Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RWDD2A	112611	broad.mit.edu	37	6	83905938	83905938	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr6:83905938G>C	ENST00000369724.4	+	3	1031	c.826G>C	c.(826-828)Gag>Cag	p.E276Q	RWDD2A_ENST00000539997.1_Missense_Mutation_p.E222Q	NM_033411.3	NP_219479.2	Q9UIY3	RWD2A_HUMAN	RWD domain containing 2A	276										cervix(1)|large_intestine(1)|lung(1)|prostate(1)|skin(1)	5		all_cancers(76;2.38e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00217)		BRCA - Breast invasive adenocarcinoma(397;0.045)		GCACAAAAGTGAGCATGTTTT	0.363000													23	55					0	0	1	0	0
CSNK2A1	1457	broad.mit.edu	37	20	472991	472991	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr20:472991C>T	ENST00000217244.3	-	9	903	c.528G>A	c.(526-528)tgG>tgA	p.W176*	CSNK2A1_ENST00000400227.3_Nonsense_Mutation_p.W176*|CSNK2A1_ENST00000349736.5_Nonsense_Mutation_p.W176*|CSNK2A1_ENST00000400217.2_Nonsense_Mutation_p.W40*	NM_177559.2	NP_808227.1	P68400	CSK21_HUMAN	casein kinase 2, alpha 1 polypeptide	176	Protein kinase.				axon guidance|Wnt receptor signaling pathway	cytosol|NuRD complex|plasma membrane|Sin3 complex	ATP binding|protein N-terminus binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)|urinary_tract(1)	17		Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.0969)			CAGCCAAACCCCAGTCTATTA	0.393000													11	43					0	0	1	0	0
DCC	1630	broad.mit.edu	37	18	50985651	50985651	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr18:50985651C>A	ENST00000442544.2	+	24	4058	c.3442C>A	c.(3442-3444)Ctc>Atc	p.L1148I	DCC_ENST00000581580.1_Missense_Mutation_p.L783I	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	1148					apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		CCAGAAGGACCTCCGACCCCC	0.493000													70	27					1.49552e-23	1.63217e-23	1	1	0
MYLK3	91807	broad.mit.edu	37	16	46744549	46744549	+	Splice_Site	SNP	C	C	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr16:46744549C>T	ENST00000394809.4	-	11	2382	c.2267G>A	c.(2266-2268)aGc>aAc	p.S756N	MYLK3_ENST00000562104.1_5'UTR|MYLK3_ENST00000536476.1_Splice_Site_p.S415N	NM_182493.2	NP_872299.2	Q32MK0	MYLK3_HUMAN	myosin light chain kinase 3	756	Protein kinase.				cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(7)|lung(11)|ovary(3)|prostate(3)|skin(5)|stomach(3)	37		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				TGAAAGGTACCTCTTCTCTTT	0.532000													43	101					0	0	1	0	0
ADAR	103	broad.mit.edu	37	1	154562706	154562706	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr1:154562706C>G	ENST00000368474.4	-	7	2649	c.2450G>C	c.(2449-2451)aGa>aCa	p.R817T	ADAR_ENST00000292205.5_Missense_Mutation_p.R860T|ADAR_ENST00000368471.3_Missense_Mutation_p.R522T	NM_001111.4|NM_015840.3|NM_015841.3	NP_001102|NP_056655.2|NP_056656.2	P55265	DSRAD_HUMAN	adenosine deaminase, RNA-specific	817					adenosine to inosine editing|gene silencing by RNA|mRNA modification|mRNA processing|type I interferon-mediated signaling pathway	cytoplasm|nucleolus|nucleoplasm	DNA binding|double-stranded RNA adenosine deaminase activity|metal ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|lung(20)|ovary(4)|prostate(2)|skin(2)	51	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.0997)		LUSC - Lung squamous cell carcinoma(543;0.185)	Colorectal(1306;0.115)		GAGCATAGTTCTTCTGAGACT	0.552000													33	60					0	0	1	0	0
RPH3A	22895	broad.mit.edu	37	12	113325677	113325677	+	Silent	SNP	G	G	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr12:113325677G>A	ENST00000389385.4	+	17	2009	c.1512G>A	c.(1510-1512)ctG>ctA	p.L504L	RPH3A_ENST00000420983.2_Silent_p.L504L|RPH3A_ENST00000447659.2_Silent_p.L455L|RPH3A_ENST00000548866.1_Silent_p.L455L|RPH3A_ENST00000549913.2_3'UTR|RPH3A_ENST00000543106.2_Silent_p.L504L|RPH3A_ENST00000551052.1_Silent_p.L500L|RPH3A_ENST00000415485.3_Silent_p.L504L	NM_001143854.1|NM_014954.3	NP_001137326.1|NP_055769.2	Q9Y2J0	RP3A_HUMAN	rabphilin 3A homolog (mouse)	504					intracellular protein transport	cell junction|synaptic vesicle	Rab GTPase binding|transporter activity|zinc ion binding			breast(1)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(16)|ovary(3)|prostate(4)|skin(6)|urinary_tract(1)	47				BRCA - Breast invasive adenocarcinoma(302;0.00453)		TCAAGAAACTGAAGCCCAACC	0.502000													63	198					0	0	1	0	0
GRM2	2912	broad.mit.edu	37	3	51743211	51743211	+	Missense_Mutation	SNP	G	G	A	rs144180122	by1000genomes	TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr3:51743211G>A	ENST00000395052.3	+	2	446	c.212G>A	c.(211-213)cGc>cAc	p.R71H	GRM2_ENST00000475478.1_Intron|GRM2_ENST00000442933.2_Missense_Mutation_p.R71H	NM_000839.3	NP_000830.2	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2	71					synaptic transmission	integral to plasma membrane				breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(1)|lung(11)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	GCACTGGACCGCATCAACCGT	0.632000													52	202					0	0	1	0	0
LDHD	197257	broad.mit.edu	37	16	75149487	75149487	+	Silent	SNP	C	C	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr16:75149487C>T	ENST00000300051.4	-	2	190	c.144G>A	c.(142-144)gcG>gcA	p.A48A	LDHD_ENST00000450168.2_Silent_p.A48A	NM_153486.3	NP_705690.2	Q86WU2	LDHD_HUMAN	lactate dehydrogenase D	48							D-lactate dehydrogenase (cytochrome) activity|flavin adenine dinucleotide binding|protein binding			endometrium(1)|large_intestine(2)|lung(12)|upper_aerodigestive_tract(1)	16						CTCGGACCACCGCGGCAGTGG	0.652000													7	38					0	0	1	0	0
ZFP37	7539	broad.mit.edu	37	9	115806346	115806346	+	Silent	SNP	C	C	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr9:115806346C>T	ENST00000374227.3	-	4	579	c.552G>A	c.(550-552)ttG>ttA	p.L184L	ZFP37_ENST00000553380.1_Silent_p.L199L|ZFP37_ENST00000555206.1_Silent_p.L185L	NM_001282515.1|NM_001282518.1	NP_001269444.1|NP_001269447.1	Q9Y6Q3	ZFP37_HUMAN	ZFP37 zinc finger protein	184						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	38						AATTCTGTTTCAAAATTTTTC	0.333000													39	63					0	0	1	0	0
PNISR	25957	broad.mit.edu	37	6	99848724	99848724	+	Missense_Mutation	SNP	A	A	G			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr6:99848724A>G	ENST00000369239.5	-	12	2314	c.2110T>C	c.(2110-2112)Ttc>Ctc	p.F704L	PNISR_ENST00000438806.1_Missense_Mutation_p.F704L	NM_032870.2	NP_116259.2	Q8TF01	PNISR_HUMAN	PNN-interacting serine/arginine-rich protein	704						nuclear speck				breast(2)|cervix(1)|endometrium(3)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	24						TGACTACTGAACTTAAAATCt	0.308000													14	29					0	0	1	0	0
RILP	83547	broad.mit.edu	37	17	1551226	1551226	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr17:1551226G>A	ENST00000301336.6	-	6	1119	c.847C>T	c.(847-849)Ccc>Tcc	p.P283S		NM_031430.2	NP_113618.2	Q96NA2	RILP_HUMAN	Rab interacting lysosomal protein	283	Necessary for the interaction with RAB7 and RAB34, lysosomal distribution and morphology.				endosome to lysosome transport|protein transport	late endosome membrane|lysosomal membrane|phagocytic vesicle membrane	Rab GTPase binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(4)	15				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		AGAAGGCCGGGGACCCGGTGG	0.602000													25	36					0	0	1	0	0
HHIPL1	84439	broad.mit.edu	37	14	100118593	100118593	+	Silent	SNP	C	C	T	rs142575301		TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr14:100118593C>T	ENST00000330710.5	+	2	386	c.288C>T	c.(286-288)gaC>gaT	p.D96D	HHIPL1_ENST00000357223.2_Silent_p.D96D	NM_001127258.1	NP_001120730.1	Q96JK4	HIPL1_HUMAN	HHIP-like 1	96					carbohydrate metabolic process	extracellular region|membrane	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding|scavenger receptor activity			breast(1)|endometrium(2)|large_intestine(2)|lung(8)|skin(2)	15		Melanoma(154;0.128)				ACCTCTATGACGCCGAGGACC	0.602000													27	68					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21857887	21857887	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr7:21857887G>A	ENST00000328843.6	+	66	10673	c.10642G>A	c.(10642-10644)Gaa>Aaa	p.E3548K	DNAH11_ENST00000409508.3_Missense_Mutation_p.E3541K			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	3548	AAA 5 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						CATCTTAATTGAAAATCTCGA	0.328000									Kartagener syndrome				38	22					0	0	1	0	0
IL2RB	3560	broad.mit.edu	37	22	37524480	37524480	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr22:37524480G>C	ENST00000216223.5	-	10	1510	c.1312C>G	c.(1312-1314)Ccc>Gcc	p.P438A		NM_000878.3	NP_000869.1	P14784	IL2RB_HUMAN	interleukin 2 receptor, beta	438					interspecies interaction between organisms|positive regulation of survival gene product expression|protein complex assembly	external side of plasma membrane|integral to plasma membrane	interleukin-2 receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|skin(5)	23					Aldesleukin(DB00041)|Basiliximab(DB00074)|Daclizumab(DB00111)|Denileukin diftitox(DB00004)	GGGGGGCTGGGGCCACCGAGG	0.672000													23	23					0	0	1	0	0
SRRM2	23524	broad.mit.edu	37	16	2820448	2820448	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr16:2820448C>T	ENST00000301740.8	+	13	8666	c.8117C>T	c.(8116-8118)tCa>tTa	p.S2706L		NM_016333.3	NP_057417.3	Q9UQ35	SRRM2_HUMAN	serine/arginine repetitive matrix 2	2706	Arg-rich.|Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|lung(34)|ovary(6)|pancreas(3)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(7)	105						CCCCAGCCCTCACCACGGGAC	0.642000													7	12					0	0	1	0	0
CNKSR1	10256	broad.mit.edu	37	1	26514993	26514993	+	Splice_Site	SNP	C	C	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr1:26514993C>T	ENST00000531191.1	+	17	1822	c.815C>T	c.(814-816)tCg>tTg	p.S272L	CNKSR1_ENST00000374253.5_Splice_Site_p.S537L|CNKSR1_ENST00000361530.6_Splice_Site_p.S530L			Q969H4	CNKR1_HUMAN	connector enhancer of kinase suppressor of Ras 1	537	PDZ.				Rho protein signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway	cell cortex|cell-cell junction	protein binding, bridging			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(8)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	28		Colorectal(325;3.46e-05)|all_lung(284;0.000116)|Lung NSC(340;0.000154)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;2.72e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00072)|BRCA - Breast invasive adenocarcinoma(304;0.000959)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00823)|READ - Rectum adenocarcinoma(331;0.0649)		CACTCAGCCTCGGTGAGTGGG	0.637000													7	13					0	0	1	0	0
MRPS16	51021	broad.mit.edu	37	10	75011600	75011600	+	Silent	SNP	G	G	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr10:75011600G>A	ENST00000372945.3	-	2	405	c.195C>T	c.(193-195)ctC>ctT	p.L65L	MRPS16_ENST00000416782.2_Silent_p.L65L|MRPS16_ENST00000479005.1_5'UTR|MRPS16_ENST00000372940.3_Silent_p.L65L|DNAJC9-AS1_ENST00000440197.2_RNA	NM_016065.3	NP_057149.1	Q9Y3D3	RT16_HUMAN	mitochondrial ribosomal protein S16	65					translation	mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome			large_intestine(2)|lung(2)	4	Prostate(51;0.0119)					TGAGGGCAACGAGTTTTTCTC	0.537000													50	113					0	0	1	0	0
COL22A1	169044	broad.mit.edu	37	8	139609214	139609214	+	Splice_Site	SNP	C	C	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr8:139609214C>T	ENST00000303045.6	-	62	4812		c.e62-1		COL22A1_ENST00000341807.4_Splice_Site|COL22A1_ENST00000435777.1_Splice_Site	NM_152888.1	NP_690848.1	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1						cell adhesion	collagen|cytoplasm	structural molecule activity	p.?(1)		breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			GAGACTCCCCCTAGGAGGGAG	0.507000										HNSCC(7;0.00092)			44	84					0	0	1	0	0
HSDL2	84263	broad.mit.edu	37	9	115171290	115171290	+	Silent	SNP	C	C	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr9:115171290C>T	ENST00000398805.3	+	4	611	c.384C>T	c.(382-384)ggC>ggT	p.G128G	HSDL2_ENST00000488101.1_3'UTR|HSDL2_ENST00000398803.1_Intron|HSDL2_ENST00000539114.1_5'UTR|HSDL2_ENST00000262542.7_Silent_p.G8G	NM_032303.4	NP_115679.2	Q6YN16	HSDL2_HUMAN	hydroxysteroid dehydrogenase like 2	128						peroxisome	oxidoreductase activity|sterol binding			NS(1)|breast(2)|cervix(2)|endometrium(1)|large_intestine(2)|lung(2)|prostate(1)|upper_aerodigestive_tract(2)	13						ACACCAGAGGCACCTACCTTG	0.418000													28	59					0	0	1	0	0
LAMP2	3920	broad.mit.edu	37	X	119589270	119589270	+	Silent	SNP	G	G	A	rs147369153	byFrequency	TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chrX:119589270G>A	ENST00000371335.4	-	3	475	c.339C>T	c.(337-339)agC>agT	p.S113S	LAMP2_ENST00000434600.2_Silent_p.S113S|LAMP2_ENST00000540603.1_Silent_p.S66S|LAMP2_ENST00000538785.1_Intron|LAMP2_ENST00000200639.4_Silent_p.S113S	NM_013995.2	NP_054701.1	P13473	LAMP2_HUMAN	lysosomal-associated membrane protein 2	113	First lumenal domain.				platelet activation|platelet degranulation	endosome membrane|integral to membrane|late endosome|lysosomal membrane|membrane fraction|plasma membrane|platelet dense granule membrane				endometrium(4)|large_intestine(2)|lung(5)|ovary(2)|urinary_tract(2)	15						AAAATGAGACGCTGTCAATTG	0.403000													35	24					0	0	1	0	0
NEO1	4756	broad.mit.edu	37	15	73428236	73428236	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr15:73428236G>A	ENST00000339362.5	+	6	1330	c.883G>A	c.(883-885)Gaa>Aaa	p.E295K	NEO1_ENST00000558964.1_Missense_Mutation_p.E295K|NEO1_ENST00000560262.1_Missense_Mutation_p.E295K|NEO1_ENST00000261908.6_Missense_Mutation_p.E295K			Q92859	NEO1_HUMAN	neogenin 1	295	Ig-like C2-type 3.				axon guidance|cell adhesion|positive regulation of muscle cell differentiation	Golgi apparatus|integral to plasma membrane|nucleus				NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(9)|lung(26)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(2)	57						ACACAGCTCTGAAAGATTGGT	0.338000													5	8					0	0	1	0	0
STARD3	10948	broad.mit.edu	37	17	37809815	37809815	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr17:37809815G>A	ENST00000336308.5	+	2	249	c.31G>A	c.(31-33)Gac>Aac	p.D11N	STARD3_ENST00000580611.1_Missense_Mutation_p.D11N|STARD3_ENST00000394250.4_Missense_Mutation_p.D11N|STARD3_ENST00000578232.1_Intron|STARD3_ENST00000544210.2_Missense_Mutation_p.D11N	NM_001165937.1|NM_006804.3	NP_001159409.1|NP_006795.3	Q14849	STAR3_HUMAN	StAR-related lipid transfer (START) domain containing 3	11					cholesterol metabolic process|mitochondrial transport|steroid biosynthetic process	integral to membrane|late endosome membrane	cholesterol binding|cholesterol transporter activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|pancreas(1)|prostate(2)|stomach(1)	14	Lung NSC(9;1.15e-09)|all_lung(9;6.24e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|BRCA - Breast invasive adenocarcinoma(8;1.04e-44)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			GCTGACCCGAGACTTGGAGCG	0.716000											OREG0024381	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	74					0	0	1	0	0
PCDHGB1	56104	broad.mit.edu	37	5	140730728	140730728	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr5:140730728G>A	ENST00000523390.1	+	1	901	c.901G>A	c.(901-903)Ggc>Agc	p.G301S	PCDHGA3_ENST00000253812.6_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_018922.2|NM_032095.1	NP_061745.1|NP_115266.1														central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)	16			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACAACCAATGGCACATTGGA	0.418000													47	97					0	0	1	0	0
GLI2	2736	broad.mit.edu	37	2	121708927	121708927	+	Nonsense_Mutation	SNP	C	C	G			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr2:121708927C>G	ENST00000452319.1	+	4	423	c.363C>G	c.(361-363)taC>taG	p.Y121*	GLI2_ENST00000361492.4_Nonsense_Mutation_p.Y121*|GLI2_ENST00000314490.11_5'UTR|GLI2_ENST00000435313.2_3'UTR			P10070	GLI2_HUMAN	GLI family zinc finger 2	121					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|lung(24)|ovary(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(3;0.0496)	Prostate(154;0.0623)				CCCACCCGTACGTGAACCCCC	0.657000													8	84					0	0	1	0	0
