Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
FTSJ3	117246	broad.mit.edu	37	17	61897259	61897259	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr17:61897259C>G	ENST00000427159.2	-	21	3092	c.2447G>C	c.(2446-2448)gGa>gCa	p.G816A		NM_017647.3	NP_060117.3	Q8IY81	RRMJ3_HUMAN	FtsJ homolog 3 (E. coli)	816					RNA methylation|rRNA processing	nucleolus	methyltransferase activity|nucleic acid binding			breast(2)|central_nervous_system(1)|endometrium(6)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	27						ACCTCTGACTCCAGCTGGCCG	0.498000													88	79					0	0	1	0	0
TRPM2	7226	broad.mit.edu	37	21	45799047	45799047	+	Silent	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr21:45799047C>T	ENST00000397928.1	+	8	1627	c.1182C>T	c.(1180-1182)ttC>ttT	p.F394F	TRPM2_ENST00000300482.5_Silent_p.F394F|TRPM2_ENST00000397932.2_Silent_p.F394F|TRPM2_ENST00000498430.1_3'UTR|TRPM2_ENST00000300481.9_Silent_p.F394F	NM_003307.3	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	394						integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						TTGAGACCTTCACGGAAAGCA	0.557000													26	44					0	0	1	0	0
OBP2A	29991	broad.mit.edu	37	9	138438707	138438707	+	Silent	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr9:138438707G>A	ENST00000539850.1	+	2	182	c.156G>A	c.(154-156)gtG>gtA	p.V52V	OBP2A_ENST00000371776.1_Silent_p.V52V|OBP2A_ENST00000340780.3_Silent_p.V52V|OBP2A_ENST00000342114.4_Intron			Q9NY56	OBP2A_HUMAN	odorant binding protein 2A	52					response to stimulus|sensory perception of smell	extracellular region	odorant binding|transporter activity			endometrium(1)|large_intestine(4)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	11				OV - Ovarian serous cystadenocarcinoma(145;3.39e-07)|Epithelial(140;1.11e-06)|all cancers(34;2.04e-05)		TGTCCCCAGTGAAGGTGACAG	0.627000													22	20					0	0	1	0	0
ZNF383	163087	broad.mit.edu	37	19	37733679	37733679	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr19:37733679C>T	ENST00000589413.1	+	8	1124	c.541C>T	c.(541-543)Cag>Tag	p.Q181*	ZNF383_ENST00000590503.1_Nonsense_Mutation_p.Q181*|ZNF383_ENST00000352998.3_Nonsense_Mutation_p.Q181*			Q8NA42	ZN383_HUMAN	zinc finger protein 383	181					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(8)|ovary(1)|skin(1)	15			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GGCCTTTAGTCAGAACTCACA	0.333000													23	21					0	0	1	0	0
ST8SIA5	29906	broad.mit.edu	37	18	44260143	44260143	+	Silent	SNP	G	G	C			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr18:44260143G>C	ENST00000315087.7	-	7	1653	c.993C>G	c.(991-993)ctC>ctG	p.L331L	ST8SIA5_ENST00000590497.1_5'UTR|ST8SIA5_ENST00000536490.1_Silent_p.L300L|ST8SIA5_ENST00000538168.1_Silent_p.L367L	NM_013305.4	NP_037437.2	O15466	SIA8E_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5	331					glycosphingolipid biosynthetic process|protein glycosylation	integral to Golgi membrane				kidney(1)|large_intestine(10)|lung(7)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(2)	22						GAGTGATGTAGAGGCCCGAGG	0.602000													32	60					0	0	1	0	0
CDKN2A	1029	broad.mit.edu	37	9	21971114	21971114	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr9:21971114C>T	ENST00000579755.1	-	2	579	c.287G>A	c.(286-288)cGt>cAt	p.R96H	CDKN2A_ENST00000579122.1_Missense_Mutation_p.V82M|CDKN2A_ENST00000498124.1_Missense_Mutation_p.V82M|CDKN2A_ENST00000304494.5_Missense_Mutation_p.V82M|CDKN2A_ENST00000494262.1_Missense_Mutation_p.V31M|CDKN2A_ENST00000361570.3_Missense_Mutation_p.R137H|RP11-145E5.5_ENST00000404796.2_Intron|CDKN2A_ENST00000479692.2_Missense_Mutation_p.V31M|CDKN2A_ENST00000578845.2_Missense_Mutation_p.V31M|CDKN2A_ENST00000497750.1_Missense_Mutation_p.V31M|CDKN2A_ENST00000530628.2_Missense_Mutation_p.R96H|CDKN2A_ENST00000498628.2_Missense_Mutation_p.V31M|CDKN2A_ENST00000446177.1_Missense_Mutation_p.V82M			P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A	0					cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein kinase binding	p.0?(1315)|p.?(44)|p.V82M(2)|p.V82fs*62(1)|p.0(1)|p.T79fs*37(1)|p.E61_L94del(1)|p.R137fs*48(1)|p.A68fs*3(1)|p.P81_A85del(1)|p.R80fs*34(1)|p.V82_E88del(1)|p.V82L(1)|p.P81fs*38(1)|p.V82fs*44(1)		NS(28)|adrenal_gland(6)|autonomic_ganglia(11)|biliary_tract(74)|bone(84)|breast(46)|central_nervous_system(522)|cervix(23)|endometrium(14)|eye(4)|genital_tract(15)|haematopoietic_and_lymphoid_tissue(698)|kidney(39)|large_intestine(11)|liver(92)|lung(365)|meninges(18)|oesophagus(239)|ovary(98)|pancreas(263)|pleura(94)|prostate(13)|salivary_gland(10)|skin(541)|small_intestine(1)|soft_tissue(93)|stomach(48)|thymus(4)|thyroid(24)|upper_aerodigestive_tract(436)|urinary_tract(283)|vulva(2)	4199		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		GCGTCGTGCACGGGTCGGGTG	0.741000		17								HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			9	9					0	0	1	0	0
POTEE	445582	broad.mit.edu	37	2	132021595	132021595	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr2:132021595G>A	ENST00000356920.5	+	15	2661	c.2567G>A	c.(2566-2568)gGt>gAt	p.G856D	PLEKHB2_ENST00000303908.3_Intron|PLEKHB2_ENST00000404460.1_Intron|POTEE_ENST00000358087.5_3'UTR	NM_001083538.1	NP_001077007.1	Q6S8J3	POTEE_HUMAN	POTE ankyrin domain family, member E	856	Actin-like.						ATP binding										ATGGACTCTGGTGACGGGGTC	0.617000													29	61					0	0	1	0	0
CC2D1A	54862	broad.mit.edu	37	19	14024046	14024046	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr19:14024046G>C	ENST00000318003.7	+	5	685	c.444G>C	c.(442-444)caG>caC	p.Q148H	CC2D1A_ENST00000589606.1_Missense_Mutation_p.Q148H	NM_017721.4	NP_060191.3	Q6P1N0	C2D1A_HUMAN	coiled-coil and C2 domain containing 1A	148					positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus|plasma membrane	DNA binding|signal transducer activity			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(12)|prostate(2)|skin(2)	27			OV - Ovarian serous cystadenocarcinoma(19;3.49e-23)			CGCTCTATCAGACAGCAATTG	0.632000													10	8					0	0	1	0	0
FGG	2266	broad.mit.edu	37	4	155529686	155529686	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr4:155529686C>G	ENST00000404648.3	-	7	1022	c.783G>C	c.(781-783)ttG>ttC	p.L261F	FGG_ENST00000405164.1_Missense_Mutation_p.L269F|FGG_ENST00000336098.3_Missense_Mutation_p.L261F|FGG_ENST00000407946.1_Missense_Mutation_p.L269F	NM_000509.4	NP_000500.2	P02679	FIBG_HUMAN	fibrinogen gamma chain	261	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding	p.L261L(1)		breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(9)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	27	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	GTGTGCTTATCAAATGAATCT	0.383000													31	9					0	0	1	0	0
NBPF9	400818	broad.mit.edu	37	1	144828657	144828657	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr1:144828657G>A	ENST00000338347.4	+	14	1703	c.1703G>A	c.(1702-1704)aGa>aAa	p.R568K	NBPF9_ENST00000468645.1_3'UTR|NBPF9_ENST00000440491.2_3'UTR|NBPF9_ENST00000281815.8_Missense_Mutation_p.R166K					neuroblastoma breakpoint family, member 9											NS(2)|prostate(1)	3						CAGCACTACAGAAGTGTGTTT	0.448000													7	196					0	0	1	0	0
ENTPD8	377841	broad.mit.edu	37	9	140329478	140329478	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr9:140329478T>A	ENST00000371506.2	-	10	1559	c.1376A>T	c.(1375-1377)cAg>cTg	p.Q459L	ENTPD8_ENST00000472938.1_Missense_Mutation_p.Q459L|ENTPD8_ENST00000344119.2_Missense_Mutation_p.Q422L	NM_001033113.1	NP_001028285.1	Q5MY95	ENTP8_HUMAN	ectonucleoside triphosphate diphosphohydrolase 8	459						integral to membrane|plasma membrane	ATP binding			biliary_tract(1)|lung(4)|prostate(1)|skin(1)	7	all_cancers(76;0.0926)			OV - Ovarian serous cystadenocarcinoma(145;0.000224)|Epithelial(140;0.000898)		TGCCCGCCACTGAGCCGGCGC	0.672000													9	14					0	0	1	0	0
POC1A	25886	broad.mit.edu	37	3	52109918	52109918	+	Silent	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr3:52109918C>T	ENST00000394970.2	-	10	1382	c.1065G>A	c.(1063-1065)caG>caA	p.Q355Q	POC1A_ENST00000296484.2_Silent_p.Q403Q|POC1A_ENST00000474012.1_Silent_p.Q365Q	NM_001161580.1	NP_001155052.1	Q8NBT0	POC1A_HUMAN	POC1 centriolar protein A	403						centriole|microtubule basal body				endometrium(1)|large_intestine(4)|liver(1)|lung(4)|prostate(3)|skin(1)	14						GTGTTGCTCTCTGCATGATTA	0.512000													91	54					0	0	1	0	0
GPR160	26996	broad.mit.edu	37	3	169802467	169802467	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr3:169802467C>A	ENST00000355897.5	+	4	1315	c.707C>A	c.(706-708)tCt>tAt	p.S236Y		NM_014373.2	NP_055188.1	Q9UJ42	GP160_HUMAN	G protein-coupled receptor 160	236						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|cervix(1)|kidney(1)|large_intestine(3)|lung(2)	8	all_cancers(22;3.26e-22)|all_epithelial(15;5.71e-27)|all_lung(20;8.41e-17)|Lung NSC(18;3.49e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0655)			ACTGTGAGATCTAAAAAAATA	0.323000													46	31					1.8453e-21	1.99673e-21	1	1	0
SYNE1	23345	broad.mit.edu	37	6	152749478	152749478	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr6:152749478G>A	ENST00000367255.5	-	37	5439	c.4838C>T	c.(4837-4839)tCa>tTa	p.S1613L	SYNE1_ENST00000423061.1_Missense_Mutation_p.S1620L|SYNE1_ENST00000367253.4_Missense_Mutation_p.S1613L|SYNE1_ENST00000341594.5_Missense_Mutation_p.S1683L|SYNE1_ENST00000265368.4_Missense_Mutation_p.S1613L|SYNE1_ENST00000448038.1_Missense_Mutation_p.S1620L	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1613					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GGCACTGGCTGAGAAGGCAGT	0.562000										HNSCC(10;0.0054)			38	55					0	0	1	0	0
ESF1	51575	broad.mit.edu	37	20	13740459	13740459	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr20:13740459T>C	ENST00000202816.1	-	9	1815	c.1708A>G	c.(1708-1710)Aaa>Gaa	p.K570E		NM_001276380.1|NM_016649.3	NP_001263309.1|NP_057733.2	Q9H501	ESF1_HUMAN	ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)	570	Lys-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|nucleoplasm				endometrium(3)|kidney(5)|large_intestine(8)|lung(11)|ovary(2)|skin(1)|stomach(1)	31						TTCTGACTTTTCTTTGTTTTC	0.323000													19	27					0	0	1	0	0
UBE2J1	51465	broad.mit.edu	37	6	90045138	90045138	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr6:90045138G>C	ENST00000435041.2	-	6	719	c.441C>G	c.(439-441)ttC>ttG	p.F147L		NM_016021.2	NP_057105.2	Q9Y385	UB2J1_HUMAN	ubiquitin-conjugating enzyme E2, J1	147						endoplasmic reticulum membrane|integral to membrane	ATP binding|ubiquitin-protein ligase activity			NS(1)|breast(2)|kidney(1)|large_intestine(2)|lung(11)|stomach(1)	18		all_cancers(76;1.65e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;2.5e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0139)		CTTCACAACAGAAATCTTGTG	0.373000													27	31					0	0	1	0	0
XDH	7498	broad.mit.edu	37	2	31591409	31591409	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr2:31591409C>T	ENST00000379416.3	-	19	2146	c.2098G>A	c.(2098-2100)Gag>Aag	p.E700K		NM_000379.3	NP_000370.2	P47989	XDH_HUMAN	xanthine dehydrogenase	700					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(31)|ovary(1)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(1)	74	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	TCAGTTACCTCAATTGTGATA	0.522000													15	26					0	0	1	0	0
MTPAP	55149	broad.mit.edu	37	10	30625885	30625885	+	Silent	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr10:30625885G>A	ENST00000358107.4	-	5	1016	c.1017C>T	c.(1015-1017)ctC>ctT	p.L339L	MTPAP_ENST00000263063.4_Silent_p.L209L|MTPAP_ENST00000488290.1_5'UTR			Q9NVV4	PAPD1_HUMAN	mitochondrial poly(A) polymerase	209					cell death|histone mRNA catabolic process|mRNA polyadenylation|transcription, DNA-dependent	mitochondrion	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|protein homodimerization activity|RNA binding|UTP binding			breast(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	33						GAGAACAGGTGAGATATCGGA	0.458000													88	83					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135427062	135427062	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chrX:135427062G>C	ENST00000394143.1	+	6	1488	c.1197G>C	c.(1195-1197)aaG>aaC	p.K399N	GPR112_ENST00000287534.4_Missense_Mutation_p.K336N|GPR112_ENST00000394141.1_Missense_Mutation_p.K194N|GPR112_ENST00000412101.1_Missense_Mutation_p.K194N|GPR112_ENST00000370652.1_Missense_Mutation_p.K399N	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	399					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					CTGTTACGAAGACAACATCTT	0.383000													41	6					0	0	1	0	0
TBX19	9095	broad.mit.edu	37	1	168260524	168260524	+	Silent	SNP	C	C	T	rs148222296		TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr1:168260524C>T	ENST00000367821.3	+	2	381	c.330C>T	c.(328-330)ccC>ccT	p.P110P		NM_005149.2	NP_005140.1	O60806	TBX19_HUMAN	T-box 19	110					anatomical structure morphogenesis	nucleus	DNA binding			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|liver(1)|lung(11)|prostate(2)|skin(2)|urinary_tract(1)	34	all_hematologic(923;0.215)					AATGGGTGCCCGCTGGCAAGC	0.597000													53	164					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179616692	179616692	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr2:179616692C>G	ENST00000360870.5	-	46	10657	c.10435G>C	c.(10435-10437)Gac>Cac	p.D3479H	TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000589042.1_Intron|TTN_ENST00000342992.6_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Intron|TTN-AS1_ENST00000590773.1_RNA	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	3484							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GATTTGTGGTCTATGTCTTCA	0.368000													93	75					0	0	1	0	0
LRRC37A16P	651250	broad.mit.edu	37	17	66126728	66126728	+	RNA	SNP	G	G	C			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr17:66126728G>C	ENST00000590019.1	-	0	298																											GTTTAATTCAGAAGTATCTCT	0.428000													2	1					0	0	1	0	0
NGEF	25791	broad.mit.edu	37	2	233756125	233756125	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr2:233756125G>C	ENST00000264051.3	-	8	1493	c.1215C>G	c.(1213-1215)ttC>ttG	p.F405L	NGEF_ENST00000373552.4_Missense_Mutation_p.F313L|NGEF_ENST00000539537.1_Missense_Mutation_p.F128L	NM_019850.2	NP_062824.2	Q8N5V2	NGEF_HUMAN	neuronal guanine nucleotide exchange factor	405	DH.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|growth cone|plasma membrane	Rho guanyl-nucleotide exchange factor activity			central_nervous_system(4)|endometrium(8)|kidney(2)|large_intestine(3)|lung(10)|ovary(3)|pancreas(1)|skin(4)	35		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.00793)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;8.65e-17)|BRCA - Breast invasive adenocarcinoma(100;0.00037)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(119;0.00984)|GBM - Glioblastoma multiforme(43;0.0604)		GGAAGGAGGAGAAGGGCAGCC	0.627000													16	41					0	0	1	0	0
PTPN1	5770	broad.mit.edu	37	20	49196427	49196427	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr20:49196427G>A	ENST00000371621.3	+	8	1226	c.1052G>A	c.(1051-1053)gGa>gAa	p.G351E	PTPN1_ENST00000541713.1_Missense_Mutation_p.G278E	NM_001278618.1|NM_002827.2	NP_001265547.1|NP_002818.1	P18031	PTN1_HUMAN	protein tyrosine phosphatase, non-receptor type 1	351					blood coagulation|interferon-gamma-mediated signaling pathway|negative regulation of insulin receptor signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytosol|endoplasmic reticulum membrane	protein tyrosine phosphatase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|skin(2)	16		Lung NSC(126;0.163)			Clodronate(DB00720)|Tiludronate(DB01133)	GAAGAAAAAGGAAGCCCCTTA	0.498000											OREG0026029	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	43					0	0	1	0	0
FAM178A	55719	broad.mit.edu	37	10	102707556	102707556	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr10:102707556G>C	ENST00000238961.4	+	15	3614	c.3072G>C	c.(3070-3072)aaG>aaC	p.K1024N	FAM178A_ENST00000370269.3_Missense_Mutation_p.K1024N	NM_018121.3	NP_060591.3	Q8IX21	F178A_HUMAN	family with sequence similarity 178, member A																		TTATTTCAAAGCTTTTGGATG	0.308000													28	70					0	0	1	0	0
DCUN1D3	123879	broad.mit.edu	37	16	20871597	20871597	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr16:20871597C>A	ENST00000324344.4	-	3	811	c.526G>T	c.(526-528)Gag>Tag	p.E176*	DCUN1D3_ENST00000563934.1_Nonsense_Mutation_p.E176*|ERI2_ENST00000564349.1_Intron	NM_173475.2	NP_775746.1	Q8IWE4	DCNL3_HUMAN	DCN1, defective in cullin neddylation 1, domain containing 3		DCUN1.				negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|positive regulation of apoptosis|response to gamma radiation|response to UV-C	perinuclear region of cytoplasm				NS(2)|breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(3)|ovary(2)	14				GBM - Glioblastoma multiforme(48;0.249)		AATTTATCCTCTTGTTTGGCT	0.478000													33	51					4.74835e-14	5.06112e-14	1	1	0
NAV1	89796	broad.mit.edu	37	1	201750418	201750418	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr1:201750418G>C	ENST00000367296.4	+	5	2064	c.1644G>C	c.(1642-1644)caG>caC	p.Q548H	IPO9-AS1_ENST00000413035.1_RNA|NAV1_ENST00000367297.4_Missense_Mutation_p.Q548H|NAV1_ENST00000367295.1_Missense_Mutation_p.Q157H|NAV1_ENST00000295624.6_Missense_Mutation_p.Q548H|NAV1_ENST00000367302.1_Missense_Mutation_p.Q561H|NAV1_ENST00000367300.3_Missense_Mutation_p.Q548H	NM_020443.4	NP_065176.3	Q8NEY1	NAV1_HUMAN	neuron navigator 1	548					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			breast(5)|central_nervous_system(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(10)|lung(29)|ovary(4)|prostate(3)|skin(1)|stomach(2)	70						ACACAGCCCAGAGTGCCCTCA	0.527000													5	9					0	0	1	0	0
SEMA6D	80031	broad.mit.edu	37	15	48056217	48056217	+	Silent	SNP	C	C	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr15:48056217C>A	ENST00000316364.5	+	10	1357	c.918C>A	c.(916-918)atC>atA	p.I306I	SEMA6D_ENST00000536845.2_Silent_p.I306I|SEMA6D_ENST00000389425.3_Silent_p.I306I|SEMA6D_ENST00000537942.1_Silent_p.I306I|SEMA6D_ENST00000355997.3_Silent_p.I306I|SEMA6D_ENST00000354744.4_Silent_p.I306I|SEMA6D_ENST00000389428.3_Silent_p.I306I|SEMA6D_ENST00000389433.2_Silent_p.I306I|SEMA6D_ENST00000558816.1_Silent_p.I306I|SEMA6D_ENST00000558014.1_Silent_p.I306I|SEMA6D_ENST00000389432.2_Silent_p.I306I|SEMA6D_ENST00000358066.4_Silent_p.I306I	NM_153618.1	NP_705871.1	Q8NFY4	SEM6D_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	306	Sema.				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			biliary_tract(1)|breast(4)|endometrium(4)|kidney(5)|large_intestine(10)|lung(42)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	77		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		TAATACAAATCAATGGCATCC	0.468000													23	3					1.9806e-07	2.05566e-07	1	1	0
ABCB8	11194	broad.mit.edu	37	7	150742322	150742322	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr7:150742322G>C	ENST00000358849.4	+	16	2136	c.2043G>C	c.(2041-2043)aaG>aaC	p.K681N	ABCB8_ENST00000297504.6_Missense_Mutation_p.K698N|ABCB8_ENST00000356058.4_3'UTR|ABCB8_ENST00000498578.1_Missense_Mutation_p.K656N|ABCB8_ENST00000542328.1_Missense_Mutation_p.K593N	NM_001282291.1|NM_001282293.1|NM_007188.3	NP_001269220.1|NP_001269222.1|NP_009119.2	Q9NUT2	ABCB8_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 8	698	ABC transporter.					ATP-binding cassette (ABC) transporter complex|integral to membrane|membrane fraction|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	26			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AGCTCCTGAAGAAAGGCGGGC	0.637000													15	39					0	0	1	0	0
ERCC6-PGBD3	101243544	broad.mit.edu	37	10	50724554	50724554	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr10:50724554C>T	ENST00000515869.1	-	6	2131	c.2011G>A	c.(2011-2013)Gaa>Aaa	p.E671K	PGBD3_ENST00000603152.1_Missense_Mutation_p.E671K|PGBD3_ENST00000374127.3_Missense_Mutation_p.E203K|ERCC6_ENST00000355832.5_Intron|ERCC6-PGBD3_ENST00000447839.2_Missense_Mutation_p.E671K|PGBD3_ENST00000508005.2_Missense_Mutation_p.E203K	NM_001277059.1	NP_001263988.1																					GTTCTTTGTTCCCAAAACATA	0.388000													18	66					0	0	1	0	0
CLTA	1211	broad.mit.edu	37	9	36191104	36191104	+	Silent	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr9:36191104C>T	ENST00000433436.2	+	1	252	c.51C>T	c.(49-51)ccC>ccT	p.P17P	CLTA_ENST00000345519.5_Silent_p.P17P|CLTA_ENST00000538225.1_Silent_p.P17P|CLTA_ENST00000396603.2_Silent_p.P17P|CLTA_ENST00000540080.1_Silent_p.P17P|CLTA_ENST00000470744.1_Silent_p.P17P|CLTA_ENST00000242285.6_Silent_p.P17P|CLTA_ENST00000466396.1_Silent_p.P17P	NM_007096.3	NP_009027.1	P09496	CLCA_HUMAN	clathrin, light chain A	17					axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|cytosol	structural molecule activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(1)	6			STAD - Stomach adenocarcinoma(86;0.228)			CTGGCGGTCCCGCGCTGGGGA	0.687000													9	14					0	0	1	0	0
USP28	57646	broad.mit.edu	37	11	113711387	113711387	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr11:113711387C>G	ENST00000003302.4	-	5	535	c.467G>C	c.(466-468)aGa>aCa	p.R156T	USP28_ENST00000542033.1_5'UTR|USP28_ENST00000537706.1_Missense_Mutation_p.R156T|USP28_ENST00000545540.1_Missense_Mutation_p.R31T|USP28_ENST00000260188.5_Missense_Mutation_p.R156T	NM_020886.2	NP_065937.1	Q96RU2	UBP28_HUMAN	ubiquitin specific peptidase 28	156					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(4)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(12)|lung(24)|ovary(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	59		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)		ACCATCAACTCTCCTCCAGTC	0.413000													19	27					0	0	1	0	0
PURA	5813	broad.mit.edu	37	5	139494679	139494679	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr5:139494679G>T	ENST00000331327.3	+	1	972	c.913G>T	c.(913-915)Gag>Tag	p.E305*		NM_005859.4	NP_005850.1	Q00577	PURA_HUMAN	purine-rich element binding protein A	305	Gln/Glu-rich (part of the transcriptional activation domain).				DNA unwinding involved in replication|DNA-dependent DNA replication initiation	DNA replication factor A complex	double-stranded telomeric DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|single-stranded DNA binding|transcription factor binding			central_nervous_system(1)|lung(2)|ovary(1)|prostate(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			gcagcaggaggagACCGCCGC	0.547000													7	20					8.12818e-05	8.31504e-05	1	1	0
NCOA1	8648	broad.mit.edu	37	2	24896300	24896300	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr2:24896300G>A	ENST00000405141.1	+	8	1033	c.322G>A	c.(322-324)Gaa>Aaa	p.E108K	NCOA1_ENST00000406961.1_Missense_Mutation_p.E108K|NCOA1_ENST00000395856.3_Missense_Mutation_p.E108K|NCOA1_ENST00000538539.1_Missense_Mutation_p.E108K|NCOA1_ENST00000407230.1_5'UTR|NCOA1_ENST00000288599.5_Missense_Mutation_p.E108K|NCOA1_ENST00000348332.3_Missense_Mutation_p.E108K			Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1	108									PAX3/NCOA1(8)	breast(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(26)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	53	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGGAGTGATAGAAAAGGAATC	0.338000			T	PAX3	alveolar rhadomyosarcoma								30	43					0	0	1	0	0
AGO4	192670	broad.mit.edu	37	1	36307064	36307064	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr1:36307064G>C	ENST00000373210.3	+	14	2268	c.2023G>C	c.(2023-2025)Gag>Cag	p.E675Q		NM_017629.3	NP_060099.2			argonaute RISC catalytic component 4																		AGGGGTATCTGAGGGACAAAT	0.502000													28	39					0	0	1	0	0
TUB	7275	broad.mit.edu	37	11	8060557	8060557	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr11:8060557G>A	ENST00000305253.4	+	1	378	c.137G>A	c.(136-138)cGg>cAg	p.R46Q	RP11-236J17.6_ENST00000528151.1_RNA|RP11-236J17.6_ENST00000526646.1_RNA|TUB_ENST00000534099.1_Intron	NM_003320.4	NP_003311.2	P50607	TUB_HUMAN	tubby bipartite transcription factor	0					phagocytosis|positive regulation of phagocytosis|response to stimulus	cytoplasm|extracellular region|nucleus|plasma membrane				breast(1)|cervix(1)|endometrium(9)|large_intestine(7)|lung(5)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	26		all_lung(207;6.91e-20)|Lung NSC(207;3.36e-17)		Epithelial(150;1.69e-62)|BRCA - Breast invasive adenocarcinoma(625;8.54e-06)|LUSC - Lung squamous cell carcinoma(625;0.000184)		CCCCTGAAACGGGGCCACCGA	0.572000													31	20					0	0	1	0	0
ZNF23	7571	broad.mit.edu	37	16	71512902	71512902	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr16:71512902C>T	ENST00000561908.1	-	4	542	c.40G>A	c.(40-42)Gtg>Atg	p.V14M	ZNF19_ENST00000567225.1_Missense_Mutation_p.V14M|ZNF19_ENST00000565637.1_De_novo_Start_InFrame|ZNF19_ENST00000564230.1_Missense_Mutation_p.V14M|ZNF19_ENST00000288177.5_Missense_Mutation_p.V14M|ZNF19_ENST00000565100.2_Intron																							TCGAAGGTCACCATCTCCTAA	0.557000													18	23					0	0	1	0	0
LRRC37A4P	55073	broad.mit.edu	37	17	43580838	43580838	+	RNA	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr17:43580838C>T	ENST00000253803.2	+	0	213																											gcaaggacctcagcagcggtt	0.587000													19	24					0	0	1	0	0
ANO8	57719	broad.mit.edu	37	19	17436077	17436077	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr19:17436077C>T	ENST00000159087.4	-	17	2938	c.2780G>A	c.(2779-2781)cGa>cAa	p.R927Q		NM_020959.2	NP_066010.1	Q9HCE9	ANO8_HUMAN	anoctamin 8	927						chloride channel complex	chloride channel activity			autonomic_ganglia(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|ovary(4)|pancreas(1)|prostate(2)|urinary_tract(3)	27						CGCCTCCTCTCGGCCACCAGA	0.706000													18	14					0	0	1	0	0
SDF2L1	23753	broad.mit.edu	37	22	21997180	21997180	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr22:21997180G>T	ENST00000248958.4	+	2	293	c.217G>T	c.(217-219)Gag>Tag	p.E73*		NM_022044.2	NP_071327.2	Q9HCN8	SDF2L_HUMAN	stromal cell-derived factor 2-like 1	73	MIR 1.					endoplasmic reticulum lumen|membrane				prostate(1)	1	Colorectal(54;0.105)					GACCGGCGTAGAGGCGTCGGA	0.726000													4	1					0.184627	0.184627	1	1	0
LCP2	3937	broad.mit.edu	37	5	169679455	169679455	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr5:169679455G>C	ENST00000046794.5	-	19	1921	c.1306C>G	c.(1306-1308)Ctt>Gtt	p.L436V	LCP2_ENST00000521416.1_Missense_Mutation_p.L231V	NM_005565.3	NP_005556.1	Q13094	LCP2_HUMAN	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	436	SH2.				immune response|platelet activation|T cell receptor signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway	cytosol	protein binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)	23	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0109)|all_neural(177;0.0146)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	OV - Ovarian serous cystadenocarcinoma(192;0.247)		ATCTTTCTAAGAGCAGCTTCT	0.328000													7	4					0	0	1	0	0
