Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
DDX4	54514	broad.mit.edu	37	5	55088541	55088541	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr5:55088541G>A	ENST00000505374.1	+	17	1467	c.1375G>A	c.(1375-1377)Gaa>Aaa	p.E459K	DDX4_ENST00000514278.2_Missense_Mutation_p.E439K|DDX4_ENST00000354991.5_Missense_Mutation_p.E425K|DDX4_ENST00000511853.1_Missense_Mutation_p.E310K|DDX4_ENST00000353507.5_Missense_Mutation_p.E425K	NM_024415.2	NP_077726.1	Q9NQI0	DDX4_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 4	459	Helicase ATP-binding.				multicellular organismal development|sperm motility	perinuclear region of cytoplasm|pi-body|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(8)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)	24		Lung NSC(810;6.93e-05)|all_neural(839;0.00409)|Prostate(74;0.0107)|Breast(144;0.0544)|Ovarian(174;0.223)				TTTTGGTCCAGAAATGAAGAA	0.378000													16	24					0	0	1	0	0
CACNG3	10368	broad.mit.edu	37	16	24268126	24268126	+	Silent	SNP	C	C	T			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr16:24268126C>T	ENST00000005284.3	+	1	1253	c.51C>T	c.(49-51)gcC>gcT	p.A17A		NM_006539.3	NP_006530.1	O60359	CCG3_HUMAN	calcium channel, voltage-dependent, gamma subunit 3	17					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(1)|endometrium(4)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|prostate(4)|skin(2)	40				GBM - Glioblastoma multiforme(48;0.0809)		CTGTAGGAGCCTTTGCCGCTT	0.473000													26	1106					0	0	1	0	0
OR52B6	340980	broad.mit.edu	37	11	5602231	5602231	+	Missense_Mutation	SNP	A	A	C			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr11:5602231A>C	ENST00000345043.2	+	1	125	c.125A>C	c.(124-126)cAa>cCa	p.Q42P	HBG2_ENST00000380259.2_Intron|AC015691.13_ENST00000394793.2_RNA	NM_001005162.2	NP_001005162.2	Q8NGF0	O52B6_HUMAN	olfactory receptor, family 52, subfamily B, member 6	42					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|lung(7)|ovary(1)|prostate(1)	12		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;3.56e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGGCTGGAGCAACTACATATC	0.502000													7	12					0	0	1	0	0
NOD1	10392	broad.mit.edu	37	7	30485764	30485764	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr7:30485764C>G	ENST00000222823.4	-	9	2971	c.2446G>C	c.(2446-2448)Gag>Cag	p.E816Q		NM_006092.2	NP_006083.1	Q9Y239	NOD1_HUMAN	nucleotide-binding oligomerization domain containing 1	816					activation of MAPK activity|detection of bacterium|induction of apoptosis|inflammatory response|innate immune response|interleukin-8 biosynthetic process|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of dendritic cell antigen processing and presentation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	basolateral plasma membrane|cytosol	ATP binding|CARD domain binding|caspase activator activity|peptidoglycan binding|protein homodimerization activity			breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(2)|prostate(1)|skin(2)	39						CACCCAACCTCAGAGATTGAT	0.488000													29	398					0	0	1	0	0
ZNF860	344787	broad.mit.edu	37	3	32031962	32031962	+	Missense_Mutation	SNP	A	A	G	rs1808125	by1000genomes	TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr3:32031962A>G	ENST00000360311.4	+	2	1940	c.1391A>G	c.(1390-1392)cAt>cGt	p.H464R		NM_001137674.2	NP_001131146.2	A6NHJ4	ZN860_HUMAN	zinc finger protein 860	464					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|lung(4)|ovary(1)	8						AAGACCTTCCATCACAATTCA	0.418000													4	110					0	0	1	0	0
CYP3A7	1551	broad.mit.edu	37	7	99308460	99308460	+	Nonsense_Mutation	SNP	A	A	C			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr7:99308460A>C	ENST00000336374.2	-	10	923	c.921T>G	c.(919-921)taT>taG	p.Y307*		NM_000765.3	NP_000756.2	P24462	CP3A7_HUMAN	cytochrome P450, family 3, subfamily A, polypeptide 7	307					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			autonomic_ganglia(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	32	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)					TCGTGGTTTCATAGCCAGCAA	0.413000													24	40					0	0	1	0	0
IL18R1	8809	broad.mit.edu	37	2	103013325	103013325	+	Silent	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr2:103013325G>A	ENST00000409599.1	+	12	1961	c.1605G>A	c.(1603-1605)ttG>ttA	p.L535L	IL18R1_ENST00000233957.1_Silent_p.L535L			Q13478	IL18R_HUMAN	interleukin 18 receptor 1	535					innate immune response	integral to membrane|plasma membrane	interleukin-1 receptor activity			breast(1)|endometrium(3)|large_intestine(11)|lung(12)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	34						CGGAAGTCTTGCCTGTTCTTT	0.413000													9	21					0	0	1	0	0
COL6A6	131873	broad.mit.edu	37	3	130285707	130285707	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr3:130285707G>A	ENST00000358511.6	+	4	1475	c.1444G>A	c.(1444-1446)Gac>Aac	p.D482N	COL6A6_ENST00000453409.2_Missense_Mutation_p.D482N	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	482	Nonhelical region.|VWFA 3.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						TCAGTATGCTGACAGCTGGGA	0.478000													27	124					0	0	1	0	0
CAV2	858	broad.mit.edu	37	7	116139888	116139888	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr7:116139888C>G	ENST00000222693.4	+	1	445	c.53C>G	c.(52-54)tCc>tGc	p.S18C	CAV2_ENST00000343213.2_Missense_Mutation_p.S18C|CAV2_ENST00000462876.1_Intron|CAV2_ENST00000393480.2_Missense_Mutation_p.S18C	NM_001206747.1|NM_001206748.1|NM_001233.4	NP_001193676.1|NP_001193677.1|NP_001224.1	P51636	CAV2_HUMAN	caveolin 2	18					caveola assembly|endoplasmic reticulum organization|mitochondrion organization|negative regulation of endothelial cell proliferation|positive regulation of dopamine receptor signaling pathway|regulation of mitosis|skeletal muscle fiber development|vesicle docking|vesicle fusion	caveola|extrinsic to internal side of plasma membrane|Golgi membrane|integral to plasma membrane|membrane fraction|nucleus|perinuclear region of cytoplasm|transport vesicle	D1 dopamine receptor binding|protein homodimerization activity			large_intestine(1)|lung(1)|skin(1)	3	all_epithelial(6;1.53e-06)|Lung NSC(10;0.00592)|all_lung(10;0.00642)		STAD - Stomach adenocarcinoma(10;0.00878)			GACGACGACTCCTACAGCCAC	0.682000													2	2					0	0	1	0	0
IFNAR2	3455	broad.mit.edu	37	21	34621017	34621017	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr21:34621017C>G	ENST00000404220.3	+	6	727	c.398C>G	c.(397-399)tCt>tGt	p.S133C	AP000295.9_ENST00000433395.2_Missense_Mutation_p.L41V|IFNAR2_ENST00000382264.3_Missense_Mutation_p.S133C|IFNAR2_ENST00000413881.1_Missense_Mutation_p.S61C|IFNAR2_ENST00000342101.3_Missense_Mutation_p.S133C|IFNAR2_ENST00000382241.3_Missense_Mutation_p.S133C|IFNAR2_ENST00000342136.4_Missense_Mutation_p.S133C			P48551	INAR2_HUMAN	interferon (alpha, beta and omega) receptor 2	133					JAK-STAT cascade|regulation of type I interferon-mediated signaling pathway|response to interferon-alpha|response to virus|type I interferon-mediated signaling pathway	extracellular region|extracellular space|integral to plasma membrane	protein kinase binding|type I interferon binding|type I interferon receptor activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)|skin(1)	11					Interferon Alfa-2a, Recombinant(DB00034)|Interferon Alfa-2b, Recombinant(DB00105)|Interferon alfa-n1(DB00011)|Interferon alfa-n3(DB00018)|Interferon alfacon-1(DB00069)|Interferon beta-1b(DB00068)|Peginterferon alfa-2a(DB00008)|Peginterferon alfa-2b(DB00022)	tGCACAGTGTCTTTTGAACCA	0.373000													17	80					0	0	1	0	0
KIAA0368	23392	broad.mit.edu	37	9	114206748	114206748	+	Missense_Mutation	SNP	A	A	C			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr9:114206748A>C	ENST00000259335.4	-	5	713	c.714T>G	c.(712-714)aaT>aaG	p.N238K	KIAA0368_ENST00000338205.5_Missense_Mutation_p.N60K	NM_001080398.1	NP_001073867.1			KIAA0368											NS(2)|breast(3)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(23)|prostate(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	65						TTATACGTTTATTCAGATGGA	0.388000													9	35					0	0	1	0	0
MYO5A	4644	broad.mit.edu	37	15	52632551	52632551	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr15:52632551C>T	ENST00000399231.3	-	32	4324	c.4081G>A	c.(4081-4083)Gag>Aag	p.E1361K	MYO5A_ENST00000399233.2_Missense_Mutation_p.E1358K|MYO5A_ENST00000553916.1_Missense_Mutation_p.E1334K|MYO5A_ENST00000358212.6_Missense_Mutation_p.E1361K|MYO5A_ENST00000356338.6_Missense_Mutation_p.E1334K	NM_000259.3	NP_000250	Q9Y4I1	MYO5A_HUMAN	myosin VA (heavy chain 12, myoxin)	1361					actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(7)|large_intestine(12)|lung(19)|ovary(3)|skin(3)|stomach(1)	57				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		GCCTCATTCTCATGGCTCCTC	0.632000													55	411					0	0	1	0	0
GPAT2	150763	broad.mit.edu	37	2	96698049	96698049	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr2:96698049C>T	ENST00000434632.1	-	3	518	c.59G>A	c.(58-60)cGa>cAa	p.R20Q	GPAT2_ENST00000359548.4_Missense_Mutation_p.R20Q|GPAT2_ENST00000453542.1_Missense_Mutation_p.R20Q|GPAT2_ENST00000377137.3_Missense_Mutation_p.R20Q			Q6NUI2	GPAT2_HUMAN	glycerol-3-phosphate acyltransferase 2, mitochondrial	20					glycerol-3-phosphate metabolic process|phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity			NS(1)|breast(1)|cervix(1)|endometrium(4)|large_intestine(1)|lung(5)|skin(3)	16						CATTACCTCTCGGCCACTGGG	0.572000													6	44					0	0	1	0	0