GOLGA4	2803	broad.mit.edu	37	3	37336557	37336557	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr3:37336557C>G	ENST00000361924.2	+	6	1044	c.670C>G	c.(670-672)Ctc>Gtc	p.L224V	GOLGA4_ENST00000435830.2_3'UTR|GOLGA4_ENST00000444882.1_Intron|GOLGA4_ENST00000356847.4_Missense_Mutation_p.L246V	NM_002078.4	NP_002069.2	Q13439	GOGA4_HUMAN	golgin A4	224					Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding			NS(2)|breast(3)|central_nervous_system(3)|endometrium(6)|kidney(2)|large_intestine(17)|liver(2)|lung(16)|ovary(4)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	65						TATCAGTGTTCTCCAAACTCA	0.363000													36	85					0	0	1	0	0
DOCK5	80005	broad.mit.edu	37	8	25267711	25267711	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr8:25267711C>G	ENST00000276440.7	+	51	5545	c.5501C>G	c.(5500-5502)tCc>tGc	p.S1834C		NM_024940.6	NP_079216.4	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	1834	Pro-rich.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(9)|large_intestine(13)|lung(20)|ovary(3)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	72		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		CAGAGGAACTCCACTGAGGTA	0.592000													15	29					0	0	1	0	0
ERC2	26059	broad.mit.edu	37	3	56468686	56468686	+	Missense_Mutation	SNP	T	T	C			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr3:56468686T>C	ENST00000288221.6	-	2	605	c.350A>G	c.(349-351)tAc>tGc	p.Y117C		NM_015576.1	NP_056391.1	O15083	ERC2_HUMAN	ELKS/RAB6-interacting/CAST family member 2	117						cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			breast(2)|endometrium(5)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|urinary_tract(1)	31				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		TTGATCTGTGTATGAAAGGAC	0.507000													69	174					0	0	1	0	0
NOP9	161424	broad.mit.edu	37	14	24769970	24769970	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr14:24769970C>T	ENST00000267425.3	+	2	697	c.604C>T	c.(604-606)Cat>Tat	p.H202Y	NOP9_ENST00000396802.3_Missense_Mutation_p.H202Y	NM_174913.1	NP_777573.1			NOP9 nucleolar protein																		TGGAGACACACATGGCAGCTT	0.547000													54	107					0	0	1	0	0
KLF5	688	broad.mit.edu	37	13	73649892	73649892	+	Silent	SNP	C	C	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr13:73649892C>T	ENST00000377687.4	+	4	1778	c.1242C>T	c.(1240-1242)ttC>ttT	p.F414F	KLF5_ENST00000539231.1_Silent_p.F323F	NM_001730.3	NP_001721.2	Q13887	KLF5_HUMAN	Kruppel-like factor 5 (intestinal)	414					transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Prostate(6;0.00187)|Breast(118;0.0735)		GBM - Glioblastoma multiforme(99;0.0011)		ACTGGAGGTTCGCGCGATCGG	0.582000													43	108					0	0	1	0	0
TSPAN6	7105	broad.mit.edu	37	X	99888429	99888429	+	Silent	SNP	C	C	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chrX:99888429C>T	ENST00000373020.4	-	5	669	c.558G>A	c.(556-558)caG>caA	p.Q186Q	TSPAN6_ENST00000496771.1_5'UTR	NM_001278740.1|NM_001278741.1|NM_003270.2	NP_001265669.1|NP_001265670.1|NP_003261.1	O43657	TSN6_HUMAN	tetraspanin 6	186					positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane	signal transducer activity			endometrium(2)|kidney(3)|large_intestine(6)|ovary(1)	12						CTGCATCTCTCTGTGGAGTAC	0.338000													29	19					0	0	1	0	0
ZFP37	7539	broad.mit.edu	37	9	115805288	115805288	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr9:115805288C>G	ENST00000374227.3	-	4	1637	c.1610G>C	c.(1609-1611)aGa>aCa	p.R537T	ZFP37_ENST00000553380.1_Missense_Mutation_p.R552T|ZFP37_ENST00000555206.1_Missense_Mutation_p.R538T	NM_001282515.1|NM_001282518.1	NP_001269444.1|NP_001269447.1	Q9Y6Q3	ZFP37_HUMAN	ZFP37 zinc finger protein	537						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	38						AGTATGAACTCTCTGATGTTG	0.403000													30	47					0	0	1	0	0
HSP90AB2P	391634	broad.mit.edu	37	4	13338307	13338307	+	RNA	SNP	G	G	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr4:13338307G>A	ENST00000602906.1	+	0	325																				kidney(3)|lung(1)	4						GTTGGACAGTGGTAAAGAGCT	0.428000													20	33					0	0	1	0	0
PIPSL	266971	broad.mit.edu	37	10	95718600	95718600	+	RNA	SNP	T	T	C	rs11815169	by1000genomes	TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr10:95718600T>C	ENST00000480546.1	-	0	2697					NR_002319.2																						TCCTTCTTGCTGTCCTTGGTG	0.547000													5	74					0	0	1	0	0
PIGU	128869	broad.mit.edu	37	20	33162908	33162908	+	Splice_Site	SNP	C	C	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr20:33162908C>T	ENST00000374820.2	-	10	1154	c.1134G>A	c.(1132-1134)caG>caA	p.Q378Q	PIGU_ENST00000452740.2_Splice_Site_p.Q398Q			Q9H490	PIGU_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class U	398					attachment of GPI anchor to protein|C-terminal protein lipidation|regulation of JAK-STAT cascade	GPI-anchor transamidase complex|plasma membrane				NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(1)|skin(1)	9						TCCCTCTTACCTGCCCAACGT	0.522000													37	81					0	0	1	0	0
LRRN1	57633	broad.mit.edu	37	3	3887651	3887651	+	Silent	SNP	G	G	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr3:3887651G>A	ENST00000319331.3	+	2	2087	c.1326G>A	c.(1324-1326)acG>acA	p.T442T	SUMF1_ENST00000534863.1_Intron	NM_020873.5	NP_065924.3	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1	442	Ig-like C2-type.					integral to membrane				NS(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)|skin(1)|urinary_tract(2)	26				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		TCGGCACGACGGTTTTCCTAG	0.448000													31	102					0	0	1	0	0
RPL13	6137	broad.mit.edu	37	16	89629441	89629441	+	Missense_Mutation	SNP	G	G	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr16:89629441G>T	ENST00000393099.3	+	5	876	c.627G>T	c.(625-627)aaG>aaT	p.K209N	RPL13_ENST00000567815.1_Missense_Mutation_p.K209N|RPL13_ENST00000452368.3_Missense_Mutation_p.K162N|RPL13_ENST00000311528.5_Missense_Mutation_p.K209N	NM_033251.2	NP_150254.1	P26373	RL13_HUMAN	ribosomal protein L13	209					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic ribosome	protein binding|RNA binding|structural constituent of ribosome			lung(3)|skin(1)|upper_aerodigestive_tract(2)	6		all_hematologic(23;0.0748)		all cancers(4;1.15e-07)|OV - Ovarian serous cystadenocarcinoma(4;7.8e-06)|BRCA - Breast invasive adenocarcinoma(80;0.0139)		ATGTTGAAAAGAAAAAATAAA	0.557000													12	21					2.10051e-16	2.21377e-16	1	1	0
DMBT1	1755	broad.mit.edu	37	10	124348479	124348479	+	Silent	SNP	C	C	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr10:124348479C>T	ENST00000368909.3	+	17	1909	c.1803C>T	c.(1801-1803)gcC>gcT	p.A601A	DMBT1_ENST00000359586.6_Intron|DMBT1_ENST00000330163.4_Intron|DMBT1_ENST00000344338.3_Silent_p.A591A|DMBT1_ENST00000368955.3_Silent_p.A591A|DMBT1_ENST00000368956.2_Intron|DMBT1_ENST00000338354.3_Silent_p.A601A	NM_007329.2	NP_015568.2	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	601					epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				CCAGTTTGGCCCTGAGGCTGG	0.542000													8	5					0	0	1	0	0
OLIG3	167826	broad.mit.edu	37	6	137815072	137815072	+	Missense_Mutation	SNP	T	T	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr6:137815072T>A	ENST00000367734.2	-	1	459	c.236A>T	c.(235-237)cAg>cTg	p.Q79L		NM_175747.2	NP_786923.1	Q7RTU3	OLIG3_HUMAN	oligodendrocyte transcription factor 3	79					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			endometrium(2)|large_intestine(2)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	11	Breast(32;0.165)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00161)|OV - Ovarian serous cystadenocarcinoma(155;0.00447)		CTGTAGGTCCTGCTCCGACAG	0.597000													63	120					0	0	1	0	0
ITIH2	3698	broad.mit.edu	37	10	7774363	7774363	+	Silent	SNP	G	G	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr10:7774363G>A	ENST00000358415.4	+	14	1876	c.1710G>A	c.(1708-1710)tcG>tcA	p.S570S	ITIH2_ENST00000379587.4_Silent_p.S559S	NM_002216.2	NP_002207.2	P19823	ITIH2_HUMAN	inter-alpha-trypsin inhibitor heavy chain 2	570					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(2)|breast(1)|endometrium(8)|kidney(1)|large_intestine(17)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	64						ATTTTCTATCGAAAGACAAGC	0.483000													13	43					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103488345	103488345	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr1:103488345C>G	ENST00000358392.2	-	8	1551	c.1234G>C	c.(1234-1236)Gaa>Caa	p.E412Q	COL11A1_ENST00000353414.4_Missense_Mutation_p.E361Q|COL11A1_ENST00000512756.1_Intron|COL11A1_ENST00000370096.3_Missense_Mutation_p.E400Q	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	400	Nonhelical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		GGACCAAATTCTTCATTAGGG	0.363000													28	81					0	0	1	0	0
ANKRD30BP2	149992	broad.mit.edu	37	21	14414902	14414902	+	RNA	SNP	G	G	A	rs2821609	by1000genomes	TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr21:14414902G>A	ENST00000507941.1	+	0	95																											CCAGCTTGACGTCCTTGATGG	0.443000													10	50					0	0	1	0	0
SYNE3	161176	broad.mit.edu	37	14	95884264	95884264	+	Silent	SNP	G	G	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr14:95884264G>A	ENST00000334258.5	-	17	2841	c.2827C>T	c.(2827-2829)Ctg>Ttg	p.L943L	SYNE3_ENST00000557275.1_Silent_p.L938L|SYNE3_ENST00000554873.1_Silent_p.L700L	NM_152592.3	NP_689805.3			spectrin repeat containing, nuclear envelope family member 3											breast(1)|endometrium(2)|lung(25)	28						ATTGGGagcaggaacagcagg	0.647000													47	74					0	0	1	0	0
ANKRD55	79722	broad.mit.edu	37	5	55407474	55407474	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr5:55407474C>A	ENST00000341048.4	-	10	1252	c.1101G>T	c.(1099-1101)agG>agT	p.R367S	ANKRD55_ENST00000434982.2_Missense_Mutation_p.R79S|ANKRD55_ENST00000504958.2_Missense_Mutation_p.R324S|ANKRD55_ENST00000505970.2_5'UTR	NM_024669.2	NP_078945.2	Q3KP44	ANR55_HUMAN	ankyrin repeat domain 55	366										breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(17)|ovary(1)|prostate(1)|skin(2)|stomach(1)	34		Lung NSC(810;8.69e-05)|Prostate(74;0.00634)|Breast(144;0.0334)|Ovarian(174;0.223)				TGTATCGGTCCCTGCTGGGAT	0.507000													81	185					4.45923e-32	4.91658e-32	1	1	0
PCDHA4	56144	broad.mit.edu	37	5	140188665	140188665	+	Silent	SNP	C	C	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr5:140188665C>T	ENST00000530339.1	+	1	1893	c.1893C>T	c.(1891-1893)atC>atT	p.I631I	PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000512229.2_Silent_p.I631I|PCDHA4_ENST00000356878.4_Silent_p.I631I|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018907.2	NP_061730.1														breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(6)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGGCGAGATCAGCACAACGC	0.682000													59	132					0	0	1	0	0
SLC5A3	6526	broad.mit.edu	37	21	35468622	35468622	+	Silent	SNP	G	G	C			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr21:35468622G>C	ENST00000608209.1	+	2	1637	c.1125G>C	c.(1123-1125)ctG>ctC	p.L375L	MRPS6_ENST00000399312.2_Intron|SLC5A3_ENST00000381151.3_Silent_p.L375L|AP000320.7_ENST00000362077.4_RNA	NM_006933.4	NP_008864.3	P53794	SC5A3_HUMAN	solute carrier family 5 (sodium/myo-inositol cotransporter), member 3							integral to plasma membrane	myo-inositol:sodium symporter activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	20						TTGCAGCTCTGATGAGTGACT	0.493000													24	45					0	0	1	0	0
LRSAM1	90678	broad.mit.edu	37	9	130217858	130217858	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr9:130217858C>G	ENST00000323301.4	+	4	737	c.133C>G	c.(133-135)Cca>Gca	p.P45A	LRSAM1_ENST00000300417.6_Missense_Mutation_p.P45A|LRSAM1_ENST00000373322.1_Missense_Mutation_p.P45A|LRSAM1_ENST00000373324.4_Missense_Mutation_p.P45A	NM_138361.5	NP_612370.3	Q6UWE0	LRSM1_HUMAN	leucine rich repeat and sterile alpha motif containing 1	45					negative regulation of endocytosis|non-lytic virus budding|protein autoubiquitination|protein catabolic process|protein polyubiquitination|protein transport|ubiquitin-dependent endocytosis	cytoplasm|extracellular region|membrane part	hormone activity|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|ovary(2)	16						ATCTTAGATTCCATTTGGAGC	0.438000													29	60					0	0	1	0	0
HDAC4	9759	broad.mit.edu	37	2	240061422	240061422	+	Silent	SNP	C	C	T	rs138989369	byFrequency	TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr2:240061422C>T	ENST00000345617.3	-	9	1727	c.936G>A	c.(934-936)gcG>gcA	p.A312A	HDAC4_ENST00000541256.1_Silent_p.A281A|HDAC4_ENST00000543185.1_5'UTR|HDAC4_ENST00000553145.1_5'UTR	NM_006037.3	NP_006028.2	P56524	HDAC4_HUMAN	histone deacetylase 4	312	Interaction with MEF2A.				B cell differentiation|cardiac muscle hypertrophy in response to stress|chromatin remodeling|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of glycolysis|negative regulation of myotube differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development|peptidyl-lysine deacetylation|positive regulation of cell proliferation|positive regulation of protein sumoylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|response to denervation involved in regulation of muscle adaptation|response to interleukin-1|transcription, DNA-dependent	histone deacetylase complex|transcriptional repressor complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|potassium ion binding|repressing transcription factor binding|zinc ion binding	p.A312A(1)		NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|kidney(2)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(5)	62		all_epithelial(40;1.45e-17)|Breast(86;1.53e-05)|Renal(207;0.000355)|all_lung(227;0.0121)|Ovarian(221;0.0183)|Lung NSC(271;0.0413)|Melanoma(123;0.0749)|all_hematologic(139;0.159)		Epithelial(121;6.38e-25)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-12)|Kidney(56;6.04e-08)|KIRC - Kidney renal clear cell carcinoma(57;1.18e-06)|BRCA - Breast invasive adenocarcinoma(100;3.99e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.04)		TACCGTTCTCCGCGCTGACGC	0.662000													11	124					0	0	1	0	0
TAF3	83860	broad.mit.edu	37	10	8056618	8056618	+	Missense_Mutation	SNP	G	G	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr10:8056618G>T	ENST00000344293.5	+	7	2900	c.2694G>T	c.(2692-2694)atG>atT	p.M898I		NM_031923.3	NP_114129.1	Q5VWG9	TAF3_HUMAN	TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa	898					maintenance of protein location in nucleus|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	transcription factor TFIID complex	protein binding|zinc ion binding			NS(2)|breast(4)|endometrium(2)|kidney(1)|large_intestine(6)|lung(16)|ovary(3)|prostate(4)|skin(2)	40						TTGGAATCATGACTGCACCCC	0.448000													3	18					6.4e-05	6.46009e-05	1	1	0
FGR	2268	broad.mit.edu	37	1	27943478	27943478	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr1:27943478C>G	ENST00000374005.3	-	7	860	c.572G>C	c.(571-573)aGa>aCa	p.R191T	FGR_ENST00000399173.1_Missense_Mutation_p.R191T|FGR_ENST00000374004.1_Missense_Mutation_p.R191T|FGR_ENST00000545953.1_Missense_Mutation_p.R125T	NM_005248.2	NP_005239.1	P09769	FGR_HUMAN	feline Gardner-Rasheed sarcoma viral oncogene homolog	191	SH2.				platelet activation|response to virus	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(4)	16		all_lung(284;2.05e-05)|Colorectal(325;3.46e-05)|Lung NSC(340;3.67e-05)|Renal(390;0.00121)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		ATGATCGCCTCTGGTCTGATC	0.557000													50	94					0	0	1	0	0
ZNF733P	643955	broad.mit.edu	37	7	62752443	62752443	+	RNA	SNP	G	G	C			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr7:62752443G>C	ENST00000331425.6	-	0	992					NR_003952.1																						CTTATGTCTAGTAAGGTTTGA	0.438000													5	16					0	0	1	0	0
