Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SNRNP200	23020	broad.mit.edu	37	2	96967415	96967415	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:96967415C>A	ENST00000323853.5	-	4	498	c.421G>T	c.(421-423)Gct>Tct	p.A141S	SNRNP200_ENST00000349783.5_Missense_Mutation_p.A141S	NM_014014.4	NP_054733.2	O75643	U520_HUMAN	small nuclear ribonucleoprotein 200kDa (U5)	141						catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|lung(37)|ovary(7)|prostate(4)|skin(5)|stomach(1)|urinary_tract(1)	90						TTTAGAACAGCTAGAACTTCA	0.463000													4	87					0.014758	0.0148657	1	1	0
BCL11B	64919	broad.mit.edu	37	14	99724032	99724032	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr14:99724032C>T	ENST00000345514.2	-	2	469	c.203G>A	c.(202-204)gGg>gAg	p.G68E	BCL11B_ENST00000357195.3_Missense_Mutation_p.G68E|BCL11B_ENST00000443726.2_Intron	NM_001282238.1|NM_022898.1	NP_001269167.1|NP_075049.1	Q9C0K0	BC11B_HUMAN	B-cell CLL/lymphoma 11B (zinc finger protein)	0						nucleus	zinc ion binding			NS(3)|breast(1)|central_nervous_system(9)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(9)|prostate(2)|skin(2)	34		Melanoma(154;0.0866)|all_epithelial(191;0.241)		COAD - Colon adenocarcinoma(157;0.103)		CAGGATGTCCCCCAAGGGGAA	0.602000			T	TLX3	T-ALL								40	18					0	0	1	0	0
DMRT3	58524	broad.mit.edu	37	9	990830	990830	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr9:990830C>T	ENST00000190165.2	+	2	1282	c.1244C>T	c.(1243-1245)tCt>tTt	p.S415F		NM_021240.2	NP_067063.1	Q9NQL9	DMRT3_HUMAN	doublesex and mab-3 related transcription factor 3	415					cell differentiation|multicellular organismal development|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|large_intestine(5)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	26		all_lung(10;1.39e-08)|Lung NSC(10;1.42e-08)		Lung(218;0.0196)		CCCAGTAACTCTACCAGCGTC	0.557000													39	43					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152737662	152737662	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr6:152737662C>G	ENST00000367255.5	-	41	6511	c.5910G>C	c.(5908-5910)caG>caC	p.Q1970H	SYNE1_ENST00000265368.4_Missense_Mutation_p.Q1970H|SYNE1_ENST00000341594.5_Missense_Mutation_p.Q2007H|SYNE1_ENST00000423061.1_Missense_Mutation_p.Q1977H|SYNE1_ENST00000448038.1_Missense_Mutation_p.Q1977H	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1970					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTGCCTCACTCTGCTTGGTTC	0.493000										HNSCC(10;0.0054)			48	163					0	0	1	0	0
P2RX3	5024	broad.mit.edu	37	11	57114101	57114101	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr11:57114101G>A	ENST00000263314.2	+	2	237	c.203G>A	c.(202-204)gGa>gAa	p.G68E		NM_002559.3	NP_002550.2	P56373	P2RX3_HUMAN	purinergic receptor P2X, ligand-gated ion channel, 3	68					positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling	integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity			endometrium(4)|kidney(2)|large_intestine(4)|lung(15)|prostate(1)	26						AAGGGCTCCGGACTCTACGCC	0.567000													9	42					0	0	1	0	0
PLEKHG4B	153478	broad.mit.edu	37	5	162003	162003	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr5:162003G>C	ENST00000283426.6	+	10	1575	c.1525G>C	c.(1525-1527)Gag>Cag	p.E509Q		NM_052909.3	NP_443141.3	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 4B	509					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			endometrium(1)|large_intestine(2)|lung(2)|prostate(3)|skin(3)	11			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		CAGCCAGGCTGAGTGCAGGGA	0.632000													8	486					0	0	1	0	0
TRIM56	81844	broad.mit.edu	37	7	100730774	100730774	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr7:100730774G>C	ENST00000306085.6	+	3	478	c.181G>C	c.(181-183)Gag>Cag	p.E61Q		NM_030961.1	NP_112223.1	Q9BRZ2	TRI56_HUMAN	tripartite motif containing 56	61					defense response to virus|interferon-beta production|protein K63-linked ubiquitination|response to type I interferon	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(4)|lung(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	Lung NSC(181;0.136)|all_lung(186;0.182)					CGAGTGCCGCGAGACAGTGCC	0.672000													16	51					0	0	1	0	0
SPATA7	55812	broad.mit.edu	37	14	88899525	88899525	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr14:88899525G>A	ENST00000556553.1	+	10	1592	c.1033G>A	c.(1033-1035)Gaa>Aaa	p.E345K	SPATA7_ENST00000045347.7_Missense_Mutation_p.E377K|SPATA7_ENST00000393545.4_Missense_Mutation_p.E377K|SPATA7_ENST00000356583.5_Missense_Mutation_p.E345K			Q9P0W8	SPAT7_HUMAN	spermatogenesis associated 7	377					response to stimulus|visual perception					cervix(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)	18						TGTAACAGATGAAATTTTGAA	0.264000													12	5					0	0	1	0	0
NEU1	4758	broad.mit.edu	37	6	31827906	31827906	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr6:31827906C>G	ENST00000375631.4	-	5	1063	c.934G>C	c.(934-936)Gag>Cag	p.E312Q		NM_000434.3	NP_000425.1	Q99519	NEUR1_HUMAN	sialidase 1 (lysosomal sialidase)	312						cytoplasmic membrane-bounded vesicle|lysosomal lumen|lysosomal membrane|plasma membrane	exo-alpha-sialidase activity|protein binding			kidney(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)	10					Oseltamivir(DB00198)|Zanamivir(DB00558)	TCCACGAGCTCAGGGTCGAAG	0.562000													51	31					0	0	1	0	0
C9orf41	138199	broad.mit.edu	37	9	77631211	77631211	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr9:77631211A>T	ENST00000376834.3	-	3	715	c.563T>A	c.(562-564)aTt>aAt	p.I188N	C9orf41_ENST00000376837.3_Missense_Mutation_p.I188N	NM_152420.1	NP_689633.1	Q8N4J0	CI041_HUMAN	chromosome 9 open reading frame 41	188										endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)|skin(1)|urinary_tract(2)	17						ATTTTTTAAAATTTCTTTAAT	0.333000													20	71					0	0	1	0	0
LY9	4063	broad.mit.edu	37	1	160789143	160789143	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:160789143G>A	ENST00000368037.5	+	7	1591	c.1477G>A	c.(1477-1479)Gag>Aag	p.E493K	LY9_ENST00000392203.4_Missense_Mutation_p.E403K|LY9_ENST00000368040.1_Missense_Mutation_p.E145K|LY9_ENST00000341032.4_Missense_Mutation_p.E403K|LY9_ENST00000368041.2_Missense_Mutation_p.E363K|LY9_ENST00000263285.6_Missense_Mutation_p.E493K	NM_001261456.1|NM_002348.3	NP_001248385.1|NP_002339.2	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9						cell adhesion|immunoglobulin mediated immune response	integral to membrane				autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			CAGCCAAGCTGAGGCCCCAGC	0.488000													19	390					0	0	1	0	0
MMS22L	253714	broad.mit.edu	37	6	97626354	97626354	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr6:97626354C>T	ENST00000275053.4	-	18	2909	c.2644G>A	c.(2644-2646)Gaa>Aaa	p.E882K	MMS22L_ENST00000369251.2_Missense_Mutation_p.E842K	NM_198468.2	NP_940870.2	Q6ZRQ5	MMS22_HUMAN	MMS22-like, DNA repair protein	882					double-strand break repair via homologous recombination|replication fork processing	nuclear replication fork	protein binding			breast(1)|endometrium(9)|kidney(2)|large_intestine(12)|lung(20)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	50						TTAGGGTCTTCTGAGATGGAT	0.308000													8	46					0	0	1	0	0
VMP1	81671	broad.mit.edu	37	17	57812812	57812812	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr17:57812812A>G	ENST00000262291.4	+	3	500	c.190A>G	c.(190-192)Atc>Gtc	p.I64V	VMP1_ENST00000539763.1_Intron|VMP1_ENST00000536180.1_5'UTR|VMP1_ENST00000545362.1_Missense_Mutation_p.I64V|VMP1_ENST00000537567.1_5'UTR	NM_030938.3	NP_112200.2	Q96GC9	VMP1_HUMAN	vacuole membrane protein 1	64					autophagy|cell adhesion	endoplasmic reticulum|ER-Golgi intermediate compartment membrane|integral to membrane|plasma membrane|vacuolar membrane				breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(4)|skin(2)	16						AATCCTTGTAATCTTGAAGGA	0.398000													7	33					0	0	1	0	0
ARPC5	10092	broad.mit.edu	37	1	183604790	183604790	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:183604790G>A	ENST00000359856.6	-	1	71	c.5C>T	c.(4-6)tCg>tTg	p.S2L	ARPC5_ENST00000367534.1_Missense_Mutation_p.S2L|ARPC5_ENST00000294742.6_Missense_Mutation_p.S2L	NM_005717.3	NP_005708.1	O15511	ARPC5_HUMAN	actin related protein 2/3 complex, subunit 5, 16kDa	2					actin cytoskeleton organization|cellular component movement|regulation of actin filament polymerization	Arp2/3 protein complex|cell projection|cytoplasm	actin binding|structural constituent of cytoskeleton			cervix(1)|large_intestine(1)|lung(2)	4						TGTGTTCTTCGACATCCCAAT	0.607000													7	35					0	0	1	0	0
EDEM2	55741	broad.mit.edu	37	20	33735053	33735053	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr20:33735053G>A	ENST00000374492.3	-	1	114	c.9C>T	c.(7-9)ttC>ttT	p.F3F	EDEM2_ENST00000374491.3_Silent_p.F3F|EDEM2_ENST00000540582.1_Intron|EDEM2_ENST00000542871.1_5'UTR	NM_018217.2	NP_060687.2	Q9BV94	EDEM2_HUMAN	ER degradation enhancer, mannosidase alpha-like 2	3					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	endoplasmic reticulum lumen|endoplasmic reticulum membrane|extracellular region	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(10)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	22			BRCA - Breast invasive adenocarcinoma(18;0.00936)			TGAGCAGCCGGAAAGGCATAG	0.677000													4	20					0	0	1	0	0
RP11-704M14.1	0	broad.mit.edu	37	4	70080566	70080566	+	RNA	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr4:70080566G>A	ENST00000505646.1	+	0	730																											GGAGCATCCTGAGTACATGGA	0.318000													7	10					0	0	1	0	0
ZNF407	55628	broad.mit.edu	37	18	72346257	72346257	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr18:72346257C>T	ENST00000299687.5	+	1	3282	c.3282C>T	c.(3280-3282)atC>atT	p.I1094I	ZNF407_ENST00000577538.1_Silent_p.I1094I|ZNF407_ENST00000309902.6_Silent_p.I1094I|ZNF407_ENST00000582337.1_Silent_p.I1094I	NM_017757.2	NP_060227.2	Q9C0G0	ZN407_HUMAN	zinc finger protein 407	1094					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(21)|lung(23)|ovary(4)|prostate(3)|upper_aerodigestive_tract(2)	67		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		CCAAAAACATCATTATGCCTG	0.388000													12	22					0	0	1	0	0
CACNA2D2	9254	broad.mit.edu	37	3	50402600	50402600	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:50402600C>T	ENST00000435965.1	-	37	3308	c.3135G>A	c.(3133-3135)caG>caA	p.Q1045Q	CACNA2D2_ENST00000424201.2_Silent_p.Q1038Q|CACNA2D2_ENST00000360963.3_Silent_p.Q969Q|CACNA2D2_ENST00000423994.2_Silent_p.Q1046Q|CACNA2D2_ENST00000479441.1_Silent_p.Q1045Q|CACNA2D2_ENST00000429770.1_Silent_p.Q1039Q|CACNA2D2_ENST00000395083.1_Silent_p.Q1038Q|XXcos-LUCA11.5_ENST00000606589.1_Intron|CACNA2D2_ENST00000266039.3_Silent_p.Q1038Q			Q9NY47	CA2D2_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 2	1045					energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			breast(3)|cervix(1)|endometrium(4)|large_intestine(4)|lung(8)|ovary(2)|prostate(4)|skin(4)|urinary_tract(1)	31				BRCA - Breast invasive adenocarcinoma(193;0.000365)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)	Gabapentin(DB00996)	TGGTCAGTCTCTGCGCGTGGA	0.687000													11	40					0	0	1	0	0
LILRB1	10859	broad.mit.edu	37	19	55143203	55143203	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:55143203C>T	ENST00000396331.1	+	5	680	c.323C>T	c.(322-324)tCa>tTa	p.S108L	LILRB1_ENST00000448689.1_Missense_Mutation_p.S108L|LILRB1_ENST00000418536.2_Missense_Mutation_p.S108L|LILRB1_ENST00000434867.2_Missense_Mutation_p.S108L|LILRB1_ENST00000427581.2_Missense_Mutation_p.S144L|LILRB1_ENST00000396317.1_Missense_Mutation_p.S108L|LILRB1_ENST00000324602.7_Missense_Mutation_p.S108L|LILRB1_ENST00000396332.4_Missense_Mutation_p.S108L|LILRB1_ENST00000396327.3_Missense_Mutation_p.S108L|LILRB1_ENST00000396315.1_Missense_Mutation_p.S108L|LILRB1_ENST00000396321.2_Missense_Mutation_p.S108L	NM_006669.3	NP_006660.3	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	108	Ig-like C2-type 1.				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(38)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	74				GBM - Glioblastoma multiforme(193;0.0188)		GCAGGCCGCTCAGAGAGCAGT	0.622000										HNSCC(37;0.09)			44	76					0	0	1	0	0
COL9A1	1297	broad.mit.edu	37	6	71010049	71010049	+	Silent	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr6:71010049G>C	ENST00000357250.6	-	3	287	c.129C>G	c.(127-129)ctC>ctG	p.L43L	COL9A1_ENST00000370496.3_Silent_p.L43L	NM_001851.4	NP_001842.3	P20849	CO9A1_HUMAN	collagen, type IX, alpha 1	43	Nonhelical region (NC4).				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(44)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)	80						TCTTTGGACAGAGTTCATTTC	0.343000													17	51					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	215807871	215807871	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:215807871C>G	ENST00000366943.2	-	70	15613	c.15227G>C	c.(15226-15228)aGa>aCa	p.R5076T	USH2A_ENST00000307340.3_Missense_Mutation_p.R5076T			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	5076					maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding	p.R5076I(1)		NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CAAGGGAGGTCTTTCTCTGAT	0.443000										HNSCC(13;0.011)			10	49					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179613743	179613743	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:179613743C>T	ENST00000360870.5	-	46	13606	c.13384G>A	c.(13384-13386)Gaa>Aaa	p.E4462K	TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000589042.1_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Intron|TTN_ENST00000342992.6_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	590	Ig-like 24.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTTCAAATTCGATAATTCTA	0.348000													11	27					0	0	1	0	0
CDK12	51755	broad.mit.edu	37	17	37646961	37646961	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr17:37646961C>T	ENST00000447079.4	+	3	2116	c.2083C>T	c.(2083-2085)Cag>Tag	p.Q695*	CDK12_ENST00000430627.2_Nonsense_Mutation_p.Q695*	NM_015083.1|NM_016507.2	NP_055898.1|NP_057591.2	Q9NYV4	CDK12_HUMAN	cyclin-dependent kinase 12	695					mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			NS(4)|breast(3)|endometrium(5)|kidney(4)|large_intestine(11)|lung(23)|ovary(11)|prostate(4)|skin(2)|urinary_tract(3)	70						CACACCACCTCAGCAACCATA	0.458000			"""Mis, N, F"""		serous ovarian					TCGA Ovarian(9;0.13)			17	46					0	0	1	0	0
EPHB2	2048	broad.mit.edu	37	1	23208857	23208857	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:23208857T>C	ENST00000400191.3	+	6	1327	c.1309T>C	c.(1309-1311)Tcg>Ccg	p.S437P	EPHB2_ENST00000465676.1_3'UTR|EPHB2_ENST00000374627.1_Missense_Mutation_p.S431P|EPHB2_ENST00000374630.3_Missense_Mutation_p.S437P|EPHB2_ENST00000544305.1_Missense_Mutation_p.S437P|EPHB2_ENST00000374632.3_Missense_Mutation_p.S437P	NM_004442.6|NM_017449.3	NP_004433.2|NP_059145.2	P29323	EPHB2_HUMAN	EPH receptor B2	437	Fibronectin type-III 2.				axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(8)|stomach(1)|urinary_tract(1)	56		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		TCCAGCTCCATCGGCAGTGTC	0.612000													24	27					0	0	1	0	0
RSPH4A	345895	broad.mit.edu	37	6	116938321	116938321	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr6:116938321G>C	ENST00000229554.5	+	1	672	c.535G>C	c.(535-537)Gac>Cac	p.D179H	RSPH4A_ENST00000368580.4_Missense_Mutation_p.D179H|RSPH4A_ENST00000368581.4_Missense_Mutation_p.D179H	NM_001010892.2	NP_001010892.1	Q5TD94	RSH4A_HUMAN	radial spoke head 4 homolog A (Chlamydomonas)	179					cilium axoneme assembly|cilium movement	cytoplasm|cytoskeleton|radial spoke				breast(1)|endometrium(2)|kidney(1)|large_intestine(11)|lung(8)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27						GCTGAGATTTGACGTTTTTCA	0.502000									Kartagener syndrome				23	131					0	0	1	0	0
TPSD1	23430	broad.mit.edu	37	16	1306684	1306684	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr16:1306684G>A	ENST00000211076.3	+	2	398	c.250G>A	c.(250-252)Gaa>Aaa	p.E84K	TPSD1_ENST00000397534.2_Missense_Mutation_p.E77K	NM_012217.2	NP_036349.1	Q9BZJ3	TRYD_HUMAN	tryptase delta 1	84	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(9)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)	20		Hepatocellular(780;0.00369)				GCACTGCGTGGAACCGTGAGT	0.697000													11	37					0	0	1	0	0
LRBA	987	broad.mit.edu	37	4	151223904	151223904	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr4:151223904G>A	ENST00000535741.1	-	53	8363	c.7890C>T	c.(7888-7890)gtC>gtT	p.V2630V	LRBA_ENST00000357115.3_Silent_p.V2641V|LRBA_ENST00000510413.1_Silent_p.V2630V|LRBA_ENST00000503716.1_5'UTR			P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and anchor containing	2641						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(20)|lung(32)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	91	all_hematologic(180;0.151)					CAAGGCAAGTGACGACATCCC	0.373000													26	50					0	0	1	0	0
PTCHD2	57540	broad.mit.edu	37	1	11589878	11589878	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:11589878C>T	ENST00000294484.6	+	15	3102	c.2964C>T	c.(2962-2964)ttC>ttT	p.F988F	PTCHD2_ENST00000389575.3_Silent_p.F988F	NM_020780.1	NP_065831.1	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	988					cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			NS(3)|breast(2)|endometrium(9)|kidney(4)|large_intestine(5)|lung(34)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	76	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		CCTTCGGCTTCAACCCCTGCG	0.637000													13	31					0	0	1	0	0
EIF2AK2	5610	broad.mit.edu	37	2	37368823	37368823	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:37368823T>C	ENST00000233057.4	-	5	584	c.262A>G	c.(262-264)Aca>Gca	p.T88A	EIF2AK2_ENST00000405334.1_Missense_Mutation_p.T88A|EIF2AK2_ENST00000395127.2_Missense_Mutation_p.T88A	NM_001135651.2	NP_001129123.1	P19525	E2AK2_HUMAN	eukaryotic translation initiation factor 2-alpha kinase 2	88					evasion by virus of host immune response|modulation by virus of host cellular process|negative regulation of osteoblast proliferation|protein autophosphorylation|response to virus|viral infectious cycle	cytosol	ATP binding|double-stranded RNA binding|eukaryotic translation initiation factor 2alpha kinase activity|protein binding|protein phosphatase type 2A regulator activity			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(7)|ovary(2)|pancreas(1)	22		all_hematologic(82;0.248)				TTCGTTGTTGTCAATAATAAA	0.289000													13	35					0	0	1	0	0
HES1	3280	broad.mit.edu	37	3	193854187	193854187	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:193854187G>C	ENST00000232424.3	+	1	254	c.18G>C	c.(16-18)atG>atC	p.M6I		NM_005524.3	NP_005515.1	Q14469	HES1_HUMAN	hes family bHLH transcription factor 1	6					endocrine pancreas development|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway	nucleus	histone deacetylase binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)	6	all_cancers(143;7.3e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;3.65e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;1.48e-05)		CTGATATAATGGAGAAAAATT	0.403000													4	27					0	0	1	0	0
NKX2-5	1482	broad.mit.edu	37	5	172661786	172661786	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr5:172661786C>T	ENST00000329198.4	-	1	574	c.301G>A	c.(301-303)Gac>Aac	p.D101N	NKX2-5_ENST00000424406.2_Missense_Mutation_p.D101N|NKX2-5_ENST00000521848.1_Missense_Mutation_p.D101N	NM_001166175.1|NM_001166176.1|NM_004387.3	NP_001159647.1|NP_001159648.1|NP_004378.1	P52952	NKX25_HUMAN	NK2 homeobox 5	101	Ala/Pro-rich.				adult heart development|atrial cardiac muscle cell development|atrial septum morphogenesis|heart looping|hemopoiesis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cardiac muscle cell apoptosis|negative regulation of myotube differentiation|negative regulation of transcription from RNA polymerase II promoter|outflow tract septum morphogenesis|pharyngeal system development|positive regulation of calcium ion transport via voltage-gated calcium channel activity|positive regulation of cardioblast differentiation|positive regulation of cell proliferation|positive regulation of heart contraction|positive regulation of neuron differentiation|positive regulation of sodium ion transport|positive regulation of survival gene product expression|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription via serum response element binding|regulation of cardiac muscle contraction|right ventricular cardiac muscle tissue morphogenesis|septum secundum development|spleen development|thyroid gland development|vasculogenesis|ventricular septum morphogenesis		chromatin binding|protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|serum response element binding|transcription factor binding			breast(1)|central_nervous_system(1)|large_intestine(2)|lung(7)|prostate(1)	12	Renal(175;0.000159)|Lung NSC(126;0.00229)|all_lung(126;0.004)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			TTGGCTGGGTCGGGGTCGCTG	0.657000													11	20					0	0	1	0	0
ANKLE2	23141	broad.mit.edu	37	12	133306821	133306821	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr12:133306821C>T	ENST00000539605.1	-	10	8425	c.1741G>A	c.(1741-1743)Gaa>Aaa	p.E581K	ANKLE2_ENST00000357997.5_Missense_Mutation_p.E643K|ANKLE2_ENST00000542374.1_Intron|ANKLE2_ENST00000542657.1_5'UTR|ANKLE2_ENST00000542282.1_5'UTR			Q86XL3	ANKL2_HUMAN	ankyrin repeat and LEM domain containing 2	643						cytoplasm|integral to membrane|nuclear envelope				NS(2)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(4)|lung(20)|ovary(1)|urinary_tract(2)	45	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.3e-08)|Epithelial(86;1.56e-07)|all cancers(50;4.94e-06)		ATGTCATCTTCATCTAGAAAC	0.522000													18	55					0	0	1	0	0
GBF1	8729	broad.mit.edu	37	10	104128191	104128191	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr10:104128191G>A	ENST00000369983.3	+	22	3116	c.2856G>A	c.(2854-2856)caG>caA	p.Q952Q		NM_001199378.1|NM_001199379.1|NM_004193.2	NP_001186307.1|NP_001186308.1|NP_004184.1	Q92538	GBF1_HUMAN	golgi brefeldin A resistant guanine nucleotide exchange factor 1	952					COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|regulation of ARF protein signal transduction|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(14)|kidney(8)|large_intestine(15)|lung(19)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	71		Colorectal(252;0.0236)		Epithelial(162;5.16e-08)|all cancers(201;1.19e-06)		CAATCATCCAGAAAGCCATCT	0.512000													16	34					0	0	1	0	0
RASAL2	9462	broad.mit.edu	37	1	178420827	178420827	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:178420827C>T	ENST00000448150.3	+	10	2513	c.1695C>T	c.(1693-1695)ttC>ttT	p.F565F	RASAL2_ENST00000462775.1_Silent_p.F435F|RASAL2_ENST00000367649.3_Silent_p.F583F	NM_170692.2	NP_733793.2	Q9UJF2	NGAP_HUMAN	RAS protein activator like 2	435					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			biliary_tract(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(2)|lung(25)|ovary(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	54						AGCTGGCTTTCTGCAAGATCA	0.403000													21	82					0	0	1	0	0
BRD9	65980	broad.mit.edu	37	5	889796	889796	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr5:889796G>A	ENST00000323510.4	-	1	18	c.19C>T	c.(19-21)Ctt>Ttt	p.L7F	BRD9_ENST00000435709.2_Missense_Mutation_p.L7F|BRD9_ENST00000388890.4_Missense_Mutation_p.L7F|BRD9_ENST00000467963.1_Intron|BRD9_ENST00000483173.1_Intron			Q9H8M2	BRD9_HUMAN	bromodomain containing 9	0							nucleic acid binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|pancreas(1)|prostate(3)	29			Epithelial(17;0.00202)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00815)|Lung(60;0.185)			TTGAATACAAGACTTTGGTAT	0.423000													10	286					0	0	1	0	0
NDE1	54820	broad.mit.edu	37	16	15790665	15790665	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr16:15790665G>C	ENST00000396355.1	+	9	1721	c.895G>C	c.(895-897)Gat>Cat	p.D299H	NDE1_ENST00000342673.5_Missense_Mutation_p.D299H|NDE1_ENST00000396354.1_Missense_Mutation_p.D299H|NDE1_ENST00000396353.2_Missense_Mutation_p.D299H	NM_001143979.1	NP_001137451.1	Q9NXR1	NDE1_HUMAN	nudE neurodevelopment protein 1	299					cell differentiation|cell division|centrosome duplication|establishment of chromosome localization|establishment of mitotic spindle orientation|G2/M transition of mitotic cell cycle|mitotic prometaphase|nervous system development	cleavage furrow|condensed chromosome kinetochore|cytosol|microtubule|spindle pole centrosome	microtubule binding			endometrium(3)|kidney(3)|large_intestine(1)|lung(5)|ovary(1)	13						CAAGAACAGAGATGGCGGGGA	0.612000													14	93					0	0	1	0	0
ZNF630	57232	broad.mit.edu	37	X	47918067	47918067	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chrX:47918067T>C	ENST00000276054.4	-	5	2326	c.1392A>G	c.(1390-1392)atA>atG	p.I464M	ZNF630-AS1_ENST00000436124.1_RNA|ZNF630_ENST00000409324.3_Missense_Mutation_p.I588M|ZNF630_ENST00000442455.3_Missense_Mutation_p.I574M			Q2M218	ZN630_HUMAN	zinc finger protein 630	588					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(6)|lung(11)|ovary(1)	19						TTTTCTGATGTATAATGAGTG	0.408000													8	15					0	0	1	0	0
PGRMC1	10857	broad.mit.edu	37	X	118370404	118370404	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chrX:118370404C>T	ENST00000217971.7	+	1	189	c.78C>T	c.(76-78)ttC>ttT	p.F26F	PGRMC1_ENST00000535419.1_Silent_p.F26F	NM_006667.3	NP_006658.1	O00264	PGRC1_HUMAN	progesterone receptor membrane component 1	26						cell surface|endoplasmic reticulum membrane|integral to membrane|microsome|nucleolus	heme binding|protein binding|receptor activity|steroid binding			lung(6)	6						ATGAGATTTTCACGTCGCCGC	0.647000													11	16					0	0	1	0	0
SLITRK3	22865	broad.mit.edu	37	3	164906176	164906176	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:164906176C>G	ENST00000475390.1	-	2	2886	c.2443G>C	c.(2443-2445)Gag>Cag	p.E815Q	SLITRK3_ENST00000241274.3_Missense_Mutation_p.E815Q			O94933	SLIK3_HUMAN	SLIT and NTRK-like family, member 3	815						integral to membrane				NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(66)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(5)	119						CACTCCTTCTCTTTTTCCAGC	0.547000										HNSCC(40;0.11)			25	104					0	0	1	0	0
PHRF1	57661	broad.mit.edu	37	11	591423	591423	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr11:591423T>A	ENST00000264555.5	+	5	588	c.460T>A	c.(460-462)Tgc>Agc	p.C154S	PHRF1_ENST00000533464.1_Missense_Mutation_p.C150S|PHRF1_ENST00000416188.2_Missense_Mutation_p.C154S|PHRF1_ENST00000413872.2_Missense_Mutation_p.C153S	NM_020901.2	NP_065952.2	Q9P1Y6	PHRF1_HUMAN	PHD and ring finger domains 1	154							RNA polymerase binding|zinc ion binding			breast(1)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(13)|urinary_tract(2)	28						TCTATTTAAGTGCATTTGTAT	0.438000													7	9					0	0	1	0	0
HEG1	57493	broad.mit.edu	37	3	124732148	124732148	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:124732148G>A	ENST00000311127.4	-	6	2342	c.2275C>T	c.(2275-2277)Cag>Tag	p.Q759*		NM_020733.1	NP_065784.1	Q9ULI3	HEG1_HUMAN	heart development protein with EGF-like domains 1	759						extracellular region|integral to membrane	calcium ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(24)|ovary(2)|urinary_tract(4)	47						GTTGATGTCTGAAATGAAGTC	0.473000													46	155					0	0	1	0	0
GSPT2	23708	broad.mit.edu	37	X	51486866	51486866	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chrX:51486866C>T	ENST00000340438.4	+	1	386	c.144C>T	c.(142-144)ttC>ttT	p.F48F		NM_018094.4	NP_060564.2	Q8IYD1	ERF3B_HUMAN	G1 to S phase transition 2	48					cell cycle|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|translational termination	cytoplasm	GTP binding|GTPase activity|protein binding			breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	20	Ovarian(276;0.236)					GCTCGGCTTTCAGCCGTAAGC	0.697000													13	23					0	0	1	0	0
PLEKHG4B	153478	broad.mit.edu	37	5	163585	163585	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr5:163585C>T	ENST00000283426.6	+	11	2380	c.2330C>T	c.(2329-2331)cCg>cTg	p.P777L		NM_052909.3	NP_443141.3	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 4B	777					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			endometrium(1)|large_intestine(2)|lung(2)|prostate(3)|skin(3)	11			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		AGGAGCCCCCCGGTCACTCAG	0.647000													9	424					0	0	1	0	0
DLGAP3	58512	broad.mit.edu	37	1	35331745	35331745	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:35331745G>A	ENST00000373347.1	-	12	3147	c.2879C>T	c.(2878-2880)tCg>tTg	p.S960L	DLGAP3_ENST00000235180.4_Missense_Mutation_p.S960L			O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated protein 3	960					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(23)|ovary(4)|prostate(3)|skin(3)|urinary_tract(1)	46		Myeloproliferative disorder(586;0.0393)				CTCGGTGGCCGAGCTGTGGCG	0.741000													5	7					0	0	1	0	0
EXOG	9941	broad.mit.edu	37	3	38565820	38565820	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:38565820G>A	ENST00000287675.5	+	6	1170	c.1074G>A	c.(1072-1074)gaG>gaA	p.E358E	EXOG_ENST00000358249.2_Intron|EXOG_ENST00000422077.2_Silent_p.E308E	NM_005107.3	NP_005098.2	Q9Y2C4	EXOG_HUMAN	endo/exonuclease (5'-3'), endonuclease G-like	358						mitochondrial inner membrane	endonuclease activity|metal ion binding|nucleic acid binding			central_nervous_system(1)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|urinary_tract(2)	17						AAGCTAAGGAGCAGTCAGGAA	0.398000													12	31					0	0	1	0	0
KCNH7	90134	broad.mit.edu	37	2	163374268	163374268	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:163374268G>A	ENST00000332142.5	-	4	963	c.864C>T	c.(862-864)aaC>aaT	p.N288N	KCNH7_ENST00000477019.1_5'UTR|KCNH7_ENST00000328032.4_Silent_p.N288N	NM_033272.3	NP_150375.2	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 7	288					regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(22)|lung(53)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	108					Ibutilide(DB00308)	CTCTAAATATGTTCTTGGGGT	0.383000													25	54					0	0	1	0	0
RNF213	57674	broad.mit.edu	37	17	78282946	78282946	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr17:78282946G>A	ENST00000582970.1	+	14	2773	c.2630G>A	c.(2629-2631)aGa>aAa	p.R877K	RNF213_ENST00000456466.1_Missense_Mutation_p.R877K|RNF213_ENST00000508628.2_Missense_Mutation_p.R926K|RNF213_ENST00000319921.4_Missense_Mutation_p.R877K	NM_001256071.1	NP_001243000.1	Q9HCF4	ALO17_HUMAN	ring finger protein 213	877										NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	130	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			ATTGTCTGCAGAATGATTAGA	0.468000													29	78					0	0	1	0	0
NOL6	65083	broad.mit.edu	37	9	33470057	33470057	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr9:33470057A>G	ENST00000379471.2	-	4	598	c.511T>C	c.(511-513)Tgc>Cgc	p.C171R	NOL6_ENST00000455041.2_Intron|NOL6_ENST00000464829.1_5'UTR			Q9H6R4	NOL6_HUMAN	nucleolar protein 6 (RNA-associated)	171					rRNA processing	condensed nuclear chromosome|nucleolus	RNA binding			endometrium(4)|kidney(4)|large_intestine(5)|lung(8)|ovary(2)|prostate(2)|skin(2)	27			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.152)		GGTCGGATGCAGGTGCCCAGA	0.587000													37	45					0	0	1	0	0
VPREB1	7441	broad.mit.edu	37	22	22599384	22599384	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr22:22599384C>G	ENST00000403807.3	+	2	212	c.73C>G	c.(73-75)Cag>Gag	p.Q25E	VPREB1_ENST00000302273.2_Missense_Mutation_p.Q24E			P12018	VPREB_HUMAN	pre-B lymphocyte 1	25	Framework-1.|Ig-like V-type.				immune response	extracellular region	antigen binding|protein binding			large_intestine(1)|liver(1)|lung(6)|skin(1)	9	all_hematologic(9;0.0312)|Acute lymphoblastic leukemia(84;0.155)	all_cancers(3;3.14e-14)|Acute lymphoblastic leukemia(3;2.97e-57)|all_hematologic(3;5.9e-52)		READ - Rectum adenocarcinoma(21;0.145)		GGTGCTGCATCAGCCGCCGGC	0.617000													20	44					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	186056580	186056580	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:186056580C>A	ENST00000271588.4	+	60	9395	c.9166C>A	c.(9166-9168)Cca>Aca	p.P3056T	HMCN1_ENST00000367492.2_Missense_Mutation_p.P3056T	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	3056	Ig-like C2-type 29.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						CTCAGTGCCCCCAAGCATTAA	0.373000													18	56					2.35188e-11	2.49114e-11	1	1	0
ARHGAP21	57584	broad.mit.edu	37	10	24873966	24873966	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr10:24873966C>T	ENST00000396432.2	-	26	5738	c.5252G>A	c.(5251-5253)aGa>aAa	p.R1751K		NM_020824.3	NP_065875.3	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	1750	Interaction with CTNNA1.				signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(17)|lung(21)|ovary(7)|pancreas(1)|prostate(5)|skin(2)|stomach(2)|urinary_tract(1)	78						GGATTCGCCTCTGGTGGGTGT	0.448000													35	118					0	0	1	0	0
KIF1B	23095	broad.mit.edu	37	1	10335507	10335507	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:10335507G>C	ENST00000377086.1	+	11	1106	c.904G>C	c.(904-906)Gat>Cat	p.D302H	KIF1B_ENST00000263934.6_Missense_Mutation_p.D296H|KIF1B_ENST00000377093.4_Missense_Mutation_p.D296H|KIF1B_ENST00000377081.1_Missense_Mutation_p.D302H|KIF1B_ENST00000377083.1_Missense_Mutation_p.D296H			O60333	KIF1B_HUMAN	kinesin family member 1B	302	Interaction with KBP.|Kinesin-motor.				anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			breast(2)|endometrium(7)|kidney(8)|large_intestine(9)|lung(29)|ovary(3)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(2)	71	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		GAAGAAAACAGATTTTATTCC	0.313000													10	23					0	0	1	0	0
IL12A-AS1	101928376	broad.mit.edu	37	3	159819205	159819205	+	RNA	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:159819205C>G	ENST00000497452.1	-	0	517																											CAATGACTATCAGTCCATAGA	0.338000													6	62					0	0	1	0	0
DNAH12	201625	broad.mit.edu	37	3	57494894	57494894	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:57494894T>C	ENST00000351747.2	-	6	695	c.515A>G	c.(514-516)gAa>gGa	p.E172G	DNAH12_ENST00000311202.6_Missense_Mutation_p.E172G|DNAH12_ENST00000389536.4_Missense_Mutation_p.E172G	NM_178504.4	NP_848599.3	Q6ZR08	DYH12_HUMAN	dynein, axonemal, heavy chain 12	172	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(4)|lung(7)|pancreas(1)|prostate(1)|skin(1)	25						AGGACCTCCTTCATCTTCAAG	0.313000													9	35					0	0	1	0	0
RPL7	6129	broad.mit.edu	37	8	74204109	74204109	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr8:74204109C>T	ENST00000396467.1	-	4	345	c.207G>A	c.(205-207)ttG>ttA	p.L69L	RPL7_ENST00000396465.1_Silent_p.L69L|RPL7_ENST00000396466.1_Silent_p.L69L|RPL7_ENST00000352983.2_Silent_p.L109L	NM_000971.3	NP_000962.2	P18124	RL7_HUMAN	ribosomal protein L7	109					endocrine pancreas development|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	DNA binding|mRNA binding|protein homodimerization activity|structural constituent of ribosome			breast(1)|kidney(1)|large_intestine(2)|lung(1)	5	Breast(64;0.0954)		Epithelial(68;0.0193)|all cancers(69;0.0766)|BRCA - Breast invasive adenocarcinoma(89;0.134)			GAAGAAGCTGCAACACCTTTC	0.413000													30	56					0	0	1	0	0
MAGI2	9863	broad.mit.edu	37	7	77755139	77755139	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr7:77755139T>C	ENST00000354212.4	-	20	3692	c.3439A>G	c.(3439-3441)Act>Gct	p.T1147A	MAGI2_ENST00000522391.1_Missense_Mutation_p.T1147A|MAGI2_ENST00000419488.1_Missense_Mutation_p.T1133A	NM_012301.3	NP_036433.2	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 2	1147	PDZ 6.					cell junction|synapse|synaptosome	phosphatase binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(37)|ovary(5)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(3)	84		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				ATGTCCACAGTGAAATAATCA	0.403000													17	33					0	0	1	0	0
SLC10A5	347051	broad.mit.edu	37	8	82605923	82605923	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr8:82605923G>T	ENST00000518568.1	-	1	2486	c.1285C>A	c.(1285-1287)Caa>Aaa	p.Q429K		NM_001010893.2	NP_001010893.1	Q5PT55	NTCP5_HUMAN	solute carrier family 10, member 5	429						integral to membrane	bile acid:sodium symporter activity			autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(5)	15						CTTTTATCTTGTAAGAAAAAG	0.343000													5	10					0.184627	0.184819	1	1	0
ZAN	7455	broad.mit.edu	37	7	100391638	100391638	+	RNA	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr7:100391638C>G	ENST00000542585.1	+	0	8194				ZAN_ENST00000449052.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000427578.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CATCTACTACCAGGTCTGAGC	0.642000													10	16					0	0	1	0	0
ZNF416	55659	broad.mit.edu	37	19	58084192	58084192	+	Silent	SNP	T	T	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:58084192T>C	ENST00000196489.3	-	4	1302	c.1080A>G	c.(1078-1080)ggA>ggG	p.G360G		NM_017879.1	NP_060349.1	Q9BWM5	ZN416_HUMAN	zinc finger protein 416	360					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|large_intestine(5)|lung(12)|prostate(1)	22		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0259)		CAAAGGCTTTTCCACATTCAT	0.418000													53	76					0	0	1	0	0
OR10J5	127385	broad.mit.edu	37	1	159505745	159505745	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:159505745G>A	ENST00000334857.2	-	1	97	c.53C>T	c.(52-54)tCt>tTt	p.S18F		NM_001004469.1	NP_001004469.1	Q8NHC4	O10J5_HUMAN	olfactory receptor, family 10, subfamily J, member 5	18					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(4)|lung(9)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	22	all_hematologic(112;0.0429)					TCCAAAGCTAGAAAATCCCAA	0.368000													20	384					0	0	1	0	0
IMP4	92856	broad.mit.edu	37	2	131103679	131103679	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:131103679C>T	ENST00000259239.3	+	7	1391	c.683C>T	c.(682-684)tCa>tTa	p.S228L	IMP4_ENST00000409935.1_Missense_Mutation_p.S228L	NM_033416.1	NP_219484.1	Q96G21	IMP4_HUMAN	IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast)	228	Brix.				rRNA processing|translation	nucleolus|ribonucleoprotein complex	aminoacyl-tRNA ligase activity|ATP binding|protein binding			central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|skin(1)|urinary_tract(1)	18	Colorectal(110;0.1)					GACTACATATCATTCCGGTGG	0.592000													13	32					0	0	1	0	0
DGKH	160851	broad.mit.edu	37	13	42740773	42740773	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr13:42740773C>T	ENST00000261491.5	+	9	1102	c.1081C>T	c.(1081-1083)Cag>Tag	p.Q361*	DGKH_ENST00000536612.1_Nonsense_Mutation_p.Q225*|DGKH_ENST00000540693.1_Nonsense_Mutation_p.Q361*|DGKH_ENST00000498255.2_3'UTR|DGKH_ENST00000538674.1_Nonsense_Mutation_p.Q116*|DGKH_ENST00000337343.4_Nonsense_Mutation_p.Q361*|DGKH_ENST00000379274.2_Nonsense_Mutation_p.Q225*	NM_152910.4	NP_690874.2	Q86XP1	DGKH_HUMAN	diacylglycerol kinase, eta		DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation|protein oligomerization	endosome|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			breast(2)|endometrium(3)|kidney(5)|large_intestine(11)|lung(9)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43		Lung NSC(96;1.02e-05)|Prostate(109;0.0168)|Lung SC(185;0.0262)|Breast(139;0.0709)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;5.88e-05)|GBM - Glioblastoma multiforme(144;0.000935)|BRCA - Breast invasive adenocarcinoma(63;0.109)		AAATCCGGCTCAGGTGTTTGA	0.368000													13	21					0	0	1	0	0
POU5F1B	5462	broad.mit.edu	37	8	128428768	128428768	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr8:128428768G>C	ENST00000465342.2	+	2	1814	c.657G>C	c.(655-657)gaG>gaC	p.E219D	CASC8_ENST00000501396.1_RNA|CASC8_ENST00000502082.1_RNA|POU5F1B_ENST00000391675.1_Missense_Mutation_p.E219D|CASC8_ENST00000523825.1_RNA			Q06416	P5F1B_HUMAN	POU class 5 homeobox 1B	219						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			lung(1)|prostate(1)|urinary_tract(1)	3						ATCTTCAGGAGATATGCAAAG	0.507000													3	42					0	0	1	0	0
FCRL3	115352	broad.mit.edu	37	1	157660181	157660181	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:157660181C>T	ENST00000368184.3	-	9	1845	c.1554G>A	c.(1552-1554)ggG>ggA	p.G518G	FCRL3_ENST00000473231.1_5'UTR|FCRL3_ENST00000368186.5_Silent_p.G518G	NM_052939.3	NP_443171.2	Q96P31	FCRL3_HUMAN	Fc receptor-like 3	518	Ig-like C2-type 6.					integral to membrane|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(1)|large_intestine(13)|lung(31)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)	69	all_hematologic(112;0.0378)					CCGAGATGTTCCCCAAGGTGT	0.567000													27	122					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92087888	92087888	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr11:92087888C>T	ENST00000298047.6	+	1	2627	c.2610C>T	c.(2608-2610)gtC>gtT	p.V870V	FAT3_ENST00000409404.2_Silent_p.V870V|FAT3_ENST00000541502.1_Silent_p.V870V|FAT3_ENST00000525166.1_Silent_p.V720V			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	870	Cadherin 8.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CTTACTCAGTCTTGACAGATA	0.408000										TCGA Ovarian(4;0.039)			22	32					0	0	1	0	0
PPIL4	85313	broad.mit.edu	37	6	149867084	149867084	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr6:149867084C>T	ENST00000253329.2	-	1	90	c.58G>A	c.(58-60)Gaa>Aaa	p.E20K		NM_139126.3	NP_624311.1	Q8WUA2	PPIL4_HUMAN	peptidylprolyl isomerase (cyclophilin)-like 4	20	PPIase cyclophilin-type.				protein folding	nucleus	nucleotide binding|peptidyl-prolyl cis-trans isomerase activity|RNA binding			endometrium(2)|kidney(4)|large_intestine(1)|lung(4)|prostate(1)|urinary_tract(1)	13		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.11e-11)|GBM - Glioblastoma multiforme(68;0.0885)		CGCGGCCGTTCTTCGGTGTAC	0.642000													6	19					0	0	1	0	0
TXLNA	200081	broad.mit.edu	37	1	32650157	32650157	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:32650157G>C	ENST00000373609.1	+	3	818	c.537G>C	c.(535-537)ttG>ttC	p.L179F	TXLNA_ENST00000373610.3_Missense_Mutation_p.L179F			P40222	TXLNA_HUMAN	taxilin alpha	179					cell proliferation|exocytosis	cytoplasm|extracellular region	cytokine activity|high molecular weight B cell growth factor receptor binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(2)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	13		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				TGCAGACATTGAATACTCTGA	0.567000													39	89					0	0	1	0	0
DNM1P46	196968	broad.mit.edu	37	15	100332113	100332113	+	RNA	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr15:100332113C>T	ENST00000341853.1	-	0	2078					NR_003260.1																						TTGCATTTTTCAACTCCGCTG	0.592000													15	27					0	0	1	0	0
ADAM17	6868	broad.mit.edu	37	2	9642320	9642320	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:9642320C>A	ENST00000310823.3	-	13	1812	c.1630G>T	c.(1630-1632)Ggc>Tgc	p.G544C		NM_003183.4	NP_003174.3	P78536	ADA17_HUMAN	ADAM metallopeptidase domain 17	544	Disintegrin.				B cell differentiation|cell adhesion mediated by integrin|epidermal growth factor receptor signaling pathway|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|germinal center formation|membrane protein intracellular domain proteolysis|negative regulation of interleukin-8 production|nerve growth factor receptor signaling pathway|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of chemokine production|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of protein phosphorylation|positive regulation of T cell chemotaxis|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of mast cell apoptosis|response to drug|response to high density lipoprotein particle stimulus|response to hypoxia|response to lipopolysaccharide|spleen development|T cell differentiation in thymus|wound healing, spreading of epidermal cells	actin cytoskeleton|apical plasma membrane|cell surface|cytoplasm|integral to plasma membrane|membrane raft	integrin binding|interleukin-6 receptor binding|metalloendopeptidase activity|PDZ domain binding|SH3 domain binding|zinc ion binding			breast(1)|cervix(4)|endometrium(2)|kidney(2)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(1)	28	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.225)		TAGGACACGCCTTTGCAAGTA	0.458000													6	240					0.217242	0.217242	1	1	0
WDR66	144406	broad.mit.edu	37	12	122359356	122359356	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr12:122359356G>A	ENST00000288912.4	+	2	999	c.145G>A	c.(145-147)Gag>Aag	p.E49K	WDR66_ENST00000397454.2_Missense_Mutation_p.E49K|RP11-87C12.2_ENST00000546333.1_3'UTR	NM_144668.5	NP_653269.3	Q8TBY9	WDR66_HUMAN	WD repeat domain 66	49	Glu-rich.						calcium ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(13)|ovary(2)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	all_neural(191;0.0496)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000155)|Epithelial(86;0.000634)|BRCA - Breast invasive adenocarcinoma(302;0.248)		AGCATGGAGAGAGTCTCagga	0.453000													24	25					0	0	1	0	0
GOLGA4	2803	broad.mit.edu	37	3	37367249	37367249	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:37367249C>A	ENST00000361924.2	+	14	4246	c.3872C>A	c.(3871-3873)tCt>tAt	p.S1291Y	GOLGA4_ENST00000356847.4_Missense_Mutation_p.S1313Y|GOLGA4_ENST00000444882.1_Intron	NM_002078.4	NP_002069.2	Q13439	GOGA4_HUMAN	golgin A4	1291	Glu-rich.				Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding			NS(2)|breast(3)|central_nervous_system(3)|endometrium(6)|kidney(2)|large_intestine(17)|liver(2)|lung(16)|ovary(4)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	65						CTAAATATTTCTTTTCAACAG	0.333000													13	27					0.00136819	0.00138977	1	1	0
SRRT	51593	broad.mit.edu	37	7	100481999	100481999	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr7:100481999G>C	ENST00000388793.4	+	7	988	c.768G>C	c.(766-768)aaG>aaC	p.K256N	SRRT_ENST00000432932.1_Missense_Mutation_p.K256N|SRRT_ENST00000457580.2_Missense_Mutation_p.K256N|SRRT_ENST00000347433.4_Missense_Mutation_p.K256N	NM_001128852.1|NM_015908.5	NP_001122324.1|NP_056992.4	Q9BXP5	SRRT_HUMAN	serrate RNA effector molecule homolog (Arabidopsis)	256					cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			breast(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(5)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40						CCGTGATTAAGATGGAAGGAG	0.587000													3	17					0	0	1	0	0
DTL	51514	broad.mit.edu	37	1	212236235	212236235	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:212236235G>T	ENST00000366991.4	+	6	784	c.470G>T	c.(469-471)tGt>tTt	p.C157F	DTL_ENST00000542077.1_Missense_Mutation_p.C115F|DTL_ENST00000475419.1_3'UTR	NM_016448.2	NP_057532.2	Q9NZJ0	DTL_HUMAN	denticleless E3 ubiquitin protein ligase homolog (Drosophila)	157					DNA replication|G2/M transition DNA damage checkpoint|protein monoubiquitination|protein polyubiquitination|response to UV|translesion synthesis|ubiquitin-dependent protein catabolic process	centrosome|Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|nuclear membrane	protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|lung(6)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(81;0.00796)|all cancers(67;0.0385)|Epithelial(68;0.102)		GCTGTATTCTGTACGGGTGGA	0.348000													10	47					1.58986e-06	1.65675e-06	1	1	0
TNFAIP6	7130	broad.mit.edu	37	2	152235955	152235955	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:152235955G>C	ENST00000243347.3	+	6	817	c.742G>C	c.(742-744)Gat>Cat	p.D248H		NM_007115.3	NP_009046.2	P98066	TSG6_HUMAN	tumor necrosis factor, alpha-induced protein 6	248					cell adhesion|cell-cell signaling|inflammatory response|signal transduction		hyaluronic acid binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.131)		TGTTGCAATGGATCCTGTATC	0.363000													26	69					0	0	1	0	0
FKRP	79147	broad.mit.edu	37	19	47259873	47259873	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:47259873A>G	ENST00000318584.5	+	4	1463	c.1166A>G	c.(1165-1167)gAg>gGg	p.E389G	FKRP_ENST00000391909.3_Missense_Mutation_p.E389G|FKRP_ENST00000600646.1_Intron	NM_001039885.2|NM_024301.4	NP_001034974.1|NP_077277.1	Q9H9S5	FKRP_HUMAN	fukutin related protein	389						extracellular space|Golgi apparatus|rough endoplasmic reticulum|sarcolemma	transferase activity			NS(1)|large_intestine(1)|lung(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	7		all_epithelial(76;5.08e-05)|Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000541)|all cancers(93;0.00128)|Epithelial(262;0.0207)|GBM - Glioblastoma multiforme(486;0.0336)		GTGGTGGATGAGCGCGGCTTC	0.632000													5	12					0	0	1	0	0
DHX15	1665	broad.mit.edu	37	4	24534618	24534618	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr4:24534618C>T	ENST00000336812.4	-	12	2125	c.1969G>A	c.(1969-1971)Gca>Aca	p.A657T	DHX15_ENST00000508032.1_5'UTR	NM_001358.2	NP_001349.2	O43143	DHX15_HUMAN	DEAH (Asp-Glu-Ala-His) box helicase 15	657					mRNA processing	U12-type spliceosomal complex	ATP binding|ATP-dependent helicase activity|nucleic acid binding|RNA helicase activity			breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	30		Breast(46;0.0503)				ACATTGTCTGCGGACATCAGG	0.413000													4	171					0	0	1	0	0
CBLL1	79872	broad.mit.edu	37	7	107399329	107399329	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr7:107399329G>A	ENST00000440859.3	+	6	1649	c.1182G>A	c.(1180-1182)caG>caA	p.Q394Q	CBLL1_ENST00000222597.2_Silent_p.Q393Q	NM_001284291.1|NM_024814.2	NP_001271220.1|NP_079090.2	Q75N03	HAKAI_HUMAN	Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase		Pro-rich.				cell-cell adhesion|negative regulation of cell adhesion|positive regulation of cell migration|positive regulation of endocytosis		protein binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|large_intestine(2)|lung(9)|ovary(2)|prostate(3)|skin(3)	21						TTATTGCCCAGATGCCACCTT	0.522000													49	117					0	0	1	0	0
REL	5966	broad.mit.edu	37	2	61149307	61149307	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:61149307G>A	ENST00000295025.8	+	11	1817	c.1497G>A	c.(1495-1497)atG>atA	p.M499I	REL_ENST00000394479.3_Missense_Mutation_p.M467I	NM_002908.2	NP_002899.1	Q04864	REL_HUMAN	v-rel avian reticuloendotheliosis viral oncogene homolog						positive regulation of I-kappaB kinase/NF-kappaB cascade	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|large_intestine(5)|lung(3)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	16	all_hematologic(2;0.0797)	Ovarian(717;0.0728)	LUSC - Lung squamous cell carcinoma(5;6.2e-08)|Lung(5;1.65e-06)|Epithelial(17;0.064)|all cancers(80;0.221)			TGAATATGATGACAACCAGCA	0.428000			A		Hodgkin Lymphoma								24	62					0	0	1	0	0
CYFIP2	26999	broad.mit.edu	37	5	156727863	156727863	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr5:156727863C>A	ENST00000347377.6	+	6	959	c.528C>A	c.(526-528)aaC>aaA	p.N176K	CYFIP2_ENST00000442283.2_De_novo_Start_InFrame|CYFIP2_ENST00000521420.1_Missense_Mutation_p.N150K|CYFIP2_ENST00000541131.1_Missense_Mutation_p.N101K|CYFIP2_ENST00000377576.3_Missense_Mutation_p.N176K|CYFIP2_ENST00000522463.1_Intron|CYFIP2_ENST00000318218.6_Missense_Mutation_p.N176K	NM_001037332.2	NP_001032409.2	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	176					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding			breast(1)|endometrium(12)|kidney(2)|lung(23)	38	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AGCTAAAGAACATGAAGTGCA	0.567000													8	26					0.00307968	0.00311842	1	1	0
CNKSR2	22866	broad.mit.edu	37	X	21393072	21393072	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chrX:21393072G>A	ENST00000425654.2	+	1	537	c.57G>A	c.(55-57)tgG>tgA	p.W19*	CNKSR2_ENST00000543067.1_Nonsense_Mutation_p.W19*|CNKSR2_ENST00000379510.3_Nonsense_Mutation_p.W19*|CNKSR2_ENST00000279451.4_Nonsense_Mutation_p.W19*	NM_001168647.1	NP_001162118.1	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras 2	19	SAM.				regulation of signal transduction	cytoplasm|membrane	protein binding			breast(3)|endometrium(8)|kidney(2)|large_intestine(15)|lung(28)|prostate(2)|upper_aerodigestive_tract(3)	61						TAGTGGACTGGATGAAAGGTA	0.652000													20	24					0	0	1	0	0
UBE2H	7328	broad.mit.edu	37	7	129474824	129474824	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr7:129474824A>C	ENST00000355621.3	-	7	898	c.505T>G	c.(505-507)Tct>Gct	p.S169A	UBE2H_ENST00000473814.2_Missense_Mutation_p.S138A	NM_001202498.1|NM_003344.3	NP_001189427.1|NP_003335.1	P62256	UBE2H_HUMAN	ubiquitin-conjugating enzyme E2H	169					protein K11-linked ubiquitination|protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process		ATP binding|ubiquitin-protein ligase activity			cervix(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(2)|skin(1)	10	Melanoma(18;0.0435)					TCAGACATAGAGCTCTCCGAT	0.493000													31	55					0	0	1	0	0
PBX3	5090	broad.mit.edu	37	9	128697770	128697770	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr9:128697770A>G	ENST00000373487.4	+	5	807	c.727A>G	c.(727-729)Agt>Ggt	p.S243G	PBX3_ENST00000373489.5_Missense_Mutation_p.S243G|PBX3_ENST00000447726.2_Missense_Mutation_p.S168G|PBX3_ENST00000342287.5_Missense_Mutation_p.S243G|PBX3_ENST00000538998.1_3'UTR|PBX3_ENST00000373483.2_Missense_Mutation_p.S62G			P40426	PBX3_HUMAN	pre-B-cell leukemia homeobox 3	243					anterior compartment pattern formation|posterior compartment specification		sequence-specific DNA binding transcription factor activity			biliary_tract(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|skin(1)|upper_aerodigestive_tract(2)	24						GCGTAACTTCAGTAAACAGGC	0.413000													18	42					0	0	1	0	0
TRMT2A	27037	broad.mit.edu	37	22	20103693	20103693	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr22:20103693C>T	ENST00000252136.7	-	2	855	c.467G>A	c.(466-468)cGa>cAa	p.R156Q	TRMT2A_ENST00000403707.3_Missense_Mutation_p.R156Q|RANBP1_ENST00000430524.1_5'UTR|TRMT2A_ENST00000404751.3_Missense_Mutation_p.R156Q|TRMT2A_ENST00000439169.2_Missense_Mutation_p.R156Q	NM_001257994.1|NM_022727.5|NM_182984.4	NP_001244923.1|NP_073564.3|NP_892029.2	Q8IZ69	TRM2A_HUMAN	tRNA methyltransferase 2 homolog A (S. cerevisiae)	156	Poly-Arg.				RNA processing		nucleotide binding|RNA binding|RNA methyltransferase activity			breast(2)|endometrium(2)|lung(5)	9						ACCCTCCTGTCGCCTCCTCCT	0.652000													13	34					0	0	1	0	0
RWDD1	51389	broad.mit.edu	37	6	116911482	116911482	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr6:116911482G>A	ENST00000466444.2	+	5	678	c.462G>A	c.(460-462)tgG>tgA	p.W154*	RWDD1_ENST00000487832.2_Nonsense_Mutation_p.W58*|RWDD1_ENST00000392526.1_Nonsense_Mutation_p.W58*	NM_015952.2	NP_057036.2	Q9H446	RWDD1_HUMAN	RWD domain containing 1	154	Interaction with DRG2 (By similarity).						protein binding	p.W154*(1)		NS(1)|breast(2)|central_nervous_system(1)|large_intestine(3)|lung(1)|ovary(2)|prostate(1)|skin(1)	12		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.026)|all cancers(137;0.0312)|OV - Ovarian serous cystadenocarcinoma(136;0.0689)|Epithelial(106;0.161)		TCTTAAATTGGAAAGCCAAGT	0.308000													6	40					0	0	1	0	0
PAX7	5081	broad.mit.edu	37	1	19062210	19062210	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:19062210G>A	ENST00000420770.2	+	8	1323	c.1240G>A	c.(1240-1242)Gac>Aac	p.D414N	PAX7_ENST00000400661.3_Missense_Mutation_p.D412N|PAX7_ENST00000375375.3_Missense_Mutation_p.D414N	NM_001135254.1	NP_001128726.1	P23759	PAX7_HUMAN	paired box 7	414					anti-apoptosis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX7/FOXO1(197)	breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(17)|ovary(1)|prostate(1)|skin(2)	31		Colorectal(325;3.46e-05)|all_lung(284;0.000439)|Renal(390;0.000518)|Lung NSC(340;0.000543)|Breast(348;0.00093)|Ovarian(437;0.00768)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00609)|BRCA - Breast invasive adenocarcinoma(304;4.71e-05)|Kidney(64;0.000279)|KIRC - Kidney renal clear cell carcinoma(64;0.00371)|STAD - Stomach adenocarcinoma(196;0.00658)|READ - Rectum adenocarcinoma(331;0.0576)		TGGCGGCCTGGACTCGGCCAC	0.667000			T	FOXO1A	alveolar rhabdomyosarcoma								20	56					0	0	1	0	0
PIK3CB	5291	broad.mit.edu	37	3	138376657	138376657	+	Silent	SNP	T	T	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:138376657T>C	ENST00000477593.1	-	21	2890	c.2817A>G	c.(2815-2817)ggA>ggG	p.G939G	PIK3CB_ENST00000289153.2_Silent_p.G939G|PIK3CB_ENST00000544716.1_Silent_p.G390G			P42338	PK3CB_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	939	PI3K/PI4K.				activation of MAPK activity|chemotaxis|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			NS(1)|breast(3)|endometrium(5)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(4)	41						CAAGAATATGTCCAAAGTCAA	0.353000													20	26					0	0	1	0	0
RNF40	9810	broad.mit.edu	37	16	30785347	30785347	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr16:30785347G>T	ENST00000324685.6	+	20	3353	c.2918G>T	c.(2917-2919)cGg>cTg	p.R973L	RNF40_ENST00000563683.1_Missense_Mutation_p.R933L|RNF40_ENST00000357890.5_Missense_Mutation_p.R873L|RNF40_ENST00000402121.3_Missense_Mutation_p.R665L	NM_001207033.1|NM_014771.3	NP_001193962.1|NP_055586	O75150	BRE1B_HUMAN	ring finger protein 40, E3 ubiquitin protein ligase	973					histone H2B ubiquitination|histone monoubiquitination|ubiquitin-dependent protein catabolic process	nucleus|synaptosome|ubiquitin ligase complex	protein homodimerization activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(10)|prostate(2)	30			Colorectal(24;0.198)			GAGTGCGTGCGGGGCCGCTAT	0.597000													7	166					0.00198382	0.00201088	1	1	0
OR1L3	26735	broad.mit.edu	37	9	125437411	125437411	+	Translation_Start_Site	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr9:125437411G>C	ENST00000304820.2	+	1	97	c.3G>C	c.(1-3)atG>atC	p.M1I		NM_001005234.1	NP_001005234.1	Q8NH93	OR1L3_HUMAN	olfactory receptor, family 1, subfamily L, member 3	1					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(1)|large_intestine(2)|lung(6)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	16						ACAAGTCCATGGGAATGTCCA	0.408000													20	78					0	0	1	0	0
CCDC14	64770	broad.mit.edu	37	3	123650067	123650067	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:123650067G>C	ENST00000485727.1	-	8	5796	c.1204C>G	c.(1204-1206)Cta>Gta	p.L402V	CCDC14_ENST00000433542.2_Missense_Mutation_p.L561V|CCDC14_ENST00000488653.2_Missense_Mutation_p.L602V|CCDC14_ENST00000489746.1_Missense_Mutation_p.L402V|CCDC14_ENST00000310351.4_Missense_Mutation_p.L442V|CCDC14_ENST00000483247.1_Intron			Q49A88	CCD14_HUMAN	coiled-coil domain containing 14	602						centrosome				NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(10)	21		Lung NSC(201;0.0371)|Prostate(884;0.0405)|Myeloproliferative disorder(1037;0.205)		Lung(219;0.00942)|GBM - Glioblastoma multiforme(114;0.159)		ACATTGACTAGGGCTTCCTCC	0.368000													7	16					0	0	1	0	0
HFM1	164045	broad.mit.edu	37	1	91818146	91818146	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:91818146T>C	ENST00000370425.3	-	16	1992	c.1894A>G	c.(1894-1896)Aca>Gca	p.T632A	HFM1_ENST00000370424.3_Missense_Mutation_p.T311A|HFM1_ENST00000462405.1_5'UTR|HFM1_ENST00000294696.5_5'UTR	NM_001017975.3	NP_001017975.3	A2PYH4	HFM1_HUMAN	HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)	632	Helicase C-terminal.						ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(33)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	75		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		TAATGCATTGTAGATTTTATA	0.368000													19	24					0	0	1	0	0
CCDC88C	440193	broad.mit.edu	37	14	91780000	91780000	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr14:91780000G>A	ENST00000389857.6	-	15	2246	c.2160C>T	c.(2158-2160)agC>agT	p.S720S		NM_001080414.3	NP_001073883.2	Q9P219	DAPLE_HUMAN	coiled-coil domain containing 88C	720					microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(6)|pancreas(1)|urinary_tract(1)	24		all_cancers(154;0.0468)				CCAGCTTGGTGCTGGTGAAGC	0.607000													16	51					0	0	1	0	0
PHACTR4	65979	broad.mit.edu	37	1	28807075	28807075	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:28807075G>T	ENST00000373839.3	+	9	1980	c.1719G>T	c.(1717-1719)gaG>gaT	p.E573D	PHACTR4_ENST00000493669.1_3'UTR|PHACTR4_ENST00000373836.3_Missense_Mutation_p.E583D	NM_001048183.1	NP_001041648.1	Q8IZ21	PHAR4_HUMAN	phosphatase and actin regulator 4	573							actin binding|protein phosphatase inhibitor activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(6)|lung(10)|ovary(3)|skin(1)|urinary_tract(1)	32		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;7.01e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;1.35e-21)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0144)|READ - Rectum adenocarcinoma(331;0.0649)		GCAAGGAGGAGTGGAATGAAA	0.433000													36	99					9.21846e-06	9.55476e-06	1	1	0
BIRC3	330	broad.mit.edu	37	11	102195711	102195711	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr11:102195711G>C	ENST00000263464.3	+	2	3221	c.471G>C	c.(469-471)ttG>ttC	p.L157F	BIRC3_ENST00000532808.1_Missense_Mutation_p.L157F	NM_001165.4	NP_001156.1	Q13489	BIRC3_HUMAN	baculoviral IAP repeat containing 3	157					anti-apoptosis|apoptosis|cell surface receptor linked signaling pathway	cytoplasm|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(7)|lung(5)|ovary(3)|skin(1)	21	all_cancers(8;0.00044)|all_epithelial(12;0.00348)|Lung NSC(15;0.227)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0093)	Lung(13;0.109)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0146)		TTTCTGCCTTGATGAGAAGTT	0.408000			T	MALT1	MALT								36	79					0	0	1	0	0
ITGAD	3681	broad.mit.edu	37	16	31419225	31419225	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr16:31419225T>C	ENST00000389202.2	+	9	1046	c.997T>C	c.(997-999)Tat>Cat	p.Y333H		NM_005353.2	NP_005344.2	Q13349	ITAD_HUMAN	integrin, alpha D	333					cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(43)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						GGAGAAGATCTATGCAGTTGA	0.547000													29	76					0	0	1	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102496233	102496233	+	Silent	SNP	G	G	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr14:102496233G>T	ENST00000360184.4	+	50	9884	c.9720G>T	c.(9718-9720)ctG>ctT	p.L3240L		NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	3240	Stalk (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						ATGACAAGCTGAAAAAGATGG	0.473000													33	21					1.30988e-24	1.41537e-24	1	1	0
BCL6	604	broad.mit.edu	37	3	187446846	187446846	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:187446846G>A	ENST00000406870.2	-	5	1713	c.1347C>T	c.(1345-1347)atC>atT	p.I449I	RP11-211G3.3_ENST00000437407.1_Intron|RP11-211G3.3_ENST00000449623.1_Intron|BCL6_ENST00000232014.4_Silent_p.I449I|BCL6_ENST00000450123.2_Silent_p.I449I	NM_001706.4	NP_001697.2	P41182	BCL6_HUMAN	B-cell CLL/lymphoma 6	449					negative regulation of B cell apoptosis|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|protein import into nucleus, translocation|regulation of germinal center formation|response to DNA damage stimulus	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(9)|lung(10)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	40	all_cancers(143;9.45e-12)|Ovarian(172;0.0418)		OV - Ovarian serous cystadenocarcinoma(80;1.76e-18)	GBM - Glioblastoma multiforme(93;0.0141)		ACCTGTTAACGATGTTATTGA	0.552000			"""T, Mis"""	"""IG loci, ZNFN1A1, LCP1, PIM1, TFRC, CIITA, NACA, HSPCB, HSPCA, HIST1H4I, IL21R,  POU2AF1, ARHH, EIF4A2, SFRS3"""	"""NHL, CLL"""								14	50					0	0	1	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54925978	54925978	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr12:54925978C>T	ENST00000293373.6	+	26	2885	c.2806C>T	c.(2806-2808)Ctt>Ttt	p.L936F	NCKAP1L_ENST00000545638.2_Missense_Mutation_p.L886F	NM_005337.4	NP_005328.2	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	936					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(37)|ovary(3)|prostate(3)|skin(3)|stomach(2)	80						CTGCCCATTTCTTATGGGTCC	0.403000													19	18					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	71127744	71127744	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr16:71127744G>A	ENST00000393567.2	-	11	1572	c.1422C>T	c.(1420-1422)ttC>ttT	p.F474F	HYDIN_ENST00000448089.2_Silent_p.F474F|HYDIN_ENST00000321489.5_Silent_p.F474F|HYDIN_ENST00000538248.1_Silent_p.F501F|HYDIN_ENST00000448691.1_Silent_p.F474F|HYDIN_ENST00000393550.2_Silent_p.F474F|HYDIN_ENST00000541601.1_Silent_p.F491F|HYDIN_ENST00000288168.10_Silent_p.F491F	NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	474										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				CAGATCCAGTGAAAACTTTCC	0.408000													12	22					0	0	1	0	0
CASQ1	844	broad.mit.edu	37	1	160168476	160168476	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:160168476A>G	ENST00000368079.3	+	8	1095	c.820A>G	c.(820-822)Atg>Gtg	p.M274V	CASQ1_ENST00000368078.3_Missense_Mutation_p.M280V|CASQ1_ENST00000467691.1_Start_Codon_SNP_p.M1V	NM_001231.4	NP_001222.3	P31415	CASQ1_HUMAN	calsequestrin 1 (fast-twitch, skeletal muscle)	280						mitochondrial matrix|sarcoplasmic reticulum lumen|smooth endoplasmic reticulum	calcium ion binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|skin(1)	21	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GGAGGATGATATGGATGGAAT	0.532000													289	47					0	0	1	0	0
BMP1	649	broad.mit.edu	37	8	22069113	22069113	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr8:22069113G>A	ENST00000306385.5	+	20	3503	c.2833G>A	c.(2833-2835)Gag>Aag	p.E945K	BMP1_ENST00000354870.5_3'UTR	NM_006129.4	NP_006120.1	P13497	BMP1_HUMAN	bone morphogenetic protein 1	945	CUB 5.				cartilage condensation|cell differentiation|lipid metabolic process|lipoprotein metabolic process|ossification|positive regulation of cartilage development|proteolysis	extracellular space	calcium ion binding|cytokine activity|growth factor activity|metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(7)|ovary(2)|prostate(1)|skin(3)	30				Colorectal(74;0.00229)|COAD - Colon adenocarcinoma(73;0.0661)|READ - Rectum adenocarcinoma(644;0.11)		CCAGCCTCCTGAGGAGGTGTA	0.572000													29	38					0	0	1	0	0
SLITRK3	22865	broad.mit.edu	37	3	164907884	164907884	+	Silent	SNP	A	A	G	rs140320748	byFrequency	TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:164907884A>G	ENST00000475390.1	-	2	1178	c.735T>C	c.(733-735)agT>agC	p.S245S	SLITRK3_ENST00000241274.3_Silent_p.S245S			O94933	SLIK3_HUMAN	SLIT and NTRK-like family, member 3	245	LRRCT 1.					integral to membrane				NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(66)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(5)	119						GTTCCAGCCAACTCTTCAGTT	0.478000										HNSCC(40;0.11)			46	55					0	0	1	0	0
GAS6	2621	broad.mit.edu	37	13	114523944	114523944	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr13:114523944T>C	ENST00000357389.3	-	15	2211	c.2059A>G	c.(2059-2061)Atg>Gtg	p.M687V	GAS6_ENST00000327773.6_Missense_Mutation_p.M644V|GAS6-AS1_ENST00000458001.1_RNA|GAS6_ENST00000418959.3_Missense_Mutation_p.M345V|GAS6_ENST00000355761.4_Missense_Mutation_p.M590V|GAS6_ENST00000450766.1_Missense_Mutation_p.M371V			Q14393	GAS6_HUMAN	growth arrest-specific 6	687	Laminin G-like 2.				cell proliferation|leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|positive regulation of ERK1 and ERK2 cascade|positive regulation of fibroblast proliferation|post-translational protein modification|proteolysis|regulation of growth	endoplasmic reticulum lumen|extracellular space|Golgi lumen|platelet alpha granule lumen	calcium ion binding|receptor agonist activity			central_nervous_system(4)|ovary(1)	5	Lung NSC(43;0.00976)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0176)|all_epithelial(44;0.0104)|all_lung(25;0.0249)|Lung NSC(25;0.0908)|Breast(118;0.188)				TCCAGTGTCATGCAGCCGCGG	0.672000													15	19					0	0	1	0	0
ZBTB47	92999	broad.mit.edu	37	3	42705397	42705397	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:42705397A>G	ENST00000457842.3	+	5	2127	c.718A>G	c.(718-720)Aag>Gag	p.K240E	ZBTB47_ENST00000505904.1_Missense_Mutation_p.K162E|ZBTB47_ENST00000232974.6_Missense_Mutation_p.K616E	NM_145166.3	NP_660149.2	Q9UFB7	ZBT47_HUMAN	zinc finger and BTB domain containing 47	240					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|large_intestine(2)|lung(3)|ovary(1)	13				KIRC - Kidney renal clear cell carcinoma(284;0.216)		CTTCAACATGAAGCAGTACTT	0.597000													5	27					0	0	1	0	0
USP53	54532	broad.mit.edu	37	4	120213550	120213550	+	Silent	SNP	C	C	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr4:120213550C>A	ENST00000450251.1	+	15	2950	c.2406C>A	c.(2404-2406)ccC>ccA	p.P802P	USP53_ENST00000274030.6_Silent_p.P802P			Q70EK8	UBP53_HUMAN	ubiquitin specific peptidase 53	802					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(5)|ovary(1)|pancreas(1)|skin(2)|stomach(1)	27						TACAAATACCCAAGGACCATA	0.338000													8	17					0.000442599	0.000451003	1	1	0
RBM23	55147	broad.mit.edu	37	14	23371437	23371437	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr14:23371437G>A	ENST00000359890.3	-	11	1280	c.1085C>T	c.(1084-1086)tCa>tTa	p.S362L	RBM23_ENST00000346528.5_Missense_Mutation_p.S328L|RBM23_ENST00000399922.2_Missense_Mutation_p.S346L|RBM23_ENST00000542016.2_Missense_Mutation_p.S192L|RBM23_ENST00000555209.1_Missense_Mutation_p.S112L	NM_001077351.1	NP_001070819.1	Q86U06	RBM23_HUMAN	RNA binding motif protein 23	362					mRNA processing	nucleus	nucleotide binding|RNA binding			endometrium(3)|kidney(2)|lung(3)|prostate(1)|skin(1)	10	all_cancers(95;4.69e-05)			GBM - Glioblastoma multiforme(265;0.0128)		TCCACCTGCTGATCCCAGATC	0.512000													31	27					0	0	1	0	0
ZNF212	7988	broad.mit.edu	37	7	148951299	148951299	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr7:148951299C>T	ENST00000335870.2	+	5	1409	c.1281C>T	c.(1279-1281)ctC>ctT	p.L427L		NM_012256.3	NP_036388.2	Q9UDV6	ZN212_HUMAN	zinc finger protein 212	427					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|identical protein binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(4)|ovary(1)|prostate(1)	9	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)			GGAGTTCCCTCATCTGTGGTT	0.612000													7	22					0	0	1	0	0
NPY1R	4886	broad.mit.edu	37	4	164247254	164247254	+	Silent	SNP	A	A	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr4:164247254A>G	ENST00000296533.2	-	2	984	c.453T>C	c.(451-453)aaT>aaC	p.N151N	NPY1R_ENST00000509586.1_Intron	NM_000909.5	NP_000900.1	P25929	NPY1R_HUMAN	neuropeptide Y receptor Y1	151					inhibition of adenylate cyclase activity by G-protein signaling pathway|outflow tract morphogenesis	integral to plasma membrane	protein binding			breast(1)|cervix(1)|large_intestine(4)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(4)	30	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				CATGTCTATTATTTGGTCTCC	0.443000													19	33					0	0	1	0	0
CCDC151	115948	broad.mit.edu	37	19	11531535	11531535	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:11531535G>C	ENST00000356392.4	-	13	1843	c.1756C>G	c.(1756-1758)Cac>Gac	p.H586D	CCDC151_ENST00000591179.1_Missense_Mutation_p.H526D|CCDC151_ENST00000545100.1_Missense_Mutation_p.H532D|CCDC151_ENST00000586836.1_Missense_Mutation_p.H395D	NM_145045.4	NP_659482.3	A5D8V7	CC151_HUMAN	coiled-coil domain containing 151	586										endometrium(2)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)	12						TGCTTCTTGTGACTTTCGATT	0.617000													18	59					0	0	1	0	0
TOPBP1	11073	broad.mit.edu	37	3	133374180	133374180	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:133374180T>A	ENST00000260810.5	-	6	827	c.696A>T	c.(694-696)caA>caT	p.Q232H	TOPBP1_ENST00000511439.1_5'UTR	NM_007027.3	NP_008958.2	Q92547	TOPB1_HUMAN	topoisomerase (DNA) II binding protein 1	232	BRCT 2.				DNA repair|response to ionizing radiation	microtubule organizing center|PML body|spindle pole	DNA binding|protein C-terminus binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(5)|lung(14)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	40						TCATTTTCAATTGTCCCATGT	0.363000								Other conserved DNA damage response genes					29	51					0	0	1	0	0
ARID1B	57492	broad.mit.edu	37	6	157525063	157525063	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr6:157525063G>A	ENST00000346085.5	+	19	4959	c.4958G>A	c.(4957-4959)tGg>tAg	p.W1653*	ARID1B_ENST00000350026.5_Nonsense_Mutation_p.W1640*|ARID1B_ENST00000275248.4_Nonsense_Mutation_p.W1635*|ARID1B_ENST00000367148.1_Nonsense_Mutation_p.W1693*	NM_020732.3	NP_065783.3	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	1640					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity	p.W1653L(1)|p.W1635L(1)		NS(2)|breast(5)|central_nervous_system(4)|endometrium(12)|kidney(4)|large_intestine(11)|lung(30)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(3)	81		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		GAGAGTACGTGGGCTTTGGAC	0.433000													149	182					0	0	1	0	0