EPB41L4B	54566	broad.mit.edu	37	9	111947821	111947821	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr9:111947821A>G	ENST00000374566.3	-	23	2883	c.2366T>C	c.(2365-2367)aTg>aCg	p.M789T		NM_019114.3	NP_061987.3	Q9H329	E41LB_HUMAN	erythrocyte membrane protein band 4.1 like 4B	789						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|structural constituent of cytoskeleton			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						CTCTTCCTTCATGGGGAGAGA	0.617000													6	39					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49419968	49419968	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr12:49419968G>A	ENST00000301067.7	-	48	15780	c.15781C>T	c.(15781-15783)Cag>Tag	p.Q5261*		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		TGCTCACCCTGGGGAGAGGCG	0.507000													25	38					0	0	1	0	0
RFX5	5993	broad.mit.edu	37	1	151318681	151318681	+	Splice_Site	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr1:151318681G>A	ENST00000290524.4	-	3	294	c.116C>T	c.(115-117)tCc>tTc	p.S39F	RFX5_ENST00000368870.2_Splice_Site_p.S39F|RFX5_ENST00000478564.1_5'UTR|RFX5_ENST00000452513.2_Splice_Site_p.S39F|RFX5_ENST00000452671.2_Splice_Site_p.S39F	NM_000449.3|NM_001025603.1	NP_000440.1|NP_001020774.1	P48382	RFX5_HUMAN	regulatory factor X, 5 (influences HLA class II expression)	39	N-terminal domain.					nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			endometrium(3)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	20	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			GAGTACTTACGAAATGGTACC	0.557000													5	297					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189874904	189874904	+	Splice_Site	SNP	G	G	C			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr2:189874904G>C	ENST00000304636.3	+	49	3994	c.3824G>C	c.(3823-3825)gGa>gCa	p.G1275A	COL3A1_ENST00000317840.5_Splice_Site_p.G972A	NM_000090.3	NP_000081	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	1275	Fibrillar collagen NC1.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	GACTATTCAGGAGAATACTGG	0.358000													31	27					0	0	1	0	0
CCNT1	904	broad.mit.edu	37	12	49087306	49087306	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr12:49087306G>C	ENST00000261900.3	-	9	1913	c.1691C>G	c.(1690-1692)tCt>tGt	p.S564C		NM_001240.3	NP_001231.2	O60563	CCNT1_HUMAN	cyclin T1	564	Ser-rich.				cell cycle|cell division|interspecies interaction between organisms|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	DNA binding|protein kinase binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(3)|skin(2)	27						AGAGGAAAAAGAACTAGACAA	0.453000													52	66					0	0	1	0	0
MCM3AP	8888	broad.mit.edu	37	21	47666548	47666548	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr21:47666548C>G	ENST00000397708.1	-	22	4797	c.4543G>C	c.(4543-4545)Gaa>Caa	p.E1515Q	MCM3AP_ENST00000291688.1_Missense_Mutation_p.E1515Q|MCM3AP-AS1_ENST00000414659.1_RNA|MCM3AP-AS1_ENST00000590829.1_RNA|MCM3AP-AS1_ENST00000455567.1_RNA|MCM3AP_ENST00000467026.1_5'UTR			O60318	MCM3A_HUMAN	minichromosome maintenance complex component 3 associated protein	1515					DNA replication|protein import into nucleus	cytosol|nucleus	DNA binding|nucleotide binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(10)|kidney(5)|large_intestine(17)|lung(24)|ovary(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	72	Breast(49;0.112)					AAACCATCTTCTACTTCCTTC	0.547000													93	105					0	0	1	0	0
HIP1	3092	broad.mit.edu	37	7	75203084	75203084	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr7:75203084G>T	ENST00000336926.6	-	8	753	c.727C>A	c.(727-729)Ctc>Atc	p.L243I	HIP1_ENST00000434438.2_Missense_Mutation_p.L243I	NM_005338.5	NP_005329.3	O00291	HIP1_HUMAN	huntingtin interacting protein 1	243					activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			breast(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(25)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51						AGTTTGAAGAGAAGCTTGACA	0.582000			T	PDGFRB	CMML								32	15					3.03874e-20	3.27816e-20	1	1	0
CERK	64781	broad.mit.edu	37	22	47116874	47116874	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr22:47116874C>T	ENST00000216264.8	-	2	293	c.181G>A	c.(181-183)Gag>Aag	p.E61K	CERK_ENST00000541677.1_5'UTR	NM_022766.5	NP_073603.2	Q8TCT0	CERK1_HUMAN	ceramide kinase	61	Required for binding to sulfatide and phosphoinositides.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|ceramide metabolic process	integral to membrane of membrane fraction|membrane|nucleus	ATP binding|ceramide kinase activity|diacylglycerol kinase activity|magnesium ion binding			cervix(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(1)|prostate(2)|skin(2)	20		Breast(42;0.00571)|Ovarian(80;0.00965)|all_neural(38;0.0416)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)|BRCA - Breast invasive adenocarcinoma(115;0.171)		TCTGTTTCCTCAACGGCGATG	0.448000													93	125					0	0	1	0	0
HDAC3	8841	broad.mit.edu	37	5	141016334	141016334	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr5:141016334G>C	ENST00000305264.3	-	1	103	c.24C>G	c.(22-24)ttC>ttG	p.F8L		NM_003883.3	NP_003874.2	O15379	HDAC3_HUMAN	histone deacetylase 3	8	Histone deacetylase.				anti-apoptosis|cellular lipid metabolic process|negative regulation of cell cycle|negative regulation of JNK cascade|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|spindle assembly|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|spindle microtubule|transcriptional repressor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|transcription corepressor activity|transcription factor binding			endometrium(1)|large_intestine(2)|lung(3)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	13			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Vorinostat(DB02546)	CGGGGTCGTAGAAATAGGCCA	0.692000													56	33					0	0	1	0	0
LACE1	246269	broad.mit.edu	37	6	108645138	108645138	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr6:108645138C>G	ENST00000368977.4	+	2	435	c.249C>G	c.(247-249)atC>atG	p.I83M		NM_145315.3	NP_660358.2	Q8WV93	LACE1_HUMAN	lactation elevated 1	83							ATP binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(4)|upper_aerodigestive_tract(1)	15		all_cancers(87;1.5e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;6.79e-05)|Colorectal(196;0.0294)|all_lung(197;0.0486)|Lung SC(18;0.152)		BRCA - Breast invasive adenocarcinoma(108;0.00179)|Epithelial(106;0.0024)|all cancers(137;0.00379)|OV - Ovarian serous cystadenocarcinoma(136;0.0118)		ATTTTCTGATCAAAGCTCATG	0.428000													58	67					0	0	1	0	0
TRPC4	7223	broad.mit.edu	37	13	38229388	38229388	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr13:38229388G>A	ENST00000379705.3	-	7	2578	c.1721C>T	c.(1720-1722)tCa>tTa	p.S574L	TRPC4_ENST00000447043.1_Missense_Mutation_p.S574L|TRPC4_ENST00000379679.1_Missense_Mutation_p.S401L|TRPC4_ENST00000379681.3_Missense_Mutation_p.S574L|TRPC4_ENST00000338947.5_Missense_Mutation_p.S401L|TRPC4_ENST00000379673.2_Missense_Mutation_p.S574L|TRPC4_ENST00000358477.2_Missense_Mutation_p.S574L|TRPC4_ENST00000426868.2_3'UTR|TRPC4_ENST00000355779.2_Missense_Mutation_p.S574L			Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel, subfamily C, member 4	574					axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			NS(2)|breast(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(26)|lung(30)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	83				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		CCCAAATATTGACCAAAACAG	0.338000													28	23					0	0	1	0	0
POLL	27343	broad.mit.edu	37	10	103343316	103343316	+	Silent	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr10:103343316G>A	ENST00000370162.3	-	6	1508	c.1014C>T	c.(1012-1014)ttC>ttT	p.F338F	POLL_ENST00000436284.2_3'UTR|POLL_ENST00000339310.3_Silent_p.F61F|DPCD_ENST00000470165.1_Intron|POLL_ENST00000456836.2_Silent_p.F75F|POLL_ENST00000370158.3_Silent_p.F63F|POLL_ENST00000370169.1_Silent_p.F338F|POLL_ENST00000370172.1_Silent_p.F250F|POLL_ENST00000299206.4_Silent_p.F338F|DPCD_ENST00000416979.2_Intron	NM_001174084.1|NM_001174085.1|NM_013274.3	NP_001167555.1|NP_001167556.1|NP_037406.1	Q9UGP5	DPOLL_HUMAN	polymerase (DNA directed), lambda	338					DNA replication|nucleotide-excision repair|somatic hypermutation of immunoglobulin genes	nucleus	DNA binding|DNA-directed DNA polymerase activity|lyase activity|metal ion binding			biliary_tract(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(2)|lung(7)|upper_aerodigestive_tract(2)	19		Colorectal(252;0.234)		Epithelial(162;1.55e-08)|all cancers(201;6.64e-07)		AGATGTTGGAGAAGAGCTCCA	0.542000								DNA polymerases (catalytic subunits)					28	18					0	0	1	0	0
ADIPOQ	9370	broad.mit.edu	37	3	186572145	186572145	+	Silent	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr3:186572145C>T	ENST00000412955.2	+	3	528	c.387C>T	c.(385-387)ccC>ccT	p.P129P	ADIPOQ_ENST00000320741.2_Silent_p.P129P|ADIPOQ-AS1_ENST00000422718.1_RNA|ADIPOQ_ENST00000444204.2_Silent_p.P129P			Q15848	ADIPO_HUMAN	adiponectin, C1Q and collagen domain containing	129	C1q.				brown fat cell differentiation|cellular response to drug|cellular response to insulin stimulus|detection of oxidative stress|fatty acid beta-oxidation|generation of precursor metabolites and energy|glucose homeostasis|glucose metabolic process|low-density lipoprotein particle clearance|negative regulation of blood pressure|negative regulation of DNA biosynthetic process|negative regulation of ERK1 and ERK2 cascade|negative regulation of eukaryotic cell surface binding|negative regulation of fat cell differentiation|negative regulation of gluconeogenesis|negative regulation of granulocyte differentiation|negative regulation of heterotypic cell-cell adhesion|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of inflammatory response|negative regulation of intracellular protein transport|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|negative regulation of macrophage differentiation|negative regulation of MAP kinase activity|negative regulation of phagocytosis|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein autophosphorylation|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell proliferation|negative regulation of synaptic transmission|negative regulation of transcription, DNA-dependent|negative regulation of tumor necrosis factor production|negative regulation of tumor necrosis factor-mediated signaling pathway|positive regulation of cAMP-dependent protein kinase activity|positive regulation of cholesterol efflux|positive regulation of fatty acid metabolic process|positive regulation of glucose import|positive regulation of glycogen (starch) synthase activity|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 production|positive regulation of metanephric glomerular visceral epithelial cell development|positive regulation of monocyte chemotactic protein-1 production|positive regulation of myeloid cell apoptosis|positive regulation of protein kinase A signaling cascade|positive regulation of renal albumin absorption|protein homooligomerization|protein localization in plasma membrane|response to glucose stimulus|response to tumor necrosis factor	collagen|endoplasmic reticulum|extracellular space	cytokine activity|eukaryotic cell surface binding|hormone activity|protein homodimerization activity			breast(1)|endometrium(2)|large_intestine(4)|lung(6)|ovary(1)|skin(2)	16	all_cancers(143;1.2e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.47e-19)	GBM - Glioblastoma multiforme(93;0.0776)		CCAACATGCCCATTCGCTTTA	0.473000													13	64					0	0	1	0	0
HIST2H2AC	8338	broad.mit.edu	37	1	149858692	149858692	+	Silent	SNP	C	C	G			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr1:149858692C>G	ENST00000331380.2	+	1	168	c.168C>G	c.(166-168)ctC>ctG	p.L56L		NM_003517.2	NP_003508.1	Q16777	H2A2C_HUMAN	histone cluster 2, H2ac	56					nucleosome assembly	nucleosome|nucleus	DNA binding	p.L56L(2)		NS(1)|breast(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(11)|ovary(1)|skin(1)	20	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			CGGCGGTCCTCGAGTACCTGA	0.687000													37	49					0	0	1	0	0
PTPN1	5770	broad.mit.edu	37	20	49195795	49195795	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr20:49195795G>A	ENST00000371621.3	+	7	967	c.793G>A	c.(793-795)Gac>Aac	p.D265N	PTPN1_ENST00000541713.1_Missense_Mutation_p.D192N	NM_001278618.1|NM_002827.2	NP_001265547.1|NP_002818.1	P18031	PTN1_HUMAN	protein tyrosine phosphatase, non-receptor type 1	265	Tyrosine-protein phosphatase.				blood coagulation|interferon-gamma-mediated signaling pathway|negative regulation of insulin receptor signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytosol|endoplasmic reticulum membrane	protein tyrosine phosphatase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|skin(2)	16		Lung NSC(126;0.163)			Clodronate(DB00720)|Tiludronate(DB01133)	CCAGACAGCCGACCAGCTGCG	0.502000													62	92					0	0	1	0	0
VPS13B	157680	broad.mit.edu	37	8	100160158	100160158	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr8:100160158C>G	ENST00000395996.1	+	14	2044	c.1933C>G	c.(1933-1935)Ctc>Gtc	p.L645V	VPS13B_ENST00000355155.1_Missense_Mutation_p.L645V|VPS13B_ENST00000358544.2_Missense_Mutation_p.L645V|VPS13B_ENST00000357162.2_Missense_Mutation_p.L645V			Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	645					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			AAGTGTTACTCTCCTCAAATG	0.358000													53	71					0	0	1	0	0
C7orf50	84310	broad.mit.edu	37	7	1166985	1166985	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr7:1166985C>G	ENST00000397098.3	-	2	963	c.37G>C	c.(37-39)Gag>Cag	p.E13Q	C7orf50_ENST00000488073.1_5'UTR|C7orf50_ENST00000357429.6_Missense_Mutation_p.E13Q|C7orf50_ENST00000397100.2_Missense_Mutation_p.E13Q			Q9BRJ6	CG050_HUMAN	chromosome 7 open reading frame 50	13							protein binding			kidney(1)|large_intestine(1)|lung(3)|ovary(1)	6		Ovarian(82;0.0779)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0216)|OV - Ovarian serous cystadenocarcinoma(56;1.3e-15)		TTCTTTTTCTCTGTCACTTCA	0.483000													20	18					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25457288	25457288	+	RNA	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr15:25457288G>A	ENST00000424208.1	+	0	2534				SNHG14_ENST00000424333.1_RNA|SNHG14_ENST00000450809.1_RNA	NR_003305.1																						TTCTGCCAAGGGGGGGCCTCC	0.582000													3	2					0	0	1	0	0
GGT3P	2679	broad.mit.edu	37	22	18769145	18769145	+	RNA	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr22:18769145G>A	ENST00000412448.1	-	0	1141																											TGAGGCTGCCGTTGTAGAAGG	0.612000													3	15					0	0	1	0	0
YIF1B	90522	broad.mit.edu	37	19	38800062	38800062	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr19:38800062C>T	ENST00000392124.3	-	1	501	c.187G>A	c.(187-189)Gag>Aag	p.E63K	YIF1B_ENST00000329420.8_Missense_Mutation_p.E79K|YIF1B_ENST00000339413.6_Missense_Mutation_p.E94K|YIF1B_ENST00000592694.1_Missense_Mutation_p.E63K|YIF1B_ENST00000587361.1_5'UTR|YIF1B_ENST00000337679.8_Missense_Mutation_p.E91K|YIF1B_ENST00000591784.1_Missense_Mutation_p.E63K|YIF1B_ENST00000592246.1_Missense_Mutation_p.E63K|YIF1B_ENST00000591755.1_Missense_Mutation_p.E91K	NM_033557.3	NP_291035.1	Q5BJH7	YIF1B_HUMAN	Yip1 interacting factor homolog B (S. cerevisiae)	94						integral to membrane				central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(2)|prostate(1)	10	all_cancers(60;1.07e-06)		Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			TCCACCAGCTCCTTGCCCTGC	0.657000													7	21					0	0	1	0	0
LAIR2	3904	broad.mit.edu	37	19	55019131	55019131	+	Silent	SNP	G	G	A	rs142699455		TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr19:55019131G>A	ENST00000301202.2	+	3	218	c.96G>A	c.(94-96)tcG>tcA	p.S32S	LAIR2_ENST00000351841.2_Silent_p.S32S	NM_002288.4	NP_002279.2	Q6ISS4	LAIR2_HUMAN	leukocyte-associated immunoglobulin-like receptor 2	32	Ig-like C2-type.					extracellular region	receptor activity			central_nervous_system(1)|kidney(3)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(1)	18	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0967)		CCTCCATCTCGGCTGAGCCAG	0.577000													74	69					0	0	1	0	0
CCIN	881	broad.mit.edu	37	9	36170889	36170889	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr9:36170889G>C	ENST00000335119.2	+	1	1501	c.1390G>C	c.(1390-1392)Gag>Cag	p.E464Q		NM_005893.2	NP_005884.2	Q13939	CALI_HUMAN	calicin	464					cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			breast(3)|endometrium(2)|large_intestine(4)|liver(2)|lung(5)|ovary(1)|skin(4)	21			STAD - Stomach adenocarcinoma(86;0.228)			CTTCCCCATTGAGTTCAACCA	0.557000													44	73					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79207580	79207580	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr4:79207580C>T	ENST00000264895.6	+	14	1861	c.1421C>T	c.(1420-1422)aCg>aTg	p.T474M	FRAS1_ENST00000325942.6_Missense_Mutation_p.T474M|FRAS1_ENST00000264899.6_Missense_Mutation_p.T474M	NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	474					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						CAGTGCTCCACGTGTACCAGT	0.572000													41	23					0	0	1	0	0
NCOA1	8648	broad.mit.edu	37	2	24896236	24896236	+	Splice_Site	SNP	G	G	C			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr2:24896236G>C	ENST00000405141.1	+	8	969	c.258G>C	c.(256-258)gaG>gaC	p.E86D	NCOA1_ENST00000406961.1_Splice_Site_p.E86D|NCOA1_ENST00000395856.3_Splice_Site_p.E86D|NCOA1_ENST00000538539.1_Splice_Site_p.E86D|NCOA1_ENST00000407230.1_5'UTR|NCOA1_ENST00000288599.5_Splice_Site_p.E86D|NCOA1_ENST00000348332.3_Splice_Site_p.E86D			Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1	86									PAX3/NCOA1(8)	breast(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(26)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	53	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTATTATAGAGAAATCAACAA	0.333000			T	PAX3	alveolar rhadomyosarcoma								17	39					0	0	1	0	0
MYO5B	4645	broad.mit.edu	37	18	47363894	47363894	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr18:47363894G>T	ENST00000285039.7	-	37	5430	c.5131C>A	c.(5131-5133)Caa>Aaa	p.Q1711K	RP11-886H22.1_ENST00000590532.2_Missense_Mutation_p.Q34K|SCARNA17_ENST00000589499.1_RNA|MYO5B_ENST00000592688.1_Missense_Mutation_p.Q281K|MYO5B_ENST00000324581.6_Missense_Mutation_p.Q826K	NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	1711	Dilute.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		TACCTGAGTTGCATGCCTGTG	0.498000													9	15					0.000442599	0.000451477	1	1	0
NHS	4810	broad.mit.edu	37	X	17750302	17750302	+	Silent	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chrX:17750302G>A	ENST00000380060.3	+	8	4949	c.4611G>A	c.(4609-4611)caG>caA	p.Q1537Q	NHS_ENST00000398097.3_Silent_p.Q1381Q	NM_198270.2	NP_938011.1	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome (congenital cataracts and dental anomalies)	1537						nucleus				breast(5)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(26)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	71	Hepatocellular(33;0.183)					AGTCCCCTCAGAGCACCGATG	0.567000													50	5					0	0	1	0	0
HECTD4	283450	broad.mit.edu	37	12	112642326	112642326	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr12:112642326C>T	ENST00000550722.1	-	53	8190	c.7795G>A	c.(7795-7797)Gaa>Aaa	p.E2599K	HECTD4_ENST00000377560.5_Missense_Mutation_p.E2573K|HECTD4_ENST00000430131.2_Missense_Mutation_p.E2323K	NM_001109662.3	NP_001103132.3			HECT domain containing E3 ubiquitin protein ligase 4																		TTGTTTGCTTCGTCTTTAATG	0.393000													28	25					0	0	1	0	0
MSI2	124540	broad.mit.edu	37	17	55335715	55335715	+	Splice_Site	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr17:55335715G>A	ENST00000284073.2	+	4	479	c.270G>A	c.(268-270)acG>acA	p.T90T	MSI2_ENST00000322684.3_Splice_Site_p.T86T|MSI2_ENST00000416426.2_Splice_Site_p.T68T	NM_138962.2	NP_620412.1	Q96DH6	MSI2H_HUMAN	musashi RNA-binding protein 2	90	RRM 1.					cytoplasm	nucleotide binding|RNA binding	p.T90T(1)|p.T86T(1)		central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|ovary(1)|pancreas(1)|skin(1)	7	Breast(9;1.78e-08)			GBM - Glioblastoma multiforme(1;0.0025)		ATTCCAAGACGGTAGGTTGCT	0.478000			T	HOXA9	CML								27	87					0	0	1	0	0
N4BP3	23138	broad.mit.edu	37	5	177548745	177548745	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr5:177548745G>A	ENST00000274605.5	+	5	1737	c.1378G>A	c.(1378-1380)Gag>Aag	p.E460K		NM_015111.1	NP_055926.1	O15049	N4BP3_HUMAN	NEDD4 binding protein 3	460						cytoplasmic vesicle membrane				breast(2)|endometrium(3)|kidney(1)|large_intestine(1)|lung(1)|skin(1)	9	all_cancers(89;0.00294)|Renal(175;0.000269)|Lung NSC(126;0.00858)|all_lung(126;0.0139)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGGAGGCAGCGAGGCCAGAGA	0.687000													12	1					0	0	1	0	0
DNAJB14	79982	broad.mit.edu	37	4	100867639	100867639	+	Silent	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr4:100867639G>A	ENST00000442697.2	-	1	244	c.90C>T	c.(88-90)ttC>ttT	p.F30F	DNAJB14_ENST00000471738.1_5'UTR	NM_001031723.2|NM_001278310.1	NP_001026893.1|NP_001265239.1	Q8TBM8	DJB14_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 14	30					protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			kidney(1)|large_intestine(2)|lung(1)|upper_aerodigestive_tract(1)	5				OV - Ovarian serous cystadenocarcinoma(123;4.59e-09)		CCTTCTGCAGGAAGCGCTGGG	0.652000													22	3					0	0	1	0	0
STAG1	10274	broad.mit.edu	37	3	136078066	136078066	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr3:136078066C>G	ENST00000383202.2	-	27	3116	c.2860G>C	c.(2860-2862)Gaa>Caa	p.E954Q	STAG1_ENST00000236698.5_Missense_Mutation_p.E954Q|STAG1_ENST00000434713.2_Missense_Mutation_p.E694Q|STAG1_ENST00000536929.1_Missense_Mutation_p.E538Q	NM_005862.2	NP_005853.2	Q8WVM7	STAG1_HUMAN	stromal antigen 1	954					cell division|chromosome segregation|mitotic metaphase/anaphase transition|mitotic prometaphase	cell junction|chromatin|chromosome, centromeric region|nucleoplasm	protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(16)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58						CGTGCCAGTTCTTTAATGCCA	0.398000													30	28					0	0	1	0	0
FBXL3	26224	broad.mit.edu	37	13	77595934	77595934	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr13:77595934G>A	ENST00000355619.5	-	2	386	c.62C>T	c.(61-63)tCc>tTc	p.S21F		NM_012158.2	NP_036290.1	Q9UKT7	FBXL3_HUMAN	F-box and leucine-rich repeat protein 3	21					regulation of circadian rhythm|rhythmic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|SCF ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(5)|urinary_tract(1)	16		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.218)		GBM - Glioblastoma multiforme(99;0.0521)		CAGTTTCTTGGATTTCTCTGC	0.383000													17	86					0	0	1	0	0
MTOR	2475	broad.mit.edu	37	1	11187752	11187752	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr1:11187752C>G	ENST00000361445.4	-	44	6221	c.6145G>C	c.(6145-6147)Gag>Cag	p.E2049Q	MTOR_ENST00000376838.1_Missense_Mutation_p.E254Q	NM_004958.3	NP_004949.1	P42345	MTOR_HUMAN	mechanistic target of rapamycin (serine/threonine kinase)	2049					cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(7)|endometrium(20)|kidney(34)|large_intestine(21)|lung(43)|ovary(9)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	149						TCCAGCACCTCAAACATGCCT	0.507000													90	85					0	0	1	0	0
CUL1	8454	broad.mit.edu	37	7	148489832	148489832	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr7:148489832G>C	ENST00000325222.4	+	17	2100	c.1821G>C	c.(1819-1821)caG>caC	p.Q607H	CUL1_ENST00000602748.1_Missense_Mutation_p.Q607H|CUL1_ENST00000409469.1_Missense_Mutation_p.Q607H	NM_003592.2	NP_003583.2	Q13616	CUL1_HUMAN	cullin 1	607					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein ubiquitination|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|nucleoplasm|SCF ubiquitin ligase complex	ubiquitin protein ligase binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(5)|large_intestine(10)|liver(2)|lung(10)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	40	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			CGACATTCCAGATGGCTATCC	0.448000													9	17					0	0	1	0	0
SEMA5A	9037	broad.mit.edu	37	5	9202183	9202183	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr5:9202183C>T	ENST00000382496.5	-	9	1481	c.816G>A	c.(814-816)atG>atA	p.M272I		NM_003966.2	NP_003957.2	Q13591	SEM5A_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	272	Sema.				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(13)|lung(40)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	81						GGCGAGCCTTCATGAATGTGG	0.527000													44	52					0	0	1	0	0
PROM2	150696	broad.mit.edu	37	2	95954741	95954741	+	Silent	SNP	G	G	C			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr2:95954741G>C	ENST00000317620.9	+	23	2635	c.2502G>C	c.(2500-2502)ctG>ctC	p.L834L	PROM2_ENST00000542147.1_Silent_p.L785L|PROM2_ENST00000317668.4_Silent_p.L834L|PROM2_ENST00000403131.2_Silent_p.L834L	NM_001165978.1	NP_001159450.1	Q8N271	PROM2_HUMAN	prominin 2	834						apical plasma membrane|basolateral plasma membrane|cilium membrane|integral to membrane|microvillus membrane				breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(12)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	32						CCCTGAAGCTGTAGGGCCTTG	0.597000													39	20					0	0	1	0	0
MYH1	4619	broad.mit.edu	37	17	10397696	10397696	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr17:10397696G>A	ENST00000226207.5	-	39	5736	c.5642C>T	c.(5641-5643)tCc>tTc	p.S1881F	CTC-297N7.11_ENST00000587182.2_RNA|RP11-799N11.1_ENST00000581304.1_RNA|RP11-799N11.1_ENST00000399342.2_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1881						muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						TCTCTTGTAGGATTTCACCTT	0.433000													43	41					0	0	1	0	0
KPNA2	3838	broad.mit.edu	37	17	66033579	66033579	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr17:66033579A>G	ENST00000537025.2	+	3	801	c.181A>G	c.(181-183)Act>Gct	p.T61A	KPNA2_ENST00000330459.3_Missense_Mutation_p.T61A			P52292	IMA2_HUMAN	karyopherin alpha 2 (RAG cohort 1, importin alpha 1)	61					DNA metabolic process|G2 phase of mitotic cell cycle|interspecies interaction between organisms|M phase specific microtubule process|NLS-bearing substrate import into nucleus|regulation of DNA recombination	cytoplasm|nuclear pore|nucleoplasm	histone deacetylase binding|nuclear localization sequence binding|protein transporter activity			breast(1)|central_nervous_system(2)|cervix(3)|endometrium(2)|kidney(2)|lung(9)|prostate(1)|urinary_tract(2)	22	all_cancers(12;1.18e-09)		BRCA - Breast invasive adenocarcinoma(8;1.03e-07)|LUSC - Lung squamous cell carcinoma(166;0.24)			TGATGATGCTACTTCTCCGCT	0.418000													72	65					0	0	1	0	0
FBXL3	26224	broad.mit.edu	37	13	77595961	77595961	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr13:77595961G>A	ENST00000355619.5	-	2	359	c.35C>T	c.(34-36)tCa>tTa	p.S12L		NM_012158.2	NP_036290.1	Q9UKT7	FBXL3_HUMAN	F-box and leucine-rich repeat protein 3	12					regulation of circadian rhythm|rhythmic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|SCF ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(5)|urinary_tract(1)	16		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.218)		GBM - Glioblastoma multiforme(99;0.0521)		TTCTTCTGATGAATTACGGTC	0.373000													24	78					0	0	1	0	0
