Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CHEK1	1111	broad.mit.edu	37	11	125513987	125513987	+	Splice_Site	SNP	G	G	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr11:125513987G>A	ENST00000534070.1	+	10	1180	c.925G>A	c.(925-927)Gaa>Aaa	p.E309K	CHEK1_ENST00000428830.2_Splice_Site_p.E309K|CHEK1_ENST00000427383.2_Splice_Site_p.E325K|CHEK1_ENST00000524737.1_Splice_Site_p.E309K|CHEK1_ENST00000544373.1_Splice_Site_p.E309K|CHEK1_ENST00000278916.3_Splice_Site_p.E309K|CHEK1_ENST00000438015.1_Splice_Site_p.E309K|CHEK1_ENST00000532449.1_3'UTR	NM_001274.5	NP_001265.2	O14757	CHK1_HUMAN	checkpoint kinase 1	309					cellular response to mechanical stimulus|DNA repair|DNA replication|gamete generation|negative regulation of cell proliferation|reciprocal meiotic recombination|regulation of cyclin-dependent protein kinase activity|replicative senescence	condensed nuclear chromosome|microtubule organizing center|nucleoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(3)|endometrium(3)|large_intestine(2)|lung(16)|skin(1)|upper_aerodigestive_tract(1)	26	all_hematologic(175;0.228)	Breast(109;0.0021)|Lung NSC(97;0.0126)|all_lung(97;0.0132)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0748)		ATGCCTCAGTGAAGAAAATGT	0.378000								Other conserved DNA damage response genes					38	26					0	0	1	0	0
NOTCH1	4851	broad.mit.edu	37	9	139399897	139399897	+	Missense_Mutation	SNP	T	T	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr9:139399897T>A	ENST00000277541.6	-	25	4526	c.4451A>T	c.(4450-4452)aAt>aTt	p.N1484I		NM_017617.3	NP_060087.3	P46531	NOTC1_HUMAN	notch 1	1484					aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(16)|central_nervous_system(17)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1183)|kidney(4)|large_intestine(1)|lung(57)|oesophagus(2)|ovary(3)|pancreas(1)|prostate(3)|skin(21)|upper_aerodigestive_tract(39)|urinary_tract(3)	1359	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		CCAGGGGTCATTGAAGTTGAG	0.622000			"""T, Mis, O"""	TRB@	T-ALL					HNSCC(8;0.001)			9	36					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100686998	100686998	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr7:100686998C>T	ENST00000306151.4	+	3	12365	c.12301C>T	c.(12301-12303)Cgg>Tgg	p.R4101W		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	4101						extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					ACCCAGCACACGGACCACTTC	0.562000													28	102					0	0	1	0	0
FSTL3	10272	broad.mit.edu	37	19	681360	681360	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr19:681360G>A	ENST00000166139.4	+	4	565	c.533G>A	c.(532-534)cGg>cAg	p.R178Q	FSTL3_ENST00000592947.1_3'UTR	NM_005860.2	NP_005851.1	O95633	FSTL3_HUMAN	follistatin-like 3 (secreted glycoprotein)	178	Follistatin-like 2.				hemopoietic progenitor cell differentiation|negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of osteoclast differentiation|ossification|positive regulation of cell-cell adhesion|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	extracellular space|nucleus	activin binding|fibronectin binding						all_epithelial(18;2.19e-21)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTGTGCCCGCGGCCACAGTCG	0.701000			T	CCND1	B-CLL								6	11					0	0	1	0	0
PTPN9	5780	broad.mit.edu	37	15	75762295	75762295	+	Missense_Mutation	SNP	G	G	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr15:75762295G>T	ENST00000306726.2	-	12	1917	c.1405C>A	c.(1405-1407)Cca>Aca	p.P469T		NM_002833.2	NP_002824.1	P43378	PTN9_HUMAN	protein tyrosine phosphatase, non-receptor type 9	469	Tyrosine-protein phosphatase.					cytoplasmic part	non-membrane spanning protein tyrosine phosphatase activity|protein binding			central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						CCATAGTCTGGCCAGCTCAAG	0.507000													15	48					5.01169e-05	5.16543e-05	1	1	0
NTS	4922	broad.mit.edu	37	12	86272345	86272345	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr12:86272345G>A	ENST00000256010.6	+	3	465	c.358G>A	c.(358-360)Gag>Aag	p.E120K	NTS_ENST00000551529.1_Intron	NM_006183.4	NP_006174.1	P30990	NEUT_HUMAN	neurotensin	120					regulation of blood vessel size|signal transduction	extracellular region|soluble fraction|transport vesicle	neuropeptide hormone activity			large_intestine(2)|lung(6)	8						TCAACACTGGGAGGTATAGCA	0.333000													6	41					0	0	1	0	0
KBTBD3	143879	broad.mit.edu	37	11	105929784	105929784	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr11:105929784C>T	ENST00000526793.1	-	2	200	c.41G>A	c.(40-42)cGa>cAa	p.R14Q	KBTBD3_ENST00000531482.2_Missense_Mutation_p.R14Q|KBTBD3_ENST00000531837.1_Missense_Mutation_p.R14Q|KBTBD3_ENST00000534815.1_Intron	NM_152433.3	NP_689646.2	Q8NAB2	KBTB3_HUMAN	kelch repeat and BTB (POZ) domain containing 3	10										NS(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(9)|lung(6)|ovary(1)|prostate(1)	25		Melanoma(852;0.000878)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0321)		BRCA - Breast invasive adenocarcinoma(274;5.43e-05)|Epithelial(105;0.00418)|all cancers(92;0.0299)		ACATGTGCTTCGTTGATTGAA	0.328000													4	35					0	0	1	0	0
PRR4	11272	broad.mit.edu	37	12	11000981	11000981	+	Silent	SNP	G	G	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr12:11000981G>A	ENST00000228811.4	-	2	127	c.90C>T	c.(88-90)ttC>ttT	p.F30F	PRR4_ENST00000536668.1_5'UTR|PRR4_ENST00000540107.1_Silent_p.F30F|PRR4_ENST00000544994.1_Silent_p.F30F	NM_007244.2	NP_009175.2	Q16378	PROL4_HUMAN	proline rich 4 (lacrimal)	30					visual perception	extracellular space				endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)	9						CTGGTATGGTGAAAGTAAAGT	0.358000													15	15					0	0	1	0	0
PRSS38	339501	broad.mit.edu	37	1	228005156	228005156	+	Silent	SNP	G	G	A	rs139000968	by1000genomes	TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr1:228005156G>A	ENST00000366757.3	+	3	582	c.558G>A	c.(556-558)acG>acA	p.T186T		NM_183062.2	NP_898885.1	A1L453	PRS38_HUMAN	protease, serine, 38	186	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23						GCTGGGCTACGGGATGGGGAC	0.527000													12	74					0	0	1	0	0
MAP3K1	4214	broad.mit.edu	37	5	56177590	56177590	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr5:56177590C>T	ENST00000399503.3	+	14	2563	c.2563C>T	c.(2563-2565)Cgt>Tgt	p.R855C		NM_005921.1	NP_005912.1	Q13233	M3K1_HUMAN	mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase	855					cellular response to mechanical stimulus|innate immune response|MyD88-dependent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|zinc ion binding			NS(1)|breast(19)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(11)|ovary(1)|skin(3)|urinary_tract(1)	57		Lung NSC(810;4.65e-05)|Prostate(74;0.0132)|Breast(144;0.0321)|Ovarian(174;0.223)		OV - Ovarian serous cystadenocarcinoma(10;6.08e-40)		GATGCGTCGCCGTTTGATGGC	0.478000													8	80					0	0	1	0	0
MORC1	27136	broad.mit.edu	37	3	108682322	108682322	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr3:108682322G>C	ENST00000232603.5	-	27	2820	c.2738C>G	c.(2737-2739)tCt>tGt	p.S913C	MORC1_ENST00000483760.1_Missense_Mutation_p.S892C	NM_014429.3	NP_055244.3	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	913					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			breast(7)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(47)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	105						CTTATCCTCAGAGATTTTTCT	0.343000													38	55					0	0	1	0	0
TPO	7173	broad.mit.edu	37	2	1497623	1497623	+	Silent	SNP	C	C	T	rs148782927	by1000genomes	TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr2:1497623C>T	ENST00000345913.4	+	11	1909	c.1818C>T	c.(1816-1818)ccC>ccT	p.P606P	TPO_ENST00000497517.2_3'UTR|TPO_ENST00000382198.1_Silent_p.P433P|TPO_ENST00000349624.3_Silent_p.P433P|TPO_ENST00000346956.3_Silent_p.P606P|TPO_ENST00000329066.4_Silent_p.P606P|TPO_ENST00000382201.3_Silent_p.P549P|TPO_ENST00000337415.3_Silent_p.P606P	NM_000547.5	NP_000538.3	P07202	PERT_HUMAN	thyroid peroxidase	606					cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	TGGAGACCCCCGCTGACCTGA	0.577000													11	17					0	0	1	0	0
CAMK2A	815	broad.mit.edu	37	5	149618312	149618312	+	Splice_Site	SNP	C	C	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr5:149618312C>A	ENST00000348628.6	-	14	1650		c.e14-1		CAMK2A_ENST00000351010.6_Splice_Site|CAMK2A_ENST00000398376.3_Splice_Site	NM_015981.3|NM_171825.2	NP_057065.2|NP_741960.1	Q9UQM7	KCC2A_HUMAN	calcium/calmodulin-dependent protein kinase II alpha						interferon-gamma-mediated signaling pathway|positive regulation of NF-kappaB transcription factor activity|synaptic transmission	cell junction|cytosol|endocytic vesicle membrane|nucleoplasm|presynaptic membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(6)|skin(1)|stomach(1)	15		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CTGAGGATTCCTGCCAAAGAG	0.602000													3	16					1	1	1	1	0
DLC1	10395	broad.mit.edu	37	8	12957624	12957624	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr8:12957624C>G	ENST00000276297.4	-	9	2631	c.2222G>C	c.(2221-2223)aGc>aCc	p.S741T	DLC1_ENST00000512044.2_Missense_Mutation_p.S338T|DLC1_ENST00000520226.1_Missense_Mutation_p.S230T|DLC1_ENST00000358919.2_Missense_Mutation_p.S304T	NM_182643.2	NP_872584.2	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1	741	Poly-Ser.				actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(39)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	110						GCTGCTGCTGCTGGTCTGCGT	0.627000													3	90					0	0	1	0	0
LGI2	55203	broad.mit.edu	37	4	25005321	25005321	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr4:25005321C>A	ENST00000382114.4	-	8	1575	c.1390G>T	c.(1390-1392)Gcc>Tcc	p.A464S		NM_018176.3	NP_060646.2	Q8N0V4	LGI2_HUMAN	leucine-rich repeat LGI family, member 2	464						extracellular region				breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(15)|prostate(1)|skin(3)|stomach(2)	33		Breast(46;0.173)				AGGGTCATGGCCCCCCGGGAT	0.512000													27	146					3.00307e-07	3.19313e-07	1	1	0
CYP2A6	1548	broad.mit.edu	37	19	41354273	41354273	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr19:41354273C>T	ENST00000301141.5	-	4	525	c.505G>A	c.(505-507)Gat>Aat	p.D169N	CTC-490E21.12_ENST00000601627.1_Intron	NM_000762.5	NP_000753	P11509	CP2A6_HUMAN	cytochrome P450, family 2, subfamily A, polypeptide 6	169					coumarin catabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|enzyme binding|heme binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(9)|ovary(3)|prostate(5)|skin(2)|upper_aerodigestive_tract(2)	37			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)		Chlorzoxazone(DB00356)|Diethylstilbestrol(DB00255)|Estradiol(DB00783)|Ethinyl Estradiol(DB00977)|Formoterol(DB00983)|Halothane(DB01159)|Letrozole(DB01006)|Methoxsalen(DB00553)|Metyrapone(DB01011)|Nicotine(DB00184)|Pilocarpine(DB01085)|Tolbutamide(DB01124)|Tranylcypromine(DB00752)	AAGGTGGGATCGATATTGGCG	0.542000													17	95					0	0	1	0	0
FZD3	7976	broad.mit.edu	37	8	28385479	28385479	+	Missense_Mutation	SNP	G	G	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr8:28385479G>T	ENST00000240093.3	+	5	1680	c.1202G>T	c.(1201-1203)cGa>cTa	p.R401L	FZD3_ENST00000537916.1_Missense_Mutation_p.R401L	NM_017412.3	NP_059108.1	Q9NPG1	FZD3_HUMAN	frizzled family receptor 3	401					canonical Wnt receptor signaling pathway|cell proliferation in midbrain|commissural neuron axon guidance|establishment of planar polarity|facial nucleus development|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|inner ear morphogenesis|neural tube closure|vasculature development	apical part of cell|axon|cytoplasm|dendrite|integral to membrane|neuron projection membrane|neuronal cell body|presynaptic active zone	G-protein coupled receptor activity|PDZ domain binding|Wnt-protein binding			central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(14)|lung(15)|ovary(1)|prostate(1)|skin(1)	41		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.109)|Kidney(114;0.13)|Colorectal(74;0.23)		AACAGAGTTCGAATTGAGATT	0.403000													82	83					1.17611e-34	1.32609e-34	1	1	0
DPY19L2P2	349152	broad.mit.edu	37	7	102825947	102825947	+	RNA	SNP	A	A	G			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr7:102825947A>G	ENST00000312132.4	-	0	3750																											ACAGCTTGACACTTGCCATTG	0.373000													4	74					0	0	1	0	0
TP63	8626	broad.mit.edu	37	3	189455639	189455639	+	Missense_Mutation	SNP	T	T	C			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr3:189455639T>C	ENST00000264731.3	+	2	262	c.173T>C	c.(172-174)aTc>aCc	p.I58T	TP63_ENST00000440651.2_Missense_Mutation_p.I58T|TP63_ENST00000392460.3_Missense_Mutation_p.I58T|TP63_ENST00000320472.5_Missense_Mutation_p.I58T|TP63_ENST00000382063.4_Missense_Mutation_p.I58T|TP63_ENST00000418709.2_Missense_Mutation_p.I58T	NM_001114978.1|NM_003722.4	NP_001108450.1|NP_003713.3	Q9H3D4	P63_HUMAN	tumor protein p63	58	Transcription activation.				anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(5)|large_intestine(12)|lung(15)|ovary(2)|skin(9)|upper_aerodigestive_tract(6)	61	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		TTCCAGCATATCTGGGATTTT	0.403000										HNSCC(45;0.13)			14	51					0	0	1	0	0