QRICH2	84074	broad.mit.edu	37	17	74288282	74288282	+	Silent	SNP	G	G	T	rs140848920		TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr17:74288282G>T	ENST00000262765.5	-	4	2207	c.2028C>A	c.(2026-2028)gtC>gtA	p.V676V		NM_032134.1	NP_115510.1	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	676	Gln-rich.						protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(2)|stomach(4)	62						caccaggttggaccaaaccac	0.557000													27	87					5.61819e-17	6.0369e-17	1	1	0
PHIP	55023	broad.mit.edu	37	6	79711637	79711637	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr6:79711637G>A	ENST00000275034.4	-	17	2025	c.1858C>T	c.(1858-1860)Cag>Tag	p.Q620*		NM_017934.5	NP_060404	Q8WWQ0	PHIP_HUMAN	pleckstrin homology domain interacting protein	620					insulin receptor signaling pathway|negative regulation of apoptosis|positive regulation of cell proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis	nucleus	insulin receptor binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(10)|kidney(4)|large_intestine(20)|lung(20)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	68		all_cancers(76;0.00125)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.219)		BRCA - Breast invasive adenocarcinoma(397;0.231)		ACTCCCATCTGAGGGATGAGT	0.408000													14	7					0	0	1	0	0
MRPL40	64976	broad.mit.edu	37	22	19423380	19423380	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr22:19423380G>A	ENST00000333130.3	+	4	1169	c.516G>A	c.(514-516)gaG>gaA	p.E172E	HIRA_ENST00000546308.1_Intron|HIRA_ENST00000541063.1_Intron|MRPL40_ENST00000443660.1_3'UTR	NM_003776.2	NP_003767.2	Q9NQ50	RM40_HUMAN	mitochondrial ribosomal protein L40	172					anatomical structure morphogenesis	mitochondrial ribosome|nucleus				endometrium(1)|upper_aerodigestive_tract(1)	2	Colorectal(54;0.0993)					TCCCCTTTGAGAAGGAAGGGC	0.527000													17	31					0	0	1	0	0
STX12	23673	broad.mit.edu	37	1	28116095	28116095	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:28116095G>A	ENST00000373943.4	+	2	266	c.141G>A	c.(139-141)atG>atA	p.M47I	STX12_ENST00000468761.1_3'UTR	NM_177424.2	NP_803173.1	Q86Y82	STX12_HUMAN	syntaxin 12	47					cholesterol efflux|intracellular protein transport|protein stabilization|vesicle-mediated transport	Golgi apparatus|integral to membrane|membrane raft|phagocytic vesicle	SNAP receptor activity			breast(1)|central_nervous_system(1)|large_intestine(3)|lung(3)	8		Colorectal(325;3.46e-05)|all_lung(284;9.43e-05)|Lung NSC(340;0.000185)|Renal(390;0.00121)|Breast(348;0.0021)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;3.96e-24)|Colorectal(126;3.46e-08)|COAD - Colon adenocarcinoma(152;1.83e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00258)|KIRC - Kidney renal clear cell carcinoma(1967;0.00302)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0649)		AGAATTTGATGAGCCAGCTAG	0.408000													8	21					0	0	1	0	0
BTN2A3P	54718	broad.mit.edu	37	6	26431875	26431875	+	RNA	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr6:26431875C>T	ENST00000466808.2	+	0	1823																											TGCTGTTTAACATCACAGTGA	0.502000													15	44					0	0	1	0	0
ZNF816	125893	broad.mit.edu	37	19	53454143	53454143	+	Silent	SNP	A	A	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:53454143A>G	ENST00000357666.4	-	5	1185	c.885T>C	c.(883-885)acT>acC	p.T295T	ZNF321P_ENST00000391777.3_Intron|ZNF816_ENST00000434371.2_Intron|ZNF816_ENST00000444460.2_Silent_p.T295T	NM_001031665.2	NP_001026835.1	Q0VGE8	ZN816_HUMAN	zinc finger protein 816	295					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(10)|lung(9)|stomach(1)|urinary_tract(2)	27						ATGACATCTGAGTGAAGGTCT	0.408000													90	124					0	0	1	0	0
NPY5R	4889	broad.mit.edu	37	4	164272531	164272531	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr4:164272531G>A	ENST00000515560.1	+	4	2628	c.1106G>A	c.(1105-1107)aGa>aAa	p.R369K	NPY5R_ENST00000338566.3_Missense_Mutation_p.R369K|NPY5R_ENST00000506953.1_Missense_Mutation_p.R369K			Q15761	NPY5R_HUMAN	neuropeptide Y receptor Y5	369					cardiac left ventricle morphogenesis|outflow tract morphogenesis	integral to plasma membrane				NS(2)|biliary_tract(1)|breast(1)|endometrium(3)|large_intestine(4)|lung(26)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	42	all_hematologic(180;0.166)	Prostate(90;0.109)				GTTTTCTACAGACTGACCATA	0.328000													9	24					0	0	1	0	0
TIMD4	91937	broad.mit.edu	37	5	156381553	156381553	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr5:156381553C>T	ENST00000274532.2	-	2	329	c.273G>A	c.(271-273)ccG>ccA	p.P91P	TIMD4_ENST00000407087.3_Silent_p.P91P	NM_138379.2	NP_612388.2	Q96H15	TIMD4_HUMAN	T-cell immunoglobulin and mucin domain containing 4	91	Ig-like V-type.					integral to membrane				NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(23)|ovary(2)|skin(2)	37	Renal(175;0.00488)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CATCACCTCTCGGGATAGTCC	0.517000													23	40					0	0	1	0	0
GTPBP3	84705	broad.mit.edu	37	19	17452408	17452408	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:17452408G>C	ENST00000324894.8	+	9	1443	c.1375G>C	c.(1375-1377)Gag>Cag	p.E459Q	GTPBP3_ENST00000598038.1_3'UTR|GTPBP3_ENST00000600625.1_Missense_Mutation_p.E438Q|GTPBP3_ENST00000361619.5_Missense_Mutation_p.E481Q|GTPBP3_ENST00000358792.7_Missense_Mutation_p.E491Q	NM_032620.3|NM_133644.3	NP_116009.2|NP_598399.2	Q969Y2	GTPB3_HUMAN	GTP binding protein 3 (mitochondrial)	459					tRNA modification	mitochondrion	GTP binding|GTPase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(7)|skin(2)|upper_aerodigestive_tract(1)	18						CCTGGCGGCAGAGGCGCTGCG	0.657000													19	54					0	0	1	0	0
FCGR2B	2213	broad.mit.edu	37	1	161641318	161641318	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:161641318C>T	ENST00000367962.4	+	3	397	c.270C>T	c.(268-270)ctC>ctT	p.L90L	FCGR2B_ENST00000428605.2_Silent_p.L90L|FCGR2B_ENST00000367960.5_Silent_p.L83L|FCGR2B_ENST00000403078.3_Silent_p.L90L|FCGR2B_ENST00000236937.9_Silent_p.L90L|FCGR2B_ENST00000358671.5_Silent_p.L90L|FCGR2B_ENST00000367961.4_Silent_p.L83L			P31994	FCG2B_HUMAN	Fc fragment of IgG, low affinity IIb, receptor (CD32)	90	Ig-like C2-type 1.				immune response|interspecies interaction between organisms|regulation of immune response	integral to membrane|plasma membrane	IgG binding|receptor activity					all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	ATGGGAATCTCATTCCCACCC	0.587000			T	?	ALL								17	780					0	0	1	0	0
ADAM23	8745	broad.mit.edu	37	2	207424807	207424807	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:207424807C>T	ENST00000264377.3	+	11	1462	c.1134C>T	c.(1132-1134)cgC>cgT	p.R378R	ADAM23_ENST00000374416.1_Silent_p.R378R|ADAM23_ENST00000374415.3_Silent_p.R378R	NM_003812.2	NP_003803.1	O75077	ADA23_HUMAN	ADAM metallopeptidase domain 23	378	Peptidase M12B.				cell adhesion|central nervous system development|proteolysis	extracellular region|integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			NS(2)|breast(1)|endometrium(6)|kidney(3)|large_intestine(5)|liver(2)|lung(22)|ovary(2)|prostate(3)|skin(3)|stomach(1)|urinary_tract(1)	51				LUSC - Lung squamous cell carcinoma(261;0.0961)|Lung(261;0.182)|Epithelial(149;0.205)		ACCGGCAGCGCATTAAGCAGC	0.473000													10	33					0	0	1	0	0
TREM1	54210	broad.mit.edu	37	6	41250355	41250355	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr6:41250355C>G	ENST00000591620.1	-	2	210	c.184G>C	c.(184-186)Gag>Cag	p.E62Q	TREM1_ENST00000589614.1_Missense_Mutation_p.E62Q|TREM1_ENST00000334475.6_Missense_Mutation_p.E62Q|TREM1_ENST00000244709.4_Missense_Mutation_p.E62Q	NM_001242589.1	NP_001229518.1	Q9NP99	TREM1_HUMAN	triggering receptor expressed on myeloid cells 1	62	Ig-like V-type.				blood coagulation|humoral immune response|intracellular signal transduction|leukocyte migration	extracellular region|integral to membrane|intracellular|plasma membrane	receptor activity			NS(1)|breast(2)|endometrium(2)|large_intestine(5)|lung(5)|skin(1)	16	Ovarian(28;0.0327)|Colorectal(47;0.196)				Glutathione(DB00143)	TTGGGCATCTCTCCGTCCCTT	0.493000													25	80					0	0	1	0	0
SMC5	23137	broad.mit.edu	37	9	72965198	72965198	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr9:72965198G>C	ENST00000361138.5	+	23	3116	c.3058G>C	c.(3058-3060)Gaa>Caa	p.E1020Q	SMC5_ENST00000471372.1_3'UTR	NM_015110.3	NP_055925.2	Q8IY18	SMC5_HUMAN	structural maintenance of chromosomes 5	1020	Ala/Asp-rich (DA-box).				DNA recombination|DNA repair	chromosome|nucleus	ATP binding			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(4)|large_intestine(8)|lung(9)|ovary(2)|prostate(1)|skin(4)	35						AGTAGTTGATGAAATCAATCA	0.363000													17	68					0	0	1	0	0
BFAR	51283	broad.mit.edu	37	16	14738401	14738401	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr16:14738401G>C	ENST00000261658.2	+	2	475	c.198G>C	c.(196-198)aaG>aaC	p.K66N	BFAR_ENST00000426842.2_Missense_Mutation_p.E7Q|BFAR_ENST00000563971.1_Missense_Mutation_p.K66N	NM_016561.2	NP_057645.1	Q9NZS9	BFAR_HUMAN	bifunctional apoptosis regulator	66					anti-apoptosis|apoptosis	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction	structural molecule activity|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(2)|lung(1)|ovary(2)|skin(1)	11						CATCTTCAAAGAAAACAGAAT	0.483000													53	130					0	0	1	0	0
IFT172	26160	broad.mit.edu	37	2	27672403	27672403	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:27672403T>C	ENST00000260570.3	-	38	4290	c.4187A>G	c.(4186-4188)tAt>tGt	p.Y1396C		NM_015662.1	NP_056477.1	Q9UG01	IF172_HUMAN	intraflagellar transport 172 homolog (Chlamydomonas)	1396					cilium assembly	cilium	binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(17)|lung(17)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	43	Acute lymphoblastic leukemia(172;0.155)					GAACTCTTTATAATGCTGGTC	0.488000													25	73					0	0	1	0	0
DUSP11	8446	broad.mit.edu	37	2	73996452	73996452	+	Splice_Site	SNP	T	T	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:73996452T>C	ENST00000443070.1	-	5	580	c.575A>G	c.(574-576)gAt>gGt	p.D192G	DUSP11_ENST00000377706.4_Splice_Site_p.D145G|DUSP11_ENST00000272444.3_Splice_Site_p.D192G|DUSP11_ENST00000480948.1_5'UTR			O75319	DUS11_HUMAN	dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)	145	Tyrosine-protein phosphatase.				RNA processing	nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity|RNA binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(4)|skin(1)	12						AATAAGTTTATCTATAAAAAG	0.358000													11	44					0	0	1	0	0
PTPRS	5802	broad.mit.edu	37	19	5245929	5245929	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:5245929G>A	ENST00000372412.4	-	10	1082	c.849C>T	c.(847-849)gcC>gcT	p.A283A	PTPRS_ENST00000262963.6_Silent_p.A278A|PTPRS_ENST00000588012.1_Silent_p.A269A|PTPRS_ENST00000592099.1_Silent_p.A269A|PTPRS_ENST00000348075.2_Silent_p.A269A|PTPRS_ENST00000587303.1_Silent_p.A282A|PTPRS_ENST00000357368.4_Silent_p.A282A|PTPRS_ENST00000353284.2_Silent_p.A269A|PTPRS_ENST00000588552.1_5'UTR			Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type, S	282	Ig-like C2-type 3.				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|biliary_tract(1)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(9)|ovary(4)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)	61				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		TCAGGTCCTCGGCCCCCTGCA	0.627000													11	29					0	0	1	0	0
TNRC18	84629	broad.mit.edu	37	7	5427897	5427897	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr7:5427897C>T	ENST00000399537.4	-	5	1906	c.1558G>A	c.(1558-1560)Gcc>Acc	p.A520T	TNRC18_ENST00000430969.1_Missense_Mutation_p.A520T			O15417	TNC18_HUMAN	trinucleotide repeat containing 18	520							DNA binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)	11		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		ATCTGCGTGGCGGCGAAGTTG	0.701000													9	18					0	0	1	0	0
ZNF536	9745	broad.mit.edu	37	19	30935694	30935694	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:30935694C>T	ENST00000355537.3	+	2	1372	c.1225C>T	c.(1225-1227)Ccc>Tcc	p.P409S		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	409					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					CCCCAGCGACCCCGAGGTGCC	0.627000													33	37					0	0	1	0	0
WRAP73	49856	broad.mit.edu	37	1	3555346	3555346	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:3555346G>C	ENST00000378322.3	-	4	438	c.380C>G	c.(379-381)tCt>tGt	p.S127C	WRAP73_ENST00000270708.7_Missense_Mutation_p.S127C			Q9P2S5	WRP73_HUMAN	WD repeat containing, antisense to TP73	127						centrosome	protein binding			endometrium(2)|kidney(1)|large_intestine(5)|lung(3)|pancreas(1)	12						TTTGATGTAAGACACGGATTT	0.478000													19	63					0	0	1	0	0
MISP	126353	broad.mit.edu	37	19	757862	757862	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:757862G>A	ENST00000215582.6	+	2	1019	c.916G>A	c.(916-918)Gac>Aac	p.D306N		NM_173481.2	NP_775752.1			mitotic spindle positioning																		GCGTGAGGCAGACCTGCGAGA	0.662000													12	38					0	0	1	0	0
SIRPA	140885	broad.mit.edu	37	20	1902159	1902159	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr20:1902159C>T	ENST00000358771.4	+	3	707	c.555C>T	c.(553-555)ttC>ttT	p.F185F	SIRPA_ENST00000356025.3_Silent_p.F185F|SIRPA_ENST00000400068.3_Silent_p.F185F	NM_001040023.1	NP_001035112.1	P78324	SHPS1_HUMAN	signal-regulatory protein alpha	185	Ig-like C1-type 1.				blood coagulation|cell adhesion|cell junction assembly|leukocyte migration	integral to membrane|plasma membrane	SH3 domain binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(13)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	21				Colorectal(46;0.018)|READ - Rectum adenocarcinoma(1;0.0556)		TGAAATGGTTCAAAAATGGGA	0.587000													33	60					0	0	1	0	0
TTC21A	199223	broad.mit.edu	37	3	39162592	39162592	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:39162592C>T	ENST00000301819.6	+	9	1206	c.1029C>T	c.(1027-1029)ctC>ctT	p.L343L	TTC21A_ENST00000431162.2_Silent_p.L343L|TTC21A_ENST00000440121.1_Silent_p.L294L	NM_145755.2	NP_665698.2	Q8NDW8	TT21A_HUMAN	tetratricopeptide repeat domain 21A	343							binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(9)|lung(23)|ovary(1)|prostate(1)|skin(3)	50				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		TGGGCTATCTCTTCATCCTGA	0.512000													24	70					0	0	1	0	0
KCNG1	3755	broad.mit.edu	37	20	49626342	49626342	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr20:49626342C>G	ENST00000371571.4	-	2	819	c.534G>C	c.(532-534)gaG>gaC	p.E178D	RP5-955M13.4_ENST00000424566.1_RNA|KCNG1_ENST00000396017.3_Missense_Mutation_p.E178D	NM_002237.3	NP_002228.2	Q9UIX4	KCNG1_HUMAN	potassium voltage-gated channel, subfamily G, member 1	178						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(11)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	35						GCTCCACCATCTCCGCGAACT	0.701000													5	33					0	0	1	0	0
OPN4	94233	broad.mit.edu	37	10	88419770	88419770	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr10:88419770C>T	ENST00000372071.2	+	7	1179	c.952C>T	c.(952-954)Ctc>Ttc	p.L318F	OPN4_ENST00000241891.5_Missense_Mutation_p.L307F	NM_001030015.2	NP_001025186.1	Q9UHM6	OPN4_HUMAN	opsin 4	307					phototransduction|protein-chromophore linkage|regulation of circadian rhythm|rhythmic process|visual perception	integral to membrane|plasma membrane	11-cis retinal binding|G-protein coupled photoreceptor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|liver(2)|lung(5)|ovary(3)	18						CCTCTTCGTGCTCTCCTGGGC	0.627000													16	35					0	0	1	0	0
YES1	7525	broad.mit.edu	37	18	756621	756621	+	Silent	SNP	C	C	A	rs138908805		TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr18:756621C>A	ENST00000584307.1	-	2	377	c.207G>T	c.(205-207)acG>acT	p.T69T	YES1_ENST00000577961.1_Silent_p.T74T|YES1_ENST00000314574.4_Silent_p.T69T|YES1_ENST00000577611.1_5'UTR			P07947	YES_HUMAN	v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1	69					blood coagulation|leukocyte migration|regulation of vascular permeability|T cell costimulation	cytosol|plasma membrane	ATP binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)|skin(1)	17					Dasatinib(DB01254)	CTCCAAAAGGCGTTACCCCTG	0.443000													26	57					9.39395e-14	1.00493e-13	1	1	0
PCDHA9	9752	broad.mit.edu	37	5	140389347	140389347	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr5:140389347C>T	ENST00000532602.1	+	4	3711	c.2678C>T	c.(2677-2679)tCt>tTt	p.S893F	PCDHA11_ENST00000398640.2_Missense_Mutation_p.S892F|PCDHA3_ENST00000522353.2_Missense_Mutation_p.S893F|PCDHA7_ENST00000525929.1_Missense_Mutation_p.S880F|PCDHA4_ENST00000512229.2_Intron|PCDHA2_ENST00000526136.1_Missense_Mutation_p.S891F|PCDHA6_ENST00000527624.1_Missense_Mutation_p.S629F|PCDHA6_ENST00000529310.1_Missense_Mutation_p.S893F|PCDHA10_ENST00000506939.2_Missense_Mutation_p.S628F|PCDHA5_ENST00000529619.1_Intron|PCDHA4_ENST00000530339.1_Missense_Mutation_p.S890F|PCDHA10_ENST00000307360.5_Missense_Mutation_p.S891F|PCDHA13_ENST00000289272.2_Missense_Mutation_p.S893F|PCDHA5_ENST00000529859.1_Missense_Mutation_p.S879F|PCDHA12_ENST00000398631.2_Missense_Mutation_p.S884F|PCDHA1_ENST00000394633.3_Missense_Mutation_p.S629F|PCDHA8_ENST00000531613.1_Missense_Mutation_p.S893F|PCDHA13_ENST00000409494.1_Intron|PCDHAC1_ENST00000253807.2_Missense_Mutation_p.S906F|PCDHA1_ENST00000504120.2_Missense_Mutation_p.S893F|PCDHAC2_ENST00000289269.5_Missense_Mutation_p.S950F	NM_031857.1	NP_114063.1														breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(18)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	59			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATCCCAGGATCTCCTGCAATC	0.493000													20	49					0	0	1	0	0
LDLRAP1	26119	broad.mit.edu	37	1	25880456	25880456	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:25880456G>A	ENST00000374338.4	+	2	251	c.132G>A	c.(130-132)gaG>gaA	p.E44E	LDLRAP1_ENST00000488127.1_3'UTR	NM_015627.2	NP_056442.2	Q5SW96	ARH_HUMAN	low density lipoprotein receptor adaptor protein 1	44	PID.				amyloid precursor protein metabolic process|cholesterol homeostasis|cholesterol metabolic process|positive regulation of receptor-mediated endocytosis|receptor internalization|receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport|regulation of establishment of protein localization in plasma membrane|regulation of protein binding	basal plasma membrane|cytosol|early endosome|internal side of plasma membrane|neurofilament|recycling endosome	beta-amyloid binding|clathrin binding|low-density lipoprotein particle receptor binding|phosphatidylinositol-4,5-bisphosphate binding|phosphotyrosine binding|protein binding, bridging|protein complex binding|receptor signaling complex scaffold activity|signaling adaptor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(1)|ovary(1)|skin(1)|urinary_tract(1)	9		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.63e-26)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000728)|STAD - Stomach adenocarcinoma(196;0.000766)|BRCA - Breast invasive adenocarcinoma(304;0.000969)|GBM - Glioblastoma multiforme(114;0.00914)|READ - Rectum adenocarcinoma(331;0.0649)		CGCTGCTGGAGGGGATGCTGT	0.642000													9	24					0	0	1	0	0
DNAH1	25981	broad.mit.edu	37	3	52418835	52418835	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:52418835T>C	ENST00000420323.2	+	53	8617	c.8356T>C	c.(8356-8358)Tcc>Ccc	p.S2786P		NM_015512.4	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	2786	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		CCAGTCGGTGTCCAAGAAGTG	0.572000											OREG0015612	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	12					0	0	1	0	0
GLRA3	8001	broad.mit.edu	37	4	175565132	175565132	+	Silent	SNP	T	T	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr4:175565132T>A	ENST00000274093.3	-	10	1702	c.1200A>T	c.(1198-1200)ccA>ccT	p.P400P	GLRA3_ENST00000340217.5_Silent_p.P385P	NM_006529.2	NP_006520.2	O75311	GLRA3_HUMAN	glycine receptor, alpha 3	400					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity			endometrium(2)|kidney(1)|large_intestine(12)|lung(11)|ovary(3)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	35		Prostate(90;0.00601)|Breast(14;0.0091)|Melanoma(52;0.00959)|Renal(120;0.0183)|all_neural(102;0.0891)|all_hematologic(60;0.107)		all cancers(43;4.99e-18)|Epithelial(43;1.18e-16)|OV - Ovarian serous cystadenocarcinoma(60;5.88e-09)|STAD - Stomach adenocarcinoma(60;0.00442)|GBM - Glioblastoma multiforme(59;0.0102)|LUSC - Lung squamous cell carcinoma(193;0.0421)	Glycine(DB00145)	TGGGGCCCTTTGGAGTCATGC	0.483000													30	68					0	0	1	0	0
OR5W2	390148	broad.mit.edu	37	11	55681567	55681567	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr11:55681567G>A	ENST00000344514.1	-	1	491	c.492C>T	c.(490-492)ttC>ttT	p.F164F		NM_001001960.1	NP_001001960.1	Q8NH69	OR5W2_HUMAN	olfactory receptor, family 5, subfamily W, member 2	164					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(28)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						AGCATAGGCGGAAGGCCAGTG	0.428000													7	35					0	0	1	0	0
LRRC16B	90668	broad.mit.edu	37	14	24533476	24533476	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr14:24533476C>A	ENST00000342740.5	+	32	3155	c.3001C>A	c.(3001-3003)Cag>Aag	p.Q1001K	LRRC16B_ENST00000334420.7_Missense_Mutation_p.Q97K	NM_138360.3	NP_612369.3	Q8ND23	LR16B_HUMAN	leucine rich repeat containing 16B	1001										breast(3)|central_nervous_system(2)|cervix(3)|endometrium(7)|kidney(1)|large_intestine(9)|liver(1)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	52				GBM - Glioblastoma multiforme(265;0.019)		TGGGACTCGTCAGGAGAATGG	0.577000													10	10					0.00621372	0.00627871	1	1	0
ZNF791	163049	broad.mit.edu	37	19	12738585	12738585	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:12738585C>T	ENST00000446165.1	+	3	343	c.181C>T	c.(181-183)Cag>Tag	p.Q61*	ZNF791_ENST00000458122.3_Missense_Mutation_p.A49V|ZNF490_ENST00000465656.1_Intron|ZNF791_ENST00000343325.4_Missense_Mutation_p.A81V|ZNF791_ENST00000540038.1_5'UTR			Q3KP31	ZN791_HUMAN	zinc finger protein 791	0	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(5)|lung(6)|ovary(2)|prostate(3)	19						AGTCAATGTGCAGAAAACTTC	0.413000													23	114					0	0	1	0	0
UBR2	23304	broad.mit.edu	37	6	42541690	42541690	+	Nonsense_Mutation	SNP	T	T	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr6:42541690T>A	ENST00000372899.1	+	2	555	c.297T>A	c.(295-297)tgT>tgA	p.C99*	UBR2_ENST00000372903.2_Nonsense_Mutation_p.C99*|UBR2_ENST00000372901.1_Nonsense_Mutation_p.C99*	NM_015255.2	NP_056070.1	Q8IWV8	UBR2_HUMAN	ubiquitin protein ligase E3 component n-recognin 2	99					cellular response to leucine|chromatin silencing|histone H2A ubiquitination|negative regulation of TOR signaling cascade	nucleus|plasma membrane	leucine binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(10)|kidney(7)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|skin(5)	64	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.004)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.196)			CTCATCTTTGTGGTCGTGTTT	0.368000													15	63					0	0	1	0	0
NDUFV3	4731	broad.mit.edu	37	21	44323351	44323351	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr21:44323351T>C	ENST00000354250.2	+	3	298	c.229T>C	c.(229-231)Tct>Cct	p.S77P	NDUFV3_ENST00000460259.1_3'UTR|NDUFV3_ENST00000340344.4_Intron	NM_021075.3	NP_066553.3	P56181	NDUV3_HUMAN	NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa	0					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I|nucleus	NADH dehydrogenase (ubiquinone) activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(2)|skin(1)	10				STAD - Stomach adenocarcinoma(101;0.0606)	NADH(DB00157)	AGCTGAATTGTCTAAAAACTT	0.478000													24	74					0	0	1	0	0
SNAP91	9892	broad.mit.edu	37	6	84300933	84300933	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr6:84300933C>A	ENST00000428679.2	-	22	2604	c.2011G>T	c.(2011-2013)Gct>Tct	p.A671S	SNAP91_ENST00000521743.1_Missense_Mutation_p.A671S|SNAP91_ENST00000195649.6_Missense_Mutation_p.A671S|SNAP91_ENST00000437520.1_Intron|SNAP91_ENST00000520302.1_Missense_Mutation_p.A641S|SNAP91_ENST00000369694.2_Missense_Mutation_p.A671S|SNAP91_ENST00000439399.2_Missense_Mutation_p.A671S|SNAP91_ENST00000520213.1_Intron|SNAP91_ENST00000521485.1_Missense_Mutation_p.A671S			O60641	AP180_HUMAN	synaptosomal-associated protein, 91kDa	671					clathrin coat assembly	clathrin coat|coated pit|plasma membrane	1-phosphatidylinositol binding|clathrin binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(22)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	37		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;2.91e-07)|all_hematologic(105;0.000337)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0967)		TAATTACCAGCTAGTAGGTCT	0.348000													11	48					3.86212e-05	3.98165e-05	1	1	0
AMH	268	broad.mit.edu	37	19	2249452	2249452	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:2249452G>A	ENST00000221496.4	+	1	143	c.121G>A	c.(121-123)Gaa>Aaa	p.E41K		NM_000479.3	NP_000470	P03971	MIS_HUMAN	anti-Mullerian hormone						cell differentiation|cell-cell signaling|gonadal mesoderm development|Mullerian duct regression|positive regulation of gene expression|sex determination	extracellular space	growth factor activity|hormone activity			lung(2)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CATCTTCCGAGAAGACTTGGA	0.677000									Persistant Mullerian Duct Syndrome (type I and II)				3	9					0	0	1	0	0
TTC38	55020	broad.mit.edu	37	22	46668301	46668301	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr22:46668301G>A	ENST00000381031.3	+	3	257	c.181G>A	c.(181-183)Gat>Aat	p.D61N	TTC38_ENST00000445282.2_Missense_Mutation_p.D61N	NM_017931.2	NP_060401	Q5R3I4	TTC38_HUMAN	tetratricopeptide repeat domain 38	61							binding			endometrium(4)|large_intestine(3)|lung(4)|ovary(1)	12						CAAAGCAGCAGATCCAACCTT	0.522000													14	26					0	0	1	0	0
ATP13A5	344905	broad.mit.edu	37	3	192992879	192992879	+	Silent	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:192992879G>C	ENST00000342358.4	-	30	3726	c.3609C>G	c.(3607-3609)ctC>ctG	p.L1203L	ATP13A5_ENST00000495496.1_5'UTR	NM_198505.2	NP_940907.2	Q4VNC0	AT135_HUMAN	ATPase type 13A5	1203					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			NS(1)|autonomic_ganglia(2)|breast(1)|endometrium(6)|kidney(4)|large_intestine(15)|liver(2)|lung(26)|ovary(5)|prostate(1)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	76	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		CTCCCAATTTGAGTTTTCTTT	0.433000													30	187					0	0	1	0	0
ST13	6767	broad.mit.edu	37	22	41246881	41246881	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr22:41246881C>G	ENST00000216218.3	-	2	595	c.114G>C	c.(112-114)atG>atC	p.M38I		NM_003932.3	NP_003923.2	P50502	F10A1_HUMAN	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)	38				M -> I (in Ref. 1; AAB38382).			protein binding, bridging			cervix(1)|large_intestine(1)|lung(3)|skin(1)	6						CTTTACCACCCATGCTTGAAG	0.299000													10	27					0	0	1	0	0
PXDNL	137902	broad.mit.edu	37	8	52284553	52284553	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr8:52284553C>T	ENST00000356297.4	-	19	3881	c.3781G>A	c.(3781-3783)Ggt>Agt	p.G1261S	PXDNL_ENST00000543296.1_Missense_Mutation_p.G1261S	NM_144651.4	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	1261					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				ATGCTGTCACCATTGTCACAA	0.527000													10	15					0	0	1	0	0
MGME1	92667	broad.mit.edu	37	20	17950511	17950511	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr20:17950511G>A	ENST00000377710.5	+	2	297	c.9G>A	c.(7-9)atG>atA	p.M3I	MGME1_ENST00000377709.1_Missense_Mutation_p.M3I|MGME1_ENST00000377704.4_Missense_Mutation_p.M3I	NM_052865.2	NP_443097.1			mitochondrial genome maintenance exonuclease 1																		GAATGAAGATGAAGTTATTTC	0.413000													12	67					0	0	1	0	0
MME	4311	broad.mit.edu	37	3	154886342	154886342	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:154886342C>G	ENST00000460393.1	+	19	1962	c.1842C>G	c.(1840-1842)aaC>aaG	p.N614K	MME_ENST00000493237.1_Missense_Mutation_p.N614K|MME-AS1_ENST00000484721.1_RNA|MME_ENST00000492661.1_Missense_Mutation_p.N614K|MME_ENST00000360490.2_Missense_Mutation_p.N614K|MME_ENST00000462745.1_Missense_Mutation_p.N614K	NM_000902.3|NM_007287.2	NP_000893.2|NP_009218.2	P08473	NEP_HUMAN	membrane metallo-endopeptidase	614					cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(31)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	CTGCAAGTAACTTTAAGGAGC	0.408000													40	56					0	0	1	0	0
ADAM30	11085	broad.mit.edu	37	1	120436675	120436675	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:120436675G>T	ENST00000369400.1	-	1	2443	c.2285C>A	c.(2284-2286)tCt>tAt	p.S762Y		NM_021794.3	NP_068566.2	Q9UKF2	ADA30_HUMAN	ADAM metallopeptidase domain 30	762	5 X 9 AA approximate repeats.				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(11)|lung(16)|ovary(2)|skin(2)	38	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;1.55e-06)|Lung NSC(69;1.04e-05)|all_epithelial(167;0.00138)		Lung(183;0.0204)|LUSC - Lung squamous cell carcinoma(189;0.117)		TTTTGCTTTAGATTCTTCCTG	0.358000													30	85					3.1745e-13	3.39222e-13	1	1	0
PPRC1	23082	broad.mit.edu	37	10	103899303	103899303	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr10:103899303G>A	ENST00000278070.2	+	5	1077	c.1038G>A	c.(1036-1038)ctG>ctA	p.L346L	PPRC1_ENST00000413464.2_Silent_p.L346L	NM_015062.3	NP_055877.3	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator-related 1	346					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(10)|lung(19)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	56		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		GCGTAGTGCTGGAGATTGTGG	0.602000													36	123					0	0	1	0	0
PCDH8	5100	broad.mit.edu	37	13	53422409	53422409	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr13:53422409T>C	ENST00000377942.3	-	1	366	c.163A>G	c.(163-165)Atg>Gtg	p.M55V	PCDH8_ENST00000338862.4_Missense_Mutation_p.M55V	NM_002590.3	NP_002581.2	O95206	PCDH8_HUMAN	protocadherin 8	55	Cadherin 1.				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(23)|ovary(1)|skin(1)|urinary_tract(1)	36		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		GATACTTTCATATGCAGGTCC	0.622000													35	78					0	0	1	0	0
CTNNA2	1496	broad.mit.edu	37	2	80085171	80085171	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:80085171G>A	ENST00000466387.1	+	8	1055	c.331G>A	c.(331-333)Gca>Aca	p.A111T	CTNNA2_ENST00000541047.1_Missense_Mutation_p.A111T|CTNNA2_ENST00000361291.4_Missense_Mutation_p.A145T|CTNNA2_ENST00000402739.4_Missense_Mutation_p.A111T|CTNNA2_ENST00000496558.1_Missense_Mutation_p.A111T|CTNNA2_ENST00000540488.1_Missense_Mutation_p.A111T			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2	111					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						CTCCGAGTTTGCAGATGACCC	0.592000													33	189					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	34140554	34140554	+	Silent	SNP	A	A	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr15:34140554A>G	ENST00000389232.4	+	94	13630	c.13560A>G	c.(13558-13560)ctA>ctG	p.L4520L	RYR3_ENST00000559917.1_3'UTR|RYR3_ENST00000415757.3_Silent_p.L4515L	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	4520					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TTGATGGCCTATATATCACCG	0.502000													30	32					0	0	1	0	0
FAM189A2	9413	broad.mit.edu	37	9	72003170	72003170	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr9:72003170C>T	ENST00000257515.8	+	10	1373	c.953C>T	c.(952-954)tCg>tTg	p.S318L	FAM189A2_ENST00000455972.1_Missense_Mutation_p.S318L|FAM189A2_ENST00000469179.1_3'UTR|FAM189A2_ENST00000303068.7_Missense_Mutation_p.S153L|FAM189A2_ENST00000377216.3_Missense_Mutation_p.S105L	NM_004816.3	NP_004807.3	Q15884	F1892_HUMAN	family with sequence similarity 189, member A2	318						integral to membrane		p.S318L(1)		endometrium(3)|large_intestine(5)|liver(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	12						TCTAGAGCTTCGCGATGCAGA	0.542000													26	45					0	0	1	0	0
ETF1	2107	broad.mit.edu	37	5	137846293	137846293	+	Silent	SNP	T	T	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr5:137846293T>A	ENST00000499810.2	-	9	1393	c.945A>T	c.(943-945)ccA>ccT	p.P315P	ETF1_ENST00000503014.1_Silent_p.P334P|ETF1_ENST00000360541.5_Silent_p.P348P	NM_001256302.1|NM_001282185.1	NP_001243231.1|NP_001269114.1	P62495	ERF1_HUMAN	eukaryotic translation termination factor 1	348					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|protein methylation|regulation of translational termination	cytoplasm	protein binding|ribosome binding|translation release factor activity, codon specific			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)|urinary_tract(1)	18			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			TTTCTTGCTCTGGAGTTAGAT	0.368000													12	26					0	0	1	0	0
PRPS1L1	221823	broad.mit.edu	37	7	18067312	18067312	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr7:18067312T>C	ENST00000506618.2	-	1	174	c.94A>G	c.(94-96)Act>Gct	p.T32A		NM_175886.2	NP_787082	P21108	PRPS3_HUMAN	phosphoribosyl pyrophosphate synthetase 1-like 1	32					nucleoside metabolic process|ribonucleoside monophosphate biosynthetic process		ATP binding|kinase activity|magnesium ion binding|protein homodimerization activity|ribose phosphate diphosphokinase activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(3)	18	Lung NSC(10;0.0385)|all_lung(11;0.0736)					AATTTCTTAGTCACCACCTTG	0.522000													41	149					0	0	1	0	0
MIA3	375056	broad.mit.edu	37	1	222832114	222832114	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:222832114C>T	ENST00000344922.5	+	19	4683	c.4658C>T	c.(4657-4659)tCa>tTa	p.S1553L	MIA3_ENST00000344441.6_Missense_Mutation_p.S1553L|MIA3_ENST00000340535.7_Missense_Mutation_p.S431L|MIA3_ENST00000344507.1_Intron	NM_198551.2	NP_940953.2	Q5JRA6	MIA3_HUMAN	melanoma inhibitory activity family, member 3	1553					exocytosis|negative regulation of cell adhesion|negative regulation of cell migration|positive regulation of leukocyte migration|protein transport|wound healing	endoplasmic reticulum membrane|integral to membrane	protein binding			breast(5)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(15)|lung(37)|ovary(5)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|urinary_tract(1)	80				GBM - Glioblastoma multiforme(131;0.0199)		CACAGGCTGTCAGCTGCAGAT	0.423000													55	72					0	0	1	0	0
NFAT5	10725	broad.mit.edu	37	16	69726488	69726488	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr16:69726488G>A	ENST00000349945.1	+	14	4030	c.2478G>A	c.(2476-2478)caG>caA	p.Q826Q	NFAT5_ENST00000354436.2_Silent_p.Q902Q|NFAT5_ENST00000393742.2_Silent_p.Q826Q|NFAT5_ENST00000566899.1_Silent_p.Q826Q|NFAT5_ENST00000432919.1_Silent_p.Q920Q|NFAT5_ENST00000567239.1_Silent_p.Q919Q	NM_138714.3	NP_619728.2	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5, tonicity-responsive	902					excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37						AGATGCAACAGAGTATCTGCC	0.478000													27	16					0	0	1	0	0
MIOS	54468	broad.mit.edu	37	7	7625272	7625272	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr7:7625272C>T	ENST00000340080.4	+	7	2075	c.1654C>T	c.(1654-1656)Ctg>Ttg	p.L552L	MIOS_ENST00000405785.1_Silent_p.L552L	NM_019005.3	NP_061878.3	Q9NXC5	MIO_HUMAN	missing oocyte, meiosis regulator, homolog (Drosophila)	552										breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(15)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						TGCAGGAGATCTGAATCTCAA	0.368000													17	49					0	0	1	0	0
OR4N5	390437	broad.mit.edu	37	14	20612488	20612488	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr14:20612488G>A	ENST00000333629.1	+	1	594	c.594G>A	c.(592-594)ctG>ctA	p.L198L		NM_001004724.1	NP_001004724.1	Q8IXE1	OR4N5_HUMAN	olfactory receptor, family 4, subfamily N, member 5	198					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|lung(23)|ovary(1)|skin(2)|urinary_tract(1)	29	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.84e-06)	GBM - Glioblastoma multiforme(265;0.0143)		TGGAGCTTCTGATGGTCTCCA	0.537000													31	94					0	0	1	0	0
PDE4C	5143	broad.mit.edu	37	19	18329157	18329157	+	Missense_Mutation	SNP	G	G	A	rs148755672		TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:18329157G>A	ENST00000355502.3	-	14	2088	c.1217C>T	c.(1216-1218)aCg>aTg	p.T406M	PDE4C_ENST00000598111.2_Intron|PDE4C_ENST00000597297.1_Missense_Mutation_p.T176M|PDE4C_ENST00000447275.3_Missense_Mutation_p.T300M|AC068499.10_ENST00000594805.3_RNA|PDE4C_ENST00000539010.1_Missense_Mutation_p.T175M|PDE4C_ENST00000262805.12_Missense_Mutation_p.T374M|PDE4C_ENST00000594617.3_Missense_Mutation_p.T406M|PDE4C_ENST00000594465.3_Missense_Mutation_p.T406M			Q08493	PDE4C_HUMAN	phosphodiesterase 4C, cAMP-specific	406					signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding	p.T406M(1)		breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(2)|lung(9)|ovary(2)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	33					Dyphylline(DB00651)	GAGGGCGGGCGTAGCCAGCAG	0.667000													67	74					0	0	1	0	0
LTBP1	4052	broad.mit.edu	37	2	33173947	33173947	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:33173947A>C	ENST00000404816.2	+	2	853	c.500A>C	c.(499-501)aAt>aCt	p.N167T	LTBP1_ENST00000354476.3_Missense_Mutation_p.N167T			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	167					negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				TTCAGGGTCAATGTCTGTGGA	0.567000													20	73					0	0	1	0	0
PTCH1	5727	broad.mit.edu	37	9	98270475	98270475	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr9:98270475C>T	ENST00000331920.6	-	1	468	c.169G>A	c.(169-171)Gac>Aac	p.D57N	PTCH1_ENST00000468211.2_Intron|PTCH1_ENST00000437951.1_Intron|PTCH1_ENST00000375274.2_Intron|PTCH1_ENST00000430669.2_Intron	NM_000264.3	NP_000255.2	Q13635	PTC1_HUMAN	patched 1	57					embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity			NS(8)|bone(33)|breast(10)|central_nervous_system(95)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(8)|kidney(2)|large_intestine(18)|lung(22)|meninges(1)|oesophagus(3)|ovary(6)|prostate(2)|skin(262)|upper_aerodigestive_tract(11)|urinary_tract(2)|vulva(1)	490		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				AAGGCGGCGTCGCAGTAGCTG	0.682000													9	31					0	0	1	0	0
DMGDH	29958	broad.mit.edu	37	5	78350089	78350089	+	Missense_Mutation	SNP	C	C	T	rs145775047	byFrequency	TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr5:78350089C>T	ENST00000255189.3	-	4	486	c.458G>A	c.(457-459)cGg>cAg	p.R153Q	DMGDH_ENST00000540686.1_Intron|DMGDH_ENST00000380311.4_Intron	NM_013391.2	NP_037523.2	Q9UI17	M2GD_HUMAN	dimethylglycine dehydrogenase	153					choline metabolic process|glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|dimethylglycine dehydrogenase activity|electron carrier activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(10)|liver(1)|lung(10)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	34		all_lung(232;0.000638)|Lung NSC(167;0.00173)|Ovarian(174;0.0262)|Prostate(461;0.192)		OV - Ovarian serous cystadenocarcinoma(54;6.52e-45)|Epithelial(54;5.96e-40)|all cancers(79;3.56e-35)		CCAGCCAGTCCGAGTCATTTG	0.408000													14	15					0	0	1	0	0
KDM6A	7403	broad.mit.edu	37	X	44929132	44929132	+	Silent	SNP	C	C	T	rs35467614		TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chrX:44929132C>T	ENST00000377967.4	+	17	2273	c.2232C>T	c.(2230-2232)gtC>gtT	p.V744V	KDM6A_ENST00000536777.1_Silent_p.V699V|KDM6A_ENST00000543216.1_Silent_p.V665V|KDM6A_ENST00000382899.4_Silent_p.V751V	NM_021140.2	NP_066963.2	O15550	KDM6A_HUMAN	lysine (K)-specific demethylase 6A	744					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.0?(6)		NS(1)|breast(7)|central_nervous_system(27)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(24)|kidney(24)|large_intestine(9)|liver(1)|lung(21)|oesophagus(11)|pancreas(2)|prostate(5)|skin(1)|soft_tissue(1)|urinary_tract(29)	170						CTGCCAGTGTCGAGGGACTTC	0.478000			"""D, N, F, S"""		"""renal, oesophageal SCC, MM"""								15	21					0	0	1	0	0
PRPF3	9129	broad.mit.edu	37	1	150300860	150300860	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:150300860G>T	ENST00000324862.6	+	4	523	c.358G>T	c.(358-360)Gaa>Taa	p.E120*	PRPF3_ENST00000543398.1_5'UTR|PRPF3_ENST00000467329.1_3'UTR|PRPF3_ENST00000414970.2_Intron	NM_004698.2	NP_004689.1	O43395	PRPF3_HUMAN	pre-mRNA processing factor 3	120					nuclear mRNA splicing, via spliceosome	Cajal body|cytoplasm|nuclear speck|spliceosomal complex	protein binding			breast(1)|kidney(3)|large_intestine(2)|lung(9)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	Lung NSC(24;5.57e-29)|Breast(34;0.000844)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)	Colorectal(1306;0.0149)		TGAGGAGGTGGAAGAAGAGCC	0.498000													36	417					2.75727e-19	2.97268e-19	1	1	0
PYDC1	260434	broad.mit.edu	37	16	31228167	31228167	+	Nonsense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr16:31228167G>C	ENST00000302964.3	-	1	513	c.183C>G	c.(181-183)taC>taG	p.Y61*	TRIM72_ENST00000322122.3_Intron	NM_152901.2	NP_690865.1	Q8WXC3	PYDC1_HUMAN	PYD (pyrin domain) containing 1	61	DAPIN.				innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein kinase activity|positive regulation of interleukin-1 beta secretion|proteolysis|tumor necrosis factor-mediated signaling pathway	IkappaB kinase complex|nucleus	cysteine-type endopeptidase activity|protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(1)	5						CGTAGTCCTCGTAGTAGGAGG	0.692000													14	84					0	0	1	0	0
VPS13B	157680	broad.mit.edu	37	8	100654246	100654246	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr8:100654246A>G	ENST00000358544.2	+	34	5614	c.5503A>G	c.(5503-5505)Att>Gtt	p.I1835V	VPS13B_ENST00000357162.2_Missense_Mutation_p.I1810V|VPS13B_ENST00000395996.1_3'UTR	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	1835					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TCTAAATTTTATTCCCTTTGA	0.378000													19	37					0	0	1	0	0
PTPRC	5788	broad.mit.edu	37	1	198697495	198697495	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:198697495C>T	ENST00000367376.2	+	16	1912	c.1741C>T	c.(1741-1743)Ctg>Ttg	p.L581L	PTPRC_ENST00000442510.2_Silent_p.L583L|PTPRC_ENST00000594404.1_Silent_p.L420L|PTPRC_ENST00000348564.6_Silent_p.L422L|PTPRC_ENST00000352140.3_Silent_p.L533L	NM_002838.4	NP_002829.3	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	581					axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(7)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(22)|lung(41)|ovary(4)|pancreas(2)|prostate(1)|skin(13)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	111						GATAGCATTTCTGGCATTTCT	0.328000													7	60					0	0	1	0	0
RAD9A	5883	broad.mit.edu	37	11	67160162	67160162	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr11:67160162A>G	ENST00000307980.2	+	3	236	c.143A>G	c.(142-144)tAt>tGt	p.Y48C		NM_001243224.1|NM_004584.2	NP_001230153.1|NP_004575.1	Q99638	RAD9A_HUMAN	RAD9 homolog A (S. pombe)	48					DNA damage checkpoint|DNA repair|DNA replication|DNA replication checkpoint	nucleoplasm	3'-5' exonuclease activity|exodeoxyribonuclease III activity|histone deacetylase binding|protein kinase binding|SH3 domain binding			lung(7)|upper_aerodigestive_tract(1)	8			BRCA - Breast invasive adenocarcinoma(15;8.53e-07)			CGCTCTGCCTATGCCTGCTTT	0.637000								Other conserved DNA damage response genes					16	59					0	0	1	0	0
ACTRT3	84517	broad.mit.edu	37	3	169487204	169487204	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:169487204G>A	ENST00000330368.2	-	1	479	c.105C>T	c.(103-105)atC>atT	p.I35I		NM_032487.4	NP_115876.3	Q9BYD9	ARPM1_HUMAN	actin-related protein T3	35						cytoplasm|cytoskeleton											TGGCGCGGCCGATAATGTTCG	0.652000													9	35					0	0	1	0	0
CASZ1	54897	broad.mit.edu	37	1	10699977	10699977	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:10699977G>A	ENST00000377022.3	-	21	4619	c.4302C>T	c.(4300-4302)ttC>ttT	p.F1434F	RP4-734G22.3_ENST00000606802.1_RNA	NM_001079843.2	NP_001073312.1	Q86V15	CASZ1_HUMAN	castor zinc finger 1	1434					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|large_intestine(13)|lung(18)|ovary(2)|prostate(5)|skin(2)|urinary_tract(1)	54	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		CGAAGCGCCGGAAGCCCTCCA	0.612000													6	24					0	0	1	0	0
C1orf111	284680	broad.mit.edu	37	1	162345158	162345158	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:162345158T>C	ENST00000367935.5	-	2	218	c.139A>G	c.(139-141)Agc>Ggc	p.S47G	RP11-565P22.6_ENST00000431696.1_Intron	NM_182581.3	NP_872387.2	Q5T0L3	CA111_HUMAN	chromosome 1 open reading frame 111											central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)	11	all_hematologic(112;0.15)		BRCA - Breast invasive adenocarcinoma(70;0.0938)			TGAGCTGGGCTGGATGCCTCA	0.547000													29	69					0	0	1	0	0
PRKCB	5579	broad.mit.edu	37	16	24043464	24043464	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr16:24043464G>T	ENST00000303531.7	+	4	448	c.296G>T	c.(295-297)cGc>cTc	p.R99L	PRKCB_ENST00000321728.7_Missense_Mutation_p.R99L	NM_002738.6	NP_002729.2	P05771	KPCB_HUMAN	protein kinase C, beta	99					apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding			central_nervous_system(3)|large_intestine(1)|lung(2)|ovary(3)	9					Vitamin E(DB00163)	CAGGACCCCCGCAGCAAACAC	0.532000													14	82					9.31168e-06	9.64103e-06	1	1	0
TACC2	10579	broad.mit.edu	37	10	123843700	123843700	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr10:123843700C>T	ENST00000369005.1	+	4	2025	c.1685C>T	c.(1684-1686)cCa>cTa	p.P562L	TACC2_ENST00000515273.1_Missense_Mutation_p.P562L|TACC2_ENST00000515603.1_Missense_Mutation_p.P562L|TACC2_ENST00000334433.3_Missense_Mutation_p.P562L|TACC2_ENST00000513429.1_Intron|TACC2_ENST00000453444.2_Missense_Mutation_p.P562L|TACC2_ENST00000358010.1_Intron	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	562						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				TCCACAAGCCCAGCCGTGGCT	0.607000													25	51					0	0	1	0	0
DARC	2532	broad.mit.edu	37	1	159175254	159175254	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:159175254G>C	ENST00000537147.1	+	3	868	c.25G>C	c.(25-27)Gag>Cag	p.E9Q	DARC_ENST00000368121.2_Missense_Mutation_p.E11Q|DARC_ENST00000368122.2_Missense_Mutation_p.E9Q|CTA-134P22.2_ENST00000609696.1_RNA			Q16570	DUFFY_HUMAN	Duffy blood group, atypical chemokine receptor	9					defense response	integral to membrane|plasma membrane	C-C chemokine binding|chemokine receptor activity			large_intestine(2)|lung(1)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	8	all_hematologic(112;0.0429)					CCTCCAGGCGGAGCTCTCCCC	0.542000													16	257					0	0	1	0	0
TTC17	55761	broad.mit.edu	37	11	43464907	43464907	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr11:43464907G>A	ENST00000039989.4	+	17	2298	c.2284G>A	c.(2284-2286)Gag>Aag	p.E762K	TTC17_ENST00000299240.6_Missense_Mutation_p.E819K|TTC17_ENST00000526774.1_3'UTR	NM_018259.5	NP_060729.2	Q96AE7	TTC17_HUMAN	tetratricopeptide repeat domain 17	762							binding			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(27)|ovary(5)|prostate(3)|skin(3)	53						TGGTTCTGATGAGATGGAGAA	0.458000													21	41					0	0	1	0	0
PANK3	79646	broad.mit.edu	37	5	167993205	167993205	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr5:167993205C>A	ENST00000239231.6	-	3	764	c.448G>T	c.(448-450)Gac>Tac	p.D150Y		NM_024594.3	NP_078870.1	Q9H999	PANK3_HUMAN	pantothenate kinase 3	150					coenzyme A biosynthetic process	cytoplasm|nucleus	ATP binding|pantothenate kinase activity			NS(1)|cervix(2)|endometrium(2)|large_intestine(3)|lung(4)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	16	Renal(175;0.000159)|Lung NSC(126;0.0441)|all_lung(126;0.0909)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0989)|OV - Ovarian serous cystadenocarcinoma(192;0.147)|Epithelial(171;0.188)		CTGACAGAGTCTATATACAGC	0.408000													32	60					9.78306e-22	1.05592e-21	1	1	0
AFAP1	60312	broad.mit.edu	37	4	7817744	7817744	+	Splice_Site	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr4:7817744C>T	ENST00000420658.1	-	8	1177		c.e8+1		AFAP1_ENST00000358461.2_Splice_Site|AFAP1_ENST00000382543.3_Splice_Site|AFAP1_ENST00000360265.4_Splice_Site	NM_001134647.1	NP_001128119.1	Q8N556	AFAP1_HUMAN	actin filament associated protein 1							actin cytoskeleton|cytoplasm|focal adhesion	actin binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|skin(4)|stomach(2)	32						GCAGAACTCACCTTGCTCCTT	0.378000													17	53					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179417077	179417077	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:179417077C>T	ENST00000589042.1	-	335	90774	c.90550G>A	c.(90550-90552)Gaa>Aaa	p.E30184K	TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E21119K|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E21244K|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E21311K|TTN_ENST00000591111.1_Missense_Mutation_p.E28543K|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.E27616K|TTN-AS1_ENST00000586831.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	28543	Fibronectin type-III 120.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATTTTGTTTTCAGTTTTACTG	0.378000													15	20					0	0	1	0	0
HID1	283987	broad.mit.edu	37	17	72956328	72956328	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr17:72956328G>A	ENST00000425042.2	-	7	821	c.744C>T	c.(742-744)ctC>ctT	p.L248L		NM_030630.2	NP_085133.1			HID1 domain containing																		GGGAGGTGAAGAGGGGCAGGG	0.642000													10	18					0	0	1	0	0
NKTR	4820	broad.mit.edu	37	3	42680347	42680347	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:42680347A>G	ENST00000232978.8	+	13	3339	c.3151A>G	c.(3151-3153)Ata>Gta	p.I1051V	RP4-613B23.1_ENST00000434363.1_RNA|RP4-613B23.1_ENST00000438017.1_RNA|RP4-613B23.1_ENST00000445452.1_RNA	NM_005385.3	NP_005376.2	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence	1051					protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(6)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	41				KIRC - Kidney renal clear cell carcinoma(284;0.24)		CAATGAAACCATAAAAGATAA	0.358000													24	24					0	0	1	0	0
DPYSL4	10570	broad.mit.edu	37	10	134014488	134014488	+	Splice_Site	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr10:134014488G>C	ENST00000338492.4	+	10	1274		c.e10+1		DPYSL4_ENST00000368629.1_Splice_Site|DPYSL4_ENST00000368627.1_Splice_Site	NM_006426.2	NP_006417.2	O14531	DPYL4_HUMAN	dihydropyrimidinase-like 4						axon guidance|pyrimidine base catabolic process	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			NS(1)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		all_cancers(35;4.33e-08)|all_epithelial(44;6.75e-06)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)|Colorectal(31;0.19)		OV - Ovarian serous cystadenocarcinoma(35;7.21e-05)|Epithelial(32;8.01e-05)|all cancers(32;9.29e-05)|BRCA - Breast invasive adenocarcinoma(275;0.206)		GAAATGTGTGGTGAGCACAGG	0.632000													14	14					0	0	1	0	0
ANKRD17	26057	broad.mit.edu	37	4	74008085	74008085	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr4:74008085C>T	ENST00000358602.4	-	13	2219	c.2103G>A	c.(2101-2103)ttG>ttA	p.L701L	ANKRD17_ENST00000330838.6_Silent_p.L701L|ANKRD17_ENST00000509867.2_Silent_p.L588L|ANKRD17_ENST00000514252.1_5'UTR	NM_032217.3	NP_115593.3	O75179	ANR17_HUMAN	ankyrin repeat domain 17	701					interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			NS(3)|breast(2)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(39)|ovary(6)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)	96	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			CTGCTTCTATCAACATAGTTG	0.378000													25	40					0	0	1	0	0
SLC38A3	10991	broad.mit.edu	37	3	50252859	50252859	+	RNA	SNP	T	T	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:50252859T>C	ENST00000420502.1	+	0	494							Q99624	S38A3_HUMAN	solute carrier family 38, member 3						cellular nitrogen compound metabolic process|sodium ion transport	integral to plasma membrane	antiporter activity|L-alanine transmembrane transporter activity|L-asparagine transmembrane transporter activity|L-glutamine transmembrane transporter activity|L-histidine transmembrane transporter activity|symporter activity			breast(1)|cervix(1)|endometrium(1)|lung(3)	6				BRCA - Breast invasive adenocarcinoma(193;0.000275)|KIRC - Kidney renal clear cell carcinoma(197;0.00548)|Kidney(197;0.00615)	L-Asparagine(DB00174)|L-Glutamine(DB00130)|L-Histidine(DB00117)	AGCTACTCCATCCACCTGCTA	0.592000													33	63					0	0	1	0	0
GDI2	2665	broad.mit.edu	37	10	5827169	5827169	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr10:5827169A>G	ENST00000380191.4	-	6	945	c.655T>C	c.(655-657)Tat>Cat	p.Y219H	GDI2_ENST00000380181.3_Missense_Mutation_p.Y174H|GDI2_ENST00000380132.4_Missense_Mutation_p.Y223H	NM_001115156.1|NM_001494.3	NP_001108628.1|NP_001485.2	P50395	GDIB_HUMAN	GDP dissociation inhibitor 2	219					protein transport|small GTPase mediated signal transduction	cell surface|cytosol|membrane	protein binding|Rab GDP-dissociation inhibitor activity			NS(1)|breast(1)|large_intestine(1)|lung(6)|urinary_tract(1)	10						CTTTTGCCATATCTTGCCAAA	0.393000													22	60					0	0	1	0	0
TOPORS	10210	broad.mit.edu	37	9	32542984	32542984	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr9:32542984C>T	ENST00000360538.2	-	3	1655	c.1539G>A	c.(1537-1539)gtG>gtA	p.V513V	TOPORS_ENST00000379858.1_Silent_p.V448V	NM_005802.4	NP_005793.2	Q9NS56	TOPRS_HUMAN	topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase	513	Interaction with SUMO1.|Interaction with TOP1.|Interaction with p53/TP53.|Required for sumoylation and localization to discrete nuclear foci.				DNA damage response, signal transduction resulting in induction of apoptosis|maintenance of protein location in nucleus|proteasomal ubiquitin-dependent protein catabolic process|protein sumoylation|transcription, DNA-dependent	nuclear speck|PML body	antigen binding|DNA binding|DNA topoisomerase I binding|SUMO ligase activity|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(6)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	12			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.0018)		CTTGTGTCTTCACTGTCTCCA	0.418000													17	128					0	0	1	0	0
ABCC6	368	broad.mit.edu	37	16	16259558	16259558	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr16:16259558G>A	ENST00000205557.7	-	23	3257	c.3228C>T	c.(3226-3228)gtC>gtT	p.V1076V		NM_001171.5	NP_001162	O95255	MRP6_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	1076	ABC transmembrane type-1 2.				response to drug|visual perception	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(10)|lung(10)|ovary(1)|skin(6)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		CCACCAGGCTGACCTCCAGGA	0.587000													17	117					0	0	1	0	0
ZNF638	27332	broad.mit.edu	37	2	71592714	71592714	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:71592714G>A	ENST00000409544.1	+	6	2503	c.1873G>A	c.(1873-1875)Gct>Act	p.A625T	ZNF638_ENST00000377802.2_Missense_Mutation_p.A625T|ZNF638_ENST00000264447.4_Missense_Mutation_p.A625T|ZNF638_ENST00000355812.3_Missense_Mutation_p.A625T|ZNF638_ENST00000410075.1_3'UTR	NM_001252612.1	NP_001239541.1	Q14966	ZN638_HUMAN	zinc finger protein 638	625					RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|lung(28)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|urinary_tract(1)	63						ACCTACAAGCGCTACAAAGAG	0.373000													17	53					0	0	1	0	0
SSBP3	23648	broad.mit.edu	37	1	54708955	54708955	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:54708955C>T	ENST00000371320.3	-	10	1079	c.669G>A	c.(667-669)atG>atA	p.M223I	SSBP3_ENST00000357475.4_Missense_Mutation_p.M203I|SSBP3_ENST00000371319.3_Missense_Mutation_p.M196I|SSBP3_ENST00000417664.2_Missense_Mutation_p.M113I|SSBP3_ENST00000326956.7_5'UTR	NM_145716.2	NP_663768.1	Q9BWW4	SSBP3_HUMAN	single stranded DNA binding protein 3	223	Gly-rich.|Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	single-stranded DNA binding			central_nervous_system(2)|endometrium(3)|large_intestine(1)|lung(3)|ovary(1)|urinary_tract(1)	11						GTGGTGGTCTCATGCCGCTGC	0.567000													41	109					0	0	1	0	0
ZMYM5	9205	broad.mit.edu	37	13	20398869	20398869	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr13:20398869A>C	ENST00000337963.4	-	8	2022	c.1758T>G	c.(1756-1758)gaT>gaG	p.D586E		NM_001142684.1	NP_001136156.1	Q9UJ78	ZMYM5_HUMAN	zinc finger, MYM-type 5	586						nucleus	zinc ion binding			kidney(1)|large_intestine(5)|lung(9)	15		all_cancers(29;2.96e-22)|all_epithelial(30;3.76e-20)|all_lung(29;4.38e-20)|Lung NSC(5;5.8e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.61e-05)|Epithelial(112;4.89e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00171)|Lung(94;0.00942)|LUSC - Lung squamous cell carcinoma(192;0.0431)		aaaacacagaatcttttgagg	0.328000													7	6					0	0	1	0	0
OR9K2	441639	broad.mit.edu	37	12	55524293	55524293	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr12:55524293G>A	ENST00000305377.5	+	1	829	c.741G>A	c.(739-741)gtG>gtA	p.V247V		NM_001005243.1	NP_001005243.1	Q8NGE7	OR9K2_HUMAN	olfactory receptor, family 9, subfamily K, member 2	247					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(3)|central_nervous_system(1)|kidney(3)|large_intestine(3)|lung(14)|pancreas(1)|prostate(2)|skin(2)	31						TGTATATTGTGTCCACAGTTC	0.383000													37	51					0	0	1	0	0
SESN1	27244	broad.mit.edu	37	6	109311966	109311966	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr6:109311966C>T	ENST00000436639.2	-	8	2051	c.1306G>A	c.(1306-1308)Gaa>Aaa	p.E436K	SESN1_ENST00000302071.2_Missense_Mutation_p.E311K|SESN1_ENST00000356644.7_Missense_Mutation_p.E377K	NM_014454.2	NP_055269.1	Q9Y6P5	SESN1_HUMAN	sestrin 1	377					cell cycle arrest|negative regulation of cell proliferation|response to DNA damage stimulus	nucleus				cervix(1)|large_intestine(3)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	10		all_cancers(87;6.45e-05)|Acute lymphoblastic leukemia(125;3.55e-10)|all_hematologic(75;1.68e-07)|all_epithelial(87;0.0106)|Colorectal(196;0.0637)		Epithelial(106;0.0014)|BRCA - Breast invasive adenocarcinoma(108;0.00146)|all cancers(137;0.0031)|OV - Ovarian serous cystadenocarcinoma(136;0.0117)		TGAAATTTTTCATCAATCAAC	0.353000													8	43					0	0	1	0	0
RAB8A	4218	broad.mit.edu	37	19	16222778	16222778	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:16222778T>C	ENST00000300935.3	+	1	340	c.67T>C	c.(67-69)Tgt>Cgt	p.C23R	RAB8A_ENST00000588105.1_3'UTR|RAB8A_ENST00000586682.1_Missense_Mutation_p.C23R	NM_005370.4	NP_005361.2	P61006	RAB8A_HUMAN	RAB8A, member RAS oncogene family	23					cilium assembly|Golgi vesicle fusion to target membrane|protein transport|small GTPase mediated signal transduction|vesicle docking involved in exocytosis	Golgi apparatus|nonmotile primary cilium|perinuclear region of cytoplasm|plasma membrane	GTP binding|protein binding			endometrium(2)|large_intestine(1)|lung(2)|prostate(2)|skin(1)	8						GGGGAAGACCTGTGTCCTGTT	0.617000													45	167					0	0	1	0	0
VPS13C	54832	broad.mit.edu	37	15	62254954	62254954	+	Silent	SNP	A	A	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr15:62254954A>G	ENST00000261517.5	-	33	3502	c.3429T>C	c.(3427-3429)caT>caC	p.H1143H	VPS13C_ENST00000395898.3_Silent_p.H1100H|VPS13C_ENST00000395896.4_Silent_p.H1143H|VPS13C_ENST00000249837.3_Silent_p.H1100H	NM_020821.2	NP_065872.1	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13 homolog C (S. cerevisiae)	1143					protein localization					NS(3)|breast(4)|endometrium(4)|kidney(9)|large_intestine(26)|lung(46)|ovary(5)|prostate(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	117						CTACTTTCTTATGAACTGTCT	0.313000													7	11					0	0	1	0	0
GUCY2F	2986	broad.mit.edu	37	X	108628458	108628458	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chrX:108628458C>T	ENST00000218006.2	-	16	3301	c.3010G>A	c.(3010-3012)Gga>Aga	p.G1004R		NM_001522.2	NP_001513.2	P51841	GUC2F_HUMAN	guanylate cyclase 2F, retinal	1004	Guanylate cyclase.				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity	p.G1004R(1)		breast(3)|central_nervous_system(2)|endometrium(5)|kidney(6)|large_intestine(14)|lung(33)|prostate(3)|skin(1)	67						ACAGTGTCTCCAAACAAGCAG	0.502000													24	35					0	0	1	0	0
ACO1	48	broad.mit.edu	37	9	32425899	32425899	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr9:32425899G>A	ENST00000309951.6	+	11	1390	c.1252G>A	c.(1252-1254)Gat>Aat	p.D418N	ACO1_ENST00000541043.1_Missense_Mutation_p.D319N|ACO1_ENST00000379923.1_Missense_Mutation_p.D418N	NM_002197.2	NP_002188.1	P21399	ACOC_HUMAN	aconitase 1, soluble						citrate metabolic process|response to iron(II) ion|tricarboxylic acid cycle	cytosol|endoplasmic reticulum|Golgi apparatus	4 iron, 4 sulfur cluster binding|aconitate hydratase activity|citrate hydro-lyase (cis-aconitate-forming) activity|iron-responsive element binding|isocitrate hydro-lyase (cis-aconitate-forming) activity|metal ion binding|protein binding			breast(1)|endometrium(7)|kidney(5)|large_intestine(6)|lung(6)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	30			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;3.94e-06)		CTTTATCTATGATAACACTGA	0.378000													18	85					0	0	1	0	0
BCAR1	9564	broad.mit.edu	37	16	75269218	75269218	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr16:75269218C>G	ENST00000546196.1	-	5	3144	c.1492G>C	c.(1492-1494)Ggc>Cgc	p.G498R	BCAR1_ENST00000420641.3_Missense_Mutation_p.G545R|BCAR1_ENST00000393422.2_Missense_Mutation_p.G545R|BCAR1_ENST00000393420.6_Missense_Mutation_p.G545R|BCAR1_ENST00000418647.3_Missense_Mutation_p.G573R|BCAR1_ENST00000535626.2_Missense_Mutation_p.G379R|BCAR1_ENST00000162330.5_Missense_Mutation_p.G527R|BCAR1_ENST00000538440.2_Missense_Mutation_p.G527R|BCAR1_ENST00000542031.2_Missense_Mutation_p.G525R|BCAR1_ENST00000566982.1_5'UTR			P56945	BCAR1_HUMAN	breast cancer anti-estrogen resistance 1	527	Ser-rich.				actin filament organization|B cell receptor signaling pathway|blood coagulation|cell adhesion|cell division|cell migration|cell proliferation|epidermal growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|integrin-mediated signaling pathway|nerve growth factor receptor signaling pathway|platelet-derived growth factor receptor signaling pathway|positive regulation of cell migration|regulation of apoptosis|regulation of cell growth|T cell receptor signaling pathway	cytosol|focal adhesion|membrane fraction|ruffle	protein kinase binding|protein phosphatase binding|SH3 domain binding|signal transducer activity			breast(2)|central_nervous_system(5)|endometrium(1)|kidney(6)|large_intestine(1)|liver(1)|lung(13)|ovary(1)|prostate(3)|upper_aerodigestive_tract(2)	35				BRCA - Breast invasive adenocarcinoma(221;0.169)		GCAGCATTGCCCACCGCGCTG	0.647000													47	16					0	0	1	0	0
SEPT4	5414	broad.mit.edu	37	17	56598376	56598376	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr17:56598376C>T	ENST00000457347.2	-	11	1449	c.1305G>A	c.(1303-1305)gtG>gtA	p.V435V	SEPT4_ENST00000393086.1_Silent_p.V401V|SEPT4_ENST00000317268.3_Silent_p.V420V|SEPT4_ENST00000317256.6_Silent_p.V401V|SEPT4_ENST00000583114.1_Silent_p.V273V|RP11-112H10.4_ENST00000580589.1_RNA|SEPT4_ENST00000426861.1_3'UTR|SEPT4_ENST00000579371.1_Silent_p.V321V|SEPT4_ENST00000580844.1_Silent_p.V321V|SEPT4_ENST00000412945.3_Silent_p.V412V	NM_001256782.1	NP_001243711.1	O43236	SEPT4_HUMAN	septin 4	420					apoptosis|cell cycle|cytokinesis|regulation of apoptosis	cytoskeleton|mitochondrion|nucleus	GTP binding|GTPase activity|protein binding|structural molecule activity			NS(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	18	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TCCGTTCCTTCACCACCAGGC	0.547000											OREG0024614	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	65	94					0	0	1	0	0
TTC7B	145567	broad.mit.edu	37	14	91113338	91113338	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr14:91113338T>C	ENST00000357056.2	-	14	1668	c.1547A>G	c.(1546-1548)cAa>cGa	p.Q516R	TTC7B_ENST00000328459.6_Missense_Mutation_p.Q516R|RP11-1078H9.5_ENST00000557007.1_RNA			Q86TV6	TTC7B_HUMAN	tetratricopeptide repeat domain 7B	516							binding			NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	36		Melanoma(154;0.222)				GAAAGCTGCTTGGTGATCTGT	0.463000													38	21					0	0	1	0	0
RBM43	375287	broad.mit.edu	37	2	152109295	152109295	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:152109295G>A	ENST00000331426.5	-	3	440	c.289C>T	c.(289-291)Ctc>Ttc	p.L97F		NM_198557.2	NP_940959.1	Q6ZSC3	RBM43_HUMAN	RNA binding motif protein 43	97	RRM.						nucleotide binding|RNA binding			endometrium(2)|large_intestine(3)|lung(2)|ovary(1)	8				BRCA - Breast invasive adenocarcinoma(221;0.131)		GAGACTCTGAGAGAGACTGTG	0.428000													15	69					0	0	1	0	0
ALG1L2	644974	broad.mit.edu	37	3	129813313	129813313	+	RNA	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:129813313C>G	ENST00000507643.1	+	0	456							C9J202	AG1L2_HUMAN							biosynthetic process		transferase activity, transferring glycosyl groups										ACATCCAGGTCTGCATCCCCT	0.612000													7	55					0	0	1	0	0
HRH4	59340	broad.mit.edu	37	18	22040777	22040777	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr18:22040777A>G	ENST00000256906.4	+	1	185	c.85A>G	c.(85-87)Ata>Gta	p.I29V	HRH4_ENST00000426880.2_Missense_Mutation_p.I29V	NM_001160166.1|NM_021624.3	NP_001153638.1|NP_067637.2	Q9H3N8	HRH4_HUMAN	histamine receptor H4	29						integral to membrane|plasma membrane	histamine receptor activity			endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22	all_cancers(21;0.000545)|all_epithelial(16;6.56e-06)|Lung NSC(20;0.0027)|all_lung(20;0.0085)|Colorectal(14;0.0361)|Ovarian(20;0.0991)				Clozapine(DB00363)	AGCTTTTGCTATAATGCTAGG	0.338000													40	25					0	0	1	0	0
LAMTOR5	10542	broad.mit.edu	37	1	110948964	110948964	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:110948964C>T	ENST00000474861.2	-	2	676	c.70G>A	c.(70-72)Gat>Aat	p.D24N	LAMTOR5-AS1_ENST00000590413.1_RNA|LAMTOR5_ENST00000602318.1_Missense_Mutation_p.D25N|LAMTOR5_ENST00000602858.1_Missense_Mutation_p.D13N|LAMTOR5_ENST00000483260.1_Missense_Mutation_p.D24N|LAMTOR5_ENST00000256644.4_Missense_Mutation_p.D107N					late endosomal/lysosomal adaptor, MAPK and MTOR activator 5																		CCTTGTGAATCTGTGCACAGG	0.383000													12	22					0	0	1	0	0
KIAA1586	57691	broad.mit.edu	37	6	56919288	56919288	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr6:56919288A>G	ENST00000370733.4	+	4	2198	c.1991A>G	c.(1990-1992)tAt>tGt	p.Y664C	KIAA1586_ENST00000545356.1_Missense_Mutation_p.Y637C	NM_020931.2	NP_065982.1	Q9HCI6	K1586_HUMAN	KIAA1586	664							nucleic acid binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(9)|skin(1)	18	Lung NSC(77;0.0969)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			ATTTTAAAATATGAAGTTGAT	0.269000													5	24					0	0	1	0	0
KIAA1614	57710	broad.mit.edu	37	1	180904393	180904393	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:180904393G>T	ENST00000367588.4	+	5	1403	c.1348G>T	c.(1348-1350)Gtg>Ttg	p.V450L	KIAA1614_ENST00000367587.1_Missense_Mutation_p.V71L	NM_020950.1	NP_066001.1	Q5VZ46	K1614_HUMAN	KIAA1614	450										NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(12)|ovary(5)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	33						GCCGTCGCACGTGCGCTTTGA	0.701000													4	6					0.014758	0.0148657	1	1	0
NOTCH2	4853	broad.mit.edu	37	1	120466574	120466574	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:120466574G>A	ENST00000256646.2	-	26	4764	c.4545C>T	c.(4543-4545)gaC>gaT	p.D1515D		NM_024408.3	NP_077719.2	Q04721	NOTC2_HUMAN	notch 2	1515	Negative regulatory region (NRR).				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			breast(4)|central_nervous_system(6)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(9)|kidney(9)|large_intestine(19)|liver(1)|lung(57)|ovary(4)|pancreas(1)|prostate(7)|skin(24)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	158	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		CACAGTGGTTGTCTTTGAAGT	0.502000			"""N, F, Mis"""		"""marginal zone lymphoma, DLBCL"""				Alagille Syndrome				11	22					0	0	1	0	0
PKM	5315	broad.mit.edu	37	15	72494883	72494883	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr15:72494883C>G	ENST00000335181.5	-	9	1322	c.1219G>C	c.(1219-1221)Gac>Cac	p.D407H	PKM_ENST00000449901.2_Missense_Mutation_p.D392H|PKM_ENST00000565154.1_Intron|PKM_ENST00000565184.1_Intron|PKM_ENST00000319622.6_Intron|PKM_ENST00000389093.3_Intron|PKM_ENST00000568459.1_Intron|PKM_ENST00000568883.1_Intron	NM_002654.4	NP_002645.3			pyruvate kinase, muscle											endometrium(1)|lung(7)	8						TCTGTGGGGTCGCTGGTAATG	0.617000													8	14					0	0	1	0	0
SLCO4A1	28231	broad.mit.edu	37	20	61296285	61296285	+	Splice_Site	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr20:61296285G>A	ENST00000217159.1	+	6	1326		c.e6-1		SLCO4A1_ENST00000370507.1_Splice_Site|RP11-93B14.5_ENST00000451648.1_RNA|RP11-93B14.5_ENST00000411824.1_RNA|RP11-93B14.5_ENST00000433126.1_RNA	NM_016354.3	NP_057438.3	Q96BD0	SO4A1_HUMAN	solute carrier organic anion transporter family, member 4A1						sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			endometrium(6)|kidney(2)|large_intestine(1)|lung(7)|ovary(3)|prostate(2)	21	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;2.33e-06)			cctctgcccAGCTCCATCTGG	0.642000													15	30					0	0	1	0	0
RAMP1	10267	broad.mit.edu	37	2	238785966	238785966	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:238785966C>T	ENST00000254661.4	+	2	285	c.153C>T	c.(151-153)gtC>gtT	p.V51V	RAMP1_ENST00000404910.2_Silent_p.V29V|RAMP1_ENST00000403885.1_Silent_p.V29V|RAMP1_ENST00000409726.1_Silent_p.V29V	NM_005855.2	NP_005846.1	O60894	RAMP1_HUMAN	receptor (G protein-coupled) activity modifying protein 1	51					intracellular protein transport|regulation of G-protein coupled receptor protein signaling pathway	integral to plasma membrane	protein transporter activity			kidney(1)|large_intestine(1)|lung(2)	4		Breast(86;0.000596)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;9.56e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.49e-11)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;8.49e-08)|BRCA - Breast invasive adenocarcinoma(100;0.00013)|Lung(119;0.0119)|LUSC - Lung squamous cell carcinoma(224;0.0288)	Pramlintide(DB01278)	TGGAGGCCGTCGGGGAGACGC	0.657000													22	27					0	0	1	0	0
FGF12	2257	broad.mit.edu	37	3	192125872	192125872	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:192125872C>T	ENST00000454309.2	-	1	966	c.141G>A	c.(139-141)ggG>ggA	p.G47G	FGF12_ENST00000430714.1_Intron|FGF12_ENST00000445105.2_Intron|FGF12_ENST00000264730.3_Intron|FGF12_ENST00000450716.1_Intron	NM_021032.4	NP_066360.1	P61328	FGF12_HUMAN	fibroblast growth factor 12	47					cell-cell signaling|heart development|JNK cascade|nervous system development|signal transduction	extracellular space|nucleus	growth factor activity|heparin binding			endometrium(1)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	30	all_cancers(143;1.72e-08)|Ovarian(172;0.0634)|Breast(254;0.247)	Lung NSC(153;0.21)	LUSC - Lung squamous cell carcinoma(58;5.45e-06)|Lung(62;6.17e-06)	GBM - Glioblastoma multiforme(46;0.00032)		TGCTGAACACCCCGAGGACGT	0.692000													37	186					0	0	1	0	0
NDEL1	81565	broad.mit.edu	37	17	8350201	8350201	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr17:8350201G>A	ENST00000334527.7	+	4	567	c.370G>A	c.(370-372)Gac>Aac	p.D124N	NDEL1_ENST00000585098.1_Intron|NDEL1_ENST00000380025.4_Missense_Mutation_p.D124N|NDEL1_ENST00000402554.3_Missense_Mutation_p.D124N|NDEL1_ENST00000299734.7_Missense_Mutation_p.D124N	NM_030808.4	NP_110435.1	Q9GZM8	NDEL1_HUMAN	nudE neurodevelopment protein 1-like 1	124	Interaction with KATNB1 (By similarity).|Required for interaction with PAFAH1B1.|Self-association (By similarity).				chromosome segregation|mitotic prometaphase	condensed chromosome kinetochore|cytosol|microtubule|spindle				large_intestine(6)|lung(4)|skin(3)	13						GGCCAACGACGACCTGGAGCG	0.428000													3	20					0	0	1	0	0
MYH13	8735	broad.mit.edu	37	17	10222154	10222154	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr17:10222154C>T	ENST00000418404.3	-	26	3854	c.3691G>A	c.(3691-3693)Gag>Aag	p.E1231K	MYH13_ENST00000252172.4_Missense_Mutation_p.E1231K			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	1231					muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						TCGTCAATCTCCATCTTCAGC	0.562000													25	72					0	0	1	0	0
