Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MYOT	9499	broad.mit.edu	37	5	137222946	137222946	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XF-AAMW-01A-11D-A42E-08	TCGA-XF-AAMW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e758da90-219b-4db9-ac2d-086847f5690d	29e158d6-4ad5-4863-8ea3-917a047024be	g.chr5:137222946C>T	ENST00000239926.4	+	10	1743	c.1369C>T	c.(1369-1371)Cga>Tga	p.R457*	RP11-381K20.2_ENST00000508281.2_RNA|MYOT_ENST00000515645.1_Nonsense_Mutation_p.R342*|RP11-381K20.2_ENST00000514616.1_RNA|MYOT_ENST00000421631.2_Nonsense_Mutation_p.R273*	NM_006790.2	NP_006781	Q9UBF9	MYOTI_HUMAN	myotilin	457	Necessary for interaction with ACTA1.|Necessary for interaction with FLNC.				muscle contraction	actin cytoskeleton|sarcolemma|sarcomere	actin binding|structural constituent of muscle			cervix(1)|kidney(2)|large_intestine(10)|lung(7)|ovary(1)|prostate(1)|urinary_tract(1)	23			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			GTTACGGGTTCGACCAACATT	0.393000													35	77					0	0	1	0	0
HMGB3	3149	broad.mit.edu	37	X	150156360	150156360	+	Silent	SNP	G	G	A			TCGA-XF-AAMW-01A-11D-A42E-08	TCGA-XF-AAMW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e758da90-219b-4db9-ac2d-086847f5690d	29e158d6-4ad5-4863-8ea3-917a047024be	g.chrX:150156360G>A	ENST00000325307.7	+	5	672	c.576G>A	c.(574-576)gaG>gaA	p.E192E	HMGB3_ENST00000448905.2_Silent_p.E192E	NM_005342.2	NP_005333.2	O15347	HMGB3_HUMAN	high mobility group box 3	192	Asp/Glu-rich (acidic).				DNA recombination|multicellular organismal development	chromosome|nucleus	DNA bending activity|double-stranded DNA binding	p.E192E(1)		endometrium(3)|large_intestine(2)|lung(2)|skin(1)	8	Acute lymphoblastic leukemia(192;6.56e-05)					aggaagaagaggaggaggagg	0.443000													4	121					0	0	1	0	0
ZNF8	7554	broad.mit.edu	37	19	58806614	58806614	+	Silent	SNP	T	T	C			TCGA-XF-AAMW-01A-11D-A42E-08	TCGA-XF-AAMW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e758da90-219b-4db9-ac2d-086847f5690d	29e158d6-4ad5-4863-8ea3-917a047024be	g.chr19:58806614T>C	ENST00000196548.5	+	4	1571	c.1440T>C	c.(1438-1440)tcT>tcC	p.S480S	AC010642.1_ENST00000591325.1_3'UTR|ZNF8_ENST00000608843.1_Silent_p.S480S			P17098	ZNF8_HUMAN	zinc finger protein 8	480					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(12)|ovary(1)|skin(1)	19		all_cancers(17;6.46e-05)|Lung NSC(17;0.0233)|all_neural(62;0.0381)|all_epithelial(17;0.0427)|all_lung(17;0.057)|Ovarian(87;0.17)|Colorectal(82;0.227)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.00619)		TTCAGAGCTCTCACCTCATCC	0.557000													65	131					0	0	1	0	0
LOC645752	645752	broad.mit.edu	37	15	78211548	78211548	+	RNA	SNP	T	T	C			TCGA-XF-AAMW-01A-11D-A42E-08	TCGA-XF-AAMW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e758da90-219b-4db9-ac2d-086847f5690d	29e158d6-4ad5-4863-8ea3-917a047024be	g.chr15:78211548T>C	ENST00000565869.1	+	0	111				RP11-114H24.2_ENST00000567226.1_RNA																							CCACCTGGGATTGGAGCTTTC	0.562000													5	119					0	0	1	0	0
LMOD2	442721	broad.mit.edu	37	7	123302912	123302912	+	Silent	SNP	T	T	C			TCGA-XF-AAMW-01A-11D-A42E-08	TCGA-XF-AAMW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e758da90-219b-4db9-ac2d-086847f5690d	29e158d6-4ad5-4863-8ea3-917a047024be	g.chr7:123302912T>C	ENST00000458573.2	+	2	1429	c.1272T>C	c.(1270-1272)ccT>ccC	p.P424P	LMOD2_ENST00000456238.2_Intron	NM_207163.1	NP_997046.1	Q6P5Q4	LMOD2_HUMAN	leiomodin 2 (cardiac)	424	Pro-rich.					cytoskeleton	actin binding|tropomyosin binding										ctcctcctcctccccctcctc	0.592000													3	4					0	0	1	0	0
SLC27A3	11000	broad.mit.edu	37	1	153751171	153751171	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMW-01A-11D-A42E-08	TCGA-XF-AAMW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e758da90-219b-4db9-ac2d-086847f5690d	29e158d6-4ad5-4863-8ea3-917a047024be	g.chr1:153751171G>A	ENST00000271857.2	+	7	2600	c.1840G>A	c.(1840-1842)Ggg>Agg	p.G614R	SLC27A3_ENST00000368661.3_Missense_Mutation_p.G533R|SLC27A3_ENST00000484014.1_3'UTR			Q5K4L6	S27A3_HUMAN	solute carrier family 27 (fatty acid transporter), member 3	533					fatty acid metabolic process	integral to membrane|mitochondrial membrane	ligase activity|nucleotide binding			NS(1)|endometrium(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)	14	all_lung(78;6.47e-32)|Lung NSC(65;2.52e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			AGGTGAGCCAGGGCTGCTGGT	0.637000													12	24					0	0	1	0	0
OR52W1	120787	broad.mit.edu	37	11	6220865	6220865	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMW-01A-11D-A42E-08	TCGA-XF-AAMW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e758da90-219b-4db9-ac2d-086847f5690d	29e158d6-4ad5-4863-8ea3-917a047024be	g.chr11:6220865C>T	ENST00000311352.2	+	1	490	c.412C>T	c.(412-414)Cct>Tct	p.P138S		NM_001005178.1	NP_001005178.1	Q6IF63	O52W1_HUMAN	olfactory receptor, family 52, subfamily W, member 1	138					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(6)	11		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;2.13e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ACTGCACTACCCTGTCCTGGT	0.542000													21	22					0	0	1	0	0