ZNF510	22869	broad.mit.edu	37	9	99522006	99522006	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr9:99522006C>T	ENST00000375231.1	-	6	1756	c.1106G>A	c.(1105-1107)aGa>aAa	p.R369K	ZNF510_ENST00000223428.4_Missense_Mutation_p.R369K			Q9Y2H8	ZN510_HUMAN	zinc finger protein 510	369					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(8)|stomach(1)|urinary_tract(1)	21		Acute lymphoblastic leukemia(62;0.0527)				AGTCTGTGTTCTGTCATTACT	0.388000													56	41					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179610937	179610937	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr2:179610937G>A	ENST00000360870.5	-	46	16412	c.16190C>T	c.(16189-16191)gCt>gTt	p.A5397V	TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000589042.1_Intron|TTN_ENST00000342992.6_Intron|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000590773.1_RNA	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	8905	Ig-like 34.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTGAATACAGCATCTGAATT	0.328000													23	30					0	0	1	0	0
OR2F1	26211	broad.mit.edu	37	7	143657782	143657782	+	Missense_Mutation	SNP	C	C	A	rs73464588	byFrequency	TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr7:143657782C>A	ENST00000392899.1	+	1	756	c.719C>A	c.(718-720)aCg>aAg	p.T240K		NM_012369.2	NP_036501.2	Q13607	OR2F1_HUMAN	olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)	240					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(18)|ovary(1)|skin(4)	34	Melanoma(164;0.0903)					GCTTTCCACACGTGTGCCTCT	0.507000													80	90					8.70839e-23	9.40856e-23	1	1	0
SLC5A5	6528	broad.mit.edu	37	19	17992856	17992856	+	Missense_Mutation	SNP	A	A	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr19:17992856A>T	ENST00000222248.3	+	9	1493	c.1146A>T	c.(1144-1146)aaA>aaT	p.K382N		NM_000453.2	NP_000444.1	Q92911	SC5A5_HUMAN	solute carrier family 5 (sodium/iodide cotransporter), member 5	382					cellular nitrogen compound metabolic process|cellular response to cAMP|cellular response to gonadotropin stimulus|hormone biosynthetic process	integral to membrane|nucleus|plasma membrane	iodide transmembrane transporter activity|sodium:iodide symporter activity			NS(2)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(6)|lung(13)|ovary(1)|prostate(1)|skin(3)	31						CACCCAGGAAACTCGTGATTA	0.577000													28	52					0	0	1	0	0
ZNF841	284371	broad.mit.edu	37	19	52568806	52568806	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr19:52568806G>A	ENST00000389534.4	-	7	2788	c.2329C>T	c.(2329-2331)Cgc>Tgc	p.R777C	ZNF841_ENST00000594295.1_Missense_Mutation_p.R777C|ZNF841_ENST00000426391.2_Missense_Mutation_p.R661C|ZNF432_ENST00000598446.1_Intron|ZNF841_ENST00000359973.2_Missense_Mutation_p.R353C	NM_001136499.1	NP_001129971.1	Q6ZN19	ZN841_HUMAN	zinc finger protein 841	661					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(3)|lung(3)	11						AGGCCTGAGCGATAACGGAAG	0.428000													15	29					0	0	1	0	0
REEP2	51308	broad.mit.edu	37	5	137777134	137777134	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr5:137777134G>A	ENST00000378339.2	+	3	358	c.166G>A	c.(166-168)Gat>Aat	p.D56N	REEP2_ENST00000254901.5_Missense_Mutation_p.D56N|REEP2_ENST00000506158.1_Missense_Mutation_p.D18N|REEP2_ENST00000464751.2_3'UTR	NM_001271803.1	NP_001258732.1	Q9BRK0	REEP2_HUMAN	receptor accessory protein 2	56						integral to membrane				endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|urinary_tract(1)	12			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			GACGCTCACGGATATAGTGCT	0.602000													29	57					0	0	1	0	0
GTF3C4	9329	broad.mit.edu	37	9	135555086	135555086	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr9:135555086G>A	ENST00000372146.4	+	2	2644	c.2080G>A	c.(2080-2082)Gaa>Aaa	p.E694K		NM_012204.2	NP_036336.2	Q9UKN8	TF3C4_HUMAN	general transcription factor IIIC, polypeptide 4, 90kDa	694					transcription initiation from RNA polymerase III promoter	transcription factor TFIIIC complex	DNA binding|enzyme activator activity|histone acetyltransferase activity|protein binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|skin(1)	20				OV - Ovarian serous cystadenocarcinoma(145;8.15e-07)|Epithelial(140;2.6e-05)		AGTCTTAGGAGAAGTGTATCT	0.478000													30	53					0	0	1	0	0
COL4A1	1282	broad.mit.edu	37	13	110830437	110830437	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr13:110830437C>T	ENST00000375820.4	-	32	2721	c.2600G>A	c.(2599-2601)gGg>gAg	p.G867E		NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	867	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			CCCAGGAGCCCCCTGCTGTCC	0.547000													50	109					0	0	1	0	0
MTMR1	8776	broad.mit.edu	37	X	149900044	149900044	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chrX:149900044G>A	ENST00000445323.2	+	9	965	c.844G>A	c.(844-846)Gat>Aat	p.D282N	MTMR1_ENST00000541925.1_Missense_Mutation_p.D180N|MTMR1_ENST00000544228.1_Missense_Mutation_p.D274N|MTMR1_ENST00000370390.3_Missense_Mutation_p.D274N|MTMR1_ENST00000451863.2_Missense_Mutation_p.D274N|MTMR1_ENST00000538506.1_Missense_Mutation_p.D161N|MTMR1_ENST00000542156.1_Missense_Mutation_p.D274N			Q13613	MTMR1_HUMAN	myotubularin related protein 1	274	Myotubularin phosphatase.					plasma membrane	protein tyrosine phosphatase activity			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(5)|ovary(2)|prostate(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					TGTAAAAGATGATGACCTTTC	0.358000													52	30					0	0	1	0	0
MYLK3	91807	broad.mit.edu	37	16	46766181	46766181	+	Silent	SNP	C	C	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr16:46766181C>A	ENST00000394809.4	-	4	1516	c.1401G>T	c.(1399-1401)ccG>ccT	p.P467P	MYLK3_ENST00000536476.1_Silent_p.P126P	NM_182493.2	NP_872299.2	Q32MK0	MYLK3_HUMAN	myosin light chain kinase 3	467					cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(7)|lung(11)|ovary(3)|prostate(3)|skin(5)|stomach(3)	37		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				CAGCTCTCACCGGAGCCCTGG	0.657000													32	61					5.60225e-13	5.84701e-13	1	1	0
FOXC1	2296	broad.mit.edu	37	6	1612318	1612318	+	Silent	SNP	C	C	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr6:1612318C>T	ENST00000380874.2	+	1	1638	c.1638C>T	c.(1636-1638)ttC>ttT	p.F546F		NM_001453.2	NP_001444.2	Q12948	FOXC1_HUMAN	forkhead box C1	546					anti-apoptosis|artery morphogenesis|blood vessel remodeling|brain development|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|germ cell migration|glycosaminoglycan metabolic process|lacrimal gland development|lymphangiogenesis|metanephros development|negative regulation of mitotic cell cycle|neural crest cell fate commitment|Notch signaling pathway|odontogenesis of dentine-containing tooth|ossification|ovarian follicle development|paraxial mesodermal cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|regulation of blood vessel size|regulation of organ growth|regulation of sequence-specific DNA binding transcription factor activity|somitogenesis|ureteric bud development|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	nuclear heterochromatin|transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(1)	8	Ovarian(93;0.0733)	all_cancers(2;4.45e-07)|all_epithelial(2;4.33e-05)|all_lung(73;0.0713)|all_hematologic(90;0.0895)		Epithelial(2;0.0904)|OV - Ovarian serous cystadenocarcinoma(45;0.095)|all cancers(2;0.168)		CCGGAGCTTTCGTCTACGACT	0.498000													14	21					0	0	1	0	0
TGM2	7052	broad.mit.edu	37	20	36760817	36760817	+	Silent	SNP	G	G	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr20:36760817G>A	ENST00000361475.2	-	11	1874	c.1701C>T	c.(1699-1701)ctC>ctT	p.L567L	TGM2_ENST00000536724.1_Silent_p.L507L|TGM2_ENST00000536701.1_Silent_p.L486L	NM_004613.2|NM_198951.1	NP_004604.2|NP_945189.1	P21980	TGM2_HUMAN	transglutaminase 2	567					apoptotic cell clearance|peptide cross-linking|positive regulation of cell adhesion		acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			endometrium(2)|large_intestine(11)|liver(1)|lung(7)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		Myeloproliferative disorder(115;0.00878)			L-Glutamine(DB00130)	CTGGCTCCACGAGGAGGGCCC	0.557000													93	216					0	0	1	0	0
GPAT2	150763	broad.mit.edu	37	2	96690055	96690055	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr2:96690055C>T	ENST00000434632.1	-	17	2159	c.1700G>A	c.(1699-1701)aGa>aAa	p.R567K	GPAT2_ENST00000453542.1_Missense_Mutation_p.R496K|GPAT2_ENST00000377137.3_Missense_Mutation_p.R567K|GPAT2_ENST00000359548.4_Missense_Mutation_p.R567K			Q6NUI2	GPAT2_HUMAN	glycerol-3-phosphate acyltransferase 2, mitochondrial	567					glycerol-3-phosphate metabolic process|phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity			NS(1)|breast(1)|cervix(1)|endometrium(4)|large_intestine(1)|lung(5)|skin(3)	16						GGGCGGCACTCTGCCTGCCAG	0.642000													25	23					0	0	1	0	0
ARHGAP5	394	broad.mit.edu	37	14	32561150	32561150	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr14:32561150G>C	ENST00000345122.3	+	2	1590	c.1275G>C	c.(1273-1275)aaG>aaC	p.K425N	ARHGAP5_ENST00000396582.2_Intron|ARHGAP5_ENST00000432921.1_Missense_Mutation_p.K425N|ARHGAP5_ENST00000539826.2_Missense_Mutation_p.K425N|ARHGAP5_ENST00000556611.1_Missense_Mutation_p.K425N|ARHGAP5_ENST00000433497.1_Intron	NM_001030055.1	NP_001025226.1	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5	425					cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(10)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(12)|ovary(4)|skin(1)|stomach(1)|urinary_tract(4)	55	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		TATCCGAGAAGAGGAGGGTGG	0.393000													38	58					0	0	1	0	0
KIAA0232	9778	broad.mit.edu	37	4	6862671	6862671	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr4:6862671C>G	ENST00000307659.5	+	7	1017	c.562C>G	c.(562-564)Ctg>Gtg	p.L188V	KIAA0232_ENST00000425103.1_Missense_Mutation_p.L188V	NM_014743.2	NP_055558.2	Q92628	K0232_HUMAN	KIAA0232	188							ATP binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(12)|ovary(2)|prostate(4)|skin(1)|urinary_tract(1)	41						ACCAGTTTGCCTGCAAGAAAT	0.408000													50	97					0	0	1	0	0
LRRIQ3	127255	broad.mit.edu	37	1	74506961	74506961	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr1:74506961C>A	ENST00000354431.4	-	7	1845	c.1654G>T	c.(1654-1656)Gtt>Ttt	p.V552F	LRRIQ3_ENST00000395089.1_Missense_Mutation_p.V552F	NM_001105659.1	NP_001099129.1	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	552										NS(2)|breast(1)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(13)|liver(1)|lung(27)|ovary(3)|prostate(1)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(5)	73						TTTTGCTTAACAATCAGGCTT	0.313000													32	45					2.2171e-23	2.40746e-23	1	1	0
SLC8B1	80024	broad.mit.edu	37	12	113742153	113742153	+	Silent	SNP	C	C	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr12:113742153C>T	ENST00000552014.1	-	16	2045	c.1530G>A	c.(1528-1530)caG>caA	p.Q510Q	SLC8B1_ENST00000202831.3_Silent_p.Q510Q|SLC8B1_ENST00000546737.1_Silent_p.Q454Q|SLC8B1_ENST00000550047.1_Silent_p.Q25Q|SLC8B1_ENST00000549069.1_Silent_p.Q69Q					solute carrier family 8 (sodium/lithium/calcium exchanger), member B1	510																	TTCGGGAGATCTGGAGCAGGC	0.542000													48	182					0	0	1	0	0
SELP	6403	broad.mit.edu	37	1	169566333	169566333	+	Missense_Mutation	SNP	G	G	A	rs143148749		TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr1:169566333G>A	ENST00000263686.6	-	11	1824	c.1787C>T	c.(1786-1788)tCc>tTc	p.S596F	SELP_ENST00000367792.2_Intron|SELP_ENST00000458599.2_Intron|SELP_ENST00000367793.2_Missense_Mutation_p.S534F|SELP_ENST00000367791.2_Intron|SELP_ENST00000367794.2_Missense_Mutation_p.S534F|SELP_ENST00000367788.2_Missense_Mutation_p.S534F|SELP_ENST00000367786.2_Missense_Mutation_p.S534F	NM_003005.3	NP_002996.2	P16109	LYAM3_HUMAN	selectin P (granule membrane protein 140kDa, antigen CD62)	596	Sushi 7.				platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(32)|ovary(4)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	ATGGCAGGTGGAGCCAACATT	0.498000													29	33					0	0	1	0	0
LAMA2	3908	broad.mit.edu	37	6	129794495	129794495	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr6:129794495G>C	ENST00000421865.2	+	52	7486	c.7437G>C	c.(7435-7437)ttG>ttC	p.L2479F		NM_000426.3|NM_001079823.1	NP_000417|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	2479	Laminin G-like 2.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		TGAGAAACTTGAGGTAATTTA	0.333000													26	48					0	0	1	0	0
MEFV	4210	broad.mit.edu	37	16	3297033	3297033	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr16:3297033C>T	ENST00000219596.1	-	5	1609	c.1570G>A	c.(1570-1572)Gaa>Aaa	p.E524K	MEFV_ENST00000541159.1_Missense_Mutation_p.E313K|MEFV_ENST00000339854.4_Missense_Mutation_p.E344K|MEFV_ENST00000536379.1_Missense_Mutation_p.E313K	NM_000243.2	NP_000234.1	O15553	MEFV_HUMAN	Mediterranean fever	524					inflammatory response	cytoplasm|microtubule|microtubule associated complex|nucleus	actin binding|zinc ion binding			NS(2)|biliary_tract(1)|breast(5)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(19)|ovary(3)|prostate(1)|skin(6)	50					Colchicine(DB01394)	AGTTCCCATTCTGACTGGCAC	0.617000													51	74					0	0	1	0	0
SERPINB11	89778	broad.mit.edu	37	18	61383320	61383320	+	RNA	SNP	G	G	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr18:61383320G>A	ENST00000544088.1	+	0	471				SERPINB11_ENST00000536691.1_RNA|SERPINB11_ENST00000382749.5_RNA|SERPINB11_ENST00000538847.1_RNA|SERPINB11_ENST00000489748.1_RNA	NM_080475.2	NP_536723.2	Q96P15	SPB11_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene)						regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			breast(1)|cervix(1)|kidney(1)|lung(3)	6		Esophageal squamous(42;0.129)				GCAAACTGTGGATTTTGAACA	0.343000													18	10					0	0	1	0	0
CHIT1	1118	broad.mit.edu	37	1	203194936	203194936	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr1:203194936G>A	ENST00000367229.1	-	3	152	c.118C>T	c.(118-120)Cgc>Tgc	p.R40C	CHIT1_ENST00000484834.1_5'UTR|CHIT1_ENST00000255427.3_Missense_Mutation_p.R40C|CHIT1_ENST00000535569.1_Missense_Mutation_p.R50C	NM_001270509.1|NM_003465.2	NP_001257438.1|NP_003456.1	Q13231	CHIT1_HUMAN	chitinase 1 (chitotriosidase)	40			R -> H (in dbSNP:rs35920428).		chitin catabolic process|immune response|response to bacterium	extracellular space|lysosome	cation binding|chitin binding|endochitinase activity	p.R40C(1)		central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(13)|ovary(1)|stomach(2)	27						GGCAGGAAGCGAGCCTCCCCC	0.577000													32	52					0	0	1	0	0
ABCC4	10257	broad.mit.edu	37	13	95813572	95813572	+	Missense_Mutation	SNP	C	C	T	rs146708960		TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr13:95813572C>T	ENST00000376887.4	-	19	2440	c.2326G>A	c.(2326-2328)Gtt>Att	p.V776I	ABCC4_ENST00000536256.1_Missense_Mutation_p.V701I|ABCC4_ENST00000412704.1_Missense_Mutation_p.V729I|ABCC4_ENST00000431522.1_Missense_Mutation_p.V776I	NM_005845.3	NP_005836.2	O15439	MRP4_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	776	ABC transmembrane type-1 2.		V -> I (20% reduced expression level compared to wild-type; significant lower activity in 6-mercaptopurine transport than wild-type).		platelet activation|platelet degranulation	integral to membrane|membrane fraction|plasma membrane|platelet dense granule membrane	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|chloride channel activity			breast(1)|central_nervous_system(4)|endometrium(5)|kidney(4)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	43	all_neural(89;0.0878)|Medulloblastoma(90;0.163)				Cefazolin(DB01327)	CCAAAAAGAACGGTAGCTACA	0.358000													10	39					0	0	1	0	0