PIK3C2B	5287	broad.mit.edu	37	1	204413285	204413285	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:204413285C>T	ENST00000367187.3	-	19	3334	c.2778G>A	c.(2776-2778)ctG>ctA	p.L926L	PIK3C2B_ENST00000424712.2_Silent_p.L898L	NM_002646.3	NP_002637.3	O00750	P3C2B_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta	926					cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(4)|large_intestine(11)|lung(24)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	52	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			ATTCATACTTCAGGGCCTGTT	0.453000													7	45					0	0	1	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54925981	54925981	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr12:54925981A>G	ENST00000293373.6	+	26	2888	c.2809A>G	c.(2809-2811)Atg>Gtg	p.M937V	NCKAP1L_ENST00000545638.2_Missense_Mutation_p.M887V	NM_005337.4	NP_005328.2	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	937					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(37)|ovary(3)|prostate(3)|skin(3)|stomach(2)	80						CCCATTTCTTATGGGTCCCAT	0.408000													19	15					0	0	1	0	0
PHKA1	5255	broad.mit.edu	37	X	71932685	71932685	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chrX:71932685C>T	ENST00000373545.3	-	2	611	c.173G>A	c.(172-174)gGc>gAc	p.G58D	PHKA1_ENST00000541944.1_Missense_Mutation_p.G58D|PHKA1_ENST00000373539.3_Missense_Mutation_p.G58D|PHKA1_ENST00000339490.3_Missense_Mutation_p.G58D|PHKA1_ENST00000373542.4_Missense_Mutation_p.G58D			P46020	KPB1_HUMAN	phosphorylase kinase, alpha 1 (muscle)	58					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(2)|lung(18)|ovary(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	52	Renal(35;0.156)					ATAGGCCAGGCCCAAACCCCA	0.478000													8	25					0	0	1	0	0
ZNF292	23036	broad.mit.edu	37	6	87965030	87965030	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr6:87965030G>C	ENST00000369577.3	+	8	1726	c.1683G>C	c.(1681-1683)caG>caC	p.Q561H	ZNF292_ENST00000339907.4_Missense_Mutation_p.Q556H	NM_015021.1	NP_055836.1	O60281	ZN292_HUMAN	zinc finger protein 292	561					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(27)|lung(21)|ovary(4)|prostate(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	89		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		GACATGCTCAGAAACATTACA	0.368000													11	17					0	0	1	0	0
EXOC4	60412	broad.mit.edu	37	7	133682304	133682304	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr7:133682304A>T	ENST00000253861.4	+	15	2295	c.2266A>T	c.(2266-2268)Atc>Ttc	p.I756F	EXOC4_ENST00000541309.1_Missense_Mutation_p.I44F|EXOC4_ENST00000539845.1_Missense_Mutation_p.I655F|EXOC4_ENST00000545148.1_Missense_Mutation_p.I366F	NM_021807.3	NP_068579.3	Q96A65	EXOC4_HUMAN	exocyst complex component 4	756					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(16)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	50		Esophageal squamous(399;0.129)				GTCAGAGCAGATCATGCAGAC	0.483000													12	21					0	0	1	0	0
OR4C16	219428	broad.mit.edu	37	11	55340025	55340025	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr11:55340025T>G	ENST00000314634.3	+	1	422	c.422T>G	c.(421-423)gTt>gGt	p.V141G		NM_001004701.2	NP_001004701.2	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C, member 16 (gene/pseudogene)	141					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(28)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	41		all_epithelial(135;0.0748)				GTCTGTGGTGTTTTGATGGCT	0.502000													47	111					0	0	1	0	0
FASTKD3	79072	broad.mit.edu	37	5	7863022	7863022	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr5:7863022C>T	ENST00000264669.5	-	4	1749	c.1613G>A	c.(1612-1614)aGa>aAa	p.R538K	FASTKD3_ENST00000513658.1_5'UTR|MTRR_ENST00000502509.1_Intron	NM_024091.3	NP_076996.2	Q14CZ7	FAKD3_HUMAN	FAST kinase domains 3	538					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|liver(2)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						CTTCACATATCTATAAAGCTG	0.378000													87	109					0	0	1	0	0
TAF11	6882	broad.mit.edu	37	6	34855677	34855677	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr6:34855677C>T	ENST00000361288.4	-	1	189	c.58G>A	c.(58-60)Gag>Aag	p.E20K	TAF11_ENST00000420584.2_Missense_Mutation_p.E20K	NM_005643.3	NP_005634.1	Q15544	TAF11_HUMAN	TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa	20					positive regulation by host of viral transcription|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	transcription factor TFIID complex	protein N-terminus binding|thyroid hormone receptor binding|transcription coactivator activity|vitamin D receptor binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(1)	6						GCGGCCGTCTCATCCGACTCC	0.622000													50	108					0	0	1	0	0
KNSTRN	90417	broad.mit.edu	37	15	40683705	40683705	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr15:40683705G>A	ENST00000416151.2	+	7	812	c.697G>A	c.(697-699)Gag>Aag	p.E233K	KNSTRN_ENST00000448395.2_Intron|KNSTRN_ENST00000608100.1_Missense_Mutation_p.E155K|KNSTRN_ENST00000249776.8_Missense_Mutation_p.E233K	NM_001142761.1	NP_001136233.1			kinetochore-localized astrin/SPAG5 binding protein																		TTTAGGCAGTGAGACCCTGGC	0.478000													12	33					0	0	1	0	0
RLIM	51132	broad.mit.edu	37	X	73811494	73811494	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chrX:73811494C>G	ENST00000332687.6	-	4	1874	c.1656G>C	c.(1654-1656)caG>caC	p.Q552H	RLIM_ENST00000349225.2_Missense_Mutation_p.Q552H	NM_016120.3	NP_057204.2	Q9NVW2	RNF12_HUMAN	ring finger protein, LIM domain interacting	552					random inactivation of X chromosome|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|transcriptional repressor complex	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						AGTTGTCAATCTGTTCTTTGG	0.393000													11	16					0	0	1	0	0
SPAG5	10615	broad.mit.edu	37	17	26911177	26911177	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr17:26911177C>G	ENST00000321765.5	-	13	2735	c.2403G>C	c.(2401-2403)gaG>gaC	p.E801D		NM_006461.3	NP_006452.3	Q96R06	SPAG5_HUMAN	sperm associated antigen 5	801					cell division|mitosis|phosphatidylinositol-mediated signaling|spindle organization	condensed chromosome kinetochore|cytoplasm|spindle pole	protein binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(17)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	43	Lung NSC(42;0.00431)					CCTCCAAGGTCTCTTTCAGGT	0.512000													31	99					0	0	1	0	0
MBOAT7	79143	broad.mit.edu	37	19	54677870	54677870	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:54677870G>A	ENST00000245615.1	-	8	1767	c.1287C>T	c.(1285-1287)atC>atT	p.I429I	MBOAT7_ENST00000431666.2_Silent_p.I356I|MBOAT7_ENST00000338624.6_Silent_p.I356I	NM_024298.3	NP_077274.3	Q96N66	MBOA7_HUMAN	membrane bound O-acyltransferase domain containing 7	429					phospholipid biosynthetic process	integral to membrane	acyltransferase activity			endometrium(4)|large_intestine(1)|lung(3)|prostate(1)|skin(1)	10	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					TACAGAAGTAGATGGAGGCCC	0.637000													42	60					0	0	1	0	0
ART3	419	broad.mit.edu	37	4	77003299	77003299	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr4:77003299A>G	ENST00000355810.4	+	3	511	c.392A>G	c.(391-393)tAt>tGt	p.Y131C	ART3_ENST00000349321.3_Missense_Mutation_p.Y131C|ART3_ENST00000513494.1_3'UTR|ART3_ENST00000341029.5_Missense_Mutation_p.Y131C	NM_001130016.2	NP_001123488.1	Q13508	NAR3_HUMAN	ADP-ribosyltransferase 3	131					protein ADP-ribosylation	anchored to membrane|integral to plasma membrane	NAD(P)+-protein-arginine ADP-ribosyltransferase activity|NAD+ ADP-ribosyltransferase activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)|stomach(1)	16			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			GATTATATCTATGGCTTCCAG	0.438000													15	53					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21229816	21229816	+	Silent	SNP	A	A	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:21229816A>G	ENST00000233242.1	-	26	10051	c.9924T>C	c.(9922-9924)caT>caC	p.H3308H		NM_000384.2	NP_000375	P04114	APOB_HUMAN	apolipoprotein B	3308					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TTCTAGGGACATGAAGGACTG	0.423000													33	57					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	215802251	215802251	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:215802251G>A	ENST00000366943.2	-	72	15882	c.15496C>T	c.(15496-15498)Cac>Tac	p.H5166Y	USH2A_ENST00000307340.3_Missense_Mutation_p.H5142Y			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	5142					maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ACGCTGCGGTGAAGAGAACCC	0.547000										HNSCC(13;0.011)			50	65					0	0	1	0	0
RAB3IP	117177	broad.mit.edu	37	12	70206605	70206605	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr12:70206605A>T	ENST00000550536.1	+	9	1683	c.1226A>T	c.(1225-1227)aAa>aTa	p.K409I	AC025263.3_ENST00000550437.1_Missense_Mutation_p.K34I|RAB3IP_ENST00000553099.1_Missense_Mutation_p.K187I|RAB3IP_ENST00000483530.2_Intron|RAB3IP_ENST00000362025.5_Intron|RAB3IP_ENST00000550847.1_Missense_Mutation_p.K100I|RAB3IP_ENST00000325555.9_Missense_Mutation_p.K187I|RAB3IP_ENST00000247833.7_Missense_Mutation_p.K393I|RAB3IP_ENST00000551641.1_Missense_Mutation_p.K187I	NM_001278402.1|NM_175623.2	NP_001265331.1|NP_783322.1	Q96QF0	RAB3I_HUMAN	RAB3A interacting protein	409					cilium assembly|Golgi to plasma membrane transport|protein localization to organelle|protein transport	actin cortical patch|centrosome|cytosol|lamellipodium|microtubule basal body|nucleus	guanyl-nucleotide exchange factor activity|protein binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	22	Esophageal squamous(21;0.187)		Lung(24;0.000381)|OV - Ovarian serous cystadenocarcinoma(12;0.00168)|STAD - Stomach adenocarcinoma(21;0.00694)			CACAGAATTAAATTAGGGGAC	0.333000													328	34					0	0	1	0	0
HORMAD1	84072	broad.mit.edu	37	1	150689644	150689644	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:150689644C>T	ENST00000368993.2	-	3	253	c.148G>A	c.(148-150)Gaa>Aaa	p.E50K	HORMAD1_ENST00000322343.7_Missense_Mutation_p.E50K|HORMAD1_ENST00000368995.4_5'UTR|HORMAD1_ENST00000361824.2_Missense_Mutation_p.E50K|HORMAD1_ENST00000476530.1_5'UTR			Q86X24	HORM1_HUMAN	HORMA domain containing 1	50	HORMA.				blastocyst development|cell differentiation|meiotic DNA double-strand break formation|meiotic recombination checkpoint|meiotic sister chromatid cohesion|mitosis|oogenesis|regulation of homologous chromosome segregation|spermatogenesis|synaptonemal complex assembly	chromosome|nucleus				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(3)|lung(4)|ovary(3)	16	all_cancers(9;3.23e-52)|all_epithelial(9;4.68e-43)|all_lung(15;5.74e-35)|Lung NSC(24;2.09e-31)|Breast(34;0.0009)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;2.32e-23)|all cancers(9;5.21e-23)|OV - Ovarian serous cystadenocarcinoma(6;6.72e-15)|BRCA - Breast invasive adenocarcinoma(12;0.000479)|LUSC - Lung squamous cell carcinoma(543;0.171)			TAAGCGCATTCTGGGAATATT	0.333000													21	340					0	0	1	0	0
C19orf45	374877	broad.mit.edu	37	19	7570984	7570984	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:7570984G>T	ENST00000361664.2	+	7	1281	c.1140G>T	c.(1138-1140)gaG>gaT	p.E380D		NM_198534.2	NP_940936.2	Q8NA69	CS045_HUMAN	chromosome 19 open reading frame 45	380										endometrium(1)|kidney(1)|liver(1)|lung(2)|ovary(2)|stomach(1)	8						GCCCTTCAGAGTGGAGACAGG	0.607000													21	20					5.35356e-11	5.65814e-11	1	1	0
SBF1	6305	broad.mit.edu	37	22	50885656	50885656	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr22:50885656C>T	ENST00000380817.3	-	41	5780	c.5597G>A	c.(5596-5598)cGt>cAt	p.R1866H	SBF1_ENST00000390679.3_Missense_Mutation_p.R1840H|SBF1_ENST00000348911.6_Missense_Mutation_p.R1841H	NM_002972.2	NP_002963.2	O95248	MTMR5_HUMAN	SET binding factor 1						protein dephosphorylation	integral to membrane|nucleus	protein tyrosine/serine/threonine phosphatase activity			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(8)|large_intestine(3)|lung(18)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	43		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)		GTAAACGCGACGCGTTGTCTT	0.672000													13	22					0	0	1	0	0
ASTN1	460	broad.mit.edu	37	1	176992702	176992702	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:176992702G>T	ENST00000367654.3	-	7	1487	c.1276C>A	c.(1276-1278)Cgc>Agc	p.R426S	ASTN1_ENST00000281881.3_5'UTR|ASTN1_ENST00000367657.3_Missense_Mutation_p.R426S|ASTN1_ENST00000361833.2_Missense_Mutation_p.R426S|ASTN1_ENST00000424564.2_Missense_Mutation_p.R426S	NM_004319.1	NP_004310.1	O14525	ASTN1_HUMAN	astrotactin 1						cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						AAGATGAAGCGGCTCCCTGCA	0.562000													6	22					8.12818e-05	8.34413e-05	1	1	0
POLQ	10721	broad.mit.edu	37	3	121228550	121228550	+	Splice_Site	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:121228550C>G	ENST00000264233.5	-	12	1945	c.1817G>C	c.(1816-1818)gGa>gCa	p.G606A		NM_199420.3	NP_955452.3	O75417	DPOLQ_HUMAN	polymerase (DNA directed), theta	606					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(55)|ovary(5)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	120				GBM - Glioblastoma multiforme(114;0.0915)		ATACACCTTTCCTGGTTTAGG	0.398000								DNA polymerases (catalytic subunits)					11	53					0	0	1	0	0
SPATA31E1	286234	broad.mit.edu	37	9	90500556	90500556	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr9:90500556G>A	ENST00000325643.5	+	4	1220	c.1154G>A	c.(1153-1155)cGg>cAg	p.R385Q		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1																		GAAAGAAAACGGGCCGACCAC	0.572000													12	58					0	0	1	0	0
RAB40AL	282808	broad.mit.edu	37	X	102192696	102192696	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chrX:102192696G>A	ENST00000218249.5	+	1	497	c.450G>A	c.(448-450)gtG>gtA	p.V150V		NM_001031834.1	NP_001027004.1	P0C0E4	RB40L_HUMAN	RAB40A, member RAS oncogene family-like	150					protein transport|small GTPase mediated signal transduction	mitochondrion|plasma membrane	GTP binding			endometrium(4)|large_intestine(2)|lung(3)|ovary(3)	12						GCCTGGGCGTGACCTTCTTTG	0.587000													27	40					0	0	1	0	0
PTPRO	5800	broad.mit.edu	37	12	15652490	15652490	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr12:15652490A>G	ENST00000281171.4	+	4	953	c.623A>G	c.(622-624)tAc>tGc	p.Y208C	PTPRO_ENST00000348962.2_Missense_Mutation_p.Y208C|PTPRO_ENST00000543886.1_Missense_Mutation_p.Y208C	NM_030667.2	NP_109592.1	Q16827	PTPRO_HUMAN	protein tyrosine phosphatase, receptor type, O	208	Fibronectin type-III 2.					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(2)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(11)|lung(30)|ovary(2)|prostate(1)|skin(17)|upper_aerodigestive_tract(1)	74		Hepatocellular(102;0.244)				CTTGTTGAGTACAGTGGTGTC	0.363000													26	60					0	0	1	0	0
GOLGA4	2803	broad.mit.edu	37	3	37367409	37367409	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:37367409G>A	ENST00000361924.2	+	14	4406	c.4032G>A	c.(4030-4032)ttG>ttA	p.L1344L	GOLGA4_ENST00000356847.4_Silent_p.L1366L|GOLGA4_ENST00000444882.1_Intron	NM_002078.4	NP_002069.2	Q13439	GOGA4_HUMAN	golgin A4	1344	Glu-rich.				Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding			NS(2)|breast(3)|central_nervous_system(3)|endometrium(6)|kidney(2)|large_intestine(17)|liver(2)|lung(16)|ovary(4)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	65						TAACACAGTTGAAGAAAGAGT	0.358000													6	16					0	0	1	0	0
CPSF3	51692	broad.mit.edu	37	2	9613060	9613060	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:9613060G>A	ENST00000460593.1	+	18	2996	c.1858G>A	c.(1858-1860)Gag>Aag	p.E620K	CPSF3_ENST00000238112.3_Missense_Mutation_p.E657K|CPSF3_ENST00000489403.1_3'UTR			Q9UKF6	CPSF3_HUMAN	cleavage and polyadenylation specific factor 3, 73kDa	657					histone mRNA 3'-end processing|mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex|ribonucleoprotein complex	5'-3' exonuclease activity|endoribonuclease activity|metal ion binding|protein binding|RNA binding			NS(1)|breast(3)|endometrium(1)|kidney(2)|large_intestine(5)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)	all_cancers(51;2.39e-25)|all_epithelial(98;8.75e-19)|Lung NSC(108;2.38e-06)|Ovarian(717;0.0308)		all cancers(51;2.2e-40)|Epithelial(75;6.71e-35)|OV - Ovarian serous cystadenocarcinoma(76;4.35e-21)|STAD - Stomach adenocarcinoma(1183;0.00644)		AGAATGTGAAGAGGGAAGTGA	0.418000													8	24					0	0	1	0	0
TKTL2	84076	broad.mit.edu	37	4	164394526	164394526	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr4:164394526C>G	ENST00000280605.3	-	1	521	c.361G>C	c.(361-363)Gtg>Ctg	p.V121L		NM_032136.4	NP_115512.3	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	121						cytoplasm	metal ion binding|transketolase activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(42)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	70	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				CCTGTTGCCACGTCAACAAAC	0.532000													22	49					0	0	1	0	0
CD27	939	broad.mit.edu	37	12	6559461	6559461	+	Missense_Mutation	SNP	C	C	T	rs150578547	byFrequency	TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr12:6559461C>T	ENST00000266557.3	+	3	620	c.391C>T	c.(391-393)Cgg>Tgg	p.R131W	CD27-AS1_ENST00000399492.2_RNA|CD27-AS1_ENST00000545339.1_RNA|CD27_ENST00000541233.1_3'UTR	NM_001242.4	NP_001233	P26842	CD27_HUMAN	CD27 molecule	131					anti-apoptosis|apoptosis|cell surface receptor linked signaling pathway|immunoglobulin mediated immune response|induction of apoptosis|positive regulation of B cell differentiation|positive regulation of JNK cascade|release of cytoplasmic sequestered NF-kappaB	extracellular region|integral to plasma membrane	caspase inhibitor activity|protein binding|transmembrane receptor activity	p.R131W(1)		kidney(1)|large_intestine(5)|lung(1)|urinary_tract(3)	10						GCTGACCGCTCGGTCGTCTCA	0.592000													9	67					0	0	1	0	0
GRIN2D	2906	broad.mit.edu	37	19	48908251	48908251	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:48908251G>A	ENST00000263269.3	+	3	814	c.726G>A	c.(724-726)caG>caA	p.Q242Q		NM_000836.2	NP_000827.2	O15399	NMDE4_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2D	242						cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|protein binding	p.Q242H(1)		autonomic_ganglia(1)|breast(6)|endometrium(2)|large_intestine(9)|lung(12)|ovary(5)|pancreas(1)|prostate(1)	37		all_epithelial(76;1.11e-06)|all_lung(116;5.79e-06)|Lung NSC(112;1.18e-05)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		all cancers(93;0.00014)|OV - Ovarian serous cystadenocarcinoma(262;0.000233)|Epithelial(262;0.0112)|GBM - Glioblastoma multiforme(486;0.0161)	L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Orphenadrine(DB01173)	TCAGCGCGCAGATCCGCCTGC	0.697000													14	53					0	0	1	0	0
TCHHL1	126637	broad.mit.edu	37	1	152059670	152059670	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:152059670G>T	ENST00000368806.1	-	3	552	c.488C>A	c.(487-489)gCc>gAc	p.A163D		NM_001008536.1	NP_001008536.1	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	163							calcium ion binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(1)|skin(7)|stomach(1)	60	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			GTGAGTCTTGGCTTCTCTCCA	0.448000													10	306					2.17888e-05	2.25112e-05	1	1	0
GSDMA	284110	broad.mit.edu	37	17	38121974	38121974	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr17:38121974G>A	ENST00000301659.4	+	2	152	c.34G>A	c.(34-36)Gcc>Acc	p.A12T		NM_178171.4	NP_835465.2	Q96QA5	GSDMA_HUMAN	gasdermin A	12					apoptosis|induction of apoptosis	perinuclear region of cytoplasm				NS(1)|endometrium(2)|large_intestine(3)|lung(1)	7						CCGGGCCCTGGCCAGACAGCT	0.587000													3	18					0	0	1	0	0
TCN1	6947	broad.mit.edu	37	11	59620726	59620726	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr11:59620726T>C	ENST00000257264.3	-	8	1294	c.1190A>G	c.(1189-1191)aAt>aGt	p.N397S		NM_001062.3	NP_001053.2	P20061	TCO1_HUMAN	transcobalamin I (vitamin B12 binding protein, R binder family)	397					cobalamin metabolic process|cobalamin transport|cobalt ion transport	extracellular region	cobalamin binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(15)|ovary(2)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29		all_epithelial(135;0.198)			Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GGTTCTGTCATTATTGTTGGC	0.493000													59	108					0	0	1	0	0
STPG2	285555	broad.mit.edu	37	4	99030392	99030392	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr4:99030392T>A	ENST00000295268.3	-	4	541	c.452A>T	c.(451-453)gAg>gTg	p.E151V		NM_174952.2	NP_777612.1			sperm-tail PG-rich repeat containing 2																		TTTAGGTAACTCTTGTCTTCC	0.318000													13	46					0	0	1	0	0
KDM5A	5927	broad.mit.edu	37	12	431614	431614	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr12:431614G>A	ENST00000399788.2	-	17	2757	c.2395C>T	c.(2395-2397)Cag>Tag	p.Q799*	KDM5A_ENST00000382815.4_Nonsense_Mutation_p.Q799*	NM_001042603.1	NP_001036068.1	P29375	KDM5A_HUMAN	lysine (K)-specific demethylase 5A	799					chromatin modification|multicellular organismal development|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(29)|ovary(1)|prostate(5)|skin(6)|stomach(1)|urinary_tract(2)	77						AGAAGCAGCTGAGCCACAGAA	0.398000			T	NUP98	AML								41	96					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13792266	13792266	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr5:13792266G>A	ENST00000265104.4	-	50	8389	c.8285C>T	c.(8284-8286)tCt>tTt	p.S2762F		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2762	AAA 3 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TTTTGTCACAGAATCTCTCAC	0.438000									Kartagener syndrome				13	79					0	0	1	0	0
DNAJA1	3301	broad.mit.edu	37	9	33026835	33026835	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr9:33026835G>A	ENST00000330899.4	+	3	340	c.157G>A	c.(157-159)Gaa>Aaa	p.E53K	DNAJA1_ENST00000544625.1_Intron|DNAJA1_ENST00000495015.1_Intron	NM_001539.2	NP_001530.1	P31689	DNJA1_HUMAN	DnaJ (Hsp40) homolog, subfamily A, member 1	53	J.				protein folding|response to heat|response to unfolded protein	membrane	ATP binding|heat shock protein binding|low-density lipoprotein particle receptor binding|metal ion binding|unfolded protein binding			large_intestine(2)|ovary(1)|skin(3)	6			LUSC - Lung squamous cell carcinoma(29;0.0227)	GBM - Glioblastoma multiforme(74;0.102)		TCAAGCTTACGAAGTTCTCTC	0.393000													15	101					0	0	1	0	0
TULP4	56995	broad.mit.edu	37	6	158870054	158870054	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr6:158870054G>A	ENST00000367097.3	+	4	1927	c.570G>A	c.(568-570)caG>caA	p.Q190Q	TULP4_ENST00000367094.2_Silent_p.Q190Q	NM_020245.4	NP_064630.2	Q9NRJ4	TULP4_HUMAN	tubby like protein 4	190					intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			endometrium(7)|kidney(2)|large_intestine(15)|lung(17)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)		CCGATGGGCAGGTGATTGTCA	0.587000													25	33					0	0	1	0	0
SULF2	55959	broad.mit.edu	37	20	46294038	46294038	+	Splice_Site	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr20:46294038C>T	ENST00000359930.4	-	14	2754		c.e14-1		SULF2_ENST00000361612.4_Splice_Site|SULF2_ENST00000484875.1_Splice_Site|SULF2_ENST00000467815.1_Splice_Site	NM_018837.3	NP_061325.1	Q8IWU5	SULF2_HUMAN	sulfatase 2						bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	54						GGGTTTCAATCTGAGGGAGGG	0.527000													41	102					0	0	1	0	0
ZNF589	51385	broad.mit.edu	37	3	48309864	48309864	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:48309864C>T	ENST00000354698.3	+	4	755	c.683C>T	c.(682-684)tCa>tTa	p.S228L	ZNF589_ENST00000427617.2_Intron|ZNF589_ENST00000412564.1_Intron|ZNF589_ENST00000440261.2_Intron	NM_016089.2	NP_057173.2	Q86UQ0	ZN589_HUMAN	zinc finger protein 589	228					regulation of transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)|skin(1)	4				BRCA - Breast invasive adenocarcinoma(193;0.000649)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		AACCAGAAGTCAAACCTGTTC	0.502000													29	77					0	0	1	0	0
PLB1	151056	broad.mit.edu	37	2	28840617	28840617	+	Silent	SNP	T	T	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:28840617T>C	ENST00000422425.2	+	44	3230	c.3186T>C	c.(3184-3186)tgT>tgC	p.C1062C	PLB1_ENST00000541605.1_Silent_p.C38C|PLB1_ENST00000327757.5_Silent_p.C1073C	NM_001170585.1	NP_001164056.1	Q6P1J6	PLB1_HUMAN	phospholipase B1	1073	4 X 308-326 AA approximate repeats.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(31)|ovary(6)|prostate(1)|skin(7)|stomach(2)	69	Acute lymphoblastic leukemia(172;0.155)					ACTTCCTGTGTACAGAGTGGA	0.473000													22	75					0	0	1	0	0
ZNF573	126231	broad.mit.edu	37	19	38231070	38231070	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:38231070G>A	ENST00000339503.4	-	8	648	c.147C>T	c.(145-147)atC>atT	p.I49I	ZNF573_ENST00000590414.2_Silent_p.I107I|ZNF573_ENST00000357309.3_Silent_p.I19I|ZNF573_ENST00000585724.1_3'UTR|ZNF573_ENST00000392138.1_Silent_p.I20I|ZNF573_ENST00000536220.1_Silent_p.I19I	NM_152360.3	NP_689573.3	Q86YE8	ZN573_HUMAN	zinc finger protein 573	87	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|cervix(3)|endometrium(2)|large_intestine(8)|liver(1)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)|Lung(45;0.0813)|LUSC - Lung squamous cell carcinoma(53;0.146)			CTATGTAGCTGATTATCTCAC	0.313000													5	18					0	0	1	0	0
ISLR2	57611	broad.mit.edu	37	15	74426445	74426445	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr15:74426445C>T	ENST00000361742.3	+	4	2119	c.1350C>T	c.(1348-1350)ctC>ctT	p.L450L	ISLR2_ENST00000435464.1_Silent_p.L450L|ISLR2_ENST00000565540.1_Silent_p.L450L|ISLR2_ENST00000453268.2_Silent_p.L450L|ISLR2_ENST00000419208.1_Silent_p.L450L|ISLR2_ENST00000445793.1_Silent_p.L450L|ISLR2_ENST00000561975.1_Intron|ISLR2_ENST00000565159.1_Silent_p.L450L	NM_001130136.1|NM_020851.2	NP_001123608.1|NP_065902.1	Q6UXK2	ISLR2_HUMAN	immunoglobulin superfamily containing leucine-rich repeat 2	450					positive regulation of axon extension	cell surface|integral to membrane|plasma membrane				breast(3)|endometrium(6)|large_intestine(7)|lung(17)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	36						ACCAGATCCTCGCGGACCCGG	0.642000													7	9					0	0	1	0	0
DNTT	1791	broad.mit.edu	37	10	98078233	98078233	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr10:98078233T>C	ENST00000419175.1	+	2	498	c.328T>C	c.(328-330)Tgc>Cgc	p.C110R	DNTT_ENST00000371174.2_Missense_Mutation_p.C110R	NM_001017520.1|NM_004088.3	NP_001017520.1|NP_004079.3	P04053	TDT_HUMAN	DNA nucleotidylexotransferase	110	BRCT.				DNA modification	nucleus	DNA binding|DNA nucleotidylexotransferase activity|DNA-directed DNA polymerase activity|metal ion binding			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(6)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	27		Colorectal(252;0.0815)|all_hematologic(284;0.224)		Epithelial(162;7.97e-08)|all cancers(201;1.89e-06)		GCTGATCGAATGCATAAGAGC	0.468000													26	77					0	0	1	0	0
TMEM245	23731	broad.mit.edu	37	9	111853209	111853209	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr9:111853209C>T	ENST00000374586.3	-	5	1174	c.1143G>A	c.(1141-1143)ccG>ccA	p.P381P		NM_032012.3	NP_114401.2	Q9H330	CI005_HUMAN	transmembrane protein 245	381						integral to membrane											GACCTGCAATCGGCACTGGCA	0.378000													5	35					0	0	1	0	0
CHFR	55743	broad.mit.edu	37	12	133454175	133454175	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr12:133454175C>T	ENST00000266880.7	-	3	262	c.199G>A	c.(199-201)Gaa>Aaa	p.E67K	CHFR_ENST00000450056.2_Missense_Mutation_p.E67K|CHFR_ENST00000315585.7_Missense_Mutation_p.E67K|CHFR_ENST00000541837.2_5'UTR|CHFR_ENST00000432561.2_Missense_Mutation_p.E67K|CHFR_ENST00000443047.2_Missense_Mutation_p.E67K			Q96EP1	CHFR_HUMAN	checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase	67	FHA.				cell division|mitosis|mitotic cell cycle checkpoint|modification-dependent protein catabolic process|protein polyubiquitination	PML body	nucleotide binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;0.00552)|all_epithelial(31;0.226)		OV - Ovarian serous cystadenocarcinoma(86;2.59e-08)|Epithelial(86;6.38e-07)|all cancers(50;1.56e-05)		CCTGATTTTTCATCCACTACA	0.448000													31	52					0	0	1	0	0
IZUMO1	284359	broad.mit.edu	37	19	49245113	49245113	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:49245113G>A	ENST00000332955.2	-	8	1234	c.687C>T	c.(685-687)ggC>ggT	p.G229G		NM_182575.2	NP_872381.2	Q8IYV9	IZUM1_HUMAN	izumo sperm-egg fusion 1	229	Ig-like C2-type.				fusion of sperm to egg plasma membrane	integral to membrane				endometrium(4)|kidney(3)|large_intestine(4)|lung(2)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	17		all_lung(116;0.000156)|Lung NSC(112;0.000251)|all_epithelial(76;0.000761)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000348)|Epithelial(262;0.019)|GBM - Glioblastoma multiforme(486;0.022)		AGCGGTAGCTGCCTGCATCCT	0.572000													21	56					0	0	1	0	0
ANKRD37	353322	broad.mit.edu	37	4	186318345	186318345	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr4:186318345C>T	ENST00000335174.4	+	2	509	c.69C>T	c.(67-69)gtC>gtT	p.V23V	ANKRD37_ENST00000507479.1_3'UTR	NM_181726.2	NP_859077.1	Q7Z713	ANR37_HUMAN	ankyrin repeat domain 37	23						cytoplasm|nucleus				NS(1)|large_intestine(1)|lung(1)	3		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;0.00109)|Colorectal(36;0.0215)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;1.27e-25)|Epithelial(43;1.02e-22)|OV - Ovarian serous cystadenocarcinoma(60;1.14e-11)|BRCA - Breast invasive adenocarcinoma(30;7.72e-05)|GBM - Glioblastoma multiforme(59;0.000118)|STAD - Stomach adenocarcinoma(60;0.000756)|LUSC - Lung squamous cell carcinoma(40;0.00902)|COAD - Colon adenocarcinoma(29;0.00939)|READ - Rectum adenocarcinoma(43;0.155)		GGGCCTCGGTCAACGCACCCC	0.622000													13	33					0	0	1	0	0
TAS2R46	259292	broad.mit.edu	37	12	11213998	11213998	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr12:11213998T>A	ENST00000533467.1	-	1	895	c.896A>T	c.(895-897)tAc>tTc	p.Y299F	PRR4_ENST00000536668.1_Intron|TAS2R14_ENST00000381852.4_Intron	NM_176887.2	NP_795368.2	P59540	T2R46_HUMAN	taste receptor, type 2, member 46	299					sensory perception of taste	cilium membrane|integral to membrane	G-protein coupled receptor activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	12			OV - Ovarian serous cystadenocarcinoma(49;0.0344)	BRCA - Breast invasive adenocarcinoma(232;0.196)		TTTCACCCAGTACCTCACATG	0.398000													36	87					0	0	1	0	0
TMEM230	29058	broad.mit.edu	37	20	5081551	5081551	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr20:5081551C>T	ENST00000379286.2	-	5	669	c.249G>A	c.(247-249)ctG>ctA	p.L83L	TMEM230_ENST00000492419.1_5'UTR|TMEM230_ENST00000379279.2_Silent_p.L83L|TMEM230_ENST00000379283.2_Silent_p.L83L|TMEM230_ENST00000379277.2_Silent_p.L83L|TMEM230_ENST00000202834.7_Silent_p.L83L|TMEM230_ENST00000342308.5_Silent_p.L146L	NM_001009924.1	NP_001009924.1	Q96A57	CT030_HUMAN	transmembrane protein 230	83						integral to membrane											TGCCAATGATCAGCACTGGAA	0.483000											OREG0025754	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	57					0	0	1	0	0
NEK11	79858	broad.mit.edu	37	3	130889624	130889624	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:130889624A>T	ENST00000383366.4	+	14	1585	c.1292A>T	c.(1291-1293)gAt>gTt	p.D431V	NEK11_ENST00000507910.1_Missense_Mutation_p.D431V|NEK11_ENST00000356918.4_Missense_Mutation_p.D431V|NEK11_ENST00000510769.1_Missense_Mutation_p.D326V|NEK11_ENST00000510688.1_Missense_Mutation_p.D431V|NEK11_ENST00000412440.2_Missense_Mutation_p.D247V|NEK11_ENST00000511262.1_Missense_Mutation_p.D431V|NEK11_ENST00000429253.2_Missense_Mutation_p.D431V|NEK11_ENST00000508196.1_Missense_Mutation_p.D431V	NM_024800.4	NP_079076.3	Q8NG66	NEK11_HUMAN	NIMA-related kinase 11	431					cell cycle|intra-S DNA damage checkpoint|intracellular protein kinase cascade	nucleolus	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(8)|lung(14)|stomach(1)|urinary_tract(2)	33						AAGGAATCTGATGAACCAACT	0.393000													35	159					0	0	1	0	0
SMARCA2	6595	broad.mit.edu	37	9	2033021	2033021	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr9:2033021A>G	ENST00000382203.1	+	3	504	c.295A>G	c.(295-297)Atg>Gtg	p.M99V	SMARCA2_ENST00000382194.1_Missense_Mutation_p.M99V|SMARCA2_ENST00000357248.2_Missense_Mutation_p.M99V|SMARCA2_ENST00000349721.2_Missense_Mutation_p.M99V|SMARCA2_ENST00000491574.1_3'UTR			P51531	SMCA2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	99					chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		GGGCACTGGTATGCGACCACC	0.507000													90	90					0	0	1	0	0
LOC401127	401127	broad.mit.edu	37	4	39483091	39483091	+	RNA	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr4:39483091C>T	ENST00000513652.1	+	0	1098																											TGTTAAGTCCCTTTGCTCCCA	0.512000													17	32					0	0	1	0	0
CACNG5	27091	broad.mit.edu	37	17	64873438	64873438	+	Translation_Start_Site	SNP	A	A	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr17:64873438A>T	ENST00000533854.1	+	0	225							Q9UF02	CCG5_HUMAN	calcium channel, voltage-dependent, gamma subunit 5						regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|postsynaptic density|postsynaptic membrane	voltage-gated calcium channel activity			NS(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(6)|pancreas(1)|prostate(1)|skin(2)	24			BRCA - Breast invasive adenocarcinoma(6;1.61e-08)			TTGCACAGCAACGGTCCAGGA	0.632000													25	25					0	0	1	0	0
ARHGEF12	23365	broad.mit.edu	37	11	120312888	120312888	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr11:120312888C>T	ENST00000397843.2	+	15	1445	c.1279C>T	c.(1279-1281)Cag>Tag	p.Q427*	ARHGEF12_ENST00000532993.1_Nonsense_Mutation_p.Q324*|ARHGEF12_ENST00000356641.3_Nonsense_Mutation_p.Q408*	NM_015313.2	NP_056128.1	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12	427	RGSL.				apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(5)|endometrium(6)|kidney(5)|large_intestine(13)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(2)	61		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)		TGAGTTTCATCAGTTCTTTCT	0.388000			T	MLL	AML								5	22					0	0	1	0	0
KDELC1	79070	broad.mit.edu	37	13	103443624	103443624	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr13:103443624G>C	ENST00000376004.4	-	5	1165	c.829C>G	c.(829-831)Ctg>Gtg	p.L277V	KDELC1_ENST00000460338.1_5'UTR	NM_024089.2	NP_076994.2	Q6UW63	KDEL1_HUMAN	KDEL (Lys-Asp-Glu-Leu) containing 1	277						endoplasmic reticulum lumen				central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|skin(1)	19	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					ATGGTTTCCAGAACAGAATCA	0.443000													97	179					0	0	1	0	0
SLC8A2	6543	broad.mit.edu	37	19	47969402	47969402	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:47969402A>T	ENST00000236877.6	-	2	654	c.259T>A	c.(259-261)Tcc>Acc	p.S87T	SLC8A2_ENST00000539381.1_Intron|SLC8A2_ENST00000542837.1_Intron	NM_015063.2	NP_055878.1	Q9UPR5	NAC2_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 2	87					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(2)|prostate(2)|skin(5)|stomach(1)	31		all_cancers(25;3.05e-07)|all_lung(116;4.19e-06)|Lung NSC(112;7.16e-06)|all_epithelial(76;7.65e-06)|all_neural(266;0.0652)|Ovarian(192;0.086)|Breast(70;0.173)		OV - Ovarian serous cystadenocarcinoma(262;0.000501)|all cancers(93;0.00058)|Epithelial(262;0.0181)|GBM - Glioblastoma multiforme(486;0.0457)		GCGATGATGGACACTCCCAGA	0.607000													51	75					0	0	1	0	0
RUFY3	22902	broad.mit.edu	37	4	71588247	71588247	+	Translation_Start_Site	SNP	T	T	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr4:71588247T>A	ENST00000226328.4	+	0	520				RUFY3_ENST00000417478.2_Intron|RUFY3_ENST00000381006.3_De_novo_Start_OutOfFrame	NM_014961.3	NP_055776.1	Q7L099	RUFY3_HUMAN	RUN and FYVE domain containing 3						negative regulation of axonogenesis	filopodium|growth cone				endometrium(1)|kidney(3)|large_intestine(4)|lung(6)|prostate(1)|stomach(1)	16		all_hematologic(202;0.248)	Lung(101;0.235)			tgtgtgtgagtgtgtgtgtgt	0.478000													3	22					0	0	1	0	0
COX15	1355	broad.mit.edu	37	10	101486767	101486767	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr10:101486767C>G	ENST00000370483.5	-	4	590	c.540G>C	c.(538-540)atG>atC	p.M180I	CUTC_ENST00000493385.1_Intron|COX15_ENST00000016171.5_Missense_Mutation_p.M180I	NM_004376.5|NM_078470.4	NP_004367.2|NP_510870.1	Q7KZN9	COX15_HUMAN	cytochrome c oxidase assembly homolog 15 (yeast)	180					heme a biosynthetic process|respiratory chain complex IV assembly|respiratory gaseous exchange	integral to membrane|mitochondrial respiratory chain	cytochrome-c oxidase activity			endometrium(1)|kidney(1)|large_intestine(4)|liver(1)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	13		Colorectal(252;0.234)		Epithelial(162;3.08e-10)|all cancers(201;2.43e-08)		CACGTCCTTTCATGCCACGGC	0.527000													12	36					0	0	1	0	0
LOC101929006	101929006	broad.mit.edu	37	6	29230615	29230615	+	RNA	SNP	G	G	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr6:29230615G>T	ENST00000441381.1	+	0	79																											ATACCACAATGAGATGGGAGA	0.413000													50	32					6.03219e-31	6.56944e-31	1	1	0
TCTN2	79867	broad.mit.edu	37	12	124155812	124155812	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr12:124155812C>G	ENST00000303372.5	+	1	153	c.25C>G	c.(25-27)Ctt>Gtt	p.L9V	TCTN2_ENST00000426174.2_Missense_Mutation_p.L9V	NM_001143850.2|NM_024809.4	NP_001137322.1|NP_079085.2	Q96GX1	TECT2_HUMAN	tectonic family member 2	9					cilium assembly|smoothened signaling pathway	integral to membrane				breast(2)|cervix(2)|endometrium(4)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	30	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000163)|Epithelial(86;0.000502)|all cancers(50;0.00451)		TCCGGCCGCTCTTCTTTTGAG	0.642000													3	20					0	0	1	0	0
TSSK3	81629	broad.mit.edu	37	1	32828358	32828358	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:32828358G>C	ENST00000373534.3	+	1	561	c.56G>C	c.(55-57)gGg>gCg	p.G19A	FAM229A_ENST00000415596.1_Intron	NM_052841.3	NP_443073.1	Q96PN8	TSSK3_HUMAN	testis-specific serine kinase 3	19	Protein kinase.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|large_intestine(6)|lung(5)|skin(2)|stomach(1)	15		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.17)|Breast(348;0.212)				ATTGGGGAAGGGACCTACTCA	0.507000													27	80					0	0	1	0	0
OTOGL	283310	broad.mit.edu	37	12	80732942	80732942	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr12:80732942A>G	ENST00000458043.2	+	42	4927	c.4921A>G	c.(4921-4923)Act>Gct	p.T1641A	OTOGL_ENST00000547103.1_Missense_Mutation_p.T1629A	NM_173591.3	NP_775862.3			otogelin-like											breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						TGTAATTACTACTCCAGCTGG	0.393000													39	58					0	0	1	0	0
MIOS	54468	broad.mit.edu	37	7	7628192	7628192	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr7:7628192C>G	ENST00000340080.4	+	8	2303	c.1882C>G	c.(1882-1884)Cag>Gag	p.Q628E	MIOS_ENST00000405785.1_Missense_Mutation_p.Q628E	NM_019005.3	NP_061878.3	Q9NXC5	MIO_HUMAN	missing oocyte, meiosis regulator, homolog (Drosophila)	628										breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(15)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						TAGTGATACTCAGGTGAAAAC	0.318000													4	30					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179480041	179480041	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:179480041C>T	ENST00000589042.1	-	259	48855	c.48631G>A	c.(48631-48633)Gaa>Aaa	p.E16211K	TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E7146K|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E7271K|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E7338K|TTN_ENST00000591111.1_Missense_Mutation_p.E14570K|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.E13643K|TTN-AS1_ENST00000589830.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	14570	Fibronectin type-III 17.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TACTTTGTTTCTGCAACAGGT	0.373000													9	32					0	0	1	0	0
HGFAC	3083	broad.mit.edu	37	4	3451116	3451116	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr4:3451116G>A	ENST00000382774.3	+	14	2053	c.1938G>A	c.(1936-1938)cgG>cgA	p.R646R	HGFAC_ENST00000511533.1_Silent_p.R653R	NM_001528.2	NP_001519.1	Q04756	HGFA_HUMAN	HGF activator	646	Peptidase S1.				proteolysis	extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|large_intestine(2)|lung(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	22				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		ACCGGATACGGCCTCCCAGGC	0.622000													13	24					0	0	1	0	0
DDX52	11056	broad.mit.edu	37	17	35988702	35988702	+	Silent	SNP	T	T	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr17:35988702T>C	ENST00000349699.2	-	6	805	c.762A>G	c.(760-762)ttA>ttG	p.L254L	DDX52_ENST00000394367.3_Silent_p.L146L	NM_007010.3	NP_008941.2	Q9Y2R4	DDX52_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 52	254	Helicase ATP-binding.					nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			biliary_tract(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(5)|ovary(1)|skin(3)	17		Breast(25;0.00637)|Ovarian(249;0.15)				AAATTTTTATTAACTCTCTGT	0.313000													28	32					0	0	1	0	0
UGT1A1	54658	broad.mit.edu	37	2	234676951	234676951	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:234676951G>A	ENST00000360418.3	+	4	1170	c.1170G>A	c.(1168-1170)atG>atA	p.M390I	UGT1A6_ENST00000373424.1_Missense_Mutation_p.M122I|UGT1A10_ENST00000373445.1_Missense_Mutation_p.M387I|UGT1A1_ENST00000609767.1_Missense_Mutation_p.M391I|UGT1A8_ENST00000305208.5_Missense_Mutation_p.M390I|UGT1A5_ENST00000373414.3_Missense_Mutation_p.M391I|UGT1A6_ENST00000406651.1_Missense_Mutation_p.M122I|UGT1A9_ENST00000354728.4_Missense_Mutation_p.M387I|UGT1A7_ENST00000373426.3_Missense_Mutation_p.M387I|UGT1A1_ENST00000609637.1_Missense_Mutation_p.M387I|UGT1A1_ENST00000373450.4_Missense_Mutation_p.M387I|UGT1A4_ENST00000373409.3_Missense_Mutation_p.M391I|UGT1A1_ENST00000608381.1_Missense_Mutation_p.M391I|UGT1A1_ENST00000608383.1_Missense_Mutation_p.M390I|UGT1A10_ENST00000344644.5_Missense_Mutation_p.M387I|UGT1A6_ENST00000305139.6_Missense_Mutation_p.M389I|UGT1A3_ENST00000482026.1_Missense_Mutation_p.M391I			P22309	UD11_HUMAN		390					bilirubin conjugation|digestion|estrogen metabolic process|flavone metabolic process|heme catabolic process	endoplasmic reticulum membrane|microsome	enzyme binding|enzyme inhibitor activity|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding|steroid binding			breast(1)|central_nervous_system(2)|endometrium(7)|large_intestine(5)|lung(9)|skin(4)|urinary_tract(2)	30		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;4.1e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000435)|Lung(119;0.00211)|LUSC - Lung squamous cell carcinoma(224;0.0054)	Abacavir(DB01048)|Adenine(DB00173)|Diclofenac(DB00586)|Estradiol(DB00783)|Ezetimibe(DB00973)|Irinotecan(DB00762)|Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|Propofol(DB00818)|Rifampin(DB01045)|Troglitazone(DB00197)	CCATGGTGATGATGCCCTTGT	0.473000													33	54					0	0	1	0	0
RGL3	57139	broad.mit.edu	37	19	11527324	11527324	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:11527324G>T	ENST00000380456.3	-	4	452	c.389C>A	c.(388-390)aCa>aAa	p.T130K	RGL3_ENST00000393423.3_Missense_Mutation_p.T130K	NM_001035223.2|NM_001161616.1	NP_001030300.2|NP_001155088.1	Q3MIN7	RGL3_HUMAN	ral guanine nucleotide dissociation stimulator-like 3	130	N-terminal Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular				breast(1)|endometrium(4)|large_intestine(2)|lung(9)|ovary(1)|skin(1)	18						TTGTACCGCTGTCTTCTTGAT	0.557000													26	104					8.58068e-18	9.23044e-18	1	1	0
XIRP2	129446	broad.mit.edu	37	2	168115691	168115691	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:168115691G>C	ENST00000409728.1	+	11	2823	c.2734G>C	c.(2734-2736)Gat>Cat	p.D912H	XIRP2_ENST00000409605.1_Missense_Mutation_p.D657H|XIRP2_ENST00000420519.1_Missense_Mutation_p.D912H|XIRP2_ENST00000409043.1_Missense_Mutation_p.D879H|XIRP2_ENST00000409273.1_3'UTR|XIRP2_ENST00000409195.1_3'UTR|XIRP2_ENST00000409756.2_Missense_Mutation_p.D879H|XIRP2_ENST00000295237.9_3'UTR	NM_001199143.1	NP_001186072.1	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	0					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						ATTTGGAAAGGATGTTAAACC	0.343000													14	27					0	0	1	0	0
DHX57	90957	broad.mit.edu	37	2	39055503	39055503	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:39055503A>G	ENST00000295373.6	-	14	2744	c.2618T>C	c.(2617-2619)tTc>tCc	p.F873S		NM_198963.1	NP_945314.1	Q6P158	DHX57_HUMAN	DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57	873	Helicase C-terminal.						ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(9)|kidney(2)|large_intestine(15)|lung(20)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	62		all_hematologic(82;0.248)				TCTGTTGTTGAAAAGAGAATT	0.343000													8	28					0	0	1	0	0
NPIPB6	728741	broad.mit.edu	37	16	28354377	28354377	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr16:28354377T>C	ENST00000532254.1	-	7	1514	c.829A>G	c.(829-831)Aac>Gac	p.N277D	NPIPB6_ENST00000533640.1_Missense_Mutation_p.N259D	NM_001282524.1	NP_001269453.1			nuclear pore complex interacting protein family, member B6																		CTCAGGGAGTTATCAGTTATA	0.502000													5	94					0	0	1	0	0
PRDM4	11108	broad.mit.edu	37	12	108145930	108145930	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr12:108145930T>C	ENST00000228437.5	-	5	847	c.388A>G	c.(388-390)Ata>Gta	p.I130V	RP11-864J10.4_ENST00000546714.1_RNA	NM_012406.3	NP_036538.3	Q9UKN5	PRDM4_HUMAN	PR domain containing 4	130					cell proliferation|negative regulation of cell cycle|nerve growth factor receptor signaling pathway|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			biliary_tract(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(6)|prostate(2)|skin(2)|urinary_tract(1)	20						TCAACATTTATAGAGTTAGGG	0.378000													18	69					0	0	1	0	0
TRPC6	7225	broad.mit.edu	37	11	101341920	101341920	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr11:101341920C>T	ENST00000344327.3	-	9	2827	c.2403G>A	c.(2401-2403)atG>atA	p.M801I	TRPC6_ENST00000532133.1_Missense_Mutation_p.M723I|TRPC6_ENST00000348423.4_Missense_Mutation_p.M685I|TRPC6_ENST00000360497.4_Missense_Mutation_p.M746I	NM_004621.5	NP_004612.2	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel, subfamily C, member 6	801					axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(14)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		TTACCTTGTTCATCTCTGCAT	0.378000													33	73					0	0	1	0	0
SETX	23064	broad.mit.edu	37	9	135176041	135176041	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr9:135176041G>A	ENST00000372169.2	-	12	5706	c.5524C>T	c.(5524-5526)Cat>Tat	p.H1842Y	SETX_ENST00000393220.1_Missense_Mutation_p.H1842Y|SETX_ENST00000224140.5_Missense_Mutation_p.H1842Y			Q7Z333	SETX_HUMAN	senataxin	1842					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(1)|lung(36)|ovary(2)|prostate(2)|skin(1)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	97		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		CGAAATTTATGAACATAACCA	0.353000													16	83					0	0	1	0	0
ABL2	27	broad.mit.edu	37	1	179077197	179077197	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:179077197G>C	ENST00000502732.1	-	12	3408	c.3205C>G	c.(3205-3207)Ctg>Gtg	p.L1069V	ABL2_ENST00000507173.1_Missense_Mutation_p.L945V|ABL2_ENST00000512653.1_Missense_Mutation_p.L1054V|ABL2_ENST00000511413.1_Missense_Mutation_p.L966V|ABL2_ENST00000344730.3_Missense_Mutation_p.L951V|ABL2_ENST00000504405.1_Missense_Mutation_p.L930V|ABL2_ENST00000408940.3_Missense_Mutation_p.L1033V|ABL2_ENST00000367623.4_Missense_Mutation_p.L1048V	NM_001168236.1|NM_001168237.1|NM_001168238.1|NM_007314.3	NP_001161708.1|NP_001161709.1|NP_001161710.1|NP_009298.1	P42684	ABL2_HUMAN	c-abl oncogene 2, non-receptor tyrosine kinase	1069	F-actin-binding (By similarity).				axon guidance|cell adhesion|peptidyl-tyrosine phosphorylation|positive regulation of oxidoreductase activity|signal transduction	cytoskeleton|cytosol	ATP binding|magnesium ion binding|manganese ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(8)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	65					Adenosine triphosphate(DB00171)|Dasatinib(DB01254)	GTTTTTCTCAGAGCCACTTTA	0.537000			T	ETV6	AML								25	59					0	0	1	0	0
ITPKB	3707	broad.mit.edu	37	1	226923413	226923413	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:226923413C>T	ENST00000429204.1	-	2	2074	c.1747G>A	c.(1747-1749)Gag>Aag	p.E583K	ITPKB_ENST00000366784.1_Missense_Mutation_p.E583K|ITPKB_ENST00000272117.3_Missense_Mutation_p.E583K	NM_002221.3	NP_002212.3	P27987	IP3KB_HUMAN	inositol-trisphosphate 3-kinase B	583							ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity			central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(13)|ovary(4)|prostate(1)|skin(1)	30		Prostate(94;0.0773)				TGCGTCTCCTCCAAGGCCCCA	0.602000													19	17					0	0	1	0	0
ATP8B5P	158381	broad.mit.edu	37	9	35450008	35450008	+	RNA	SNP	G	G	A	rs141566883	by1000genomes	TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr9:35450008G>A	ENST00000430846.1	+	0	2858																											TATCAAATCAGTCACTTTTAT	0.428000													39	169					0	0	1	0	0
BTAF1	9044	broad.mit.edu	37	10	93723860	93723860	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr10:93723860G>C	ENST00000265990.6	+	13	1739	c.1431G>C	c.(1429-1431)tgG>tgC	p.W477C	BTAF1_ENST00000471217.1_3'UTR	NM_003972.2	NP_003963.1	O14981	BTAF1_HUMAN	BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa	477					negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(2)|urinary_tract(6)	59		Colorectal(252;0.0846)				ATACATTGTGGGATGCTCTTC	0.368000													19	26					0	0	1	0	0
FAM91A1	157769	broad.mit.edu	37	8	124787454	124787454	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr8:124787454C>T	ENST00000334705.7	+	3	471	c.225C>T	c.(223-225)ctC>ctT	p.L75L	FAM91A1_ENST00000521166.1_Silent_p.L75L	NM_144963.2	NP_659400	Q658Y4	F91A1_HUMAN	family with sequence similarity 91, member A1	75										breast(4)|central_nervous_system(3)|endometrium(6)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	28	Lung NSC(37;8.76e-13)|Ovarian(258;0.00744)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00192)			GAGATCATCTCATGCTGTACC	0.388000													19	42					0	0	1	0	0
OXCT1	5019	broad.mit.edu	37	5	41762297	41762297	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr5:41762297C>T	ENST00000196371.5	-	14	1414	c.1254G>A	c.(1252-1254)aaG>aaA	p.K418K	OXCT1_ENST00000513081.1_5'UTR|OXCT1_ENST00000509987.1_Silent_p.K232K|OXCT1_ENST00000512084.1_Silent_p.K21K|OXCT1_ENST00000510634.1_Silent_p.K21K	NM_000436.3	NP_000427.1	P55809	SCOT1_HUMAN	3-oxoacid CoA transferase 1	418					cellular lipid metabolic process|ketone body catabolic process	mitochondrial matrix	3-oxoacid CoA-transferase activity|protein homodimerization activity	p.K418N(1)		breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(1)|skin(2)	28					Succinic acid(DB00139)	CTTTCACCATCTTCCCCTGCA	0.383000													57	64					0	0	1	0	0
MET	4233	broad.mit.edu	37	7	116340201	116340201	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr7:116340201G>A	ENST00000397752.3	+	2	1263	c.1063G>A	c.(1063-1065)Gaa>Aaa	p.E355K	MET_ENST00000436117.2_Missense_Mutation_p.E355K|MET_ENST00000318493.6_Missense_Mutation_p.E355K	NM_000245.2|NM_001127500.1	NP_000236.2|NP_001120972.1	P08581	MET_HUMAN	met proto-oncogene	355	Sema.				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			NS(10)|breast(4)|central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(5)|kidney(25)|large_intestine(8)|liver(3)|lung(70)|ovary(10)|pleura(2)|prostate(4)|skin(5)|stomach(6)|testis(1)|thyroid(4)|upper_aerodigestive_tract(64)|urinary_tract(3)	233	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			AGATTCTGCCGAACCAATGGA	0.473000			Mis		"""papillary renal, head-neck squamous cell """	papillary renal			Hereditary Papillary Renal Carcinoma (type 1)				14	31					0	0	1	0	0
MYO3A	53904	broad.mit.edu	37	10	26462887	26462887	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr10:26462887A>C	ENST00000265944.5	+	30	3860	c.3694A>C	c.(3694-3696)Aaa>Caa	p.K1232Q	MYO3A_ENST00000543632.1_Intron	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	1232					protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						GAAAGTGGAGAAAGAGGAAGC	0.433000													10	36					0	0	1	0	0
IKBKB	3551	broad.mit.edu	37	8	42177104	42177104	+	Splice_Site	SNP	A	A	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr8:42177104A>G	ENST00000520810.1	+	15	1704	c.1518A>G	c.(1516-1518)acA>acG	p.T506T	IKBKB_ENST00000522785.1_Intron|IKBKB_ENST00000520835.1_Splice_Site_p.T504T|IKBKB_ENST00000416505.2_Splice_Site_p.T447T|IKBKB_ENST00000379708.3_Splice_Site_p.T283T|IKBKB_ENST00000522147.1_Intron	NM_001556.2	NP_001547.1	O14920	IKKB_HUMAN	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	506					anti-apoptosis|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|membrane raft	ATP binding|identical protein binding|IkappaB kinase activity			breast(4)|lung(1)|ovary(2)|skin(1)	8	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;6.21e-12)|Lung NSC(13;1.04e-10)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;1.37e-10)|Colorectal(10;0.00102)|OV - Ovarian serous cystadenocarcinoma(14;0.00168)|Lung(22;0.00467)|LUSC - Lung squamous cell carcinoma(45;0.024)|COAD - Colon adenocarcinoma(11;0.0264)		Arsenic trioxide(DB01169)|Auranofin(DB00995)	TTTTTTCAGCATCAGATAAAC	0.408000											OREG0018747	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	10					0	0	1	0	0
RNF17	56163	broad.mit.edu	37	13	25419126	25419126	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr13:25419126C>G	ENST00000255324.5	+	22	3062	c.3010C>G	c.(3010-3012)Cta>Gta	p.L1004V	RNF17_ENST00000381921.1_Missense_Mutation_p.L1004V|RNF17_ENST00000339524.3_Missense_Mutation_p.L56V	NM_001184993.1|NM_031277.2	NP_001171922.1|NP_112567.2	Q9BXT8	RNF17_HUMAN	ring finger protein 17	1004	Tudor 2.				multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			NS(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(15)|ovary(1)|prostate(3)|skin(6)	36		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		GGGTGTTGAACTAGTAGTGAA	0.323000													12	21					0	0	1	0	0
PTCHD2	57540	broad.mit.edu	37	1	11561920	11561920	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:11561920A>G	ENST00000294484.6	+	2	1009	c.871A>G	c.(871-873)Acc>Gcc	p.T291A	PTCHD2_ENST00000389575.3_Missense_Mutation_p.T291A	NM_020780.1	NP_065831.1	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	291					cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			NS(3)|breast(2)|endometrium(9)|kidney(4)|large_intestine(5)|lung(34)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	76	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		CAACATTTTCACCAGTGAGCG	0.622000													11	20					0	0	1	0	0
XIST	7503	broad.mit.edu	37	X	73053201	73053201	+	RNA	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chrX:73053201C>T	ENST00000429829.1	-	0	11444					NR_001564.2																						CTCACATGCTCAGAATGTCCT	0.428000													15	21					0	0	1	0	0
SEMA3E	9723	broad.mit.edu	37	7	83277821	83277821	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr7:83277821C>A	ENST00000307792.3	-	1	505	c.38G>T	c.(37-39)tGg>tTg	p.W13L		NM_012431.2	NP_036563.1	O15041	SEM3E_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E	13					axon guidance	extracellular space|membrane	receptor activity			breast(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(19)|ovary(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	51		Medulloblastoma(109;0.109)				TAAGTAACCCCACAGGAGCAA	0.527000													8	31					0.000274275	0.000279778	1	1	0
KBTBD7	84078	broad.mit.edu	37	13	41767785	41767785	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr13:41767785G>A	ENST00000379483.3	-	1	917	c.609C>T	c.(607-609)ctC>ctT	p.L203L		NM_032138.4	NP_115514.2	Q8WVZ9	KBTB7_HUMAN	kelch repeat and BTB (POZ) domain containing 7	203							protein binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(8)|ovary(4)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	24		Lung NSC(96;0.000105)|Breast(139;0.00715)|Prostate(109;0.0233)|Lung SC(185;0.0367)		all cancers(112;6.21e-09)|Epithelial(112;6.99e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000196)|GBM - Glioblastoma multiforme(144;0.000857)|BRCA - Breast invasive adenocarcinoma(63;0.0669)		CCATTCGGCTGAGCTGCTTGA	0.547000													22	62					0	0	1	0	0
PUS3	83480	broad.mit.edu	37	11	125764064	125764064	+	Silent	SNP	A	A	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr11:125764064A>G	ENST00000227474.3	-	4	1159	c.1062T>C	c.(1060-1062)aaT>aaC	p.N354N	HYLS1_ENST00000526028.1_Intron|HYLS1_ENST00000356438.3_Intron|HYLS1_ENST00000425380.2_Intron|PUS3_ENST00000530811.1_Silent_p.N354N	NM_001271985.1|NM_031307.3	NP_001258914.1|NP_112597	Q9BZE2	PUS3_HUMAN	pseudouridylate synthase 3	354						nucleus	RNA binding			NS(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)	10	all_hematologic(175;0.177)	Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.131)|all_lung(97;0.139)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.043)		TGACAGCATGATTAGCCCACA	0.418000													41	60					0	0	1	0	0
KIAA1210	57481	broad.mit.edu	37	X	118222888	118222888	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chrX:118222888G>A	ENST00000402510.2	-	11	2304	c.2305C>T	c.(2305-2307)Cag>Tag	p.Q769*		NM_020721.1	NP_065772.1	Q9ULL0	K1210_HUMAN	KIAA1210	769										breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(31)|ovary(4)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	64						CTTGAGGACTGAAAAAGGCTT	0.463000													13	25					0	0	1	0	0
USP4	7375	broad.mit.edu	37	3	49321491	49321491	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:49321491G>A	ENST00000351842.4	-	18	2336	c.2328C>T	c.(2326-2328)gtC>gtT	p.V776V	USP4_ENST00000265560.4_Silent_p.V823V	NM_199443.2	NP_955475.1	Q13107	UBP4_HUMAN	ubiquitin specific peptidase 4 (proto-oncogene)	823					negative regulation of protein ubiquitination|protein deubiquitination|protein localization at cell surface|regulation of protein stability|ubiquitin-dependent protein catabolic process	lysosome|nucleus	adenosine receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|liver(1)|lung(10)|ovary(3)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	33		Ovarian(412;0.00308)|Myeloproliferative disorder(1037;0.0255)|Hepatocellular(537;0.121)		OV - Ovarian serous cystadenocarcinoma(275;4.74e-26)|Kidney(197;2.22e-07)|KIRC - Kidney renal clear cell carcinoma(197;5.14e-06)|BRCA - Breast invasive adenocarcinoma(193;9.46e-05)		GTTTGAGGTGGACCACCAGGA	0.463000													22	80					0	0	1	0	0
NT5E	4907	broad.mit.edu	37	6	86176992	86176992	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr6:86176992C>G	ENST00000257770.3	+	2	603	c.554C>G	c.(553-555)tCa>tGa	p.S185*	NT5E_ENST00000369646.3_Nonsense_Mutation_p.S185*|NT5E_ENST00000369651.3_Nonsense_Mutation_p.S185*	NM_002526.3	NP_002517.1	P21589	5NTD_HUMAN	5'-nucleotidase, ecto (CD73)	185					DNA metabolic process|purine base metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	anchored to membrane|cytoplasm|membrane fraction|plasma membrane	5'-nucleotidase activity|nucleotide binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(9)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		all_cancers(76;0.000215)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0427)		BRCA - Breast invasive adenocarcinoma(108;0.0417)	Pentoxifylline(DB00806)	CCTTTTCTCTCAAATCCAGGT	0.358000													12	23					0	0	1	0	0
PSMD4	5710	broad.mit.edu	37	1	151239669	151239669	+	Silent	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:151239669G>C	ENST00000368884.3	+	10	1064	c.984G>C	c.(982-984)gtG>gtC	p.V328V	PSMD4_ENST00000368881.4_Silent_p.V331V	NM_002810.2	NP_002801.1	P55036	PSMD4_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 4	328					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|viral reproduction	proteasome complex	protein binding|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|lung(7)	11	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			ATTACGACGTGATGCAGGACC	0.562000													39	370					0	0	1	0	0
DHX30	22907	broad.mit.edu	37	3	47888001	47888001	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:47888001G>A	ENST00000446256.2	+	12	1894	c.1322G>A	c.(1321-1323)cGa>cAa	p.R441Q	DHX30_ENST00000348968.4_Missense_Mutation_p.R452Q|DHX30_ENST00000457607.1_Missense_Mutation_p.R508Q|DHX30_ENST00000445061.1_Missense_Mutation_p.R480Q	NM_014966.3	NP_055781.2	Q7L2E3	DHX30_HUMAN	DEAH (Asp-Glu-Ala-His) box helicase 30	480						mitochondrial nucleoid	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			endometrium(3)|kidney(1)|large_intestine(11)|lung(13)|ovary(4)|pancreas(1)|prostate(1)|skin(3)	37				BRCA - Breast invasive adenocarcinoma(193;0.000696)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		ACCGAGGGCCGAGGTGCCCGC	0.652000													44	89					0	0	1	0	0
MGME1	92667	broad.mit.edu	37	20	17950725	17950725	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr20:17950725G>A	ENST00000377710.5	+	2	511	c.223G>A	c.(223-225)Gat>Aat	p.D75N	MGME1_ENST00000377709.1_Missense_Mutation_p.D75N|MGME1_ENST00000467391.1_3'UTR|MGME1_ENST00000377704.4_Missense_Mutation_p.D75N	NM_052865.2	NP_443097.1			mitochondrial genome maintenance exonuclease 1																		GGTGGAGGAAGATGCTTTGCT	0.498000													18	80					0	0	1	0	0
CREB3L3	84699	broad.mit.edu	37	19	4171907	4171907	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:4171907C>G	ENST00000078445.2	+	10	1474	c.1327C>G	c.(1327-1329)Cct>Gct	p.P443A	CREB3L3_ENST00000602257.1_Missense_Mutation_p.P441A|CREB3L3_ENST00000595923.1_Missense_Mutation_p.P442A|CREB3L3_ENST00000252587.3_3'UTR|CREB3L3_ENST00000602147.1_3'UTR	NM_001271995.1|NM_001271996.1|NM_032607.1	NP_001258924.1|NP_001258925.1|NP_115996.1	Q68CJ9	CR3L3_HUMAN	cAMP responsive element binding protein 3-like 3	443					response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|skin(2)|urinary_tract(3)	24				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0232)|STAD - Stomach adenocarcinoma(1328;0.18)		CTGGGTGGCGCCTGGGCCGAG	0.692000													8	15					0	0	1	0	0
RBM14	10432	broad.mit.edu	37	11	66384451	66384451	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr11:66384451C>T	ENST00000310137.4	+	1	399	c.260C>T	c.(259-261)tCg>tTg	p.S87L	RBM4_ENST00000514361.3_Missense_Mutation_p.S87L|RBM14-RBM4_ENST00000412278.2_Missense_Mutation_p.S87L|RBM14-RBM4_ENST00000500635.2_Missense_Mutation_p.S87L|RBM14_ENST00000443702.1_Missense_Mutation_p.S87L|RBM14-RBM4_ENST00000511114.1_3'UTR|RBM14_ENST00000393979.3_Missense_Mutation_p.S87L|RBM14_ENST00000409372.1_Missense_Mutation_p.S87L|RBM4_ENST00000503028.2_5'UTR|RBM14_ENST00000409738.4_Missense_Mutation_p.S87L	NM_006328.3	NP_006319.1	Q96PK6	RBM14_HUMAN	RNA binding motif protein 14	87	RRM 2.				DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|histone deacetylation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus	mediator complex|ribonucleoprotein complex|transcription factor complex	ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|protein binding, bridging|RNA binding|RNA polymerase II transcription cofactor activity		RBM14/PACS1(2)	breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(3)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	17						GGCAATGTGTCGGCTGCATGC	0.662000													30	60					0	0	1	0	0
OR3A2	4995	broad.mit.edu	37	17	3181779	3181779	+	Silent	SNP	T	T	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr17:3181779T>G	ENST00000408891.2	-	1	489	c.451A>C	c.(451-453)Agg>Cgg	p.R151R		NM_002551.3	NP_002542.3	P47893	OR3A2_HUMAN	olfactory receptor, family 3, subfamily A, member 2	151					sensory perception of smell	integral to plasma membrane	olfactory receptor activity			ovary(1)	1						ACCAACATCCTCTGGACTGTC	0.597000													22	91					0	0	1	0	0
NEBL	10529	broad.mit.edu	37	10	21117535	21117535	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr10:21117535A>G	ENST00000377122.4	-	17	2096	c.1700T>C	c.(1699-1701)aTg>aCg	p.M567T	NEBL_ENST00000377159.4_Intron|NEBL_ENST00000417816.2_Intron	NM_006393.2	NP_006384.1	O76041	NEBL_HUMAN	nebulette	567					regulation of actin filament length		actin binding|structural constituent of muscle			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						GTTAGAAAGCATCTTCTCTGC	0.368000													10	27					0	0	1	0	0
FAF2	23197	broad.mit.edu	37	5	175925944	175925944	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr5:175925944G>A	ENST00000261942.6	+	9	922	c.869G>A	c.(868-870)aGa>aAa	p.R290K		NM_014613.2	NP_055428.1	Q96CS3	FAF2_HUMAN	Fas associated factor family member 2	290					response to unfolded protein	endoplasmic reticulum|lipid particle	protein binding			breast(1)|large_intestine(3)|lung(4)|ovary(1)|skin(1)	10						CAAGTGCTGAGACAACAGCAG	0.478000													12	45					0	0	1	0	0
OR14K1	343170	broad.mit.edu	37	1	247902657	247902657	+	Silent	SNP	T	T	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:247902657T>C	ENST00000283225.2	+	1	741	c.741T>C	c.(739-741)acT>acC	p.T247T	RP11-634B7.4_ENST00000449298.1_RNA					olfactory receptor, family 14, subfamily K, member 1											NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|lung(18)|ovary(1)|urinary_tract(1)	27						TTGTTGTCACTGTGTTTCTTG	0.433000													12	31					0	0	1	0	0
HACL1	26061	broad.mit.edu	37	3	15604911	15604911	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:15604911G>A	ENST00000321169.5	-	16	2025	c.1658C>T	c.(1657-1659)tCt>tTt	p.S553F	HACL1_ENST00000435217.2_Missense_Mutation_p.S312F|HACL1_ENST00000451445.2_Missense_Mutation_p.S471F|HACL1_ENST00000457447.2_Missense_Mutation_p.S493F|HACL1_ENST00000456194.2_Missense_Mutation_p.S526F	NM_012260.2	NP_036392.2	Q9UJ83	HACL1_HUMAN	2-hydroxyacyl-CoA lyase 1	553					fatty acid alpha-oxidation	peroxisomal matrix	carbon-carbon lyase activity|identical protein binding|magnesium ion binding|thiamine pyrophosphate binding			NS(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(3)|skin(1)	16						GTTGATAAGAGAAGGTTTAGT	0.458000													8	40					0	0	1	0	0
DCN	1634	broad.mit.edu	37	12	91572179	91572179	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr12:91572179C>G	ENST00000551354.1	-	2	355	c.151G>C	c.(151-153)Ggc>Cgc	p.G51R	DCN_ENST00000546370.1_Missense_Mutation_p.G51R|DCN_ENST00000550099.1_Missense_Mutation_p.G51R|DCN_ENST00000228329.5_Missense_Mutation_p.G51R|DCN_ENST00000052754.5_Missense_Mutation_p.G51R|DCN_ENST00000393155.1_Missense_Mutation_p.G51R|DCN_ENST00000547568.2_Missense_Mutation_p.G51R|DCN_ENST00000420120.2_Missense_Mutation_p.G51R|DCN_ENST00000303320.3_Missense_Mutation_p.G51R|DCN_ENST00000546745.1_Missense_Mutation_p.G51R|DCN_ENST00000425043.1_Missense_Mutation_p.G51R|DCN_ENST00000456569.2_Missense_Mutation_p.G51R|DCN_ENST00000552962.1_Missense_Mutation_p.G51R|DCN_ENST00000441303.2_Missense_Mutation_p.G51R			P07585	PGS2_HUMAN	decorin	51					organ morphogenesis	extracellular space				central_nervous_system(2)|cervix(1)|kidney(2)|large_intestine(4)|liver(1)|lung(8)|ovary(1)|skin(1)	20						CACACTGGGCCTAGGGAGGGC	0.507000											OREG0022021	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	26	86					0	0	1	0	0
HELB	92797	broad.mit.edu	37	12	66712454	66712454	+	Silent	SNP	A	A	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr12:66712454A>G	ENST00000247815.4	+	7	2096	c.2037A>G	c.(2035-2037)gaA>gaG	p.E679E		NM_033647.3	NP_387467.2	Q8NG08	HELB_HUMAN	helicase (DNA) B	679					DNA replication, synthesis of RNA primer		ATP binding|ATP-dependent 5'-3' DNA helicase activity|single-stranded DNA-dependent ATP-dependent DNA helicase activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(15)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	40			GBM - Glioblastoma multiforme(2;0.000142)	GBM - Glioblastoma multiforme(28;0.0265)		TTGATGCAGAACTAAATATCT	0.338000													8	43					0	0	1	0	0
IL10RB	3588	broad.mit.edu	37	21	34655483	34655483	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr21:34655483C>T	ENST00000290200.2	+	5	691	c.583C>T	c.(583-585)Ctt>Ttt	p.L195F	AP000295.9_ENST00000433395.2_Silent_p.F322F	NM_000628.4	NP_000619.3			interleukin 10 receptor, beta											endometrium(1)|kidney(1)|large_intestine(6)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	14						TCGAGGGTTTCTTCCTGATCG	0.473000													47	46					0	0	1	0	0
RHBG	57127	broad.mit.edu	37	1	156351923	156351923	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:156351923C>T	ENST00000400992.2	+	7	1315	c.947C>T	c.(946-948)cCg>cTg	p.P316L	RHBG_ENST00000451864.2_Missense_Mutation_p.P270L|RHBG_ENST00000368246.2_Missense_Mutation_p.P348L|RHBG_ENST00000537040.1_Missense_Mutation_p.R181W|RHBG_ENST00000255013.3_Missense_Mutation_p.P279L|RHBG_ENST00000368249.1_Missense_Mutation_p.P348L			Q9H310	RHBG_HUMAN	Rh family, B glycoprotein (gene/pseudogene)	348					transepithelial ammonium transport	anchored to plasma membrane|basolateral plasma membrane|cytoplasmic vesicle membrane|integral to plasma membrane|spectrin-associated cytoskeleton	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(3)|skin(2)|stomach(1)|urinary_tract(1)	22	Hepatocellular(266;0.158)					CATGGGATGCCGGGGGTCCTG	0.577000													32	128					0	0	1	0	0
DNAJB5	25822	broad.mit.edu	37	9	34996275	34996275	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr9:34996275C>T	ENST00000541010.1	+	2	3237	c.225C>T	c.(223-225)ggC>ggT	p.G75G	DNAJB5_ENST00000453597.3_Silent_p.G189G|DNAJB5_ENST00000545841.1_Silent_p.G75G|DNAJB5_ENST00000335998.3_Silent_p.G109G|DNAJB5_ENST00000454002.2_Silent_p.G147G|DNAJB5_ENST00000312316.5_Silent_p.G75G			O75953	DNJB5_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 5	75					protein folding|response to unfolded protein		heat shock protein binding|unfolded protein binding			kidney(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	12			LUSC - Lung squamous cell carcinoma(32;0.00575)			TGAAGACCGGCGGTGGCACAT	0.597000													6	60					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196865601	196865601	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:196865601C>A	ENST00000312428.6	-	12	1280	c.1180G>T	c.(1180-1182)Gtt>Ttt	p.V394F	DNAH7_ENST00000410072.1_Missense_Mutation_p.V394F	NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	394	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						AAAGCTCTAACAGAATCCTGC	0.333000													10	37					6.40141e-05	6.5925e-05	1	1	0
HTR3E	285242	broad.mit.edu	37	3	183822015	183822015	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:183822015G>A	ENST00000415389.2	+	4	791	c.325G>A	c.(325-327)Ggc>Agc	p.G109S	HTR3E_ENST00000335304.2_Missense_Mutation_p.G124S|HTR3E_ENST00000440596.2_Missense_Mutation_p.G109S|HTR3E-AS1_ENST00000431427.1_RNA|HTR3E_ENST00000425359.2_Missense_Mutation_p.G94S|HTR3E_ENST00000436361.2_Missense_Mutation_p.G109S	NM_001256613.1|NM_198313.2	NP_001243542.1|NP_938055.1	A5X5Y0	5HT3E_HUMAN	5-hydroxytryptamine (serotonin) receptor 3E, ionotropic	109						integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(20)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	40	all_cancers(143;1.46e-10)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			GGAATGTGAGGGCATCACGAA	0.488000													6	33					0	0	1	0	0
CLEC17A	388512	broad.mit.edu	37	19	14710593	14710593	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:14710593C>T	ENST00000547437.1	+	11	788	c.711C>T	c.(709-711)aaC>aaT	p.N237N	CLEC17A_ENST00000417570.1_Silent_p.N237N|CLEC17A_ENST00000397439.2_Silent_p.N220N	NM_207390.3	NP_997273.3	Q6ZS10	CL17A_HUMAN	C-type lectin domain family 17, member A	237						cell surface|integral to membrane	fucose binding|mannose binding|metal ion binding|receptor activity										CTGACACCAACCAGTCCCTGG	0.552000													19	15					0	0	1	0	0
RALGDS	5900	broad.mit.edu	37	9	135973980	135973980	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr9:135973980G>A	ENST00000393160.3	-	18	2927	c.2574C>T	c.(2572-2574)atC>atT	p.I858I	RALGDS_ENST00000372062.3_Silent_p.I884I|RALGDS_ENST00000469972.1_5'UTR|RALGDS_ENST00000372050.3_Silent_p.I913I|RALGDS_ENST00000393157.3_Silent_p.I912I|RALGDS_ENST00000542690.1_Silent_p.I984I|RALGDS_ENST00000372047.3_Silent_p.I901I	NM_001042368.1	NP_001035827.1	Q12967	GNDS_HUMAN	ral guanine nucleotide dissociation stimulator	913	Ras-associating.				nerve growth factor receptor signaling pathway|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol	Ral guanyl-nucleotide exchange factor activity			endometrium(1)|large_intestine(4)|lung(2)|ovary(1)|upper_aerodigestive_tract(2)	10				OV - Ovarian serous cystadenocarcinoma(145;3.66e-06)|Epithelial(140;2.77e-05)		GCCCTCAGAAGATGCCCTTGG	0.612000			T	CIITA	"""PMBL, Hodgkin Lymphona, """								9	39					0	0	1	0	0
DOCK10	55619	broad.mit.edu	37	2	225739015	225739015	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:225739015G>A	ENST00000409592.3	-	10	1164	c.1051C>T	c.(1051-1053)Cta>Tta	p.L351L	DOCK10_ENST00000258390.7_Silent_p.L357L			Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	357							GTP binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(10)|large_intestine(16)|lung(40)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	87		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		AACAGATTTAGCCTCTCCATG	0.338000													5	7					0	0	1	0	0
