Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
DMXL1	1657	broad.mit.edu	37	5	118485427	118485427	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:118485427C>A	ENST00000311085.8	+	18	3985	c.3905C>A	c.(3904-3906)cCt>cAt	p.P1302H	DMXL1_ENST00000539542.1_Missense_Mutation_p.P1302H	NM_005509.4	NP_005500.4	Q9Y485	DMXL1_HUMAN	Dmx-like 1	1302										breast(3)|central_nervous_system(1)|endometrium(14)|kidney(4)|large_intestine(20)|liver(6)|lung(28)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)	86		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		GCATTCGATCCTTCAGTGGAT	0.438000													51	20					2.76378e-25	3.52335e-25	1	1	0
PSMB1	5689	broad.mit.edu	37	6	170862291	170862291	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:170862291C>G	ENST00000262193.6	-	1	138	c.40G>C	c.(40-42)Gac>Cac	p.D14H		NM_002793.3	NP_002784.1	P20618	PSB1_HUMAN	proteasome (prosome, macropain) subunit, beta type, 1	14					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cell junction|cytoplasm|nucleus|proteasome core complex	protein binding|threonine-type endopeptidase activity			endometrium(2)|large_intestine(1)|lung(1)|ovary(1)	5		Breast(66;5.08e-05)|Ovarian(120;0.0563)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;7.5e-23)|BRCA - Breast invasive adenocarcinoma(81;4.88e-06)|GBM - Glioblastoma multiforme(31;0.00643)	Bortezomib(DB00188)	ATCCCCAAGTCTCTGCCAGGA	0.597000													7	19					0	0	1	0	0
KLK15	55554	broad.mit.edu	37	19	51329189	51329189	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:51329189G>A	ENST00000326856.4	-	6	760	c.631C>T	c.(631-633)Ccc>Tcc	p.P211S	KLK15_ENST00000301421.2_3'UTR|KLK15_ENST00000598239.1_Missense_Mutation_p.P212S|KLK15_ENST00000416184.1_Missense_Mutation_p.P127S|KLK15_ENST00000596931.1_3'UTR	NM_001277081.1	NP_001264010.1	Q9H2R5	KLK15_HUMAN	kallikrein-related peptidase 15	212	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			breast(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(12)|skin(2)|upper_aerodigestive_tract(1)	24		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.0143)		CAGACCAGGGGTCCCCCAGAG	0.552000													33	19					0	0	1	0	0
PLXND1	23129	broad.mit.edu	37	3	129284333	129284333	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:129284333C>A	ENST00000393239.1	-	25	4549	c.4371G>T	c.(4369-4371)gaG>gaT	p.E1457D	PLXND1_ENST00000324093.4_Missense_Mutation_p.E1457D			Q9Y4D7	PLXD1_HUMAN	plexin D1	1457					axon guidance	integral to membrane|intracellular|plasma membrane			PLXND1/TMCC1(4)	NS(1)|breast(1)|endometrium(4)|kidney(5)|large_intestine(17)|lung(28)|prostate(10)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	72						TGGTGTAGTACTCCAGCTTGC	0.632000													67	54					2.69673e-31	3.60435e-31	1	1	0
PCDHGA6	56109	broad.mit.edu	37	5	140755960	140755960	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:140755960C>A	ENST00000517434.1	+	1	2310	c.2310C>A	c.(2308-2310)ttC>ttA	p.F770L	PCDHGA1_ENST00000517417.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA5_ENST00000518069.1_Intron	NM_018919.2|NM_032086.1	NP_061742.1|NP_114475.1														breast(1)|large_intestine(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATCTGATTTTCCCCCAGCCCA	0.517000													80	30					3.89792e-41	5.39262e-41	1	1	0
TTN	7273	broad.mit.edu	37	2	179403929	179403929	+	Silent	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:179403929C>T	ENST00000589042.1	-	353	98957	c.98733G>A	c.(98731-98733)aaG>aaA	p.K32911K	TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000342175.6_Silent_p.K24038K|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000342992.6_Silent_p.K30343K|TTN-AS1_ENST00000592600.1_RNA|TTN_ENST00000460472.2_Silent_p.K23846K|TTN_ENST00000591111.1_Silent_p.K31270K|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN_ENST00000359218.5_Silent_p.K23971K|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000589434.1_RNA|TTN-AS1_ENST00000590040.1_RNA|TTN-AS1_ENST00000586707.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	31270							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TAACAGAACTCTTGGTTACAT	0.458000													11	35					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114276414	114276414	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:114276414C>A	ENST00000357077.4	+	38	6693	c.6640C>A	c.(6640-6642)Ccg>Acg	p.P2214T	ANK2_ENST00000506722.1_Intron|ANK2_ENST00000264366.6_Missense_Mutation_p.P2181T|ANK2_ENST00000394537.3_Intron|ANK2_ENST00000510275.2_Intron|ANK2_ENST00000509550.1_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	2181					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		AGCCGGCTCTCCGTGTGGCAG	0.517000													50	74					1.07234e-20	1.31834e-20	1	1	0
KIAA0930	23313	broad.mit.edu	37	22	45601541	45601541	+	Silent	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr22:45601541C>T	ENST00000336156.5	-	4	449	c.384G>A	c.(382-384)ggG>ggA	p.G128G	KIAA0930_ENST00000251993.7_Silent_p.G133G|KIAA0930_ENST00000391627.2_Silent_p.G94G|KIAA0930_ENST00000443310.3_Silent_p.G110G	NM_001009880.1	NP_001009880.1	Q6ICG6	K0930_HUMAN	KIAA0930								protein binding			endometrium(1)|kidney(4)|large_intestine(2)|lung(7)|urinary_tract(1)	15						TGTGAATGTCCCCGCCGTCAG	0.612000													29	43					0	0	1	0	0
RNF183	138065	broad.mit.edu	37	9	116060181	116060181	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:116060181C>A	ENST00000478815.1	-	1	1864	c.284G>T	c.(283-285)gGc>gTc	p.G95V	RNF183_ENST00000416588.2_Missense_Mutation_p.G95V|RNF183_ENST00000441031.3_Missense_Mutation_p.G95V|RNF183_ENST00000297894.5_Missense_Mutation_p.G95V			Q96D59	RN183_HUMAN	ring finger protein 183	95						integral to membrane	zinc ion binding			lung(1)|prostate(1)|skin(1)	3						CAGCTGATGGCCTTCCAGGAT	0.657000													52	40					3.19069e-20	3.87942e-20	1	1	0
PAH	5053	broad.mit.edu	37	12	103288653	103288653	+	Missense_Mutation	SNP	C	C	T	rs62508695		TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:103288653C>T	ENST00000553106.1	-	3	684	c.212G>A	c.(211-213)cGt>cAt	p.R71H	PAH_ENST00000307000.2_Missense_Mutation_p.R66H|PAH_ENST00000551988.1_5'UTR	NM_000277.1	NP_000268.1	P00439	PH4H_HUMAN	phenylalanine hydroxylase	71	ACT.				catecholamine biosynthetic process|L-phenylalanine catabolic process|neurotransmitter biosynthetic process	cytosol	phenylalanine 4-monooxygenase activity			endometrium(1)|kidney(3)|large_intestine(5)|lung(10)|ovary(5)|skin(2)|urinary_tract(1)	27					Epinephrine(DB00668)|L-Phenylalanine(DB00120)|Levodopa(DB01235)|Norepinephrine(DB00368)|Tetrahydrobiopterin(DB00360)	TTTCTTTAAACGAGAAGGTCT	0.443000													23	89					0	0	1	0	0
PSD4	23550	broad.mit.edu	37	2	113941042	113941042	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:113941042G>C	ENST00000441564.3	+	2	1178	c.1009G>C	c.(1009-1011)Gcc>Ccc	p.A337P	PSD4_ENST00000245796.6_Missense_Mutation_p.A337P			Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4						regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(13)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						CTCAGTGGCTGCCGCTGAGGG	0.617000													29	32					0	0	1	0	0
KIAA0368	23392	broad.mit.edu	37	9	114204677	114204677	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:114204677C>A	ENST00000259335.4	-	6	831	c.832G>T	c.(832-834)Ggc>Tgc	p.G278C	KIAA0368_ENST00000338205.5_Missense_Mutation_p.G100C	NM_001080398.1	NP_001073867.1			KIAA0368											NS(2)|breast(3)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(23)|prostate(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	65						CGAGGATAGCCCATTTTAACA	0.378000													7	14					0.00198382	0.00200195	1	1	0
IMPG1	3617	broad.mit.edu	37	6	76751757	76751757	+	Missense_Mutation	SNP	A	A	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:76751757A>G	ENST00000369950.3	-	2	343	c.154T>C	c.(154-156)Tac>Cac	p.Y52H	IMPG1_ENST00000369963.3_Intron	NM_001282368.1|NM_001563.2	NP_001269297.1|NP_001554.2	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	52					visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			breast(5)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(8)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	63		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				GACATTTTGTACATTTTTTCA	0.358000													59	55					0	0	1	0	0
SLC6A3	6531	broad.mit.edu	37	5	1441523	1441523	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:1441523G>T	ENST00000270349.9	-	3	496	c.369C>A	c.(367-369)ttC>ttA	p.F123L	SLC6A3_ENST00000453492.2_Missense_Mutation_p.F123L	NM_001044.4	NP_001035.1	Q01959	SC6A3_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 3	123					cell death|neurotransmitter biosynthetic process	axon|cytoplasm|integral to plasma membrane|neuronal cell body				breast(2)|endometrium(4)|kidney(1)|large_intestine(3)|lung(19)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	38			OV - Ovarian serous cystadenocarcinoma(19;0.00928)|all cancers(22;0.0262)		Amphetamine(DB00182)|Benztropine(DB00245)|Bupropion(DB01156)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dextroamphetamine(DB01576)|Diethylpropion(DB00937)|Duloxetine(DB00476)|Fencamfamine(DB01463)|Mazindol(DB00579)|Methylphenidate(DB00422)|Modafinil(DB00745)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Procaine(DB00721)	CTTCCCTGTTGAACTGGCCGA	0.587000													33	23					6.50621e-10	7.05585e-10	1	1	0
UNC13C	440279	broad.mit.edu	37	15	54803976	54803976	+	Missense_Mutation	SNP	A	A	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr15:54803976A>G	ENST00000545554.1	+	23	5405	c.5405A>G	c.(5404-5406)cAa>cGa	p.Q1802R	UNC13C_ENST00000537900.1_Missense_Mutation_p.Q1800R|UNC13C_ENST00000260323.11_Missense_Mutation_p.Q1802R			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	1802					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		AACAATATTCAACAATTGCGG	0.313000													11	5					0	0	1	0	0
TUBA3D	113457	broad.mit.edu	37	2	132235813	132235813	+	Missense_Mutation	SNP	A	A	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:132235813A>G	ENST00000321253.6	+	2	187	c.80A>G	c.(79-81)gAa>gGa	p.E27G		NM_080386.3	NP_525125.2	Q13748	TBA3C_HUMAN	tubulin, alpha 3d	27					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(18)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	32				BRCA - Breast invasive adenocarcinoma(221;0.13)		TACTGCCTTGAACATGGAATT	0.532000													53	97					0	0	1	0	0
ZMYND8	23613	broad.mit.edu	37	20	45927519	45927519	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:45927519C>A	ENST00000311275.7	-	4	600	c.347G>T	c.(346-348)aGa>aTa	p.R116I	ZMYND8_ENST00000262975.4_Missense_Mutation_p.R116I|ZMYND8_ENST00000372023.3_Missense_Mutation_p.R111I|ZMYND8_ENST00000540497.1_Missense_Mutation_p.R111I|ZMYND8_ENST00000468376.2_5'UTR|ZMYND8_ENST00000446994.2_Missense_Mutation_p.R91I|ZMYND8_ENST00000396281.4_Missense_Mutation_p.R116I|ZMYND8_ENST00000536340.1_Missense_Mutation_p.R143I|ZMYND8_ENST00000471951.2_Missense_Mutation_p.R136I|ZMYND8_ENST00000458360.2_Missense_Mutation_p.R111I|ZMYND8_ENST00000352431.2_Missense_Mutation_p.R136I|ZMYND8_ENST00000355972.4_Missense_Mutation_p.R116I|ZMYND8_ENST00000360911.3_Missense_Mutation_p.R111I|ZMYND8_ENST00000461685.1_Missense_Mutation_p.R136I	NM_001281772.1|NM_001281778.1|NM_001281783.1	NP_001268701.1|NP_001268707.1|NP_001268712.1	Q9ULU4	PKCB1_HUMAN	zinc finger, MYND-type containing 8	116							protein binding|zinc ion binding			NS(1)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(22)|ovary(1)|prostate(3)|skin(2)|urinary_tract(8)	62			Epithelial(1;0.0289)|all cancers(1;0.0962)|OV - Ovarian serous cystadenocarcinoma(1;0.154)			CGATGTCAGTCTCAGACACTT	0.502000													36	24					9.17885e-22	1.13859e-21	1	1	0
BACH2	60468	broad.mit.edu	37	6	90661238	90661238	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:90661238G>T	ENST00000257749.4	-	7	1294	c.587C>A	c.(586-588)gCc>gAc	p.A196D	BACH2_ENST00000537989.1_Missense_Mutation_p.A196D|BACH2_ENST00000343122.3_Missense_Mutation_p.A196D|RP3-512E2.2_ENST00000445838.1_RNA|RP3-512E2.2_ENST00000413986.1_RNA	NM_021813.2	NP_068585.1	Q9BYV9	BACH2_HUMAN	BTB and CNC homology 1, basic leucine zipper transcription factor 2	196						nucleus	protein dimerization activity|sequence-specific DNA binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(18)|ovary(5)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	45		all_cancers(76;7.37e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.0063)		BRCA - Breast invasive adenocarcinoma(108;0.0799)		TACGGGGATGGCGGCGGCCTC	0.602000													53	57					1.86277e-20	2.26987e-20	1	1	0
WDR1	9948	broad.mit.edu	37	4	10084738	10084738	+	Silent	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:10084738C>A	ENST00000382452.2	-	10	1386	c.1104G>T	c.(1102-1104)gtG>gtT	p.V368V	WDR1_ENST00000502702.1_Silent_p.V228V|WDR1_ENST00000382451.2_Silent_p.V228V|WDR1_ENST00000499869.2_Silent_p.V368V|WDR1_ENST00000515743.1_5'UTR	NM_017491.3	NP_059830.1	O75083	WDR1_HUMAN	WD repeat domain 1	368					platelet activation|platelet degranulation|sensory perception of sound	cytoskeleton|cytosol|extracellular region	actin binding			endometrium(3)|lung(5)|ovary(2)|pancreas(1)|urinary_tract(1)	12				STAD - Stomach adenocarcinoma(129;0.000703)|Colorectal(103;0.0057)|LUSC - Lung squamous cell carcinoma(721;0.0232)		TCATCCTGGACACCTGGTTCG	0.602000													18	26					5.03518e-11	5.54775e-11	1	1	0