TMX2	51075	broad.mit.edu	37	11	57505121	57505121	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr11:57505121G>A	ENST00000278422.4	+	2	243	c.231G>A	c.(229-231)atG>atA	p.M77I	TMX2-CTNND1_ENST00000528395.1_Missense_Mutation_p.M77I|TMX2_ENST00000378312.4_Missense_Mutation_p.M77I	NM_015959.3	NP_057043.1	Q9Y320	TMX2_HUMAN	thioredoxin-related transmembrane protein 2	77					cell redox homeostasis	integral to membrane				NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)|urinary_tract(2)	12						CCATTGTGATGATGAAGAACC	0.433000													13	32					0	0	1	0	0
TNRC6A	27327	broad.mit.edu	37	16	24826603	24826603	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr16:24826603C>G	ENST00000395799.3	+	19	4937	c.4808C>G	c.(4807-4809)tCt>tGt	p.S1603C	CTD-2515A14.1_ENST00000568895.1_RNA|TNRC6A_ENST00000315183.7_Missense_Mutation_p.S1554C|TNRC6A_ENST00000432286.2_Missense_Mutation_p.S81C	NM_014494.2	NP_055309.2	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	1603					negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|liver(1)|lung(20)|ovary(3)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	64				GBM - Glioblastoma multiforme(48;0.0394)		CCTAACGGCTCTAGCAGTGTT	0.433000													26	34					0	0	1	0	0
FAM78A	286336	broad.mit.edu	37	9	134136337	134136337	+	Missense_Mutation	SNP	T	T	G			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr9:134136337T>G	ENST00000372271.3	-	2	1091	c.724A>C	c.(724-726)Atc>Ctc	p.I242L	FAM78A_ENST00000372269.3_Missense_Mutation_p.I239L|FAM78A_ENST00000247295.4_5'UTR	NM_033387.3	NP_203745.2	Q5JUQ0	FA78A_HUMAN	family with sequence similarity 78, member A	242										NS(1)|endometrium(1)|large_intestine(2)|lung(3)|ovary(1)|skin(1)	9	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.15e-05)|Epithelial(140;0.000267)		TTGCTCAGGATTTTGGGCTGG	0.682000													58	111					0	0	1	0	0
LPHN3	23284	broad.mit.edu	37	4	62813863	62813863	+	Missense_Mutation	SNP	T	T	C			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr4:62813863T>C	ENST00000512091.2	+	16	3217	c.2470T>C	c.(2470-2472)Tcc>Ccc	p.S824P	LPHN3_ENST00000508946.1_Missense_Mutation_p.S824P|LPHN3_ENST00000507625.1_Missense_Mutation_p.S892P|LPHN3_ENST00000506700.1_Missense_Mutation_p.S824P|LPHN3_ENST00000504896.1_Missense_Mutation_p.S824P|LPHN3_ENST00000511324.1_Missense_Mutation_p.S892P|LPHN3_ENST00000514996.1_Missense_Mutation_p.S824P|LPHN3_ENST00000506720.1_Missense_Mutation_p.S892P|LPHN3_ENST00000508693.1_Missense_Mutation_p.S892P|LPHN3_ENST00000545650.1_Missense_Mutation_p.S824P|LPHN3_ENST00000509896.1_Missense_Mutation_p.S892P|LPHN3_ENST00000506746.1_Missense_Mutation_p.S892P|LPHN3_ENST00000507164.1_Missense_Mutation_p.S892P|LPHN3_ENST00000514591.1_Missense_Mutation_p.S824P|LPHN3_ENST00000514157.1_Missense_Mutation_p.S824P			Q9HAR2	LPHN3_HUMAN	latrophilin 3		GPS.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(21)|lung(73)|ovary(1)|pancreas(1)|prostate(6)|upper_aerodigestive_tract(1)	125						TTGGAGCTACTCCAAGCGTAC	0.373000													6	15					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103368593	103368593	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr7:103368593C>T	ENST00000424685.2	-	7	877	c.718G>A	c.(718-720)Gtc>Atc	p.V240I	RELN_ENST00000343529.5_Missense_Mutation_p.V240I|RELN_ENST00000428762.1_Missense_Mutation_p.V240I			P78509	RELN_HUMAN	reelin	240					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CAGAAGGTGACGGCATTGCCA	0.433000													50	59					0	0	1	0	0
CC2D2A	57545	broad.mit.edu	37	4	15542459	15542459	+	Splice_Site	SNP	G	G	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr4:15542459G>A	ENST00000424120.1	+	17	2257		c.e17-1		CC2D2A_ENST00000413206.1_Splice_Site|CC2D2A_ENST00000503292.1_Splice_Site|CC2D2A_ENST00000513811.1_Splice_Site|CC2D2A_ENST00000389652.5_Splice_Site			Q9P2K1	C2D2A_HUMAN	coiled-coil and C2 domain containing 2A						cell projection organization	cilium|microtubule basal body				NS(1)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(8)|lung(5)|ovary(1)|pancreas(2)|prostate(2)|skin(1)|urinary_tract(2)	32						TCCTTTTGCAGAGCGGAGGTC	0.433000													3	10					0	0	1	0	0
KCNB1	3745	broad.mit.edu	37	20	47991418	47991418	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr20:47991418G>A	ENST00000371741.4	-	2	845	c.679C>T	c.(679-681)Ccc>Tcc	p.P227S		NM_004975.2	NP_004966.1	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 1	227					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(22)|pancreas(2)|prostate(7)|skin(4)|stomach(1)|urinary_tract(1)	53			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			GCCAGCTGGGGGTTGTCTGTG	0.572000													31	41					0	0	1	0	0
PPM1A	5494	broad.mit.edu	37	14	60750068	60750068	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr14:60750068C>T	ENST00000395076.4	+	2	1077	c.647C>T	c.(646-648)tCa>tTa	p.S216L	PPM1A_ENST00000325642.3_Missense_Mutation_p.S289L|PPM1A_ENST00000325658.3_Missense_Mutation_p.S216L|PPM1A_ENST00000529574.1_Missense_Mutation_p.S216L	NM_021003.4	NP_066283.1	P35813	PPM1A_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1A	216					cell cycle arrest|insulin receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway|protein dephosphorylation|Wnt receptor signaling pathway	cytosol|nucleus|protein serine/threonine phosphatase complex	magnesium ion binding|manganese ion binding|protein serine/threonine phosphatase activity|signal transducer activity			cervix(1)|endometrium(1)|large_intestine(8)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	14				OV - Ovarian serous cystadenocarcinoma(108;0.046)		CAGCTTGTCTCACCAGAGCCT	0.443000													55	112					0	0	1	0	0
FAM86DP	692099	broad.mit.edu	37	3	75471179	75471179	+	RNA	SNP	T	T	C			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr3:75471179T>C	ENST00000459803.1	-	0	1962					NR_024241.1																						TTCTCAAACTTTCCTGATCCT	0.552000													19	19					0	0	1	0	0
GPR75-ASB3	100302652	broad.mit.edu	37	2	53897698	53897698	+	Missense_Mutation	SNP	T	T	C			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr2:53897698T>C	ENST00000263634.3	-	10	1633	c.1499A>G	c.(1498-1500)tAt>tGt	p.Y500C	GPR75-ASB3_ENST00000406687.1_Missense_Mutation_p.Y427C|GPR75-ASB3_ENST00000482829.1_5'UTR|GPR75-ASB3_ENST00000352846.3_Missense_Mutation_p.Y538C|GPR75-ASB3_ENST00000394717.2_Missense_Mutation_p.Y427C|ASB3_ENST00000406625.2_Missense_Mutation_p.Y535C	NM_016115.4	NP_057199.1	Q2TAI4	Q2TAI4_HUMAN		535					intracellular signal transduction												AACGTCTTCATAGAGCAAATA	0.388000													11	35					0	0	1	0	0
ATOH1	474	broad.mit.edu	37	4	94750250	94750250	+	Missense_Mutation	SNP	G	G	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr4:94750250G>T	ENST00000306011.3	+	1	209	c.173G>T	c.(172-174)aGc>aTc	p.S58I		NM_005172.1	NP_005163.1	Q92858	ATOH1_HUMAN	atonal homolog 1 (Drosophila)	58					transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	11		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;3.57e-07)		CTCCTGGACAGCACCGACCCA	0.677000													27	47					1.16021e-09	1.19925e-09	1	1	0
POLRMT	5442	broad.mit.edu	37	19	619039	619039	+	Silent	SNP	G	G	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr19:619039G>A	ENST00000588649.2	-	15	3309	c.3225C>T	c.(3223-3225)ggC>ggT	p.G1075G		NM_005035.3	NP_005026.3	O00411	RPOM_HUMAN	polymerase (RNA) mitochondrial (DNA directed)	1075	Mediates interaction with TEFM.				transcription initiation from mitochondrial promoter	mitochondrial nucleoid	DNA binding|DNA-directed RNA polymerase activity|protein binding			cervix(2)|endometrium(3)|large_intestine(1)|lung(9)|ovary(1)|pancreas(2)|prostate(1)|stomach(1)	20		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGACGGGGACGCCCAGGGGTG	0.647000													20	21					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140993238	140993238	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chrX:140993238G>C	ENST00000285879.4	+	4	334	c.48G>C	c.(46-48)caG>caC	p.Q16H	MAGEC1_ENST00000406005.2_5'UTR	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	16							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					GTCTTCTCCAGAGTTCCTCTG	0.552000										HNSCC(15;0.026)			45	48					0	0	1	0	0
LMLN	89782	broad.mit.edu	37	3	197726164	197726164	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr3:197726164C>G	ENST00000330198.4	+	11	1205	c.1183C>G	c.(1183-1185)Cag>Gag	p.Q395E	LMLN_ENST00000482695.1_Missense_Mutation_p.Q343E|LMLN_ENST00000332636.5_Missense_Mutation_p.Q343E|LMLN_ENST00000420910.2_Missense_Mutation_p.Q395E	NM_033029.3	NP_149018.2	Q96KR4	LMLN_HUMAN	leishmanolysin-like (metallopeptidase M8 family)	395					cell adhesion|cell division|mitosis|proteolysis	cytoplasm|membrane	metalloendopeptidase activity|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)	Lung NSC(153;0.132)	Epithelial(36;9.84e-24)|all cancers(36;3.18e-22)|OV - Ovarian serous cystadenocarcinoma(49;5.35e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.111)		TTCTCACACTCAGAATCGAGT	0.388000													17	58					0	0	1	0	0
TLN2	83660	broad.mit.edu	37	15	63128203	63128203	+	Silent	SNP	C	C	G			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr15:63128203C>G	ENST00000561311.1	+	56	7535	c.7305C>G	c.(7303-7305)tcC>tcG	p.S2435S	TLN2_ENST00000306829.6_Silent_p.S2435S|RP11-1069G10.1_ENST00000558404.1_RNA			Q9Y4G6	TLN2_HUMAN	talin 2	2435	I/LWEQ.				cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			NS(3)|breast(6)|central_nervous_system(3)|endometrium(8)|kidney(8)|large_intestine(20)|lung(34)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)	99						TCGCCGCTTCCACGGCTCAGC	0.612000													14	25					0	0	1	0	0
MMP8	4317	broad.mit.edu	37	11	102586120	102586120	+	Silent	SNP	A	A	G			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr11:102586120A>G	ENST00000236826.3	-	7	1049	c.951T>C	c.(949-951)ttT>ttC	p.F317F		NM_002424.2	NP_002415.1	P22894	MMP8_HUMAN	matrix metallopeptidase 8 (neutrophil collagenase)	317	Hemopexin-like 1.				collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(3)|kidney(1)|large_intestine(4)|lung(11)|ovary(4)|skin(6)|stomach(1)|urinary_tract(1)	32	all_cancers(8;0.00092)|all_epithelial(12;0.00389)|Lung NSC(15;0.227)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0555)|Lung(13;0.0828)|LUSC - Lung squamous cell carcinoma(19;0.151)|all cancers(10;0.189)	BRCA - Breast invasive adenocarcinoma(274;0.0141)		ATAGAGAAATAAAATTCATTT	0.383000													18	16					0	0	1	0	0
ASCC2	84164	broad.mit.edu	37	22	30200815	30200815	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr22:30200815C>T	ENST00000397771.2	-	14	1342	c.1165G>A	c.(1165-1167)Gag>Aag	p.E389K	ASCC2_ENST00000542393.1_Missense_Mutation_p.E313K|ASCC2_ENST00000307790.3_Missense_Mutation_p.E389K			Q9H1I8	ASCC2_HUMAN	activating signal cointegrator 1 complex subunit 2	389					regulation of transcription, DNA-dependent|transcription, DNA-dependent					endometrium(3)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	18			OV - Ovarian serous cystadenocarcinoma(5;0.000103)|Epithelial(10;0.0169)|all cancers(5;0.0259)			GTCCGCGTCTCGTCCCTGTGA	0.547000													97	315					0	0	1	0	0
CELA2A	63036	broad.mit.edu	37	1	15789243	15789243	+	Silent	SNP	C	C	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr1:15789243C>T	ENST00000359621.4	+	4	268	c.243C>T	c.(241-243)taC>taT	p.Y81Y		NM_033440.2	NP_254275.1	P08217	CEL2A_HUMAN	chymotrypsin-like elastase family, member 2A	81	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(7)|ovary(2)|prostate(1)	16						CCAGGACCTACCGCGTGGGGC	0.612000													43	81					0	0	1	0	0
MARCH11	441061	broad.mit.edu	37	5	16067768	16067768	+	Missense_Mutation	SNP	T	T	C			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr5:16067768T>C	ENST00000332432.8	-	4	1220	c.1021A>G	c.(1021-1023)Agt>Ggt	p.S341G		NM_001102562.1	NP_001096032.1	A6NNE9	MARHB_HUMAN	membrane-associated ring finger (C3HC4) 11	341						cytoplasmic vesicle membrane|integral to membrane	ligase activity|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(14)|urinary_tract(1)	20						AAAGTCCTACTTGTGGAAGAC	0.473000													28	62					0	0	1	0	0
ZNF608	57507	broad.mit.edu	37	5	123983602	123983602	+	Silent	SNP	T	T	C			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr5:123983602T>C	ENST00000306315.5	-	4	2910	c.2475A>G	c.(2473-2475)aaA>aaG	p.K825K	ZNF608_ENST00000504926.1_Silent_p.K398K	NM_020747.2	NP_065798.2	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	825						intracellular	zinc ion binding			breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(12)|ovary(3)|skin(6)|urinary_tract(1)	46		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		TTCCCGTCTCTTTCCCTTCTT	0.473000													76	174					0	0	1	0	0
DUSP9	1852	broad.mit.edu	37	X	152915679	152915679	+	Silent	SNP	G	G	T	rs139744131	byFrequency	TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chrX:152915679G>T	ENST00000342782.3	+	4	1339	c.1074G>T	c.(1072-1074)ggG>ggT	p.G358G	DUSP9_ENST00000370167.4_Silent_p.G358G			Q99956	DUS9_HUMAN	dual specificity phosphatase 9	358	Tyrosine-protein phosphatase.				inactivation of MAPK activity|JNK cascade	cytosol|endoplasmic reticulum|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(2)|prostate(1)	16	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GCAGTGGGGGGCAGGCATCTG	0.672000													7	117					0.00198382	0.00199309	1	1	0
GDPD4	220032	broad.mit.edu	37	11	76944073	76944073	+	Silent	SNP	G	G	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr11:76944073G>A	ENST00000315938.4	-	13	1636	c.1386C>T	c.(1384-1386)ttC>ttT	p.F462F	GDPD4_ENST00000376217.2_Silent_p.F462F	NM_182833.1	NP_878253.1	Q6W3E5	GDPD4_HUMAN	glycerophosphodiester phosphodiesterase domain containing 4	462					glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|prostate(1)|skin(1)	20						AGCTCACCATGAAGAAGTGAG	0.557000													13	43					0	0	1	0	0
SHROOM3	57619	broad.mit.edu	37	4	77357255	77357255	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr4:77357255C>G	ENST00000296043.6	+	1	1003	c.50C>G	c.(49-51)tCt>tGt	p.S17C		NM_020859.3	NP_065910.3	Q8TF72	SHRM3_HUMAN	shroom family member 3	17					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(29)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	60			Lung(101;0.0903)			ACATTAAACTCTAACACGGCC	0.483000													66	131					0	0	1	0	0
MGLL	11343	broad.mit.edu	37	3	127439916	127439916	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr3:127439916C>G	ENST00000434178.2	-	5	1356	c.460G>C	c.(460-462)Gaa>Caa	p.E154Q	MGLL_ENST00000398101.3_Missense_Mutation_p.E128Q|MGLL_ENST00000453507.2_Missense_Mutation_p.E164Q|MGLL_ENST00000265052.5_Missense_Mutation_p.E164Q|MGLL_ENST00000398104.1_Missense_Mutation_p.E154Q			Q99685	MGLL_HUMAN	monoglyceride lipase	154					arachidonic acid metabolic process|fatty acid biosynthetic process|inflammatory response|platelet activation|regulation of endocannabinoid signaling pathway|regulation of inflammatory response|regulation of sensory perception of pain|triglyceride catabolic process	plasma membrane	acylglycerol lipase activity|carboxylesterase activity|lysophospholipase activity|protein homodimerization activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)	6						GTTGCAGATTCAGGATTGGCA	0.537000													26	85					0	0	1	0	0
RNASE3	6037	broad.mit.edu	37	14	21359944	21359944	+	Silent	SNP	G	G	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr14:21359944G>T	ENST00000304639.3	+	2	157	c.99G>T	c.(97-99)acG>acT	p.T33T		NM_002935.2	NP_002926.2	P12724	ECP_HUMAN	ribonuclease, RNase A family, 3	33					defense response to bacterium|RNA catabolic process	extracellular region|soluble fraction	nucleic acid binding|pancreatic ribonuclease activity			endometrium(1)|large_intestine(1)|lung(6)|ovary(1)	9	all_cancers(95;0.00453)		OV - Ovarian serous cystadenocarcinoma(11;6.3e-09)|Epithelial(56;1.42e-07)|all cancers(55;5.48e-07)	GBM - Glioblastoma multiforme(265;0.0187)	Pranlukast(DB01411)	CACAGTTTACGAGGGCTCAGT	0.507000													47	109					3.70713e-34	4.10842e-34	1	1	0