C7orf62	219557	broad.mit.edu	37	7	88423870	88423870	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr7:88423870C>T	ENST00000297203.2	-	2	572	c.387G>A	c.(385-387)atG>atA	p.M129I	ZNF804B_ENST00000333190.4_Intron	NM_152706.3	NP_689919.1	Q8TBZ9	CG062_HUMAN	chromosome 7 open reading frame 62	129										NS(1)|breast(1)|endometrium(3)|large_intestine(8)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	30						CTATAATTTTCATTTGTTGAA	0.348000													7	37					0	0	1	0	0
MGME1	92667	broad.mit.edu	37	20	17950748	17950748	+	Silent	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr20:17950748G>C	ENST00000377710.5	+	2	534	c.246G>C	c.(244-246)gtG>gtC	p.V82V	MGME1_ENST00000377709.1_Silent_p.V82V|MGME1_ENST00000467391.1_3'UTR|MGME1_ENST00000377704.4_Silent_p.V82V	NM_052865.2	NP_443097.1			mitochondrial genome maintenance exonuclease 1																		GTGGACCCGTGAGCAAGCATA	0.483000													17	69					0	0	1	0	0
CALB1	793	broad.mit.edu	37	8	91094304	91094304	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr8:91094304G>A	ENST00000265431.3	-	2	287	c.106C>T	c.(106-108)Ctg>Ttg	p.L36L		NM_004929.2	NP_004920.1	P05937	CALB1_HUMAN	calbindin 1, 28kDa	36	EF-hand 1.					nucleus	calcium ion binding|vitamin D binding			breast(1)|kidney(1)|lung(8)|pancreas(1)	11			BRCA - Breast invasive adenocarcinoma(11;0.00953)			AAGTTCTGCAGCTCCTTTCCT	0.463000													48	95					0	0	1	0	0
RNF144A	9781	broad.mit.edu	37	2	7137190	7137190	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:7137190C>T	ENST00000320892.6	+	3	575	c.133C>T	c.(133-135)Ctg>Ttg	p.L45L	RNF144A_ENST00000467276.1_Intron	NM_014746.3	NP_055561.2	P50876	R144A_HUMAN	ring finger protein 144A	45						Golgi apparatus|integral to membrane	ligase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(15)|ovary(1)|prostate(1)	25	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)	all_cancers(51;0.226)		OV - Ovarian serous cystadenocarcinoma(76;0.195)		CTTCTGTACTCTGGTTGGTCT	0.458000													24	84					0	0	1	0	0
SPTBN4	57731	broad.mit.edu	37	19	41063186	41063186	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:41063186G>C	ENST00000352632.3	+	26	5633	c.5547G>C	c.(5545-5547)caG>caC	p.Q1849H	SPTBN4_ENST00000595535.1_Missense_Mutation_p.Q1849H|SPTBN4_ENST00000598249.1_Missense_Mutation_p.Q1849H|SPTBN4_ENST00000338932.3_Missense_Mutation_p.Q1849H|SPTBN4_ENST00000392025.1_Missense_Mutation_p.Q592H|SPTBN4_ENST00000392023.1_Missense_Mutation_p.Q525H			Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4	1849					actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			breast(4)|central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	73			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			TTCAGGGACAGATTGAGGAGA	0.652000													20	44					0	0	1	0	0
KAT6B	23522	broad.mit.edu	37	10	76735740	76735740	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr10:76735740C>G	ENST00000287239.4	+	8	2134	c.1645C>G	c.(1645-1647)Cat>Gat	p.H549D	KAT6B_ENST00000372725.1_Intron|KAT6B_ENST00000372714.1_Intron|KAT6B_ENST00000372711.1_Intron|KAT6B_ENST00000372724.1_Intron	NM_001256468.1|NM_012330.3	NP_001243397.1|NP_036462.2	Q8WYB5	MYST4_HUMAN	K(lysine) acetyltransferase 6B	549	Negatively regulates HAT activity.				histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding										TGGGCTTTCTCATATCTATAC	0.512000													28	62					0	0	1	0	0
BOD1L1	259282	broad.mit.edu	37	4	13602476	13602476	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr4:13602476G>A	ENST00000040738.5	-	10	6183	c.6048C>T	c.(6046-6048)gtC>gtT	p.V2016V		NM_148894.2	NP_683692.2	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division 1-like 1	2016							DNA binding										CACATTCTGGGACTTCACCAG	0.438000													7	19					0	0	1	0	0
YPEL5	51646	broad.mit.edu	37	2	30381638	30381638	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:30381638G>A	ENST00000379520.3	+	5	799	c.295G>A	c.(295-297)Gtg>Atg	p.V99M	YPEL5_ENST00000402003.3_Missense_Mutation_p.V99M|YPEL5_ENST00000402708.1_Missense_Mutation_p.V99M|YPEL5_ENST00000261353.4_Missense_Mutation_p.V99M|YPEL5_ENST00000379519.3_Missense_Mutation_p.V99M|YPEL5_ENST00000495673.1_3'UTR	NM_001127401.1	NP_001120873.1	P62699	YPEL5_HUMAN	yippee-like 5 (Drosophila)	99							peptide-methionine-(S)-S-oxide reductase activity			NS(1)|endometrium(1)|kidney(1)|lung(3)|prostate(1)	7	Acute lymphoblastic leukemia(172;0.155)					GGAAGGCCGCGTGATCCTGGA	0.473000													12	92					0	0	1	0	0
MID1	4281	broad.mit.edu	37	X	10534931	10534931	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chrX:10534931C>T	ENST00000317552.4	-	2	1057	c.657G>A	c.(655-657)ttG>ttA	p.L219L	MID1_ENST00000453318.2_Silent_p.L219L|MID1_ENST00000380782.2_Silent_p.L219L|MID1_ENST00000380779.1_Silent_p.L219L|MID1_ENST00000380780.1_Silent_p.L219L|MID1_ENST00000380787.1_Silent_p.L219L|MID1_ENST00000380785.1_Silent_p.L219L	NM_000381.3|NM_033289.1	NP_000372.1|NP_150631.1	O15344	TRI18_HUMAN	midline 1 (Opitz/BBB syndrome)	219					microtubule cytoskeleton organization|pattern specification process|positive regulation of stress-activated MAPK cascade	cytoplasm|microtubule|microtubule associated complex|spindle	ligase activity|ubiquitin protein ligase binding|zinc ion binding	p.L219F(1)		breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(9)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	26						GACTAACCTTCAATTTGTCAT	0.478000													20	33					0	0	1	0	0
EXOC3	11336	broad.mit.edu	37	5	464459	464459	+	Missense_Mutation	SNP	G	G	C	rs140433753	by1000genomes	TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr5:464459G>C	ENST00000512944.1	+	10	1897	c.1708G>C	c.(1708-1710)Gac>Cac	p.D570H	EXOC3_ENST00000315013.5_Missense_Mutation_p.D570H	NM_007277.4	NP_009208.2	O60645	EXOC3_HUMAN	exocyst complex component 3	581					exocytosis|protein transport					breast(2)|cervix(1)|endometrium(4)|large_intestine(1)|lung(13)|ovary(1)|urinary_tract(1)	23		Ovarian(839;0.0563)	Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			AAACGCTGTAGACATTATCTG	0.413000													17	785					0	0	1	0	0
DENND4C	55667	broad.mit.edu	37	9	19290806	19290806	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr9:19290806G>A	ENST00000380432.2	+	1	58	c.25G>A	c.(25-27)Gat>Aat	p.D9N	DENND4C_ENST00000602925.1_Missense_Mutation_p.D245N|DENND4C_ENST00000434457.2_Missense_Mutation_p.D245N			Q5VZ89	DEN4C_HUMAN	DENN/MADD domain containing 4C	9	UDENN.					integral to membrane				breast(1)|endometrium(8)|kidney(1)|large_intestine(7)|liver(2)|lung(13)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40						TGAGTGCTGGGATCCTGAAAC	0.373000													8	58					0	0	1	0	0
SLCO4A1	28231	broad.mit.edu	37	20	61288065	61288065	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr20:61288065G>A	ENST00000217159.1	+	2	464	c.259G>A	c.(259-261)Ggc>Agc	p.G87S	SLCO4A1_ENST00000370507.1_Missense_Mutation_p.G87S	NM_016354.3	NP_057438.3	Q96BD0	SO4A1_HUMAN	solute carrier organic anion transporter family, member 4A1	87					sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			endometrium(6)|kidney(2)|large_intestine(1)|lung(7)|ovary(3)|prostate(2)	21	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;2.33e-06)			CGTGGCGTGCGGCTGGTGGGC	0.687000													8	19					0	0	1	0	0
EN1	2019	broad.mit.edu	37	2	119600673	119600673	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:119600673G>A	ENST00000295206.6	-	2	1530	c.1020C>T	c.(1018-1020)ctC>ctT	p.L340L		NM_001426.3	NP_001417.3	Q05925	HME1_HUMAN	engrailed homeobox 1	340					skeletal system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(2)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	9						CGTTGAGGCTGAGTTCCTGGG	0.612000													17	24					0	0	1	0	0
GPR141	353345	broad.mit.edu	37	7	37780027	37780027	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr7:37780027C>T	ENST00000447769.1	+	4	321	c.32C>T	c.(31-33)tCt>tTt	p.S11F	GPR141_ENST00000334425.1_Missense_Mutation_p.S11F|EPDR1_ENST00000476620.1_Intron|GPR141_ENST00000461610.1_Intron			Q7Z602	GP141_HUMAN	G protein-coupled receptor 141	11						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(13)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						AGGAATTCCTCTTGCGATCCT	0.473000													39	165					0	0	1	0	0
GTF3C1	2975	broad.mit.edu	37	16	27518218	27518218	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr16:27518218G>A	ENST00000356183.4	-	9	1517	c.1502C>T	c.(1501-1503)tCt>tTt	p.S501F	GTF3C1_ENST00000561623.1_Missense_Mutation_p.S501F	NM_001520.3	NP_001511.2	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide 1, alpha 220kDa	501						transcription factor TFIIIC complex	DNA binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|liver(3)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	80						GAGGTTTGCAGAGGCTCTTGT	0.637000													12	47					0	0	1	0	0
DHX34	9704	broad.mit.edu	37	19	47883052	47883052	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:47883052C>G	ENST00000328771.4	+	14	3141	c.2792C>G	c.(2791-2793)gCa>gGa	p.A931G		NM_014681.5	NP_055496.2	Q14147	DHX34_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 34	931						intracellular	ATP binding|ATP-dependent helicase activity|RNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(8)|ovary(5)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;7.16e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000489)|GBM - Glioblastoma multiforme(486;0.00413)|Epithelial(262;0.0132)		CTGCAGCTAGCAGACAGTGAA	0.652000													23	89					0	0	1	0	0
LHCGR	3973	broad.mit.edu	37	2	48915552	48915552	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:48915552G>C	ENST00000294954.7	-	11	1405	c.1384C>G	c.(1384-1386)Cta>Gta	p.L462V	LHCGR_ENST00000403273.1_3'UTR|LHCGR_ENST00000401907.1_Intron|LHCGR_ENST00000405626.1_Missense_Mutation_p.L435V|LHCGR_ENST00000344775.3_Missense_Mutation_p.L400V|STON1-GTF2A1L_ENST00000402114.2_Intron	NM_000233.3	NP_000224.2	P22888	LSHR_HUMAN	luteinizing hormone/choriogonadotropin receptor	462					male genitalia development|male gonad development	endosome|integral to plasma membrane	luteinizing hormone receptor activity			NS(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|liver(1)|lung(23)|ovary(3)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	56		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Cetrorelix(DB00050)|Choriogonadotropin alfa(DB00097)|Goserelin(DB00014)|Lutropin alfa(DB00044)|Menotropins(DB00032)	CATCTTTCTAGAGTGATGACG	0.483000													14	88					0	0	1	0	0
CUL4B	8450	broad.mit.edu	37	X	119694219	119694219	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chrX:119694219G>A	ENST00000371322.5	-	1	336	c.275C>T	c.(274-276)tCc>tTc	p.S92F	CUL4B_ENST00000336592.6_Missense_Mutation_p.S97F|CUL4B_ENST00000404115.3_Missense_Mutation_p.S110F	NM_001079872.1	NP_001073341.1	Q13620	CUL4B_HUMAN	cullin 4B	110	Ser-rich.				cell cycle|DNA repair|ubiquitin-dependent protein catabolic process	Cul4B-RING ubiquitin ligase complex|nucleus	protein binding|ubiquitin protein ligase binding	p.S92F(1)|p.S110F(1)		NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(14)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						TACGTGGCTGGAAGCAGCCAC	0.547000													24	39					0	0	1	0	0
CILP2	148113	broad.mit.edu	37	19	19655508	19655508	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:19655508C>T	ENST00000586018.1	+	8	2274	c.2172C>T	c.(2170-2172)aaC>aaT	p.N724N	CILP2_ENST00000291495.5_Silent_p.N718N			Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	718						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(17)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	32						TGGTGGGCAACGTGGAGATCC	0.706000													4	24					0	0	1	0	0
CCNT2	905	broad.mit.edu	37	2	135694537	135694537	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:135694537G>C	ENST00000264157.5	+	3	397	c.367G>C	c.(367-369)Gat>Cat	p.D123H	CCNT2_ENST00000537343.1_5'UTR|CCNT2_ENST00000295238.6_Missense_Mutation_p.D123H	NM_001241.3|NM_058241.2	NP_001232.1|NP_490595.1	O60583	CCNT2_HUMAN	cyclin T2	123					cell cycle|cell division|interspecies interaction between organisms|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	protein kinase binding			endometrium(2)|kidney(3)|large_intestine(10)|lung(6)|ovary(2)|prostate(1)|skin(1)	25				BRCA - Breast invasive adenocarcinoma(221;0.107)		TACTAAATGTGATGTATGTAA	0.358000													9	32					0	0	1	0	0
LEPREL1	55214	broad.mit.edu	37	3	189713102	189713102	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:189713102C>G	ENST00000319332.5	-	2	807	c.610G>C	c.(610-612)Gac>Cac	p.D204H	LEPREL1_ENST00000427335.2_Missense_Mutation_p.D23H	NM_018192.3	NP_060662.2	Q8IVL5	P3H2_HUMAN	leprecan-like 1	204					collagen metabolic process|negative regulation of cell proliferation|peptidyl-proline hydroxylation	basement membrane|endoplasmic reticulum|Golgi apparatus	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(10)|liver(1)|lung(8)|ovary(2)|prostate(2)|skin(5)	41	all_cancers(143;4.01e-10)|Ovarian(172;0.0925)		Lung(62;4.35e-05)	GBM - Glioblastoma multiforme(93;0.02)	L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	GCTTCTCTGTCTACCAACTGC	0.498000													18	67					0	0	1	0	0
ANXA5	308	broad.mit.edu	37	4	122599105	122599105	+	Splice_Site	SNP	C	C	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr4:122599105C>A	ENST00000296511.5	-	8	760	c.475G>T	c.(475-477)Gct>Tct	p.A159S	ANXA5_ENST00000501272.2_Splice_Site_p.A99S|ANXA5_ENST00000515017.1_Splice_Site_p.A59S	NM_001154.3	NP_001145.1	P08758	ANXA5_HUMAN	annexin A5	159					anti-apoptosis|blood coagulation|negative regulation of coagulation|signal transduction	cytoplasm	calcium ion binding|calcium-dependent phospholipid binding|phospholipase inhibitor activity			NS(1)|breast(1)|endometrium(2)|large_intestine(1)|lung(9)|ovary(1)	15						TCTCTGTTAGCCTATGAGAGG	0.378000													13	43					2.32078e-09	2.44213e-09	1	1	0
SMC2	10592	broad.mit.edu	37	9	106889711	106889711	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr9:106889711G>A	ENST00000286398.7	+	20	3028	c.2740G>A	c.(2740-2742)Gac>Aac	p.D914N	SMC2_ENST00000374787.3_Missense_Mutation_p.D914N|SMC2_ENST00000303219.8_Missense_Mutation_p.D914N|SMC2_ENST00000374793.3_Missense_Mutation_p.D914N	NM_001042551.1|NM_001265602.1|NM_006444.2	NP_001036016.1|NP_001252531.1|NP_006435.2	O95347	SMC2_HUMAN	structural maintenance of chromosomes 2	914					cell division|mitotic chromosome condensation|symbiosis, encompassing mutualism through parasitism	condensin complex|cytoplasm|nuclear chromosome	ATP binding|protein heterodimerization activity	p.D914N(2)		breast(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(14)|ovary(5)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	48						TAAGGAATTAGACCACAACAT	0.363000													10	51					0	0	1	0	0
DOC2A	8448	broad.mit.edu	37	16	30017614	30017614	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr16:30017614G>C	ENST00000350119.4	-	11	1286	c.1096C>G	c.(1096-1098)Cgg>Ggg	p.R366G	DOC2A_ENST00000564979.1_Missense_Mutation_p.R366G|DOC2A_ENST00000564944.1_Missense_Mutation_p.R366G	NM_001282062.1|NM_001282063.1|NM_001282068.1|NM_003586.2	NP_001268991.1|NP_001268992.1|NP_001268997.1|NP_003577.2	Q14183	DOC2A_HUMAN	double C2-like domains, alpha	366	Interaction with UNC13D.				nervous system development|regulation of calcium ion-dependent exocytosis	cell junction|lysosome|synaptic vesicle membrane|synaptosome	calcium-dependent phospholipid binding|protein binding|transporter activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(2)|ovary(2)	9						CAGTGCTTCCGAGCCTCGCCT	0.726000													17	32					0	0	1	0	0
IGF2R	3482	broad.mit.edu	37	6	160464285	160464285	+	Missense_Mutation	SNP	G	G	A	rs6413489	byFrequency	TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr6:160464285G>A	ENST00000356956.1	+	12	1734	c.1586G>A	c.(1585-1587)cGa>cAa	p.R529Q		NM_000876.2	NP_000867	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor	529			R -> Q (in dbSNP:rs6413489).		receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			breast(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(27)|lung(31)|ovary(3)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		GGCAAGGCACGAGGGTGTCCC	0.502000													24	100					0	0	1	0	0
OVOL2	58495	broad.mit.edu	37	20	18005586	18005586	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr20:18005586G>A	ENST00000278780.6	-	4	764	c.522C>T	c.(520-522)ccC>ccT	p.P174P	OVOL2_ENST00000483661.1_5'UTR	NM_021220.2	NP_067043.2	Q9BRP0	OVOL2_HUMAN	ovo-like zinc finger 2	174					negative regulation of keratinocyte differentiation|negative regulation of Notch signaling pathway|negative regulation of transcription by competitive promoter binding|regulation of cell cycle|regulation of keratinocyte proliferation|transcription, DNA-dependent	nucleus	DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(3)	6						TGCATTTGTAGGGACGAATGC	0.517000													27	96					0	0	1	0	0
MMP9	4318	broad.mit.edu	37	20	44639824	44639824	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr20:44639824A>C	ENST00000372330.3	+	5	711	c.692A>C	c.(691-693)cAc>cCc	p.H231P		NM_004994.2	NP_004985.2	P14780	MMP9_HUMAN	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	231	Fibronectin type-II 1.				collagen catabolic process|macrophage differentiation|positive regulation of keratinocyte migration|proteolysis	extracellular space|proteinaceous extracellular matrix	collagen binding|metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(4)|large_intestine(14)|liver(2)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(3)	46		Myeloproliferative disorder(115;0.0122)			Glucosamine(DB01296)|Marimastat(DB00786)|Minocycline(DB01017)|Simvastatin(DB00641)	GCGGCCTGCCACTTCCCCTTC	0.637000													59	117					0	0	1	0	0
TBC1D12	23232	broad.mit.edu	37	10	96162370	96162370	+	Translation_Start_Site	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr10:96162370G>A	ENST00000225235.4	+	0	110					NM_015188.1	NP_056003.1	O60347	TBC12_HUMAN	TBC1 domain family, member 12							intracellular	Rab GTPase activator activity			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|upper_aerodigestive_tract(2)	20		Colorectal(252;0.0429)				CCCACCCCCAGATGGTGGGTC	0.697000													12	26					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144892563	144892563	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:144892563C>G	ENST00000369359.4	-	25	3291	c.3253G>C	c.(3253-3255)Gat>Cat	p.D1085H	PDE4DIP_ENST00000524974.1_5'UTR|PDE4DIP_ENST00000530740.1_Missense_Mutation_p.D1085H|PDE4DIP_ENST00000369351.3_Missense_Mutation_p.D948H|PDE4DIP_ENST00000369354.3_Missense_Mutation_p.D948H|PDE4DIP_ENST00000369356.4_Missense_Mutation_p.D948H|PDE4DIP_ENST00000313382.9_Missense_Mutation_p.D1014H|PDE4DIP_ENST00000313431.9_Missense_Mutation_p.D1111H|PDE4DIP_ENST00000369349.3_Missense_Mutation_p.D948H			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	948					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		GTGCTTGTATCTTCGGTGTCA	0.493000			T	PDGFRB	MPD								120	123					0	0	1	0	0
LARP7	51574	broad.mit.edu	37	4	113567980	113567980	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr4:113567980A>T	ENST00000509061.1	+	7	745	c.442A>T	c.(442-444)Att>Ttt	p.I148F	LARP7_ENST00000344442.5_Missense_Mutation_p.I141F|MIR302B_ENST00000509938.1_RNA|MIR302B_ENST00000510655.1_RNA|MIR302B_ENST00000505215.1_RNA|LARP7_ENST00000324052.6_Missense_Mutation_p.I141F	NM_001267039.1	NP_001253968.1	Q4G0J3	LARP7_HUMAN	La ribonucleoprotein domain family, member 7	141	RRM.				RNA processing	nucleoplasm|ribonucleoprotein complex	nucleotide binding|RNA binding			endometrium(2)|large_intestine(2)|lung(8)|ovary(4)|skin(1)	17		Ovarian(17;0.0443)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000603)		TCACAGCTGGATTGAAAGAGT	0.294000													18	37					0	0	1	0	0
HGD	3081	broad.mit.edu	37	3	120365178	120365178	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:120365178C>G	ENST00000283871.5	-	9	1044	c.585G>C	c.(583-585)gaG>gaC	p.E195D		NM_000187.3	NP_000178.2	Q93099	HGD_HUMAN	homogentisate 1,2-dioxygenase	195					L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	homogentisate 1,2-dioxygenase activity|metal ion binding			cervix(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(2)	25				GBM - Glioblastoma multiforme(114;0.158)		AGCCCCTGGTCTCCTCAAAGA	0.473000													14	116					0	0	1	0	0
PMM1	5372	broad.mit.edu	37	22	41982157	41982157	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr22:41982157C>T	ENST00000216259.7	-	2	212	c.128G>A	c.(127-129)cGa>cAa	p.R43Q	PMM1_ENST00000466645.1_5'UTR	NM_002676.2	NP_002667.2	Q92871	PMM1_HUMAN	phosphomannomutase 1	43					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	cytosol	metal ion binding|phosphomannomutase activity			NS(1)|large_intestine(4)|lung(3)|ovary(1)|urinary_tract(2)	11						CACTCTACTTCGTAGCTTCTG	0.562000													37	61					0	0	1	0	0
FN3KRP	79672	broad.mit.edu	37	17	80676928	80676928	+	Silent	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr17:80676928G>C	ENST00000269373.6	+	2	361	c.288G>C	c.(286-288)ctG>ctC	p.L96L	FN3KRP_ENST00000535965.1_Silent_p.L46L	NM_024619.3	NP_078895.2	Q9HA64	KT3K_HUMAN	fructosamine 3 kinase related protein	96							kinase activity			breast(1)|large_intestine(2)|lung(1)|ovary(2)|upper_aerodigestive_tract(1)	7	Breast(20;0.000523)|all_neural(118;0.0952)		BRCA - Breast invasive adenocarcinoma(99;0.0344)|OV - Ovarian serous cystadenocarcinoma(97;0.061)			TGAGGCATCTGAGCAGGTGCA	0.537000													34	41					0	0	1	0	0
CCDC88A	55704	broad.mit.edu	37	2	55559806	55559806	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:55559806C>T	ENST00000436346.1	-	16	3592	c.2751G>A	c.(2749-2751)aaG>aaA	p.K917K	AC012358.8_ENST00000594078.1_RNA|AC012358.8_ENST00000599475.1_RNA|CCDC88A_ENST00000336838.6_Silent_p.K917K|AC012358.8_ENST00000600219.1_RNA|AC012358.8_ENST00000608103.1_RNA|CCDC88A_ENST00000263630.8_Silent_p.K917K|CCDC88A_ENST00000413716.2_Silent_p.K917K|AC012358.8_ENST00000599352.1_RNA	NM_001135597.1|NM_001254943.1	NP_001129069.1|NP_001241872.1	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A	917					activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(22)|lung(23)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|urinary_tract(1)	69						TCTGTTGGGTCTTCAACTTTT	0.343000													10	48					0	0	1	0	0
MED22	6837	broad.mit.edu	37	9	136213410	136213410	+	Silent	SNP	G	G	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr9:136213410G>T	ENST00000491289.1	-	2	689	c.108C>A	c.(106-108)atC>atA	p.I36I	MED22_ENST00000371999.1_Silent_p.I36I|MED22_ENST00000343730.5_Silent_p.I36I|MED22_ENST00000476080.1_Silent_p.I36I|MED22_ENST00000471524.1_Intron|MED22_ENST00000344469.5_Silent_p.I36I			Q15528	MED22_HUMAN	mediator complex subunit 22	36					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|mediator complex|soluble fraction	protein binding			endometrium(1)|large_intestine(1)|ovary(1)|urinary_tract(1)	4				OV - Ovarian serous cystadenocarcinoma(145;1.14e-06)|Epithelial(140;8.2e-06)|all cancers(34;6.94e-05)		CGGTCTTGATGATCTCGGTGA	0.607000													10	49					4.68919e-08	4.91297e-08	1	1	0
RP11-252A24.2	0	broad.mit.edu	37	16	74387794	74387794	+	RNA	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr16:74387794G>A	ENST00000429810.2	-	0	449																											GAACCTGGTAGAGCCAGCAGC	0.468000													24	16					0	0	1	0	0
DHX9	1660	broad.mit.edu	37	1	182822539	182822539	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:182822539C>G	ENST00000367549.3	+	5	573	c.463C>G	c.(463-465)Caa>Gaa	p.Q155E		NM_001357.4	NP_001348.2	Q08211	DHX9_HUMAN	DEAH (Asp-Glu-Ala-His) box helicase 9	155	Interaction with CREBBP.				CRD-mediated mRNA stabilization|nuclear mRNA splicing, via spliceosome	centrosome|CRD-mediated mRNA stability complex|nucleolus|nucleoplasm|ribonucleoprotein complex	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|double-stranded RNA binding|protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(10)|kidney(3)|large_intestine(7)|liver(1)|lung(19)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	49						AAAGGAAGAACAAGAAGTGCA	0.468000													14	72					0	0	1	0	0
TRAV8-4	28682	broad.mit.edu	37	14	22363137	22363137	+	RNA	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr14:22363137G>A	ENST00000390438.2	+	0	396																											TAAGAAGAGTGAAACCTCCTT	0.522000													67	68					0	0	1	0	0
MSH2	4436	broad.mit.edu	37	2	47709968	47709968	+	Silent	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:47709968C>G	ENST00000233146.2	+	16	2908	c.2685C>G	c.(2683-2685)ccC>ccG	p.P895P	MSH2_ENST00000406134.1_Intron|MSH2_ENST00000543555.1_Silent_p.P829P|MSH2_ENST00000461394.1_Intron	NM_000251.2	NP_000242.1	P43246	MSH2_HUMAN	mutS homolog 2	895					B cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|double-strand break repair|intra-S DNA damage checkpoint|isotype switching|maintenance of DNA repeat elements|male gonad development|meiotic gene conversion|meiotic mismatch repair|negative regulation of neuron apoptosis|negative regulation of reciprocal meiotic recombination|positive regulation of helicase activity|postreplication repair|response to UV-B|response to X-ray|somatic hypermutation of immunoglobulin genes	MutSalpha complex|MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|guanine/thymine mispair binding|loop DNA binding|protein C-terminus binding|protein homodimerization activity|protein kinase binding|Y-form DNA binding	p.0?(2)|p.?(2)		NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(9)|kidney(5)|large_intestine(50)|lung(18)|ovary(5)|prostate(2)|skin(3)|small_intestine(1)|stomach(2)|urinary_tract(1)	112		all_hematologic(82;0.0359)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			AACAAATGCCCTTTACTGAAA	0.303000			"""D, Mis, N, F, S"""		"""colorectal, endometrial, ovarian"""	"""colorectal, endometrial, ovarian"""		Mismatch excision repair (MMR)	Turcot syndrome;Muir-Torre syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome				9	21					0	0	1	0	0
REXO1	57455	broad.mit.edu	37	19	1828172	1828172	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:1828172C>T	ENST00000170168.4	-	2	710	c.616G>A	c.(616-618)Gtg>Atg	p.V206M	REXO1_ENST00000587524.1_5'UTR	NM_020695.3	NP_065746.3	Q8N1G1	REXO1_HUMAN	REX1, RNA exonuclease 1 homolog (S. cerevisiae)	206						nucleus	exonuclease activity|nucleic acid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	16		Ovarian(11;1.78e-06)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCTGGCTCACAGCCTTGGGG	0.677000													4	6					0	0	1	0	0
ESYT1	23344	broad.mit.edu	37	12	56531979	56531979	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr12:56531979G>C	ENST00000394048.5	+	21	2524	c.2260G>C	c.(2260-2262)Gag>Cag	p.E754Q	ESYT1_ENST00000541590.1_Missense_Mutation_p.E764Q|ESYT1_ENST00000550878.1_3'UTR|ESYT1_ENST00000267113.4_Missense_Mutation_p.E764Q	NM_001184796.1|NM_015292.2	NP_001171725.1|NP_056107.1	Q9BSJ8	ESYT1_HUMAN	extended synaptotagmin-like protein 1	754						integral to membrane				breast(2)|endometrium(2)|large_intestine(4)|lung(10)|ovary(5)|prostate(1)|skin(3)|urinary_tract(1)	28						GCTGACCCTGGAGGATGTCCC	0.582000													75	110					0	0	1	0	0
RPS19	6223	broad.mit.edu	37	19	42373788	42373788	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:42373788C>T	ENST00000598742.1	+	5	748	c.376C>T	c.(376-378)Cag>Tag	p.Q126*	RPS19_ENST00000593863.1_Nonsense_Mutation_p.Q126*|RPS19_ENST00000221975.2_Nonsense_Mutation_p.Q52*	NM_001022.3	NP_001013.1	P39019	RS19_HUMAN	ribosomal protein S19	126					endocrine pancreas development|erythrocyte differentiation|gas transport|positive regulation of cellular component movement|response to extracellular stimulus|ribosomal small subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleolus	protein binding|RNA binding|structural constituent of ribosome	p.Q126*(1)		endometrium(1)|lung(1)|upper_aerodigestive_tract(1)	3						ACTGACACCTCAGGGACAAAG	0.617000									Diamond-Blackfan Anemia				7	41					0	0	1	0	0
CWH43	80157	broad.mit.edu	37	4	49032967	49032967	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr4:49032967C>T	ENST00000226432.4	+	11	1681	c.1498C>T	c.(1498-1500)Cac>Tac	p.H500Y	CWH43_ENST00000513409.1_Missense_Mutation_p.H473Y	NM_025087.2	NP_079363.2	Q9H720	PG2IP_HUMAN	cell wall biogenesis 43 C-terminal homolog (S. cerevisiae)	500					GPI anchor biosynthetic process	integral to membrane				cervix(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(26)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	43						CACAAGGTATCACACTTGGGG	0.443000													22	46					0	0	1	0	0
DDX27	55661	broad.mit.edu	37	20	47839804	47839804	+	Splice_Site	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr20:47839804G>A	ENST00000371764.4	+	4	402		c.e4-1		DDX27_ENST00000484427.1_Splice_Site	NM_017895.7	NP_060365.7	Q96GQ7	DDX27_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 27							nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(12)|lung(19)|ovary(1)|prostate(2)|skin(3)|urinary_tract(1)	45			BRCA - Breast invasive adenocarcinoma(12;0.000899)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			TTTTTTCCCAGGATAAAGAAG	0.458000													13	18					0	0	1	0	0
RAP2A	5911	broad.mit.edu	37	13	98086979	98086979	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr13:98086979C>T	ENST00000245304.4	+	1	504	c.255C>T	c.(253-255)gtC>gtT	p.V85V		NM_021033.6	NP_066361.1	P10114	RAP2A_HUMAN	RAP2A, member of RAS oncogene family	85					actin cytoskeleton reorganization|cellular protein localization|establishment of protein localization|positive regulation of protein autophosphorylation|Rap protein signal transduction|regulation of dendrite morphogenesis|regulation of JNK cascade	recycling endosome membrane	GTP binding|GTPase activity|protein binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	5	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.166)			ACAGCCTCGTCAACCAGCAGA	0.642000													12	44					0	0	1	0	0
PRG4	10216	broad.mit.edu	37	1	186275982	186275982	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:186275982C>T	ENST00000445192.2	+	7	1176	c.1131C>T	c.(1129-1131)acC>acT	p.T377T	PRG4_ENST00000367486.3_Silent_p.T334T|PRG4_ENST00000367483.4_Silent_p.T336T|PRG4_ENST00000367484.3_Silent_p.T336T|PRG4_ENST00000367485.4_Silent_p.T284T	NM_005807.3	NP_005798.2	Q92954	PRG4_HUMAN	proteoglycan 4	377	59 X 8 AA repeats of K-X-P-X-P-T-T-X.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(33)|prostate(7)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	102						CACCCACCACCCCCAAGGAGC	0.637000													4	129					0	0	1	0	0
FOXG1	2290	broad.mit.edu	37	14	29237361	29237361	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr14:29237361C>T	ENST00000382535.3	+	2	1245	c.876C>T	c.(874-876)ctC>ctT	p.L292L	FOXG1_ENST00000313071.4_Silent_p.L292L			P55316	FOXG1_HUMAN	forkhead box G1	292					axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(23)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(2)	43			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)		GTGCGCGCCTCACCTCCACCG	0.706000													41	37					0	0	1	0	0
SLC12A9	56996	broad.mit.edu	37	7	100457579	100457579	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr7:100457579C>G	ENST00000354161.3	+	8	1175	c.1050C>G	c.(1048-1050)atC>atG	p.I350M	SLC12A9_ENST00000415287.1_Missense_Mutation_p.I261M|SLC12A9_ENST00000475623.1_3'UTR|SLC12A9_ENST00000275729.3_Missense_Mutation_p.I261M|SLC12A9_ENST00000540482.1_Missense_Mutation_p.I350M|SLC12A9_ENST00000428758.1_Missense_Mutation_p.I350M	NM_020246.3	NP_064631.2	Q9BXP2	S12A9_HUMAN	solute carrier family 12, member 9	350						integral to membrane|plasma membrane	cation:chloride symporter activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(10)|lung(20)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	41	Lung NSC(181;0.041)|all_lung(186;0.0581)					TGATCGGAATCTATGCCACAG	0.602000													30	63					0	0	1	0	0
RPGR	6103	broad.mit.edu	37	X	38146396	38146396	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chrX:38146396C>G	ENST00000378505.2	-	15	2032	c.1856G>C	c.(1855-1857)aGa>aCa	p.R619T	RPGR_ENST00000339363.3_Missense_Mutation_p.R824T|RPGR_ENST00000309513.3_Missense_Mutation_p.R557T|RPGR_ENST00000342811.3_Missense_Mutation_p.R619T|RPGR_ENST00000318842.7_Missense_Mutation_p.R619T|TM4SF2_ENST00000465127.1_Intron|RPGR_ENST00000338898.3_3'UTR	NM_001034853.1	NP_001030025.1	Q92834	RPGR_HUMAN	retinitis pigmentosa GTPase regulator	619	Glu-rich.				intracellular protein transport|response to stimulus|visual perception	Golgi apparatus|photoreceptor outer segment	guanyl-nucleotide exchange factor activity|protein binding	p.R619T(2)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	25						Tttctcctttcttcctccatg	0.463000													34	38					0	0	1	0	0
FAM221B	392307	broad.mit.edu	37	9	35825915	35825915	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr9:35825915C>T	ENST00000423537.2	-	2	513	c.244G>A	c.(244-246)Gag>Aag	p.E82K	TMEM8B_ENST00000377996.1_Intron	NM_001012446.3	NP_001012448.2	A6H8Z2	CI128_HUMAN	family with sequence similarity 221, member B	82										endometrium(2)|kidney(1)|lung(4)	7						GAAGGAGTCTCAGAGATGGAA	0.532000											OREG0019180	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	35	209					0	0	1	0	0
EP300	2033	broad.mit.edu	37	22	41569739	41569739	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr22:41569739C>T	ENST00000263253.7	+	29	5949	c.4730C>T	c.(4729-4731)tCt>tTt	p.S1577F	RP1-85F18.6_ENST00000415054.1_RNA	NM_001429.3	NP_001420.2	Q09472	EP300_HUMAN	E1A binding protein p300	1577	Binding region for E1A adenovirus.				apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			NS(2)|breast(11)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(31)|kidney(5)|large_intestine(31)|liver(2)|lung(33)|ovary(2)|pancreas(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(16)	171						CCCAATGTATCTAACGACCTC	0.443000			"""T,  N, F, Mis, O"""	"""MLL, RUNXBP2"""	"""colorectal, breast, pancreatic, AML, ALL, DLBCL"""				Rubinstein-Taybi syndrome				48	99					0	0	1	0	0
TF	7018	broad.mit.edu	37	3	133475801	133475801	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:133475801G>A	ENST00000402696.3	+	7	1303	c.818G>A	c.(817-819)cGa>cAa	p.R273Q	TF_ENST00000264998.3_Missense_Mutation_p.R146Q	NM_001063.3	NP_001054	P02787	TRFE_HUMAN	transferrin	273	Transferrin-like 1.				cellular iron ion homeostasis|platelet activation|platelet degranulation|transferrin transport|transmembrane transport	apical plasma membrane|basal plasma membrane|coated pit|early endosome|endocytic vesicle|endosome membrane|extracellular region|late endosome|perinuclear region of cytoplasm|recycling endosome|stored secretory granule	ferric iron binding			NS(1)|autonomic_ganglia(1)|breast(3)|endometrium(7)|large_intestine(13)|liver(2)|lung(16)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	49					Aluminium(DB01370)|Bismuth(DB01402)|Iron Dextran(DB00893)	GTCGTGGCCCGAAGTATGGGC	0.592000													22	89					0	0	1	0	0
MAP10	54627	broad.mit.edu	37	1	232943184	232943184	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:232943184A>T	ENST00000418460.1	+	1	2542	c.2415A>T	c.(2413-2415)gaA>gaT	p.E805D		NM_019090.2	NP_061963.2			microtubule-associated protein 10																		TAGATAAGGAAATAGATATTA	0.353000													34	27					0	0	1	0	0
IL12RB2	3595	broad.mit.edu	37	1	67795343	67795343	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:67795343G>A	ENST00000262345.1	+	6	1378	c.738G>A	c.(736-738)tgG>tgA	p.W246*	IL12RB2_ENST00000544434.1_Nonsense_Mutation_p.W246*|IL12RB2_ENST00000371000.1_Nonsense_Mutation_p.W246*|IL12RB2_ENST00000541374.1_Nonsense_Mutation_p.W246*	NM_001559.2	NP_001550.1	Q99665	I12R2_HUMAN	interleukin 12 receptor, beta 2	246	Fibronectin type-III 2.				positive regulation of cell proliferation|positive regulation of interferon-gamma production	integral to plasma membrane	cytokine receptor activity			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(8)|lung(21)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	45						CCCTTTATTGGAGAGATGAGG	0.428000													18	37					0	0	1	0	0
RBP4	5950	broad.mit.edu	37	10	95360732	95360732	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr10:95360732C>T	ENST00000371467.1	-	2	373	c.54G>A	c.(52-54)gcG>gcA	p.A18A	FFAR4_ENST00000604414.1_Intron|RBP4_ENST00000371469.2_Intron|RBP4_ENST00000371464.3_Silent_p.A18A			P02753	RET4_HUMAN	retinol binding protein 4, plasma	18					cardiac muscle tissue development|embryonic organ morphogenesis|embryonic retina morphogenesis in camera-type eye|embryonic skeletal system development|female genitalia morphogenesis|gluconeogenesis|glucose homeostasis|heart trabecula formation|lung development|maintenance of gastrointestinal epithelium|negative regulation of cardiac muscle cell proliferation|positive regulation of immunoglobulin secretion|positive regulation of insulin secretion|response to retinoic acid|retinol metabolic process|urinary bladder development|uterus development|vagina development	extracellular space	protein binding|retinal binding|retinol binding			large_intestine(1)|lung(3)|skin(1)	5		Colorectal(252;0.122)			Vitamin A(DB00162)	AGTCGCGCTCCGCGCGGCCGC	0.701000													9	26					0	0	1	0	0
TWF2	11344	broad.mit.edu	37	3	52263176	52263176	+	Silent	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:52263176G>C	ENST00000305533.5	-	9	1167	c.924C>G	c.(922-924)ctC>ctG	p.L308L	TLR9_ENST00000597542.1_Intron|TLR9_ENST00000494383.1_Intron|TWF2_ENST00000499914.2_3'UTR	NM_007284.3	NP_009215.1			twinfilin actin-binding protein 2											breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|stomach(1)|urinary_tract(1)	15				BRCA - Breast invasive adenocarcinoma(193;2.43e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		CCTCGTCGTAGAGGAACTCTG	0.647000													18	53					0	0	1	0	0
RNF150	57484	broad.mit.edu	37	4	141789490	141789490	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr4:141789490C>T	ENST00000515673.2	-	7	1275	c.1242G>A	c.(1240-1242)ttG>ttA	p.L414L	RNF150_ENST00000306799.3_Silent_p.L372L|RNF150_ENST00000379512.2_Silent_p.L273L|RNF150_ENST00000420921.2_Silent_p.L273L			Q9ULK6	RN150_HUMAN	ring finger protein 150							integral to membrane	zinc ion binding			breast(1)|large_intestine(10)|lung(7)|ovary(1)	19	all_hematologic(180;0.162)					TTGCCATGATCAAGGAAATGT	0.463000													12	27					0	0	1	0	0
IPO9	55705	broad.mit.edu	37	1	201843488	201843488	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:201843488G>C	ENST00000361565.4	+	21	2890	c.2821G>C	c.(2821-2823)Gag>Cag	p.E941Q		NM_018085.4	NP_060555.2	Q96P70	IPO9_HUMAN	importin 9	941					protein import into nucleus	cytoplasm|nucleus	histone binding|protein transporter activity			cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(16)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	38						CACTCCTGCAGAGTGGAGTCA	0.493000													17	51					0	0	1	0	0
TJP2	9414	broad.mit.edu	37	9	71842693	71842693	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr9:71842693T>C	ENST00000377245.4	+	8	1431	c.1223T>C	c.(1222-1224)aTa>aCa	p.I408T	TJP2_ENST00000453658.2_Missense_Mutation_p.I385T|TJP2_ENST00000348208.4_Missense_Mutation_p.I408T|TJP2_ENST00000539225.1_Missense_Mutation_p.I439T|TJP2_ENST00000535702.1_Missense_Mutation_p.I412T|TJP2_ENST00000265384.7_Missense_Mutation_p.I408T	NM_004817.3	NP_004808.2	Q9UDY2	ZO2_HUMAN	tight junction protein 2	408					cellular component disassembly involved in apoptosis	adherens junction|cytoplasm|nucleus|tight junction	guanylate kinase activity|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(5)|lung(9)|prostate(3)|skin(3)|soft_tissue(1)|upper_aerodigestive_tract(1)	35						ATTTCAGAAATAGAGTCAAAC	0.333000													7	28					0	0	1	0	0
CACNA1D	776	broad.mit.edu	37	3	53839034	53839034	+	Silent	SNP	A	A	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:53839034A>G	ENST00000288139.4	+	46	5788	c.5670A>G	c.(5668-5670)agA>agG	p.R1890R	CACNA1D_ENST00000350061.5_Silent_p.R1870R|CACNA1D_ENST00000544977.1_Silent_p.R249R|CACNA1D_ENST00000422281.2_Silent_p.R1846R	NM_000720.2	NP_000711.1	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type, alpha 1D subunit						axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			breast(3)|central_nervous_system(9)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(13)|liver(1)|lung(29)|ovary(6)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	90				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	ACTACAGCAGATACCCAGGCA	0.527000													17	48					0	0	1	0	0
CTNNAL1	8727	broad.mit.edu	37	9	111745482	111745482	+	Silent	SNP	C	C	T	rs151311247	byFrequency	TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr9:111745482C>T	ENST00000374595.4	-	6	922	c.843G>A	c.(841-843)ccG>ccA	p.P281P	CTNNAL1_ENST00000325551.4_Silent_p.P281P|CTNNAL1_ENST00000325580.6_Silent_p.P281P			Q9UBT7	CTNL1_HUMAN	catenin (cadherin-associated protein), alpha-like 1	281					cell adhesion|Rho protein signal transduction	actin cytoskeleton|cytosol|plasma membrane	cadherin binding|structural molecule activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(5)|ovary(1)|prostate(4)|urinary_tract(2)	25				STAD - Stomach adenocarcinoma(157;0.0768)		TCTCTCCATTCGGTTTACAGT	0.328000													11	35					0	0	1	0	0
ITPR1	3708	broad.mit.edu	37	3	4878522	4878522	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:4878522G>T	ENST00000354582.6	+	60	8398	c.8048G>T	c.(8047-8049)gGa>gTa	p.G2683V	AC018816.3_ENST00000441894.1_Intron|ITPR1_ENST00000423119.2_Missense_Mutation_p.G2650V|ITPR1_ENST00000544951.1_Missense_Mutation_p.G661V|ITPR1_ENST00000456211.2_Missense_Mutation_p.G2635V|ITPR1_ENST00000357086.4_Missense_Mutation_p.G2650V|ITPR1_ENST00000463980.1_3'UTR|AC018816.3_ENST00000449914.1_Intron|ITPR1_ENST00000302640.8_Missense_Mutation_p.G2683V|ITPR1_ENST00000443694.2_Missense_Mutation_p.G2683V			Q14643	ITPR1_HUMAN	inositol 1,4,5-trisphosphate receptor, type 1	2698					activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(10)|endometrium(15)|kidney(6)|large_intestine(27)|liver(1)|lung(27)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(2)	106				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		GATTCTGAAGGAGAACAGAAT	0.423000													4	14					3.59834e-05	3.71367e-05	1	1	0
CPXM1	56265	broad.mit.edu	37	20	2776955	2776955	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr20:2776955C>T	ENST00000380605.2	-	9	1244	c.1180G>A	c.(1180-1182)Gag>Aag	p.E394K		NM_001184699.1|NM_019609.4	NP_001171628.1|NP_062555.1	Q96SM3	CPXM1_HUMAN	carboxypeptidase X (M14 family), member 1	394					cell adhesion|proteolysis		metallocarboxypeptidase activity|zinc ion binding			endometrium(5)|kidney(5)|large_intestine(8)|lung(17)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	43						ATGCGCATCTCAGAGAGCAGC	0.622000													24	51					0	0	1	0	0
TMEM67	91147	broad.mit.edu	37	8	94808186	94808186	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr8:94808186A>T	ENST00000453321.3	+	18	1889	c.1831A>T	c.(1831-1833)Act>Tct	p.T611S	TMEM67_ENST00000409623.3_Missense_Mutation_p.T530S	NM_153704.5	NP_714915.3	Q5HYA8	MKS3_HUMAN	transmembrane protein 67	611					cilium assembly|ER-associated protein catabolic process|negative regulation of centrosome duplication	centrosome|cilium membrane|cytoplasmic vesicle membrane|endoplasmic reticulum membrane|integral to membrane|microtubule basal body	unfolded protein binding			breast(3)|endometrium(8)|kidney(5)|large_intestine(4)|liver(2)|lung(15)|ovary(2)|skin(1)|urinary_tract(1)	41	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.00896)			ACGTTTTGTCACTTATGTTGG	0.333000													18	42					0	0	1	0	0
HNRNPA3	220988	broad.mit.edu	37	2	178080608	178080608	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:178080608G>C	ENST00000411529.2	+	3	311	c.260G>C	c.(259-261)aGa>aCa	p.R87T	HNRNPA3_ENST00000392524.2_Missense_Mutation_p.R109T|HNRNPA3_ENST00000435711.1_Missense_Mutation_p.R109T	NM_194247.2	NP_919223.1	P51991	ROA3_HUMAN	heterogeneous nuclear ribonucleoprotein A3	109	RRM 1.					catalytic step 2 spliceosome|nucleolus|nucleoplasm	nucleotide binding|protein binding|RNA binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|urinary_tract(1)	16						GAACCAAAGAGAGCTGTTTCT	0.368000													22	65					0	0	1	0	0
IMPG2	50939	broad.mit.edu	37	3	101038590	101038590	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:101038590G>C	ENST00000193391.7	-	2	359	c.172C>G	c.(172-174)Cta>Gta	p.L58V		NM_016247.3	NP_057331.2	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	58					visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			NS(1)|breast(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(14)|lung(32)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	64						TTGGTAGCTAGAGAAAGGTCT	0.423000													17	111					0	0	1	0	0
ST18	9705	broad.mit.edu	37	8	53084641	53084641	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr8:53084641C>T	ENST00000276480.7	-	10	1463	c.780G>A	c.(778-780)caG>caA	p.Q260Q		NM_014682.2	NP_055497.1	O60284	ST18_HUMAN	suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)	260						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(14)|lung(38)|ovary(4)|prostate(2)|skin(11)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	85		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				CGAGAGCATTCTGCGGGTCTT	0.473000													22	40					0	0	1	0	0
IPO9	55705	broad.mit.edu	37	1	201844282	201844282	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:201844282G>A	ENST00000361565.4	+	23	3010	c.2941G>A	c.(2941-2943)Gag>Aag	p.E981K		NM_018085.4	NP_060555.2	Q96P70	IPO9_HUMAN	importin 9	981					protein import into nucleus	cytoplasm|nucleus	histone binding|protein transporter activity			cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(16)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	38						TCTAACAGAGGAGGATTACTA	0.512000													18	67					0	0	1	0	0
TCHP	84260	broad.mit.edu	37	12	110345389	110345389	+	Missense_Mutation	SNP	G	G	A	rs140118187		TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr12:110345389G>A	ENST00000312777.5	+	6	798	c.584G>A	c.(583-585)cGa>cAa	p.R195Q	TCHP_ENST00000405876.4_Missense_Mutation_p.R195Q	NM_032300.4	NP_115676.1	Q9BT92	TCHP_HUMAN	trichoplein, keratin filament binding	195	Glu-rich.|Interaction with keratin proteins.				apoptosis|negative regulation of cell growth	apical cortex|centrosome|keratin filament|mitochondrion|plasma membrane	protein binding	p.R195Q(1)		NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|ovary(1)|skin(2)	22						GAAAGGGCCCGAAGGGAGGCG	0.517000													19	79					0	0	1	0	0
DGKG	1608	broad.mit.edu	37	3	185997708	185997708	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:185997708G>A	ENST00000265022.3	-	9	1263	c.724C>T	c.(724-726)Cta>Tta	p.L242L	DGKG_ENST00000382164.4_Silent_p.L242L|DGKG_ENST00000544847.1_Silent_p.L242L|DGKG_ENST00000344484.4_Silent_p.L242L	NM_001080744.1|NM_001080745.1|NM_001346.2	NP_001074213.1|NP_001074214.1|NP_001337.2	P49619	DGKG_HUMAN	diacylglycerol kinase, gamma 90kDa	242	EF-hand 2.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	42	all_cancers(143;3.26e-12)|Ovarian(172;0.0315)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)	GBM - Glioblastoma multiforme(93;0.0657)	Phosphatidylserine(DB00144)	CATTCCTGTAGAGACACAAAG	0.493000													42	125					0	0	1	0	0
ATG2B	55102	broad.mit.edu	37	14	96770887	96770887	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr14:96770887A>G	ENST00000359933.4	-	32	5680	c.4787T>C	c.(4786-4788)gTa>gCa	p.V1596A	ATG2B_ENST00000261834.5_5'UTR	NM_018036.5	NP_060506	Q96BY7	ATG2B_HUMAN	autophagy related 2B	1596										breast(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(11)|liver(1)|lung(26)|ovary(1)|prostate(1)|skin(1)|urinary_tract(7)	64		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		TCCCCCACATACTGTATTACG	0.378000													72	26					0	0	1	0	0
KIAA1614	57710	broad.mit.edu	37	1	180907837	180907837	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:180907837G>A	ENST00000367588.4	+	6	2963	c.2908G>A	c.(2908-2910)Gtg>Atg	p.V970M	KIAA1614_ENST00000367587.1_Missense_Mutation_p.V591M	NM_020950.1	NP_066001.1	Q5VZ46	K1614_HUMAN	KIAA1614	970	Ser-rich.									NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(12)|ovary(5)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	33						TGGAGGACATGTGCTGTCAAG	0.592000													10	18					0	0	1	0	0
IFT172	26160	broad.mit.edu	37	2	27703989	27703989	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:27703989C>T	ENST00000260570.3	-	8	812	c.709G>A	c.(709-711)Gac>Aac	p.D237N	IFT172_ENST00000359466.6_Missense_Mutation_p.D237N|IFT172_ENST00000416524.2_Missense_Mutation_p.D216N	NM_015662.1	NP_056477.1	Q9UG01	IF172_HUMAN	intraflagellar transport 172 homolog (Chlamydomonas)	237					cilium assembly	cilium	binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(17)|lung(17)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	43	Acute lymphoblastic leukemia(172;0.155)					TCCTGAGGGTCACGGCTATAA	0.493000													9	43					0	0	1	0	0
MRPL53	116540	broad.mit.edu	37	2	74699739	74699739	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:74699739G>A	ENST00000258105.7	-	1	710	c.49C>T	c.(49-51)Cgg>Tgg	p.R17W	MRPL53_ENST00000409710.1_Missense_Mutation_p.R17W	NM_053050.4	NP_444278.1	Q96EL3	RM53_HUMAN	mitochondrial ribosomal protein L53	17						mitochondrion|ribosome				central_nervous_system(1)|large_intestine(2)|lung(1)|urinary_tract(1)	5						AACTGAACCCGAACCTGTTTG	0.607000													21	70					0	0	1	0	0
TMEM132E	124842	broad.mit.edu	37	17	32963157	32963157	+	Silent	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr17:32963157G>C	ENST00000321639.5	+	9	2167	c.1839G>C	c.(1837-1839)ggG>ggC	p.G613G		NM_207313.1	NP_997196.1	Q6IEE7	T132E_HUMAN	transmembrane protein 132E	613						integral to membrane				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(28)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	57				BRCA - Breast invasive adenocarcinoma(366;0.231)		CCAGCCCTGGGAGCAGCCACA	0.642000													4	24					0	0	1	0	0
ARHGAP31	57514	broad.mit.edu	37	3	119128351	119128351	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:119128351C>G	ENST00000264245.4	+	11	2186	c.1654C>G	c.(1654-1656)Cct>Gct	p.P552A		NM_020754.2	NP_065805.2	Q2M1Z3	RHG31_HUMAN	Rho GTPase activating protein 31	552					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(3)|large_intestine(11)|lung(29)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	67						AGCTTCTGTACCTAAGAAGGC	0.532000													5	34					0	0	1	0	0
CPXM1	56265	broad.mit.edu	37	20	2777023	2777023	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr20:2777023A>G	ENST00000380605.2	-	9	1176	c.1112T>C	c.(1111-1113)cTg>cCg	p.L371P		NM_001184699.1|NM_019609.4	NP_001171628.1|NP_062555.1	Q96SM3	CPXM1_HUMAN	carboxypeptidase X (M14 family), member 1	371	Poly-Leu.				cell adhesion|proteolysis		metallocarboxypeptidase activity|zinc ion binding			endometrium(5)|kidney(5)|large_intestine(8)|lung(17)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	43						CATCAGGAGCAGAAGCAACTC	0.637000													21	68					0	0	1	0	0
LPO	4025	broad.mit.edu	37	17	56327796	56327796	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr17:56327796G>T	ENST00000262290.4	+	7	910	c.594G>T	c.(592-594)aaG>aaT	p.K198N	LPO_ENST00000421678.2_Missense_Mutation_p.K115N|LPO_ENST00000582328.1_Missense_Mutation_p.K115N|LPO_ENST00000543544.1_Missense_Mutation_p.K139N	NM_006151.2	NP_006142.1	P22079	PERL_HUMAN	lactoperoxidase	198					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			breast(5)|cervix(1)|endometrium(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	30						TATCTAACAAGATTGTTGGCT	0.488000											OREG0024609	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	38					6.12954e-19	6.60104e-19	1	1	0
SIGLEC5	8778	broad.mit.edu	37	19	52115563	52115563	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:52115563G>C	ENST00000222107.4	-	9	1715	c.1577C>G	c.(1576-1578)tCt>tGt	p.S526C	SIGLEC5_ENST00000429354.3_Missense_Mutation_p.S526C|SIGLEC5_ENST00000599649.1_Missense_Mutation_p.S526C|SIGLEC5_ENST00000534261.2_Missense_Mutation_p.S526C|SIGLEC5_ENST00000570106.2_Missense_Mutation_p.S526C			O15389	SIGL5_HUMAN	sialic acid binding Ig-like lectin 5	526					cell adhesion	integral to membrane	sugar binding	p.S526Y(1)		NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|large_intestine(4)|lung(9)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	27		all_neural(266;0.0726)		GBM - Glioblastoma multiforme(134;0.00124)|OV - Ovarian serous cystadenocarcinoma(262;0.0218)		CTTCATCTCAGAAAAACTAAG	0.552000													74	56					0	0	1	0	0
THPO	7066	broad.mit.edu	37	3	184093744	184093744	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:184093744G>A	ENST00000204615.7	-	3	287	c.73C>T	c.(73-75)Cct>Tct	p.P25S	THPO_ENST00000445696.2_Missense_Mutation_p.P25S|THPO_ENST00000421442.2_Missense_Mutation_p.P25S|EIF2B5_ENST00000444495.1_Intron	NM_000460.2|NM_001177597.1|NM_001177598.1	NP_000451.1|NP_001171068.1|NP_001171069.1	P40225	TPO_HUMAN	thrombopoietin	25					cell proliferation|platelet activation	extracellular space	cytokine activity|growth factor activity|hormone activity			NS(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|skin(1)	16	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			CAAGCAGGAGGAGCCGGGCTG	0.517000													17	76					0	0	1	0	0
PI4KB	5298	broad.mit.edu	37	1	151288629	151288629	+	Nonsense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:151288629G>C	ENST00000368875.2	-	3	945	c.365C>G	c.(364-366)tCa>tGa	p.S122*	PI4KB_ENST00000368873.1_Nonsense_Mutation_p.S110*|PI4KB_ENST00000529142.1_Intron|PI4KB_ENST00000368872.1_Nonsense_Mutation_p.S110*|PI4KB_ENST00000271657.5_Nonsense_Mutation_p.S122*|PI4KB_ENST00000368874.4_Nonsense_Mutation_p.S110*	NM_002651.2	NP_002642.1	Q9UBF8	PI4KB_HUMAN	phosphatidylinositol 4-kinase, catalytic, beta	110					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|receptor-mediated endocytosis	endosome|Golgi apparatus|mitochondrial outer membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum membrane	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			breast(3)|endometrium(5)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	27	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			GGCTGTGCCTGAGGCCACAGC	0.542000													37	242					0	0	1	0	0
FOXD4	2298	broad.mit.edu	37	9	116894	116894	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr9:116894G>C	ENST00000382500.2	-	1	1523	c.1226C>G	c.(1225-1227)tCg>tGg	p.S409W		NM_207305.4	NP_997188.2	Q12950	FOXD4_HUMAN	forkhead box D4	409					axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(5)|large_intestine(2)|lung(3)|prostate(1)|skin(3)	14	all_lung(41;0.218)	all_cancers(5;0.0395)|Acute lymphoblastic leukemia(5;1.91e-07)|all_hematologic(5;1.95e-06)	Kidney(42;0.112)|KIRC - Kidney renal clear cell carcinoma(5;0.157)	all cancers(5;0.000704)|Lung(218;0.00755)|GBM - Glioblastoma multiforme(5;0.0149)|Epithelial(6;0.0154)		GGCGGCCAGCGATGTCAGCCC	0.701000													64	41					0	0	1	0	0
CCDC62	84660	broad.mit.edu	37	12	123290752	123290752	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr12:123290752G>A	ENST00000253079.6	+	10	2105	c.1761G>A	c.(1759-1761)ttG>ttA	p.L587L	CCDC62_ENST00000537566.1_Silent_p.L348L|CCDC62_ENST00000392440.2_Silent_p.L348L|CCDC62_ENST00000392441.4_Silent_p.L587L	NM_201435.4	NP_958843.2	Q6P9F0	CCD62_HUMAN	coiled-coil domain containing 62	587						cytoplasm|nucleus				breast(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|skin(1)|urinary_tract(1)	20	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.51e-06)|Epithelial(86;2.65e-05)|BRCA - Breast invasive adenocarcinoma(302;0.206)		AATCTGCCTTGAGAGAAGATG	0.358000													9	49					0	0	1	0	0
KDM5A	5927	broad.mit.edu	37	12	416230	416230	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr12:416230G>A	ENST00000399788.2	-	24	4318	c.3956C>T	c.(3955-3957)tCt>tTt	p.S1319F	KDM5A_ENST00000382815.4_Missense_Mutation_p.S1319F	NM_001042603.1	NP_001036068.1	P29375	KDM5A_HUMAN	lysine (K)-specific demethylase 5A	1319					chromatin modification|multicellular organismal development|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(29)|ovary(1)|prostate(5)|skin(6)|stomach(1)|urinary_tract(2)	77						GTTAAAAGCAGACTGCTGGAA	0.413000			T	NUP98	AML								19	57					0	0	1	0	0
DNAJA1	3301	broad.mit.edu	37	9	33026543	33026543	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr9:33026543G>C	ENST00000330899.4	+	2	244	c.61G>C	c.(61-63)Gaa>Caa	p.E21Q	DNAJA1_ENST00000544625.1_5'UTR|DNAJA1_ENST00000495015.1_Intron	NM_001539.2	NP_001530.1	P31689	DNJA1_HUMAN	DnaJ (Hsp40) homolog, subfamily A, member 1	21	J.				protein folding|response to heat|response to unfolded protein	membrane	ATP binding|heat shock protein binding|low-density lipoprotein particle receptor binding|metal ion binding|unfolded protein binding			large_intestine(2)|ovary(1)|skin(3)	6			LUSC - Lung squamous cell carcinoma(29;0.0227)	GBM - Glioblastoma multiforme(74;0.102)		TACTCAGGAAGAATTGAAAAA	0.388000													11	66					0	0	1	0	0
ANXA1	301	broad.mit.edu	37	9	75773674	75773674	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr9:75773674C>T	ENST00000376911.1	+	2	1012	c.130C>T	c.(130-132)Cca>Tca	p.P44S	ANXA1_ENST00000257497.6_Missense_Mutation_p.P44S			P04083	ANXA1_HUMAN	annexin A1	44					alpha-beta T cell differentiation|anti-apoptosis|cell surface receptor linked signaling pathway|cellular component movement|inflammatory response|keratinocyte differentiation|lipid metabolic process|peptide cross-linking|positive regulation of vesicle fusion	basolateral plasma membrane|cilium|cornified envelope|cytoplasm|extracellular region|nucleus	calcium ion binding|calcium-dependent phospholipid binding|phospholipase A2 inhibitor activity|protein binding, bridging|receptor binding|structural molecule activity			breast(1)|central_nervous_system(1)|large_intestine(1)|lung(5)	8		all_epithelial(88;2.54e-11)		OV - Ovarian serous cystadenocarcinoma(323;2.82e-06)|GBM - Glioblastoma multiforme(74;0.0325)	Alclometasone(DB00240)|Amcinonide(DB00288)|Beclomethasone(DB00394)|Betamethasone(DB00443)|Clobetasol(DB01013)|Clocortolone(DB00838)|Desonide(DB01260)|Desoximetasone(DB00547)|Dexamethasone(DB01234)|Diflorasone(DB00223)|Flumethasone Pivalate(DB00663)|Halobetasol Propionate(DB00596)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Loteprednol Etabonate(DB00873)|Methylprednisolone(DB00959)|Mometasone(DB00764)|Prednicarbate(DB01130)|Prednisone(DB00635)|Rimexolone(DB00896)|Triamcinolone(DB00620)	TACCTTCAATCCATCCTCGGA	0.448000													13	46					0	0	1	0	0
SCUBE1	80274	broad.mit.edu	37	22	43606971	43606971	+	Silent	SNP	G	G	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr22:43606971G>T	ENST00000360835.4	-	18	2466	c.2340C>A	c.(2338-2340)acC>acA	p.T780T		NM_173050.3	NP_766638.2	Q8IWY4	SCUB1_HUMAN	signal peptide, CUB domain, EGF-like 1						adult heart development|blood coagulation|endothelial cell differentiation|inflammatory response|post-embryonic development|protein homooligomerization	external side of plasma membrane|extracellular space|extrinsic to plasma membrane	calcium ion binding|identical protein binding|protein heterodimerization activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(4)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		all_neural(38;0.0414)|Ovarian(80;0.07)				AGTCTGTGCTGGTGTTGCCCG	0.627000													18	39					6.94344e-10	7.32245e-10	1	1	0
GCM2	9247	broad.mit.edu	37	6	10876753	10876753	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr6:10876753C>T	ENST00000379491.4	-	3	528	c.381G>A	c.(379-381)ttG>ttA	p.L127L	RP11-637O19.3_ENST00000480294.1_Intron|SYCP2L_ENST00000543878.1_Intron	NM_004752.3	NP_004743.1	O75603	GCM2_HUMAN	glial cells missing homolog 2 (Drosophila)	127					cellular calcium ion homeostasis|cellular phosphate ion homeostasis|parathyroid gland development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|sequence-specific DNA binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	30	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)				GACAAGGAATCAACTCCAAAG	0.502000													21	86					0	0	1	0	0
TYRO3	7301	broad.mit.edu	37	15	41862508	41862508	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr15:41862508C>G	ENST00000263798.3	+	11	1677	c.1453C>G	c.(1453-1455)Cga>Gga	p.R485G	TYRO3_ENST00000559066.1_Missense_Mutation_p.R440G	NM_006293.3	NP_006284.2	Q06418	TYRO3_HUMAN	TYRO3 protein tyrosine kinase	485						integral to plasma membrane	ATP binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity	p.R485R(1)|p.R477R(1)		central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(26)|ovary(3)|prostate(1)	43		all_cancers(109;7.33e-15)|all_epithelial(112;2.8e-12)|Lung NSC(122;3.48e-08)|all_lung(180;1.71e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.31e-18)|GBM - Glioblastoma multiforme(113;9.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.117)		GTCCTTCAATCGAGAAAGGCC	0.567000													31	35					0	0	1	0	0
KPNA5	3841	broad.mit.edu	37	6	117046958	117046958	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr6:117046958G>A	ENST00000368564.1	+	11	1192	c.1044G>A	c.(1042-1044)ttG>ttA	p.L348L	KPNA5_ENST00000356348.1_Silent_p.L348L			O15131	IMA5_HUMAN	karyopherin alpha 5 (importin alpha 6)	345	NLS binding site (minor) (By similarity).				NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding|protein transporter activity			breast(6)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0298)|all cancers(137;0.0461)|OV - Ovarian serous cystadenocarcinoma(136;0.0513)|Epithelial(106;0.212)		TACATTTATTGAGTAGCCCAA	0.343000													9	49					0	0	1	0	0
DPPA4	55211	broad.mit.edu	37	3	109056351	109056351	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:109056351G>T	ENST00000335658.6	-	1	68	c.14C>A	c.(13-15)tCc>tAc	p.S5Y	DPPA4_ENST00000478791.1_5'UTR	NM_018189.3	NP_060659.3	Q7L190	DPPA4_HUMAN	developmental pluripotency associated 4	5						nucleus	protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(17)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	25						AGAAGAAGCGGAGCCTCGCAA	0.498000													9	65					9.70103e-10	1.02194e-09	1	1	0
PPRC1	23082	broad.mit.edu	37	10	103899304	103899304	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr10:103899304G>A	ENST00000278070.2	+	5	1078	c.1039G>A	c.(1039-1041)Gag>Aag	p.E347K	PPRC1_ENST00000413464.2_Missense_Mutation_p.E347K	NM_015062.3	NP_055877.3	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator-related 1	347					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(10)|lung(19)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	56		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		CGTAGTGCTGGAGATTGTGGG	0.607000													37	124					0	0	1	0	0
IGHV1-18	28468	broad.mit.edu	37	14	106641816	106641816	+	RNA	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr14:106641816G>A	ENST00000390605.2	-	0	156																											TGAGGCCCCAGGCTTCTTCAC	0.587000													105	40					0	0	1	0	0
AQP7	364	broad.mit.edu	37	9	33385585	33385585	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr9:33385585C>A	ENST00000541274.1	-	5	859	c.410G>T	c.(409-411)gGg>gTg	p.G137V	AQP7_ENST00000537089.1_3'UTR|AQP7_ENST00000377425.4_Intron|AQP7_ENST00000539936.1_3'UTR			O14520	AQP7_HUMAN	aquaporin 7	0					excretion|generation of precursor metabolites and energy	cell-cell junction|cytoplasm|integral to plasma membrane	glycerol channel activity|water channel activity			NS(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(4)|skin(2)|stomach(1)	17			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.191)		CACCCCCCACCCCTCAACACA	0.602000													4	74					0.00116845	0.00118812	1	1	0
EHBP1	23301	broad.mit.edu	37	2	63175429	63175429	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:63175429G>A	ENST00000263991.5	+	14	2035	c.1553G>A	c.(1552-1554)cGa>cAa	p.R518Q	EHBP1_ENST00000354487.3_Missense_Mutation_p.R483Q|EHBP1_ENST00000405015.3_Missense_Mutation_p.R483Q|EHBP1_ENST00000405289.1_Missense_Mutation_p.R483Q|EHBP1_ENST00000431489.1_Missense_Mutation_p.R483Q	NM_015252.3	NP_056067.2	Q8NDI1	EHBP1_HUMAN	EH domain binding protein 1	518	CH.					cytoplasm|membrane				biliary_tract(1)|breast(3)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(8)|lung(22)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	47	Lung NSC(7;0.0951)|all_lung(7;0.169)		LUSC - Lung squamous cell carcinoma(7;7.74e-05)|Epithelial(17;0.189)			GGAATTTCCCGATTATTGGAA	0.338000													15	71					0	0	1	0	0
SULT1B1	27284	broad.mit.edu	37	4	70620790	70620790	+	Nonsense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr4:70620790G>C	ENST00000310613.3	-	2	443	c.146C>G	c.(145-147)tCa>tGa	p.S49*		NM_014465.3	NP_055280.2	O43704	ST1B1_HUMAN	sulfotransferase family, cytosolic, 1B, member 1						3'-phosphoadenosine 5'-phosphosulfate metabolic process|cellular biogenic amine metabolic process|flavonoid metabolic process|steroid metabolic process|sulfation|thyroid hormone metabolic process|xenobiotic metabolic process	cytosol				breast(1)|cervix(1)|endometrium(2)|large_intestine(4)|lung(14)|prostate(1)|upper_aerodigestive_tract(1)	24						GAACTCACCTGATTTAGGATA	0.383000													24	48					0	0	1	0	0
KCNAB1	7881	broad.mit.edu	37	3	156139409	156139409	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:156139409C>T	ENST00000302490.8	+	2	1097	c.226C>T	c.(226-228)Ctt>Ttt	p.L76F	KCNAB1_ENST00000490337.1_Missense_Mutation_p.L94F|KCNAB1_ENST00000471742.1_Missense_Mutation_p.L83F|KCNAB1_ENST00000389636.5_Missense_Mutation_p.L94F|KCNAB1_ENST00000389634.5_Missense_Mutation_p.L76F	NM_172159.3	NP_751891.1	Q14722	KCAB1_HUMAN	potassium voltage-gated channel, shaker-related subfamily, beta member 1	94						cytoplasm|integral to membrane	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	28			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			TTATAGGAATCTTGGAAAATC	0.463000													12	107					0	0	1	0	0
RASGEF1C	255426	broad.mit.edu	37	5	179564679	179564679	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr5:179564679G>C	ENST00000393371.2	-	2	507	c.211C>G	c.(211-213)Cgc>Ggc	p.R71G	RASGEF1C_ENST00000361132.4_Missense_Mutation_p.R71G			Q8N431	RGF1C_HUMAN	RasGEF domain family, member 1C	71	N-terminal Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity			breast(1)|kidney(2)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)|stomach(1)	12	all_cancers(89;3.44e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	all_cancers(40;0.0242)|Medulloblastoma(196;0.00498)|all_neural(177;0.0137)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ATGAAGAGGCGAGAGCTCAGC	0.642000													12	24					0	0	1	0	0
C21orf91	54149	broad.mit.edu	37	21	19190540	19190540	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr21:19190540G>C	ENST00000284881.4	-	2	186	c.96C>G	c.(94-96)ttC>ttG	p.F32L	C21orf91_ENST00000493464.1_5'UTR|C21orf91_ENST00000400559.3_Missense_Mutation_p.F32L|C21orf91_ENST00000400558.3_Missense_Mutation_p.F32L	NM_001100420.1|NM_017447.3	NP_001093890.1|NP_059143.3	Q9NYK6	EURL_HUMAN	chromosome 21 open reading frame 91	32										endometrium(2)|large_intestine(2)|lung(4)|ovary(1)	9				Epithelial(23;8.76e-05)|all cancers(11;0.000422)|OV - Ovarian serous cystadenocarcinoma(11;0.0107)|Lung(58;0.0129)|COAD - Colon adenocarcinoma(22;0.0303)|LUSC - Lung squamous cell carcinoma(23;0.0381)|Colorectal(24;0.0929)		AAATGTGGCAGAAGGAGAGTG	0.368000													7	33					0	0	1	0	0
CHD3	1107	broad.mit.edu	37	17	7812129	7812129	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr17:7812129C>T	ENST00000380358.4	+	36	5554	c.5553C>T	c.(5551-5553)ttC>ttT	p.F1851F	CHD3_ENST00000330494.7_Silent_p.F1792F|CHD3_ENST00000358181.4_Silent_p.F1758F	NM_001005271.2	NP_001005271.2	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	1792	Required for interaction with PCNT.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(11)|kidney(6)|large_intestine(13)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|urinary_tract(2)	65		Prostate(122;0.202)				AAAATAAGTTCCTGGCCCGGA	0.483000													23	68					0	0	1	0	0
C17orf62	79415	broad.mit.edu	37	17	80402441	80402441	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr17:80402441C>T	ENST00000437807.2	-	7	642	c.325G>A	c.(325-327)Gat>Aat	p.D109N	C17orf62_ENST00000585080.1_Missense_Mutation_p.D109N|C17orf62_ENST00000578919.1_Missense_Mutation_p.D109N|C17orf62_ENST00000577732.1_Missense_Mutation_p.D109N|C17orf62_ENST00000578913.1_Missense_Mutation_p.D109N|C17orf62_ENST00000585064.1_Missense_Mutation_p.D109N|C17orf62_ENST00000336995.7_5'UTR|C17orf62_ENST00000434650.2_Missense_Mutation_p.D95N|C17orf62_ENST00000577436.1_Missense_Mutation_p.D95N|C17orf62_ENST00000583617.1_Missense_Mutation_p.D109N|C17orf62_ENST00000342572.8_5'UTR|C17orf62_ENST00000306645.5_Missense_Mutation_p.D109N	NM_001193653.1|NM_001193657.1	NP_001180582.1|NP_001180586.1	Q9BQA9	CQ062_HUMAN	chromosome 17 open reading frame 62	109						integral to membrane	protein binding			breast(2)|large_intestine(2)|skin(2)|urinary_tract(2)	8	Breast(20;0.00106)|all_neural(118;0.0804)		OV - Ovarian serous cystadenocarcinoma(97;0.0143)|BRCA - Breast invasive adenocarcinoma(99;0.0369)			ACGCTCACATCACGGACATCA	0.662000													50	35					0	0	1	0	0
SUPT6H	6830	broad.mit.edu	37	17	27001402	27001402	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr17:27001402G>A	ENST00000314616.6	+	3	494	c.211G>A	c.(211-213)Gag>Aag	p.E71K	SUPT6H_ENST00000347486.4_Missense_Mutation_p.E71K	NM_003170.3	NP_003161.2	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog (S. cerevisiae)	71	Asp/Glu-rich.			DDDEDEGEEDEGS -> ATAPGHPKLSEGR (in Ref. 1; AAC50821).	chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			NS(4)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(15)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64	Lung NSC(42;0.00431)					GGAGGAGGATGAGGGCAGTGA	0.493000													7	28					0	0	1	0	0
MPI	4351	broad.mit.edu	37	15	75190015	75190015	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr15:75190015C>T	ENST00000352410.4	+	8	1283	c.1216C>T	c.(1216-1218)Ctg>Ttg	p.L406L	MPI_ENST00000566377.1_3'UTR|MPI_ENST00000323744.6_Silent_p.L345L|MPI_ENST00000563786.1_Silent_p.L386L|MPI_ENST00000535694.1_Silent_p.L356L			P34949	MPI_HUMAN	mannose phosphate isomerase	406					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	cytosol	mannose-6-phosphate isomerase activity|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|ovary(2)|upper_aerodigestive_tract(1)	9						GAGTGTCTCACTGAAGCTTAC	0.562000													18	54					0	0	1	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102496504	102496504	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr14:102496504G>A	ENST00000360184.4	+	51	9932	c.9768G>A	c.(9766-9768)atG>atA	p.M3256I		NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	3256	Stalk (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						TCTAGGTTATGAGCCAAGAAA	0.428000													27	21					0	0	1	0	0
SLC9A3	6550	broad.mit.edu	37	5	483444	483444	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr5:483444G>A	ENST00000264938.3	-	6	1095	c.1086C>T	c.(1084-1086)ttC>ttT	p.F362F	SLC9A3_ENST00000514375.1_Silent_p.F362F	NM_004174.2	NP_004165.2	P48764	SL9A3_HUMAN	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3	362						cell surface|integral to membrane	sodium:hydrogen antiporter activity			NS(2)|biliary_tract(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|liver(2)|lung(16)|prostate(3)|skin(2)|urinary_tract(1)	37			Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			AGGTCCAGATGAACGGGTTCA	0.637000													4	56					0	0	1	0	0
CENPU	79682	broad.mit.edu	37	4	185616478	185616478	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr4:185616478G>C	ENST00000281453.5	-	13	1291	c.1221C>G	c.(1219-1221)atC>atG	p.I407M		NM_024629.3	NP_078905.2	Q71F23	CENPU_HUMAN		407					CenH3-containing nucleosome assembly at centromere|interspecies interaction between organisms|mitotic prometaphase|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|condensed chromosome kinetochore|cytosol|nucleoplasm				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|stomach(1)	13		all_lung(41;7.57e-14)|Lung NSC(41;1.81e-13)|Hepatocellular(41;0.000519)|Colorectal(36;0.00172)|Renal(120;0.00988)|Prostate(90;0.0235)|all_neural(102;0.0299)|all_hematologic(60;0.0592)|Medulloblastoma(177;0.146)		all cancers(43;7.83e-28)|Epithelial(43;2.56e-24)|OV - Ovarian serous cystadenocarcinoma(60;4.5e-11)|Colorectal(24;3.27e-06)|STAD - Stomach adenocarcinoma(60;2.66e-05)|GBM - Glioblastoma multiforme(59;3.16e-05)|BRCA - Breast invasive adenocarcinoma(30;0.000252)|COAD - Colon adenocarcinoma(29;0.000512)|LUSC - Lung squamous cell carcinoma(40;0.01)|READ - Rectum adenocarcinoma(43;0.0419)		ACTGATGGTTGATATTTCGCA	0.403000													17	51					0	0	1	0	0