SMTN	6525	broad.mit.edu	37	22	31491427	31491427	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr22:31491427G>A	ENST00000333137.7	+	12	1989	c.1771G>A	c.(1771-1773)Gtc>Atc	p.V591I	SMTN_ENST00000347557.2_Missense_Mutation_p.V591I|SMTN_ENST00000358743.1_Missense_Mutation_p.V591I|SMTN_ENST00000404574.1_Missense_Mutation_p.V190I	NM_001207018.1|NM_134269.2	NP_001193947.1|NP_599031.1	P53814	SMTN_HUMAN	smoothelin	591					muscle organ development|smooth muscle contraction	actin cytoskeleton|cytoplasm	actin binding|structural constituent of muscle			breast(2)|endometrium(2)|large_intestine(5)|lung(9)|ovary(3)|pancreas(1)|prostate(3)	25						GGATGAAGGAGTCTTGGACAA	0.582000													24	26					0	0	1	0	0
CEP104	9731	broad.mit.edu	37	1	3742336	3742336	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:3742336C>A	ENST00000378230.3	-	18	2674	c.2350G>T	c.(2350-2352)Gac>Tac	p.D784Y		NM_014704.3	NP_055519.1	O60308	CE104_HUMAN	centrosomal protein 104kDa	784						centriole	binding			breast(2)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(14)|lung(8)|prostate(1)|skin(3)	39						TTGCAGTGGTCACATCTTGTC	0.507000													45	32					1.61004e-24	2.02909e-24	1	1	0
LRTM2	654429	broad.mit.edu	37	12	1940231	1940231	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:1940231G>A	ENST00000543818.1	+	4	1040	c.198G>A	c.(196-198)gtG>gtA	p.V66V	CACNA2D4_ENST00000585732.1_Intron|LRTM2_ENST00000299194.1_Silent_p.V66V|CACNA2D4_ENST00000586184.1_Intron|CACNA2D4_ENST00000585708.1_Intron|CACNA2D4_ENST00000587995.1_Intron|LRTM2_ENST00000543730.1_Intron|CACNA2D4_ENST00000382722.5_Intron|LRTM2_ENST00000535041.1_Silent_p.V66V|CACNA2D4_ENST00000588077.1_Intron	NM_001039029.2|NM_001163925.1|NM_001163926.1	NP_001034118.1|NP_001157397.1|NP_001157398.1	Q8N967	LRTM2_HUMAN	leucine-rich repeats and transmembrane domains 2	66	LRRNT.					integral to membrane				NS(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	20	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.000834)			CCCCAGACGTGCCCGCAGCCA	0.642000													94	79					0	0	1	0	0
CNNM3	26505	broad.mit.edu	37	2	97482025	97482025	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:97482025C>A	ENST00000305510.3	+	1	39	c.11C>A	c.(10-12)gCg>gAg	p.A4E	CNNM3_ENST00000377060.3_Missense_Mutation_p.A4E	NM_017623.4	NP_060093.3	Q8NE01	CNNM3_HUMAN	cyclin M3	4					ion transport	integral to membrane|plasma membrane	protein binding			NS(1)|kidney(2)|large_intestine(2)|lung(3)|ovary(2)|skin(1)|urinary_tract(2)	13						ATGGCGGCGGCGGTAGCTGCG	0.761000													5	4					0.248553	0.248553	1	1	0
SHD	56961	broad.mit.edu	37	19	4280064	4280064	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:4280064G>A	ENST00000543264.2	+	1	1467	c.4G>A	c.(4-6)Gcc>Acc	p.A2T	SHD_ENST00000599689.1_Missense_Mutation_p.A2T	NM_020209.3	NP_064594.3	Q96IW2	SHD_HUMAN	Src homology 2 domain containing transforming protein D	2										breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|stomach(1)	14				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0337)|STAD - Stomach adenocarcinoma(1328;0.18)		CGCCCAAATGGCCAAGTGGCT	0.682000													8	1					0	0	1	0	0
TBC1D2B	23102	broad.mit.edu	37	15	78290635	78290635	+	Missense_Mutation	SNP	C	C	T	rs117285325	by1000genomes	TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr15:78290635C>T	ENST00000409931.3	-	13	2778	c.2707G>A	c.(2707-2709)Gac>Aac	p.D903N	TBC1D2B_ENST00000492078.1_5'UTR|TBC1D2B_ENST00000300584.3_Missense_Mutation_p.R920Q			Q9UPU7	TBD2B_HUMAN	TBC1 domain family, member 2B	0						intracellular	protein binding|Rab GTPase activator activity	p.D903N(3)|p.R920Q(1)		breast(3)|cervix(2)|endometrium(4)|kidney(1)|large_intestine(7)|lung(2)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	26						GTAGGCGCGTCGGTTCCGGAT	0.617000													3	20					0	0	1	0	0
AMER3	205147	broad.mit.edu	37	2	131521341	131521341	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:131521341C>G	ENST00000423981.1	+	2	1806	c.1696C>G	c.(1696-1698)Cag>Gag	p.Q566E	AMER3_ENST00000321420.4_Missense_Mutation_p.Q566E	NM_001105193.1|NM_001105194.1|NM_001105195.1|NM_152698.2	NP_001098663.1|NP_001098664.1|NP_001098665.1|NP_689911.2			APC membrane recruitment protein 3																		ACCCAGCAGGCAGGAGCTGTG	0.692000													19	26					0	0	1	0	0
ZNF774	342132	broad.mit.edu	37	15	90897897	90897897	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr15:90897897G>C	ENST00000354377.3	+	2	191	c.5G>C	c.(4-6)tGg>tCg	p.W2S	ZNF774_ENST00000558115.1_Intron|ZNF774_ENST00000379090.5_Missense_Mutation_p.W2S	NM_001004309.2	NP_001004309.2	Q6NX45	ZN774_HUMAN	zinc finger protein 774	2	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|cervix(1)|endometrium(2)|large_intestine(4)|lung(4)|prostate(1)|stomach(1)	14	Melanoma(11;0.00551)|Lung NSC(78;0.0158)|all_lung(78;0.0331)		BRCA - Breast invasive adenocarcinoma(143;0.0224)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			TTGATAATGTGGCTGGGGACT	0.483000													10	11					0	0	1	0	0
XIST	7503	broad.mit.edu	37	X	73064405	73064405	+	RNA	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chrX:73064405C>T	ENST00000429829.1	-	0	8183					NR_001564.2																						CAATTGTGCACCTTGATTGTC	0.453000													28	6					0	0	1	0	0
BIN1	274	broad.mit.edu	37	2	127821519	127821519	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:127821519G>A	ENST00000316724.5	-	8	1099	c.688C>T	c.(688-690)Ctg>Ttg	p.L230L	BIN1_ENST00000393040.3_Silent_p.L199L|BIN1_ENST00000348750.4_Silent_p.L199L|BIN1_ENST00000393041.3_Silent_p.L199L|BIN1_ENST00000357970.3_Silent_p.L230L|BIN1_ENST00000409400.1_Silent_p.L199L|BIN1_ENST00000346226.3_Silent_p.L199L|BIN1_ENST00000351659.3_Silent_p.L230L|BIN1_ENST00000376113.2_Silent_p.L199L|BIN1_ENST00000352848.3_Silent_p.L199L|BIN1_ENST00000466111.1_5'UTR|BIN1_ENST00000259238.4_Silent_p.L199L	NM_139343.2	NP_647593.1	O00499	BIN1_HUMAN	bridging integrator 1	230	BAR.				cell proliferation|endocytosis|interspecies interaction between organisms|multicellular organismal development	actin cytoskeleton|nucleus				NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(3)|lung(6)|ovary(3)|prostate(3)|skin(3)	24	Colorectal(110;0.0831)			BRCA - Breast invasive adenocarcinoma(221;0.073)		CTGTTCCACAGGGACGGCAGC	0.652000													51	48					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	4153858	4153858	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:4153858G>T	ENST00000404826.2	+	25	3914	c.3775G>T	c.(3775-3777)Ggg>Tgg	p.G1259W	SDK1_ENST00000389531.3_Missense_Mutation_p.G1259W	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	1259	Fibronectin type-III 6.				cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		CAACGCCGTCGGGGCTGGGCC	0.642000													26	21					2.44723e-14	2.81432e-14	1	1	0
KRT83	3889	broad.mit.edu	37	12	52709714	52709714	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:52709714C>A	ENST00000293670.3	-	7	1287	c.1225G>T	c.(1225-1227)Gcc>Tcc	p.A409S	AC121757.1_ENST00000594763.1_Intron	NM_002282.3	NP_002273.3	P78385	KRT83_HUMAN	keratin 83	409	Coil 2.|Rod.				epidermis development	keratin filament	structural molecule activity			NS(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(9)|prostate(1)|skin(4)|stomach(7)|upper_aerodigestive_tract(1)	32	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)		CTGTAGGTGGCGATCTCGATA	0.597000													62	68					1.98135e-44	2.75493e-44	1	1	0
SNX14	57231	broad.mit.edu	37	6	86227735	86227735	+	Silent	SNP	T	T	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:86227735T>C	ENST00000314673.3	-	22	2315	c.2139A>G	c.(2137-2139)ctA>ctG	p.L713L	SNX14_ENST00000369627.2_Silent_p.L704L|SNX14_ENST00000508980.1_5'UTR|SNX14_ENST00000346348.3_Silent_p.L660L|SNX14_ENST00000513865.1_Silent_p.L432L|SNX14_ENST00000505648.1_Silent_p.L661L	NM_153816.3	NP_722523.1	Q9Y5W7	SNX14_HUMAN	sorting nexin 14	713					cell communication|protein transport	integral to membrane	phosphatidylinositol binding|signal transducer activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(11)|skin(1)	22		all_cancers(76;4.83e-07)|Acute lymphoblastic leukemia(125;3.3e-08)|Prostate(29;2.55e-07)|all_hematologic(105;3.66e-05)|all_epithelial(107;0.000695)|Lung NSC(302;0.197)|all_lung(197;0.24)		BRCA - Breast invasive adenocarcinoma(108;0.0423)		CCTCTTTCATTAGTTTTCCAG	0.254000													45	55					0	0	1	0	0
SLC12A7	10723	broad.mit.edu	37	5	1064299	1064299	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:1064299G>T	ENST00000264930.5	-	19	2549	c.2506C>A	c.(2506-2508)Caa>Aaa	p.Q836K		NM_006598.2	NP_006589.2	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 7	836					potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	32	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	TCCTGGTTTTGCGGAAACGAG	0.672000													15	29					2.23348e-06	2.31745e-06	1	1	0
ZNF668	79759	broad.mit.edu	37	16	31073488	31073488	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:31073488C>T	ENST00000538906.1	-	3	1545	c.761G>A	c.(760-762)tGc>tAc	p.C254Y	ZNF668_ENST00000539836.3_Missense_Mutation_p.C277Y|ZNF668_ENST00000426488.2_Missense_Mutation_p.C277Y|ZNF668_ENST00000535577.1_Missense_Mutation_p.C254Y|ZNF668_ENST00000394983.2_Missense_Mutation_p.C254Y|ZNF668_ENST00000300849.4_Missense_Mutation_p.C254Y	NM_001172668.1	NP_001166139	Q96K58	ZN668_HUMAN	zinc finger protein 668	254					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(6)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	27						GCAGGCCGGGCAGCGGTAGGG	0.697000													35	39					0	0	1	0	0
FLRT3	23767	broad.mit.edu	37	20	14307612	14307612	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:14307612G>A	ENST00000378053.3	-	2	797	c.541C>T	c.(541-543)Cgc>Tgc	p.R181C	MACROD2_ENST00000217246.4_Intron|FLRT3_ENST00000341420.4_Missense_Mutation_p.R181C|MACROD2_ENST00000310348.4_Intron	NM_013281.3	NP_037413.1	Q9NZU0	FLRT3_HUMAN	fibronectin leucine rich transmembrane protein 3	181					cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			breast(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Colorectal(1;0.0464)	COAD - Colon adenocarcinoma(2;0.129)	Colorectal(1;0.0393)		TCATCCAAGCGTAGTTCTTCT	0.458000													23	145					0	0	1	0	0
SLC13A4	26266	broad.mit.edu	37	7	135376027	135376027	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:135376027C>G	ENST00000354042.4	-	13	2054	c.1365G>C	c.(1363-1365)tgG>tgC	p.W455C	C7orf73_ENST00000422968.1_Intron	NM_012450.2	NP_036582.2	Q9UKG4	S13A4_HUMAN	solute carrier family 13 (sodium/sulfate symporter), member 4	455						integral to plasma membrane	sodium:sulfate symporter activity			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(6)|lung(7)|skin(1)|upper_aerodigestive_tract(2)	24						GGAAGTCCTTCCACGTGATGA	0.498000													34	46					0	0	1	0	0
GEN1	348654	broad.mit.edu	37	2	17962140	17962140	+	Missense_Mutation	SNP	A	A	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:17962140A>C	ENST00000381254.2	+	14	1875	c.1661A>C	c.(1660-1662)cAg>cCg	p.Q554P	GEN1_ENST00000317402.7_Missense_Mutation_p.Q554P|SMC6_ENST00000402989.1_Intron	NM_001130009.1	NP_001123481.1	Q17RS7	GEN_HUMAN	GEN1 Holliday junction 5' flap endonuclease	554					DNA repair	nucleus	DNA binding|endonuclease activity|metal ion binding			breast(6)|central_nervous_system(1)|kidney(1)|large_intestine(3)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	16	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					TTGGCTATACAGCAAATTAAA	0.363000								Homologous recombination					33	2					0	0	1	0	0
BARHL2	343472	broad.mit.edu	37	1	91178154	91178154	+	Silent	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:91178154C>A	ENST00000370445.4	-	3	920	c.879G>T	c.(877-879)gtG>gtT	p.V293V		NM_020063.1	NP_064447.1	Q9NY43	BARH2_HUMAN	BarH-like homeobox 2	293						nucleus	sequence-specific DNA binding			cervix(2)|endometrium(1)|kidney(3)|large_intestine(5)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	24		all_lung(203;0.0263)|Lung SC(238;0.128)		all cancers(265;0.000897)|Epithelial(280;0.00516)|OV - Ovarian serous cystadenocarcinoma(397;0.211)		ACTCCAGGCCCACCGCTGTCT	0.617000													17	19					9.16793e-09	9.76969e-09	1	1	0
ZNF653	115950	broad.mit.edu	37	19	11609127	11609127	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:11609127C>T	ENST00000585656.1	-	2	238	c.239G>A	c.(238-240)aGc>aAc	p.S80N	ZNF653_ENST00000293771.5_Silent_p.K109K|ZNF653_ENST00000593191.1_5'UTR																							TCCGCTTTGGCTTTTTGGGGA	0.597000													138	514					0	0	1	0	0
CTNND2	1501	broad.mit.edu	37	5	11199772	11199772	+	Splice_Site	SNP	A	A	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:11199772A>C	ENST00000304623.8	-	11	1952	c.1763T>G	c.(1762-1764)aTa>aGa	p.I588R	CTNND2_ENST00000458100.2_Splice_Site_p.I155R|CTNND2_ENST00000359640.2_Splice_Site_p.I588R|CTNND2_ENST00000511377.1_Splice_Site_p.I497R|CTNND2_ENST00000503622.1_Splice_Site_p.I251R|CTNND2_ENST00000495388.2_5'UTR	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	588					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						TTGTCTCCTTATCTGAAAGAG	0.448000													20	30					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179593726	179593726	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:179593726C>A	ENST00000589042.1	-	65	19263	c.19039G>T	c.(19039-19041)Gcc>Tcc	p.A6347S	TTN_ENST00000342175.6_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.A5103S|TTN_ENST00000460472.2_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.A6030S|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	6030	Ig-like 44.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGAAGTGTGGCCACACTGTCC	0.413000													17	15					1.02788e-11	1.15324e-11	1	1	0