BCL2L14	79370	broad.mit.edu	37	12	12232321	12232321	+	Missense_Mutation	SNP	G	G	A	rs142096906	byFrequency	TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr12:12232321G>A	ENST00000266434.4	+	2	277	c.82G>A	c.(82-84)Gcc>Acc	p.A28T	BCL2L14_ENST00000396369.1_Missense_Mutation_p.A28T|BCL2L14_ENST00000586576.1_Missense_Mutation_p.A61T|BCL2L14_ENST00000308721.5_Missense_Mutation_p.A28T|BCL2L14_ENST00000396367.1_Missense_Mutation_p.A28T|BCL2L14_ENST00000589718.1_Missense_Mutation_p.A28T	NM_030766.1	NP_110393.1	Q9BZR8	B2L14_HUMAN	BCL2-like 14 (apoptosis facilitator)	28					apoptosis|regulation of apoptosis	cytosol|endomembrane system|intracellular organelle|membrane	protein binding			large_intestine(1)|lung(2)|skin(3)	6		Prostate(47;0.0872)		BRCA - Breast invasive adenocarcinoma(232;0.154)		CAAAATCCTCGCCTACTACAC	0.488000													22	29					0	0	1	0	0
MTA1	9112	broad.mit.edu	37	14	105936438	105936438	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr14:105936438G>C	ENST00000331320.7	+	21	2248	c.2034G>C	c.(2032-2034)aaG>aaC	p.K678N	MTA1_ENST00000435036.2_Missense_Mutation_p.K218N|MTA1_ENST00000406191.1_Missense_Mutation_p.K666N|MTA1_ENST00000405646.1_Missense_Mutation_p.K661N|RP11-521B24.5_ENST00000552675.1_RNA	NM_001203258.1|NM_004689.3	NP_001190187.1|NP_004680.2	Q13330	MTA1_HUMAN	metastasis associated 1	678					signal transduction	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|stomach(1)	14		all_cancers(154;0.0293)|all_epithelial(191;0.128)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00897)|Epithelial(46;0.026)	Epithelial(152;0.19)		CGGAAACCAAGCGTGCTGCCC	0.716000													21	48					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195512118	195512118	+	Silent	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr3:195512118G>A	ENST00000463781.3	-	2	6792	c.6333C>T	c.(6331-6333)acC>acT	p.T2111T	MUC4_ENST00000346145.4_Intron|MUC4_ENST00000349607.4_Intron|MUC4_ENST00000475231.1_Silent_p.T2111T	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	880	EGF-like 2.				cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		CATGAAGAGCGGTGGCGTGAC	0.572000													3	5					0	0	1	0	0
KIF11	3832	broad.mit.edu	37	10	94405356	94405356	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr10:94405356C>G	ENST00000260731.3	+	18	2594	c.2504C>G	c.(2503-2505)tCt>tGt	p.S835C		NM_004523.3	NP_004514.2	P52732	KIF11_HUMAN	kinesin family member 11	835					blood coagulation|cell division|microtubule-based movement|spindle assembly involved in mitosis	chromatin remodeling complex|cytosol|kinesin complex|microtubule|spindle pole	ATP binding|microtubule motor activity|protein kinase binding			breast(1)|endometrium(5)|kidney(2)|large_intestine(9)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						CAGTGGGTATCTTCCTTAAAT	0.343000													14	20					0	0	1	0	0
BMP2K	55589	broad.mit.edu	37	4	79832995	79832995	+	Silent	SNP	C	C	T			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr4:79832995C>T	ENST00000335016.5	+	16	3460	c.3294C>T	c.(3292-3294)gtC>gtT	p.V1098V	PAQR3_ENST00000295462.3_Intron	NM_198892.1	NP_942595.1	Q9NSY1	BMP2K_HUMAN	BMP2 inducible kinase	1098						nucleus	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|endometrium(4)|large_intestine(2)|lung(3)|prostate(1)|urinary_tract(1)	13						ACAATACTGTCCTGCCAGGGC	0.517000													5	46					0	0	1	0	0
C5	727	broad.mit.edu	37	9	123742496	123742496	+	Missense_Mutation	SNP	G	G	T			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr9:123742496G>T	ENST00000223642.1	-	28	3552	c.3523C>A	c.(3523-3525)Ctg>Atg	p.L1175M		NM_001735.2	NP_001726.2	P01031	CO5_HUMAN	complement component 5	1175					activation of MAPK activity|chemotaxis|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|G-protein coupled receptor protein signaling pathway|inflammatory response|negative regulation of macrophage chemotaxis|positive regulation of chemokine secretion|positive regulation vascular endothelial growth factor production	extracellular space|membrane attack complex	chemokine activity|endopeptidase inhibitor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(14)|lung(5)|ovary(2)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	46				OV - Ovarian serous cystadenocarcinoma(323;4.98e-53)|GBM - Glioblastoma multiforme(294;0.0242)	Eculizumab(DB01257)	TTTTCAAGCAGAAAGTTGTCA	0.408000													7	50					1.04858e-14	1.15065e-14	1	1	0
AOAH	313	broad.mit.edu	37	7	36657936	36657936	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr7:36657936C>G	ENST00000431169.1	-	10	1018	c.718G>C	c.(718-720)Gat>Cat	p.D240H	AOAH_ENST00000535891.1_Missense_Mutation_p.D208H|AOAH_ENST00000258749.5_Missense_Mutation_p.D240H	NM_001177506.1	NP_001170977.1	P28039	AOAH_HUMAN	acyloxyacyl hydrolase (neutrophil)	240					inflammatory response|lipid metabolic process	extracellular region	acyloxyacyl hydrolase activity|lipoprotein lipase activity			NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(2)|large_intestine(3)|lung(21)|prostate(5)|skin(1)|stomach(1)|urinary_tract(3)	41						GGAACTCCATCTTTTGGATCG	0.308000													10	71					0	0	1	0	0
PCDHGA9	56107	broad.mit.edu	37	5	140784367	140784367	+	Silent	SNP	C	C	T			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr5:140784367C>T	ENST00000573521.1	+	1	1848	c.1848C>T	c.(1846-1848)ctC>ctT	p.L616L	PCDHGA3_ENST00000253812.6_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA5_ENST00000518069.1_Intron	NM_018921.2|NM_032089.1	NP_061744.1|NP_114478.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCCAGGGCTCTTCTCGGTGG	0.597000													21	20					0	0	1	0	0
GNPNAT1	64841	broad.mit.edu	37	14	53251332	53251332	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr14:53251332G>C	ENST00000216410.3	-	2	224	c.37C>G	c.(37-39)Cta>Gta	p.L13V	GNPNAT1_ENST00000554230.1_Intron	NM_198066.3	NP_932332.1	Q96EK6	GNA1_HUMAN	glucosamine-phosphate N-acetyltransferase 1	13					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol|endosome membrane|Golgi membrane	glucosamine 6-phosphate N-acetyltransferase activity			liver(1)|lung(1)|prostate(1)|skin(1)	4	Breast(41;0.176)					TCTTTGAGTAGACTTGGGTCA	0.363000													13	18					0	0	1	0	0
NHLRC1	378884	broad.mit.edu	37	6	18122765	18122765	+	Nonsense_Mutation	SNP	C	C	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr6:18122765C>A	ENST00000340650.3	-	1	86	c.73G>T	c.(73-75)Gag>Tag	p.E25*		NM_198586.2	NP_940988.2	Q6VVB1	NHLC1_HUMAN	NHL repeat containing 1	25					proteasomal ubiquitin-dependent protein catabolic process|protein polyubiquitination	endoplasmic reticulum|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|kidney(1)|large_intestine(3)|lung(3)|skin(1)|urinary_tract(2)	11	Ovarian(93;0.016)|Breast(50;0.0245)	all_hematologic(90;0.165)	all cancers(50;0.0451)|Epithelial(50;0.0493)			ACCTTGCACTCGAGCAGGCTG	0.711000													22	40					9.39395e-14	1.0218e-13	1	1	0
SGSM2	9905	broad.mit.edu	37	17	2279473	2279473	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr17:2279473G>A	ENST00000268989.3	+	19	2704	c.2527G>A	c.(2527-2529)Gac>Aac	p.D843N	SGSM2_ENST00000574563.1_Missense_Mutation_p.D798N|SGSM2_ENST00000426855.2_Missense_Mutation_p.D798N|RP1-59D14.5_ENST00000574290.1_RNA	NM_014853.2	NP_055668.2	O43147	SGSM2_HUMAN	small G protein signaling modulator 2	798	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			biliary_tract(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(2)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	20				Colorectal(2;5.15e-05)|READ - Rectum adenocarcinoma(2;0.000115)		GCACCGCATAGACAAGGATGT	0.607000													15	76					0	0	1	0	0
TEX2	55852	broad.mit.edu	37	17	62230483	62230483	+	Missense_Mutation	SNP	T	T	G			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr17:62230483T>G	ENST00000258991.3	-	10	3067	c.2983A>C	c.(2983-2985)Atg>Ctg	p.M995L	TEX2_ENST00000584379.1_Missense_Mutation_p.M988L|TEX2_ENST00000583097.1_Missense_Mutation_p.M988L|TEX2_ENST00000581812.1_5'UTR			Q8IWB9	TEX2_HUMAN	testis expressed 2	988					signal transduction|sphingolipid metabolic process	integral to membrane				breast(3)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(15)|ovary(1)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(8;1.33e-10)	READ - Rectum adenocarcinoma(1115;0.0689)		ACAAACCTCATAATCTTACTT	0.383000													6	31					0	0	1	0	0
ZNF761	388561	broad.mit.edu	37	19	53959137	53959137	+	RNA	SNP	G	G	T			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr19:53959137G>T	ENST00000454407.1	+	0	1829							Q86XN6	ZN761_HUMAN	zinc finger protein 761						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	30				GBM - Glioblastoma multiforme(134;0.00786)		CATCGTAGACGTCATACTGGA	0.393000													4	123					0.184627	0.189205	1	1	0
ADAMTS6	11174	broad.mit.edu	37	5	64756014	64756014	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr5:64756014G>C	ENST00000536360.1	-	4	1427	c.614C>G	c.(613-615)tCt>tGt	p.S205C				Q9UKP5	ATS6_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 6	205					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|pancreas(1)|prostate(1)|skin(3)	18		Lung NSC(167;2.44e-06)|Prostate(74;0.014)|Ovarian(174;0.0549)|Breast(144;0.111)|Colorectal(97;0.235)		Lung(70;0.00942)		CCCACAATGAGAGTGATCATA	0.408000													24	29					0	0	1	0	0