CNTNAP3B	728577	broad.mit.edu	37	9	43915893	43915893	+	Missense_Mutation	SNP	G	G	C	rs143747399	by1000genomes	TCGA-XF-AAMW-01A-11D-A42E-08	TCGA-XF-AAMW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e758da90-219b-4db9-ac2d-086847f5690d	29e158d6-4ad5-4863-8ea3-917a047024be	g.chr9:43915893G>C	ENST00000377564.3	+	23	4134	c.3741G>C	c.(3739-3741)atG>atC	p.M1247I		NM_001201380.1	NP_001188309.1	Q96NU0	CNT3B_HUMAN	contactin associated protein-like 3B	1247					cell adhesion|signal transduction	integral to membrane	receptor binding			central_nervous_system(1)|endometrium(2)|lung(3)|pancreas(1)|prostate(3)	10						CTGCTGTCATGGGAGGTAACA	0.433000													4	41					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195511870	195511870	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMW-01A-11D-A42E-08	TCGA-XF-AAMW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e758da90-219b-4db9-ac2d-086847f5690d	29e158d6-4ad5-4863-8ea3-917a047024be	g.chr3:195511870G>A	ENST00000463781.3	-	2	7040	c.6581C>T	c.(6580-6582)cCt>cTt	p.P2194L	MUC4_ENST00000349607.4_Intron|MUC4_ENST00000346145.4_Intron|MUC4_ENST00000475231.1_Missense_Mutation_p.P2194L	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	983					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GTCGGTGACAGGAAGAGGGGT	0.592000													3	9					0	0	1	0	0
LRRC37A6P	387646	broad.mit.edu	37	10	27538361	27538361	+	RNA	SNP	C	C	A			TCGA-XF-AAMW-01A-11D-A42E-08	TCGA-XF-AAMW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e758da90-219b-4db9-ac2d-086847f5690d	29e158d6-4ad5-4863-8ea3-917a047024be	g.chr10:27538361C>A	ENST00000574842.1	+	0	255				LRRC37A6P_ENST00000284414.4_RNA																							AAGGTTCAATCTCTGTTGTGG	0.522000													66	124					5.10508e-28	6.52976e-28	1	1	0
HRAS	3265	broad.mit.edu	37	11	534285	534285	+	Missense_Mutation	SNP	C	C	A	rs104894226		TCGA-XF-AAMW-01A-11D-A42E-08	TCGA-XF-AAMW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e758da90-219b-4db9-ac2d-086847f5690d	29e158d6-4ad5-4863-8ea3-917a047024be	g.chr11:534285C>A	ENST00000417302.1	-	2	225	c.38G>T	c.(37-39)gGt>gTt	p.G13V	HRAS_ENST00000311189.7_Missense_Mutation_p.G13V|HRAS_ENST00000397596.2_Missense_Mutation_p.G13V|HRAS_ENST00000397594.1_Missense_Mutation_p.G13V|HRAS_ENST00000451590.1_Missense_Mutation_p.G13V|HRAS_ENST00000468682.2_5'UTR	NM_176795.3	NP_789765.1	P01112	RASH_HUMAN	Harvey rat sarcoma viral oncogene homolog	13			G -> C (in FCSS).|G -> D (in FCSS).		activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.G13V(14)|p.G13D(10)|p.G12_G13insAG(1)		adrenal_gland(1)|bone(3)|breast(7)|cervix(23)|endometrium(4)|haematopoietic_and_lymphoid_tissue(12)|kidney(1)|large_intestine(2)|liver(1)|lung(16)|oesophagus(2)|penis(2)|pituitary(10)|prostate(31)|salivary_gland(24)|skin(184)|soft_tissue(38)|stomach(14)|testis(5)|thymus(1)|thyroid(173)|upper_aerodigestive_tract(122)|urinary_tract(225)	901		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	CTTGCCCACACCGCCGGCGCC	0.642000		6	Mis		"""infrequent sarcomas, rare other types"""	"""rhadomyosarcoma, ganglioneuroblastoma, bladder"""			Costello syndrome	HNSCC(11;0.0054)			11	19					4.68919e-08	5.37303e-08	1	1	0
AHNAK2	113146	broad.mit.edu	37	14	105405446	105405446	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMW-01A-11D-A42E-08	TCGA-XF-AAMW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e758da90-219b-4db9-ac2d-086847f5690d	29e158d6-4ad5-4863-8ea3-917a047024be	g.chr14:105405446G>A	ENST00000333244.5	-	7	16461	c.16342C>T	c.(16342-16344)Cct>Tct	p.P5448S	AHNAK2_ENST00000557457.1_Missense_Mutation_p.P446S	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	5448						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			AGGTCCACAGGCTGCTCCCCA	0.542000													4	12					0	0	1	0	0
LTBP2	4053	broad.mit.edu	37	14	74975940	74975940	+	Splice_Site	SNP	C	C	G			TCGA-XF-AAMW-01A-11D-A42E-08	TCGA-XF-AAMW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e758da90-219b-4db9-ac2d-086847f5690d	29e158d6-4ad5-4863-8ea3-917a047024be	g.chr14:74975940C>G	ENST00000261978.4	-	22	3790		c.e22+1		LTBP2_ENST00000556690.1_Splice_Site	NM_000428.2	NP_000419.1	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding protein 2						protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|liver(1)|lung(29)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		GAGGCTCATACCTTCACAGGA	0.647000													15	17					0	0	1	0	0
SLCO4A1	28231	broad.mit.edu	37	20	61292465	61292465	+	Silent	SNP	G	G	A			TCGA-XF-AAMW-01A-11D-A42E-08	TCGA-XF-AAMW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e758da90-219b-4db9-ac2d-086847f5690d	29e158d6-4ad5-4863-8ea3-917a047024be	g.chr20:61292465G>A	ENST00000217159.1	+	5	1264	c.1059G>A	c.(1057-1059)aaG>aaA	p.K353K	SLCO4A1_ENST00000370507.1_Silent_p.K353K	NM_016354.3	NP_057438.3	Q96BD0	SO4A1_HUMAN	solute carrier organic anion transporter family, member 4A1	353					sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			endometrium(6)|kidney(2)|large_intestine(1)|lung(7)|ovary(3)|prostate(2)	21	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;2.33e-06)			ACCAGTTGAAGGACAGCAGCC	0.642000													12	36					0	0	1	0	0