SPECC1	92521	broad.mit.edu	37	17	20108086	20108086	+	Missense_Mutation	SNP	G	G	A	rs144644210		TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr17:20108086G>A	ENST00000395530.2	+	2	689	c.481G>A	c.(481-483)Gat>Aat	p.D161N	SPECC1_ENST00000395522.2_Missense_Mutation_p.D161N|SPECC1_ENST00000472876.1_Intron|SPECC1_ENST00000536879.1_Intron|SPECC1_ENST00000395525.3_Missense_Mutation_p.D161N|AC004702.2_ENST00000580225.1_lincRNA|SPECC1_ENST00000395527.4_Missense_Mutation_p.D242N|SPECC1_ENST00000395529.3_Missense_Mutation_p.D242N|SPECC1_ENST00000261503.5_Missense_Mutation_p.D242N	NM_001033555.2	NP_001028727.1	Q5M775	CYTSB_HUMAN	sperm antigen with calponin homology and coiled-coil domains 1	242						nucleus				breast(1)|large_intestine(3)|ovary(4)	8				KIRC - Kidney renal clear cell carcinoma(2;0.166)|Kidney(2;0.196)		AGAGCTTTCCGATCTAGAGGA	0.498000													28	110					0	0	1	0	0
TOMM34	10953	broad.mit.edu	37	20	43572202	43572202	+	Silent	SNP	G	G	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr20:43572202G>A	ENST00000372813.3	-	6	869	c.717C>T	c.(715-717)gtC>gtT	p.V239V	PABPC1L_ENST00000490798.1_Intron|PABPC1L_ENST00000372819.1_Intron	NM_006809.4	NP_006800.2	Q15785	TOM34_HUMAN	translocase of outer mitochondrial membrane 34	239					protein targeting to mitochondrion	integral to membrane|mitochondrial outer membrane	heat shock protein binding|signal sequence binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)	11		Myeloproliferative disorder(115;0.0122)				ACTGCTTCAGGACCAAATAGC	0.502000													17	84					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110498987	110498987	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr8:110498987G>A	ENST00000378402.5	+	59	9921	c.9817G>A	c.(9817-9819)Gag>Aag	p.E3273K		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	3273					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			CGGTTGGTCTGAGGACTCTTT	0.423000										HNSCC(38;0.096)			59	336					0	0	1	0	0
NAV3	89795	broad.mit.edu	37	12	78360077	78360077	+	Silent	SNP	T	T	C			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr12:78360077T>C	ENST00000397909.2	+	4	656	c.483T>C	c.(481-483)gcT>gcC	p.A161A	NAV3_ENST00000536525.2_Silent_p.A161A|NAV3_ENST00000266692.7_Silent_p.A161A|NAV3_ENST00000228327.6_Silent_p.A161A			Q8IVL0	NAV3_HUMAN	neuron navigator 3	161	CH.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						GTCTATCTGCTGAAGGTAAGA	0.338000										HNSCC(70;0.22)			18	22					0	0	1	0	0
NBR1	4077	broad.mit.edu	37	17	41343528	41343528	+	Missense_Mutation	SNP	A	A	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr17:41343528A>T	ENST00000422280.1	+	10	1462	c.1003A>T	c.(1003-1005)Atc>Ttc	p.I335F	NBR1_ENST00000590996.1_Missense_Mutation_p.I335F|NBR1_ENST00000341165.6_Missense_Mutation_p.I335F|NBR1_ENST00000589872.1_Missense_Mutation_p.I335F|NBR1_ENST00000389312.4_Missense_Mutation_p.I335F|NBR1_ENST00000542611.1_Missense_Mutation_p.I314F	NM_031858.2	NP_114064.1	Q14596	NBR1_HUMAN	neighbor of BRCA1 gene 1	335					macroautophagy|protein oligomerization	autophagic vacuole|cytoplasmic vesicle|cytosol|late endosome|lysosome|sarcomere	ubiquitin binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|kidney(4)|large_intestine(1)|lung(7)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	24		Breast(137;0.00086)		BRCA - Breast invasive adenocarcinoma(366;0.0934)		GTGGAATTCAATCCATGGACT	0.478000													3	11					0	0	1	0	0
RNF5	6048	broad.mit.edu	37	6	32146400	32146400	+	Missense_Mutation	SNP	G	G	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr6:32146400G>T	ENST00000427134.2	+	1	127	c.112G>T	c.(112-114)Gtg>Ttg	p.V38L	RNF5_ENST00000487940.1_3'UTR|RNF5_ENST00000375094.3_Missense_Mutation_p.V38L			Q99942	RNF5_HUMAN	ring finger protein 5, E3 ubiquitin protein ligase	38					ER-associated misfolded protein catabolic process|protein K48-linked ubiquitination|protein K63-linked ubiquitination	endoplasmic reticulum membrane|integral to membrane|mitochondrial membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(1)|lung(7)|urinary_tract(2)	10						TCGGGAAGCTGTGGTCAGTGT	0.612000													29	97					1.57019e-19	1.71294e-19	1	1	0
PCDHGB1	56104	broad.mit.edu	37	5	140730581	140730581	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr5:140730581G>A	ENST00000523390.1	+	1	754	c.754G>A	c.(754-756)Gta>Ata	p.V252I	PCDHGA3_ENST00000253812.6_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_018922.2|NM_032095.1	NP_061745.1|NP_115266.1														central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)	16			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCAAGAAAACGTACCGTGGGG	0.522000													17	66					0	0	1	0	0
OR2T12	127064	broad.mit.edu	37	1	248458735	248458735	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr1:248458735C>A	ENST00000317996.1	-	1	145	c.146G>T	c.(145-147)tGg>tTg	p.W49L		NM_001004692.1	NP_001004692.1	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T, member 12	49					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(3)|large_intestine(3)|lung(25)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	43	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			CCGGTGGTCCCAGTGAATCAG	0.537000													22	36					1.67886e-27	1.86787e-27	1	1	0
GCNT2	2651	broad.mit.edu	37	6	10586259	10586259	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr6:10586259C>G	ENST00000265012.4	+	1	281	c.37C>G	c.(37-39)Ctg>Gtg	p.L13V	GCNT2_ENST00000379597.3_Intron|GCNT2_ENST00000495262.1_Intron|GCNT2_ENST00000397423.2_Intron|GCNT2_ENST00000410107.1_Intron|GCNT2_ENST00000316170.3_Intron	NM_145655.3	NP_663630.2	Q8N0V5	GNT2A_HUMAN	glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)	14						Golgi membrane|integral to membrane	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			endometrium(2)|kidney(1)|large_intestine(5)|lung(2)|ovary(2)	12	Ovarian(93;0.107)|Breast(50;0.148)	all_hematologic(90;0.107)		KIRC - Kidney renal clear cell carcinoma(1;0.099)|Kidney(1;0.119)		TGCTTTCACTCTGCTCAGCGT	0.403000													42	54					0	0	1	0	0
IFI44	10561	broad.mit.edu	37	1	79115948	79115948	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr1:79115948G>A	ENST00000370747.4	+	2	153	c.68G>A	c.(67-69)cGg>cAg	p.R23Q	IFI44_ENST00000495254.1_Intron|IFI44_ENST00000545124.1_Intron	NM_006417.4	NP_006408.3	Q8TCB0	IFI44_HUMAN	interferon-induced protein 44	23					response to virus	cytoplasm				central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(4)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	21						GGAGGGAAGCGGCTTAGCCTT	0.403000													19	55					0	0	1	0	0
XIST	7503	broad.mit.edu	37	X	73066652	73066652	+	RNA	SNP	A	A	G			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chrX:73066652A>G	ENST00000429829.1	-	0	5936					NR_001564.2																						AATTGTCATTAGGCACATTAA	0.423000													18	28					0	0	1	0	0
ATF7IP	55729	broad.mit.edu	37	12	14577646	14577646	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr12:14577646C>T	ENST00000544627.1	+	2	1141	c.821C>T	c.(820-822)tCt>tTt	p.S274F	ATF7IP_ENST00000541654.1_3'UTR|ATF7IP_ENST00000261168.4_Missense_Mutation_p.S266F|ATF7IP_ENST00000536444.1_Missense_Mutation_p.S266F|ATF7IP_ENST00000543189.1_Missense_Mutation_p.S266F|ATF7IP_ENST00000540793.1_Missense_Mutation_p.S266F			Q6VMQ6	MCAF1_HUMAN	activating transcription factor 7 interacting protein	266					DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			cervix(1)|endometrium(7)|kidney(5)|large_intestine(10)|liver(2)|lung(22)|ovary(1)|prostate(4)|skin(1)|urinary_tract(1)	54						GAACTGGCCTCTGATGATCTG	0.483000													29	86					0	0	1	0	0
ABR	29	broad.mit.edu	37	17	1028677	1028677	+	Translation_Start_Site	SNP	G	G	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr17:1028677G>A	ENST00000544583.2	-	0	548				ABR_ENST00000302538.5_Silent_p.Y29Y|ABR_ENST00000574437.1_De_novo_Start_OutOfFrame	NM_001159746.2	NP_001153218.1	Q12979	ABR_HUMAN	active BCR-related						apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39				UCEC - Uterine corpus endometrioid carcinoma (25;0.0228)		CCTCTCCGTCGTACTCGTCCG	0.627000													44	142					0	0	1	0	0
IREB2	3658	broad.mit.edu	37	15	78790398	78790398	+	Silent	SNP	C	C	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr15:78790398C>T	ENST00000258886.8	+	22	2954	c.2805C>T	c.(2803-2805)agC>agT	p.S935S		NM_004136.2	NP_004127	P48200	IREB2_HUMAN	iron-responsive element binding protein 2	935							4 iron, 4 sulfur cluster binding|metal ion binding|protein binding			central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(14)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	41				UCEC - Uterine corpus endometrioid carcinoma (272;0.232)		AAGTATTCAGCGTGATTGCTT	0.363000													5	53					0	0	1	0	0
PLEKHG1	57480	broad.mit.edu	37	6	151055093	151055093	+	Silent	SNP	A	A	G			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr6:151055093A>G	ENST00000367328.1	+	3	588	c.276A>G	c.(274-276)agA>agG	p.R92R	PLEKHG1_ENST00000358517.2_Silent_p.R92R	NM_001029884.1	NP_001025055.1	Q9ULL1	PKHG1_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 1	92					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(19)|ovary(5)|prostate(4)|stomach(1)|urinary_tract(3)	53			BRCA - Breast invasive adenocarcinoma(37;0.0923)	OV - Ovarian serous cystadenocarcinoma(155;6.69e-13)		CGCAGTGGAGAGTGGACTCAA	0.602000													5	31					0	0	1	0	0
SLC9A3	6550	broad.mit.edu	37	5	484634	484634	+	Splice_Site	SNP	C	C	T	rs144524702		TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr5:484634C>T	ENST00000264938.3	-	5	942		c.e5+1		SLC9A3_ENST00000514375.1_Splice_Site	NM_004174.2	NP_004165.2	P48764	SL9A3_HUMAN	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3							cell surface|integral to membrane	sodium:hydrogen antiporter activity			NS(2)|biliary_tract(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|liver(2)|lung(16)|prostate(3)|skin(2)|urinary_tract(1)	37			Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			GAGGGACTCACGCGAGGATGG	0.642000													17	31					0	0	1	0	0
MAATS1	89876	broad.mit.edu	37	3	119445049	119445049	+	Silent	SNP	G	G	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr3:119445049G>A	ENST00000273390.5	+	7	791	c.714G>A	c.(712-714)gtG>gtA	p.V238V		NM_033364.3	NP_203528			MYCBP-associated, testis expressed 1																		AAGCTGAGGTGGAGATGATAG	0.532000													14	28					0	0	1	0	0
AARD	441376	broad.mit.edu	37	8	117950663	117950663	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr8:117950663C>T	ENST00000378279.3	+	1	226	c.181C>T	c.(181-183)Cga>Tga	p.R61*		NM_001025357.2	NP_001020528.1	Q4LEZ3	AARD_HUMAN	alanine and arginine rich domain containing protein	61	Ala/Arg-rich.																GGACCTCAGACGACGGCTGAC	0.746000													4	35					0	0	1	0	0
ADAMTS7	11173	broad.mit.edu	37	15	79060507	79060507	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr15:79060507C>A	ENST00000388820.4	-	17	2823	c.2613G>T	c.(2611-2613)caG>caT	p.Q871H	ADAMTS7_ENST00000566303.1_5'UTR	NM_014272.3	NP_055087.2	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 7	871	TSP type-1 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(23)|ovary(1)|prostate(8)|skin(9)	54						TGCACTTCCTCTGTTGGTCAT	0.697000													7	18					5.18039e-06	5.37226e-06	1	1	0
CSMD3	114788	broad.mit.edu	37	8	113694839	113694839	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr8:113694839G>A	ENST00000297405.5	-	16	2753	c.2509C>T	c.(2509-2511)Cct>Tct	p.P837S	CSMD3_ENST00000455883.2_Missense_Mutation_p.P733S|CSMD3_ENST00000352409.3_Missense_Mutation_p.P837S|CSMD3_ENST00000343508.3_Missense_Mutation_p.P797S	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	837	Sushi 4.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						GGTATTCCAGGATCAGGGCAT	0.358000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			15	164					0	0	1	0	0
MROH5	389690	broad.mit.edu	37	8	142481169	142481169	+	RNA	SNP	C	C	G			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr8:142481169C>G	ENST00000430863.1	-	0	2072					NM_207414.2	NP_997297.2			maestro heat-like repeat family member 5																		TGTGGCACATCAAGAGCTGGT	0.592000													77	338					0	0	1	0	0
ITPR1	3708	broad.mit.edu	37	3	4687373	4687373	+	Silent	SNP	C	C	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr3:4687373C>A	ENST00000302640.8	+	10	1166	c.816C>A	c.(814-816)gcC>gcA	p.A272A	ITPR1_ENST00000423119.2_Silent_p.A272A|ITPR1_ENST00000357086.4_Silent_p.A272A|ITPR1_ENST00000456211.2_Silent_p.A272A|ITPR1_ENST00000544951.1_Silent_p.A272A|ITPR1_ENST00000443694.2_Silent_p.A272A|ITPR1_ENST00000354582.6_Silent_p.A272A	NM_001168272.1	NP_001161744.1	Q14643	ITPR1_HUMAN	inositol 1,4,5-trisphosphate receptor, type 1	272	MIR 3.				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(10)|endometrium(15)|kidney(6)|large_intestine(27)|liver(1)|lung(27)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(2)	106				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		GGCAGTCGGCCACATCTGCCA	0.552000													3	43					1	1	1	1	0
ASCC3	10973	broad.mit.edu	37	6	101307003	101307003	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr6:101307003C>T	ENST00000369143.2	-	4	608	c.317G>A	c.(316-318)aGa>aAa	p.R106K	ASCC3_ENST00000522650.1_Intron|ASCC3_ENST00000369162.2_Intron	NM_022091.3	NP_071374.1	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit 3	0					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(20)|liver(1)|lung(36)|ovary(6)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	92		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		tcctctgaatctgtcagaagc	0.353000													9	37					0	0	1	0	0
