Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
S100A5	6276	broad.mit.edu	37	1	153509783	153509783	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr1:153509783C>T	ENST00000359215.1	-	4	549	c.322G>A	c.(322-324)Gac>Aac	p.D108N	S100A5_ENST00000368718.1_Missense_Mutation_p.D90N|S100A5_ENST00000368717.2_Missense_Mutation_p.D90N			P33763	S10A5_HUMAN	S100 calcium binding protein A5	90						nucleus	calcium ion binding|copper ion binding|protein homodimerization activity|zinc ion binding			endometrium(1)|lung(1)|stomach(1)|upper_aerodigestive_tract(1)	4	all_lung(78;5.98e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			CACTTGTTGTCCTCTAGAAAG	0.582000													31	33					0	0	1	0	0
PSMA7	5688	broad.mit.edu	37	20	60714933	60714933	+	Silent	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr20:60714933G>A	ENST00000370873.4	-	3	378	c.252C>T	c.(250-252)atC>atT	p.I84I	PSMA7_ENST00000484488.1_5'UTR|PSMA7_ENST00000370858.3_Silent_p.I84I|PSMA7_ENST00000370861.1_Silent_p.I14I	NM_002792.3	NP_002783.1	O14818	PSA7_HUMAN	proteasome (prosome, macropain) subunit, alpha type, 7	84					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex, alpha-subunit complex	identical protein binding|threonine-type endopeptidase activity			large_intestine(1)|lung(2)	3	Breast(26;3.97e-09)		BRCA - Breast invasive adenocarcinoma(19;1.28e-07)			GGGCCCTGTTGATGACTATCC	0.597000													15	21					0	0	1	0	0
SORBS1	10580	broad.mit.edu	37	10	97141472	97141472	+	Silent	SNP	G	G	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr10:97141472G>T	ENST00000371247.2	-	18	1812	c.1623C>A	c.(1621-1623)ggC>ggA	p.G541G	SORBS1_ENST00000277982.5_Silent_p.G563G|SORBS1_ENST00000353505.5_Silent_p.G426G|SORBS1_ENST00000371245.3_Silent_p.G426G|SORBS1_ENST00000371227.4_Silent_p.G495G|SORBS1_ENST00000354106.3_Silent_p.G511G|SORBS1_ENST00000474353.2_5'UTR|SORBS1_ENST00000607232.1_Silent_p.G330G|SORBS1_ENST00000393949.1_Silent_p.G511G|SORBS1_ENST00000306402.6_Silent_p.G372G|SORBS1_ENST00000371241.1_Silent_p.G331G|SORBS1_ENST00000347291.4_Silent_p.G409G|SORBS1_ENST00000361941.3_Silent_p.G541G|SORBS1_ENST00000371246.2_Silent_p.G563G|SORBS1_ENST00000371239.1_Silent_p.G340G|SORBS1_ENST00000371249.2_Silent_p.G463G			Q9BX66	SRBS1_HUMAN	sorbin and SH3 domain containing 1	541					focal adhesion assembly|glucose transport|insulin receptor signaling pathway|muscle contraction|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|stress fiber assembly	centrosome|cytosol|focal adhesion|membrane raft|nucleus|stress fiber|zonula adherens	actin binding|insulin receptor binding|SH3/SH2 adaptor activity			NS(1)|breast(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(19)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	42		Colorectal(252;0.0429)		Epithelial(162;1.7e-06)|all cancers(201;6.52e-05)		CGGAAGACTTGCCAGGCTGAT	0.403000													14	79					2.32078e-09	2.528e-09	1	1	0
ZNF502	91392	broad.mit.edu	37	3	44762896	44762896	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr3:44762896C>T	ENST00000296091.4	+	4	843	c.587C>T	c.(586-588)tCa>tTa	p.S196L	ZNF502_ENST00000436624.2_Missense_Mutation_p.S196L|ZNF502_ENST00000449836.1_Missense_Mutation_p.S196L	NM_001134440.1|NM_001282880.1|NM_033210.4	NP_001127912.1|NP_001269809.1|NP_149987.2	Q8TBZ5	ZN502_HUMAN	zinc finger protein 502	196					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(4)|large_intestine(8)|lung(4)|prostate(1)|urinary_tract(1)	19				BRCA - Breast invasive adenocarcinoma(193;0.00855)|KIRC - Kidney renal clear cell carcinoma(197;0.0471)|Kidney(197;0.0589)		AGTCGTAGTTCATTCCTTGTT	0.428000													70	159					0	0	1	0	0
LYST	1130	broad.mit.edu	37	1	235884187	235884187	+	Missense_Mutation	SNP	G	G	C			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr1:235884187G>C	ENST00000389794.3	-	40	9508	c.9334C>G	c.(9334-9336)Cac>Gac	p.H3112D	LYST_ENST00000473037.1_5'UTR|LYST_ENST00000389793.2_Missense_Mutation_p.H3112D			Q99698	LYST_HUMAN	lysosomal trafficking regulator	3112					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(27)|lung(66)|ovary(7)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	162	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			AGTATATTGTGGTATACATCA	0.338000													21	91					0	0	1	0	0
CCM2	83605	broad.mit.edu	37	7	45108111	45108111	+	Missense_Mutation	SNP	C	C	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr7:45108111C>A	ENST00000381112.3	+	5	1284	c.605C>A	c.(604-606)tCc>tAc	p.S202Y	CCM2_ENST00000544363.1_Intron|CCM2_ENST00000474617.1_Intron|CCM2_ENST00000461377.1_3'UTR|CCM2_ENST00000258781.6_Missense_Mutation_p.S181Y|CCM2_ENST00000475551.1_Missense_Mutation_p.S175Y|CCM2_ENST00000541586.1_Missense_Mutation_p.S123Y	NM_001029835.2	NP_001025006.1	Q9BSQ5	CCM2_HUMAN	cerebral cavernous malformation 2	181	PID.				endothelial tube morphogenesis|integrin-mediated signaling pathway|stress-activated MAPK cascade|vasculogenesis	cytoplasm	protein binding			NS(1)|endometrium(3)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19						AGTGCAGGCTCCCTGTCGGAG	0.592000													46	62					6.1207e-33	7.04457e-33	1	1	0
SHB	6461	broad.mit.edu	37	9	37955959	37955959	+	Missense_Mutation	SNP	G	G	C			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr9:37955959G>C	ENST00000377707.3	-	4	1712	c.1147C>G	c.(1147-1149)Cct>Gct	p.P383A	RP11-613M10.9_ENST00000540557.1_3'UTR	NM_003028.2	NP_003019.2	Q15464	SHB_HUMAN	Src homology 2 domain containing adaptor protein B	383	Mediates interaction with LAT, FAK1, JAK1 and JAK3.				angiogenesis|apoptosis|cell differentiation|signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity			central_nervous_system(2)|endometrium(4)|lung(1)|prostate(1)|skin(1)|soft_tissue(1)|stomach(1)	11		all_epithelial(88;0.122)		GBM - Glioblastoma multiforme(29;3.27e-05)|Lung(182;0.0658)		TGTTTGATAGGCTTAAAGCCC	0.597000													5	2					0	0	1	0	0
HRAS	3265	broad.mit.edu	37	11	533875	533875	+	Missense_Mutation	SNP	G	G	T	rs28933406		TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr11:533875G>T	ENST00000417302.1	-	3	368	c.181C>A	c.(181-183)Cag>Aag	p.Q61K	HRAS_ENST00000468682.2_5'UTR|HRAS_ENST00000311189.7_Missense_Mutation_p.Q61K|HRAS_ENST00000397594.1_Missense_Mutation_p.Q61K|HRAS_ENST00000397596.2_Missense_Mutation_p.Q61K|HRAS_ENST00000451590.1_Missense_Mutation_p.Q61K	NM_176795.3	NP_789765.1	P01112	RASH_HUMAN	Harvey rat sarcoma viral oncogene homolog	61			Q -> K (in follicular thyroid carcinoma samples; somatic mutation; increases transformation of cultured cell lines; dbSNP:rs28933406).|Q -> L (in melanoma; strongly reduced GTP hydrolysis in the presence of RAF1; increases transformation of cultured cell lines).		activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.Q61K(61)|p.Q61R(1)|p.Q61E(1)		adrenal_gland(1)|bone(3)|breast(7)|cervix(23)|endometrium(4)|haematopoietic_and_lymphoid_tissue(12)|kidney(1)|large_intestine(2)|liver(1)|lung(16)|oesophagus(2)|penis(2)|pituitary(10)|prostate(31)|salivary_gland(24)|skin(184)|soft_tissue(38)|stomach(14)|testis(5)|thymus(1)|thyroid(173)|upper_aerodigestive_tract(122)|urinary_tract(225)	901		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	TACTCCTCCTGGCCGGCGGTA	0.597000		6	Mis		"""infrequent sarcomas, rare other types"""	"""rhadomyosarcoma, ganglioneuroblastoma, bladder"""			Costello syndrome	HNSCC(11;0.0054)			41	42					5.20837e-25	5.95707e-25	1	1	0
MT1L	4500	broad.mit.edu	37	16	56652606	56652606	+	RNA	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr16:56652606C>T	ENST00000565768.1	+	0	287					NR_001447.2				metallothionein 1L (gene/pseudogene)																		GGGGACAGCCCTGCTCCCAGA	0.512000													16	77					0	0	1	0	0
NUB1	51667	broad.mit.edu	37	7	151042482	151042482	+	Missense_Mutation	SNP	G	G	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr7:151042482G>T	ENST00000568733.1	+	2	185	c.119G>T	c.(118-120)aGg>aTg	p.R40M	NUB1_ENST00000355851.4_Missense_Mutation_p.R16M|NUB1_ENST00000413040.2_Missense_Mutation_p.R40M|NUB1_ENST00000566856.1_Missense_Mutation_p.R16M			Q9Y5A7	NUB1_HUMAN	negative regulator of ubiquitin-like proteins 1	16					positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|response to interferon-gamma|response to tumor necrosis factor|ubiquitin-dependent protein catabolic process	nucleus	protein binding			endometrium(1)|large_intestine(7)|lung(3)	11			OV - Ovarian serous cystadenocarcinoma(82;0.00569)	UCEC - Uterine corpus endometrioid carcinoma (81;0.172)		CAGTTTTTAAGGGAAGACAGG	0.303000													9	21					2.17888e-05	2.26554e-05	1	1	0
RANBP9	10048	broad.mit.edu	37	6	13639851	13639851	+	Missense_Mutation	SNP	T	T	C			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr6:13639851T>C	ENST00000011619.3	-	9	1527	c.1469A>G	c.(1468-1470)cAt>cGt	p.H490R	RANBP9_ENST00000539980.1_Missense_Mutation_p.H261R	NM_005493.2	NP_005484.2	Q96S59	RANB9_HUMAN	RAN binding protein 9	490					axon guidance|microtubule nucleation|protein complex assembly	cytosol|microtubule associated complex|nucleus	Ran GTPase binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|skin(1)	16	Breast(50;0.00669)|Ovarian(93;0.0634)	all_hematologic(90;0.117)	Epithelial(50;0.223)			ATTCATTCCATGGCTGGGGCT	0.403000													33	45					0	0	1	0	0
MYCBP2	23077	broad.mit.edu	37	13	77750673	77750673	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr13:77750673C>T	ENST00000407578.2	-	36	5697	c.5431G>A	c.(5431-5433)Gat>Aat	p.D1811N	MYCBP2_ENST00000544440.2_Missense_Mutation_p.D1773N|MYCBP2_ENST00000357337.6_Missense_Mutation_p.D1773N|MYCBP2_ENST00000360084.5_5'UTR	NM_015057.4	NP_055872.4	O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	1773					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		TCAGCTATATCACTGGGTGAG	0.363000													6	24					0	0	1	0	0
ALLC	55821	broad.mit.edu	37	2	3750104	3750104	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr2:3750104G>A	ENST00000252505.3	+	12	1289	c.1127G>A	c.(1126-1128)cGg>cAg	p.R376Q		NM_018436.3	NP_060906.3	Q8N6M5	ALLC_HUMAN	allantoicase	395							allantoicase activity			breast(4)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(12)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	30	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.088)	all_cancers(51;0.24)		OV - Ovarian serous cystadenocarcinoma(76;0.088)|all cancers(51;0.151)|Epithelial(75;0.206)		CTGAGGCCCCGGGAGAAGCCC	0.597000										HNSCC(21;0.051)			12	27					0	0	1	0	0
ZNF37A	7587	broad.mit.edu	37	10	38407406	38407406	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr10:38407406C>T	ENST00000361085.5	+	7	1672	c.1327C>T	c.(1327-1329)Cag>Tag	p.Q443*	ZNF37A_ENST00000351773.3_Nonsense_Mutation_p.Q443*	NM_001178101.1|NM_003421.2	NP_001171572.1|NP_003412.1	P17032	ZN37A_HUMAN	zinc finger protein 37A							nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(13)|prostate(1)	28						TGAATGTATTCAGTGTGGAAA	0.388000													14	46					0	0	1	0	0
BTNL9	153579	broad.mit.edu	37	5	180486555	180486555	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr5:180486555C>T	ENST00000327705.9	+	11	1532	c.1301C>T	c.(1300-1302)gCc>gTc	p.A434V	BTNL9_ENST00000376842.3_Missense_Mutation_p.A435V	NM_152547.4	NP_689760.2	Q6UXG8	BTNL9_HUMAN	butyrophilin-like 9	434	B30.2/SPRY.					integral to membrane				breast(2)|central_nervous_system(1)|kidney(4)|large_intestine(1)|lung(10)|ovary(1)	19	all_cancers(89;2.45e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TTCGTCCTGGCCCCGCACCGC	0.741000													16	17					0	0	1	0	0
HSD17B11	51170	broad.mit.edu	37	4	88312220	88312220	+	Translation_Start_Site	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr4:88312220C>T	ENST00000358290.4	-	1	318	c.3G>A	c.(1-3)atG>atA	p.M1I	HSD17B11_ENST00000507286.1_Start_Codon_SNP_p.M1I	NM_016245.3	NP_057329.2	Q8NBQ5	DHB11_HUMAN	hydroxysteroid (17-beta) dehydrogenase 11	1					androgen catabolic process|steroid biosynthetic process	cytoplasm|extracellular region	binding|estradiol 17-beta-dehydrogenase activity			cervix(1)|endometrium(4)|kidney(2)|lung(2)|ovary(2)	11		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000339)		GAAGAAATTTCATCCCTTTTG	0.428000													13	9					0	0	1	0	0
KCNA1	3736	broad.mit.edu	37	12	5020962	5020962	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr12:5020962G>T	ENST00000382545.3	+	2	1525	c.418G>T	c.(418-420)Gag>Tag	p.E140*	KCNA1_ENST00000543874.2_Intron	NM_000217.2	NP_000208.2	Q09470	KCNA1_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	140					synaptic transmission	juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium ion transmembrane transporter activity			NS(1)|breast(3)|cervix(2)|endometrium(5)|kidney(1)|large_intestine(14)|lung(23)|ovary(3)|pancreas(2)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63					Desflurane(DB01189)|Enflurane(DB00228)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	CATCAAGGAGGAGGAGCGCCC	0.627000													18	45					7.05477e-17	7.96927e-17	1	1	0
DRC1	92749	broad.mit.edu	37	2	26624885	26624885	+	Silent	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr2:26624885C>T	ENST00000288710.2	+	1	102	c.28C>T	c.(28-30)Ctg>Ttg	p.L10L		NM_145038.2	NP_659475.2			dynein regulatory complex subunit 1 homolog (Chlamydomonas)																		CCTAGAGGCCCTGGACCCGAA	0.657000													7	19					0	0	1	0	0
DISP1	84976	broad.mit.edu	37	1	223116445	223116445	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr1:223116445C>T	ENST00000284476.6	+	2	444	c.280C>T	c.(280-282)Cat>Tat	p.H94Y	DISP1_ENST00000495684.1_Intron|DISP1_ENST00000360254.2_Missense_Mutation_p.H94Y	NM_032890.3	NP_116279.2	Q96F81	DISP1_HUMAN	dispatched homolog 1 (Drosophila)	94					diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(3)|large_intestine(20)|lung(25)|prostate(4)|skin(1)|stomach(1)|urinary_tract(5)	69				GBM - Glioblastoma multiforme(131;0.102)		TTTGACTAGCCATAGCAGTCA	0.532000													29	94					0	0	1	0	0