PKNOX2	63876	broad.mit.edu	37	11	125221258	125221258	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:125221258C>A	ENST00000542175.1	+	4	280	c.5C>A	c.(4-6)tCc>tAc	p.S2Y	PKNOX2_ENST00000298282.9_Silent_p.V19V|PKNOX2_ENST00000530517.1_Intron			Q96KN3	PKNX2_HUMAN	PBX/knotted 1 homeobox 2	0						nucleus	sequence-specific DNA binding transcription factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(14)|ovary(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	29		Breast(109;0.00234)|all_lung(97;0.0191)|Lung NSC(97;0.0196)|Medulloblastoma(222;0.0447)|all_neural(223;0.116)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.117)		CGCAGAATGTCCCGCCCCCAC	0.657000													11	14					1.08611e-07	1.14414e-07	1	1	0
ZDBF2	57683	broad.mit.edu	37	2	207170202	207170202	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:207170202C>T	ENST00000374423.3	+	5	1336	c.950C>T	c.(949-951)tCt>tTt	p.S317F		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	317							nucleic acid binding|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						GACATGCCTTCTAATAAAGGA	0.368000													8	15					0	0	1	0	0
VAV1	7409	broad.mit.edu	37	19	6828657	6828657	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:6828657G>T	ENST00000304076.2	+	12	1211	c.1117G>T	c.(1117-1119)Gtc>Ttc	p.V373F	VAV1_ENST00000596764.1_Missense_Mutation_p.V341F|VAV1_ENST00000539284.1_Missense_Mutation_p.V276F|VAV1_ENST00000599806.1_Missense_Mutation_p.V318F|VAV1_ENST00000602142.1_Missense_Mutation_p.V373F	NM_001258206.1	NP_001245135.1	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	373	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(16)|lung(18)|ovary(5)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	62						CGTGAACGAGGTCAAGCGAGA	0.632000													33	520					1.36615e-20	1.67209e-20	1	1	0
HUNK	30811	broad.mit.edu	37	21	33297057	33297057	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr21:33297057C>T	ENST00000270112.2	+	2	899	c.539C>T	c.(538-540)gCc>gTc	p.A180V		NM_014586.1	NP_055401.1	P57058	HUNK_HUMAN	hormonally up-regulated Neu-associated kinase	180	Protein kinase.				multicellular organismal development|signal transduction		ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(15)|ovary(1)|skin(2)|stomach(1)	30						CTGCACCGGGCCGGGGTGGTC	0.612000													59	66					0	0	1	0	0
LPGAT1	9926	broad.mit.edu	37	1	212002548	212002548	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:212002548C>A	ENST00000366997.4	-	2	317	c.91G>T	c.(91-93)Gtt>Ttt	p.V31F	LPGAT1_ENST00000366996.1_Missense_Mutation_p.V31F|LPGAT1_ENST00000488600.1_5'UTR	NM_014873.2	NP_055688.1	Q92604	LGAT1_HUMAN	lysophosphatidylglycerol acyltransferase 1	31					phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity			breast(1)|endometrium(2)|large_intestine(1)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	16				OV - Ovarian serous cystadenocarcinoma(81;0.00773)|all cancers(67;0.0765)|Epithelial(68;0.114)		GGAATAGCAACCAGGTTGTTG	0.463000													108	141					2.66069e-56	3.8148e-56	1	1	0
FCRL4	83417	broad.mit.edu	37	1	157557731	157557731	+	Silent	SNP	A	A	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:157557731A>G	ENST00000271532.1	-	4	621	c.486T>C	c.(484-486)aaT>aaC	p.N162N	FCRL4_ENST00000448509.2_5'UTR	NM_031282.2	NP_112572.1	Q96PJ5	FCRL4_HUMAN	Fc receptor-like 4	162	Ig-like C2-type 2.					integral to membrane|plasma membrane	receptor activity			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(5)|lung(20)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	40	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.245)				GATAATTGCCATTGTTATTTG	0.308000													13	14					0	0	1	0	0
CEP290	80184	broad.mit.edu	37	12	88530508	88530508	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:88530508C>T	ENST00000552810.1	-	6	696	c.353G>A	c.(352-354)tGc>tAc	p.C118Y	CEP290_ENST00000309041.7_Missense_Mutation_p.C118Y	NM_025114.3	NP_079390.3	O15078	CE290_HUMAN	centrosomal protein 290kDa	118					cilium assembly|eye photoreceptor cell development|G2/M transition of mitotic cell cycle|hindbrain development|otic vesicle formation|positive regulation of transcription, DNA-dependent|pronephros development|protein transport	cell surface|centrosome|cytosol|nucleus|photoreceptor connecting cilium	protein binding			breast(4)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(20)|liver(1)|lung(18)|ovary(5)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	73						TTCAAGTTGGCAAATTTCATT	0.338000													20	38					0	0	1	0	0
MAP10	54627	broad.mit.edu	37	1	232942439	232942439	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:232942439G>T	ENST00000418460.1	+	1	1797	c.1670G>T	c.(1669-1671)aGt>aTt	p.S557I		NM_019090.2	NP_061963.2			microtubule-associated protein 10																		CCTGTGACAAGTCCTGCTCAT	0.413000													21	62					3.62473e-10	3.94645e-10	1	1	0
CPNE3	8895	broad.mit.edu	37	8	87568404	87568404	+	Missense_Mutation	SNP	T	T	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr8:87568404T>G	ENST00000521271.1	+	16	1491	c.1329T>G	c.(1327-1329)aaT>aaG	p.N443K	CPNE3_ENST00000198765.4_Missense_Mutation_p.N443K	NM_003909.3	NP_003900.1	O75131	CPNE3_HUMAN	copine III	443	VWFA.				lipid metabolic process|vesicle-mediated transport	cytosol	calcium-dependent phospholipid binding|protein serine/threonine kinase activity|transporter activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	23						CTATAGTTAATGCCTCCAGGC	0.458000													62	63					0	0	1	0	0
PTPRN2	5799	broad.mit.edu	37	7	157874068	157874068	+	Splice_Site	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:157874068C>A	ENST00000389413.3	-	10	1661	c.1558G>T	c.(1558-1560)Gtt>Ttt	p.V520F	PTPRN2_ENST00000389418.4_Splice_Site_p.V549F|PTPRN2_ENST00000409483.1_Splice_Site_p.V511F|PTPRN2_ENST00000404321.2_Splice_Site_p.V572F|PTPRN2_ENST00000389416.4_Splice_Site_p.V532F	NM_130843.2	NP_570858.2	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N polypeptide 2	549						integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(1)|lung(42)|ovary(4)|pleura(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	86	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		GGTCCGAGAACCCTGGAAGGG	0.473000													49	44					1.05386e-31	1.4154e-31	1	1	0
SREBF1	6720	broad.mit.edu	37	17	17719174	17719174	+	Splice_Site	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:17719174C>G	ENST00000355815.4	-	13	2642	c.2473G>C	c.(2473-2475)Gtg>Ctg	p.V825L	SREBF1_ENST00000261646.5_Splice_Site_p.V795L|SREBF1_ENST00000395757.1_Splice_Site_p.V541L|SREBF1_ENST00000338854.5_Splice_Site_p.V795L	NM_001005291.2	NP_001005291.1	P36956	SRBP1_HUMAN	sterol regulatory element binding transcription factor 1	795					cellular response to starvation|cholesterol metabolic process|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter	endoplasmic reticulum|endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleus	protein binding|sequence-specific DNA binding transcription factor activity|sterol response element binding			cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(5)|skin(1)|urinary_tract(1)	14						AAGAGAGCACCTGGGTTCCCG	0.627000													8	21					0	0	1	0	0
DCLRE1A	9937	broad.mit.edu	37	10	115596934	115596934	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:115596934C>G	ENST00000361384.2	-	8	3766	c.2849G>C	c.(2848-2850)gGt>gCt	p.G950A	DCLRE1A_ENST00000369305.1_Missense_Mutation_p.G950A	NM_014881.3	NP_055696.3	Q6PJP8	DCR1A_HUMAN	DNA cross-link repair 1A	950					cell division|mitosis	nucleus	hydrolase activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|prostate(1)|skin(2)|urinary_tract(1)	31				Epithelial(162;0.0157)|all cancers(201;0.0171)		GTATTTCCCACCACACTTCTT	0.373000								Other identified genes with known or suspected DNA repair function					43	43					0	0	1	0	0
C6orf62	81688	broad.mit.edu	37	6	24716501	24716501	+	Missense_Mutation	SNP	T	T	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:24716501T>G	ENST00000378119.4	-	2	2348	c.181A>C	c.(181-183)Aat>Cat	p.N61H	C6orf62_ENST00000540769.1_Missense_Mutation_p.N3H|C6orf62_ENST00000378102.3_Missense_Mutation_p.N32H	NM_030939.4	NP_112201.1	Q9GZU0	CF062_HUMAN	chromosome 6 open reading frame 62	61						intracellular				endometrium(2)|kidney(3)|large_intestine(2)|lung(3)	10						TCATAATTATTTGTCATGACT	0.398000													34	34					0	0	1	0	0
MAMDC4	158056	broad.mit.edu	37	9	139751262	139751262	+	Missense_Mutation	SNP	C	C	A	rs142680518		TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:139751262C>A	ENST00000445819.1	+	17	2108	c.2058C>A	c.(2056-2058)gaC>gaA	p.D686E	MAMDC4_ENST00000317446.2_Missense_Mutation_p.D607E|MAMDC4_ENST00000485732.1_3'UTR			Q6UXC1	AEGP_HUMAN	MAM domain containing 4	686	MAM 4.				protein transport	integral to membrane				breast(4)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(4)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	19	all_cancers(76;0.0763)|all_epithelial(76;0.198)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.52e-05)|Epithelial(140;0.000171)		CTGACCACGACCACACCACAG	0.647000													12	16					4.36969e-10	4.74817e-10	1	1	0
SAMD14	201191	broad.mit.edu	37	17	48195665	48195665	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:48195665C>T	ENST00000330175.4	-	3	387	c.70G>A	c.(70-72)Gcc>Acc	p.A24T	SAMD14_ENST00000503734.1_5'UTR|SAMD14_ENST00000503131.1_Missense_Mutation_p.A24T	NM_001257359.1	NP_001244288.1	Q8IZD0	SAM14_HUMAN	sterile alpha motif domain containing 14	24										breast(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(3)|prostate(1)|urinary_tract(1)	15						TCCAGTCTGGCCGTCTCTGGC	0.662000													95	83					0	0	1	0	0
CUBN	8029	broad.mit.edu	37	10	16883004	16883004	+	Missense_Mutation	SNP	A	A	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:16883004A>G	ENST00000377833.4	-	61	9771	c.9706T>C	c.(9706-9708)Ttt>Ctt	p.F3236L		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	3236	CUB 24.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GAACCACAAAACGTTCCAGCC	0.368000													20	21					0	0	1	0	0
EYA1	2138	broad.mit.edu	37	8	72211327	72211327	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr8:72211327G>C	ENST00000340726.3	-	9	1420	c.781C>G	c.(781-783)Ccg>Gcg	p.P261A	EYA1_ENST00000303824.7_Missense_Mutation_p.P255A|EYA1_ENST00000388743.2_Missense_Mutation_p.P260A|EYA1_ENST00000419131.1_Missense_Mutation_p.P256A|EYA1_ENST00000388741.2_Missense_Mutation_p.P227A|EYA1_ENST00000388740.3_Missense_Mutation_p.P228A|EYA1_ENST00000388742.4_Missense_Mutation_p.P261A	NM_000503.4	NP_000494.2	Q99502	EYA1_HUMAN	eyes absent homolog 1 (Drosophila)	261					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			NS(2)|breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(15)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	44	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			CCAGATGGCGGTTCTTGAAGC	0.453000													51	78					0	0	1	0	0
MORC3	23515	broad.mit.edu	37	21	37721694	37721694	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr21:37721694C>A	ENST00000400485.1	+	9	1167	c.1091C>A	c.(1090-1092)aCt>aAt	p.T364N	MORC3_ENST00000487909.1_3'UTR	NM_015358.2	NP_056173.1	Q14149	MORC3_HUMAN	MORC family CW-type zinc finger 3	364					cell aging|maintenance of protein location in nucleus|negative regulation of fibroblast proliferation|peptidyl-serine phosphorylation|protein stabilization	aggresome|intermediate filament cytoskeleton|PML body	ATP binding|zinc ion binding			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(9)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	35						TTCGACTATACTAATGAGTAC	0.328000													17	20					1.99824e-07	2.09701e-07	1	1	0
ACTL7B	10880	broad.mit.edu	37	9	111618174	111618174	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:111618174C>A	ENST00000374667.3	-	1	1065	c.37G>T	c.(37-39)Gct>Tct	p.A13S		NM_006686.3	NP_006677.1	Q9Y614	ACL7B_HUMAN	actin-like 7B	13						actin cytoskeleton|cytoplasm	structural constituent of cytoskeleton			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(8)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20						TCACCCTGAGCCGTGCCCAGG	0.652000													7	94					3.09899e-07	3.246e-07	1	1	0
ARHGAP15	55843	broad.mit.edu	37	2	143959730	143959730	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:143959730C>T	ENST00000409869.1	+	4	370	c.193C>T	c.(193-195)Cag>Tag	p.Q65*	ARHGAP15_ENST00000295095.6_Nonsense_Mutation_p.Q65*			Q53QZ3	RHG15_HUMAN	Rho GTPase activating protein 15	65					regulation of cell shape|small GTPase mediated signal transduction	cytosol|membrane	protein binding|Rac GTPase activator activity			endometrium(1)|kidney(5)|large_intestine(8)|liver(2)|lung(15)|ovary(1)|skin(2)	34				BRCA - Breast invasive adenocarcinoma(221;0.151)		GAATCATTCACAGCATATCTT	0.299000													25	53					0	0	1	0	0
DPF3	8110	broad.mit.edu	37	14	73137957	73137957	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:73137957C>G	ENST00000541685.1	-	9	973	c.961G>C	c.(961-963)Gac>Cac	p.D321H	DPF3_ENST00000557704.1_5'UTR|DPF3_ENST00000546183.1_Missense_Mutation_p.D331H|DPF3_ENST00000556509.1_Intron	NM_012074.3	NP_036206.3	Q92784	DPF3_HUMAN	D4, zinc and double PHD fingers, family 3	149					chromatin modification|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nBAF complex	nucleic acid binding|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)	22				BRCA - Breast invasive adenocarcinoma(234;0.00649)|OV - Ovarian serous cystadenocarcinoma(108;0.0654)		GTTGACGTGTCACTTTCTGAC	0.562000													48	49					0	0	1	0	0