PYCARD	29108	broad.mit.edu	37	16	31213926	31213926	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr16:31213926G>T	ENST00000247470.9	-	1	387	c.86C>A	c.(85-87)tCg>tAg	p.S29*	PYCARD_ENST00000350605.4_Nonsense_Mutation_p.S29*|C16orf98_ENST00000561916.2_Missense_Mutation_p.R51L	NM_013258.4	NP_037390.2	Q9ULZ3	ASC_HUMAN	PYD and CARD domain containing	29	DAPIN.				induction of apoptosis|positive regulation of interleukin-1 beta secretion|positive regulation of NF-kappaB transcription factor activity|proteolysis|tumor necrosis factor-mediated signaling pathway	IkappaB kinase complex	caspase activator activity|cysteine-type endopeptidase activity|protein homodimerization activity|Pyrin domain binding			NS(1)|kidney(1)	2						CAGCGGCACCGACAGCAGCTT	0.677000													12	76					5.50884e-06	5.71594e-06	1	1	0
PCDHGC4	56098	broad.mit.edu	37	5	140866533	140866533	+	Nonsense_Mutation	SNP	T	T	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr5:140866533T>A	ENST00000306593.1	+	1	1793	c.1793T>A	c.(1792-1794)tTg>tAg	p.L598*	PCDHGB3_ENST00000576222.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA11_ENST00000518882.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB7_ENST00000398594.2_Intron|PCDHGC3_ENST00000308177.3_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA12_ENST00000252085.3_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGA11_ENST00000398587.2_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018928.2|NM_032406.1	NP_061751.1|NP_115782.1														NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(13)|lung(13)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	42			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTGTGGACTTGGATTCAGGT	0.582000													21	45					0	0	1	0	0
OR1L8	138881	broad.mit.edu	37	9	125330241	125330241	+	Silent	SNP	G	G	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr9:125330241G>T	ENST00000304865.2	-	1	597	c.516C>A	c.(514-516)tcC>tcA	p.S172S		NM_001004454.1	NP_001004454.1	Q8NGR8	OR1L8_HUMAN	olfactory receptor, family 1, subfamily L, member 8	172					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20						GGATAACATTGGAGTCACAGA	0.493000													16	43					6.31663e-08	6.6109e-08	1	1	0
ADD3	120	broad.mit.edu	37	10	111879036	111879036	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr10:111879036A>G	ENST00000277900.8	+	7	1150	c.785A>G	c.(784-786)tAt>tGt	p.Y262C	ADD3_ENST00000356080.4_Missense_Mutation_p.Y262C|ADD3_ENST00000360162.3_Missense_Mutation_p.Y262C	NM_001121.2	NP_001112.2	Q9UEY8	ADDG_HUMAN	adducin 3 (gamma)	262						cytoskeleton	actin binding|calmodulin binding|metal ion binding|structural constituent of cytoskeleton			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	29		Breast(234;0.052)|Lung NSC(174;0.223)		Epithelial(162;4.15e-05)|all cancers(201;0.000587)|BRCA - Breast invasive adenocarcinoma(275;0.0742)		GATGTTGCCTATTATGACTAC	0.428000													22	36					0	0	1	0	0
SIRT3	23410	broad.mit.edu	37	11	233208	233208	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr11:233208C>T	ENST00000382743.4	-	3	583	c.481G>A	c.(481-483)Ggg>Agg	p.G161R	SIRT3_ENST00000524564.1_Missense_Mutation_p.G97R|SIRT3_ENST00000529382.1_Missense_Mutation_p.G19R|SIRT3_ENST00000525319.1_Missense_Mutation_p.G80R|SIRT3_ENST00000528702.1_5'UTR|SIRT3_ENST00000532956.1_Missense_Mutation_p.G161R	NM_001017524.2|NM_012239.5	NP_001017524.1|NP_036371.1	Q9NTG7	SIRT3_HUMAN	sirtuin 3	161	Deacetylase sirtuin-type.				chromatin silencing|protein ADP-ribosylation|protein deacetylation	mitochondrial matrix	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|NAD+ ADP-ribosyltransferase activity|NAD+ binding|protein binding|zinc ion binding			endometrium(1)|lung(5)|urinary_tract(1)	7		all_cancers(49;1.58e-09)|all_epithelial(84;2.71e-06)|Breast(177;0.000162)|Ovarian(85;0.000626)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;3.66e-27)|Epithelial(43;2.02e-26)|OV - Ovarian serous cystadenocarcinoma(40;2.9e-21)|BRCA - Breast invasive adenocarcinoma(625;3.88e-05)|Lung(200;0.111)|LUSC - Lung squamous cell carcinoma(625;0.129)		AGGCCACTCCCCGGCGATCTG	0.567000													10	27					0	0	1	0	0
USP9Y	8287	broad.mit.edu	37	Y	14952353	14952353	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chrY:14952353G>A	ENST00000338981.3	+	36	6846	c.5901G>A	c.(5899-5901)atG>atA	p.M1967I	USP9Y_ENST00000426564.2_3'UTR	NM_004654.3	NP_004645.2	O00507	USP9Y_HUMAN	ubiquitin specific peptidase 9, Y-linked	1967					BMP signaling pathway|protein deubiquitination|spermatogenesis|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			kidney(1)|large_intestine(8)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						ATGATGAGATGATAAGATACA	0.373000													12	9					0	0	1	0	0
ZNF276	92822	broad.mit.edu	37	16	89799778	89799778	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr16:89799778C>A	ENST00000289816.5	+	7	1325	c.1013C>A	c.(1012-1014)cCg>cAg	p.P338Q	ZNF276_ENST00000446326.2_Missense_Mutation_p.P199Q|ZNF276_ENST00000443381.2_Missense_Mutation_p.P413Q|ZNF276_ENST00000568064.1_Missense_Mutation_p.P321Q	NM_152287.3	NP_689500.2	Q8N554	ZN276_HUMAN	zinc finger protein 276	413					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(6)|prostate(1)	14		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		CGGAAGAAGCCGGGACCCAAG	0.527000													78	36					1.16018e-38	1.26494e-38	1	1	0
TMPRSS7	344805	broad.mit.edu	37	3	111794194	111794194	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:111794194C>G	ENST00000452346.2	+	15	1813	c.1810C>G	c.(1810-1812)Cac>Gac	p.H604D	TMPRSS7_ENST00000419127.1_Missense_Mutation_p.H478D			Q7RTY8	TMPS7_HUMAN	transmembrane protease, serine 7	604					proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity			breast(2)|endometrium(6)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	34						CTCCGCCCTTCACCGCATCAT	0.537000													27	134					0	0	1	0	0
PTPLAD2	401494	broad.mit.edu	37	9	21015926	21015926	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr9:21015926G>A	ENST00000495827.2	-	4	399	c.354C>T	c.(352-354)ttC>ttT	p.F118F	PTPLAD2_ENST00000488436.1_5'UTR|PTPLAD2_ENST00000513293.2_Silent_p.F118F	NM_001010915.3	NP_001010915.2	Q5VWC8	HACD4_HUMAN	protein tyrosine phosphatase-like A domain containing 2						fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	lyase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|prostate(1)|skin(1)	10				Lung(24;6.02e-14)|LUSC - Lung squamous cell carcinoma(38;1.29e-10)		TCCAAAAGACGAATAAAACAC	0.363000													7	77					0	0	1	0	0
RHOJ	57381	broad.mit.edu	37	14	63671662	63671662	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr14:63671662G>A	ENST00000316754.3	+	1	537	c.75G>A	c.(73-75)gtG>gtA	p.V25V	RHOJ_ENST00000557133.1_3'UTR|RHOJ_ENST00000555125.1_Silent_p.V25V	NM_020663.4	NP_065714.1	Q9H4E5	RHOJ_HUMAN	ras homolog family member J	25					actin cytoskeleton organization|regulation of cell shape|regulation of small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding|GTPase activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|upper_aerodigestive_tract(1)	21				OV - Ovarian serous cystadenocarcinoma(108;0.00326)|all cancers(60;0.031)|BRCA - Breast invasive adenocarcinoma(234;0.119)		TGAAGTGTGTGGTGGTGGGGG	0.582000													23	16					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152528918	152528918	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:152528918C>T	ENST00000427231.2	-	37	4466	c.4264G>A	c.(4264-4266)Gag>Aag	p.E1422K	NEB_ENST00000604864.1_Missense_Mutation_p.E1422K|NEB_ENST00000603639.1_Missense_Mutation_p.E1422K|NEB_ENST00000409198.1_Missense_Mutation_p.E1422K|NEB_ENST00000172853.10_Missense_Mutation_p.E1422K|NEB_ENST00000397345.3_Missense_Mutation_p.E1422K	NM_001164507.1|NM_001271208.1	NP_001157979|NP_001258137.1	P20929	NEBU_HUMAN	nebulin	1422					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		CTCGTATGCTCAAGACTCATG	0.428000													11	30					0	0	1	0	0
INTS2	57508	broad.mit.edu	37	17	59989420	59989420	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr17:59989420G>T	ENST00000444766.3	-	6	760	c.685C>A	c.(685-687)Ctg>Atg	p.L229M	INTS2_ENST00000251334.6_Missense_Mutation_p.L221M	NM_020748.2	NP_065799	Q9H0H0	INT2_HUMAN	integrator complex subunit 2	229					snRNA processing	integral to membrane|integrator complex|nuclear membrane	protein binding			NS(1)|breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	38						TTTTTTATCAGGCCCCTACAA	0.408000													61	86					1.42676e-28	1.54686e-28	1	1	0
NUS1	116150	broad.mit.edu	37	6	118024866	118024866	+	Splice_Site	SNP	G	G	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr6:118024866G>T	ENST00000368494.3	+	4	959	c.790G>T	c.(790-792)Gtc>Ttc	p.V264F		NM_138459.3	NP_612468.1	Q96E22	NGBR_HUMAN	nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae)	264					angiogenesis|cell differentiation	integral to membrane	receptor activity|transferase activity, transferring alkyl or aryl (other than methyl) groups			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(1)|prostate(2)	8		all_cancers(87;0.0395)|all_epithelial(87;0.0301)		GBM - Glioblastoma multiforme(226;0.02)|OV - Ovarian serous cystadenocarcinoma(136;0.115)|all cancers(137;0.146)		GACTGAGATTGTGTAAGTAAT	0.398000													28	37					2.48779e-11	2.63221e-11	1	1	0
KIAA1432	57589	broad.mit.edu	37	9	5774178	5774178	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr9:5774178G>A	ENST00000414202.2	+	26	4395	c.4204G>A	c.(4204-4206)Gag>Aag	p.E1402K	KIAA1432_ENST00000418622.3_Missense_Mutation_p.E1323K|KIAA1432_ENST00000449720.2_Missense_Mutation_p.E1286K	NM_001206557.1|NM_020829.3	NP_001193486.1|NP_065880.2	Q4ADV7	RIC1_HUMAN	KIAA1432	1402						integral to membrane				breast(2)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(6)|lung(23)|prostate(1)|upper_aerodigestive_tract(1)	45		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		CCGGAAAGAGGAGGACACAGC	0.552000													20	84					0	0	1	0	0
B3GNT3	10331	broad.mit.edu	37	19	17918757	17918757	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:17918757G>A	ENST00000318683.6	+	2	288	c.141G>A	c.(139-141)ctG>ctA	p.L47L	B3GNT3_ENST00000595387.1_Silent_p.L47L	NM_014256.3	NP_055071.2	Q9Y2A9	B3GN3_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3	47					protein glycosylation	Golgi membrane|integral to plasma membrane	galactosyltransferase activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)	21						CCGAGGCCCTGGCCTGGCCCA	0.682000													6	24					0	0	1	0	0
NLRP14	338323	broad.mit.edu	37	11	7064634	7064634	+	Silent	SNP	T	T	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr11:7064634T>C	ENST00000299481.4	+	4	1723	c.1377T>C	c.(1375-1377)agT>agC	p.S459S		NM_176822.3	NP_789792.1	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	459	NACHT.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			breast(3)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	21				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		ATGTCTCTAGTTTTATGGACA	0.403000													26	34					0	0	1	0	0
DNAH12	201625	broad.mit.edu	37	3	57487120	57487120	+	Silent	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:57487120G>C	ENST00000351747.2	-	11	1443	c.1263C>G	c.(1261-1263)ctC>ctG	p.L421L	DNAH12_ENST00000311202.6_Silent_p.L421L|DNAH12_ENST00000389536.4_Silent_p.L421L	NM_178504.4	NP_848599.3	Q6ZR08	DYH12_HUMAN	dynein, axonemal, heavy chain 12	421	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity	p.L422F(2)		breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(4)|lung(7)|pancreas(1)|prostate(1)|skin(1)	25						TCCCATCAAGGAGCCAATTAT	0.279000													8	52					0	0	1	0	0
DKK4	27121	broad.mit.edu	37	8	42234537	42234537	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr8:42234537C>T	ENST00000220812.2	-	1	213	c.27G>A	c.(25-27)ctG>ctA	p.L9L		NM_014420.2	NP_055235.1	Q9UBT3	DKK4_HUMAN	dickkopf WNT signaling pathway inhibitor 4	9					multicellular organismal development|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular region				NS(1)|endometrium(1)|large_intestine(7)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	14	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;2.58e-12)|Lung NSC(13;4.24e-11)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.1)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;3.48e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00523)|Lung(22;0.00597)|LUSC - Lung squamous cell carcinoma(45;0.024)			AGAGCCAGCTCAGCCCCAGCA	0.642000													14	18					0	0	1	0	0
SMTNL1	219537	broad.mit.edu	37	11	57310113	57310113	+	Splice_Site	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr11:57310113G>C	ENST00000457912.1	+	2	52		c.e2-1		SMTNL1_ENST00000527972.1_5'Flank			E9PPJ3	E9PPJ3_HUMAN	smoothelin-like 1											endometrium(2)|large_intestine(1)|lung(4)|ovary(1)	8						TCTCTTTCCAGAGATGGAGCA	0.607000													10	22					0	0	1	0	0
ANKRD40	91369	broad.mit.edu	37	17	48777205	48777205	+	Silent	SNP	C	C	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr17:48777205C>A	ENST00000285243.6	-	3	602	c.333G>T	c.(331-333)ctG>ctT	p.L111L		NM_052855.3	NP_443087.1	Q6AI12	ANR40_HUMAN	ankyrin repeat domain 40	111										breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(2)|skin(1)|urinary_tract(1)	11			BRCA - Breast invasive adenocarcinoma(22;2.03e-09)			ACTCCTTCTTCAGCTGGGGGA	0.423000													17	22					9.16793e-09	9.6368e-09	1	1	0
SPTA1	6708	broad.mit.edu	37	1	158648216	158648216	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:158648216C>T	ENST00000368147.4	-	6	967	c.787G>A	c.(787-789)Gct>Act	p.A263T		NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)						actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					AAGTTTGCAGCATTGGACAGA	0.433000													18	96					0	0	1	0	0
PNKP	11284	broad.mit.edu	37	19	50367631	50367631	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:50367631G>A	ENST00000322344.3	-	5	637	c.528C>T	c.(526-528)ctC>ctT	p.L176L	PNKP_ENST00000600573.1_Silent_p.L176L|PNKP_ENST00000596014.1_Silent_p.L176L|PNKP_ENST00000600910.1_Silent_p.L176L	NM_007254.3	NP_009185.2	Q96T60	PNKP_HUMAN	polynucleotide kinase 3'-phosphatase	176			L -> F (in MCSZ).		DNA damage response, detection of DNA damage|DNA-dependent DNA replication|nucleotide-excision repair, DNA damage removal|response to oxidative stress|response to radiation	nucleolus	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|damaged DNA binding|double-stranded DNA binding|endonuclease activity|nucleotide kinase activity|polynucleotide 3'-phosphatase activity|protein binding			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(10)|ovary(1)|urinary_tract(1)	19		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0118)|OV - Ovarian serous cystadenocarcinoma(262;0.0134)		GTGTGGTGATGAGCGTCCCGT	0.567000								Other BER factors					35	81					0	0	1	0	0
HIST1H3B	8358	broad.mit.edu	37	6	26032069	26032069	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr6:26032069C>T	ENST00000244661.2	-	1	219	c.220G>A	c.(220-222)Gaa>Aaa	p.E74K		NM_003537.3	NP_003528.1	P68431	H31_HUMAN	histone cluster 1, H3b	74					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding	p.E74K(5)		breast(3)|central_nervous_system(10)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)|skin(1)	25						TGGGCGATTTCTCGCACCAGG	0.607000													43	128					0	0	1	0	0
GRAMD3	65983	broad.mit.edu	37	5	125828638	125828638	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr5:125828638A>G	ENST00000285689.3	+	14	1750	c.1289A>G	c.(1288-1290)aAt>aGt	p.N430S	GRAMD3_ENST00000515200.1_Missense_Mutation_p.N408S|GRAMD3_ENST00000542322.1_Missense_Mutation_p.N438S|GRAMD3_ENST00000513040.1_Missense_Mutation_p.N445S|GRAMD3_ENST00000544396.1_Missense_Mutation_p.N326S|GRAMD3_ENST00000502348.1_Missense_Mutation_p.N321S|GRAMD3_ENST00000511134.1_Missense_Mutation_p.N414S|GRAMD3_ENST00000543198.1_3'UTR	NM_023927.2	NP_076416.2	Q96HH9	GRAM3_HUMAN	GRAM domain containing 3	430										breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	11		Prostate(80;0.0928)	KIRC - Kidney renal clear cell carcinoma(527;0.0584)|Kidney(363;0.0934)	Epithelial(69;0.0401)|OV - Ovarian serous cystadenocarcinoma(64;0.0604)|all cancers(49;0.108)		TTGCTTGAGAATGGTGACTGA	0.378000													21	41					0	0	1	0	0
PUM1	9698	broad.mit.edu	37	1	31478736	31478736	+	Silent	SNP	T	T	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:31478736T>C	ENST00000373747.3	-	5	783	c.684A>G	c.(682-684)tcA>tcG	p.S228S	PUM1_ENST00000423018.2_Intron|PUM1_ENST00000426105.2_Silent_p.S228S|PUM1_ENST00000373741.4_Silent_p.S264S|PUM1_ENST00000257075.5_Silent_p.S228S|PUM1_ENST00000440538.2_Silent_p.S228S|PUM1_ENST00000424085.2_Intron|PUM1_ENST00000373742.2_Intron	NM_001020658.1	NP_001018494.1	Q14671	PUM1_HUMAN	pumilio RNA-binding family member 1	228					cellular membrane organization|post-Golgi vesicle-mediated transport|regulation of translation	cytosol	RNA binding			breast(1)|central_nervous_system(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(17)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	48		Colorectal(325;0.0211)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0381)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0232)|READ - Rectum adenocarcinoma(331;0.0681)		CGCCCGGGGATGAGCTCAACA	0.488000													12	33					0	0	1	0	0
TMPRSS4	56649	broad.mit.edu	37	11	117984006	117984006	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr11:117984006T>C	ENST00000534111.1	+	9	1025	c.760T>C	c.(760-762)Tgg>Cgg	p.W254R	TMPRSS4_ENST00000518413.2_3'UTR|TMPRSS4_ENST00000522824.1_Missense_Mutation_p.W251R|TMPRSS4_ENST00000523251.1_Missense_Mutation_p.W216R|TMPRSS4_ENST00000437212.3_Missense_Mutation_p.W256R|TMPRSS4_ENST00000522307.1_Missense_Mutation_p.W109R	NM_001083947.1|NM_001173551.1|NM_019894.3	NP_001077416.1|NP_001167022|NP_063947.1	Q9NRS4	TMPS4_HUMAN	transmembrane protease, serine 4	256	Peptidase S1.				proteolysis	integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			breast(2)|central_nervous_system(2)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)|skin(1)	19	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0431)|all_hematologic(192;0.164)|Breast(348;0.183)|all_neural(223;0.238)		BRCA - Breast invasive adenocarcinoma(274;4.16e-05)|Epithelial(105;0.00204)		TGTGTTCAACTGGAAGGTGCG	0.557000													75	89					0	0	1	0	0
ST3GAL1	6482	broad.mit.edu	37	8	134477050	134477050	+	Silent	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr8:134477050C>G	ENST00000319914.5	-	6	1681	c.654G>C	c.(652-654)gtG>gtC	p.V218V	ST3GAL1_ENST00000522652.1_Silent_p.V218V|ST3GAL1_ENST00000521180.1_Silent_p.V218V|ST3GAL1_ENST00000399640.2_Silent_p.V218V			Q11201	SIA4A_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	218					protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,3-sialyltransferase activity			endometrium(3)|large_intestine(2)|lung(11)|prostate(1)	17	all_epithelial(106;1.53e-23)|Lung NSC(106;3.15e-07)|all_lung(105;1.26e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.00721)			TGATGGCGCTCACCACCCACT	0.637000													28	51					0	0	1	0	0
SUPT6H	6830	broad.mit.edu	37	17	27001630	27001630	+	Splice_Site	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr17:27001630G>C	ENST00000314616.6	+	4	627	c.344G>C	c.(343-345)gGa>gCa	p.G115A	SUPT6H_ENST00000347486.4_Splice_Site_p.G115A	NM_003170.3	NP_003161.2	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog (S. cerevisiae)	115	Asp/Glu-rich.				chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			NS(4)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(15)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64	Lung NSC(42;0.00431)					GTCAAAAGAGGAGTAAGTGTC	0.458000													23	69					0	0	1	0	0
CPS1	1373	broad.mit.edu	37	2	211421493	211421493	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:211421493G>C	ENST00000233072.5	+	1	232	c.36G>C	c.(34-36)agG>agC	p.R12S	CPS1_ENST00000430249.2_Missense_Mutation_p.R18S	NM_001875.4	NP_001866.2	P31327	CPSM_HUMAN	carbamoyl-phosphate synthase 1, mitochondrial	12					carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(85)|ovary(8)|pancreas(1)|prostate(6)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	142				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		AAGTGGTGAGGACACTGAAGA	0.368000													7	43					0	0	1	0	0
SLC15A2	6565	broad.mit.edu	37	3	121647952	121647952	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:121647952C>G	ENST00000489711.1	+	16	1853	c.1465C>G	c.(1465-1467)Ctt>Gtt	p.L489V	SLC15A2_ENST00000465060.1_3'UTR|SLC15A2_ENST00000295605.2_Missense_Mutation_p.L458V	NM_021082.3	NP_066568.3	Q16348	S15A2_HUMAN	solute carrier family 15 (oligopeptide transporter), member 2	489					protein transport	integral to plasma membrane	peptide:hydrogen symporter activity|protein binding			NS(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(17)|skin(6)|upper_aerodigestive_tract(2)	36				GBM - Glioblastoma multiforme(114;0.0967)	Cefadroxil(DB01140)	CTGGTACAGTCTTGTCATTCG	0.408000													22	168					0	0	1	0	0
ATAD5	79915	broad.mit.edu	37	17	29162810	29162810	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr17:29162810G>A	ENST00000321990.4	+	2	2089	c.1711G>A	c.(1711-1713)Gat>Aat	p.D571N	CTD-2349P21.11_ENST00000580873.1_RNA	NM_024857.3	NP_079133.3	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	571					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(3)|large_intestine(18)|lung(13)|ovary(3)|pancreas(1)	51		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				ACCAGTTAAAGATATTAAGCT	0.368000													11	52					0	0	1	0	0
GPR133	283383	broad.mit.edu	37	12	131620621	131620621	+	Silent	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr12:131620621G>C	ENST00000261654.5	+	22	2866	c.2307G>C	c.(2305-2307)ctG>ctC	p.L769L	GPR133_ENST00000535015.1_Silent_p.L801L|GPR133_ENST00000540207.1_3'UTR|GPR133_ENST00000543617.1_Silent_p.L288L|GPR133_ENST00000376682.4_Silent_p.L455L	NM_198827.3	NP_942122.2	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133	769					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(2)|endometrium(6)|kidney(1)|large_intestine(12)|lung(20)|ovary(3)|pancreas(6)|prostate(6)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(4)	67	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		TGCCCATCCTGGGTACCTCGT	0.602000													17	29					0	0	1	0	0
TRRAP	8295	broad.mit.edu	37	7	98569460	98569460	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr7:98569460G>C	ENST00000359863.4	+	52	7919	c.7710G>C	c.(7708-7710)caG>caC	p.Q2570H	TRRAP_ENST00000355540.3_Missense_Mutation_p.Q2552H|TRRAP_ENST00000446306.3_Missense_Mutation_p.Q2552H	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	2570					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			CTGGGGATCAGACCAGCACGC	0.458000													62	133					0	0	1	0	0
PLEKHH2	130271	broad.mit.edu	37	2	43970992	43970992	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:43970992C>T	ENST00000282406.4	+	23	3529	c.3419C>T	c.(3418-3420)tCt>tTt	p.S1140F		NM_172069.3	NP_742066.2	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2	1140	FERM.					cytoplasm|cytoskeleton|integral to membrane	binding	p.S1140F(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(12)|lung(24)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	56		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				TTTGACGCATCTACCACAGTG	0.388000													5	51					0	0	1	0	0
LOH12CR1	118426	broad.mit.edu	37	12	12588569	12588569	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr12:12588569G>A	ENST00000314565.4	+	3	541	c.210G>A	c.(208-210)ttG>ttA	p.L70L	LOH12CR1_ENST00000542728.1_Silent_p.L51L|LOH12CR1_ENST00000298571.6_Silent_p.L22L	NM_058169.3	NP_477517.1	Q969J3	L12R1_HUMAN	loss of heterozygosity, 12, chromosomal region 1	70										kidney(1)|large_intestine(1)|lung(1)|ovary(1)	4		Prostate(47;0.0802)		BRCA - Breast invasive adenocarcinoma(232;0.0205)		AAGGGCTATTGAGTGGCCAGA	0.403000													27	78					0	0	1	0	0
KIAA1199	57214	broad.mit.edu	37	15	81235439	81235439	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr15:81235439G>C	ENST00000394685.3	+	28	4272	c.3853G>C	c.(3853-3855)Gac>Cac	p.D1285H	KIAA1199_ENST00000220244.3_Missense_Mutation_p.D1285H|RP11-351M8.2_ENST00000560873.1_RNA|KIAA1199_ENST00000356249.5_Missense_Mutation_p.D1285H			Q8WUJ3	K1199_HUMAN	KIAA1199	1285										breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(10)|lung(14)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	49						GACCATCCCTGACAAGTGAGT	0.572000													50	157					0	0	1	0	0
SKAP2	8935	broad.mit.edu	37	7	26709767	26709767	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr7:26709767G>A	ENST00000345317.2	-	12	1345	c.1032C>T	c.(1030-1032)gcC>gcT	p.A344A	SKAP2_ENST00000539623.1_Silent_p.A172A	NM_003930.3	NP_003921.2	O75563	SKAP2_HUMAN	src kinase associated phosphoprotein 2	344	SH3.				B cell activation|cell junction assembly|protein complex assembly|signal transduction	cytosol|plasma membrane	SH3/SH2 adaptor activity			haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)|skin(3)	17						CCAAGCCAATGGCTCCCTTCA	0.363000													9	29					0	0	1	0	0
TSPAN14	81619	broad.mit.edu	37	10	82269104	82269104	+	Silent	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr10:82269104C>G	ENST00000429989.3	+	5	550	c.327C>G	c.(325-327)gcC>gcG	p.A109A	TSPAN14_ENST00000372158.1_Silent_p.A109A|TSPAN14_ENST00000341863.6_Intron|TSPAN14_ENST00000372164.3_Silent_p.A92A|TSPAN14_ENST00000372156.1_Silent_p.A109A|TSPAN14_ENST00000481124.1_Intron	NM_030927.2	NP_112189.2	Q8NG11	TSN14_HUMAN	tetraspanin 14							integral to membrane				central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(1)|ovary(1)|skin(1)	7			Colorectal(32;0.229)			TGGCTGTGGCCGTGCTGGCCT	0.607000													19	29					0	0	1	0	0
CLHC1	130162	broad.mit.edu	37	2	55439866	55439866	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:55439866C>A	ENST00000401408.1	-	5	787	c.442G>T	c.(442-444)Gac>Tac	p.D148Y	CLHC1_ENST00000406076.1_Missense_Mutation_p.D26Y|CLHC1_ENST00000494539.1_Intron|CLHC1_ENST00000406437.2_Intron|CLHC1_ENST00000407122.1_Missense_Mutation_p.D148Y	NM_152385.2	NP_689598.2			clathrin heavy chain linker domain containing 1																		TCTTTTGTGTCATACTCTGCC	0.323000													6	24					8.12818e-05	8.34413e-05	1	1	0
C19orf44	84167	broad.mit.edu	37	19	16612042	16612042	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:16612042A>C	ENST00000221671.3	+	2	595	c.439A>C	c.(439-441)Aca>Cca	p.T147P	C19orf44_ENST00000594035.1_Missense_Mutation_p.T147P|CTD-3222D19.2_ENST00000409035.1_Intron	NM_032207.2	NP_115583.1	Q9H6X5	CS044_HUMAN	chromosome 19 open reading frame 44	147										endometrium(1)|large_intestine(5)|lung(5)|ovary(1)|skin(1)|stomach(1)|urinary_tract(2)	16						GTCCCAGAACACAGACAAAAC	0.502000													20	72					0	0	1	0	0
DHTKD1	55526	broad.mit.edu	37	10	12159682	12159682	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr10:12159682C>T	ENST00000263035.4	+	14	2392	c.2330C>T	c.(2329-2331)tCa>tTa	p.S777L		NM_018706.5	NP_061176	Q96HY7	DHTK1_HUMAN	dehydrogenase E1 and transketolase domain containing 1	777					glycolysis	mitochondrion	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(1)	44		Renal(717;0.228)	BRCA - Breast invasive adenocarcinoma(52;0.188)			GCAGCCGTGTCAACTCTTCAA	0.448000													32	97					0	0	1	0	0
OGG1	4968	broad.mit.edu	37	3	9793520	9793520	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:9793520A>G	ENST00000302036.7	+	3	795	c.452A>G	c.(451-453)aAc>aGc	p.N151S	OGG1_ENST00000349503.5_Missense_Mutation_p.N151S|OGG1_ENST00000339511.5_Missense_Mutation_p.N151S|OGG1_ENST00000302003.7_Missense_Mutation_p.N151S|OGG1_ENST00000302008.8_Missense_Mutation_p.N151S|OGG1_ENST00000383826.5_Missense_Mutation_p.N151S|OGG1_ENST00000449570.2_Missense_Mutation_p.N151S|OGG1_ENST00000344629.7_Missense_Mutation_p.N151S	NM_016821.2	NP_058214.1	O15527	OGG1_HUMAN	8-oxoguanine DNA glycosylase	151					depurination|nucleotide-excision repair|regulation of protein import into nucleus, translocation|regulation of transcription, DNA-dependent|response to oxidative stress|response to radiation	mitochondrion|nuclear matrix|nuclear speck	damaged DNA binding|endonuclease activity|oxidized purine base lesion DNA N-glycosylase activity|protein binding			kidney(2)|large_intestine(2)|lung(2)|skin(1)|urinary_tract(1)	8	Medulloblastoma(99;0.227)					TCCAACAACAACATCGCCCGC	0.557000								Base excision repair (BER), DNA glycosylases					37	126					0	0	1	0	0
AATK	9625	broad.mit.edu	37	17	79092237	79092237	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr17:79092237C>T	ENST00000326724.4	-	14	4114	c.4090G>A	c.(4090-4092)Gaa>Aaa	p.E1364K	AATK_ENST00000417379.1_Missense_Mutation_p.E1261K	NM_001080395.2	NP_001073864.2	Q6ZMQ8	LMTK1_HUMAN	apoptosis-associated tyrosine kinase	1364						integral to membrane|mitochondrion|perinuclear region of cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			endometrium(2)|kidney(2)|lung(8)|ovary(3)|prostate(1)|stomach(4)|upper_aerodigestive_tract(1)	21	all_neural(118;0.101)		BRCA - Breast invasive adenocarcinoma(99;0.0228)|OV - Ovarian serous cystadenocarcinoma(97;0.0524)			GCACCAGCTTCAGGTCCTGGC	0.642000													3	11					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9049770	9049770	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:9049770C>A	ENST00000397910.4	-	5	32064	c.31861G>T	c.(31861-31863)Gaa>Taa	p.E10621*		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	10623	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTGTCTAATTCACTGTGGAAA	0.473000													13	79					1.3612e-06	1.42e-06	1	1	0
KIAA0100	9703	broad.mit.edu	37	17	26951373	26951373	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr17:26951373C>T	ENST00000528896.2	-	25	4704	c.4630G>A	c.(4630-4632)Gat>Aat	p.D1544N	KIAA0100_ENST00000544884.1_Missense_Mutation_p.D1401N|KIAA0100_ENST00000389003.3_Missense_Mutation_p.D1401N	NM_014680.3	NP_055495.2	Q14667	K0100_HUMAN	KIAA0100	1544						extracellular region				breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(23)|ovary(2)|prostate(2)|skin(6)|stomach(2)|urinary_tract(3)	68	Lung NSC(42;0.00431)					ACAAACCTATCTGTCTCTTCA	0.468000													24	62					0	0	1	0	0
MVB12A	93343	broad.mit.edu	37	19	17535761	17535761	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:17535761G>C	ENST00000317040.7	+	9	1836	c.781G>C	c.(781-783)Gag>Cag	p.E261Q	MVB12A_ENST00000529939.1_Intron|MVB12A_ENST00000543795.1_Missense_Mutation_p.E261Q|MVB12A_ENST00000392702.2_Missense_Mutation_p.E221Q					multivesicular body subunit 12A																		CTTCGTGGTGGAGAAGACCGC	0.632000											OREG0025346	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	38	162					0	0	1	0	0
BRD9	65980	broad.mit.edu	37	5	887506	887506	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr5:887506G>A	ENST00000323510.4	-	3	338	c.339C>T	c.(337-339)atC>atT	p.I113I	BRD9_ENST00000435709.2_Silent_p.I113I|BRD9_ENST00000388890.4_Silent_p.I113I|BRD9_ENST00000467963.1_Silent_p.I229I|BRD9_ENST00000483173.1_Silent_p.I176I			Q9H8M2	BRD9_HUMAN	bromodomain containing 9	229							nucleic acid binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|pancreas(1)|prostate(3)	29			Epithelial(17;0.00202)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00815)|Lung(60;0.185)			CTGCGTGAAGGATCTTCTTCG	0.488000													66	713					0	0	1	0	0
KIAA0922	23240	broad.mit.edu	37	4	154517526	154517526	+	Silent	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr4:154517526C>G	ENST00000409663.3	+	20	2161	c.2109C>G	c.(2107-2109)ctC>ctG	p.L703L	KIAA0922_ENST00000440693.1_Silent_p.L620L|KIAA0922_ENST00000409959.3_Silent_p.L704L	NM_015196.3	NP_056011.3	A2VDJ0	T131L_HUMAN	KIAA0922	703						integral to membrane				breast(2)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(16)|lung(20)|ovary(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	63	all_hematologic(180;0.093)	Renal(120;0.118)				TTACCTCACTCATACTAATCC	0.418000													25	57					0	0	1	0	0
TMEM79	84283	broad.mit.edu	37	1	156255264	156255264	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:156255264C>T	ENST00000405535.2	+	2	418	c.247C>T	c.(247-249)Cag>Tag	p.Q83*	TMEM79_ENST00000357501.2_Intron|TMEM79_ENST00000295694.5_Nonsense_Mutation_p.Q83*|TMEM79_ENST00000495881.1_3'UTR	NM_032323.2	NP_115699.1	Q9BSE2	TMM79_HUMAN	transmembrane protein 79	83						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(9)|urinary_tract(1)	21	Hepatocellular(266;0.158)					GACTGGCCCTCAGCCCAGTGC	0.622000													17	54					0	0	1	0	0
UTRN	7402	broad.mit.edu	37	6	144803404	144803404	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr6:144803404C>T	ENST00000367545.3	+	26	3567	c.3567C>T	c.(3565-3567)atC>atT	p.I1189I		NM_007124.2	NP_009055.2	P46939	UTRO_HUMAN	utrophin	1189					muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|cervix(2)|endometrium(21)|kidney(10)|large_intestine(29)|lung(56)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	148		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		AGGACAACATCAAGTTATTAG	0.458000													17	44					0	0	1	0	0
SLC26A10	65012	broad.mit.edu	37	12	58015503	58015503	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr12:58015503C>T	ENST00000379218.2	+	4	897	c.586C>T	c.(586-588)Cgg>Tgg	p.R196W	SLC26A10_ENST00000320442.4_Missense_Mutation_p.R196W			Q8NG04	S2610_HUMAN	solute carrier family 26, member 10	196						integral to membrane	antiporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(5)|large_intestine(4)|lung(7)	19	Melanoma(17;0.122)					TGCGCTGCCTCGGAGCAGTCC	0.697000											OREG0021948	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	13					0	0	1	0	0
CYP2C18	1562	broad.mit.edu	37	10	96466665	96466665	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr10:96466665A>T	ENST00000285979.6	+	5	966	c.767A>T	c.(766-768)gAc>gTc	p.D256V	CYP2C18_ENST00000339022.5_Intron|CYP2C19_ENST00000464755.1_3'UTR	NM_000772.2	NP_000763.1			cytochrome P450, family 2, subfamily C, polypeptide 18											NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(11)|ovary(3)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	26		Colorectal(252;0.09)		all cancers(201;2.8e-06)|KIRC - Kidney renal clear cell carcinoma(50;0.0646)|Kidney(138;0.0805)		GAATCCCTGGACATGAACAGT	0.338000													8	19					0	0	1	0	0
SLITRK1	114798	broad.mit.edu	37	13	84453714	84453714	+	Silent	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr13:84453714C>G	ENST00000377084.2	-	1	2814	c.1929G>C	c.(1927-1929)ctG>ctC	p.L643L		NM_001281503.1|NM_052910.1	NP_001268432.1|NP_443142.1	Q96PX8	SLIK1_HUMAN	SLIT and NTRK-like family, member 1	643						integral to membrane				NS(2)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(36)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	80	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		TTCGGTTCCTCAGGATAAACA	0.567000													12	22					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114276537	114276537	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr4:114276537G>C	ENST00000357077.4	+	38	6816	c.6763G>C	c.(6763-6765)Gag>Cag	p.E2255Q	ANK2_ENST00000506722.1_Intron|ANK2_ENST00000264366.6_Missense_Mutation_p.E2222Q|ANK2_ENST00000510275.2_Intron|ANK2_ENST00000509550.1_Intron|ANK2_ENST00000394537.3_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	2222					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		AAAGAAAAGTGAGGAGCAAAC	0.468000													15	33					0	0	1	0	0
NLRC5	84166	broad.mit.edu	37	16	57060627	57060627	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr16:57060627A>T	ENST00000436936.1	+	6	1997	c.1772A>T	c.(1771-1773)aAg>aTg	p.K591M	NLRC5_ENST00000262510.6_Missense_Mutation_p.K591M|NLRC5_ENST00000308149.7_Missense_Mutation_p.K591M|NLRC5_ENST00000539144.1_Missense_Mutation_p.K591M			Q86WI3	NLRC5_HUMAN	NLR family, CARD domain containing 5	591					defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			NS(2)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(21)|ovary(8)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	75		all_neural(199;0.225)				GTGGGTGCCAAGCAGGCTGCT	0.612000													29	19					0	0	1	0	0
ACAA1	30	broad.mit.edu	37	3	38167707	38167707	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:38167707C>A	ENST00000333167.8	-	9	1115	c.943G>T	c.(943-945)Gac>Tac	p.D315Y	ACAA1_ENST00000301810.7_Intron|ACAA1_ENST00000544624.1_3'UTR|ACAA1_ENST00000480865.1_5'UTR|ACAA1_ENST00000450296.1_Missense_Mutation_p.D274Y	NM_001607.3	NP_001598.1	P09110	THIK_HUMAN	acetyl-CoA acyltransferase 1	315					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy	peroxisomal matrix	acetyl-CoA C-acyltransferase activity|protein binding			endometrium(1)|large_intestine(4)|lung(2)|ovary(1)|prostate(1)	9				KIRC - Kidney renal clear cell carcinoma(284;0.0523)|Kidney(284;0.0657)		CCCATGATGTCAGGTGGGACC	0.572000													6	81					2.7689e-08	2.90418e-08	1	1	0
GRIA2	2891	broad.mit.edu	37	4	158257000	158257000	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr4:158257000A>G	ENST00000296526.7	+	10	1769	c.1444A>G	c.(1444-1446)Aat>Gat	p.N482D	GRIA2_ENST00000449365.1_Missense_Mutation_p.N435D|GRIA2_ENST00000507898.1_Missense_Mutation_p.N435D|GRIA2_ENST00000393815.2_Missense_Mutation_p.N435D|GRIA2_ENST00000264426.9_Missense_Mutation_p.N482D	NM_000826.3	NP_000817	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2	482					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(2)|lung(32)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	79	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	GAAAATTTGGAATGGGATGGT	0.433000													14	17					0	0	1	0	0
AZU1	566	broad.mit.edu	37	19	829604	829604	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:829604G>A	ENST00000233997.2	+	3	279	c.258G>A	c.(256-258)ctG>ctA	p.L86L		NM_001700.3	NP_001691.1	P20160	CAP7_HUMAN	azurocidin 1	86	Peptidase S1.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis|cellular extravasation|defense response to Gram-negative bacterium|glial cell migration|induction of positive chemotaxis|inflammatory response|macrophage chemotaxis|microglial cell activation|monocyte activation|positive regulation of cell adhesion|positive regulation of fractalkine biosynthetic process|positive regulation of interleukin-1 beta biosynthetic process|positive regulation of MHC class II biosynthetic process|positive regulation of phagocytosis|positive regulation of tumor necrosis factor biosynthetic process|proteolysis|regulation of vascular permeability	azurophil granule|extracellular region	heparin binding|serine-type endopeptidase activity|toxin binding			NS(1)|endometrium(1)|kidney(1)|lung(4)|pancreas(1)|upper_aerodigestive_tract(2)	10		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;0.000172)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTATGACCTGAGGCGGCGGG	0.632000													28	85					0	0	1	0	0
CALR	811	broad.mit.edu	37	19	13050907	13050907	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:13050907C>T	ENST00000316448.5	+	4	511	c.438C>T	c.(436-438)gtC>gtT	p.V146V		NM_004343.3	NP_004334.1	P27797	CALR_HUMAN	calreticulin	146	N-domain.				cell cycle arrest|cellular senescence|glucocorticoid receptor signaling pathway|negative regulation of neuron differentiation|negative regulation of retinoic acid receptor signaling pathway|negative regulation of steroid hormone receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative regulation of translation|peptide antigen assembly with MHC class I protein complex|positive regulation of cell cycle|positive regulation of cell proliferation|positive regulation of DNA replication|positive regulation of phagocytosis|post-translational protein modification|protein export from nucleus|protein maturation by protein folding|protein N-linked glycosylation via asparagine|protein stabilization|regulation of apoptosis|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|extracellular space|MHC class I peptide loading complex|nucleus|perinuclear region of cytoplasm|polysome|proteinaceous extracellular matrix	androgen receptor binding|calcium ion binding|chaperone binding|complement component C1q binding|DNA binding|integrin binding|mRNA binding|protein binding involved in protein folding|sugar binding|ubiquitin protein ligase binding|unfolded protein binding|zinc ion binding			kidney(1)|large_intestine(3)|lung(5)|ovary(1)	10					Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGGTTCATGTCATCTTCAACT	0.527000													21	44					0	0	1	0	0
DNAH1	25981	broad.mit.edu	37	3	52429619	52429619	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:52429619C>T	ENST00000420323.2	+	70	11445	c.11184C>T	c.(11182-11184)ttC>ttT	p.F3728F		NM_015512.4	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	3793	AAA 6 (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		AATGGGTCTTCTTCCAGAACT	0.622000													7	39					0	0	1	0	0
KCNN1	3780	broad.mit.edu	37	19	18092644	18092644	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:18092644T>C	ENST00000222249.9	+	5	944	c.625T>C	c.(625-627)Tgg>Cgg	p.W209R		NM_002248.3	NP_002239.2	Q92952	KCNN1_HUMAN	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1						synaptic transmission	voltage-gated potassium channel complex	calmodulin binding|small conductance calcium-activated potassium channel activity			endometrium(1)|kidney(1)|lung(5)|urinary_tract(1)	8						CCGCTTCACGTGGACGGCGCG	0.677000													10	26					0	0	1	0	0
KCNC1	3746	broad.mit.edu	37	11	17757811	17757811	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr11:17757811G>A	ENST00000379472.3	+	1	292	c.262G>A	c.(262-264)Gag>Aag	p.E88K	KCNC1_ENST00000265969.6_Missense_Mutation_p.E88K	NM_004976.4	NP_004967.1	P48547	KCNC1_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 1	88						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(9)|lung(7)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	33						GCCGCTCTACGAGGAGGAGCT	0.672000													11	29					0	0	1	0	0
CDH20	28316	broad.mit.edu	37	18	59166463	59166463	+	Silent	SNP	C	C	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr18:59166463C>A	ENST00000262717.4	+	3	689	c.291C>A	c.(289-291)atC>atA	p.I97I	CDH20_ENST00000536675.2_Silent_p.I97I|CDH20_ENST00000538374.1_Silent_p.I97I			Q9HBT6	CAD20_HUMAN	cadherin 20, type 2	97	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(33)|ovary(1)|pancreas(1)|skin(3)	61		Colorectal(73;0.186)				TCAAATACATCCTCTCGGGAG	0.498000													6	22					2.0095e-06	2.09178e-06	1	1	0
OR10J3	441911	broad.mit.edu	37	1	159284182	159284182	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:159284182G>A	ENST00000332217.5	-	1	267	c.268C>T	c.(268-270)Cat>Tat	p.H90Y		NM_001004467.1	NP_001004467.1	Q5JRS4	O10J3_HUMAN	olfactory receptor, family 10, subfamily J, member 3	90					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(7)|kidney(4)|large_intestine(7)|lung(19)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	47	all_hematologic(112;0.0429)					ATGGGCTGATGAGGATTCAAG	0.502000													15	369					0	0	1	0	0
PAPD4	167153	broad.mit.edu	37	5	78936676	78936676	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr5:78936676G>A	ENST00000453514.1	+	5	1161	c.468G>A	c.(466-468)ttG>ttA	p.L156L	PAPD4_ENST00000296783.3_Silent_p.L156L|PAPD4_ENST00000428308.2_Silent_p.L156L|PAPD4_ENST00000423041.2_Silent_p.L156L|PAPD4_ENST00000504233.1_Silent_p.L156L	NM_001114394.1	NP_001107866.1	Q6PIY7	GLD2_HUMAN	PAP associated domain containing 4	156					histone mRNA catabolic process|mRNA processing|RNA polyadenylation	cytoplasm	ATP binding|metal ion binding|polynucleotide adenylyltransferase activity			biliary_tract(1)|breast(2)|endometrium(4)|kidney(3)|large_intestine(9)|lung(4)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	29		Lung NSC(167;0.00293)|all_lung(232;0.00323)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;8.61e-47)|Epithelial(54;1.32e-41)|all cancers(79;2.45e-36)		GATTCAAGTTGAGTCAGCAGA	0.338000													7	14					0	0	1	0	0
ZNF148	7707	broad.mit.edu	37	3	124951219	124951219	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:124951219G>A	ENST00000360647.4	-	9	2836	c.2351C>T	c.(2350-2352)tCa>tTa	p.S784L	ZNF148_ENST00000468369.1_Missense_Mutation_p.S134L|ZNF148_ENST00000484491.1_Missense_Mutation_p.S784L|ZNF148_ENST00000544464.1_Missense_Mutation_p.S121L|ZNF148_ENST00000492394.1_Missense_Mutation_p.S784L|ZNF148_ENST00000485866.1_Missense_Mutation_p.S784L|SLC12A8_ENST00000423114.2_Intron|ZNF148_ENST00000497929.1_5'UTR	NM_021964.2	NP_068799.2	Q9UQR1	ZN148_HUMAN	zinc finger protein 148	784					cellular defense response|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			breast(3)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(3)|liver(1)|lung(6)|ovary(1)|pancreas(1)|prostate(2)|skin(3)	28						GGCATCAGGTGAAGATGTCAT	0.408000													18	61					0	0	1	0	0
SOX8	30812	broad.mit.edu	37	16	1033751	1033751	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr16:1033751G>A	ENST00000293894.3	+	2	561	c.446G>A	c.(445-447)cGg>cAg	p.R149Q		NM_014587.3	NP_055402.2	P57073	SOX8_HUMAN	SRY (sex determining region Y)-box 8	149					adipose tissue development|enteric nervous system development|fat cell differentiation|in utero embryonic development|metanephric nephron tubule formation|morphogenesis of a branching epithelium|negative regulation of apoptosis|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-dependent|neural crest cell migration|oligodendrocyte differentiation|osteoblast differentiation|peripheral nervous system development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of gliogenesis|positive regulation of osteoblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of hormone levels|renal vesicle induction|retinal rod cell differentiation|Sertoli cell development|signal transduction|spermatogenesis|ureter morphogenesis	cytoplasm|nucleus				central_nervous_system(1)|kidney(1)|lung(5)|prostate(2)|skin(1)	10		Hepatocellular(780;0.00308)				AGCGAGAAGCGGCCCTTCGTG	0.677000													17	33					0	0	1	0	0
SUPT6H	6830	broad.mit.edu	37	17	27001432	27001432	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr17:27001432G>A	ENST00000314616.6	+	3	524	c.241G>A	c.(241-243)Gat>Aat	p.D81N	SUPT6H_ENST00000347486.4_Missense_Mutation_p.D81N	NM_003170.3	NP_003161.2	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog (S. cerevisiae)	81	Asp/Glu-rich.				chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			NS(4)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(15)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64	Lung NSC(42;0.00431)					TTCAGAAGATGATGTTGGCCA	0.493000													7	30					0	0	1	0	0
H1FX	8971	broad.mit.edu	37	3	129034689	129034689	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:129034689C>T	ENST00000333762.4	-	1	431	c.57G>A	c.(55-57)aaG>aaA	p.K19K	H1FX-AS1_ENST00000433902.2_RNA|H1FX-AS1_ENST00000511998.1_RNA	NM_006026.3	NP_006017.1	Q92522	H1X_HUMAN	H1 histone family, member X	19					nucleosome assembly	nucleosome|nucleus	DNA binding			kidney(1)|ovary(1)|urinary_tract(2)	4						TGGTCACCTTCTTGGCCATTC	0.642000													3	13					0	0	1	0	0
FNDC1	84624	broad.mit.edu	37	6	159650896	159650896	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr6:159650896C>T	ENST00000297267.9	+	10	1430	c.1230C>T	c.(1228-1230)tcC>tcT	p.S410S	FNDC1_ENST00000340366.6_Intron	NM_032532.2	NP_115921.2	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	410	Fibronectin type-III 4.					extracellular region				NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(29)|liver(2)|lung(23)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)	93		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		GAGCAAAGTCCCTCACCTATC	0.502000													57	207					0	0	1	0	0
MFN1	55669	broad.mit.edu	37	3	179096596	179096596	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:179096596C>T	ENST00000471841.1	+	14	1782	c.1656C>T	c.(1654-1656)atC>atT	p.I552I	MFN1_ENST00000280653.7_Intron|MFN1_ENST00000263969.5_Silent_p.I552I	NM_033540.2	NP_284941	Q8IWA4	MFN1_HUMAN	mitofusin 1	552					mitochondrial fusion	integral to membrane|mitochondrial outer membrane	GTP binding|GTPase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(14)|ovary(3)|prostate(1)|urinary_tract(1)	31	all_cancers(143;1.67e-16)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.00225)|BRCA - Breast invasive adenocarcinoma(182;0.0923)			CAGAGCCTATCTTTCAGGTAT	0.358000													11	43					0	0	1	0	0
ZNF354A	6940	broad.mit.edu	37	5	178139118	178139118	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr5:178139118G>A	ENST00000335815.2	-	5	1958	c.1761C>T	c.(1759-1761)ttC>ttT	p.F587F		NM_005649.2	NP_005640.2	O60765	Z354A_HUMAN	zinc finger protein 354A	587					regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|large_intestine(7)|lung(3)|ovary(2)|skin(2)|stomach(2)	19	all_cancers(89;0.000536)|Renal(175;0.000159)|all_epithelial(37;0.000221)|Lung NSC(126;0.00308)|all_lung(126;0.00536)	all_cancers(40;0.0452)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.185)		ACCTATGGTTGAAAAGTTTCC	0.363000													7	31					0	0	1	0	0
IL17RB	55540	broad.mit.edu	37	3	53891011	53891011	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:53891011G>A	ENST00000288167.3	+	7	679	c.670G>A	c.(670-672)Gag>Aag	p.E224K		NM_018725.3	NP_061195.2	Q9NRM6	I17RB_HUMAN	interleukin 17 receptor B	224					defense response|regulation of cell growth	extracellular region|integral to plasma membrane	cytokine receptor activity			breast(1)|endometrium(1)|large_intestine(3)|lung(2)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)	13				BRCA - Breast invasive adenocarcinoma(193;0.000158)|KIRC - Kidney renal clear cell carcinoma(284;0.00588)|Kidney(284;0.00673)|OV - Ovarian serous cystadenocarcinoma(275;0.118)		TCAGGTGTTTGAGGTACTTTT	0.478000													20	115					0	0	1	0	0
RHEB	6009	broad.mit.edu	37	7	151181846	151181846	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr7:151181846G>A	ENST00000262187.5	-	3	581	c.169C>T	c.(169-171)Caa>Taa	p.Q57*	RHEB_ENST00000496004.1_5'UTR|RHEB_ENST00000472642.1_5'UTR	NM_005614.3	NP_005605.1	Q15382	RHEB_HUMAN	Ras homolog enriched in brain	57					cell cycle arrest|insulin receptor signaling pathway|positive regulation of TOR signaling cascade|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding|GTPase activity|metal ion binding|protein binding			breast(3)|endometrium(1)|kidney(2)|large_intestine(1)|lung(7)	14			OV - Ovarian serous cystadenocarcinoma(82;0.00306)	UCEC - Uterine corpus endometrioid carcinoma (81;0.174)		TCTACAAGTTGAAGATGATAT	0.353000													15	23					0	0	1	0	0
ACMSD	130013	broad.mit.edu	37	2	135602802	135602802	+	Splice_Site	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:135602802G>A	ENST00000356140.5	+	2	193		c.e2-1		AC016725.4_ENST00000392929.2_RNA|ACMSD_ENST00000392928.1_Splice_Site|ACMSD_ENST00000283054.4_Splice_Site	NM_138326.2	NP_612199.2	Q8TDX5	ACMSD_HUMAN	aminocarboxymuconate semialdehyde decarboxylase						quinolinate metabolic process|tryptophan catabolic process	cytosol	aminocarboxymuconate-semialdehyde decarboxylase activity|metal ion binding			endometrium(3)|large_intestine(4)|lung(6)|skin(1)	14				BRCA - Breast invasive adenocarcinoma(221;0.115)		CCCCACTGCAGAGGTTTGGCT	0.522000													21	49					0	0	1	0	0
KIAA1109	84162	broad.mit.edu	37	4	123255642	123255642	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr4:123255642C>T	ENST00000264501.4	+	69	12163	c.11790C>T	c.(11788-11790)tcC>tcT	p.S3930S	KIAA1109_ENST00000388738.3_Silent_p.S3930S			Q2LD37	K1109_HUMAN	KIAA1109	3930					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						CTTTACCTTCCACTGTCCAGA	0.438000													14	31					0	0	1	0	0
MMP16	4325	broad.mit.edu	37	8	89053943	89053943	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr8:89053943A>G	ENST00000286614.6	-	10	1851	c.1570T>C	c.(1570-1572)Tcc>Ccc	p.S524P		NM_005941.4	NP_005932.2	P51512	MMP16_HUMAN	matrix metallopeptidase 16 (membrane-inserted)	524	Hemopexin-like 4.				collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(5)|liver(1)|lung(51)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	81						TTGAGGATGGATCTTGGATAT	0.418000													18	23					0	0	1	0	0
ZNF37A	7587	broad.mit.edu	37	10	38407469	38407469	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr10:38407469G>A	ENST00000361085.5	+	7	1735	c.1390G>A	c.(1390-1392)Gag>Aag	p.E464K	ZNF37A_ENST00000351773.3_Missense_Mutation_p.E464K	NM_001178101.1|NM_003421.2	NP_001171572.1|NP_003412.1	P17032	ZN37A_HUMAN	zinc finger protein 37A							nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(13)|prostate(1)	28						ACACACAGGGGAGAAACCTTT	0.413000													11	25					0	0	1	0	0
PSMD11	5717	broad.mit.edu	37	17	30796165	30796165	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr17:30796165C>T	ENST00000261712.3	+	6	860	c.597C>T	c.(595-597)gcC>gcT	p.A199A	PSMD11_ENST00000457654.2_Silent_p.A199A	NM_001270482.1|NM_002815.3	NP_001257411.1|NP_002806.2	O00231	PSD11_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11	199					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	19		Breast(31;0.159)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.109)			CAGCAAATGCCATCTACTGCC	0.478000													11	47					0	0	1	0	0
CDH10	1008	broad.mit.edu	37	5	24509744	24509744	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr5:24509744T>C	ENST00000264463.4	-	7	1694	c.1187A>G	c.(1186-1188)gAt>gGt	p.D396G		NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	396	Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		CACTTCAATATCTTCATGAAC	0.393000										HNSCC(23;0.051)			17	60					0	0	1	0	0
ITLN1	55600	broad.mit.edu	37	1	160851891	160851891	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:160851891C>T	ENST00000326245.3	-	4	376	c.261G>A	c.(259-261)gaG>gaA	p.E87E		NM_017625.2	NP_060095.2	Q8WWA0	ITLN1_HUMAN	intelectin 1 (galactofuranose binding)	87	Fibrinogen C-terminal.				positive regulation of glucose import|positive regulation of protein phosphorylation|response to nematode|signal transduction	anchored to membrane|brush border membrane|extracellular region|membrane raft	receptor binding|sugar binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(6)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	21	all_cancers(52;2.99e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			GCATGTCATTCTCGTGCACGC	0.597000													22	450					0	0	1	0	0
THEMIS	387357	broad.mit.edu	37	6	128134134	128134134	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr6:128134134G>A	ENST00000368250.1	-	5	1913	c.1415C>T	c.(1414-1416)tCa>tTa	p.S472L	THEMIS_ENST00000543064.1_Missense_Mutation_p.S551L|THEMIS_ENST00000537166.1_Missense_Mutation_p.S516L|THEMIS_ENST00000368248.2_Missense_Mutation_p.S551L			Q8N1K5	THMS1_HUMAN	thymocyte selection associated	551	CABIT 2.				negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(3)	60						TGGGGGATGTGAGGCTGAGCT	0.478000													22	97					0	0	1	0	0
ZNF836	162962	broad.mit.edu	37	19	52660686	52660686	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:52660686C>G	ENST00000322146.8	-	5	771	c.250G>C	c.(250-252)Gaa>Caa	p.E84Q	CTC-471J1.8_ENST00000594362.1_RNA|ZNF836_ENST00000597252.1_Missense_Mutation_p.E84Q	NM_001102657.1	NP_001096127.1	Q6ZNA1	ZN836_HUMAN	zinc finger protein 836	84					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(9)|lung(10)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26						TAAAAATTTTCAACATCATAA	0.343000													12	28					0	0	1	0	0
ME1	4199	broad.mit.edu	37	6	83949352	83949352	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr6:83949352G>T	ENST00000369705.3	-	8	934	c.818C>A	c.(817-819)aCa>aAa	p.T273K	ME1_ENST00000541327.1_Missense_Mutation_p.T107K|ME1_ENST00000543031.1_Missense_Mutation_p.T198K	NM_002395.4	NP_002386.1	P48163	MAOX_HUMAN	malic enzyme 1, NADP(+)-dependent, cytosolic	273					carbohydrate metabolic process|cellular lipid metabolic process|malate metabolic process|NADP biosynthetic process|response to carbohydrate stimulus|response to hormone stimulus	cytosol	ADP binding|electron carrier activity|malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity|manganese ion binding|NAD binding|NADP binding			NS(2)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(7)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36		all_cancers(76;1.28e-06)|Acute lymphoblastic leukemia(125;5.03e-07)|all_hematologic(105;0.000238)|all_epithelial(107;0.00218)		BRCA - Breast invasive adenocarcinoma(397;0.0641)	NADH(DB00157)	AACAGATGCTGTTCCTGAAAC	0.368000													3	33					0.115264	0.115623	1	1	0
TP53BP2	7159	broad.mit.edu	37	1	223976731	223976731	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:223976731G>A	ENST00000391878.2	-	17	3523	c.2755C>T	c.(2755-2757)Cag>Tag	p.Q919*	TP53BP2_ENST00000498843.1_5'UTR|TP53BP2_ENST00000343537.7_Nonsense_Mutation_p.Q1048*|TP53BP2_ENST00000391879.2_Nonsense_Mutation_p.Q281*	NM_005426.2	NP_005417.1	Q13625	ASPP2_HUMAN	tumor protein p53 binding protein, 2	1042	Mediates interaction with APC2.				apoptosis|cell cycle|induction of apoptosis|negative regulation of cell cycle|signal transduction	nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protein binding|SH3 domain binding|SH3/SH2 adaptor activity			NS(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|prostate(1)|skin(2)	29				GBM - Glioblastoma multiforme(131;0.0958)		TGGGAGCACTGAGTGTAGCCT	0.408000													45	60					0	0	1	0	0
DGKK	139189	broad.mit.edu	37	X	50213562	50213562	+	RNA	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chrX:50213562G>A	ENST00000376025.2	-	0	175							Q5KSL6	DGKK_HUMAN	diacylglycerol kinase, kappa						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			central_nervous_system(1)|endometrium(12)|kidney(4)|large_intestine(5)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Ovarian(276;0.236)					agccggcggcggagccggtgg	0.716000													9	19					0	0	1	0	0
PLEKHG4	25894	broad.mit.edu	37	16	67322086	67322086	+	Silent	SNP	G	G	A	rs147886474	byFrequency	TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr16:67322086G>A	ENST00000360461.5	+	19	5772	c.3237G>A	c.(3235-3237)gcG>gcA	p.A1079A	PLEKHG4_ENST00000427155.2_Silent_p.A1079A|PLEKHG4_ENST00000379344.3_Silent_p.A1079A|PLEKHG4_ENST00000450733.1_Silent_p.A998A	NM_001129727.1|NM_015432.3	NP_001123199.1|NP_056247.1	Q58EX7	PKHG4_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 4	1079					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37				OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)|Kidney(780;0.119)		GCTCTCGGGCGTCCATTGCCG	0.607000													54	32					0	0	1	0	0
RTP2	344892	broad.mit.edu	37	3	187416376	187416376	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:187416376G>A	ENST00000358241.1	-	2	1016	c.588C>T	c.(586-588)ttC>ttT	p.F196F		NM_001004312.2	NP_001004312.2	Q5QGT7	RTP2_HUMAN	receptor (chemosensory) transporter protein 2	196					protein insertion into membrane	cell surface|integral to membrane|plasma membrane	olfactory receptor binding			large_intestine(3)|lung(14)|skin(1)	18	all_cancers(143;4.06e-12)|Ovarian(172;0.0418)		OV - Ovarian serous cystadenocarcinoma(80;1.76e-18)	GBM - Glioblastoma multiforme(93;0.0515)		GAAGAGACAAGAAGTTGTAGC	0.582000													10	54					0	0	1	0	0
KMT2B	9757	broad.mit.edu	37	19	36220083	36220083	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:36220083C>T	ENST00000420124.1	+	22	4803	c.4803C>T	c.(4801-4803)atC>atT	p.I1601I	KMT2B_ENST00000607650.1_RNA|KMT2B_ENST00000222270.7_Silent_p.I1601I					lysine (K)-specific methyltransferase 2B																		TCTTGTACATCGGGCAGAACG	0.627000													6	17					0	0	1	0	0
GNAQ	2776	broad.mit.edu	37	9	80409445	80409445	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr9:80409445G>A	ENST00000286548.4	-	5	891	c.669C>T	c.(667-669)gtC>gtT	p.V223V	GNAQ_ENST00000397476.3_Silent_p.V21V	NM_002072.3	NP_002063.2	P50148	GNAQ_HUMAN	guanine nucleotide binding protein (G protein), q polypeptide	223					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|glutamate signaling pathway|negative regulation of protein kinase activity|platelet activation|protein ADP-ribosylation|protein stabilization|regulation of action potential|regulation of catenin import into nucleus	cytoplasm|heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activator activity|GTPase activity|signal transducer activity			NS(1)|endometrium(3)|eye(229)|kidney(1)|large_intestine(4)|lung(6)|meninges(11)|ovary(1)|prostate(1)|skin(44)|upper_aerodigestive_tract(1)	302						TGATAGAGGTGACATTTTCAA	0.378000			Mis		uveal melanoma								11	39					0	0	1	0	0
USP31	57478	broad.mit.edu	37	16	23085191	23085191	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr16:23085191C>T	ENST00000219689.7	-	14	2186	c.2187G>A	c.(2185-2187)aaG>aaA	p.K729K		NM_020718.3	NP_065769.3	Q70CQ4	UBP31_HUMAN	ubiquitin specific peptidase 31	729					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(17)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	57				GBM - Glioblastoma multiforme(48;0.0187)		CCACAGAGTTCTTACAGTACG	0.552000													24	44					0	0	1	0	0
PYGO2	90780	broad.mit.edu	37	1	154931355	154931355	+	Missense_Mutation	SNP	G	G	A	rs141762356		TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:154931355G>A	ENST00000368457.2	-	3	1292	c.1121C>T	c.(1120-1122)tCt>tTt	p.S374F	PYGO2_ENST00000368456.1_Missense_Mutation_p.S337F	NM_138300.3	NP_612157.1	Q9BRQ0	PYGO2_HUMAN	pygopus family PHD finger 2	374					Wnt receptor signaling pathway	nucleus	protein binding|zinc ion binding			endometrium(2)|large_intestine(2)|lung(3)|skin(2)|urinary_tract(1)	10	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			CCAGACGGCAGAAGCTTCAGT	0.587000													14	44					0	0	1	0	0
SLC39A6	25800	broad.mit.edu	37	18	33691099	33691099	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr18:33691099G>A	ENST00000269187.5	-	9	2251	c.2038C>T	c.(2038-2040)Cat>Tat	p.H680Y	SLC39A6_ENST00000590986.1_Missense_Mutation_p.H680Y|SLC39A6_ENST00000440549.2_Missense_Mutation_p.H405Y	NM_012319.3	NP_036451	Q13433	S39A6_HUMAN	solute carrier family 39 (zinc transporter), member 6	680						integral to membrane|lamellipodium membrane	zinc ion transmembrane transporter activity			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(4)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	41						TCAGCATAATGACCAATGAAA	0.388000													13	26					0	0	1	0	0
COL12A1	1303	broad.mit.edu	37	6	75836144	75836144	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr6:75836144C>T	ENST00000322507.8	-	39	6692	c.6383G>A	c.(6382-6384)tGg>tAg	p.W2128*	COL12A1_ENST00000483888.2_Nonsense_Mutation_p.W2128*|COL12A1_ENST00000345356.6_Nonsense_Mutation_p.W964*|COL12A1_ENST00000416123.2_Nonsense_Mutation_p.W2128*	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	2128	Fibronectin type-III 17.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						TCTTGTATACCATTCGTCAGA	0.433000													20	39					0	0	1	0	0
PRDM5	11107	broad.mit.edu	37	4	121739614	121739614	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr4:121739614G>C	ENST00000264808.3	-	5	784	c.544C>G	c.(544-546)Ctt>Gtt	p.L182V	PRDM5_ENST00000428209.2_Missense_Mutation_p.L182V|PRDM5_ENST00000515109.1_Missense_Mutation_p.L182V	NM_018699.2	NP_061169.2	Q9NQX1	PRDM5_HUMAN	PR domain containing 5	182					histone deacetylation|histone H3-K9 methylation|mitotic cell cycle|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	repressing transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(17)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						TGCTCAGCAAGAATATCCTCA	0.433000													9	31					0	0	1	0	0
NLRP8	126205	broad.mit.edu	37	19	56466417	56466417	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:56466417G>A	ENST00000291971.3	+	3	1064	c.993G>A	c.(991-993)ctG>ctA	p.L331L	NLRP8_ENST00000590542.1_Silent_p.L331L	NM_176811.2	NP_789781.2	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	331	NACHT.					cytoplasm	ATP binding			breast(4)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|ovary(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	35		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		CCACGCTACTGATCATGATAA	0.488000													46	77					0	0	1	0	0
PAK2	5062	broad.mit.edu	37	3	196509530	196509530	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:196509530G>T	ENST00000327134.3	+	2	335	c.13G>T	c.(13-15)Gga>Tga	p.G5*		NM_002577.4	NP_002568.2	Q13177	PAK2_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 2	5					axon guidance|cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of protein kinase activity|peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of apoptosis|regulation of defense response to virus by virus|regulation of growth|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|nucleus|perinuclear region of cytoplasm|plasma membrane	ATP binding|identical protein binding|protein kinase binding|protein serine/threonine kinase activity|protein tyrosine kinase activator activity			breast(1)|cervix(1)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)	12	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.07e-23)|all cancers(36;6.38e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.5e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00405)		GTCTGATAACGGAGAACTGGA	0.398000													33	185					1.62565e-12	1.72949e-12	1	1	0
FER	2241	broad.mit.edu	37	5	108281874	108281874	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr5:108281874C>T	ENST00000536402.1	+	8	1205	c.967C>T	c.(967-969)Caa>Taa	p.Q323*	FER_ENST00000281092.4_Missense_Mutation_p.S427L|FER_ENST00000438717.2_Missense_Mutation_p.S252L			P16591	FER_HUMAN	fer (fps/fes related) tyrosine kinase	0					intracellular signal transduction|peptidyl-tyrosine phosphorylation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			NS(2)|biliary_tract(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(12)|ovary(1)|skin(2)|stomach(1)|urinary_tract(2)	32		all_cancers(142;2.86e-06)|all_epithelial(76;9.81e-08)|Prostate(80;0.00972)|Lung NSC(167;0.039)|Ovarian(225;0.0448)|all_lung(232;0.0496)|Colorectal(57;0.0986)|Breast(839;0.152)		OV - Ovarian serous cystadenocarcinoma(64;6.77e-10)|Epithelial(69;4.13e-08)|COAD - Colon adenocarcinoma(37;0.0174)		ATTCGTCATTCAATTGCTGGA	0.393000													18	59					0	0	1	0	0
PI4KA	5297	broad.mit.edu	37	22	21159396	21159396	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr22:21159396G>A	ENST00000255882.6	-	11	1312	c.1226C>T	c.(1225-1227)aCg>aTg	p.T409M	PI4KA_ENST00000572273.1_Missense_Mutation_p.T351M	NM_058004.3	NP_477352.3	P42356	PI4KA_HUMAN	phosphatidylinositol 4-kinase, catalytic, alpha	351					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|synaptic transmission	Golgi-associated vesicle	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			breast(3)|endometrium(8)|kidney(9)|large_intestine(19)|lung(29)|ovary(1)|pancreas(1)|prostate(3)|salivary_gland(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	79	all_cancers(11;7.59e-25)|all_epithelial(7;1.34e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)			CCCCTGGCTCGTGTTGAACTG	0.532000													13	48					0	0	1	0	0
C10orf95	79946	broad.mit.edu	37	10	104211153	104211153	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr10:104211153C>G	ENST00000239125.1	-	1	147	c.73G>C	c.(73-75)Gaa>Caa	p.E25Q	RP11-18I14.10_ENST00000492465.2_RNA|RP11-18I14.10_ENST00000473970.2_RNA|RP11-18I14.10_ENST00000494270.2_RNA|RP11-18I14.10_ENST00000594818.1_RNA|RP11-18I14.10_ENST00000596045.1_RNA|RP11-18I14.10_ENST00000596366.1_RNA	NM_024886.1	NP_079162.1	Q9H7T3	CJ095_HUMAN	chromosome 10 open reading frame 95	25										liver(1)	1		Colorectal(252;0.207)		Epithelial(162;8.34e-09)|all cancers(201;1.95e-07)|BRCA - Breast invasive adenocarcinoma(275;0.213)		TTGTCTCCTTCAGCCTTGGGG	0.632000													8	27					0	0	1	0	0
PKDREJ	10343	broad.mit.edu	37	22	46656640	46656640	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr22:46656640G>A	ENST00000253255.5	-	1	2579	c.2580C>T	c.(2578-2580)aaC>aaT	p.N860N		NM_006071.1	NP_006062.1	Q9NTG1	PKDRE_HUMAN	polycystin (PKD) family receptor for egg jelly	860	REJ.				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			NS(2)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(4)|kidney(5)|large_intestine(21)|lung(16)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)	73		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		TGACATACATGTTGAAATTGG	0.378000													13	35					0	0	1	0	0
PCDHGA8	9708	broad.mit.edu	37	5	140772943	140772943	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr5:140772943G>C	ENST00000398604.2	+	1	563	c.563G>C	c.(562-564)gGa>gCa	p.G188A	PCDHGB3_ENST00000576222.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_032088.1	NP_114477.1														endometrium(6)|kidney(6)|large_intestine(6)|lung(30)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	51			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGAGACAATGGAGCCATAAAC	0.632000													31	49					0	0	1	0	0
MYO7B	4648	broad.mit.edu	37	2	128370125	128370125	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:128370125C>A	ENST00000389524.4	+	25	3320	c.3267C>A	c.(3265-3267)aaC>aaA	p.N1089K	MYO7B_ENST00000409816.2_Missense_Mutation_p.N1089K|MYO7B_ENST00000428314.1_Missense_Mutation_p.N1089K			Q6PIF6	MYO7B_HUMAN	myosin VIIB	1089	MyTH4 1.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(46)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	75	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		CCATGTCCAACCTGGAGAAGG	0.612000													3	2					0.150653	0.150966	1	1	0
GRTP1	79774	broad.mit.edu	37	13	113979932	113979932	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr13:113979932G>A	ENST00000375430.4	-	7	1011	c.965C>T	c.(964-966)cCg>cTg	p.P322L	GRTP1_ENST00000326039.3_Missense_Mutation_p.P244L|GRTP1_ENST00000375431.4_Intron			Q5TC63	GRTP1_HUMAN	growth hormone regulated TBC protein 1	0						intracellular	Rab GTPase activator activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)	14	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0314)|all_epithelial(44;0.011)|all_lung(25;0.0271)|Lung NSC(25;0.0978)|Breast(118;0.188)	all cancers(43;0.025)|GBM - Glioblastoma multiforme(44;0.206)|Epithelial(84;0.246)			CAGGTGAGGCGGGGCCCCCTG	0.627000													17	13					0	0	1	0	0
GON4L	54856	broad.mit.edu	37	1	155823384	155823384	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:155823384G>A	ENST00000437809.1	-	2	310	c.188C>T	c.(187-189)tCt>tTt	p.S63F	GON4L_ENST00000471341.1_5'UTR|GON4L_ENST00000271883.5_Missense_Mutation_p.S63F|GON4L_ENST00000368331.1_Missense_Mutation_p.S63F|GON4L_ENST00000361040.5_Missense_Mutation_p.S63F	NM_001282856.1	NP_001269785.1	Q3T8J9	GON4L_HUMAN	gon-4-like (C. elegans)	63					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(4)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	45	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					ATCCTGCAAAGACTGTACTTC	0.468000													56	158					0	0	1	0	0
CLPB	81570	broad.mit.edu	37	11	72018299	72018299	+	Splice_Site	SNP	C	C	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr11:72018299C>A	ENST00000294053.3	-	10	1330		c.e10-1		CLPB_ENST00000538039.1_Splice_Site|CLPB_ENST00000538021.1_Splice_Site|CLPB_ENST00000437826.2_Splice_Site|CLPB_ENST00000543042.1_Splice_Site|CLPB_ENST00000340729.5_Splice_Site	NM_001258394.1|NM_030813.4	NP_001245323.1|NP_110440.1	Q9H078	CLPB_HUMAN	ClpB caseinolytic peptidase B homolog (E. coli)						cellular response to heat		ATP binding|nucleoside-triphosphatase activity|protein binding			endometrium(3)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	19						TCTGTTTTTCCTAGTAAGAAA	0.438000													11	39					0.00010058	0.000103142	1	1	0
ATG12	9140	broad.mit.edu	37	5	115177286	115177286	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr5:115177286G>A	ENST00000274459.4	-	1	262	c.105C>T	c.(103-105)ctC>ctT	p.L35L	AP3S1_ENST00000316788.7_5'UTR|ATG12_ENST00000509910.1_5'UTR	NM_004707.3	NP_004698.3	O94817	ATG12_HUMAN	autophagy related 12	0					autophagic vacuole assembly|negative regulation of type I interferon production	pre-autophagosomal structure membrane	protein binding			endometrium(2)|kidney(1)|lung(1)|prostate(1)	5		all_cancers(142;0.00377)|all_epithelial(76;0.000129)|Prostate(80;0.0132)|Ovarian(225;0.0776)|Lung NSC(810;0.245)		OV - Ovarian serous cystadenocarcinoma(64;7.59e-08)|Epithelial(69;7.05e-07)|all cancers(49;3.11e-05)		AGTAGCGACTGAGCGCGTGCA	0.592000													37	102					0	0	1	0	0
MAVS	57506	broad.mit.edu	37	20	3835297	3835297	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr20:3835297A>G	ENST00000428216.2	+	2	154	c.26A>G	c.(25-27)tAt>tGt	p.Y9C	MAVS_ENST00000416600.2_5'UTR|MAVS_ENST00000358134.6_Missense_Mutation_p.Y9C	NM_020746.4	NP_065797.2	Q7Z434	MAVS_HUMAN	mitochondrial antiviral signaling protein	9					activation of innate immune response|cellular response to exogenous dsRNA|defense response to bacterium|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of chemokine (C-C motif) ligand 5 production|positive regulation of defense response to virus by host|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interleukin-8 production|positive regulation of IP-10 production|positive regulation of protein import into nucleus, translocation|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of type I interferon-mediated signaling pathway|response to virus	integral to membrane|mitochondrial outer membrane	CARD domain binding|protein kinase binding|signal transducer activity			autonomic_ganglia(1)|breast(3)|endometrium(1)|large_intestine(3)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	14						GACAAGACCTATAAGTATATC	0.498000													37	62					0	0	1	0	0
