutation_p.L51V|M1AP_ENST00000358434.2_5'UTR|M1AP_ENST00000409585.1_Missense_Mutation_p.L51V	NM_001281296.1|NM_138804.3	NP_001268225.1|NP_620159.2			meiosis 1 associated protein																		CTGCAGGCTAGAGAGAAGAAG	0.517000													17	20					0	0	1	0	0
WFDC11	259239	broad.mit.edu	37	20	44277950	44277950	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr20:44277950G>C	ENST00000356562.2	-	4	410	c.189C>G	c.(187-189)gaC>gaG	p.D63E	WFDC11_ENST00000324384.3_Missense_Mutation_p.D63E			Q8NEX6	WFD11_HUMAN	WAP four-disulfide core domain 11	63						extracellular region				endometrium(1)|lung(4)	5		Myeloproliferative disorder(115;0.0122)				TGTAATTTTTGTCTTTACATC	0.393000													4	181					0	0	1	0	0
CWC27	10283	broad.mit.edu	37	5	64077826	64077826	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr5:64077826G>A	ENST00000508024.1	+	3	419	c.218G>A	c.(217-219)aGt>aAt	p.S73N	CWC27_ENST00000381070.3_Missense_Mutation_p.S73N			Q6UX04	CWC27_HUMAN	CWC27 spliceosome-associated protein homolog (S. cerevisiae)	73	PPIase cyclophilin-type.				protein folding	catalytic step 2 spliceosome	peptidyl-prolyl cis-trans isomerase activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(5)|prostate(1)	21						GGCACAGGGAGTGGTGGAGAG	0.328000													11	22					0	0	1	0	0
AHDC1	27245	broad.mit.edu	37	1	27877008	27877008	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr1:27877008G>T	ENST00000374011.2	-	6	2587	c.1619C>A	c.(1618-1620)cCc>cAc	p.P540H	AHDC1_ENST00000247087.5_Missense_Mutation_p.P540H	NM_001029882.2	NP_001025053.1	Q5TGY3	AHDC1_HUMAN	AT hook, DNA binding motif, containing 1	540							DNA binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(8)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	42		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;8.48e-25)|Colorectal(126;9.17e-09)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00192)|BRCA - Breast invasive adenocarcinoma(304;0.00259)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0291)		GAGAATAATGGGCATCTCACC	0.637000													4	31					1	1	1	1	0
ELAC1	55520	broad.mit.edu	37	18	48510473	48510473	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr18:48510473T>G	ENST00000269466.3	+	3	272	c.165T>G	c.(163-165)atT>atG	p.I55M	SMAD4_ENST00000452201.2_Intron|RP11-729L2.2_ENST00000588256.1_Intron|ELAC1_ENST00000588577.1_Intron|RP11-729L2.2_ENST00000590722.2_Intron|ELAC1_ENST00000591429.1_Missense_Mutation_p.I55M	NM_018696.2	NP_061166.1	Q9H777	RNZ1_HUMAN	elaC ribonuclease Z 1	55					tRNA 3'-trailer cleavage	nucleus	endoribonuclease activity, producing 5'-phosphomonoesters|metal ion binding			kidney(1)|large_intestine(4)|prostate(1)	6		Colorectal(6;0.0269)|all_epithelial(6;0.0729)		Colorectal(21;0.000943)|COAD - Colon adenocarcinoma(17;0.0398)|READ - Rectum adenocarcinoma(32;0.0894)|STAD - Stomach adenocarcinoma(97;0.18)		AAGGGAGAATTACCAAGATCT	0.398000													15	28					0	0	1	0	0
HCAR2	338442	broad.mit.edu	37	12	123187180	123187180	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr12:123187180C>G	ENST00000328880.5	-	1	710	c.651G>C	c.(649-651)caG>caC	p.Q217H	HCAR1_ENST00000356987.2_Intron|RP11-324E6.6_ENST00000543611.1_lincRNA	NM_177551.3	NP_808219.1	Q8TDS4	HCAR2_HUMAN	hydroxycarboxylic acid receptor 2	217					negative regulation of lipid catabolic process|neutrophil apoptosis|positive regulation of adiponectin secretion|positive regulation of neutrophil apoptosis	integral to membrane|plasma membrane	nicotinic acid receptor activity|purinergic nucleotide receptor activity, G-protein coupled			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(5)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	15					Mepenzolate(DB04843)|Niacin(DB00627)	CCATTTGTCTCTGCCGCAGGC	0.547000													19	25					0	0	1	0	0