ZNF646	9726	broad.mit.edu	37	16	31088322	31088322	+	Missense_Mutation	SNP	A	A	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:31088322A>G	ENST00000394979.2	+	1	1100	c.677A>G	c.(676-678)gAg>gGg	p.E226G	ZNF646_ENST00000300850.5_Missense_Mutation_p.E226G			O15015	ZN646_HUMAN	zinc finger protein 646	226					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(8)|kidney(4)|large_intestine(1)|lung(21)|ovary(1)|prostate(4)|skin(3)	49						GGGGGCCAGGAGCCCACCCAG	0.602000													39	42					0	0	1	0	0
WDFY3	23001	broad.mit.edu	37	4	85598394	85598394	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:85598394C>G	ENST00000322366.6	-	66	10771	c.10364G>C	c.(10363-10365)aGa>aCa	p.R3455T	WDFY3_ENST00000295888.4_Missense_Mutation_p.R3472T			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	3472						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		ATGGTGTCGTCTTTCTGTGAG	0.468000													35	71					0	0	1	0	0
FAM111B	374393	broad.mit.edu	37	11	58893494	58893494	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:58893494G>C	ENST00000343597.3	+	4	2115	c.1924G>C	c.(1924-1926)Gat>Cat	p.D642H	FAM111B_ENST00000411426.1_Missense_Mutation_p.D612H|FAM111B_ENST00000529618.1_Missense_Mutation_p.D612H	NM_198947.3	NP_945185.1	Q6SJ93	F111B_HUMAN	family with sequence similarity 111, member B	642							catalytic activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|liver(1)|lung(12)|ovary(3)|pancreas(1)|skin(1)	40						GCTTAGTTATGATACTTGTTT	0.413000													35	41					0	0	1	0	0
VPS13C	54832	broad.mit.edu	37	15	62146695	62146695	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr15:62146695C>A	ENST00000261517.5	-	85	11296	c.11223G>T	c.(11221-11223)caG>caT	p.Q3741H	VPS13C_ENST00000249837.3_Missense_Mutation_p.Q3698H	NM_020821.2	NP_065872.1	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13 homolog C (S. cerevisiae)	3741					protein localization					NS(3)|breast(4)|endometrium(4)|kidney(9)|large_intestine(26)|lung(46)|ovary(5)|prostate(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	117						TCACTGATGACTGCTTCATCA	0.398000													112	135					1.37143e-49	1.94111e-49	1	1	0
LAMA2	3908	broad.mit.edu	37	6	129636975	129636975	+	Silent	SNP	T	T	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:129636975T>C	ENST00000421865.2	+	26	3853	c.3804T>C	c.(3802-3804)tcT>tcC	p.S1268S		NM_000426.3|NM_001079823.1	NP_000417|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	1268	Laminin IV type A 2.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		CAGGTTTCTCTACATATAATC	0.438000													62	58					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9068085	9068085	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:9068085G>A	ENST00000397910.4	-	3	19564	c.19361C>T	c.(19360-19362)gCg>gTg	p.A6454V		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	6456	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding	p.A6454V(2)|p.A6454E(2)|p.A2087V(1)|p.A2087E(1)		NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CTGTGATGTCGCCCTATGAGG	0.498000													91	433					0	0	1	0	0
PKD1	5310	broad.mit.edu	37	16	2168842	2168842	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:2168842G>A	ENST00000262304.4	-	4	572	c.364C>T	c.(364-366)Ctg>Ttg	p.L122L	PKD1_ENST00000423118.1_Silent_p.L122L	NM_001009944.2	NP_001009944	P98161	PKD1_HUMAN	polycystic kidney disease 1 (autosomal dominant)	122					calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|lung(34)|prostate(4)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						TTCCCACTCAGGTTTCTGCAG	0.682000													8	38					0	0	1	0	0
ENTHD2	146705	broad.mit.edu	37	17	79207838	79207838	+	Silent	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:79207838C>G	ENST00000300714.3	-	5	375	c.318G>C	c.(316-318)ggG>ggC	p.G106G	ENTHD2_ENST00000374769.2_5'UTR	NM_144679.2	NP_653280.1			ENTH domain containing 2																		GATCTGGGGGCCCTGCAAAAG	0.677000													32	29					0	0	1	0	0
WDR17	116966	broad.mit.edu	37	4	177098267	177098267	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:177098267G>A	ENST00000393643.2	+	28	3805	c.3553G>A	c.(3553-3555)Gaa>Aaa	p.E1185K	WDR17_ENST00000508596.1_Missense_Mutation_p.E1170K|WDR17_ENST00000507824.2_Missense_Mutation_p.E1184K|WDR17_ENST00000280190.4_Missense_Mutation_p.E1209K	NM_170710.4	NP_733828.2	Q8IZU2	WDR17_HUMAN	WD repeat domain 17	1209										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(18)|lung(46)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	92		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		TCTTTCTGAGGAATTGGATGC	0.363000													21	48					0	0	1	0	0
CDKL5	6792	broad.mit.edu	37	X	18622501	18622501	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chrX:18622501C>A	ENST00000379989.3	+	13	1742	c.1457C>A	c.(1456-1458)gCc>gAc	p.A486D	CDKL5_ENST00000379996.3_Missense_Mutation_p.A486D|CDKL5_ENST00000463994.1_3'UTR	NM_001037343.1	NP_001032420.1	O76039	CDKL5_HUMAN	cyclin-dependent kinase-like 5	486					neuron migration|positive regulation of axon extension|positive regulation of dendrite morphogenesis|positive regulation of Rac GTPase activity|protein autophosphorylation	dendrite cytoplasm|dendritic growth cone|nucleus	ATP binding|cyclin-dependent protein kinase activity|Rac GTPase binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(12)|ovary(4)|skin(5)|stomach(1)	44	Hepatocellular(33;0.183)					AGGACCAAGGCCAAAAGCCAT	0.532000													65	11					3.8688e-20	4.69358e-20	1	1	0
MAVS	57506	broad.mit.edu	37	20	3845324	3845324	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:3845324G>T	ENST00000428216.2	+	6	1175	c.1047G>T	c.(1045-1047)ttG>ttT	p.L349F	MAVS_ENST00000358134.6_3'UTR|MAVS_ENST00000416600.2_Missense_Mutation_p.L208F	NM_020746.4	NP_065797.2	Q7Z434	MAVS_HUMAN	mitochondrial antiviral signaling protein	349					activation of innate immune response|cellular response to exogenous dsRNA|defense response to bacterium|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of chemokine (C-C motif) ligand 5 production|positive regulation of defense response to virus by host|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interleukin-8 production|positive regulation of IP-10 production|positive regulation of protein import into nucleus, translocation|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of type I interferon-mediated signaling pathway|response to virus	integral to membrane|mitochondrial outer membrane	CARD domain binding|protein kinase binding|signal transducer activity			autonomic_ganglia(1)|breast(3)|endometrium(1)|large_intestine(3)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	14						CATCCAAATTGCCCATCAACT	0.567000													54	156					1.4374e-25	1.84094e-25	1	1	0
ZXDA	7789	broad.mit.edu	37	X	57936038	57936038	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chrX:57936038G>A	ENST00000358697.4	-	1	1029	c.817C>T	c.(817-819)Ctg>Ttg	p.L273L		NM_007156.4	NP_009087.1	P98168	ZXDA_HUMAN	zinc finger, X-linked, duplicated A	273	Required for interaction with ZXDC.				positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(9)|kidney(1)|large_intestine(7)|lung(13)|ovary(2)|prostate(2)|skin(1)	37						TGCCCGCACAGCGCCTCGGGG	0.711000													7	2					0	0	1	0	0
CCDC18	343099	broad.mit.edu	37	1	93667528	93667528	+	Translation_Start_Site	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:93667528G>A	ENST00000334652.5	+	0	1300				CCDC18_ENST00000401026.3_Missense_Mutation_p.A260T|CCDC18_ENST00000343253.7_Missense_Mutation_p.A260T|CCDC18_ENST00000557479.1_Missense_Mutation_p.A378T|CCDC18_ENST00000338949.4_Missense_Mutation_p.A59T			Q5T9S5	CCD18_HUMAN	coiled-coil domain containing 18											breast(5)|endometrium(3)|kidney(1)|large_intestine(6)|lung(19)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	42		all_lung(203;0.00196)|Lung NSC(277;0.00903)|Melanoma(281;0.099)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00166)|GBM - Glioblastoma multiforme(16;0.00551)|Epithelial(280;0.0967)		AAAAAAAGTGGCTGAAAAACT	0.308000													17	17					0	0	1	0	0
COL1A1	1277	broad.mit.edu	37	17	48269225	48269225	+	Missense_Mutation	SNP	T	T	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:48269225T>C	ENST00000225964.5	-	31	2169	c.2051A>G	c.(2050-2052)gAg>gGg	p.E684G		NM_000088.3	NP_000079	P02452	CO1A1_HUMAN	collagen, type I, alpha 1	684	Triple-helical region.				axon guidance|blood vessel development|collagen biosynthetic process|collagen fibril organization|embryonic skeletal system development|leukocyte migration|platelet activation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|protein localization to nucleus|sensory perception of sound|skin morphogenesis|tooth mineralization|visual perception	collagen type I|extracellular space|plasma membrane	identical protein binding|platelet-derived growth factor binding		COL1A1/PDGFB(429)	NS(1)|breast(3)|central_nervous_system(8)|endometrium(3)|kidney(4)|large_intestine(17)|liver(3)|lung(18)|ovary(1)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	71					Collagenase(DB00048)|Palifermin(DB00039)	CACACCACGCTCGCCAGGGAA	0.642000			T	"""PDGFB, USP6"""	"""dermatofibrosarcoma protuberans, aneurysmal bone cyst """		Osteogenesis imperfecta						19	23					0	0	1	0	0
OR56A1	120796	broad.mit.edu	37	11	6048854	6048854	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:6048854G>T	ENST00000316650.5	-	1	117	c.81C>A	c.(79-81)ttC>ttA	p.F27L		NM_001001917.2	NP_001001917.2	Q8NGH5	O56A1_HUMAN	olfactory receptor, family 56, subfamily A, member 1	27					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(22)|ovary(2)	33		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCCAACTCTGGAAGTTGGGGA	0.572000													64	5					7.75977e-34	1.04985e-33	1	1	0
NRP2	8828	broad.mit.edu	37	2	206631519	206631519	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:206631519C>T	ENST00000360409.3	+	15	3208	c.2417C>T	c.(2416-2418)gCt>gTt	p.A806V	NRP2_ENST00000357118.4_Missense_Mutation_p.A806V|NRP2_ENST00000540178.1_Intron|NRP2_ENST00000540841.1_Intron|NRP2_ENST00000412873.2_Missense_Mutation_p.A806V|NRP2_ENST00000272849.3_Missense_Mutation_p.A806V|NRP2_ENST00000485684.1_3'UTR|NRP2_ENST00000357785.5_Missense_Mutation_p.A806V	NM_003872.2|NM_201266.1|NM_201279.1	NP_003863.2|NP_957718|NP_958436.1	O60462	NRP2_HUMAN	neuropilin 2	806					angiogenesis|axon guidance|cell adhesion	integral to membrane|membrane fraction|plasma membrane	heparin binding|metal ion binding|semaphorin receptor activity|vascular endothelial growth factor receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(14)|lung(19)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	52						CCCATCTCGGCTTTTGCAGGT	0.343000											OREG0015156	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	24					0	0	1	0	0
AMBN	258	broad.mit.edu	37	4	71472154	71472154	+	Missense_Mutation	SNP	G	G	A	rs141401324		TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:71472154G>A	ENST00000322937.6	+	13	1154	c.1051G>A	c.(1051-1053)Gca>Aca	p.A351T	AMBN_ENST00000449493.2_Missense_Mutation_p.A336T	NM_016519.5	NP_057603.1	Q9NP70	AMBN_HUMAN	ameloblastin (enamel matrix protein)	351					bone mineralization|cell adhesion|cell proliferation|odontogenesis of dentine-containing tooth	proteinaceous extracellular matrix	growth factor activity|structural constituent of tooth enamel			NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(1)	29			Lung(101;0.235)			TGCTCCCCACGCAGGGCTCCT	0.587000													11	40					0	0	1	0	0
MYLK3	91807	broad.mit.edu	37	16	46764580	46764580	+	Missense_Mutation	SNP	T	T	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:46764580T>C	ENST00000394809.4	-	5	1608	c.1493A>G	c.(1492-1494)gAa>gGa	p.E498G	MYLK3_ENST00000536476.1_Missense_Mutation_p.E157G	NM_182493.2	NP_872299.2	Q32MK0	MYLK3_HUMAN	myosin light chain kinase 3	498					cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(7)|lung(11)|ovary(3)|prostate(3)|skin(5)|stomach(3)	37		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				TACCCGGTGTTCAAAAGGAGC	0.602000													46	92					0	0	1	0	0
DCAF8	50717	broad.mit.edu	37	1	160209813	160209813	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:160209813C>A	ENST00000368073.3	-	4	831	c.397G>T	c.(397-399)Gag>Tag	p.E133*	DCAF8_ENST00000368074.1_Nonsense_Mutation_p.E133*|DCAF8_ENST00000608310.1_Nonsense_Mutation_p.E287*|DCAF8_ENST00000556710.1_Nonsense_Mutation_p.E287*|DCAF8_ENST00000475733.1_Nonsense_Mutation_p.E133*|DCAF8_ENST00000326837.2_Nonsense_Mutation_p.E133*|DCAF8_ENST00000610139.1_Nonsense_Mutation_p.E133*			Q5TAQ9	DCAF8_HUMAN	DDB1 and CUL4 associated factor 8	133						CUL4 RING ubiquitin ligase complex	protein binding			cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(16)|skin(3)|upper_aerodigestive_tract(1)	33						AGGGCCCGCTCATCATCTGAT	0.612000													46	80					3.21987e-24	4.03947e-24	1	1	0
BEST3	144453	broad.mit.edu	37	12	70070774	70070774	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:70070774G>A	ENST00000330891.5	-	7	1015	c.789C>T	c.(787-789)ggC>ggT	p.G263G	BEST3_ENST00000488961.1_Intron|BEST3_ENST00000331471.4_Silent_p.G263G|BEST3_ENST00000553096.1_Silent_p.G157G|BEST3_ENST00000476098.1_Intron	NM_001282613.1|NM_032735.2	NP_001269542.1|NP_116124.2	Q8N1M1	BEST3_HUMAN	bestrophin 3	263						chloride channel complex|plasma membrane	chloride channel activity			cervix(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(2)	12	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			GCCCTGCGTAGCCTTTGGTGG	0.502000													59	49					0	0	1	0	0