PDCD6IP	10015	broad.mit.edu	37	3	33870428	33870428	+	Silent	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr3:33870428G>A	ENST00000307296.3	+	7	1178	c.801G>A	c.(799-801)caG>caA	p.Q267Q	PDCD6IP_ENST00000457054.2_Silent_p.Q272Q			Q8WUM4	PDC6I_HUMAN	programmed cell death 6 interacting protein	267	BRO1.|Interaction with CHMP4A, CHMP4B and CHMP4C.|Interaction with EIAV p9.				apoptosis|cell cycle|cell division|interspecies interaction between organisms|protein transport	cytosol|melanosome|microtubule organizing center	calcium-dependent protein binding			central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(6)|ovary(2)|skin(1)|stomach(1)	23						CAAAACAGCAGAAGAAATTTG	0.388000													13	43					0	0	1	0	0
PROX1	5629	broad.mit.edu	37	1	214184960	214184960	+	Missense_Mutation	SNP	A	A	C			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr1:214184960A>C	ENST00000366958.4	+	4	2538	c.1930A>C	c.(1930-1932)Aac>Cac	p.N644H	PROX1_ENST00000261454.4_Missense_Mutation_p.N644H|PROX1_ENST00000498508.2_Missense_Mutation_p.N644H|PROX1_ENST00000435016.1_Missense_Mutation_p.N644H	NM_001270616.1	NP_001257545.1	Q92786	PROX1_HUMAN	prospero homeobox 1	644	Prospero-like.				aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of S phase of mitotic cell cycle|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(3)|prostate(2)|skin(4)	47				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)		TCAAGCCATCAACGATGGGGT	0.443000													64	8					0	0	1	0	0
DNM3	26052	broad.mit.edu	37	1	171890908	171890908	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr1:171890908C>T	ENST00000358155.4	+	2	358	c.182C>T	c.(181-183)tCg>tTg	p.S61L	DNM3_ENST00000520906.1_Missense_Mutation_p.S61L|DNM3_ENST00000367731.1_Missense_Mutation_p.S61L|DNM3_ENST00000367733.2_Missense_Mutation_p.S61L|DNM3_ENST00000355305.5_Missense_Mutation_p.S61L	NM_015569.3	NP_056384.2	Q9UQ16	DYN3_HUMAN	dynamin 3	61					endocytosis|filopodium assembly|synapse assembly	dendritic spine|microtubule|perinuclear region of cytoplasm|postsynaptic density	GTP binding|GTPase activity|protein binding			NS(1)|breast(3)|endometrium(1)|kidney(1)|large_intestine(9)|lung(16)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	37						CCTCGAGGGTCGGGCATTGTA	0.433000													9	10					0	0	1	0	0
CPT1C	126129	broad.mit.edu	37	19	50216744	50216744	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr19:50216744G>A	ENST00000392518.4	+	20	2666	c.2294G>A	c.(2293-2295)gGa>gAa	p.G765E	CPT1C_ENST00000354199.5_Missense_Mutation_p.G676E|CPT1C_ENST00000405931.2_Missense_Mutation_p.G754E|CPT1C_ENST00000598293.1_Missense_Mutation_p.G765E|CPT1C_ENST00000323446.5_Missense_Mutation_p.G765E	NM_001199752.1	NP_001186681.1	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C	765					fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		TTCCAGGCGGGACAGCATTTT	0.607000													23	101					0	0	1	0	0
CYFIP2	26999	broad.mit.edu	37	5	156786153	156786153	+	Silent	SNP	C	C	T			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr5:156786153C>T	ENST00000347377.6	+	24	3245	c.2814C>T	c.(2812-2814)agC>agT	p.S938S	CYFIP2_ENST00000318218.6_Silent_p.S963S|CYFIP2_ENST00000521420.1_Silent_p.S912S|CYFIP2_ENST00000541131.1_Silent_p.S863S|CYFIP2_ENST00000442283.2_3'UTR|CYFIP2_ENST00000522463.1_Silent_p.S742S|CYFIP2_ENST00000377576.3_Silent_p.S938S|CYFIP2_ENST00000435847.2_Silent_p.S637S	NM_001037332.2	NP_001032409.2	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	963					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding			breast(1)|endometrium(12)|kidney(2)|lung(23)	38	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TTGTGAAGAGCTTGGTAAGGA	0.453000													13	10					0	0	1	0	0
ABCC11	85320	broad.mit.edu	37	16	48234386	48234386	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr16:48234386C>T	ENST00000394747.1	-	14	2232	c.1883G>A	c.(1882-1884)gGa>gAa	p.G628E	ABCC11_ENST00000356608.2_Missense_Mutation_p.G628E|ABCC11_ENST00000353782.5_Missense_Mutation_p.G628E|ABCC11_ENST00000537808.1_Missense_Mutation_p.G628E|ABCC11_ENST00000394748.1_Missense_Mutation_p.G628E	NM_033151.3	NP_149163.2	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 11	628	ABC transporter 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(3)|prostate(2)|skin(5)|urinary_tract(2)	83		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				GCCCCGCTCTCCAATCTGCAG	0.597000													6	47					0	0	1	0	0
PLD2	5338	broad.mit.edu	37	17	4718857	4718857	+	Silent	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr17:4718857G>A	ENST00000263088.6	+	13	1391	c.1260G>A	c.(1258-1260)ctG>ctA	p.L420L	PLD2_ENST00000572940.1_Silent_p.L420L	NM_001243108.1|NM_002663.4	NP_001230037.1|NP_002654.3	O14939	PLD2_HUMAN	phospholipase D2	420					cell communication|cytoskeleton organization|small GTPase mediated signal transduction		NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(3)|large_intestine(3)|lung(10)|ovary(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)	31					Choline(DB00122)	AGAGGGCGCTGATGCTGCTGC	0.577000											OREG0024105	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	47	165					0	0	1	0	0
SUZ12P1	440423	broad.mit.edu	37	17	29095921	29095921	+	RNA	SNP	C	C	G	rs78029162		TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr17:29095921C>G	ENST00000582557.1	+	0	1220																											TGACCTCAATCAAACAAAACC	0.383000													19	14					0	0	1	0	0
ZNF395	55893	broad.mit.edu	37	8	28210752	28210752	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr8:28210752G>A	ENST00000344423.5	-	5	888	c.757C>T	c.(757-759)Cat>Tat	p.H253Y	ZNF395_ENST00000523202.1_Missense_Mutation_p.H253Y|ZNF395_ENST00000523095.1_Missense_Mutation_p.H253Y	NM_018660.2	NP_061130.1	Q9H8N7	ZN395_HUMAN	zinc finger protein 395	253					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(1)|kidney(5)|large_intestine(6)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.102)|Kidney(114;0.123)|Colorectal(74;0.142)		TCAAAGCCATGATCAGTTTGG	0.587000													23	21					0	0	1	0	0
SEC23IP	11196	broad.mit.edu	37	10	121663630	121663630	+	Silent	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr10:121663630G>A	ENST00000369075.3	+	4	1014	c.942G>A	c.(940-942)acG>acA	p.T314T	SEC23IP_ENST00000543134.1_Silent_p.T103T	NM_007190.3	NP_009121.1	Q9Y6Y8	S23IP_HUMAN	SEC23 interacting protein	314	Interaction with SEC23A.				Golgi organization|intracellular protein transport	endoplasmic reticulum|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment	metal ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(12)|ovary(3)|prostate(1)|stomach(3)|urinary_tract(1)	36		Lung NSC(174;0.109)|all_lung(145;0.142)|all_neural(114;0.234)		all cancers(201;0.00515)		TTCTTGGCACGGATGGAGGGC	0.458000													4	53					0	0	1	0	0
CDH13	1012	broad.mit.edu	37	16	83711918	83711918	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr16:83711918G>A	ENST00000566620.1	+	10	1680	c.1390G>A	c.(1390-1392)Gtc>Atc	p.V464I	CDH13_ENST00000428848.3_Missense_Mutation_p.V425I|CDH13_ENST00000268613.10_Missense_Mutation_p.V511I	NM_001220488.1|NM_001220489.1|NM_001220490.1|NM_001257.4	NP_001207417.1|NP_001207418.1|NP_001207419.1|NP_001248.1	P55290	CAD13_HUMAN	cadherin 13	464	Cadherin 3.				adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)		CACAGCCACCGTCCACATCAC	0.577000													13	69					0	0	1	0	0
DDX4	54514	broad.mit.edu	37	5	55094390	55094390	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr5:55094390C>G	ENST00000505374.1	+	18	1698	c.1606C>G	c.(1606-1608)Cga>Gga	p.R536G	DDX4_ENST00000514278.2_Missense_Mutation_p.R516G|DDX4_ENST00000354991.5_Missense_Mutation_p.R502G|DDX4_ENST00000511853.1_Missense_Mutation_p.R387G|DDX4_ENST00000353507.5_Missense_Mutation_p.R502G	NM_024415.2	NP_077726.1	Q9NQI0	DDX4_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 4	536	Helicase C-terminal.				multicellular organismal development|sperm motility	perinuclear region of cytoplasm|pi-body|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(8)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)	24		Lung NSC(810;6.93e-05)|all_neural(839;0.00409)|Prostate(74;0.0107)|Breast(144;0.0544)|Ovarian(174;0.223)				TGAAATTCTGCGAAACATAGG	0.348000													12	18					0	0	1	0	0
SLC8A2	6543	broad.mit.edu	37	19	47935695	47935695	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr19:47935695C>G	ENST00000236877.6	-	9	2513	c.2118G>C	c.(2116-2118)gaG>gaC	p.E706D	SLC8A2_ENST00000539381.1_Missense_Mutation_p.E169D|SLC8A2_ENST00000601757.1_5'UTR|SLC8A2_ENST00000542837.1_Missense_Mutation_p.E462D	NM_015063.2	NP_055878.1	Q9UPR5	NAC2_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 2	706					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding	p.E706D(1)		breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(2)|prostate(2)|skin(5)|stomach(1)	31		all_cancers(25;3.05e-07)|all_lung(116;4.19e-06)|Lung NSC(112;7.16e-06)|all_epithelial(76;7.65e-06)|all_neural(266;0.0652)|Ovarian(192;0.086)|Breast(70;0.173)		OV - Ovarian serous cystadenocarcinoma(262;0.000501)|all cancers(93;0.00058)|Epithelial(262;0.0181)|GBM - Glioblastoma multiforme(486;0.0457)		CCTCCTCCTCCTCGTCCCCTG	0.602000													5	144					0	0	1	0	0
RAB12	201475	broad.mit.edu	37	18	8624998	8624998	+	Splice_Site	SNP	T	T	C			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr18:8624998T>C	ENST00000329286.6	+	2	570		c.e2+2			NM_001025300.2	NP_001020471.2	Q6IQ22	RAB12_HUMAN	RAB12, member RAS oncogene family						protein transport|small GTPase mediated signal transduction	Golgi membrane	GTP binding			breast(1)|lung(4)|prostate(1)|urinary_tract(1)	7						ACAGATCTGGTAAGTGGGAGA	0.358000													45	96					0	0	1	0	0