FNBP4	23360	broad.mit.edu	37	11	47758243	47758243	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr11:47758243C>A	ENST00000263773.5	-	9	1518	c.1506G>T	c.(1504-1506)gaG>gaT	p.E502D	FNBP4_ENST00000534003.1_5'UTR	NM_015308.2	NP_056123.2	Q8N3X1	FNBP4_HUMAN	formin binding protein 4	502										NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(12)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	44						CTACTTCCATCTCTTTATCTG	0.289000													22	23					1.50039e-11	1.59444e-11	1	1	0
CROCCP2	84809	broad.mit.edu	37	1	16946437	16946437	+	RNA	SNP	C	C	T	rs2262202		TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr1:16946437C>T	ENST00000412962.1	-	0	1082																											AGCCTTCCGCCGGGCCAGCAG	0.672000													3	12					0	0	1	0	0
SLC11A1	6556	broad.mit.edu	37	2	219249071	219249071	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr2:219249071G>A	ENST00000233202.6	+	3	596	c.256G>A	c.(256-258)Gcc>Acc	p.A86T	SLC11A1_ENST00000473367.1_3'UTR|SLC11A1_ENST00000539932.1_5'UTR	NM_000578.3	NP_000569.3	P49279	NRAM1_HUMAN	solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1	86				A -> P (in Ref. 5).	activation of protein kinase activity|antigen processing and presentation of peptide antigen|cadmium ion transmembrane transport|cellular cadmium ion homeostasis|cellular iron ion homeostasis|defense response to Gram-negative bacterium|defense response to protozoan|divalent metal ion export|inflammatory response|interleukin-2 production|interleukin-3 production|iron ion transport|L-arginine import|macrophage activation|MHC class II biosynthetic process|mRNA stabilization|multicellular organismal iron ion homeostasis|negative regulation of cytokine production|nitrite transport|phagocytosis|positive regulation of dendritic cell antigen processing and presentation|positive regulation of interferon-gamma production|positive regulation of phagocytosis|positive regulation of T-helper 1 type immune response|positive regulation of transcription from RNA polymerase II promoter|respiratory burst|response to interferon-gamma|response to lipopolysaccharide|T cell cytokine production|T cell proliferation involved in immune response|vacuolar acidification|wound healing	integral to plasma membrane|late endosome membrane|lysosome|phagocytic vesicle membrane|tertiary granule membrane	manganese ion transmembrane transporter activity|metal ion:hydrogen antiporter activity|protein homodimerization activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	19		Renal(207;0.0474)		Epithelial(149;1.16e-06)|all cancers(144;0.000195)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TCAGGCTGGCGCCGTGGCGGG	0.577000													35	51					0	0	1	0	0
TSHZ1	10194	broad.mit.edu	37	18	72998746	72998746	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr18:72998746G>A	ENST00000322038.5	+	2	1833	c.1249G>A	c.(1249-1251)Gaa>Aaa	p.E417K	TSHZ1_ENST00000580243.1_Missense_Mutation_p.E462K	NM_005786.5	NP_005777.3	Q6ZSZ6	TSH1_HUMAN	teashirt zinc finger homeobox 1	462						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(11)|liver(1)|lung(14)|ovary(1)|skin(6)|upper_aerodigestive_tract(2)	42		Esophageal squamous(42;0.129)|Prostate(75;0.142)|Melanoma(33;0.211)		Colorectal(1;0.000501)|READ - Rectum adenocarcinoma(2;0.00226)|BRCA - Breast invasive adenocarcinoma(31;0.246)		CCCTGTGGTGGAAGAGAAGAT	0.627000													12	27					0	0	1	0	0
KIAA0368	23392	broad.mit.edu	37	9	114202739	114202739	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr9:114202739G>A	ENST00000259335.4	-	7	985	c.986C>T	c.(985-987)tCa>tTa	p.S329L	KIAA0368_ENST00000338205.5_Missense_Mutation_p.S151L	NM_001080398.1	NP_001073867.1			KIAA0368											NS(2)|breast(3)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(23)|prostate(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	65						TGGAGAAGCTGATTTTGATGA	0.343000													14	14					0	0	1	0	0
OFD1	8481	broad.mit.edu	37	X	13764961	13764961	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chrX:13764961A>T	ENST00000380567.1	+	9	1169	c.297A>T	c.(295-297)gaA>gaT	p.E99D	OFD1_ENST00000380550.3_Missense_Mutation_p.E239D|OFD1_ENST00000490265.1_3'UTR|OFD1_ENST00000398395.3_Missense_Mutation_p.E239D|OFD1_ENST00000340096.6_Missense_Mutation_p.E239D			O75665	OFD1_HUMAN	oral-facial-digital syndrome 1	239	LisH.				cilium movement involved in determination of left/right asymmetry|G2/M transition of mitotic cell cycle	centriole|cilium|cytosol|microtubule basal body|nuclear membrane	alpha-tubulin binding|gamma-tubulin binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	25						AAAAGTATGAAAAGGAGTTAA	0.308000													15	88					0	0	1	0	0
NCKIPSD	51517	broad.mit.edu	37	3	48716072	48716072	+	Silent	SNP	G	G	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr3:48716072G>T	ENST00000294129.2	-	12	2009	c.1890C>A	c.(1888-1890)atC>atA	p.I630I	NCKIPSD_ENST00000416649.2_Silent_p.I623I|NCKIPSD_ENST00000341520.4_Silent_p.I630I	NM_016453.2	NP_057537.1	Q9NZQ3	SPN90_HUMAN	NCK interacting protein with SH3 domain	630					cytoskeleton organization|NLS-bearing substrate import into nucleus|signal transduction	intermediate filament|nucleus	cytoskeletal protein binding|SH3 domain binding			endometrium(1)|large_intestine(3)|lung(6)|prostate(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		TGTGGTAGAAGATGGCAGCTG	0.572000													49	34					5.18031e-10	5.48867e-10	1	1	0
TMCO3	55002	broad.mit.edu	37	13	114202701	114202701	+	Silent	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr13:114202701C>T	ENST00000434316.2	+	12	2213	c.1854C>T	c.(1852-1854)gcC>gcT	p.A618A	TMCO3_ENST00000375391.1_Intron	NM_017905.4	NP_060375.4	Q6UWJ1	TMCO3_HUMAN	transmembrane and coiled-coil domains 3	618						integral to membrane	solute:hydrogen antiporter activity			NS(1)|endometrium(4)|large_intestine(9)|liver(1)|lung(8)|prostate(1)|stomach(1)	25	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0145)|all_epithelial(44;0.00286)|all_lung(25;0.0273)|Breast(118;0.0411)|Lung NSC(25;0.0983)	all cancers(43;0.0317)			CGGGGCTTGCCCAGGTCAGCG	0.637000													22	10					0	0	1	0	0
PPP2R5C	5527	broad.mit.edu	37	14	102372852	102372852	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr14:102372852G>C	ENST00000422945.2	+	12	1326	c.1230G>C	c.(1228-1230)aaG>aaC	p.K410N	PPP2R5C_ENST00000557095.1_Missense_Mutation_p.K379N|PPP2R5C_ENST00000328724.5_Missense_Mutation_p.K434N|PPP2R5C_ENST00000445439.3_Missense_Mutation_p.K379N|PPP2R5C_ENST00000350249.3_Missense_Mutation_p.K379N|PPP2R5C_ENST00000334743.5_Missense_Mutation_p.K379N	NM_001161725.1	NP_001155197.1	Q13362	2A5G_HUMAN	protein phosphatase 2, regulatory subunit B', gamma	379					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|negative regulation of cell proliferation|proteasomal ubiquitin-dependent protein catabolic process|signal transduction	chromosome, centromeric region|nucleus|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	20						GCAACTCAAAGACCCATTGGA	0.373000													45	36					0	0	1	0	0
REV1	51455	broad.mit.edu	37	2	100017760	100017760	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr2:100017760C>G	ENST00000258428.3	-	23	3928	c.3700G>C	c.(3700-3702)Gac>Cac	p.D1234H	REV1_ENST00000393445.3_Missense_Mutation_p.D1233H|EIF5B_ENST00000289371.6_3'UTR	NM_001037872.1|NM_016316.2	NP_001032961.1|NP_057400.1	Q9UBZ9	REV1_HUMAN	REV1, polymerase (DNA directed)	1234	Protein interaction domain; mediates interaction with DNA polymerase zeta.				DNA replication|error-prone translesion synthesis|response to UV	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|magnesium ion binding|protein binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(14)|lung(12)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						TGGACATTGTCAAGAATAAAG	0.398000								Direct reversal of damage					18	46					0	0	1	0	0
COL21A1	81578	broad.mit.edu	37	6	56032952	56032952	+	Silent	SNP	T	T	C			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr6:56032952T>C	ENST00000244728.5	-	6	1567	c.1170A>G	c.(1168-1170)ggA>ggG	p.G390G	COL21A1_ENST00000535941.1_Silent_p.G390G|COL21A1_ENST00000370819.1_Silent_p.G390G	NM_030820.3	NP_110447.2	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1	390	TSP N-terminal.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|prostate(2)	41	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			CAGAATATTTTCCAATTTGGG	0.318000													4	4					0	0	1	0	0
SERPINB10	5273	broad.mit.edu	37	18	61582754	61582754	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr18:61582754C>G	ENST00000238508.3	+	2	69	c.10C>G	c.(10-12)Cta>Gta	p.L4V		NM_005024.1	NP_005015.1			serpin peptidase inhibitor, clade B (ovalbumin), member 10											breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(6)|prostate(1)|skin(3)|stomach(2)	24		Esophageal squamous(42;0.131)				AATGGACTCTCTAGCAACATC	0.348000													52	33					0	0	1	0	0
SEPT9	10801	broad.mit.edu	37	17	75484920	75484920	+	Silent	SNP	C	C	G			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr17:75484920C>G	ENST00000329047.8	+	6	1994	c.1182C>G	c.(1180-1182)ctC>ctG	p.L394L	SEPT9_ENST00000431235.2_Silent_p.L248L|SEPT9_ENST00000541152.2_Silent_p.L161L|SEPT9_ENST00000588690.1_Silent_p.L248L|SEPT9_ENST00000590294.1_Silent_p.L394L|SEPT9_ENST00000427674.2_Silent_p.L248L|SEPT9_ENST00000449803.2_Silent_p.L248L|SEPT9_ENST00000591088.1_Silent_p.L161L|SEPT9_ENST00000592481.1_3'UTR|SEPT9_ENST00000423034.2_Silent_p.L405L|SEPT9_ENST00000585930.1_Silent_p.L188L|SEPT9_ENST00000592951.1_Silent_p.L161L|SEPT9_ENST00000427177.1_Silent_p.L412L|SEPT9_ENST00000427180.1_Silent_p.L300L|SEPT9_ENST00000591198.1_Silent_p.L393L	NM_006640.4	NP_006631.2	Q9UHD8	SEPT9_HUMAN	septin 9	412					cell cycle|cell division|protein heterooligomerization	microtubule|perinuclear region of cytoplasm|stress fiber	GTP binding|GTPase activity|protein binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|prostate(2)	16			BRCA - Breast invasive adenocarcinoma(99;0.153)			ACTGCTGCCTCTACTTCATCC	0.607000													21	34					0	0	1	0	0
CLDN14	23562	broad.mit.edu	37	21	37833330	37833330	+	Missense_Mutation	SNP	C	C	T	rs138008896	byFrequency	TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr21:37833330C>T	ENST00000399137.1	-	3	1530	c.664G>A	c.(664-666)Gcc>Acc	p.A222T	CLDN14_ENST00000399139.1_Missense_Mutation_p.A222T|AP000695.4_ENST00000428667.1_RNA|AP000695.6_ENST00000429588.1_RNA|CLDN14_ENST00000399135.1_Missense_Mutation_p.A222T|CLDN14_ENST00000399136.1_Missense_Mutation_p.A222T|CLDN14_ENST00000342108.2_Missense_Mutation_p.A222T	NM_144492.2	NP_652763.1	O95500	CLD14_HUMAN	claudin 14	222					calcium-independent cell-cell adhesion|protein complex assembly|tight junction assembly	endoplasmic reticulum|integral to membrane|tight junction	identical protein binding|structural molecule activity			endometrium(1)|lung(5)|skin(1)	7						ACTGAGGGGGCCCGATTGTCT	0.667000													24	24					0	0	1	0	0
PRPF4B	8899	broad.mit.edu	37	6	4041080	4041080	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr6:4041080G>C	ENST00000337659.6	+	4	1587	c.1487G>C	c.(1486-1488)aGa>aCa	p.R496T	PRPF4B_ENST00000538861.1_Missense_Mutation_p.R482T	NM_003913.4	NP_003904.3	Q13523	PRP4B_HUMAN	pre-mRNA processing factor 4B	496	Arg/Lys-rich (basic).					catalytic step 2 spliceosome	ATP binding|protein binding|protein serine/threonine kinase activity			breast(6)|endometrium(3)|large_intestine(5)|lung(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	22	Ovarian(93;0.0925)	all_hematologic(90;0.0895)				CGAAGGAGCAGAAGCAAAGTA	0.438000													38	32					0	0	1	0	0
FPR3	2359	broad.mit.edu	37	19	52327547	52327547	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr19:52327547C>G	ENST00000339223.4	+	2	725	c.546C>G	c.(544-546)ttC>ttG	p.F182L	FPR3_ENST00000595991.1_Missense_Mutation_p.F182L	NM_002030.3	NP_002021.3	P25089	FPR3_HUMAN	formyl peptide receptor 3	182					cellular component movement|chemotaxis	integral to membrane|plasma membrane	N-formyl peptide receptor activity			NS(1)|breast(3)|endometrium(3)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(3)	35						ACTTTGCATTCTGGGGTGACA	0.428000													71	60					0	0	1	0	0
CFH	3075	broad.mit.edu	37	1	196682931	196682931	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr1:196682931C>A	ENST00000367429.4	+	10	1643	c.1403C>A	c.(1402-1404)gCc>gAc	p.A468D		NM_000186.3	NP_000177.2	P08603	CFAH_HUMAN	complement factor H	468	Sushi 8.				complement activation, alternative pathway	extracellular space				NS(3)|breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(24)|lung(33)|ovary(1)|prostate(5)|skin(9)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	101						TATACATATGCCTTAAAAGAA	0.338000													23	57					1.85244e-09	1.95109e-09	1	1	0
ZBTB5	9925	broad.mit.edu	37	9	37441255	37441255	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr9:37441255G>T	ENST00000307750.4	-	2	1482	c.1294C>A	c.(1294-1296)Cca>Aca	p.P432T		NM_014872.2	NP_055687.1	O15062	ZBTB5_HUMAN	zinc finger and BTB domain containing 5	432					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(2)|prostate(1)	8				GBM - Glioblastoma multiforme(29;0.00733)|Lung(182;0.226)		GTGGTGTTTGGAATATTATCA	0.463000													26	36					5.35047e-06	5.48924e-06	1	1	0
RBM47	54502	broad.mit.edu	37	4	40440341	40440341	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr4:40440341C>G	ENST00000319592.4	-	4	1279	c.570G>C	c.(568-570)aaG>aaC	p.K190N	RBM47_ENST00000514014.1_Missense_Mutation_p.K152N|RBM47_ENST00000381795.6_Missense_Mutation_p.K190N|RBM47_ENST00000381793.2_Missense_Mutation_p.K190N|RBM47_ENST00000515809.1_Intron|RBM47_ENST00000295971.7_Missense_Mutation_p.K190N			A0AV96	RBM47_HUMAN	RNA binding motif protein 47	190	RRM 2.					nucleus	nucleotide binding|RNA binding			breast(5)|endometrium(1)|kidney(3)|large_intestine(2)|lung(9)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	29						GGTTCTTCATCTTGTCGGCCG	0.647000													22	71					0	0	1	0	0
ADAMTS9	56999	broad.mit.edu	37	3	64599121	64599121	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr3:64599121C>G	ENST00000498707.1	-	22	3596	c.3254G>C	c.(3253-3255)cGa>cCa	p.R1085P	ADAMTS9_ENST00000295903.4_Missense_Mutation_p.R1057P	NM_182920.1	NP_891550.1	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 9	1085	TSP type-1 5.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(17)|liver(4)|lung(43)|ovary(3)|prostate(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	100		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		ATCATTTAATCGATCTTCACC	0.517000													14	64					0	0	1	0	0
IGKV2D-24	28885	broad.mit.edu	37	2	90044393	90044393	+	RNA	SNP	C	C	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr2:90044393C>A	ENST00000462693.1	+	0	344																											AGGGTGGAAGCTGAGGATGTC	0.512000													82	46					1.01459e-35	1.1148e-35	1	1	0
ARHGAP26	23092	broad.mit.edu	37	5	142500673	142500673	+	Silent	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr5:142500673G>A	ENST00000378004.3	+	18	2014	c.1659G>A	c.(1657-1659)caG>caA	p.Q553Q	ARHGAP26_ENST00000274498.4_Silent_p.Q553Q	NM_001135608.1	NP_001129080.1	Q9UNA1	RHG26_HUMAN	Rho GTPase activating protein 26	553	Rho-GAP.				actin cytoskeleton organization|filopodium assembly|nervous system development|small GTPase mediated signal transduction	cytoskeleton|cytosol|focal adhesion	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(7)|ovary(1)	25		all_hematologic(541;0.0416)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TCAAATTTCAGAACATTGTCA	0.433000													20	51					0	0	1	0	0
PDE2A	5138	broad.mit.edu	37	11	72293530	72293530	+	Silent	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr11:72293530G>A	ENST00000334456.5	-	21	2054	c.1809C>T	c.(1807-1809)ttC>ttT	p.F603F	PDE2A_ENST00000376450.3_Silent_p.F347F|PDE2A_ENST00000418754.2_Silent_p.F488F|PDE2A_ENST00000540345.1_Silent_p.F594F|PDE2A_ENST00000444035.2_Silent_p.F594F|PDE2A_ENST00000544570.1_Silent_p.F596F	NM_002599.4	NP_002590.1	O00408	PDE2A_HUMAN	phosphodiesterase 2A, cGMP-stimulated	603					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity|metal ion binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(2)|lung(21)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	36			BRCA - Breast invasive adenocarcinoma(5;3.55e-05)		Sildenafil(DB00203)|Sulindac(DB00605)	GGGTATAGGTGAAACTTGCAA	0.532000													25	23					0	0	1	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140718832	140718832	+	Silent	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr5:140718832G>A	ENST00000394576.2	+	1	294	c.294G>A	c.(292-294)caG>caA	p.Q98Q	PCDHGA1_ENST00000517417.1_Intron	NM_018915.2	NP_061738.1														breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(32)|ovary(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCTGCGCTCAGAGCGCACCCT	0.498000													15	68					0	0	1	0	0
TEX2	55852	broad.mit.edu	37	17	62290103	62290103	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr17:62290103G>C	ENST00000258991.3	-	2	1559	c.1475C>G	c.(1474-1476)cCc>cGc	p.P492R	TEX2_ENST00000583097.1_Missense_Mutation_p.P492R|TEX2_ENST00000584379.1_Missense_Mutation_p.P492R			Q8IWB9	TEX2_HUMAN	testis expressed 2	492					signal transduction|sphingolipid metabolic process	integral to membrane				breast(3)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(15)|ovary(1)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(8;1.33e-10)	READ - Rectum adenocarcinoma(1115;0.0689)		CACATAGTGGGGGAGGGGGAG	0.498000													31	45					0	0	1	0	0
PHKA1	5255	broad.mit.edu	37	X	71843001	71843001	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chrX:71843001C>A	ENST00000373545.3	-	18	2356	c.1918G>T	c.(1918-1920)Gaa>Taa	p.E640*	PHKA1_ENST00000541944.1_Nonsense_Mutation_p.E640*|PHKA1_ENST00000373539.3_Nonsense_Mutation_p.E640*|PHKA1_ENST00000339490.3_Nonsense_Mutation_p.E640*|PHKA1_ENST00000373542.4_Nonsense_Mutation_p.E640*			P46020	KPB1_HUMAN	phosphorylase kinase, alpha 1 (muscle)	640					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(2)|lung(18)|ovary(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	52	Renal(35;0.156)					TTGCCAGATTCCAGGTAATCA	0.418000													31	3					5.09552e-08	5.31966e-08	1	1	0
IL10RA	3587	broad.mit.edu	37	11	117864018	117864018	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr11:117864018C>T	ENST00000227752.3	+	4	550	c.430C>T	c.(430-432)Cag>Tag	p.Q144*	IL10RA_ENST00000545409.1_5'UTR|IL10RA_ENST00000541785.1_Nonsense_Mutation_p.Q124*|IL10RA_ENST00000533700.1_3'UTR	NM_001558.3	NP_001549.2	Q13651	I10R1_HUMAN	interleukin 10 receptor, alpha	144						integral to membrane|plasma membrane	interleukin-10 receptor activity			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(10)|ovary(2)|prostate(1)	19	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.07e-05)|Epithelial(105;0.00108)		CGGGAAGATTCAGCTACCCAG	0.512000													24	43					0	0	1	0	0
KDM2B	84678	broad.mit.edu	37	12	121880471	121880471	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr12:121880471C>T	ENST00000377069.4	-	18	2972	c.2566G>A	c.(2566-2568)Gag>Aag	p.E856K	KDM2B_ENST00000377071.4_Missense_Mutation_p.E925K|KDM2B_ENST00000536437.1_Intron|KDM2B_ENST00000542973.1_Missense_Mutation_p.E293K	NM_001005366.1	NP_001005366.1	Q8NHM5	KDM2B_HUMAN	lysine (K)-specific demethylase 2B	925					embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	19						TCCGGGCCCTCGGCCCCTTCG	0.677000													12	11					0	0	1	0	0
SETD5	55209	broad.mit.edu	37	3	9514978	9514978	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr3:9514978G>A	ENST00000402466.1	+	21	3728	c.2960G>A	c.(2959-2961)gGg>gAg	p.G987E	SETD5_ENST00000402198.1_Missense_Mutation_p.G1085E|SETD5_ENST00000302463.6_Missense_Mutation_p.G987E|SETD5_ENST00000406341.1_Missense_Mutation_p.G1085E|SETD5_ENST00000407969.1_Missense_Mutation_p.G1104E			Q9C0A6	SETD5_HUMAN	SET domain containing 5	1085										NS(2)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(11)|ovary(3)|prostate(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.112)		TCTGCTGGTGGGGGAGGTGAC	0.498000													26	39					0	0	1	0	0
NEDD1	121441	broad.mit.edu	37	12	97334267	97334267	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr12:97334267G>A	ENST00000266742.4	+	10	1537	c.1198G>A	c.(1198-1200)Gat>Aat	p.D400N	NEDD1_ENST00000411739.2_Missense_Mutation_p.D311N|NEDD1_ENST00000557644.1_Missense_Mutation_p.D407N|NEDD1_ENST00000429527.2_Missense_Mutation_p.D400N|NEDD1_ENST00000457368.2_Missense_Mutation_p.D311N	NM_152905.3	NP_690869.1	Q8NHV4	NEDD1_HUMAN	neural precursor cell expressed, developmentally down-regulated 1	400					cell division|G2/M transition of mitotic cell cycle|mitosis	cytosol				breast(2)|endometrium(1)|kidney(2)|large_intestine(9)|lung(8)	22						CAGCTTTGATGATACTGGGAA	0.363000													24	39					0	0	1	0	0
ITGAV	3685	broad.mit.edu	37	2	187540556	187540556	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr2:187540556C>T	ENST00000261023.3	+	28	3104	c.2830C>T	c.(2830-2832)Cag>Tag	p.Q944*	ITGAV_ENST00000433736.2_Nonsense_Mutation_p.Q898*|AC017101.10_ENST00000453665.1_RNA|ITGAV_ENST00000374907.3_Nonsense_Mutation_p.Q908*	NM_002210.3	NP_002201	P06756	ITAV_HUMAN	integrin, alpha V	944					angiogenesis|axon guidance|blood coagulation|cell-matrix adhesion|entry of bacterium into host cell|entry of symbiont into host cell by promotion of host phagocytosis|entry of virus into host cell|ERK1 and ERK2 cascade|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|positive regulation of cell adhesion|positive regulation of cell proliferation|regulation of apoptotic cell clearance	integrin complex	receptor activity|transforming growth factor beta binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47			OV - Ovarian serous cystadenocarcinoma(117;0.0185)|Epithelial(96;0.072)|all cancers(119;0.189)	STAD - Stomach adenocarcinoma(3;0.106)|COAD - Colon adenocarcinoma(31;0.108)		GAAAGAAAATCAGAATCATTC	0.343000													6	23					0	0	1	0	0
SLC6A4	6532	broad.mit.edu	37	17	28545313	28545313	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr17:28545313G>A	ENST00000401766.2	-	4	1033	c.521C>T	c.(520-522)tCc>tTc	p.S174F	SLC6A4_ENST00000261707.3_Missense_Mutation_p.S174F			P31645	SC6A4_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 4	174					response to toxin|serotonin uptake|thalamus development	cytosol|endomembrane system|endosome membrane|membrane raft	actin filament binding|Rab GTPase binding|serotonin transmembrane transporter activity|serotonin:sodium symporter activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(4)	25					Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Citalopram(DB00215)|Clomipramine(DB01242)|Cocaine(DB00907)|Desipramine(DB01151)|Dexfenfluramine(DB01191)|Dextromethorphan(DB00514)|Doxepin(DB01142)|Duloxetine(DB00476)|Escitalopram(DB01175)|Fluoxetine(DB00472)|Fluvoxamine(DB00176)|Imipramine(DB00458)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Minaprine(DB00805)|Nefazodone(DB01149)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phentermine(DB00191)|Protriptyline(DB00344)|Sertraline(DB01104)|Sibutramine(DB01105)|Tegaserod(DB01079)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)|Zimelidine(DB04832)	GTTGTAGTAGGAAGCAATGTA	0.547000													11	19					0	0	1	0	0
CDKN2A	1029	broad.mit.edu	37	9	21971036	21971036	+	Missense_Mutation	SNP	C	C	T	rs121913381		TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr9:21971036C>T	ENST00000579755.1	-	2	657	c.365G>A	c.(364-366)cGa>cAa	p.R122Q	CDKN2A_ENST00000579122.1_Missense_Mutation_p.D108N|CDKN2A_ENST00000498124.1_Missense_Mutation_p.D108N|CDKN2A_ENST00000304494.5_Missense_Mutation_p.D108N|CDKN2A_ENST00000494262.1_Missense_Mutation_p.D57N|CDKN2A_ENST00000361570.3_Missense_Mutation_p.R163Q|RP11-145E5.5_ENST00000404796.2_Intron|CDKN2A_ENST00000479692.2_Missense_Mutation_p.D57N|CDKN2A_ENST00000578845.2_Missense_Mutation_p.D57N|CDKN2A_ENST00000497750.1_Missense_Mutation_p.D57N|CDKN2A_ENST00000530628.2_Missense_Mutation_p.R122Q|CDKN2A_ENST00000498628.2_Missense_Mutation_p.D57N|CDKN2A_ENST00000446177.1_Missense_Mutation_p.D108N			P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A	138			G -> R (in CMM2).|G -> S (in a biliary tract tumor).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein kinase binding	p.0?(1315)|p.?(44)|p.D108Y(18)|p.D108N(7)|p.D108H(7)|p.R163L(3)|p.H83fs*2(2)|p.D105fs*8(1)|p.0(1)|p.R163Q(1)|p.A68fs*3(1)|p.R107fs*33(1)		NS(28)|adrenal_gland(6)|autonomic_ganglia(11)|biliary_tract(74)|bone(84)|breast(46)|central_nervous_system(522)|cervix(23)|endometrium(14)|eye(4)|genital_tract(15)|haematopoietic_and_lymphoid_tissue(698)|kidney(39)|large_intestine(11)|liver(92)|lung(365)|meninges(18)|oesophagus(239)|ovary(98)|pancreas(263)|pleura(94)|prostate(13)|salivary_gland(10)|skin(541)|small_intestine(1)|soft_tissue(93)|stomach(48)|thymus(4)|thyroid(24)|upper_aerodigestive_tract(436)|urinary_tract(283)|vulva(2)	4199		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		CCCCAGGCATCGCGCACGTCC	0.741000		17								HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			10	16					0	0	1	0	0
DAZAP1	26528	broad.mit.edu	37	19	1434778	1434778	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr19:1434778C>G	ENST00000233078.4	+	12	1252	c.1091C>G	c.(1090-1092)tCa>tGa	p.S364*	DAZAP1_ENST00000336761.6_3'UTR	NM_018959.2	NP_061832.2	Q96EP5	DAZP1_HUMAN	DAZ associated protein 1	364	Pro-rich.				cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleotide binding|RNA binding			breast(2)|endometrium(2)|large_intestine(1)|lung(3)|upper_aerodigestive_tract(1)	9		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGGGCTTCTCAGACCCCAGC	0.706000													31	4					0	0	1	0	0
GRIA1	2890	broad.mit.edu	37	5	153054212	153054212	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr5:153054212G>C	ENST00000285900.5	+	6	1195	c.852G>C	c.(850-852)aaG>aaC	p.K284N	GRIA1_ENST00000448073.4_Missense_Mutation_p.K294N|GRIA1_ENST00000521843.2_Missense_Mutation_p.K215N|GRIA1_ENST00000518142.1_Missense_Mutation_p.K204N|GRIA1_ENST00000518783.1_Missense_Mutation_p.K294N|GRIA1_ENST00000340592.5_Missense_Mutation_p.K284N	NM_000827.3|NM_001258019.1	NP_000818.2|NP_001244948.1	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1	284					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			NS(1)|breast(4)|endometrium(7)|kidney(3)|large_intestine(24)|liver(2)|lung(23)|ovary(4)|pancreas(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	81		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	TGGACTGGAAGAGACCCAAGG	0.537000													10	23					0	0	1	0	0
CNGB1	1258	broad.mit.edu	37	16	57931375	57931375	+	Silent	SNP	G	G	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr16:57931375G>T	ENST00000564448.1	-	31	3210	c.3150C>A	c.(3148-3150)atC>atA	p.I1050I	CNGB1_ENST00000251102.8_Silent_p.I1056I			Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1	1056					sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(7)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(11)|liver(1)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	54						TCTTATCCAGGATGAAGAGGT	0.527000													18	24					3.32936e-07	3.4455e-07	1	1	0
SVEP1	79987	broad.mit.edu	37	9	113166794	113166794	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr9:113166794G>T	ENST00000401783.2	-	39	9815	c.9479C>A	c.(9478-9480)aCa>aAa	p.T3160K	SVEP1_ENST00000297826.5_Missense_Mutation_p.T1086K|SVEP1_ENST00000374469.1_Missense_Mutation_p.T3137K	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	3160	Sushi 29.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						ACAGGTGAATGTATCTGTATC	0.393000													79	138					4.34595e-34	4.76049e-34	1	1	0