TBC1D1	23216	broad.mit.edu	37	4	38016441	38016441	+	Silent	SNP	G	G	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr4:38016441G>A	ENST00000261439.4	+	3	1084	c.729G>A	c.(727-729)tcG>tcA	p.S243S	TBC1D1_ENST00000508802.1_Silent_p.S243S	NM_001253914.1|NM_001253915.1|NM_015173.3	NP_001240843.1|NP_001240844.1|NP_055988.2	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1	243						nucleus	Rab GTPase activator activity			NS(1)|breast(3)|kidney(1)|large_intestine(5)|lung(19)|ovary(2)|prostate(2)|skin(2)|urinary_tract(1)	36						GCCTGCGCTCGCTGGCCTTTA	0.672000													7	7					0	0	1	0	0
MTMR7	9108	broad.mit.edu	37	8	17157445	17157445	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr8:17157445C>T	ENST00000180173.5	-	14	1943	c.1909G>A	c.(1909-1911)Ggt>Agt	p.G637S	VPS37A_ENST00000521162.1_3'UTR|MTMR7_ENST00000398099.3_Missense_Mutation_p.G228S	NM_004686.4	NP_004677.3	Q9Y216	MTMR7_HUMAN	myotubularin related protein 7	637							protein tyrosine phosphatase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(5)|liver(1)|lung(8)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	32				Colorectal(111;0.112)		TGCTCACCACCACTTGGAGAC	0.498000													70	66					0	0	1	0	0
RUSC2	9853	broad.mit.edu	37	9	35547012	35547012	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr9:35547012G>A	ENST00000455600.1	+	2	1063	c.494G>A	c.(493-495)cGg>cAg	p.R165Q	RUSC2_ENST00000468041.1_3'UTR	NM_001135999.1	NP_001129471	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	165						cytosol				NS(1)|breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|lung(4)|ovary(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			ACACGCAGTCGGGCTGGAGTG	0.622000													22	69					0	0	1	0	0
SFXN4	119559	broad.mit.edu	37	10	120925084	120925084	+	Nonsense_Mutation	SNP	C	C	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr10:120925084C>A	ENST00000355697.2	-	1	95	c.76G>T	c.(76-78)Gag>Tag	p.E26*	SFXN4_ENST00000461438.1_5'UTR|SFXN4_ENST00000330036.6_Nonsense_Mutation_p.E26*	NM_213649.1	NP_998814.1	Q6P4A7	SFXN4_HUMAN	sideroflexin 4	26					iron ion homeostasis	integral to membrane|mitochondrial membrane	cation transmembrane transporter activity			central_nervous_system(1)|cervix(1)|kidney(3)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	11		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0261)		ACGTTGGGCTCAATGAAGGCG	0.701000													12	26					4.3838e-07	4.60299e-07	1	1	0
LEMD2	221496	broad.mit.edu	37	6	33740447	33740447	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr6:33740447C>G	ENST00000293760.5	-	9	1489	c.1470G>C	c.(1468-1470)tgG>tgC	p.W490C	LEMD2_ENST00000508327.1_Missense_Mutation_p.W188C	NM_181336.3	NP_851853.1	Q8NC56	LEMD2_HUMAN	LEM domain containing 2	490						integral to nuclear inner membrane				central_nervous_system(2)|endometrium(3)|large_intestine(1)|lung(2)|pancreas(1)	9						TAGTCCATCTCCACACCAGCA	0.622000													35	37					0	0	1	0	0
KRT7	3855	broad.mit.edu	37	12	52627328	52627328	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr12:52627328C>G	ENST00000331817.5	+	1	431	c.248C>G	c.(247-249)tCc>tGc	p.S83C		NM_005556.3	NP_005547.3	P08729	K2C7_HUMAN	keratin 7	83	Head.			SL -> FS (in Ref. 3; CAB41416).	cytoskeleton organization|DNA replication|interphase|interspecies interaction between organisms|regulation of translation	Golgi apparatus|keratin filament|nucleus	protein binding|structural molecule activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|prostate(2)|stomach(1)|urinary_tract(1)	14				BRCA - Breast invasive adenocarcinoma(357;0.105)		GCCGACCCCTCCCTCCAGCGG	0.677000													16	64					0	0	1	0	0
LAMA2	3908	broad.mit.edu	37	6	129380937	129380937	+	Missense_Mutation	SNP	C	C	T	rs140199131		TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr6:129380937C>T	ENST00000421865.2	+	3	341	c.292C>T	c.(292-294)Ccg>Tcg	p.P98S		NM_000426.3|NM_001079823.1	NP_000417|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	98	Laminin N-terminal.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		AGAGAGACACCCGATTACAAA	0.328000													9	44					0	0	1	0	0
ARID1A	8289	broad.mit.edu	37	1	27100375	27100375	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr1:27100375C>T	ENST00000324856.7	+	17	4458	c.4087C>T	c.(4087-4089)Caa>Taa	p.Q1363*	ARID1A_ENST00000457599.2_Nonsense_Mutation_p.Q1363*|ARID1A_ENST00000540690.1_5'UTR|ARID1A_ENST00000374152.2_Nonsense_Mutation_p.Q980*	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	1363	Gln-rich.				androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding		ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		TACAATGTATCAACAGCAACA	0.488000			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								121	96					0	0	1	0	0
PRCP	5547	broad.mit.edu	37	11	82611320	82611320	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr11:82611320G>C	ENST00000313010.3	-	1	319	c.125C>G	c.(124-126)cCg>cGg	p.P42R	PRCP_ENST00000535099.1_Intron|PRCP_ENST00000393399.2_Missense_Mutation_p.P42R	NM_005040.2	NP_005031.1	P42785	PCP_HUMAN	prolylcarboxypeptidase (angiotensinase C)	42					blood coagulation, intrinsic pathway|proteolysis	lysosome|plasma membrane	protein binding|serine-type carboxypeptidase activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(7)|prostate(1)|skin(2)|urinary_tract(1)	17						GGCTACAGCCGGGAGGGATGT	0.637000													13	85					0	0	1	0	0
MYH6	4624	broad.mit.edu	37	14	23866174	23866174	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr14:23866174C>A	ENST00000405093.3	-	18	2236	c.2166G>T	c.(2164-2166)caG>caT	p.Q722H	MYH6_ENST00000356287.3_Missense_Mutation_p.Q722H	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	722	Myosin head-like.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		ATACCCACCTCTGCCGGAAGT	0.627000													22	60					8.88839e-20	9.7598e-20	1	1	0
KIAA0319	9856	broad.mit.edu	37	6	24596319	24596319	+	Missense_Mutation	SNP	A	A	G			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr6:24596319A>G	ENST00000535378.1	-	4	1198	c.556T>C	c.(556-558)Ttc>Ctc	p.F186L	KIAA0319_ENST00000543707.1_Missense_Mutation_p.F195L|KIAA0319_ENST00000378214.3_Missense_Mutation_p.F195L|KIAA0319_ENST00000430948.2_Missense_Mutation_p.F150L|KIAA0319_ENST00000537886.1_Missense_Mutation_p.F195L	NM_001168374.1	NP_001161846.1	Q5VV43	K0319_HUMAN	KIAA0319	195					negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			breast(3)|endometrium(6)|kidney(3)|large_intestine(11)|lung(19)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	53						GAGGAGTTGAAGGCCCCCTCG	0.632000													13	23					0	0	1	0	0
CYP3A7	1551	broad.mit.edu	37	7	99314836	99314836	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr7:99314836C>T	ENST00000336374.2	-	6	487	c.485G>A	c.(484-486)cGg>cAg	p.R162Q		NM_000765.3	NP_000756.2	P24462	CP3A7_HUMAN	cytochrome P450, family 3, subfamily A, polypeptide 7	162					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			autonomic_ganglia(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	32	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)					CTCTGCTTCCCGCCTCAGATT	0.502000													26	104					0	0	1	0	0
CRMP1	1400	broad.mit.edu	37	4	5837699	5837699	+	Silent	SNP	G	G	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr4:5837699G>A	ENST00000324989.7	-	11	1654	c.1566C>T	c.(1564-1566)gaC>gaT	p.D522D	CRMP1_ENST00000512574.1_Silent_p.D406D|CRMP1_ENST00000397890.2_Silent_p.D408D|CRMP1_ENST00000511535.1_5'UTR	NM_001014809.1	NP_001014809.1	Q14194	DPYL1_HUMAN	collapsin response mediator protein 1	408					axon guidance|pyrimidine base catabolic process	cytosol|microtubule organizing center|spindle	dihydropyrimidinase activity|protein binding			NS(1)|cervix(2)|endometrium(4)|large_intestine(10)|lung(11)|ovary(2)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	36				Colorectal(103;0.0721)		AGATGACCACGTCGGCATCCG	0.517000													33	84					0	0	1	0	0
CCDC78	124093	broad.mit.edu	37	16	775266	775266	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr16:775266C>T	ENST00000293889.6	-	5	568	c.463G>A	c.(463-465)Gag>Aag	p.E155K		NM_001031737.2	NP_001026907.2	A2IDD5	CCD78_HUMAN	coiled-coil domain containing 78	155										central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|lung(2)|skin(3)	9		Hepatocellular(780;0.0218)				TGCTCATTCTCGGGGTTCATG	0.627000													22	108					0	0	1	0	0
NOL8	55035	broad.mit.edu	37	9	95081520	95081520	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr9:95081520C>T	ENST00000545558.1	-	5	892	c.400G>A	c.(400-402)Gaa>Aaa	p.E134K	NOL8_ENST00000442668.2_Missense_Mutation_p.E134K|NOL8_ENST00000542053.1_Missense_Mutation_p.E66K|NOL8_ENST00000535387.1_Missense_Mutation_p.E134K|NOL8_ENST00000358855.4_Missense_Mutation_p.E66K			Q76FK4	NOL8_HUMAN	nucleolar protein 8	134					DNA replication|positive regulation of cell growth	nucleolus	nucleotide binding|protein binding|RNA binding			endometrium(3)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)	16						CCTGGCACTTCTGTCCCTGGC	0.463000													12	30					0	0	1	0	0
C11orf16	56673	broad.mit.edu	37	11	8947502	8947502	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr11:8947502G>A	ENST00000326053.5	-	5	818	c.712C>T	c.(712-714)Cac>Tac	p.H238Y	C11orf16_ENST00000525780.1_Missense_Mutation_p.H238Y	NM_020643.2	NP_065694.2	Q9NQ32	CK016_HUMAN	chromosome 11 open reading frame 16	238										central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)	22				Epithelial(150;4.11e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0234)		GGGGCCCAGTGAAGGGGCCTG	0.607000													10	88					0	0	1	0	0
OR2T12	127064	broad.mit.edu	37	1	248458734	248458734	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr1:248458734C>A	ENST00000317996.1	-	1	146	c.147G>T	c.(145-147)tgG>tgT	p.W49C		NM_001004692.1	NP_001004692.1	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T, member 12	49					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(3)|large_intestine(3)|lung(25)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	43	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			GCCGGTGGTCCCAGTGAATCA	0.537000													22	33					8.44121e-28	9.45415e-28	1	1	0
CD97	976	broad.mit.edu	37	19	14512345	14512345	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr19:14512345C>T	ENST00000242786.5	+	10	1125	c.1045C>T	c.(1045-1047)Ccc>Tcc	p.P349S	CD97_ENST00000357355.3_Missense_Mutation_p.P300S|CD97_ENST00000358600.3_Missense_Mutation_p.P256S	NM_078481.3	NP_510966.1	P48960	CD97_HUMAN	CD97 molecule	349					cell adhesion|cell-cell signaling|cellular component movement|immune response|inflammatory response|neuropeptide signaling pathway	extracellular space|integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|liver(1)|lung(9)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30						GCCTAAAGGCCCCTTCACCTA	0.612000													11	71					0	0	1	0	0
CREBBP	1387	broad.mit.edu	37	16	3779153	3779153	+	Silent	SNP	C	C	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr16:3779153C>T	ENST00000262367.5	-	31	6704	c.5895G>A	c.(5893-5895)gaG>gaA	p.E1965E	CREBBP_ENST00000382070.3_Silent_p.E1927E	NM_004380.2	NP_004371.2	Q92793	CBP_HUMAN	CREB binding protein	1965					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(4)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(125)|kidney(5)|large_intestine(32)|lung(43)|ovary(18)|pancreas(2)|prostate(6)|skin(9)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(21)	295		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		GCTGCTGGGCCTCACGCTCGA	0.711000			"""T, N, F, Mis, O"""	"""MLL, MORF, RUNXBP2"""	"""ALL, AML, DLBCL, B-NHL """		Rubinstein-Taybi syndrome						3	6					0	0	1	0	0
ZNF728	388523	broad.mit.edu	37	19	23170128	23170128	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr19:23170128G>C	ENST00000594710.1	-	3	353	c.208C>G	c.(208-210)Ctg>Gtg	p.L70V		NM_001267716.1	NP_001254645.1			zinc finger protein 728																		TCTTTCACCAGCTCATGTCTC	0.438000													16	53					0	0	1	0	0
WASH2P	375260	broad.mit.edu	37	2	114356313	114356313	+	RNA	SNP	C	C	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr2:114356313C>A	ENST00000538033.2	+	0	2493																											GACTGGGAATCCTAGGGGGCT	0.647000													3	27					1	1	1	1	0
KDM3B	51780	broad.mit.edu	37	5	137761242	137761242	+	Missense_Mutation	SNP	A	A	G			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr5:137761242A>G	ENST00000314358.5	+	17	4582	c.4382A>G	c.(4381-4383)gAt>gGt	p.D1461G	KDM3B_ENST00000542866.1_Missense_Mutation_p.D493G|KDM3B_ENST00000394866.1_Missense_Mutation_p.D1117G	NM_016604.3	NP_057688	Q7LBC6	KDM3B_HUMAN	lysine (K)-specific demethylase 3B	1461					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(15)|liver(2)|lung(18)|ovary(4)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	65						AAAGTTCGGGATTTCTGGGAT	0.453000													51	43					0	0	1	0	0
PDGFRA	5156	broad.mit.edu	37	4	55140704	55140704	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr4:55140704G>A	ENST00000257290.5	+	11	1896	c.1565G>A	c.(1564-1566)cGt>cAt	p.R522H	FIP1L1_ENST00000507166.1_Intron	NM_006206.4	NP_006197.1	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor, alpha polypeptide	522					cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			NS(1)|autonomic_ganglia(1)|bone(1)|breast(4)|central_nervous_system(17)|cervix(1)|endometrium(4)|eye(1)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(22)|kidney(6)|large_intestine(26)|liver(4)|lung(48)|ovary(4)|prostate(6)|skin(11)|small_intestine(49)|soft_tissue(727)|stomach(32)|urinary_tract(1)	967	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	GTAGCCCTGCGTTCTGAACTC	0.498000			"""Mis, O, T"""	FIP1L1	"""GIST, idiopathic hypereosinophilic syndrome, paediatric GBM"""				Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Intestinal Neurofibromatosis	TSP Lung(21;0.16)			27	83					0	0	1	0	0