HNRNPDL	9987	broad.mit.edu	37	4	83348369	83348369	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr4:83348369C>T	ENST00000295470.5	-	5	1170	c.995G>A	c.(994-996)cGa>cAa	p.R332Q	HNRNPDL_ENST00000349655.4_Missense_Mutation_p.R213Q|HNRNPDL_ENST00000502762.1_Missense_Mutation_p.R332Q|HNRNPDL_ENST00000602300.1_Missense_Mutation_p.R213Q|HNRNPDL_ENST00000514511.1_5'UTR	NM_001207000.1|NM_031372.3	NP_001193929.1|NP_112740.1			heterogeneous nuclear ribonucleoprotein D-like																		CGTACCACCTCGTCCACCAGC	0.438000													66	165					0	0	1	0	0
SLC37A2	219855	broad.mit.edu	37	11	124952197	124952197	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr11:124952197C>A	ENST00000403796.2	+	10	1244	c.943C>A	c.(943-945)Ctc>Atc	p.L315I	SLC37A2_ENST00000298280.5_Missense_Mutation_p.L315I|SLC37A2_ENST00000407458.1_Missense_Mutation_p.L315I|SLC37A2_ENST00000308074.4_Missense_Mutation_p.L315I	NM_001145290.1	NP_001138762.1	Q8TED4	SPX2_HUMAN	solute carrier family 37 (glucose-6-phosphate transporter), member 2	315					carbohydrate transport|transmembrane transport	integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(6)|ovary(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(1)	27	all_hematologic(175;0.215)	Breast(109;0.012)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.152)|all_lung(97;0.159)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0384)		TTACACCTTCCTCTACTGGCT	0.587000													30	48					9.45814e-24	1.05659e-23	1	1	0
ZNF208	7757	broad.mit.edu	37	19	22155282	22155282	+	Missense_Mutation	SNP	T	T	C			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr19:22155282T>C	ENST00000397126.4	-	4	2702	c.2554A>G	c.(2554-2556)Aag>Gag	p.K852E	ZNF208_ENST00000599916.1_Intron|ZNF208_ENST00000601773.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				TGAATTACCTTATGTTTAGTA	0.373000													3	58					0	0	1	0	0
OR6N2	81442	broad.mit.edu	37	1	158746645	158746645	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr1:158746645G>A	ENST00000339258.1	-	1	780	c.781C>T	c.(781-783)Cgg>Tgg	p.R261W		NM_001005278.1	NP_001005278.1	Q8NGY6	OR6N2_HUMAN	olfactory receptor, family 6, subfamily N, member 2	261					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(6)|lung(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_hematologic(112;0.0378)					TTCTTTAGCCGCACATACATG	0.433000													12	38					0	0	1	0	0
AKAP11	11215	broad.mit.edu	37	13	42876628	42876628	+	Nonsense_Mutation	SNP	C	C	G			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr13:42876628C>G	ENST00000025301.2	+	8	3921	c.3746C>G	c.(3745-3747)tCa>tGa	p.S1249*		NM_016248.3	NP_057332.1	Q9UKA4	AKA11_HUMAN	A kinase (PRKA) anchor protein 11	1249					intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(10)|liver(1)|lung(22)|ovary(1)|skin(3)|stomach(2)	56		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		TTAAACCCCTCAGACGAAAAT	0.363000													16	5					0	0	1	0	0
ADAM20	8748	broad.mit.edu	37	14	70991613	70991613	+	Silent	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr14:70991613G>A	ENST00000256389.3	-	2	256	c.12C>T	c.(10-12)ctC>ctT	p.L4L	RP11-486O13.4_ENST00000556646.1_lincRNA	NM_003814.4	NP_003805.3	O43506	ADA20_HUMAN	ADAM metallopeptidase domain 20	0					proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(15)|prostate(1)|skin(2)	27			KIRC - Kidney renal clear cell carcinoma(12;0.133)|Kidney(31;0.188)	all cancers(60;0.00294)|BRCA - Breast invasive adenocarcinoma(234;0.00668)|OV - Ovarian serous cystadenocarcinoma(108;0.0344)		TGTCCTGGTGGAGCTGGACCA	0.522000													67	46					0	0	1	0	0
ZNF91	7644	broad.mit.edu	37	19	23544867	23544867	+	Missense_Mutation	SNP	T	T	C			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr19:23544867T>C	ENST00000300619.7	-	4	1119	c.914A>G	c.(913-915)cAt>cGt	p.H305R	ZNF91_ENST00000599743.1_Intron|ZNF91_ENST00000397082.2_Missense_Mutation_p.H273R	NM_003430.2	NP_003421.2	Q05481	ZNF91_HUMAN	zinc finger protein 91	305						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding						all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				GGTTGAAGAATGGCTAAAAGC	0.413000													6	151					0	0	1	0	0
UTS2R	2837	broad.mit.edu	37	17	80333364	80333364	+	Silent	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr17:80333364G>A	ENST00000313135.2	+	1	1212	c.1164G>A	c.(1162-1164)ccG>ccA	p.P388P		NM_018949.1	NP_061822.1	Q9UKP6	UR2R_HUMAN	urotensin 2 receptor	388						integral to membrane|plasma membrane				breast(1)|endometrium(4)|kidney(1)|lung(2)	8	Breast(20;0.00106)|all_neural(118;0.0804)		OV - Ovarian serous cystadenocarcinoma(97;0.00928)|BRCA - Breast invasive adenocarcinoma(99;0.0833)			CCAGGGCCCCGGCGTGAGCAC	0.761000													5	8					0	0	1	0	0
KLHL26	55295	broad.mit.edu	37	19	18778894	18778894	+	Silent	SNP	G	G	A	rs150852328	byFrequency	TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr19:18778894G>A	ENST00000300976.4	+	3	777	c.687G>A	c.(685-687)gcG>gcA	p.A229A	KLHL26_ENST00000599006.1_Intron	NM_018316.1	NP_060786.1	Q53HC5	KLH26_HUMAN	kelch-like family member 26	229	BACK.									breast(1)|central_nervous_system(1)|kidney(1)|lung(10)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	17						TGTTCCGCGCGGCCGTCCGCT	0.692000													14	22					0	0	1	0	0
PGAM1	5223	broad.mit.edu	37	10	99190742	99190742	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr10:99190742C>G	ENST00000334828.5	+	3	593	c.445C>G	c.(445-447)Cag>Gag	p.Q149E	PGAM1_ENST00000467867.1_3'UTR	NM_002629.2	NP_002620.1	P18669	PGAM1_HUMAN	phosphoglycerate mutase 1 (brain)	149					gluconeogenesis|glycolysis|regulation of glycolysis|regulation of pentose-phosphate shunt|respiratory burst	cytosol	2,3-bisphospho-D-glycerate 2-phosphohydrolase activity|bisphosphoglycerate mutase activity|phosphoglycerate mutase activity|protein kinase binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(1)	6		Colorectal(252;0.162)		Epithelial(162;8.36e-10)|all cancers(201;5.62e-08)		CACAGAAGATCAGCTACCCTC	0.433000													15	28					0	0	1	0	0
ZNF747	65988	broad.mit.edu	37	16	30545884	30545884	+	Silent	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr16:30545884G>A	ENST00000252799.3	-	1	784	c.117C>T	c.(115-117)ttC>ttT	p.F39F	ZNF747_ENST00000569360.1_Silent_p.F39F|ZNF747_ENST00000535210.1_Silent_p.F39F|ZNF747_ENST00000568028.1_Silent_p.F39F|AC002310.13_ENST00000568114.1_Intron|ZNF747_ENST00000395094.3_Silent_p.F39F	NM_023931.2	NP_076420.1	Q9BV97	ZN747_HUMAN	zinc finger protein 747	39	KRAB.				regulation of transcription, DNA-dependent	intracellular	nucleic acid binding			kidney(1)|lung(3)|prostate(1)	5						CCACGTCGGCGAAGCTCACGG	0.731000													5	10					0	0	1	0	0
DMGDH	29958	broad.mit.edu	37	5	78294073	78294073	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr5:78294073C>G	ENST00000255189.3	-	16	2461	c.2433G>C	c.(2431-2433)aaG>aaC	p.K811N		NM_013391.2	NP_037523.2	Q9UI17	M2GD_HUMAN	dimethylglycine dehydrogenase	811					choline metabolic process|glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|dimethylglycine dehydrogenase activity|electron carrier activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(10)|liver(1)|lung(10)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	34		all_lung(232;0.000638)|Lung NSC(167;0.00173)|Ovarian(174;0.0262)|Prostate(461;0.192)		OV - Ovarian serous cystadenocarcinoma(54;6.52e-45)|Epithelial(54;5.96e-40)|all cancers(79;3.56e-35)		AAGCCAGACTCTTCTGGATGC	0.473000													7	11					0	0	1	0	0
DOC2A	8448	broad.mit.edu	37	16	30018508	30018508	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr16:30018508C>T	ENST00000350119.4	-	6	830	c.640G>A	c.(640-642)Gag>Aag	p.E214K	DOC2A_ENST00000564979.1_Missense_Mutation_p.E214K|DOC2A_ENST00000564944.1_Missense_Mutation_p.E214K	NM_001282062.1|NM_001282063.1|NM_001282068.1|NM_003586.2	NP_001268991.1|NP_001268992.1|NP_001268997.1|NP_003577.2	Q14183	DOC2A_HUMAN	double C2-like domains, alpha	214					nervous system development|regulation of calcium ion-dependent exocytosis	cell junction|lysosome|synaptic vesicle membrane|synaptosome	calcium-dependent phospholipid binding|protein binding|transporter activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(2)|ovary(2)	9						ACCTGGCGCTCGAGGCAGATG	0.627000													9	229					0	0	1	0	0
RP1L1	94137	broad.mit.edu	37	8	10466059	10466059	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr8:10466059C>T	ENST00000382483.3	-	4	5772	c.5549G>A	c.(5548-5550)gGt>gAt	p.G1850D		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	1850					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		GGCCTCTACACCTTCTGACTC	0.642000													6	197					0	0	1	0	0
SLFN13	146857	broad.mit.edu	37	17	33769022	33769022	+	Silent	SNP	C	C	T			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr17:33769022C>T	ENST00000285013.6	-	5	1757	c.1482G>A	c.(1480-1482)ttG>ttA	p.L494L	SLFN13_ENST00000526861.1_Silent_p.L494L|SLFN13_ENST00000533791.1_Silent_p.L494L|SLFN13_ENST00000534689.1_Silent_p.L176L|SLFN13_ENST00000542635.1_Silent_p.L494L|SLFN13_ENST00000360502.2_Silent_p.L176L	NM_144682.5	NP_653283.3	Q68D06	SLN13_HUMAN	schlafen family member 13	494						intracellular	ATP binding			NS(1)|breast(1)|endometrium(1)|large_intestine(10)|lung(8)|ovary(3)|pancreas(1)|prostate(5)|stomach(1)	31				UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		GCTTCTGCTTCAAAGTAAAGG	0.582000													5	67					0	0	1	0	0