DAPK2	23604	broad.mit.edu	37	15	64275784	64275784	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr15:64275784T>C	ENST00000261891.3	-	2	267	c.262A>G	c.(262-264)Acg>Gcg	p.T88A	DAPK2_ENST00000457488.1_Missense_Mutation_p.T88A|DAPK2_ENST00000558069.1_Missense_Mutation_p.T88A|DAPK2_ENST00000558482.1_5'UTR			Q9UIK4	DAPK2_HUMAN	death-associated protein kinase 2	88	Protein kinase.				apoptosis|induction of apoptosis|intracellular protein kinase cascade	cytoplasm	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity|identical protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|skin(1)|stomach(1)	11				LUAD - Lung adenocarcinoma(2;0.215)		TCGTGCAGCGTGATGACATTG	0.667000													13	29					0	0	1	0	0
PPIP5K2	23262	broad.mit.edu	37	5	102482329	102482329	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr5:102482329G>A	ENST00000321521.9	+	6	1159	c.586G>A	c.(586-588)Gtt>Att	p.V196I	PPIP5K2_ENST00000414217.1_Missense_Mutation_p.V196I|PPIP5K2_ENST00000513500.1_3'UTR|PPIP5K2_ENST00000358359.3_Missense_Mutation_p.V196I			O43314	VIP2_HUMAN	diphosphoinositol pentakisphosphate kinase 2	196					inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	42						AGATCACAATGTTTACATTTA	0.358000													29	56					0	0	1	0	0
CCDC115	84317	broad.mit.edu	37	2	131098520	131098520	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr2:131098520G>T	ENST00000259229.2	-	4	614	c.391C>A	c.(391-393)Cct>Act	p.P131T	CCDC115_ENST00000409127.1_Missense_Mutation_p.P126T|CCDC115_ENST00000437688.2_Missense_Mutation_p.P126T	NM_032357.2	NP_115733.2	Q96NT0	CC115_HUMAN	coiled-coil domain containing 115	131						endosome|lysosome				central_nervous_system(1)|large_intestine(2)|lung(3)|prostate(1)	7	Colorectal(110;0.1)					AGACTGTGAGGAACTAGGATT	0.587000													3	32					0.004672	0.00472898	1	1	0
HEPH	9843	broad.mit.edu	37	X	65474950	65474950	+	Silent	SNP	C	C	T			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chrX:65474950C>T	ENST00000519389.1	+	16	2978	c.2799C>T	c.(2797-2799)tcC>tcT	p.S933S	HEPH_ENST00000419594.1_Silent_p.S690S|HEPH_ENST00000441993.2_Silent_p.S882S|HEPH_ENST00000374727.3_Silent_p.S882S|HEPH_ENST00000343002.2_Silent_p.S879S|HEPH_ENST00000336279.5_Silent_p.S612S			Q9BQS7	HEPH_HUMAN	hephaestin	879	Plastocyanin-like 6.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|lung(56)|ovary(5)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	89						CTTGTGTTTCCTGGATCTATT	0.483000													11	31					0	0	1	0	0
TRRAP	8295	broad.mit.edu	37	7	98529037	98529037	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr7:98529037G>A	ENST00000359863.4	+	26	3810	c.3601G>A	c.(3601-3603)Ggg>Agg	p.G1201R	TRRAP_ENST00000355540.3_Missense_Mutation_p.G1201R|TRRAP_ENST00000446306.3_Missense_Mutation_p.G1200R	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	1201					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			GGTTTCCAATGGGGCAGTCGC	0.562000													10	16					0	0	1	0	0
ECI2	10455	broad.mit.edu	37	6	4126385	4126385	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr6:4126385T>G	ENST00000465828.1	-	6	853	c.568A>C	c.(568-570)Aat>Cat	p.N190H	C6orf201_ENST00000333388.5_Intron|ECI2_ENST00000380118.3_Missense_Mutation_p.N220H|ECI2_ENST00000380125.2_Missense_Mutation_p.N190H|C6orf201_ENST00000380175.4_Intron|ECI2_ENST00000413766.2_Missense_Mutation_p.N53H|ECI2_ENST00000361538.2_Missense_Mutation_p.N190H			O75521	ECI2_HUMAN	enoyl-CoA delta isomerase 2	220	ECH-like.				fatty acid metabolic process	mitochondrion|peroxisomal matrix	dodecenoyl-CoA delta-isomerase activity|fatty-acyl-CoA binding			endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(1)	11						AAAACGGCATTATTTTTAGCT	0.398000													20	31					0	0	1	0	0