SALL1	6299	broad.mit.edu	37	16	51174119	51174119	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMW-01A-11D-A42E-08	TCGA-XF-AAMW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e758da90-219b-4db9-ac2d-086847f5690d	29e158d6-4ad5-4863-8ea3-917a047024be	g.chr16:51174119C>T	ENST00000440970.1	-	2	2154	c.1723G>A	c.(1723-1725)Gcc>Acc	p.A575T	SALL1_ENST00000566102.1_Intron|SALL1_ENST00000541611.1_Intron|SALL1_ENST00000251020.4_Missense_Mutation_p.A672T	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	672					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			GGAAACTTGGCCTTGAACTGC	0.587000													23	32					0	0	1	0	0
RP11-423O2.5	0	broad.mit.edu	37	1	142803543	142803543	+	RNA	SNP	C	C	T			TCGA-XF-AAMW-01A-11D-A42E-08	TCGA-XF-AAMW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e758da90-219b-4db9-ac2d-086847f5690d	29e158d6-4ad5-4863-8ea3-917a047024be	g.chr1:142803543C>T	ENST00000423385.1	-	0	1422																											TGTTGGAATTCCTGATGAATC	0.269000													4	140					0	0	1	0	0
OR8U1	219417	broad.mit.edu	37	11	56143123	56143123	+	Silent	SNP	G	G	A			TCGA-XF-AAMW-01A-11D-A42E-08	TCGA-XF-AAMW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e758da90-219b-4db9-ac2d-086847f5690d	29e158d6-4ad5-4863-8ea3-917a047024be	g.chr11:56143123G>A	ENST00000302270.1	+	1	24	c.24G>A	c.(22-24)caG>caA	p.Q8Q		NM_001005204.1	NP_001005204.1			olfactory receptor, family 8, subfamily U, member 1											NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(23)|ovary(4)|skin(1)|stomach(1)	39	Esophageal squamous(21;0.00448)					ATTGCACCCAGGCGACAGAGT	0.413000													9	13					0	0	1	0	0
ZFYVE26	23503	broad.mit.edu	37	14	68229479	68229479	+	Silent	SNP	C	C	T			TCGA-XF-AAMW-01A-11D-A42E-08	TCGA-XF-AAMW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e758da90-219b-4db9-ac2d-086847f5690d	29e158d6-4ad5-4863-8ea3-917a047024be	g.chr14:68229479C>T	ENST00000347230.4	-	33	6207	c.6069G>A	c.(6067-6069)gtG>gtA	p.V2023V	ZFYVE26_ENST00000555452.1_Silent_p.V2023V	NM_015346.3	NP_056161.2	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	2023					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(8)|lung(39)|ovary(12)|pancreas(1)|prostate(7)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	94				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		CCAAAGATGGCACGTGGCGAT	0.507000													14	31					0	0	1	0	0
USP38	84640	broad.mit.edu	37	4	144106956	144106956	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-AAMW-01A-11D-A42E-08	TCGA-XF-AAMW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e758da90-219b-4db9-ac2d-086847f5690d	29e158d6-4ad5-4863-8ea3-917a047024be	g.chr4:144106956C>A	ENST00000307017.4	+	1	859	c.353C>A	c.(352-354)cCg>cAg	p.P118Q	USP38_ENST00000510377.1_Missense_Mutation_p.P118Q	NM_032557.5	NP_115946.2	Q8NB14	UBP38_HUMAN	ubiquitin specific peptidase 38	118					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|urinary_tract(3)	33	all_hematologic(180;0.158)					ATGAGCTGTCCGTCGGTGCTG	0.572000													3	37					0.115264	0.117399	1	1	0
DCC	1630	broad.mit.edu	37	18	49867118	49867118	+	Translation_Start_Site	SNP	G	G	A			TCGA-XF-AAMW-01A-11D-A42E-08	TCGA-XF-AAMW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e758da90-219b-4db9-ac2d-086847f5690d	29e158d6-4ad5-4863-8ea3-917a047024be	g.chr18:49867118G>A	ENST00000442544.2	+	0	577					NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma						apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		gagtgCTGCCGCTGCCCGCGA	0.577000													9	42					0	0	1	0	0
EFEMP1	2202	broad.mit.edu	37	2	56094269	56094269	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMW-01A-11D-A42E-08	TCGA-XF-AAMW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e758da90-219b-4db9-ac2d-086847f5690d	29e158d6-4ad5-4863-8ea3-917a047024be	g.chr2:56094269C>T	ENST00000394555.2	-	11	1856	c.1421G>A	c.(1420-1422)gGg>gAg	p.G474E	EFEMP1_ENST00000355426.3_Missense_Mutation_p.G474E|EFEMP1_ENST00000394554.1_Missense_Mutation_p.G474E|EFEMP1_ENST00000424836.2_Missense_Mutation_p.G336E	NM_001039348.2|NM_001039349.2	NP_001034437.1|NP_001034438.1	Q12805	FBLN3_HUMAN	EGF containing fibulin-like extracellular matrix protein 1	474	Mediates interaction with TIMP3.				negative regulation of chondrocyte differentiation|peptidyl-tyrosine phosphorylation|regulation of transcription, DNA-dependent|visual perception	extracellular space|proteinaceous extracellular matrix	calcium ion binding|epidermal growth factor receptor activity|epidermal growth factor receptor binding|growth factor activity	p.G474E(1)		NS(1)|breast(2)|endometrium(4)|large_intestine(6)|lung(5)|ovary(5)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	28			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			GCGGAAGGTCCCTATACTGCT	0.438000													34	69					0	0	1	0	0
LOC101927060	101927060	broad.mit.edu	37	17	45128792	45128792	+	RNA	SNP	G	G	T	rs143713325	by1000genomes	TCGA-XF-AAMW-01A-11D-A42E-08	TCGA-XF-AAMW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e758da90-219b-4db9-ac2d-086847f5690d	29e158d6-4ad5-4863-8ea3-917a047024be	g.chr17:45128792G>T	ENST00000575173.1	-	0	418																											AATTCAGGTTGTCAGAATGCA	0.373000													4	77					0.00909568	0.00962043	1	1	0