ABCC4	10257	broad.mit.edu	37	13	95727734	95727734	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr13:95727734C>T	ENST00000376887.4	-	22	2872	c.2758G>A	c.(2758-2760)Gaa>Aaa	p.E920K	ABCC4_ENST00000412704.1_Missense_Mutation_p.E873K	NM_005845.3	NP_005836.2	O15439	MRP4_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	920	ABC transmembrane type-1 2.				platelet activation|platelet degranulation	integral to membrane|membrane fraction|plasma membrane|platelet dense granule membrane	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|chloride channel activity			breast(1)|central_nervous_system(4)|endometrium(5)|kidney(4)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	43	all_neural(89;0.0878)|Medulloblastoma(90;0.163)				Cefazolin(DB01327)	CACCTCTCTTCTGCTTTGTAT	0.473000													26	63					0	0	1	0	0
STAG1	10274	broad.mit.edu	37	3	136078117	136078117	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr3:136078117C>G	ENST00000383202.2	-	27	3065	c.2809G>C	c.(2809-2811)Gag>Cag	p.E937Q	STAG1_ENST00000236698.5_Missense_Mutation_p.E937Q|STAG1_ENST00000434713.2_Missense_Mutation_p.E677Q|STAG1_ENST00000536929.1_Missense_Mutation_p.E521Q	NM_005862.2	NP_005853.2	Q8WVM7	STAG1_HUMAN	stromal antigen 1	937					cell division|chromosome segregation|mitotic metaphase/anaphase transition|mitotic prometaphase	cell junction|chromatin|chromosome, centromeric region|nucleoplasm	protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(16)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58						GGACCTTGCTCTTGAACAAGT	0.353000													20	22					0	0	1	0	0
PCDHB12	56124	broad.mit.edu	37	5	140590502	140590502	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr5:140590502G>T	ENST00000239450.2	+	1	2212	c.2023G>T	c.(2023-2025)Gag>Tag	p.E675*	PCDHB12_ENST00000541609.1_Nonsense_Mutation_p.E338*	NM_018932.3	NP_061755.1	Q9Y5F1	PCDBC_HUMAN		675					homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(10)|large_intestine(17)|lung(38)|ovary(3)|pancreas(1)|prostate(2)|skin(7)|stomach(1)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCCTCTCCCGGAGGCGGCCCC	0.687000													71	41					4.81439e-37	5.30627e-37	1	1	0
ADD3	120	broad.mit.edu	37	10	111878402	111878402	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr10:111878402G>A	ENST00000277900.8	+	6	990	c.625G>A	c.(625-627)Gac>Aac	p.D209N	ADD3_ENST00000360162.3_Missense_Mutation_p.D209N|ADD3_ENST00000356080.4_Missense_Mutation_p.D209N	NM_001121.2	NP_001112.2	Q9UEY8	ADDG_HUMAN	adducin 3 (gamma)	209						cytoskeleton	actin binding|calmodulin binding|metal ion binding|structural constituent of cytoskeleton			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	29		Breast(234;0.052)|Lung NSC(174;0.223)		Epithelial(162;4.15e-05)|all cancers(201;0.000587)|BRCA - Breast invasive adenocarcinoma(275;0.0742)		TTTGAAAATTGACCATACAGG	0.393000													40	31					0	0	1	0	0
RHOBTB1	9886	broad.mit.edu	37	10	62634778	62634778	+	Silent	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr10:62634778C>T	ENST00000337910.5	-	9	2086	c.1749G>A	c.(1747-1749)ttG>ttA	p.L583L	RHOBTB1_ENST00000357917.4_Silent_p.L583L|RHOBTB1_ENST00000490827.1_5'UTR	NM_001242359.1|NM_014836.4	NP_001229288.1|NP_055651.1	O94844	RHBT1_HUMAN	Rho-related BTB domain containing 1	583					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			endometrium(4)|large_intestine(6)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	23	Prostate(12;0.0112)					CGGCTTTGGTCAACTCCTGAA	0.532000													11	34					0	0	1	0	0
LYL1	4066	broad.mit.edu	37	19	13211529	13211529	+	Silent	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr19:13211529G>A	ENST00000264824.4	-	3	729	c.369C>T	c.(367-369)atC>atT	p.I123I		NM_005583.4	NP_005574.2	P12980	LYL1_HUMAN	lymphoblastic leukemia derived sequence 1	123					B cell differentiation|blood vessel maturation|definitive hemopoiesis|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			cervix(1)|endometrium(2)|kidney(1)|lung(2)|prostate(1)	7			OV - Ovarian serous cystadenocarcinoma(19;6.08e-22)			TGCTAGGGAAGATGCTAAAAG	0.582000			T	TRB@	T-ALL								22	72					0	0	1	0	0
GLYR1	84656	broad.mit.edu	37	16	4871444	4871444	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr16:4871444G>A	ENST00000321919.9	-	9	819	c.743C>T	c.(742-744)tCc>tTc	p.S248F	GLYR1_ENST00000436648.5_Missense_Mutation_p.S167F|GLYR1_ENST00000381983.3_Missense_Mutation_p.S231F|GLYR1_ENST00000591451.1_Missense_Mutation_p.S248F	NM_032569.3	NP_115958	Q49A26	GLYR1_HUMAN	glyoxylate reductase 1 homolog (Arabidopsis)	248					pentose-phosphate shunt	nucleus	coenzyme binding|DNA binding|methylated histone residue binding|phosphogluconate dehydrogenase (decarboxylating) activity			endometrium(1)|kidney(1)|large_intestine(7)|lung(6)|prostate(2)|skin(1)|urinary_tract(1)	19						GATGGAGGTGGAGCCAGTTTC	0.527000													17	33					0	0	1	0	0
SCUBE3	222663	broad.mit.edu	37	6	35199542	35199542	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr6:35199542G>C	ENST00000274938.7	+	4	375	c.375G>C	c.(373-375)caG>caC	p.Q125H	SCUBE3_ENST00000394681.1_Missense_Mutation_p.Q125H	NM_152753.2	NP_689966.2	Q8IX30	SCUB3_HUMAN	signal peptide, CUB domain, EGF-like 3	125	EGF-like 3; calcium-binding (Potential).				protein heterooligomerization|protein homooligomerization	cell surface|extracellular region	calcium ion binding|protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(12)|lung(11)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	37						GCTGTCAGCAGAGCTGTGTCA	0.592000													14	23					0	0	1	0	0
STAC3	246329	broad.mit.edu	37	12	57642566	57642566	+	Missense_Mutation	SNP	G	G	A	rs146313451		TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr12:57642566G>A	ENST00000332782.2	-	4	556	c.355C>T	c.(355-357)Cgc>Tgc	p.R119C	STAC3_ENST00000554578.1_Missense_Mutation_p.R80C|STAC3_ENST00000546246.2_Intron	NM_145064.1	NP_659501.1	Q96MF2	STAC3_HUMAN	SH3 and cysteine rich domain 3	119					intracellular signal transduction		identical protein binding|metal ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(10)|ovary(2)|skin(1)	18						TTCTTACAGCGAAGCCCAAAC	0.468000													86	148					0	0	1	0	0
DNAJA4	55466	broad.mit.edu	37	15	78572689	78572689	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr15:78572689C>G	ENST00000394855.3	+	8	1396	c.1168C>G	c.(1168-1170)Cag>Gag	p.Q390E	DNAJA4_ENST00000394852.3_Missense_Mutation_p.Q361E|DNAJA4_ENST00000446172.2_Missense_Mutation_p.Q334E|DNAJA4_ENST00000343789.3_Missense_Mutation_p.Q361E	NM_018602.3	NP_061072.3	Q8WW22	DNJA4_HUMAN	DnaJ (Hsp40) homolog, subfamily A, member 4	361					protein folding|response to heat	membrane	ATP binding|heat shock protein binding|metal ion binding|unfolded protein binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)|skin(1)	8						TGACATGGATCAGGTGGAGCT	0.527000													35	3					0	0	1	0	0
SLC45A1	50651	broad.mit.edu	37	1	8384632	8384632	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr1:8384632G>C	ENST00000471889.1	+	2	628	c.243G>C	c.(241-243)caG>caC	p.Q81H	SLC45A1_ENST00000377479.2_Missense_Mutation_p.Q115H|SLC45A1_ENST00000289877.8_Missense_Mutation_p.Q81H			Q9Y2W3	S45A1_HUMAN	solute carrier family 45, member 1	81					carbohydrate transport	integral to membrane	symporter activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|liver(1)|lung(12)|ovary(2)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(2)	33	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;1.22e-15)|all_lung(118;0.000147)|Lung NSC(185;0.000251)|Renal(390;0.000469)|Colorectal(325;0.00578)|Breast(348;0.00686)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;3.95e-66)|GBM - Glioblastoma multiforme(8;5.93e-33)|Colorectal(212;2.86e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		TGCACCCCCAGAGGTCCTTCC	0.642000													5	12					0	0	1	0	0
NFXL1	152518	broad.mit.edu	37	4	47887618	47887618	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr4:47887618G>C	ENST00000507489.1	-	14	1897	c.1721C>G	c.(1720-1722)tCt>tGt	p.S574C	NFXL1_ENST00000329043.3_Missense_Mutation_p.S574C|NFXL1_ENST00000381538.3_Missense_Mutation_p.S574C	NM_001278624.1	NP_001265553.1	Q6ZNB6	NFXL1_HUMAN	nuclear transcription factor, X-box binding-like 1	574						integral to membrane|nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|skin(4)	27						TGGTGGACAAGAACCAAAGTG	0.383000													15	48					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578513	7578513	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr17:7578513C>G	ENST00000420246.2	-	5	549	c.417G>C	c.(415-417)aaG>aaC	p.K139N	TP53_ENST00000455263.2_Missense_Mutation_p.K139N|TP53_ENST00000359597.4_Missense_Mutation_p.K139N|TP53_ENST00000413465.2_Missense_Mutation_p.K139N|TP53_ENST00000445888.2_Missense_Mutation_p.K139N|TP53_ENST00000269305.4_Missense_Mutation_p.K139N	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	139	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		K -> E (in sporadic cancers; somatic mutation).|K -> N (in sporadic cancers; somatic mutation).|K -> Q (in sporadic cancers; somatic mutation).|K -> R (in sporadic cancers; somatic mutation).|K -> T (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.K139N(9)|p.0?(8)|p.K139K(7)|p.A138_P142delAKTCP(4)|p.C135fs*9(3)|p.K139_T140delKT(3)|p.N131fs*27(2)|p.L137_W146del10(1)|p.K139fs*9(1)|p.K46_T47delKT(1)|p.F134_T140>S(1)|p.A45_P49delAKTCP(1)|p.K7_T8delKT(1)|p.C3fs*9(1)|p.A6_P10delAKTCP(1)|p.A138_V143delAKTCPV(1)|p.K139fs*10(1)|p.K139fs*4(1)|p.C42fs*9(1)|p.Q136_K139delQLAK(1)|p.K139_C141>N(1)|p.C135_T140delCQLAKT(1)|p.K139fs*29(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CAGGGCAGGTCTTGGCCAGTT	0.567000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			18	4					0	0	1	0	0
CEP350	9857	broad.mit.edu	37	1	179985015	179985015	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr1:179985015C>G	ENST00000367607.3	+	11	2502	c.2084C>G	c.(2083-2085)tCt>tGt	p.S695C		NM_014810.4	NP_055625.4	Q5VT06	CE350_HUMAN	centrosomal protein 350kDa	695						centrosome|nucleus|spindle				central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	66						TCTGGAGAATCTGACAAAGAA	0.433000													13	17					0	0	1	0	0
LMAN1	3998	broad.mit.edu	37	18	57000376	57000376	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr18:57000376C>G	ENST00000251047.5	-	11	2038	c.1321G>C	c.(1321-1323)Gag>Cag	p.E441Q		NM_005570.3	NP_005561.1	P49257	LMAN1_HUMAN	lectin, mannose-binding, 1	441					blood coagulation|ER to Golgi vesicle-mediated transport|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|protein transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane	mannose binding|metal ion binding|unfolded protein binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	16		Colorectal(73;0.0946)			Antihemophilic Factor(DB00025)	TGCAGGTGCTCTTTGATGTCA	0.418000													35	30					0	0	1	0	0
KLHL35	283212	broad.mit.edu	37	11	75133737	75133737	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr11:75133737C>G	ENST00000539798.1	-	6	1638	c.1639G>C	c.(1639-1641)Gat>Cat	p.D547H	KLHL35_ENST00000376292.4_Missense_Mutation_p.D327H	NM_001039548.2	NP_001034637.2	Q6PF15	KLH35_HUMAN	kelch-like family member 35	327										lung(2)|stomach(1)	3						AAGACCTTATCGGTGCTTTCT	0.592000													19	45					0	0	1	0	0
CLCN2	1181	broad.mit.edu	37	3	184064408	184064408	+	Missense_Mutation	SNP	C	C	T	rs150751460	byFrequency	TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr3:184064408C>T	ENST00000265593.4	-	24	2854	c.2683G>A	c.(2683-2685)Gac>Aac	p.D895N	CLCN2_ENST00000344937.7_Missense_Mutation_p.D878N|CLCN2_ENST00000423355.2_3'UTR|EIF2B5_ENST00000444495.1_Intron|CLCN2_ENST00000457512.1_Missense_Mutation_p.D866N|CLCN2_ENST00000434054.2_Missense_Mutation_p.D851N	NM_004366.5	NP_004357.3	P51788	CLCN2_HUMAN	chloride channel, voltage-sensitive 2	895						chloride channel complex	voltage-gated chloride channel activity			breast(2)|central_nervous_system(4)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	27	all_cancers(143;6.66e-11)|Ovarian(172;0.0339)		Epithelial(37;2.22e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Lubiprostone(DB01046)	TGGCATTTGTCGTCGCTGTCG	0.627000													10	32					0	0	1	0	0
PRMT8	56341	broad.mit.edu	37	12	3649871	3649871	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr12:3649871G>A	ENST00000382622.3	+	2	565	c.175G>A	c.(175-177)Ggc>Agc	p.G59S	PRMT8_ENST00000261252.4_3'UTR|PRMT8_ENST00000452611.2_Missense_Mutation_p.G50S	NM_019854.4	NP_062828.3	Q9NR22	ANM8_HUMAN	protein arginine methyltransferase 8	59					regulation of protein binding	cytoplasm|plasma membrane	histone-arginine N-methyltransferase activity|protein heterodimerization activity|protein homodimerization activity|protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(9)|lung(14)|ovary(3)|skin(5)|upper_aerodigestive_tract(1)	37			OV - Ovarian serous cystadenocarcinoma(31;0.0109)|COAD - Colon adenocarcinoma(12;0.0264)			CCCAGGACGGGGCAAGATGTC	0.597000													29	141					0	0	1	0	0
IDH3B	3420	broad.mit.edu	37	20	2639120	2639120	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr20:2639120C>T	ENST00000380851.5	-	12	1150	c.1120G>A	c.(1120-1122)Gag>Aag	p.E374K	IDH3B_ENST00000380843.4_3'UTR|IDH3B_ENST00000488299.1_5'UTR	NM_001258384.1|NM_174855.2	NP_001245313.1|NP_777280.1	O43837	IDH3B_HUMAN	isocitrate dehydrogenase 3 (NAD+) beta	374					isocitrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix	electron carrier activity|isocitrate dehydrogenase (NAD+) activity|magnesium ion binding|NAD binding			breast(1)|endometrium(3)|kidney(2)|lung(7)|prostate(1)	14					NADH(DB00157)	ATGACAGCCTCAGTGAAGTCA	0.478000													11	12					0	0	1	0	0
MYO1A	4640	broad.mit.edu	37	12	57423252	57423252	+	Silent	SNP	G	G	C			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr12:57423252G>C	ENST00000442789.2	-	27	3131	c.2844C>G	c.(2842-2844)ctC>ctG	p.L948L	MYO1A_ENST00000300119.3_Silent_p.L948L|MYO1A_ENST00000544473.1_Silent_p.L786L	NM_001256041.1	NP_001242970.1	Q9UBC5	MYO1A_HUMAN	myosin IA	948					sensory perception of sound|vesicle localization	brush border|cortical actin cytoskeleton|filamentous actin|lateral plasma membrane|microvillus|myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(17)|ovary(2)|skin(7)|urinary_tract(3)	50						GCCCATCCTTGAGGCTGGTGA	0.557000													49	70					0	0	1	0	0
GRAMD4	23151	broad.mit.edu	37	22	47062746	47062746	+	Silent	SNP	C	C	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr22:47062746C>A	ENST00000406902.1	+	10	1047	c.834C>A	c.(832-834)atC>atA	p.I278I	GRAMD4_ENST00000361034.3_Silent_p.I278I			Q6IC98	GRAM4_HUMAN	GRAM domain containing 4	278					apoptosis	integral to membrane|mitochondrial membrane				breast(1)|endometrium(1)|large_intestine(1)|lung(7)|ovary(1)|skin(1)	12		Breast(42;0.00571)|Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|BRCA - Breast invasive adenocarcinoma(115;0.166)		AGTGGAGCATCGTGCCCGAAG	0.617000													23	30					2.41591e-17	2.59056e-17	1	1	0
CASP1	834	broad.mit.edu	37	11	104901142	104901142	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr11:104901142C>T	ENST00000533400.1	-	5	577	c.542G>A	c.(541-543)gGa>gAa	p.G181E	CASP1_ENST00000531166.1_Intron|CASP1_ENST00000436863.3_Missense_Mutation_p.G181E|CASP1_ENST00000594519.1_Missense_Mutation_p.G88E|CASP1_ENST00000598974.1_Missense_Mutation_p.G181E|CASP1_ENST00000446369.1_Missense_Mutation_p.G88E|CASP1_ENST00000415981.2_Intron|CASP1_ENST00000393136.4_Missense_Mutation_p.G160E|CASP1_ENST00000353247.5_Intron|CASP1_ENST00000534497.1_Missense_Mutation_p.G88E|CASP1_ENST00000527979.1_Missense_Mutation_p.G144E|CASP1_ENST00000526568.1_Missense_Mutation_p.G88E|CASP1_ENST00000525825.1_Missense_Mutation_p.G160E|CASP1_ENST00000528974.1_Missense_Mutation_p.G142E|CASP1_ENST00000593315.1_Missense_Mutation_p.G160E	NM_001257118.1	NP_001244047.1	P29466	CASP1_HUMAN	caspase 1, apoptosis-related cysteine peptidase	181					cellular response to mechanical stimulus|cellular response to organic substance|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis|signal transduction	cytosol	caspase activator activity|cysteine-type endopeptidase activity|protein binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|ovary(2)	5		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000525)|Epithelial(105;0.0128)|all cancers(92;0.0482)	Minocycline(DB01017)|Penicillamine(DB00859)	AACCTCAGCTCCAGTTCTTCT	0.403000													52	29					0	0	1	0	0
EHMT1	79813	broad.mit.edu	37	9	140652431	140652431	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr9:140652431G>A	ENST00000460843.1	+	9	1496	c.1469G>A	c.(1468-1470)cGa>cAa	p.R490Q	EHMT1_ENST00000462484.1_Missense_Mutation_p.R490Q|EHMT1_ENST00000334856.6_Missense_Mutation_p.R459Q|EHMT1_ENST00000371394.2_3'UTR	NM_024757.4	NP_079033.4	Q9H9B1	EHMT1_HUMAN	euchromatic histone-lysine N-methyltransferase 1	490					DNA methylation|embryo development|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(16)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	41	all_cancers(76;0.164)			OV - Ovarian serous cystadenocarcinoma(145;0.000183)|Epithelial(140;0.000728)		CTGGATCTCCGAGTCAAAGGA	0.522000													64	44					0	0	1	0	0
SETX	23064	broad.mit.edu	37	9	135153600	135153600	+	Silent	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr9:135153600G>A	ENST00000372169.2	-	21	6881	c.6699C>T	c.(6697-6699)ttC>ttT	p.F2233F	SETX_ENST00000393220.1_Silent_p.F2233F|SETX_ENST00000224140.5_Silent_p.F2233F			Q7Z333	SETX_HUMAN	senataxin	2233					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(1)|lung(36)|ovary(2)|prostate(2)|skin(1)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	97		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		GCAGTCTGCAGAAGCGAGCCA	0.458000													36	87					0	0	1	0	0
PTH2R	5746	broad.mit.edu	37	2	209309531	209309531	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr2:209309531G>C	ENST00000272847.2	+	7	985	c.772G>C	c.(772-774)Ggt>Cgt	p.G258R	PTH2R_ENST00000413482.1_3'UTR	NM_005048.2	NP_005039.1	P49190	PTH2R_HUMAN	parathyroid hormone 2 receptor	258						integral to plasma membrane	parathyroid hormone receptor activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(21)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	43				Epithelial(149;0.0684)|Lung(261;0.0785)|LUSC - Lung squamous cell carcinoma(261;0.0836)		CCTGGTGGAAGGTCTCTACCT	0.393000													5	133					0	0	1	0	0
ACVR1	90	broad.mit.edu	37	2	158622616	158622616	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr2:158622616G>T	ENST00000263640.3	-	8	1312	c.883C>A	c.(883-885)Ctt>Att	p.L295I	ACVR1_ENST00000410057.2_Missense_Mutation_p.L295I|ACVR1_ENST00000434821.1_Missense_Mutation_p.L295I|ACVR1_ENST00000409283.2_Missense_Mutation_p.L295I	NM_001105.4	NP_001096.1	Q04771	ACVR1_HUMAN	activin A receptor, type I	295	Protein kinase.				BMP signaling pathway|G1/S transition of mitotic cell cycle|negative regulation of activin receptor signaling pathway|negative regulation of apoptosis|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	activin receptor complex	activin binding|ATP binding|follistatin binding|metal ion binding|protein homodimerization activity|SMAD binding|transforming growth factor beta binding			endometrium(4)|kidney(1)|large_intestine(4)|lung(6)|ovary(2)|skin(2)	19				BRCA - Breast invasive adenocarcinoma(221;0.104)	Adenosine triphosphate(DB00171)	GTAAGCTGAAGATAGTCGTAC	0.438000													22	23					1.10923e-09	1.17177e-09	1	1	0
SLC9A7P1	121456	broad.mit.edu	37	12	98849649	98849649	+	RNA	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr12:98849649G>A	ENST00000554295.1	-	0	1274					NR_033801.1																						AGGAGAAGATGAAGTTCTCTG	0.468000													40	40					0	0	1	0	0
LILRA2	11027	broad.mit.edu	37	19	55087518	55087518	+	Silent	SNP	C	C	G			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr19:55087518C>G	ENST00000251377.3	+	7	1330	c.1197C>G	c.(1195-1197)ctC>ctG	p.L399L	LILRA2_ENST00000391737.1_Silent_p.L387L|LILRA2_ENST00000251376.3_Silent_p.L399L|LILRB1_ENST00000418536.2_Intron|LILRA2_ENST00000391738.3_Silent_p.L399L|LILRB1_ENST00000396321.2_Intron|LILRB1_ENST00000448689.1_Intron					leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2											breast(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(33)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	50				GBM - Glioblastoma multiforme(193;0.0963)		ACAGCTCACTCAGCTCCAACC	0.592000													38	51					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103130252	103130252	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr7:103130252G>C	ENST00000428762.1	-	60	9859	c.9700C>G	c.(9700-9702)Ctc>Gtc	p.L3234V	RELN_ENST00000343529.5_Missense_Mutation_p.L3234V|CTB-107G13.1_ENST00000422488.1_RNA|RELN_ENST00000424685.2_Missense_Mutation_p.L3234V	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	3234	EGF-like 8.				axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CCGCTGCAGAGCTTGGGGCAA	0.547000													27	18					0	0	1	0	0
ADD3	120	broad.mit.edu	37	10	111883999	111883999	+	Silent	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr10:111883999G>A	ENST00000277900.8	+	10	1733	c.1368G>A	c.(1366-1368)cgG>cgA	p.R456R	ADD3_ENST00000360162.3_Silent_p.R456R|ADD3_ENST00000356080.4_Silent_p.R456R	NM_001121.2	NP_001112.2	Q9UEY8	ADDG_HUMAN	adducin 3 (gamma)	456						cytoskeleton	actin binding|calmodulin binding|metal ion binding|structural constituent of cytoskeleton			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	29		Breast(234;0.052)|Lung NSC(174;0.223)		Epithelial(162;4.15e-05)|all cancers(201;0.000587)|BRCA - Breast invasive adenocarcinoma(275;0.0742)		AGGAGTCTCGGAACGGAGAAA	0.413000													30	33					0	0	1	0	0
SACM1L	22908	broad.mit.edu	37	3	45785138	45785138	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr3:45785138G>T	ENST00000389061.5	+	20	1945	c.1741G>T	c.(1741-1743)Gtc>Ttc	p.V581F	SACM1L_ENST00000418611.1_Missense_Mutation_p.V478F|SACM1L_ENST00000541314.1_Missense_Mutation_p.V520F	NM_014016.3	NP_054735.3	Q9NTJ5	SAC1_HUMAN	SAC1 suppressor of actin mutations 1-like (yeast)	581						Golgi apparatus				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)	23				BRCA - Breast invasive adenocarcinoma(193;0.0102)|KIRC - Kidney renal clear cell carcinoma(197;0.0234)|Kidney(197;0.0277)		TCCCAGACTGGTCCAGAAAGA	0.428000													72	33					1.12115e-39	1.23954e-39	1	1	0
IGSF3	3321	broad.mit.edu	37	1	117158893	117158893	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr1:117158893G>C	ENST00000369486.3	-	3	995	c.230C>G	c.(229-231)tCt>tGt	p.S77C	IGSF3_ENST00000369483.1_Missense_Mutation_p.S77C|IGSF3_ENST00000318837.6_Missense_Mutation_p.S77C	NM_001007237.1	NP_001007238.1	O75054	IGSF3_HUMAN	immunoglobulin superfamily, member 3	77	Ig-like C2-type 1.					integral to membrane				NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(31)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	62	Lung SC(450;0.225)	all_cancers(81;1.24e-06)|all_epithelial(167;4.85e-07)|all_lung(203;1.66e-06)|Lung NSC(69;1.11e-05)		Lung(183;0.0142)|Colorectal(144;0.0929)|LUSC - Lung squamous cell carcinoma(189;0.108)|COAD - Colon adenocarcinoma(174;0.139)|all cancers(265;0.159)|Epithelial(280;0.166)		GGGGAAGGAAGAGTCCATGGT	0.542000													17	18					0	0	1	0	0
SYT10	341359	broad.mit.edu	37	12	33560254	33560254	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr12:33560254G>T	ENST00000228567.3	-	3	843	c.547C>A	c.(547-549)Cag>Aag	p.Q183K	SYT10_ENST00000535526.1_Missense_Mutation_p.Q2K	NM_198992.3	NP_945343.1	Q6XYQ8	SYT10_HUMAN	synaptotagmin X	183						cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|prostate(3)|skin(4)|urinary_tract(1)	42	Lung NSC(5;8.37e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0334)					CTGGAAACCTGCATTTGCCTC	0.428000													51	67					5.57489e-27	6.0693e-27	1	1	0
MCM3AP	8888	broad.mit.edu	37	21	47666262	47666262	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr21:47666262C>T	ENST00000397708.1	-	23	4860	c.4606G>A	c.(4606-4608)Gag>Aag	p.E1536K	MCM3AP_ENST00000291688.1_Missense_Mutation_p.E1536K|MCM3AP-AS1_ENST00000414659.1_RNA|MCM3AP-AS1_ENST00000590829.1_RNA|MCM3AP-AS1_ENST00000455567.1_RNA|MCM3AP_ENST00000467026.1_5'UTR			O60318	MCM3A_HUMAN	minichromosome maintenance complex component 3 associated protein	1536					DNA replication|protein import into nucleus	cytosol|nucleus	DNA binding|nucleotide binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(10)|kidney(5)|large_intestine(17)|lung(24)|ovary(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	72	Breast(49;0.112)					TCAGGGATCTCGGTAACAGTG	0.383000													21	25					0	0	1	0	0
ZBTB16	7704	broad.mit.edu	37	11	113934475	113934475	+	Silent	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr11:113934475G>A	ENST00000335953.4	+	2	833	c.453G>A	c.(451-453)cgG>cgA	p.R151R	ZBTB16_ENST00000392996.2_Silent_p.R151R	NM_006006.4	NP_005997.2	Q05516	ZBT16_HUMAN	zinc finger and BTB domain containing 16	151					apoptosis|central nervous system development|mesonephros development|myeloid cell differentiation|negative regulation of myeloid cell differentiation|negative regulation of transcription, DNA-dependent	nuclear speck|PML body|transcriptional repressor complex	protein homodimerization activity|zinc ion binding			central_nervous_system(1)|large_intestine(2)|skin(1)|upper_aerodigestive_tract(2)	6		all_cancers(61;3.79e-18)|all_epithelial(67;2.32e-10)|all_hematologic(158;2.96e-05)|Melanoma(852;0.000362)|Acute lymphoblastic leukemia(157;0.00108)|Breast(348;0.0104)|all_neural(223;0.0294)|Prostate(24;0.0318)|Medulloblastoma(222;0.0438)		BRCA - Breast invasive adenocarcinoma(274;6.75e-06)|Epithelial(105;0.000181)|all cancers(92;0.0018)		GCAAGGCTCGGTACCTCAAGA	0.612000													7	20					0	0	1	0	0
TSPEAR	54084	broad.mit.edu	37	21	45947229	45947229	+	Silent	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr21:45947229C>T	ENST00000323084.4	-	7	1160	c.1095G>A	c.(1093-1095)caG>caA	p.Q365Q	TSPEAR_ENST00000397916.1_Silent_p.Q297Q	NM_001272037.1|NM_144991.2	NP_001258966.1|NP_659428.2	Q8WU66	TSEAR_HUMAN	thrombospondin-type laminin G domain and EAR repeats	365					cell adhesion	extracellular region	structural molecule activity			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	37						TGGGGATGTTCTGATATGAGA	0.537000													41	52					0	0	1	0	0
IGHA1	3493	broad.mit.edu	37	14	106174870	106174870	+	RNA	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr14:106174870C>T	ENST00000390547.2	-	0	132																											ACGCCCTGTCCGCTTTCGCTC	0.657000													20	16					0	0	1	0	0