CHEK2	11200	broad.mit.edu	37	22	29091841	29091841	+	Silent	SNP	G	G	A	rs146546850	byFrequency	TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr22:29091841G>A	ENST00000544772.1	-	12	1889	c.453C>T	c.(451-453)tcC>tcT	p.S151S	CHEK2_ENST00000328354.6_Silent_p.S372S|CHEK2_ENST00000382580.2_Silent_p.S415S|CHEK2_ENST00000382578.1_Silent_p.S281S|CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000348295.3_Silent_p.S343S|CHEK2_ENST00000403642.1_Silent_p.S281S|CHEK2_ENST00000404276.1_Silent_p.S372S|CHEK2_ENST00000405598.1_Silent_p.S372S|CHEK2_ENST00000402731.1_Silent_p.S343S|CHEK2_ENST00000382565.1_Intron	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	372	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.S372S(8)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCAAAATCTTGGAGTGCCCAA	0.413000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					6	51					0	0	1	0	0
PCDHB1	29930	broad.mit.edu	37	5	140431567	140431567	+	Missense_Mutation	SNP	C	C	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr5:140431567C>A	ENST00000306549.3	+	1	589	c.512C>A	c.(511-513)aCc>aAc	p.T171N		NM_013340.2	NP_037472.2	Q9Y5F3	PCDB1_HUMAN		171	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|liver(1)|lung(13)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	53			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CAGAACTACACCCTGAGTGCC	0.567000													12	75					7.93312e-07	8.39168e-07	1	1	0
MYH10	4628	broad.mit.edu	37	17	8417200	8417200	+	Silent	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr17:8417200C>T	ENST00000360416.3	-	22	2655	c.2517G>A	c.(2515-2517)aaG>aaA	p.K839K	MYH10_ENST00000396239.1_Silent_p.K829K|MYH10_ENST00000269243.4_Silent_p.K808K|MYH10_ENST00000379980.4_Silent_p.K824K	NM_001256012.1	NP_001242941.1	P35580	MYH10_HUMAN	myosin, heavy chain 10, non-muscle	808					actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			breast(5)|endometrium(9)|kidney(2)|large_intestine(16)|lung(9)|ovary(3)|prostate(3)|skin(4)|stomach(1)	52						GCTGCTGCTTCTTGGCAAAGG	0.458000													22	16					0	0	1	0	0
HNRNPA2B1	3181	broad.mit.edu	37	7	26237281	26237281	+	Silent	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr7:26237281C>T	ENST00000354667.4	-	3	282	c.114G>A	c.(112-114)agG>agA	p.R38R	HNRNPA2B1_ENST00000356674.7_Silent_p.R26R	NM_031243.2	NP_112533.1	P22626	ROA2_HUMAN	heterogeneous nuclear ribonucleoprotein A2/B1	38	RRM 1.				RNA transport	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	nucleotide binding|protein binding|RNA binding|single-stranded telomeric DNA binding		HNRNPA2B1/ETV1(8)	breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	22						CGTAGTAGTTCCTCAAACTTT	0.353000			T	ETV1	prostate								15	54					0	0	1	0	0
TC2N	123036	broad.mit.edu	37	14	92278710	92278710	+	Missense_Mutation	SNP	A	A	G			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr14:92278710A>G	ENST00000435962.2	-	3	570	c.247T>C	c.(247-249)Tct>Cct	p.S83P	TC2N_ENST00000340892.5_Missense_Mutation_p.S83P|TC2N_ENST00000360594.5_Missense_Mutation_p.S83P|TC2N_ENST00000556018.1_Missense_Mutation_p.S83P	NM_001128596.1	NP_001122068	Q8N9U0	TAC2N_HUMAN	tandem C2 domains, nuclear	83						nucleus				breast(1)|endometrium(2)|large_intestine(6)|liver(1)|lung(5)|skin(1)|upper_aerodigestive_tract(2)	18				COAD - Colon adenocarcinoma(157;0.218)		TGAATGTAAGATAACTTAAAC	0.363000													14	19					0	0	1	0	0
ZNF862	643641	broad.mit.edu	37	7	149558351	149558351	+	Missense_Mutation	SNP	T	T	C			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr7:149558351T>C	ENST00000223210.4	+	7	2347	c.2102T>C	c.(2101-2103)aTg>aCg	p.M701T	RP4-751H13.7_ENST00000608963.1_RNA	NM_001099220.1	NP_001092690.1	O60290	ZN862_HUMAN	zinc finger protein 862	701					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|nucleic acid binding|protein dimerization activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)|skin(1)	34						GGCTCAGCCATGTTGAGCTGC	0.632000													3	11					0	0	1	0	0
HRAS	3265	broad.mit.edu	37	11	533276	533276	+	Splice_Site	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr11:533276C>T	ENST00000417302.1	-	5	720		c.e5+1		HRAS_ENST00000311189.7_Intron|HRAS_ENST00000397594.1_Splice_Site|HRAS_ENST00000397596.2_Intron|HRAS_ENST00000451590.1_Intron	NM_176795.3	NP_789765.1	P01112	RASH_HUMAN	Harvey rat sarcoma viral oncogene homolog						activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding			adrenal_gland(1)|bone(3)|breast(7)|cervix(23)|endometrium(4)|haematopoietic_and_lymphoid_tissue(12)|kidney(1)|large_intestine(2)|liver(1)|lung(16)|oesophagus(2)|penis(2)|pituitary(10)|prostate(31)|salivary_gland(24)|skin(184)|soft_tissue(38)|stomach(14)|testis(5)|thymus(1)|thyroid(173)|upper_aerodigestive_tract(122)|urinary_tract(225)	901		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	GGGAGACTTACAGCGCGAGGG	0.726000		6	Mis		"""infrequent sarcomas, rare other types"""	"""rhadomyosarcoma, ganglioneuroblastoma, bladder"""			Costello syndrome	HNSCC(11;0.0054)			6	1					0	0	1	0	0
LRRN1	57633	broad.mit.edu	37	3	3886952	3886952	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr3:3886952G>A	ENST00000319331.3	+	2	1388	c.627G>A	c.(625-627)atG>atA	p.M209I	SUMF1_ENST00000534863.1_Intron	NM_020873.5	NP_065924.3	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1	209						integral to membrane				NS(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)|skin(1)|urinary_tract(2)	26				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		TTCTGGATATGAACTTCAAAC	0.413000													89	158					0	0	1	0	0
FAM47B	170062	broad.mit.edu	37	X	34960988	34960988	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chrX:34960988G>A	ENST00000329357.5	+	1	76	c.40G>A	c.(40-42)Ggc>Agc	p.G14S		NM_152631.2	NP_689844.2	Q8NA70	FA47B_HUMAN	family with sequence similarity 47, member B	14										breast(3)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	71						AAGGTCCCAAGGCATGGACTC	0.622000													5	20					0	0	1	0	0
RARG	5916	broad.mit.edu	37	12	53607337	53607337	+	Missense_Mutation	SNP	G	G	C			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr12:53607337G>C	ENST00000425354.2	-	8	1448	c.961C>G	c.(961-963)Ctg>Gtg	p.L321V	RARG_ENST00000338561.5_Missense_Mutation_p.L310V|RARG_ENST00000394426.1_Missense_Mutation_p.L321V|RARG_ENST00000543726.1_Missense_Mutation_p.L299V|RARG_ENST00000327550.3_Missense_Mutation_p.L249V|RARG_ENST00000543762.1_5'UTR	NM_000966.5	NP_000957.1	P13631	RARG_HUMAN	retinoic acid receptor, gamma	321	Ligand-binding.				canonical Wnt receptor signaling pathway|embryonic eye morphogenesis|embryonic hindlimb morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|regulation of cell size|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid	integral to membrane|transcription factor complex	retinoic acid receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(6)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	TCCATCTCCAGGGGCAGGAGC	0.652000											OREG0021862	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	29					0	0	1	0	0
DPF1	8193	broad.mit.edu	37	19	38709576	38709576	+	Missense_Mutation	SNP	A	A	G			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr19:38709576A>G	ENST00000416611.1	-	4	547	c.424T>C	c.(424-426)Tgt>Cgt	p.C142R	DPF1_ENST00000355526.4_Missense_Mutation_p.C168R|DPF1_ENST00000456296.1_Missense_Mutation_p.C142R|DPF1_ENST00000412732.1_Missense_Mutation_p.C86R|DPF1_ENST00000414789.1_Missense_Mutation_p.C86R|DPF1_ENST00000420980.2_Missense_Mutation_p.C168R			Q92782	DPF1_HUMAN	D4, zinc and double PHD fingers family 1	168					induction of apoptosis|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nBAF complex	zinc ion binding			large_intestine(1)|lung(4)|ovary(1)|skin(1)	7	all_cancers(60;1.24e-06)		Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			CCCACCTGACAGTCCATAATG	0.657000													44	61					0	0	1	0	0
CELSR3	1951	broad.mit.edu	37	3	48682555	48682555	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr3:48682555G>A	ENST00000544264.1	-	26	8180	c.7900C>T	c.(7900-7902)Cgc>Tgc	p.R2634C	CELSR3_ENST00000164024.4_Missense_Mutation_p.R2629C			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	2629					homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		ACCTGCATGCGGTAGAGGTGC	0.657000													14	22					0	0	1	0	0
VAMP4	8674	broad.mit.edu	37	1	171707494	171707494	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr1:171707494C>T	ENST00000236192.7	-	2	447	c.61G>A	c.(61-63)Gaa>Aaa	p.E21K	VAMP4_ENST00000482519.1_5'UTR|VAMP4_ENST00000415773.1_Missense_Mutation_p.E21K|VAMP4_ENST00000367740.2_Missense_Mutation_p.E21K	NM_001185127.1|NM_003762.4	NP_001172056.1|NP_003753.2	O75379	VAMP4_HUMAN	vesicle-associated membrane protein 4	21					vesicle-mediated transport	endosome|Golgi membrane|integral to membrane|lysosome				large_intestine(4)	4	all_cancers(6;1.42e-10)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					CTTACCCTTTCACTTTTCACA	0.363000													6	27					0	0	1	0	0
CHEK2	11200	broad.mit.edu	37	22	29091840	29091840	+	Missense_Mutation	SNP	T	T	C	rs142470496	byFrequency	TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr22:29091840T>C	ENST00000544772.1	-	12	1890	c.454A>G	c.(454-456)Aag>Gag	p.K152E	CHEK2_ENST00000328354.6_Missense_Mutation_p.K373E|CHEK2_ENST00000382580.2_Missense_Mutation_p.K416E|CHEK2_ENST00000382578.1_Missense_Mutation_p.K282E|CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000348295.3_Missense_Mutation_p.K344E|CHEK2_ENST00000403642.1_Missense_Mutation_p.K282E|CHEK2_ENST00000404276.1_Missense_Mutation_p.K373E|CHEK2_ENST00000405598.1_Missense_Mutation_p.K373E|CHEK2_ENST00000402731.1_Missense_Mutation_p.K344E|CHEK2_ENST00000382565.1_Intron	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	373	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.K373E(9)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCCAAAATCTTGGAGTGCCCA	0.418000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					6	52					0	0	1	0	0
TSPAN16	26526	broad.mit.edu	37	19	11417292	11417292	+	Missense_Mutation	SNP	G	G	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr19:11417292G>T	ENST00000316737.1	+	5	613	c.463G>T	c.(463-465)Ggg>Tgg	p.G155W	CTC-510F12.4_ENST00000586356.1_RNA|TSPAN16_ENST00000592955.1_Missense_Mutation_p.G130W|TSPAN16_ENST00000590327.1_Missense_Mutation_p.G155W	NM_012466.2	NP_036598.1	Q9UKR8	TSN16_HUMAN	tetraspanin 16	155						integral to membrane				breast(1)|endometrium(3)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)|skin(2)|stomach(1)	12						AAAGTGCTGTGGGGTGAATAA	0.438000													25	40					9.04412e-07	9.51192e-07	1	1	0
PCDHA2	56146	broad.mit.edu	37	5	140176494	140176494	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr5:140176494G>A	ENST00000526136.1	+	1	1945	c.1945G>A	c.(1945-1947)Gtg>Atg	p.V649M	PCDHA1_ENST00000394633.3_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000378132.1_Missense_Mutation_p.V649M|PCDHA2_ENST00000520672.2_Missense_Mutation_p.V649M	NM_018905.2	NP_061728.1														NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(16)|lung(26)|ovary(4)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCGCCTACTCGTGCTGGTGAA	0.652000													15	68					0	0	1	0	0
CCDC74B	91409	broad.mit.edu	37	2	130897506	130897506	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr2:130897506G>A	ENST00000392984.3	-	6	2014	c.1271C>T	c.(1270-1272)aCg>aTg	p.T424M	CCDC74B_ENST00000409943.3_Missense_Mutation_p.T256M|CCDC74B_ENST00000310463.6_Missense_Mutation_p.T322M			Q96LY2	CC74B_HUMAN	coiled-coil domain containing 74B	322										endometrium(2)|large_intestine(1)|lung(3)	6	Colorectal(110;0.1)					GGGGAAATGCGTGGCTTCTTG	0.627000													20	42					0	0	1	0	0
REEP5	7905	broad.mit.edu	37	5	112257852	112257852	+	Silent	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr5:112257852G>A	ENST00000379638.4	-	1	384	c.36C>T	c.(34-36)ttC>ttT	p.F12F	REEP5_ENST00000504247.1_Silent_p.F12F|REEP5_ENST00000513339.1_Silent_p.F12F|REEP5_ENST00000545426.1_Silent_p.F12F	NM_005669.4	NP_005660.4	Q00765	REEP5_HUMAN	receptor accessory protein 5	12						integral to membrane	protein binding			endometrium(1)|large_intestine(2)|lung(1)|ovary(1)	5		all_cancers(142;4.41e-05)|all_epithelial(76;3.65e-07)|Colorectal(10;0.00115)|Prostate(80;0.00133)|Ovarian(225;0.0443)		Epithelial(69;1.3e-09)|OV - Ovarian serous cystadenocarcinoma(64;1.26e-08)|all cancers(49;3.56e-07)|Colorectal(14;0.00778)|COAD - Colon adenocarcinoma(37;0.013)		TCTCGTGCAGGAACCGGTCGA	0.647000													5	21					0	0	1	0	0
LTA4H	4048	broad.mit.edu	37	12	96394858	96394858	+	Missense_Mutation	SNP	T	T	C			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr12:96394858T>C	ENST00000228740.2	-	19	1886	c.1745A>G	c.(1744-1746)cAt>cGt	p.H582R	LTA4H_ENST00000413268.2_3'UTR|LTA4H_ENST00000552789.1_Missense_Mutation_p.H558R|RP11-256L6.3_ENST00000551849.1_RNA	NM_000895.2	NP_000886.1	P09960	LKHA4_HUMAN	leukotriene A4 hydrolase	582					hormone biosynthetic process|inflammatory response|leukotriene biosynthetic process|peptide catabolic process|prostanoid metabolic process|proteolysis	cytosol|nucleus	aminopeptidase activity|epoxide hydrolase activity|leukotriene-A4 hydrolase activity|metallopeptidase activity|protein binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|kidney(3)|lung(4)|skin(2)|stomach(1)	12						AGCTTGATCATGGGATTTGTC	0.468000													9	50					0	0	1	0	0