ENPP2	5168	broad.mit.edu	37	8	120620168	120620168	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr8:120620168C>A	ENST00000427067.2	-	9	995	c.815G>T	c.(814-816)tGg>tTg	p.W272L	ENPP2_ENST00000522826.1_Missense_Mutation_p.W276L|ENPP2_ENST00000259486.6_Missense_Mutation_p.W276L|ENPP2_ENST00000075322.6_Missense_Mutation_p.W276L			Q13822	ENPP2_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 2	276					cellular component movement|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|phosphate metabolic process|phosphatidylcholine catabolic process|regulation of cell migration	extracellular space|integral to plasma membrane	alkylglycerophosphoethanolamine phosphodiesterase activity|calcium ion binding|lysophospholipase activity|nucleic acid binding|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity|transcription factor binding|zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(30)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)	69	Lung NSC(37;5.03e-06)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			TTACACAGACCAAAAGAATGT	0.308000													4	26					0.217242	0.220804	1	1	0
PAN2	9924	broad.mit.edu	37	12	56716212	56716212	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr12:56716212C>T	ENST00000425394.2	-	19	3080	c.2704G>A	c.(2704-2706)Gat>Aat	p.D902N	PAN2_ENST00000548043.1_Missense_Mutation_p.D902N|PAN2_ENST00000440411.3_Missense_Mutation_p.D898N|PAN2_ENST00000257931.5_Missense_Mutation_p.D901N	NM_001127460.2	NP_001120932	Q504Q3	PAN2_HUMAN	PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)	902					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			NS(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|liver(1)|lung(18)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	41						CTAACCTTATCAATAGGTTCA	0.408000													12	42					0	0	1	0	0
ABCC11	85320	broad.mit.edu	37	16	48234387	48234387	+	Nonsense_Mutation	SNP	C	C	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr16:48234387C>A	ENST00000394747.1	-	14	2231	c.1882G>T	c.(1882-1884)Gga>Tga	p.G628*	ABCC11_ENST00000356608.2_Nonsense_Mutation_p.G628*|ABCC11_ENST00000353782.5_Nonsense_Mutation_p.G628*|ABCC11_ENST00000537808.1_Nonsense_Mutation_p.G628*|ABCC11_ENST00000394748.1_Nonsense_Mutation_p.G628*	NM_033151.3	NP_149163.2	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 11	628	ABC transporter 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(3)|prostate(2)|skin(5)|urinary_tract(2)	83		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				CCCCGCTCTCCAATCTGCAGA	0.592000													6	46					8.12818e-05	8.54148e-05	1	1	0
ICAM5	7087	broad.mit.edu	37	19	10402342	10402342	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr19:10402342G>A	ENST00000221980.4	+	3	593	c.530G>A	c.(529-531)cGg>cAg	p.R177Q	ICAM5_ENST00000586004.1_3'UTR	NM_003259.3	NP_003250.3	Q9UMF0	ICAM5_HUMAN	intercellular adhesion molecule 5, telencephalin	177	Ig-like C2-type 2.				cell-cell adhesion	integral to plasma membrane				breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)	21			OV - Ovarian serous cystadenocarcinoma(20;2.64e-09)|Epithelial(33;4.31e-06)|all cancers(31;9.75e-06)			CCCCGAGCGCGGGGCGCGGTG	0.736000													7	23					0	0	1	0	0
NHLRC1	378884	broad.mit.edu	37	6	18121856	18121856	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr6:18121856C>G	ENST00000340650.3	-	1	995	c.982G>C	c.(982-984)Gat>Cat	p.D328H		NM_198586.2	NP_940988.2	Q6VVB1	NHLC1_HUMAN	NHL repeat containing 1	328					proteasomal ubiquitin-dependent protein catabolic process|protein polyubiquitination	endoplasmic reticulum|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|kidney(1)|large_intestine(3)|lung(3)|skin(1)|urinary_tract(2)	11	Ovarian(93;0.016)|Breast(50;0.0245)	all_hematologic(90;0.165)	all cancers(50;0.0451)|Epithelial(50;0.0493)			CCCTGGTGATCAAAGGTCACA	0.483000													61	76					0	0	1	0	0
RPAIN	84268	broad.mit.edu	37	17	5331461	5331461	+	Missense_Mutation	SNP	G	G	T			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr17:5331461G>T	ENST00000381209.3	+	6	1130	c.560G>T	c.(559-561)tGt>tTt	p.C187F	RPAIN_ENST00000405578.4_Missense_Mutation_p.C187F|CTC-524C5.2_ENST00000575890.1_RNA|RPAIN_ENST00000327154.6_Intron|RPAIN_ENST00000574003.1_3'UTR|RPAIN_ENST00000536255.2_Intron|RPAIN_ENST00000381208.5_Intron	NM_001033002.3	NP_001028174.2	Q86UA6	RIP_HUMAN	RPA interacting protein	187					DNA recombination|DNA repair|DNA-dependent DNA replication|protein import into nucleus|response to UV	cytoplasm|nucleolus|PML body	metal ion binding|protein complex binding			breast(1)|kidney(1)|large_intestine(2)|lung(1)|prostate(1)	6						AGTGCACATTGTCCCCACACA	0.463000													48	53					6.3237e-29	7.19393e-29	1	1	0
LSG1	55341	broad.mit.edu	37	3	194373664	194373664	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr3:194373664C>T	ENST00000265245.5	-	8	1281	c.967G>A	c.(967-969)Gaa>Aaa	p.E323K		NM_018385.2	NP_060855.2	Q9H089	LSG1_HUMAN	large 60S subunit nuclear export GTPase 1	323					nuclear export|protein transport	Cajal body|endoplasmic reticulum	GTP binding|hydrolase activity			breast(2)|endometrium(3)|large_intestine(2)|lung(9)	16	all_cancers(143;1.68e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;4.34e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;7.55e-06)		CCGTCTTCTTCTGAGCACGTC	0.527000													4	70					0	0	1	0	0
ITGA3	3675	broad.mit.edu	37	17	48155574	48155574	+	Silent	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr17:48155574G>A	ENST00000320031.8	+	18	2553	c.2223G>A	c.(2221-2223)tcG>tcA	p.S741S	ITGA3_ENST00000007722.7_Silent_p.S741S	NM_002204.2|NM_005501.2	NP_002195.1|NP_005492.1	P26006	ITA3_HUMAN	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)	741					blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|leukocyte migration	cell surface|integrin complex	protein binding|receptor activity			endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(2)	31						TCCCAAGGTCGAGTCACCAGG	0.572000													5	87					0	0	1	0	0
TOM1L1	10040	broad.mit.edu	37	17	52993152	52993152	+	Silent	SNP	C	C	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr17:52993152C>A	ENST00000575882.1	+	7	1002	c.649C>A	c.(649-651)Cga>Aga	p.R217R	TOM1L1_ENST00000445275.2_Silent_p.R217R|TOM1L1_ENST00000348161.4_Silent_p.R140R|TOM1L1_ENST00000575333.1_Silent_p.R217R|TOM1L1_ENST00000572158.1_Silent_p.R210R|TOM1L1_ENST00000536554.1_Silent_p.R140R|TOM1L1_ENST00000540336.1_Silent_p.R105R|TOM1L1_ENST00000572405.1_Silent_p.R182R|TOM1L1_ENST00000570371.1_Silent_p.R217R	NM_005486.2	NP_005477.2	O75674	TM1L1_HUMAN	target of myb1 (chicken)-like 1	217	GAT.				intracellular protein transport|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	cytosol|endosome membrane|Golgi stack|lysosome	SH3 domain binding|ubiquitin binding			cervix(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|skin(1)	15						AATGAATGTGCGAGTGATGTC	0.433000													3	92					0.150653	0.155675	1	1	0
MRC1	4360	broad.mit.edu	37	10	17891674	17891674	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr10:17891674G>C	ENST00000331429.2	+	7	1258	c.1155G>C	c.(1153-1155)agG>agC	p.R385S	MRC1L1_ENST00000457317.1_Missense_Mutation_p.R385S																breast(1)|endometrium(1)|large_intestine(1)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14						AAATCCAGAGGGATGCTCTGA	0.473000													29	42					0	0	1	0	0
NHLRC1	378884	broad.mit.edu	37	6	18122786	18122786	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr6:18122786C>T	ENST00000340650.3	-	1	65	c.52G>A	c.(52-54)Gag>Aag	p.E18K		NM_198586.2	NP_940988.2	Q6VVB1	NHLC1_HUMAN	NHL repeat containing 1	18					proteasomal ubiquitin-dependent protein catabolic process|protein polyubiquitination	endoplasmic reticulum|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding	p.E18*(1)		breast(1)|kidney(1)|large_intestine(3)|lung(3)|skin(1)|urinary_tract(2)	11	Ovarian(93;0.016)|Breast(50;0.0245)	all_hematologic(90;0.165)	all cancers(50;0.0451)|Epithelial(50;0.0493)			ATCTCCGCCTCGCGCATGAGC	0.711000													18	33					0	0	1	0	0
ZNF329	79673	broad.mit.edu	37	19	58639722	58639722	+	Silent	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr19:58639722G>A	ENST00000598312.1	-	4	1382	c.1149C>T	c.(1147-1149)aaC>aaT	p.N383N	ZNF329_ENST00000358067.4_Silent_p.N383N	NM_024620.3	NP_078896.3	Q86UD4	ZN329_HUMAN	zinc finger protein 329	383					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|large_intestine(10)|lung(5)|skin(3)|urinary_tract(1)	20		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.029)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.017)|Lung(386;0.216)		TGAGGTGAGAGTTTCTGTTGA	0.498000													35	102					0	0	1	0	0
ZNF768	79724	broad.mit.edu	37	16	30536523	30536523	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr16:30536523C>T	ENST00000380412.5	-	2	1113	c.938G>A	c.(937-939)gGc>gAc	p.G313D	ZNF768_ENST00000562803.1_Missense_Mutation_p.G282D	NM_024671.3	NP_078947.3	Q9H5H4	ZN768_HUMAN	zinc finger protein 768	313					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|prostate(1)	15						GGGCCGCTCGCCAGTGTGGGT	0.607000													14	49					0	0	1	0	0
ACPL2	92370	broad.mit.edu	37	3	141011518	141011518	+	Missense_Mutation	SNP	A	A	G			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr3:141011518A>G	ENST00000508812.1	+	5	2794	c.887A>G	c.(886-888)aAt>aGt	p.N296S	RP11-438D8.2_ENST00000507698.1_RNA|ACPL2_ENST00000286353.4_Missense_Mutation_p.N305S|ACPL2_ENST00000393007.1_Missense_Mutation_p.N289S|ACPL2_ENST00000502783.1_Missense_Mutation_p.N267S|ACPL2_ENST00000504264.1_Missense_Mutation_p.N288S|ACPL2_ENST00000393010.2_Missense_Mutation_p.N305S			Q8TE99	ACPL2_HUMAN	acid phosphatase-like 2	305						extracellular region	acid phosphatase activity			endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|prostate(2)|skin(2)	23						TTCTGCCACAATGTCAGCTTT	0.517000													12	79					0	0	1	0	0