NPHP4	261734	broad.mit.edu	37	1	5934639	5934639	+	Silent	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr1:5934639G>A	ENST00000378156.4	-	22	3388	c.3123C>T	c.(3121-3123)ttC>ttT	p.F1041F	NPHP4_ENST00000478423.2_5'UTR	NM_015102.3	NP_055917.1	O75161	NPHP4_HUMAN	nephronophthisis 4	1041					actin cytoskeleton organization|cell-cell adhesion|signal transduction|visual behavior	cell-cell junction|centrosome|cilium|microtubule basal body	protein binding|structural molecule activity			NS(1)|breast(2)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(15)|ovary(2)|pancreas(1)|prostate(4)	47	Ovarian(185;0.0634)	all_cancers(23;7.53e-41)|all_epithelial(116;3.96e-23)|all_lung(118;5.12e-09)|all_hematologic(16;5.45e-07)|Lung NSC(185;5.49e-07)|all_neural(13;3.21e-06)|Acute lymphoblastic leukemia(12;3.44e-05)|Breast(487;0.000601)|Renal(390;0.0007)|Colorectal(325;0.00113)|Hepatocellular(190;0.00213)|Glioma(11;0.00223)|Myeloproliferative disorder(586;0.0256)|Ovarian(437;0.04)|Lung SC(97;0.128)|Medulloblastoma(700;0.213)		Epithelial(90;1.69e-36)|GBM - Glioblastoma multiforme(13;5.07e-29)|OV - Ovarian serous cystadenocarcinoma(86;1.05e-19)|Colorectal(212;4.54e-07)|COAD - Colon adenocarcinoma(227;3.14e-05)|Kidney(185;0.00012)|BRCA - Breast invasive adenocarcinoma(365;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00179)|STAD - Stomach adenocarcinoma(132;0.00472)|READ - Rectum adenocarcinoma(331;0.0649)		CACGCAGGTGGAACATGTCCT	0.662000													7	9					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152690261	152690261	+	Splice_Site	SNP	G	G	C			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr6:152690261G>C	ENST00000367255.5	-	61	10254	c.9653C>G	c.(9652-9654)tCt>tGt	p.S3218C	SYNE1_ENST00000423061.1_Splice_Site_p.S3225C|SYNE1_ENST00000341594.5_Splice_Site_p.S3257C|SYNE1_ENST00000265368.4_Splice_Site_p.S3218C|SYNE1_ENST00000448038.1_Splice_Site_p.S3225C	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	3218					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTCAAGGACAGACTGAAAAGC	0.512000										HNSCC(10;0.0054)			29	35					0	0	1	0	0
RILP	83547	broad.mit.edu	37	17	1550279	1550279	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr17:1550279C>A	ENST00000301336.6	-	7	1221	c.949G>T	c.(949-951)Gat>Tat	p.D317Y		NM_031430.2	NP_113618.2	Q96NA2	RILP_HUMAN	Rab interacting lysosomal protein	317	Necessary for the interaction with RAB7 and RAB34, lysosomal distribution and morphology.				endosome to lysosome transport|protein transport	late endosome membrane|lysosomal membrane|phagocytic vesicle membrane	Rab GTPase binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(4)	15				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		CCAGCCTCATCCTCACTGAGA	0.582000													4	13					0.000602214	0.000612538	1	1	0
FAM89B	23625	broad.mit.edu	37	11	65340946	65340946	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr11:65340946C>T	ENST00000316409.2	+	2	686	c.365C>T	c.(364-366)tCa>tTa	p.S122L	FAM89B_ENST00000449319.2_Silent_p.V138V|FAM89B_ENST00000530349.1_Missense_Mutation_p.S135L	NM_001098784.1|NM_001098785.1|NM_152832.2	NP_001092254.1|NP_001092255.1|NP_690045.1	Q8N5H3	FA89B_HUMAN	family with sequence similarity 89, member B	122										large_intestine(1)|urinary_tract(2)	3						CAGGACCTGTCATCCTCCCTC	0.612000													22	8					0	0	1	0	0
HEXIM1	10614	broad.mit.edu	37	17	43227358	43227358	+	Silent	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr17:43227358C>T	ENST00000332499.2	+	1	2675	c.801C>T	c.(799-801)ttC>ttT	p.F267F		NM_006460.2	NP_006451.1	O94992	HEXI1_HUMAN	hexamethylene bis-acetamide inducible 1	267					negative regulation of cyclin-dependent protein kinase activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	cyclin-dependent protein kinase inhibitor activity|protein binding|snRNA binding			breast(1)|kidney(2)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11						AGCGGGACTTCTCGGAGACGT	0.602000													30	21					0	0	1	0	0
EFNB3	1949	broad.mit.edu	37	17	7612893	7612893	+	Silent	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr17:7612893G>A	ENST00000226091.2	+	5	1419	c.1022G>A	c.(1021-1023)tGa>tAa	p.*341*		NM_001406.3	NP_001397.1	Q15768	EFNB3_HUMAN	ephrin-B3	0					cell-cell signaling|interspecies interaction between organisms	integral to plasma membrane	ephrin receptor binding|transmembrane-ephrin receptor activity			large_intestine(3)|lung(2)|ovary(1)|prostate(1)|urinary_tract(1)	8		all_cancers(10;1.14e-06)|Prostate(122;0.081)				TACAAGGTATGAGGGCTCCTC	0.552000													25	3					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49422719	49422719	+	Nonsense_Mutation	SNP	A	A	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr12:49422719A>T	ENST00000301067.7	-	45	14273	c.14274T>A	c.(14272-14274)taT>taA	p.Y4758*		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		CAAGGGCCCCATAAGGTTTGG	0.547000													40	57					0	0	1	0	0
NTRK3	4916	broad.mit.edu	37	15	88678458	88678458	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr15:88678458C>T	ENST00000394480.2	-	10	1399	c.1078G>A	c.(1078-1080)Gag>Aag	p.E360K	NTRK3_ENST00000360948.2_Missense_Mutation_p.E360K|NTRK3_ENST00000557856.1_Missense_Mutation_p.E360K|NTRK3_ENST00000355254.2_Missense_Mutation_p.E360K|NTRK3_ENST00000540489.2_Missense_Mutation_p.E360K|NTRK3_ENST00000357724.2_Missense_Mutation_p.E360K|NTRK3_ENST00000317501.3_Missense_Mutation_p.E360K|NTRK3_ENST00000558676.1_Missense_Mutation_p.E360K|NTRK3_ENST00000542733.2_Missense_Mutation_p.E262K	NM_001243101.1|NM_002530.3	NP_001230030.1|NP_002521.2	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3		Ig-like C2-type 2.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(238)	breast(3)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(22)|lung(63)|ovary(6)|pancreas(3)|prostate(1)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)	119			BRCA - Breast invasive adenocarcinoma(143;0.211)			AGGCAGCCCTCGGAAATCTCT	0.552000			T	ETV6	"""congenital fibrosarcoma, Secretory breast """					TSP Lung(13;0.10)			49	8					0	0	1	0	0
KPNA2	3838	broad.mit.edu	37	17	66040130	66040130	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr17:66040130G>C	ENST00000537025.2	+	8	1727	c.1107G>C	c.(1105-1107)caG>caC	p.Q369H	KPNA2_ENST00000330459.3_Missense_Mutation_p.Q369H			P52292	IMA2_HUMAN	karyopherin alpha 2 (RAG cohort 1, importin alpha 1)	369	NLS binding site (minor) (By similarity).				DNA metabolic process|G2 phase of mitotic cell cycle|interspecies interaction between organisms|M phase specific microtubule process|NLS-bearing substrate import into nucleus|regulation of DNA recombination	cytoplasm|nuclear pore|nucleoplasm	histone deacetylase binding|nuclear localization sequence binding|protein transporter activity			breast(1)|central_nervous_system(2)|cervix(3)|endometrium(2)|kidney(2)|lung(9)|prostate(1)|urinary_tract(2)	22	all_cancers(12;1.18e-09)		BRCA - Breast invasive adenocarcinoma(8;1.03e-07)|LUSC - Lung squamous cell carcinoma(166;0.24)			GCCAGGACCAGATACAGCAAG	0.448000													81	91					0	0	1	0	0
NETO1	81832	broad.mit.edu	37	18	70532050	70532050	+	Silent	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr18:70532050G>A	ENST00000327305.6	-	3	870	c.213C>T	c.(211-213)atC>atT	p.I71I	NETO1_ENST00000397929.1_Silent_p.I70I|NETO1_ENST00000583169.1_Silent_p.I71I|NETO1_ENST00000299430.2_Silent_p.I70I|NETO1_ENST00000580049.1_5'UTR	NM_138966.3	NP_620416	Q8TDF5	NETO1_HUMAN	neuropilin (NRP) and tolloid (TLL)-like 1	71	CUB 1.				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			NS(3)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(36)|ovary(2)|prostate(3)|skin(3)|stomach(1)	63		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		TACCTTCTATGATGTAGATGC	0.468000													21	49					0	0	1	0	0
PLIN4	729359	broad.mit.edu	37	19	4512046	4512046	+	Silent	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr19:4512046C>T	ENST00000301286.3	-	3	1883	c.1884G>A	c.(1882-1884)gtG>gtA	p.V628V		NM_001080400.1	NP_001073869.1	Q96Q06	PLIN4_HUMAN	perilipin 4	628	27 X 33 AA approximate tandem repeat.					lipid particle|plasma membrane				NS(2)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|soft_tissue(1)|stomach(2)	41						TGGCCACGTTCACGGCACTGG	0.552000													85	77					0	0	1	0	0
PDE10A	10846	broad.mit.edu	37	6	165806202	165806202	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr6:165806202G>A	ENST00000366882.1	-	17	1713	c.1559C>T	c.(1558-1560)gCg>gTg	p.A520V	PDE10A_ENST00000539869.2_Missense_Mutation_p.A530V|PDE10A_ENST00000354448.4_Missense_Mutation_p.A520V			Q9Y233	PDE10_HUMAN	phosphodiesterase 10A	520					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding	p.A520V(1)		breast(4)|endometrium(5)|kidney(1)|large_intestine(13)|liver(1)|lung(39)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	71		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	TACAGTGACCGCATGCTTCCA	0.438000													4	69					0	0	1	0	0
GAS8	2622	broad.mit.edu	37	16	90099231	90099231	+	Missense_Mutation	SNP	C	C	T	rs149848921		TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr16:90099231C>T	ENST00000268699.4	+	4	516	c.394C>T	c.(394-396)Cgc>Tgc	p.R132C	GAS8_ENST00000536122.1_Missense_Mutation_p.R107C|GAS8_ENST00000540721.1_3'UTR	NM_001481.2	NP_001472.1	O95995	GAS8_HUMAN	growth arrest-specific 8	132	Microtubule-binding.				negative regulation of cell proliferation|sperm motility	cilium|Golgi apparatus|microtubule|microtubule basal body|microtubule-based flagellum	protein binding			endometrium(3)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	14		all_cancers(9;4.44e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.00118)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.029)		GAAAGAGCACCGCATACAGGA	0.557000													10	15					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13901514	13901514	+	Silent	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr5:13901514G>A	ENST00000265104.4	-	14	2003	c.1899C>T	c.(1897-1899)ctC>ctT	p.L633L		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	633	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TCCTATGGAAGAGCTGGCGGG	0.498000									Kartagener syndrome				23	22					0	0	1	0	0
REG1P	5969	broad.mit.edu	37	2	79363860	79363860	+	RNA	SNP	G	G	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr2:79363860G>T	ENST00000444841.1	-	0	478																											TGAGGTGCCAGACATCAGACC	0.428000													3	6					0.115264	0.115589	1	1	0
AADACL2	344752	broad.mit.edu	37	3	151475212	151475212	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr3:151475212G>A	ENST00000356517.3	+	5	1145	c.1036G>A	c.(1036-1038)Gat>Aat	p.D346N	RP11-454C18.2_ENST00000483843.2_RNA|RP11-454C18.2_ENST00000475855.1_RNA	NM_207365.3	NP_997248.2	Q6P093	ADCL2_HUMAN	arylacetamide deacetylase-like 2	346						extracellular region|integral to membrane	carboxylesterase activity			NS(1)|breast(1)|endometrium(2)|large_intestine(4)|liver(1)|lung(13)|skin(2)	24			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			CTTAAGAGATGATGGACTTAT	0.373000													55	31					0	0	1	0	0
NAV3	89795	broad.mit.edu	37	12	78604229	78604229	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr12:78604229A>T	ENST00000397909.2	+	40	7263	c.7090A>T	c.(7090-7092)Agc>Tgc	p.S2364C	NAV3_ENST00000541270.1_Missense_Mutation_p.S194C|NAV3_ENST00000228327.6_Missense_Mutation_p.S2342C|NAV3_ENST00000266692.7_Missense_Mutation_p.S2165C|NAV3_ENST00000536525.2_Missense_Mutation_p.S2342C			Q8IVL0	NAV3_HUMAN	neuron navigator 3	2364						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						GAGCACACAAAGCTGCGACAG	0.413000										HNSCC(70;0.22)			36	53					0	0	1	0	0
GPR63	81491	broad.mit.edu	37	6	97246651	97246651	+	Silent	SNP	G	G	C			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr6:97246651G>C	ENST00000229955.3	-	2	1302	c.957C>G	c.(955-957)ctC>ctG	p.L319L	GPR63_ENST00000417980.1_Silent_p.L319L	NM_001143957.2|NM_030784.3	NP_001137429.1|NP_110411.1	Q9BZJ6	GPR63_HUMAN	G protein-coupled receptor 63	319						integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			kidney(1)|large_intestine(5)|lung(13)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		all_cancers(76;6.89e-05)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.0618)|Colorectal(196;0.0721)		BRCA - Breast invasive adenocarcinoma(108;0.0912)		AGACAGCAAAGAGAATCAAAA	0.453000													21	21					0	0	1	0	0
BTBD10	84280	broad.mit.edu	37	11	13424777	13424777	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr11:13424777C>G	ENST00000278174.5	-	8	1300	c.1055G>C	c.(1054-1056)aGa>aCa	p.R352T	BTBD10_ENST00000530907.1_Missense_Mutation_p.R360T|BTBD10_ENST00000528120.1_Missense_Mutation_p.R304T	NM_032320.5	NP_115696.2	Q9BSF8	BTBDA_HUMAN	BTB (POZ) domain containing 10	352						nucleus				cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(7)|prostate(1)	20				Epithelial(150;0.0214)		GGCCACATCTCTGTTTTCAAT	0.254000													27	91					0	0	1	0	0
TMEM203	94107	broad.mit.edu	37	9	140099698	140099698	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr9:140099698C>A	ENST00000343666.5	-	1	392	c.169G>T	c.(169-171)Gac>Tac	p.D57Y	TMEM203_ENST00000537254.1_Missense_Mutation_p.D57Y	NM_053045.1	NP_444273.1	Q969S6	TM203_HUMAN	transmembrane protein 203	57						integral to membrane				central_nervous_system(1)|kidney(1)	2	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)		CTGAGCCCGTCAGCGGCGAAG	0.627000													7	27					2.0095e-06	2.06758e-06	1	1	0
PTPN21	11099	broad.mit.edu	37	14	88945788	88945788	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr14:88945788C>T	ENST00000556564.1	-	13	2271	c.1987G>A	c.(1987-1989)Gag>Aag	p.E663K	PTPN21_ENST00000328736.3_Missense_Mutation_p.E663K	NM_007039.3	NP_008970.2	Q16825	PTN21_HUMAN	protein tyrosine phosphatase, non-receptor type 21	663						cytoplasm|cytoskeleton	binding|protein tyrosine phosphatase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|liver(1)|lung(7)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	45						GGCGCCACCTCTGCCGCCGAC	0.706000													15	10					0	0	1	0	0
PTPRU	10076	broad.mit.edu	37	1	29609408	29609408	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr1:29609408G>C	ENST00000373779.3	+	12	2218	c.2089G>C	c.(2089-2091)Gag>Cag	p.E697Q	PTPRU_ENST00000460170.2_Missense_Mutation_p.E697Q|PTPRU_ENST00000428026.2_Missense_Mutation_p.E697Q|PTPRU_ENST00000323874.8_Missense_Mutation_p.E697Q|PTPRU_ENST00000345512.3_Missense_Mutation_p.E697Q|PTPRU_ENST00000356870.3_Missense_Mutation_p.E697Q|PTPRU_ENST00000415600.2_3'UTR	NM_001195001.1|NM_133178.3	NP_001181930.1|NP_573439.2	Q92729	PTPRU_HUMAN	protein tyrosine phosphatase, receptor type, U	697					canonical Wnt receptor signaling pathway|cell differentiation|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transmembrane receptor protein tyrosine phosphatase signaling pathway	cell-cell junction|integral to plasma membrane	beta-catenin binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(26)|ovary(1)|prostate(3)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	79		Colorectal(325;0.000399)|Lung NSC(340;0.00953)|all_lung(284;0.0112)|Breast(348;0.0126)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;6.99e-07)|COAD - Colon adenocarcinoma(152;3.18e-05)|STAD - Stomach adenocarcinoma(196;0.0234)|READ - Rectum adenocarcinoma(331;0.0686)|BRCA - Breast invasive adenocarcinoma(304;0.0871)		CCCACCACTTGAGCCTAGGAA	0.627000													30	51					0	0	1	0	0
FAM69B	138311	broad.mit.edu	37	9	139617888	139617888	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr9:139617888G>T	ENST00000371691.1	+	3	1796	c.697G>T	c.(697-699)Gca>Tca	p.A233S	FAM69B_ENST00000371692.4_Missense_Mutation_p.A320S|SNHG7_ENST00000414282.1_RNA			Q5VUD6	FA69B_HUMAN	family with sequence similarity 69, member B	320						endoplasmic reticulum membrane|integral to membrane				NS(1)|endometrium(3)|large_intestine(2)|lung(1)|prostate(1)	8	all_cancers(76;0.0882)|all_epithelial(76;0.228)	Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;1.03e-05)|Epithelial(140;0.00013)		GCAGCAGGTGGCACCCGAGGC	0.662000													25	18					1.55469e-16	1.66208e-16	1	1	0
MUC4	4585	broad.mit.edu	37	3	195511900	195511900	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr3:195511900G>A	ENST00000463781.3	-	2	7010	c.6551C>T	c.(6550-6552)tCa>tTa	p.S2184L	MUC4_ENST00000475231.1_Missense_Mutation_p.S2184L|MUC4_ENST00000349607.4_Intron|MUC4_ENST00000346145.4_Intron	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	963					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		TGTGGATGCTGAGGAAGTGTC	0.592000													3	10					0	0	1	0	0
HLA-DMB	3109	broad.mit.edu	37	6	32905010	32905010	+	Silent	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr6:32905010C>T	ENST00000416244.2	-	3	755	c.561G>A	c.(559-561)ggG>ggA	p.G187G	HLA-DMB_ENST00000418107.2_Silent_p.G187G			P28068	DMB_HUMAN	major histocompatibility complex, class II, DM beta	187	Beta-2.|Ig-like C1-type.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	integral to membrane|late endosome membrane|lysosomal membrane|MHC class II protein complex				breast(1)|cervix(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	13						TGTAAGTGTCCCCGTAAGAGG	0.547000													37	27					0	0	1	0	0
LGR5	8549	broad.mit.edu	37	12	71966646	71966646	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr12:71966646G>A	ENST00000266674.5	+	13	1464	c.1153G>A	c.(1153-1155)Gaa>Aaa	p.E385K	LGR5_ENST00000540815.2_Missense_Mutation_p.E361K|LGR5_ENST00000536515.1_Missense_Mutation_p.E313K			O75473	LGR5_HUMAN	leucine-rich repeat containing G protein-coupled receptor 5	385						integral to plasma membrane	protein-hormone receptor activity		NUP107/LGR5(2)	endometrium(2)|kidney(3)|large_intestine(2)|lung(24)|ovary(1)|pancreas(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	48						AAGACATAATGAAATCTACGA	0.413000													30	30					0	0	1	0	0
QRICH2	84074	broad.mit.edu	37	17	74287932	74287932	+	Missense_Mutation	SNP	C	C	T	rs151295247		TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr17:74287932C>T	ENST00000262765.5	-	4	2557	c.2378G>A	c.(2377-2379)cGt>cAt	p.R793H		NM_032134.1	NP_115510.1	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	793							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(2)|stomach(4)	62						CACCAGACCACGTGGATATGT	0.498000													53	74					0	0	1	0	0
BAZ2B	29994	broad.mit.edu	37	2	160310286	160310286	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr2:160310286G>A	ENST00000392783.2	-	4	667	c.172C>T	c.(172-174)Caa>Taa	p.Q58*	BAZ2B_ENST00000392782.1_Nonsense_Mutation_p.Q58*|BAZ2B_ENST00000355831.2_Nonsense_Mutation_p.Q58*|BAZ2B_ENST00000343439.5_Nonsense_Mutation_p.Q58*	NM_013450.2	NP_038478.2	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	58					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(7)|liver(2)|lung(41)|ovary(3)|prostate(1)|skin(2)|soft_tissue(1)|urinary_tract(1)	82						TTAAACGGTTGATCCCCAGCT	0.433000													15	11					0	0	1	0	0
NUDC	10726	broad.mit.edu	37	1	27267978	27267978	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr1:27267978C>T	ENST00000321265.5	+	3	313	c.190C>T	c.(190-192)Cag>Tag	p.Q64*		NM_006600.3	NP_006591.1	Q9Y266	NUDC_HUMAN	nudC nuclear distribution protein	64					cell proliferation|cytokinesis|mitotic prometaphase|multicellular organismal development	cytosol|microtubule|nucleoplasm	protein binding			cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|ovary(1)	8				UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;6.1e-51)|OV - Ovarian serous cystadenocarcinoma(117;2.87e-29)|Colorectal(126;5.74e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000281)|STAD - Stomach adenocarcinoma(196;0.000604)|KIRC - Kidney renal clear cell carcinoma(1967;0.000739)|READ - Rectum adenocarcinoma(331;0.0421)		CCACCACAATCAGCTGGCACA	0.642000													4	8					0	0	1	0	0
ZFHX3	463	broad.mit.edu	37	16	72832607	72832607	+	Nonsense_Mutation	SNP	G	G	C			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr16:72832607G>C	ENST00000268489.5	-	9	4646	c.3974C>G	c.(3973-3975)tCa>tGa	p.S1325*	ZFHX3_ENST00000397992.5_Nonsense_Mutation_p.S411*	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	1325					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				CAGATCCTCTGAGGTTTCTGT	0.458000													18	10					0	0	1	0	0
ADAR	103	broad.mit.edu	37	1	154574831	154574831	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr1:154574831C>T	ENST00000368474.4	-	2	486	c.287G>A	c.(286-288)gGc>gAc	p.G96D	ADAR_ENST00000292205.5_Missense_Mutation_p.G139D|ADAR_ENST00000471068.1_5'UTR|ADAR_ENST00000368471.3_5'UTR	NM_001111.4|NM_015840.3|NM_015841.3	NP_001102|NP_056655.2|NP_056656.2	P55265	DSRAD_HUMAN	adenosine deaminase, RNA-specific	96					adenosine to inosine editing|gene silencing by RNA|mRNA modification|mRNA processing|type I interferon-mediated signaling pathway	cytoplasm|nucleolus|nucleoplasm	DNA binding|double-stranded RNA adenosine deaminase activity|metal ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|lung(20)|ovary(4)|prostate(2)|skin(2)	51	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.0997)		LUSC - Lung squamous cell carcinoma(543;0.185)	Colorectal(1306;0.115)		GAGATGCACGCCCCTGGGGAC	0.587000													116	33					0	0	1	0	0
IRF9	10379	broad.mit.edu	37	14	24624500	24624500	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr14:24624500C>A	ENST00000558468.1	+	4	690	c.690C>A	c.(688-690)gaC>gaA	p.D230E	RNF31_ENST00000382687.3_Missense_Mutation_p.D604E|RNF31_ENST00000559275.1_Missense_Mutation_p.D604E|RNF31_ENST00000324103.6_Missense_Mutation_p.D755E																							TCACCGATGACACACAGTTGC	0.587000													10	46					1.76689e-08	1.85004e-08	1	1	0
MTOR	2475	broad.mit.edu	37	1	11187854	11187854	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr1:11187854C>G	ENST00000361445.4	-	44	6119	c.6043G>C	c.(6043-6045)Gag>Cag	p.E2015Q	MTOR_ENST00000376838.1_Missense_Mutation_p.E220Q	NM_004958.3	NP_004949.1	P42345	MTOR_HUMAN	mechanistic target of rapamycin (serine/threonine kinase)	2015					cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(7)|endometrium(20)|kidney(34)|large_intestine(21)|lung(43)|ovary(9)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	149						CGGATCAGCTCCTCGCTCACC	0.498000													72	80					0	0	1	0	0
UGT1A9	54600	broad.mit.edu	37	2	234581254	234581254	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr2:234581254A>G	ENST00000354728.4	+	1	756	c.674A>G	c.(673-675)aAa>aGa	p.K225R	UGT1A10_ENST00000373445.1_Intron|UGT1A10_ENST00000344644.5_Intron|UGT1A1_ENST00000373450.4_Intron|UGT1A1_ENST00000609637.1_Missense_Mutation_p.K225R																breast(2)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	37		Breast(86;0.000766)|all_lung(227;0.00269)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0331)|Lung NSC(271;0.0459)|Lung SC(224;0.128)		Epithelial(121;1.26e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000436)|Lung(119;0.00347)|LUSC - Lung squamous cell carcinoma(224;0.00757)		CGTTTTTTCAAAAATGCCCTA	0.418000													136	88					0	0	1	0	0
STAG3	10734	broad.mit.edu	37	7	99809157	99809157	+	Silent	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr7:99809157G>A	ENST00000426455.1	+	31	3917	c.3510G>A	c.(3508-3510)ctG>ctA	p.L1170L	STAG3_ENST00000440830.1_3'UTR|GATS_ENST00000543273.1_RNA|STAG3_ENST00000317296.5_Silent_p.L1170L|STAG3_ENST00000394018.2_Silent_p.L1112L|GATS_ENST00000436886.2_Intron	NM_001282716.1	NP_001269645.1	Q9UJ98	STAG3_HUMAN	stromal antigen 3	1170					chromosome segregation|synaptonemal complex assembly	chromosome, centromeric region|meiotic cohesin complex|synaptonemal complex	binding			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(3)|large_intestine(11)|lung(30)|ovary(5)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	66	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GCAACCAGCTGATGCGGTGAG	0.557000													73	41					0	0	1	0	0
SPEF2	79925	broad.mit.edu	37	5	35793429	35793429	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr5:35793429G>C	ENST00000440995.2	+	32	4708	c.4708G>C	c.(4708-4710)Gag>Cag	p.E1570Q	SPEF2_ENST00000303129.4_Missense_Mutation_p.E372Q|SPEF2_ENST00000356031.3_Missense_Mutation_p.E1575Q|CTD-2113L7.1_ENST00000510433.1_RNA			Q9C093	SPEF2_HUMAN	sperm flagellar 2	1575					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	37	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CATCACTTTTGAGCAGTATAT	0.468000													29	42					0	0	1	0	0
PYGL	5836	broad.mit.edu	37	14	51382160	51382160	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr14:51382160C>T	ENST00000216392.7	-	11	1629	c.1297G>A	c.(1297-1299)Gaa>Aaa	p.E433K	PYGL_ENST00000532462.1_Missense_Mutation_p.E433K|PYGL_ENST00000544180.2_Missense_Mutation_p.E399K	NM_002863.4	NP_002854.3	P06737	PYGL_HUMAN	phosphorylase, glycogen, liver	433					glucose homeostasis|glucose metabolic process|glycogen catabolic process	cytosol|soluble fraction	AMP binding|ATP binding|bile acid binding|drug binding|glucose binding|glycogen phosphorylase activity|protein homodimerization activity|purine base binding|pyridoxal phosphate binding			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(8)|prostate(1)|skin(3)	25	all_epithelial(31;0.00825)|Breast(41;0.148)				Adenosine monophosphate(DB00131)|Pyridoxal Phosphate(DB00114)|Riboflavin(DB00140)	CCTTCCTCTTCTATCAGAGAC	0.478000													30	52					0	0	1	0	0
SCN2A	6326	broad.mit.edu	37	2	166168552	166168552	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr2:166168552G>C	ENST00000357398.3	+	8	1278	c.988G>C	c.(988-990)Gag>Cag	p.E330Q	SCN2A_ENST00000375427.2_Missense_Mutation_p.E330Q|SCN2A_ENST00000375437.2_Missense_Mutation_p.E330Q|SCN2A_ENST00000283256.6_Missense_Mutation_p.E330Q			Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	330					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	TTATTTTTTAGAGGGGCAAAA	0.408000													15	29					0	0	1	0	0
BUB1	699	broad.mit.edu	37	2	111425132	111425132	+	Silent	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr2:111425132C>T	ENST00000535254.1	-	7	778	c.711G>A	c.(709-711)caG>caA	p.Q237Q	BUB1_ENST00000302759.6_Silent_p.Q257Q|BUB1_ENST00000409311.1_Silent_p.Q257Q	NM_001278616.1	NP_001265545.1	O43683	BUB1_HUMAN	BUB1 mitotic checkpoint serine/threonine kinase	257	Necessary for interaction with BUB3.				apoptosis|cell division|chromosome segregation|interspecies interaction between organisms|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|regulation of sister chromatid cohesion	condensed chromosome kinetochore|cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			breast(3)|endometrium(8)|kidney(4)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|stomach(1)	45		Ovarian(717;0.0822)		BRCA - Breast invasive adenocarcinoma(221;0.0556)		GATTGTATTTCTGGGCTCTCA	0.368000													47	24					0	0	1	0	0
PLIN4	729359	broad.mit.edu	37	19	4510957	4510957	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr19:4510957C>T	ENST00000301286.3	-	3	2972	c.2973G>A	c.(2971-2973)atG>atA	p.M991I		NM_001080400.1	NP_001073869.1	Q96Q06	PLIN4_HUMAN	perilipin 4	991						lipid particle|plasma membrane				NS(2)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|soft_tissue(1)|stomach(2)	41						TGGCCATGCTCATGGCACCGG	0.617000													20	17					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168108071	168108071	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr2:168108071C>G	ENST00000409195.1	+	9	10258	c.10169C>G	c.(10168-10170)tCt>tGt	p.S3390C	XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409273.1_Missense_Mutation_p.S3168C|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.S3390C|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000420519.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	3215					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						ACAGACTTTTCTTGCAAACAT	0.393000													55	34					0	0	1	0	0