B3GNT4	79369	broad.mit.edu	37	12	122689184	122689184	+	Missense_Mutation	SNP	T	T	G			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr12:122689184T>G	ENST00000324189.4	+	2	375	c.19T>G	c.(19-21)Tcc>Gcc	p.S7A	B3GNT4_ENST00000545141.1_Intron|B3GNT4_ENST00000535274.1_5'UTR|B3GNT4_ENST00000546192.1_Intron	NM_030765.2	NP_110392.1	Q9C0J1	B3GN4_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4	7					protein glycosylation	Golgi membrane|integral to membrane	galactosyltransferase activity			NS(2)|breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	13	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000297)|Epithelial(86;0.000497)|BRCA - Breast invasive adenocarcinoma(302;0.222)		TCCCCAGCCTTCCGCAGCCCA	0.652000													7	26					0	0	1	0	0
OXCT2	64064	broad.mit.edu	37	1	40236123	40236123	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr1:40236123C>T	ENST00000327582.5	-	1	897	c.805G>A	c.(805-807)Gtg>Atg	p.V269M	BMP8B_ENST00000397360.2_Intron|BMP8B_ENST00000372827.3_Intron	NM_022120.1	NP_071403.1	Q9BYC2	SCOT2_HUMAN	3-oxoacid CoA transferase 2	269					ketone body catabolic process	microtubule-based flagellum|mitochondrion	3-oxoacid CoA-transferase activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|pancreas(1)|upper_aerodigestive_tract(1)	6	all_cancers(7;5.56e-14)|all_lung(5;3.88e-17)|all_epithelial(6;3.78e-16)|Lung NSC(20;7.03e-07)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;1.92e-17)|all cancers(16;4.03e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)		Succinic acid(DB00139)	CCCTTTATCACGCGATCTACA	0.532000											OREG0013400	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	107					0	0	1	0	0
ZNF671	79891	broad.mit.edu	37	19	58232719	58232719	+	Silent	SNP	T	T	C			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr19:58232719T>C	ENST00000317398.6	-	4	830	c.735A>G	c.(733-735)aaA>aaG	p.K245K	AC003006.7_ENST00000599221.1_Intron|AC003006.7_ENST00000594684.1_Intron|ZNF671_ENST00000335820.3_Silent_p.K147K	NM_024833.2	NP_079109.2	Q8TAW3	ZN671_HUMAN	zinc finger protein 671	245					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(1)|large_intestine(6)|liver(1)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	22		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		CTCTCCTACCTTTCCCACATG	0.527000													16	44					0	0	1	0	0
GLI2	2736	broad.mit.edu	37	2	121747297	121747297	+	Silent	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr2:121747297C>T	ENST00000452319.1	+	14	3867	c.3807C>T	c.(3805-3807)tcC>tcT	p.S1269S	GLI2_ENST00000314490.11_Intron|GLI2_ENST00000361492.4_Silent_p.S1269S			P10070	GLI2_HUMAN	GLI family zinc finger 2	1269					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|lung(24)|ovary(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(3;0.0496)	Prostate(154;0.0623)				TCCCCCAATCCTGCAGCAACA	0.622000													24	15					0	0	1	0	0
TMEM208	29100	broad.mit.edu	37	16	67262275	67262275	+	Silent	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr16:67262275G>A	ENST00000565201.1	+	3	171	c.120G>A	c.(118-120)gtG>gtA	p.V40V	TMEM208_ENST00000304800.9_Silent_p.V40V|TMEM208_ENST00000563953.1_5'UTR			Q9BTX3	TM208_HUMAN	transmembrane protein 208	40						integral to membrane				breast(1)|kidney(2)|lung(1)|upper_aerodigestive_tract(1)	5		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00067)|Epithelial(162;0.00442)|all cancers(182;0.0417)		ACTGCCTTGTGACGTTGGTCT	0.512000													20	54					0	0	1	0	0
GPR37	2861	broad.mit.edu	37	7	124386891	124386891	+	Missense_Mutation	SNP	G	G	C			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr7:124386891G>C	ENST00000303921.2	-	2	2180	c.1530C>G	c.(1528-1530)atC>atG	p.I510M		NM_005302.3	NP_005293.1	O15354	GPR37_HUMAN	G protein-coupled receptor 37 (endothelin receptor type B-like)	510						endoplasmic reticulum membrane|integral to plasma membrane	G-protein coupled receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(8)|lung(11)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						CAATGTTGCAGATATTTTCAG	0.418000													22	72					0	0	1	0	0
ARMC3	219681	broad.mit.edu	37	10	23326230	23326230	+	Missense_Mutation	SNP	C	C	G			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr10:23326230C>G	ENST00000298032.5	+	19	2525	c.2441C>G	c.(2440-2442)tCc>tGc	p.S814C	ARMC3_ENST00000376528.4_Missense_Mutation_p.S551C|ARMC3_ENST00000409983.3_Missense_Mutation_p.S807C	NM_173081.3	NP_775104.2	Q5W041	ARMC3_HUMAN	armadillo repeat containing 3	814							binding			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(24)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						ATTGGTTGCTCCCTAGTTCGC	0.532000													26	59					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144922560	144922560	+	Missense_Mutation	SNP	T	T	C			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr1:144922560T>C	ENST00000529945.1	-	3	1775	c.1336A>G	c.(1336-1338)Att>Gtt	p.I446V	PDE4DIP_ENST00000369349.3_Missense_Mutation_p.I283V|PDE4DIP_ENST00000369359.4_Missense_Mutation_p.I420V|PDE4DIP_ENST00000369356.4_Missense_Mutation_p.I283V|PDE4DIP_ENST00000313382.9_Missense_Mutation_p.I349V|PDE4DIP_ENST00000530740.1_Missense_Mutation_p.I420V|PDE4DIP_ENST00000313431.9_Missense_Mutation_p.I446V|PDE4DIP_ENST00000369354.3_Missense_Mutation_p.I283V|PDE4DIP_ENST00000369351.3_Missense_Mutation_p.I283V|PDE4DIP_ENST00000479408.2_Missense_Mutation_p.I70V			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	283					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		AGGTTCTGAATTGTACCATCT	0.388000			T	PDGFRB	MPD								48	383					0	0	1	0	0
SQSTM1	8878	broad.mit.edu	37	5	179263587	179263587	+	Missense_Mutation	SNP	G	G	A	rs11548636		TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr5:179263587G>A	ENST00000510187.1	+	7	1083	c.1067G>A	c.(1066-1068)cGt>cAt	p.R356H	SQSTM1_ENST00000389805.4_Silent_p.P439P|SQSTM1_ENST00000402874.3_Silent_p.P355P|SQSTM1_ENST00000360718.5_Silent_p.P355P|SQSTM1_ENST00000376929.3_Silent_p.P355P|C5orf45_ENST00000403396.2_3'UTR			Q13501	SQSTM_HUMAN	sequestosome 1	0	Interaction with NTRK1 (By similarity).				anti-apoptosis|apoptosis|cell differentiation|endosome transport|induction of apoptosis by extracellular signals|intracellular signal transduction|macroautophagy|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|protein localization|regulation of I-kappaB kinase/NF-kappaB cascade|ubiquitin-dependent protein catabolic process	cytosol|late endosome|nucleoplasm	protein kinase C binding|receptor tyrosine kinase binding|SH2 domain binding|ubiquitin binding|zinc ion binding		SQSTM1/ALK(2)	NS(1)|breast(1)|endometrium(1)|large_intestine(2)|liver(2)|lung(5)|ovary(1)	13	all_cancers(89;0.000205)|all_epithelial(37;7.15e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0395)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ATCCCCCGCCGTTGTGACCAC	0.542000													48	56					0	0	1	0	0
PPFIBP1	8496	broad.mit.edu	37	12	27788072	27788072	+	Missense_Mutation	SNP	C	C	G			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr12:27788072C>G	ENST00000545334.1	+	4	625	c.294C>G	c.(292-294)ttC>ttG	p.F98L	PPFIBP1_ENST00000537927.1_Intron|PPFIBP1_ENST00000318304.8_Intron|PPFIBP1_ENST00000535047.1_Intron|PPFIBP1_ENST00000542629.1_Intron|PPFIBP1_ENST00000228425.6_Intron			Q86W92	LIPB1_HUMAN	PTPRF interacting protein, binding protein 1 (liprin beta 1)	0					cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(13)|prostate(2)|skin(1)	32	Lung SC(9;0.0873)					GTTCCAAATTCTGTTATAAAT	0.383000													14	15					0	0	1	0	0
PIK3C2G	5288	broad.mit.edu	37	12	18644430	18644430	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr12:18644430G>A	ENST00000433979.1	+	19	2724	c.2608G>A	c.(2608-2610)Gat>Aat	p.D870N	PIK3C2G_ENST00000538779.1_Missense_Mutation_p.D911N|PIK3C2G_ENST00000266497.5_Missense_Mutation_p.D870N	NM_004570.4	NP_004561.3	O75747	P3C2G_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma	870					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			breast(5)|central_nervous_system(6)|endometrium(2)|kidney(4)|large_intestine(8)|lung(31)|ovary(2)|prostate(1)|skin(2)|stomach(4)|upper_aerodigestive_tract(1)	66		Hepatocellular(102;0.194)				GTTCTTTCAAGATGTAAATAC	0.333000													12	59					0	0	1	0	0
YJEFN3	374887	broad.mit.edu	37	19	19646428	19646428	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr19:19646428C>T	ENST00000555938.1	+	7	643	c.631C>T	c.(631-633)Cgc>Tgc	p.R211C	YJEFN3_ENST00000608404.1_Missense_Mutation_p.R211C|YJEFN3_ENST00000514277.4_Missense_Mutation_p.R212C|YJEFN3_ENST00000436027.5_Missense_Mutation_p.R162C																							CCCCTGCACCCGCGCGCTGGC	0.706000													3	9					0	0	1	0	0
CDC42BPB	9578	broad.mit.edu	37	14	103440459	103440459	+	Missense_Mutation	SNP	T	T	G			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr14:103440459T>G	ENST00000361246.2	-	12	1823	c.1535A>C	c.(1534-1536)gAg>gCg	p.E512A		NM_006035.3	NP_006026.3	Q9Y5S2	MRCKB_HUMAN	CDC42 binding protein kinase beta (DMPK-like)	512					actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(11)|liver(1)|lung(14)|ovary(2)|prostate(2)|skin(3)|stomach(1)	49		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		CACTGTGTCCTCAAGCTGTCG	0.532000													12	36					0	0	1	0	0
TFAP2E	339488	broad.mit.edu	37	1	36055616	36055616	+	Missense_Mutation	SNP	G	G	A	rs149882646		TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr1:36055616G>A	ENST00000373235.3	+	5	1079	c.871G>A	c.(871-873)Gcc>Acc	p.A291T		NM_178548.3	NP_848643.2	Q6VUC0	AP2E_HUMAN	transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon)	291	H-S-H (helix-span-helix), dimerization.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(1)	2		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.196)				TCGCAAGGCCGCCAATGTGAC	0.577000													3	26					0	0	1	0	0
RBM44	375316	broad.mit.edu	37	2	238726589	238726589	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr2:238726589G>A	ENST00000316997.4	+	3	1162	c.1030G>A	c.(1030-1032)Gga>Aga	p.G344R	RBM44_ENST00000444524.2_Intron|RBM44_ENST00000409864.1_Missense_Mutation_p.G344R	NM_001080504.2	NP_001073973.2	Q6ZP01	RBM44_HUMAN	RNA binding motif protein 44	343							nucleotide binding|RNA binding			breast(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(7)|ovary(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	33		Breast(86;0.0042)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;3.74e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.3e-11)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000118)|Lung(119;0.0112)|LUSC - Lung squamous cell carcinoma(224;0.0266)		AGATTTTTGTGGAAATAAAAT	0.308000													28	20					0	0	1	0	0
PAK2	5062	broad.mit.edu	37	3	196530009	196530009	+	Missense_Mutation	SNP	A	A	C			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr3:196530009A>C	ENST00000327134.3	+	4	732	c.410A>C	c.(409-411)cAg>cCg	p.Q137P		NM_002577.4	NP_002568.2	Q13177	PAK2_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 2	137	Autoregulatory region (By similarity).				axon guidance|cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of protein kinase activity|peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of apoptosis|regulation of defense response to virus by virus|regulation of growth|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|nucleus|perinuclear region of cytoplasm|plasma membrane	ATP binding|identical protein binding|protein kinase binding|protein serine/threonine kinase activity|protein tyrosine kinase activator activity			breast(1)|cervix(1)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)	12	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.07e-23)|all cancers(36;6.38e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.5e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00405)		ACAGTGAAGCAGAAATATCTG	0.428000													36	19					0	0	1	0	0
BRSK2	9024	broad.mit.edu	37	11	1463777	1463777	+	Silent	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr11:1463777C>T	ENST00000308219.9	+	5	857	c.471C>T	c.(469-471)atC>atT	p.I157I	BRSK2_ENST00000526678.1_Silent_p.I157I|BRSK2_ENST00000531197.1_Silent_p.I157I|BRSK2_ENST00000528710.1_Silent_p.I97I|BRSK2_ENST00000308230.5_Silent_p.I157I|BRSK2_ENST00000382179.1_Silent_p.I203I|BRSK2_ENST00000528841.1_Silent_p.I157I|BRSK2_ENST00000544817.1_5'UTR	NM_001256627.1|NM_003957.3	NP_001243556.1|NP_003948.2	Q8IWQ3	BRSK2_HUMAN	BR serine/threonine kinase 2	157	Protein kinase.				establishment of cell polarity|neuron differentiation		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			endometrium(4)|large_intestine(1)|lung(5)	10		all_epithelial(84;4.17e-05)|Breast(177;0.000307)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00144)|Lung(200;0.0713)|LUSC - Lung squamous cell carcinoma(625;0.0842)		ACATCCGCATCGCAGACTTTG	0.622000													19	9					0	0	1	0	0
ERCC2	2068	broad.mit.edu	37	19	45872380	45872380	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr19:45872380G>A	ENST00000391945.4	-	3	208	c.131C>T	c.(130-132)tCa>tTa	p.S44L	ERCC2_ENST00000485403.2_Missense_Mutation_p.S20L|ERCC2_ENST00000221481.6_Missense_Mutation_p.S44L|ERCC2_ENST00000391940.4_Missense_Mutation_p.S20L|ERCC2_ENST00000391944.3_Missense_Mutation_p.S44L	NM_000400.3	NP_000391.1	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 2	44	Helicase ATP-binding.				cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			large_intestine(4)|lung(2)|ovary(1)|pancreas(1)|stomach(1)	9		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		CCCGGTGCCTGAGGGCATCTC	0.587000			"""Mis, N, F, S"""			"""skin basal cell, skin squamous cell, melanoma"""		Nucleotide excision repair (NER)	Xeroderma Pigmentosum				18	77					0	0	1	0	0