DOK6	220164	broad.mit.edu	37	18	67345052	67345052	+	Silent	SNP	C	C	A			TCGA-XF-AAMW-01A-11D-A42E-08	TCGA-XF-AAMW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e758da90-219b-4db9-ac2d-086847f5690d	29e158d6-4ad5-4863-8ea3-917a047024be	g.chr18:67345052C>A	ENST00000382713.5	+	4	562	c.372C>A	c.(370-372)ccC>ccA	p.P124P	DOK6_ENST00000584435.1_3'UTR	NM_152721.5	NP_689934.2	Q6PKX4	DOK6_HUMAN	docking protein 6	124							insulin receptor binding			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	20		Colorectal(73;0.083)|Esophageal squamous(42;0.131)				TTGGGGAGCCCGACCTTCTGG	0.527000													15	29					2.32078e-09	2.77485e-09	1	1	0
BRCA1	672	broad.mit.edu	37	17	41245222	41245222	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-AAMW-01A-11D-A42E-08	TCGA-XF-AAMW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e758da90-219b-4db9-ac2d-086847f5690d	29e158d6-4ad5-4863-8ea3-917a047024be	g.chr17:41245222C>A	ENST00000309486.4	-	9	2465	c.1438G>T	c.(1438-1440)Gat>Tat	p.D480Y	BRCA1_ENST00000346315.3_Missense_Mutation_p.D776Y|BRCA1_ENST00000471181.2_Missense_Mutation_p.D776Y|BRCA1_ENST00000493795.1_Missense_Mutation_p.D729Y|BRCA1_ENST00000491747.2_Intron|BRCA1_ENST00000591849.1_Intron|BRCA1_ENST00000351666.3_Intron|BRCA1_ENST00000591534.1_Intron|BRCA1_ENST00000352993.3_Intron|BRCA1_ENST00000468300.1_Intron|BRCA1_ENST00000357654.3_Missense_Mutation_p.D776Y|BRCA1_ENST00000354071.3_Missense_Mutation_p.D776Y|BRCA1_ENST00000586385.1_Intron	NM_007297.3	NP_009228.2	P38398	BRCA1_HUMAN	breast cancer 1, early onset	776					androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(30)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(28)|ovary(36)|skin(2)|stomach(4)|urinary_tract(2)	120		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		GTGCCATAATCAGTACCAGGT	0.408000			"""D, Mis, N, F, S"""		ovarian	"""breast, ovarian"""		Homologous recombination	Hereditary Breast-Ovarian Cancer, BRCA1 type	TCGA Ovarian(2;0.000030)			5	261					1	1	1	1	0
PIP5K1C	23396	broad.mit.edu	37	19	3653479	3653479	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMW-01A-11D-A42E-08	TCGA-XF-AAMW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e758da90-219b-4db9-ac2d-086847f5690d	29e158d6-4ad5-4863-8ea3-917a047024be	g.chr19:3653479G>A	ENST00000335312.3	-	7	818	c.730C>T	c.(730-732)Cgc>Tgc	p.R244C	PIP5K1C_ENST00000539785.1_Missense_Mutation_p.R244C|PIP5K1C_ENST00000537021.1_Missense_Mutation_p.R244C|PIP5K1C_ENST00000587482.1_5'UTR|PIP5K1C_ENST00000589578.1_Missense_Mutation_p.R244C	NM_001195733.1|NM_012398.2	NP_001182662.1|NP_036530.1	O60331	PI51C_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type I, gamma	244	PIPK.				axon guidance	cytosol|plasma membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding			large_intestine(3)|ovary(1)|skin(3)|stomach(2)	9		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.95e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0026)|STAD - Stomach adenocarcinoma(1328;0.183)		TTGACCACGCGGGGCAGGATG	0.602000													14	36					0	0	1	0	0
MCCC2	64087	broad.mit.edu	37	5	70939667	70939667	+	Missense_Mutation	SNP	A	A	G			TCGA-XF-AAMW-01A-11D-A42E-08	TCGA-XF-AAMW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e758da90-219b-4db9-ac2d-086847f5690d	29e158d6-4ad5-4863-8ea3-917a047024be	g.chr5:70939667A>G	ENST00000340941.6	+	12	1223	c.1094A>G	c.(1093-1095)tAc>tGc	p.Y365C	MCCC2_ENST00000323375.8_Missense_Mutation_p.Y327C	NM_022132.4	NP_071415.1	Q9HCC0	MCCB_HUMAN	methylcrotonoyl-CoA carboxylase 2 (beta)	365	Acyl-CoA binding (Potential).|Carboxyltransferase.				leucine catabolic process	mitochondrial inner membrane|mitochondrial matrix	ATP binding|methylcrotonoyl-CoA carboxylase activity			endometrium(2)|kidney(15)|large_intestine(2)|lung(9)|ovary(1)|urinary_tract(1)	30		Lung NSC(167;0.000697)|Prostate(74;0.0107)|Ovarian(174;0.0175)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;2.04e-54)	Biotin(DB00121)	ATATTTGGGTACCCAGTAGGT	0.333000													35	81					0	0	1	0	0
HRAS	3265	broad.mit.edu	37	11	533276	533276	+	Splice_Site	SNP	C	C	A			TCGA-XF-AAMW-01A-11D-A42E-08	TCGA-XF-AAMW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e758da90-219b-4db9-ac2d-086847f5690d	29e158d6-4ad5-4863-8ea3-917a047024be	g.chr11:533276C>A	ENST00000417302.1	-	5	720		c.e5+1		HRAS_ENST00000311189.7_Intron|HRAS_ENST00000397596.2_Intron|HRAS_ENST00000397594.1_Splice_Site|HRAS_ENST00000451590.1_Intron	NM_176795.3	NP_789765.1	P01112	RASH_HUMAN	Harvey rat sarcoma viral oncogene homolog						activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding			adrenal_gland(1)|bone(3)|breast(7)|cervix(23)|endometrium(4)|haematopoietic_and_lymphoid_tissue(12)|kidney(1)|large_intestine(2)|liver(1)|lung(16)|oesophagus(2)|penis(2)|pituitary(10)|prostate(31)|salivary_gland(24)|skin(184)|soft_tissue(38)|stomach(14)|testis(5)|thymus(1)|thyroid(173)|upper_aerodigestive_tract(122)|urinary_tract(225)	901		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	GGGAGACTTACAGCGCGAGGG	0.726000		6	Mis		"""infrequent sarcomas, rare other types"""	"""rhadomyosarcoma, ganglioneuroblastoma, bladder"""			Costello syndrome	HNSCC(11;0.0054)			5	2					0.000602214	0.000662436	1	1	0