MAP3K11	4296	broad.mit.edu	37	11	65365763	65365763	+	Nonstop_Mutation	SNP	C	C	G			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr11:65365763C>G	ENST00000309100.3	-	10	3028	c.2543G>C	c.(2542-2544)tGa>tCa	p.*848S	MAP3K11_ENST00000530153.1_Nonstop_Mutation_p.*591S|MAP3K11_ENST00000532507.1_Nonstop_Mutation_p.*264S	NM_002419.3	NP_002410.1	Q16584	M3K11_HUMAN	mitogen-activated protein kinase kinase kinase 11	0					activation of JUN kinase activity|cell proliferation|G1 phase of mitotic cell cycle|microtubule-based process|positive regulation of JNK cascade|protein autophosphorylation	centrosome|microtubule	ATP binding|JUN kinase kinase kinase activity|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity			breast(3)|central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(14)|skin(1)	24						CTGGCCCACTCAAGGCCCCGC	0.667000													2	1					0	0	1	0	0
CLEC14A	161198	broad.mit.edu	37	14	38724400	38724400	+	Silent	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr14:38724400G>A	ENST00000342213.2	-	1	1174	c.828C>T	c.(826-828)ggC>ggT	p.G276G		NM_175060.2	NP_778230.1	Q86T13	CLC14_HUMAN	C-type lectin domain family 14, member A	276	EGF-like.					integral to membrane	sugar binding			breast(1)|cervix(2)|endometrium(2)|large_intestine(7)|lung(9)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	33	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00439)		CCAGCTCGAAGCCCGTAGCAC	0.672000													46	31					0	0	1	0	0
PCDHB16	57717	broad.mit.edu	37	5	140563928	140563928	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr5:140563928G>C	ENST00000361016.2	+	1	2949	c.1794G>C	c.(1792-1794)caG>caC	p.Q598H		NM_020957.1	NP_066008.1	Q9NRJ7	PCDBG_HUMAN		598	Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(1)|endometrium(10)|kidney(3)|large_intestine(14)|lung(29)|ovary(5)|pancreas(2)|prostate(3)|skin(1)|urinary_tract(1)	69			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACTCGGGCCAGAATGCCTGGC	0.711000													79	35					0	0	1	0	0
TKT	7086	broad.mit.edu	37	3	53269121	53269121	+	Silent	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr3:53269121G>A	ENST00000462138.1	-	5	595	c.507C>T	c.(505-507)ttC>ttT	p.F169F	TKT_ENST00000423516.1_Silent_p.F177F|TKT_ENST00000423525.2_Silent_p.F169F|TKT_ENST00000296289.6_Silent_p.F122F			P29401	TKT_HUMAN	transketolase	169					energy reserve metabolic process|xylulose biosynthetic process	cytosol	protein binding|transketolase activity			endometrium(5)|large_intestine(4)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	17		Prostate(884;0.0959)		BRCA - Breast invasive adenocarcinoma(193;0.000159)|OV - Ovarian serous cystadenocarcinoma(275;0.000314)|Kidney(197;0.00178)|KIRC - Kidney renal clear cell carcinoma(197;0.00201)	Thiamine(DB00152)	AGATGCTGGCGAAGGCCATGG	0.582000													64	25					0	0	1	0	0
DPP10	57628	broad.mit.edu	37	2	116257166	116257166	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr2:116257166G>T	ENST00000410059.1	+	4	832	c.352G>T	c.(352-354)Gaa>Taa	p.E118*	DPP10_ENST00000409163.1_Nonsense_Mutation_p.E68*|DPP10_ENST00000488208.1_3'UTR|DPP10_ENST00000310323.8_Nonsense_Mutation_p.E111*|DPP10_ENST00000393147.2_Nonsense_Mutation_p.E122*	NM_001178037.1|NM_020868.3	NP_001171508.1|NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl-peptidase 10 (non-functional)	118					proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(24)|liver(2)|lung(48)|ovary(6)|prostate(1)|skin(5)|soft_tissue(1)	101						ATTATTATTGGAAAACACAAC	0.303000													38	17					4.14481e-20	4.45786e-20	1	1	0
RLTPR	146206	broad.mit.edu	37	16	67685873	67685873	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr16:67685873C>T	ENST00000334583.6	+	26	2966	c.2638C>T	c.(2638-2640)Cag>Tag	p.Q880*	RLTPR_ENST00000545661.1_Nonsense_Mutation_p.Q844*	NM_001013838.1	NP_001013860.1	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing	880										breast(1)|cervix(1)|endometrium(4)|kidney(1)|lung(9)|urinary_tract(2)	18		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)		CATTGTGGCTCAGGCTTTGGC	0.582000													21	40					0	0	1	0	0
CTD-3074O7.11	0	broad.mit.edu	37	11	66291252	66291252	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr11:66291252G>C	ENST00000419755.3	+	11	1198	c.1120G>C	c.(1120-1122)Gag>Cag	p.E374Q	BBS1_ENST00000393994.2_Intron|BBS1_ENST00000529766.1_3'UTR|ZDHHC24_ENST00000526986.1_Intron|BBS1_ENST00000455748.2_Missense_Mutation_p.E240Q|BBS1_ENST00000318312.7_Missense_Mutation_p.E337Q																							GAACCTCCTGGAGCAGCATTC	0.622000													11	13					0	0	1	0	0
MAFG	4097	broad.mit.edu	37	17	79880686	79880686	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr17:79880686G>A	ENST00000357736.4	-	3	499	c.284C>T	c.(283-285)tCa>tTa	p.S95L	MAFG_ENST00000392366.3_Missense_Mutation_p.S95L	NM_002359.3|NM_032711.3	NP_002350.1|NP_116100.2	O15525	MAFG_HUMAN	v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G	95	Leucine-zipper.				blood coagulation	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(1)|lung(1)	3	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.0165)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)			GGCGTTCTCTGAGGCCAGCTT	0.687000													3	7					0	0	1	0	0
SLC25A21	89874	broad.mit.edu	37	14	37198766	37198766	+	Silent	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr14:37198766G>A	ENST00000331299.5	-	5	791	c.276C>T	c.(274-276)ttC>ttT	p.F92F	SLC25A21_ENST00000555449.1_Silent_p.F92F	NM_030631.3	NP_085134.1	Q9BQT8	ODC_HUMAN	solute carrier family 25 (mitochondrial oxoadipate carrier), member 21	92					lysine catabolic process	integral to membrane|mitochondrial inner membrane	alpha-ketoglutarate transmembrane transporter activity|binding			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(2)|pancreas(1)|prostate(1)|skin(1)	9	Esophageal squamous(585;0.164)|Breast(36;0.179)|Hepatocellular(127;0.213)		Lung(8;2.16e-08)|LUAD - Lung adenocarcinoma(9;2.16e-07)|Epithelial(34;0.0112)|all cancers(34;0.0274)|LUSC - Lung squamous cell carcinoma(13;0.149)	GBM - Glioblastoma multiforme(112;0.00204)		GCTCAAAGGTGAAAAACTGTG	0.313000													30	24					0	0	1	0	0
TRIM4	89122	broad.mit.edu	37	7	99507267	99507267	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr7:99507267G>C	ENST00000355947.2	-	3	617	c.488C>G	c.(487-489)tCt>tGt	p.S163C	TRIM4_ENST00000349062.2_Missense_Mutation_p.S137C|TRIM4_ENST00000354241.5_Missense_Mutation_p.S137C	NM_033017.3	NP_148977.2	Q9C037	TRIM4_HUMAN	tripartite motif containing 4	163					protein trimerization	cytoplasm|plasma membrane	zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|skin(1)	17	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)	Ovarian(593;0.238)				ATTACGCTGAGACTTAAGAAG	0.393000													9	19					0	0	1	0	0
SF3B1	23451	broad.mit.edu	37	2	198266713	198266713	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr2:198266713C>T	ENST00000335508.6	-	15	2310	c.2219G>A	c.(2218-2220)gGa>gAa	p.G740E		NM_012433.2	NP_036565.2	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1, 155kDa						nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding	p.G740E(1)		NS(35)|breast(10)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(524)|kidney(4)|large_intestine(10)|lung(19)|ovary(1)|pancreas(4)|prostate(6)|salivary_gland(1)|skin(4)|testis(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	633			OV - Ovarian serous cystadenocarcinoma(117;0.246)			ATTTACCTTTCCTCTGTGTTG	0.343000			Mis		myelodysplastic syndrome								17	34					0	0	1	0	0
KCNJ9	3765	broad.mit.edu	37	1	160057420	160057420	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr1:160057420C>T	ENST00000368088.3	+	3	1237	c.995C>T	c.(994-996)tCg>tTg	p.S332L		NM_004983.2	NP_004974.2	Q92806	IRK9_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 9	332					synaptic transmission	integral to membrane|plasma membrane	G-protein activated inward rectifier potassium channel activity|protein binding	p.S332*(1)		biliary_tract(1)|endometrium(3)|large_intestine(3)|liver(1)|lung(5)|ovary(1)|skin(2)	16	all_cancers(52;5.86e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CCCACACCTTCGTGCAGTGCT	0.617000													26	125					0	0	1	0	0
ABCB8	11194	broad.mit.edu	37	7	150732784	150732784	+	Silent	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr7:150732784G>A	ENST00000358849.4	+	6	975	c.882G>A	c.(880-882)ctG>ctA	p.L294L	ABCB8_ENST00000477719.1_Silent_p.L294L|ABCB8_ENST00000477092.1_Silent_p.L294L|ABCB8_ENST00000542328.1_Silent_p.L206L|ABCB8_ENST00000498578.1_Silent_p.L294L|ABCB8_ENST00000356058.4_Silent_p.L331L|ABCB8_ENST00000297504.6_Silent_p.L311L	NM_001282291.1|NM_001282293.1|NM_007188.3	NP_001269220.1|NP_001269222.1|NP_009119.2	Q9NUT2	ABCB8_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 8	311	ABC transmembrane type-1.					ATP-binding cassette (ABC) transporter complex|integral to membrane|membrane fraction|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	26			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TGGGCACCCTGATGGGCTCAG	0.627000													26	22					0	0	1	0	0
TEX2	55852	broad.mit.edu	37	17	62290424	62290424	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr17:62290424G>A	ENST00000258991.3	-	2	1238	c.1154C>T	c.(1153-1155)tCc>tTc	p.S385F	TEX2_ENST00000583097.1_Missense_Mutation_p.S385F|TEX2_ENST00000584379.1_Missense_Mutation_p.S385F			Q8IWB9	TEX2_HUMAN	testis expressed 2	385					signal transduction|sphingolipid metabolic process	integral to membrane		p.S385F(1)		breast(3)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(15)|ovary(1)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(8;1.33e-10)	READ - Rectum adenocarcinoma(1115;0.0689)		GCTCCCCTGGGAACTTTTCAG	0.473000													53	52					0	0	1	0	0
PANX3	116337	broad.mit.edu	37	11	124481614	124481614	+	Silent	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr11:124481614C>T	ENST00000284288.2	+	1	229	c.162C>T	c.(160-162)ttC>ttT	p.F54F		NM_052959.2	NP_443191.1	Q96QZ0	PANX3_HUMAN	pannexin 3	54					protein hexamerization	gap junction|integral to membrane	gap junction hemi-channel activity|ion channel activity			NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(10)|prostate(2)|skin(2)|urinary_tract(1)	26	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0219)		CCCTGGCATTCGCCCAGGAGT	0.587000													13	25					0	0	1	0	0
HELZ2	85441	broad.mit.edu	37	20	62196494	62196494	+	Silent	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr20:62196494G>A	ENST00000467148.1	-	8	3750	c.3681C>T	c.(3679-3681)ttC>ttT	p.F1227F	HELZ2_ENST00000427522.2_Silent_p.F658F	NM_001037335.2	NP_001032412.2			helicase with zinc finger 2, transcriptional coactivator																		GCTCGGCCACGAAGATCTTGG	0.652000													4	7					0	0	1	0	0
ZNF138	7697	broad.mit.edu	37	7	64292137	64292137	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr7:64292137G>A	ENST00000359735.3	+	4	693	c.346G>A	c.(346-348)Gac>Aac	p.D116N	ZNF138_ENST00000440598.1_3'UTR|ZNF138_ENST00000440155.2_Missense_Mutation_p.D147N|ZNF138_ENST00000437743.1_Missense_Mutation_p.D141N|ZNF138_ENST00000430838.2_3'UTR|ZNF138_ENST00000307355.7_Missense_Mutation_p.D173N|ZNF138_ENST00000494380.1_3'UTR|ZNF138_ENST00000397136.2_Missense_Mutation_p.D116N	NM_001271637.1|NM_001271639.1	NP_001258566.1|NP_001258568.1	B4DP87	B4DP87_HUMAN	zinc finger protein 138	147					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			kidney(1)|large_intestine(3)|lung(2)|stomach(1)	7		Lung NSC(55;0.0795)|all_lung(88;0.18)				TAAAGAATGTGACAAATCACT	0.284000													21	53					0	0	1	0	0
PPP6R2	9701	broad.mit.edu	37	22	50882308	50882308	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr22:50882308G>T	ENST00000359139.3	+	22	2909	c.2515G>T	c.(2515-2517)Gac>Tac	p.D839Y	PPP6R2_ENST00000395744.3_Missense_Mutation_p.D838Y|PPP6R2_ENST00000395741.3_Missense_Mutation_p.D839Y|PPP6R2_ENST00000216061.5_Missense_Mutation_p.D872Y	NM_001242898.1|NM_001242899.1|NM_001242900.1|NM_014678.4	NP_001229827.1|NP_001229828.1|NP_001229829.1|NP_055493.2	O75170	PP6R2_HUMAN	protein phosphatase 6, regulatory subunit 2	872						cytoplasm|intracellular membrane-bounded organelle	protein binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(6)|ovary(2)|skin(1)|urinary_tract(1)	22						CGGGTGTGCTGACAGCCGGCT	0.657000													4	5					0.00909568	0.00922525	1	1	0
FAM13A	10144	broad.mit.edu	37	4	89859343	89859343	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr4:89859343T>C	ENST00000264344.5	-	5	862	c.655A>G	c.(655-657)Ata>Gta	p.I219V	FAM13A_ENST00000511976.1_Missense_Mutation_p.I10V|FAM13A_ENST00000502459.1_5'UTR|FAM13A_ENST00000509094.1_Missense_Mutation_p.I219V	NM_014883.3	NP_055698.2	O94988	FA13A_HUMAN	family with sequence similarity 13, member A	219	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|liver(1)|lung(22)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	55						TTAGCCATTATCTTGTTGCAC	0.393000													30	6					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24924112	24924112	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr15:24924112C>T	ENST00000329468.2	+	1	3572	c.3098C>T	c.(3097-3099)tCa>tTa	p.S1033L		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		AGTTCCACATCAGGAGAACTC	0.547000													28	6					0	0	1	0	0
KRAS	3845	broad.mit.edu	37	12	25398262	25398262	+	Missense_Mutation	SNP	C	C	G	rs121913538		TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr12:25398262C>G	ENST00000311936.3	-	2	248	c.57G>C	c.(55-57)ttG>ttC	p.L19F	KRAS_ENST00000256078.4_Missense_Mutation_p.L19F|KRAS_ENST00000556131.1_Missense_Mutation_p.L19F|KRAS_ENST00000557334.1_Missense_Mutation_p.L19F	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	19					activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.L19F(15)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCTGTATCGTCAAGGCACTCT	0.358000		119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			28	33					0	0	1	0	0
PATZ1	23598	broad.mit.edu	37	22	31740795	31740795	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr22:31740795C>T	ENST00000266269.5	-	1	1423	c.794G>A	c.(793-795)cGa>cAa	p.R265Q	PATZ1_ENST00000215919.3_Missense_Mutation_p.R265Q|PATZ1_ENST00000405309.3_Missense_Mutation_p.R265Q|PATZ1_ENST00000351933.4_Missense_Mutation_p.R265Q	NM_014323.2	NP_055138.2	Q9HBE1	PATZ1_HUMAN	POZ (BTB) and AT hook containing zinc finger 1	265					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R265Q(2)	EWSR1/PATZ1(2)	NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|skin(2)	12						GCCCCGGCCTCGCTTGCCAGT	0.652000													9	11					0	0	1	0	0
IKZF1	10320	broad.mit.edu	37	7	50467644	50467644	+	Silent	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr7:50467644C>T	ENST00000331340.3	+	8	1034	c.879C>T	c.(877-879)taC>taT	p.Y293Y	IKZF1_ENST00000343574.5_Silent_p.Y206Y|IKZF1_ENST00000359197.5_Silent_p.Y251Y|IKZF1_ENST00000357364.4_Silent_p.Y206Y|IKZF1_ENST00000440768.2_3'UTR|IKZF1_ENST00000439701.1_Silent_p.Y251Y|IKZF1_ENST00000346667.4_Silent_p.Y63Y|IKZF1_ENST00000438033.1_Silent_p.Y206Y|IKZF1_ENST00000349824.4_Silent_p.Y150Y	NM_001220769.1|NM_001220772.1|NM_001220773.1|NM_001220775.1|NM_006060.4	NP_001207698.1|NP_001207701.1|NP_001207702.1|NP_001207704.1|NP_006051.1	Q13422	IKZF1_HUMAN	IKAROS family zinc finger 1 (Ikaros)	293					cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding	p.?(28)		haematopoietic_and_lymphoid_tissue(275)|lung(1)	276	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				ACACGCCCTACGACAGCAGCG	0.622000			"""D,T"""	BCL6	"""ALL, DLBCL"""								5	9					0	0	1	0	0
ZNF330	27309	broad.mit.edu	37	4	142153687	142153687	+	Silent	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr4:142153687C>T	ENST00000262990.4	+	9	807	c.579C>T	c.(577-579)ttC>ttT	p.F193F	ZNF330_ENST00000421169.2_Silent_p.F133F	NM_014487.4	NP_055302.1	Q9Y3S2	ZN330_HUMAN	zinc finger protein 330	193						chromosome, centromeric region|midbody|nucleolus	protein binding|zinc ion binding			kidney(1)|large_intestine(4)|lung(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	14	all_hematologic(180;0.162)					AGGCTTGTTTCTGTGATGATC	0.318000													18	1					0	0	1	0	0
KIAA1407	57577	broad.mit.edu	37	3	113775288	113775288	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr3:113775288G>A	ENST00000295878.3	-	1	172	c.26C>T	c.(25-27)tCc>tTc	p.S9F	KIAA1407_ENST00000480588.1_5'UTR|KIAA1407_ENST00000545063.1_5'UTR	NM_020817.1	NP_065868.1	Q8NCU4	K1407_HUMAN	KIAA1407	9										endometrium(9)|large_intestine(7)|lung(19)|ovary(2)|pancreas(1)|prostate(1)|urinary_tract(1)	40						CTTTGAGAAGGACCTTCCCTG	0.602000													106	69					0	0	1	0	0
CHRNA7	1139	broad.mit.edu	37	15	32460267	32460267	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr15:32460267G>A	ENST00000306901.3	+	10	1214	c.1117G>A	c.(1117-1119)Gcc>Acc	p.A373T	CHRNA7_ENST00000454250.3_Missense_Mutation_p.A402T|CHRNA7_ENST00000455693.2_Missense_Mutation_p.A192T	NM_000746.5	NP_000737.1	P36544	ACHA7_HUMAN	cholinergic receptor, nicotinic, alpha 7 (neuronal)	373					activation of MAPK activity|calcium ion transport|cellular calcium ion homeostasis|memory|negative regulation of tumor necrosis factor production|positive regulation of angiogenesis|positive regulation of cell proliferation|response to hypoxia|response to nicotine	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|beta-amyloid binding|chloride channel regulator activity|nicotinic acetylcholine-activated cation-selective channel activity|protein homodimerization activity|toxin binding	p.A283S(1)|p.A373S(1)		endometrium(3)|large_intestine(1)|lung(6)|ovary(2)	12		all_lung(180;6.35e-11)		all cancers(64;3.34e-21)|Epithelial(43;2.64e-15)|GBM - Glioblastoma multiforme(186;5.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.00112)|Lung(196;0.227)	Nicotine(DB00184)|Varenicline(DB01273)	GGAGATGAGCGCCGTGGCGCC	0.706000													29	62					0	0	1	0	0
NCOR1	9611	broad.mit.edu	37	17	15965161	15965161	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr17:15965161G>A	ENST00000268712.3	-	37	5692	c.5435C>T	c.(5434-5436)tCc>tTc	p.S1812F	NCOR1_ENST00000395857.3_Missense_Mutation_p.S396F|NCOR1_ENST00000395851.1_Missense_Mutation_p.S1828F	NM_006311.3	NP_006302.2	O75376	NCOR1_HUMAN	nuclear receptor corepressor 1	1812	Interaction with C1D (By similarity).|Interaction with ETO.				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(26)|ovary(1)|prostate(7)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(10)	107				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		GTTGTAACGGGAGGCTGGCAG	0.527000													34	38					0	0	1	0	0
NR1D2	9975	broad.mit.edu	37	3	24018896	24018896	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr3:24018896A>C	ENST00000312521.4	+	8	2045	c.1726A>C	c.(1726-1728)Aaa>Caa	p.K576Q	NR1D2_ENST00000492552.1_3'UTR	NM_001145425.1|NM_005126.4	NP_001138897.1|NP_005117	Q14995	NR1D2_HUMAN	nuclear receptor subfamily 1, group D, member 2	576					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			NS(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(4)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	22						CTTGGCCTTTAAAGTTCACCC	0.358000													59	53					0	0	1	0	0
INHA	3623	broad.mit.edu	37	2	220440120	220440120	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr2:220440120C>G	ENST00000243786.2	+	2	1153	c.973C>G	c.(973-975)Cag>Gag	p.Q325E		NM_002191.3	NP_002182.1	P05111	INHA_HUMAN	inhibin, alpha	325					cell cycle arrest|cell surface receptor linked signaling pathway|cell-cell signaling|erythrocyte differentiation|hemoglobin biosynthetic process|induction of apoptosis|negative regulation of B cell differentiation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|ovarian follicle development|positive regulation of follicle-stimulating hormone secretion|regulation of cell proliferation|response to external stimulus|skeletal system development	inhibin A complex|inhibin-betaglycan-ActRII complex	cytokine activity|growth factor activity|hormone activity|signal transducer activity			large_intestine(2)|lung(5)|ovary(1)|skin(1)|urinary_tract(1)	10		Renal(207;0.0183)		Epithelial(149;4.58e-07)|all cancers(144;4.31e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		GCCAGGGGCCCAGCCCTGCTG	0.622000													47	43					0	0	1	0	0
PEPD	5184	broad.mit.edu	37	19	33878326	33878326	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr19:33878326G>A	ENST00000244137.7	-	15	1439	c.1406C>T	c.(1405-1407)cCc>cTc	p.P469L	PEPD_ENST00000591968.1_5'UTR|PEPD_ENST00000436370.3_Missense_Mutation_p.P405L|PEPD_ENST00000397032.4_Missense_Mutation_p.P428L	NM_000285.3	NP_000276.2	P12955	PEPD_HUMAN	peptidase D						cellular amino acid metabolic process|collagen catabolic process|proteolysis		aminopeptidase activity|dipeptidase activity|manganese ion binding|metallocarboxypeptidase activity			endometrium(3)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)	17	Esophageal squamous(110;0.137)					CACAGTGCGGGGCACGCAGGT	0.587000													30	62					0	0	1	0	0
RHOB	388	broad.mit.edu	37	2	20647310	20647310	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr2:20647310C>G	ENST00000272233.4	+	1	476	c.84C>G	c.(82-84)gaC>gaG	p.D28E		NM_004040.2	NP_004031.1	P62745	RHOB_HUMAN	ras homolog family member B	28					angiogenesis|axon guidance|cell adhesion|endosome to lysosome transport|negative regulation of cell cycle|platelet activation|positive regulation of angiogenesis|protein transport|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|transformed cell apoptosis	cytosol|late endosome membrane|nucleus|plasma membrane	GTP binding|GTPase activity|protein binding			breast(1)|kidney(1)|lung(2)|ovary(1)|urinary_tract(2)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)	all_epithelial(98;4.19e-09)|Lung NSC(108;0.00452)|Ovarian(717;0.0164)		OV - Ovarian serous cystadenocarcinoma(76;1.14e-22)|Epithelial(75;7.84e-19)		TCAGTAAGGACGAGTTCCCCG	0.662000													36	24					0	0	1	0	0
PGLYRP2	114770	broad.mit.edu	37	19	15582716	15582716	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr19:15582716C>T	ENST00000292609.4	-	3	1457	c.1328G>A	c.(1327-1329)gGa>gAa	p.G443E	PGLYRP2_ENST00000340880.4_Missense_Mutation_p.G443E			Q96PD5	PGRP2_HUMAN	peptidoglycan recognition protein 2	443					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptide amidation|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(3)|prostate(2)|skin(3)|stomach(2)|urinary_tract(1)	28						GCCGATGTCTCCCCAGCCTTG	0.692000													8	24					0	0	1	0	0
SETX	23064	broad.mit.edu	37	9	135153501	135153501	+	Silent	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr9:135153501G>A	ENST00000372169.2	-	21	6980	c.6798C>T	c.(6796-6798)ctC>ctT	p.L2266L	SETX_ENST00000393220.1_Silent_p.L2266L|SETX_ENST00000224140.5_Silent_p.L2266L			Q7Z333	SETX_HUMAN	senataxin	2266					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(1)|lung(36)|ovary(2)|prostate(2)|skin(1)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	97		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		TAGAAGGGAAGAGGCATATGT	0.388000													47	85					0	0	1	0	0
LRRC25	126364	broad.mit.edu	37	19	18502902	18502902	+	Silent	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr19:18502902G>A	ENST00000339007.3	-	2	1466	c.813C>T	c.(811-813)atC>atT	p.I271I	LRRC25_ENST00000595840.1_Silent_p.I271I	NM_145256.2	NP_660299.2	Q8N386	LRC25_HUMAN	leucine rich repeat containing 25	271						integral to membrane				endometrium(1)|large_intestine(3)|lung(3)|skin(1)	8						CCTTGTAGTTGATGTAAAAGT	0.582000													7	27					0	0	1	0	0
INADL	10207	broad.mit.edu	37	1	62579821	62579821	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr1:62579821G>T	ENST00000371158.2	+	35	4672	c.4558G>T	c.(4558-4560)Gag>Tag	p.E1520*	INADL_ENST00000543708.1_Nonsense_Mutation_p.E334*|INADL_ENST00000316485.6_Nonsense_Mutation_p.E1550*|INADL_ENST00000545929.1_Nonsense_Mutation_p.E165*	NM_176877.2	NP_795352	Q8NI35	INADL_HUMAN	InaD-like (Drosophila)	1520	PDZ 8.				intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(8)|liver(1)|lung(51)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)	103						GTATAGAGATGAGGCACACTA	0.577000													10	16					7.48243e-07	7.721e-07	1	1	0
TRPC4	7223	broad.mit.edu	37	13	38229288	38229288	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr13:38229288G>C	ENST00000379705.3	-	7	2678	c.1821C>G	c.(1819-1821)atC>atG	p.I607M	TRPC4_ENST00000447043.1_Missense_Mutation_p.I607M|TRPC4_ENST00000379679.1_Missense_Mutation_p.I434M|TRPC4_ENST00000379681.3_Missense_Mutation_p.I607M|TRPC4_ENST00000338947.5_Missense_Mutation_p.I434M|TRPC4_ENST00000379673.2_Missense_Mutation_p.I607M|TRPC4_ENST00000358477.2_Missense_Mutation_p.I607M|TRPC4_ENST00000426868.2_3'UTR|TRPC4_ENST00000355779.2_Missense_Mutation_p.I607M			Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel, subfamily C, member 4	607					axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity	p.I607I(2)		NS(2)|breast(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(26)|lung(30)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	83				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		CAACCAGAGAGATGACATTGT	0.353000													14	30					0	0	1	0	0
THAP7-AS1	439931	broad.mit.edu	37	22	21363368	21363368	+	RNA	SNP	C	C	G			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr22:21363368C>G	ENST00000452284.1	+	0	1035				THAP7-AS1_ENST00000436079.1_RNA|TUBA3FP_ENST00000422086.1_RNA	NR_027051.1																						GGAATTCTGTCAAGTACACAT	0.572000													19	37					0	0	1	0	0
INTS3	65123	broad.mit.edu	37	1	153719781	153719781	+	Silent	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr1:153719781G>A	ENST00000318967.2	+	5	1027	c.459G>A	c.(457-459)gtG>gtA	p.V153V	RP11-216N14.8_ENST00000453778.1_RNA|INTS3_ENST00000435409.2_Silent_p.V153V|INTS3_ENST00000456435.1_5'UTR	NM_023015.3	NP_075391.3	Q68E01	INT3_HUMAN	integrator complex subunit 3	153					DNA repair|G2/M transition checkpoint|response to ionizing radiation|snRNA processing	integrator complex|SOSS complex	protein binding			breast(1)|cervix(4)|endometrium(10)|kidney(1)|large_intestine(6)|lung(9)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	38	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GGGAACTGGTGAAGAGTGGGG	0.458000													50	17					0	0	1	0	0
SERPINE1	5054	broad.mit.edu	37	7	100776988	100776988	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr7:100776988C>T	ENST00000223095.4	+	5	870	c.713C>T	c.(712-714)aCg>aTg	p.T238M	SERPINE1_ENST00000445463.2_Missense_Mutation_p.T223M	NM_000602.4	NP_000593.1	P05121	PAI1_HUMAN	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	238					angiogenesis|cellular response to chemical stimulus|cellular response to lipopolysaccharide|chronological cell aging|defense response to Gram-negative bacterium|fibrinolysis|negative regulation of apoptosis|negative regulation of cell adhesion mediated by integrin|negative regulation of fibrinolysis|negative regulation of plasminogen activation|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell-matrix adhesion|negative regulation of vascular wound healing|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of interleukin-8 production|positive regulation of leukotriene production involved in inflammatory response|positive regulation of monocyte chemotaxis|positive regulation of receptor-mediated endocytosis|regulation of receptor activity	extracellular matrix|extracellular space|plasma membrane|platelet alpha granule lumen	protease binding|serine-type endopeptidase inhibitor activity			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|prostate(3)	20	Lung NSC(181;0.136)|all_lung(186;0.182)				Atorvastatin(DB01076)|Dimethyl sulfoxide(DB01093)|Drotrecogin alfa(DB00055)|Simvastatin(DB00641)|Tenecteplase(DB00031)|Troglitazone(DB00197)|Urokinase(DB00013)	GAGTTCACCACGCCCGATGGC	0.542000													9	47					0	0	1	0	0