DIDO1	11083	broad.mit.edu	37	20	61541160	61541160	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr20:61541160G>A	ENST00000266070.4	-	4	1377	c.1052C>T	c.(1051-1053)aCa>aTa	p.T351I	DIDO1_ENST00000370366.1_Missense_Mutation_p.T351I|DIDO1_ENST00000395343.1_Missense_Mutation_p.T351I|DIDO1_ENST00000266071.5_Missense_Mutation_p.T351I|DIDO1_ENST00000395335.2_Missense_Mutation_p.T351I|DIDO1_ENST00000354665.4_Missense_Mutation_p.T351I|DIDO1_ENST00000370371.4_Missense_Mutation_p.T351I|DIDO1_ENST00000370368.1_Missense_Mutation_p.T351I|DIDO1_ENST00000395340.1_Missense_Mutation_p.T351I	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	351					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					TCCTATACTTGTACAATCGGT	0.453000													69	102					0	0	1	0	0
HLA-DMB	3109	broad.mit.edu	37	6	32906580	32906580	+	Missense_Mutation	SNP	G	G	A	rs12176347		TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr6:32906580G>A	ENST00000416244.2	-	2	412	c.218C>T	c.(217-219)gCg>gTg	p.A73V	XXbac-BPG181M17.5_ENST00000429234.1_Missense_Mutation_p.A105V|HLA-DMB_ENST00000418107.2_Missense_Mutation_p.A73V			P28068	DMB_HUMAN	major histocompatibility complex, class II, DM beta	73	Beta-1.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	integral to membrane|late endosome membrane|lysosomal membrane|MHC class II protein complex				breast(1)|cervix(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	13						GAGGACATTCGCCAAGCTATT	0.527000													47	80					0	0	1	0	0
ADAMTS14	140766	broad.mit.edu	37	10	72517796	72517796	+	Missense_Mutation	SNP	G	G	A	rs146237817	byFrequency	TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr10:72517796G>A	ENST00000373208.1	+	20	3025	c.3025G>A	c.(3025-3027)Gag>Aag	p.E1009K	ADAMTS14_ENST00000373207.1_Missense_Mutation_p.E1006K	NM_139155.2	NP_631894.2	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 14	1006	TSP type-1 4.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(15)|ovary(7)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50						CGGGCATTGCGAGGGGGATAG	0.667000													6	79					0	0	1	0	0
LOC101927060	101927060	broad.mit.edu	37	17	45128792	45128792	+	RNA	SNP	G	G	T	rs143713325	by1000genomes	TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr17:45128792G>T	ENST00000575173.1	-	0	418																											AATTCAGGTTGTCAGAATGCA	0.373000													5	71					5.18039e-06	5.2786e-06	1	1	0
ALMS1	7840	broad.mit.edu	37	2	73717138	73717138	+	Silent	SNP	A	A	G			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr2:73717138A>G	ENST00000264448.6	+	10	8160	c.8049A>G	c.(8047-8049)gtA>gtG	p.V2683V	ALMS1_ENST00000409009.1_Silent_p.V2641V	NM_015120.4	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	2683					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				breast(4)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(31)|lung(68)|ovary(4)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	147						CAGAATTAGTAGAACCTGCTT	0.398000													173	126					0	0	1	0	0
PTCHD3	374308	broad.mit.edu	37	10	27688159	27688159	+	Silent	SNP	G	G	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr10:27688159G>A	ENST00000438700.3	-	4	1485	c.1368C>T	c.(1366-1368)gtC>gtT	p.V456V		NM_001034842.3	NP_001030014.2	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	456	SSD.				spermatid development	integral to membrane	hedgehog receptor activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	55						ACATGTCATCGACCCCAACAC	0.358000													18	30					0	0	1	0	0
LGR4	55366	broad.mit.edu	37	11	27398722	27398722	+	Nonsense_Mutation	SNP	G	G	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr11:27398722G>T	ENST00000379214.4	-	12	1535	c.1092C>A	c.(1090-1092)tgC>tgA	p.C364*	LGR4_ENST00000389858.4_Nonsense_Mutation_p.C340*	NM_018490.2	NP_060960.2	Q9BXB1	LGR4_HUMAN	leucine-rich repeat containing G protein-coupled receptor 4	364						integral to membrane|plasma membrane	protein-hormone receptor activity			NS(3)|breast(2)|endometrium(3)|kidney(2)|large_intestine(11)|lung(10)|ovary(1)	32						CCAGAGCATGGCAACCATTAA	0.308000													28	47					5.77227e-19	6.17432e-19	1	1	0
C8orf44	56260	broad.mit.edu	37	8	67590131	67590131	+	Missense_Mutation	SNP	A	A	G			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr8:67590131A>G	ENST00000519561.1	+	2	339	c.188A>G	c.(187-189)aAa>aGa	p.K63R	C8orf44-SGK3_ENST00000520044.1_Intron|C8orf44_ENST00000390159.3_Missense_Mutation_p.K63R|C8orf44-SGK3_ENST00000519289.1_Intron|C8orf44_ENST00000521889.1_Missense_Mutation_p.K63R	NM_019607.2	NP_062553.1	Q96CB5	CH044_HUMAN	chromosome 8 open reading frame 44	63										endometrium(1)|kidney(1)|lung(2)	4	Breast(64;0.186)		Epithelial(68;0.000959)|OV - Ovarian serous cystadenocarcinoma(28;0.00318)|all cancers(69;0.00363)|BRCA - Breast invasive adenocarcinoma(89;0.149)			aggagttcgaaaccagcctgg	0.532000													5	29					0	0	1	0	0
BASP1	10409	broad.mit.edu	37	5	17275799	17275799	+	Silent	SNP	C	C	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr5:17275799C>T	ENST00000322611.3	+	2	734	c.474C>T	c.(472-474)gcC>gcT	p.A158A		NM_001271606.1|NM_006317.3	NP_001258535.1|NP_006308.3	P80723	BASP1_HUMAN	brain abundant, membrane attached signal protein 1	158					glomerular visceral epithelial cell differentiation|negative regulation of transcription, DNA-dependent	cytoplasm|cytoskeleton|growth cone|nuclear speck|plasma membrane	protein domain specific binding|transcription corepressor activity|transcription regulatory region DNA binding			endometrium(1)|lung(8)	9						CAGCTCCTGCCGCCCAGGAGA	0.711000													6	15					0	0	1	0	0
KLF5	688	broad.mit.edu	37	13	73649881	73649881	+	Missense_Mutation	SNP	G	G	T	rs144543104		TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr13:73649881G>T	ENST00000377687.4	+	4	1767	c.1231G>T	c.(1231-1233)Gac>Tac	p.D411Y	KLF5_ENST00000539231.1_Missense_Mutation_p.D320Y	NM_001730.3	NP_001721.2	Q13887	KLF5_HUMAN	Kruppel-like factor 5 (intestinal)	411					transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Prostate(6;0.00187)|Breast(118;0.0735)		GBM - Glioblastoma multiforme(99;0.0011)		GGAAGGCTGCGACTGGAGGTT	0.577000													54	137					9.90819e-18	1.04939e-17	1	1	0
PDP1	54704	broad.mit.edu	37	8	94934630	94934630	+	Missense_Mutation	SNP	A	A	G			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr8:94934630A>G	ENST00000396200.3	+	3	694	c.418A>G	c.(418-420)Aat>Gat	p.N140D	PDP1_ENST00000520728.1_Missense_Mutation_p.N115D|PDP1_ENST00000517764.1_Missense_Mutation_p.N115D|PDP1_ENST00000297598.4_Missense_Mutation_p.N115D	NM_001161779.1	NP_001155251.1	Q9P0J1	PDP1_HUMAN	pyruvate dehyrogenase phosphatase catalytic subunit 1	115					pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix|protein serine/threonine phosphatase complex	[pyruvate dehydrogenase (lipoamide)] phosphatase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(4)|liver(1)|lung(5)|ovary(1)|pancreas(1)|skin(2)	18						ATTTGACAGCAATCAGCTGCC	0.468000													41	117					0	0	1	0	0
ANKRD55	79722	broad.mit.edu	37	5	55407475	55407475	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr5:55407475C>A	ENST00000341048.4	-	10	1251	c.1100G>T	c.(1099-1101)aGg>aTg	p.R367M	ANKRD55_ENST00000434982.2_Missense_Mutation_p.R79M|ANKRD55_ENST00000504958.2_Missense_Mutation_p.R324M|ANKRD55_ENST00000505970.2_5'UTR	NM_024669.2	NP_078945.2	Q3KP44	ANR55_HUMAN	ankyrin repeat domain 55	366										breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(17)|ovary(1)|prostate(1)|skin(2)|stomach(1)	34		Lung NSC(810;8.69e-05)|Prostate(74;0.00634)|Breast(144;0.0334)|Ovarian(174;0.223)				GTATCGGTCCCTGCTGGGATC	0.502000													78	185					1.86864e-30	2.04979e-30	1	1	0
GDPD4	220032	broad.mit.edu	37	11	76944076	76944076	+	Silent	SNP	G	G	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr11:76944076G>A	ENST00000315938.4	-	13	1633	c.1383C>T	c.(1381-1383)ttC>ttT	p.F461F	GDPD4_ENST00000376217.2_Silent_p.F461F	NM_182833.1	NP_878253.1	Q6W3E5	GDPD4_HUMAN	glycerophosphodiester phosphodiesterase domain containing 4	461					glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|prostate(1)|skin(1)	20						TCACCATGAAGAAGTGAGGGT	0.547000													13	43					0	0	1	0	0
ABCA8	10351	broad.mit.edu	37	17	66915581	66915581	+	Missense_Mutation	SNP	A	A	G			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr17:66915581A>G	ENST00000269080.2	-	13	1786	c.1649T>C	c.(1648-1650)aTg>aCg	p.M550T	ABCA8_ENST00000586539.1_Missense_Mutation_p.M550T|ABCA8_ENST00000430352.2_Missense_Mutation_p.M550T	NM_007168.2	NP_009099.1	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 8	550	ABC transporter 1.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(2)|endometrium(9)|kidney(5)|large_intestine(19)|liver(1)|lung(30)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|urinary_tract(4)	83	Breast(10;4.56e-13)					TAGGTCAGCCATTTCTGAAAG	0.368000													19	82					0	0	1	0	0
LAIR1	3903	broad.mit.edu	37	19	54871634	54871634	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr19:54871634G>A	ENST00000391743.3	-	3	636	c.356C>T	c.(355-357)tCa>tTa	p.S119L	LAIR1_ENST00000463489.1_5'UTR|LAIR1_ENST00000474878.1_Intron|LAIR1_ENST00000348231.4_Intron|LAIR1_ENST00000434277.2_Missense_Mutation_p.S136L|LAIR1_ENST00000391742.2_Missense_Mutation_p.S137L|LAIR1_ENST00000313038.6_Missense_Mutation_p.S130L			Q6GTX8	LAIR1_HUMAN	leukocyte-associated immunoglobulin-like receptor 1	137						integral to membrane|plasma membrane	protein binding|receptor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(9)|ovary(4)|prostate(1)|stomach(3)	26	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0573)		CTGACCAGCTGAGGAGCCGGG	0.627000													12	30					0	0	1	0	0
TBC1D12	23232	broad.mit.edu	37	10	96162370	96162370	+	Translation_Start_Site	SNP	G	G	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr10:96162370G>A	ENST00000225235.4	+	0	110					NM_015188.1	NP_056003.1	O60347	TBC12_HUMAN	TBC1 domain family, member 12							intracellular	Rab GTPase activator activity			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|upper_aerodigestive_tract(2)	20		Colorectal(252;0.0429)				CCCACCCCCAGATGGTGGGTC	0.697000													22	33					0	0	1	0	0
NSF	4905	broad.mit.edu	37	17	44827187	44827187	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr17:44827187C>A	ENST00000398238.4	+	18	2064	c.1957C>A	c.(1957-1959)Cag>Aag	p.Q653K	NSF_ENST00000225282.8_Missense_Mutation_p.Q559K|NSF_ENST00000575068.1_Missense_Mutation_p.Q648K	NM_006178.3	NP_006169.2	P46459	NSF_HUMAN	N-ethylmaleimide-sensitive factor	653					protein transport|synaptic transmission	cytosol	ATP binding|metal ion binding			kidney(2)|large_intestine(1)|liver(2)|lung(7)|ovary(1)|upper_aerodigestive_tract(1)	14		Melanoma(429;0.203)	BRCA - Breast invasive adenocarcinoma(9;0.0257)	BRCA - Breast invasive adenocarcinoma(366;0.241)		AGATGTCCTTCAGGAGATGGA	0.448000													29	109					6.00712e-18	6.39372e-18	1	1	0
CD5	921	broad.mit.edu	37	11	60892591	60892591	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr11:60892591C>A	ENST00000347785.3	+	9	1533	c.1367C>A	c.(1366-1368)cCt>cAt	p.P456H		NM_014207.3	NP_055022.2	P06127	CD5_HUMAN	CD5 molecule	456					cell proliferation|cell recognition	integral to plasma membrane	scavenger receptor activity			central_nervous_system(1)|large_intestine(4)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		all_lung(304;5.94e-05)|Lung NSC(402;7.26e-05)		BRCA - Breast invasive adenocarcinoma(625;0.000946)|Lung(977;0.0086)|LUSC - Lung squamous cell carcinoma(625;0.0528)		TACAGCCAACCTCCCAGGAAC	0.617000													22	39					3.10358e-05	3.1475e-05	1	1	0
PASK	23178	broad.mit.edu	37	2	242065894	242065894	+	Silent	SNP	C	C	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr2:242065894C>T	ENST00000403638.3	-	10	2527	c.2436G>A	c.(2434-2436)cgG>cgA	p.R812R	PASK_ENST00000405260.1_Silent_p.R812R|PASK_ENST00000544142.1_Silent_p.R626R|PASK_ENST00000234040.4_Silent_p.R812R|PASK_ENST00000539818.1_Silent_p.R596R|PASK_ENST00000358649.4_Silent_p.R812R	NM_001252124.1	NP_001239053.1	Q96RG2	PASK_HUMAN	PAS domain containing serine/threonine kinase	812					regulation of transcription, DNA-dependent	Golgi apparatus	ATP binding|identical protein binding|protein serine/threonine kinase activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|lung(20)|ovary(4)|prostate(4)|skin(1)|stomach(1)|urinary_tract(2)	53		all_cancers(19;4.46e-39)|all_epithelial(40;1.34e-17)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00481)|Lung NSC(271;0.017)|Ovarian(221;0.0228)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.34e-31)|all cancers(36;1e-28)|OV - Ovarian serous cystadenocarcinoma(60;3.53e-14)|Kidney(56;4.31e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.35e-08)|BRCA - Breast invasive adenocarcinoma(100;5.64e-06)|Lung(119;0.000596)|LUSC - Lung squamous cell carcinoma(224;0.00481)|Colorectal(34;0.014)|COAD - Colon adenocarcinoma(134;0.0968)		TCTCCCGGAACCGTCGGCCTT	0.562000													31	33					0	0	1	0	0
AMPH	273	broad.mit.edu	37	7	38475976	38475976	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr7:38475976C>T	ENST00000356264.2	-	12	1245	c.1030G>A	c.(1030-1032)Gag>Aag	p.E344K	AMPH_ENST00000428293.2_Missense_Mutation_p.E344K|AMPH_ENST00000325590.5_Missense_Mutation_p.E344K	NM_001635.3	NP_001626.1	P49418	AMPH_HUMAN	amphiphysin	344					endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				breast(1)|endometrium(3)|kidney(3)|large_intestine(12)|liver(3)|lung(27)|ovary(3)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)	62						TTCTTCACCTCAGGGACTTCA	0.428000													32	33					0	0	1	0	0
ST6GAL1	6480	broad.mit.edu	37	3	186760727	186760727	+	Missense_Mutation	SNP	G	G	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr3:186760727G>T	ENST00000169298.3	+	4	910	c.236G>T	c.(235-237)gGc>gTc	p.G79V	ST6GAL1_ENST00000448044.1_Missense_Mutation_p.G79V|ST6GAL1_ENST00000457772.2_Intron	NM_173216.2	NP_775323.1	P15907	SIAT1_HUMAN	ST6 beta-galactosamide alpha-2,6-sialyltranferase 1	79					humoral immune response|post-translational protein modification|protein N-linked glycosylation via asparagine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	7	all_cancers(143;2.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;8.53e-19)	GBM - Glioblastoma multiforme(93;0.0939)		CAGACCCTCGGCAGTCTCAGA	0.567000													43	137					9.85913e-13	1.02402e-12	1	1	0
ASPG	374569	broad.mit.edu	37	14	104552113	104552113	+	Silent	SNP	G	G	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr14:104552113G>A	ENST00000551177.1	+	1	98	c.6G>A	c.(4-6)gcG>gcA	p.A2A	ASPG_ENST00000455920.2_Silent_p.A2A|ASPG_ENST00000546892.2_Silent_p.A2A	NM_001080464.2	NP_001073933.2	Q86U10	LPP60_HUMAN	asparaginase homolog (S. cerevisiae)	2					lipid catabolic process		1-alkyl-2-acetylglycerophosphocholine esterase activity|asparaginase activity|lysophospholipase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(1)|skin(1)|urinary_tract(1)	11						CCGGCATGGCGCGCGCGGTGG	0.771000													8	15					0	0	1	0	0
ZRANB3	84083	broad.mit.edu	37	2	136107676	136107676	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr2:136107676C>G	ENST00000401392.1	-	5	681	c.469G>C	c.(469-471)Gat>Cat	p.D157H	ZRANB3_ENST00000536680.1_Missense_Mutation_p.D157H|ZRANB3_ENST00000264159.6_Missense_Mutation_p.D157H			Q5FWF4	ZRAB3_HUMAN	zinc finger, RAN-binding domain containing 3	157	Helicase ATP-binding.					intracellular	ATP binding|DNA binding|endonuclease activity|helicase activity|zinc ion binding			NS(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(10)|upper_aerodigestive_tract(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.135)		TGTGATTCATCCACTATAACT	0.408000													12	14					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54793159	54793159	+	Missense_Mutation	SNP	A	A	C			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr15:54793159A>C	ENST00000545554.1	+	21	5284	c.5284A>C	c.(5284-5286)Atg>Ctg	p.M1762L	UNC13C_ENST00000537900.1_Missense_Mutation_p.M1760L|UNC13C_ENST00000260323.11_Missense_Mutation_p.M1762L			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	1762	MHD1.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		ATCTCACTTAATGAGAAGATT	0.368000													44	75					0	0	1	0	0