PI16	221476	broad.mit.edu	37	6	36931309	36931309	+	Silent	SNP	C	C	T			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr6:36931309C>T	ENST00000373674.3	+	5	1519	c.1191C>T	c.(1189-1191)tcC>tcT	p.S397S	PI16_ENST00000491324.1_Intron	NM_001199159.1|NM_153370.2	NP_001186088.1|NP_699201.2	Q6UXB8	PI16_HUMAN	peptidase inhibitor 16	397						extracellular region|integral to membrane	peptidase inhibitor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(13)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						CCTCCAAGTCCCTGCCCAATT	0.612000													17	27					0	0	1	0	0
MORF4L1	10933	broad.mit.edu	37	15	79172899	79172899	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr15:79172899C>G	ENST00000331268.5	+	3	337	c.133C>G	c.(133-135)Cat>Gat	p.H45D	MORF4L1_ENST00000426013.2_Missense_Mutation_p.H45D|MORF4L1_ENST00000379535.4_Missense_Mutation_p.H70D|MORF4L1_ENST00000558502.1_Intron|MORF4L1_ENST00000558746.1_Missense_Mutation_p.H45D|MORF4L1_ENST00000559345.1_5'UTR|MORF4L1_ENST00000561171.1_3'UTR	NM_206839.2	NP_996670.1	Q9UBU8	MO4L1_HUMAN	mortality factor 4 like 1	45	Interaction with MYST1.				double-strand break repair via homologous recombination|histone deacetylation|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|Sin3 complex	protein N-terminus binding			breast(1)|large_intestine(3)|lung(4)|prostate(1)|urinary_tract(1)	10						ATACTTCATACATTACAGTGG	0.299000													15	30					0	0	1	0	0
DDX52	11056	broad.mit.edu	37	17	35986098	35986098	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr17:35986098C>T	ENST00000349699.2	-	8	1022	c.979G>A	c.(979-981)Ggc>Agc	p.G327S	DDX52_ENST00000394367.3_Missense_Mutation_p.G219S	NM_007010.3	NP_008941.2	Q9Y2R4	DDX52_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 52	327	Helicase ATP-binding.					nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			biliary_tract(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(5)|ovary(1)|skin(3)	17		Breast(25;0.00637)|Ovarian(249;0.15)				CCAGTTTTGCCATCTTCAAAC	0.423000													12	39					0	0	1	0	0
C9orf96	169436	broad.mit.edu	37	9	136260780	136260780	+	Silent	SNP	G	G	A			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr9:136260780G>A	ENST00000371957.3	+	9	863	c.756G>A	c.(754-756)ctG>ctA	p.L252L	C9orf96_ENST00000371955.1_5'UTR	NM_153710.3	NP_714921.4	Q8NE28	SGK71_HUMAN	chromosome 9 open reading frame 96	252	Protein kinase.						ATP binding|protein kinase activity			autonomic_ganglia(1)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(5)|lung(10)|ovary(2)|stomach(2)	25				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		CAGGCAGCCTGAAGGCCGTCC	0.552000													16	28					0	0	1	0	0
ZBTB17	7709	broad.mit.edu	37	1	16272308	16272308	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr1:16272308G>A	ENST00000375733.2	-	6	801	c.563C>T	c.(562-564)gCg>gTg	p.A188V	ZBTB17_ENST00000537142.1_Missense_Mutation_p.A106V|ZBTB17_ENST00000448462.2_Missense_Mutation_p.A125V|ZBTB17_ENST00000375743.4_Missense_Mutation_p.A188V			Q13105	ZBT17_HUMAN	zinc finger and BTB domain containing 17	188					negative regulation of cell cycle	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(4)|large_intestine(1)|lung(4)|ovary(2)|prostate(2)	15		Colorectal(325;0.000257)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|Colorectal(212;4.12e-07)|COAD - Colon adenocarcinoma(227;2.43e-05)|BRCA - Breast invasive adenocarcinoma(304;9.97e-05)|Kidney(64;0.000182)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0649)		CTCCCGGGGCGCATCGGCTTT	0.662000													3	34					0	0	1	0	0