INSL4	3641	broad.mit.edu	37	9	5233806	5233806	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:5233806C>A	ENST00000239316.4	+	2	454	c.349C>A	c.(349-351)Cgt>Agt	p.R117S		NM_002195.1	NP_002186.1	Q14641	INSL4_HUMAN	insulin-like 4 (placenta)	117					cell proliferation|cell-cell signaling|female pregnancy|multicellular organismal development|signal transduction	extracellular space|soluble fraction	hormone activity|insulin-like growth factor receptor binding	p.R117C(1)		endometrium(2)|lung(2)|skin(1)|urinary_tract(1)	6	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0201)|Lung(218;0.14)		GAGAAGTGGACGTCACAGATT	0.383000													29	5					5.60225e-13	6.32401e-13	1	1	0
MMRN1	22915	broad.mit.edu	37	4	90856744	90856744	+	Missense_Mutation	SNP	A	A	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:90856744A>G	ENST00000394980.1	+	7	2232	c.1913A>G	c.(1912-1914)cAa>cGa	p.Q638R	MMRN1_ENST00000508372.1_Missense_Mutation_p.Q380R|MMRN1_ENST00000264790.2_Missense_Mutation_p.Q638R|MMRN1_ENST00000394981.1_Intron			Q13201	MMRN1_HUMAN	multimerin 1	638					cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|liver(2)|lung(34)|ovary(5)|prostate(1)|skin(6)|stomach(1)|urinary_tract(2)	72		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		ATGAGTGAGCAACTAAATGAT	0.378000													38	66					0	0	1	0	0
NEDD4	4734	broad.mit.edu	37	15	56152722	56152722	+	Silent	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr15:56152722G>T	ENST00000508342.1	-	7	2399	c.2100C>A	c.(2098-2100)gcC>gcA	p.A700A	NEDD4_ENST00000435532.3_Silent_p.A281A|NEDD4_ENST00000338963.2_Silent_p.A628A|NEDD4_ENST00000506154.1_Silent_p.A684A	NM_001284338.1	NP_001271267.1	P46934	NEDD4_HUMAN	neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase	700	Mediates interaction with TNIK (By similarity).				development involved in symbiotic interaction|glucocorticoid receptor signaling pathway|negative regulation of sodium ion transport|negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|negative regulation of vascular endothelial growth factor receptor signaling pathway|neuron projection development|positive regulation of nucleocytoplasmic transport|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein catabolic process|progesterone receptor signaling pathway|protein K63-linked ubiquitination|protein targeting to lysosome|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|receptor internalization|regulation of dendrite morphogenesis|response to calcium ion|transmission of virus	apicolateral plasma membrane|cell cortex|chromatin|cytosol|perinuclear region of cytoplasm|ubiquitin ligase complex	beta-2 adrenergic receptor binding|phosphoserine binding|phosphothreonine binding|proline-rich region binding|protein domain specific binding|RNA polymerase binding|sodium channel inhibitor activity|ubiquitin binding|ubiquitin-protein ligase activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(15)|ovary(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	43				all cancers(107;0.0299)|GBM - Glioblastoma multiforme(80;0.113)		GTGATGGGAAGGCCTGGTTGC	0.423000													11	66					5.50884e-06	5.68388e-06	1	1	0
FBN3	84467	broad.mit.edu	37	19	8176067	8176067	+	Splice_Site	SNP	T	T	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:8176067T>C	ENST00000600128.1	-	33	4499	c.4085A>G	c.(4084-4086)gAc>gGc	p.D1362G	FBN3_ENST00000270509.2_Splice_Site_p.D1362G|FBN3_ENST00000601739.1_Splice_Site_p.D1362G			Q75N90	FBN3_HUMAN	fibrillin 3	1362	EGF-like 21; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						TTCATCCCTGTCTGAGGGGCC	0.637000													35	197					0	0	1	0	0
GRID2	2895	broad.mit.edu	37	4	94343960	94343960	+	Silent	SNP	T	T	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:94343960T>A	ENST00000282020.4	+	10	1644	c.1386T>A	c.(1384-1386)ggT>ggA	p.G462G	GRID2_ENST00000510992.1_Silent_p.G367G	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	462				G -> C (in Ref. 1; AAC39579).	glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	ATGTCTTGGGTAAGCCGAAGA	0.383000													33	33					0	0	1	0	0
PNPLA3	80339	broad.mit.edu	37	22	44332964	44332964	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr22:44332964C>T	ENST00000216180.3	+	6	964	c.791C>T	c.(790-792)tCa>tTa	p.S264L	PNPLA3_ENST00000423180.2_Missense_Mutation_p.S260L	NM_025225.2	NP_079501.2	Q9NST1	PLPL3_HUMAN	patatin-like phospholipase domain containing 3	264					triglyceride biosynthetic process|triglyceride catabolic process	integral to membrane	diolein transacylation activity|mono-olein transacylation activity|phospholipase A2 activity|triglyceride lipase activity			cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(3)|prostate(1)|skin(1)|stomach(2)	19		Ovarian(80;0.024)|all_neural(38;0.0416)				GGCCTGAAGTCATCCTCAGAA	0.602000													23	36					0	0	1	0	0
SIPA1	6494	broad.mit.edu	37	11	65417137	65417137	+	Silent	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:65417137G>C	ENST00000394224.3	+	11	2927	c.2631G>C	c.(2629-2631)ctG>ctC	p.L877L	SIPA1_ENST00000534313.1_Silent_p.L877L|SIPA1_ENST00000394227.3_Silent_p.L775L|SIPA1_ENST00000527525.1_Silent_p.L775L	NM_153253.29	NP_694985.29	Q96FS4	SIPA1_HUMAN	signal-induced proliferation-associated 1	877					cell proliferation|cytoskeleton organization|intracellular signal transduction|negative regulation of cell adhesion|negative regulation of cell cycle|negative regulation of cell growth	cytosol|endomembrane system|membrane|perinuclear region of cytoplasm	Rap GTPase activator activity			cervix(1)|endometrium(2)|large_intestine(2)|lung(3)|prostate(1)|urinary_tract(1)	10						AGACACCCCTGACCCAGGTGA	0.607000													68	65					0	0	1	0	0
HMGCLL1	54511	broad.mit.edu	37	6	55378838	55378838	+	Nonstop_Mutation	SNP	A	A	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:55378838A>T	ENST00000428842.1	-	4	471	c.454T>A	c.(454-456)Tga>Aga	p.*152R	HMGCLL1_ENST00000308161.4_Intron|HMGCLL1_ENST00000508459.1_Intron|HMGCLL1_ENST00000370850.2_Intron|HMGCLL1_ENST00000274901.4_Intron|HMGCLL1_ENST00000398661.2_Intron			Q8TB92	HMGC2_HUMAN	3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1	0							hydroxymethylglutaryl-CoA lyase activity|metal ion binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	31	Lung NSC(77;0.0875)		LUSC - Lung squamous cell carcinoma(124;0.23)			GTGGGATTTCATAAGTACCCT	0.289000													39	32					0	0	1	0	0
UBE2S	27338	broad.mit.edu	37	19	55915730	55915730	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:55915730C>A	ENST00000264552.9	-	3	455	c.268G>T	c.(268-270)Gcc>Tcc	p.A90S	UBE2S_ENST00000589978.1_Missense_Mutation_p.R64L	NM_014501.2	NP_055316.2	Q16763	UBE2S_HUMAN	ubiquitin-conjugating enzyme E2S	90					activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|exit from mitosis|free ubiquitin chain polymerization|protein K11-linked ubiquitination|protein K27-linked ubiquitination|protein K29-linked ubiquitination|protein K6-linked ubiquitination|protein K63-linked ubiquitination	anaphase-promoting complex	ATP binding|ubiquitin-protein ligase activity			lung(1)	1	Breast(117;0.155)		LUSC - Lung squamous cell carcinoma(43;0.13)|BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.11)		TCGCCATTGGCGCCCACGTTC	0.617000													32	22					2.37825e-27	3.07446e-27	1	1	0
EFNA1	1942	broad.mit.edu	37	1	155104034	155104034	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:155104034G>A	ENST00000368407.3	+	2	830	c.312G>A	c.(310-312)ctG>ctA	p.L104L	EFNA1_ENST00000368406.2_Silent_p.L104L|EFNA1_ENST00000469878.1_3'UTR	NM_004428.2	NP_004419.2	P20827	EFNA1_HUMAN	ephrin-A1	104					angiogenesis|aortic valve morphogenesis|cell migration|cell-cell signaling|endocardial cushion to mesenchymal transition involved in heart valve formation|ephrin receptor signaling pathway|mitral valve morphogenesis|negative regulation of epithelial to mesenchymal transition|negative regulation of transcription from RNA polymerase II promoter|positive regulation of peptidyl-tyrosine phosphorylation|regulation of cell adhesion mediated by integrin|substrate adhesion-dependent cell spreading	extracellular region|integral to plasma membrane	ephrin receptor binding			breast(1)|endometrium(1)|kidney(1)|lung(1)|skin(1)	5	all_epithelial(22;4.71e-30)|all_lung(78;3.15e-27)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;2.28e-10)|all cancers(21;6.16e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000395)|LUSC - Lung squamous cell carcinoma(543;0.193)			CGGAGAAGCTGTCTGAGAAGT	0.582000													22	41					0	0	1	0	0
TRAJ29	28726	broad.mit.edu	37	14	22982966	22982966	+	RNA	SNP	T	T	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:22982966T>A	ENST00000390508.1	+	0	46																											GGCACAAGACTTTCTGTGATT	0.423000													50	77					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126336381	126336381	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:126336381C>T	ENST00000394329.3	+	5	6276	c.6263C>T	c.(6262-6264)aCt>aTt	p.T2088I	FAT4_ENST00000335110.5_Missense_Mutation_p.T386I	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	2088	Cadherin 20.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						ATTGAGTACACTCTGCTGAAC	0.403000													97	91					0	0	1	0	0
PEX3	8504	broad.mit.edu	37	6	143784110	143784110	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:143784110G>A	ENST00000367591.4	+	3	326	c.263G>A	c.(262-264)aGc>aAc	p.S88N		NM_003630.2	NP_003621.1	P56589	PEX3_HUMAN	peroxisomal biogenesis factor 3	88					protein import into peroxisome membrane|transmembrane transport	integral to peroxisomal membrane	protein binding			endometrium(1)|large_intestine(9)|lung(4)|ovary(2)|skin(2)	18				OV - Ovarian serous cystadenocarcinoma(155;5.73e-06)|GBM - Glioblastoma multiforme(68;0.0117)		AATTCCGAGAGCCTCACAGCT	0.358000													38	33					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110489565	110489565	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr8:110489565G>A	ENST00000378402.5	+	53	9133	c.9029G>A	c.(9028-9030)tGc>tAc	p.C3010Y		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	3010					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			CTCCAGGATTGCTTTCCTGTA	0.413000										HNSCC(38;0.096)			31	25					0	0	1	0	0
SGIP1	84251	broad.mit.edu	37	1	67147961	67147961	+	Missense_Mutation	SNP	A	A	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:67147961A>T	ENST00000371037.4	+	15	1301	c.1224A>T	c.(1222-1224)agA>agT	p.R408S	SGIP1_ENST00000237247.6_Missense_Mutation_p.R412S|SGIP1_ENST00000371039.1_Intron|SGIP1_ENST00000371035.3_Intron|SGIP1_ENST00000371036.3_Intron	NM_032291.2	NP_115667.2	Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting protein 1	408	Pro-rich.				positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(43)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	71						TGGGACAAAGAGCAACTCCAC	0.512000													26	179					0	0	1	0	0
MRPL3	11222	broad.mit.edu	37	3	131208827	131208827	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:131208827G>T	ENST00000264995.3	-	5	713	c.566C>A	c.(565-567)cCa>cAa	p.P189Q	MRPL3_ENST00000425847.2_Missense_Mutation_p.P216Q|MRPL3_ENST00000506946.1_5'UTR	NM_007208.3	NP_009139.1	P09001	RM03_HUMAN	mitochondrial ribosomal protein L3	189					translation	mitochondrial large ribosomal subunit	RNA binding|structural constituent of ribosome			endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|urinary_tract(1)	10						CAAATTACCTGGTTTAATTGC	0.363000													11	17					1.61879e-10	1.76595e-10	1	1	0
HECW1	23072	broad.mit.edu	37	7	43503285	43503285	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:43503285C>G	ENST00000395891.2	+	14	3283	c.2678C>G	c.(2677-2679)gCa>gGa	p.A893G	HECW1_ENST00000453890.1_Missense_Mutation_p.A859G	NM_015052.3	NP_055867.3	Q76N89	HECW1_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1						protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			NS(2)|breast(10)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(57)|ovary(8)|pancreas(2)|prostate(2)|skin(6)|urinary_tract(3)	125						CGAACCATTGCAACAGAGAGG	0.498000													51	73					0	0	1	0	0
ZP1	22917	broad.mit.edu	37	11	60635046	60635046	+	Silent	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:60635046C>G	ENST00000278853.5	+	1	12	c.12C>G	c.(10-12)ggC>ggG	p.G4G		NM_207341.2	NP_997224.2	P60852	ZP1_HUMAN	zona pellucida glycoprotein 1 (sperm receptor)	4					single fertilization	integral to membrane|plasma membrane|proteinaceous extracellular matrix				breast(3)|endometrium(2)|large_intestine(8)|lung(8)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	26						TGGCAGGAGGCTCAGCCACGA	0.667000													32	31					0	0	1	0	0
TUBGCP6	85378	broad.mit.edu	37	22	50658876	50658876	+	Silent	SNP	T	T	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr22:50658876T>C	ENST00000439308.2	-	16	4404	c.3912A>G	c.(3910-3912)tcA>tcG	p.S1304S	TUBGCP6_ENST00000248846.5_Silent_p.S1304S|TUBGCP6_ENST00000491449.1_5'UTR	NM_020461.3	NP_065194.2	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	1304					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			breast(4)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(13)|ovary(3)|prostate(2)|skin(2)	45		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		GGCTGAGCGCTGACTGGGACG	0.682000													15	26					0	0	1	0	0