PREX1	57580	broad.mit.edu	37	20	47266680	47266680	+	Missense_Mutation	SNP	G	G	A	rs41283554		TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr20:47266680G>A	ENST00000396220.1	-	24	2904	c.2882C>T	c.(2881-2883)cCg>cTg	p.P961L	PREX1_ENST00000371941.3_Missense_Mutation_p.P961L			Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	961					actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(27)|lung(53)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	110			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			GCCACACAGCGGGTGGGGCTC	0.592000													33	132					0	0	1	0	0
TSSK1B	83942	broad.mit.edu	37	5	112769745	112769745	+	Silent	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr5:112769745G>A	ENST00000390666.3	-	1	983	c.792C>T	c.(790-792)gaC>gaT	p.D264D	MCC_ENST00000408903.3_Intron|CTD-2201G3.1_ENST00000416046.2_RNA|CTD-2201G3.1_ENST00000383058.4_RNA	NM_032028.3	NP_114417.1	Q9BXA7	TSSK1_HUMAN	testis-specific serine kinase 1B	264	Protein kinase.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(8)|ovary(2)|skin(2)|stomach(1)	13		all_cancers(142;0.0138)|all_epithelial(76;0.000445)|Colorectal(10;0.00814)|Prostate(80;0.0115)|Ovarian(225;0.156)		Epithelial(69;4.15e-08)|OV - Ovarian serous cystadenocarcinoma(64;4.49e-08)|all cancers(49;3.2e-06)|COAD - Colon adenocarcinoma(37;0.0371)|Colorectal(14;0.0449)		TGAGGATCTCGTCGATGTGGA	0.617000													4	32					0	0	1	0	0
EDEM1	9695	broad.mit.edu	37	3	5249807	5249807	+	Silent	SNP	C	C	T			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr3:5249807C>T	ENST00000256497.4	+	8	1501	c.1368C>T	c.(1366-1368)atC>atT	p.I456I	EDEM1_ENST00000445686.1_Silent_p.I261I	NM_014674.2	NP_055489.1	Q92611	EDEM1_HUMAN	ER degradation enhancer, mannosidase alpha-like 1	456					ER-associated protein catabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	integral to endoplasmic reticulum membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding	p.I456M(1)		NS(1)|breast(1)|endometrium(1)|large_intestine(5)|liver(2)|lung(4)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	22				Epithelial(13;0.0588)|OV - Ovarian serous cystadenocarcinoma(96;0.0682)		AAGATGCCATCTGCCTTCATG	0.512000													47	93					0	0	1	0	0
C8A	731	broad.mit.edu	37	1	57373628	57373628	+	Splice_Site	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr1:57373628G>A	ENST00000361249.3	+	9	1318		c.e9-1			NM_000562.2	NP_000553.1	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide						complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	43						CTTGATGGCAGAAAGGGCCAG	0.488000													14	38					0	0	1	0	0
ZNF347	84671	broad.mit.edu	37	19	53644380	53644380	+	Silent	SNP	T	T	C			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr19:53644380T>C	ENST00000452676.2	-	5	2130	c.1704A>G	c.(1702-1704)aaA>aaG	p.K568K	ZNF347_ENST00000334197.7_Silent_p.K567K|ZNF347_ENST00000601469.2_Silent_p.K568K|ZNF347_ENST00000601804.1_Intron	NM_001172674.1	NP_001166145.1	Q96SE7	ZN347_HUMAN	zinc finger protein 347	567					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(6)|lung(8)|prostate(3)|skin(1)	23				GBM - Glioblastoma multiforme(134;0.0179)		ATTTGTAAGGTTTTTCTCCAG	0.413000													6	250					0	0	1	0	0
CPVL	54504	broad.mit.edu	37	7	29070210	29070210	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr7:29070210C>G	ENST00000409850.1	-	16	1949	c.1303G>C	c.(1303-1305)Gcg>Ccg	p.A435P	CPVL_ENST00000396276.3_Missense_Mutation_p.A435P|CPVL_ENST00000265394.5_Missense_Mutation_p.A435P			Q9H3G5	CPVL_HUMAN	carboxypeptidase, vitellogenic-like	435			A -> V (in dbSNP:rs7313).		proteolysis		protein binding|serine-type carboxypeptidase activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|ovary(2)|prostate(1)|skin(1)	28						AAGTCACCCGCTTGCCGGATG	0.478000													167	185					0	0	1	0	0
PCDHA2	56146	broad.mit.edu	37	5	140175132	140175132	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr5:140175132G>A	ENST00000526136.1	+	1	583	c.583G>A	c.(583-585)Gtg>Atg	p.V195M	PCDHA2_ENST00000378132.1_Missense_Mutation_p.V195M|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000520672.2_Missense_Mutation_p.V195M	NM_018905.2	NP_061728.1														NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(16)|lung(26)|ovary(4)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTTGTCTCTCGTGCTGGGGAA	0.463000													24	34					0	0	1	0	0
NUP98	4928	broad.mit.edu	37	11	3794864	3794864	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr11:3794864C>G	ENST00000324932.7	-	6	1021	c.601G>C	c.(601-603)Gag>Cag	p.E201Q	NUP98_ENST00000359171.4_Missense_Mutation_p.E201Q|NUP98_ENST00000397004.4_Missense_Mutation_p.E201Q|NUP98_ENST00000355260.3_Missense_Mutation_p.E201Q|NUP98_ENST00000397007.4_Missense_Mutation_p.E201Q	NM_016320.4|NM_139132.3	NP_057404.2|NP_624358.2	P52948	NUP98_HUMAN	nucleoporin 98kDa	201	Gly/Thr-rich.				carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(13)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		TTACTGACCTCTAGTGACTTG	0.343000			T	"""HOXA9, NSD1, WHSC1L1, DDX10, TOP1, HOXD13, PMX1, HOXA13, HOXD11, HOXA11, RAP1GDS1, HOXC11"""	AML								11	8					0	0	1	0	0
OR5A2	219981	broad.mit.edu	37	11	59189895	59189895	+	Missense_Mutation	SNP	A	A	C			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr11:59189895A>C	ENST00000302040.4	-	1	554	c.532T>G	c.(532-534)Ttt>Gtt	p.F178V		NM_001001954.1	NP_001001954.1	Q8NGI9	OR5A2_HUMAN	olfactory receptor, family 5, subfamily A, member 2	178					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|liver(1)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	21						TCACAGAAAAAGTGGTTGATC	0.483000													3	65					0	0	1	0	0
SGK1	6446	broad.mit.edu	37	6	134498841	134498841	+	Silent	SNP	G	G	T			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr6:134498841G>T	ENST00000528577.1	-	1	202	c.120C>A	c.(118-120)acC>acA	p.T40T	SGK1_ENST00000367858.5_Intron	NM_001143677.1	NP_001137149.1	O00141	SGK1_HUMAN	serum/glucocorticoid regulated kinase 1	302	Necessary for localization to the cytoplasm.				apoptosis|response to stress|sodium ion transport	endoplasmic reticulum|nucleus|plasma membrane	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(21)|kidney(3)|large_intestine(3)|lung(10)|ovary(1)|skin(4)|stomach(1)	46	Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.00317)|GBM - Glioblastoma multiforme(68;0.00847)		TCATTCTTCGGGTTGCCCAAG	0.468000													10	23					0.457914	0.461636	1	1	0
OR6X1	390260	broad.mit.edu	37	11	123624493	123624493	+	Missense_Mutation	SNP	A	A	G			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr11:123624493A>G	ENST00000327930.2	-	1	760	c.734T>C	c.(733-735)gTt>gCt	p.V245A		NM_001005188.1	NP_001005188.1	Q8NH79	OR6X1_HUMAN	olfactory receptor, family 6, subfamily X, member 1	245					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)|endometrium(3)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(2)	23		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		CAGGGAGACAACTGTCAGGTG	0.453000													13	22					0	0	1	0	0
IRAK2	3656	broad.mit.edu	37	3	10264330	10264330	+	Missense_Mutation	SNP	T	T	G			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr3:10264330T>G	ENST00000256458.4	+	9	1114	c.1024T>G	c.(1024-1026)Ttg>Gtg	p.L342V		NM_001570.3	NP_001561.3	O43187	IRAK2_HUMAN	interleukin-1 receptor-associated kinase 2	342	Protein kinase.				activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|interleukin-1-mediated signaling pathway|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of NF-kappaB transcription factor activity|positive regulation of NF-kappaB transcription factor activity|regulation of cytokine-mediated signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|endosome membrane|plasma membrane	ATP binding|NF-kappaB-inducing kinase activity|protein heterodimerization activity|protein homodimerization activity			breast(4)|large_intestine(8)|lung(11)|prostate(1)|stomach(1)	25						CTCTAATGTCTTGCTGGACCA	0.453000													64	259					0	0	1	0	0
SWI5	375757	broad.mit.edu	37	9	131038427	131038427	+	Translation_Start_Site	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr9:131038427G>A	ENST00000320188.5	+	1	3	c.3G>A	c.(1-3)atG>atA	p.M1I	SWI5_ENST00000495313.1_Intron	NM_001040011.1	NP_001035100.1	Q1ZZU3	SWI5_HUMAN	SWI5 recombination repair homolog (yeast)						double-strand break repair via homologous recombination	Swi5-Sfr1 complex	protein binding										GCGTGGCTATGCAGCGGCGTG	0.627000													45	57					0	0	1	0	0
HOMEZ	57594	broad.mit.edu	37	14	23746018	23746018	+	Missense_Mutation	SNP	G	G	T			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr14:23746018G>T	ENST00000357460.5	-	2	583	c.419C>A	c.(418-420)tCt>tAt	p.S140Y	HOMEZ_ENST00000431326.2_Missense_Mutation_p.S142Y|HOMEZ_ENST00000561013.1_Missense_Mutation_p.S142Y	NM_020834.2	NP_065885.2	Q8IX15	HOMEZ_HUMAN	homeobox and leucine zipper encoding	140						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(5)|lung(7)	12	all_cancers(95;5.54e-06)			GBM - Glioblastoma multiforme(265;0.00643)		ATGAGTAAAAGAGAGAAGGGA	0.537000													34	89					1.58521e-26	1.78696e-26	1	1	0