ZNF318	24149	broad.mit.edu	37	6	43307536	43307536	+	Silent	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr6:43307536G>C	ENST00000361428.2	-	10	4277	c.4200C>G	c.(4198-4200)ctC>ctG	p.L1400L	ZNF318_ENST00000318149.3_Intron	NM_014345.2	NP_055160.2	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	1400					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(21)|ovary(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	61			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			CTGGAGGTAAGAGGAGATCAG	0.468000													18	36					0	0	1	0	0
ME1	4199	broad.mit.edu	37	6	83949351	83949351	+	Silent	SNP	T	T	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr6:83949351T>C	ENST00000369705.3	-	8	935	c.819A>G	c.(817-819)acA>acG	p.T273T	ME1_ENST00000541327.1_Silent_p.T107T|ME1_ENST00000543031.1_Silent_p.T198T	NM_002395.4	NP_002386.1	P48163	MAOX_HUMAN	malic enzyme 1, NADP(+)-dependent, cytosolic	273					carbohydrate metabolic process|cellular lipid metabolic process|malate metabolic process|NADP biosynthetic process|response to carbohydrate stimulus|response to hormone stimulus	cytosol	ADP binding|electron carrier activity|malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity|manganese ion binding|NAD binding|NADP binding			NS(2)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(7)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36		all_cancers(76;1.28e-06)|Acute lymphoblastic leukemia(125;5.03e-07)|all_hematologic(105;0.000238)|all_epithelial(107;0.00218)		BRCA - Breast invasive adenocarcinoma(397;0.0641)	NADH(DB00157)	CAACAGATGCTGTTCCTGAAA	0.373000													3	33					0	0	1	0	0
RABEP2	79874	broad.mit.edu	37	16	28916292	28916292	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr16:28916292G>C	ENST00000358201.4	-	13	2270	c.1682C>G	c.(1681-1683)aCg>aGg	p.T561R	RABEP2_ENST00000544477.1_Missense_Mutation_p.T490R|RABEP2_ENST00000357573.6_Missense_Mutation_p.T525R	NM_024816.2	NP_079092.2	Q9H5N1	RABE2_HUMAN	rabaptin, RAB GTPase binding effector protein 2	561					endocytosis|protein transport	early endosome	growth factor activity|GTPase activator activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|skin(1)	16						CCTGACGTCCGTGAGTGGCGC	0.642000													8	82					0	0	1	0	0
PRDM16	63976	broad.mit.edu	37	1	3102852	3102852	+	Silent	SNP	G	G	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:3102852G>T	ENST00000378398.3	+	2	283	c.201G>T	c.(199-201)ccG>ccT	p.P67P	PRDM16_ENST00000378391.2_Silent_p.P67P|PRDM16_ENST00000442529.2_Silent_p.P67P|PRDM16_ENST00000511072.1_Silent_p.P67P|PRDM16_ENST00000514189.1_Silent_p.P67P|PRDM16_ENST00000441472.2_Silent_p.P67P|PRDM16_ENST00000270722.5_Silent_p.P67P			Q9HAZ2	PRD16_HUMAN	PR domain containing 16	67					brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(3)	59	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		AGGGCTCGCCGTACGAGGCCC	0.672000			T	EVI1	"""MDS, AML"""								18	44					1.56452e-12	1.6663e-12	1	1	0
NHLRC1	378884	broad.mit.edu	37	6	18122648	18122648	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr6:18122648G>A	ENST00000340650.3	-	1	203	c.190C>T	c.(190-192)Ctg>Ttg	p.L64L		NM_198586.2	NP_940988.2	Q6VVB1	NHLC1_HUMAN	NHL repeat containing 1	64					proteasomal ubiquitin-dependent protein catabolic process|protein polyubiquitination	endoplasmic reticulum|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|kidney(1)|large_intestine(3)|lung(3)|skin(1)|urinary_tract(2)	11	Ovarian(93;0.016)|Breast(50;0.0245)	all_hematologic(90;0.165)	all cancers(50;0.0451)|Epithelial(50;0.0493)			TCGAGGGCCAGAGTGCGCGGG	0.711000													4	21					0	0	1	0	0
GSS	2937	broad.mit.edu	37	20	33533815	33533815	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr20:33533815G>A	ENST00000216951.2	-	3	314	c.216C>T	c.(214-216)ttC>ttT	p.F72F	GSS_ENST00000451957.2_Silent_p.F72F|GSS_ENST00000541098.1_5'UTR	NM_000178.2	NP_000169.1	P48637	GSHB_HUMAN	glutathione synthetase	72					nervous system development|response to oxidative stress|xenobiotic metabolic process	cytosol	ATP binding|glutathione binding|glutathione synthase activity|magnesium ion binding|protein homodimerization activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(6)|ovary(3)|upper_aerodigestive_tract(1)	17			BRCA - Breast invasive adenocarcinoma(18;0.035)		Glutathione(DB00143)|Glycine(DB00145)|L-Cysteine(DB00151)	CTAGCAGGTTGAAGTCCATCT	0.577000													25	71					0	0	1	0	0
HNF1B	6928	broad.mit.edu	37	17	36099443	36099443	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr17:36099443C>T	ENST00000225893.4	-	2	893	c.532G>A	c.(532-534)Gag>Aag	p.E178K	HNF1B_ENST00000561193.1_Missense_Mutation_p.E178K|HNF1B_ENST00000560016.1_Missense_Mutation_p.E178K|HNF1B_ENST00000427275.2_Missense_Mutation_p.E178K	NM_000458.2|NM_001165923.1	NP_000449.1|NP_001159395.1	P35680	HNF1B_HUMAN	HNF1 homeobox B	178					endocrine pancreas development|genitalia development|kidney development|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|pronephric nephron tubule development|regulation of pronephros size	nucleus	DNA binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(6)|kidney(3)|large_intestine(2)|liver(1)|lung(3)|ovary(3)|prostate(1)|skin(2)	28		Breast(25;0.00765)|Ovarian(249;0.15)	STAD - Stomach adenocarcinoma(1;0.0142)			CGGAGGATCTCTCGTTGCTTT	0.552000													16	67					0	0	1	0	0
SESN1	27244	broad.mit.edu	37	6	109415196	109415196	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr6:109415196G>A	ENST00000436639.2	-	1	826	c.81C>T	c.(79-81)aaC>aaT	p.N27N		NM_014454.2	NP_055269.1	Q9Y6P5	SESN1_HUMAN	sestrin 1	83					cell cycle arrest|negative regulation of cell proliferation|response to DNA damage stimulus	nucleus				cervix(1)|large_intestine(3)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	10		all_cancers(87;6.45e-05)|Acute lymphoblastic leukemia(125;3.55e-10)|all_hematologic(75;1.68e-07)|all_epithelial(87;0.0106)|Colorectal(196;0.0637)		Epithelial(106;0.0014)|BRCA - Breast invasive adenocarcinoma(108;0.00146)|all cancers(137;0.0031)|OV - Ovarian serous cystadenocarcinoma(136;0.0117)		TTTGCCTAATGTTTTCCAATG	0.448000													28	82					0	0	1	0	0
KMT2A	4297	broad.mit.edu	37	11	118376222	118376222	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr11:118376222C>T	ENST00000534358.1	+	27	9638	c.9615C>T	c.(9613-9615)agC>agT	p.S3205S	KMT2A_ENST00000389506.5_Silent_p.S3202S|KMT2A_ENST00000354520.4_Silent_p.S3164S	NM_001197104.1|NM_005933.3	NP_001184033.1|NP_005924.2			lysine (K)-specific methyltransferase 2A									p.S3202R(1)									CAGAATCCAGCCAGAGGACAG	0.488000													25	63					0	0	1	0	0
C2orf71	388939	broad.mit.edu	37	2	29293647	29293647	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:29293647C>T	ENST00000331664.5	-	1	3480	c.3481G>A	c.(3481-3483)Gaa>Aaa	p.E1161K		NM_001029883.2	NP_001025054.1	A6NGG8	CB071_HUMAN	chromosome 2 open reading frame 71	1161					response to stimulus|visual perception	photoreceptor outer segment				NS(2)|breast(5)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(2)|prostate(6)|skin(3)|stomach(1)	60						TTCCAGCATTCTGCTGGGTTC	0.622000													16	48					0	0	1	0	0
MEIS1	4211	broad.mit.edu	37	2	66665039	66665039	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:66665039C>T	ENST00000488550.1	+	2	482	c.183C>T	c.(181-183)ccC>ccT	p.P61P	MEIS1_ENST00000444274.2_Silent_p.P29P|MEIS1_ENST00000272369.9_Silent_p.P61P|MEIS1_ENST00000398506.2_Silent_p.P59P|MEIS1_ENST00000560281.2_Silent_p.P61P|MEIS1_ENST00000407092.2_Silent_p.P61P			O00470	MEIS1_HUMAN	Meis homeobox 1	61							sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(10)|prostate(2)|skin(1)|urinary_tract(1)	24						CCATGGCCCCCAGCATGGGCT	0.547000													6	14					0	0	1	0	0
FCGR3B	2215	broad.mit.edu	37	1	161599786	161599786	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:161599786C>G	ENST00000294800.3	-	3	374	c.101G>C	c.(100-102)tGg>tCg	p.W34S	FCGR3B_ENST00000531221.1_Missense_Mutation_p.W70S|FCGR3B_ENST00000367964.2_Missense_Mutation_p.W34S|FCGR2B_ENST00000428605.2_Intron|FCGR3A_ENST00000540048.1_Intron|FCGR2B_ENST00000367960.5_Intron|FCGR2B_ENST00000403078.3_Intron|FCGR2B_ENST00000367962.4_Intron	NM_001244753.1|NM_001271035.1	NP_001231682.1|NP_001257964.1	O75015	FCG3B_HUMAN	Fc fragment of IgG, low affinity IIIb, receptor (CD16b)	34					immune response	anchored to membrane|extracellular region|plasma membrane	IgG binding|receptor activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(9)|prostate(1)|urinary_tract(1)	18	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	CACGCTGTACCATTGAGGCTC	0.532000													17	901					0	0	1	0	0
ZDHHC16	84287	broad.mit.edu	37	10	99215400	99215400	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr10:99215400C>T	ENST00000370846.4	+	6	760	c.598C>T	c.(598-600)Cgc>Tgc	p.R200C	ZDHHC16_ENST00000393760.1_Intron|ZDHHC16_ENST00000353979.3_Intron|ZDHHC16_ENST00000352634.4_Intron|ZDHHC16_ENST00000495735.1_Intron|ZDHHC16_ENST00000345745.5_Intron|ZDHHC16_ENST00000370842.2_Intron|ZDHHC16_ENST00000370854.3_Intron			Q969W1	ZDH16_HUMAN	zinc finger, DHHC-type containing 16	0					apoptosis	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity|zinc ion binding			kidney(4)|large_intestine(3)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	14		Colorectal(252;0.0846)		Epithelial(162;5.81e-10)|all cancers(201;4.19e-08)		CACCAGTCTTCGCCCCTCTTT	0.488000													47	109					0	0	1	0	0
TAAR8	83551	broad.mit.edu	37	6	132874348	132874348	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr6:132874348G>A	ENST00000275200.1	+	1	517	c.517G>A	c.(517-519)Gat>Aat	p.D173N		NM_053278.1	NP_444508.1	Q969N4	TAAR8_HUMAN	trace amine associated receptor 8	173						plasma membrane	G-protein coupled receptor activity			endometrium(3)|large_intestine(2)|lung(14)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	22	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.00412)|GBM - Glioblastoma multiforme(226;0.00792)		AGGTGTCAATGATGATGGGCT	0.468000													51	203					0	0	1	0	0
NCAPG2	54892	broad.mit.edu	37	7	158424360	158424360	+	Nonstop_Mutation	SNP	A	A	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr7:158424360A>C	ENST00000409423.1	-	29	3602	c.3430T>G	c.(3430-3432)Taa>Gaa	p.*1144E	NCAPG2_ENST00000541468.1_Nonstop_Mutation_p.*598E|NCAPG2_ENST00000275830.10_Nonstop_Mutation_p.*889E|NCAPG2_ENST00000356309.3_Nonstop_Mutation_p.*1144E	NM_001281932.1	NP_001268861.1	Q86XI2	CNDG2_HUMAN	non-SMC condensin II complex, subunit G2	0					cell division|chromosome condensation|mitosis	nucleus	methylated histone residue binding			NS(1)|breast(1)|endometrium(5)|kidney(5)|large_intestine(7)|liver(1)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	39	Ovarian(565;0.152)	all_cancers(7;3.44e-11)|all_epithelial(9;3.05e-05)|all_hematologic(28;0.014)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.187)|STAD - Stomach adenocarcinoma(7;0.18)		TGGCTTGGTTATGAATTCAAA	0.299000													17	47					0	0	1	0	0
FOXN2	3344	broad.mit.edu	37	2	48602438	48602438	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:48602438G>A	ENST00000340553.3	+	7	1413	c.1152G>A	c.(1150-1152)aaG>aaA	p.K384K		NM_002158.3	NP_002149.2	P32314	FOXN2_HUMAN	forkhead box N2	384					embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|skin(1)|urinary_tract(1)	13		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.0272)|LUSC - Lung squamous cell carcinoma(58;0.036)			CAGGCAAAAAGATGCGAAAAC	0.438000													14	43					0	0	1	0	0
GAS6	2621	broad.mit.edu	37	13	114523901	114523901	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr13:114523901G>A	ENST00000357389.3	-	15	2254	c.2102C>T	c.(2101-2103)gCg>gTg	p.A701V	GAS6_ENST00000327773.6_Missense_Mutation_p.A658V|GAS6-AS1_ENST00000458001.1_RNA|GAS6_ENST00000418959.3_Missense_Mutation_p.A359V|GAS6_ENST00000355761.4_Missense_Mutation_p.A604V|GAS6_ENST00000450766.1_Missense_Mutation_p.A385V			Q14393	GAS6_HUMAN	growth arrest-specific 6	701	Laminin G-like 2.				cell proliferation|leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|positive regulation of ERK1 and ERK2 cascade|positive regulation of fibroblast proliferation|post-translational protein modification|proteolysis|regulation of growth	endoplasmic reticulum lumen|extracellular space|Golgi lumen|platelet alpha granule lumen	calcium ion binding|receptor agonist activity			central_nervous_system(4)|ovary(1)	5	Lung NSC(43;0.00976)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0176)|all_epithelial(44;0.0104)|all_lung(25;0.0249)|Lung NSC(25;0.0908)|Breast(118;0.188)				CTTGTACGCCGCCTCGTCCAG	0.687000													16	28					0	0	1	0	0
ERC2	26059	broad.mit.edu	37	3	56114897	56114897	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:56114897A>G	ENST00000288221.6	-	7	1844	c.1589T>C	c.(1588-1590)aTg>aCg	p.M530T		NM_015576.1	NP_056391.1	O15083	ERC2_HUMAN	ELKS/RAB6-interacting/CAST family member 2	530						cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			breast(2)|endometrium(5)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|urinary_tract(1)	31				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		CATATCTTTCATGTCACGAAT	0.388000													8	24					0	0	1	0	0
PABPC1	26986	broad.mit.edu	37	8	101721811	101721811	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr8:101721811C>T	ENST00000318607.5	-	8	2249	c.1121G>A	c.(1120-1122)cGc>cAc	p.R374H	PABPC1_ENST00000519004.1_Missense_Mutation_p.R329H|PABPC1_ENST00000522387.1_Missense_Mutation_p.R342H|PABPC1_ENST00000519596.1_5'UTR	NM_002568.3	NP_002559.2	P11940	PABP1_HUMAN	poly(A) binding protein, cytoplasmic 1	374					mRNA polyadenylation|mRNA stabilization|negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|translation	catalytic step 2 spliceosome|cytosol	nucleotide binding|poly(A) RNA binding|protein C-terminus binding|translation activator activity			breast(2)|endometrium(4)|kidney(15)|large_intestine(4)|lung(13)|prostate(1)|skin(1)	40	all_cancers(14;6.8e-05)|all_epithelial(15;3.16e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;6.37e-11)|all cancers(13;1.11e-08)|OV - Ovarian serous cystadenocarcinoma(57;3.91e-05)|STAD - Stomach adenocarcinoma(118;0.206)			GTGAGCCTGGCGCTCTTCTTT	0.498000													28	76					0	0	1	0	0
KIFAP3	22920	broad.mit.edu	37	1	169993564	169993564	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:169993564C>T	ENST00000367765.1	-	9	2396	c.895G>A	c.(895-897)Gat>Aat	p.D299N	KIFAP3_ENST00000367767.1_Missense_Mutation_p.D295N|KIFAP3_ENST00000540905.1_Missense_Mutation_p.D41N|KIFAP3_ENST00000538366.1_Missense_Mutation_p.D261N|KIFAP3_ENST00000361580.2_Missense_Mutation_p.D339N|RP11-332H17.1_ENST00000440321.1_RNA	NM_001204517.1	NP_001191446.1	Q92845	KIFA3_HUMAN	kinesin-associated protein 3	339					blood coagulation|plus-end-directed vesicle transport along microtubule|protein complex assembly|signal transduction	centrosome|condensed nuclear chromosome|cytosol|endoplasmic reticulum|kinesin II complex|spindle microtubule	kinesin binding	p.D339N(1)		endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(18)|prostate(2)|skin(3)|urinary_tract(2)	35	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GTTACCATATCATTTTTATTC	0.313000													12	35					0	0	1	0	0
MAGEB10	139422	broad.mit.edu	37	X	27839619	27839619	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chrX:27839619G>A	ENST00000356790.2	+	3	441	c.196G>A	c.(196-198)Gaa>Aaa	p.E66K		NM_182506.3	NP_872312.2	Q96LZ2	MAGBA_HUMAN	melanoma antigen family B, 10	66										NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	26						TGGACTTCGGGAAGCCCAATC	0.502000													15	17					0	0	1	0	0
IARS	3376	broad.mit.edu	37	9	95043169	95043169	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr9:95043169G>C	ENST00000375643.3	-	7	870	c.604C>G	c.(604-606)Caa>Gaa	p.Q202E	IARS_ENST00000447699.2_Missense_Mutation_p.Q92E|IARS_ENST00000443024.2_Missense_Mutation_p.Q202E|IARS_ENST00000375629.3_5'UTR	NM_013417.2	NP_038203.2	P41252	SYIC_HUMAN	isoleucyl-tRNA synthetase	202					isoleucyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	ATP binding|isoleucine-tRNA ligase activity|protein binding			breast(3)|endometrium(2)|kidney(4)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	35					L-Isoleucine(DB00167)	GAAGGATCTTGAACATCCTGA	0.353000													4	24					0	0	1	0	0
MSI2	124540	broad.mit.edu	37	17	55729481	55729481	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr17:55729481G>A	ENST00000284073.2	+	11	958	c.749G>A	c.(748-750)gGa>gAa	p.G250E	MSI2_ENST00000579505.1_3'UTR|MSI2_ENST00000416426.2_Missense_Mutation_p.G228E|MSI2_ENST00000442934.2_Missense_Mutation_p.G189E	NM_138962.2	NP_620412.1	Q96DH6	MSI2H_HUMAN	musashi RNA-binding protein 2	250						cytoplasm	nucleotide binding|RNA binding			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|ovary(1)|pancreas(1)|skin(1)	7	Breast(9;1.78e-08)			GBM - Glioblastoma multiforme(1;0.0025)		GCGGCTTATGGACCAGTGGCA	0.632000			T	HOXA9	CML								29	45					0	0	1	0	0
LAMB2	3913	broad.mit.edu	37	3	49166566	49166566	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:49166566G>A	ENST00000418109.1	-	14	1782	c.1618C>T	c.(1618-1620)Caa>Taa	p.Q540*	LAMB2_ENST00000305544.4_Nonsense_Mutation_p.Q540*	NM_002292.3	NP_002283.3	P55268	LAMB2_HUMAN	laminin, beta 2 (laminin S)	540	Laminin EGF-like 5; truncated.				cell adhesion	laminin-11 complex|laminin-3 complex	structural molecule activity			NS(1)|breast(1)|endometrium(15)|kidney(3)|large_intestine(6)|lung(21)|ovary(4)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		CAGTGGCATTGACCTGTGCCC	0.577000													17	59					0	0	1	0	0
IFI27L1	122509	broad.mit.edu	37	14	94563266	94563266	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr14:94563266G>A	ENST00000553664.1	+	3	175	c.50G>A	c.(49-51)cGa>cAa	p.R17Q	IFI27L1_ENST00000554544.1_5'UTR|IFI27L1_ENST00000556381.1_5'UTR|IFI27L1_ENST00000554562.1_5'UTR|IFI27L1_ENST00000557218.1_5'UTR|IFI27L1_ENST00000393115.3_5'UTR|IFI27L1_ENST00000553350.1_3'UTR|IFI27L1_ENST00000557066.1_5'UTR|IFI27L1_ENST00000555523.1_5'UTR			Q96BM0	I27L1_HUMAN	interferon, alpha-inducible protein 27-like 1	0						integral to membrane				lung(2)	2						GAGGCTCACCGAGGCGAAGGG	0.502000													10	4					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144917854	144917854	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:144917854G>A	ENST00000529945.1	-	7	2360	c.1921C>T	c.(1921-1923)Cgc>Tgc	p.R641C	PDE4DIP_ENST00000369359.4_Missense_Mutation_p.R615C|PDE4DIP_ENST00000530740.1_Missense_Mutation_p.R615C|PDE4DIP_ENST00000369351.3_Missense_Mutation_p.R478C|PDE4DIP_ENST00000479408.2_Missense_Mutation_p.R265C|PDE4DIP_ENST00000369354.3_Missense_Mutation_p.R478C|PDE4DIP_ENST00000369356.4_Missense_Mutation_p.R478C|PDE4DIP_ENST00000313382.9_Missense_Mutation_p.R544C|PDE4DIP_ENST00000313431.9_Missense_Mutation_p.R641C|PDE4DIP_ENST00000369349.3_Missense_Mutation_p.R478C			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	478					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		ATTCGCTGGCGAAGTTTCTCA	0.378000			T	PDGFRB	MPD								43	576					0	0	1	0	0
GRAMD2	196996	broad.mit.edu	37	15	72455648	72455648	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr15:72455648C>T	ENST00000309731.7	-	10	928	c.915G>A	c.(913-915)ctG>ctA	p.L305L	GRAMD2_ENST00000564184.1_5'UTR	NM_001012642.2	NP_001012660.1	Q8IUY3	GRAM2_HUMAN	GRAM domain containing 2	305						integral to membrane		p.L305L(1)		cervix(2)|endometrium(1)|large_intestine(4)|lung(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	13						CCCAGAGCCTCAGCTCCCCAG	0.562000													16	25					0	0	1	0	0
HDAC6	10013	broad.mit.edu	37	X	48681429	48681429	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chrX:48681429G>T	ENST00000334136.5	+	25	2798	c.2620G>T	c.(2620-2622)Gtt>Ttt	p.V874F	HDAC6_ENST00000376619.2_Missense_Mutation_p.V874F|HDAC6_ENST00000444343.2_Missense_Mutation_p.V888F			Q9UBN7	HDAC6_HUMAN	histone deacetylase 6	874					aggresome assembly|cellular response to hydrogen peroxide|Hsp90 deacetylation|lysosome localization|macroautophagy|misfolded or incompletely synthesized protein catabolic process|negative regulation of proteolysis|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|polyubiquitinated misfolded protein transport|positive regulation of apoptosis|positive regulation of cellular chaperone-mediated protein complex assembly|positive regulation of epithelial cell migration|positive regulation of receptor biosynthetic process|positive regulation of signal transduction|regulation of androgen receptor signaling pathway|regulation of receptor activity|response to growth factor stimulus|response to toxin|transcription, DNA-dependent|tubulin deacetylation	aggresome|caveola|cell leading edge|cytosol|histone deacetylase complex|microtubule associated complex|perinuclear region of cytoplasm	actin binding|alpha-tubulin binding|beta-catenin binding|dynein complex binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|Hsp90 protein binding|microtubule binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|polyubiquitin binding|tau protein binding|tubulin deacetylase activity|zinc ion binding			breast(2)|endometrium(6)|kidney(5)|large_intestine(8)|lung(9)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	40					Vorinostat(DB02546)	AGAAAAGAAGGTTCTGGAAGC	0.542000													9	15					1.12685e-05	1.16546e-05	1	1	0
GDPD3	79153	broad.mit.edu	37	16	30123629	30123629	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr16:30123629C>T	ENST00000406256.3	-	5	858	c.481G>A	c.(481-483)Gag>Aag	p.E161K		NM_024307.2	NP_077283.2	Q7L5L3	GDPD3_HUMAN	glycerophosphodiester phosphodiesterase domain containing 3	161	GDPD.				glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding			biliary_tract(1)|breast(1)|central_nervous_system(1)|large_intestine(2)|lung(6)	11						AGCACCACCTCACGGATGAGC	0.612000											OREG0023731	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	31	83					0	0	1	0	0
ERCC6L	54821	broad.mit.edu	37	X	71428441	71428441	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chrX:71428441C>G	ENST00000334463.3	-	2	311	c.176G>C	c.(175-177)aGa>aCa	p.R59T	ERCC6L_ENST00000373657.1_5'UTR|PIN4_ENST00000423432.2_Intron	NM_017669.2	NP_060139.2	Q2NKX8	ERC6L_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 6-like	59					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol	ATP binding|DNA binding|helicase activity|protein binding			breast(2)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(9)|lung(9)|ovary(3)|skin(1)	38	Renal(35;0.156)					TTTTTGGATTCTGCTCAGCAC	0.408000													13	51					0	0	1	0	0
MIR21	406991	broad.mit.edu	37	17	57918683	57918683	+	RNA	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr17:57918683G>C	ENST00000362134.1	+	0	57					NR_029493.1																						AACACCAGTCGATGGGCTGTC	0.423000													76	80					0	0	1	0	0
CPNE5	57699	broad.mit.edu	37	6	36724064	36724064	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr6:36724064C>T	ENST00000244751.2	-	13	1491	c.867G>A	c.(865-867)ccG>ccA	p.P289P	CPNE5_ENST00000459703.1_5'UTR|CPNE5_ENST00000393189.2_5'UTR	NM_020939.1	NP_065990.1	Q9HCH3	CPNE5_HUMAN	copine V	289										central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(4)|liver(1)|lung(9)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25						TTTTCTTTTTCGGGTTTACCA	0.522000													15	29					0	0	1	0	0
IRF2BP1	26145	broad.mit.edu	37	19	46388283	46388283	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:46388283G>A	ENST00000302165.3	-	1	1093	c.750C>T	c.(748-750)caC>caT	p.H250H		NM_015649.1	NP_056464.1	Q8IU81	I2BP1_HUMAN	interferon regulatory factor 2 binding protein 1	250				H -> R (in Ref. 2; BAD97342).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				cervix(1)|kidney(1)|lung(2)	4		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00442)|GBM - Glioblastoma multiforme(486;0.0402)|Epithelial(262;0.231)		CCACCAGCCCGTGATCCTTCT	0.632000													18	66					0	0	1	0	0
RRM2B	50484	broad.mit.edu	37	8	103226331	103226331	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr8:103226331G>A	ENST00000251810.3	-	7	983	c.740C>T	c.(739-741)tCa>tTa	p.S247L	RRM2B_ENST00000519962.1_Intron|RRM2B_ENST00000395912.2_Missense_Mutation_p.S195L|RRM2B_ENST00000519317.1_Missense_Mutation_p.S35L	NM_001172478.1|NM_015713.4	NP_001165949.1|NP_056528.2	Q7LG56	RIR2B_HUMAN	ribonucleotide reductase M2 B (TP53 inducible)	247					deoxyribonucleoside diphosphate metabolic process|DNA repair|nucleobase, nucleoside and nucleotide interconversion	nucleoplasm	ribonucleoside-diphosphate reductase activity|transition metal ion binding			breast(1)|endometrium(1)|large_intestine(1)|lung(3)|ovary(2)|upper_aerodigestive_tract(1)	9	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000728)			CCTTTCTTCTGAAGGCTTATT	0.383000								Modulation of nucleotide pools					9	19					0	0	1	0	0
PSD2	84249	broad.mit.edu	37	5	139192916	139192916	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr5:139192916G>A	ENST00000274710.3	+	3	599	c.394G>A	c.(394-396)Gat>Aat	p.D132N		NM_032289.2	NP_115665.1	Q9BQI7	PSD2_HUMAN	pleckstrin and Sec7 domain containing 2	132					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(10)|liver(2)|lung(15)|ovary(1)|prostate(2)	38			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGGGGAGCCAGATGTGCGGGA	0.602000													35	60					0	0	1	0	0
HACL1	26061	broad.mit.edu	37	3	15604909	15604909	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:15604909G>A	ENST00000321169.5	-	16	2027	c.1660C>T	c.(1660-1662)Ctt>Ttt	p.L554F	HACL1_ENST00000435217.2_Missense_Mutation_p.L313F|HACL1_ENST00000451445.2_Missense_Mutation_p.L472F|HACL1_ENST00000457447.2_Missense_Mutation_p.L494F|HACL1_ENST00000456194.2_Missense_Mutation_p.L527F	NM_012260.2	NP_036392.2	Q9UJ83	HACL1_HUMAN	2-hydroxyacyl-CoA lyase 1	554					fatty acid alpha-oxidation	peroxisomal matrix	carbon-carbon lyase activity|identical protein binding|magnesium ion binding|thiamine pyrophosphate binding			NS(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(3)|skin(1)	16						ATGTTGATAAGAGAAGGTTTA	0.458000													8	40					0	0	1	0	0
MFSD11	79157	broad.mit.edu	37	17	74750140	74750140	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr17:74750140A>G	ENST00000588460.1	+	8	2695	c.653A>G	c.(652-654)aAc>aGc	p.N218S	MFSD11_ENST00000586622.1_Missense_Mutation_p.N218S|MFSD11_ENST00000590514.1_Missense_Mutation_p.N218S|MFSD11_ENST00000355954.3_Missense_Mutation_p.N166S|MFSD11_ENST00000336509.4_Missense_Mutation_p.N218S|MFSD11_ENST00000593181.1_Missense_Mutation_p.N166S	NM_001242534.1	NP_001229463.1	O43934	MFS11_HUMAN	major facilitator superfamily domain containing 11	218						integral to membrane				endometrium(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(2)|prostate(1)|skin(1)	17						TCTGCCCAGAACAATCTGACA	0.328000													12	22					0	0	1	0	0
KIAA1614	57710	broad.mit.edu	37	1	180904388	180904388	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:180904388C>T	ENST00000367588.4	+	5	1398	c.1343C>T	c.(1342-1344)tCg>tTg	p.S448L	KIAA1614_ENST00000367587.1_Missense_Mutation_p.S69L	NM_020950.1	NP_066001.1	Q5VZ46	K1614_HUMAN	KIAA1614	448										NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(12)|ovary(5)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	33						CCCTCGCCGTCGCACGTGCGC	0.697000													4	5					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145311916	145311916	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:145311916A>G	ENST00000369338.1	+	10	1355	c.1165A>G	c.(1165-1167)Ata>Gta	p.I389V	RP11-458D21.5_ENST00000468030.1_Intron|NBPF10_ENST00000369339.3_Intron|NBPF10_ENST00000342960.5_Intron			A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	662								p.I389V(3)|p.Y388>?(1)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		TGCCTTTTACATATTGGAGCA	0.458000													6	616					0	0	1	0	0
PROL1	58503	broad.mit.edu	37	4	71275125	71275125	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr4:71275125G>A	ENST00000399575.2	+	3	254	c.80G>A	c.(79-81)aGa>aAa	p.R27K	PROL1_ENST00000514338.1_3'UTR	NM_021225.4	NP_067048.4	Q99935	PROL1_HUMAN	proline rich, lacrimal 1	27					regulation of sensory perception of pain	extracellular region	endopeptidase inhibitor activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)|skin(3)	15		all_hematologic(202;0.196)				TTCTCCAGAAGACCATATCTA	0.423000													23	48					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23894580	23894580	+	Silent	SNP	G	G	A	rs2069544	byFrequency	TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr14:23894580G>A	ENST00000355349.3	-	21	2496	c.2334C>T	c.(2332-2334)gaC>gaT	p.D778D		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	778	Myosin head-like.		D -> E (in CMH1).|D -> G (in CMH1).|D -> V (in CMH1).		adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		TCAGCCTCTCGTCCCTCATTT	0.587000													13	42					0	0	1	0	0
PRRX1	5396	broad.mit.edu	37	1	170699465	170699465	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:170699465G>A	ENST00000367760.3	+	4	1732	c.647G>A	c.(646-648)gGa>gAa	p.G216E	PRRX1_ENST00000239461.6_Intron|PRRX1_ENST00000476867.2_Intron	NM_006902.3	NP_008833.1	P54821	PRRX1_HUMAN	paired related homeobox 1	0						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			large_intestine(2)|ovary(1)	3	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CTTCATAACGGATTCTAACGG	0.453000													31	115					0	0	1	0	0
IQCH	64799	broad.mit.edu	37	15	67629410	67629410	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr15:67629410T>C	ENST00000335894.4	+	5	551	c.485T>C	c.(484-486)gTc>gCc	p.V162A	IQCH_ENST00000546225.1_5'UTR|IQCH_ENST00000358767.3_5'UTR	NM_001031715.2	NP_001026885	Q86VS3	IQCH_HUMAN	IQ motif containing H	162										NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(2)|pancreas(2)|skin(5)|upper_aerodigestive_tract(1)	33				Colorectal(3;0.0856)		CCTATACCAGTCTTACAAGCA	0.423000													16	48					0	0	1	0	0
UNC13D	201294	broad.mit.edu	37	17	73839263	73839263	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr17:73839263C>T	ENST00000207549.4	-	3	617	c.238G>A	c.(238-240)Gag>Aag	p.E80K	UNC13D_ENST00000587504.1_5'UTR|UNC13D_ENST00000412096.2_Missense_Mutation_p.E80K	NM_199242.2	NP_954712.1	Q70J99	UN13D_HUMAN	unc-13 homolog D (C. elegans)	80					positive regulation of exocytosis|regulation of mast cell degranulation	exocytic vesicle|late endosome|lysosome|membrane|recycling endosome	protein binding			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29			all cancers(21;2.11e-06)|Epithelial(20;2.32e-06)|BRCA - Breast invasive adenocarcinoma(9;0.000618)|LUSC - Lung squamous cell carcinoma(166;0.154)			CGCAGCAGCTCAGAGGCCTCC	0.672000									Familial Hemophagocytic Lymphohistiocytosis				18	43					0	0	1	0	0
MALT1	10892	broad.mit.edu	37	18	56377292	56377292	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr18:56377292G>C	ENST00000348428.3	+	6	1171	c.913G>C	c.(913-915)Gaa>Caa	p.E305Q	RP11-126O1.4_ENST00000588835.1_RNA|MALT1_ENST00000345724.3_Missense_Mutation_p.E305Q	NM_006785.2|NM_173844.1	NP_006776.1|NP_776216.1	Q9UDY8	MALT1_HUMAN	mucosa associated lymphoid tissue lymphoma translocation gene 1	305	Ig-like C2-type 2.				activation of NF-kappaB-inducing kinase activity|anti-apoptosis|nuclear export|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of protein ubiquitination|positive regulation of T cell cytokine production|protein oligomerization|proteolysis|T cell receptor signaling pathway	CBM complex|cytosol|nucleus|perinuclear region of cytoplasm	cysteine-type endopeptidase activity|protein self-association|signal transducer activity|ubiquitin-protein ligase activity			central_nervous_system(1)|large_intestine(7)|lung(1)|ovary(2)|skin(1)	12						CAAGAAGGTAGAAATCATCAT	0.343000			T	BIRC3	MALT								17	45					0	0	1	0	0
MEGF8	1954	broad.mit.edu	37	19	42865107	42865107	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:42865107G>A	ENST00000334370.4	+	31	6103	c.5468G>A	c.(5467-5469)gGg>gAg	p.G1823E	MEGF8_ENST00000251268.6_Missense_Mutation_p.G1890E	NM_001410.2	NP_001401.2	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	1890						integral to membrane	calcium ion binding|structural molecule activity			breast(2)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	50		Prostate(69;0.00682)				AACCAGTCTGGGGCCTGCACC	0.672000													33	30					0	0	1	0	0
C5orf55	116349	broad.mit.edu	37	5	442648	442648	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr5:442648C>T	ENST00000408966.2	-	1	610	c.290G>A	c.(289-291)aGa>aAa	p.R97K		NM_138464.2	NP_612473.1	Q8N2X6	CE055_HUMAN	chromosome 5 open reading frame 55	97						extracellular region				large_intestine(1)|lung(2)	3						TGCTGGGCCTCTGAGGGGCCC	0.647000													20	1263					0	0	1	0	0
CRTC1	23373	broad.mit.edu	37	19	18864341	18864341	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:18864341G>C	ENST00000338797.6	+	7	643	c.618G>C	c.(616-618)gaG>gaC	p.E206D	CRTC1_ENST00000321949.8_Missense_Mutation_p.E190D|CRTC1_ENST00000601916.1_Missense_Mutation_p.E115D|CRTC1_ENST00000594658.1_Missense_Mutation_p.E149D	NM_001098482.1	NP_001091952.1	Q6UUV9	CRTC1_HUMAN	CREB regulated transcription coactivator 1	190					interspecies interaction between organisms|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	cAMP response element binding protein binding|protein binding		CRTC1/MAML2(516)	NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|skin(1)	19						GAATGGAAGAGACCACATCAG	0.463000													65	213					0	0	1	0	0
MYO3A	53904	broad.mit.edu	37	10	26482183	26482183	+	Silent	SNP	C	C	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr10:26482183C>A	ENST00000265944.5	+	32	4654	c.4488C>A	c.(4486-4488)ccC>ccA	p.P1496P	MYO3A_ENST00000543632.1_Intron	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	1496					protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						CAAGACGACCCCGGAAACCCA	0.378000													18	27					0.000175454	0.000179734	1	1	0
TMEM131	23505	broad.mit.edu	37	2	98409038	98409038	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:98409038C>T	ENST00000186436.5	-	31	4183	c.3955G>A	c.(3955-3957)Gaa>Aaa	p.E1319K		NM_015348.1	NP_056163.1	Q92545	TM131_HUMAN	transmembrane protein 131	1319	Pro-rich.					integral to membrane		p.E1206Q(1)|p.E1206*(1)|p.E1319Q(1)		NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(4)|prostate(1)|skin(1)|stomach(1)	57						GACAGCCTTTCAGGCTGCGGC	0.677000													8	27					0	0	1	0	0
MAU2	23383	broad.mit.edu	37	19	19448017	19448017	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:19448017G>A	ENST00000262815.8	+	4	438	c.399G>A	c.(397-399)gcG>gcA	p.A133A	MAU2_ENST00000586189.3_3'UTR|MAU2_ENST00000392313.6_Silent_p.A133A			Q9Y6X3	SCC4_HUMAN	MAU2 sister chromatid cohesion factor	133					cell division|maintenance of mitotic sister chromatid cohesion	chromatin|nucleoplasm|SMC loading complex	protein N-terminus binding			NS(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	18						TGCGGAAGGCGATCCAGATCT	0.552000													14	32					0	0	1	0	0
WDR33	55339	broad.mit.edu	37	2	128467099	128467099	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:128467099C>T	ENST00000322313.4	-	20	3688	c.3530G>A	c.(3529-3531)cGg>cAg	p.R1177Q		NM_018383.4	NP_060853.3	Q9C0J8	WDR33_HUMAN	WD repeat domain 33	1177					postreplication repair|spermatogenesis	collagen|nucleus	protein binding			NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(9)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		ATCTGGCTTCCGCCCTCCTTC	0.517000													34	101					0	0	1	0	0
IRS1	3667	broad.mit.edu	37	2	227661432	227661432	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:227661432T>C	ENST00000305123.5	-	1	3043	c.2023A>G	c.(2023-2025)Att>Gtt	p.I675V		NM_005544.2	NP_005535.1	P35568	IRS1_HUMAN	insulin receptor substrate 1						fibroblast growth factor receptor signaling pathway|glucose homeostasis|insulin receptor signaling pathway|negative regulation of insulin receptor signaling pathway|negative regulation of insulin secretion|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity	caveola|cytosol|insulin receptor complex|microsome|nucleus	insulin receptor binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase binding|protein kinase C binding|SH2 domain binding|transmembrane receptor protein tyrosine kinase adaptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(5)|kidney(4)|large_intestine(10)|lung(33)|ovary(6)|pancreas(1)|prostate(1)|urinary_tract(2)	69		Renal(207;0.023)|all_lung(227;0.0994)|all_hematologic(139;0.118)|Esophageal squamous(248;0.23)		Epithelial(121;3.03e-11)|all cancers(144;2.42e-08)|Lung(261;0.00712)|LUSC - Lung squamous cell carcinoma(224;0.0137)		CCACCTCCAATGTCAGGAGAG	0.617000											OREG0015248	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	27	26					0	0	1	0	0
PHKB	5257	broad.mit.edu	37	16	47684750	47684750	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr16:47684750G>A	ENST00000455779.1	+	21	2053	c.1868G>A	c.(1867-1869)cGg>cAg	p.R623Q	PHKB_ENST00000323584.5_Missense_Mutation_p.R630Q|PHKB_ENST00000299167.8_Missense_Mutation_p.R630Q|PHKB_ENST00000566044.1_Missense_Mutation_p.R623Q			Q93100	KPBB_HUMAN	phosphorylase kinase, beta	630					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|liver(1)|lung(18)|ovary(1)|skin(1)	41		all_cancers(37;0.00447)|all_lung(18;0.00616)|Lung NSC(13;0.0418)|Breast(268;0.203)				AGAGGTAGCCGGTTCAACCCC	0.333000													36	22					0	0	1	0	0
KLHL42	57542	broad.mit.edu	37	12	27933917	27933917	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr12:27933917C>T	ENST00000381271.2	+	1	965	c.654C>T	c.(652-654)tcC>tcT	p.S218S	RP11-860B13.1_ENST00000545904.1_RNA	NM_020782.1	NP_065833.1			kelch-like family member 42																		AGCCCCCGTCCATGCTCAGGT	0.662000													9	19					0	0	1	0	0
MMP1	4312	broad.mit.edu	37	11	102667496	102667496	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr11:102667496T>A	ENST00000315274.6	-	4	591	c.524A>T	c.(523-525)gAt>gTt	p.D175V	WTAPP1_ENST00000525739.2_RNA	NM_001145938.1|NM_002421.3	NP_001139410.1|NP_002412.1	P03956	MMP1_HUMAN	matrix metallopeptidase 1 (interstitial collagenase)	175	Metalloprotease.				blood coagulation|collagen catabolic process|interspecies interaction between organisms|leukocyte migration|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(1)|large_intestine(2)|lung(18)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	30	all_epithelial(12;0.0127)	all_neural(303;0.000318)|all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.072)|Lung(13;0.0828)|LUSC - Lung squamous cell carcinoma(19;0.151)|all cancers(10;0.233)	OV - Ovarian serous cystadenocarcinoma(223;1.82e-07)|Epithelial(105;1.51e-06)|BRCA - Breast invasive adenocarcinoma(274;0.014)		TCCAGGTCCATCAAAAGGAGA	0.428000													12	40					0	0	1	0	0
OLFM2	93145	broad.mit.edu	37	19	9968519	9968519	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:9968519A>G	ENST00000264833.4	-	3	417	c.232T>C	c.(232-234)Tcc>Ccc	p.S78P	OLFM2_ENST00000590841.1_5'UTR	NM_058164.2	NP_477512.1	O95897	NOE2_HUMAN	olfactomedin 2	78						extracellular region				breast(1)|cervix(1)|endometrium(3)|large_intestine(8)|lung(9)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)	31						ACCTCCATGGACTGGGAGACG	0.602000													10	27					0	0	1	0	0
GNA11	2767	broad.mit.edu	37	19	3121021	3121021	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:3121021C>T	ENST00000078429.4	+	7	1166	c.924C>T	c.(922-924)ttC>ttT	p.F308F	GNA11_ENST00000586180.1_3'UTR	NM_002067.2	NP_002058.2	P29992	GNA11_HUMAN	guanine nucleotide binding protein (G protein), alpha 11 (Gq class)	308					activation of phospholipase C activity by dopamine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|protein ADP-ribosylation|regulation of action potential	cytoplasm|heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			endometrium(2)|eye(132)|kidney(1)|large_intestine(2)|lung(1)|meninges(5)|ovary(1)|prostate(1)|skin(16)	161		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.79e-05)|OV - Ovarian serous cystadenocarcinoma(105;2.68e-113)|Epithelial(107;1.22e-111)|all cancers(105;5.78e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00141)|STAD - Stomach adenocarcinoma(1328;0.181)		CGCGGGAGTTCATCCTGAAGA	0.657000			Mis		uveal melanoma								13	27					0	0	1	0	0
OR2T3	343173	broad.mit.edu	37	1	248636950	248636950	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:248636950C>T	ENST00000359594.2	+	1	324	c.299C>T	c.(298-300)tCa>tTa	p.S100L		NM_001005495.1	NP_001005495.1	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T, member 3	100					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(5)|lung(19)|ovary(1)|prostate(1)|skin(3)	31	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ATTTCCCCGTCAGGCTGTGGG	0.547000													11	93					0	0	1	0	0
CCDC85A	114800	broad.mit.edu	37	2	56419820	56419820	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:56419820A>G	ENST00000407595.2	+	2	987	c.485A>G	c.(484-486)aAc>aGc	p.N162S	RP11-482H16.1_ENST00000607540.1_RNA	NM_001080433.1	NP_001073902.1	Q96PX6	CC85A_HUMAN	coiled-coil domain containing 85A	162										breast(6)|cervix(2)|endometrium(5)|kidney(1)|lung(18)|ovary(2)|pancreas(1)|prostate(3)	38			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			GTGAAGGAGAACATGGAGCTC	0.587000													43	66					0	0	1	0	0
PHLDB2	90102	broad.mit.edu	37	3	111603689	111603689	+	Silent	SNP	A	A	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:111603689A>G	ENST00000431670.2	+	2	1176	c.765A>G	c.(763-765)tcA>tcG	p.S255S	PHLDB2_ENST00000393923.3_Silent_p.S282S|PHLDB2_ENST00000477695.1_Silent_p.S255S|PHLDB2_ENST00000478922.1_Silent_p.S255S|PHLDB2_ENST00000393925.3_Silent_p.S255S|PHLDB2_ENST00000412622.1_Silent_p.S255S|PHLDB2_ENST00000481953.1_Silent_p.S255S	NM_001134438.1	NP_001127910.1	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B, member 2	255						cytoplasm|intermediate filament cytoskeleton|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(7)|large_intestine(8)|lung(23)|ovary(6)|skin(7)|stomach(1)	55						ACAGCCGATCACTTCCCAGGT	0.483000													48	52					0	0	1	0	0
C2orf57	165100	broad.mit.edu	37	2	232458278	232458278	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:232458278G>A	ENST00000313965.2	+	1	704	c.616G>A	c.(616-618)Gaa>Aaa	p.E206K		NM_152614.2	NP_689827.2	Q53QW1	CB057_HUMAN	chromosome 2 open reading frame 57	206										endometrium(1)|kidney(2)|large_intestine(1)|lung(7)|ovary(1)|pancreas(1)|prostate(4)|skin(2)	19		Renal(207;0.025)|all_hematologic(139;0.0735)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;1.33e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.014)		CCCACACCCTGAAGCTGAAGC	0.577000													7	70					0	0	1	0	0
ZNF212	7988	broad.mit.edu	37	7	148951224	148951224	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr7:148951224C>T	ENST00000335870.2	+	5	1334	c.1206C>T	c.(1204-1206)gtC>gtT	p.V402V		NM_012256.3	NP_036388.2	Q9UDV6	ZN212_HUMAN	zinc finger protein 212	402					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|identical protein binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(4)|ovary(1)|prostate(1)	9	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)			GCCAGCATGTCCAAGAGAGGT	0.597000													6	22					0	0	1	0	0
ANO8	57719	broad.mit.edu	37	19	17435910	17435910	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:17435910G>C	ENST00000159087.4	-	17	3105	c.2947C>G	c.(2947-2949)Cca>Gca	p.P983A		NM_020959.2	NP_066010.1	Q9HCE9	ANO8_HUMAN	anoctamin 8	983						chloride channel complex	chloride channel activity			autonomic_ganglia(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|ovary(4)|pancreas(1)|prostate(2)|urinary_tract(3)	27						CCCTGCAGTGGGATGATCTGC	0.672000													35	130					0	0	1	0	0
NOC3L	64318	broad.mit.edu	37	10	96117057	96117057	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr10:96117057C>T	ENST00000371361.3	-	4	482	c.382G>A	c.(382-384)Gaa>Aaa	p.E128K	NOC3L_ENST00000371350.1_Missense_Mutation_p.E128K|NOC3L_ENST00000463649.1_5'UTR	NM_022451.9	NP_071896.8	Q8WTT2	NOC3L_HUMAN	nucleolar complex associated 3 homolog (S. cerevisiae)	128						nuclear speck|nucleolus	binding			endometrium(3)|large_intestine(17)|lung(5)|ovary(1)|skin(2)|stomach(1)	29		Colorectal(252;0.0897)				ATAATGCGTTCATGCTTCCGT	0.343000													13	32					0	0	1	0	0
TUBB4B	10383	broad.mit.edu	37	9	140136952	140136952	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr9:140136952G>C	ENST00000340384.4	+	4	430	c.282G>C	c.(280-282)caG>caC	p.Q94H		NM_006088.5	NP_006079.1	P68371	TBB2C_HUMAN	tubulin, beta 4B class IVb	94					'de novo' posttranslational protein folding|cellular component movement|G2/M transition of mitotic cell cycle|microtubule-based movement|natural killer cell mediated cytotoxicity|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|MHC class I protein binding|structural molecule activity|unfolded protein binding										TCACAGGTCAGAGTGGTGCTG	0.557000													17	48					0	0	1	0	0
NEK3	4752	broad.mit.edu	37	13	52718874	52718874	+	Silent	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr13:52718874G>C	ENST00000400357.2	-	8	2049	c.756C>G	c.(754-756)ctC>ctG	p.L252L	NEK3_ENST00000339406.3_Silent_p.L252L|NEK3_ENST00000378101.2_Silent_p.L252L|NEK3_ENST00000452082.2_Silent_p.L273L			P51956	NEK3_HUMAN	NIMA-related kinase 3	252	Interaction with VAV2.|Protein kinase.				cell division|mitosis	nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(3)|ovary(1)|prostate(1)|stomach(2)	18		Breast(56;0.000207)|Lung NSC(96;0.00145)|Prostate(109;0.034)|Hepatocellular(98;0.065)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.81e-08)		TGCCTCGAGAGAGAAGCGTTG	0.478000													5	18					0	0	1	0	0
ITIH1	3697	broad.mit.edu	37	3	52818337	52818337	+	Silent	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:52818337C>G	ENST00000273283.2	+	11	1275	c.1251C>G	c.(1249-1251)ctC>ctG	p.L417L	ITIH1_ENST00000540715.1_Silent_p.L275L|ITIH1_ENST00000537050.1_Silent_p.L129L|ITIH1_ENST00000542827.1_Silent_p.L417L	NM_002215.3	NP_002206.2	P19827	ITIH1_HUMAN	inter-alpha-trypsin inhibitor heavy chain 1	417	Hyaluronan-binding.|VWFA.				hyaluronan metabolic process|leukocyte activation	extracellular region	calcium ion binding|serine-type endopeptidase inhibitor activity	p.L417L(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(16)|lung(18)|ovary(4)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	52				BRCA - Breast invasive adenocarcinoma(193;7.04e-05)|Kidney(197;0.000659)|KIRC - Kidney renal clear cell carcinoma(197;0.000795)|OV - Ovarian serous cystadenocarcinoma(275;0.0498)		CCCAAATCCTCAAGAACGTCC	0.602000													6	20					0	0	1	0	0
UNC13A	23025	broad.mit.edu	37	19	17752296	17752296	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:17752296C>T	ENST00000428389.2	-	22	2805	c.2806G>A	c.(2806-2808)Gat>Aat	p.D936N	UNC13A_ENST00000552293.1_Missense_Mutation_p.D848N|UNC13A_ENST00000519716.2_Missense_Mutation_p.D848N|UNC13A_ENST00000252773.7_Missense_Mutation_p.D848N|UNC13A_ENST00000551649.1_Missense_Mutation_p.D848N|UNC13A_ENST00000550896.1_Missense_Mutation_p.D846N			Q9UPW8	UN13A_HUMAN	unc-13 homolog A (C. elegans)	848					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding	p.D848N(1)		breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|prostate(2)	61						TTCCAGGCATCGTCACCCTTG	0.547000													19	67					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20996984	20996984	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr16:20996984G>T	ENST00000261383.3	-	48	7079	c.7080C>A	c.(7078-7080)agC>agA	p.S2360R	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2360					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		CAAAGAAGAGGCTTCGAATGT	0.453000													69	110					1.17253e-29	1.27409e-29	1	1	0
PNRC1	10957	broad.mit.edu	37	6	89790641	89790641	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr6:89790641G>A	ENST00000336032.3	+	1	145	c.28G>A	c.(28-30)Gag>Aag	p.E10K	PNRC1_ENST00000369472.1_5'UTR	NM_006813.2	NP_006804.1	Q12796	PNRC1_HUMAN	proline-rich nuclear receptor coactivator 1	10					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			endometrium(1)|large_intestine(2)|lung(3)	6		all_cancers(76;3.64e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00527)		BRCA - Breast invasive adenocarcinoma(108;0.102)		CCCGCAGCGGGAGCCGCTCGT	0.617000										Multiple Myeloma(7;0.094)			6	44					0	0	1	0	0
ACSS3	79611	broad.mit.edu	37	12	81536974	81536974	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr12:81536974C>T	ENST00000548058.1	+	5	1779	c.869C>T	c.(868-870)tCa>tTa	p.S290L	ACSS3_ENST00000261206.3_Missense_Mutation_p.S289L			Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	290						mitochondrion	acetate-CoA ligase activity|ATP binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(7)|liver(3)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)	51						CCTGTTCTTTCAGAACACCCA	0.453000													30	34					0	0	1	0	0
ARPP19	10776	broad.mit.edu	37	15	52844256	52844256	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr15:52844256T>G	ENST00000566423.1	-	4	347	c.214A>C	c.(214-216)Atg>Ctg	p.M72L	ARPP19_ENST00000564163.1_Missense_Mutation_p.M91L|ARPP19_ENST00000561650.1_Missense_Mutation_p.M56L|ARPP19_ENST00000569723.1_Missense_Mutation_p.M31L|ARPP19_ENST00000563566.1_Missense_Mutation_p.M56L|ARPP19_ENST00000569281.2_Missense_Mutation_p.M72L|ARPP19_ENST00000567669.1_Missense_Mutation_p.M72L|ARPP19_ENST00000249822.4_Missense_Mutation_p.M72L|ARPP19_ENST00000561971.1_Missense_Mutation_p.M91L|ARPP19_ENST00000568196.1_Missense_Mutation_p.M56L|ARPP19_ENST00000563277.1_Missense_Mutation_p.M56L|ARPP19_ENST00000565288.1_5'UTR			P56211	ARP19_HUMAN	cAMP-regulated phosphoprotein, 19kDa	72					cell division|G2/M transition of mitotic cell cycle|mitosis|positive regulation of gluconeogenesis|positive regulation of glucose import	cytoplasm	potassium channel regulator activity|protein phosphatase 2A binding|protein phosphatase inhibitor activity|protein phosphatase type 2A regulator activity|receptor binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(1)	4						TTGTTCTTCATTTTTGCTTTA	0.408000													27	46					0	0	1	0	0
CUBN	8029	broad.mit.edu	37	10	16893433	16893433	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr10:16893433T>C	ENST00000377833.4	-	60	9529	c.9464A>G	c.(9463-9465)cAa>cGa	p.Q3155R		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	3155					cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	ACCACATCCTTGCTGAGGCCC	0.398000													11	54					0	0	1	0	0
KIAA0368	23392	broad.mit.edu	37	9	114133921	114133921	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr9:114133921C>A	ENST00000259335.4	-	44	5250	c.5251G>T	c.(5251-5253)Gga>Tga	p.G1751*	KIAA0368_ENST00000338205.5_Nonsense_Mutation_p.G1573*|KIAA0368_ENST00000374378.3_Nonsense_Mutation_p.G37*	NM_001080398.1	NP_001073867.1			KIAA0368											NS(2)|breast(3)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(23)|prostate(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	65						CACGTTCTTCCAGCCAGGCCT	0.448000													39	173					8.69298e-16	9.33046e-16	1	1	0
PHF14	9678	broad.mit.edu	37	7	11053504	11053504	+	Silent	SNP	T	T	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr7:11053504T>C	ENST00000403050.3	+	5	1628	c.1176T>C	c.(1174-1176)gaT>gaC	p.D392D	PHF14_ENST00000445996.2_Silent_p.D107D	NM_014660.3	NP_055475.2	O94880	PHF14_HUMAN	PHD finger protein 14	392							zinc ion binding	p.D392E(1)		NS(2)|breast(1)|endometrium(4)|kidney(5)|large_intestine(5)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	35				UCEC - Uterine corpus endometrioid carcinoma (126;0.205)		CTAATCAGGATGGAATTTTCA	0.398000													5	17					0	0	1	0	0
FGGY	55277	broad.mit.edu	37	1	60139745	60139745	+	Silent	SNP	C	C	G	rs114601020	by1000genomes	TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:60139745C>G	ENST00000371218.4	+	15	1708	c.1524C>G	c.(1522-1524)tcC>tcG	p.S508S	FGGY_ENST00000371210.1_Silent_p.S185S|FGGY_ENST00000303721.7_Silent_p.S484S|FGGY_ENST00000371212.1_Silent_p.S396S	NM_001113411.1	NP_001106882.1	Q96C11	FGGY_HUMAN	FGGY carbohydrate kinase domain containing	484					carbohydrate metabolic process|cell death|neuron homeostasis		kinase activity|phosphotransferase activity, alcohol group as acceptor			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	22	all_cancers(7;7.36e-05)					AGGTGGAGTCCGTTCTTGTGG	0.612000													3	4					0	0	1	0	0
CEP290	80184	broad.mit.edu	37	12	88477726	88477726	+	Silent	SNP	T	T	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr12:88477726T>C	ENST00000552810.1	-	36	5053	c.4710A>G	c.(4708-4710)caA>caG	p.Q1570Q	CEP290_ENST00000547691.2_Silent_p.Q630Q|CEP290_ENST00000309041.7_Silent_p.Q1572Q|CEP290_ENST00000397838.3_Silent_p.Q630Q	NM_025114.3	NP_079390.3	O15078	CE290_HUMAN	centrosomal protein 290kDa	1570					cilium assembly|eye photoreceptor cell development|G2/M transition of mitotic cell cycle|hindbrain development|otic vesicle formation|positive regulation of transcription, DNA-dependent|pronephros development|protein transport	cell surface|centrosome|cytosol|nucleus|photoreceptor connecting cilium	protein binding			breast(4)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(20)|liver(1)|lung(18)|ovary(5)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	73						CAATTTCTCTTTGCTCCTGTT	0.294000													4	6					0	0	1	0	0
ANKRD12	23253	broad.mit.edu	37	18	9255422	9255422	+	Silent	SNP	A	A	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr18:9255422A>G	ENST00000262126.4	+	9	2397	c.2157A>G	c.(2155-2157)acA>acG	p.T719T	ANKRD12_ENST00000383440.2_Silent_p.T696T|ANKRD12_ENST00000400020.3_Silent_p.T696T	NM_015208.4	NP_056023.3	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12							nucleus				NS(1)|breast(3)|central_nervous_system(2)|endometrium(8)|kidney(2)|large_intestine(20)|lung(18)|ovary(3)|pancreas(1)|prostate(4)|skin(1)|urinary_tract(2)	65						AATCCTTAACATTAGAAAAAA	0.294000													5	10					0	0	1	0	0
ACER2	340485	broad.mit.edu	37	9	19450618	19450618	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr9:19450618C>T	ENST00000340967.2	+	6	838	c.812C>T	c.(811-813)tCa>tTa	p.S271L		NM_001010887.2	NP_001010887.2	Q5QJU3	ACER2_HUMAN	alkaline ceramidase 2	271					ceramide metabolic process|negative regulation of cell adhesion mediated by integrin|negative regulation of cell-matrix adhesion|negative regulation of protein glycosylation in Golgi|positive regulation of cell proliferation|response to retinoic acid|sphingosine biosynthetic process	integral to Golgi membrane	ceramidase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|prostate(1)|skin(1)	13						AAGAAATCATCAGTCAAGATC	0.522000													26	158					0	0	1	0	0
LRIT2	340745	broad.mit.edu	37	10	85984284	85984284	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr10:85984284C>G	ENST00000372113.4	-	2	702	c.697G>C	c.(697-699)Ggc>Cgc	p.G233R	LRIT2_ENST00000538192.1_Missense_Mutation_p.G233R	NM_001017924.2	NP_001017924.1	A6NDA9	LRIT2_HUMAN	leucine-rich repeat, immunoglobulin-like and transmembrane domains 2	233	LRRCT.					integral to membrane		p.G233C(1)		central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(13)|ovary(3)|prostate(6)|urinary_tract(1)	32						GACAGAGGGCCCTGACATATC	0.532000													24	44					0	0	1	0	0
SKOR1	390598	broad.mit.edu	37	15	68118509	68118509	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr15:68118509G>A	ENST00000380035.2	+	2	401	c.343G>A	c.(343-345)Gag>Aag	p.E115K	SKOR1_ENST00000554240.1_Missense_Mutation_p.E76K|SKOR1_ENST00000341418.5_Missense_Mutation_p.E301K|SKOR1_ENST00000389002.1_Missense_Mutation_p.E106K|SKOR1_ENST00000554054.1_Missense_Mutation_p.E87K			P84550	SKOR1_HUMAN	SKI family transcriptional corepressor 1	115					negative regulation of BMP signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	cytoplasm|dendrite|neuronal cell body|nucleus	nucleotide binding|SMAD binding|transcription repressor activity			endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|lung(7)|urinary_tract(1)	23						CAGCTATAATGAGATCCACAA	0.632000													11	32					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179438608	179438608	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:179438608G>C	ENST00000589042.1	-	326	72475	c.72251C>G	c.(72250-72252)tCt>tGt	p.S24084C	TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.S15019C|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.S15144C|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.S15211C|TTN_ENST00000591111.1_Missense_Mutation_p.S22443C|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.S21516C|TTN-AS1_ENST00000586831.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	22443	Fibronectin type-III 75.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAGATTAGTAGAGAAATCTGC	0.423000													23	21					0	0	1	0	0
PLXNA1	5361	broad.mit.edu	37	3	126736395	126736395	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:126736395C>A	ENST00000393409.2	+	17	3404	c.3404C>A	c.(3403-3405)tCc>tAc	p.S1135Y	PLXNA1_ENST00000251772.4_Missense_Mutation_p.S1112Y	NM_032242.3	NP_115618.3	Q9UIW2	PLXA1_HUMAN	plexin A1	1135	IPT/TIG 3.				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			breast(3)|central_nervous_system(5)|endometrium(10)|kidney(5)|large_intestine(4)|lung(32)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	67				GBM - Glioblastoma multiforme(114;0.155)		AACGTGCGCTCCCTGCTTGTG	0.657000													51	180					1.38658e-30	1.50837e-30	1	1	0
TCHHL1	126637	broad.mit.edu	37	1	152058966	152058966	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:152058966C>T	ENST00000368806.1	-	3	1256	c.1192G>A	c.(1192-1194)Gag>Aag	p.E398K		NM_001008536.1	NP_001008536.1	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	398							calcium ion binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(1)|skin(7)|stomach(1)	60	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			CCATGGGCCTCAGGACCTCTC	0.473000													33	471					0	0	1	0	0
KCTD14	65987	broad.mit.edu	37	11	77734251	77734251	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr11:77734251C>T	ENST00000353172.5	-	1	89	c.45G>A	c.(43-45)acG>acA	p.T15T	KCTD14_ENST00000533144.1_Intron|RP11-7I15.4_ENST00000526730.1_RNA|NDUFC2-KCTD14_ENST00000528251.1_Intron|NDUFC2-KCTD14_ENST00000530054.1_Intron	NM_001203260.1|NM_001203262.1|NM_001282406.1|NM_023930.3	NP_001190189.1|NP_001190191.1|NP_001269335.1|NP_076419.2	Q9BQ13	KCD14_HUMAN	potassium channel tetramerization domain containing 14	15						voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(2)|kidney(1)|large_intestine(1)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	15	all_cancers(14;4.53e-19)|all_epithelial(13;1.73e-21)|Breast(9;2.71e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1e-24)			GGGTCTGGCTCGTCATCCTGC	0.706000													9	20					0	0	1	0	0
UBAP2L	9898	broad.mit.edu	37	1	154233401	154233401	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:154233401C>T	ENST00000428931.1	+	23	2779	c.2612C>T	c.(2611-2613)tCc>tTc	p.S871F	UBAP2L_ENST00000271877.7_Missense_Mutation_p.S882F|UBAP2L_ENST00000343815.6_Missense_Mutation_p.S871F|UBAP2L_ENST00000361546.2_Missense_Mutation_p.S871F	NM_014847.3	NP_055662.3	Q14157	UBP2L_HUMAN	ubiquitin associated protein 2-like	871					binding of sperm to zona pellucida		protein binding	p.S871Y(2)|p.S367Y(1)		NS(2)|breast(7)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(8)|lung(20)|ovary(1)|prostate(1)|urinary_tract(2)	50	all_lung(78;1.09e-30)|Lung NSC(65;1.66e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			GGGGATGCCTCCTCCCCAGCC	0.567000													17	82					0	0	1	0	0
LEO1	123169	broad.mit.edu	37	15	52258315	52258315	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr15:52258315C>A	ENST00000299601.5	-	2	505	c.445G>T	c.(445-447)Gat>Tat	p.D149Y	LEO1_ENST00000315141.5_Missense_Mutation_p.D149Y	NM_138792.2	NP_620147.1	Q8WVC0	LEO1_HUMAN	Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	149	Asp-rich.				histone H2B ubiquitination|histone monoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(5)|skin(1)	14				all cancers(107;0.00264)		TCACTTTTATCTTCTCTGCCC	0.418000													45	134					3.61183e-13	3.85528e-13	1	1	0
KLHL24	54800	broad.mit.edu	37	3	183396981	183396981	+	Silent	SNP	T	T	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:183396981T>C	ENST00000454652.2	+	9	2096	c.1710T>C	c.(1708-1710)agT>agC	p.S570S	KLHL24_ENST00000242810.6_Silent_p.S570S	NM_017644.3	NP_060114.2	Q6TFL4	KLH24_HUMAN	kelch-like family member 24							axon|cytoplasm|perikaryon				NS(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(10)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27	all_cancers(143;2.88e-10)|Ovarian(172;0.0303)		all cancers(12;1.43e-42)|Epithelial(37;1.73e-36)|OV - Ovarian serous cystadenocarcinoma(80;8.75e-22)			CTGCAACAAGTATCATCACAG	0.438000													24	88					0	0	1	0	0
ADGRG6	57211	broad.mit.edu	37	6	142711429	142711429	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr6:142711429G>C	ENST00000230173.6	+	7	1733	c.1257G>C	c.(1255-1257)caG>caC	p.Q419H	GPR126_ENST00000367609.3_Missense_Mutation_p.Q419H|GPR126_ENST00000367608.2_Missense_Mutation_p.Q391H|GPR126_ENST00000296932.8_Missense_Mutation_p.Q391H	NM_020455.5	NP_065188	Q86SQ4	GP126_HUMAN	G protein-coupled receptor 126	419					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			cervix(1)|endometrium(1)|kidney(3)|large_intestine(12)|lung(10)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	36	Breast(32;0.176)			OV - Ovarian serous cystadenocarcinoma(155;9.33e-06)|GBM - Glioblastoma multiforme(68;0.00121)		TAGTGATTCAGAACATCCTTC	0.318000													4	38					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237617837	237617837	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:237617837G>A	ENST00000366574.2	+	15	1756	c.1439G>A	c.(1438-1440)cGa>cAa	p.R480Q	RYR2_ENST00000542537.1_Missense_Mutation_p.R464Q|RYR2_ENST00000360064.6_Missense_Mutation_p.R478Q	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	480					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AACAGACTACGAGCCCTGAAG	0.443000													4	21					0	0	1	0	0
CNTRL	11064	broad.mit.edu	37	9	123919865	123919865	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr9:123919865G>A	ENST00000373855.1	+	28	4743	c.4483G>A	c.(4483-4485)Gat>Aat	p.D1495N	CNTRL_ENST00000373847.1_Missense_Mutation_p.D943N|CNTRL_ENST00000238341.5_Missense_Mutation_p.D1495N|CNTRL_ENST00000373845.2_3'UTR|CNTRL_ENST00000373850.1_Missense_Mutation_p.D943N			Q7Z7A1	CNTRL_HUMAN	centriolin	1495					cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding			haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(2)|ovary(4)|skin(3)	20						CGTCAAAGCTGATCAGCAGCT	0.393000													17	52					0	0	1	0	0
SDHAP1	255812	broad.mit.edu	37	3	195690254	195690254	+	RNA	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:195690254C>G	ENST00000427841.1	-	0	2241					NR_003264.2																						CAGCCTCATTCAAAGTTTTGT	0.408000													8	38					0	0	1	0	0
ADIPOQ	9370	broad.mit.edu	37	3	186572087	186572087	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:186572087T>C	ENST00000412955.2	+	3	470	c.329T>C	c.(328-330)gTa>gCa	p.V110A	ADIPOQ-AS1_ENST00000422718.1_RNA|ADIPOQ_ENST00000444204.2_Missense_Mutation_p.V110A|ADIPOQ_ENST00000320741.2_Missense_Mutation_p.V110A			Q15848	ADIPO_HUMAN	adiponectin, C1Q and collagen domain containing	110	C1q.				brown fat cell differentiation|cellular response to drug|cellular response to insulin stimulus|detection of oxidative stress|fatty acid beta-oxidation|generation of precursor metabolites and energy|glucose homeostasis|glucose metabolic process|low-density lipoprotein particle clearance|negative regulation of blood pressure|negative regulation of DNA biosynthetic process|negative regulation of ERK1 and ERK2 cascade|negative regulation of eukaryotic cell surface binding|negative regulation of fat cell differentiation|negative regulation of gluconeogenesis|negative regulation of granulocyte differentiation|negative regulation of heterotypic cell-cell adhesion|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of inflammatory response|negative regulation of intracellular protein transport|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|negative regulation of macrophage differentiation|negative regulation of MAP kinase activity|negative regulation of phagocytosis|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein autophosphorylation|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell proliferation|negative regulation of synaptic transmission|negative regulation of transcription, DNA-dependent|negative regulation of tumor necrosis factor production|negative regulation of tumor necrosis factor-mediated signaling pathway|positive regulation of cAMP-dependent protein kinase activity|positive regulation of cholesterol efflux|positive regulation of fatty acid metabolic process|positive regulation of glucose import|positive regulation of glycogen (starch) synthase activity|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 production|positive regulation of metanephric glomerular visceral epithelial cell development|positive regulation of monocyte chemotactic protein-1 production|positive regulation of myeloid cell apoptosis|positive regulation of protein kinase A signaling cascade|positive regulation of renal albumin absorption|protein homooligomerization|protein localization in plasma membrane|response to glucose stimulus|response to tumor necrosis factor	collagen|endoplasmic reticulum|extracellular space	cytokine activity|eukaryotic cell surface binding|hormone activity|protein homodimerization activity			breast(1)|endometrium(2)|large_intestine(4)|lung(6)|ovary(1)|skin(2)	16	all_cancers(143;1.2e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.47e-19)	GBM - Glioblastoma multiforme(93;0.0776)		GGTGCCTATGTATACCGCTCA	0.512000													43	71					0	0	1	0	0
AKAP8L	26993	broad.mit.edu	37	19	15507984	15507984	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:15507984T>C	ENST00000397410.5	-	12	1643	c.1513A>G	c.(1513-1515)Atg>Gtg	p.M505V	AKAP8L_ENST00000595465.2_Missense_Mutation_p.M444V	NM_014371.2	NP_055186.2	Q9ULX6	AKP8L_HUMAN	A kinase (PRKA) anchor protein 8-like							cytoplasm|nuclear matrix	DEAD/H-box RNA helicase binding|DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|kidney(2)|lung(1)|ovary(1)|prostate(1)|urinary_tract(1)	11						TTGTGATCCATGGTCTTCAGA	0.552000													24	122					0	0	1	0	0
HS6ST2	90161	broad.mit.edu	37	X	131762712	131762712	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chrX:131762712T>A	ENST00000370836.2	-	4	1772	c.1357A>T	c.(1357-1359)Att>Ttt	p.I453F	HS6ST2_ENST00000370833.2_Missense_Mutation_p.I347F|HS6ST2_ENST00000406696.3_Missense_Mutation_p.I179F|HS6ST2_ENST00000521489.1_Missense_Mutation_p.I493F	NM_147175.3	NP_671704.3	Q96MM7	H6ST2_HUMAN	heparan sulfate 6-O-sulfotransferase 2	453						integral to membrane	sulfotransferase activity			central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(2)	9	Acute lymphoblastic leukemia(192;0.000127)					AATGGCGAAATAAAGTTCATG	0.418000													60	14					0	0	1	0	0
KIF14	9928	broad.mit.edu	37	1	200574454	200574454	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:200574454G>T	ENST00000367350.4	-	8	2141	c.1703C>A	c.(1702-1704)tCc>tAc	p.S568Y		NM_014875.2	NP_055690.1	Q15058	KIF14_HUMAN	kinesin family member 14	568	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			NS(1)|breast(5)|central_nervous_system(2)|endometrium(8)|kidney(8)|large_intestine(15)|lung(13)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	61						ATGAGATCGGGAACTTTTATC	0.398000													8	53					0.0477658	0.0480143	1	1	0
HFE2	148738	broad.mit.edu	37	1	145415418	145415418	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:145415418C>T	ENST00000336751.5	+	3	475	c.237C>T	c.(235-237)ctC>ctT	p.L79L	HFE2_ENST00000357836.5_5'UTR|HFE2_ENST00000497365.1_Intron|HFE2_ENST00000475797.1_Intron	NM_213653.3	NP_998818.1	Q6ZVN8	RGMC_HUMAN	hemochromatosis type 2 (juvenile)	79					axon guidance	anchored to membrane				central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)	14	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CTGGCGGCCTCTGTCGAGCCC	0.672000													6	144					0	0	1	0	0
STIL	6491	broad.mit.edu	37	1	47746268	47746268	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:47746268T>C	ENST00000360380.3	-	13	2225	c.1862A>G	c.(1861-1863)cAa>cGa	p.Q621R	STIL_ENST00000371877.3_Missense_Mutation_p.Q621R|STIL_ENST00000396221.2_Missense_Mutation_p.Q621R|STIL_ENST00000337817.5_Missense_Mutation_p.Q621R|STIL_ENST00000243182.6_Missense_Mutation_p.Q621R	NM_001282936.1	NP_001269865.1	Q15468	STIL_HUMAN	SCL/TAL1 interrupting locus	621	PIN1-binding (By similarity).				cell proliferation|multicellular organismal development	centrosome|cytosol				central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(14)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	36		Acute lymphoblastic leukemia(5;0.00116)|all_hematologic(5;0.00444)				GTTTGCTCCTTGCCAAGAATT	0.438000													45	94					0	0	1	0	0
NFXL1	152518	broad.mit.edu	37	4	47900853	47900853	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr4:47900853C>G	ENST00000507489.1	-	8	1186	c.1010G>C	c.(1009-1011)aGa>aCa	p.R337T	NFXL1_ENST00000329043.3_Missense_Mutation_p.R337T|NFXL1_ENST00000381538.3_Missense_Mutation_p.R337T	NM_001278624.1	NP_001265553.1	Q6ZNB6	NFXL1_HUMAN	nuclear transcription factor, X-box binding-like 1	337						integral to membrane|nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|skin(4)	27						TCTACTAACTCTTGGACAAGG	0.353000													11	43					0	0	1	0	0
ERBB2	2064	broad.mit.edu	37	17	37868208	37868208	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr17:37868208C>T	ENST00000406381.2	+	10	1349	c.839C>T	c.(838-840)tCc>tTc	p.S280F	ERBB2_ENST00000445658.2_Missense_Mutation_p.S34F|ERBB2_ENST00000540147.1_Missense_Mutation_p.S280F|ERBB2_ENST00000540042.1_Missense_Mutation_p.S280F|ERBB2_ENST00000584601.1_Missense_Mutation_p.S280F|ERBB2_ENST00000584450.1_Missense_Mutation_p.S310F|ERBB2_ENST00000578199.1_Missense_Mutation_p.S280F|ERBB2_ENST00000269571.5_Missense_Mutation_p.S310F|ERBB2_ENST00000541774.1_Missense_Mutation_p.S295F	NM_001005862.1	NP_001005862.1	P04626	ERBB2_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2	310					cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.S310F(6)|p.S310Y(1)		NS(1)|breast(16)|central_nervous_system(17)|endometrium(6)|haematopoietic_and_lymphoid_tissue(8)|kidney(4)|large_intestine(16)|liver(3)|lung(125)|ovary(18)|pancreas(1)|prostate(4)|skin(1)|stomach(14)|upper_aerodigestive_tract(9)|urinary_tract(4)	247	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	GACGTGGGATCCTGCACCCTC	0.582000		1	"""A, Mis, O"""		"""breast, ovarian, other tumour types, NSCLC, gastric"""					TCGA GBM(5;<1E-08)			51	217					0	0	1	0	0
NSMCE1	197370	broad.mit.edu	37	16	27245536	27245536	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr16:27245536C>G	ENST00000361439.4	-	4	408	c.309G>C	c.(307-309)gaG>gaC	p.E103D		NM_145080.3	NP_659547.2	Q8WV22	NSE1_HUMAN	non-SMC element 1 homolog (S. cerevisiae)	103					DNA recombination|DNA repair|intracellular signal transduction	nucleus	zinc ion binding			endometrium(2)|large_intestine(2)|lung(3)	7						CCAGTTCATTCTCTGCAAAAT	0.438000													13	105					0	0	1	0	0
PACSIN3	29763	broad.mit.edu	37	11	47201882	47201882	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr11:47201882G>A	ENST00000539589.1	-	6	800	c.458C>T	c.(457-459)tCc>tTc	p.S153F	PACSIN3_ENST00000298838.6_Missense_Mutation_p.S153F	NM_001184975.1	NP_001171904.1	Q9UKS6	PACN3_HUMAN	protein kinase C and casein kinase substrate in neurons 3	153					endocytosis|negative regulation of endocytosis|positive regulation of membrane protein ectodomain proteolysis	cytoplasm|plasma membrane	cytoskeletal protein binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)	11						GCTTTTCTTGGAAGCCTCAAC	0.617000											OREG0020952	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	37					0	0	1	0	0
PON3	5446	broad.mit.edu	37	7	94993301	94993301	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr7:94993301A>T	ENST00000265627.5	-	6	579	c.569T>A	c.(568-570)cTg>cAg	p.L190Q	PON3_ENST00000451904.1_Missense_Mutation_p.L190Q|PON3_ENST00000427422.1_Missense_Mutation_p.L190Q|PON1_ENST00000542556.1_Intron	NM_000940.2	NP_000931.1			paraoxonase 3											breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(2)|skin(2)	24	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0151)			AAAAAATGACAGGAGGGAGTT	0.433000													38	68					0	0	1	0	0