CASP9	842	broad.mit.edu	37	1	15844669	15844669	+	Silent	SNP	T	T	C			TCGA-XF-AAMW-01A-11D-A42E-08	TCGA-XF-AAMW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e758da90-219b-4db9-ac2d-086847f5690d	29e158d6-4ad5-4863-8ea3-917a047024be	g.chr1:15844669T>C	ENST00000546424.1	-	2	598	c.354A>G	c.(352-354)ccA>ccG	p.P118P	CASP9_ENST00000333868.5_Silent_p.P118P|CASP9_ENST00000375890.4_Silent_p.P35P|CASP9_ENST00000469637.1_5'UTR|CASP9_ENST00000348549.5_Silent_p.P118P			P55211	CASP9_HUMAN	caspase 9, apoptosis-related cysteine peptidase	118					activation of caspase activity by cytochrome c|induction of apoptosis by intracellular signals|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling	cytosol	cysteine-type endopeptidase activity|enzyme activator activity|protein binding			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)|stomach(1)	18		Breast(348;0.000207)|all_lung(284;0.000211)|Colorectal(325;0.000259)|Lung NSC(340;0.000269)|Renal(390;0.000518)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;8.49e-07)|COAD - Colon adenocarcinoma(227;4.36e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00013)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00763)|READ - Rectum adenocarcinoma(331;0.0655)		TGAGAACCTCTGGTTTGCGAA	0.512000													18	30					0	0	1	0	0
GCFC2	6936	broad.mit.edu	37	2	75891860	75891860	+	Missense_Mutation	SNP	T	T	G			TCGA-XF-AAMW-01A-11D-A42E-08	TCGA-XF-AAMW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e758da90-219b-4db9-ac2d-086847f5690d	29e158d6-4ad5-4863-8ea3-917a047024be	g.chr2:75891860T>G	ENST00000321027.3	-	17	2411	c.2278A>C	c.(2278-2280)Aat>Cat	p.N760H	MRPL19_ENST00000409374.1_Intron|GCFC2_ENST00000409857.3_Missense_Mutation_p.N722H|GCFC2_ENST00000541687.1_3'UTR|MRPL19_ENST00000358788.6_Intron	NM_001201334.1|NM_003203.4	NP_001188263.1|NP_003194.3	P16383	GCF_HUMAN	GC-rich sequence DNA-binding factor 2	760					negative regulation of transcription, DNA-dependent	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity										TCTGCTTGATTCAAAGCTTTT	0.294000													24	55					0	0	1	0	0
GAREM	64762	broad.mit.edu	37	18	29867319	29867319	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMW-01A-11D-A42E-08	TCGA-XF-AAMW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e758da90-219b-4db9-ac2d-086847f5690d	29e158d6-4ad5-4863-8ea3-917a047024be	g.chr18:29867319G>A	ENST00000399218.4	-	4	1296	c.1241C>T	c.(1240-1242)gCt>gTt	p.A414V	GAREM_ENST00000269209.6_Missense_Mutation_p.A414V	NM_001242409.1|NM_022751.2	NP_001229338.1|NP_073588.1			GRB2 associated, regulator of MAPK1																		AGGAAAGGGAGCCCAATCTCC	0.547000													23	42					0	0	1	0	0
HACE1	57531	broad.mit.edu	37	6	105177562	105177562	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMW-01A-11D-A42E-08	TCGA-XF-AAMW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e758da90-219b-4db9-ac2d-086847f5690d	29e158d6-4ad5-4863-8ea3-917a047024be	g.chr6:105177562C>T	ENST00000262903.4	-	24	2981	c.2705G>A	c.(2704-2706)gGc>gAc	p.G902D	HACE1_ENST00000369125.2_Missense_Mutation_p.G687D|HACE1_ENST00000517995.1_5'UTR	NM_020771.3	NP_065822.2	Q8IYU2	HACE1_HUMAN	HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1	902	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	endoplasmic reticulum	ubiquitin-protein ligase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(17)|ovary(5)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	44		all_cancers(87;6.89e-05)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0216)|Colorectal(196;0.202)		BRCA - Breast invasive adenocarcinoma(108;0.122)|Epithelial(106;0.204)		ACCATAGCTGCCACAATGTAG	0.383000													30	44					0	0	1	0	0
MMP14	4323	broad.mit.edu	37	14	23312527	23312527	+	Silent	SNP	C	C	T			TCGA-XF-AAMW-01A-11D-A42E-08	TCGA-XF-AAMW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e758da90-219b-4db9-ac2d-086847f5690d	29e158d6-4ad5-4863-8ea3-917a047024be	g.chr14:23312527C>T	ENST00000311852.6	+	5	1011	c.750C>T	c.(748-750)tcC>tcT	p.S250S	MMP14_ENST00000548162.1_3'UTR	NM_004995.2	NP_004986.1	P50281	MMP14_HUMAN	matrix metallopeptidase 14 (membrane-inserted)	250						extracellular matrix|integral to plasma membrane|melanosome	calcium ion binding|metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(5)|prostate(1)|skin(2)|urinary_tract(1)	20	all_cancers(95;9.47e-05)			GBM - Glioblastoma multiforme(265;0.00551)		TCGAGCATTCCAGTGACCCCT	0.582000													19	39					0	0	1	0	0
HDAC11	79885	broad.mit.edu	37	3	13522848	13522848	+	Missense_Mutation	SNP	T	T	A			TCGA-XF-AAMW-01A-11D-A42E-08	TCGA-XF-AAMW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e758da90-219b-4db9-ac2d-086847f5690d	29e158d6-4ad5-4863-8ea3-917a047024be	g.chr3:13522848T>A	ENST00000295757.3	+	2	288	c.105T>A	c.(103-105)caT>caA	p.H35Q	HDAC11_ENST00000402259.1_Missense_Mutation_p.H35Q|HDAC11_ENST00000437379.2_Missense_Mutation_p.H7Q|HDAC11_ENST00000404040.1_Missense_Mutation_p.H35Q|HDAC11_ENST00000405025.1_Missense_Mutation_p.H7Q|HDAC11_ENST00000404548.1_Missense_Mutation_p.H35Q|HDAC11_ENST00000522202.1_Missense_Mutation_p.H7Q|HDAC11_ENST00000446613.2_5'UTR|HDAC11_ENST00000433119.1_Missense_Mutation_p.H7Q|HDAC11_ENST00000402271.1_Missense_Mutation_p.H35Q	NM_024827.3	NP_079103.2	Q96DB2	HDA11_HUMAN	histone deacetylase 11	35	Histone deacetylase.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	histone deacetylase complex|plasma membrane	histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|transcription factor binding			breast(1)|endometrium(2)|large_intestine(1)|lung(2)|ovary(4)|prostate(3)	13						AGAAGCTGCATCCCTTTGATG	0.537000													5	31					0	0	1	0	0