ROR1	4919	broad.mit.edu	37	1	64643579	64643579	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr1:64643579C>T	ENST00000371079.1	+	9	2230	c.1855C>T	c.(1855-1857)Cgc>Tgc	p.R619C	ROR1_ENST00000545203.1_Missense_Mutation_p.R70C	NM_005012.3	NP_005003.2	Q01973	ROR1_HUMAN	receptor tyrosine kinase-like orphan receptor 1	619	Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	cytoplasm|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			breast(7)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(14)|lung(10)|ovary(6)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	51						CCTTGCAGCTCGCAATATTTT	0.453000													13	28					0	0	1	0	0
SORBS2	8470	broad.mit.edu	37	4	186545479	186545479	+	Silent	SNP	G	G	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr4:186545479G>A	ENST00000431808.1	-	14	1655	c.1092C>T	c.(1090-1092)aaC>aaT	p.N364N	SORBS2_ENST00000393528.3_Intron|SORBS2_ENST00000498125.1_Intron|SORBS2_ENST00000355634.5_Silent_p.N464N|SORBS2_ENST00000449407.2_Intron|SORBS2_ENST00000319471.9_Intron|SORBS2_ENST00000284776.7_Silent_p.N364N|SORBS2_ENST00000437304.2_Intron|SORBS2_ENST00000418609.1_Silent_p.N268N|SORBS2_ENST00000448662.2_Intron			O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2	364						actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(9)|lung(21)|ovary(2)|prostate(2)|skin(4)|urinary_tract(1)	53		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		AGATTTCTGCGTTTTGCCGGG	0.517000													3	55					0	0	1	0	0
KL	9365	broad.mit.edu	37	13	33635874	33635874	+	Silent	SNP	G	G	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr13:33635874G>A	ENST00000380099.3	+	4	2666	c.2658G>A	c.(2656-2658)ctG>ctA	p.L886L	KL_ENST00000487852.1_3'UTR	NM_004795.3	NP_004786.2	Q9UEF7	KLOT_HUMAN	klotho	886	Glycosyl hydrolase-1 2.				aging|carbohydrate metabolic process|insulin receptor signaling pathway|positive regulation of bone mineralization	extracellular space|integral to membrane|integral to plasma membrane|membrane fraction|soluble fraction	beta-glucosidase activity|beta-glucuronidase activity|cation binding|fibroblast growth factor binding|hormone activity|signal transducer activity|vitamin D binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(10)|lung(14)|ovary(2)|skin(5)	41	all_epithelial(80;0.133)	Ovarian(182;1.78e-06)|Breast(139;4.08e-05)|Hepatocellular(188;0.00886)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;7.13e-230)|all cancers(112;1.33e-165)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-113)|Epithelial(112;3.79e-112)|Lung(94;8.52e-27)|LUSC - Lung squamous cell carcinoma(192;1.4e-13)|Kidney(163;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(186;5.63e-08)|BRCA - Breast invasive adenocarcinoma(63;1.41e-05)		ACGACCAGCTGAGGGTGTATT	0.488000													18	67					0	0	1	0	0
NIN	51199	broad.mit.edu	37	14	51210232	51210232	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr14:51210232G>C	ENST00000245441.5	-	24	5393	c.5203C>G	c.(5203-5205)Ctt>Gtt	p.L1735V	NIN_ENST00000324330.9_Missense_Mutation_p.L1735V|NIN_ENST00000453196.1_Missense_Mutation_p.L1735V|NIN_ENST00000530997.2_Missense_Mutation_p.L1735V|NIN_ENST00000389868.3_Missense_Mutation_p.L1022V|NIN_ENST00000382043.4_Missense_Mutation_p.L1022V|NIN_ENST00000382041.3_Missense_Mutation_p.L1735V	NM_020921.3	NP_065972	Q8N4C6	NIN_HUMAN	ninein (GSK3B interacting protein)	1735					centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(10)|kidney(5)|large_intestine(13)|lung(16)|ovary(1)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	71	all_epithelial(31;0.00244)|Breast(41;0.127)					TGCTCTAAAAGACTTGATTTT	0.423000			T	PDGFRB	MPD								10	21					0	0	1	0	0
PARK2	5071	broad.mit.edu	37	6	162864342	162864342	+	Splice_Site	SNP	C	C	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr6:162864342C>T	ENST00000366898.1	-	2	273	c.171G>A	c.(169-171)caG>caA	p.Q57Q	PARK2_ENST00000366897.1_Splice_Site_p.Q57Q|PARK2_ENST00000366892.1_Splice_Site_p.Q57Q|PARK2_ENST00000366896.1_Splice_Site_p.Q57Q|PARK2_ENST00000338468.3_5'UTR|PARK2_ENST00000366894.1_5'UTR	NM_004562.2	NP_004553.2	O60260	PRKN2_HUMAN	parkin RBR E3 ubiquitin protein ligase	57	Ubiquitin-like.				aggresome assembly|central nervous system development|mitochondrion degradation|negative regulation of actin filament bundle assembly|negative regulation of cell death|negative regulation of protein phosphorylation|negative regulation of release of cytochrome c from mitochondria|neuron death|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autoubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein monoubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of autophagy|regulation of reactive oxygen species metabolic process	aggresome|cytosol|endoplasmic reticulum|Golgi apparatus|mitochondrion|nucleus|perinuclear region of cytoplasm	chaperone binding|PDZ domain binding|protein kinase binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(21)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	39		all_cancers(1;8.13e-65)|all_epithelial(1;5.77e-64)|Colorectal(1;9.65e-15)|all_lung(1;1.66e-13)|Lung NSC(1;7.54e-11)|Melanoma(1;1.75e-09)|Breast(66;7.81e-05)|Ovarian(120;0.000981)|Prostate(117;0.0288)|Esophageal squamous(34;0.102)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0663)|all cancers(1;1.9e-63)|Epithelial(1;1.5e-59)|Colorectal(1;2.16e-23)|OV - Ovarian serous cystadenocarcinoma(65;3.53e-20)|COAD - Colon adenocarcinoma(1;2.11e-15)|STAD - Stomach adenocarcinoma(1;4.64e-07)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|READ - Rectum adenocarcinoma(1;2.95e-06)|GBM - Glioblastoma multiforme(2;7.23e-06)|Lung(1;0.00163)|KIRC - Kidney renal clear cell carcinoma(4;0.00371)|LUSC - Lung squamous cell carcinoma(1;0.00442)|Kidney(4;0.0046)		GGAGACTCACCTGCACAGTCC	0.567000													15	53					0	0	1	0	0
DPY19L2P2	349152	broad.mit.edu	37	7	102825946	102825946	+	RNA	SNP	C	C	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr7:102825946C>T	ENST00000312132.4	-	0	3751																											GACAGCTTGACACTTGCCATT	0.373000													4	75					0	0	1	0	0
XAGE5	170627	broad.mit.edu	37	X	52844174	52844174	+	Silent	SNP	C	C	T	rs146352090		TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chrX:52844174C>T	ENST00000351072.1	+	4	303	c.237C>T	c.(235-237)tgC>tgT	p.C79C	XAGE5_ENST00000375501.1_Silent_p.C79C|XAGE5_ENST00000425386.1_Silent_p.C79C|XAGE5_ENST00000375503.3_3'UTR|XAGE5_ENST00000445860.2_3'UTR			Q8WWM1	GAGD5_HUMAN	X antigen family, member 5	79										endometrium(1)|large_intestine(1)|lung(5)|ovary(1)	8						GGGATGAATGCGGAGATAGTC	0.438000													26	47					0	0	1	0	0
UBBP4	23666	broad.mit.edu	37	17	21730847	21730847	+	Missense_Mutation	SNP	G	G	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr17:21730847G>T	ENST00000584755.1	+	2	546	c.149G>T	c.(148-150)cGg>cTg	p.R50L	UBBP4_ENST00000583708.1_Intron|UBBP4_ENST00000578713.1_Missense_Mutation_p.R50L|UBBP4_ENST00000584398.1_Intron																endometrium(9)|kidney(4)|lung(4)|prostate(3)|urinary_tract(4)	24						GGCAAGCAGCGGGAAGATGGC	0.522000													4	48					0.150653	0.153393	1	1	0
ZNF534	147658	broad.mit.edu	37	19	52954586	52954586	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr19:52954586G>A	ENST00000301085.4	+	5	543	c.418G>A	c.(418-420)Gtt>Att	p.V140I	ZNF534_ENST00000432303.2_Missense_Mutation_p.V97I			Q76KX8	ZN534_HUMAN	zinc finger protein 534	0					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|lung(1)|prostate(1)|skin(1)	4						ATTTCCTTCCGTTTCTGCTTC	0.682000													4	8					0	0	1	0	0
ADAMTS10	81794	broad.mit.edu	37	19	8665902	8665902	+	Silent	SNP	G	G	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr19:8665902G>A	ENST00000270328.4	-	5	986	c.720C>T	c.(718-720)taC>taT	p.Y240Y	ADAMTS10_ENST00000596709.1_5'UTR|ADAMTS10_ENST00000597188.1_Silent_p.Y240Y			Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 10	240	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(16)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(3)|skin(10)|urinary_tract(1)	53						GGGTCTCCACGTAGCGCTCTC	0.622000													35	104					0	0	1	0	0
FAM135A	57579	broad.mit.edu	37	6	71234834	71234834	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr6:71234834C>T	ENST00000418814.2	+	15	2661	c.2047C>T	c.(2047-2049)Cga>Tga	p.R683*	FAM135A_ENST00000505769.1_Nonsense_Mutation_p.R487*|FAM135A_ENST00000457062.2_Nonsense_Mutation_p.R470*|FAM135A_ENST00000505868.1_Nonsense_Mutation_p.R683*|FAM135A_ENST00000370479.3_Nonsense_Mutation_p.R470*|FAM135A_ENST00000361499.3_Nonsense_Mutation_p.R487*	NM_001105531.2|NM_001162529.1	NP_001099001.1|NP_001156001.1	Q9P2D6	F135A_HUMAN	family with sequence similarity 135, member A	683										breast(2)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	38						GACAGAGCTTCGACAAGAGGA	0.353000													34	42					0	0	1	0	0
AASS	10157	broad.mit.edu	37	7	121741434	121741434	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr7:121741434C>T	ENST00000393376.1	-	12	1492	c.1397G>A	c.(1396-1398)cGg>cAg	p.R466Q	AASS_ENST00000417368.2_Missense_Mutation_p.R466Q|AASS_ENST00000473553.1_5'UTR			Q9UDR5	AASS_HUMAN	aminoadipate-semialdehyde synthase	466					protein tetramerization	mitochondrial matrix	binding|saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity|saccharopine dehydrogenase (NADP+, L-lysine-forming) activity			autonomic_ganglia(1)|breast(2)|endometrium(3)|kidney(6)|large_intestine(12)|lung(27)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	54					L-Glutamic Acid(DB00142)|NADH(DB00157)	CCTGCTCTCCCGGAGTGTCTG	0.318000													17	59					0	0	1	0	0
NUP210	23225	broad.mit.edu	37	3	13376966	13376966	+	Silent	SNP	C	C	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr3:13376966C>T	ENST00000254508.5	-	28	3913	c.3831G>A	c.(3829-3831)gaG>gaA	p.E1277E		NM_024923.2	NP_079199.2	Q8TEM1	PO210_HUMAN	nucleoporin 210kDa	1277					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|liver(1)|lung(16)|ovary(7)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	66	all_neural(104;0.187)					GGACTTGGATCTCATCCGAGA	0.627000													25	184					0	0	1	0	0
VPS13B	157680	broad.mit.edu	37	8	100865842	100865842	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr8:100865842G>A	ENST00000358544.2	+	56	10411	c.10300G>A	c.(10300-10302)Gag>Aag	p.E3434K	VPS13B_ENST00000395996.1_3'UTR|VPS13B_ENST00000357162.2_Missense_Mutation_p.E3409K	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	3434					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			CCCTGGGGAAGAGCCTGTGGC	0.527000													45	58					0	0	1	0	0
FAM19A1	407738	broad.mit.edu	37	3	68466476	68466476	+	Silent	SNP	G	G	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr3:68466476G>A	ENST00000478136.1	+	3	655	c.165G>A	c.(163-165)aaG>aaA	p.K55K	FAM19A1_ENST00000496687.1_Silent_p.K55K|FAM19A1_ENST00000491017.1_3'UTR	NM_213609.3	NP_998774.2	Q7Z5A9	F19A1_HUMAN	family with sequence similarity 19 (chemokine (C-C motif)-like), member A1	55						endoplasmic reticulum|extracellular region				central_nervous_system(1)|endometrium(1)|kidney(1)|lung(3)|ovary(1)	7		Lung NSC(201;0.0117)		BRCA - Breast invasive adenocarcinoma(55;7.7e-05)|Epithelial(33;0.000937)|KIRC - Kidney renal clear cell carcinoma(39;0.0579)|Kidney(39;0.0743)		GTTGTAACAAGAATCGCATTG	0.468000													27	41					0	0	1	0	0
TPP2	7174	broad.mit.edu	37	13	103326724	103326724	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr13:103326724G>A	ENST00000376052.3	+	28	3479	c.3463G>A	c.(3463-3465)Gac>Aac	p.D1155N	TPP2_ENST00000376065.4_Missense_Mutation_p.D1142N|TPP2_ENST00000466153.1_3'UTR			P29144	TPP2_HUMAN	tripeptidyl peptidase II	1142					proteolysis	cytoplasm|nucleus	aminopeptidase activity|serine-type endopeptidase activity|tripeptidyl-peptidase activity			breast(2)|endometrium(5)|kidney(2)|large_intestine(12)|lung(21)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	52	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					CCAGGCTCAAGACGGAGCCAT	0.478000													24	39					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	8996396	8996396	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr19:8996396C>G	ENST00000397910.4	-	61	41379	c.41176G>C	c.(41176-41178)Gag>Cag	p.E13726Q	MUC16_ENST00000380951.5_Missense_Mutation_p.E367Q	NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	13728	SEA 11.			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGGCTCAGCTCCCAATACAGC	0.567000													54	108					0	0	1	0	0
PCDHGA8	9708	broad.mit.edu	37	5	140774130	140774130	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr5:140774130C>T	ENST00000398604.2	+	1	1750	c.1750C>T	c.(1750-1752)Cgt>Tgt	p.R584C	PCDHGA5_ENST00000518069.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA4_ENST00000571252.1_Intron	NM_032088.1	NP_114477.1														endometrium(6)|kidney(6)|large_intestine(6)|lung(30)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	51			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCCGCAGAGCGTGGCTACCT	0.672000													47	146					0	0	1	0	0