AUNIP	79000	broad.mit.edu	37	1	26163989	26163992	+	Frame_Shift_Del	DEL	CTTT	CTTT	-			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr1:26163989_26163992delCTTT	ENST00000374298.3	-	2	186_189	c.132_135delAAAG	c.(130-135)agaaagfs	p.RK44fs	AUNIP_ENST00000481602.1_5'UTR|AUNIP_ENST00000538789.1_Frame_Shift_Del_p.RK44fs	NM_024037.1	NP_076942.1			aurora kinase A and ninein interacting protein																		AAATATTAGCCTTTCTTTCTCCAG	0.387													40	22	---	---	---	---					
ARID1A	8289	broad.mit.edu	37	1	27057807	27057810	+	Frame_Shift_Del	DEL	GTCT	GTCT	-			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr1:27057807_27057810delGTCT	ENST00000324856.7	+	3	1886_1889	c.1515_1518delGTCT	c.(1513-1518)cagtctfs	p.QS505fs	ARID1A_ENST00000374152.2_Frame_Shift_Del_p.QS122fs|ARID1A_ENST00000457599.2_Frame_Shift_Del_p.QS505fs	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	505					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding		ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		AGCAGCCACAGTCTCAACCACCAC	0.618			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								107	44	---	---	---	---					
ELF3	1999	broad.mit.edu	37	1	201982339	201982339	+	Frame_Shift_Del	DEL	C	C	-			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr1:201982339delC	ENST00000359651.3	+	6	3910	c.718delC	c.(718-720)cccfs	p.P240fs	ELF3_ENST00000367284.5_Frame_Shift_Del_p.P240fs|RP11-510N19.5_ENST00000504773.1_RNA|ELF3_ENST00000367283.3_Frame_Shift_Del_p.P240fs			P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription factor, epithelial-specific )	240					epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(2)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	20						GAAGGGGGATCCCAAGCACGG	0.602													13	37	---	---	---	---					
PRRT3	285368	broad.mit.edu	37	3	9991858	9991859	+	Splice_Site	INS	-	-	A			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr3:9991858_9991859insA	ENST00000412055.1	-	2	73		c.e2-2		PRRT3-AS1_ENST00000431558.1_RNA|PRRT3_ENST00000411976.2_Splice_Site	NM_207351.3	NP_997234.3	Q5FWE3	PRRT3_HUMAN	proline-rich transmembrane protein 3							integral to membrane				NS(2)|breast(1)|endometrium(3)|large_intestine(3)|lung(1)|skin(1)|stomach(2)	13						TGGATGAGCCTAAAAAAAAAAC	0.574													2	4	---	---	---	---					
FAT1	2195	broad.mit.edu	37	4	187539279	187539300	+	Frame_Shift_Del	DEL	TTTCAACAATGAATGCCTCATA	TTTCAACAATGAATGCCTCATA	-			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr4:187539279_187539300delTTTCAACAATGAATGCCTCATA	ENST00000441802.2	-	10	8649_8670	c.8440_8461delTATGAGGCATTCATTGTTGAAA	c.(8440-8463)tatgaggcattcattgttgaaaacfs	p.YEAFIVEN2814fs		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	2814	Cadherin 26.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						CCTGGCAGGTTTTCAACAATGAATGCCTCATATGGACTAGAT	0.455										HNSCC(5;0.00058)			12	84	---	---	---	---					
ARID1B	57492	broad.mit.edu	37	6	157528434	157528434	+	Frame_Shift_Del	DEL	G	G	-			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr6:157528434delG	ENST00000346085.5	+	20	6160	c.6159delG	c.(6157-6159)ctgfs	p.L2053fs	ARID1B_ENST00000275248.4_Frame_Shift_Del_p.L2035fs|ARID1B_ENST00000367148.1_Frame_Shift_Del_p.L2093fs|ARID1B_ENST00000350026.5_Frame_Shift_Del_p.L2040fs	NM_020732.3	NP_065783.3	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	2040					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			NS(2)|breast(5)|central_nervous_system(4)|endometrium(12)|kidney(4)|large_intestine(11)|lung(30)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(3)	81		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		ATGGCTTGCTGCACTGGATGG	0.547													51	61	---	---	---	---					