PALD1	27143	broad.mit.edu	37	10	72324257	72324257	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr10:72324257C>T	ENST00000263563.6	+	19	2668	c.2400C>T	c.(2398-2400)ttC>ttT	p.F800F		NM_014431.2	NP_055246.2			phosphatase domain containing, paladin 1																		AGAGGCCCTTCAGCACCTGGA	0.637000													32	57					0	0	1	0	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274416	39274416	+	Missense_Mutation	SNP	C	C	T	rs408579	by1000genomes	TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr17:39274416C>T	ENST00000391413.2	-	1	190	c.152G>A	c.(151-153)aGg>aAg	p.R51K		NM_033059.3	NP_149048.2	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	51	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].		Missing (in allele KAP4.14).			keratin filament		p.R51K(1)		endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|lung(8)|prostate(5)|skin(1)	33		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			GCACTGGGGCCTGCAGCAGCT	0.672000													4	61					0	0	1	0	0
QPCT	25797	broad.mit.edu	37	2	37586827	37586827	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:37586827C>T	ENST00000338415.3	+	3	530	c.372C>T	c.(370-372)atC>atT	p.I124I	QPCT_ENST00000537448.1_Silent_p.I75I	NM_012413.3	NP_036545.1	Q16769	QPCT_HUMAN	glutaminyl-peptide cyclotransferase	124					peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase|proteolysis	extracellular region	acyltransferase activity|glutaminyl-peptide cyclotransferase activity|peptidase activity|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(3)|prostate(1)|stomach(2)	17		Ovarian(717;0.051)|all_hematologic(82;0.21)				CAAATATCATCAGCACCCTCA	0.483000													23	90					0	0	1	0	0
HDAC2	3066	broad.mit.edu	37	6	114265514	114265514	+	Silent	SNP	A	A	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr6:114265514A>G	ENST00000519065.1	-	11	1528	c.1152T>C	c.(1150-1152)gcT>gcC	p.A384A	HDAC2_ENST00000519108.1_Silent_p.A354A|HDAC2_ENST00000398283.2_Silent_p.A478A|HDAC2_ENST00000368632.2_Silent_p.A354A			Q92769	HDAC2_HUMAN	histone deacetylase 2	384					blood coagulation|dendrite development|embryonic digit morphogenesis|epidermal cell differentiation|eyelid development in camera-type eye|fungiform papilla formation|hair follicle placode formation|maintenance of chromatin silencing|negative regulation of apoptosis|negative regulation of cell cycle|negative regulation of neuron projection development|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|odontogenesis of dentine-containing tooth|positive regulation of cell proliferation|positive regulation of proteolysis|positive regulation of receptor biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|ESC/E(Z) complex|NuRD complex|Sin3 complex	chromatin binding|enzyme binding|histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|sequence-specific DNA binding|transcription factor binding			biliary_tract(1)|central_nervous_system(5)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(11)|ovary(1)|prostate(1)|skin(2)	27		all_cancers(87;0.000629)|all_epithelial(87;0.00274)|Colorectal(196;0.0317)|all_lung(197;0.24)		all cancers(137;0.00318)|OV - Ovarian serous cystadenocarcinoma(136;0.00569)|Epithelial(106;0.0112)|GBM - Glioblastoma multiforme(226;0.0832)	Vorinostat(DB02546)	CTTCTGGAATAGCTTGCATCT	0.358000													27	35					0	0	1	0	0
POU2F2	5452	broad.mit.edu	37	19	42600013	42600013	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:42600013G>A	ENST00000389341.5	-	9	750	c.684C>T	c.(682-684)ttC>ttT	p.F228F	POU2F2_ENST00000529067.1_Silent_p.F228F|POU2F2_ENST00000560558.1_Silent_p.F189F|POU2F2_ENST00000529952.1_Silent_p.F244F|POU2F2_ENST00000342301.4_Silent_p.F244F|POU2F2_ENST00000526816.2_Silent_p.F244F|POU2F2_ENST00000560398.1_Silent_p.F250F|POU2F2_ENST00000533720.1_Silent_p.F228F	NM_001207025.2|NM_001247994.1|NM_002698.4	NP_001193954.1|NP_001234923.1|NP_002689.1	P09086	PO2F2_HUMAN	POU class 2 homeobox 2	244	POU-specific.				humoral immune response|transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(5)|lung(4)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Prostate(69;0.059)				TGAGGGCCTCGAAGCGGGAAA	0.622000													24	74					0	0	1	0	0
DPP9	91039	broad.mit.edu	37	19	4700228	4700228	+	Splice_Site	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:4700228C>T	ENST00000262960.9	-	10	1351	c.1074G>A	c.(1072-1074)aaG>aaA	p.K358K	DPP9_ENST00000597849.1_Splice_Site_p.K358K|DPP9_ENST00000598800.1_Splice_Site_p.K329K|DPP9_ENST00000594671.1_Splice_Site_p.K329K	NM_139159.4	NP_631898.3	Q86TI2	DPP9_HUMAN	dipeptidyl-peptidase 9	329					proteolysis	cytosol|membrane	aminopeptidase activity|serine-type peptidase activity			cervix(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00884)		GCCCCCTTACCTTGCCCTGGC	0.572000													12	20					0	0	1	0	0
ALDH1B1	219	broad.mit.edu	37	9	38396802	38396802	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr9:38396802G>C	ENST00000377698.3	+	2	1210	c.1057G>C	c.(1057-1059)Gag>Cag	p.E353Q		NM_000692.4	NP_000683.3	P30837	AL1B1_HUMAN	aldehyde dehydrogenase 1 family, member B1	353					carbohydrate metabolic process	mitochondrial matrix|nucleus	aldehyde dehydrogenase (NAD) activity			NS(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(1)|stomach(2)|urinary_tract(2)	32				GBM - Glioblastoma multiforme(29;0.043)|Lung(182;0.115)	NADH(DB00157)	GAACCCCTTTGAGCTGGACAC	0.557000													25	62					0	0	1	0	0
PKD1	5310	broad.mit.edu	37	16	2152630	2152630	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr16:2152630T>C	ENST00000262304.4	-	25	9161	c.8953A>G	c.(8953-8955)Aga>Gga	p.R2985G	PKD1_ENST00000423118.1_Missense_Mutation_p.R2985G	NM_001009944.2	NP_001009944	P98161	PKD1_HUMAN	polycystic kidney disease 1 (autosomal dominant)	2985			R -> G (in ADPKD1).		calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|lung(34)|prostate(4)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						GCTGGGTCTCTGCTCCTGGGC	0.652000													10	27					0	0	1	0	0
BMP2	650	broad.mit.edu	37	20	6750813	6750813	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr20:6750813C>T	ENST00000378827.4	+	2	1259	c.40C>T	c.(40-42)Ccc>Tcc	p.P14S		NM_001200.2	NP_001191.1	P12643	BMP2_HUMAN	bone morphogenetic protein 2	14					BMP signaling pathway involved in heart induction|bone mineralization involved in bone maturation|cardiac cell differentiation|cardiac epithelial to mesenchymal transition|cartilage development|growth|negative regulation of cell cycle|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|pathway-restricted SMAD protein phosphorylation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cartilage development|positive regulation of endothelial cell proliferation|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of phosphatase activity|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	activin receptor activity, type II|BMP receptor binding|cytokine activity|growth factor activity|phosphatase activator activity|protein heterodimerization activity|SMAD binding|transforming growth factor beta receptor binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)	13					Simvastatin(DB00641)	GTTGCTGCTTCCCCAGGTCCT	0.716000													5	15					0	0	1	0	0
SHROOM3	57619	broad.mit.edu	37	4	77680748	77680748	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr4:77680748A>G	ENST00000296043.6	+	9	6202	c.5249A>G	c.(5248-5250)tAc>tGc	p.Y1750C	RP11-359D14.3_ENST00000449007.1_RNA	NM_020859.3	NP_065910.3	Q8TF72	SHRM3_HUMAN	shroom family member 3	1750	ASD2.				apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(29)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	60			Lung(101;0.0903)			CCTGCCTACTACAGTGTGTCT	0.478000													14	40					0	0	1	0	0
UQCRC1	7384	broad.mit.edu	37	3	48646698	48646698	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:48646698G>A	ENST00000203407.5	-	2	523	c.107C>T	c.(106-108)gCa>gTa	p.A36V		NM_003365.2	NP_003356.2	P31930	QCR1_HUMAN	ubiquinol-cytochrome c reductase core protein I	36					aerobic respiration|proteolysis		metalloendopeptidase activity|ubiquinol-cytochrome-c reductase activity|zinc ion binding			breast(1)|endometrium(2)|large_intestine(2)|lung(2)|ovary(2)|pancreas(1)|prostate(4)|skin(1)|urinary_tract(1)	16				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)	Atovaquone(DB01117)	AGCGAAGGTTGCCGTACTCCG	0.677000													12	28					0	0	1	0	0
AIPL1	23746	broad.mit.edu	37	17	6338333	6338333	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr17:6338333G>A	ENST00000381129.3	-	1	172	c.92C>T	c.(91-93)tCc>tTc	p.S31F	AIPL1_ENST00000570466.1_Missense_Mutation_p.S31F|AIPL1_ENST00000576776.1_Missense_Mutation_p.S31F|AIPL1_ENST00000575265.1_Missense_Mutation_p.S31F|AIPL1_ENST00000576307.1_Missense_Mutation_p.S31F|AIPL1_ENST00000571740.1_Missense_Mutation_p.S31F|AIPL1_ENST00000574506.1_Missense_Mutation_p.S31F|AIPL1_ENST00000250087.5_Missense_Mutation_p.S31F	NM_001033055.1|NM_014336.3	NP_001028227.1|NP_055151.3	Q9NZN9	AIPL1_HUMAN	aryl hydrocarbon receptor interacting protein-like 1	31					protein farnesylation|protein folding|visual perception	cytoplasm|nucleus	farnesylated protein binding|unfolded protein binding			NS(1)|kidney(1)|large_intestine(2)|liver(1)|lung(5)|ovary(1)|skin(1)	12				COAD - Colon adenocarcinoma(228;0.141)		ACTCACTCGGGATCCGGTGAT	0.607000													15	32					0	0	1	0	0
MAP1A	4130	broad.mit.edu	37	15	43815555	43815555	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr15:43815555G>A	ENST00000382031.1	+	5	2629	c.2598G>A	c.(2596-2598)caG>caA	p.Q866Q	MAP1A_ENST00000300231.5_Silent_p.Q628Q|MAP1A_ENST00000399453.1_Silent_p.Q628Q			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	628						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	AAAAGAAGCAGAGGGAAGCAG	0.502000													6	10					0	0	1	0	0
SEPHS1	22929	broad.mit.edu	37	10	13361306	13361306	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr10:13361306C>T	ENST00000327347.5	-	9	1390	c.1015G>A	c.(1015-1017)Gag>Aag	p.E339K	SEPHS1_ENST00000378614.4_Missense_Mutation_p.E268K|SEPHS1_ENST00000537130.1_Missense_Mutation_p.E272K|SEPHS1_ENST00000545675.1_3'UTR	NM_001195602.1|NM_012247.4	NP_001182531.1|NP_036379.2	P49903	SPS1_HUMAN	selenophosphate synthetase 1	339					protein modification process		ATP binding|GTP binding|selenide, water dikinase activity			cervix(1)|endometrium(3)|large_intestine(3)|lung(6)|prostate(1)|skin(1)|stomach(1)	16						GACTTTATCTCTGCACAGAAC	0.483000													94	329					0	0	1	0	0
PIGZ	80235	broad.mit.edu	37	3	196674502	196674502	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:196674502G>A	ENST00000412723.1	-	3	1412	c.1266C>T	c.(1264-1266)ctC>ctT	p.L422L		NM_025163.2	NP_079439.2	Q86VD9	PIGZ_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class Z	422					GPI anchor biosynthetic process	integral to membrane|intrinsic to endoplasmic reticulum membrane	alpha-1,2-mannosyltransferase activity			breast(1)|endometrium(1)|lung(7)|ovary(3)|prostate(1)|urinary_tract(1)	14	all_cancers(143;1.05e-08)|Ovarian(172;0.0634)|Breast(254;0.0838)		Epithelial(36;4.29e-24)|all cancers(36;2.79e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.03e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00603)		GGAGGGCACCGAGGGCGTTGA	0.647000													11	34					0	0	1	0	0
TLR8	51311	broad.mit.edu	37	X	12938348	12938348	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chrX:12938348T>C	ENST00000218032.6	+	2	1276	c.1189T>C	c.(1189-1191)Tcg>Ccg	p.S397P	TLR8_ENST00000311912.5_Missense_Mutation_p.S415P	NM_138636.4	NP_619542.1	Q9NR97	TLR8_HUMAN	toll-like receptor 8	397					cellular response to mechanical stimulus|defense response to virus|I-kappaB kinase/NF-kappaB cascade|immunoglobulin mediated immune response|inflammatory response|innate immune response|positive regulation of innate immune response|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process	endosome membrane	DNA binding|double-stranded RNA binding|single-stranded RNA binding|transmembrane receptor activity			breast(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(21)|ovary(4)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	50						TCCAAACTTATCGACTATCAA	0.353000													30	43					0	0	1	0	0
FCHSD2	9873	broad.mit.edu	37	11	72553845	72553845	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr11:72553845C>T	ENST00000409314.1	-	18	1987	c.1819G>A	c.(1819-1821)Gat>Aat	p.D607N	FCHSD2_ENST00000409263.1_Intron|ATG16L2_ENST00000534905.1_3'UTR|FCHSD2_ENST00000409418.4_Missense_Mutation_p.D583N|FCHSD2_ENST00000458644.2_Missense_Mutation_p.D447N|FCHSD2_ENST00000311172.7_Missense_Mutation_p.D527N			O94868	FCSD2_HUMAN	FCH and double SH3 domains 2	583	SH3 2.						protein binding			endometrium(2)|large_intestine(11)|lung(5)|ovary(2)|prostate(1)|skin(1)	22			BRCA - Breast invasive adenocarcinoma(5;3.3e-05)			AACTCATCATCTGTCTGGCCC	0.398000													12	27					0	0	1	0	0
CHD9	80205	broad.mit.edu	37	16	53337721	53337721	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr16:53337721C>G	ENST00000566029.1	+	31	6012	c.5803C>G	c.(5803-5805)Cgg>Ggg	p.R1935G	CHD9_ENST00000447540.1_Missense_Mutation_p.R1935G|CHD9_ENST00000398510.3_Missense_Mutation_p.R1935G|CHD9_ENST00000564845.1_Missense_Mutation_p.R1935G			Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	1935					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(32)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	78		all_cancers(37;0.0212)				AAGGAAAGTACGGGAACAGGC	0.438000													22	13					0	0	1	0	0
ATP13A4	84239	broad.mit.edu	37	3	193175244	193175244	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:193175244A>T	ENST00000342695.4	-	15	2007	c.1685T>A	c.(1684-1686)tTt>tAt	p.F562Y	ATP13A4_ENST00000392443.3_Missense_Mutation_p.F543Y	NM_032279.2	NP_115655.2	Q4VNC1	AT134_HUMAN	ATPase type 13A4	562					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(27)|ovary(2)|prostate(3)|skin(11)|upper_aerodigestive_tract(2)	71	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		GTCCCCAGAAAAAGCCATTTC	0.473000													57	77					0	0	1	0	0
WNK1	65125	broad.mit.edu	37	12	994563	994563	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr12:994563G>C	ENST00000537687.1	+	19	6016	c.5373G>C	c.(5371-5373)aaG>aaC	p.K1791N	WNK1_ENST00000535572.1_Missense_Mutation_p.K1284N|WNK1_ENST00000315939.6_Missense_Mutation_p.K1531N|WNK1_ENST00000530271.2_Missense_Mutation_p.K2029N|WNK1_ENST00000340908.4_Missense_Mutation_p.K1124N	NM_001184985.1|NM_213655.4	NP_001171914.1|NP_998820.3	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	1531					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			breast(7)|central_nervous_system(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(43)|ovary(6)|prostate(3)|skin(7)|stomach(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	104	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			CACTAGATAAGACATCTCATA	0.478000													82	296					0	0	1	0	0
RARG	5916	broad.mit.edu	37	12	53607463	53607463	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr12:53607463A>G	ENST00000425354.2	-	8	1322	c.835T>C	c.(835-837)Tac>Cac	p.Y279H	RARG_ENST00000543726.1_Missense_Mutation_p.Y257H|RARG_ENST00000543762.1_5'UTR|RARG_ENST00000327550.3_Missense_Mutation_p.Y207H|RARG_ENST00000338561.5_Missense_Mutation_p.Y268H|RARG_ENST00000394426.1_Missense_Mutation_p.Y279H	NM_000966.5	NP_000957.1	P13631	RARG_HUMAN	retinoic acid receptor, gamma	279	Ligand-binding.				canonical Wnt receptor signaling pathway|embryonic eye morphogenesis|embryonic hindlimb morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|regulation of cell size|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid	integral to membrane|transcription factor complex	retinoic acid receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(6)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	TCTGGGGTGTACCTTGTGCAG	0.592000											OREG0021862	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	45					0	0	1	0	0
MARC1	64757	broad.mit.edu	37	1	220964944	220964944	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:220964944C>T	ENST00000366910.5	+	2	573	c.387C>T	c.(385-387)gcC>gcT	p.A129A		NM_022746.3	NP_073583.3	Q5VT66	MOSC1_HUMAN	mitochondrial amidoxime reducing component 1	129							molybdenum ion binding|oxidoreductase activity|pyridoxal phosphate binding										TCAGTGCAGCCTACACAAAGG	0.532000													8	51					0	0	1	0	0
PCDHB5	26167	broad.mit.edu	37	5	140516636	140516636	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr5:140516636G>A	ENST00000231134.5	+	1	1837	c.1620G>A	c.(1618-1620)ctG>ctA	p.L540L		NM_015669.2	NP_056484.1	Q9Y5E4	PCDB5_HUMAN		540	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|kidney(1)|large_intestine(18)|lung(25)|ovary(3)|prostate(6)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	81			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCCCGGCGCTGAGCAGCGAGG	0.692000													23	44					0	0	1	0	0
IMPG2	50939	broad.mit.edu	37	3	101038625	101038625	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:101038625G>C	ENST00000193391.7	-	2	324	c.137C>G	c.(136-138)tCt>tGt	p.S46C		NM_016247.3	NP_057331.2	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	46					visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			NS(1)|breast(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(14)|lung(32)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	64						CAGGAGAAAAGAAACTGCACT	0.413000													20	85					0	0	1	0	0
ARHGAP30	257106	broad.mit.edu	37	1	161017554	161017554	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:161017554G>T	ENST00000368013.3	-	12	3577	c.3257C>A	c.(3256-3258)tCa>tAa	p.S1086*	ARHGAP30_ENST00000368015.1_Nonsense_Mutation_p.S909*|ARHGAP30_ENST00000368016.3_Nonsense_Mutation_p.S875*	NM_001025598.1|NM_181720.2	NP_001020769.1|NP_859071.2	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30	1086					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(2)|cervix(3)|endometrium(4)|kidney(2)|large_intestine(4)|lung(6)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			AAATGCATATGACCTGCGCTG	0.557000													23	574					1.66031e-10	1.75285e-10	1	1	0
KCNA6	3742	broad.mit.edu	37	12	4919742	4919742	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr12:4919742G>A	ENST00000433855.1	+	1	1401	c.535G>A	c.(535-537)Gtc>Atc	p.V179I	KCNA6_ENST00000280684.3_Missense_Mutation_p.V179I	NM_002235.3	NP_002226.1	P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 6	179						voltage-gated potassium channel complex	voltage-gated potassium channel activity	p.V179I(1)		NS(1)|breast(3)|endometrium(5)|large_intestine(6)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(5)	49						CATCGCCATCGTCTCCGTGTT	0.592000										HNSCC(72;0.22)			16	42					0	0	1	0	0
ATG2B	55102	broad.mit.edu	37	14	96797941	96797941	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr14:96797941G>A	ENST00000359933.4	-	11	2395	c.1502C>T	c.(1501-1503)tCa>tTa	p.S501L		NM_018036.5	NP_060506	Q96BY7	ATG2B_HUMAN	autophagy related 2B	501										breast(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(11)|liver(1)|lung(26)|ovary(1)|prostate(1)|skin(1)|urinary_tract(7)	64		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		TTCAGGCCTTGATTCATCCAC	0.313000													19	12					0	0	1	0	0
CHD6	84181	broad.mit.edu	37	20	40112112	40112112	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr20:40112112C>T	ENST00000373233.3	-	16	2482	c.2305G>A	c.(2305-2307)Gat>Aat	p.D769N	CHD6_ENST00000309279.7_Intron	NM_032221.3	NP_115597.3	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	769					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(24)|lung(53)|ovary(8)|prostate(5)|skin(8)|stomach(1)|urinary_tract(9)	129		Myeloproliferative disorder(115;0.00425)				TCAGGGGCATCAGGGCTGTGG	0.448000													15	20					0	0	1	0	0
AAGAB	79719	broad.mit.edu	37	15	67529060	67529060	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr15:67529060T>C	ENST00000261880.5	-	2	276	c.172A>G	c.(172-174)Atc>Gtc	p.I58V	AAGAB_ENST00000542650.1_5'UTR|AAGAB_ENST00000561452.1_5'UTR	NM_001271885.1|NM_001271886.1|NM_024666.3	NP_001258814.1|NP_001258815.1|NP_078942.3	Q6PD74	AAGAB_HUMAN	alpha- and gamma-adaptin binding protein	58					protein transport	cytoplasm				breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|prostate(1)	9						CATAGATTGATGTCTGCTGAA	0.378000													11	20					0	0	1	0	0
APOBEC4	403314	broad.mit.edu	37	1	183617405	183617405	+	Missense_Mutation	SNP	C	C	T	rs139605657		TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:183617405C>T	ENST00000308641.4	-	2	783	c.512G>A	c.(511-513)cGc>cAc	p.R171H	APOBEC4_ENST00000481562.1_Intron|RGL1_ENST00000536277.1_Intron|RGL1_ENST00000304685.4_Intron	NM_203454.2	NP_982279.1	Q8WW27	ABEC4_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)	171					mRNA processing		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|zinc ion binding			NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(4)|lung(6)|skin(1)	21						GAGAGCTTCGCGGTTCCATGC	0.463000													14	56					0	0	1	0	0
MRPL53	116540	broad.mit.edu	37	2	74699247	74699247	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:74699247C>T	ENST00000258105.7	-	3	999	c.338G>A	c.(337-339)tGa>tAa	p.*113*	MRPL53_ENST00000409710.1_3'UTR	NM_053050.4	NP_444278.1	Q96EL3	RM53_HUMAN	mitochondrial ribosomal protein L53	0						mitochondrion|ribosome		p.*113L(1)		central_nervous_system(1)|large_intestine(2)|lung(1)|urinary_tract(1)	5						TTGGCGCTGTCAGCGACCAGT	0.547000													27	49					0	0	1	0	0
RUSC1	23623	broad.mit.edu	37	1	155292282	155292282	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:155292282G>A	ENST00000368352.5	+	2	869	c.718G>A	c.(718-720)Gag>Aag	p.E240K	RUSC1-AS1_ENST00000450199.1_RNA|RUSC1_ENST00000368354.3_Missense_Mutation_p.E240K|RUSC1-AS1_ENST00000443642.1_RNA	NM_001105203.1	NP_001098673.1	Q9BVN2	RUSC1_HUMAN	RUN and SH3 domain containing 1	240						cytoplasm|nucleolus	SH3/SH2 adaptor activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(2)|liver(2)|lung(7)|ovary(2)|skin(1)|urinary_tract(1)	21	Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;1.55e-10)|all cancers(21;4.15e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000549)|LUSC - Lung squamous cell carcinoma(543;0.127)			AATTGACACAGAGAAAACTAA	0.418000													11	92					0	0	1	0	0
TTPA	7274	broad.mit.edu	37	8	63976765	63976765	+	Splice_Site	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr8:63976765C>G	ENST00000260116.4	-	4	694	c.663G>C	c.(661-663)cgG>cgC	p.R221R	TTPA_ENST00000521138.1_Intron	NM_000370.3	NP_000361.1	P49638	TTPA_HUMAN	tocopherol (alpha) transfer protein	221	CRAL-TRIO.		R -> W (in AVED; dbSNP:rs35916840).		lipid metabolic process		transporter activity|vitamin E binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(8)	15	Breast(64;0.0716)	all_cancers(86;0.145)|Lung NSC(129;0.0324)|all_lung(136;0.0593)|all_epithelial(80;0.123)			Vitamin E(DB00163)	TTTTACTCACCCGTTCCTTAA	0.368000													9	17					0	0	1	0	0
ASTN2	23245	broad.mit.edu	37	9	120176811	120176811	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr9:120176811C>T	ENST00000313400.4	-	1	506	c.406G>A	c.(406-408)Gac>Aac	p.D136N	ASTN2_ENST00000361477.3_5'UTR|ASTN2_ENST00000373996.3_Missense_Mutation_p.D136N|ASTN2_ENST00000361209.2_Missense_Mutation_p.D136N			O75129	ASTN2_HUMAN	astrotactin 2	136						integral to membrane				breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(21)|lung(45)|ovary(4)|pancreas(2)|prostate(2)|skin(9)|stomach(1)|urinary_tract(1)	102						TTGTCCAGGTCGTCCTGCACC	0.706000													4	31					0	0	1	0	0
GSTO2	119391	broad.mit.edu	37	10	106037865	106037865	+	Silent	SNP	A	A	G	rs141797686		TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr10:106037865A>G	ENST00000369707.2	+	2	387	c.273A>G	c.(271-273)ctA>ctG	p.L91L	GSTO2_ENST00000429569.2_Silent_p.L91L|GSTO2_ENST00000477078.2_3'UTR|GSTO2_ENST00000401888.2_Silent_p.L119L|GSTO2_ENST00000450629.2_Silent_p.L119L|GSTO2_ENST00000338595.2_Silent_p.L119L	NM_001191014.1	NP_001177943.1	Q9H4Y5	GSTO2_HUMAN	glutathione S-transferase omega 2		GST N-terminal.				water-soluble vitamin metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			NS(1)|breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(2)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	11		Colorectal(252;0.178)		Epithelial(162;1.14e-09)|all cancers(201;3.89e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0155)	Glutathione(DB00143)	TATTGGAGCTATTTTGTAAGG	0.378000													11	28					0	0	1	0	0
NR1I3	9970	broad.mit.edu	37	1	161203049	161203049	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:161203049C>T	ENST00000367983.4	-	4	612	c.318G>A	c.(316-318)ctG>ctA	p.L106L	NR1I3_ENST00000367982.4_Silent_p.L106L|NR1I3_ENST00000367984.4_Silent_p.L106L|NR1I3_ENST00000511944.1_Intron|NR1I3_ENST00000512372.1_Silent_p.L77L|NR1I3_ENST00000367979.2_Silent_p.L106L|NR1I3_ENST00000437437.2_Silent_p.L77L|NR1I3_ENST00000367985.3_Silent_p.L106L|NR1I3_ENST00000505005.1_Silent_p.L106L|NR1I3_ENST00000506209.1_Silent_p.L77L|NR1I3_ENST00000508740.1_Silent_p.L77L|NR1I3_ENST00000367980.2_Silent_p.L106L|NR1I3_ENST00000511748.1_Intron|NR1I3_ENST00000428574.2_Silent_p.L106L|NR1I3_ENST00000504010.1_Silent_p.L77L|NR1I3_ENST00000442691.2_Silent_p.L106L|NR1I3_ENST00000508387.1_Intron|NR1I3_ENST00000412844.2_Silent_p.L77L|NR1I3_ENST00000515452.1_Silent_p.L106L|NR1I3_ENST00000367981.3_Silent_p.L77L|NR1I3_ENST00000502985.1_Intron|NR1I3_ENST00000515621.1_Silent_p.L31L|NR1I3_ENST00000511676.1_Silent_p.L77L			Q14994	NR1I3_HUMAN	nuclear receptor subfamily 1, group I, member 3	106					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	androgen receptor activity|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity|transcription coactivator activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|skin(1)	15	all_cancers(52;1.86e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			GCTCCTTACTCAGTTGCACAG	0.587000													45	950					0	0	1	0	0
GCNT2	2651	broad.mit.edu	37	6	10528976	10528976	+	Translation_Start_Site	SNP	A	A	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr6:10528976A>T	ENST00000379597.3	+	0	388				GCNT2_ENST00000397423.2_3'UTR|GCNT2_ENST00000410107.1_Intron|GCNT2_ENST00000495262.1_De_novo_Start_OutOfFrame			Q8N0V5	GNT2A_HUMAN	glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)							Golgi membrane|integral to membrane	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			endometrium(2)|kidney(1)|large_intestine(5)|lung(2)|ovary(2)	12	Ovarian(93;0.107)|Breast(50;0.148)	all_hematologic(90;0.107)		KIRC - Kidney renal clear cell carcinoma(1;0.099)|Kidney(1;0.119)		AGAGGGGAAGAAGAAAGAAAA	0.473000													3	11					0	0	1	0	0
FAM86C2P	645332	broad.mit.edu	37	11	67559951	67559951	+	RNA	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr11:67559951G>A	ENST00000528089.1	-	0	1799																											CCTGGTAAATGAATTGGTTCT	0.552000													5	13					0	0	1	0	0
RTCA	8634	broad.mit.edu	37	1	100736190	100736190	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:100736190G>T	ENST00000370128.4	+	4	537	c.368G>T	c.(367-369)gGt>gTt	p.G123V	RTCA_ENST00000260563.4_Missense_Mutation_p.G136V|RTCA_ENST00000498617.1_3'UTR	NM_003729.3	NP_003720.1	O00442	RTC1_HUMAN	RNA 3'-terminal phosphate cyclase	123					RNA processing	mitochondrion|nucleoplasm	ATP binding|protein binding|RNA binding|RNA-3'-phosphate cyclase activity										CATTTGAAAGGTGGAACTAAT	0.448000													45	82					1.15183e-24	1.24599e-24	1	1	0
PI4KA	5297	broad.mit.edu	37	22	21188874	21188874	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr22:21188874C>G	ENST00000255882.6	-	3	429	c.343G>C	c.(343-345)Gaa>Caa	p.E115Q	PI4KA_ENST00000572273.1_Missense_Mutation_p.E57Q	NM_058004.3	NP_477352.3	P42356	PI4KA_HUMAN	phosphatidylinositol 4-kinase, catalytic, alpha	57					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|synaptic transmission	Golgi-associated vesicle	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			breast(3)|endometrium(8)|kidney(9)|large_intestine(19)|lung(29)|ovary(1)|pancreas(1)|prostate(3)|salivary_gland(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	79	all_cancers(11;7.59e-25)|all_epithelial(7;1.34e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)			GCTGTGCTTTCTTCTACCCAA	0.338000													26	58					0	0	1	0	0
ZNF318	24149	broad.mit.edu	37	6	43306539	43306539	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr6:43306539G>A	ENST00000361428.2	-	10	5274	c.5197C>T	c.(5197-5199)Cct>Tct	p.P1733S	ZNF318_ENST00000318149.3_Intron	NM_014345.2	NP_055160.2	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	1733					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(21)|ovary(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	61			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			AACAGTTGAGGAGGTGGTTCT	0.468000													23	45					0	0	1	0	0
ZNF845	91664	broad.mit.edu	37	19	53856537	53856537	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:53856537G>C	ENST00000458035.1	+	4	2726	c.2609G>C	c.(2608-2610)aGa>aCa	p.R870T	ZNF845_ENST00000595091.1_Missense_Mutation_p.R870T	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	870					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						GTTTTTAATAGAAAAGCAAAC	0.378000													11	28					0	0	1	0	0
IPCEF1	26034	broad.mit.edu	37	6	154567864	154567864	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr6:154567864G>A	ENST00000265198.4	-	5	259	c.104C>T	c.(103-105)tCg>tTg	p.S35L	OPRM1_ENST00000337049.4_Missense_Mutation_p.R401Q|IPCEF1_ENST00000519344.1_Missense_Mutation_p.S7L|IPCEF1_ENST00000367220.4_Missense_Mutation_p.S36L|IPCEF1_ENST00000422970.2_Missense_Mutation_p.S36L	NM_001130700.1|NM_015553.2	NP_001124172.1|NP_056368.1			interaction protein for cytohesin exchange factors 1											breast(1)|central_nervous_system(2)|endometrium(3)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	12						ATCTTTACACGATATCCTCCT	0.403000													16	56					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32016207	32016207	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr6:32016207G>A	ENST00000375244.3	-	29	10179	c.9978C>T	c.(9976-9978)taC>taT	p.Y3326Y	TNXB_ENST00000375247.2_Silent_p.Y3324Y			P22105	TENX_HUMAN	tenascin XB	3371	Fibronectin type-III 25.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						GCAGGAACTTGTACTTGCGGG	0.682000													29	31					0	0	1	0	0
BEST3	144453	broad.mit.edu	37	12	70065245	70065245	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr12:70065245A>G	ENST00000330891.5	-	9	1289	c.1063T>C	c.(1063-1065)Tgc>Cgc	p.C355R	BEST3_ENST00000476098.1_Missense_Mutation_p.C142R|BEST3_ENST00000553096.1_Missense_Mutation_p.C249R|BEST3_ENST00000331471.4_Missense_Mutation_p.C355R|BEST3_ENST00000488961.1_Missense_Mutation_p.C142R	NM_001282613.1|NM_032735.2	NP_001269542.1|NP_116124.2	Q8N1M1	BEST3_HUMAN	bestrophin 3	355						chloride channel complex|plasma membrane	chloride channel activity			cervix(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(2)	12	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			GAGGGTATGCAGTAGTCAGCA	0.458000													25	694					0	0	1	0	0
PFKM	5213	broad.mit.edu	37	12	48537866	48537866	+	Missense_Mutation	SNP	A	A	G	rs142495522	by1000genomes	TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr12:48537866A>G	ENST00000340802.6	+	22	2355	c.2131A>G	c.(2131-2133)Att>Gtt	p.I711V	PFKM_ENST00000312352.7_Missense_Mutation_p.I640V|PFKM_ENST00000547587.1_Missense_Mutation_p.I640V|PFKM_ENST00000359794.5_Missense_Mutation_p.I640V|PFKM_ENST00000551804.1_Missense_Mutation_p.I609V|PFKM_ENST00000395233.2_Missense_Mutation_p.I609V	NM_001166686.1	NP_001160158.1	P08237	K6PF_HUMAN	phosphofructokinase, muscle	640					fructose 6-phosphate metabolic process|glycolysis|muscle cell homeostasis	6-phosphofructokinase complex|apical plasma membrane	6-phosphofructokinase activity|ATP binding|identical protein binding|kinase binding|metal ion binding|protein C-terminus binding			NS(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(16)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	35						CACTGACTTCATTTTCAACCT	0.512000													45	121					0	0	1	0	0
MASP1	5648	broad.mit.edu	37	3	186953885	186953885	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:186953885C>G	ENST00000296280.6	-	11	1999	c.1774G>C	c.(1774-1776)Ggc>Cgc	p.G592R	MASP1_ENST00000392472.2_Missense_Mutation_p.G479R|MASP1_ENST00000495249.1_5'UTR|MASP1_ENST00000337774.5_Intron	NM_139125.3	NP_624302.1	P48740	MASP1_HUMAN	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	588	Peptidase S1.				complement activation, lectin pathway|negative regulation of complement activation|proteolysis	extracellular space	calcium ion binding|calcium-dependent protein binding|protein binding|protein homodimerization activity|serine-type endopeptidase activity			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|liver(2)|lung(27)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	60	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.49e-18)	GBM - Glioblastoma multiforme(93;0.0366)		ATGCCCCAGCCGGCCACCAGG	0.617000													17	84					0	0	1	0	0
HEPH	9843	broad.mit.edu	37	X	65392276	65392276	+	Translation_Start_Site	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chrX:65392276G>A	ENST00000336279.5	+	0	284				HEPH_ENST00000374727.3_Missense_Mutation_p.D86N|HEPH_ENST00000419594.1_Missense_Mutation_p.D86N|HEPH_ENST00000343002.2_Missense_Mutation_p.D83N|HEPH_ENST00000441993.2_Missense_Mutation_p.D86N|HEPH_ENST00000519389.1_Missense_Mutation_p.D137N	NM_014799.2	NP_055614.1	Q9BQS7	HEPH_HUMAN	hephaestin						cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|lung(56)|ovary(5)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	89						AGAATACAAGGATGACTCATA	0.483000													15	28					0	0	1	0	0
LOC146880	146880	broad.mit.edu	37	17	62746753	62746753	+	RNA	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr17:62746753G>A	ENST00000400873.3	-	0	2473					NR_026899.1																						AGTCAGATACGGAGGAAATCC	0.552000													15	45					0	0	1	0	0
CCDC147	159686	broad.mit.edu	37	10	106139804	106139804	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr10:106139804C>T	ENST00000369704.3	+	9	1325	c.1191C>T	c.(1189-1191)gtC>gtT	p.V397V	CCDC147_ENST00000312902.5_Silent_p.V19V|CCDC147_ENST00000369703.1_Silent_p.V19V	NM_001008723.1	NP_001008723.1	Q5T655	CC147_HUMAN	coiled-coil domain containing 147	397										NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	52		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;7.55e-10)|all cancers(201;3.37e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0189)		TTAAGGCGGTCAATGCGACCC	0.453000													16	61					0	0	1	0	0
SPHK2	56848	broad.mit.edu	37	19	49132182	49132182	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:49132182C>T	ENST00000443164.1	+	5	2008	c.1303C>T	c.(1303-1305)Cgc>Tgc	p.R435C	SPHK2_ENST00000600537.1_Missense_Mutation_p.R314C|SPHK2_ENST00000598088.1_Missense_Mutation_p.R373C|SPHK2_ENST00000599029.1_Missense_Mutation_p.R337C|SPHK2_ENST00000599748.1_Missense_Mutation_p.R337C|SPHK2_ENST00000245222.4_Missense_Mutation_p.R373C|SPHK2_ENST00000340932.3_Missense_Mutation_p.R335C			Q9NRA0	SPHK2_HUMAN	sphingosine kinase 2	373					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis|cell proliferation|sphinganine-1-phosphate biosynthetic process	cytosol|lysosomal membrane|membrane fraction	ATP binding|D-erythro-sphingosine kinase activity|diacylglycerol kinase activity|Ras GTPase binding|sphinganine kinase activity			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(4)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	19		all_lung(116;0.000125)|Lung NSC(112;0.000202)|all_epithelial(76;0.000283)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000102)|all cancers(93;0.000117)|GBM - Glioblastoma multiforme(486;0.00627)|Epithelial(262;0.0158)		GCACACCTACCGCGGACGCCT	0.662000													15	68					0	0	1	0	0
CDKL2	8999	broad.mit.edu	37	4	76532404	76532404	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr4:76532404C>G	ENST00000429927.2	-	4	1208	c.505G>C	c.(505-507)Gct>Cct	p.A169P	CDKL2_ENST00000307465.4_Missense_Mutation_p.A169P	NM_003948.3	NP_003939.1	Q92772	CDKL2_HUMAN	cyclin-dependent kinase-like 2 (CDC2-related kinase)	169	Protein kinase.				sex differentiation|signal transduction	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity			breast(3)|endometrium(1)|large_intestine(4)|lung(6)|ovary(2)|prostate(2)|skin(2)|stomach(2)	22			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			AGTTCTGGAGCTCTGTACCAT	0.453000													14	33					0	0	1	0	0
TAF15	8148	broad.mit.edu	37	17	34171988	34171988	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr17:34171988G>A	ENST00000588240.1	+	15	1800	c.1685G>A	c.(1684-1686)cGa>cAa	p.R562Q	TAF15_ENST00000592237.1_Missense_Mutation_p.E367K|TAF15_ENST00000311979.3_Missense_Mutation_p.R559Q	NM_003487.3|NM_139215.2	NP_003478.1|NP_631961.1	Q92804	RBP56_HUMAN	TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa	562	21 X approximate tandem repeats of D-R- [S,G](0,3)-G-G-Y-G-G.|Arg/Gly-rich.				positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|nucleotide binding|protein binding|RNA binding|zinc ion binding		TAF15/NR4A3(33)	lung(1)|ovary(1)|skin(2)|stomach(1)	5		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0193)		GGAGGAGACCGAGGTGGGGGC	0.567000			T	"""TEC, CHN1, ZNF384"""	"""extraskeletal myxoid chondrosarcomas, ALL"""								38	92					0	0	1	0	0
MAPKAPK5	8550	broad.mit.edu	37	12	112326395	112326395	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr12:112326395C>T	ENST00000550735.2	+	11	1829	c.1073C>T	c.(1072-1074)cCc>cTc	p.P358L	MAPKAPK5_ENST00000551404.2_Missense_Mutation_p.P358L	NM_003668.2|NM_139078.1	NP_003659.2|NP_620777.1	Q8IW41	MAPK5_HUMAN	mitogen-activated protein kinase-activated protein kinase 5	358					signal transduction	cytoplasm|nucleus	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity			endometrium(1)|lung(11)|ovary(1)	13						GTGAACAACCCCATTCTGCGG	0.478000													29	93					0	0	1	0	0
SOX4	6659	broad.mit.edu	37	6	21595158	21595158	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr6:21595158G>A	ENST00000244745.1	+	1	1187	c.393G>A	c.(391-393)agG>agA	p.R131R	SOX4_ENST00000543472.1_Silent_p.R131R	NM_003107.2	NP_003098.1	Q06945	SOX4_HUMAN	SRY (sex determining region Y)-box 4	131					canonical Wnt receptor signaling pathway|cardiac ventricle formation|cellular response to glucose stimulus|DNA damage response, detection of DNA damage|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|glial cell development|glial cell proliferation|limb bud formation|negative regulation of apoptosis|negative regulation of cell proliferation|negative regulation of protein export from nucleus|negative regulation of protein ubiquitination|neural tube formation|neuroepithelial cell differentiation|noradrenergic neuron differentiation|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|positive regulation of insulin secretion|positive regulation of N-terminal peptidyl-lysine acetylation|positive regulation of translation|pro-B cell differentiation|protein stabilization|skeletal system development|spinal cord motor neuron differentiation|sympathetic nervous system development|T cell differentiation	mitochondrion|nucleus	core promoter sequence-specific DNA binding|protein binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription coactivator activity			kidney(2)|lung(2)|prostate(1)|upper_aerodigestive_tract(1)	6	Ovarian(93;0.163)		all cancers(50;0.0751)|Epithelial(50;0.155)			ACCGGCCCAGGAAGAAGGTGA	0.642000													4	20					0	0	1	0	0
LPIN1	23175	broad.mit.edu	37	2	11911713	11911713	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:11911713G>C	ENST00000256720.2	+	4	597	c.504G>C	c.(502-504)aaG>aaC	p.K168N	LPIN1_ENST00000425416.2_Missense_Mutation_p.K174N|LPIN1_ENST00000396099.1_Missense_Mutation_p.K174N|LPIN1_ENST00000449576.2_Missense_Mutation_p.K217N|LPIN1_ENST00000396098.1_Missense_Mutation_p.K174N	NM_145693.2	NP_663731.1	Q14693	LPIN1_HUMAN	lipin 1	168					fatty acid catabolic process|transcription, DNA-dependent|triglyceride biosynthetic process|triglyceride mobilization	cytosol|endoplasmic reticulum membrane	phosphatidate phosphatase activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(15)|liver(1)|lung(10)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	45	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.11)|OV - Ovarian serous cystadenocarcinoma(76;0.173)		ACAGCCTGAAGAGAGATGACA	0.527000													3	20					0	0	1	0	0
UCK1	83549	broad.mit.edu	37	9	134405894	134405894	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr9:134405894G>A	ENST00000372215.4	-	2	340	c.247C>T	c.(247-249)Cag>Tag	p.Q83*	UCK1_ENST00000372210.3_Nonsense_Mutation_p.Q74*|UCK1_ENST00000372211.3_Nonsense_Mutation_p.Q88*|UCK1_ENST00000459858.1_5'UTR|UCK1_ENST00000372208.3_Nonsense_Mutation_p.Q83*	NM_001261450.1|NM_001261451.1|NM_031432.2	NP_001248379.1|NP_001248380.1|NP_113620.1	Q9HA47	UCK1_HUMAN	uridine-cytidine kinase 1	83					pyrimidine base metabolic process|pyrimidine nucleoside salvage	cytosol	ATP binding|phosphotransferase activity, alcohol group as acceptor|uridine kinase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|skin(1)|upper_aerodigestive_tract(1)	6				OV - Ovarian serous cystadenocarcinoma(145;2.34e-05)|Epithelial(140;0.000219)		AAATTGTACTGTCCTTTCAAG	0.597000													23	94					0	0	1	0	0
JAG1	182	broad.mit.edu	37	20	10621842	10621842	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr20:10621842C>G	ENST00000254958.5	-	24	3482	c.2967G>C	c.(2965-2967)ttG>ttC	p.L989F	JAG1_ENST00000423891.2_Missense_Mutation_p.L830F	NM_000214.2	NP_000205.1	P78504	JAG1_HUMAN	jagged 1	989					angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(14)|ovary(2)|pancreas(1)|urinary_tract(1)	44						AAACATTCTTCAAAATATTCA	0.393000									Alagille Syndrome				32	41					0	0	1	0	0
TDRD3	81550	broad.mit.edu	37	13	61102816	61102816	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr13:61102816C>T	ENST00000196169.3	+	11	1966	c.1178C>T	c.(1177-1179)cCt>cTt	p.P393L	TDRD3_ENST00000535286.1_Missense_Mutation_p.P486L|TDRD3_ENST00000377881.2_Missense_Mutation_p.P393L|TDRD3_ENST00000377894.2_Missense_Mutation_p.P393L	NM_001146071.1|NM_030794.2	NP_001139543.1|NP_110421.1	Q9H7E2	TDRD3_HUMAN	tudor domain containing 3	393					chromatin modification	cytoplasm|nucleus	chromatin binding|methylated histone residue binding|nucleic acid binding|transcription coactivator activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|liver(1)|lung(16)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	40		Prostate(109;0.173)|Breast(118;0.174)		GBM - Glioblastoma multiforme(99;0.000291)		ACTTCATATCCTTTAGGTTCT	0.373000													12	31					0	0	1	0	0
MATN1	4146	broad.mit.edu	37	1	31189102	31189102	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:31189102C>A	ENST00000373765.4	-	5	896	c.861G>T	c.(859-861)agG>agT	p.R287S	MATN1_ENST00000477320.1_5'UTR	NM_002379.3	NP_002370.1	P21941	MATN1_HUMAN	matrilin 1, cartilage matrix protein	287	VWFA 2.				protein complex assembly	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)	12		Colorectal(325;0.00792)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)|Ovarian(437;0.0563)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		Colorectal(126;1.29e-05)|COAD - Colon adenocarcinoma(152;0.000726)|STAD - Stomach adenocarcinoma(196;0.0183)|READ - Rectum adenocarcinoma(331;0.0649)		AGTTCTCTGGCCTCACACTCT	0.567000													13	44					7.93312e-07	8.28475e-07	1	1	0
RPS6KA6	27330	broad.mit.edu	37	X	83419374	83419374	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chrX:83419374C>T	ENST00000262752.2	-	2	110	c.103G>A	c.(103-105)Gat>Aat	p.D35N	RPS6KA6_ENST00000543399.1_Missense_Mutation_p.D35N	NM_014496.4	NP_055311.1	Q9UK32	KS6A6_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 6	35					axon guidance|central nervous system development|intracellular protein kinase cascade|synaptic transmission	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(26)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	46						ATTGGCTCATCAACCATTTTA	0.308000													5	15					0	0	1	0	0
DNAH1	25981	broad.mit.edu	37	3	52425569	52425569	+	Silent	SNP	G	G	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:52425569G>T	ENST00000420323.2	+	63	10263	c.10002G>T	c.(10000-10002)acG>acT	p.T3334T		NM_015512.4	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	3399	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		CACACTACACGCCCGAGATCT	0.597000													9	25					0.000274275	0.000279778	1	1	0
PKHD1	5314	broad.mit.edu	37	6	51889428	51889428	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr6:51889428G>A	ENST00000371117.3	-	32	5455	c.5180C>T	c.(5179-5181)tCa>tTa	p.S1727L	PKHD1_ENST00000340994.4_Missense_Mutation_p.S1727L	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	1727	IPT/TIG 12; atypical.				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					CAGGGCAGATGAGGCCCACCC	0.507000													22	66					0	0	1	0	0
KIAA0196	9897	broad.mit.edu	37	8	126062839	126062839	+	Silent	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr8:126062839C>G	ENST00000318410.7	-	18	2515	c.2166G>C	c.(2164-2166)ctG>ctC	p.L722L	KIAA0196_ENST00000517845.1_Silent_p.L574L	NM_014846.3	NP_055661.3	Q12768	STRUM_HUMAN	KIAA0196	722					cell death	WASH complex				NS(1)|breast(3)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	42	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			GTCCCCTATGCAGGGCAAAGG	0.498000													17	92					0	0	1	0	0
CPA3	1359	broad.mit.edu	37	3	148583134	148583134	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:148583134C>T	ENST00000296046.3	+	1	92	c.40C>T	c.(40-42)Ctt>Ttt	p.L14F	RP11-680B3.2_ENST00000488190.1_RNA	NM_001870.2	NP_001861.2	P15088	CBPA3_HUMAN	carboxypeptidase A3 (mast cell)	14					proteolysis	stored secretory granule|transport vesicle	metallocarboxypeptidase activity|zinc ion binding			NS(1)|breast(3)|endometrium(1)|large_intestine(3)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	35			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			TGCTACCACTCTTGCAATTGC	0.453000													16	98					0	0	1	0	0
POM121C	100101267	broad.mit.edu	37	7	75066940	75066940	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr7:75066940G>A	ENST00000453279.2	-	7	1197	c.333C>T	c.(331-333)ctC>ctT	p.L111L	POM121C_ENST00000257665.5_Silent_p.L353L	NM_001099415.1	NP_001092885	A8CG34	P121C_HUMAN	POM121 transmembrane nucleoporin C	353	Pore side (Potential).|Required for targeting to the nucleus and nuclear pore complex.				mRNA transport|protein transport|transmembrane transport	endoplasmic reticulum membrane|nuclear membrane|nuclear pore	protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)|skin(1)|urinary_tract(1)	14						TCTGAGAATTGAGGCCTCTCT	0.468000													27	56					0	0	1	0	0
TTC5	91875	broad.mit.edu	37	14	20767554	20767554	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr14:20767554C>T	ENST00000258821.3	-	4	506	c.450G>A	c.(448-450)cgG>cgA	p.R150R		NM_138376.2	NP_612385.2	Q8N0Z6	TTC5_HUMAN	tetratricopeptide repeat domain 5	150					DNA repair	cytoplasm|nucleus	binding			endometrium(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)	15	all_cancers(95;0.00092)		Epithelial(56;1.1e-06)|all cancers(55;8.07e-06)	GBM - Glioblastoma multiforme(265;0.0106)		CAGTGTCAGTCCGCAGCTGAC	0.502000													19	77					0	0	1	0	0
TUSC5	286753	broad.mit.edu	37	17	1183494	1183494	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr17:1183494G>A	ENST00000333813.3	+	1	538	c.199G>A	c.(199-201)Gag>Aag	p.E67K		NM_172367.2	NP_758955.2	Q8IXB3	TUSC5_HUMAN	tumor suppressor candidate 5	67					response to biotic stimulus	integral to membrane				endometrium(2)|kidney(2)|large_intestine(3)|lung(2)|prostate(4)|skin(2)	15				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		GGCCATCTCCGAGGGGCACCT	0.632000													19	34					0	0	1	0	0
OSMR	9180	broad.mit.edu	37	5	38924610	38924610	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr5:38924610C>G	ENST00000274276.3	+	14	2359	c.1957C>G	c.(1957-1959)Caa>Gaa	p.Q653E		NM_003999.2	NP_003990.1	Q99650	OSMR_HUMAN	oncostatin M receptor	653	Fibronectin type-III 4.				cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity	p.Q653*(1)		NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(8)|lung(20)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	46	all_lung(31;0.000365)					TACTGAATCTCAACCTGGTTT	0.448000													16	70					0	0	1	0	0
ERCC2	2068	broad.mit.edu	37	19	45872219	45872219	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:45872219T>C	ENST00000391945.4	-	4	292	c.215A>G	c.(214-216)tAc>tGc	p.Y72C	ERCC2_ENST00000391940.4_Missense_Mutation_p.Y48C|ERCC2_ENST00000391944.3_Missense_Mutation_p.Y72C|ERCC2_ENST00000221481.6_Missense_Mutation_p.Y72C|ERCC2_ENST00000485403.2_Missense_Mutation_p.Y48C	NM_000400.3	NP_000391.1	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 2	72	Helicase ATP-binding.				cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			large_intestine(4)|lung(2)|ovary(1)|pancreas(1)|stomach(1)	9		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		TCTTGAGCAGTAGATGAGTTT	0.577000			"""Mis, N, F, S"""			"""skin basal cell, skin squamous cell, melanoma"""		Nucleotide excision repair (NER)	Xeroderma Pigmentosum				29	123					0	0	1	0	0
ADRA2C	152	broad.mit.edu	37	4	3768916	3768916	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr4:3768916G>A	ENST00000330055.5	+	1	792	c.583G>A	c.(583-585)Gac>Aac	p.D195N	ADRA2C_ENST00000509482.1_Missense_Mutation_p.D195N	NM_000683.3	NP_000674.2	P18825	ADA2C_HUMAN	adrenoceptor alpha 2C	195					activation of MAPK activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cell-cell signaling|energy reserve metabolic process|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|negative regulation of epinephrine secretion|negative regulation of norepinephrine secretion|positive regulation of neuron differentiation|regulation of insulin secretion	endosome|integral to plasma membrane	alpha-2A adrenergic receptor binding|alpha2-adrenergic receptor activity|epinephrine binding|protein heterodimerization activity|protein homodimerization activity			endometrium(2)|kidney(1)|large_intestine(1)|lung(4)	8				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)	Bethanidine(DB00217)|Brimonidine(DB00484)|Debrisoquin(DB04840)|Fenoldopam(DB00800)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Lofexidine(DB04948)|Norepinephrine(DB00368)|Yohimbine(DB01392)	CCGCCAGCCCGACGGCGCCGC	0.677000													8	19					0	0	1	0	0
BTC	685	broad.mit.edu	37	4	75673319	75673319	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr4:75673319C>T	ENST00000395743.3	-	5	829	c.469G>A	c.(469-471)Gaa>Aaa	p.E157K		NM_001729.2	NP_001720.1	P35070	BTC_HUMAN	betacellulin	157					positive regulation of cell division|positive regulation of cell proliferation	extracellular space|integral to membrane|plasma membrane|soluble fraction	epidermal growth factor receptor binding|growth factor activity			central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(3)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	10			Lung(101;0.219)			GTTTCCATTTCTTCTTCTTTC	0.343000													14	27					0	0	1	0	0
DZIP1L	199221	broad.mit.edu	37	3	137822349	137822349	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:137822349C>G	ENST00000327532.2	-	2	827	c.465G>C	c.(463-465)caG>caC	p.Q155H	DZIP1L_ENST00000469243.1_Missense_Mutation_p.Q155H	NM_173543.2	NP_775814.2	Q8IYY4	DZI1L_HUMAN	DAZ interacting zinc finger protein 1-like	155						intracellular	zinc ion binding			breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(1)|pancreas(2)|prostate(1)|skin(1)	35						GCATTAGCAGCTGCTGCAGGG	0.652000													15	36					0	0	1	0	0
CREG2	200407	broad.mit.edu	37	2	101967409	101967409	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:101967409G>A	ENST00000324768.5	-	4	986	c.849C>T	c.(847-849)ttC>ttT	p.F283F		NM_153836.3	NP_722578.1	Q8IUH2	CREG2_HUMAN	cellular repressor of E1A-stimulated genes 2							extracellular region	FMN binding			endometrium(1)|large_intestine(3)|lung(4)|ovary(1)|skin(1)	10						GAACTGCTTTGAAATATTCCT	0.418000													20	53					0	0	1	0	0
INVS	27130	broad.mit.edu	37	9	103062879	103062879	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr9:103062879G>C	ENST00000262457.2	+	17	3306	c.3121G>C	c.(3121-3123)Gag>Cag	p.E1041Q	INVS_ENST00000262456.2_Missense_Mutation_p.E871Q	NM_014425.3	NP_055240.2	Q9Y283	INVS_HUMAN	inversin	1041					negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasm|membrane|microtubule|nucleus|spindle	calmodulin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(5)|ovary(4)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	31		Acute lymphoblastic leukemia(62;0.056)				ACATCTCCTTGAGAACAGTGG	0.363000													5	26					0	0	1	0	0
ZNF148	7707	broad.mit.edu	37	3	124952257	124952257	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:124952257G>A	ENST00000360647.4	-	9	1798	c.1313C>T	c.(1312-1314)tCa>tTa	p.S438L	ZNF148_ENST00000468369.1_Intron|ZNF148_ENST00000484491.1_Missense_Mutation_p.S438L|ZNF148_ENST00000544464.1_Intron|ZNF148_ENST00000492394.1_Missense_Mutation_p.S438L|ZNF148_ENST00000485866.1_Missense_Mutation_p.S438L|SLC12A8_ENST00000423114.2_Intron|ZNF148_ENST00000497929.1_5'UTR	NM_021964.2	NP_068799.2	Q9UQR1	ZN148_HUMAN	zinc finger protein 148	438					cellular defense response|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			breast(3)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(3)|liver(1)|lung(6)|ovary(1)|pancreas(1)|prostate(2)|skin(3)	28						ATTGCCTTCTGAGTCCAGTAA	0.393000													20	89					0	0	1	0	0
TCHH	7062	broad.mit.edu	37	1	152084422	152084422	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:152084422T>C	ENST00000368804.1	-	2	1270	c.1271A>G	c.(1270-1272)cAg>cGg	p.Q424R		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	424	8 X 6 AA tandem repeats of R-R-E-Q-Q-L.				keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCGCCTCAGCTGCTGCTCGCG	0.706000													19	115					0	0	1	0	0
HELZ2	85441	broad.mit.edu	37	20	62200074	62200074	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr20:62200074G>C	ENST00000467148.1	-	5	1436	c.1367C>G	c.(1366-1368)gCc>gGc	p.A456G		NM_001037335.2	NP_001032412.2			helicase with zinc finger 2, transcriptional coactivator																		CAGCCCCAGGGCCAAGCAGCA	0.672000													3	4					0	0	1	0	0
DCLK2	166614	broad.mit.edu	37	4	151141927	151141927	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr4:151141927G>C	ENST00000296550.7	+	6	1883	c.1129G>C	c.(1129-1131)Gaa>Caa	p.E377Q	DCLK2_ENST00000302176.8_Missense_Mutation_p.E394Q|DCLK2_ENST00000506325.1_Missense_Mutation_p.E376Q	NM_001040260.3	NP_001035350.2	Q8N568	DCLK2_HUMAN	doublecortin-like kinase 2	377					intracellular signal transduction	cytoplasm|cytoskeleton	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(7)|ovary(3)|pancreas(1)|prostate(1)|skin(1)	26	all_hematologic(180;0.151)					CATAAGTCCTGAAGGTAGTTC	0.413000													9	26					0	0	1	0	0
DUSP12	11266	broad.mit.edu	37	1	161721656	161721656	+	Splice_Site	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:161721656G>A	ENST00000367943.4	+	3	491	c.459G>A	c.(457-459)aaG>aaA	p.K153K		NM_007240.1	NP_009171.1	Q9UNI6	DUS12_HUMAN	dual specificity phosphatase 12	153	Tyrosine-protein phosphatase.				positive regulation of glucokinase activity	cytoplasm|nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|lung(1)	5	all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00634)			ATCATTACAGGATGAATGAGG	0.318000													9	43					0	0	1	0	0
AGPAT4	56895	broad.mit.edu	37	6	161560503	161560503	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr6:161560503C>G	ENST00000320285.4	-	8	1205	c.993G>C	c.(991-993)agG>agC	p.R331S	AGPAT4_ENST00000366911.5_3'UTR|AGPAT4_ENST00000457520.2_Missense_Mutation_p.R169S	NM_020133.2	NP_064518.1	Q9NRZ5	PLCD_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 4	331					phospholipid biosynthetic process	integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity|protein binding			endometrium(1)|large_intestine(10)|lung(10)|ovary(2)|skin(2)	25		Breast(66;0.000289)|Ovarian(120;0.0266)|Prostate(117;0.0285)		OV - Ovarian serous cystadenocarcinoma(65;2.23e-17)|BRCA - Breast invasive adenocarcinoma(81;3.58e-05)		AAGACCCGCTCCTGATCATGC	0.632000													39	117					0	0	1	0	0
P2RY1	5028	broad.mit.edu	37	3	152554519	152554519	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:152554519C>T	ENST00000305097.3	+	1	1784	c.948C>T	c.(946-948)aaC>aaT	p.N316N		NM_002563.3	NP_002554.1	P47900	P2RY1_HUMAN	purinergic receptor P2Y, G-protein coupled, 1	316					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|platelet activation	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			breast(1)|endometrium(1)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)	23			LUSC - Lung squamous cell carcinoma(72;0.0628)|Lung(72;0.11)			CAAGTCTCAACAGTTGTGTGG	0.483000													19	117					0	0	1	0	0
TTC13	79573	broad.mit.edu	37	1	231079566	231079566	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:231079566C>G	ENST00000366661.4	-	6	665	c.658G>C	c.(658-660)Gag>Cag	p.E220Q	TTC13_ENST00000366662.4_Intron|TTC13_ENST00000414259.1_Intron	NM_024525.4	NP_078801.3	Q8NBP0	TTC13_HUMAN	tetratricopeptide repeat domain 13	220							binding			central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(9)|lung(16)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	39	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)		COAD - Colon adenocarcinoma(196;0.243)		GCTCGCTGCTCAAATACCTCT	0.378000													19	90					0	0	1	0	0
RNF217	154214	broad.mit.edu	37	6	125283978	125283978	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr6:125283978C>T	ENST00000521654.2	+	1	288	c.288C>T	c.(286-288)ctC>ctT	p.L96L	RP11-510H23.1_ENST00000439075.1_RNA|RNF217_ENST00000560949.1_5'UTR			Q8TC41	RN217_HUMAN	ring finger protein 217	0					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	integral to membrane	ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)|skin(1)|urinary_tract(1)	11			LUSC - Lung squamous cell carcinoma(4;0.0263)|Lung(4;0.0828)	GBM - Glioblastoma multiforme(226;0.0162)		CCGGGCCTCTCAATCCCCAGA	0.687000													11	35					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	106960959	106960959	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr10:106960959T>G	ENST00000369701.3	+	16	2436	c.2209T>G	c.(2209-2211)Tca>Gca	p.S737A	SORCS3_ENST00000369699.4_Missense_Mutation_p.S23A	NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	737						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		CCGAGACCACTCAGGATCAGT	0.488000													26	70					0	0	1	0	0
FAM72A	729533	broad.mit.edu	37	1	206145485	206145485	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:206145485C>A	ENST00000367128.3	+	3	1110	c.262C>A	c.(262-264)Cca>Aca	p.P88T	FAM72A_ENST00000470041.1_3'UTR|FAM72A_ENST00000341209.5_Missense_Mutation_p.P48T|FAM72A_ENST00000367129.2_Missense_Mutation_p.P88T			Q5TYM5	FA72A_HUMAN	family with sequence similarity 72, member A	88										endometrium(2)	2						TGTGATTGTTCCATGTAGTTC	0.373000													63	72					8.07507e-42	8.81414e-42	1	1	0
C16orf87	388272	broad.mit.edu	37	16	46836948	46836948	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr16:46836948G>A	ENST00000394806.2	-	3	210	c.198C>T	c.(196-198)aaC>aaT	p.N66N	C16orf87_ENST00000285697.4_Silent_p.N127N|C16orf87_ENST00000564250.1_5'UTR			Q6PH81	CP087_HUMAN	chromosome 16 open reading frame 87	127										large_intestine(4)|urinary_tract(1)	5						CATCAGACAGGTTAGCATAGA	0.299000													15	18					0	0	1	0	0
SLC9C1	285335	broad.mit.edu	37	3	111950214	111950214	+	Silent	SNP	T	T	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:111950214T>C	ENST00000305815.5	-	13	1818	c.1566A>G	c.(1564-1566)gcA>gcG	p.A522A	SLC9C1_ENST00000487372.1_Silent_p.A474A	NM_183061.1	NP_898884.1	Q4G0N8	S9A10_HUMAN	solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1	522					cell differentiation|multicellular organismal development|sodium ion transport|spermatogenesis	cilium|flagellar membrane|integral to membrane	solute:hydrogen antiporter activity										GTACTATTTGTGCTGACAAGA	0.358000													13	48					0	0	1	0	0
CACNG3	10368	broad.mit.edu	37	16	24372723	24372723	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr16:24372723G>A	ENST00000005284.3	+	4	1689	c.487G>A	c.(487-489)Gac>Aac	p.D163N		NM_006539.3	NP_006530.1	O60359	CCG3_HUMAN	calcium channel, voltage-dependent, gamma subunit 3	163					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(1)|endometrium(4)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|prostate(4)|skin(2)	40				GBM - Glioblastoma multiforme(48;0.0809)		CAACGCCGGAGACCCCGGGCA	0.448000													33	216					0	0	1	0	0
CELSR3	1951	broad.mit.edu	37	3	48679390	48679390	+	Silent	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:48679390G>C	ENST00000544264.1	-	33	9013	c.8733C>G	c.(8731-8733)ctC>ctG	p.L2911L	CELSR3_ENST00000164024.4_Silent_p.L2906L			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	2906					homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		ATGGAATGGAGAGACTCCTCT	0.592000													5	20					0	0	1	0	0
FAM63A	55793	broad.mit.edu	37	1	150974766	150974766	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:150974766C>T	ENST00000361936.5	-	3	1282	c.328G>A	c.(328-330)Gag>Aag	p.E110K	FAM63A_ENST00000312210.5_5'UTR|FAM63A_ENST00000470877.1_Intron|FAM63A_ENST00000493834.2_Missense_Mutation_p.E15K|FAM63A_ENST00000361738.6_Missense_Mutation_p.E158K	NM_018379.4	NP_060849	Q8N5J2	FA63A_HUMAN	family with sequence similarity 63, member A	110							protein binding			breast(1)|endometrium(3)|large_intestine(4)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	23	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			AAATCTGGCTCAGGCTGTCGG	0.572000													24	201					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90281277	90281277	+	Silent	SNP	T	T	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr5:90281277T>A	ENST00000405460.2	+	85	18186	c.18090T>A	c.(18088-18090)gtT>gtA	p.V6030V	GPR98_ENST00000425867.2_Silent_p.V1691V	NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	6030					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TCCTCATAGTTATTTTGAAAG	0.443000													9	9					0	0	1	0	0
PPM1E	22843	broad.mit.edu	37	17	57033080	57033080	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr17:57033080T>C	ENST00000308249.2	+	2	664	c.535T>C	c.(535-537)Tct>Cct	p.S179P		NM_014906.4	NP_055721.3	Q8WY54	PPM1E_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1E	188					protein dephosphorylation	cytoplasm|nucleolus|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			biliary_tract(1)|breast(3)|endometrium(4)|kidney(2)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(2)	33	Medulloblastoma(34;0.127)|all_neural(34;0.237)		BRCA - Breast invasive adenocarcinoma(1;5.76e-11)			GAGTGATCTTTCTGCACATTA	0.393000													31	73					0	0	1	0	0
RLN1	6013	broad.mit.edu	37	9	5339740	5339740	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr9:5339740G>A	ENST00000223858.4	-	1	133	c.7C>T	c.(7-9)Cgc>Tgc	p.R3C	RLN1_ENST00000223862.1_Missense_Mutation_p.R3C			P04808	REL1_HUMAN	relaxin 1	3					female pregnancy|signal transduction	extracellular region	hormone activity			large_intestine(1)|lung(4)	5	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.02)|Lung(218;0.0984)		AAGAACAGGCGAGGCATCCTG	0.547000													70	64					0	0	1	0	0
BMPR1B	658	broad.mit.edu	37	4	96046237	96046237	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr4:96046237C>T	ENST00000515059.1	+	8	833	c.550C>T	c.(550-552)Cag>Tag	p.Q184*	BMPR1B_ENST00000394931.1_Nonsense_Mutation_p.Q184*|BMPR1B_ENST00000440890.2_Nonsense_Mutation_p.Q214*|BMPR1B_ENST00000264568.4_Nonsense_Mutation_p.Q184*	NM_001203.2	NP_001194.1	O00238	BMR1B_HUMAN	bone morphogenetic protein receptor, type IB	184	GS.				BMP signaling pathway|cartilage condensation|eye development|limb morphogenesis|ovarian cumulus expansion|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	receptor complex	ATP binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta receptor activity			breast(3)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(11)|lung(8)|ovary(1)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	31		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.51e-07)		TGAGCAGTCTCAGAGCTCAGG	0.418000													12	25					0	0	1	0	0
PPP5C	5536	broad.mit.edu	37	19	46893381	46893381	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:46893381A>T	ENST00000012443.4	+	12	1532	c.1429A>T	c.(1429-1431)Aca>Tca	p.T477S	PPP5C_ENST00000391919.1_Missense_Mutation_p.T349S	NM_006247.3	NP_006238.1	P53041	PPP5_HUMAN	protein phosphatase 5, catalytic subunit	477	Catalytic.				mitosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein dephosphorylation|transcription, DNA-dependent	Golgi apparatus|nucleus	metal ion binding|protein binding|protein serine/threonine phosphatase activity|signal transducer activity			endometrium(4)|kidney(1)|large_intestine(5)|liver(2)|lung(4)|ovary(1)|pancreas(1)	18		Ovarian(192;0.0731)|all_neural(266;0.196)		OV - Ovarian serous cystadenocarcinoma(262;0.000196)|all cancers(93;0.00192)|GBM - Glioblastoma multiforme(486;0.0499)|Epithelial(262;0.0504)		CCACCAGTTCACAGCAGTGGT	0.637000													35	37					0	0	1	0	0
PTPRA	5786	broad.mit.edu	37	20	2945684	2945684	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr20:2945684C>G	ENST00000216877.6	+	5	651	c.251C>G	c.(250-252)tCt>tGt	p.S84C	PTPRA_ENST00000399903.2_Missense_Mutation_p.S84C|PTPRA_ENST00000318266.5_Missense_Mutation_p.S84C|PTPRA_ENST00000356147.3_Missense_Mutation_p.S84C|PTPRA_ENST00000380393.3_Missense_Mutation_p.S84C|PTPRA_ENST00000425918.2_Missense_Mutation_p.S95C|PTPRA_ENST00000358719.4_5'UTR	NM_080840.2	NP_543030.1	P18433	PTPRA_HUMAN	protein tyrosine phosphatase, receptor type, A	84					axon guidance|protein phosphorylation	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|endometrium(3)|large_intestine(3)|lung(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						TCTTCAGACTCTGACAATGGG	0.433000													24	94					0	0	1	0	0
GPATCH2L	55668	broad.mit.edu	37	14	76668107	76668107	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr14:76668107G>A	ENST00000261530.7	+	10	1428	c.1362G>A	c.(1360-1362)gtG>gtA	p.V454V	GPATCH2L_ENST00000556675.1_Intron|GPATCH2L_ENST00000312858.5_Silent_p.V449V	NM_017926.2	NP_060396.2			G patch domain containing 2-like																		AGTGGTTGGTGAGGACCTCTG	0.498000													45	32					0	0	1	0	0
ZGPAT	84619	broad.mit.edu	37	20	62339939	62339939	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr20:62339939G>A	ENST00000328969.5	+	2	134	c.7G>A	c.(7-9)Gag>Aag	p.E3K	ZGPAT_ENST00000369967.3_Missense_Mutation_p.E3K|ZGPAT_ENST00000355969.6_Missense_Mutation_p.E3K|ZGPAT_ENST00000448100.2_Missense_Mutation_p.E3K|ZGPAT_ENST00000357119.4_Missense_Mutation_p.E3K	NM_032527.4	NP_115916.3	Q8N5A5	ZGPAT_HUMAN	zinc finger, CCCH-type with G patch domain	3					negative regulation of epidermal growth factor receptor activity|negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(1)	14	all_cancers(38;1.13e-12)|all_epithelial(29;2.64e-14)|Lung NSC(23;4.79e-10)|all_lung(23;1.7e-09)					CAGCATGGACGAGGAGAGCCT	0.682000													6	34					0	0	1	0	0
ACSS2	55902	broad.mit.edu	37	20	33509250	33509250	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr20:33509250C>T	ENST00000360596.2	+	11	1606	c.1395C>T	c.(1393-1395)ttC>ttT	p.F465F	ACSS2_ENST00000253382.5_Silent_p.F478F|ACSS2_ENST00000476922.1_Intron|ACSS2_ENST00000336325.4_Silent_p.F415F	NM_018677.3	NP_061147.1	Q9NR19	ACSA_HUMAN	acyl-CoA synthetase short-chain family member 2	465					ethanol oxidation|lipid biosynthetic process|xenobiotic metabolic process	cytosol|nucleus	acetate-CoA ligase activity|ATP binding|protein binding			cervix(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(6)|lung(9)	21					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	TGGACACCTTCTGGCAAACAG	0.572000													23	36					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152328064	152328064	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:152328064C>T	ENST00000388718.5	-	3	2270	c.2198G>A	c.(2197-2199)gGc>gAc	p.G733D	FLG-AS1_ENST00000445097.1_RNA|FLG-AS1_ENST00000392688.2_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	733	Ser-rich.						calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCATGTTGGCCAAAGCTGGA	0.493000													109	2932					0	0	1	0	0
MAP10	54627	broad.mit.edu	37	1	232941206	232941206	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:232941206C>T	ENST00000418460.1	+	1	564	c.437C>T	c.(436-438)tCg>tTg	p.S146L		NM_019090.2	NP_061963.2			microtubule-associated protein 10																		ATGGCGGCCTCGCTGTCCGAG	0.677000													9	14					0	0	1	0	0
JADE2	23338	broad.mit.edu	37	5	133896638	133896638	+	Silent	SNP	T	T	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr5:133896638T>C	ENST00000395003.1	+	6	854	c.675T>C	c.(673-675)tgT>tgC	p.C225C	PHF15_ENST00000361895.2_Silent_p.C225C|PHF15_ENST00000402835.1_Silent_p.C225C|PHF15_ENST00000282605.4_Silent_p.C225C	NM_015288.4	NP_056103.4	Q9NQC1	JADE2_HUMAN		225					histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(6)|prostate(1)|skin(1)	22			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GCAACGTCTGTGTGCATCAGG	0.607000													9	23					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126336276	126336276	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr4:126336276C>T	ENST00000394329.3	+	5	6171	c.6158C>T	c.(6157-6159)tCc>tTc	p.S2053F	FAT4_ENST00000335110.5_Missense_Mutation_p.S351F	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	2053	Cadherin 20.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						ACATTTCTTTCCCCTAAATTG	0.418000													20	75					0	0	1	0	0
TMEM117	84216	broad.mit.edu	37	12	44338099	44338099	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr12:44338099T>G	ENST00000266534.3	+	3	491	c.364T>G	c.(364-366)Ttt>Gtt	p.F122V	TMEM117_ENST00000551577.1_Missense_Mutation_p.F122V|TMEM117_ENST00000536799.1_Missense_Mutation_p.I51S	NM_032256.1	NP_115632.1	Q9H0C3	TM117_HUMAN	transmembrane protein 117	122						endoplasmic reticulum|integral to membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|urinary_tract(1)	23	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.124)		TCTCTTCATATTTTCTCACAT	0.373000													28	47					0	0	1	0	0
ASAP2	8853	broad.mit.edu	37	2	9528444	9528444	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:9528444G>A	ENST00000281419.3	+	22	2492	c.2152G>A	c.(2152-2154)Gac>Aac	p.D718N	ASAP2_ENST00000315273.4_Missense_Mutation_p.D718N|ASAP2_ENST00000491413.1_3'UTR	NM_003887.2	NP_003878.1	O43150	ASAP2_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	718					regulation of ARF GTPase activity	Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|protein binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|lung(15)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	36						CCGGCGGGAAGACCGGCCCAT	0.547000													26	72					0	0	1	0	0
NGLY1	55768	broad.mit.edu	37	3	25778852	25778852	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:25778852C>T	ENST00000428257.1	-	6	1083	c.976G>A	c.(976-978)Gaa>Aaa	p.E326K	NGLY1_ENST00000417874.2_Missense_Mutation_p.E284K|NGLY1_ENST00000396649.3_Missense_Mutation_p.E326K|NGLY1_ENST00000280700.5_Missense_Mutation_p.E326K|NGLY1_ENST00000422724.2_3'UTR	NM_001145293.1	NP_001138765.1	Q96IV0	NGLY1_HUMAN	N-glycanase 1	326					glycoprotein catabolic process	cytoplasm	metal ion binding|peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity|protein binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(7)|prostate(2)|skin(1)	18						TAGCGAGCTTCAAACCCTACA	0.478000													10	21					0	0	1	0	0
LAMTOR2	28956	broad.mit.edu	37	1	156025060	156025060	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:156025060G>A	ENST00000368305.4	+	2	213	c.75G>A	c.(73-75)ctG>ctA	p.L25L	LAMTOR2_ENST00000368302.3_Silent_p.L25L|LAMTOR2_ENST00000489664.1_3'UTR|LAMTOR2_ENST00000368304.5_Silent_p.L25L	NM_014017.3	NP_054736.1	Q9Y2Q5	LTOR2_HUMAN	late endosomal/lysosomal adaptor, MAPK and MTOR activator 2	25					cell growth|cellular protein localization|cellular response to amino acid stimulus|positive regulation of TOR signaling cascade	lysosomal membrane|Ragulator complex				breast(1)|cervix(1)|kidney(1)|large_intestine(1)|lung(2)|skin(1)	7						CCAGGCTGCTGAATAACGAGG	0.612000													37	177					0	0	1	0	0
CDC123	8872	broad.mit.edu	37	10	12257760	12257760	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr10:12257760G>A	ENST00000281141.4	+	5	539	c.259G>A	c.(259-261)Gcc>Acc	p.A87T	CDC123_ENST00000455773.3_3'UTR|CDC123_ENST00000378900.2_Missense_Mutation_p.A87T	NM_006023.2	NP_006014.2	O75794	CD123_HUMAN	cell division cycle 123	87					cell cycle arrest|cell division|positive regulation of cell proliferation|regulation of mitotic cell cycle	cytoplasm				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	12						TCCTGAGTTTGCCACTAAAGT	0.408000													14	47					0	0	1	0	0