TSHZ3	57616	broad.mit.edu	37	19	31768141	31768141	+	Missense_Mutation	SNP	T	T	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr19:31768141T>A	ENST00000240587.4	-	2	2885	c.2558A>T	c.(2557-2559)aAc>aTc	p.N853I		NM_020856.2	NP_065907.2	Q63HK5	TSH3_HUMAN	teashirt zinc finger homeobox 3	853					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|endometrium(15)|kidney(9)|large_intestine(20)|lung(60)|ovary(4)|pancreas(2)|prostate(4)|skin(5)	123	Esophageal squamous(110;0.226)					CTCTGTCAAGTTCTTCAGCAT	0.527000													22	91					0	0	1	0	0
ZNF37A	7587	broad.mit.edu	37	10	38407014	38407014	+	Nonsense_Mutation	SNP	C	C	G			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr10:38407014C>G	ENST00000361085.5	+	7	1280	c.935C>G	c.(934-936)tCa>tGa	p.S312*	ZNF37A_ENST00000351773.3_Nonsense_Mutation_p.S312*	NM_001178101.1|NM_003421.2	NP_001171572.1|NP_003412.1	P17032	ZN37A_HUMAN	zinc finger protein 37A							nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(13)|prostate(1)	28						TATAAGAATTCAGACCTCATT	0.423000													36	76					0	0	1	0	0
SGK223	157285	broad.mit.edu	37	8	8235550	8235550	+	Silent	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr8:8235550C>T	ENST00000520004.1	-	3	633	c.369G>A	c.(367-369)ccG>ccA	p.P123P	SGK223_ENST00000330777.4_Silent_p.P123P			Q86YV5	SG223_HUMAN		123							ATP binding|non-membrane spanning protein tyrosine kinase activity										CCTCCTGCTTCGGGAGGGGGA	0.552000													36	19					0	0	1	0	0
CCDC40	55036	broad.mit.edu	37	17	78013909	78013909	+	Missense_Mutation	SNP	G	G	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr17:78013909G>T	ENST00000397545.4	+	3	419	c.392G>T	c.(391-393)aGt>aTt	p.S131I	CCDC40_ENST00000374876.4_Missense_Mutation_p.S131I|CCDC40_ENST00000374877.3_Missense_Mutation_p.S131I|CCDC40_ENST00000269318.5_Missense_Mutation_p.S131I	NM_017950.3	NP_060420.2	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	131					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(7)|lung(12)|ovary(4)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	38	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			GCATACGATAGTGTTAGCGGG	0.567000													4	45					1.024e-07	1.08949e-07	1	1	0
PCDHGA12	26025	broad.mit.edu	37	5	140811312	140811312	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr5:140811312C>T	ENST00000252085.3	+	1	1128	c.986C>T	c.(985-987)gCg>gTg	p.A329V	PCDHGA10_ENST00000398610.2_Intron|PCDHGA11_ENST00000518882.1_Intron|PCDHGB7_ENST00000398594.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA11_ENST00000398587.2_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron	NM_003735.2|NM_032094.1	NP_003726.1|NP_115265.1														breast(2)|cervix(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(23)|ovary(5)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	58			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGATATTCTGCGCGAGCCAAA	0.507000													50	71					0	0	1	0	0
MIPEP	4285	broad.mit.edu	37	13	24304530	24304530	+	Missense_Mutation	SNP	T	T	C			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr13:24304530T>C	ENST00000382172.3	-	19	2197	c.2099A>G	c.(2098-2100)gAc>gGc	p.D700G		NM_005932.3	NP_005923	Q99797	MIPEP_HUMAN	mitochondrial intermediate peptidase	700					protein processing involved in protein targeting to mitochondrion|proteolysis	mitochondrial matrix	metal ion binding|metalloendopeptidase activity			breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|liver(1)|lung(12)|prostate(2)|skin(1)	27		all_cancers(29;1.83e-22)|all_epithelial(30;8.75e-19)|all_lung(29;9.17e-18)|Lung SC(185;0.0225)|Breast(139;0.14)		all cancers(112;0.00389)|Epithelial(112;0.0266)|OV - Ovarian serous cystadenocarcinoma(117;0.0717)|Lung(94;0.207)|GBM - Glioblastoma multiforme(144;0.232)		CAGATCCAAGTCGGAAACGAG	0.413000													21	11					0	0	1	0	0
ANKRD36B	57730	broad.mit.edu	37	2	98206189	98206189	+	RNA	SNP	G	G	T	rs117911431	by1000genomes	TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr2:98206189G>T	ENST00000443455.1	-	0	138							Q8N2N9	AN36B_HUMAN	ankyrin repeat domain 36B																		TTCCTTAATCGTCGGCTGCAA	0.562000													4	23					1	1	1	1	0
GPR98	84059	broad.mit.edu	37	5	89990019	89990019	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr5:89990019C>A	ENST00000405460.2	+	33	7542	c.7446C>A	c.(7444-7446)taC>taA	p.Y2482*		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	2482					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TCTGGACCTACAGGAAAAACA	0.493000													8	47					0.000157383	0.0001609	1	1	0
NEFM	4741	broad.mit.edu	37	8	24771306	24771306	+	Translation_Start_Site	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr8:24771306G>A	ENST00000221166.5	+	0	782				GS1-72M22.1_ENST00000607058.1_RNA|NEFM_ENST00000521540.1_3'UTR|NEFM_ENST00000518131.1_De_novo_Start_InFrame|NEFM_ENST00000437366.2_De_novo_Start_InFrame			P07197	NFM_HUMAN	neurofilament, medium polypeptide							neurofilament	protein binding|structural constituent of cytoskeleton	p.?(1)		breast(3)|endometrium(7)|kidney(4)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|urinary_tract(1)	36		Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		AGGCCTCCAAGATGAGCTACA	0.706000													4	4					0	0	1	0	0
DIDO1	11083	broad.mit.edu	37	20	61527666	61527666	+	Missense_Mutation	SNP	A	A	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr20:61527666A>T	ENST00000266070.4	-	8	2458	c.2133T>A	c.(2131-2133)ttT>ttA	p.F711L	DIDO1_ENST00000395340.1_Missense_Mutation_p.F711L|DIDO1_ENST00000395343.1_Missense_Mutation_p.F711L|DIDO1_ENST00000395335.2_Missense_Mutation_p.F711L	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	711	TFIIS central.				apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					GAAACAAGTTAAACATCTCCT	0.388000													23	56					0	0	1	0	0
AHCTF1	25909	broad.mit.edu	37	1	247025300	247025300	+	Silent	SNP	T	T	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr1:247025300T>A	ENST00000366508.1	-	28	3937	c.3801A>T	c.(3799-3801)tcA>tcT	p.S1267S	AHCTF1_ENST00000470300.1_5'UTR|AHCTF1_ENST00000326225.3_Silent_p.S1241S|AHCTF1_ENST00000391829.2_Silent_p.S1232S			Q8WYP5	ELYS_HUMAN	AT hook containing transcription factor 1	1232	Necessary for nuclear localization (By similarity).				cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			NS(1)|breast(6)|cervix(3)|endometrium(8)|kidney(6)|large_intestine(12)|liver(2)|lung(21)|ovary(5)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	74	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			CTTCCACAAATGAAATTCTAG	0.398000													21	21					0	0	1	0	0
DCLK3	85443	broad.mit.edu	37	3	36779198	36779198	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr3:36779198G>A	ENST00000416516.2	-	2	1443	c.953C>T	c.(952-954)cCt>cTt	p.P318L		NM_033403.1	NP_208382.1	Q9C098	DCLK3_HUMAN	doublecortin-like kinase 3	318						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			breast(3)|endometrium(3)|kidney(2)|large_intestine(11)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	48						TAGCTTTGCAGGTTGGTCATC	0.567000													53	131					0	0	1	0	0
LMLN	89782	broad.mit.edu	37	3	197712742	197712742	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr3:197712742C>T	ENST00000330198.4	+	8	932	c.910C>T	c.(910-912)Ctc>Ttc	p.L304F	LMLN_ENST00000482695.1_Missense_Mutation_p.L252F|LMLN_ENST00000420910.2_Missense_Mutation_p.L304F|LMLN_ENST00000332636.5_Missense_Mutation_p.L252F	NM_033029.3	NP_149018.2	Q96KR4	LMLN_HUMAN	leishmanolysin-like (metallopeptidase M8 family)	304					cell adhesion|cell division|mitosis|proteolysis	cytoplasm|membrane	metalloendopeptidase activity|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)	Lung NSC(153;0.132)	Epithelial(36;9.84e-24)|all cancers(36;3.18e-22)|OV - Ovarian serous cystadenocarcinoma(49;5.35e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.111)		TGCAGATGGCCTCCCACCTTT	0.378000													17	10					0	0	1	0	0
ACOX3	8310	broad.mit.edu	37	4	8412072	8412072	+	Missense_Mutation	SNP	A	A	G			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr4:8412072A>G	ENST00000356406.5	-	6	631	c.554T>C	c.(553-555)aTa>aCa	p.I185T	ACOX3_ENST00000503233.1_Missense_Mutation_p.I185T|ACOX3_ENST00000413009.2_Missense_Mutation_p.I185T	NM_003501.2	NP_003492.2	O15254	ACOX3_HUMAN	acyl-CoA oxidase 3, pristanoyl	185					bile acid metabolic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|pristanoyl-CoA oxidase activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(9)|lung(17)|prostate(1)|skin(3)|stomach(1)	42						AGGGGAATGTATGATGAATTC	0.438000													27	16					0	0	1	0	0
ENO3	2027	broad.mit.edu	37	17	4859385	4859385	+	Missense_Mutation	SNP	C	C	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr17:4859385C>A	ENST00000323997.6	+	9	1146	c.1014C>A	c.(1012-1014)aaC>aaA	p.N338K	ENO3_ENST00000518175.1_Missense_Mutation_p.N338K|ENO3_ENST00000519584.1_Missense_Mutation_p.N295K	NM_001976.4|NM_053013.3	NP_001967.3|NP_443739.3	P13929	ENOB_HUMAN	enolase 3 (beta, muscle)	338					gluconeogenesis|glycolysis	phosphopyruvate hydratase complex	magnesium ion binding|phosphopyruvate hydratase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(8)|ovary(1)	15						AGGCCTGCAACTGTCTGCTGC	0.597000													21	54					2.4624e-09	2.66638e-09	1	1	0
DDX5	1655	broad.mit.edu	37	17	62496243	62496243	+	Missense_Mutation	SNP	T	T	C			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr17:62496243T>C	ENST00000225792.5	-	13	2044	c.1643A>G	c.(1642-1644)aAt>aGt	p.N548S	DDX5_ENST00000450599.2_Missense_Mutation_p.N469S|DDX5_ENST00000580026.1_5'UTR|DDX5_ENST00000578804.1_Missense_Mutation_p.N548S	NM_004396.3	NP_004387.1	P17844	DDX5_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 5	548					cell growth|regulation of alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|mRNA binding|protein binding|RNA helicase activity|transcription cofactor activity			breast(3)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)	19	Breast(5;2.15e-14)		BRCA - Breast invasive adenocarcinoma(8;8.6e-12)			AGACACAAAATTACTTCCAAA	0.413000			T	ETV4	prostate								59	60					0	0	1	0	0
PRPF38B	55119	broad.mit.edu	37	1	109242068	109242068	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr1:109242068G>A	ENST00000370021.1	+	7	1371	c.734G>A	c.(733-735)aGa>aAa	p.R245K	PRPF38B_ENST00000370025.4_Missense_Mutation_p.R356K			Q5VTL8	PR38B_HUMAN	pre-mRNA processing factor 38B	356					mRNA processing|RNA splicing	spliceosomal complex		p.R356T(1)		NS(1)|kidney(3)|large_intestine(5)|lung(8)|prostate(1)|skin(1)	19		all_epithelial(167;0.000154)|all_lung(203;0.00026)|Lung NSC(277;0.000508)		Colorectal(144;0.0149)|Lung(183;0.0888)|COAD - Colon adenocarcinoma(174;0.113)|Epithelial(280;0.161)		gatcgagaaagagagaaagaa	0.478000													8	26					0	0	1	0	0
PC	5091	broad.mit.edu	37	11	66636412	66636412	+	Silent	SNP	G	G	C			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr11:66636412G>C	ENST00000393960.1	-	10	1208	c.927C>G	c.(925-927)acC>acG	p.T309T	PC_ENST00000355677.3_Silent_p.T309T|PC_ENST00000393958.2_Silent_p.T309T|PC_ENST00000524491.1_Silent_p.T269T|PC_ENST00000393955.2_Silent_p.T309T	NM_001040716.1	NP_001035806.1	P11498	PYC_HUMAN	pyruvate carboxylase	309	ATP-grasp.|Biotin carboxylation.				gluconeogenesis|lipid biosynthetic process	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|pyruvate carboxylase activity			cervix(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		Melanoma(852;0.0525)		Lung(977;0.153)|LUSC - Lung squamous cell carcinoma(976;0.227)	Biotin(DB00121)|Pyruvic acid(DB00119)	GGAACTCCACGGTGCCTGCGT	0.637000													17	49					0	0	1	0	0
LOC541473	541473	broad.mit.edu	37	7	75023544	75023544	+	RNA	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr7:75023544C>T	ENST00000275590.5	-	0	414				STAG3L1_ENST00000402225.5_RNA																							AATTTACCCTCTCCAAGTTTC	0.463000													6	28					0	0	1	0	0
PPRC1	23082	broad.mit.edu	37	10	103907098	103907098	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr10:103907098C>T	ENST00000278070.2	+	9	4388	c.4349C>T	c.(4348-4350)tCa>tTa	p.S1450L	PPRC1_ENST00000489648.1_Intron|PPRC1_ENST00000413464.2_Intron|PPRC1_ENST00000370012.1_Missense_Mutation_p.S417L	NM_015062.3	NP_055877.3	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator-related 1	1450	Arg-rich.|Necessary for interaction with CREB1 and NRF1.|Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(10)|lung(19)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	56		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		TCGTCTTCCTCATCCCGATCT	0.597000													34	22					0	0	1	0	0
MAGI2	9863	broad.mit.edu	37	7	78130897	78130897	+	Missense_Mutation	SNP	A	A	G			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr7:78130897A>G	ENST00000354212.4	-	5	1215	c.962T>C	c.(961-963)aTt>aCt	p.I321T	MAGI2_ENST00000419488.1_Missense_Mutation_p.I321T|MAGI2_ENST00000536571.1_Missense_Mutation_p.I153T|MAGI2_ENST00000522391.1_Missense_Mutation_p.I321T|MAGI2_ENST00000535697.1_Missense_Mutation_p.I158T	NM_012301.3	NP_036433.2	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 2	321	Interaction with DDN.|WW 1.					cell junction|synapse|synaptosome	phosphatase binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(37)|ovary(5)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(3)	84		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				AACTCACTCAATGAAGTAGAC	0.393000													17	67					0	0	1	0	0
MESDC2	23184	broad.mit.edu	37	15	81282111	81282111	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr15:81282111G>A	ENST00000261758.4	-	1	108	c.22C>T	c.(22-24)Cgc>Tgc	p.R8C		NM_015154.1	NP_055969.1	Q14696	MESD_HUMAN	mesoderm development candidate 2	8	Chaperone domain (By similarity).				mesoderm development|protein folding|Wnt receptor signaling pathway	endoplasmic reticulum				cervix(1)|large_intestine(5)|ovary(1)|urinary_tract(1)	8						ACGGCCTTGCGCGCCCACCTG	0.716000													13	3					0	0	1	0	0