PGM2	55276	broad.mit.edu	37	4	37841802	37841802	+	Missense_Mutation	SNP	A	A	G			TCGA-XF-AAMW-01A-11D-A42E-08	TCGA-XF-AAMW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e758da90-219b-4db9-ac2d-086847f5690d	29e158d6-4ad5-4863-8ea3-917a047024be	g.chr4:37841802A>G	ENST00000381967.4	+	6	740	c.640A>G	c.(640-642)Agc>Ggc	p.S214G	PGM2_ENST00000537241.1_Missense_Mutation_p.S54G|PGM2_ENST00000544359.1_Missense_Mutation_p.S75G	NM_018290.3	NP_060760.2	Q96G03	PGM2_HUMAN	phosphoglucomutase 2	214					glucose 1-phosphate metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	magnesium ion binding|phosphoglucomutase activity|phosphopentomutase activity			breast(1)|kidney(2)|large_intestine(3)|lung(10)|ovary(2)|urinary_tract(1)	19						TTTAATTGATAGCAGTCCACT	0.403000													26	71					0	0	1	0	0
PTPN3	5774	broad.mit.edu	37	9	112200395	112200395	+	Splice_Site	SNP	T	T	G			TCGA-XF-AAMW-01A-11D-A42E-08	TCGA-XF-AAMW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e758da90-219b-4db9-ac2d-086847f5690d	29e158d6-4ad5-4863-8ea3-917a047024be	g.chr9:112200395T>G	ENST00000412145.1	-	3	2746	c.193A>C	c.(193-195)Agt>Cgt	p.S65R	PTPN3_ENST00000374541.2_Splice_Site_p.S196R|PTPN3_ENST00000262539.3_Splice_Site_p.S87R|PTPN3_ENST00000446349.1_Splice_Site_p.S65R	NM_001145369.1|NM_001145371.1	NP_001138841.1|NP_001138843.1	P26045	PTN3_HUMAN	protein tyrosine phosphatase, non-receptor type 3	196	FERM.				negative regulation of membrane protein ectodomain proteolysis|negative regulation of mitotic cell cycle	cytoplasm|cytoskeleton|internal side of plasma membrane	ATPase binding|cytoskeletal protein binding|phosphotyrosine binding|protein tyrosine phosphatase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(14)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	41						CCCCCTCACCTGTGCTGCTCA	0.453000													7	44					0	0	1	0	0
THBS2	7058	broad.mit.edu	37	6	169641993	169641993	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-AAMW-01A-11D-A42E-08	TCGA-XF-AAMW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e758da90-219b-4db9-ac2d-086847f5690d	29e158d6-4ad5-4863-8ea3-917a047024be	g.chr6:169641993G>T	ENST00000366787.3	-	6	1004	c.755C>A	c.(754-756)aCc>aAc	p.T252N		NM_003247.2	NP_003238.2	P35442	TSP2_HUMAN	thrombospondin 2	252					cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			NS(3)|biliary_tract(1)|endometrium(8)|kidney(3)|large_intestine(23)|liver(1)|lung(56)|ovary(6)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	111		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		CACGTACTCGGTGGTGACATG	0.637000													21	23					5.35356e-11	6.54324e-11	1	1	0
WDR91	29062	broad.mit.edu	37	7	134878389	134878389	+	Silent	SNP	G	G	C			TCGA-XF-AAMW-01A-11D-A42E-08	TCGA-XF-AAMW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e758da90-219b-4db9-ac2d-086847f5690d	29e158d6-4ad5-4863-8ea3-917a047024be	g.chr7:134878389G>C	ENST00000354475.4	-	10	1462	c.1431C>G	c.(1429-1431)ctC>ctG	p.L477L	WDR91_ENST00000344400.5_Silent_p.L477L|WDR91_ENST00000423565.1_Silent_p.L442L	NM_014149.3	NP_054868.3	A4D1P6	WDR91_HUMAN	WD repeat domain 91	477										breast(3)|endometrium(2)|kidney(2)|large_intestine(12)|lung(14)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	40						CCGTGTCATAGAGACGCACTG	0.552000													6	52					0	0	1	0	0
GOLGA4	2803	broad.mit.edu	37	3	37396630	37396630	+	Silent	SNP	T	T	C			TCGA-XF-AAMW-01A-11D-A42E-08	TCGA-XF-AAMW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e758da90-219b-4db9-ac2d-086847f5690d	29e158d6-4ad5-4863-8ea3-917a047024be	g.chr3:37396630T>C	ENST00000361924.2	+	22	6989	c.6615T>C	c.(6613-6615)ccT>ccC	p.P2205P	GOLGA4_ENST00000356847.4_Silent_p.P2220P|GOLGA4_ENST00000444882.1_Intron	NM_002078.4	NP_002069.2	Q13439	GOGA4_HUMAN	golgin A4	2205	GRIP.				Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding			NS(2)|breast(3)|central_nervous_system(3)|endometrium(6)|kidney(2)|large_intestine(17)|liver(2)|lung(16)|ovary(4)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	65						TGAAGTTCCCTGATGATCAGA	0.393000													18	59					0	0	1	0	0
DMBX1	127343	broad.mit.edu	37	1	46976759	46976759	+	Silent	SNP	C	C	T			TCGA-XF-AAMW-01A-11D-A42E-08	TCGA-XF-AAMW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e758da90-219b-4db9-ac2d-086847f5690d	29e158d6-4ad5-4863-8ea3-917a047024be	g.chr1:46976759C>T	ENST00000371956.4	+	3	516	c.501C>T	c.(499-501)ccC>ccT	p.P167P	DMBX1_ENST00000360032.3_Silent_p.P162P	NM_147192.2	NP_671725.1	Q8NFW5	DMBX1_HUMAN	diencephalon/mesencephalon homeobox 1	167					brain development|developmental growth|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(3)|lung(6)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	Acute lymphoblastic leukemia(166;0.155)					CTGAGCAGCCCCCACGTCTGC	0.647000													19	45					0	0	1	0	0