NUP210	23225	broad.mit.edu	37	3	13377029	13377029	+	Silent	SNP	C	C	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr3:13377029C>T	ENST00000254508.5	-	28	3850	c.3768G>A	c.(3766-3768)gtG>gtA	p.V1256V		NM_024923.2	NP_079199.2	Q8TEM1	PO210_HUMAN	nucleoporin 210kDa	1256					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|liver(1)|lung(16)|ovary(7)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	66	all_neural(104;0.187)					CAGCCTTGACCACCACCCTCA	0.602000													8	112					0	0	1	0	0
B3GALT4	8705	broad.mit.edu	37	6	33245984	33245984	+	Nonsense_Mutation	SNP	C	C	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr6:33245984C>A	ENST00000451237.1	+	1	1068	c.788C>A	c.(787-789)tCa>tAa	p.S263*		NM_003782.3	NP_003773.1	O96024	B3GT4_HUMAN	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4	263					protein glycosylation	Golgi membrane|integral to membrane	ganglioside galactosyltransferase activity|UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|pancreas(1)|prostate(1)|soft_tissue(1)|urinary_tract(2)	13						CCCTATGCCTCAGGCACGGGG	0.637000													30	39					2.47511e-08	2.6655e-08	1	1	0
DCC	1630	broad.mit.edu	37	18	50731606	50731606	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr18:50731606G>A	ENST00000442544.2	+	10	2210	c.1594G>A	c.(1594-1596)Gaa>Aaa	p.E532K	DCC_ENST00000412726.1_Missense_Mutation_p.E380K|DCC_ENST00000581580.1_Missense_Mutation_p.E187K	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	532	Fibronectin type-III 2.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		AGGGCCAGTAGAAAACCTGCA	0.388000													47	163					0	0	1	0	0
ZNF414	84330	broad.mit.edu	37	19	8576365	8576365	+	Silent	SNP	C	C	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr19:8576365C>T	ENST00000255616.8	-	6	1031	c.930G>A	c.(928-930)gcG>gcA	p.A310A	ZNF414_ENST00000393927.4_Intron	NM_032370.2	NP_115746.2	Q96IQ9	ZN414_HUMAN	zinc finger protein 414	310					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			lung(2)	2						GTCACCTGCACGCACCTGAGG	0.687000													10	21					0	0	1	0	0
CLCN4	1183	broad.mit.edu	37	X	10188760	10188760	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chrX:10188760G>A	ENST00000380833.4	+	12	2426	c.2035G>A	c.(2035-2037)Gaa>Aaa	p.E679K	CLCN4_ENST00000421085.2_Missense_Mutation_p.E585K|CLCN4_ENST00000380829.1_Missense_Mutation_p.E648K	NM_001256944.1|NM_001830.3	NP_001243873.1|NP_001821.2	P51793	CLCN4_HUMAN	chloride channel, voltage-sensitive 4	679						early endosome membrane|integral to membrane|late endosome membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(11)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						CTTCACGGAGGAACCCCCCGA	0.567000													109	35					0	0	1	0	0
HIST1H1E	3008	broad.mit.edu	37	6	26156830	26156830	+	Missense_Mutation	SNP	A	A	G			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr6:26156830A>G	ENST00000304218.3	+	1	272	c.212A>G	c.(211-213)tAt>tGt	p.Y71C		NM_005321.2	NP_005312.1	P10412	H14_HUMAN	histone cluster 1, H1e	71	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			NS(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(1)|liver(1)|lung(9)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	26						GCCGCTGGCTATGACGTGGAG	0.627000													15	30					0	0	1	0	0
ALDH8A1	64577	broad.mit.edu	37	6	135263702	135263702	+	Splice_Site	SNP	C	C	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr6:135263702C>T	ENST00000265605.2	-	3	355	c.287G>A	c.(286-288)gGg>gAg	p.G96E	ALDH8A1_ENST00000367845.2_Splice_Site_p.G96E|ALDH8A1_ENST00000367847.2_Splice_Site_p.G96E	NM_022568.3	NP_072090.1	Q9H2A2	AL8A1_HUMAN	aldehyde dehydrogenase 8 family, member A1	96					retinal metabolic process	cytoplasm	retinal dehydrogenase activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	36	Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.00401)|GBM - Glioblastoma multiforme(68;0.0058)		TAAGGTTTTCCCTGTAAGAAG	0.522000													18	573					0	0	1	0	0
CGNL1	84952	broad.mit.edu	37	15	57730261	57730261	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr15:57730261G>A	ENST00000281282.5	+	2	142	c.64G>A	c.(64-66)Gca>Aca	p.A22T		NM_001252335.1|NM_032866.4	NP_001239264.1|NP_116255.2	Q0VF96	CGNL1_HUMAN	cingulin-like 1	22	Head.					myosin complex|tight junction	motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(14)|ovary(4)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)	60				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		TCTGAGACTCGCAAGTGATGA	0.493000													70	179					0	0	1	0	0
HCAR2	338442	broad.mit.edu	37	12	123186957	123186957	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr12:123186957C>T	ENST00000328880.5	-	1	933	c.874G>A	c.(874-876)Gtg>Atg	p.V292M	HCAR1_ENST00000356987.2_Intron|RP11-324E6.6_ENST00000543611.1_lincRNA	NM_177551.3	NP_808219.1	Q8TDS4	HCAR2_HUMAN	hydroxycarboxylic acid receptor 2	292					negative regulation of lipid catabolic process|neutrophil apoptosis|positive regulation of adiponectin secretion|positive regulation of neutrophil apoptosis	integral to membrane|plasma membrane	nicotinic acid receptor activity|purinergic nucleotide receptor activity, G-protein coupled			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(5)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	15					Mepenzolate(DB04843)|Niacin(DB00627)	TAGTACACCACGGGGTCCAGC	0.527000													4	44					0	0	1	0	0
NUP210	23225	broad.mit.edu	37	3	13377022	13377022	+	Missense_Mutation	SNP	C	C	T	rs146409293		TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr3:13377022C>T	ENST00000254508.5	-	28	3857	c.3775G>A	c.(3775-3777)Gct>Act	p.A1259T		NM_024923.2	NP_079199.2	Q8TEM1	PO210_HUMAN	nucleoporin 210kDa	1259					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|liver(1)|lung(16)|ovary(7)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	66	all_neural(104;0.187)					GGGTCCACAGCCTTGACCACC	0.617000													9	110					0	0	1	0	0
MRGPRE	116534	broad.mit.edu	37	11	3249921	3249921	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr11:3249921C>T	ENST00000389832.5	-	2	415	c.109G>A	c.(109-111)Ggt>Agt	p.G37S	MRGPRE_ENST00000436689.2_Missense_Mutation_p.G36S|AC109309.4_ENST00000418995.2_RNA			Q86SM8	MRGRE_HUMAN	MAS-related GPR, member E	36						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|liver(1)|lung(6)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	19		Medulloblastoma(188;0.00106)|all_epithelial(84;0.00111)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00529)|LUSC - Lung squamous cell carcinoma(625;0.19)		AGCAGCCCACCGAGGCCGAGC	0.652000													9	76					0	0	1	0	0
SLC45A4	57210	broad.mit.edu	37	8	142229828	142229828	+	Silent	SNP	C	C	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr8:142229828C>A	ENST00000519067.1	-	3	681	c.378G>T	c.(376-378)ggG>ggT	p.G126G	SLC45A4_ENST00000517878.1_Silent_p.G177G|SLC45A4_ENST00000024061.3_Silent_p.G126G|SLC45A4_ENST00000433583.2_Silent_p.G119G			Q5BKX6	S45A4_HUMAN	solute carrier family 45, member 4	177					transport	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			CACGGATGGGCCCCTCGGTGG	0.662000													6	31					0.0293803	0.0300969	1	1	0
ZNF529	57711	broad.mit.edu	37	19	37038913	37038913	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr19:37038913C>T	ENST00000334116.7	-	6	842	c.232G>A	c.(232-234)Gac>Aac	p.D78N	ZNF529_ENST00000591340.1_Missense_Mutation_p.D183N	NM_001145650.1	NP_001139122.1	Q6P280	ZN529_HUMAN	zinc finger protein 529	150	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1	Esophageal squamous(110;0.198)					AACTCTAAGTCACAACTGAAG	0.363000													23	24					0	0	1	0	0
PRPF40B	25766	broad.mit.edu	37	12	50026812	50026812	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr12:50026812G>A	ENST00000261897.1	+	6	831	c.280G>A	c.(280-282)Gag>Aag	p.E94K	PRPF40B_ENST00000380281.1_Missense_Mutation_p.E100K|PRPF40B_ENST00000548825.2_Missense_Mutation_p.E122K			Q6NWY9	PR40B_HUMAN	PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae)	100	WW 1.				mRNA processing|RNA splicing	nuclear speck				breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	34						CCTATGGAGTGAGCATGTGGC	0.582000													4	10					0	0	1	0	0
FRYL	285527	broad.mit.edu	37	4	48549697	48549697	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr4:48549697G>A	ENST00000537810.1	-	41	5582	c.4978C>T	c.(4978-4980)Cga>Tga	p.R1660*	FRYL_ENST00000264319.7_5'UTR|FRYL_ENST00000503238.1_Nonsense_Mutation_p.R1660*|FRYL_ENST00000358350.4_Nonsense_Mutation_p.R1660*|FRYL_ENST00000507873.2_5'UTR			O94915	FRYL_HUMAN	FRY-like	1660					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(21)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	91						GCAACAGTTCGGATGTTACTA	0.418000													12	37					0	0	1	0	0
POU4F1	5457	broad.mit.edu	37	13	79175873	79175873	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr13:79175873C>T	ENST00000377208.5	-	2	1148	c.937G>A	c.(937-939)Gag>Aag	p.E313K	RNF219-AS1_ENST00000430549.2_RNA|RNF219-AS1_ENST00000607205.1_RNA|RNF219-AS1_ENST00000606376.1_RNA|RNF219-AS1_ENST00000606124.1_RNA|RNF219-AS1_ENST00000606429.1_RNA|RNF219-AS1_ENST00000607220.1_RNA|RNF219-AS1_ENST00000607860.1_RNA|RNF219-AS1_ENST00000560584.2_RNA|RNF219-AS1_ENST00000444769.3_RNA|RNF219-AS1_ENST00000560209.2_RNA	NM_006237.3	NP_006228.3	Q01851	PO4F1_HUMAN	POU class 4 homeobox 1	313	POU-specific.				axonogenesis|regulation of transcription from RNA polymerase II promoter|synapse assembly	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|cervix(1)|endometrium(4)|large_intestine(4)|lung(5)|ovary(1)	16		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.0848)		GBM - Glioblastoma multiforme(99;0.129)		GTGAGCGACTCGAACCTGCAG	0.647000													6	18					0	0	1	0	0
MAPK11	5600	broad.mit.edu	37	22	50705688	50705688	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr22:50705688G>A	ENST00000330651.6	-	5	545	c.445C>T	c.(445-447)Cgg>Tgg	p.R149W	MAPK11_ENST00000495277.1_5'UTR|MAPK11_ENST00000449719.2_Missense_Mutation_p.R41W	NM_002751.5	NP_002742.3	Q15759	MK11_HUMAN	mitogen-activated protein kinase 11	149	Protein kinase.				activation of MAPK activity|innate immune response|mRNA metabolic process|muscle cell differentiation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of muscle cell differentiation|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|protein binding			breast(1)|central_nervous_system(1)|lung(4)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GCACCTACCCGGTGGATGATC	0.721000													4	22					0	0	1	0	0
CEACAM4	1089	broad.mit.edu	37	19	42131981	42131981	+	Missense_Mutation	SNP	C	C	T	rs118076769	byFrequency	TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr19:42131981C>T	ENST00000221954.2	-	2	528	c.418G>A	c.(418-420)Gta>Ata	p.V140I	CEACAM4_ENST00000600925.1_Missense_Mutation_p.V140I	NM_001817.2	NP_001808.2	O75871	CEAM4_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 4	140						integral to plasma membrane|membrane fraction				NS(1)|endometrium(1)|large_intestine(3)|lung(4)|prostate(3)|skin(3)|urinary_tract(1)	16						TCACGGTGTACGTGGAGCTGG	0.562000													39	199					0	0	1	0	0
CDHR5	53841	broad.mit.edu	37	11	617954	617954	+	Splice_Site	SNP	C	C	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr11:617954C>T	ENST00000358353.3	-	15	2440	c.2118G>A	c.(2116-2118)ccG>ccA	p.P706P	CDHR5_ENST00000397542.2_Splice_Site_p.P706P|CDHR5_ENST00000349570.7_Splice_Site_p.P512P			Q9HBB8	CDHR5_HUMAN	cadherin-related family member 5	706					calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|skin(2)	23						TGGGCCTCACCGGAGCTTTGC	0.672000													9	12					0	0	1	0	0
KCNJ2	3759	broad.mit.edu	37	17	68172154	68172154	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr17:68172154G>A	ENST00000243457.3	+	2	1357	c.974G>A	c.(973-975)cGc>cAc	p.R325H	KCNJ2_ENST00000535240.1_Missense_Mutation_p.R325H	NM_000891.2	NP_000882.1	P63252	IRK2_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 2	325					synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(13)|skin(1)|urinary_tract(1)	25	Breast(10;1.64e-08)					TGGGGCCACCGCTATGAGCCT	0.493000													12	57					0	0	1	0	0
VWF	7450	broad.mit.edu	37	12	6105241	6105241	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr12:6105241G>C	ENST00000261405.5	-	35	6244	c.5990C>G	c.(5989-5991)gCa>gGa	p.A1997G		NM_000552.3	NP_000543	P04275	VWF_HUMAN	von Willebrand factor	1997	VWFD 4.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	GCCCTGCCTTGCTCCAGGGCT	0.522000													14	24					0	0	1	0	0
SLC6A1	6529	broad.mit.edu	37	3	11058951	11058951	+	Silent	SNP	C	C	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr3:11058951C>T	ENST00000287766.4	+	3	475	c.54C>T	c.(52-54)agC>agT	p.S18S	SLC6A1_ENST00000462473.1_Intron|SLC6A1-AS1_ENST00000414969.2_RNA|SLC6A1_ENST00000536032.1_Intron	NM_003042.3	NP_003033.3	P30531	SC6A1_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 1	18					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(2)|large_intestine(6)|lung(6)|ovary(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)	26		Ovarian(110;0.0392)		OV - Ovarian serous cystadenocarcinoma(96;0.00099)	Cocaine(DB00907)|Tiagabine(DB00906)	CCGAGGTCAGCGAGGCCCCTG	0.637000													12	65					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167642176	167642176	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr5:167642176C>T	ENST00000519204.1	+	20	3732	c.3614C>T	c.(3613-3615)tCg>tTg	p.S1205L	TENM2_ENST00000518659.1_Missense_Mutation_p.S1326L|TENM2_ENST00000403607.2_Missense_Mutation_p.S1150L|TENM2_ENST00000520394.1_Missense_Mutation_p.S1087L|TENM2_ENST00000545108.1_Missense_Mutation_p.S1325L					teneurin transmembrane protein 2																		GCTGGGAATTCGGAAGTTGTG	0.592000													9	130					0	0	1	0	0