PDCD2L	84306	broad.mit.edu	37	19	34895679	34895679	+	Silent	SNP	C	C	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr19:34895679C>T	ENST00000246535.3	+	2	281	c.234C>T	c.(232-234)ttC>ttT	p.F78F	RP11-618P17.4_ENST00000606020.1_Silent_p.F73F	NM_032346.1	NP_115722.1	Q9BRP1	PDD2L_HUMAN	programmed cell death 2-like	78						cytoplasm				breast(2)|kidney(1)|large_intestine(4)|lung(1)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.211)			TGCACGTGTTCGCGTGCGCCT	0.711000													10	10					0	0	1	0	0
NFASC	23114	broad.mit.edu	37	1	204923365	204923365	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr1:204923365C>T	ENST00000367172.4	+	6	593	c.265C>T	c.(265-267)Cgg>Tgg	p.R89W	NFASC_ENST00000360049.4_Missense_Mutation_p.R83W|NFASC_ENST00000339876.6_Missense_Mutation_p.R89W|NFASC_ENST00000367171.4_Missense_Mutation_p.R89W|NFASC_ENST00000401399.1_Missense_Mutation_p.R89W|NFASC_ENST00000338515.6_Missense_Mutation_p.R89W|NFASC_ENST00000404907.1_Missense_Mutation_p.R83W|NFASC_ENST00000367170.4_Missense_Mutation_p.R89W|NFASC_ENST00000404076.1_Missense_Mutation_p.R83W|NFASC_ENST00000513543.1_Missense_Mutation_p.R83W|NFASC_ENST00000367169.4_Missense_Mutation_p.R89W|NFASC_ENST00000338586.6_Missense_Mutation_p.R89W|NFASC_ENST00000403080.1_Missense_Mutation_p.R89W|NFASC_ENST00000539706.1_Missense_Mutation_p.R83W			O94856	NFASC_HUMAN	neurofascin	89	Ig-like C2-type 1.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			CAAGGACCCCCGGGTGTCCAT	0.602000													19	53					0	0	1	0	0
RP11-909M7.3	0	broad.mit.edu	37	14	101436252	101436252	+	RNA	SNP	A	A	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr14:101436252A>T	ENST00000554693.2	+	0	299				SNORD114-13_ENST00000364377.1_RNA																							TATGAGTCATACACATGAACA	0.393000													7	22					0	0	1	0	0
COIL	8161	broad.mit.edu	37	17	55023818	55023818	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr17:55023818G>A	ENST00000240316.4	-	5	1577	c.1543C>T	c.(1543-1545)Ctt>Ttt	p.L515F		NM_004645.2	NP_004636.1	P38432	COIL_HUMAN	coilin	515	2 X 4 AA repeats of S-L-P-A.					Cajal body|nucleolus	protein C-terminus binding			NS(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)|urinary_tract(1)	15	Breast(9;6.15e-08)					AAGGATGAAAGAATTTCTATA	0.328000													47	161					0	0	1	0	0
ZFP37	7539	broad.mit.edu	37	9	115805738	115805738	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr9:115805738C>G	ENST00000374227.3	-	4	1187	c.1160G>C	c.(1159-1161)aGa>aCa	p.R387T	ZFP37_ENST00000553380.1_Missense_Mutation_p.R402T|ZFP37_ENST00000555206.1_Missense_Mutation_p.R388T	NM_001282515.1|NM_001282518.1	NP_001269444.1|NP_001269447.1	Q9Y6Q3	ZFP37_HUMAN	ZFP37 zinc finger protein	387						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	38						TGAGCTGTGTCTGAAGGTTTT	0.413000													41	82					0	0	1	0	0
LDHD	197257	broad.mit.edu	37	16	75149486	75149486	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr16:75149486C>T	ENST00000300051.4	-	2	191	c.145G>A	c.(145-147)Gtg>Atg	p.V49M	LDHD_ENST00000450168.2_Missense_Mutation_p.V49M	NM_153486.3	NP_705690.2	Q86WU2	LDHD_HUMAN	lactate dehydrogenase D	49							D-lactate dehydrogenase (cytochrome) activity|flavin adenine dinucleotide binding|protein binding			endometrium(1)|large_intestine(2)|lung(12)|upper_aerodigestive_tract(1)	16						TCTCGGACCACCGCGGCAGTG	0.647000													7	38					0	0	1	0	0
CNKSR1	10256	broad.mit.edu	37	1	26515960	26515960	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr1:26515960C>G	ENST00000531191.1	+	20	2296	c.1289C>G	c.(1288-1290)tCc>tGc	p.S430C	CNKSR1_ENST00000374253.5_Missense_Mutation_p.S695C|CNKSR1_ENST00000361530.6_Missense_Mutation_p.S688C			Q969H4	CNKR1_HUMAN	connector enhancer of kinase suppressor of Ras 1	695	PH.				Rho protein signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway	cell cortex|cell-cell junction	protein binding, bridging			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(8)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	28		Colorectal(325;3.46e-05)|all_lung(284;0.000116)|Lung NSC(340;0.000154)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;2.72e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00072)|BRCA - Breast invasive adenocarcinoma(304;0.000959)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00823)|READ - Rectum adenocarcinoma(331;0.0649)		TCCCCCCACTCCCTGCCCTCT	0.642000													42	84					0	0	1	0	0
MYOM2	9172	broad.mit.edu	37	8	2044236	2044236	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr8:2044236G>A	ENST00000262113.4	+	18	2416	c.2275G>A	c.(2275-2277)Gag>Aag	p.E759K	MYOM2_ENST00000523438.1_Missense_Mutation_p.E184K	NM_003970.2	NP_003961.2	P54296	MYOM2_HUMAN	myomesin 2	759	Fibronectin type-III 4.				muscle contraction	myosin filament	structural constituent of muscle			autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		AAACTGGCACGAGGTCAATTC	0.493000													23	49					0	0	1	0	0
ZFP37	7539	broad.mit.edu	37	9	115806541	115806541	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr9:115806541C>G	ENST00000374227.3	-	4	384	c.357G>C	c.(355-357)caG>caC	p.Q119H	ZFP37_ENST00000553380.1_Missense_Mutation_p.Q134H|ZFP37_ENST00000555206.1_Missense_Mutation_p.Q120H	NM_001282515.1|NM_001282518.1	NP_001269444.1|NP_001269447.1	Q9Y6Q3	ZFP37_HUMAN	ZFP37 zinc finger protein	119						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	38						CATCATCTTTCTGGACTTCTA	0.353000													26	54					0	0	1	0	0
NLRP2	55655	broad.mit.edu	37	19	55512138	55512138	+	Missense_Mutation	SNP	G	G	C	rs144393067		TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr19:55512138G>C	ENST00000543010.1	+	13	3204	c.3061G>C	c.(3061-3063)Gat>Cat	p.D1021H	NLRP2_ENST00000339757.7_Missense_Mutation_p.D999H|NLRP2_ENST00000427260.2_Missense_Mutation_p.D998H|NLRP2_ENST00000537859.1_Missense_Mutation_p.D999H|NLRP2_ENST00000448584.2_Missense_Mutation_p.D1021H|NLRP2_ENST00000538819.1_Missense_Mutation_p.D997H|NLRP2_ENST00000391721.4_Missense_Mutation_p.D997H|NLRP2_ENST00000263437.6_Missense_Mutation_p.D1018H	NM_001174081.1	NP_001167552.1	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	1021					apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			large_intestine(4)|liver(1)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	11			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		GTTGAAAATCGATGACTTTAA	0.393000													36	53					0	0	1	0	0
LRRFIP2	9209	broad.mit.edu	37	3	37125241	37125241	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr3:37125241C>A	ENST00000421307.1	-	20	1586	c.1164G>T	c.(1162-1164)caG>caT	p.Q388H	LRRFIP2_ENST00000336686.4_Missense_Mutation_p.Q388H|LRRFIP2_ENST00000440230.1_Missense_Mutation_p.Q156H|LRRFIP2_ENST00000421276.2_Missense_Mutation_p.Q156H|LRRFIP2_ENST00000396428.2_Missense_Mutation_p.Q204H|LRRFIP2_ENST00000354379.4_Missense_Mutation_p.Q132H	NM_006309.2	NP_006300.1	Q9Y608	LRRF2_HUMAN	leucine rich repeat (in FLII) interacting protein 2	388					Wnt receptor signaling pathway		LRR domain binding	p.0?(1)		breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(4)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	22						CATTGTCTAACTGTGCATTGG	0.348000													19	74					2.4624e-09	2.53309e-09	1	1	0
ZBTB11	27107	broad.mit.edu	37	3	101390721	101390721	+	Silent	SNP	C	C	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr3:101390721C>T	ENST00000461821.1	-	2	850	c.647G>A	c.(646-648)tGa>tAa	p.*216*	ZBTB11_ENST00000312938.4_Intron			O95625	ZBT11_HUMAN	zinc finger and BTB domain containing 11	0	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(7)|lung(14)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	37						TTGTCTTATTCAATAAGCAGT	0.328000													10	11					0	0	1	0	0
PRSS35	167681	broad.mit.edu	37	6	84234199	84234199	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr6:84234199G>A	ENST00000536636.1	+	3	1384	c.1039G>A	c.(1039-1041)Ggt>Agt	p.G347S	PRSS35_ENST00000369700.3_Missense_Mutation_p.G347S	NM_001170423.1	NP_001163894.1	Q8N3Z0	PRS35_HUMAN	protease, serine, 35	347	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			breast(2)|endometrium(2)|large_intestine(12)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	32		all_cancers(76;0.000113)|Acute lymphoblastic leukemia(125;1.09e-08)|all_hematologic(105;3.12e-05)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0768)		GGGCTCCACCGGTTCGGGGGT	0.512000													52	72					0	0	1	0	0
THSD4	79875	broad.mit.edu	37	15	72030322	72030322	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr15:72030322G>C	ENST00000355327.3	+	11	2016	c.1882G>C	c.(1882-1884)Gaa>Caa	p.E628Q	THSD4_ENST00000357769.4_Missense_Mutation_p.E268Q|THSD4_ENST00000567838.1_3'UTR|THSD4_ENST00000261862.6_Missense_Mutation_p.E628Q			Q6ZMP0	THSD4_HUMAN	thrombospondin, type I, domain containing 4	628						proteinaceous extracellular matrix	metalloendopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(20)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42						TGGGACAACAGAATGTTCCAC	0.612000													20	43					0	0	1	0	0
NBEA	26960	broad.mit.edu	37	13	35731303	35731303	+	Nonsense_Mutation	SNP	G	G	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr13:35731303G>T	ENST00000540320.1	+	21	3274	c.2740G>T	c.(2740-2742)Gaa>Taa	p.E914*	NBEA_ENST00000379939.2_Nonsense_Mutation_p.E914*|NBEA_ENST00000400445.3_Nonsense_Mutation_p.E914*|NBEA_ENST00000310336.4_Nonsense_Mutation_p.E914*			Q8NFP9	NBEA_HUMAN	neurobeachin	914						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		GAAGATTACCGAAATGGTCTA	0.408000													37	76					1.84765e-07	1.89164e-07	1	1	0
RB1CC1	9821	broad.mit.edu	37	8	53568651	53568651	+	Silent	SNP	T	T	C			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr8:53568651T>C	ENST00000025008.5	-	15	4261	c.3738A>G	c.(3736-3738)ctA>ctG	p.L1246L	RB1CC1_ENST00000521611.1_Intron|RB1CC1_ENST00000435644.2_Silent_p.L1246L|RB1CC1_ENST00000539297.1_Silent_p.L1246L	NM_014781.4	NP_055596.3	Q8TDY2	RBCC1_HUMAN	RB1-inducible coiled-coil 1	1246					autophagy|cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding			NS(2)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(19)|ovary(8)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	60		all_cancers(86;0.137)|all_epithelial(80;0.00494)|Lung NSC(129;0.011)|all_lung(136;0.023)				TAAATTCTTTTAGGGCAGTCT	0.328000													30	46					0	0	1	0	0
MAP4K3	8491	broad.mit.edu	37	2	39505628	39505628	+	Splice_Site	SNP	C	C	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr2:39505628C>T	ENST00000263881.3	-	24	2039		c.e24-1		MAP4K3_ENST00000437545.1_Splice_Site|MAP4K3_ENST00000341681.5_Splice_Site|MAP4K3_ENST00000536018.1_Splice_Site	NM_003618.3	NP_003609.2	Q8IVH8	M4K3_HUMAN	mitogen-activated protein kinase kinase kinase kinase 3						JNK cascade		ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	44		all_hematologic(82;0.211)				AAGTACTGATCTGAAATAAAA	0.264000													31	27					0	0	1	0	0
GNL2	29889	broad.mit.edu	37	1	38032516	38032516	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr1:38032516C>G	ENST00000373062.3	-	16	2234	c.2136G>C	c.(2134-2136)aaG>aaC	p.K712N	GNL2_ENST00000462812.1_5'UTR	NM_013285.2	NP_037417.1	Q13823	NOG2_HUMAN	guanine nucleotide binding protein-like 2 (nucleolar)	712					ribosome biogenesis	nucleolus	GTP binding|GTPase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(8)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	30		Myeloproliferative disorder(586;0.0393)				CATTGGTCTTCTTTTTGTTCC	0.388000													52	108					0	0	1	0	0
ANXA13	312	broad.mit.edu	37	8	124748071	124748071	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr8:124748071C>T	ENST00000262219.6	-	2	129	c.62G>A	c.(61-63)gGg>gAg	p.G21E	ANXA13_ENST00000419625.1_Intron	NM_001003954.1	NP_001003954.1	P27216	ANX13_HUMAN	annexin A13	0					cell differentiation	plasma membrane	calcium ion binding|calcium-dependent phospholipid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(2)	25	Lung NSC(37;2.06e-11)|Ovarian(258;0.00579)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00288)			TTGGGAGTCCCCTTTAGGCAA	0.517000													34	87					0	0	1	0	0
GTF2B	2959	broad.mit.edu	37	1	89323052	89323052	+	Silent	SNP	G	G	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr1:89323052G>A	ENST00000370500.5	-	6	772	c.654C>T	c.(652-654)ttC>ttT	p.F218F	GTF2B_ENST00000494819.1_5'UTR	NM_001514.5	NP_001505.1	Q00403	TF2B_HUMAN	general transcription factor IIB	218					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	nucleoplasm	thyroid hormone receptor binding|translation initiation factor activity|zinc ion binding			endometrium(2)|large_intestine(2)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	10		Lung NSC(277;0.123)		all cancers(265;0.0131)|Epithelial(280;0.0255)		GGTTGGAACAGAACCTGGACA	0.433000													26	50					0	0	1	0	0
SLCO5A1	81796	broad.mit.edu	37	8	70588853	70588853	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr8:70588853G>A	ENST00000260126.4	-	9	2786	c.2080C>T	c.(2080-2082)Cga>Tga	p.R694*	SLCO5A1_ENST00000524945.1_Intron|SLCO5A1_ENST00000530307.1_Nonsense_Mutation_p.R639*	NM_030958.2	NP_112220.2	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family, member 5A1							integral to membrane|plasma membrane	transporter activity	p.R694R(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(24)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	53	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			CCAAGTGTTCGCAACAAAACA	0.418000													20	48					0	0	1	0	0
AP3D1	8943	broad.mit.edu	37	19	2110148	2110148	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr19:2110148G>A	ENST00000355272.6	-	28	3457	c.3251C>T	c.(3250-3252)tCc>tTc	p.S1084F	AP3D1_ENST00000356926.4_Missense_Mutation_p.S981F|AP3D1_ENST00000350812.6_Missense_Mutation_p.S853F|AP3D1_ENST00000345016.5_Missense_Mutation_p.S1022F	NM_001261826.1	NP_001248755.1	O14617	AP3D1_HUMAN	adaptor-related protein complex 3, delta 1 subunit	1022					eye pigment biosynthetic process|intracellular protein transport|regulation of sequestering of zinc ion|vesicle-mediated transport	endosome membrane|Golgi membrane|membrane coat	binding|protein transporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(23)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCAATGAAGGACAGGGTCCC	0.632000													21	42					0	0	1	0	0
FBN2	2201	broad.mit.edu	37	5	127674667	127674667	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr5:127674667C>T	ENST00000508053.1	-	32	4404	c.3430G>A	c.(3430-3432)Gaa>Aaa	p.E1144K	FBN2_ENST00000508989.1_Missense_Mutation_p.E1111K|FBN2_ENST00000507835.1_5'UTR|FBN2_ENST00000262464.4_Missense_Mutation_p.E1144K			P35556	FBN2_HUMAN	fibrillin 2	1144	EGF-like 16; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent	p.E1144K(1)		NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TCATAGCCTTCGAAGCACTCG	0.507000													32	84					0	0	1	0	0
PCDH8	5100	broad.mit.edu	37	13	53421499	53421499	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr13:53421499G>A	ENST00000377942.3	-	1	1276	c.1073C>T	c.(1072-1074)cCg>cTg	p.P358L	PCDH8_ENST00000338862.4_Missense_Mutation_p.P358L	NM_002590.3	NP_002581.2	O95206	PCDH8_HUMAN	protocadherin 8	358					cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(23)|ovary(1)|skin(1)|urinary_tract(1)	36		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		GGCGGCCAGCGGGGTGATGGC	0.761000													8	14					0	0	1	0	0
GAS2L2	246176	broad.mit.edu	37	17	34073278	34073278	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr17:34073278C>T	ENST00000254466.6	-	6	1265	c.1238G>A	c.(1237-1239)aGg>aAg	p.R413K	GAS2L2_ENST00000587565.1_Missense_Mutation_p.R397K	NM_139285.3	NP_644814.1	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	413					cell cycle arrest	cytoplasm|cytoskeleton				central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	35		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		AATCCTTCCCCTGGGGAGTTC	0.597000													154	150					0	0	1	0	0