SDHA	6389	broad.mit.edu	37	5	236602	236602	+	Silent	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr5:236602G>A	ENST00000264932.6	+	10	1435	c.1320G>A	c.(1318-1320)gaG>gaA	p.E440E	SDHA_ENST00000510361.1_Silent_p.E392E|SDHA_ENST00000504309.1_Silent_p.E440E	NM_004168.2	NP_004159.2	P31040	DHSA_HUMAN	succinate dehydrogenase complex, subunit A, flavoprotein (Fp)	440					nervous system development|respiratory electron transport chain|succinate metabolic process|transport|tricarboxylic acid cycle	mitochondrial respiratory chain complex II	electron carrier activity|flavin adenine dinucleotide binding|protein binding|succinate dehydrogenase (ubiquinone) activity	p.E440E(1)		NS(1)|breast(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|liver(2)|lung(16)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	40			Epithelial(17;0.0159)|all cancers(22;0.0236)|OV - Ovarian serous cystadenocarcinoma(19;0.0674)|Lung(60;0.113)		Succinic acid(DB00139)	CCTGTGGGGAGGCCGCCTGTG	0.592000									Familial Paragangliomas				20	47					0	0	1	0	0
MYH8	4626	broad.mit.edu	37	17	10298707	10298707	+	Missense_Mutation	SNP	T	T	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr17:10298707T>A	ENST00000403437.2	-	34	4799	c.4705A>T	c.(4705-4707)Aac>Tac	p.N1569Y	RP11-799N11.1_ENST00000581304.1_RNA|CTC-297N7.11_ENST00000587182.2_RNA|RP11-799N11.1_ENST00000399342.2_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	1569					muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						TTGACTTGGTTTAACTCAAGC	0.393000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				21	64					0	0	1	0	0
ATP13A3	79572	broad.mit.edu	37	3	194174455	194174455	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr3:194174455G>A	ENST00000439040.1	-	10	1609	c.818C>T	c.(817-819)tCa>tTa	p.S273L	ATP13A3_ENST00000256031.4_Missense_Mutation_p.S273L			Q9H7F0	AT133_HUMAN	ATPase type 13A3	273					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			NS(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	24	all_cancers(143;6.01e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;3.83e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;5.98e-05)		TCTACAAACTGAAACTCTTAC	0.348000													19	24					0	0	1	0	0
FAM86EP	348926	broad.mit.edu	37	4	3954855	3954855	+	RNA	SNP	G	G	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr4:3954855G>T	ENST00000281228.8	-	0	143				FAM86EP_ENST00000313946.8_RNA																							AAAATATCCCGCCGCAGCTCA	0.493000													4	62					0.0215528	0.0217909	1	1	0
MED12	9968	broad.mit.edu	37	X	70349240	70349240	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chrX:70349240G>A	ENST00000333646.6	+	26	3851	c.3652G>A	c.(3652-3654)Gga>Aga	p.G1218R	MED12_ENST00000374102.1_Missense_Mutation_p.G1218R|MED12_ENST00000374080.3_Missense_Mutation_p.G1218R	NM_005120.2	NP_005111.2	Q93074	MED12_HUMAN	mediator complex subunit 12	1218					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(6)|central_nervous_system(2)|endometrium(22)|kidney(5)|large_intestine(8)|lung(31)|ovary(2)|pancreas(1)|prostate(11)|skin(5)|soft_tissue(323)|upper_aerodigestive_tract(1)|urinary_tract(3)	420	Renal(35;0.156)					CATCGTGGATGGAGCCGTGTT	0.577000			"""M, S"""		uterine leiomyoma		Opitz-Kaveggia Syndrome				OREG0019857	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	20					0	0	1	0	0
TMEM255B	348013	broad.mit.edu	37	13	114514838	114514838	+	Missense_Mutation	SNP	T	T	C			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr13:114514838T>C	ENST00000375353.3	+	9	970	c.943T>C	c.(943-945)Ttt>Ctt	p.F315L	TMEM255B_ENST00000467169.1_3'UTR	NM_182614.2	NP_872420.1			transmembrane protein 255B																		ACCCACCTACTTTCCCCCGGG	0.567000													18	75					0	0	1	0	0
GPR133	283383	broad.mit.edu	37	12	131476886	131476886	+	Silent	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr12:131476886C>T	ENST00000261654.5	+	8	1474	c.915C>T	c.(913-915)ctC>ctT	p.L305L	GPR133_ENST00000535015.1_Silent_p.L337L|RP11-76C10.5_ENST00000542980.1_lincRNA	NM_198827.3	NP_942122.2	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133	305					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(2)|endometrium(6)|kidney(1)|large_intestine(12)|lung(20)|ovary(3)|pancreas(6)|prostate(6)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(4)	67	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		ATGTATCCCTCAGCTTACCCA	0.502000													30	86					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7734577	7734577	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr17:7734577C>T	ENST00000572933.1	+	80	13864	c.12404C>T	c.(12403-12405)tCc>tTc	p.S4135F	DNAH2_ENST00000389173.2_Missense_Mutation_p.S4135F			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	4135					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				ACTTTGCTTTCCTTGCAACCT	0.572000													32	158					0	0	1	0	0
SLC46A2	57864	broad.mit.edu	37	9	115652599	115652599	+	Silent	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr9:115652599G>A	ENST00000374228.4	-	1	594	c.363C>T	c.(361-363)ctC>ctT	p.L121L		NM_033051.3	NP_149040.3	Q9BY10	TSCOT_HUMAN	solute carrier family 46, member 2	121						integral to membrane|plasma membrane	symporter activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(11)|pancreas(1)|skin(1)	18						GCAGCAGCCCGAGGCGGGAGA	0.677000													28	12					0	0	1	0	0
KBTBD3	143879	broad.mit.edu	37	11	105923955	105923955	+	Silent	SNP	A	A	G			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr11:105923955A>G	ENST00000526793.1	-	3	1620	c.1461T>C	c.(1459-1461)tcT>tcC	p.S487S	KBTBD3_ENST00000534815.1_Silent_p.S408S|KBTBD3_ENST00000531837.1_Silent_p.S487S	NM_152433.3	NP_689646.2	Q8NAB2	KBTB3_HUMAN	kelch repeat and BTB (POZ) domain containing 3	483										NS(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(9)|lung(6)|ovary(1)|prostate(1)	25		Melanoma(852;0.000878)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0321)		BRCA - Breast invasive adenocarcinoma(274;5.43e-05)|Epithelial(105;0.00418)|all cancers(92;0.0299)		CTACTAGTTCAGACCACTGAT	0.348000													21	8					0	0	1	0	0
SAMHD1	25939	broad.mit.edu	37	20	35579911	35579911	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr20:35579911C>T	ENST00000262878.4	-	1	335	c.136G>A	c.(136-138)Ggt>Agt	p.G46S	SAMHD1_ENST00000373694.5_5'UTR	NM_015474.3	NP_056289.2	Q9Y3Z3	SAMH1_HUMAN	SAM domain and HD domain 1	46	SAM.				defense response to virus|innate immune response|regulation of innate immune response	nucleus	metal ion binding|phosphoric diester hydrolase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(8)|urinary_tract(1)	20		Myeloproliferative disorder(115;0.00878)				TGCTCCGGACCCCATGTCTTG	0.652000													32	148					0	0	1	0	0
ZZEF1	23140	broad.mit.edu	37	17	3936218	3936218	+	Silent	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr17:3936218G>A	ENST00000381638.2	-	41	6787	c.6663C>T	c.(6661-6663)gtC>gtT	p.V2221V		NM_015113.3	NP_055928.3	O43149	ZZEF1_HUMAN	zinc finger, ZZ-type with EF-hand domain 1	2221							calcium ion binding|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	84						AGGTGGCAATGACATCACGCC	0.587000													7	14					0	0	1	0	0
LRRC37A5P	652972	broad.mit.edu	37	9	114371493	114371493	+	RNA	SNP	C	C	T	rs12351897	by1000genomes	TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr9:114371493C>T	ENST00000374304.1	-	0	306																											CTTCTCACATCGTTGTTGGGG	0.502000													6	106					0	0	1	0	0
ERN2	10595	broad.mit.edu	37	16	23718361	23718361	+	Missense_Mutation	SNP	G	G	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr16:23718361G>T	ENST00000256797.4	-	5	658	c.490C>A	c.(490-492)Ccc>Acc	p.P164T	ERN2_ENST00000457008.2_Missense_Mutation_p.P116T	NM_033266.3	NP_150296.3	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signaling 2	116					apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		CTGCGGCAGGGAGAGGCATGA	0.552000													13	27					1.05317e-09	1.15407e-09	1	1	0
TNK2	10188	broad.mit.edu	37	3	195599181	195599181	+	Missense_Mutation	SNP	G	G	C			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr3:195599181G>C	ENST00000333602.6	-	10	2034	c.1417C>G	c.(1417-1419)Cgc>Ggc	p.R473G	TNK2_ENST00000428187.1_Missense_Mutation_p.R505G|TNK2_ENST00000316664.3_Missense_Mutation_p.R473G|TNK2_ENST00000392400.1_Missense_Mutation_p.R473G|TNK2_ENST00000381916.2_Missense_Mutation_p.R536G	NM_005781.4	NP_005772.3	Q07912	ACK1_HUMAN	tyrosine kinase, non-receptor, 2	473				Missing (in Ref. 4; AAH08884).	positive regulation of peptidyl-tyrosine phosphorylation|protein ubiquitination|small GTPase mediated signal transduction	adherens junction|cytoplasmic vesicle membrane|endosome|nucleus	ATP binding|GTPase inhibitor activity|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(11)|ovary(3)|prostate(4)|skin(2)|stomach(1)|urinary_tract(1)	29	all_cancers(143;6.48e-09)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;1.46e-22)|OV - Ovarian serous cystadenocarcinoma(49;8.3e-19)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;0.000757)	Adenosine triphosphate(DB00171)	CAGCAGTGGCGGGGGTCACTG	0.677000													8	18					0	0	1	0	0
DSC1	1823	broad.mit.edu	37	18	28737511	28737511	+	Silent	SNP	C	C	G	rs147816863		TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr18:28737511C>G	ENST00000257197.3	-	3	435	c.174G>C	c.(172-174)tcG>tcC	p.S58S	RP11-408H20.2_ENST00000581836.1_RNA|DSC1_ENST00000257198.5_Silent_p.S58S	NM_004948.3	NP_004939.1	Q08554	DSC1_HUMAN	desmocollin 1	58					homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(20)|ovary(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			TTAGGCTGGCCGACTTGAGAC	0.448000													14	43					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10099815	10099815	+	Silent	SNP	T	T	C			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr19:10099815T>C	ENST00000264828.3	-	27	2215	c.2130A>G	c.(2128-2130)ggA>ggG	p.G710G		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	710	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			CTCCCCGAGGTCCAGGATAGC	0.542000													28	50					0	0	1	0	0
FAM213B	127281	broad.mit.edu	37	1	2520046	2520046	+	Silent	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr1:2520046C>T	ENST00000378424.4	+	5	602	c.586C>T	c.(586-588)Ctg>Ttg	p.L196L	FAM213B_ENST00000444521.2_Silent_p.L166L|FAM213B_ENST00000537325.1_Intron|FAM213B_ENST00000378425.5_Silent_p.L148L|FAM213B_ENST00000419916.2_Silent_p.L178L|FAM213B_ENST00000484099.1_3'UTR			Q8TBF2	PGFS_HUMAN	family with sequence similarity 213, member B	148					prostaglandin biosynthetic process	cytosol	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor										GAGCGGAGGGCTGCTGGTGGT	0.632000													30	79					0	0	1	0	0
ACTL6B	51412	broad.mit.edu	37	7	100244899	100244899	+	Silent	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr7:100244899G>A	ENST00000160382.5	-	9	874	c.768C>T	c.(766-768)atC>atT	p.I256I		NM_016188.4	NP_057272.1	O94805	ACL6B_HUMAN	actin-like 6B	256					chromatin modification|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nBAF complex|SWI/SNF complex	ATP binding|protein binding|structural constituent of cytoskeleton			endometrium(1)|large_intestine(3)|lung(7)|ovary(1)|skin(1)	13	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					GGAAGTCCTGGATCACCTCCT	0.672000													22	23					0	0	1	0	0
PSD2	84249	broad.mit.edu	37	5	139193876	139193876	+	Missense_Mutation	SNP	C	C	G			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr5:139193876C>G	ENST00000274710.3	+	4	1148	c.943C>G	c.(943-945)Cat>Gat	p.H315D		NM_032289.2	NP_115665.1	Q9BQI7	PSD2_HUMAN	pleckstrin and Sec7 domain containing 2	315	SEC7.				regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity	p.H315Y(1)		breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(10)|liver(2)|lung(15)|ovary(1)|prostate(2)	38			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGAAGCTGCTCATCGGCTGGC	0.647000													22	38					0	0	1	0	0
BRWD1	54014	broad.mit.edu	37	21	40569194	40569194	+	Missense_Mutation	SNP	G	G	A	rs145664878		TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr21:40569194G>A	ENST00000342449.3	-	41	5879	c.5801C>T	c.(5800-5802)aCg>aTg	p.T1934M	BRWD1_ENST00000333229.2_Missense_Mutation_p.T1934M|BRWD1_ENST00000380800.3_Missense_Mutation_p.T1934M	NM_033656.3	NP_387505.1	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	1934					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				cervix(2)|endometrium(6)|kidney(8)|large_intestine(14)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(2)	58		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				ATTGGCAGCCGTAGCTGCACA	0.423000													56	29					0	0	1	0	0
MRPS10	55173	broad.mit.edu	37	6	42179605	42179605	+	Missense_Mutation	SNP	C	C	G			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr6:42179605C>G	ENST00000053468.3	-	4	252	c.237G>C	c.(235-237)ttG>ttC	p.L79F		NM_018141.3	NP_060611.2	P82664	RT10_HUMAN	mitochondrial ribosomal protein S10	79					translation	actin cytoskeleton|mitochondrion|ribosome	structural constituent of ribosome			endometrium(1)|lung(1)	2	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|Epithelial(12;0.00528)			GACCTTTCACCAAAACCGAGA	0.363000													28	48					0	0	1	0	0
NOA1	84273	broad.mit.edu	37	4	57842668	57842668	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr4:57842668C>T	ENST00000264230.4	-	1	2321	c.1084G>A	c.(1084-1086)Gat>Aat	p.D362N		NM_032313.2	NP_115689.1	Q8NC60	CD014_HUMAN	nitric oxide associated 1	362							GTP binding										GTGCAGTAATCGGACTCCAGG	0.607000													14	14					0	0	1	0	0