KRT10	3858	broad.mit.edu	37	17	38975803	38975803	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr17:38975803G>A	ENST00000269576.5	-	6	1348	c.1339C>T	c.(1339-1341)Caa>Taa	p.Q447*	TMEM99_ENST00000496847.1_Intron|TMEM99_ENST00000301665.3_Intron	NM_000421.3	NP_000412	P13645	K1C10_HUMAN	keratin 10	447	Coil 2.|Gly-rich.|Rod.				epidermis development		protein binding|structural constituent of epidermis			NS(2)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)	11		Breast(137;0.000301)				CGGTAGGTTTGAATTTCATTC	0.398000													22	77					0	0	1	0	0
ZNF189	7743	broad.mit.edu	37	9	104171253	104171253	+	Silent	SNP	A	A	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr9:104171253A>G	ENST00000374861.3	+	3	1445	c.1161A>G	c.(1159-1161)aaA>aaG	p.K387K	ZNF189_ENST00000339664.2_Silent_p.K401K|ZNF189_ENST00000259395.4_Silent_p.K359K	NM_001278231.1|NM_001278232.1|NM_003452.2	NP_001265160.1|NP_001265161.1|NP_003443.2	O75820	ZN189_HUMAN	zinc finger protein 189	401					negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(10)|ovary(2)|prostate(3)|skin(2)|urinary_tract(1)	26		Acute lymphoblastic leukemia(62;0.0559)				AGCCCCATAAATGTGAGGAAT	0.423000													14	44					0	0	1	0	0
ZNF396	252884	broad.mit.edu	37	18	32954038	32954038	+	Silent	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr18:32954038G>C	ENST00000306346.1	-	2	350	c.219C>G	c.(217-219)ctC>ctG	p.L73L	ZNF396_ENST00000586687.1_Silent_p.L73L|ZNF396_ENST00000589332.1_Silent_p.L73L	NM_145756.2	NP_665699.1	Q96N95	ZN396_HUMAN	zinc finger protein 396	73	SCAN box.				viral reproduction	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|pancreas(1)	7						AAAGTTCCCAGAGCCGGCTCA	0.597000													31	62					0	0	1	0	0
C5orf34	375444	broad.mit.edu	37	5	43506427	43506427	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr5:43506427C>T	ENST00000306862.2	-	4	730	c.355G>A	c.(355-357)Gag>Aag	p.E119K	RP11-159F24.3_ENST00000505645.1_RNA	NM_198566.2	NP_940968	Q96MH7	CE034_HUMAN	chromosome 5 open reading frame 34	119										breast(2)|endometrium(2)|large_intestine(2)|lung(11)|ovary(1)|prostate(1)|stomach(2)	21	Lung NSC(6;2.07e-05)					ATGCCACTCTCCATATATATC	0.413000													20	24					0	0	1	0	0
ZDHHC21	340481	broad.mit.edu	37	9	14674302	14674302	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr9:14674302C>A	ENST00000380916.4	-	4	503	c.37G>T	c.(37-39)Ggt>Tgt	p.G13C		NM_178566.4	NP_848661.1	Q8IVQ6	ZDH21_HUMAN	zinc finger, DHHC-type containing 21						nitric oxide metabolic process|regulation of nitric-oxide synthase activity	Golgi membrane|integral to membrane	palmitoyltransferase activity|zinc ion binding			endometrium(2)|large_intestine(4)|lung(2)|skin(1)	9				GBM - Glioblastoma multiforme(50;4.31e-06)		CAGCACCAACCATGTGGGTCA	0.403000													29	154					6.38683e-12	6.78733e-12	1	1	0
WDR13	64743	broad.mit.edu	37	X	48460562	48460562	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chrX:48460562C>T	ENST00000218056.5	+	7	1627	c.1122C>T	c.(1120-1122)atC>atT	p.I374I	WDR13_ENST00000376729.5_Silent_p.I374I	NM_001166426.1|NM_017883.4	NP_001159898.1|NP_060353	Q9H1Z4	WDR13_HUMAN	WD repeat domain 13	374						cytoplasm|nucleus				endometrium(1)|large_intestine(4)|lung(4)|ovary(2)	11						CACTGCTCATCAATGCTTGCC	0.627000													14	27					0	0	1	0	0
GLIS3	169792	broad.mit.edu	37	9	4125841	4125841	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr9:4125841G>A	ENST00000324333.10	-	2	217	c.24C>T	c.(22-24)ctC>ctT	p.L8L	GLIS3_ENST00000381971.3_Silent_p.L163L	NM_152629.3	NP_689842.3	Q8NEA6	GLIS3_HUMAN	GLIS family zinc finger 3	8					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(12)|lung(4)|ovary(2)|prostate(1)|skin(1)	26		Acute lymphoblastic leukemia(2;0.00464)|Breast(48;0.148)		Lung(2;0.00163)|GBM - Glioblastoma multiforme(50;0.00301)|LUSC - Lung squamous cell carcinoma(2;0.0148)		GAGGTGAAATGAGTCCCAGTC	0.522000													22	149					0	0	1	0	0
THAP9	79725	broad.mit.edu	37	4	83825922	83825922	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr4:83825922G>C	ENST00000302236.5	+	2	165	c.114G>C	c.(112-114)tgG>tgC	p.W38C		NM_024672.4	NP_078948.3	Q9H5L6	THAP9_HUMAN	THAP domain containing 9	38							DNA binding|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(13)|lung(5)|ovary(2)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(3)	33		Hepatocellular(203;0.114)				GCTCAAAATGGATCAGGGCTG	0.363000													19	39					0	0	1	0	0
EVC2	132884	broad.mit.edu	37	4	5699372	5699372	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr4:5699372G>T	ENST00000344408.5	-	2	284	c.231C>A	c.(229-231)gaC>gaA	p.D77E	EVC2_ENST00000310917.2_5'UTR|EVC2_ENST00000344938.1_Missense_Mutation_p.D77E	NM_147127.4	NP_667338.3	Q86UK5	LBN_HUMAN	Ellis van Creveld syndrome 2	77						integral to membrane				NS(2)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(32)|lung(28)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	81						TACAGGGCAAGTCCTAAAAAA	0.378000													6	20					3.09899e-07	3.23985e-07	1	1	0
VAV2	7410	broad.mit.edu	37	9	136671208	136671208	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr9:136671208C>T	ENST00000371851.1	-	8	1141	c.816G>A	c.(814-816)aaG>aaA	p.K272K	VAV2_ENST00000406606.3_Silent_p.K272K|VAV2_ENST00000371850.3_Silent_p.K277K			P52735	VAV2_HUMAN	vav 2 guanine nucleotide exchange factor	277	DH.				angiogenesis|apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	metal ion binding|Rho guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(3)|endometrium(1)|kidney(3)|large_intestine(5)|lung(13)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(1)	35				OV - Ovarian serous cystadenocarcinoma(145;3.9e-07)|Epithelial(140;2.07e-06)|all cancers(34;9.39e-06)		CTCACCTTTCCTTGAAATCGA	0.602000													3	17					0	0	1	0	0
PCDHGA1	56114	broad.mit.edu	37	5	140711111	140711111	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr5:140711111G>C	ENST00000517417.1	+	1	860	c.860G>C	c.(859-861)aGa>aCa	p.R287T	PCDHGA1_ENST00000378105.3_Missense_Mutation_p.R287T	NM_018912.2	NP_061735.1														breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|lung(32)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTAGACCACAGAGTGGCCCAA	0.418000													23	43					0	0	1	0	0
KLHL1	57626	broad.mit.edu	37	13	70681804	70681804	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr13:70681804C>T	ENST00000377844.4	-	1	787	c.28G>A	c.(28-30)Gat>Aat	p.D10N	ATXN8OS_ENST00000414504.2_RNA|KLHL1_ENST00000545028.1_5'UTR	NM_020866.2	NP_065917.1	Q9NR64	KLHL1_HUMAN	kelch-like family member 1	10					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding	p.D10N(1)		breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(56)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	84		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		TGCTTCACATCGAAGTCTTTT	0.627000													4	15					0	0	1	0	0
SWT1	54823	broad.mit.edu	37	1	185159688	185159688	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:185159688G>C	ENST00000367500.4	+	10	1602	c.1437G>C	c.(1435-1437)ttG>ttC	p.L479F	SWT1_ENST00000367501.3_Missense_Mutation_p.L479F	NM_017673.6	NP_060143.4	Q5T5J6	SWT1_HUMAN	SWT1 RNA endoribonuclease homolog (S. cerevisiae)	479	PINc.									breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(16)|ovary(1)|prostate(1)|urinary_tract(1)	41						CAGATGGATTGAGTGATGAGA	0.363000													7	33					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189871168	189871168	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:189871168G>A	ENST00000304636.3	+	43	3361	c.3191G>A	c.(3190-3192)aGa>aAa	p.R1064K	COL3A1_ENST00000317840.5_Intron	NM_000090.3	NP_000081	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	1064	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	AGTGGTGACAGAGGAGAAAGT	0.507000													7	29					0	0	1	0	0
ZNF814	730051	broad.mit.edu	37	19	58385546	58385546	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:58385546G>T	ENST00000435989.2	-	3	1446	c.1212C>A	c.(1210-1212)gaC>gaA	p.D404E	ZNF814_ENST00000597832.1_Intron|ZNF814_ENST00000595295.1_Intron|ZNF814_ENST00000597342.1_Intron|ZNF814_ENST00000600634.1_Intron|ZNF814_ENST00000596604.1_Intron	NM_001144989.1	NP_001138461.1	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	404					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding	p.D404E(10)		NS(1)|central_nervous_system(2)|endometrium(3)|kidney(9)|lung(2)|prostate(4)|skin(1)|urinary_tract(3)	25						AATGTTTTTTGTCAGTGTGAA	0.393000													3	14					0.004672	0.00472581	1	1	0
SOS1	6654	broad.mit.edu	37	2	39240676	39240676	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:39240676C>T	ENST00000426016.1	-	14	2178	c.2092G>A	c.(2092-2094)Gag>Aag	p.E698K	SOS1_ENST00000402219.2_Missense_Mutation_p.E698K|SOS1_ENST00000395038.2_Missense_Mutation_p.E698K			Q07889	SOS1_HUMAN	son of sevenless homolog 1 (Drosophila)	698	N-terminal Ras-GEF.				apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|liver(1)|lung(29)|ovary(4)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	75		all_hematologic(82;0.21)				AAGTGGTGCTCTACCCAGTGC	0.333000									Noonan syndrome				22	95					0	0	1	0	0
C1orf43	25912	broad.mit.edu	37	1	154184941	154184941	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:154184941C>T	ENST00000368521.5	-	5	698	c.500G>A	c.(499-501)gGg>gAg	p.G167E	C1orf43_ENST00000368516.1_Missense_Mutation_p.G133E|C1orf43_ENST00000368518.1_Missense_Mutation_p.G167E|C1orf43_ENST00000350592.3_Missense_Mutation_p.G133E|C1orf43_ENST00000362076.4_Missense_Mutation_p.G115E|C1orf43_ENST00000368519.1_Missense_Mutation_p.G149E	NM_001098616.1	NP_001092086.1	Q9BWL3	CA043_HUMAN	chromosome 1 open reading frame 43	167						integral to membrane	coenzyme binding|oxidoreductase activity			cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(3)|ovary(1)	10	all_lung(78;1.98e-30)|Lung NSC(65;2.87e-28)|Hepatocellular(266;0.0877)					TACCCCTGTCCCATAGCGGGC	0.488000													31	113					0	0	1	0	0
OR10G8	219869	broad.mit.edu	37	11	123900584	123900584	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr11:123900584C>T	ENST00000431524.1	+	1	288	c.255C>T	c.(253-255)ttC>ttT	p.F85F		NM_001004464.1	NP_001004464.1	Q8NGN5	O10G8_HUMAN	olfactory receptor, family 10, subfamily G, member 8	85					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(7)|large_intestine(2)|lung(21)|ovary(1)|prostate(5)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	44		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		CTTTGGTGTTCCCAAGTGGCA	0.517000													52	117					0	0	1	0	0
BTBD8	284697	broad.mit.edu	37	1	92554305	92554305	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:92554305C>T	ENST00000370382.3	+	2	467	c.200C>T	c.(199-201)aCt>aTt	p.T67I	BTBD8_ENST00000540648.1_Missense_Mutation_p.T67I|BTBD8_ENST00000342818.3_Missense_Mutation_p.T67I			Q5XKL5	BTBD8_HUMAN	BTB (POZ) domain containing 8	67	BTB 1.					nucleus				breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(8)|ovary(1)	16		all_lung(203;0.0484)|Lung NSC(277;0.126)|Glioma(108;0.222)		all cancers(265;0.0153)|Epithelial(280;0.0982)		GTGGGTTGTACTTTGTTCAAA	0.348000													7	38					0	0	1	0	0
CCDC28A	25901	broad.mit.edu	37	6	139100964	139100964	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr6:139100964T>A	ENST00000332797.6	+	3	589	c.434T>A	c.(433-435)aTg>aAg	p.M145K		NM_015439.2	NP_056254.1	Q8IWP9	CC28A_HUMAN	coiled-coil domain containing 28A	145										autonomic_ganglia(1)|large_intestine(3)|lung(8)|ovary(1)	13				OV - Ovarian serous cystadenocarcinoma(155;0.000201)|GBM - Glioblastoma multiforme(68;0.000306)		TACAGAGTGATGAAAGAAAAG	0.408000													32	32					0	0	1	0	0
SETD4	54093	broad.mit.edu	37	21	37410507	37410507	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr21:37410507C>A	ENST00000399215.1	-	9	2501	c.1129G>T	c.(1129-1131)Gac>Tac	p.D377Y	SETD4_ENST00000399212.1_Missense_Mutation_p.D353Y|SETD4_ENST00000332131.4_Missense_Mutation_p.D377Y|SETD4_ENST00000481477.1_5'UTR|AP000688.1_ENST00000600312.1_Intron			Q9NVD3	SETD4_HUMAN	SET domain containing 4	377				EILVKYLPSTDKQMDKKISILKDHGYIENLTFGWDGPSWRL LTALKLLCLEAEKFTCWKKVLLGEVISDTNEKTSLDIAQKI CYYFIEETNAVLQKVSHMKDEKEALINQLTLVESLWTEELK ILRASAETLHSLQTAFT -> GWNQLCS (in Ref. 5; AAH02898).						autonomic_ganglia(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)	15						TGGGCTATGTCCAAACTTGTC	0.353000													30	43					3.65163e-15	3.91072e-15	1	1	0
CAMTA1	23261	broad.mit.edu	37	1	7826544	7826544	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:7826544G>T	ENST00000439411.2	+	22	4942	c.4942G>T	c.(4942-4944)Gaa>Taa	p.E1648*	CAMTA1_ENST00000303635.7_Missense_Mutation_p.G1672V|CAMTA1_ENST00000476864.1_Nonsense_Mutation_p.E226*			Q9Y6Y1	CMTA1_HUMAN	calmodulin binding transcription activator 1	0					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(11)|lung(29)|ovary(5)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	85	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		AAAGGCCAAGGAACTTGAAGA	0.388000			T	WWTR1	epitheliod hemangioendothelioma								12	31					0.00185496	0.00188224	1	1	0
INO80D	54891	broad.mit.edu	37	2	206921045	206921045	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:206921045C>T	ENST00000403263.1	-	4	1245	c.841G>A	c.(841-843)Gac>Aac	p.D281N		NM_017759.4	NP_060229.3	Q53TQ3	IN80D_HUMAN	INO80 complex subunit D	281					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|cervix(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(9)|ovary(2)|prostate(1)|urinary_tract(2)	26						AGGATCCGGTCAGTCCTGGGT	0.552000													15	40					0	0	1	0	0
C3orf20	84077	broad.mit.edu	37	3	14746120	14746120	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:14746120C>T	ENST00000253697.3	+	7	1607	c.1155C>T	c.(1153-1155)ttC>ttT	p.F385F	C3orf20_ENST00000495387.1_3'UTR|C3orf20_ENST00000435614.1_Silent_p.F263F|C3orf20_ENST00000412910.1_Silent_p.F263F	NM_032137.4	NP_115513.4	Q8ND61	CC020_HUMAN	chromosome 3 open reading frame 20	385						cytoplasm|integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(13)|lung(11)|ovary(4)|skin(2)	40						GCTCCTCCTTCGTTTAGTATC	0.463000													22	127					0	0	1	0	0
ABCC12	94160	broad.mit.edu	37	16	48138202	48138202	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr16:48138202G>T	ENST00000311303.3	-	20	3096	c.2751C>A	c.(2749-2751)gaC>gaA	p.D917E	ABCC12_ENST00000416054.1_3'UTR|ABCC12_ENST00000448542.1_Intron	NM_033226.2	NP_150229.2	Q96J65	MRP9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 12	917	ABC transmembrane type-1 2.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|liver(1)|lung(43)|ovary(2)|prostate(3)|skin(7)|urinary_tract(1)	90		all_cancers(37;0.0474)|all_lung(18;0.047)				CATCCAGCTCGTCCATATCCT	0.473000													55	47					9.53978e-28	1.03312e-27	1	1	0
EIF2B5	8893	broad.mit.edu	37	3	183855689	183855689	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:183855689G>C	ENST00000273783.3	+	4	632	c.510G>C	c.(508-510)ttG>ttC	p.L170F	EIF2B5_ENST00000498831.1_3'UTR|EIF2B5_ENST00000444495.1_Missense_Mutation_p.L170F	NM_003907.2	NP_003898.2	Q13144	EI2BE_HUMAN	eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa	170					astrocyte development|myelination|negative regulation of translational initiation in response to stress|oligodendrocyte development|ovarian follicle development|positive regulation of translational initiation|response to glucose stimulus|response to heat|response to peptide hormone stimulus|RNA metabolic process	cytosol|eukaryotic translation initiation factor 2B complex|nucleus	guanyl-nucleotide exchange factor activity|transferase activity|translation initiation factor activity|translation initiation factor binding			cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(9)|ovary(5)|urinary_tract(1)	27	all_cancers(143;7.59e-11)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			TTTATAGGTTGAGACGGAAGC	0.483000													23	54					0	0	1	0	0
NRSN1	140767	broad.mit.edu	37	6	24145795	24145795	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr6:24145795C>T	ENST00000378491.4	+	4	510	c.209C>T	c.(208-210)aCa>aTa	p.T70I		NM_080723.4	NP_542454.3	Q8IZ57	NRSN1_HUMAN	neurensin 1	70					nervous system development	growth cone|integral to membrane|neuronal cell body|transport vesicle				breast(1)|endometrium(2)|large_intestine(2)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	22						ATCTCAGGTACAGTTTTTGTG	0.517000													28	144					0	0	1	0	0
ALX1	8092	broad.mit.edu	37	12	85694985	85694985	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr12:85694985C>T	ENST00000316824.3	+	4	868	c.713C>T	c.(712-714)tCa>tTa	p.S238L		NM_006982.2	NP_008913.2	Q15699	ALX1_HUMAN	ALX homeobox 1	238					brain development|cartilage condensation|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		sequence-specific DNA binding transcription factor activity|transcription corepressor activity			breast(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(16)|ovary(1)	26				GBM - Glioblastoma multiforme(134;0.134)		GTGGTTACTTCATGCATGTTA	0.413000													26	105					0	0	1	0	0
PRCP	5547	broad.mit.edu	37	11	82550305	82550305	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr11:82550305G>C	ENST00000313010.3	-	7	1278	c.1084C>G	c.(1084-1086)Cag>Gag	p.Q362E	PRCP_ENST00000393399.2_Missense_Mutation_p.Q383E|PRCP_ENST00000535099.1_Missense_Mutation_p.Q257E|PRCP_ENST00000525772.1_5'UTR	NM_005040.2	NP_005031.1	P42785	PCP_HUMAN	prolylcarboxypeptidase (angiotensinase C)	362					blood coagulation, intrinsic pathway|proteolysis	lysosome|plasma membrane	protein binding|serine-type carboxypeptidase activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(7)|prostate(1)|skin(2)|urinary_tract(1)	17						ATATTTACCTGATAGCTCCAA	0.398000													17	40					0	0	1	0	0
E2F8	79733	broad.mit.edu	37	11	19251237	19251237	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr11:19251237T>G	ENST00000527884.1	-	10	1889	c.1657A>C	c.(1657-1659)Act>Cct	p.T553P	E2F8_ENST00000250024.4_Missense_Mutation_p.T553P|RP11-428C19.4_ENST00000527978.1_RNA	NM_001256371.1|NM_001256372.1	NP_001243300.1|NP_001243301.1	A0AVK6	E2F8_HUMAN	E2F transcription factor 8	553					cell cycle	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						TTTGAGCCAGTAGCTTTAGAA	0.572000													30	69					0	0	1	0	0
MAP2K2	5605	broad.mit.edu	37	19	4117548	4117548	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:4117548G>C	ENST00000262948.5	-	2	425	c.172C>G	c.(172-174)Ctc>Gtc	p.L58V	MAP2K2_ENST00000394867.4_5'UTR|MAP2K2_ENST00000599345.1_5'UTR	NM_030662.3	NP_109587.1	P36507	MP2K2_HUMAN	mitogen-activated protein kinase kinase 2	58					activation of MAPK activity|activation of MAPKK activity|axon guidance|epidermal growth factor receptor signaling pathway|ERK1 and ERK2 cascade|innate immune response|insulin receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|extracellular region	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity						Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		TTCTGGGTGAGAAAGGCTTCC	0.592000													31	53					0	0	1	0	0
RNF213	57674	broad.mit.edu	37	17	78321919	78321919	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr17:78321919G>A	ENST00000582970.1	+	29	9927	c.9784G>A	c.(9784-9786)Gct>Act	p.A3262T	RNF213_ENST00000508628.2_Missense_Mutation_p.A3311T|RNF213_ENST00000336301.6_Missense_Mutation_p.A1335T	NM_001256071.1	NP_001243000.1	Q9HCF4	ALO17_HUMAN	ring finger protein 213	0										NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	130	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			GCTGAACTGCGCTACGCCCGA	0.622000													17	57					0	0	1	0	0
NOL8	55035	broad.mit.edu	37	9	95076684	95076684	+	Silent	SNP	A	A	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr9:95076684A>G	ENST00000545558.1	-	7	2715	c.2223T>C	c.(2221-2223)tcT>tcC	p.S741S	NOL8_ENST00000542053.1_Silent_p.S673S|NOL8_ENST00000535387.1_Silent_p.S741S|NOL8_ENST00000442668.2_Silent_p.S741S|NOL8_ENST00000358855.4_Silent_p.S673S			Q76FK4	NOL8_HUMAN	nucleolar protein 8	741					DNA replication|positive regulation of cell growth	nucleolus	nucleotide binding|protein binding|RNA binding			endometrium(3)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)	16						AATTACTAATAGAAAGTGAGA	0.443000													16	54					0	0	1	0	0
PDK3	5165	broad.mit.edu	37	X	24512899	24512899	+	Silent	SNP	A	A	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chrX:24512899A>G	ENST00000441463.2	+	2	147	c.147A>G	c.(145-147)ctA>ctG	p.L49L	PDK3_ENST00000379162.4_Silent_p.L49L|PDK3_ENST00000493226.1_3'UTR	NM_001142386.2	NP_001135858.1	Q15120	PDK3_HUMAN	pyruvate dehydrogenase kinase, isozyme 3	49					glucose metabolic process|peptidyl-histidine phosphorylation|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	ATP binding|protein binding|pyruvate dehydrogenase (acetyl-transferring) kinase activity|two-component sensor activity			NS(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	23						ATATGTTTCTACGAAAGGAAC	0.378000													17	14					0	0	1	0	0
TTI2	80185	broad.mit.edu	37	8	33369543	33369543	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr8:33369543C>T	ENST00000431156.2	-	2	1207	c.589G>A	c.(589-591)Gaa>Aaa	p.E197K	TTI2_ENST00000360742.5_Missense_Mutation_p.E197K|TTI2_ENST00000520636.1_Missense_Mutation_p.E197K	NM_001102401.2	NP_001095871.1	Q6NXR4	CH041_HUMAN	TELO2 interacting protein 2	197							binding										TTCTCATCTTCATTTTCTCCA	0.502000													52	64					0	0	1	0	0
FURIN	5045	broad.mit.edu	37	15	91423993	91423993	+	Silent	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr15:91423993C>G	ENST00000268171.3	+	14	1908	c.1629C>G	c.(1627-1629)ccC>ccG	p.P543P		NM_002569.2	NP_002560.1	P09958	FURIN_HUMAN	furin (paired basic amino acid cleaving enzyme)	543					cell proliferation|negative regulation of low-density lipoprotein particle receptor catabolic process|negative regulation of transforming growth factor-beta1 production|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|Notch signaling pathway|peptide biosynthetic process|peptidyl-glutamic acid carboxylation|post-translational protein modification|secretion by cell|signal peptide processing|transforming growth factor beta receptor signaling pathway|viral assembly, maturation, egress, and release	cell surface|Golgi lumen|Golgi membrane|integral to membrane|membrane raft|plasma membrane|trans-Golgi network|trans-Golgi network transport vesicle	metal ion binding|nerve growth factor binding|peptide binding|protease binding|serine-type endopeptidase activity|serine-type endopeptidase inhibitor activity			breast(1)|central_nervous_system(4)|endometrium(4)|large_intestine(3)|liver(2)|lung(13)|ovary(2)|prostate(3)|skin(1)|urinary_tract(3)	36	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			ATGAGGATCCCTCTGGCGAGT	0.572000													12	28					0	0	1	0	0
IKBIP	121457	broad.mit.edu	37	12	99020532	99020532	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr12:99020532C>T	ENST00000299157.4	-	3	683	c.310G>A	c.(310-312)Gaa>Aaa	p.E104K	IKBIP_ENST00000420861.1_Intron|IKBIP_ENST00000393042.3_Intron|IKBIP_ENST00000342502.2_Intron	NM_153687.3	NP_710154.1	Q70UQ0	IKIP_HUMAN	IKBKB interacting protein	104					induction of apoptosis|response to X-ray	endoplasmic reticulum membrane|integral to membrane	protein binding			NS(1)|kidney(1)|large_intestine(1)|lung(1)|prostate(2)	6						AGGATGCTTTCAGTAGACTCA	0.368000													11	52					0	0	1	0	0
BSN	8927	broad.mit.edu	37	3	49662566	49662566	+	Missense_Mutation	SNP	C	C	T	rs140421176	byFrequency	TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:49662566C>T	ENST00000296452.4	+	2	497	c.383C>T	c.(382-384)aCg>aTg	p.T128M		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	128					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		CCCCGCAGGACGCTGCAGGTA	0.642000													5	36					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9088890	9088890	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:9088890C>A	ENST00000397910.4	-	1	3128	c.2925G>T	c.(2923-2925)aaG>aaT	p.K975N		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	975	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTAACCCTGTCTTGAATCTGG	0.473000													109	129					5.58122e-63	6.10584e-63	1	1	0
OBSCN	84033	broad.mit.edu	37	1	228412242	228412242	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:228412242C>T	ENST00000570156.2	+	10	3086	c.3012C>T	c.(3010-3012)tgC>tgT	p.C1004C	OBSCN_ENST00000366707.4_5'UTR|OBSCN_ENST00000422127.1_Silent_p.C912C|OBSCN_ENST00000366709.4_5'UTR|OBSCN_ENST00000284548.11_Silent_p.C912C	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	1004	Ig-like 10.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				CACTGAGCTGCGAGGTGGCCC	0.627000													17	56					0	0	1	0	0
LPHN2	23266	broad.mit.edu	37	1	82434932	82434932	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:82434932G>C	ENST00000370728.1	+	17	3227	c.2582G>C	c.(2581-2583)tGc>tCc	p.C861S	LPHN2_ENST00000370721.1_Missense_Mutation_p.C786S|LPHN2_ENST00000370730.1_Missense_Mutation_p.C861S|LPHN2_ENST00000370717.2_Missense_Mutation_p.C861S|LPHN2_ENST00000370715.1_Missense_Mutation_p.C848S|LPHN2_ENST00000359929.3_Missense_Mutation_p.C848S|LPHN2_ENST00000335786.5_Missense_Mutation_p.C861S|LPHN2_ENST00000469377.2_Intron|LPHN2_ENST00000370727.1_Missense_Mutation_p.C861S|LPHN2_ENST00000271029.4_Missense_Mutation_p.C861S|LPHN2_ENST00000370725.1_Missense_Mutation_p.C861S|LPHN2_ENST00000394879.1_Missense_Mutation_p.C848S|LPHN2_ENST00000370713.1_Missense_Mutation_p.C848S|LPHN2_ENST00000370723.1_Missense_Mutation_p.C848S|LPHN2_ENST00000319517.6_Missense_Mutation_p.C848S			O95490	LPHN2_HUMAN	latrophilin 2	861					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			NS(3)|breast(6)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(37)|ovary(3)|pancreas(1)|prostate(3)|skin(22)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	119				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		TCCCTTGTTTGCCTGGCTATC	0.393000													35	76					0	0	1	0	0
GREB1	9687	broad.mit.edu	37	2	11735506	11735506	+	Splice_Site	SNP	G	G	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:11735506G>T	ENST00000381486.2	+	12	2125		c.e12+1		GREB1_ENST00000234142.5_Splice_Site	NM_014668.3	NP_055483.2	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1							integral to membrane				breast(3)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)	30	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		CTCTGTCCAGGTAGGCTTGTC	0.552000													12	44					5.50884e-06	5.71594e-06	1	1	0
OR8B2	26595	broad.mit.edu	37	11	124252488	124252488	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr11:124252488A>T	ENST00000375013.2	-	1	770	c.752T>A	c.(751-753)tTt>tAt	p.F251Y		NM_001005468.1	NP_001005468.1	Q96RD0	OR8B2_HUMAN	olfactory receptor, family 8, subfamily B, member 2	251					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(13)|ovary(1)	23		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		TGACCCAAAAAACAGAGACAG	0.388000													32	41					0	0	1	0	0
TRBJ2-5	28624	broad.mit.edu	37	7	142494822	142494822	+	RNA	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr7:142494822C>T	ENST00000390417.1	+	0	20																											CCCAGTACTTCGGGCCAGGCA	0.726000													14	21					0	0	1	0	0
ARID5A	10865	broad.mit.edu	37	2	97213236	97213236	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:97213236G>A	ENST00000357485.3	+	2	180	c.102G>A	c.(100-102)caG>caA	p.Q34Q	ARID5A_ENST00000454558.2_5'UTR	NM_212481.1	NP_997646.1	Q03989	ARI5A_HUMAN	AT rich interactive domain 5A (MRF1-like)	34					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(2)|skin(1)|urinary_tract(2)	14						ACGGAATCCAGAACCCCATCT	0.622000													9	32					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126371115	126371115	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr4:126371115C>G	ENST00000394329.3	+	9	8957	c.8944C>G	c.(8944-8946)Caa>Gaa	p.Q2982E	FAT4_ENST00000335110.5_Missense_Mutation_p.Q1280E	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	2982	Cadherin 28.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						CAATGCACCTCAATTTCTTAA	0.343000													12	22					0	0	1	0	0
PSORS1C1	170679	broad.mit.edu	37	6	31106554	31106554	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr6:31106554C>T	ENST00000259881.9	+	5	454	c.165C>T	c.(163-165)ttC>ttT	p.F55F	PSORS1C2_ENST00000259845.4_Intron|PSORS1C1_ENST00000547221.1_Silent_p.F7F|PSORS1C1_ENST00000481450.2_Intron	NM_014068.2	NP_054787.2	Q9UIG5	PS1C1_HUMAN	psoriasis susceptibility 1 candidate 1	55										kidney(1)|ovary(2)|prostate(1)|skin(1)	5						CAAACCATTTCTGGTGAGAGC	0.547000													116	75					0	0	1	0	0
COG7	91949	broad.mit.edu	37	16	23453807	23453807	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr16:23453807G>A	ENST00000307149.5	-	4	780	c.595C>T	c.(595-597)Cag>Tag	p.Q199*		NM_153603.3	NP_705831.1	P83436	COG7_HUMAN	component of oligomeric golgi complex 7	199					intracellular protein transport|protein glycosylation|protein localization in Golgi apparatus|protein stabilization|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding			breast(1)|central_nervous_system(1)|endometrium(7)|large_intestine(9)|liver(1)|lung(7)|urinary_tract(1)	27				GBM - Glioblastoma multiforme(48;0.0401)		CCTACAGCCTGAGAGGTGAAT	0.458000													24	136					0	0	1	0	0
PAXIP1	22976	broad.mit.edu	37	7	154767729	154767729	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr7:154767729C>T	ENST00000404141.1	-	6	905	c.751G>A	c.(751-753)Gat>Aat	p.D251N	PAXIP1_ENST00000397192.1_Missense_Mutation_p.D251N|PAXIP1_ENST00000473219.1_5'UTR			Q6ZW49	PAXI1_HUMAN	PAX interacting (with transcription-activation domain) protein 1	251					DNA damage response, signal transduction by p53 class mediator|DNA recombination|DNA repair|histone H3-K4 methylation|positive regulation of histone acetylation|positive regulation of histone H3-K36 methylation|positive regulation of histone H3-K4 methylation|positive regulation of isotype switching|positive regulation of protein ubiquitination|positive regulation of transcription initiation from RNA polymerase II promoter|response to ionizing radiation|transcription, DNA-dependent	histone methyltransferase complex|nuclear matrix				NS(1)|breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	33	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0296)	UCEC - Uterine corpus endometrioid carcinoma (81;0.178)		TCTGAAGAATCATCAAACATT	0.478000													3	6					0	0	1	0	0
TRPM3	80036	broad.mit.edu	37	9	73426110	73426110	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr9:73426110C>T	ENST00000377106.1	-	7	919	c.565G>A	c.(565-567)Ggt>Agt	p.G189S	TRPM3_ENST00000377111.2_Intron|TRPM3_ENST00000361823.5_Intron|TRPM3_ENST00000396292.4_Missense_Mutation_p.G189S|TRPM3_ENST00000360823.2_Missense_Mutation_p.G189S|TRPM3_ENST00000358082.3_Missense_Mutation_p.G189S|TRPM3_ENST00000423814.3_Missense_Mutation_p.G344S|TRPM3_ENST00000377101.1_Intron|TRPM3_ENST00000408909.2_Intron|TRPM3_ENST00000396280.5_Intron|TRPM3_ENST00000396285.1_Intron|TRPM3_ENST00000357533.2_Intron|TRPM3_ENST00000377110.3_Intron|TRPM3_ENST00000377105.1_Intron|TRPM3_ENST00000396283.1_Missense_Mutation_p.G189S	NM_020952.4|NM_206946.3	NP_066003.3|NP_996829.3	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel, subfamily M, member 3	342						integral to membrane	calcium channel activity	p.G189C(1)		NS(2)|breast(4)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(18)|liver(1)|lung(46)|ovary(3)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(1)	95						TGGCAACTACCCCAAAATGAA	0.353000													3	9					0	0	1	0	0
RGR	5995	broad.mit.edu	37	10	86017692	86017692	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr10:86017692G>A	ENST00000359452.4	+	6	724	c.686G>A	c.(685-687)gGc>gAc	p.G229D	RGR_ENST00000479725.1_3'UTR|RGR_ENST00000358110.5_Intron	NM_001012720.1|NM_002921.3	NP_001012738.1|NP_002912.2	P47804	RGR_HUMAN	retinal G protein coupled receptor	225					phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity|protein binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|stomach(1)	17						CTCGGCTGGGGCCCCTATGCC	0.532000													11	28					0	0	1	0	0
DHRS4L1	728635	broad.mit.edu	37	14	24505784	24505784	+	RNA	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr14:24505784C>T	ENST00000558293.1	+	0	123					NR_102693.1																						CCGGGATGACCCGCCGGGACC	0.647000													14	5					0	0	1	0	0
P4HB	5034	broad.mit.edu	37	17	79813377	79813377	+	Silent	SNP	T	T	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr17:79813377T>C	ENST00000331483.4	-	3	660	c.438A>G	c.(436-438)gcA>gcG	p.A146A	P4HB_ENST00000576390.1_Intron|P4HB_ENST00000439918.2_Intron|P4HB_ENST00000472244.1_5'UTR	NM_000918.3	NP_000909.2	P07237	PDIA1_HUMAN	prolyl 4-hydroxylase, beta polypeptide	146					cell redox homeostasis|glycerol ether metabolic process|lipid metabolic process|lipoprotein metabolic process|peptidyl-proline hydroxylation to 4-hydroxy-L-proline	cell surface|endoplasmic reticulum lumen|ER-Golgi intermediate compartment|extracellular region|melanosome|plasma membrane	electron carrier activity|procollagen-proline 4-dioxygenase activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			NS(1)|breast(1)|large_intestine(2)|lung(17)|urinary_tract(1)	22	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.013)|OV - Ovarian serous cystadenocarcinoma(97;0.0509)			CCAAGGACTCTGCAGCTGCGC	0.587000													34	38					0	0	1	0	0
SLC5A1	6523	broad.mit.edu	37	22	32506042	32506042	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr22:32506042G>C	ENST00000266088.4	+	15	2087	c.1837G>C	c.(1837-1839)Gag>Cag	p.E613Q	SLC5A1_ENST00000543737.1_Missense_Mutation_p.E486Q	NM_000343.3	NP_000334.1	P13866	SC5A1_HUMAN	solute carrier family 5 (sodium/glucose cotransporter), member 1	613					carbohydrate metabolic process	integral to plasma membrane	glucose:sodium symporter activity|protein binding			NS(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(1)|prostate(2)|skin(4)|urinary_tract(1)	37						TTGTGGGCTAGAGCAGCACGG	0.463000													13	47					0	0	1	0	0
SMPD3	55512	broad.mit.edu	37	16	68398693	68398693	+	Missense_Mutation	SNP	C	C	T	rs141206967	byFrequency	TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr16:68398693C>T	ENST00000219334.5	-	5	2119	c.1516G>A	c.(1516-1518)Gtc>Atc	p.V506I	SMPD3_ENST00000568373.1_Missense_Mutation_p.V506I|SMPD3_ENST00000563226.1_Missense_Mutation_p.V506I|SMPD3_ENST00000566009.1_5'UTR	NM_018667.3	NP_061137.1	Q9NY59	NSMA2_HUMAN	sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)	506					cell cycle|multicellular organismal development|sphingomyelin catabolic process	Golgi membrane|integral to membrane|plasma membrane	metal ion binding|sphingomyelin phosphodiesterase activity			breast(1)|endometrium(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0184)|Epithelial(162;0.0785)	Phosphatidylserine(DB00144)	CCACAGACGACGTCAAATGCC	0.597000													19	11					0	0	1	0	0
PTPRF	5792	broad.mit.edu	37	1	44083216	44083216	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:44083216G>C	ENST00000359947.4	+	24	4512	c.4172G>C	c.(4171-4173)cGa>cCa	p.R1391P	PTPRF_ENST00000372414.3_Missense_Mutation_p.R1391P|PTPRF_ENST00000438120.1_Missense_Mutation_p.R1382P|PTPRF_ENST00000372413.3_Missense_Mutation_p.R1382P|PTPRF_ENST00000496447.1_3'UTR|PTPRF_ENST00000422171.2_Missense_Mutation_p.R750P	NM_002840.3	NP_002831.2	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	1391	Tyrosine-protein phosphatase 1.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(24)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)	72	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GACCACTCTCGAGTCATCCTT	0.552000													36	74					0	0	1	0	0
CD48	962	broad.mit.edu	37	1	160654693	160654693	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:160654693G>C	ENST00000368045.3	-	2	408	c.369C>G	c.(367-369)atC>atG	p.I123M	CD48_ENST00000368046.3_Missense_Mutation_p.I123M			P09326	CD48_HUMAN	CD48 molecule	123	Ig-like C2-type 1.				blood coagulation|defense response|leukocyte migration	integral to plasma membrane|membrane raft	protein binding			breast(2)|endometrium(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|stomach(1)	10	all_cancers(52;2.18e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			CTTGCAGCTTGATCTTCCATT	0.532000													39	965					0	0	1	0	0
MEIS3	56917	broad.mit.edu	37	19	47910681	47910681	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:47910681G>C	ENST00000331559.5	-	9	1391	c.950C>G	c.(949-951)cCg>cGg	p.P317R	MEIS3_ENST00000560253.1_5'UTR|MEIS3_ENST00000441740.2_Missense_Mutation_p.P271R|MEIS3_ENST00000558555.1_Missense_Mutation_p.P288R|MEIS3_ENST00000559524.1_Missense_Mutation_p.P334R|MEIS3_ENST00000561293.1_Missense_Mutation_p.P334R|MEIS3_ENST00000561096.1_Missense_Mutation_p.P376R	NM_020160.2	NP_064545.1	Q99687	MEIS3_HUMAN	Meis homeobox 3	288						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|large_intestine(5)|lung(11)|prostate(1)|skin(2)	20		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;0.000198)|OV - Ovarian serous cystadenocarcinoma(262;0.000439)|Epithelial(262;0.0113)|GBM - Glioblastoma multiforme(486;0.0223)		CGAGGGGTACGGGTGCTGCAG	0.687000													38	35					0	0	1	0	0
SLFN5	162394	broad.mit.edu	37	17	33586519	33586519	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr17:33586519G>C	ENST00000299977.4	+	2	958	c.810G>C	c.(808-810)caG>caC	p.Q270H	SLFN5_ENST00000592325.1_Missense_Mutation_p.Q270H|SLFN5_ENST00000542451.1_Missense_Mutation_p.Q270H	NM_144975.3	NP_659412.3	Q08AF3	SLFN5_HUMAN	schlafen family member 5	270					cell differentiation		ATP binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(8)|liver(2)|lung(6)|ovary(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(2)	34		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0191)		TCTGCACACAGAGGCCTGAGA	0.433000													37	136					0	0	1	0	0
NSMAF	8439	broad.mit.edu	37	8	59535800	59535800	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr8:59535800C>T	ENST00000038176.3	-	9	748	c.536G>A	c.(535-537)aGa>aAa	p.R179K	NSMAF_ENST00000427130.2_Missense_Mutation_p.R210K|NSMAF_ENST00000519858.1_5'UTR	NM_003580.3	NP_003571.2	Q92636	FAN_HUMAN	neutral sphingomyelinase (N-SMase) activation associated factor	179	GRAM.				ceramide metabolic process	cytoplasm|soluble fraction	protein binding|receptor signaling protein activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	38		all_lung(136;0.174)|Lung NSC(129;0.2)				AAATGATGTTCTAGCTAAACG	0.294000													5	24					0	0	1	0	0
PLEK	5341	broad.mit.edu	37	2	68609729	68609729	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:68609729G>A	ENST00000234313.7	+	4	615	c.436G>A	c.(436-438)Gag>Aag	p.E146K		NM_002664.2	NP_002655.2	P08567	PLEK_HUMAN	pleckstrin	146	DEP.				actin cytoskeleton reorganization|cortical actin cytoskeleton organization|hemopoietic progenitor cell differentiation|inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway|integrin-mediated signaling pathway|negative regulation of calcium-mediated signaling|negative regulation of inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|platelet aggregation|positive regulation of actin filament bundle assembly|positive regulation of actin filament depolymerization|positive regulation of inositol-polyphosphate 5-phosphatase activity|positive regulation of integrin activation|positive regulation of platelet activation|protein kinase C signaling cascade|protein secretion by platelet|regulation of cell diameter|ruffle organization|thrombin receptor signaling pathway|vesicle docking involved in exocytosis	cytosol|extracellular region|membrane fraction|ruffle membrane|soluble fraction	phosphatidylinositol-3,4-bisphosphate binding|protein homodimerization activity|protein kinase C binding			autonomic_ganglia(1)|endometrium(3)|large_intestine(6)|lung(12)|ovary(1)|skin(1)	24		Ovarian(717;0.0129)		STAD - Stomach adenocarcinoma(1183;0.00159)|READ - Rectum adenocarcinoma(193;0.0419)		ACTGAATCTAGAGAAGGACAA	0.393000													31	149					0	0	1	0	0
C16orf62	57020	broad.mit.edu	37	16	19693633	19693633	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr16:19693633G>C	ENST00000438132.3	+	28	2763	c.2715G>C	c.(2713-2715)gaG>gaC	p.E905D	C16orf62_ENST00000448695.1_Missense_Mutation_p.E666D|C16orf62_ENST00000417362.2_Missense_Mutation_p.E723D|C16orf62_ENST00000543152.1_Missense_Mutation_p.E565D|C16orf62_ENST00000542263.1_Missense_Mutation_p.E812D|C16orf62_ENST00000251143.5_Missense_Mutation_p.E816D	NM_020314.5	NP_064710.4	Q7Z3J2	CP062_HUMAN	chromosome 16 open reading frame 62	816						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(7)|liver(1)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	36						ACAGCGATGAGAAAATCCGCA	0.537000													40	154					0	0	1	0	0
CBY1	25776	broad.mit.edu	37	22	39064089	39064089	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr22:39064089G>A	ENST00000216029.3	+	2	164	c.30G>A	c.(28-30)ccG>ccA	p.P10P	RP3-508I15.9_ENST00000422408.2_RNA|RP3-508I15.9_ENST00000431924.2_RNA|RP3-508I15.10_ENST00000423346.1_RNA	NM_015373.3	NP_056188.1	Q9Y3M2	CBY1_HUMAN	chibby homolog 1 (Drosophila)	10					cardiac muscle cell differentiation|fat cell differentiation|negative regulation of transcription, DNA-dependent|protein localization	nuclear speck|trans-Golgi network	beta-catenin binding|identical protein binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|ovary(1)	4	Melanoma(58;0.04)					CGTTCAGTCCGAAGAAGACAC	0.537000													25	52					0	0	1	0	0
MINPP1	9562	broad.mit.edu	37	10	89265221	89265221	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr10:89265221C>T	ENST00000371996.4	+	1	590	c.549C>T	c.(547-549)tcC>tcT	p.S183S	MINPP1_ENST00000371994.4_Silent_p.S183S	NM_004897.4	NP_004888.2	Q9UNW1	MINP1_HUMAN	multiple inositol-polyphosphate phosphatase 1	183					bone mineralization|polyphosphate metabolic process	endoplasmic reticulum lumen	acid phosphatase activity|bisphosphoglycerate 3-phosphatase activity|multiple inositol-polyphosphate phosphatase activity|phosphohistidine phosphatase activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|urinary_tract(2)	5		Colorectal(252;0.122)		UCEC - Uterine corpus endometrioid carcinoma (6;0.00123)		TCACCAGTTCCAAGCACCGCT	0.682000											OREG0020348	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	17					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152579932	152579932	+	Silent	SNP	C	C	G			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:152579932C>G	ENST00000427231.2	-	9	883	c.681G>C	c.(679-681)ctG>ctC	p.L227L	NEB_ENST00000604864.1_Silent_p.L227L|NEB_ENST00000603639.1_Silent_p.L227L|NEB_ENST00000409198.1_Silent_p.L227L|NEB_ENST00000172853.10_Silent_p.L227L|NEB_ENST00000397345.3_Silent_p.L227L	NM_001164507.1|NM_001271208.1	NP_001157979|NP_001258137.1	P20929	NEBU_HUMAN	nebulin	227					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		CAACTCTCCTCAGTTCCGGGC	0.433000													8	8					0	0	1	0	0
ARG2	384	broad.mit.edu	37	14	68117488	68117488	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr14:68117488G>A	ENST00000261783.3	+	8	1096	c.916G>A	c.(916-918)Gaa>Aaa	p.E306K	VTI1B_ENST00000554659.1_3'UTR	NM_001172.3	NP_001163.1	P78540	ARGI2_HUMAN	arginase 2	306					arginine metabolic process|nitric oxide biosynthetic process|urea cycle	mitochondrial matrix	arginase activity|metal ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|ovary(1)|prostate(1)	11				all cancers(60;0.000582)|OV - Ovarian serous cystadenocarcinoma(108;0.00392)|BRCA - Breast invasive adenocarcinoma(234;0.00928)	L-Arginine(DB00125)|L-Ornithine(DB00129)	CACCTCAGAGGAAGAGGCGAA	0.478000													48	17					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34554657	34554657	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:34554657G>A	ENST00000373381.4	-	2	501	c.325C>T	c.(325-327)Cag>Tag	p.Q109*		NM_001281956.1|NM_052896.3	NP_001268885.1|NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	69	CUB 1.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GCAAAGGACTGGAACACAAGC	0.562000													18	31					0	0	1	0	0
KIF14	9928	broad.mit.edu	37	1	200574446	200574446	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:200574446G>A	ENST00000367350.4	-	8	2149	c.1711C>T	c.(1711-1713)Cat>Tat	p.H571Y		NM_014875.2	NP_055690.1	Q15058	KIF14_HUMAN	kinesin family member 14	571	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			NS(1)|breast(5)|central_nervous_system(2)|endometrium(8)|kidney(8)|large_intestine(15)|lung(13)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	61						AAAACTGAATGAGATCGGGAA	0.398000													6	51					0	0	1	0	0
EXOC2	55770	broad.mit.edu	37	6	617745	617745	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr6:617745G>A	ENST00000230449.4	-	6	762	c.627C>T	c.(625-627)ctC>ctT	p.L209L	EXOC2_ENST00000448181.3_Intron	NM_018303.5	NP_060773.3	Q96KP1	EXOC2_HUMAN	exocyst complex component 2	209					exocytosis|protein transport					breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|liver(1)|lung(16)|ovary(4)|pancreas(1)|prostate(2)	46	Ovarian(93;0.0733)	Breast(5;0.0014)|all_lung(73;0.0697)|all_hematologic(90;0.0897)		OV - Ovarian serous cystadenocarcinoma(45;0.0507)|BRCA - Breast invasive adenocarcinoma(62;0.14)		AGAATGTACTGAGACCGCCTT	0.537000													14	69					0	0	1	0	0
METTL24	728464	broad.mit.edu	37	6	110620123	110620123	+	Splice_Site	SNP	A	A	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr6:110620123A>T	ENST00000338882.4	-	4	786		c.e4+1			NM_001123364.1	NP_001116836.1	Q5JXM2	CF186_HUMAN	methyltransferase like 24							extracellular region											GAAAAACCTCACCTTGTGATG	0.383000													20	31					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26168328	26168328	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr22:26168328G>A	ENST00000335473.7	+	7	1970	c.1720G>A	c.(1720-1722)Gag>Aag	p.E574K	MYO18B_ENST00000536101.1_Missense_Mutation_p.E574K|MYO18B_ENST00000407587.2_Missense_Mutation_p.E574K	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	574	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						GGACCAGGTCGAGGACCTGGC	0.622000													30	53					0	0	1	0	0
NLRC5	84166	broad.mit.edu	37	16	57073702	57073702	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr16:57073702C>T	ENST00000436936.1	+	16	3036	c.2811C>T	c.(2809-2811)caC>caT	p.H937H	NLRC5_ENST00000262510.6_Silent_p.H937H|NLRC5_ENST00000308149.7_Silent_p.H937H|NLRC5_ENST00000539144.1_Silent_p.H937H			Q86WI3	NLRC5_HUMAN	NLR family, CARD domain containing 5	937					defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			NS(2)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(21)|ovary(8)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	75		all_neural(199;0.225)				GCCTGCAGCACAAAACTGTGA	0.527000													72	45					0	0	1	0	0
FZD7	8324	broad.mit.edu	37	2	202899764	202899764	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:202899764G>A	ENST00000286201.1	+	1	455	c.394G>A	c.(394-396)Gag>Aag	p.E132K		NM_003507.1	NP_003498.1	O75084	FZD7_HUMAN	frizzled family receptor 7	132	FZ.				axonogenesis|brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|mesenchymal to epithelial transition|negative regulation of cell-substrate adhesion|negative regulation of ectodermal cell fate specification|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of phosphorylation|positive regulation of transcription, DNA-dependent|regulation of catenin import into nucleus|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			breast(1)|endometrium(6)|large_intestine(6)|lung(11)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	31						CCAGGGCTGCGAGGCGCTCAT	0.657000											OREG0015146	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	58					0	0	1	0	0
UCK1	83549	broad.mit.edu	37	9	134405928	134405928	+	Silent	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr9:134405928C>T	ENST00000372215.4	-	2	306	c.213G>A	c.(211-213)ctG>ctA	p.L71L	UCK1_ENST00000372210.3_Silent_p.L62L|UCK1_ENST00000372211.3_Silent_p.L76L|UCK1_ENST00000459858.1_5'UTR|UCK1_ENST00000372208.3_Silent_p.L71L	NM_001261450.1|NM_001261451.1|NM_031432.2	NP_001248379.1|NP_001248380.1|NP_113620.1	Q9HA47	UCK1_HUMAN	uridine-cytidine kinase 1	71					pyrimidine base metabolic process|pyrimidine nucleoside salvage	cytosol	ATP binding|phosphotransferase activity, alcohol group as acceptor|uridine kinase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|skin(1)|upper_aerodigestive_tract(1)	6				OV - Ovarian serous cystadenocarcinoma(145;2.34e-05)|Epithelial(140;0.000219)		GCTCTGCCGTCAGGACCTTGT	0.562000													22	111					0	0	1	0	0
SSTR4	6754	broad.mit.edu	37	20	23016710	23016710	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr20:23016710C>A	ENST00000255008.3	+	1	654	c.590C>A	c.(589-591)gCc>gAc	p.A197D	RP4-753D10.3_ENST00000440921.1_RNA	NM_001052.2	NP_001043.2	P31391	SSR4_HUMAN	somatostatin receptor 4	197					G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|upper_aerodigestive_tract(1)	32	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)					CAGGCCGTGGCCTGCAACCTG	0.657000													80	47					2.17741e-50	2.37939e-50	1	1	0
KMT2C	58508	broad.mit.edu	37	7	151845834	151845834	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr7:151845834T>C	ENST00000355193.2	-	53	13567	c.13349A>G	c.(13348-13350)gAt>gGt	p.D4450G	KMT2C_ENST00000262189.6_Missense_Mutation_p.D4393G					lysine (K)-specific methyltransferase 2C																		GGGCACAGGATCAGGTTTAAG	0.418000													18	48					0	0	1	0	0
SEMA4A	64218	broad.mit.edu	37	1	156144962	156144962	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:156144962T>C	ENST00000368285.3	+	13	1787	c.1520T>C	c.(1519-1521)gTc>gCc	p.V507A	SEMA4A_ENST00000487358.1_3'UTR|SEMA4A_ENST00000368286.2_Missense_Mutation_p.V375A|SEMA4A_ENST00000355014.2_Missense_Mutation_p.V507A|SEMA4A_ENST00000368284.1_Missense_Mutation_p.V375A|SEMA4A_ENST00000368282.1_Missense_Mutation_p.V507A	NM_001193300.1|NM_022367.3	NP_001180229.1|NP_071762.2	Q9H3S1	SEM4A_HUMAN	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A	507	PSI.				axon guidance	integral to membrane|plasma membrane	receptor activity			breast(1)|ovary(2)|skin(2)	5	Hepatocellular(266;0.158)					GTGGACTGTGTCCTTGCCCGG	0.612000													158	194					0	0	1	0	0
MUT	4594	broad.mit.edu	37	6	49425571	49425571	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr6:49425571G>A	ENST00000274813.3	-	3	713	c.586C>T	c.(586-588)Ctt>Ttt	p.L196F		NM_000255.3	NP_000246.2	P22033	MUTA_HUMAN	methylmalonyl CoA mutase	196					fatty acid beta-oxidation	mitochondrial matrix	cobalamin binding|metal ion binding|methylmalonyl-CoA mutase activity			endometrium(2)|kidney(1)|large_intestine(4)|lung(17)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	30	Lung NSC(77;0.0376)				Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	AAATTTGCAAGAACTGGAATA	0.338000													12	29					0	0	1	0	0
UBIAD1	29914	broad.mit.edu	37	1	11333720	11333720	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:11333720G>A	ENST00000376810.5	+	1	458	c.132G>A	c.(130-132)caG>caA	p.Q44Q	UBIAD1_ENST00000376804.2_Silent_p.Q44Q	NM_013319.2	NP_037451.1	Q9Y5Z9	UBIA1_HUMAN	UbiA prenyltransferase domain containing 1	44					menaquinone biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrion|nucleus	prenyltransferase activity			endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|prostate(3)	12	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000818)|all_lung(284;0.00105)|Colorectal(325;0.0062)|Breast(348;0.012)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.52e-06)|COAD - Colon adenocarcinoma(227;0.000254)|BRCA - Breast invasive adenocarcinoma(304;0.000299)|Kidney(185;0.000754)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00727)|READ - Rectum adenocarcinoma(331;0.0487)		CCTGGAGGCAGAAGTGTGCCT	0.632000													10	48					0	0	1	0	0
AK2	204	broad.mit.edu	37	1	33480153	33480153	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:33480153G>A	ENST00000480134.1	-	4	421	c.373C>T	c.(373-375)Caa>Taa	p.Q125*	AK2_ENST00000548033.1_Silent_p.F114F|AK2_ENST00000354858.6_Silent_p.F156F|AK2_ENST00000467905.1_Silent_p.F156F|AK2_ENST00000373449.2_Silent_p.F156F|RP1-117O3.2_ENST00000427524.1_RNA			P54819	KAD2_HUMAN	adenylate kinase 2	0					nucleobase, nucleoside and nucleotide interconversion	mitochondrial intermembrane space	adenylate kinase activity|ATP binding			kidney(1)|large_intestine(2)|lung(4)|skin(1)	8		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)				TTGGAGGGTTGAACTCCTCGT	0.438000													53	150					0	0	1	0	0
BRCA2	675	broad.mit.edu	37	13	32913668	32913668	+	Missense_Mutation	SNP	G	G	A	rs80359491		TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr13:32913668G>A	ENST00000544455.1	+	11	5403	c.5176G>A	c.(5176-5178)Gaa>Aaa	p.E1726K	BRCA2_ENST00000380152.3_Missense_Mutation_p.E1726K	NM_000059.3	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	1726					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			NS(3)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(32)|liver(1)|lung(41)|oesophagus(5)|ovary(22)|pancreas(4)|prostate(3)|salivary_gland(1)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	183		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		TACTATAGCTGAAAATGACAA	0.303000			"""D, Mis, N, F, S"""		"""breast, ovarian, pancreatic"""	"""breast, ovarian, pancreatic, leukemia  (FANCB, FANCD1)"""		Homologous recombination	Pancreatic Cancer, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Prostate Cancer;Hereditary Breast-Ovarian Cancer, BRCA2 type;Fanconi Anemia type D1, bi-allelic BRCA2 mutations;Fanconi Anemia	TCGA Ovarian(8;0.087)			8	22					0	0	1	0	0
SPDYC	387778	broad.mit.edu	37	11	64939750	64939750	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr11:64939750C>T	ENST00000377185.2	+	4	374	c.292C>T	c.(292-294)Cgc>Tgc	p.R98C		NM_001008778.1	NP_001008778.1	Q5MJ68	SPDYC_HUMAN	speedy/RINGO cell cycle regulator family member C	98	Speedy/Ringo box; Required for CDK- binding (By similarity).				cell cycle	nucleus	protein kinase binding			breast(1)|endometrium(3)|large_intestine(2)|lung(9)|prostate(1)	16						CTACTTCCAGCGCGCCCACCT	0.592000													33	59					0	0	1	0	0
DHX16	8449	broad.mit.edu	37	6	30638837	30638837	+	Missense_Mutation	SNP	G	G	A	rs140342281		TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr6:30638837G>A	ENST00000376442.3	-	2	617	c.422C>T	c.(421-423)tCt>tTt	p.S141F		NM_001164239.1|NM_003587.4	NP_001157711.1|NP_003578.2	O60231	DHX16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 16	141					mRNA processing|RNA splicing	nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|RNA helicase activity			kidney(2)|ovary(2)	4						CCCTTTCTCAGAAGCCTCTTC	0.507000													144	103					0	0	1	0	0
CYHR1	50626	broad.mit.edu	37	8	145689768	145689768	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr8:145689768G>A	ENST00000403000.2	-	2	908	c.321C>T	c.(319-321)ctC>ctT	p.L107L	CTD-2517M22.16_ENST00000525461.1_RNA|CYHR1_ENST00000424149.2_Silent_p.L107L|CYHR1_ENST00000438911.2_Intron|CYHR1_ENST00000306145.5_Silent_p.L107L	NM_032687.3	NP_116076.1	Q6ZMK1	CYHR1_HUMAN	cysteine/histidine-rich 1	103						perinuclear region of cytoplasm	zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|lung(3)|ovary(2)	7	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			CCTCAGGGCCGAGGTGGCCGC	0.617000													23	40					0	0	1	0	0
MTFR1L	56181	broad.mit.edu	37	1	26158516	26158516	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:26158516G>A	ENST00000374301.3	+	7	1186	c.878G>A	c.(877-879)tGa>tAa	p.*293*	MTFR1L_ENST00000524618.1_Silent_p.*196*|MTFR1L_ENST00000374307.5_Silent_p.*281*|AUNIP_ENST00000538789.1_3'UTR|MTFR1L_ENST00000374300.3_Silent_p.*293*|MTFR1L_ENST00000374303.2_Silent_p.*293*|MTFR1L_ENST00000474295.1_3'UTR|MTFR1L_ENST00000466284.1_3'UTR|MTFR1L_ENST00000469815.1_3'UTR|RP1-317E23.7_ENST00000606617.1_RNA	NM_019557.5	NP_062457.3			mitochondrial fission regulator 1-like																		AAAGGAAATTGACAACCCTCA	0.453000													19	31					0	0	1	0	0
SNX17	9784	broad.mit.edu	37	2	27598981	27598981	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr2:27598981G>A	ENST00000233575.2	+	12	1335	c.1113G>A	c.(1111-1113)atG>atA	p.M371I	SNX17_ENST00000542478.1_Missense_Mutation_p.M157I|SNX17_ENST00000543024.1_Missense_Mutation_p.M157I|SNX17_ENST00000537606.1_Missense_Mutation_p.M346I	NM_001267059.1|NM_001267061.1|NM_014748.3	NP_001253988.1|NP_001253990.1|NP_055563.1	Q15036	SNX17_HUMAN	sorting nexin 17	371					cell communication|endosome transport|intracellular protein transport|regulation of endocytosis|signal transduction	cytoplasmic vesicle membrane|cytosol|early endosome|Golgi apparatus	low-density lipoprotein particle receptor binding|phosphatidylinositol binding|protein C-terminus binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(4)|ovary(1)	14	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGGCTATCATGATGAGCATCT	0.507000													31	112					0	0	1	0	0
KCTD17	79734	broad.mit.edu	37	22	37458602	37458602	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr22:37458602G>A	ENST00000403888.3	+	9	935	c.934G>A	c.(934-936)Gat>Aat	p.D312N	KCTD17_ENST00000402077.3_Missense_Mutation_p.D288N	NM_001282684.1	NP_001269613.1	Q8N5Z5	KCD17_HUMAN	potassium channel tetramerization domain containing 17	312						voltage-gated potassium channel complex	identical protein binding|voltage-gated potassium channel activity			NS(1)|breast(1)|endometrium(1)|lung(1)|prostate(1)	5						TGAGGCCCCAGATCACCTCCA	0.602000													3	13					0	0	1	0	0
GPAM	57678	broad.mit.edu	37	10	113928198	113928198	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr10:113928198C>A	ENST00000348367.4	-	11	1176	c.979G>T	c.(979-981)Gct>Tct	p.A327S	GPAM_ENST00000423155.1_Missense_Mutation_p.A327S|GPAM_ENST00000369425.1_Missense_Mutation_p.A327S			Q9HCL2	GPAT1_HUMAN	glycerol-3-phosphate acyltransferase, mitochondrial	327					phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity			breast(2)|central_nervous_system(2)|endometrium(8)|kidney(2)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31				Epithelial(162;0.0306)|all cancers(201;0.123)		CCTGCCCGAGCACAAGAGGTT	0.428000													19	50					6.49762e-13	6.92793e-13	1	1	0
RB1	5925	broad.mit.edu	37	13	48947629	48947629	+	Splice_Site	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr13:48947629G>A	ENST00000267163.4	+	12	1353		c.e12+1			NM_000321.2	NP_000312.2	P06400	RB_HUMAN	retinoblastoma 1						androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(23)|p.0?(15)		NS(3)|adrenal_gland(1)|bone(22)|breast(30)|central_nervous_system(48)|cervix(3)|endometrium(14)|eye(95)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(20)|kidney(3)|large_intestine(10)|liver(3)|lung(153)|oesophagus(1)|ovary(13)|pancreas(5)|pituitary(1)|prostate(14)|salivary_gland(2)|skin(9)|soft_tissue(9)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(31)	496		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CTATTTTAACGTAAGCCATAT	0.279000		6	"""D, Mis, N, F, S"""		"""retinoblastoma, sarcoma, breast, small cell lung"""	"""retinoblastoma, sarcoma, breast, small cell lung"""			Hereditary Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			14	42					0	0	1	0	0
SRPRB	58477	broad.mit.edu	37	3	133525481	133525481	+	Silent	SNP	G	G	A			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:133525481G>A	ENST00000466490.2	+	3	468	c.183G>A	c.(181-183)agG>agA	p.R61R		NM_021203.3	NP_067026.3	Q9Y5M8	SRPRB_HUMAN	signal recognition particle receptor, B subunit	61						endoplasmic reticulum membrane|integral to membrane	GTP binding|protein binding|receptor activity			breast(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)|urinary_tract(2)	12						GGAGCAGAAGGAGCAGTCAGA	0.448000													5	68					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34254244	34254253	+	Frame_Shift_Del	DEL	AGTCTGGAAG	AGTCTGGAAG	-			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:34254244_34254253delAGTCTGGAAG	ENST00000373381.4	-	12	1787_1796	c.1611_1620delCTTCCAGACT	c.(1609-1620)ctcttccagactfs	p.LFQT537fs	CSMD2_ENST00000338325.1_Frame_Shift_Del_p.LFQT145fs	NM_001281956.1|NM_052896.3	NP_001268885.1|NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	497	Sushi 3.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CACTGCCATCAGTCTGGAAGAGGAGCCACA	0.519													12	70	---	---	---	---					
NFASC	23114	broad.mit.edu	37	1	204948193	204948194	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:204948193_204948194delCA	ENST00000367172.4	+	18	2302_2303	c.1974_1975delCA	c.(1972-1977)atcacafs	p.T659fs	NFASC_ENST00000367171.4_Frame_Shift_Del_p.T644fs|NFASC_ENST00000338586.6_Frame_Shift_Del_p.T659fs|NFASC_ENST00000401399.1_Frame_Shift_Del_p.T659fs|NFASC_ENST00000404907.1_Frame_Shift_Del_p.T655fs|NFASC_ENST00000339876.6_Frame_Shift_Del_p.T659fs|NFASC_ENST00000513543.1_Frame_Shift_Del_p.T655fs|NFASC_ENST00000404076.1_Frame_Shift_Del_p.T638fs|NFASC_ENST00000367170.4_Frame_Shift_Del_p.T659fs|NFASC_ENST00000539706.1_Frame_Shift_Del_p.T655fs|NFASC_ENST00000367169.4_Frame_Shift_Del_p.T659fs|NFASC_ENST00000338515.6_Frame_Shift_Del_p.T659fs|NFASC_ENST00000360049.4_Frame_Shift_Del_p.T655fs			O94856	NFASC_HUMAN	neurofascin	659	Fibronectin type-III 1.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			ACAGCCCCATCACAGGTAGCTC	0.644													2	4	---	---	---	---					
USH2A	7399	broad.mit.edu	37	1	215848634	215848634	+	Frame_Shift_Del	DEL	C	C	-			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:215848634delC	ENST00000366943.2	-	63	13005	c.12619delG	c.(12619-12621)gccfs	p.A4207fs	USH2A_ENST00000307340.3_Frame_Shift_Del_p.A4207fs			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	4207	Fibronectin type-III 27.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TTCTCGTCGGCCTGGATTGTC	0.398										HNSCC(13;0.011)			20	97	---	---	---	---					
OBSCN	84033	broad.mit.edu	37	1	228465508	228465512	+	Frame_Shift_Del	DEL	ATCCA	ATCCA	-			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr1:228465508_228465512delATCCA	ENST00000570156.2	+	30	8169_8173	c.8095_8099delATCCA	c.(8095-8100)atccaafs	p.IQ2699fs	OBSCN_ENST00000284548.11_Frame_Shift_Del_p.IQ2270fs|OBSCN_ENST00000366709.4_5'UTR|OBSCN_ENST00000359599.6_Frame_Shift_Del_p.IQ1117fs|OBSCN_ENST00000422127.1_Frame_Shift_Del_p.IQ2270fs|OBSCN_ENST00000366707.4_5'UTR	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	1696	Ig-like 26.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				TGCAGGAGAGATCCAATTTGTAGCC	0.610													25	57	---	---	---	---					
CACNA1D	776	broad.mit.edu	37	3	53529193	53529195	+	Translation_Start_Site	DEL	GAT	GAT	-			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:53529193_53529195delGAT	ENST00000288139.4	+	0	118_120				CACNA1D_ENST00000350061.5_Start_Codon_Del|CACNA1D_ENST00000422281.2_Start_Codon_Del	NM_000720.2	NP_000711.1	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type, alpha 1D subunit						axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			breast(3)|central_nervous_system(9)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(13)|liver(1)|lung(29)|ovary(6)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	90				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	aatgttcgtGgatgatgatgatg	0.581													7	114	---	---	---	---					
DENND6A	201627	broad.mit.edu	37	3	57646498	57646498	+	Frame_Shift_Del	DEL	C	C	-			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr3:57646498delC	ENST00000311128.5	-	7	758	c.688delG	c.(688-690)gtgfs	p.V231fs		NM_152678.2	NP_689891.1			DENN/MADD domain containing 6A																		TTCATTACCACCCCCATGATT	0.368													15	52	---	---	---	---					
CEP72	55722	broad.mit.edu	37	5	640649	640651	+	In_Frame_Del	DEL	AGC	AGC	-			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr5:640649_640651delAGC	ENST00000264935.5	+	9	1559_1561	c.1469_1471delAGC	c.(1468-1473)gagcag>gag	p.Q494del	CEP72_ENST00000444221.1_3'UTR	NM_018140.3	NP_060610.2	Q9P209	CEP72_HUMAN	centrosomal protein 72kDa	494					G2/M transition of mitotic cell cycle|gamma-tubulin complex localization|spindle organization	centrosome|cytosol				autonomic_ganglia(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(1)|liver(1)|lung(5)|ovary(2)|prostate(3)|skin(1)|stomach(1)|urinary_tract(2)	20			Epithelial(17;0.000339)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|Lung(60;0.0863)			CGCCTTGCTGAGCAGCAGCAGCA	0.621													7	901	---	---	---	---					
IRX4	50805	broad.mit.edu	37	5	1879669	1879671	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr5:1879669_1879671delCCT	ENST00000505790.1	-	5	1139_1141	c.683_685delAGG	c.(682-687)gagggg>ggg	p.E228del	IRX4_ENST00000231357.2_In_Frame_Del_p.E228del|IRX4_ENST00000505938.1_5'UTR|IRX4_ENST00000513692.1_In_Frame_Del_p.E228del	NM_001278634.1	NP_001265563.1	P78413	IRX4_HUMAN	iroquois homeobox 4	228	Poly-Glu.				heart development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|lung(7)|ovary(1)|prostate(1)	10				GBM - Glioblastoma multiforme(108;0.242)		tcctcgcccccctcctcctcctc	0.685													10	400	---	---	---	---					
LINC00518	221718	broad.mit.edu	37	6	10430699	10430701	+	RNA	DEL	TTT	TTT	-	rs79230388		TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr6:10430699_10430701delTTT	ENST00000496285.1	-	0	489					NR_027793.1																						CTCTGACTAGttttttttttttt	0.448													3	4	---	---	---	---					
ERLIN2	11160	broad.mit.edu	37	8	37595525	37595528	+	Frame_Shift_Del	DEL	GGAC	GGAC	-			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr8:37595525_37595528delGGAC	ENST00000276461.5	+	2	152_155	c.85_88delGGAC	c.(85-90)ggacatfs	p.GH29fs	ERLIN2_ENST00000523107.1_Frame_Shift_Del_p.GH29fs|ERLIN2_ENST00000335171.6_Frame_Shift_Del_p.GH29fs|ERLIN2_ENST00000519638.1_Frame_Shift_Del_p.GH29fs|ERLIN2_ENST00000518586.1_Frame_Shift_Del_p.GH29fs|ERLIN2_ENST00000397228.2_Frame_Shift_Del_p.GH29fs|ERLIN2_ENST00000523887.1_Frame_Shift_Del_p.GH29fs	NM_007175.6	NP_009106.1	O94905	ERLN2_HUMAN	ER lipid raft associated 2	29					ER-associated protein catabolic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	protein binding			NS(1)|large_intestine(1)|lung(5)	7		Lung NSC(58;0.174)	BRCA - Breast invasive adenocarcinoma(5;6.14e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)			GATAGAAGAGGGACATATTGGGGT	0.480													20	34	---	---	---	---					
VIM	7431	broad.mit.edu	37	10	17277291	17277296	+	In_Frame_Del	DEL	CGTCAC	CGTCAC	-			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr10:17277291_17277296delCGTCAC	ENST00000544301.1	+	7	1545_1550	c.1132_1137delCGTCAC	c.(1132-1137)cgtcacdel	p.RH378del	VIM_ENST00000224237.5_In_Frame_Del_p.RH378del	NM_003380.3	NP_003371.2	P08670	VIME_HUMAN	vimentin	378	Coil 2.|Rod.				cellular component disassembly involved in apoptosis|cellular component movement|interspecies interaction between organisms|muscle filament sliding	cytosol|intermediate filament	protein C-terminus binding|structural constituent of cytoskeleton			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(2)|lung(18)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						GGAAATGGCTCGTCACCTTCGTGAAT	0.495													14	97	---	---	---	---					
MRVI1	10335	broad.mit.edu	37	11	10673582	10673582	+	Frame_Shift_Del	DEL	G	G	-			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr11:10673582delG	ENST00000423302.2	-	2	364	c.215delC	c.(214-216)cctfs	p.P72fs	MRVI1_ENST00000558540.1_5'UTR|MRVI1_ENST00000534266.2_5'UTR|MRVI1_ENST00000532037.1_5'UTR|MRVI1_ENST00000424001.1_5'UTR|MRVI1_ENST00000531107.1_Frame_Shift_Del_p.P63fs|MRVI1_ENST00000545852.1_5'UTR|MRVI1_ENST00000552103.1_5'UTR|MRVI1_ENST00000541483.1_Frame_Shift_Del_p.P72fs|MRVI1_ENST00000547195.1_Intron|MRVI1_ENST00000527509.2_Intron|MRVI1_ENST00000436272.1_Frame_Shift_Del_p.P63fs|MRVI1_ENST00000421747.1_Frame_Shift_Del_p.P63fs	NM_001206880.1|NM_130385.3	NP_001193809.1|NP_569056.4	Q9Y6F6	MRVI1_HUMAN	murine retrovirus integration site 1 homolog	63					platelet activation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum				central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|prostate(2)	22				all cancers(16;2.68e-07)|Epithelial(150;3.04e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0723)		TTGGCCGGCAGGGCTCTGGGC	0.692													2	4	---	---	---	---					
NAV2	89797	broad.mit.edu	37	11	20117311	20117312	+	Splice_Site	DEL	AA	AA	-			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr11:20117311_20117312delAA	ENST00000396085.1	+	31	6380_6381	c.6019_6020delAA	c.(6019-6021)aaa>a	p.K2007fs	NAV2_ENST00000349880.4_Splice_Site_p.K2004fs|NAV2_ENST00000533917.1_Splice_Site_p.K1068fs|NAV2_ENST00000360655.4_Splice_Site_p.K1940fs|NAV2_ENST00000527559.2_Splice_Site_p.K1992fs|NAV2_ENST00000396087.3_Splice_Site_p.K2063fs|NAV2_ENST00000311043.8_Splice_Site_p.K1068fs|NAV2_ENST00000540292.1_Splice_Site_p.K1994fs	NM_182964.5	NP_892009.3	Q8IVL1	NAV2_HUMAN	neuron navigator 2	2063						nucleus	ATP binding|helicase activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(26)|lung(38)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	116						ACGGCTGTTCAAAGTAAGTGTT	0.500													43	102	---	---	---	---					
NAV3	89795	broad.mit.edu	37	12	78444867	78444873	+	Frame_Shift_Del	DEL	GATATAT	GATATAT	-			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr12:78444867_78444873delGATATAT	ENST00000397909.2	+	11	2629_2635	c.2456_2462delGATATAT	c.(2455-2463)ggatatatgfs	p.GYM819fs	NAV3_ENST00000536525.2_Frame_Shift_Del_p.GYM819fs|NAV3_ENST00000266692.7_Frame_Shift_Del_p.GYM819fs|NAV3_ENST00000228327.6_Frame_Shift_Del_p.GYM819fs			Q8IVL0	NAV3_HUMAN	neuron navigator 3	819						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						GATGTGGGTGGATATATGAGTGATGGT	0.493										HNSCC(70;0.22)			20	35	---	---	---	---					
GOLGA8DP	100132979	broad.mit.edu	37	15	22709885	22709885	+	RNA	DEL	G	G	-			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr15:22709885delG	ENST00000314246.8	-	0	1069																											TATCTAATGTGGGGGGGGCTG	0.537													3	4	---	---	---	---					
CHD2	1106	broad.mit.edu	37	15	93498666	93498676	+	Frame_Shift_Del	DEL	AATGGATTCAT	AATGGATTCAT	-			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr15:93498666_93498676delAATGGATTCAT	ENST00000394196.4	+	15	2801_2811	c.1733_1743delAATGGATTCAT	c.(1732-1743)gaatggattcatfs	p.EWIH578fs	CHD2_ENST00000557381.1_Frame_Shift_Del_p.EWIH578fs	NM_001271.3	NP_001262.3	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	578	Helicase ATP-binding.				regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding	p.W579R(1)		breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(10)|lung(17)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	47	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			CGGGAATATGAATGGATTCATTCCCAAACCA	0.280													7	11	---	---	---	---					
ZNF546	339327	broad.mit.edu	37	19	40520001	40520002	+	Frame_Shift_Ins	INS	-	-	T			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr19:40520001_40520002insT	ENST00000347077.4	+	7	1040_1041	c.824_825insT	c.(823-828)tgtaaafs	p.K276fs	ZNF546_ENST00000596894.1_Intron|ZNF546_ENST00000600094.1_Frame_Shift_Ins_p.K250fs	NM_178544.3	NP_848639.2	Q86UE3	ZN546_HUMAN	zinc finger protein 546	276					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(15)|lung(6)|ovary(3)|skin(2)|upper_aerodigestive_tract(3)	34	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					CCCTATGAATGTAAAGAATGTG	0.436													18	43	---	---	---	---					
VAPB	9217	broad.mit.edu	37	20	57019274	57019274	+	Frame_Shift_Del	DEL	G	G	-			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr20:57019274delG	ENST00000475243.1	+	6	1053	c.715delG	c.(715-717)gggfs	p.G239fs	VAPB_ENST00000265619.2_3'UTR|VAPB_ENST00000395802.3_3'UTR	NM_004738.4	NP_004729.1	O95292	VAPB_HUMAN	VAMP (vesicle-associated membrane protein)-associated protein B and C	239					cell death|endoplasmic reticulum unfolded protein response|positive regulation of viral genome replication|sphingolipid metabolic process|virus-host interaction	endoplasmic reticulum membrane|Golgi apparatus|integral to membrane	beta-tubulin binding|enzyme binding|protein heterodimerization activity|protein homodimerization activity|structural molecule activity			kidney(2)|lung(3)|prostate(1)	6	Lung NSC(12;0.000615)|all_lung(29;0.00186)		BRCA - Breast invasive adenocarcinoma(13;6.2e-12)|Epithelial(14;3.7e-08)|all cancers(14;3.88e-07)			TGTAATTATTGGGAAGATTGC	0.438													29	87	---	---	---	---					
CABIN1	23523	broad.mit.edu	37	22	24466884	24466884	+	Frame_Shift_Del	DEL	A	A	-			TCGA-ZF-AA4V-01A-11D-A38G-08	TCGA-ZF-AA4V-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33dad043-e9f3-4e53-9c31-498735b4d9ef	07835d12-d051-4a4a-8ad4-08277ccc141e	g.chr22:24466884delA	ENST00000398319.2	+	17	2751	c.2366delA	c.(2365-2367)caafs	p.Q789fs	CABIN1_ENST00000263119.5_Frame_Shift_Del_p.Q789fs|CABIN1_ENST00000405822.2_Frame_Shift_Del_p.Q739fs	NM_001199281.1	NP_001186210.1	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	789					cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			breast(2)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(13)|liver(1)|lung(18)|ovary(5)|pancreas(3)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	65						ACAGTGACCCAACTGCTGATG	0.587													15	30	---	---	---	---