DTX1	1840	broad.mit.edu	37	12	113515459	113515459	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr12:113515459C>T	ENST00000257600.3	+	2	993	c.490C>T	c.(490-492)Cgc>Tgc	p.R164C		NM_004416.2	NP_004407.2	Q86Y01	DTX1_HUMAN	deltex homolog 1 (Drosophila)	164	WWE 2.				negative regulation of neuron differentiation|Notch signaling pathway|regulation of Notch signaling pathway|transcription from RNA polymerase II promoter	cytoplasm|nucleus	Notch binding|SH3 domain binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(11)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	32						CCGCCAGAcgcgccggcgccg	0.677000													6	22					0	0	1	0	0
DPP6	1804	broad.mit.edu	37	7	154564587	154564587	+	Silent	SNP	C	C	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr7:154564587C>T	ENST00000404039.1	+	10	1466	c.879C>T	c.(877-879)caC>caT	p.H293H	DPP6_ENST00000332007.3_Silent_p.H295H|DPP6_ENST00000427557.1_Silent_p.H250H|DPP6_ENST00000377770.3_Silent_p.H357H	NM_001039350.1|NM_001936.3|NM_130797.2	NP_001034439.1|NP_001927.3|NP_570629.2	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6	357					cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			NS(3)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(35)|pancreas(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	71	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			TTTCCCTACACGTTATTGGCT	0.453000													17	13					0	0	1	0	0
KRTAP19-2	337969	broad.mit.edu	37	21	31859546	31859546	+	Nonsense_Mutation	SNP	G	G	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr21:31859546G>T	ENST00000334055.3	-	1	209	c.122C>A	c.(121-123)tCa>tAa	p.S41*		NM_181608.1	NP_853639.1	Q3LHN2	KR192_HUMAN	keratin associated protein 19-2	41						intermediate filament				endometrium(1)|kidney(1)|large_intestine(2)|lung(1)	5						TCTGTAGCATGATGGGCAGCA	0.473000													78	138					2.08937e-45	2.32754e-45	1	1	0
PARD6A	50855	broad.mit.edu	37	16	67695399	67695399	+	Silent	SNP	G	G	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr16:67695399G>A	ENST00000458121.2	+	2	196	c.105G>A	c.(103-105)tcG>tcA	p.S35S	PARD6A_ENST00000602551.1_Silent_p.S35S|PARD6A_ENST00000219255.3_Silent_p.S35S	NM_001037281.1|NM_016948.2	NP_001032358.1|NP_058644.1	Q9NPB6	PAR6A_HUMAN	par-6 family cell polarity regulator alpha	35	Interaction with PRKCI and PRKCZ.|OPR.				cell cycle|cell division|cell-cell junction maintenance|tight junction assembly|viral reproduction	cytosol|nucleus|ruffle|tight junction	GTP-dependent protein binding|Rho GTPase binding|transcription factor binding			central_nervous_system(1)|large_intestine(1)|lung(1)|ovary(1)|urinary_tract(2)	6		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.047)|all cancers(182;0.228)		CTCGCGCTTCGGTGAGCGGCT	0.657000													38	87					0	0	1	0	0
RRP1B	23076	broad.mit.edu	37	21	45106729	45106729	+	Missense_Mutation	SNP	G	G	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr21:45106729G>T	ENST00000340648.4	+	12	1171	c.1054G>T	c.(1054-1056)Gat>Tat	p.D352Y		NM_015056.2	NP_055871.1	Q14684	RRP1B_HUMAN	ribosomal RNA processing 1B	352					rRNA processing	cytosol|nucleolus|preribosome, small subunit precursor	protein binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(3)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(1)	21				STAD - Stomach adenocarcinoma(101;0.178)		CATTTCTGCTGATGAAGATGA	0.428000													35	84					2.47316e-13	2.5938e-13	1	1	0
ZNF423	23090	broad.mit.edu	37	16	49671231	49671231	+	Missense_Mutation	SNP	T	T	A	rs114911915	by1000genomes	TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr16:49671231T>A	ENST00000561648.1	-	4	1885	c.1832A>T	c.(1831-1833)gAg>gTg	p.E611V	ZNF423_ENST00000535559.1_Missense_Mutation_p.E494V|ZNF423_ENST00000567169.1_Missense_Mutation_p.E494V|ZNF423_ENST00000563137.2_Missense_Mutation_p.E551V|ZNF423_ENST00000262383.2_Missense_Mutation_p.E611V|ZNF423_ENST00000562871.1_Missense_Mutation_p.E551V|ZNF423_ENST00000562520.1_Missense_Mutation_p.E551V	NM_001271620.1	NP_001258549.1	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	611					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(16)|lung(47)|ovary(1)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	89		all_cancers(37;0.0155)				GGAAGACACCTCCACATCGGA	0.547000													46	60					0	0	1	0	0
GDPD4	220032	broad.mit.edu	37	11	76944087	76944087	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr11:76944087G>A	ENST00000315938.4	-	13	1622	c.1372C>T	c.(1372-1374)Cac>Tac	p.H458Y	GDPD4_ENST00000376217.2_Missense_Mutation_p.H458Y	NM_182833.1	NP_878253.1	Q6W3E5	GDPD4_HUMAN	glycerophosphodiester phosphodiesterase domain containing 4	458					glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|prostate(1)|skin(1)	20						AAGTGAGGGTGATCAAGCTGA	0.537000													18	43					0	0	1	0	0
MAST3	23031	broad.mit.edu	37	19	18234408	18234408	+	Silent	SNP	G	G	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr19:18234408G>A	ENST00000262811.6	+	7	489	c.489G>A	c.(487-489)ggG>ggA	p.G163G	MAST3_ENST00000608648.1_3'UTR	NM_015016.1	NP_055831.1	O60307	MAST3_HUMAN	microtubule associated serine/threonine kinase 3								ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(6)|ovary(4)|pancreas(1)|stomach(1)	31						GTGCAACGGGGACCTTCGACA	0.602000													5	10					0	0	1	0	0
HERC1	8925	broad.mit.edu	37	15	63927026	63927026	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr15:63927026C>T	ENST00000443617.2	-	66	12563	c.12476G>A	c.(12475-12477)gGg>gAg	p.G4159E		NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	4159					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						GTCACCATTCCCAAAGGTGAA	0.448000													14	18					0	0	1	0	0
ICAM3	3385	broad.mit.edu	37	19	10445321	10445321	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr19:10445321G>C	ENST00000589261.1	-	5	1376	c.844C>G	c.(844-846)Caa>Gaa	p.Q282E	ICAM3_ENST00000160262.5_Missense_Mutation_p.Q359E			P32942	ICAM3_HUMAN	intercellular adhesion molecule 3	359	Ig-like C2-type 3.				cell-cell adhesion|regulation of immune response	integral to plasma membrane	integrin binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(7)|ovary(1)|upper_aerodigestive_tract(2)	13			OV - Ovarian serous cystadenocarcinoma(20;6.13e-09)|Epithelial(33;9.69e-06)|all cancers(31;2.05e-05)			AGCTGAAGTTGAGCTGGCTGC	0.632000													32	67					0	0	1	0	0
SMARCD2	6603	broad.mit.edu	37	17	61910950	61910950	+	Silent	SNP	G	G	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr17:61910950G>A	ENST00000448276.2	-	10	1579	c.1314C>T	c.(1312-1314)gtC>gtT	p.V438V	SMARCD2_ENST00000323347.10_Silent_p.V390V|SMARCD2_ENST00000225742.9_Silent_p.V363V	NM_001098426.1	NP_001091896.1	Q92925	SMRD2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2	438					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	SWI/SNF complex	protein binding|transcription coactivator activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(1)	8						GGCCCACCTTGACATCAAGGG	0.577000													40	121					0	0	1	0	0
BAI2	576	broad.mit.edu	37	1	32204223	32204223	+	Silent	SNP	C	C	T	rs140870509		TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr1:32204223C>T	ENST00000373658.3	-	17	2951	c.2610G>A	c.(2608-2610)acG>acA	p.T870T	BAI2_ENST00000527361.1_Silent_p.T870T|BAI2_ENST00000398542.1_Silent_p.T803T|BAI2_ENST00000440175.2_Silent_p.T512T|BAI2_ENST00000257070.4_Silent_p.T870T|BAI2_ENST00000398556.3_Silent_p.T818T|BAI2_ENST00000373655.2_Silent_p.T870T|BAI2_ENST00000398538.1_Silent_p.T858T|BAI2_ENST00000398547.1_Silent_p.T803T	NM_001703.2	NP_001694.2	O60241	BAI2_HUMAN	brain-specific angiogenesis inhibitor 2	870					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity	p.T870T(1)		breast(5)|central_nervous_system(2)|endometrium(1)|large_intestine(7)|liver(2)|lung(24)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	55		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0606)|all_neural(195;0.0837)|Breast(348;0.174)		STAD - Stomach adenocarcinoma(196;0.0557)		AATGGGGATCCGTGGTCCCCT	0.632000													8	13					0	0	1	0	0
RNF212	285498	broad.mit.edu	37	4	1107304	1107304	+	Translation_Start_Site	SNP	A	A	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr4:1107304A>T	ENST00000382968.5	-	0	46				RNF212_ENST00000505730.1_5'UTR|RNF212_ENST00000433731.2_De_novo_Start_OutOfFrame|RNF212_ENST00000333673.5_De_novo_Start_OutOfFrame	NM_001131034.3|NM_194439.4	NP_001124506.1|NP_919420.1	Q495C1	RN212_HUMAN	ring finger protein 212								zinc ion binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|prostate(1)|skin(1)	10			OV - Ovarian serous cystadenocarcinoma(23;0.0179)	UCEC - Uterine corpus endometrioid carcinoma (64;0.151)		AGCCCACGCAAGGTTGGGACC	0.736000													10	17					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1267503	1267503	+	Silent	SNP	G	G	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr11:1267503G>A	ENST00000447027.1	+	31	9460	c.9402G>A	c.(9400-9402)acG>acA	p.T3134T	MUC5B_ENST00000529681.1_Silent_p.T3131T|RP11-532E4.2_ENST00000532061.2_RNA			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	3131	17 X approximate tandem repeats, Ser/Thr- rich.|7 X Cys-rich subdomain repeats.|Thr-rich.			Missing (in Ref. 6; AAB61398).	cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding	p.T3110T(1)		cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CTCCGGGGACGACCTGGATCC	0.657000													58	134					0	0	1	0	0
PPP1R21	129285	broad.mit.edu	37	2	48698230	48698230	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr2:48698230C>T	ENST00000294952.8	+	10	1059	c.902C>T	c.(901-903)tCa>tTa	p.S301L	PPP1R21_ENST00000281394.4_Missense_Mutation_p.S301L|PPP1R21_ENST00000449090.2_Missense_Mutation_p.S301L	NM_001135629.2	NP_001129101.1	Q6ZMI0	KLRAQ_HUMAN	protein phosphatase 1, regulatory subunit 21	301										endometrium(2)|kidney(4)|lung(9)	15						GTTTAGTTCTCACAATACCTT	0.363000													31	29					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140995384	140995384	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chrX:140995384C>T	ENST00000285879.4	+	4	2480	c.2194C>T	c.(2194-2196)Cag>Tag	p.Q732*	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	732							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					GTTTCCTCCTCAGGGGGAGGA	0.542000										HNSCC(15;0.026)			100	84					0	0	1	0	0
ADCY2	108	broad.mit.edu	37	5	7695949	7695949	+	Silent	SNP	C	C	G			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr5:7695949C>G	ENST00000338316.4	+	6	1043	c.954C>G	c.(952-954)ctC>ctG	p.L318L	ADCY2_ENST00000537121.1_Silent_p.L138L	NM_020546.2	NP_065433.2	Q08462	ADCY2_HUMAN	adenylate cyclase 2 (brain)	318					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(56)|ovary(8)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	119						TGAATGAGCTCTTTGGAAAGT	0.433000													14	33					0	0	1	0	0
ATG7	10533	broad.mit.edu	37	3	11340868	11340868	+	Silent	SNP	T	T	C			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr3:11340868T>C	ENST00000354449.3	+	3	218	c.193T>C	c.(193-195)Ttg>Ctg	p.L65L	ATG7_ENST00000469654.2_3'UTR|ATG7_ENST00000446450.2_Silent_p.L65L|ATG7_ENST00000354956.5_Silent_p.L65L	NM_006395.2	NP_006386.1	O95352	ATG7_HUMAN	autophagy related 7	65					autophagy|cellular membrane fusion|positive regulation of protein modification process|protein lipidation|protein transport	cytoplasm	APG12 activating enzyme activity|protein homodimerization activity|ubiquitin activating enzyme activity			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(14)|prostate(1)|skin(2)|urinary_tract(1)	34						TCGCTTAACATTGGAGTTCAG	0.393000													50	147					0	0	1	0	0
UCHL1	7345	broad.mit.edu	37	4	41263746	41263746	+	Silent	SNP	C	C	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr4:41263746C>T	ENST00000284440.4	+	5	484	c.340C>T	c.(340-342)Ctg>Ttg	p.L114L	UCHL1_ENST00000512788.1_Silent_p.L114L|UCHL1_ENST00000508768.1_Silent_p.L114L|UCHL1_ENST00000504818.1_3'UTR|UCHL1_ENST00000503431.1_Silent_p.L114L	NM_004181.4	NP_004172.2	P09936	UCHL1_HUMAN	ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)	114					cell death|negative regulation of MAP kinase activity|protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus|plasma membrane	alpha-2A adrenergic receptor binding|cysteine-type endopeptidase activity|ligase activity|omega peptidase activity|ubiquitin binding|ubiquitin thiolesterase activity			central_nervous_system(1)|endometrium(2)|large_intestine(3)|skin(2)	8						TGGATCAGTTCTGAAACAGTT	0.343000													18	41					0	0	1	0	0
TWISTNB	221830	broad.mit.edu	37	7	19738064	19738064	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr7:19738064C>T	ENST00000222567.5	-	4	962	c.892G>A	c.(892-894)Gac>Aac	p.D298N		NM_001002926.1	NP_001002926.1	Q3B726	RPA43_HUMAN	TWIST neighbor	298	Lys-rich.					microtubule cytoskeleton|nucleolus	DNA-directed RNA polymerase activity			kidney(1)|large_intestine(3)|lung(13)|ovary(1)|prostate(2)	20						CCACTGGAGTCACTGCCTTGG	0.423000													208	207					0	0	1	0	0
SAFB	6294	broad.mit.edu	37	19	5668195	5668195	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr19:5668195G>A	ENST00000292123.5	+	21	2748	c.2641G>A	c.(2641-2643)Ggg>Agg	p.G881R	SAFB_ENST00000592224.1_Missense_Mutation_p.G882R|SAFB_ENST00000433404.1_Missense_Mutation_p.G713R|SAFB_ENST00000588852.1_Missense_Mutation_p.G883R|SAFB_ENST00000538656.1_Missense_Mutation_p.G725R|SAFB_ENST00000454510.1_Missense_Mutation_p.G814R	NM_001201338.1|NM_001201339.1|NM_002967.3	NP_001188267.1|NP_001188268.1|NP_002958.2	Q15424	SAFB1_HUMAN	scaffold attachment factor B	881	Gly-rich.|Interaction with SAFB2.				chromatin organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	double-stranded DNA binding|nucleotide binding|protein binding|RNA binding			breast(3)|central_nervous_system(1)|endometrium(5)|large_intestine(4)|liver(1)|lung(6)|ovary(2)|skin(1)	23				UCEC - Uterine corpus endometrioid carcinoma (162;0.000222)		TGCCCCAGGCGGGGCCTCCCG	0.682000													46	78					0	0	1	0	0
LIPF	8513	broad.mit.edu	37	10	90427424	90427424	+	Silent	SNP	G	G	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr10:90427424G>A	ENST00000394375.3	+	4	347	c.234G>A	c.(232-234)aaG>aaA	p.K78K	LIPF_ENST00000355843.2_Silent_p.K78K|LIPF_ENST00000608620.1_Silent_p.K68K|LIPF_ENST00000238983.4_Silent_p.K68K	NM_001198829.1	NP_001185758.1	P07098	LIPG_HUMAN	lipase, gastric	68					lipid catabolic process|triglyceride metabolic process	extracellular region	lipid binding|triglyceride lipase activity			NS(1)|cervix(1)|kidney(1)|large_intestine(4)|lung(6)	13		Colorectal(252;0.0161)		Colorectal(12;3.91e-05)|COAD - Colon adenocarcinoma(12;5.43e-05)		CTTATGGGAAGAAAAATTCAG	0.348000													25	55					0	0	1	0	0
ECE2	9718	broad.mit.edu	37	3	183995773	183995773	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr3:183995773C>G	ENST00000402825.3	+	5	893	c.893C>G	c.(892-894)tCt>tGt	p.S298C	EIF2B5_ENST00000444495.1_Intron|ECE2_ENST00000357474.5_Missense_Mutation_p.S226C|ECE2_ENST00000404464.3_Missense_Mutation_p.S180C|ECE2_ENST00000359140.4_Missense_Mutation_p.S151C	NM_014693.3	NP_055508.3	O60344	ECE2_HUMAN	endothelin converting enzyme 2	298	Endothelin-converting enzyme 2 region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(13)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(4)	49	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TTCTACCTATCTTGCCTACAG	0.562000													40	115					0	0	1	0	0
FAM9B	171483	broad.mit.edu	37	X	8997436	8997436	+	Missense_Mutation	SNP	G	G	A	rs12839241		TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chrX:8997436G>A	ENST00000362066.3	-	5	613	c.425C>T	c.(424-426)tCt>tTt	p.S142F	FAM9B_ENST00000327220.5_Missense_Mutation_p.S102F|FAM9B_ENST00000428477.1_Missense_Mutation_p.S102F			Q8IZU0	FAM9B_HUMAN	family with sequence similarity 9, member B	102						nucleus				breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(2)|urinary_tract(1)	11		Hepatocellular(5;0.219)				CAACTTCAGAGAATGTATATA	0.368000													12	36					0	0	1	0	0