KHSRP	8570	broad.mit.edu	37	19	6418059	6418059	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr19:6418059C>T	ENST00000398148.3	-	10	1003	c.911G>A	c.(910-912)cGg>cAg	p.R304Q		NM_003685.2	NP_003676.2	Q92945	FUBP2_HUMAN	KH-type splicing regulatory protein	304	Gly-rich.				mRNA processing|mRNA transport|regulation of transcription, DNA-dependent|RNA splicing, via transesterification reactions|transcription, DNA-dependent	cytosol|nucleus	DNA binding|protein binding|RNA binding			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(3)|liver(1)|lung(6)|skin(1)|soft_tissue(1)	17						GTCACGTTCCCGGAGGATGTC	0.642000											OREG0025200	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	21					0	0	1	0	0
KIAA0430	9665	broad.mit.edu	37	16	15705592	15705592	+	Splice_Site	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr16:15705592C>T	ENST00000396368.3	-	18	3681		c.e18-1		KIAA0430_ENST00000551742.1_Splice_Site|KIAA0430_ENST00000344181.3_Splice_Site|KIAA0430_ENST00000548025.1_Splice_Site|KIAA0430_ENST00000602337.1_Splice_Site|KIAA0430_ENST00000540441.2_Splice_Site	NM_001184998.1|NM_001184999.1|NM_014647.3	NP_001171927.1|NP_001171928.1|NP_055462.2	Q9Y4F3	LKAP_HUMAN	KIAA0430							peroxisome	nucleotide binding|RNA binding			breast(4)|endometrium(8)|kidney(4)|large_intestine(2)|lung(13)|ovary(3)|prostate(5)|skin(1)	40						TTCCAAGAATCTGCAAAGCAA	0.488000													24	26					0	0	1	0	0
BRCA2	675	broad.mit.edu	37	13	32900694	32900694	+	Missense_Mutation	SNP	T	T	C	rs80358805		TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr13:32900694T>C	ENST00000544455.1	+	7	802	c.575T>C	c.(574-576)aTg>aCg	p.M192T	BRCA2_ENST00000380152.3_Missense_Mutation_p.M192T	NM_000059.3	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	192			M -> T (in one patient with pancreatic cancer).		cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			NS(3)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(32)|liver(1)|lung(41)|oesophagus(5)|ovary(22)|pancreas(4)|prostate(3)|salivary_gland(1)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	183		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		GATCCTGATATGTCTTGGTCA	0.393000			"""D, Mis, N, F, S"""		"""breast, ovarian, pancreatic"""	"""breast, ovarian, pancreatic, leukemia  (FANCB, FANCD1)"""		Homologous recombination	Pancreatic Cancer, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Prostate Cancer;Hereditary Breast-Ovarian Cancer, BRCA2 type;Fanconi Anemia type D1, bi-allelic BRCA2 mutations;Fanconi Anemia	TCGA Ovarian(8;0.087)			45	37					0	0	1	0	0
MYOZ1	58529	broad.mit.edu	37	10	75391746	75391746	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr10:75391746G>A	ENST00000359322.4	-	6	1206	c.842C>T	c.(841-843)cCt>cTt	p.P281L		NM_021245.3	NP_067068.1	Q9NP98	MYOZ1_HUMAN	myozenin 1	281					myofibril assembly	nucleus|pseudopodium	FATZ binding			central_nervous_system(1)|large_intestine(5)|lung(2)|ovary(2)|skin(2)	12	Prostate(51;0.0112)					GTAGTCTACAGGCTCCCCAGA	0.532000													21	32					0	0	1	0	0
CRCT1	54544	broad.mit.edu	37	1	152487972	152487972	+	Missense_Mutation	SNP	C	C	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr1:152487972C>A	ENST00000368790.3	+	2	186	c.113C>A	c.(112-114)tCc>tAc	p.S38Y		NM_019060.2	NP_061933.1	Q9UGL9	CRCT1_HUMAN	cysteine-rich C-terminal 1	38										lung(1)|ovary(1)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			tcctcctcctccTGCTGCGGC	0.736000													6	10					0.27861	0.280141	1	1	0
RNLS	55328	broad.mit.edu	37	10	90034726	90034726	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr10:90034726G>A	ENST00000371947.3	-	7	2279	c.940C>T	c.(940-942)Ccc>Tcc	p.P314S	RNLS_ENST00000437752.1_Missense_Mutation_p.P231S	NM_018363.3	NP_060833.1	Q5VYX0	RNLS_HUMAN	renalase, FAD-dependent amine oxidase	0						extracellular region	oxidoreductase activity			breast(1)|kidney(1)|lung(3)|ovary(1)|prostate(1)	7						AGTCAGATGGGAAATCCAATC	0.418000													10	40					0	0	1	0	0
ATF6	22926	broad.mit.edu	37	1	161771931	161771931	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr1:161771931G>A	ENST00000367942.3	+	7	845	c.778G>A	c.(778-780)Ggg>Agg	p.G260R		NM_007348.3	NP_031374.2	P18850	ATF6A_HUMAN	activating transcription factor 6	260					positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response|protein folding	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(8)|lung(14)|ovary(3)|skin(1)|stomach(1)	34	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.00953)			TGCTGTTGCTGGGGGAGTCAC	0.532000													23	71					0	0	1	0	0
TEX15	56154	broad.mit.edu	37	8	30702216	30702216	+	Missense_Mutation	SNP	C	C	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr8:30702216C>A	ENST00000256246.2	-	1	4392	c.4318G>T	c.(4318-4320)Gat>Tat	p.D1440Y		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	1440										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		TTTACATTATCTTTTAAAAGC	0.348000													8	28					0.000157383	0.0001609	1	1	0
GJB4	127534	broad.mit.edu	37	1	35227230	35227230	+	Silent	SNP	C	C	T	rs147830069		TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr1:35227230C>T	ENST00000339480.1	+	2	745	c.375C>T	c.(373-375)ggC>ggT	p.G125G	RP1-34M23.5_ENST00000542839.1_RNA	NM_153212.2	NP_694944.1	Q9NTQ9	CXB4_HUMAN	gap junction protein, beta 4, 30.3kDa	125					cell communication	connexon complex|integral to membrane	gap junction channel activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(6)|ovary(2)|skin(1)	16		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.234)				AGAAGCGGGGCGGACTGTGGT	0.592000													14	28					0	0	1	0	0
TDRD9	122402	broad.mit.edu	37	14	104471727	104471727	+	Silent	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr14:104471727C>T	ENST00000409874.4	+	15	1746	c.1698C>T	c.(1696-1698)atC>atT	p.I566I	TDRD9_ENST00000339063.5_Silent_p.I566I	NM_153046.2	NP_694591.2	Q8NDG6	TDRD9_HUMAN	tudor domain containing 9	566					cell differentiation|DNA methylation involved in gamete generation|fertilization|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	nucleus|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	33		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0768)				AGCGCACCATCCTTCTACTAA	0.532000													14	26					0	0	1	0	0
SPIN4	139886	broad.mit.edu	37	X	62570455	62570455	+	Missense_Mutation	SNP	C	C	G			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chrX:62570455C>G	ENST00000374884.2	-	1	768	c.190G>C	c.(190-192)Gat>Cat	p.D64H	SPIN4_ENST00000335144.3_Missense_Mutation_p.D82H|SPIN4-AS1_ENST00000451979.1_RNA			Q56A73	SPIN4_HUMAN	spindlin family, member 4	82					gamete generation					endometrium(1)|large_intestine(1)|lung(7)|ovary(1)|upper_aerodigestive_tract(1)	11						TACACACTATCTTTGCCATCA	0.498000													4	17					0	0	1	0	0
SMARCA1	6594	broad.mit.edu	37	X	128638781	128638781	+	Splice_Site	SNP	T	T	C			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chrX:128638781T>C	ENST00000371122.4	-	9	1228		c.e9-2		SMARCA1_ENST00000371121.3_Splice_Site|SMARCA1_ENST00000371123.1_Splice_Site	NM_003069.3	NP_003060.2	P28370	SMCA1_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1						ATP-dependent chromatin remodeling|brain development|neuron differentiation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	NURF complex	ATP binding|DNA binding|helicase activity|nucleosome binding|protein binding			biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(13)|ovary(5)|prostate(1)|skin(1)	45						ATCAAAGTCCTGTAGAGGGGT	0.343000													26	36					0	0	1	0	0
SLC6A3	6531	broad.mit.edu	37	5	1406324	1406324	+	Silent	SNP	C	C	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr5:1406324C>A	ENST00000270349.9	-	12	1705	c.1578G>T	c.(1576-1578)ctG>ctT	p.L526L	SLC6A3_ENST00000453492.2_Silent_p.L526L	NM_001044.4	NP_001035.1	Q01959	SC6A3_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 3	526					cell death|neurotransmitter biosynthetic process	axon|cytoplasm|integral to plasma membrane|neuronal cell body				breast(2)|endometrium(4)|kidney(1)|large_intestine(3)|lung(19)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	38			OV - Ovarian serous cystadenocarcinoma(19;0.00928)|all cancers(22;0.0262)		Amphetamine(DB00182)|Benztropine(DB00245)|Bupropion(DB01156)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dextroamphetamine(DB01576)|Diethylpropion(DB00937)|Duloxetine(DB00476)|Fencamfamine(DB01463)|Mazindol(DB00579)|Methylphenidate(DB00422)|Modafinil(DB00745)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Procaine(DB00721)	AGGGGCTGACCAGCTTCCAGC	0.672000													36	52					2.42023e-17	2.75095e-17	1	1	0
PWWP2A	114825	broad.mit.edu	37	5	159520621	159520621	+	Missense_Mutation	SNP	A	A	G			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr5:159520621A>G	ENST00000456329.3	-	2	1070	c.1036T>C	c.(1036-1038)Tct>Cct	p.S346P	PWWP2A_ENST00000523662.1_Missense_Mutation_p.S346P|PWWP2A_ENST00000307063.7_Missense_Mutation_p.S346P	NM_052927.2	NP_443159.1	Q96N64	PWP2A_HUMAN	PWWP domain containing 2A	346										kidney(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCATATTTAGAAGAGTCAGTT	0.328000													9	32					0	0	1	0	0
BAMBI	25805	broad.mit.edu	37	10	28970934	28970934	+	Missense_Mutation	SNP	T	T	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr10:28970934T>A	ENST00000375533.3	+	3	943	c.387T>A	c.(385-387)caT>caA	p.H129Q		NM_012342.2	NP_036474.1	Q13145	BAMBI_HUMAN	BMP and activin membrane-bound inhibitor	129					cell migration|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of cell proliferation|positive regulation of epithelial to mesenchymal transition|positive regulation of protein binding|positive regulation of transcription, DNA-dependent|regulation of cell shape	cytoplasm|integral to membrane|plasma membrane	frizzled binding|type II transforming growth factor beta receptor binding			central_nervous_system(5)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|prostate(1)|skin(1)	17						GGTATCAGCATGATGGTAGCA	0.453000													38	67					0	0	1	0	0
SLC35E4	339665	broad.mit.edu	37	22	31032724	31032724	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr22:31032724G>A	ENST00000343605.4	+	1	1086	c.287G>A	c.(286-288)cGg>cAg	p.R96Q	SLC35E4_ENST00000406566.1_Missense_Mutation_p.R96Q|SLC35E4_ENST00000300385.8_Missense_Mutation_p.R96Q	NM_001001479.2	NP_001001479.1	Q6ICL7	S35E4_HUMAN	solute carrier family 35, member E4	96						integral to membrane				autonomic_ganglia(1)|endometrium(1)|large_intestine(2)|lung(3)|ovary(1)|pancreas(1)|skin(1)	10						GCATGCCACCGGGGGGCACGG	0.662000													12	3					0	0	1	0	0
ATM	472	broad.mit.edu	37	11	108115703	108115703	+	Missense_Mutation	SNP	A	A	C			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr11:108115703A>C	ENST00000278616.4	+	7	1236	c.851A>C	c.(850-852)cAa>cCa	p.Q284P	ATM_ENST00000452508.2_Missense_Mutation_p.Q284P	NM_000051.3	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated	284					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			NS(4)|breast(23)|central_nervous_system(11)|endometrium(10)|haematopoietic_and_lymphoid_tissue(227)|kidney(19)|large_intestine(53)|liver(5)|lung(62)|ovary(6)|pancreas(4)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	448		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		GAATTATTTCAACTGCAAATT	0.308000			"""D, Mis, N, F, S"""		T-PLL	"""leukemia, lymphoma, medulloblastoma, glioma"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Ataxia Telangiectasia	TSP Lung(14;0.12)			22	20					0	0	1	0	0
ADAM22	53616	broad.mit.edu	37	7	87762258	87762258	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr7:87762258G>A	ENST00000398204.4	+	12	1392	c.1069G>A	c.(1069-1071)Gtg>Atg	p.V357M	ADAM22_ENST00000265727.7_Missense_Mutation_p.V357M|ADAM22_ENST00000315984.7_Missense_Mutation_p.V357M|ADAM22_ENST00000398201.4_Missense_Mutation_p.V357M|ADAM22_ENST00000398209.3_Missense_Mutation_p.V357M	NM_016351.4|NM_021723.3	NP_057435.2|NP_068369.1	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22	357	Peptidase M12B.				cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			endometrium(7)|kidney(4)|large_intestine(7)|liver(2)|lung(20)|ovary(6)|prostate(4)|skin(3)	53	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			AGGAGGAGGCGTGAATGAAGT	0.398000													5	70					0	0	1	0	0
CETN2	1069	broad.mit.edu	37	X	151997114	151997114	+	Missense_Mutation	SNP	C	C	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chrX:151997114C>A	ENST00000370277.3	-	4	462	c.396G>T	c.(394-396)gaG>gaT	p.E132D	CETN2_ENST00000493482.1_5'UTR	NM_004344.1	NP_004335.1	P41208	CETN2_HUMAN	centrin, EF-hand protein, 2	132	EF-hand 3.				cell division|centriole replication|G2/M transition of mitotic cell cycle|mitosis|nucleotide-excision repair|regulation of cytokinesis	centriole|cytosol|XPC complex	ATP binding|ATP-dependent helicase activity|calcium ion binding|nucleic acid binding			breast(1)|lung(4)|prostate(1)|skin(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					TCTCACCCAACTCCTTGGCCA	0.418000								Direct reversal of damage;Nucleotide excision repair (NER)					28	35					1.68575e-08	1.81467e-08	1	1	0
KIAA0368	23392	broad.mit.edu	37	9	114151916	114151916	+	Missense_Mutation	SNP	G	G	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr9:114151916G>T	ENST00000259335.4	-	32	3900	c.3901C>A	c.(3901-3903)Cgt>Agt	p.R1301S	KIAA0368_ENST00000374378.3_5'UTR|KIAA0368_ENST00000338205.5_Missense_Mutation_p.R1123S	NM_001080398.1	NP_001073867.1			KIAA0368											NS(2)|breast(3)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(23)|prostate(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	65						AACTGGTAACGATAAAGTCGA	0.453000													17	23					2.23348e-06	2.33559e-06	1	1	0