ADCY9	115	broad.mit.edu	37	16	4039033	4039033	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr16:4039033C>T	ENST00000294016.3	-	6	2810	c.2272G>A	c.(2272-2274)Gag>Aag	p.E758K		NM_001116.3	NP_001107.2	O60503	ADCY9_HUMAN	adenylate cyclase 9	758					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(11)|lung(9)|ovary(5)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	47						CGCTCCAGCTCCTGATCCAGG	0.438000													67	32					0	0	1	0	0
THBS2	7058	broad.mit.edu	37	6	169633085	169633085	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr6:169633085G>A	ENST00000366787.3	-	12	1928	c.1679C>T	c.(1678-1680)cCg>cTg	p.P560L	XXyac-YX65C7_A.2_ENST00000444188.1_RNA	NM_003247.2	NP_003238.2	P35442	TSP2_HUMAN	thrombospondin 2	560	EGF-like 1.				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			NS(3)|biliary_tract(1)|endometrium(8)|kidney(3)|large_intestine(23)|liver(1)|lung(56)|ovary(6)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	111		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		CTGGGCTCCCGGGAAGCAGGG	0.657000													2	0					0	0	1	0	0
ANGEL1	23357	broad.mit.edu	37	14	77275974	77275974	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr14:77275974G>A	ENST00000251089.2	-	2	189	c.77C>T	c.(76-78)aCa>aTa	p.T26I	ANGEL1_ENST00000554941.1_5'UTR	NM_015305.3	NP_056120.2	Q9UNK9	ANGE1_HUMAN	angel homolog 1 (Drosophila)	26										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(2)|lung(9)|ovary(2)|skin(1)|stomach(1)|urinary_tract(1)	22			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0285)		TTTTCGACATGTGAAGAAAGC	0.502000													21	22					0	0	1	0	0
ABCA9	10350	broad.mit.edu	37	17	67023473	67023473	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr17:67023473G>A	ENST00000340001.4	-	14	2120	c.1909C>T	c.(1909-1911)Caa>Taa	p.Q637*	ABCA9_ENST00000453985.2_Nonsense_Mutation_p.Q637*|ABCA9_ENST00000370732.2_Nonsense_Mutation_p.Q637*	NM_080283.3	NP_525022.2	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 9	637	ABC transporter 1.				transport	integral to membrane	ATP binding|ATPase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(21)|lung(35)|ovary(4)|prostate(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	91	Breast(10;1.47e-12)					TGACTTACTTGAGGATCTCCT	0.294000													21	20					0	0	1	0	0
GTF3C3	9330	broad.mit.edu	37	2	197664309	197664309	+	Silent	SNP	G	G	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr2:197664309G>T	ENST00000263956.3	-	1	116	c.27C>A	c.(25-27)atC>atA	p.I9I	GTF3C3_ENST00000409364.3_Silent_p.I9I	NM_012086.4	NP_036218.1	Q9Y5Q9	TF3C3_HUMAN	general transcription factor IIIC, polypeptide 3, 102kDa	9						transcription factor TFIIIC complex	DNA binding|protein binding			breast(4)|endometrium(3)|kidney(1)|large_intestine(9)|lung(5)|ovary(3)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	33						CCAAGTAGTCGATGAGTTCCG	0.547000													14	57					6.31663e-08	6.5752e-08	1	1	0
SORCS1	114815	broad.mit.edu	37	10	108377934	108377934	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr10:108377934G>T	ENST00000263054.6	-	21	2900	c.2893C>A	c.(2893-2895)Caa>Aaa	p.Q965K	SORCS1_ENST00000344440.6_Missense_Mutation_p.Q965K|SORCS1_ENST00000478809.2_5'UTR|SORCS1_ENST00000369698.1_Missense_Mutation_p.Q500K	NM_001206570.1|NM_052918.4	NP_001193499.1|NP_443150.3	Q8WY21	SORC1_HUMAN	sortilin-related VPS10 domain containing receptor 1	965						integral to membrane	neuropeptide receptor activity|protein binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(9)|kidney(2)|large_intestine(24)|lung(69)|ovary(1)|prostate(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	127		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		TTTGTGTCTTGTAGGATGGCA	0.473000													45	28					3.77016e-25	4.092e-25	1	1	0
POLL	27343	broad.mit.edu	37	10	103343319	103343319	+	Silent	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr10:103343319G>A	ENST00000370162.3	-	6	1505	c.1011C>T	c.(1009-1011)ctC>ctT	p.L337L	POLL_ENST00000436284.2_3'UTR|POLL_ENST00000339310.3_Silent_p.L60L|DPCD_ENST00000470165.1_Intron|POLL_ENST00000456836.2_Silent_p.L74L|POLL_ENST00000370158.3_Silent_p.L62L|POLL_ENST00000370169.1_Silent_p.L337L|POLL_ENST00000370172.1_Silent_p.L249L|POLL_ENST00000299206.4_Silent_p.L337L|DPCD_ENST00000416979.2_Intron	NM_001174084.1|NM_001174085.1|NM_013274.3	NP_001167555.1|NP_001167556.1|NP_037406.1	Q9UGP5	DPOLL_HUMAN	polymerase (DNA directed), lambda	337					DNA replication|nucleotide-excision repair|somatic hypermutation of immunoglobulin genes	nucleus	DNA binding|DNA-directed DNA polymerase activity|lyase activity|metal ion binding			biliary_tract(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(2)|lung(7)|upper_aerodigestive_tract(2)	19		Colorectal(252;0.234)		Epithelial(162;1.55e-08)|all cancers(201;6.64e-07)		TGTTGGAGAAGAGCTCCAAGA	0.547000								DNA polymerases (catalytic subunits)					28	18					0	0	1	0	0
BRD8	10902	broad.mit.edu	37	5	137498964	137498964	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr5:137498964C>T	ENST00000254900.5	-	15	2313	c.1942G>A	c.(1942-1944)Gag>Aag	p.E648K	BRD8_ENST00000230901.5_Missense_Mutation_p.E721K|BRD8_ENST00000411594.2_Missense_Mutation_p.E651K|BRD8_ENST00000515014.1_Intron|BRD8_ENST00000455658.2_Missense_Mutation_p.E607K|BRD8_ENST00000402931.1_Missense_Mutation_p.E648K	NM_139199.1	NP_631938	Q9H0E9	BRD8_HUMAN	bromodomain containing 8	648					cell surface receptor linked signaling pathway|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription from RNA polymerase II promoter	mitochondrion|NuA4 histone acetyltransferase complex	sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(9)|ovary(1)|prostate(1)|skin(1)|stomach(3)|urinary_tract(1)	35			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			CCTTGATCCTCTTCCTTAGGC	0.488000													23	36					0	0	1	0	0
PAFAH2	5051	broad.mit.edu	37	1	26301079	26301079	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr1:26301079C>T	ENST00000374282.3	-	9	1000	c.821G>A	c.(820-822)cGa>cAa	p.R274Q	PAFAH2_ENST00000374284.1_Missense_Mutation_p.R274Q	NM_000437.3	NP_000428.2	Q99487	PAFA2_HUMAN	platelet-activating factor acetylhydrolase 2, 40kDa	274					lipid catabolic process	cytoplasm	1-alkyl-2-acetylglycerophosphocholine esterase activity|phospholipid binding			NS(1)|kidney(2)|large_intestine(2)|lung(1)|ovary(2)|urinary_tract(1)	9		Colorectal(325;3.47e-05)|Lung NSC(340;6.23e-05)|all_lung(284;9.48e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;3.84e-25)|Colorectal(126;3.57e-08)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|BRCA - Breast invasive adenocarcinoma(304;0.00105)|STAD - Stomach adenocarcinoma(196;0.00155)|GBM - Glioblastoma multiforme(114;0.00717)|READ - Rectum adenocarcinoma(331;0.0649)		CACAGGTCCTCGGGCCTTGGG	0.463000													13	25					0	0	1	0	0
CYP7A1	1581	broad.mit.edu	37	8	59404917	59404917	+	Missense_Mutation	SNP	G	G	A	rs144997923		TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr8:59404917G>A	ENST00000301645.3	-	5	1347	c.1210C>T	c.(1210-1212)Cct>Tct	p.P404S		NM_000780.3	NP_000771.2	P22680	CP7A1_HUMAN	cytochrome P450, family 7, subfamily A, polypeptide 1	404					bile acid biosynthetic process|cellular lipid metabolic process|cellular response to cholesterol|cellular response to glucose stimulus|cholesterol catabolic process|cholesterol homeostasis|regulation of bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholesterol 7-alpha-monooxygenase activity|electron carrier activity|heme binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|prostate(1)|urinary_tract(1)	34		all_lung(136;0.0271)|Lung NSC(129;0.0351)|all_epithelial(80;0.0554)				CTTACCAAAGGGTCTGGGTAG	0.388000									Neonatal Giant Cell Hepatitis				36	40					0	0	1	0	0
ZMYM4	9202	broad.mit.edu	37	1	35862221	35862221	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr1:35862221C>G	ENST00000314607.6	+	19	3060	c.2980C>G	c.(2980-2982)Ctt>Gtt	p.L994V	ZMYM4_ENST00000373297.2_Missense_Mutation_p.L905V	NM_005095.2	NP_005086.2	Q5VZL5	ZMYM4_HUMAN	zinc finger, MYM-type 4	994					multicellular organismal development		DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(16)|ovary(2)|prostate(3)|skin(2)	54		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				TCCCATACCTCTTCACCTTTA	0.398000													40	45					0	0	1	0	0
MTO1	25821	broad.mit.edu	37	6	74191937	74191937	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr6:74191937G>A	ENST00000498286.1	+	8	1712	c.1435G>A	c.(1435-1437)Gat>Aat	p.D479N	MTO1_ENST00000415954.2_Missense_Mutation_p.D519N|MTO1_ENST00000370305.1_Missense_Mutation_p.D430N|MTO1_ENST00000370300.4_Missense_Mutation_p.D504N			Q9Y2Z2	MTO1_HUMAN	mitochondrial tRNA translation optimization 1	504					tRNA processing	mitochondrion	flavin adenine dinucleotide binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|stomach(1)	27						ACTGCGCCCTGATAATGCTGA	0.507000													32	31					0	0	1	0	0
PCDHA3	56145	broad.mit.edu	37	5	140183224	140183224	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr5:140183224C>A	ENST00000532566.2	+	1	2442	c.2442C>A	c.(2440-2442)ttC>ttA	p.F814L	PCDHA2_ENST00000520672.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron	NM_031497.1	NP_113685.1														NS(1)|breast(1)|endometrium(16)|kidney(3)|large_intestine(19)|lung(36)|ovary(7)|prostate(8)|skin(3)|stomach(1)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTTTTTCATTCCTCAATGTTT	0.338000													8	28					0.0477658	0.0481717	1	1	0
MOB3C	148932	broad.mit.edu	37	1	47075816	47075816	+	Missense_Mutation	SNP	C	C	T	rs147799654		TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr1:47075816C>T	ENST00000371940.1	-	2	3622	c.548G>A	c.(547-549)cGa>cAa	p.R183Q	MOB3C_ENST00000477318.1_5'UTR|MOB3C_ENST00000271139.8_Missense_Mutation_p.R212Q|MKNK1_ENST00000545730.1_Intron|MOB3C_ENST00000319928.3_Missense_Mutation_p.R160Q			Q70IA8	MOL2C_HUMAN	MOB kinase activator 3C	160							metal ion binding										GACAAAGACTCGGAAGAGGCG	0.552000													59	30					0	0	1	0	0
FERMT3	83706	broad.mit.edu	37	11	63978229	63978229	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr11:63978229C>T	ENST00000279227.5	+	3	402	c.307C>T	c.(307-309)Cgg>Tgg	p.R103W	FERMT3_ENST00000345728.5_Missense_Mutation_p.R103W	NM_178443.2	NP_848537.1	Q86UX7	URP2_HUMAN	fermitin family member 3	103					integrin activation|leukocyte cell-cell adhesion|platelet aggregation|regulation of cell-cell adhesion mediated by integrin	cell junction|cell projection|podosome	integrin binding			breast(1)|cervix(1)|endometrium(4)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	18						CGTCATCCTTCGGTTGCCCAA	0.672000													71	72					0	0	1	0	0
SLC9A7P1	121456	broad.mit.edu	37	12	98850342	98850342	+	RNA	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr12:98850342G>A	ENST00000554295.1	-	0	581					NR_033801.1																						GAAGAATGTTGAAAAATACCT	0.428000													7	9					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103488462	103488462	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr1:103488462C>T	ENST00000358392.2	-	8	1434	c.1117G>A	c.(1117-1119)Gaa>Aaa	p.E373K	COL11A1_ENST00000370096.3_Missense_Mutation_p.E361K|COL11A1_ENST00000353414.4_Missense_Mutation_p.E322K|COL11A1_ENST00000512756.1_Intron	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	361	Nonhelical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TCTTTGTTTTCATATAGTGTA	0.323000													19	27					0	0	1	0	0
LTA4H	4048	broad.mit.edu	37	12	96418259	96418259	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr12:96418259C>G	ENST00000228740.2	-	4	619	c.478G>C	c.(478-480)Gag>Cag	p.E160Q	LTA4H_ENST00000552789.1_Missense_Mutation_p.E136Q|LTA4H_ENST00000413268.2_Missense_Mutation_p.E136Q	NM_000895.2	NP_000886.1	P09960	LKHA4_HUMAN	leukotriene A4 hydrolase	160					hormone biosynthetic process|inflammatory response|leukotriene biosynthetic process|peptide catabolic process|prostanoid metabolic process|proteolysis	cytosol|nucleus	aminopeptidase activity|epoxide hydrolase activity|leukotriene-A4 hydrolase activity|metallopeptidase activity|protein binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|kidney(3)|lung(4)|skin(2)|stomach(1)	12						ATATTTACCTCTGCAGTATAG	0.343000													8	15					0	0	1	0	0
CSGALNACT1	55790	broad.mit.edu	37	8	19297442	19297442	+	Splice_Site	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr8:19297442C>T	ENST00000454498.2	-	6	1865	c.852G>A	c.(850-852)agG>agA	p.R284R	CSGALNACT1_ENST00000522854.1_Splice_Site_p.R284R|CSGALNACT1_ENST00000544602.1_Splice_Site_p.R284R|CSGALNACT1_ENST00000332246.6_Splice_Site_p.R284R|CSGALNACT1_ENST00000518542.1_5'UTR|CSGALNACT1_ENST00000311540.4_Splice_Site_p.R284R	NM_001130518.1	NP_001123990.1	Q8TDX6	CGAT1_HUMAN	chondroitin sulfate N-acetylgalactosaminyltransferase 1	284					anatomical structure morphogenesis|cell proliferation|cell recognition|chondroitin sulfate biosynthetic process|chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|dermatan sulfate proteoglycan biosynthetic process|extracellular matrix organization|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|heparin biosynthetic process|nervous system development|UDP-glucuronate metabolic process|UDP-N-acetylgalactosamine metabolic process	Golgi cisterna membrane|integral to Golgi membrane|soluble fraction	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|glucuronosyltransferase activity|glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|peptidoglycan glycosyltransferase activity			NS(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31				Colorectal(111;0.182)		TGCACATCTCCCTGGAAAACA	0.413000													30	1					0	0	1	0	0
NDFIP1	80762	broad.mit.edu	37	5	141524185	141524185	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr5:141524185G>C	ENST00000253814.4	+	7	1082	c.612G>C	c.(610-612)aaG>aaC	p.K204N		NM_030571.3	NP_085048.1	Q9BT67	NFIP1_HUMAN	Nedd4 family interacting protein 1	204					cellular iron ion homeostasis|negative regulation of gene expression|negative regulation of protein transport|negative regulation of transporter activity|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of protein ubiquitination	endosome membrane|extracellular region|Golgi membrane|integral to membrane|perinuclear region of cytoplasm	signal transducer activity			large_intestine(3)|lung(1)|ovary(1)	5		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAGTTCGGAAGATGCCAGAAA	0.318000													33	79					0	0	1	0	0
TOMM40	10452	broad.mit.edu	37	19	45395666	45395666	+	Silent	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr19:45395666G>A	ENST00000592434.1	+	3	384	c.291G>A	c.(289-291)caG>caA	p.Q97Q	TOMM40_ENST00000426677.2_Silent_p.Q97Q|TOMM40_ENST00000405636.2_Silent_p.Q97Q|TOMM40_ENST00000252487.5_Silent_p.Q97Q			O96008	TOM40_HUMAN	translocase of outer mitochondrial membrane 40 homolog (yeast)	97					protein targeting to mitochondrion	integral to membrane of membrane fraction|integral to mitochondrial outer membrane|mitochondrial outer membrane translocase complex|pore complex	porin activity|protein transmembrane transporter activity|voltage-gated anion channel activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|lung(2)|ovary(1)	5	Lung NSC(12;0.0018)|all_lung(12;0.00481)			OV - Ovarian serous cystadenocarcinoma(262;0.0033)|Epithelial(262;0.176)		TTCCCATTCAGATGGAGGGTG	0.547000													34	55					0	0	1	0	0
PGBD2	267002	broad.mit.edu	37	1	249211438	249211438	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr1:249211438G>C	ENST00000539153.1	+	4	901	c.646G>C	c.(646-648)Gac>Cac	p.D216H	PGBD2_ENST00000462488.1_Intron|PGBD2_ENST00000329291.5_Missense_Mutation_p.D219H|PGBD2_ENST00000355360.4_Intron			Q6P3X8	PGBD2_HUMAN	piggyBac transposable element derived 2	219										NS(1)|endometrium(3)|lung(6)|ovary(1)|skin(3)	14	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.012)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			AATTAGAAGGGACAGATTTGA	0.408000													17	80					0	0	1	0	0
TAOK2	9344	broad.mit.edu	37	16	30002179	30002179	+	Silent	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr16:30002179C>T	ENST00000279394.3	+	18	2923	c.2520C>T	c.(2518-2520)ctC>ctT	p.L840L		NM_004783.3	NP_004774.1	Q9UL54	TAOK2_HUMAN	TAO kinase 2	721	Glu-rich.				actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|large_intestine(5)|lung(8)|ovary(1)|prostate(3)|skin(1)	22						TGGAGCTGCTCAACGCTTACC	0.617000													16	36					0	0	1	0	0
AP3B1	8546	broad.mit.edu	37	5	77590302	77590302	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr5:77590302G>C	ENST00000255194.6	-	1	277	c.102C>G	c.(100-102)ttC>ttG	p.F34L	AP3B1_ENST00000519295.1_5'UTR	NM_001271769.1	NP_001258698.1	O00203	AP3B1_HUMAN	adaptor-related protein complex 3, beta 1 subunit	34					endocytosis|melanosome organization	clathrin coated vesicle membrane|Golgi apparatus|membrane coat	protein phosphatase binding|protein transporter activity	p.F34F(1)		breast(5)|central_nervous_system(2)|cervix(1)|endometrium(3)|large_intestine(12)|lung(12)|prostate(1)|skin(2)|urinary_tract(1)	39		all_lung(232;0.000397)|Lung NSC(167;0.00106)|Ovarian(174;0.0105)|Prostate(461;0.215)		OV - Ovarian serous cystadenocarcinoma(54;8.23e-47)|Epithelial(54;2.74e-41)|all cancers(79;4.8e-36)		TAAAGAGGCCGAAGGCCCCCG	0.612000									Hermansky-Pudlak syndrome				22	5					0	0	1	0	0
ZNF703	80139	broad.mit.edu	37	8	37554779	37554779	+	Silent	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr8:37554779G>A	ENST00000331569.4	+	2	589	c.360G>A	c.(358-360)ctG>ctA	p.L120L		NM_025069.1	NP_079345.1	Q9H7S9	ZN703_HUMAN	zinc finger protein 703	120					adherens junction assembly|mammary gland epithelial cell differentiation|negative regulation of homotypic cell-cell adhesion|negative regulation of transcription, DNA-dependent|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of mammary gland epithelial cell proliferation|regulation of canonical Wnt receptor signaling pathway|regulation of cell cycle|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein binding|zinc ion binding		FGFR1/ZNF703(2)	breast(1)|cervix(1)|kidney(1)|large_intestine(2)|lung(1)|pancreas(1)	7			BRCA - Breast invasive adenocarcinoma(5;7.93e-25)|LUSC - Lung squamous cell carcinoma(8;1.05e-09)			CCAACGGGCTGGGAGCGGAGA	0.741000													8	1					0	0	1	0	0
NR3C2	4306	broad.mit.edu	37	4	149181140	149181140	+	Silent	SNP	T	T	C			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr4:149181140T>C	ENST00000355292.3	-	3	2249	c.1887A>G	c.(1885-1887)agA>agG	p.R629R	NR3C2_ENST00000512865.1_Silent_p.R629R|NR3C2_ENST00000358102.3_Silent_p.R629R|NR3C2_ENST00000511528.1_Silent_p.R629R|NR3C2_ENST00000344721.4_Silent_p.R629R			P08235	MCR_HUMAN	nuclear receptor subfamily 3, group C, member 2	629					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	endoplasmic reticulum membrane|nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(11)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	41	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0614)	Desoxycorticosterone Pivalate(DB01134)|Eplerenone(DB00700)|Fludrocortisone(DB00687)|Spironolactone(DB00421)	CTTCCACTGCTCTTTTGAAGA	0.403000													6	55					0	0	1	0	0
CILP2	148113	broad.mit.edu	37	19	19654143	19654143	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr19:19654143G>A	ENST00000586018.1	+	7	1184	c.1082G>A	c.(1081-1083)gGc>gAc	p.G361D	CILP2_ENST00000291495.5_Missense_Mutation_p.G355D			Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	355	Ig-like C2-type.					proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(17)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	32						GACCAGGCTGGCATCTACCAC	0.662000													36	26					0	0	1	0	0
ICOSLG	23308	broad.mit.edu	37	21	45655395	45655395	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr21:45655395C>T	ENST00000407780.3	-	4	584	c.457G>A	c.(457-459)Gag>Aag	p.E153K	ICOSLG_ENST00000344330.4_Missense_Mutation_p.E153K|ICOSLG_ENST00000400377.3_Missense_Mutation_p.E36K|ICOSLG_ENST00000400379.3_Missense_Mutation_p.E153K	NM_001283052.1	NP_001269981.1	O75144	ICOSL_HUMAN	inducible T-cell co-stimulator ligand	153	Ig-like C2-type.				B cell activation|defense response|hyperosmotic response|positive regulation of activated T cell proliferation|signal transduction|T cell activation|T cell costimulation		receptor binding			endometrium(2)|lung(1)|stomach(1)|urinary_tract(1)	5				Colorectal(79;0.0163)|READ - Rectum adenocarcinoma(84;0.0772)		AAGGTGAGCTCATCCTGGGAG	0.582000													41	63					0	0	1	0	0
UGGT1	56886	broad.mit.edu	37	2	128855037	128855037	+	Silent	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr2:128855037C>T	ENST00000375990.3	+	2	424	c.21C>T	c.(19-21)ctC>ctT	p.L7L	UGGT1_ENST00000259253.6_Silent_p.L31L			Q9NYU2	UGGG1_HUMAN	UDP-glucose glycoprotein glucosyltransferase 1	31					'de novo' posttranslational protein folding|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity|unfolded protein binding			NS(1)|breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(14)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	63						TGGTTGTACTCACTGTTCTGT	0.373000													47	35					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23902831	23902831	+	Silent	SNP	G	G	C			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr14:23902831G>C	ENST00000355349.3	-	3	273	c.111C>G	c.(109-111)gtC>gtG	p.V37V		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	37	Myosin head-like.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle	p.V37V(1)		NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		CAGGCACGAAGACATCCTTCT	0.572000													15	55					0	0	1	0	0
P2RY4	5030	broad.mit.edu	37	X	69479446	69479446	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chrX:69479446C>T	ENST00000374519.2	-	1	208	c.29G>A	c.(28-30)aGa>aAa	p.R10K		NM_002565.3	NP_002556.1	P51582	P2RY4_HUMAN	pyrimidinergic receptor P2Y, G-protein coupled, 4	10					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|elevation of cytosolic calcium ion concentration	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			cervix(2)|endometrium(2)|large_intestine(8)|lung(6)	18						GCCTAGGGATCTCAACAGGGA	0.592000													5	1					0	0	1	0	0
HECTD1	25831	broad.mit.edu	37	14	31585597	31585597	+	Silent	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr14:31585597C>T	ENST00000399332.1	-	30	5951	c.5463G>A	c.(5461-5463)ttG>ttA	p.L1821L	HECTD1_ENST00000553700.1_Silent_p.L1821L	NM_015382.2	NP_056197.2	Q9ULT8	HECD1_HUMAN	HECT domain containing E3 ubiquitin protein ligase 1	1821					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity	p.L1821F(1)		breast(10)|endometrium(7)|kidney(5)|large_intestine(12)|lung(23)|ovary(4)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	70	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		CTGTTACTTTCAAAGTGAGAG	0.393000													16	46					0	0	1	0	0
ATP2B1	490	broad.mit.edu	37	12	90024303	90024303	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr12:90024303C>T	ENST00000428670.3	-	6	1363	c.907G>A	c.(907-909)Gag>Aag	p.E303K	ATP2B1_ENST00000393164.2_Missense_Mutation_p.E46K|ATP2B1_ENST00000359142.3_Missense_Mutation_p.E303K|ATP2B1_ENST00000261173.2_Missense_Mutation_p.E303K|ATP2B1_ENST00000348959.3_Missense_Mutation_p.E303K			P20020	AT2B1_HUMAN	ATPase, Ca++ transporting, plasma membrane 1	303					ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(13)|lung(15)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	45						tttttcttctcatctttcttc	0.338000													12	16					0	0	1	0	0
NBPF14	25832	broad.mit.edu	37	1	148004675	148004675	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr1:148004675C>T	ENST00000369219.1	-	22	2655	c.2639G>A	c.(2638-2640)aGa>aAa	p.R880K				Q5TI25	NBPFE_HUMAN	neuroblastoma breakpoint family, member 14	880	NBPF 10.					cytoplasm				NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(1)|lung(23)|ovary(2)|pancreas(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(1)	42	all_hematologic(923;0.032)					AAACACACTTCTGTAGTGCTG	0.438000													25	178					0	0	1	0	0
KMT2A	4297	broad.mit.edu	37	11	118342446	118342446	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr11:118342446C>G	ENST00000534358.1	+	3	595	c.572C>G	c.(571-573)tCa>tGa	p.S191*	KMT2A_ENST00000389506.5_Nonsense_Mutation_p.S191*|KMT2A_ENST00000354520.4_Nonsense_Mutation_p.S191*	NM_001197104.1|NM_005933.3	NP_001184033.1|NP_005924.2			lysine (K)-specific methyltransferase 2A																		GCTATCCTCTCAGATCCATCT	0.378000													23	19					0	0	1	0	0
TUBA4A	7277	broad.mit.edu	37	2	220115591	220115591	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr2:220115591G>C	ENST00000392088.2	-	4	1340	c.785C>G	c.(784-786)tCt>tGt	p.S262C	TUBA4A_ENST00000248437.4_Missense_Mutation_p.S277C|TUBA4A_ENST00000498660.1_5'UTR	NM_001278552.1	NP_001265481.1	P68366	TBA4A_HUMAN	tubulin, alpha 4a	277					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|platelet activation|platelet degranulation|protein polymerization	cytosol|extracellular region|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(6)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	20		Renal(207;0.0474)		Epithelial(149;1.16e-06)|all cancers(144;0.000191)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CTTTTCTGCAGAGATGACTGG	0.582000													23	51					0	0	1	0	0
HDGFRP2	84717	broad.mit.edu	37	19	4501209	4501209	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr19:4501209C>G	ENST00000301284.4	+	15	1875	c.1811C>G	c.(1810-1812)tCa>tGa	p.S604*	HDGFRP2_ENST00000586684.1_Nonsense_Mutation_p.S604*	NM_001001520.1|NM_032631.2	NP_001001520|NP_116020.1	Q7Z4V5	HDGR2_HUMAN		599					transcription, DNA-dependent	nucleus	DNA binding|protein binding										CCAGATCTCTCAGCCCCAGTG	0.652000													21	9					0	0	1	0	0
PKN3	29941	broad.mit.edu	37	9	131469274	131469274	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr9:131469274G>A	ENST00000291906.4	+	5	1016	c.623G>A	c.(622-624)aGa>aAa	p.R208K		NM_013355.3	NP_037487.2	Q6P5Z2	PKN3_HUMAN	protein kinase N3	208					signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm	ATP binding|protein binding|protein kinase C activity			breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|pancreas(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	24						AGTAGCCGGAGAACACAGGAC	0.632000													29	34					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25448221	25448221	+	RNA	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr15:25448221G>A	ENST00000424208.1	+	0	2067				SNHG14_ENST00000424333.1_RNA	NR_003305.1																						TACTGGGGCCGCTGGCCCCAC	0.632000													17	4					0	0	1	0	0
UCKL1	54963	broad.mit.edu	37	20	62577866	62577866	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr20:62577866C>T	ENST00000369908.5	-	2	498	c.199G>A	c.(199-201)Gcc>Acc	p.A67T	UCKL1_ENST00000354216.6_Missense_Mutation_p.A82T|UCKL1_ENST00000369892.3_Missense_Mutation_p.A82T|UCKL1_ENST00000358711.3_Missense_Mutation_p.A82T	NM_001193379.1	NP_001180308.1	Q9NWZ5	UCKL1_HUMAN	uridine-cytidine kinase 1-like 1	82					interspecies interaction between organisms	endoplasmic reticulum|nucleus	ATP binding|phosphotransferase activity, alcohol group as acceptor|protein binding|uridine kinase activity			endometrium(3)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	8	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					GGCCGCCCGGCGGTGTAGATG	0.672000													13	18					0	0	1	0	0