PLGRKT	55848	broad.mit.edu	37	9	5431965	5431965	+	Missense_Mutation	SNP	A	A	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr9:5431965A>T	ENST00000223864.2	-	3	234	c.13T>A	c.(13-15)Ttt>Att	p.F5I	PLGRKT_ENST00000482696.1_5'UTR	NM_018465.3	NP_060935.2	Q9HBL7	CI046_HUMAN	plasminogen receptor, C-terminal lysine transmembrane protein	5						integral to membrane											GATTTTGAAAATATAAACCCC	0.313000													5	5					0	0	1	0	0
PAPOLA	10914	broad.mit.edu	37	14	97003321	97003321	+	Missense_Mutation	SNP	A	A	G			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr14:97003321A>G	ENST00000216277.8	+	12	1259	c.1039A>G	c.(1039-1041)Atc>Gtc	p.I347V	PAPOLA_ENST00000392990.2_Missense_Mutation_p.I347V	NM_032632.4	NP_116021.2	P51003	PAPOA_HUMAN	poly(A) polymerase alpha	347					mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|RNA binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(6)|skin(1)|urinary_tract(1)	21		all_cancers(154;0.0555)|all_epithelial(191;0.149)|Melanoma(154;0.155)		COAD - Colon adenocarcinoma(157;0.213)		AGGTCTTGCTATCACAGATGA	0.308000													10	24					0	0	1	0	0
SPSB2	84727	broad.mit.edu	37	12	6981399	6981399	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr12:6981399C>T	ENST00000519357.1	-	2	853	c.667G>A	c.(667-669)Gag>Aag	p.E223K	SPSB2_ENST00000524270.1_Intron|SPSB2_ENST00000523102.1_Intron			Q99619	SPSB2_HUMAN	splA/ryanodine receptor domain and SOCS box containing 2	223	SOCS box.				intracellular signal transduction	cytoplasm	protein binding			kidney(2)|lung(2)|upper_aerodigestive_tract(1)	5						CCCCAGGCCTCACCTCTCCTT	0.607000											OREG0021639	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	76	218					0	0	1	0	0
RALGAPB	57148	broad.mit.edu	37	20	37117126	37117126	+	Silent	SNP	C	C	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr20:37117126C>T	ENST00000262879.6	+	2	335	c.51C>T	c.(49-51)ggC>ggT	p.G17G	RALGAPB_ENST00000397038.1_5'UTR|RALGAPB_ENST00000537204.1_Silent_p.G17G|RALGAPB_ENST00000397040.1_Silent_p.G17G|RALGAPB_ENST00000397042.3_Silent_p.G17G			Q86X10	RLGPB_HUMAN	Ral GTPase activating protein, beta subunit (non-catalytic)	17					activation of Ral GTPase activity	intracellular	protein heterodimerization activity|Ral GTPase activator activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(29)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	65						ATGATCAAGGCCATACCAGTG	0.493000													31	154					0	0	1	0	0
ESCO1	114799	broad.mit.edu	37	18	19154691	19154691	+	Silent	SNP	T	T	C			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr18:19154691T>C	ENST00000269214.5	-	4	1051	c.114A>G	c.(112-114)aaA>aaG	p.K38K		NM_052911.2	NP_443143.2	Q5FWF5	ESCO1_HUMAN	establishment of sister chromatid cohesion N-acetyltransferase 1	38					cell cycle|post-translational protein acetylation|regulation of DNA replication	chromatin|nucleus	acyltransferase activity|metal ion binding			breast(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(10)|prostate(3)|upper_aerodigestive_tract(1)	35						TTGGACCTGATTTTTTTGCTA	0.338000													36	29					0	0	1	0	0
FZD9	8326	broad.mit.edu	37	7	72850005	72850005	+	Silent	SNP	C	C	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr7:72850005C>T	ENST00000344575.3	+	1	1897	c.1668C>T	c.(1666-1668)cgC>cgT	p.R556R		NM_003508.2	NP_003499.1	O00144	FZD9_HUMAN	frizzled family receptor 9	556					B cell differentiation|brain development|canonical Wnt receptor signaling pathway|embryo development|gonad development|neuroblast proliferation|vasculature development	cell surface|filopodium membrane|integral to membrane|perinuclear region of cytoplasm	G-protein coupled receptor activity|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(4)|prostate(2)|skin(1)	14		Lung NSC(55;0.0659)|all_lung(88;0.152)				AGGCCTGCCGCGCCCCCGGGA	0.652000													7	51					0	0	1	0	0
LYST	1130	broad.mit.edu	37	1	235922848	235922848	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr1:235922848C>T	ENST00000389794.3	-	23	6479	c.6305G>A	c.(6304-6306)cGt>cAt	p.R2102H	LYST_ENST00000536965.1_3'UTR|LYST_ENST00000389793.2_Missense_Mutation_p.R2102H			Q99698	LYST_HUMAN	lysosomal trafficking regulator	2102					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(27)|lung(66)|ovary(7)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	162	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			GCTTCTAGAACGCAGCATATG	0.378000													14	66					0	0	1	0	0
ATP10A	57194	broad.mit.edu	37	15	25947187	25947187	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr15:25947187C>T	ENST00000356865.6	-	13	2747	c.2636G>A	c.(2635-2637)cGt>cAt	p.R879H		NM_024490.3	NP_077816.1	O60312	AT10A_HUMAN	ATPase, class V, type 10A	879					ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|breast(2)|endometrium(8)|kidney(2)|large_intestine(33)|liver(1)|lung(41)|ovary(3)|pancreas(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	103		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		GCCCGCTTGACGCAATTTAGA	0.527000													22	76					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	125082841	125082841	+	Splice_Site	SNP	C	C	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr8:125082841C>T	ENST00000522917.1	+	30	4172		c.e30+2		FER1L6-AS2_ENST00000520031.1_RNA|FER1L6_ENST00000399018.1_Splice_Site	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)							integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			AAATTTAAGGCAGGTTCCATT	0.418000													33	109					0	0	1	0	0
DPP8	54878	broad.mit.edu	37	15	65756226	65756226	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr15:65756226G>A	ENST00000341861.5	-	15	3472	c.1892C>T	c.(1891-1893)aCt>aTt	p.T631I	DPP8_ENST00000300141.6_Missense_Mutation_p.T615I|DPP8_ENST00000339244.5_Missense_Mutation_p.T458I|DPP8_ENST00000358939.4_Missense_Mutation_p.T615I|DPP8_ENST00000321118.7_Missense_Mutation_p.T631I|DPP8_ENST00000559233.1_Missense_Mutation_p.T631I|DPP8_ENST00000321147.6_Missense_Mutation_p.T631I	NM_197960.2	NP_932064.1	Q6V1X1	DPP8_HUMAN	dipeptidyl-peptidase 8	631					immune response|proteolysis	cytoplasm|membrane|nucleus	aminopeptidase activity|dipeptidyl-peptidase activity|serine-type peptidase activity			NS(1)|breast(2)|endometrium(3)|large_intestine(11)|lung(11)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						TTCTGGAGGAGTATAGTCAGG	0.378000													17	26					0	0	1	0	0
MEGF10	84466	broad.mit.edu	37	5	126781188	126781188	+	Missense_Mutation	SNP	G	G	T	rs138372925		TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr5:126781188G>T	ENST00000274473.6	+	21	2798	c.2531G>T	c.(2530-2532)cGa>cTa	p.R844L	MEGF10_ENST00000503335.2_Missense_Mutation_p.R844L|MEGF10_ENST00000510828.1_Intron	NM_032446.2	NP_115822.1	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10	844	Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(28)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	68		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		AGCTTAAGCCGAACCAGTACT	0.438000													39	45					1.51926e-22	1.67918e-22	1	1	0
SERAC1	84947	broad.mit.edu	37	6	158564168	158564168	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr6:158564168G>A	ENST00000367102.2	-	8	799	c.658C>T	c.(658-660)Caa>Taa	p.Q220*	SERAC1_ENST00000367104.3_Nonsense_Mutation_p.Q220*|SERAC1_ENST00000367101.1_Nonsense_Mutation_p.Q220*			Q96JX3	SRAC1_HUMAN	serine active site containing 1	220					GPI anchor metabolic process|intracellular protein transport	integral to membrane|intrinsic to endoplasmic reticulum membrane	binding|hydrolase activity, acting on ester bonds			endometrium(1)|kidney(2)|large_intestine(6)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	15		Breast(66;0.00519)|Ovarian(120;0.123)|Prostate(117;0.178)		OV - Ovarian serous cystadenocarcinoma(65;1.37e-18)|BRCA - Breast invasive adenocarcinoma(81;3.19e-05)		AGCTCTGTTTGAGGTAAGGAA	0.388000													27	52					0	0	1	0	0
SCAF4	57466	broad.mit.edu	37	21	33065763	33065763	+	Missense_Mutation	SNP	T	T	C			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr21:33065763T>C	ENST00000286835.7	-	12	1739	c.1357A>G	c.(1357-1359)Aga>Gga	p.R453G	SCAF4_ENST00000434667.3_Missense_Mutation_p.R438G|SCAF4_ENST00000399804.1_Missense_Mutation_p.R453G	NM_020706.2	NP_065757.1	O95104	SFR15_HUMAN	SR-related CTD-associated factor 4	453						nucleus	nucleotide binding|RNA binding			NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(11)|lung(15)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	54						CTTCGAGATCTAGAACCAGAT	0.453000													25	11					0	0	1	0	0
DPYD	1806	broad.mit.edu	37	1	98187182	98187182	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr1:98187182C>A	ENST00000370192.3	-	5	467	c.367G>T	c.(367-369)Ggt>Tgt	p.G123C	DPYD_ENST00000306031.5_Missense_Mutation_p.G123C|DPYD_ENST00000423006.2_Missense_Mutation_p.G86C|DPYD_ENST00000474241.1_5'UTR	NM_000110.3	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase	123					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(18)|lung(30)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	83		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	CAAGTCAGACCAAGTGGGTTG	0.348000													32	51					4.34086e-07	4.58657e-07	1	1	0
TIGD3	220359	broad.mit.edu	37	11	65123927	65123927	+	Silent	SNP	C	C	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr11:65123927C>T	ENST00000309880.5	+	2	855	c.648C>T	c.(646-648)ctC>ctT	p.L216L		NM_145719.2	NP_663771.1	Q6B0B8	TIGD3_HUMAN	tigger transposable element derived 3	216	DDE.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding			endometrium(3)|large_intestine(1)|lung(9)|prostate(2)|skin(2)	17						TGGGTGGGCTCCAGGCTGCCC	0.637000													8	129					0	0	1	0	0
DEFB126	81623	broad.mit.edu	37	20	126332	126332	+	Silent	SNP	G	G	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr20:126332G>A	ENST00000382398.3	+	2	595	c.335G>A	c.(334-336)tGa>tAa	p.*112*	DEFB126_ENST00000542572.1_3'UTR	NM_030931.3	NP_112193.1	Q9BYW3	DB126_HUMAN	defensin, beta 126	0					defense response to bacterium	extracellular region				central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(1)	4		all_cancers(10;7.65e-05)|Lung NSC(37;0.0417)|all_epithelial(17;0.0676)|all_lung(30;0.0713)|Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.122)			CCCACTGGTTGAACATTCCAG	0.473000													33	178					0	0	1	0	0
NUP210	23225	broad.mit.edu	37	3	13377074	13377074	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr3:13377074C>T	ENST00000254508.5	-	28	3805	c.3723G>A	c.(3721-3723)atG>atA	p.M1241I		NM_024923.2	NP_079199.2	Q8TEM1	PO210_HUMAN	nucleoporin 210kDa	1241					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|liver(1)|lung(16)|ovary(7)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	66	all_neural(104;0.187)					CGAGCACGTTCATGGCAAAGT	0.602000													9	99					0	0	1	0	0
MUC21	394263	broad.mit.edu	37	6	30954151	30954151	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr6:30954151G>A	ENST00000376296.3	+	2	440	c.199G>A	c.(199-201)Gtg>Atg	p.V67M	MUC21_ENST00000486149.2_5'UTR	NM_001010909.2	NP_001010909.2	Q5SSG8	MUC21_HUMAN	mucin 21, cell surface associated	67	28 X 15 AA approximate tandem repeats.|Ser-rich.					integral to membrane|plasma membrane				NS(4)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	42						AGGGTCCAGCGTGACCTCCAA	0.572000													68	180					0	0	1	0	0
PTPRG	5793	broad.mit.edu	37	3	61989042	61989042	+	Silent	SNP	C	C	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr3:61989042C>T	ENST00000474889.1	+	4	767	c.390C>T	c.(388-390)gaC>gaT	p.D130D	PTPRG_ENST00000295874.10_Silent_p.D130D	NM_002841.3	NP_002832.3	P23470	PTPRG_HUMAN	protein tyrosine phosphatase, receptor type, G	130	Alpha-carbonic anhydrase.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	identical protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(12)|liver(2)|lung(15)|ovary(7)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	62				BRCA - Breast invasive adenocarcinoma(55;0.000376)|KIRC - Kidney renal clear cell carcinoma(10;0.0499)|Kidney(10;0.065)		TTCTGAAAGACGACTATTTTG	0.438000													22	72					0	0	1	0	0
NUP210	23225	broad.mit.edu	37	3	13376980	13376980	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr3:13376980C>T	ENST00000254508.5	-	28	3899	c.3817G>A	c.(3817-3819)Gaa>Aaa	p.E1273K		NM_024923.2	NP_079199.2	Q8TEM1	PO210_HUMAN	nucleoporin 210kDa	1273					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|liver(1)|lung(16)|ovary(7)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	66	all_neural(104;0.187)					TCCGAGAGTTCTCTGGCCAGG	0.632000													15	164					0	0	1	0	0
SLC9A3	6550	broad.mit.edu	37	5	482184	482184	+	Splice_Site	SNP	C	C	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr5:482184C>T	ENST00000264938.3	-	8	1454	c.1445G>A	c.(1444-1446)cGc>cAc	p.R482H	SLC9A3_ENST00000514375.1_Splice_Site_p.R473H	NM_004174.2	NP_004165.2	P48764	SL9A3_HUMAN	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3	482						cell surface|integral to membrane	sodium:hydrogen antiporter activity			NS(2)|biliary_tract(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|liver(2)|lung(16)|prostate(3)|skin(2)|urinary_tract(1)	37			Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			CGCACTTACGCGCCCGTGCAG	0.692000													3	25					0	0	1	0	0