ENPP2	5168	broad.mit.edu	37	8	120598469	120598469	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr8:120598469C>G	ENST00000427067.2	-	15	1492	c.1312G>C	c.(1312-1314)Gag>Cag	p.E438Q	ENPP2_ENST00000522826.1_Missense_Mutation_p.E442Q|ENPP2_ENST00000259486.6_Missense_Mutation_p.E494Q|ENPP2_ENST00000522167.1_Missense_Mutation_p.E81Q|ENPP2_ENST00000075322.6_Missense_Mutation_p.E442Q			Q13822	ENPP2_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 2	442					cellular component movement|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|phosphate metabolic process|phosphatidylcholine catabolic process|regulation of cell migration	extracellular space|integral to plasma membrane	alkylglycerophosphoethanolamine phosphodiesterase activity|calcium ion binding|lysophospholipase activity|nucleic acid binding|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity|transcription factor binding|zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(30)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)	69	Lung NSC(37;5.03e-06)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			TGGATATCCTCAATTCTTCTG	0.413000													25	60					0	0	1	0	0
WNK3	65267	broad.mit.edu	37	X	54321158	54321158	+	Missense_Mutation	SNP	C	C	G	rs149832313	byFrequency	TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chrX:54321158C>G	ENST00000354646.2	-	8	1959	c.1521G>C	c.(1519-1521)agG>agC	p.R507S	WNK3_ENST00000375169.3_Missense_Mutation_p.R507S|WNK3_ENST00000375159.2_Missense_Mutation_p.R507S	NM_020922.4	NP_065973.2	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3	507					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			autonomic_ganglia(1)|biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(24)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80						ACTGAGAATCCCTGCGTTCTT	0.478000													27	2					0	0	1	0	0
SMOC1	64093	broad.mit.edu	37	14	70418941	70418941	+	Silent	SNP	C	C	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr14:70418941C>A	ENST00000381280.4	+	2	439	c.186C>A	c.(184-186)tcC>tcA	p.S62S	SMOC1_ENST00000361956.3_Silent_p.S62S|SMOC1_ENST00000555917.1_3'UTR	NM_001034852.2|NM_022137.5	NP_001030024.1|NP_071420.1	Q9H4F8	SMOC1_HUMAN	SPARC related modular calcium binding 1	62	Kazal-like.				cell differentiation|eye development|limb development|regulation of osteoblast differentiation|signal transduction	basement membrane	calcium ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	21				all cancers(60;0.00417)|BRCA - Breast invasive adenocarcinoma(234;0.0119)|OV - Ovarian serous cystadenocarcinoma(108;0.028)		ATGGCAGGTCCTACGAGTCCA	0.562000													32	75					9.62906e-15	1.06607e-14	1	1	0
HERC2	8924	broad.mit.edu	37	15	28458889	28458889	+	Splice_Site	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr15:28458889G>A	ENST00000261609.7	-	42	6893	c.6785C>T	c.(6784-6786)cCa>cTa	p.P2262L		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	2262					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		TTCACCTACTGGTTTCAGCTG	0.478000													14	22					0	0	1	0	0
BPTF	2186	broad.mit.edu	37	17	65941562	65941562	+	Silent	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr17:65941562G>A	ENST00000321892.4	+	23	7177	c.7116G>A	c.(7114-7116)caG>caA	p.Q2372Q	BPTF_ENST00000306378.6_Silent_p.Q2246Q|BPTF_ENST00000424123.3_Silent_p.Q2233Q|BPTF_ENST00000335221.5_Silent_p.Q2372Q			Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	2372					brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(23)|ovary(3)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	78	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			TGTCACCCCAGATGCAGGTAC	0.478000													27	58					0	0	1	0	0
HCN1	348980	broad.mit.edu	37	5	45262592	45262592	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr5:45262592C>T	ENST00000303230.4	-	8	2161	c.2104G>A	c.(2104-2106)Gcg>Acg	p.A702T		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	702						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						CTGCAGACCGCGGTGGTGTAG	0.642000													15	4					0	0	1	0	0
SEC13	6396	broad.mit.edu	37	3	10342968	10342968	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr3:10342968C>G	ENST00000383801.2	-	10	1155	c.1084G>C	c.(1084-1086)Gag>Cag	p.E362Q	SEC13_ENST00000350697.3_Missense_Mutation_p.E316Q|SEC13_ENST00000492602.1_Intron|SEC13_ENST00000397117.1_Intron|SEC13_ENST00000337354.4_Missense_Mutation_p.E319Q|SEC13_ENST00000397109.3_Missense_Mutation_p.E302Q	NM_001136026.2	NP_001129498.1	P55735	SEC13_HUMAN	SEC13 homolog (S. cerevisiae)	316					COPII vesicle coating|intracellular protein transport|mitotic prometaphase|mRNA transport|post-translational protein modification|protein N-linked glycosylation via asparagine|transmembrane transport	cytosol|endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Nup107-160 complex	protein binding			NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	17						TGCTGGCCCTCTGTCACTGAT	0.607000													24	236					0	0	1	0	0
SEZ6L2	26470	broad.mit.edu	37	16	29883848	29883848	+	Splice_Site	SNP	C	C	G			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr16:29883848C>G	ENST00000308713.5	-	15	3016		c.e15-1		SEZ6L2_ENST00000350527.3_Splice_Site|SEZ6L2_ENST00000537485.1_Splice_Site|SEZ6L2_ENST00000346932.5_Splice_Site	NM_001114099.2|NM_201575.3	NP_001107571.1|NP_963869.2	Q6UXD5	SE6L2_HUMAN	seizure related 6 homolog (mouse)-like 2							endoplasmic reticulum membrane|integral to membrane|plasma membrane				breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(16)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						GTCTGGGTCACTACAGGAGGA	0.657000													15	64					0	0	1	0	0
CHD6	84181	broad.mit.edu	37	20	40049547	40049547	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr20:40049547C>G	ENST00000373233.3	-	31	5905	c.5728G>C	c.(5728-5730)Gat>Cat	p.D1910H		NM_032221.3	NP_115597.3	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	1910					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(24)|lung(53)|ovary(8)|prostate(5)|skin(8)|stomach(1)|urinary_tract(9)	129		Myeloproliferative disorder(115;0.00425)				TTGGTTTCATCTTGGAAGCCT	0.522000													23	42					0	0	1	0	0
TIGD2	166815	broad.mit.edu	37	4	90034311	90034311	+	Silent	SNP	C	C	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr4:90034311C>A	ENST00000317005.2	+	1	344	c.186C>A	c.(184-186)acC>acA	p.T62T		NM_145715.2	NP_663761.1	Q4W5G0	TIGD2_HUMAN	tigger transposable element derived 2	62					regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	14		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;3.86e-05)		CAGATCCTACCAGTGGAGTAT	0.368000													3	56					1	1	1	1	0
TGM1	7051	broad.mit.edu	37	14	24731538	24731538	+	Silent	SNP	G	G	A	rs150913268	by1000genomes	TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr14:24731538G>A	ENST00000206765.6	-	2	144	c.21C>T	c.(19-21)tcC>tcT	p.S7S	TGM1_ENST00000544573.1_5'UTR	NM_000359.2	NP_000350.1	P22735	TGM1_HUMAN	transglutaminase 1	7	Membrane anchorage region.				cell envelope organization|keratinization|peptide cross-linking	cornified envelope|intrinsic to membrane	acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)	24				GBM - Glioblastoma multiforme(265;0.0186)	L-Glutamine(DB00130)	GGCCCACATCGGAACGTGGCC	0.632000													15	47					0	0	1	0	0
ZNF768	79724	broad.mit.edu	37	16	30537018	30537018	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr16:30537018C>A	ENST00000380412.5	-	2	618	c.443G>T	c.(442-444)aGa>aTa	p.R148I	ZNF768_ENST00000562803.1_Missense_Mutation_p.R117I	NM_024671.3	NP_078947.3	Q9H5H4	ZN768_HUMAN	zinc finger protein 768	148					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|prostate(1)	15						GGATTCATATCTAGAGCTCTC	0.527000													22	77					8.10497e-08	8.58989e-08	1	1	0
TCOF1	6949	broad.mit.edu	37	5	149755460	149755460	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr5:149755460G>C	ENST00000451292.1	+	12	1989	c.1881G>C	c.(1879-1881)atG>atC	p.M627I	TCOF1_ENST00000513346.1_Missense_Mutation_p.M627I|TCOF1_ENST00000323668.7_Missense_Mutation_p.M550I|TCOF1_ENST00000394269.3_Missense_Mutation_p.M627I|TCOF1_ENST00000445265.2_Missense_Mutation_p.M550I|TCOF1_ENST00000439160.2_Missense_Mutation_p.M627I|TCOF1_ENST00000504761.2_Missense_Mutation_p.M627I|TCOF1_ENST00000377797.3_Missense_Mutation_p.M627I			Q13428	TCOF_HUMAN	Treacher Collins-Franceschetti syndrome 1	627					skeletal system development	nucleolus	protein binding|transporter activity			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(8)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	35		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CAGCAGCCATGACTGCAGCTC	0.627000													7	18					0	0	1	0	0
IRS2	8660	broad.mit.edu	37	13	110436504	110436504	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr13:110436504C>T	ENST00000375856.3	-	1	2411	c.1897G>A	c.(1897-1899)Gga>Aga	p.G633R		NM_003749.2	NP_003740.2	Q9Y4H2	IRS2_HUMAN	insulin receptor substrate 2	633					fibroblast growth factor receptor signaling pathway|glucose metabolic process|insulin receptor signaling pathway|lipid homeostasis|negative regulation of B cell apoptosis|negative regulation of kinase activity|negative regulation of plasma membrane long-chain fatty acid transport|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of B cell proliferation|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|response to glucose stimulus	cytosol|plasma membrane	insulin receptor binding|signal transducer activity			kidney(2)|large_intestine(2)|lung(8)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	19	all_cancers(4;7.57e-15)|all_epithelial(4;5.91e-09)|all_lung(23;7.64e-07)|Lung NSC(43;0.000183)|Colorectal(4;0.00159)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0155)	Breast(118;0.159)	all cancers(43;0.00815)|BRCA - Breast invasive adenocarcinoma(86;0.11)|Epithelial(84;0.127)|GBM - Glioblastoma multiforme(44;0.147)			TCGATGTCTCCGTAGTCCTCT	0.711000													5	5					0	0	1	0	0