FSTL3	10272	broad.mit.edu	37	19	677792	677792	+	Splice_Site	SNP	G	G	A			TCGA-XF-AAMW-01A-11D-A42E-08	TCGA-XF-AAMW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e758da90-219b-4db9-ac2d-086847f5690d	29e158d6-4ad5-4863-8ea3-917a047024be	g.chr19:677792G>A	ENST00000166139.4	+	2	136	c.104G>A	c.(103-105)gGt>gAt	p.G35D		NM_005860.2	NP_005851.1	O95633	FSTL3_HUMAN	follistatin-like 3 (secreted glycoprotein)	35					hemopoietic progenitor cell differentiation|negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of osteoclast differentiation|ossification|positive regulation of cell-cell adhesion|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	extracellular space|nucleus	activin binding|fibronectin binding						all_epithelial(18;2.19e-21)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGGCCCGCAGGTGGTGTTTGC	0.662000			T	CCND1	B-CLL								7	14					0	0	1	0	0
GGTLC1	92086	broad.mit.edu	37	20	23965905	23965905	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-AAMW-01A-11D-A42E-08	TCGA-XF-AAMW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e758da90-219b-4db9-ac2d-086847f5690d	29e158d6-4ad5-4863-8ea3-917a047024be	g.chr20:23965905C>A	ENST00000335694.4	-	6	830	c.626G>T	c.(625-627)gGc>gTc	p.G209V	GGTLC1_ENST00000286890.4_Missense_Mutation_p.G209V|GGTLC1_ENST00000278765.4_Missense_Mutation_p.G209V	NM_178311.2	NP_842563.1	Q9BX51	GGTL1_HUMAN	gamma-glutamyltransferase light chain 1	209							gamma-glutamyltransferase activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	15						AGCTGCCCAGCCACCAGCCAT	0.597000													7	31					2.7689e-08	3.2402e-08	1	1	0
SBK2	646643	broad.mit.edu	37	19	56041201	56041201	+	Missense_Mutation	SNP	T	T	C			TCGA-XF-AAMW-01A-11D-A42E-08	TCGA-XF-AAMW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e758da90-219b-4db9-ac2d-086847f5690d	29e158d6-4ad5-4863-8ea3-917a047024be	g.chr19:56041201T>C	ENST00000413299.1	-	4	983	c.946A>G	c.(946-948)Agc>Ggc	p.S316G	SBK2_ENST00000344158.3_Missense_Mutation_p.S316G	NM_001101401.2	NP_001094871.2	P0C263	SBK2_HUMAN	SH3 domain binding kinase family, member 2	316	Protein kinase.						ATP binding|protein serine/threonine kinase activity			endometrium(1)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	9						ATCACAGCGCTCCTCCTTCGG	0.756000													5	13					0	0	1	0	0
TAAR1	134864	broad.mit.edu	37	6	132966320	132966320	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAMW-01A-11D-A42E-08	TCGA-XF-AAMW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e758da90-219b-4db9-ac2d-086847f5690d	29e158d6-4ad5-4863-8ea3-917a047024be	g.chr6:132966320G>C	ENST00000275216.1	-	1	822	c.823C>G	c.(823-825)Cct>Gct	p.P275A		NM_138327.1	NP_612200.1	Q96RJ0	TAAR1_HUMAN	trace amine associated receptor 1	275						plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)	18	Breast(56;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00616)|GBM - Glioblastoma multiforme(226;0.0154)	Amphetamine(DB00182)	TGAAGAAAAGGGTCCATGACT	0.368000													17	49					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7576891	7576891	+	Nonsense_Mutation	SNP	T	T	A			TCGA-XF-AAMW-01A-11D-A42E-08	TCGA-XF-AAMW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e758da90-219b-4db9-ac2d-086847f5690d	29e158d6-4ad5-4863-8ea3-917a047024be	g.chr17:7576891T>A	ENST00000420246.2	-	9	1087	c.955A>T	c.(955-957)Aag>Tag	p.K319*	TP53_ENST00000455263.2_Nonsense_Mutation_p.K319*|TP53_ENST00000413465.2_Intron|TP53_ENST00000445888.2_Nonsense_Mutation_p.K319*|TP53_ENST00000269305.4_Nonsense_Mutation_p.K319*|TP53_ENST00000359597.4_Nonsense_Mutation_p.K319*	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	319	Interaction with CARM1.|Interaction with HIPK1 (By similarity).|Interaction with HIPK2.		K -> E (in sporadic cancers; somatic mutation).|K -> N (in a sporadic cancer; somatic mutation).|K -> R (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(8)|p.K319*(8)|p.P318fs*15(2)|p.K319fs*19(2)|p.K319E(2)|p.P318fs*21(1)|p.S315fs*22(1)|p.?(1)|p.S314fs*25(1)|p.L308fs*15(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGTTTCTTCTTTGGCTGGGGA	0.468000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			22	13					0	0	1	0	0
ATG7	10533	broad.mit.edu	37	3	11468324	11468324	+	Frame_Shift_Del	DEL	T	T	-			TCGA-XF-AAMW-01A-11D-A42E-08	TCGA-XF-AAMW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e758da90-219b-4db9-ac2d-086847f5690d	29e158d6-4ad5-4863-8ea3-917a047024be	g.chr3:11468324delT	ENST00000354449.3	+	18	2028	c.2003delT	c.(2002-2004)gtgfs	p.V668fs	ATG7_ENST00000354956.5_Frame_Shift_Del_p.V641fs|ATG7_ENST00000446450.2_Intron	NM_006395.2	NP_006386.1	O95352	ATG7_HUMAN	autophagy related 7	668					autophagy|cellular membrane fusion|positive regulation of protein modification process|protein lipidation|protein transport	cytoplasm	APG12 activating enzyme activity|protein homodimerization activity|ubiquitin activating enzyme activity			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(14)|prostate(1)|skin(2)|urinary_tract(1)	34						CTAGCCAAGGTGTTTAATTCT	0.353													14	38	---	---	---	---					
INTS4P2	644619	broad.mit.edu	37	7	65150824	65150825	+	RNA	INS	-	-	G			TCGA-XF-AAMW-01A-11D-A42E-08	TCGA-XF-AAMW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e758da90-219b-4db9-ac2d-086847f5690d	29e158d6-4ad5-4863-8ea3-917a047024be	g.chr7:65150824_65150825insG	ENST00000430126.2	+	0	757																											TCACCCCCCCCCCCGTTAAAAT	0.470													2	4	---	---	---	---					