FAHD2A	51011	broad.mit.edu	37	2	96072867	96072867	+	Missense_Mutation	SNP	G	G	C			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr2:96072867G>C	ENST00000233379.4	+	3	577	c.424G>C	c.(424-426)Ggg>Cgg	p.G142R	FAHD2A_ENST00000447036.1_Missense_Mutation_p.G142R	NM_016044.2	NP_057128.2	Q96GK7	FAH2A_HUMAN	fumarylacetoacetate hydrolase domain containing 2A	142							hydrolase activity|metal ion binding			breast(1)|cervix(1)|endometrium(1)|kidney(1)|lung(3)|ovary(1)	8						CTCCATCGTGGGGCCCTATGA	0.577000													32	45					0	0	1	0	0
COL2A1	1280	broad.mit.edu	37	12	48375154	48375154	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr12:48375154G>A	ENST00000380518.3	-	37	2599	c.2435C>T	c.(2434-2436)gCa>gTa	p.A812V	COL2A1_ENST00000337299.6_Missense_Mutation_p.A743V|COL2A1_ENST00000493991.1_5'UTR	NM_001844.4|NM_033150.2	NP_001835.3|NP_149162.2	P02458	CO2A1_HUMAN	collagen, type II, alpha 1	812	Triple-helical region.				axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(25)|ovary(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(3)	64		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	AGCACTTCCTGCAGGACCAGG	0.637000													4	9					0	0	1	0	0
CHGB	1114	broad.mit.edu	37	20	5904525	5904525	+	Missense_Mutation	SNP	G	G	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr20:5904525G>T	ENST00000378961.4	+	4	1939	c.1735G>T	c.(1735-1737)Gat>Tat	p.D579Y		NM_001819.2	NP_001810.2	P05060	SCG1_HUMAN	chromogranin B (secretogranin 1)	579						extracellular region	hormone activity			breast(7)|kidney(2)|large_intestine(8)|lung(19)|ovary(1)|pancreas(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	47						CTTCTCTGAGGATGTGAACTG	0.502000													15	52					4.14922e-12	4.57414e-12	1	1	0
RSBN1	54665	broad.mit.edu	37	1	114340631	114340631	+	Missense_Mutation	SNP	T	T	C			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr1:114340631T>C	ENST00000261441.5	-	2	794	c.731A>G	c.(730-732)cAg>cGg	p.Q244R		NM_018364.3	NP_060834.2	Q5VWQ0	RSBN1_HUMAN	round spermatid basic protein 1	244						nucleus				breast(1)|endometrium(2)|large_intestine(4)|lung(16)|ovary(1)|prostate(3)|urinary_tract(2)	29	Lung SC(450;0.184)	all_cancers(81;3.78e-08)|all_epithelial(167;5.56e-08)|all_lung(203;6.97e-06)|Lung NSC(69;1.18e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		ATCGGCTCTCTGGGTTTTACC	0.358000													44	71					0	0	1	0	0
LPAR6	10161	broad.mit.edu	37	13	48985612	48985612	+	Silent	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr13:48985612G>A	ENST00000378434.4	-	7	2572	c.948C>T	c.(946-948)ttC>ttT	p.F316F	RB1_ENST00000267163.4_Intron|LPAR6_ENST00000345941.2_Silent_p.F316F	NM_005767.5	NP_005758.2	P43657	LPAR6_HUMAN	lysophosphatidic acid receptor 6	316						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled	p.0?(15)|p.?(4)		NS(1)|endometrium(1)|large_intestine(4)|lung(1)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	14						GAACTTCAGAGAATCTGAAGT	0.338000													24	87					0	0	1	0	0
ARHGAP6	395	broad.mit.edu	37	X	11206894	11206894	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chrX:11206894G>A	ENST00000337414.4	-	4	1903	c.1031C>T	c.(1030-1032)tCa>tTa	p.S344L	ARHGAP6_ENST00000534860.1_Missense_Mutation_p.S169L|ARHGAP6_ENST00000413512.3_Missense_Mutation_p.S153L|ARHGAP6_ENST00000380732.3_Missense_Mutation_p.S376L|ARHGAP6_ENST00000380736.1_Missense_Mutation_p.S141L|ARHGAP6_ENST00000380718.1_Missense_Mutation_p.S344L|ARHGAP6_ENST00000303025.6_Missense_Mutation_p.S141L	NM_013427.2	NP_038286.2	O43182	RHG06_HUMAN	Rho GTPase activating protein 6	344					actin filament polymerization|activation of phospholipase C activity|negative regulation of focal adhesion assembly|negative regulation of stress fiber assembly|Rho protein signal transduction	actin filament|cytosol	phospholipase activator activity|phospholipase binding|Rho GTPase activator activity|SH3 domain binding|SH3/SH2 adaptor activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(19)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38						TGGGGACGTTGACTCATTCGG	0.498000													19	40					0	0	1	0	0
MLNR	2862	broad.mit.edu	37	13	49795318	49795318	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr13:49795318G>A	ENST00000398307.1	+	1	845	c.845G>A	c.(844-846)cGa>cAa	p.R282Q	MLNR_ENST00000218721.1_Missense_Mutation_p.R282Q			O43193	MTLR_HUMAN	motilin receptor	282					digestion	integral to plasma membrane	growth hormone-releasing hormone receptor activity			endometrium(3)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)	14		all_lung(13;8.31e-06)|Lung NSC(96;0.000251)|Breast(56;0.0008)|Prostate(109;0.00446)|Hepatocellular(98;0.0556)|Glioma(44;0.236)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;6.1e-09)		CGGCCGCTGCGAGGCCCGGCC	0.701000													20	4					0	0	1	0	0
FAM86EP	348926	broad.mit.edu	37	4	3954857	3954857	+	RNA	SNP	C	C	A	rs17410899		TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr4:3954857C>A	ENST00000281228.8	-	0	141				FAM86EP_ENST00000313946.8_RNA																							AATATCCCGCCGCAGCTCAGA	0.488000													4	62					3.59834e-05	3.72031e-05	1	1	0
ZNF37A	7587	broad.mit.edu	37	10	38407098	38407098	+	Nonsense_Mutation	SNP	C	C	G			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr10:38407098C>G	ENST00000361085.5	+	7	1364	c.1019C>G	c.(1018-1020)tCa>tGa	p.S340*	ZNF37A_ENST00000351773.3_Nonsense_Mutation_p.S340*	NM_001178101.1|NM_003421.2	NP_001171572.1|NP_003412.1	P17032	ZN37A_HUMAN	zinc finger protein 37A							nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(13)|prostate(1)	28						AGTGAAAAGTCAACCCTTACT	0.393000													37	90					0	0	1	0	0
VIT	5212	broad.mit.edu	37	2	37032673	37032673	+	Missense_Mutation	SNP	G	G	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr2:37032673G>T	ENST00000379242.3	+	14	1557	c.1255G>T	c.(1255-1257)Ggc>Tgc	p.G419C	VIT_ENST00000389975.3_Missense_Mutation_p.G404C|VIT_ENST00000404084.1_Missense_Mutation_p.G356C|VIT_ENST00000401530.1_Missense_Mutation_p.G383C|VIT_ENST00000379241.3_Missense_Mutation_p.G382C|VIT_ENST00000497382.1_Missense_Mutation_p.G73C	NM_053276.3	NP_444506.2	Q6UXI7	VITRN_HUMAN	vitrin	404	VWFA 1.			E -> V (in Ref. 1; AAL18263).		proteinaceous extracellular matrix				autonomic_ganglia(1)|breast(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	57		all_hematologic(82;0.248)				GATGGTGGATGGCTGGCCCAC	0.502000													23	106					2.39556e-15	2.6731e-15	1	1	0
GLI3	2737	broad.mit.edu	37	7	42005031	42005031	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr7:42005031G>A	ENST00000395925.3	-	15	3724	c.3640C>T	c.(3640-3642)Cag>Tag	p.Q1214*	GLI3_ENST00000479210.1_5'UTR	NM_000168.5	NP_000159.3	P10071	GLI3_HUMAN	GLI family zinc finger 3	1214					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|biliary_tract(1)|breast(4)|central_nervous_system(2)|endometrium(12)|kidney(7)|large_intestine(25)|lung(49)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	112						CCGAGGGTCTGATAGCCCCCA	0.652000									Pallister-Hall syndrome;Greig Cephalopolysyndactyly				47	69					0	0	1	0	0
AGRN	375790	broad.mit.edu	37	1	957650	957650	+	Missense_Mutation	SNP	A	A	G			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr1:957650A>G	ENST00000379370.2	+	2	321	c.271A>G	c.(271-273)Aag>Gag	p.K91E		NM_198576.3	NP_940978.2	O00468	AGRIN_HUMAN	agrin	91	NtA.				axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			breast(1)|central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(2)|lung(20)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	42	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		CGGCGGCAACAAGGTGGTGAT	0.602000													37	78					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82580339	82580339	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr7:82580339C>T	ENST00000333891.9	-	6	9902	c.9565G>A	c.(9565-9567)Gaa>Aaa	p.E3189K	PCLO_ENST00000423517.2_Missense_Mutation_p.E3189K	NM_033026.5	NP_149015.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein		Gln-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						GGAAACACTTCGGATGCTGTG	0.443000													12	18					0	0	1	0	0
LOC220729	220729	broad.mit.edu	37	3	197348646	197348646	+	RNA	SNP	T	T	C	rs138265355	by1000genomes	TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr3:197348646T>C	ENST00000418868.1	-	0	613					NR_003266.2																						TGGGCCTGCCTGCCCTTTCCA	0.532000													6	67					0	0	1	0	0
CMTR1	23070	broad.mit.edu	37	6	37429339	37429339	+	Silent	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr6:37429339G>A	ENST00000373451.4	+	11	1274	c.1110G>A	c.(1108-1110)gaG>gaA	p.E370E	CMTR1_ENST00000493656.1_3'UTR	NM_015050.2	NP_055865.1			cap methyltransferase 1	370								p.E370D(1)									TCTCGGTGGAGGGGCAGGAGA	0.512000													5	31					0	0	1	0	0
KANK3	256949	broad.mit.edu	37	19	8398105	8398105	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr19:8398105G>A	ENST00000330915.3	-	7	1794	c.1729C>T	c.(1729-1731)Cgc>Tgc	p.R577C	KANK3_ENST00000593649.1_Missense_Mutation_p.R577C	NM_198471.2	NP_940873.2	Q6NY19	KANK3_HUMAN	KN motif and ankyrin repeat domains 3	577										breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|skin(1)|urinary_tract(1)	9						GCCACGAGGCGCACTGCGCCC	0.706000													3	24					0	0	1	0	0
MICB	4277	broad.mit.edu	37	6	31477644	31477644	+	Silent	SNP	G	G	C			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr6:31477644G>C	ENST00000252229.6	+	6	1189	c.1110G>C	c.(1108-1110)ctG>ctC	p.L370L	MICB_ENST00000538442.1_Silent_p.L338L|MICB_ENST00000399150.3_Silent_p.L327L	NM_005931.3	NP_005922.2	Q29980	MICB_HUMAN	MHC class I polypeptide-related sequence B	370					antigen processing and presentation|cytolysis|gamma-delta T cell activation|immune response|immune response-activating cell surface receptor signaling pathway|interspecies interaction between organisms|negative regulation of defense response to virus by host|response to heat|response to oxidative stress|response to retinoic acid	integral to plasma membrane|MHC class I protein complex	natural killer cell lectin-like receptor binding			NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)	13						TTCAGCCTCTGATGTCAGCTA	0.577000													39	54					0	0	1	0	0
ARHGAP35	2909	broad.mit.edu	37	19	47422438	47422438	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr19:47422438G>A	ENST00000404338.3	+	1	506	c.506G>A	c.(505-507)gGc>gAc	p.G169D		NM_004491.4	NP_004482.4	Q9NRY4	RHG35_HUMAN	Rho GTPase activating protein 35	169					axon guidance|negative regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol	DNA binding|Rho GTPase activator activity|transcription corepressor activity										GTTAGCAGGGGCATGAATAGG	0.458000													30	37					0	0	1	0	0
KMT2B	9757	broad.mit.edu	37	19	36229445	36229445	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr19:36229445G>A	ENST00000420124.1	+	37	8135	c.8135G>A	c.(8134-8136)cGg>cAg	p.R2712Q	KMT2B_ENST00000607650.1_RNA|KMT2B_ENST00000222270.7_Missense_Mutation_p.R2712Q					lysine (K)-specific methyltransferase 2B																		CGCTGCCGTCGGTTCCTTAAC	0.652000													6	8					0	0	1	0	0
LRTM2	654429	broad.mit.edu	37	12	1940432	1940432	+	Silent	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr12:1940432G>A	ENST00000543818.1	+	4	1241	c.399G>A	c.(397-399)agG>agA	p.R133R	LRTM2_ENST00000535041.1_Silent_p.R133R|CACNA2D4_ENST00000586184.1_Intron|CACNA2D4_ENST00000587995.1_Intron|CACNA2D4_ENST00000382722.5_Intron|LRTM2_ENST00000543730.1_Intron|CACNA2D4_ENST00000585708.1_Intron|LRTM2_ENST00000299194.1_Silent_p.R133R|CACNA2D4_ENST00000588077.1_Intron|CACNA2D4_ENST00000585732.1_Intron	NM_001039029.2|NM_001163925.1|NM_001163926.1	NP_001034118.1|NP_001157397.1|NP_001157398.1	Q8N967	LRTM2_HUMAN	leucine-rich repeats and transmembrane domains 2	133						integral to membrane				NS(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	20	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.000834)			CCCTGGACAGGGACCTGCTGC	0.637000											OREG0005740	type=TRANSCRIPTION FACTOR BINDING SITE|Gene=CACNA2D4|TFbs=REST|Dataset=NRSF/REST ChIPSeq sites|EvidenceSubtype=Chromatin immunoprecipitation with tag sequencing (ChIP-TS)	12	61					0	0	1	0	0
RAB37	326624	broad.mit.edu	37	17	72741012	72741012	+	Splice_Site	SNP	G	G	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr17:72741012G>T	ENST00000340415.3	+	7	1421	c.412G>T	c.(412-414)Gcg>Tcg	p.A138S	RAB37_ENST00000528438.1_Splice_Site_p.A118S|RAB37_ENST00000392614.4_Splice_Site_p.A150S|RAB37_ENST00000392612.3_Splice_Site_p.A108S|RAB37_ENST00000392610.1_Splice_Site_p.A145S|RAB37_ENST00000392613.5_Splice_Site_p.A145S|RAB37_ENST00000392615.5_Splice_Site_p.A113S|RAB37_ENST00000402449.4_Splice_Site_p.A138S	NM_175738.4	NP_783865.1	Q96AX2	RAB37_HUMAN	RAB37, member RAS oncogene family	145					protein transport|small GTPase mediated signal transduction	ER-Golgi intermediate compartment	GTP binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)	12						GGCTTGACAGGCGGATATGAG	0.617000											OREG0024716	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	32					8.28177e-16	9.29794e-16	1	1	0
SCNN1G	6340	broad.mit.edu	37	16	23224042	23224042	+	Missense_Mutation	SNP	G	G	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr16:23224042G>T	ENST00000300061.2	+	9	1481	c.1338G>T	c.(1336-1338)gaG>gaT	p.E446D	CTC-391G2.1_ENST00000563471.1_RNA	NM_001039.3	NP_001030.2	P51170	SCNNG_HUMAN	sodium channel, non-voltage-gated 1, gamma subunit	446					excretion|sensory perception of taste	apical plasma membrane|integral to plasma membrane	ligand-gated sodium channel activity|WW domain binding			NS(2)|autonomic_ganglia(1)|breast(1)|cervix(2)|kidney(1)|large_intestine(9)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	34				GBM - Glioblastoma multiforme(48;0.0366)	Amiloride(DB00594)|Triamterene(DB00384)	TCCAGGAAGAGCTGGGCTGCC	0.587000													18	71					4.96729e-08	5.31587e-08	1	1	0