FGFR3	2261	broad.mit.edu	37	4	1803568	1803568	+	Missense_Mutation	SNP	C	C	G	rs121913483		TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:1803568C>G	ENST00000340107.4	+	7	1002	c.746C>G	c.(745-747)tCc>tGc	p.S249C	FGFR3_ENST00000260795.2_Missense_Mutation_p.S249C|FGFR3_ENST00000440486.2_Missense_Mutation_p.S249C|FGFR3_ENST00000481110.2_Missense_Mutation_p.S249C|FGFR3_ENST00000412135.2_Missense_Mutation_p.S249C|FGFR3_ENST00000474521.1_3'UTR|FGFR3_ENST00000352904.1_Missense_Mutation_p.S249C	NM_001163213.1	NP_001156685.1	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3	249			S -> C (in KERSEB, bladder cancer, cervical cancer and TD1).		bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding	p.S249C(1204)|p.R248_S249del(1)		NS(1)|central_nervous_system(5)|cervix(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(40)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(9)|skin(339)|soft_tissue(4)|testis(2)|upper_aerodigestive_tract(58)|urinary_tract(2607)	3091		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	ACAGAGCGCTCCCCGCACCGG	0.736000		1	"""Mis, T"""	"""IGH@, ETV6"""	"""bladder, MM, T-cell lymphoma"""		"""Hypochondroplasia, Thanatophoric dysplasia"""		Saethre-Chotzen syndrome;Muenke syndrome				7	37					0	0	1	0	0
ACBD4	79777	broad.mit.edu	37	17	43220992	43220992	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:43220992G>A	ENST00000431281.1	+	12	1479	c.1010G>A	c.(1009-1011)aGc>aAc	p.S337N	ACBD4_ENST00000321854.8_3'UTR|ACBD4_ENST00000591859.1_Missense_Mutation_p.S337N|ACBD4_ENST00000398322.3_3'UTR|ACBD4_ENST00000592162.1_3'UTR|ACBD4_ENST00000586346.1_Missense_Mutation_p.S337N	NM_001135704.1	NP_001129176.1	Q8NC06	ACBD4_HUMAN	acyl-CoA binding domain containing 4	0							fatty-acyl-CoA binding			kidney(1)|lung(3)|ovary(1)	5						TGTGCCCTGAGCCTTCCTAGG	0.542000													66	0					0	0	1	0	0
ASB10	136371	broad.mit.edu	37	7	150878038	150878038	+	Silent	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:150878038C>G	ENST00000422024.1	-	3	1352	c.1227G>C	c.(1225-1227)ggG>ggC	p.G409G	ASB10_ENST00000420175.2_Silent_p.G364G|ASB10_ENST00000377867.3_Silent_p.G349G|ASB10_ENST00000275838.1_Silent_p.G364G|ASB10_ENST00000434669.1_Silent_p.G409G	NM_001142459.1	NP_001135931.2	Q8WXI3	ASB10_HUMAN	ankyrin repeat and SOCS box containing 10	364					intracellular signal transduction					NS(1)|endometrium(2)|lung(7)|skin(2)	12			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TGGGGAGGGCCCCTGGCCAGA	0.682000													15	15					0	0	1	0	0
MAPK12	6300	broad.mit.edu	37	22	50694610	50694610	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr22:50694610C>G	ENST00000215659.8	-	7	838	c.523G>C	c.(523-525)Gcc>Ccc	p.A175P	MAPK12_ENST00000395780.1_Missense_Mutation_p.A85P|MAPK12_ENST00000497036.1_5'UTR	NM_002969.3	NP_002960.2	P53778	MK12_HUMAN	mitogen-activated protein kinase 12	175	Protein kinase.				cell cycle arrest|DNA damage induced protein phosphorylation|muscle organ development|myoblast differentiation|nerve growth factor receptor signaling pathway|positive regulation of muscle cell differentiation|Ras protein signal transduction	mitochondrion|nucleoplasm	ATP binding|magnesium ion binding|MAP kinase activity|protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(2)|skin(1)	8		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GCCTGCCTGGCCAGGCCGAAG	0.637000													27	46					0	0	1	0	0
WDR1	9948	broad.mit.edu	37	4	10100674	10100674	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:10100674C>A	ENST00000382452.2	-	4	601	c.319G>T	c.(319-321)Gac>Tac	p.D107Y	WDR1_ENST00000502702.1_Intron|WDR1_ENST00000382451.2_Intron|WDR1_ENST00000499869.2_Missense_Mutation_p.D107Y	NM_017491.3	NP_059830.1	O75083	WDR1_HUMAN	WD repeat domain 1	107					platelet activation|platelet degranulation|sensory perception of sound	cytoskeleton|cytosol|extracellular region	actin binding			endometrium(3)|lung(5)|ovary(2)|pancreas(1)|urinary_tract(1)	12				STAD - Stomach adenocarcinoma(129;0.000703)|Colorectal(103;0.0057)|LUSC - Lung squamous cell carcinoma(721;0.0232)		CAAGCAATGTCTTTGATCTTC	0.557000													50	79					2.0833e-19	2.51637e-19	1	1	0
PCDHA6	56142	broad.mit.edu	37	5	140209725	140209725	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:140209725G>A	ENST00000529310.1	+	1	2163	c.2049G>A	c.(2047-2049)tcG>tcA	p.S683S	PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA6_ENST00000527624.1_Intron	NM_018909.2|NM_031848.2|NM_031849.1	NP_061732.1|NP_114036.1|NP_114037.1														NS(1)|breast(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(42)|prostate(8)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	89			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACGGGCGTCGGTGGGCGCCG	0.667000													80	30					0	0	1	0	0
SCN1A	6323	broad.mit.edu	37	2	166901824	166901824	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:166901824G>A	ENST00000423058.2	-	10	1408	c.1391C>T	c.(1390-1392)gCa>gTa	p.A464V	SCN1A_ENST00000375405.3_Missense_Mutation_p.A464V|SCN1A_ENST00000409050.1_Missense_Mutation_p.A464V|AC010127.3_ENST00000595647.1_RNA|AC010127.3_ENST00000595268.1_RNA|AC010127.3_ENST00000599041.1_RNA|SCN1A_ENST00000303395.4_Missense_Mutation_p.A464V	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	464						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	TGAGGCAGTTGCCGTTGCTGC	0.448000													53	91					0	0	1	0	0
SCN1A	6323	broad.mit.edu	37	2	166903446	166903446	+	Missense_Mutation	SNP	A	A	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:166903446A>G	ENST00000423058.2	-	9	1228	c.1211T>C	c.(1210-1212)gTa>gCa	p.V404A	SCN1A_ENST00000375405.3_Missense_Mutation_p.V404A|SCN1A_ENST00000409050.1_Missense_Mutation_p.V404A|AC010127.3_ENST00000595647.1_RNA|AC010127.3_ENST00000595268.1_RNA|AC010127.3_ENST00000599041.1_RNA|SCN1A_ENST00000303395.4_Missense_Mutation_p.V404A	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	404						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	AATGACCAATACAAAAAATAT	0.398000													60	44					0	0	1	0	0
ACTL7A	10881	broad.mit.edu	37	9	111624682	111624682	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:111624682C>T	ENST00000333999.3	+	1	80	c.80C>T	c.(79-81)gCc>gTc	p.A27V		NM_006687.2	NP_006678.1	Q9Y615	ACL7A_HUMAN	actin-like 7A	27						cytoplasm|cytoskeleton|protein complex	structural constituent of cytoskeleton			breast(1)|endometrium(2)|large_intestine(4)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						CAGACACAGGCCCTCCAGACT	0.617000													50	63					0	0	1	0	0
VIM	7431	broad.mit.edu	37	10	17277194	17277194	+	Silent	SNP	T	T	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:17277194T>C	ENST00000544301.1	+	7	1448	c.1035T>C	c.(1033-1035)cgT>cgC	p.R345R	VIM_ENST00000224237.5_Silent_p.R345R	NM_003380.3	NP_003371.2	P08670	VIME_HUMAN	vimentin	345	Coil 2.|Rod.				cellular component disassembly involved in apoptosis|cellular component movement|interspecies interaction between organisms|muscle filament sliding	cytosol|intermediate filament	protein C-terminus binding|structural constituent of cytoskeleton			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(2)|lung(18)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						GCCAGATGCGTGAAATGGAAG	0.483000													17	43					0	0	1	0	0
ZNF141	7700	broad.mit.edu	37	4	367619	367619	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:367619C>A	ENST00000240499.7	+	4	1542	c.1393C>A	c.(1393-1395)Cac>Aac	p.H465N	ZNF141_ENST00000505939.1_Intron|ZNF141_ENST00000512994.1_Intron	NM_003441.2	NP_003432.1	Q15928	ZN141_HUMAN	zinc finger protein 141	465					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			breast(1)|kidney(3)|large_intestine(5)|lung(8)|upper_aerodigestive_tract(1)	18						ACGGTTCTCACACCTGAATAA	0.333000													49	50					1.47857e-17	1.76661e-17	1	1	0
ARHGAP31	57514	broad.mit.edu	37	3	119128361	119128361	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:119128361C>A	ENST00000264245.4	+	11	2196	c.1664C>A	c.(1663-1665)gCa>gAa	p.A555E		NM_020754.2	NP_065805.2	Q2M1Z3	RHG31_HUMAN	Rho GTPase activating protein 31	555					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(3)|large_intestine(11)|lung(29)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	67						CCTAAGAAGGCAGGTCTTGAG	0.517000													14	29					1.05317e-09	1.13767e-09	1	1	0
VGLL4	9686	broad.mit.edu	37	3	11600188	11600188	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:11600188C>G	ENST00000273038.3	-	6	1080	c.715G>C	c.(715-717)Gac>Cac	p.D239H	VGLL4_ENST00000430365.2_Missense_Mutation_p.D245H|VGLL4_ENST00000424529.2_Missense_Mutation_p.D155H|VGLL4_ENST00000451674.2_Missense_Mutation_p.D159H|VGLL4_ENST00000404339.1_Missense_Mutation_p.D244H|VGLL4_ENST00000413604.1_Missense_Mutation_p.D180H	NM_001284391.1|NM_014667.2	NP_001271320.1|NP_055482.2	Q14135	VGLL4_HUMAN	vestigial like 4 (Drosophila)	239					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|endometrium(1)|large_intestine(1)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	10				LUSC - Lung squamous cell carcinoma(1;0.089)|Lung(1;0.111)		GCAAAGTGGTCGTCCACGGAG	0.642000													123	146					0	0	1	0	0
TOP3A	7156	broad.mit.edu	37	17	18181198	18181198	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:18181198C>A	ENST00000321105.5	-	18	2832	c.2618G>T	c.(2617-2619)tGc>tTc	p.C873F	TOP3A_ENST00000540524.1_Missense_Mutation_p.C403F|TOP3A_ENST00000542570.1_Missense_Mutation_p.C778F	NM_004618.3	NP_004609.1	Q13472	TOP3A_HUMAN	topoisomerase (DNA) III alpha	873	2 X 27 AA approximate repeats.				DNA topological change|meiosis	chromosome|PML body	ATP binding|DNA topoisomerase type I activity|protein binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(15)|ovary(1)|skin(6)|stomach(2)|urinary_tract(1)	36						GCCTGGTGGGCATCCCAGGGA	0.642000													57	55					2.14255e-21	2.65177e-21	1	1	0
B4GALT1	2683	broad.mit.edu	37	9	33166812	33166812	+	Missense_Mutation	SNP	A	A	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:33166812A>T	ENST00000379731.4	-	1	542	c.356T>A	c.(355-357)gTg>gAg	p.V119E	B4GALT1_ENST00000535206.1_Missense_Mutation_p.V119E	NM_001497.3	NP_001488.2	P15291	B4GT1_HUMAN	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1	119					oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	basolateral plasma membrane|brush border membrane|desmosome|external side of plasma membrane|extracellular region|glycocalyx|Golgi cisterna membrane|Golgi trans cisterna|integral to membrane	alpha-tubulin binding|beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity|beta-tubulin binding|lactose synthase activity|metal ion binding|N-acetyllactosamine synthase activity|protein binding|protein homodimerization activity			endometrium(1)|large_intestine(7)|lung(4)|prostate(1)|skin(1)	14			LUSC - Lung squamous cell carcinoma(29;0.0084)	GBM - Glioblastoma multiforme(74;0.121)	N-Acetyl-D-glucosamine(DB00141)	GGTGTGGGGCACTGGGACCGA	0.711000													21	33					0	0	1	0	0
ABCC11	85320	broad.mit.edu	37	16	48248887	48248887	+	Missense_Mutation	SNP	G	G	C	rs142830864		TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:48248887G>C	ENST00000394747.1	-	8	1502	c.1153C>G	c.(1153-1155)Ctg>Gtg	p.L385V	ABCC11_ENST00000394748.1_Missense_Mutation_p.L385V|ABCC11_ENST00000356608.2_Missense_Mutation_p.L385V|ABCC11_ENST00000353782.5_Missense_Mutation_p.L385V|ABCC11_ENST00000537808.1_Missense_Mutation_p.L385V	NM_033151.3	NP_149163.2	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 11	385	ABC transmembrane type-1 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(3)|prostate(2)|skin(5)|urinary_tract(2)	83		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				ATACTTGTCAGGCTCTGGACA	0.448000													31	30					0	0	1	0	0
SCFD1	23256	broad.mit.edu	37	14	31119826	31119826	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:31119826C>T	ENST00000458591.2	+	9	952	c.725C>T	c.(724-726)aCa>aTa	p.T242I	SCFD1_ENST00000541123.1_Missense_Mutation_p.T57I|SCFD1_ENST00000544052.2_Missense_Mutation_p.T175I|SCFD1_ENST00000396629.2_Missense_Mutation_p.T150I|SCFD1_ENST00000421551.3_Missense_Mutation_p.T183I	NM_016106.3	NP_057190.2	Q8WVM8	SCFD1_HUMAN	sec1 family domain containing 1	242					post-Golgi vesicle-mediated transport|protein transport|regulation of ER to Golgi vesicle-mediated transport|response to toxin|retrograde vesicle-mediated transport, Golgi to ER|vesicle docking involved in exocytosis	cis-Golgi network|endoplasmic reticulum membrane|Golgi cisterna membrane|Golgi-associated vesicle|plasma membrane	syntaxin-5 binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)	13	Hepatocellular(127;0.0877)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)	GBM - Glioblastoma multiforme(265;0.0181)		AGTCTTTTTACAGGTGATACA	0.289000													23	40					0	0	1	0	0
PIP4K2C	79837	broad.mit.edu	37	12	57989742	57989742	+	Silent	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:57989742G>C	ENST00000354947.5	+	4	457	c.441G>C	c.(439-441)cgG>cgC	p.R147R	PIP4K2C_ENST00000422156.3_Intron|PIP4K2C_ENST00000550465.1_Silent_p.R129R|PIP4K2C_ENST00000540759.2_Silent_p.R147R			Q8TBX8	PI42C_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type II, gamma	147	PIPK.					cytoplasm|membrane	1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding|identical protein binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(13)|pancreas(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	33	Melanoma(17;0.122)					CCTACGATCGGACTCTGGTCA	0.522000													52	85					0	0	1	0	0