CD209	30835	broad.mit.edu	37	19	7810767	7810767	+	Missense_Mutation	SNP	G	G	A	rs146082308		TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr19:7810767G>A	ENST00000315599.7	-	4	407	c.385C>T	c.(385-387)Cgg>Tgg	p.R129W	CD209_ENST00000394161.5_Intron|CD209_ENST00000301357.8_Missense_Mutation_p.R85W|CD209_ENST00000354397.6_Missense_Mutation_p.R129W|CD209_ENST00000593660.1_Missense_Mutation_p.R105W|CD209_ENST00000602261.1_Missense_Mutation_p.R129W|CD209_ENST00000601256.1_Missense_Mutation_p.R105W|CD209_ENST00000593821.1_Missense_Mutation_p.R85W|CD209_ENST00000394173.4_Intron|CD209_ENST00000315591.8_Missense_Mutation_p.R105W|CD209_ENST00000601951.1_Missense_Mutation_p.R105W|CD209_ENST00000204801.8_Missense_Mutation_p.R85W	NM_001144895.1|NM_001144897.1|NM_021155.3	NP_001138367.1|NP_001138369.1|NP_066978.1	Q9NNX6	CD209_HUMAN	CD209 molecule	129	7 X approximate tandem repeats.				cell-cell recognition|endocytosis|heterophilic cell-cell adhesion|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to membrane|plasma membrane	mannose binding|metal ion binding|peptide antigen binding|receptor activity|virion binding	p.R129W(4)		endometrium(7)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						GCCTTCAGCCGGGTCAGCTCC	0.567000													5	292					0	0	1	0	0
FLII	2314	broad.mit.edu	37	17	18155374	18155374	+	Silent	SNP	C	C	T	rs145214604		TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr17:18155374C>T	ENST00000327031.4	-	11	1410	c.1185G>A	c.(1183-1185)tcG>tcA	p.S395S	FLII_ENST00000579294.1_Silent_p.S384S|FLII_ENST00000578558.1_Silent_p.S395S|FLII_ENST00000379450.4_Silent_p.S310S|FLII_ENST00000545457.2_Silent_p.S341S	NM_002018.3	NP_002009.1	Q13045	FLII_HUMAN	flightless I homolog (Drosophila)	395	Interaction with LRRFIP1 and LRRFIP2.				multicellular organismal development|muscle contraction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleus	actin binding			central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32	all_neural(463;0.228)					GGTTCTGCAGCGAGAAGTCGA	0.652000													43	43					0	0	1	0	0
ZNF768	79724	broad.mit.edu	37	16	30537349	30537349	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr16:30537349C>T	ENST00000380412.5	-	2	287	c.112G>A	c.(112-114)Gag>Aag	p.E38K	ZNF747_ENST00000569360.1_3'UTR|ZNF747_ENST00000535210.1_3'UTR|ZNF768_ENST00000562803.1_Missense_Mutation_p.E7K	NM_024671.3	NP_078947.3	Q9H5H4	ZN768_HUMAN	zinc finger protein 768	38	Poly-Glu.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|prostate(1)	15						gaaatttcctctTCCTCATTC	0.507000													29	139					0	0	1	0	0
WDR34	89891	broad.mit.edu	37	9	131397988	131397988	+	Silent	SNP	C	C	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr9:131397988C>A	ENST00000372715.2	-	5	822	c.762G>T	c.(760-762)ctG>ctT	p.L254L	WDR34_ENST00000483181.1_5'UTR	NM_052844.3	NP_443076.2	Q96EX3	WDR34_HUMAN	WD repeat domain 34	254						cytoplasm				central_nervous_system(2)|lung(5)|skin(1)|urinary_tract(1)	9						TGCGCCACAGCAGCGGGTCCT	0.692000													3	38					0.00909568	0.00947785	1	1	0
MTMR6	9107	broad.mit.edu	37	13	25840079	25840079	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr13:25840079C>T	ENST00000381801.5	-	5	1230	c.469G>A	c.(469-471)Gaa>Aaa	p.E157K	MTMR6_ENST00000540661.1_Missense_Mutation_p.E157K	NM_004685.3	NP_004676.3	Q9Y217	MTMR6_HUMAN	myotubularin related protein 6	157	Myotubularin phosphatase.					cytoplasm|nuclear envelope	calcium-activated potassium channel activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			breast(2)|endometrium(3)|kidney(3)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)|skin(5)|stomach(3)	36		Lung SC(185;0.0225)|Breast(139;0.0351)		all cancers(112;0.00927)|Epithelial(112;0.0474)|OV - Ovarian serous cystadenocarcinoma(117;0.164)		GGGTAAGTTTCACAAATCTGT	0.353000													11	17					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578454	7578454	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr17:7578454G>A	ENST00000420246.2	-	5	608	c.476C>T	c.(475-477)gCc>gTc	p.A159V	TP53_ENST00000455263.2_Missense_Mutation_p.A159V|TP53_ENST00000359597.4_Missense_Mutation_p.A159V|TP53_ENST00000269305.4_Missense_Mutation_p.A159V|TP53_ENST00000445888.2_Missense_Mutation_p.A159V|TP53_ENST00000413465.2_Missense_Mutation_p.A159V	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	159	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		A -> D (in sporadic cancers; somatic mutation).|A -> F (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|A -> G (in sporadic cancers; somatic mutation).|A -> P (in sporadic cancers; somatic mutation).|A -> S (in sporadic cancers; somatic mutation).|A -> T (in sporadic cancers; somatic mutation).|A -> V (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.A159V(33)|p.0?(8)|p.A159D(7)|p.R158fs(6)|p.R65fs(2)|p.R158_A159delRA(2)|p.R156_I162delRVRAMAI(2)|p.V157fs*9(2)|p.R26fs(2)|p.V157_C176del20(1)|p.R156_A161delRVRAMA(1)|p.P151_V173del23(1)|p.R156fs*18(1)|p.R156_A161del(1)|p.V157_M160delVRAM(1)|p.R158fs*11(1)|p.A66V(1)|p.S149fs*72(1)|p.A159fs*21(1)|p.T155_A161delTRVRAMA(1)|p.A27V(1)|p.R156fs*20(1)|p.V157_I162delVRAMAI(1)|p.A159_Q167delAMAIYKQSQ(1)|p.V157fs*21(1)|p.R158fs*8(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GATGGCCATGGCGCGGACGCG	0.627000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			48	8					0	0	1	0	0
ZNF513	130557	broad.mit.edu	37	2	27600891	27600892	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr2:27600891_27600892delTG	ENST00000323703.6	-	4	1344_1345	c.1146_1147delCA	c.(1144-1149)cacagtfs	p.HS382fs	ZNF513_ENST00000491924.1_5'UTR|ZNF513_ENST00000407879.1_Frame_Shift_Del_p.HS320fs	NM_144631.5	NP_653232.3	Q8N8E2	ZN513_HUMAN	zinc finger protein 513	382					regulation of transcription, DNA-dependent|response to stimulus|retina development in camera-type eye|transcription, DNA-dependent|visual perception	nucleus	transcription regulatory region DNA binding|zinc ion binding	p.S383C(1)		endometrium(5)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)	17	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTCTCACCACTGTGTGTCTTCA	0.609													57	160	---	---	---	---					
PMS2P3	5387	broad.mit.edu	37	7	75145720	75145721	+	RNA	DEL	AT	AT	-			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr7:75145720_75145721delAT	ENST00000418756.1	-	0	618					NR_028059.1															lung(1)	1						TCCTTTGGGGatatatatatat	0.302													2	4	---	---	---	---					
FAM157B	100132403	broad.mit.edu	37	9	141107536	141107537	+	RNA	INS	-	-	GCA			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr9:141107536_141107537insGCA	ENST00000446912.2	+	0	19_20							P0CG42	F157B_HUMAN																			CGgcagcggcggcagcagcagc	0.545													6	6	---	---	---	---					
PRB2	653247	broad.mit.edu	37	12	11546856	11546858	+	In_Frame_Del	DEL	AGA	AGA	-			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr12:11546856_11546858delAGA	ENST00000389362.4	-	3	189_191	c.154_156delTCT	c.(154-156)tctdel	p.S52del	PRB1_ENST00000546254.1_Intron	NM_006248.3	NP_006239.3			proline-rich protein BstNI subfamily 2									p.?(2)|p.A39_G59delAPPQGGNKPQGPPSPPGKPQG(1)		NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(14)|pancreas(1)|prostate(5)|skin(4)|stomach(2)|urinary_tract(1)	37		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			TTCCTGGAGGAGATGGGGGACCT	0.557													8	147	---	---	---	---					
SLC5A11	115584	broad.mit.edu	37	16	24921737	24921739	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr16:24921737_24921739delCAG	ENST00000347898.3	+	15	2383_2385	c.1761_1763delCAG	c.(1759-1764)gccagc>gcc	p.S592del	SLC5A11_ENST00000545376.1_In_Frame_Del_p.S522del|SLC5A11_ENST00000449109.2_In_Frame_Del_p.S436del|SLC5A11_ENST00000568579.1_In_Frame_Del_p.S522del|SLC5A11_ENST00000567758.1_In_Frame_Del_p.S557del|SLC5A11_ENST00000565769.1_In_Frame_Del_p.S528del|SLC5A11_ENST00000424767.2_In_Frame_Del_p.S557del|SLC5A11_ENST00000539472.1_In_Frame_Del_p.S528del|SLC5A11_ENST00000569071.1_In_Frame_Del_p.S436del	NM_052944.3	NP_443176.2	Q8WWX8	SC5AB_HUMAN	solute carrier family 5 (sodium/inositol cotransporter), member 11	592					apoptosis|carbohydrate transport|sodium ion transport	integral to membrane|plasma membrane	polyol transmembrane transporter activity|symporter activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(30)|ovary(2)|prostate(2)|urinary_tract(1)	49				GBM - Glioblastoma multiforme(48;0.0365)		TGCCAGAGGCCAGCAGCAGCAGC	0.542													18	826	---	---	---	---					
TAOK2	9344	broad.mit.edu	37	16	29998498	29998500	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr16:29998498_29998500delCTG	ENST00000308893.4	+	16	3948_3950	c.2905_2907delCTG	c.(2905-2907)ctgdel	p.L974del	TAOK2_ENST00000416441.2_In_Frame_Del_p.L801del|TAOK2_ENST00000543033.1_In_Frame_Del_p.L861del|TAOK2_ENST00000279394.3_Intron	NM_001252043.1|NM_016151.3	NP_001238972.1|NP_057235.2	Q9UL54	TAOK2_HUMAN	TAO kinase 2	974	Leu-rich.				actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|large_intestine(5)|lung(8)|ovary(1)|prostate(3)|skin(1)	22						CCTGCCCCTCCTGCTGCTGCTGC	0.709													7	435	---	---	---	---					
LOC101927978	101927978	broad.mit.edu	37	16	72763868	72763868	+	RNA	DEL	C	C	-			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr16:72763868delC	ENST00000563328.2	+	0	164																											CGGTCCAAAACAAAAAAAAAA	0.433													2	4	---	---	---	---					
AP003900.6	0	broad.mit.edu	37	21	11181291	11181292	+	RNA	INS	-	-	CC			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr21:11181291_11181292insCC	ENST00000603265.1	+	0	231																											AATGCGTATTTCACTGTCAGAG	0.485													9	123	---	---	---	---