DMBX1	127343	broad.mit.edu	37	1	46976774	46976774	+	Silent	SNP	C	C	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr1:46976774C>A	ENST00000371956.4	+	3	531	c.516C>A	c.(514-516)ggC>ggA	p.G172G	DMBX1_ENST00000360032.3_Silent_p.G167G	NM_147192.2	NP_671725.1	Q8NFW5	DMBX1_HUMAN	diencephalon/mesencephalon homeobox 1	172					brain development|developmental growth|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(3)|lung(6)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	Acute lymphoblastic leukemia(166;0.155)					GTCTGCCTGGCAGCGACCCCC	0.662000													33	114					1.36161e-19	1.46374e-19	1	1	0
FARSB	10056	broad.mit.edu	37	2	223436667	223436667	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr2:223436667G>A	ENST00000281828.6	-	17	1956	c.1693C>T	c.(1693-1695)Cat>Tat	p.H565Y	FARSB_ENST00000536361.1_Missense_Mutation_p.H466Y	NM_005687.3	NP_005678.3	Q9NSD9	SYFB_HUMAN	phenylalanyl-tRNA synthetase, beta subunit	565					phenylalanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|magnesium ion binding|phenylalanine-tRNA ligase activity|RNA binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(5)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	24		Renal(207;0.0183)		Epithelial(121;3.47e-10)|all cancers(144;1.86e-07)|LUSC - Lung squamous cell carcinoma(224;0.00871)|Lung(261;0.011)	L-Phenylalanine(DB00120)	ACGTCAGGATGAAGGACCCCA	0.488000													21	17					0	0	1	0	0
HSPB11	51668	broad.mit.edu	37	1	54405716	54405716	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr1:54405716C>T	ENST00000194214.5	-	2	429	c.40G>A	c.(40-42)Gaa>Aaa	p.E14K	HSPB11_ENST00000371377.3_Missense_Mutation_p.E14K|HSPB11_ENST00000371378.2_Missense_Mutation_p.E14K|HSPB11_ENST00000371376.1_Missense_Mutation_p.E14K	NM_016126.2	NP_057210.2	Q9Y547	HSB11_HUMAN	heat shock protein family B (small), member 11	14					cell adhesion|response to stress			p.E14K(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(1)|urinary_tract(1)	9						AAAATCACTTCGGACCCTTCA	0.328000													14	31					0	0	1	0	0
GRB10	2887	broad.mit.edu	37	7	50663213	50663213	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr7:50663213C>A	ENST00000403097.1	-	17	2321	c.1541G>T	c.(1540-1542)cGt>cTt	p.R514L	GRB10_ENST00000398812.2_Missense_Mutation_p.R520L|GRB10_ENST00000406641.1_Missense_Mutation_p.R462L|GRB10_ENST00000407526.1_Missense_Mutation_p.R462L|GRB10_ENST00000402497.1_Missense_Mutation_p.R462L|GRB10_ENST00000398810.2_Missense_Mutation_p.R462L|GRB10_ENST00000357271.5_Missense_Mutation_p.R474L|GRB10_ENST00000401949.1_Missense_Mutation_p.R520L|GRB10_ENST00000402578.1_Missense_Mutation_p.R462L|GRB10_ENST00000439599.1_Missense_Mutation_p.R514L|GRB10_ENST00000335866.3_Missense_Mutation_p.R462L			Q13322	GRB10_HUMAN	growth factor receptor-bound protein 10	520	SH2.				insulin receptor signaling pathway|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway	cytosol|plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity	p.R520H(1)		NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(19)|ovary(3)|skin(3)|upper_aerodigestive_tract(2)	41	Glioma(55;0.08)|all_neural(89;0.245)					CTGGCTGTCACGGAGGAGAAA	0.383000									Russell-Silver syndrome				137	152					6.95862e-65	7.7922e-65	1	1	0
MUC17	140453	broad.mit.edu	37	7	100681563	100681563	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr7:100681563C>T	ENST00000306151.4	+	3	6930	c.6866C>T	c.(6865-6867)aCg>aTg	p.T2289M		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	2289	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity	p.T2289M(1)		NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					GTCAGCCACACGCTGGTGGCC	0.478000													292	342					0	0	1	0	0
ZNF862	643641	broad.mit.edu	37	7	149558887	149558887	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr7:149558887G>A	ENST00000223210.4	+	7	2883	c.2638G>A	c.(2638-2640)Gag>Aag	p.E880K	RP4-751H13.7_ENST00000608963.1_RNA	NM_001099220.1	NP_001092690.1	O60290	ZN862_HUMAN	zinc finger protein 862	880					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|nucleic acid binding|protein dimerization activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)|skin(1)	34						CGTGGCACTGGAGAGCCTCCG	0.602000													39	37					0	0	1	0	0
ARID1A	8289	broad.mit.edu	37	1	27107085	27107102	+	In_Frame_Del	DEL	GCGGGCTGCCCGCGCGCT	GCGGGCTGCCCGCGCGCT	-			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr1:27107085_27107102delGCGGGCTGCCCGCGCGCT	ENST00000324856.7	+	20	7067_7084	c.6696_6713delGCGGGCTGCCCGCGCGCT	c.(6694-6714)cggcgggctgcccgcgcgctg>cgg	p.RAARAL2233del	ARID1A_ENST00000374152.2_In_Frame_Del_p.RAARAL1850del|ARID1A_ENST00000540690.1_In_Frame_Del_p.RAARAL561del|ARID1A_ENST00000457599.2_In_Frame_Del_p.RAARAL2016del	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	2233					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding	p.A2235fs*32(1)|p.L2238fs*40(1)|p.M2231fs*32(1)	ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		ACATGATGCGGCGGGCTGCCCGCGCGCTGCTTGCCTTG	0.573			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								27	123	---	---	---	---					
NOTCH2	4853	broad.mit.edu	37	1	120612003	120612004	+	Frame_Shift_Del	DEL	GG	GG	-			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr1:120612003_120612004delGG	ENST00000256646.2	-	1	236_237	c.17_18delCC	c.(16-18)cccfs	p.P6fs		NM_024408.3	NP_077719.2	Q04721	NOTC2_HUMAN	notch 2	6					anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity	p.P6fs*27(2)		breast(4)|central_nervous_system(6)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(9)|kidney(9)|large_intestine(19)|liver(1)|lung(57)|ovary(4)|pancreas(1)|prostate(7)|skin(24)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	158	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		ACAGCAGAGCGGGGCGCAGGGC	0.762			"""N, F, Mis"""		"""marginal zone lymphoma, DLBCL"""				Alagille Syndrome				7	32	---	---	---	---					
ZFP36L2	678	broad.mit.edu	37	2	43452831	43452832	+	Frame_Shift_Ins	INS	-	-	C			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr2:43452831_43452832insC	ENST00000282388.3	-	2	404_405	c.111_112insG	c.(109-114)gggacgfs	p.T38fs	THADA_ENST00000330266.7_Intron	NM_006887.4	NP_008818.3	P47974	TISD_HUMAN	ZFP36 ring finger protein-like 2	38					cell proliferation	nucleus	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	15		Acute lymphoblastic leukemia(82;0.00323)|all_hematologic(82;0.00824)				GCCACAGGCGTCCCCACCGCCT	0.663													21	19	---	---	---	---					
ARIH2	10425	broad.mit.edu	37	3	49005998	49005998	+	Frame_Shift_Del	DEL	C	C	-			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr3:49005998delC	ENST00000356401.4	+	7	909	c.570delC	c.(568-570)ctcfs	p.L190fs	ARIH2_ENST00000449376.1_Frame_Shift_Del_p.L190fs|ARIH2_ENST00000490095.1_3'UTR	NM_006321.2	NP_006312.1	O95376	ARI2_HUMAN	ariadne RBR E3 ubiquitin protein ligase 2	190					developmental cell growth|hemopoietic stem cell proliferation|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(3)|ovary(1)|skin(1)	13				BRCA - Breast invasive adenocarcinoma(193;9.42e-05)|Kidney(197;0.00258)|KIRC - Kidney renal clear cell carcinoma(197;0.00269)		ACTGTCCACTCCGTACACCAG	0.502													151	155	---	---	---	---					
ADH1C	126	broad.mit.edu	37	4	100265826	100265827	+	RNA	INS	-	-	AACTC	rs138852664	by1000genomes	TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr4:100265826_100265827insAACTC	ENST00000515683.1	-	0	919				ADH1C_ENST00000510055.1_RNA	NM_000669.3	NP_000660.1	P00326	ADH1G_HUMAN	alcohol dehydrogenase 1C (class I), gamma polypeptide						ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|zinc ion binding								OV - Ovarian serous cystadenocarcinoma(123;1.08e-07)	Fomepizole(DB01213)|NADH(DB00157)	TACATTTTCTTAACAAGTTTTT	0.297													5	2	---	---	---	---					
TRERF1	55809	broad.mit.edu	37	6	42196333	42196333	+	Frame_Shift_Del	DEL	T	T	-			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr6:42196333delT	ENST00000541110.1	-	18	3981	c.3413delA	c.(3412-3414)aagfs	p.K1138fs	TRERF1_ENST00000372917.4_Frame_Shift_Del_p.K1047fs|TRERF1_ENST00000372922.4_Frame_Shift_Del_p.K1118fs|TRERF1_ENST00000340840.2_Frame_Shift_Del_p.K1047fs|TRERF1_ENST00000354325.2_Frame_Shift_Del_p.K1035fs			Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	1118	Interacts with CREBBP.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(7)|kidney(1)|large_intestine(12)|lung(13)|ovary(3)|pancreas(1)|skin(3)|urinary_tract(2)	45	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CTTCTGAGCCTTTTGCCTCTG	0.542													8	554	---	---	---	---					
GIGYF1	64599	broad.mit.edu	37	7	100283947	100283948	+	Frame_Shift_Ins	INS	-	-	C			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr7:100283947_100283948insC	ENST00000275732.5	-	8	2012_2013	c.803_804insG	c.(802-804)ggafs	p.G268fs	GIGYF1_ENST00000471340.2_Intron	NM_022574.4	NP_072096.2	O75420	PERQ1_HUMAN	GRB10 interacting GYF protein 1	268	Poly-Gly.									central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	23	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					TGCCTCCCCCTCCCCGCCCCTC	0.644													7	186	---	---	---	---					
PLEKHA7	144100	broad.mit.edu	37	11	16838371	16838390	+	Frame_Shift_Del	DEL	CCTTGGAGAATCCCCCAGCG	CCTTGGAGAATCCCCCAGCG	-	rs142792914		TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr11:16838371_16838390delCCTTGGAGAATCCCCCAGCG	ENST00000355661.3	-	11	1833_1852	c.1823_1842delCGCTGGGGGATTCTCCAAGG	c.(1822-1842)tcgctgggggattctccaaggfs	p.SLGDSPR608fs	PLEKHA7_ENST00000448080.2_Frame_Shift_Del_p.SLGDSPR608fs|PLEKHA7_ENST00000531066.1_Frame_Shift_Del_p.SLGDSPR608fs|PLEKHA7_ENST00000532079.1_Intron			Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A member 7	608	Interaction with CTNND1.				epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	37						CCCGTGCCCTCCTTGGAGAATCCCCCAGCGAGATGTCCAC	0.641													9	72	---	---	---	---					
MBD6	114785	broad.mit.edu	37	12	57920934	57920934	+	Frame_Shift_Del	DEL	C	C	-			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr12:57920934delC	ENST00000355673.3	+	7	2362	c.2006delC	c.(2005-2007)gccfs	p.A669fs	MBD6_ENST00000431731.2_Frame_Shift_Del_p.A669fs	NM_052897.3	NP_443129.3	Q96DN6	MBD6_HUMAN	methyl-CpG binding domain protein 6	669	Pro-rich.					chromosome|nucleus	chromatin binding|DNA binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(8)|lung(8)|ovary(1)|urinary_tract(1)	31						CCACTTTCAGCCCCCCCTACC	0.642													28	24	---	---	---	---					
SLC9A7P1	121456	broad.mit.edu	37	12	98848832	98848832	+	RNA	DEL	C	C	-			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr12:98848832delC	ENST00000554295.1	-	0	2091					NR_033801.1																						ACTGTGCTGTCCCCATAGGTC	0.527													7	17	---	---	---	---					
FLT3	2322	broad.mit.edu	37	13	28609758	28609759	+	Frame_Shift_Ins	INS	-	-	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr13:28609758_28609759insT	ENST00000380982.4	-	12	1551_1552	c.1470_1471insA	c.(1468-1473)aaagtgfs	p.V491fs	FLT3_ENST00000537084.1_Frame_Shift_Ins_p.V491fs|FLT3_ENST00000241453.7_Frame_Shift_Ins_p.V491fs			P36888	FLT3_HUMAN	fms-related tyrosine kinase 3	491					positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity	p.V491L(2)		NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(12329)|kidney(2)|large_intestine(8)|lung(30)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	12390	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	TGTCCAAACACTTTTCTGTTAG	0.426			"""Mis, O"""		"""AML, ALL"""								60	126	---	---	---	---					
FOXA1	3169	broad.mit.edu	37	14	38060758	38060762	+	Frame_Shift_Del	DEL	GCTCC	GCTCC	-			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr14:38060758_38060762delGCTCC	ENST00000250448.2	-	2	1288_1292	c.1227_1231delGGAGC	c.(1225-1233)tcggagcagfs	p.EQ410fs	FOXA1_ENST00000540786.1_Frame_Shift_Del_p.EQ377fs|FOXA1_ENST00000545425.2_5'UTR	NM_004496.3	NP_004487.2	P55317	FOXA1_HUMAN	forkhead box A1	410					chromatin remodeling|embryo development|epithelial cell maturation involved in prostate gland development|epithelial tube branching involved in lung morphogenesis|epithelial-mesenchymal signaling involved in prostate gland development|glucose homeostasis|lung epithelial cell differentiation|negative regulation of survival gene product expression|neuron fate specification|pattern specification process|positive regulation of estrogen receptor signaling pathway|positive regulation of mitotic cell cycle|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|prostate gland epithelium morphogenesis|prostate gland stromal morphogenesis|response to estradiol stimulus|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(1)|endometrium(1)|large_intestine(2)|lung(3)|prostate(12)	19	Breast(36;0.0954)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;5.41e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.0454)|LUSC - Lung squamous cell carcinoma(13;0.0917)|all cancers(34;0.0925)|BRCA - Breast invasive adenocarcinoma(188;0.239)	GBM - Glioblastoma multiforme(112;0.0222)		TTATGCTGCTGCTCCGAGGAGGACA	0.600													11	49	---	---	---	---					
SERF2	10169	broad.mit.edu	37	15	44092712	44092714	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr15:44092712_44092714delAAG	ENST00000594896.1	+	3	169_171	c.54_56delAAG	c.(52-57)gaaaga>gaa	p.R20del	HYPK_ENST00000498605.1_3'UTR|HYPK_ENST00000442995.2_5'UTR|SERF2_ENST00000600633.1_5'UTR|HYPK_ENST00000406925.1_5'UTR			P84101	SERF2_HUMAN	small EDRK-rich factor 2	0						cytosol|nucleus				lung(1)	1		all_cancers(109;7.57e-15)|all_epithelial(112;3.51e-12)|Lung NSC(122;4.72e-08)|all_lung(180;4.9e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;7.81e-07)		CTGGAGCAGAAAGAAGGTGTGGC	0.606											OREG0003941	type=REGULATORY REGION|Gene=BX647438|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	4	5	---	---	---	---					
ITGAE	3682	broad.mit.edu	37	17	3661102	3661104	+	In_Frame_Del	DEL	GAC	GAC	-			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr17:3661102_3661104delGAC	ENST00000263087.4	-	9	1014_1016	c.916_918delGTC	c.(916-918)gtcdel	p.V306del		NM_002208.4	NP_002199.3	P38570	ITAE_HUMAN	integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)	306	VWFA.				cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			NS(1)|breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	41				UCEC - Uterine corpus endometrioid carcinoma (3;0.0813)		GCACCACCATGACCTTGGATGCC	0.532													13	300	---	---	---	---					
HAUS8	93323	broad.mit.edu	37	19	17160706	17160707	+	Frame_Shift_Del	DEL	GA	GA	-			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr19:17160706_17160707delGA	ENST00000593360.1	-	10	3044_3045	c.1026_1027delTC	c.(1024-1029)tctcgtfs	p.R343fs	HAUS8_ENST00000448593.2_Frame_Shift_Del_p.R403fs|HAUS8_ENST00000253669.5_Frame_Shift_Del_p.R404fs			Q9BT25	HAUS8_HUMAN	HAUS augmin-like complex, subunit 8	404					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle pole				endometrium(1)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)	12						CTCCCTGAACGAGAGAGAGAGG	0.495													7	260	---	---	---	---					
ZNF223	7766	broad.mit.edu	37	19	44564985	44564985	+	Frame_Shift_Del	DEL	G	G	-			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr19:44564985delG	ENST00000591793.1	+	6	639	c.556delG	c.(556-558)gggfs	p.G186fs	ZNF223_ENST00000585552.1_Frame_Shift_Del_p.G76fs|ZNF223_ENST00000434772.3_Frame_Shift_Del_p.G76fs			Q9UK11	ZN223_HUMAN	zinc finger protein 223	76					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	18		Prostate(69;0.0352)				CCAAAGGGAAGGGAATTCAGG	0.433													46	146	---	---	---	---					
SSX9	280660	broad.mit.edu	37	X	48162915	48162916	+	RNA	INS	-	-	T			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chrX:48162915_48162916insT	ENST00000608568.1	-	0	367					NR_073393.1															breast(1)|endometrium(1)|kidney(2)|lung(2)|prostate(1)|stomach(1)	8						tctgcatgcaattttttttcac	0.351													14	10	---	---	---	---