CACNA1S	779	broad.mit.edu	37	1	201016656	201016656	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:201016656C>T	ENST00000362061.3	-	37	4766	c.4540G>A	c.(4540-4542)Gga>Aga	p.G1514R	CACNA1S_ENST00000367338.3_Missense_Mutation_p.G1495R	NM_000069.2	NP_000060.2	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type, alpha 1S subunit	1514					axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(19)|lung(37)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	102					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	CACCTACCTCCTATTGGAGGG	0.547000													18	46					0	0	1	0	0
LRFN1	57622	broad.mit.edu	37	19	39804639	39804639	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:39804639C>A	ENST00000248668.4	-	1	1337	c.1338G>T	c.(1336-1338)agG>agT	p.R446S		NM_020862.1	NP_065913.1	Q9P244	LRFN1_HUMAN	leucine rich repeat and fibronectin type III domain containing 1	446	Fibronectin type-III.					cell junction|integral to membrane|postsynaptic density|postsynaptic membrane				central_nervous_system(2)|cervix(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	18	all_cancers(60;1.85e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;1.96e-27)|all cancers(26;2.05e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			CGGGCACAGGCCTCTGGGCTG	0.647000													16	39					2.32078e-09	2.49722e-09	1	1	0
KCNS2	3788	broad.mit.edu	37	8	99441294	99441294	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr8:99441294G>T	ENST00000287042.4	+	2	1437	c.1087G>T	c.(1087-1089)Gcc>Tcc	p.A363S	KCNS2_ENST00000521839.1_Missense_Mutation_p.A363S	NM_020697.2	NP_065748.1	Q9ULS6	KCNS2_HUMAN	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2	363						voltage-gated potassium channel complex	voltage-gated potassium channel activity			autonomic_ganglia(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	31	Breast(36;2.4e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.0448)			CACCATCCCTGCCTGCTGGTG	0.602000													52	51					4.88482e-21	6.0188e-21	1	1	0
BRF2	55290	broad.mit.edu	37	8	37702487	37702487	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr8:37702487G>A	ENST00000220659.6	-	4	901	c.781C>T	c.(781-783)Ccg>Tcg	p.P261S	BRF2_ENST00000520601.1_3'UTR	NM_018310.3	NP_060780.2	Q9HAW0	BRF2_HUMAN	BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit	261					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter|transcription initiation, DNA-dependent	nucleoplasm	protein binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(3)|liver(1)|lung(5)|ovary(1)	12		Lung NSC(58;0.118)|all_lung(54;0.195)	BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;1.81e-10)			GAGGACGCCGGGTAGGGCAGG	0.587000													141	30					0	0	1	0	0
VENTX	27287	broad.mit.edu	37	10	135053570	135053570	+	Silent	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:135053570C>T	ENST00000325980.9	+	3	1048	c.537C>T	c.(535-537)ggC>ggT	p.G179G		NM_014468.3	NP_055283.1	O95231	VENTX_HUMAN	VENT homeobox	179					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(1)|large_intestine(1)|lung(9)|soft_tissue(1)|upper_aerodigestive_tract(1)	14		all_cancers(35;4.15e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;7.8e-06)|Epithelial(32;9.31e-06)|all cancers(32;1.19e-05)		TTGCCAATGGCCTGCAGCTGC	0.647000													22	53					0	0	1	0	0
DCHS2	54798	broad.mit.edu	37	4	155158070	155158070	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:155158070C>A	ENST00000357232.4	-	25	6368	c.6369G>T	c.(6367-6369)tgG>tgT	p.W2123C		NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2		Cadherin 19.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		TTTCACGGGTCCAGTCATGGT	0.378000													58	70					6.3091e-27	8.11801e-27	1	1	0
ANGPT4	51378	broad.mit.edu	37	20	869075	869075	+	Missense_Mutation	SNP	T	T	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:869075T>A	ENST00000381922.3	-	3	575	c.473A>T	c.(472-474)aAc>aTc	p.N158I	ANGPT4_ENST00000546022.1_Missense_Mutation_p.N158I	NM_015985.2	NP_057069.1	Q9Y264	ANGP4_HUMAN	angiopoietin 4	158					anti-apoptosis|blood coagulation|cellular response to hypoxia|leukocyte migration|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of peptidyl-tyrosine phosphorylation|signal transduction	extracellular space	receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)	27						TGATGTCTGGTTCAGGAGCTG	0.602000													16	100					0	0	1	0	0
PIDD	55367	broad.mit.edu	37	11	800619	800619	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:800619C>A	ENST00000347755.5	-	12	2106	c.1965G>T	c.(1963-1965)gaG>gaT	p.E655D	PIDD_ENST00000411829.2_Missense_Mutation_p.E655D	NM_145886.3|NM_145887.3	NP_665893.2|NP_665894.2	Q9HB75	PIDD_HUMAN	p53-induced death domain protein	655					apoptosis|signal transduction	cytoplasm|nucleus	death receptor binding										TGTCAGAGGGCTCGGGGCCCC	0.677000													17	1					4.75885e-15	5.49557e-15	1	1	0
MTA2	9219	broad.mit.edu	37	11	62363785	62363785	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:62363785C>G	ENST00000278823.2	-	11	1371	c.982G>C	c.(982-984)Gac>Cac	p.D328H	MTA2_ENST00000524902.1_Missense_Mutation_p.D155H|MTA2_ENST00000527204.1_Missense_Mutation_p.D155H	NM_004739.3	NP_004730.2	O94776	MTA2_HUMAN	metastasis associated 1 family, member 2	328					chromatin assembly or disassembly	NuRD complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	26						AGTTTGCTGTCTGCTTCAGCA	0.468000													21	23					0	0	1	0	0
OPRK1	4986	broad.mit.edu	37	8	54142079	54142079	+	Silent	SNP	A	A	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr8:54142079A>G	ENST00000265572.3	-	4	1218	c.921T>C	c.(919-921)gcT>gcC	p.A307A	OPRK1_ENST00000524278.1_Silent_p.A218A|RP11-162D9.3_ENST00000524425.1_RNA|OPRK1_ENST00000520287.1_Silent_p.A307A	NM_000912.3	NP_000903.2	P41145	OPRK_HUMAN	opioid receptor, kappa 1	307					behavior|immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception|synaptic transmission|viral genome replication	integral to plasma membrane	kappa-opioid receptor activity|protein binding			NS(2)|breast(3)|endometrium(3)|kidney(12)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(5)|urinary_tract(1)	43		all_epithelial(80;0.066)|Lung NSC(129;0.0804)|all_lung(136;0.136)			Buprenorphine(DB00921)|Butorphanol(DB00611)|Cocaine(DB00907)|Codeine(DB00318)|Dezocine(DB01209)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Meperidine(DB00454)|Mirtazapine(DB00370)|Morphine(DB00295)|Nalbuphine(DB00844)|Naltrexone(DB00704)|Oxycodone(DB00497)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Tramadol(DB00193)	TGGAGAGAGCAGCTGTGCTGT	0.527000													27	28					0	0	1	0	0
MIOS	54468	broad.mit.edu	37	7	7636000	7636000	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:7636000C>A	ENST00000340080.4	+	11	2730	c.2309C>A	c.(2308-2310)tCt>tAt	p.S770Y	MIOS_ENST00000405785.1_Missense_Mutation_p.S770Y	NM_019005.3	NP_061878.3	Q9NXC5	MIO_HUMAN	missing oocyte, meiosis regulator, homolog (Drosophila)	770										breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(15)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						CCAACGAAATCTAAAGTCACA	0.468000													16	134					1.52009e-12	1.70894e-12	1	1	0
PRPH2	5961	broad.mit.edu	37	6	42689673	42689673	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:42689673G>T	ENST00000230381.5	-	1	639	c.400C>A	c.(400-402)Ctc>Atc	p.L134I		NM_000322.4	NP_000313.2	P23942	PRPH2_HUMAN	peripherin 2 (retinal degeneration, slow)	134					cell adhesion|visual perception	integral to membrane				NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(1)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	18	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.00178)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.0904)			CCGTTCTTGAGCCCTTGGCCC	0.542000													33	43					1.30293e-26	1.6726e-26	1	1	0
MUC16	94025	broad.mit.edu	37	19	9058002	9058002	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:9058002G>T	ENST00000397910.4	-	3	29647	c.29444C>A	c.(29443-29445)gCc>gAc	p.A9815D		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9817	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CCTCACTTTGGCCACCGCTGT	0.458000													73	138					1.08321e-29	1.44079e-29	1	1	0
NBEAP1	606	broad.mit.edu	37	15	20876539	20876539	+	RNA	SNP	T	T	A	rs146180697	by1000genomes	TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr15:20876539T>A	ENST00000556948.1	-	0	61																											ACCATCAAGGTATTTTGCAAA	0.348000													9	75					0	0	1	0	0
DSCAML1	57453	broad.mit.edu	37	11	117301499	117301499	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:117301499C>A	ENST00000321322.6	-	32	5806	c.5805G>T	c.(5803-5805)aaG>aaT	p.K1935N	DSCAML1_ENST00000527706.1_Missense_Mutation_p.K1665N	NM_020693.2	NP_065744.2	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1875					axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(24)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	110	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		CATCCTGGGGCTTGGGTGGTG	0.637000													93	126					1.59228e-47	2.23081e-47	1	1	0
DSC1	1823	broad.mit.edu	37	18	28720107	28720107	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr18:28720107G>A	ENST00000257197.3	-	10	1679	c.1418C>T	c.(1417-1419)cCt>cTt	p.P473L	RP11-408H20.2_ENST00000581836.1_RNA|DSC1_ENST00000257198.5_Missense_Mutation_p.P473L	NM_004948.3	NP_004939.1	Q08554	DSC1_HUMAN	desmocollin 1	473	Cadherin 4.				homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(20)|ovary(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			TTTCACTGGAGGGTGGCATTC	0.473000													52	61					0	0	1	0	0
APLP1	333	broad.mit.edu	37	19	36365745	36365745	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:36365745G>A	ENST00000221891.4	+	10	1510	c.1318G>A	c.(1318-1320)Gag>Aag	p.E440K	APLP1_ENST00000589298.2_3'UTR|APLP1_ENST00000537454.2_Missense_Mutation_p.E401K|APLP1_ENST00000586861.1_Missense_Mutation_p.E434K	NM_001024807.1|NM_005166.3	NP_001019978.1|NP_005157.1	P51693	APLP1_HUMAN	amyloid beta (A4) precursor-like protein 1	440	Heparin-binding (By similarity).				apoptosis|cell adhesion|cellular response to norepinephrine stimulus|endocytosis|negative regulation of cAMP biosynthetic process|nervous system development|organ morphogenesis	basement membrane|integral to membrane|perinuclear region of cytoplasm|plasma membrane	alpha-2A adrenergic receptor binding|alpha-2B adrenergic receptor binding|alpha-2C adrenergic receptor binding|heparin binding|identical protein binding|metal ion binding			breast(4)|endometrium(2)|kidney(2)|large_intestine(12)|liver(1)|lung(9)|ovary(2)|upper_aerodigestive_tract(1)	33	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CGTGGATCCCGAGAAGGCACA	0.642000													25	26					0	0	1	0	0
USP24	23358	broad.mit.edu	37	1	55549036	55549036	+	Splice_Site	SNP	T	T	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:55549036T>G	ENST00000294383.6	-	58	6883	c.6884A>C	c.(6883-6885)cAa>cCa	p.Q2295P	USP24_ENST00000407756.1_Splice_Site_p.Q2135P	NM_015306.2	NP_056121.2	Q9UPU5	UBP24_HUMAN	ubiquitin specific peptidase 24	2295					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(4)|cervix(1)|endometrium(8)|kidney(13)|large_intestine(7)|lung(16)|ovary(6)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	60						CCTAATTCCTTGCTGTCACAA	0.393000													26	6					0	0	1	0	0
ZNF846	162993	broad.mit.edu	37	19	9868990	9868990	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:9868990C>T	ENST00000397902.2	-	6	1176	c.763G>A	c.(763-765)Gtc>Atc	p.V255I	ZNF846_ENST00000586293.1_3'UTR|ZNF846_ENST00000592859.1_Missense_Mutation_p.V126I|ZNF846_ENST00000588267.1_Missense_Mutation_p.V126I	NM_001077624.1	NP_001071092.1	Q147U1	ZN846_HUMAN	zinc finger protein 846	255					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	22						TCTTTACAGACATAGGGCTTC	0.393000													47	107					0	0	1	0	0
MUC3A	4584	broad.mit.edu	37	7	100610083	100610083	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:100610083G>A	ENST00000319509.7	+	10	2568	c.2568G>A	c.(2566-2568)gaG>gaA	p.E856E	RP11-395B7.2_ENST00000420080.1_RNA					mucin 3A, cell surface associated											breast(3)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(1)|lung(32)|prostate(3)	44						TGGCCTTGGAGAACGTGGACA	0.577000													25	125					0	0	1	0	0
RCOR3	55758	broad.mit.edu	37	1	211462527	211462527	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:211462527C>T	ENST00000367005.4	+	7	695	c.554C>T	c.(553-555)aCt>aTt	p.T185I	RCOR3_ENST00000367006.4_Missense_Mutation_p.T243I|RCOR3_ENST00000452621.2_Missense_Mutation_p.T243I|RCOR3_ENST00000419091.2_Missense_Mutation_p.T243I	NM_018254.3	NP_060724.1	Q9P2K3	RCOR3_HUMAN	REST corepressor 3	185					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(6)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	21				OV - Ovarian serous cystadenocarcinoma(81;0.00961)|all cancers(67;0.0999)|Epithelial(68;0.171)		TAGGGTAATACTGAACAACCT	0.378000													47	71					0	0	1	0	0
SPATA31D1	389763	broad.mit.edu	37	9	84607839	84607839	+	Silent	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:84607839G>T	ENST00000344803.2	+	4	2501	c.2454G>T	c.(2452-2454)ggG>ggT	p.G818G		NM_001001670.2	NP_001001670.1			SPATA31 subfamily D, member 1																		ATGACTCAGGGGTGAGACTAG	0.458000													37	60					1.47244e-24	1.8642e-24	1	1	0