ELF3	1999	broad.mit.edu	37	1	201983142	201983142	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr1:201983142C>T	ENST00000359651.3	+	7	4183	c.991C>T	c.(991-993)Cgg>Tgg	p.R331W	ELF3_ENST00000367284.5_Missense_Mutation_p.R331W|RP11-510N19.5_ENST00000504773.1_RNA|ELF3_ENST00000367283.3_Missense_Mutation_p.R331W			P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription factor, epithelial-specific )	331					epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(2)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	20						GAAGCTGAGCCGGGCCATGAG	0.607000													13	9					0	0	1	0	0
CLMN	79789	broad.mit.edu	37	14	95688091	95688091	+	Silent	SNP	C	C	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr14:95688091C>T	ENST00000298912.4	-	4	374	c.261G>A	c.(259-261)tcG>tcA	p.S87S		NM_024734.3	NP_079010.2	Q96JQ2	CLMN_HUMAN	calmin (calponin-like, transmembrane)	87	Actin-binding.|CH 1.					integral to membrane	actin binding			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(17)|prostate(3)|skin(3)	44				Epithelial(152;0.193)		TACGATGCGACGAGGATTTGT	0.443000													8	43					0	0	1	0	0
CPVL	54504	broad.mit.edu	37	7	29132262	29132262	+	Silent	SNP	G	G	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr7:29132262G>A	ENST00000409850.1	-	10	1165	c.519C>T	c.(517-519)gaC>gaT	p.D173D	CPVL_ENST00000396276.3_Silent_p.D173D|CPVL_ENST00000265394.5_Silent_p.D173D			Q9H3G5	CPVL_HUMAN	carboxypeptidase, vitellogenic-like	173					proteolysis		protein binding|serine-type carboxypeptidase activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|ovary(2)|prostate(1)|skin(1)	28						GTGCTACATCGTCCTCATTGA	0.408000													4	29					0	0	1	0	0
MN1	4330	broad.mit.edu	37	22	28193514	28193514	+	Silent	SNP	C	C	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr22:28193514C>T	ENST00000302326.4	-	1	3972	c.3018G>A	c.(3016-3018)acG>acA	p.T1006T		NM_002430.2	NP_002421.3	Q10571	MN1_HUMAN	meningioma (disrupted in balanced translocation) 1	1006							binding			NS(1)|breast(2)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(6)|lung(15)|ovary(3)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	45						AGGATGGCGACGTGAGCGCCT	0.701000			T	ETV6	"""AML, meningioma"""								24	64					0	0	1	0	0
DDX24	57062	broad.mit.edu	37	14	94527268	94527268	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr14:94527268C>T	ENST00000330836.5	-	4	1519	c.1388G>A	c.(1387-1389)cGg>cAg	p.R463Q	DDX24_ENST00000544005.1_Missense_Mutation_p.R213Q|DDX24_ENST00000555054.1_Missense_Mutation_p.R420Q	NM_020414.3	NP_065147.1	Q9GZR7	DDX24_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 24	463	Helicase ATP-binding.				RNA metabolic process	cytoplasm|nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			cervix(3)|endometrium(4)|kidney(4)|large_intestine(5)|lung(3)|ovary(2)|skin(1)|urinary_tract(1)	23		all_cancers(154;0.12)		Epithelial(152;0.114)|all cancers(159;0.19)|COAD - Colon adenocarcinoma(157;0.207)		CCTGAGCTGCCGAAGGTTCCT	0.488000													7	34					0	0	1	0	0
FUT10	84750	broad.mit.edu	37	8	33247281	33247281	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr8:33247281G>A	ENST00000327671.5	-	4	1043	c.412C>T	c.(412-414)Cgg>Tgg	p.R138W	FUT10_ENST00000335589.3_Missense_Mutation_p.R76W|FUT10_ENST00000518672.1_Missense_Mutation_p.R110W|FUT10_ENST00000524021.1_Missense_Mutation_p.R110W|FUT10_ENST00000518076.1_5'UTR	NM_032664.3	NP_116053.3	Q6P4F1	FUT10_HUMAN	fucosyltransferase 10 (alpha (1,3) fucosyltransferase)	138					embryo development|fertilization|hemopoiesis|L-fucose catabolic process|nervous system development|protein folding|protein glycosylation|protein targeting|wound healing	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			cervix(1)|endometrium(1)|large_intestine(7)|liver(1)|lung(9)|ovary(1)|pancreas(1)|prostate(3)|stomach(3)|upper_aerodigestive_tract(2)	29				KIRC - Kidney renal clear cell carcinoma(67;0.129)|Kidney(114;0.154)		TGGGCTTTCCGAGGCAGAGGT	0.388000													37	71					0	0	1	0	0
SSH3	54961	broad.mit.edu	37	11	67077777	67077777	+	Silent	SNP	G	G	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr11:67077777G>A	ENST00000308127.4	+	13	1828	c.1650G>A	c.(1648-1650)ctG>ctA	p.L550L	SSH3_ENST00000376757.5_3'UTR|SSH3_ENST00000308298.7_Silent_p.L285L	NM_017857.3	NP_060327.3	Q8TE77	SSH3_HUMAN	slingshot protein phosphatase 3	550					regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton|nucleus	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(2)|cervix(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	19			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			CCTTGGAGCTGGAGAGCACCT	0.622000													12	72					0	0	1	0	0
SRRM2	23524	broad.mit.edu	37	16	2818182	2818182	+	Silent	SNP	G	G	C	rs149616150	byFrequency	TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr16:2818182G>C	ENST00000301740.8	+	11	8202	c.7653G>C	c.(7651-7653)tcG>tcC	p.S2551S	SRRM2_ENST00000574593.1_3'UTR	NM_016333.3	NP_057417.3	Q9UQ35	SRRM2_HUMAN	serine/arginine repetitive matrix 2	2551	Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|lung(34)|ovary(6)|pancreas(3)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(7)	105						cgtcgtcgtcgtcctcctcct	0.577000													11	10					0	0	1	0	0
ESCO1	114799	broad.mit.edu	37	18	19112474	19112474	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr18:19112474G>A	ENST00000269214.5	-	11	3272	c.2335C>T	c.(2335-2337)Cgt>Tgt	p.R779C		NM_052911.2	NP_443143.2	Q5FWF5	ESCO1_HUMAN	establishment of sister chromatid cohesion N-acetyltransferase 1	779					cell cycle|post-translational protein acetylation|regulation of DNA replication	chromatin|nucleus	acyltransferase activity|metal ion binding			breast(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(10)|prostate(3)|upper_aerodigestive_tract(1)	35						TTCTTCCGACGCATCATGCTG	0.408000													9	103					0	0	1	0	0
SLC7A7	9056	broad.mit.edu	37	14	23249162	23249162	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr14:23249162C>T	ENST00000397532.3	-	3	1123	c.598G>A	c.(598-600)Gtt>Att	p.V200I	SLC7A7_ENST00000397529.2_Missense_Mutation_p.V200I|SLC7A7_ENST00000285850.7_Missense_Mutation_p.V200I|SLC7A7_ENST00000555702.1_Missense_Mutation_p.V200I|SLC7A7_ENST00000554517.1_5'UTR|SLC7A7_ENST00000397528.4_Missense_Mutation_p.V200I|SLC7A7_ENST00000554061.1_5'UTR			Q9UM01	YLAT1_HUMAN	solute carrier family 7 (amino acid transporter light chain, y+L system), member 7	200					blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	basolateral plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|skin(2)	20	all_cancers(95;8.44e-05)			GBM - Glioblastoma multiforme(265;0.00741)		ATGCCTGCAACGATGACCGCG	0.413000													18	53					0	0	1	0	0
CLCN6	1185	broad.mit.edu	37	1	11867207	11867207	+	Missense_Mutation	SNP	A	A	G			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr1:11867207A>G	ENST00000346436.6	+	2	159	c.107A>G	c.(106-108)cAg>cGg	p.Q36R	CLCN6_ENST00000376487.3_Missense_Mutation_p.Q36R|CLCN6_ENST00000376492.3_3'UTR|CLCN6_ENST00000376496.3_Missense_Mutation_p.Q36R|CLCN6_ENST00000376497.3_Missense_Mutation_p.Q36R|CLCN6_ENST00000312413.6_Missense_Mutation_p.Q36R	NM_001286.3	NP_001277	P51797	CLCN6_HUMAN	chloride channel, voltage-sensitive 6	36					cell volume homeostasis|signal transduction	endosome membrane|integral to membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(12)|prostate(2)|skin(4)	36	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.13e-06)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.000816)|KIRC - Kidney renal clear cell carcinoma(229;0.00268)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		GGAGAAACACAGGAGGAGGAG	0.473000													23	14					0	0	1	0	0
SLC6A18	348932	broad.mit.edu	37	5	1232401	1232401	+	Silent	SNP	C	C	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr5:1232401C>T	ENST00000324642.3	+	2	351	c.228C>T	c.(226-228)ctC>ctT	p.L76L	SLC6A18_ENST00000296821.4_Silent_p.L76L	NM_182632.2	NP_872438.2	Q96N87	S6A18_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 18	76					cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			endometrium(1)|kidney(2)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(4)|upper_aerodigestive_tract(1)	34	all_cancers(3;2.99e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.76e-10)		Epithelial(17;0.000356)|all cancers(22;0.00124)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			ACGTCGAGCTCGCCATCGGCC	0.667000													3	38					0	0	1	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140719540	140719540	+	Silent	SNP	C	C	T	rs149528645		TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr5:140719540C>T	ENST00000394576.2	+	1	1002	c.1002C>T	c.(1000-1002)atC>atT	p.I334I	PCDHGA1_ENST00000517417.1_Intron	NM_018915.2	NP_061738.1														breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(32)|ovary(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGAAGGTTATCGTCACGGTTC	0.428000													41	135					0	0	1	0	0
DENND4B	9909	broad.mit.edu	37	1	153915377	153915377	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr1:153915377G>A	ENST00000361217.4	-	3	965	c.547C>T	c.(547-549)Ccc>Tcc	p.P183S		NM_014856.2	NP_055671.2	O75064	DEN4B_HUMAN	DENN/MADD domain containing 4B	183	MABP.									NS(1)|breast(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	36	all_lung(78;2.89e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			AGGTTGCGGGGCAGCCGGCAG	0.632000													3	43					0	0	1	0	0
WASH2P	375260	broad.mit.edu	37	2	114356340	114356340	+	RNA	SNP	C	C	G			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr2:114356340C>G	ENST00000538033.2	+	0	2520																											CACCTTCCCCCCCAGACCCAG	0.632000													3	26					0	0	1	0	0
CACNA1G	8913	broad.mit.edu	37	17	48649340	48649340	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr17:48649340G>A	ENST00000352832.5	+	5	1060	c.688G>A	c.(688-690)Gtc>Atc	p.V230I	CACNA1G_ENST00000514181.1_Missense_Mutation_p.V230I|CACNA1G_ENST00000514079.1_Missense_Mutation_p.V230I|CACNA1G_ENST00000512389.1_Missense_Mutation_p.V230I|CACNA1G_ENST00000416767.4_Missense_Mutation_p.V230I|CACNA1G_ENST00000513964.1_Missense_Mutation_p.V230I|CACNA1G_ENST00000507609.1_Missense_Mutation_p.V230I|CACNA1G_ENST00000513689.2_Missense_Mutation_p.V230I|CACNA1G_ENST00000354983.4_Missense_Mutation_p.V230I|CACNA1G_ENST00000507336.1_Missense_Mutation_p.V230I|CACNA1G_ENST00000510115.1_Missense_Mutation_p.V230I|CACNA1G_ENST00000359106.5_Missense_Mutation_p.V230I|CACNA1G_ENST00000507896.1_Missense_Mutation_p.V230I|CACNA1G_ENST00000505165.1_Missense_Mutation_p.V230I|CACNA1G_ENST00000515765.1_Missense_Mutation_p.V230I|CACNA1G_ENST00000510366.1_Missense_Mutation_p.V230I|CACNA1G_ENST00000515411.1_Missense_Mutation_p.V230I|CACNA1G_ENST00000507510.2_Missense_Mutation_p.V230I|CACNA1G_ENST00000514717.1_Missense_Mutation_p.V230I|CACNA1G_ENST00000502264.1_Missense_Mutation_p.V230I|CACNA1G_ENST00000442258.2_Missense_Mutation_p.V230I|CACNA1G_ENST00000503485.1_Missense_Mutation_p.V230I|CACNA1G_ENST00000429973.2_Missense_Mutation_p.V230I|CACNA1G_ENST00000360761.4_Missense_Mutation_p.V230I|CACNA1G_ENST00000515165.1_Missense_Mutation_p.V230I|CACNA1G_ENST00000358244.5_Missense_Mutation_p.V230I	NM_001256334.1|NM_198376.2|NM_198379.2|NM_198387.2|NM_198388.2	NP_001243263.1|NP_938190.1|NP_938193.1|NP_938201.1|NP_938202.1	O43497	CAC1G_HUMAN	calcium channel, voltage-dependent, T type, alpha 1G subunit	230					axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(5)|cervix(1)|endometrium(13)|kidney(5)|lung(23)	47	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	CATCGTCGGCGTCCAGCTGTG	0.587000													14	32					0	0	1	0	0
PXDNL	137902	broad.mit.edu	37	8	52384861	52384861	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr8:52384861C>A	ENST00000356297.4	-	8	798	c.698G>T	c.(697-699)aGc>aTc	p.S233I	PXDNL_ENST00000543296.1_Missense_Mutation_p.S233I	NM_144651.4	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	233	LRRCT.				hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				AATTCGGGGGCTCTCTGCAAC	0.408000													17	133					8.34094e-07	8.70359e-07	1	1	0
ST6GALNAC5	81849	broad.mit.edu	37	1	77510286	77510286	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr1:77510286C>A	ENST00000477717.1	+	3	894	c.659C>A	c.(658-660)aCt>aAt	p.T220N		NM_030965.1	NP_112227.1	Q9BVH7	SIA7E_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5	220					protein glycosylation	integral to Golgi membrane	sialyltransferase activity			endometrium(2)|kidney(1)|large_intestine(6)|lung(5)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)	18						AAGCAGGAGACTGGCAAAGAC	0.527000													20	216					5.35356e-11	5.80257e-11	1	1	0
SLC12A1	6557	broad.mit.edu	37	15	48541868	48541868	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr15:48541868C>A	ENST00000396577.3	+	14	1996	c.1781C>A	c.(1780-1782)tCt>tAt	p.S594Y	SLC12A1_ENST00000558405.1_Missense_Mutation_p.S594Y|SLC12A1_ENST00000380993.3_Missense_Mutation_p.S594Y	NM_001184832.1	NP_001171761.1	Q13621	S12A1_HUMAN	solute carrier family 12 (sodium/potassium/chloride transporter), member 1	594					potassium ion transport|sodium ion transport	integral to membrane|membrane fraction	sodium:potassium:chloride symporter activity			NS(2)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(30)|ovary(1)|prostate(2)|skin(1)	59		all_lung(180;0.00219)		all cancers(107;1.76e-09)|GBM - Glioblastoma multiforme(94;1.48e-06)	Bumetanide(DB00887)|Chlormerodrin(DB00534)|Chlorthalidone(DB00310)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Metolazone(DB00524)|Potassium Chloride(DB00761)|Torasemide(DB00214)|Trichlormethiazide(DB01021)	TATGCCAAATCTCCAGGTAAG	0.388000													10	48					1.08611e-07	1.1622e-07	1	1	0