ABL1	25	broad.mit.edu	37	9	133759490	133759492	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr9:133759490_133759492delAAG	ENST00000318560.5	+	11	2194_2196	c.1813_1815delAAG	c.(1813-1815)aagdel	p.K609del		NM_005157.4	NP_005148.2	P00519	ABL1_HUMAN	c-abl oncogene 1, non-receptor tyrosine kinase	609	Poly-Lys.				actin cytoskeleton organization|axon guidance|blood coagulation|cell adhesion|DNA damage induced protein phosphorylation|DNA damage response, signal transduction resulting in induction of apoptosis|mismatch repair|muscle cell differentiation|negative regulation of protein serine/threonine kinase activity|peptidyl-tyrosine phosphorylation|positive regulation of muscle cell differentiation|positive regulation of oxidoreductase activity|regulation of transcription involved in S phase of mitotic cell cycle	cytoskeleton|cytosol|nuclear membrane|nucleolus|perinuclear region of cytoplasm	ATP binding|DNA binding|magnesium ion binding|manganese ion binding|mitogen-activated protein kinase binding|non-membrane spanning protein tyrosine kinase activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding			breast(3)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1149)|kidney(3)|large_intestine(7)|lung(15)|ovary(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	1195		all_hematologic(13;0.0361)|Acute lymphoblastic leukemia(5;0.0543)|Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.4e-05)	Adenosine triphosphate(DB00171)|Dasatinib(DB01254)|Imatinib(DB00619)	CGCCTTGATCAAGAAGAAGAAGA	0.616			"""T, Mis"""	"""BCR, ETV6, NUP214"""	"""CML, ALL, T-ALL"""								7	98	---	---	---	---					
ZFP36L1	677	broad.mit.edu	37	14	69256668	69256669	+	Frame_Shift_Ins	INS	-	-	GC			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr14:69256668_69256669insGC	ENST00000439696.2	-	2	899_900	c.598_599insGC	c.(598-600)catfs	p.H200fs	ZFP36L1_ENST00000336440.3_Frame_Shift_Ins_p.H200fs|ZFP36L1_ENST00000555997.1_3'UTR	NM_001244701.1|NM_004926.3	NP_001231630.1|NP_004917.2	Q07352	TISB_HUMAN	ZFP36 ring finger protein-like 1	200					regulation of mRNA stability	cytosol|nucleus	DNA binding|mRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|kidney(1)|large_intestine(1)|liver(2)|lung(9)|ovary(1)|prostate(2)|urinary_tract(1)	21				all cancers(60;0.00203)|BRCA - Breast invasive adenocarcinoma(234;0.00205)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		GCTAAAGCTATGCTGGAGGCGG	0.688											OREG0022753	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	29	---	---	---	---					
CDC27	996	broad.mit.edu	37	17	45219612	45219612	+	Frame_Shift_Del	DEL	A	A	-			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr17:45219612delA	ENST00000066544.3	-	11	1454	c.1361delT	c.(1360-1362)ctafs	p.L454fs	CDC27_ENST00000446365.2_Frame_Shift_Del_p.L393fs|CDC27_ENST00000527547.1_Frame_Shift_Del_p.L454fs|CDC27_ENST00000531206.1_Frame_Shift_Del_p.L460fs	NM_001114091.1|NM_001256.3	NP_001107563.1|NP_001247.3	P30260	CDC27_HUMAN	cell division cycle 27	454					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(17)|large_intestine(18)|lung(11)|ovary(5)|pancreas(1)|prostate(19)|skin(5)|upper_aerodigestive_tract(2)	90						TGCTTTTTGTAGATTAAAGGC	0.308													7	32	---	---	---	---					
RAVER1	125950	broad.mit.edu	37	19	10431432	10431434	+	In_Frame_Del	DEL	TGC	TGC	-			TCGA-ZF-AA5N-01A-11D-A42E-08	TCGA-ZF-AA5N-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5d5193dc-1d1d-4119-a181-544c7fc4bbc8	7dc7520f-3483-4949-980c-ecd0549dfc81	g.chr19:10431432_10431434delTGC	ENST00000293677.6	-	9	1799_1801	c.1718_1720delGCA	c.(1717-1722)agcaaa>aaa	p.S573del		NM_133452.2	NP_597709.2	Q8IY67	RAVR1_HUMAN	ribonucleoprotein, PTB-binding 1	433						cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding			breast(1)|endometrium(3)|large_intestine(1)|lung(8)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	18			OV - Ovarian serous cystadenocarcinoma(20;1.81e-09)|Epithelial(33;3.65e-06)|all cancers(31;8.35e-06)			TGGAAGGCTTTGCTGCTGCTGCT	0.704													4	9	---	---	---	---