POM121L12	285877	broad.mit.edu	37	7	53103824	53103824	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr7:53103824C>T	ENST00000408890.4	+	1	476	c.460C>T	c.(460-462)Cct>Tct	p.P154S		NM_182595.3	NP_872401.3	Q8N7R1	P1L12_HUMAN	POM121 transmembrane nucleoporin-like 12	154										endometrium(5)|kidney(1)|large_intestine(5)|lung(44)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	61						CTGGAGATCCCCTGGACAGAG	0.726000													13	27					0	0	1	0	0
HIST2H2BB	338391	broad.mit.edu	37	1	149376783	149376783	+	RNA	SNP	C	C	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr1:149376783C>A	ENST00000415338.1	-	0	1061				HIST2H2BB_ENST00000609585.1_RNA																							GCCTGGTTTGCAGCTTTACTT	0.507000													8	51					0.00307968	0.00313101	1	1	0
ITGA2B	3674	broad.mit.edu	37	17	42462976	42462976	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr17:42462976C>T	ENST00000262407.5	-	4	548	c.517G>A	c.(517-519)Gag>Aag	p.E173K	ITGA2B_ENST00000353281.4_Missense_Mutation_p.E173K	NM_000419.3	NP_000410.2	P08514	ITA2B_HUMAN	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	173					axon guidance|integrin-mediated signaling pathway|platelet activation|platelet degranulation	integrin complex|platelet alpha granule membrane	identical protein binding|receptor activity			biliary_tract(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(8)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.191)	Tirofiban(DB00775)	GGGGAGTACTCGGCGCGGCGG	0.617000													5	5					0	0	1	0	0
OR56B4	196335	broad.mit.edu	37	11	6129922	6129922	+	Missense_Mutation	SNP	T	T	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr11:6129922T>A	ENST00000316529.3	+	1	1009	c.914T>A	c.(913-915)cTg>cAg	p.L305Q	RP11-290F24.3_ENST00000529961.1_RNA	NM_001005181.1	NP_001005181.1	Q8NH76	O56B4_HUMAN	olfactory receptor, family 56, subfamily B, member 4	305					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|lung(10)|skin(6)|urinary_tract(2)	21		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.31e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AAACTCAGACTGGGCTTTCAG	0.488000													57	51					0	0	1	0	0
MPHOSPH10	10199	broad.mit.edu	37	2	71368431	71368431	+	Missense_Mutation	SNP	T	T	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr2:71368431T>A	ENST00000244230.2	+	7	1730	c.1378T>A	c.(1378-1380)Tta>Ata	p.L460I		NM_005791.2	NP_005782.1	O00566	MPP10_HUMAN	M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)	460					RNA splicing, via transesterification reactions|rRNA processing	chromosome|nucleolus|small nucleolar ribonucleoprotein complex	protein binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(2)|pancreas(2)|skin(2)|stomach(1)	26						GCGTTTAACCTTAGACCATGA	0.378000													89	180					0	0	1	0	0
GDNF	2668	broad.mit.edu	37	5	37834771	37834771	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr5:37834771G>A	ENST00000326524.2	-	2	327	c.128C>T	c.(127-129)gCg>gTg	p.A43V	GDNF_ENST00000344622.4_Intron|GDNF_ENST00000515058.1_Intron|GDNF_ENST00000427982.1_Missense_Mutation_p.A60V|GDNF_ENST00000381826.4_Intron	NM_000514.3	NP_000505.1	P39905	GDNF_HUMAN	glial cell derived neurotrophic factor	43					adult locomotory behavior|anti-apoptosis|axon guidance|branching involved in ureteric bud morphogenesis|enteric nervous system development|mRNA stabilization|negative regulation of neuron apoptosis|neural crest cell migration|peristalsis|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of dopamine secretion|positive regulation of monooxygenase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of ureteric bud formation|postganglionic parasympathetic nervous system development|regulation of dopamine uptake|signal transduction|sympathetic nervous system development	extracellular region	growth factor activity|protein homodimerization activity			NS(1)|endometrium(1)|large_intestine(2)|liver(1)|lung(8)|skin(2)	15	all_lung(31;0.00118)					CGCGAAGGGCGCGCGGCGGCG	0.771000													3	16					0	0	1	0	0
PCK2	5106	broad.mit.edu	37	14	24567423	24567423	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr14:24567423G>A	ENST00000216780.4	+	3	555	c.287G>A	c.(286-288)cGc>cAc	p.R96H	PCK2_ENST00000558096.1_5'UTR|NRL_ENST00000561028.1_Intron|PCK2_ENST00000545054.2_5'UTR|PCK2_ENST00000559250.1_Missense_Mutation_p.R108H|PCK2_ENST00000396973.4_Missense_Mutation_p.R96H|PCK2_ENST00000561286.1_5'UTR	NM_004563.2	NP_004554.2	Q16822	PCKGM_HUMAN	phosphoenolpyruvate carboxykinase 2 (mitochondrial)	96					gluconeogenesis	mitochondrial matrix	GTP binding|metal ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			breast(2)|endometrium(2)|kidney(3)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	18				GBM - Glioblastoma multiforme(265;0.0184)		TGGCTGGCCCGCACAGACCCC	0.592000													3	22					0	0	1	0	0
PRKDC	5591	broad.mit.edu	37	8	48690396	48690396	+	Missense_Mutation	SNP	G	G	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr8:48690396G>A	ENST00000314191.2	-	85	11946	c.11890C>T	c.(11890-11892)Cgc>Tgc	p.R3964C	PRKDC_ENST00000523565.1_5'UTR|PRKDC_ENST00000338368.3_Missense_Mutation_p.R3933C	NM_006904.6	NP_008835.5	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic polypeptide	3965	PI3K/PI4K.				cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				ATAAACTGGCGAGTTAGCCGA	0.483000								Non-homologous end-joining					14	73					0	0	1	0	0
LINGO3	645191	broad.mit.edu	37	19	2290209	2290209	+	Missense_Mutation	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr19:2290209C>T	ENST00000585527.1	-	1	1814	c.1567G>A	c.(1567-1569)Gac>Aac	p.D523N	LINGO3_ENST00000404279.1_Missense_Mutation_p.D523N			P0C6S8	LIGO3_HUMAN	leucine rich repeat and Ig domain containing 3	523						integral to membrane				lung(1)|urinary_tract(1)	2						GTGGTGAGGTCGAGCGGCGCG	0.716000													14	11					0	0	1	0	0
ADAM30	11085	broad.mit.edu	37	1	120438648	120438648	+	Silent	SNP	A	A	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr1:120438648A>T	ENST00000369400.1	-	1	470	c.312T>A	c.(310-312)ccT>ccA	p.P104P		NM_021794.3	NP_068566.2	Q9UKF2	ADA30_HUMAN	ADAM metallopeptidase domain 30	104					proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(11)|lung(16)|ovary(2)|skin(2)	38	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;1.55e-06)|Lung NSC(69;1.04e-05)|all_epithelial(167;0.00138)		Lung(183;0.0204)|LUSC - Lung squamous cell carcinoma(189;0.117)		TTGGTATGTAAGGATGATCCT	0.502000													33	35					0	0	1	0	0
SH3PXD2B	285590	broad.mit.edu	37	5	171773245	171773245	+	Silent	SNP	C	C	T			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr5:171773245C>T	ENST00000311601.5	-	12	1253	c.1083G>A	c.(1081-1083)ccG>ccA	p.P361P	SH3PXD2B_ENST00000519643.1_Silent_p.P361P	NM_001017995.2	NP_001017995.1	A1X283	SPD2B_HUMAN	SH3 and PX domains 2B	361					adipose tissue development|bone development|cell communication|cell differentiation|eye development|heart development|podosome assembly	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-5-phosphate binding|SH2 domain binding			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(12)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	36	Renal(175;0.000159)|Lung NSC(126;0.011)|all_lung(126;0.0175)	Medulloblastoma(196;0.0207)|all_neural(177;0.0625)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TGGGCGGCTTCGGCAGGTTGA	0.597000													25	105					0	0	1	0	0
CDC25A	993	broad.mit.edu	37	3	48224431	48224431	+	Missense_Mutation	SNP	C	C	A			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr3:48224431C>A	ENST00000302506.3	-	5	825	c.417G>T	c.(415-417)gaG>gaT	p.E139D	CDC25A_ENST00000351231.3_Missense_Mutation_p.E139D	NM_001789.2	NP_001780.2	P30304	MPIP1_HUMAN	cell division cycle 25A	139					cell cycle checkpoint|cell division|cell proliferation|cellular response to UV|DNA replication|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitosis|regulation of cyclin-dependent protein kinase activity|S phase of mitotic cell cycle	cytosol|nucleoplasm	protein binding|protein tyrosine phosphatase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(9)|prostate(1)|skin(1)	20				BRCA - Breast invasive adenocarcinoma(193;0.000685)|KIRC - Kidney renal clear cell carcinoma(197;0.00596)|Kidney(197;0.00684)		TTTCCTTGTTCTCATCTGGGT	0.483000													29	61					3.73148e-12	4.13855e-12	1	1	0
FAM208A	23272	broad.mit.edu	37	3	56662575	56662575	+	Missense_Mutation	SNP	A	A	G			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr3:56662575A>G	ENST00000431842.2	-	12	3428	c.2504T>C	c.(2503-2505)tTa>tCa	p.L835S	FAM208A_ENST00000355628.5_Missense_Mutation_p.L1211S|FAM208A_ENST00000493960.2_Missense_Mutation_p.L1272S	NM_015224.3	NP_056039.2	Q9UK61	CC063_HUMAN	family with sequence similarity 208, member A	1272										NS(1)|breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(11)|prostate(3)|skin(1)	32						TAGTTTATCTAATTTTGATCT	0.274000													16	41					0	0	1	0	0
ZDBF2	57683	broad.mit.edu	37	2	207169788	207169789	+	Frame_Shift_Ins	INS	-	-	C			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr2:207169788_207169789insC	ENST00000374423.3	+	5	922_923	c.536_537insC	c.(535-540)cgccccfs	p.RP179fs		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	179							nucleic acid binding|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						AACTTGGTACGCCCCCCAGTGA	0.426													18	24	---	---	---	---					
RHBDD1	84236	broad.mit.edu	37	2	227779059	227779059	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr2:227779059delG	ENST00000392062.2	+	8	1372	c.848delG	c.(847-849)tggfs	p.W283fs	RHBDD1_ENST00000409053.1_Frame_Shift_Del_p.W117fs|RHBDD1_ENST00000493526.1_3'UTR|RHBDD1_ENST00000341329.3_Frame_Shift_Del_p.W283fs	NM_001167608.1	NP_001161080.1	Q8TEB9	RHBD1_HUMAN	rhomboid domain containing 1	283						integral to membrane	serine-type endopeptidase activity			breast(1)|large_intestine(5)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	19		Renal(207;0.023)|all_lung(227;0.13)|Esophageal squamous(248;0.23)|all_hematologic(139;0.248)		Epithelial(121;1.47e-11)|all cancers(144;1.52e-08)|Lung(261;0.0128)|LUSC - Lung squamous cell carcinoma(224;0.0175)		GCCAGCCTCTGGGACCGAGGT	0.443													21	24	---	---	---	---					
FBXO38	81545	broad.mit.edu	37	5	147781970	147781974	+	Frame_Shift_Del	DEL	TCATA	TCATA	-			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr5:147781970_147781974delTCATA	ENST00000340253.5	+	5	654_658	c.486_490delTCATA	c.(484-492)gttcatattfs	p.HI163fs	FBXO38_ENST00000296701.6_Frame_Shift_Del_p.HI163fs|FBXO38_ENST00000509699.2_3'UTR|FBXO38_ENST00000513826.1_Frame_Shift_Del_p.HI163fs|FBXO38_ENST00000394370.3_Frame_Shift_Del_p.HI163fs			Q6PIJ6	FBX38_HUMAN	F-box protein 38	163						cytoplasm|nucleus			ATG4C/FBXO38(2)	NS(1)|breast(2)|endometrium(7)|kidney(5)|large_intestine(9)|lung(15)|ovary(5)|prostate(2)|skin(2)|stomach(2)|urinary_tract(1)	51			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCCCCATGTTCATATTTTGGGGAA	0.346													25	67	---	---	---	---					
MLLT3	4300	broad.mit.edu	37	9	20414278	20414280	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr9:20414278_20414280delCTG	ENST00000380338.4	-	5	850_852	c.564_566delCAG	c.(562-567)agcagt>agt	p.188_189SS>S	MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000429426.2_In_Frame_Del_p.185_186SS>S	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	188	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S188S(1)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		ACTGGTActactgctgctgctgc	0.507			T	MLL	ALL								7	124	---	---	---	---					
SIDT2	51092	broad.mit.edu	37	11	117064644	117064645	+	In_Frame_Ins	INS	-	-	TCT			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr11:117064644_117064645insTCT	ENST00000324225.4	+	24	2818_2819	c.2287_2288insTCT	c.(2287-2289)ctc>cTCTtc	p.767_768insF	SIDT2_ENST00000431081.2_In_Frame_Ins_p.764_765insF|SIDT2_ENST00000532062.1_In_Frame_Ins_p.59_60insF	NM_001040455.1	NP_001035545.1	Q8NBJ9	SIDT2_HUMAN	SID1 transmembrane family, member 2	767	Poly-Phe.					integral to membrane|lysosomal membrane				NS(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(9)|lung(11)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	36	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.69e-05)|Epithelial(105;0.000219)|all cancers(92;0.00144)		GGGCTTCGCGCTCTTCTTCTTC	0.604													20	26	---	---	---	---					
RP11-1166P10.6	0	broad.mit.edu	37	16	32077916	32077917	+	RNA	INS	-	-	TTTT	rs139112308	by1000genomes	TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr16:32077916_32077917insTTTT	ENST00000566806.1	-	0	499																											ATGGAAAACGGTTATTTTTTTG	0.421													6	4	---	---	---	---					
ZC3H18	124245	broad.mit.edu	37	16	88666210	88666211	+	Frame_Shift_Ins	INS	-	-	GC			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr16:88666210_88666211insGC	ENST00000301011.5	+	6	1142_1143	c.942_943insGC	c.(943-945)gcafs	p.A315fs	ZC3H18_ENST00000452588.2_Frame_Shift_Ins_p.A339fs	NM_144604.3	NP_653205.3	Q86VM9	ZCH18_HUMAN	zinc finger CCCH-type containing 18	315						nucleus	nucleic acid binding|zinc ion binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(9)|lung(16)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	42				BRCA - Breast invasive adenocarcinoma(80;0.0542)		TTTTAAAAAAAGCAACTATTCG	0.431													38	121	---	---	---	---