ADAMTSL1	92949	broad.mit.edu	37	9	18908504	18908504	+	Frame_Shift_Del	DEL	C	C	-			TCGA-XF-AAMW-01A-11D-A42E-08	TCGA-XF-AAMW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e758da90-219b-4db9-ac2d-086847f5690d	29e158d6-4ad5-4863-8ea3-917a047024be	g.chr9:18908504delC	ENST00000380548.4	+	29	5586	c.5247delC	c.(5245-5247)agcfs	p.S1749fs	ADAMTSL1_ENST00000380545.5_Frame_Shift_Del_p.S450fs	NM_001040272.5	NP_001035362.3	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1	1749	PLAC.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		GCCAACTCAGCCAGTTTAAAT	0.547													2	4	---	---	---	---					
RP11-526P5.2	0	broad.mit.edu	37	10	2561172	2561173	+	RNA	INS	-	-	C	rs34717268	by1000genomes	TCGA-XF-AAMW-01A-11D-A42E-08	TCGA-XF-AAMW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e758da90-219b-4db9-ac2d-086847f5690d	29e158d6-4ad5-4863-8ea3-917a047024be	g.chr10:2561172_2561173insC	ENST00000438753.1	+	0	207																											aagaagaagGGGGGGGGAGGAG	0.381													3	4	---	---	---	---					
PDXDC2P	283970	broad.mit.edu	37	16	70030143	70030143	+	RNA	DEL	A	A	-			TCGA-XF-AAMW-01A-11D-A42E-08	TCGA-XF-AAMW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e758da90-219b-4db9-ac2d-086847f5690d	29e158d6-4ad5-4863-8ea3-917a047024be	g.chr16:70030143delA	ENST00000531894.1	-	0	1647					NR_003610.1																						TTAGACAATTAAAAAAAAAAA	0.423													2	4	---	---	---	---					
RP11-252A24.2	0	broad.mit.edu	37	16	74372914	74372914	+	RNA	DEL	G	G	-	rs67181940		TCGA-XF-AAMW-01A-11D-A42E-08	TCGA-XF-AAMW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e758da90-219b-4db9-ac2d-086847f5690d	29e158d6-4ad5-4863-8ea3-917a047024be	g.chr16:74372914delG	ENST00000429810.2	-	0	1404																											AACGTAGtttgtttttttttt	0.433													2	4	---	---	---	---					
ABR	29	broad.mit.edu	37	17	909374	909374	+	Frame_Shift_Del	DEL	G	G	-			TCGA-XF-AAMW-01A-11D-A42E-08	TCGA-XF-AAMW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e758da90-219b-4db9-ac2d-086847f5690d	29e158d6-4ad5-4863-8ea3-917a047024be	g.chr17:909374delG	ENST00000544583.2	-	23	2987	c.2388delC	c.(2386-2388)cccfs	p.P796fs	ABR_ENST00000574437.1_Frame_Shift_Del_p.P796fs|ABR_ENST00000572441.1_Intron|ABR_ENST00000543210.2_Frame_Shift_Del_p.P293fs|ABR_ENST00000536794.2_Frame_Shift_Del_p.P624fs|ABR_ENST00000291107.2_Frame_Shift_Del_p.P805fs|ABR_ENST00000302538.5_Frame_Shift_Del_p.P842fs	NM_001159746.2	NP_001153218.1	Q12979	ABR_HUMAN	active BCR-related	842	Rho-GAP.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity	p.I843fs*>18(1)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39				UCEC - Uterine corpus endometrioid carcinoma (25;0.0228)		CGAAGGAAATGGGGGGGTGCT	0.642													3	3	---	---	---	---					
TP53I13	90313	broad.mit.edu	37	17	27899699	27899699	+	Frame_Shift_Del	DEL	C	C	-			TCGA-XF-AAMW-01A-11D-A42E-08	TCGA-XF-AAMW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e758da90-219b-4db9-ac2d-086847f5690d	29e158d6-4ad5-4863-8ea3-917a047024be	g.chr17:27899699delC	ENST00000301057.7	+	6	1168	c.1053delC	c.(1051-1053)agcfs	p.S351fs	RP11-68I3.2_ENST00000581474.1_RNA	NM_138349.2	NP_612358.3	Q8NBR0	P5I13_HUMAN	tumor protein p53 inducible protein 13	351						cytoplasm|integral to membrane|plasma membrane				NS(1)|kidney(1)|lung(1)|urinary_tract(1)	4				READ - Rectum adenocarcinoma(3;0.236)		CAGCGGACAGCCAGGACACAG	0.701													2	4	---	---	---	---					
MYT1	4661	broad.mit.edu	37	20	62839333	62839335	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-XF-AAMW-01A-11D-A42E-08	TCGA-XF-AAMW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e758da90-219b-4db9-ac2d-086847f5690d	29e158d6-4ad5-4863-8ea3-917a047024be	g.chr20:62839333_62839335delGAG	ENST00000536311.1	+	7	1148_1150	c.784_786delGAG	c.(784-786)gagdel	p.E273del	MYT1_ENST00000328439.1_In_Frame_Del_p.E273del|MYT1_ENST00000360149.4_Intron			Q01538	MYT1_HUMAN	myelin transcription factor 1	273	Glu-rich.				cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(12)|liver(1)|lung(17)|ovary(5)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					agaggaggacgaggaggaggagg	0.596													2	4	---	---	---	---					
CDC42EP1	11135	broad.mit.edu	37	22	37964409	37964429	+	In_Frame_Del	DEL	CAGCGCCTGCTGCAAACCCCT	CAGCGCCTGCTGCAAACCCCT	-	rs13056859	by1000genomes	TCGA-XF-AAMW-01A-11D-A42E-08	TCGA-XF-AAMW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e758da90-219b-4db9-ac2d-086847f5690d	29e158d6-4ad5-4863-8ea3-917a047024be	g.chr22:37964409_37964429delCAGCGCCTGCTGCAAACCCCT	ENST00000249014.4	+	3	1178_1198	c.758_778delCAGCGCCTGCTGCAAACCCCT	c.(757-780)ccagcgcctgctgcaaacccctca>cca	p.APAANPS254del		NM_152243.2	NP_689449.1	Q00587	BORG5_HUMAN	CDC42 effector protein (Rho GTPase binding) 1	254	8 X 7 AA tandem repeats of [PT]-[AT]-A- [ENT]-[PT]-[PTS]-[AG].				positive regulation of pseudopodium assembly|regulation of cell shape	actin cytoskeleton|endomembrane system|Golgi apparatus|plasma membrane	protein binding	p.N258_A264delNPSAPAA(3)		endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(4)|prostate(5)	15	Melanoma(58;0.0574)					GCAAACCCCCCAGCGCCTGCTGCAAACCCCTCAGCACCTGC	0.665													7	1	---	---	---	---