LRP10	26020	broad.mit.edu	37	14	23344686	23344686	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr14:23344686G>C	ENST00000359591.4	+	5	1220	c.529G>C	c.(529-531)Gac>Cac	p.D177H	LRP10_ENST00000546834.1_Missense_Mutation_p.D177H	NM_014045.3	NP_054764.2	Q7Z4F1	LRP10_HUMAN	low density lipoprotein receptor-related protein 10	177					endocytosis	coated pit|integral to membrane				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(7)|ovary(2)|prostate(2)|skin(5)|stomach(1)|urinary_tract(2)	32	all_cancers(95;4.69e-05)			GBM - Glioblastoma multiforme(265;0.00549)		TTGCAGCTCAGACCCCTTCCC	0.572000													41	27					0	0	1	0	0
ZNF138	7697	broad.mit.edu	37	7	64291896	64291896	+	Silent	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr7:64291896G>A	ENST00000359735.3	+	4	452	c.105G>A	c.(103-105)gtG>gtA	p.V35V	ZNF138_ENST00000440598.1_3'UTR|ZNF138_ENST00000440155.2_Silent_p.V66V|ZNF138_ENST00000437743.1_Silent_p.V60V|ZNF138_ENST00000430838.2_3'UTR|ZNF138_ENST00000307355.7_Silent_p.V92V|ZNF138_ENST00000494380.1_3'UTR|ZNF138_ENST00000397136.2_Silent_p.V35V	NM_001271637.1|NM_001271639.1	NP_001258566.1|NP_001258568.1	B4DP87	B4DP87_HUMAN	zinc finger protein 138	66					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			kidney(1)|large_intestine(3)|lung(2)|stomach(1)	7		Lung NSC(55;0.0795)|all_lung(88;0.18)				TCCAAAAAGTGACACTGAGCA	0.368000													28	61					0	0	1	0	0
PIDD	55367	broad.mit.edu	37	11	799999	799999	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr11:799999C>T	ENST00000347755.5	-	15	2431	c.2290G>A	c.(2290-2292)Gag>Aag	p.E764K	PIDD_ENST00000411829.2_Missense_Mutation_p.E747K	NM_145886.3|NM_145887.3	NP_665893.2|NP_665894.2	Q9HB75	PIDD_HUMAN	p53-induced death domain protein	764					apoptosis|signal transduction	cytoplasm|nucleus	death receptor binding										CGTGGCCCCTCGGACCCTCGA	0.632000													10	10					0	0	1	0	0
CLCN3	1182	broad.mit.edu	37	4	170618377	170618377	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr4:170618377C>A	ENST00000513761.1	+	9	1614	c.1055C>A	c.(1054-1056)tCa>tAa	p.S352*	CLCN3_ENST00000504131.2_Nonsense_Mutation_p.S335*|CLCN3_ENST00000347613.4_Nonsense_Mutation_p.S352*|CLCN3_ENST00000360642.3_Nonsense_Mutation_p.S325*	NM_001829.3	NP_001820.2	P51790	CLCN3_HUMAN	chloride channel, voltage-sensitive 3	352					endosomal lumen acidification	cell surface|early endosome membrane|Golgi membrane|integral to membrane|late endosome membrane|transport vesicle membrane	antiporter activity|ATP binding|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|voltage-gated chloride channel activity			breast(5)|endometrium(3)|large_intestine(8)|lung(8)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	29		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0233)|LUSC - Lung squamous cell carcinoma(193;0.131)		TTATGGAGATCATTTTTTGCT	0.318000													45	8					1.62263e-30	1.77195e-30	1	1	0
PDS5B	23047	broad.mit.edu	37	13	33320191	33320191	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr13:33320191G>A	ENST00000315596.10	+	24	2875	c.2689G>A	c.(2689-2691)Gaa>Aaa	p.E897K		NM_015032.3	NP_055847.1	Q9NTI5	PDS5B_HUMAN	PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)	897					cell division|cell proliferation|mitotic sister chromatid cohesion|negative regulation of cell proliferation	chromatin|nucleus	ATP binding|DNA binding|identical protein binding			NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(14)|lung(14)|ovary(5)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	62		Lung SC(185;0.0367)		all cancers(112;5.55e-06)|Epithelial(112;2.7e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00303)|BRCA - Breast invasive adenocarcinoma(63;0.0204)		CTGTTACCATGAAATCATCAC	0.383000													34	27					0	0	1	0	0
OSBPL8	114882	broad.mit.edu	37	12	76780014	76780014	+	Silent	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr12:76780014G>A	ENST00000261183.3	-	14	1946	c.1467C>T	c.(1465-1467)ggC>ggT	p.G489G	OSBPL8_ENST00000393250.4_Silent_p.G447G|OSBPL8_ENST00000393249.2_Silent_p.G447G	NM_020841.4	NP_065892.1	Q9BZF1	OSBL8_HUMAN	oxysterol binding protein-like 8	489					lipid transport		lipid binding	p.G489G(1)		breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(14)|ovary(2)	28						GGAAAGTCTCGCCAAGTATAG	0.308000													29	41					0	0	1	0	0
NXPE2	120406	broad.mit.edu	37	11	114568875	114568875	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr11:114568875G>A	ENST00000375475.5	+	3	339	c.241G>A	c.(241-243)Gaa>Aaa	p.E81K	NXPE2_ENST00000389586.4_Missense_Mutation_p.E81K					neurexophilin and PC-esterase domain family, member 2																		AAAAGAGACTGAACTTAGAAT	0.438000													13	11					0	0	1	0	0
SLC9B1	150159	broad.mit.edu	37	4	103827759	103827759	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr4:103827759G>A	ENST00000296422.7	-	10	1270	c.1129C>T	c.(1129-1131)Caa>Taa	p.Q377*	SLC9B1_ENST00000394789.3_Nonsense_Mutation_p.Q377*|SLC9B1_ENST00000512651.2_Intron	NM_139173.3	NP_631912	Q4ZJI4	NHDC1_HUMAN	solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1	377						integral to membrane	solute:hydrogen antiporter activity										AGAAGTGGTTGAAAAATATCC	0.279000													26	7					0	0	1	0	0
PLIN4	729359	broad.mit.edu	37	19	4510759	4510759	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr19:4510759C>A	ENST00000301286.3	-	3	3170	c.3171G>T	c.(3169-3171)agG>agT	p.R1057S		NM_001080400.1	NP_001073869.1	Q96Q06	PLIN4_HUMAN	perilipin 4	1057						lipid particle|plasma membrane				NS(2)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|soft_tissue(1)|stomach(2)	41						TGTCTGTGGTCCTGGAACTGG	0.652000													21	17					7.41877e-09	7.79081e-09	1	1	0
SPATA20	64847	broad.mit.edu	37	17	48631805	48631805	+	Silent	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr17:48631805C>T	ENST00000006658.6	+	15	2271	c.2151C>T	c.(2149-2151)ctC>ctT	p.L717L	SPATA20_ENST00000393244.3_Silent_p.L657L|SPATA20_ENST00000511937.1_3'UTR|SPATA20_ENST00000356488.4_Silent_p.L701L	NM_022827.3	NP_073738.2	Q8TB22	SPT20_HUMAN	spermatogenesis associated 20	701					cell differentiation|mannose metabolic process|multicellular organismal development|spermatogenesis	extracellular region	mannose-6-phosphate isomerase activity|protein binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	24	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;9.38e-09)			AGCAGACCCTCAAGCAGGTGG	0.662000													18	29					0	0	1	0	0
MAFG	4097	broad.mit.edu	37	17	79880793	79880793	+	Silent	SNP	G	G	C			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr17:79880793G>C	ENST00000357736.4	-	3	392	c.177C>G	c.(175-177)ctC>ctG	p.L59L	MAFG_ENST00000392366.3_Silent_p.L59L|RP11-498C9.12_ENST00000580897.1_RNA	NM_002359.3|NM_032711.3	NP_002350.1|NP_116100.2	O15525	MAFG_HUMAN	v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G	59					blood coagulation	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(1)|lung(1)	3	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.0165)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)			CGCGGTTCTTGAGCGTGCGCC	0.657000													4	13					0	0	1	0	0
SLC6A1	6529	broad.mit.edu	37	3	11067216	11067216	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr3:11067216G>A	ENST00000287766.4	+	8	1217	c.796G>A	c.(796-798)Gag>Aag	p.E266K	SLC6A1_ENST00000536032.1_Missense_Mutation_p.E88K	NM_003042.3	NP_003033.3	P30531	SC6A1_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 1	266					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity	p.E266K(1)		breast(1)|endometrium(2)|large_intestine(6)|lung(6)|ovary(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)	26		Ovarian(110;0.0392)		OV - Ovarian serous cystadenocarcinoma(96;0.00099)	Cocaine(DB00907)|Tiagabine(DB00906)	CGGGGCCAAGGAGGGCATCCT	0.572000													30	39					0	0	1	0	0
KCNH4	23415	broad.mit.edu	37	17	40328187	40328187	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr17:40328187G>C	ENST00000264661.3	-	5	1046	c.714C>G	c.(712-714)ttC>ttG	p.F238L	KCNH4_ENST00000607371.1_Missense_Mutation_p.F238L	NM_012285.2	NP_036417.1	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 4	238					regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(15)|skin(2)|urinary_tract(1)	32		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		CCGCAACGTAGAAGGTGGCAA	0.607000													42	59					0	0	1	0	0
DACT1	51339	broad.mit.edu	37	14	59108358	59108358	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr14:59108358C>G	ENST00000395153.3	+	3	674	c.527C>G	c.(526-528)tCt>tGt	p.S176C	DACT1_ENST00000541264.2_5'UTR|DACT1_ENST00000556859.1_5'UTR|DACT1_ENST00000555845.1_3'UTR|DACT1_ENST00000335867.4_Missense_Mutation_p.S176C	NM_001079520.1|NM_016651.5	NP_001072988.1|NP_057735.2	Q9NYF0	DACT1_HUMAN	dishevelled-binding antagonist of beta-catenin 1	176					multicellular organismal development|Wnt receptor signaling pathway	cytoplasm|nucleus				endometrium(7)|kidney(3)|large_intestine(11)|lung(27)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	53						TCCAATTCCTCTAACTCGGTG	0.448000													58	42					0	0	1	0	0
TAF6L	10629	broad.mit.edu	37	11	62546432	62546432	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr11:62546432G>A	ENST00000294168.3	+	6	729	c.528G>A	c.(526-528)atG>atA	p.M176I	TMEM223_ENST00000527073.1_Intron	NM_006473.3	NP_006464.1	Q9Y6J9	TAF6L_HUMAN	TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa	176					chromatin remodeling|histone H3 acetylation|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	histone deacetylase complex|STAGA complex	DNA binding|protein binding|transcription coactivator activity			endometrium(2)|large_intestine(5)|lung(4)|ovary(3)|prostate(1)|skin(1)	16						CGCAACTGATGAAGGTGAGCG	0.463000													20	45					0	0	1	0	0
RSPH4A	345895	broad.mit.edu	37	6	116949065	116949065	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr6:116949065C>G	ENST00000229554.5	+	3	1332	c.1195C>G	c.(1195-1197)Cat>Gat	p.H399D	RSPH4A_ENST00000368580.4_Intron|RSPH4A_ENST00000368581.4_Missense_Mutation_p.H399D	NM_001010892.2	NP_001010892.1	Q5TD94	RSH4A_HUMAN	radial spoke head 4 homolog A (Chlamydomonas)	399	Glu-rich.				cilium axoneme assembly|cilium movement	cytoplasm|cytoskeleton|radial spoke				breast(1)|endometrium(2)|kidney(1)|large_intestine(11)|lung(8)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27						aagtgaagctcatgaagatga	0.413000									Kartagener syndrome				24	25					0	0	1	0	0
ATAD5	79915	broad.mit.edu	37	17	29161548	29161548	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr17:29161548A>C	ENST00000321990.4	+	2	827	c.449A>C	c.(448-450)gAt>gCt	p.D150A	CTD-2349P21.11_ENST00000580873.1_RNA	NM_024857.3	NP_079133.3	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	150					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(3)|large_intestine(18)|lung(13)|ovary(3)|pancreas(1)	51		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				TTAAATAATGATTTTGTGGAA	0.294000													46	183					0	0	1	0	0
MTO1	25821	broad.mit.edu	37	6	74191946	74191946	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr6:74191946G>A	ENST00000498286.1	+	8	1721	c.1444G>A	c.(1444-1446)Gac>Aac	p.D482N	MTO1_ENST00000415954.2_Missense_Mutation_p.D522N|MTO1_ENST00000370305.1_Missense_Mutation_p.D433N|MTO1_ENST00000370300.4_Missense_Mutation_p.D507N			Q9Y2Z2	MTO1_HUMAN	mitochondrial tRNA translation optimization 1	507					tRNA processing	mitochondrion	flavin adenine dinucleotide binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|stomach(1)	27						TGATAATGCTGACAGCCGGCT	0.517000													30	31					0	0	1	0	0
B4GALNT2	124872	broad.mit.edu	37	17	47246260	47246260	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr17:47246260C>T	ENST00000300404.2	+	10	1552	c.1493C>T	c.(1492-1494)tCa>tTa	p.S498L	B4GALNT2_ENST00000504681.1_Missense_Mutation_p.S412L|B4GALNT2_ENST00000393354.2_Missense_Mutation_p.S438L	NM_153446.2	NP_703147.2	Q8NHY0	B4GN2_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 2	498					lipid glycosylation|negative regulation of cell-cell adhesion|UDP-N-acetylgalactosamine metabolic process	integral to Golgi membrane	acetylgalactosaminyltransferase activity			endometrium(3)|large_intestine(6)|liver(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	24			all cancers(6;0.000316)			GTGGCTCACTCAGGTGGGAAG	0.577000													8	19					0	0	1	0	0
LRRC8A	56262	broad.mit.edu	37	9	131671124	131671124	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr9:131671124G>A	ENST00000259324.5	+	3	2204	c.1681G>A	c.(1681-1683)Gtg>Atg	p.V561M	LRRC8A_ENST00000372600.4_Missense_Mutation_p.V561M|LRRC8A_ENST00000372599.3_Missense_Mutation_p.V561M	NM_001127244.1	NP_001120716.1	Q8IWT6	LRC8A_HUMAN	leucine rich repeat containing 8 family, member A	561					pre-B cell differentiation	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|skin(3)	28						GCTGCCACAGGTGGTCACAGA	0.582000													16	35					0	0	1	0	0
PPARGC1A	10891	broad.mit.edu	37	4	23816119	23816119	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr4:23816119C>G	ENST00000264867.2	-	8	1106	c.987G>C	c.(985-987)aaG>aaC	p.K329N	PPARGC1A_ENST00000509702.1_5'UTR	NM_013261.3	NP_037393.1	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	329	Interaction with PPARG.				androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|liver(1)|lung(24)|ovary(3)|skin(5)	51		Breast(46;0.0503)				ACCTGGGCTTCTTTGATGGTG	0.507000													55	49					0	0	1	0	0
RBM14	10432	broad.mit.edu	37	11	66384203	66384203	+	Silent	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr11:66384203C>T	ENST00000310137.4	+	1	151	c.12C>T	c.(10-12)ttC>ttT	p.F4F	RBM14_ENST00000443702.1_Silent_p.F4F|RBM14_ENST00000409738.4_Silent_p.F4F|RBM4_ENST00000503028.2_5'UTR|RBM14_ENST00000393979.3_Silent_p.F4F|RBM14-RBM4_ENST00000511114.1_3'UTR|RBM14-RBM4_ENST00000412278.2_Silent_p.F4F|RBM4_ENST00000514361.3_Silent_p.F4F|RBM14-RBM4_ENST00000500635.2_Silent_p.F4F|RBM14_ENST00000409372.1_Silent_p.F4F	NM_006328.3	NP_006319.1	Q96PK6	RBM14_HUMAN	RNA binding motif protein 14	4	RRM 1.				DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|histone deacetylation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus	mediator complex|ribonucleoprotein complex|transcription factor complex	ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|protein binding, bridging|RNA binding|RNA polymerase II transcription cofactor activity		RBM14/PACS1(2)	breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(3)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	17						TGAAGATATTCGTGGGCAACG	0.627000													13	11					0	0	1	0	0
CAMSAP2	23271	broad.mit.edu	37	1	200817643	200817643	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr1:200817643C>G	ENST00000358823.2	+	11	2016	c.1746C>G	c.(1744-1746)atC>atG	p.I582M	CAMSAP2_ENST00000413307.2_Missense_Mutation_p.I566M|CAMSAP2_ENST00000236925.4_Missense_Mutation_p.I593M	NM_203459.1	NP_982284.1	Q08AD1	CAMP2_HUMAN	calmodulin regulated spectrin-associated protein family, member 2	593						cytoplasm|microtubule	protein binding										ATTCAAATATCAAGTTAAATC	0.358000													22	88					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179425197	179425197	+	Silent	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr2:179425197G>A	ENST00000589042.1	-	326	85886	c.85662C>T	c.(85660-85662)ccC>ccT	p.P28554P	TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN_ENST00000359218.5_Silent_p.P19614P|TTN_ENST00000460472.2_Silent_p.P19489P|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000342992.6_Silent_p.P25986P|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000342175.6_Silent_p.P19681P|TTN_ENST00000591111.1_Silent_p.P26913P|TTN-AS1_ENST00000590807.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	26913	Ig-like 132.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCAAAGACGTGGGTGGACTTG	0.393000													16	8					0	0	1	0	0
ARHGAP29	9411	broad.mit.edu	37	1	94652079	94652079	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr1:94652079C>G	ENST00000260526.6	-	16	1938	c.1756G>C	c.(1756-1758)Gag>Cag	p.E586Q	ARHGAP29_ENST00000482481.1_5'UTR	NM_004815.3	NP_004806.3	Q52LW3	RHG29_HUMAN	Rho GTPase activating protein 29	586					Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			NS(1)|breast(5)|endometrium(6)|kidney(2)|large_intestine(9)|lung(19)|ovary(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		GAAGGTGGCTCTCTTTCATCT	0.388000													44	51					0	0	1	0	0
RNF157	114804	broad.mit.edu	37	17	74157697	74157697	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr17:74157697C>T	ENST00000269391.6	-	11	1116	c.984G>A	c.(982-984)atG>atA	p.M328I	RNF157_ENST00000319945.6_Missense_Mutation_p.M328I	NM_052916.2	NP_443148.1	Q96PX1	RN157_HUMAN	ring finger protein 157	328							zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(3)|lung(12)|ovary(2)|prostate(1)|skin(1)|stomach(2)|urinary_tract(1)	25			LUSC - Lung squamous cell carcinoma(166;0.187)			ATTTTTTCCTCATGGCTCGGA	0.507000													16	23					0	0	1	0	0
ESYT1	23344	broad.mit.edu	37	12	56536420	56536420	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr12:56536420C>T	ENST00000394048.5	+	26	3056	c.2792C>T	c.(2791-2793)tCc>tTc	p.S931F	ESYT1_ENST00000267113.4_Missense_Mutation_p.S941F|ESYT1_ENST00000541590.1_Missense_Mutation_p.S941F|ESYT1_ENST00000550878.1_3'UTR	NM_001184796.1|NM_015292.2	NP_001171725.1|NP_056107.1	Q9BSJ8	ESYT1_HUMAN	extended synaptotagmin-like protein 1	931	Poly-Ser.					integral to membrane				breast(2)|endometrium(2)|large_intestine(4)|lung(10)|ovary(5)|prostate(1)|skin(3)|urinary_tract(1)	28						AGCCACAGCTCCTCATCGCTG	0.587000													25	38					0	0	1	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43840442	43840442	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr12:43840442G>A	ENST00000389420.3	-	15	2152	c.2153C>T	c.(2152-2154)tCt>tTt	p.S718F	ADAMTS20_ENST00000553158.1_Missense_Mutation_p.S718F	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	718	Cys-rich.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		CTTGCATGAAGAGTTGTCCCC	0.373000													17	26					0	0	1	0	0
PEX13	5194	broad.mit.edu	37	2	61258581	61258581	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr2:61258581G>C	ENST00000295030.5	+	2	158	c.120G>C	c.(118-120)atG>atC	p.M40I	PEX13_ENST00000472678.1_3'UTR	NM_002618.3	NP_002609.1	Q92968	PEX13_HUMAN	peroxisomal biogenesis factor 13						cerebral cortex cell migration|fatty acid alpha-oxidation|locomotory behavior|microtubule-based peroxisome localization|neuron migration|protein import into peroxisome matrix, docking|suckling behavior	integral to peroxisomal membrane|membrane fraction	protein binding			endometrium(2)|large_intestine(2)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10			LUSC - Lung squamous cell carcinoma(5;2.05e-06)|Lung(5;3.13e-05)|Epithelial(17;0.114)			CTACTTTAATGACAAGACCTG	0.388000													32	26					0	0	1	0	0
POLR2A	5430	broad.mit.edu	37	17	7399872	7399872	+	Silent	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr17:7399872G>A	ENST00000322644.6	+	4	876	c.477G>A	c.(475-477)gaG>gaA	p.E159E	POLR2A_ENST00000572844.1_Silent_p.E159E	NM_000937.4	NP_000928	P24928	RPB1_HUMAN	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	159					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(17)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	50		Prostate(122;0.173)				GTGGGGAGGAGATGGACAACA	0.542000													38	42					0	0	1	0	0
ARID1B	57492	broad.mit.edu	37	6	157150430	157150430	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr6:157150430C>T	ENST00000346085.5	+	2	1613	c.1612C>T	c.(1612-1614)Cag>Tag	p.Q538*	ARID1B_ENST00000367148.1_Nonsense_Mutation_p.Q538*|ARID1B_ENST00000275248.4_Nonsense_Mutation_p.Q480*|ARID1B_ENST00000350026.5_Nonsense_Mutation_p.Q538*	NM_020732.3	NP_065783.3	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	538					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			NS(2)|breast(5)|central_nervous_system(4)|endometrium(12)|kidney(4)|large_intestine(11)|lung(30)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(3)	81		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		CCCTCATTCTCAGCCTCAGCA	0.552000													31	41					0	0	1	0	0
SLC9A7P1	121456	broad.mit.edu	37	12	98849730	98849730	+	RNA	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr12:98849730G>A	ENST00000554295.1	-	0	1193					NR_033801.1																						GAGCTTGTGTGATTCCACAGA	0.493000													53	73					0	0	1	0	0
ACTB	60	broad.mit.edu	37	7	5568242	5568242	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr7:5568242C>T	ENST00000331789.5	-	4	663	c.472G>A	c.(472-474)Ggg>Agg	p.G158R		NM_001101.3	NP_001092.1	P60709	ACTB_HUMAN	actin, beta	158					'de novo' posttranslational protein folding|adherens junction organization|axon guidance|blood coagulation|cell junction assembly|cellular component movement	cytoskeleton|cytosol|MLL5-L complex|NuA4 histone acetyltransferase complex|ribonucleoprotein complex	ATP binding|kinesin binding|nitric-oxide synthase binding|structural constituent of cytoskeleton			NS(1)|central_nervous_system(1)|large_intestine(2)|lung(2)|prostate(2)	8		Ovarian(82;0.0606)		UCEC - Uterine corpus endometrioid carcinoma (126;0.175)|OV - Ovarian serous cystadenocarcinoma(56;4.24e-37)		TGGGTGACCCCGTCACCGGAG	0.607000													49	32					0	0	1	0	0
KMT2A	4297	broad.mit.edu	37	11	118342400	118342400	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr11:118342400C>G	ENST00000534358.1	+	3	549	c.526C>G	c.(526-528)Cgt>Ggt	p.R176G	KMT2A_ENST00000389506.5_Missense_Mutation_p.R176G|KMT2A_ENST00000354520.4_Missense_Mutation_p.R176G	NM_001197104.1|NM_005933.3	NP_001184033.1|NP_005924.2			lysine (K)-specific methyltransferase 2A																		TCGAAAACCTCGTGGGAGACC	0.368000													24	12					0	0	1	0	0
FUT10	84750	broad.mit.edu	37	8	33230132	33230132	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr8:33230132G>A	ENST00000327671.5	-	5	2034	c.1403C>T	c.(1402-1404)tCa>tTa	p.S468L	FUT10_ENST00000524021.1_Missense_Mutation_p.S440L|FUT10_ENST00000518672.1_Missense_Mutation_p.S440L	NM_032664.3	NP_116053.3	Q6P4F1	FUT10_HUMAN	fucosyltransferase 10 (alpha (1,3) fucosyltransferase)	468					embryo development|fertilization|hemopoiesis|L-fucose catabolic process|nervous system development|protein folding|protein glycosylation|protein targeting|wound healing	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			cervix(1)|endometrium(1)|large_intestine(7)|liver(1)|lung(9)|ovary(1)|pancreas(1)|prostate(3)|stomach(3)|upper_aerodigestive_tract(2)	29				KIRC - Kidney renal clear cell carcinoma(67;0.129)|Kidney(114;0.154)		CTCTTGAGATGAAAAGTTTTG	0.413000													37	4					0	0	1	0	0
SH3PXD2B	285590	broad.mit.edu	37	5	171789745	171789745	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr5:171789745C>T	ENST00000311601.5	-	7	726	c.556G>A	c.(556-558)Gag>Aag	p.E186K	SH3PXD2B_ENST00000519643.1_Missense_Mutation_p.E186K	NM_001017995.2	NP_001017995.1	A1X283	SPD2B_HUMAN	SH3 and PX domains 2B	186	SH3 1.				adipose tissue development|bone development|cell communication|cell differentiation|eye development|heart development|podosome assembly	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-5-phosphate binding|SH2 domain binding			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(12)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	36	Renal(175;0.000159)|Lung NSC(126;0.011)|all_lung(126;0.0175)	Medulloblastoma(196;0.0207)|all_neural(177;0.0625)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CCACCTGACTCATTCTTCTCG	0.552000													16	29					0	0	1	0	0
TAF1B	9014	broad.mit.edu	37	2	10008411	10008411	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr2:10008411G>A	ENST00000263663.5	+	6	594	c.406G>A	c.(406-408)Gaa>Aaa	p.E136K	TAF1B_ENST00000396242.3_5'UTR|TAF1B_ENST00000402170.1_3'UTR	NM_005680.2	NP_005671	Q53T94	TAF1B_HUMAN	TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa	136					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|lung(4)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	14	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					ACAGGTATTAGAAGATAATCT	0.368000													26	17					0	0	1	0	0
ELF3	1999	broad.mit.edu	37	1	201981563	201981565	+	Splice_Site	DEL	TGG	TGG	-			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr1:201981563_201981565delTGG	ENST00000359651.3	+	3	3669_3670	c.477_478delTGG	c.(475-480)tttgga>ttga	p.159_160FG>L	ELF3_ENST00000495848.1_3'UTR|ELF3_ENST00000367283.3_Splice_Site_p.159_160FG>L|ELF3_ENST00000367284.5_Splice_Site_p.159_160FG>L|RP11-510N19.5_ENST00000504773.1_RNA			P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription factor, epithelial-specific )	159					epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(2)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	20						CAGGGCCCTTTGGTGAGAACCCG	0.581													18	18	---	---	---	---					
GREB1	9687	broad.mit.edu	37	2	11765359	11765360	+	Frame_Shift_Ins	INS	-	-	A			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr2:11765359_11765360insA	ENST00000381486.2	+	24	4527_4528	c.4227_4228insA	c.(4228-4230)tttfs	p.F1410fs	GREB1_ENST00000396123.1_Frame_Shift_Ins_p.F408fs|GREB1_ENST00000234142.5_Frame_Shift_Ins_p.F1410fs	NM_014668.3	NP_055483.2	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	1410						integral to membrane				breast(3)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)	30	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		AGAAGTTGCCCTTTGACTACAT	0.460													114	233	---	---	---	---					
CTD-2140G10.2	0	broad.mit.edu	37	11	22334218	22334219	+	RNA	INS	-	-	A	rs140765474	by1000genomes	TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr11:22334218_22334219insA	ENST00000528009.1	-	0	251																											ATCAGGAGGAGAAAATCTACAT	0.391													2	4	---	---	---	---					
LOC102723809	102723809	broad.mit.edu	37	14	65002600	65002601	+	RNA	INS	-	-	G	rs138724814	by1000genomes	TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr14:65002600_65002601insG	ENST00000554918.1	-	0	52																											GGGGGAGTCCAccccttttgct	0.594													2	4	---	---	---	---					
EP300	2033	broad.mit.edu	37	22	41554442	41554445	+	Frame_Shift_Del	DEL	TTGC	TTGC	-			TCGA-ZF-A9R4-01A-11D-A38G-08	TCGA-ZF-A9R4-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cebd9d9-bbac-4dee-86e2-d4eeb8c25ade	7ef6d222-c947-4e04-a965-80a6abb68393	g.chr22:41554442_41554445delTTGC	ENST00000263253.7	+	19	4747_4750	c.3528_3531delTTGC	c.(3526-3531)tgttgcfs	p.CC1176fs		NM_001429.3	NP_001420.2	Q09472	EP300_HUMAN	E1A binding protein p300	1176					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			NS(2)|breast(11)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(31)|kidney(5)|large_intestine(31)|liver(2)|lung(33)|ovary(2)|pancreas(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(16)	171						AGACACTGTGTTGCTACGGCAAAC	0.461			"""T,  N, F, Mis, O"""	"""MLL, RUNXBP2"""	"""colorectal, breast, pancreatic, AML, ALL, DLBCL"""				Rubinstein-Taybi syndrome				25	27	---	---	---	---