ZNF786	136051	broad.mit.edu	37	7	148768943	148768943	+	Silent	SNP	T	T	C			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr7:148768943T>C	ENST00000316286.9	-	3	935	c.663A>G	c.(661-663)ccA>ccG	p.P221P	ZNF786_ENST00000451334.3_Silent_p.P270P|ZNF786_ENST00000491431.1_Silent_p.P307P			Q8N393	ZN786_HUMAN	zinc finger protein 786	307					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)|cervix(1)|kidney(1)|large_intestine(3)|lung(10)|prostate(2)|skin(2)|soft_tissue(1)|urinary_tract(2)	26	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			TGCTGTCCACTGGGAGGGAGC	0.697000													15	22					0	0	1	0	0
HSP90AA1	3320	broad.mit.edu	37	14	102549453	102549453	+	Missense_Mutation	SNP	T	T	C			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr14:102549453T>C	ENST00000334701.7	-	10	2320	c.2039A>G	c.(2038-2040)aAa>aGa	p.K680R	HSP90AA1_ENST00000216281.8_Missense_Mutation_p.K558R|HSP90AA1_ENST00000441629.2_Missense_Mutation_p.K379R	NM_001017963.2	NP_001017963.2	P07900	HS90A_HUMAN	heat shock protein 90kDa alpha (cytosolic), class A member 1	558					axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(6)|large_intestine(3)|liver(1)|lung(10)|ovary(2)|prostate(1)	28					Rifabutin(DB00615)	ctgcttctttttctcttcttc	0.383000													9	15					0	0	1	0	0
C10orf2	56652	broad.mit.edu	37	10	102749592	102749592	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr10:102749592G>C	ENST00000370228.1	+	2	1620	c.1435G>C	c.(1435-1437)Gag>Cag	p.E479Q	C10orf2_ENST00000473656.1_3'UTR|C10orf2_ENST00000311916.2_Missense_Mutation_p.E479Q	NM_001163812.1|NM_001163814.1	NP_001157284.1|NP_001157286.1	Q96RR1	PEO1_HUMAN	chromosome 10 open reading frame 2	479	SF4 helicase.		E -> K (in PEOA3).		cell death|mitochondrial DNA replication|protein hexamerization|protein homooligomerization|transcription from mitochondrial promoter	mitochondrial nucleoid	5'-3' DNA helicase activity|ATP binding|protease binding|single-stranded DNA binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|skin(1)|stomach(1)	24		Colorectal(252;0.122)|all_hematologic(284;0.152)		Epithelial(162;7.18e-11)|all cancers(201;8.75e-09)|BRCA - Breast invasive adenocarcinoma(275;0.224)		TGACCGCTTTGAGGACCTGCC	0.532000													45	144					0	0	1	0	0
ZIC1	7545	broad.mit.edu	37	3	147127954	147127954	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr3:147127954G>A	ENST00000282928.4	+	1	784	c.55G>A	c.(55-57)Gcg>Acg	p.A19T		NM_003412.3	NP_003403.2	Q15915	ZIC1_HUMAN	Zic family member 1	19					behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(4)|cervix(1)|endometrium(2)|large_intestine(8)|lung(38)|ovary(1)|prostate(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	63						CACCTTTGGCGCGTCCCGCCA	0.741000													12	37					0	0	1	0	0
ACTRT3	84517	broad.mit.edu	37	3	169485270	169485270	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr3:169485270C>T	ENST00000330368.2	-	2	1443	c.1069G>A	c.(1069-1071)Gca>Aca	p.A357T		NM_032487.4	NP_115876.3	Q9BYD9	ARPM1_HUMAN	actin-related protein T3	357						cytoplasm|cytoskeleton											TTAAATTCTGCAGCAGTGATC	0.398000													14	195					0	0	1	0	0
MCL1	4170	broad.mit.edu	37	1	150551492	150551494	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr1:150551492_150551494delTCC	ENST00000369026.2	-	1	572_574	c.513_515delGGA	c.(511-516)gaggac>gac	p.E171del	MCL1_ENST00000307940.3_In_Frame_Del_p.E171del	NM_001197320.1|NM_021960.4	NP_001184249.1|NP_068779.1	Q07820	MCL1_HUMAN	myeloid cell leukemia sequence 1 (BCL2-related)	171	PEST-like.				anti-apoptosis|apoptosis|cell fate determination|cellular homeostasis|multicellular organismal development|response to cytokine stimulus	integral to membrane|mitochondrial outer membrane|nucleoplasm	BH3 domain binding|protein binding|protein channel activity|protein heterodimerization activity			endometrium(2)|large_intestine(1)|lung(4)|prostate(1)	8	all_cancers(9;1.69e-53)|all_epithelial(9;1.95e-43)|all_lung(15;1.09e-34)|Lung NSC(24;4.04e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			GTACAACTCGTCCTCCTCCTCCT	0.635													7	192	---	---	---	---					
TNR	7143	broad.mit.edu	37	1	175372615	175372615	+	Frame_Shift_Del	DEL	C	C	-			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr1:175372615delC	ENST00000367674.2	-	4	1345	c.637delG	c.(637-639)gtgfs	p.V213fs	TNR_ENST00000263525.2_Frame_Shift_Del_p.V213fs			Q92752	TENR_HUMAN	tenascin R		Cys-rich.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					TCCACACACACCCCCCGGCTG	0.607													7	611	---	---	---	---					
CACNA1S	779	broad.mit.edu	37	1	201029886	201029886	+	Frame_Shift_Del	DEL	T	T	-			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr1:201029886delT	ENST00000362061.3	-	26	3540	c.3314delA	c.(3313-3315)aacfs	p.N1105fs	CACNA1S_ENST00000367338.3_Frame_Shift_Del_p.N1105fs	NM_000069.2	NP_000060.2	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type, alpha 1S subunit	1105					axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(19)|lung(37)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	102					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	CTGGTATGGGTTTTTGGGAAT	0.532													7	785	---	---	---	---					
ELF3	1999	broad.mit.edu	37	1	201981520	201981521	+	Frame_Shift_Ins	INS	-	-	G			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr1:201981520_201981521insG	ENST00000359651.3	+	3	3626_3627	c.434_435insG	c.(433-438)aaggatfs	p.D146fs	ELF3_ENST00000367283.3_Frame_Shift_Ins_p.D146fs|ELF3_ENST00000367284.5_Frame_Shift_Ins_p.D146fs|ELF3_ENST00000495848.1_3'UTR|RP11-510N19.5_ENST00000504773.1_RNA			P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription factor, epithelial-specific )	146					epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(2)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	20						CTGCTGGAGAAGGATGGCATGG	0.579													25	184	---	---	---	---					
FBLN2	2199	broad.mit.edu	37	3	13612699	13612701	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr3:13612699_13612701delGAG	ENST00000404922.3	+	2	963_965	c.844_846delGAG	c.(844-846)gagdel	p.E286del	FBLN2_ENST00000535798.1_In_Frame_Del_p.E312del|FBLN2_ENST00000492059.1_In_Frame_Del_p.E286del|FBLN2_ENST00000295760.7_In_Frame_Del_p.E286del	NM_001004019.1	NP_001004019.1	P98095	FBLN2_HUMAN	fibulin 2	286	N.|Subdomain NB (Cys-free).					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(10)|ovary(3)|prostate(3)|urinary_tract(1)	24			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			ggaggaagaagaggaggaggagg	0.655													7	350	---	---	---	---					
MAP4	4134	broad.mit.edu	37	3	47913557	47913558	+	In_Frame_Ins	INS	-	-	CCG			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr3:47913557_47913558insCCG	ENST00000426837.2	-	13	5877_5878	c.5790_5791insCGG	c.(5788-5793)cgggcc>cggCGGgcc	p.1930_1931insR	MAP4_ENST00000383737.4_In_Frame_Ins_p.513_514insR|MAP4_ENST00000441748.2_5'UTR|MAP4_ENST00000360240.6_In_Frame_Ins_p.785_786insR|MAP4_ENST00000264724.11_In_Frame_Ins_p.520_521insR|MAP4_ENST00000395734.3_In_Frame_Ins_p.785_786insR|MAP4_ENST00000462206.1_5'UTR|MAP4_ENST00000420772.2_In_Frame_Ins_p.536_537insR			P27816	MAP4_HUMAN	microtubule-associated protein 4	785					negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(10)|ovary(2)|pancreas(1)|skin(2)	32				BRCA - Breast invasive adenocarcinoma(193;0.000721)|KIRC - Kidney renal clear cell carcinoma(197;0.00641)|Kidney(197;0.00736)		GATGGTGAGGCCCGCTTCTCAG	0.550													74	255	---	---	---	---					
FGFRL1	53834	broad.mit.edu	37	4	1019055	1019056	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr4:1019055_1019056delCA	ENST00000398484.2	+	8	2015_2016	c.1435_1436delCA	c.(1435-1437)cacfs	p.H479fs	FGFRL1_ENST00000510644.1_Frame_Shift_Del_p.H479fs|FGFRL1_ENST00000264748.6_Frame_Shift_Del_p.H479fs|FGFRL1_ENST00000504138.1_Frame_Shift_Del_p.H479fs			Q8N441	FGRL1_HUMAN	fibroblast growth factor receptor-like 1	479	His-rich.				regulation of cell growth	integral to membrane|plasma membrane	fibroblast growth factor receptor activity|heparin binding			endometrium(1)|lung(9)|ovary(1)|prostate(1)|skin(1)	13			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			cacagacatccacacacacaca	0.584													5	9	---	---	---	---					
RRP36	88745	broad.mit.edu	37	6	42989434	42989451	+	In_Frame_Del	DEL	CGGGGCCCGACGTCCCCG	CGGGGCCCGACGTCCCCG	-			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr6:42989434_42989451delCGGGGCCCGACGTCCCCG	ENST00000244496.5	+	1	52_69	c.42_59delCGGGGCCCGACGTCCCCG	c.(40-60)gccggggcccgacgtccccgc>gcc	p.GARRPR15del		NM_033112.2	NP_149103.1	Q96EU6	RRP36_HUMAN	ribosomal RNA processing 36 homolog (S. cerevisiae)	15					ribosomal small subunit biogenesis|rRNA processing	nucleolus				NS(1)|breast(1)|central_nervous_system(1)|large_intestine(5)|lung(1)|ovary(1)|prostate(1)	11						gggccggggccggggcccgacgtccccgcggggcccgg	0.784													3	3	---	---	---	---					
THSD7A	221981	broad.mit.edu	37	7	11871469	11871470	+	In_Frame_Ins	INS	-	-	GCAGCG			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr7:11871469_11871470insGCAGCG	ENST00000423059.4	-	1	354_355	c.103_104insCGCTGC	c.(103-105)ctc>cCGCTGCtc	p.34_35insPL		NM_015204.2	NP_056019.1	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A							integral to membrane				NS(1)|autonomic_ganglia(1)|breast(5)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(7)|lung(68)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(11)	113				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		cagcagcaggagcagcggcagc	0.772										HNSCC(18;0.044)			4	8	---	---	---	---					
SSPO	23145	broad.mit.edu	37	7	149526874	149526874	+	RNA	DEL	C	C	-			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr7:149526874delC	ENST00000378016.2	+	0	15142							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			cctcctgtgtcccccccacag	0.657													2	4	---	---	---	---					
RP11-15G16.1	0	broad.mit.edu	37	8	41292930	41292932	+	RNA	DEL	GAG	GAG	-			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr8:41292930_41292932delGAG	ENST00000521725.1	+	0	114_116																											ggagaaggaagaggaggaggagg	0.547													3	6	---	---	---	---					
EMX2OS	196047	broad.mit.edu	37	10	119301868	119301869	+	RNA	INS	-	-	G			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr10:119301868_119301869insG	ENST00000551288.1	-	0	574					NR_002791.2																						aggaggaggaagaagaggagga	0.653													2	4	---	---	---	---					
MALAT1	378938	broad.mit.edu	37	11	65271371	65271374	+	RNA	DEL	AGAC	AGAC	-	rs138668622		TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr11:65271371_65271374delAGAC	ENST00000534336.1	+	0	6139_6142					NR_002819.2																						ATAACCTCTTAGACAGGTGGGAGA	0.338													5	7	---	---	---	---					
KRT19	3880	broad.mit.edu	37	17	39681230	39681231	+	Frame_Shift_Ins	INS	-	-	AG			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr17:39681230_39681231insAG	ENST00000361566.3	-	3	584_585	c.524_525insCT	c.(523-525)ctgfs	p.L175fs		NM_002276.4	NP_002267.2			keratin 19											breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|prostate(2)	12		Breast(137;0.00038)				CGCTCATGCGCAGAGCCTGTTC	0.584													77	120	---	---	---	---					
ST6GALNAC1	55808	broad.mit.edu	37	17	74625715	74625716	+	Frame_Shift_Del	DEL	TG	TG	-	rs8081258	byFrequency	TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr17:74625715_74625716delTG	ENST00000156626.7	-	2	408_409	c.209_210delCA	c.(208-210)gcafs	p.A70fs	ST6GALNAC1_ENST00000590878.1_5'UTR	NM_018414.3	NP_060884.1	Q9NSC7	SIA7A_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1	70					protein glycosylation	integral to Golgi membrane	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(11)|prostate(1)|upper_aerodigestive_tract(1)	22						TTGTCCTCCTTGCCCTTGTGGG	0.535													70	141	---	---	---	---					
ZNF578	147660	broad.mit.edu	37	19	53014654	53014654	+	Frame_Shift_Del	DEL	G	G	-			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr19:53014654delG	ENST00000421239.2	+	6	1264	c.1020delG	c.(1018-1020)gagfs	p.E340fs	CTD-3099C6.5_ENST00000599143.1_RNA	NM_001099694.1	NP_001093164.1	Q96N58	ZN578_HUMAN	zinc finger protein 578	115					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding								GBM - Glioblastoma multiforme(134;0.00819)|OV - Ovarian serous cystadenocarcinoma(262;0.01)		ACACTGGTGAGAAACCTTACA	0.403													21	119	---	---	---	---					
KIZ-AS1	101929591	broad.mit.edu	37	20	21146788	21146789	+	RNA	INS	-	-	T	rs34056823		TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr20:21146788_21146789insT	ENST00000591761.1	-	0	5051				PLK1S1_ENST00000457464.1_RNA																							tgtattttGTATTTTTTTTTTT	0.401													2	4	---	---	---	---					
BPIFB4	149954	broad.mit.edu	37	20	31685499	31685501	+	In_Frame_Del	DEL	AGA	AGA	-			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr20:31685499_31685501delAGA	ENST00000375483.3	+	11	1475_1477	c.1475_1477delAGA	c.(1474-1479)cagaag>cag	p.K493del		NM_182519.2	NP_872325.2	P59827	LPLC4_HUMAN	BPI fold containing family B, member 4	493						cytoplasm|extracellular region	lipid binding	p.K454Q(1)									GTGATGCTGCAGAAGGACAAAGC	0.576													28	140	---	---	---	---					
AP001347.6	0	broad.mit.edu	37	21	15429545	15429545	+	RNA	DEL	A	A	-			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr21:15429545delA	ENST00000428809.1	+	0	177				AP001347.6_ENST00000432621.1_RNA|AP001347.6_ENST00000448463.1_RNA																							AGGGTCATCTAAAAACCAAGG	0.642													2	4	---	---	---	---