TRIM59	286827	broad.mit.edu	37	3	160156689	160156689	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:160156689C>A	ENST00000543469.1	-	2	497	c.283G>T	c.(283-285)Gtc>Ttc	p.V95F	RP11-432B6.3_ENST00000483754.1_Missense_Mutation_p.V95F|TRIM59_ENST00000309784.4_Missense_Mutation_p.V95F			Q8IWR1	TRI59_HUMAN	tripartite motif containing 59	95						integral to membrane|intracellular	zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|urinary_tract(3)	15			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			GGGCAGGTGACAATATCTGGA	0.363000													39	58					1.47244e-24	1.8642e-24	1	1	0
CELSR3	1951	broad.mit.edu	37	3	48684347	48684347	+	Missense_Mutation	SNP	T	T	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:48684347T>C	ENST00000544264.1	-	22	7439	c.7159A>G	c.(7159-7161)Agc>Ggc	p.S2387G	CELSR3_ENST00000164024.4_Missense_Mutation_p.S2382G			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	2382					homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		TCTATGCTGCTGCTTGTGGGC	0.572000													9	2					0	0	1	0	0
TEX35	84066	broad.mit.edu	37	1	178483197	178483197	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:178483197G>A	ENST00000367642.3	+	2	146	c.75G>A	c.(73-75)aaG>aaA	p.K25K	TEX35_ENST00000367643.3_Silent_p.K25K|TEX35_ENST00000367639.1_Silent_p.K33K|TEX35_ENST00000319416.2_Silent_p.K25K|TEX35_ENST00000367641.3_Silent_p.K25K|TEX35_ENST00000258298.2_5'UTR					testis expressed 35																		TGGAATTGAAGCCAGAGCCGA	0.532000													35	78					0	0	1	0	0
PAPSS2	9060	broad.mit.edu	37	10	89472929	89472929	+	Silent	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:89472929C>G	ENST00000361175.4	+	3	612	c.243C>G	c.(241-243)gtC>gtG	p.V81V	PAPSS2_ENST00000427144.2_Silent_p.V85V|PAPSS2_ENST00000482258.1_3'UTR|PAPSS2_ENST00000456849.1_Silent_p.V81V	NM_004670.3	NP_004661.2	O95340	PAPS2_HUMAN	3'-phosphoadenosine 5'-phosphosulfate synthase 2	81					3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|skeletal system development|sulfate assimilation|xenobiotic metabolic process	cytosol	adenylylsulfate kinase activity|ATP binding|protein binding|sulfate adenylyltransferase (ATP) activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|skin(1)|stomach(1)	20		Melanoma(5;0.019)|Colorectal(252;0.123)		UCEC - Uterine corpus endometrioid carcinoma (6;0.00164)|Colorectal(12;0.000323)|COAD - Colon adenocarcinoma(12;0.00124)		GGGACAATGTCCGTCATGGCC	0.517000													77	51					0	0	1	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54911366	54911366	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:54911366G>T	ENST00000293373.6	+	12	1224	c.1145G>T	c.(1144-1146)tGg>tTg	p.W382L	NCKAP1L_ENST00000545638.2_Missense_Mutation_p.W332L	NM_005337.4	NP_005328.2	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	382					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(37)|ovary(3)|prostate(3)|skin(3)|stomach(2)	80						GAGGTCACCTGGCTGGTTCGC	0.448000													42	43					3.86236e-30	5.14981e-30	1	1	0
OR10A6	390093	broad.mit.edu	37	11	7949365	7949365	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:7949365G>T	ENST00000309838.2	-	1	844	c.845C>A	c.(844-846)aCa>aAa	p.T282K		NM_001004461.1	NP_001004461.1	Q8NH74	O10A6_HUMAN	olfactory receptor, family 10, subfamily A, member 6	282					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(5)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	22				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CAGCAGTGGTGTCAGAAGTGA	0.423000													49	8					4.25531e-23	5.31433e-23	1	1	0
CEACAM4	1089	broad.mit.edu	37	19	42132180	42132180	+	Silent	SNP	T	T	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:42132180T>A	ENST00000221954.2	-	2	329	c.219A>T	c.(217-219)gcA>gcT	p.A73A	CEACAM4_ENST00000600925.1_Silent_p.A73A	NM_001817.2	NP_001808.2	O75871	CEAM4_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 4	73	Ig-like V-type.					integral to plasma membrane|membrane fraction				NS(1)|endometrium(1)|large_intestine(3)|lung(4)|prostate(3)|skin(3)|urinary_tract(1)	16						GGCTCCCTTCTGCCGTTTTCC	0.493000													87	54					0	0	1	0	0
DPP4	1803	broad.mit.edu	37	2	162865119	162865119	+	Missense_Mutation	SNP	A	A	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:162865119A>G	ENST00000360534.3	-	22	2500	c.1940T>C	c.(1939-1941)tTc>tCc	p.F647S	DPP4_ENST00000491591.1_5'UTR	NM_001935.3	NP_001926.2	P27487	DPP4_HUMAN	dipeptidyl-peptidase 4	647					cell adhesion|endothelial cell migration|negative regulation of extracellular matrix disassembly|positive regulation of cell proliferation|proteolysis|regulation of cell-cell adhesion mediated by integrin|response to hypoxia|T cell activation|T cell costimulation	apical plasma membrane|cell surface|endocytic vesicle|extracellular region|integral to membrane|invadopodium membrane|lamellipodium membrane|membrane raft	aminopeptidase activity|dipeptidyl-peptidase activity|protease binding|protein homodimerization activity|receptor activity|receptor binding|serine-type endopeptidase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(21)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	48					Sitagliptin(DB01261)	TCCACACTTGAACACGCCACT	0.463000													45	51					0	0	1	0	0
LRCH1	23143	broad.mit.edu	37	13	47243194	47243194	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr13:47243194G>C	ENST00000311191.6	+	3	711	c.482G>C	c.(481-483)tGc>tCc	p.C161S	LRCH1_ENST00000389798.3_Missense_Mutation_p.C161S|LRCH1_ENST00000389797.3_Missense_Mutation_p.C161S	NM_001164213.1	NP_001157685	Q9Y2L9	LRCH1_HUMAN	leucine-rich repeats and calponin homology (CH) domain containing 1	161								p.C161>?(1)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26		all_lung(13;5.61e-07)|Lung NSC(96;0.000117)|Breast(56;0.000141)|Prostate(109;0.0029)|Lung SC(185;0.0367)|Myeloproliferative disorder(33;0.0505)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000123)		CTGCCTGCCTGCCTGTGTGGT	0.443000													82	107					0	0	1	0	0
MAPK8IP2	23542	broad.mit.edu	37	22	51044009	51044009	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr22:51044009G>T	ENST00000399908.2	+	5	1779	c.1063G>T	c.(1063-1065)Gac>Tac	p.D355Y	MAPK8IP2_ENST00000329492.3_Missense_Mutation_p.D620Y|MAPK8IP2_ENST00000341339.4_Missense_Mutation_p.D241Y|MAPK8IP2_ENST00000008876.5_Missense_Mutation_p.D326Y|MAPK8IP2_ENST00000399912.1_Missense_Mutation_p.D355Y|MAPK8IP2_ENST00000442429.2_Missense_Mutation_p.D343Y	NM_016431.3	NP_057515.1	Q13387	JIP2_HUMAN	mitogen-activated protein kinase 8 interacting protein 2	621					behavioral fear response|dendrite morphogenesis|MAPKKK cascade|nonassociative learning|positive regulation of anti-apoptosis|regulation of excitatory postsynaptic membrane potential|regulation of JNK cascade|regulation of receptor activity|regulation of synaptic transmission, glutamatergic|signal complex assembly|social behavior	cytoplasm|postsynaptic density	beta-amyloid binding|kinesin binding|MAP-kinase scaffold activity|protein kinase activator activity|protein kinase binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)	7		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		OV - Ovarian serous cystadenocarcinoma(4;1.28e-70)|Epithelial(4;3.46e-65)|GBM - Glioblastoma multiforme(4;4.83e-06)|Lung(4;0.125)|BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GCGGCATCCAGACGAGCTGGA	0.652000													7	9					0.00198382	0.00200195	1	1	0
NOL6	65083	broad.mit.edu	37	9	33468850	33468850	+	Silent	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:33468850C>A	ENST00000379471.2	-	8	1134	c.1047G>T	c.(1045-1047)ggG>ggT	p.G349G	NOL6_ENST00000464829.1_5'UTR|NOL6_ENST00000455041.2_Silent_p.G289G			Q9H6R4	NOL6_HUMAN	nucleolar protein 6 (RNA-associated)	349					rRNA processing	condensed nuclear chromosome|nucleolus	RNA binding			endometrium(4)|kidney(4)|large_intestine(5)|lung(8)|ovary(2)|prostate(2)|skin(2)	27			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.152)		AGACAAGGAACCCAGTAAACC	0.572000													95	138					1.1777e-47	1.65839e-47	1	1	0
NRBF2	29982	broad.mit.edu	37	10	64913495	64913495	+	Silent	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:64913495G>T	ENST00000277746.6	+	4	562	c.381G>T	c.(379-381)ctG>ctT	p.L127L	NRBF2_ENST00000435510.2_Silent_p.L117L	NM_030759.3	NP_110386.2	Q96F24	NRBF2_HUMAN	nuclear receptor binding factor 2	127					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	cytoplasm|nucleoplasm	protein binding			large_intestine(2)|lung(3)|skin(1)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)					AGAAATGCCTGCCTGAGATTC	0.507000													12	25					1.61879e-10	1.76595e-10	1	1	0
SMO	6608	broad.mit.edu	37	7	128850354	128850354	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:128850354G>A	ENST00000249373.3	+	9	1897	c.1617G>A	c.(1615-1617)aaG>aaA	p.K539K	RP11-286H14.8_ENST00000466717.1_RNA	NM_005631.4	NP_005622.1	Q99835	SMO_HUMAN	smoothened, frizzled family receptor	539					adenohypophysis development|axon extension involved in axon guidance|canonical Wnt receptor signaling pathway|cardioblast differentiation|central nervous system neuron differentiation|cerebellar cortex morphogenesis|ciliary receptor clustering involved in smoothened signaling pathway|determination of left/right symmetry|dorsal/ventral neural tube patterning|embryonic camera-type eye development|embryonic digestive tract morphogenesis|embryonic neurocranium morphogenesis|embryonic viscerocranium morphogenesis|exocrine pancreas development|facial nerve development|floor plate formation|gonad development|heart morphogenesis|muscle cell fate commitment|negative regulation of apoptosis|neural crest cell migration|neuron fate commitment|neuron projection regeneration|odontogenesis of dentine-containing tooth|osteoblast differentiation|otolith morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of neuroblast proliferation|positive regulation of smoothened signaling pathway|semicircular canal morphogenesis|smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation|smoothened signaling pathway involved in ventral spinal cord patterning|spermatogenesis|vasculogenesis	cilium|cytoplasm|integral to membrane|neuronal cell body|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			biliary_tract(1)|central_nervous_system(5)|endometrium(1)|kidney(4)|large_intestine(14)|liver(1)|lung(11)|pancreas(2)|prostate(1)|skin(20)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						TCTGGACCAAGGCCACGCTGC	0.607000			Mis		skin basal cell						OREG0018305	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	47	71					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38649641	38649641	+	Splice_Site	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:38649641C>T	ENST00000413689.1	-	8	1192		c.e8+1		SCN5A_ENST00000450102.2_Splice_Site|SCN5A_ENST00000414099.2_Splice_Site|SCN5A_ENST00000443581.1_Splice_Site|SCN5A_ENST00000423572.2_Splice_Site|SCN5A_ENST00000455624.2_Splice_Site|SCN5A_ENST00000333535.4_Splice_Site|SCN5A_ENST00000449557.2_Splice_Site|SCN5A_ENST00000425664.1_Splice_Site|SCN5A_ENST00000451551.2_Splice_Site	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit						blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	GTGCCACATACCCAGCGTCAG	0.522000													228	129					0	0	1	0	0
RNF215	200312	broad.mit.edu	37	22	30780398	30780398	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr22:30780398C>T	ENST00000382363.3	-	5	748	c.674G>A	c.(673-675)gGc>gAc	p.G225D		NM_001017981.1	NP_001017981.1	Q9Y6U7	RN215_HUMAN	ring finger protein 215	225						integral to membrane	zinc ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(2)	6						CTTGGAGAGGCCACAGGTGGT	0.602000													42	45					0	0	1	0	0
SLAMF8	56833	broad.mit.edu	37	1	159802972	159802972	+	Splice_Site	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:159802972G>A	ENST00000289707.5	+	3	822		c.e3+1		SLAMF8_ENST00000368104.4_Splice_Site|SLAMF8_ENST00000471286.1_Splice_Site	NM_020125.2	NP_064510.1	Q9P0V8	SLAF8_HUMAN	SLAM family member 8							integral to membrane				endometrium(2)|large_intestine(4)|lung(6)	12	all_hematologic(112;0.0597)					CATGAGGCAGGTATGCTAAGG	0.562000													105	62					0	0	1	0	0
MAGEB18	286514	broad.mit.edu	37	X	26157994	26157994	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chrX:26157994G>T	ENST00000325250.1	+	2	1079	c.892G>T	c.(892-894)Gcc>Tcc	p.A298S		NM_173699.3	NP_775970	Q96M61	MAGBI_HUMAN	melanoma antigen family B, 18	298	MAGE.						protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(17)|skin(2)|stomach(1)|urinary_tract(2)	33						CGTCCCTAGTGCCTTCCCATC	0.522000													12	1					5.16669e-11	5.6813e-11	1	1	0
STAG3L4	64940	broad.mit.edu	37	7	66767776	66767776	+	RNA	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:66767776C>T	ENST00000416602.2	+	0	169					NR_040586.1		Q8TBR4	STG34_HUMAN												endometrium(2)|lung(5)	7		Lung NSC(55;0.0839)|all_lung(88;0.181)				ACGGGCGCGGCGCGCCTCTCC	0.637000													14	24					0	0	1	0	0
DUSP13	51207	broad.mit.edu	37	10	76867962	76867962	+	Translation_Start_Site	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:76867962G>A	ENST00000491677.2	-	0	209				DUSP13_ENST00000607131.1_Intron|DUSP13_ENST00000372702.3_Missense_Mutation_p.T52M|DUSP13_ENST00000372700.3_Intron|DUSP13_ENST00000607009.1_5'UTR	NM_001007271.1	NP_001007272.1	Q6B8I1	MDSP_HUMAN	dual specificity phosphatase 13							cytoplasm	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			large_intestine(3)|lung(3)|prostate(1)|urinary_tract(1)	8	all_cancers(46;0.0207)|all_epithelial(25;0.00126)|Prostate(51;0.0112)|Ovarian(15;0.0348)					GTTGTTTGCCGTGGCCCTGGG	0.662000													21	39					0	0	1	0	0
DLGAP2	9228	broad.mit.edu	37	8	1497669	1497669	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr8:1497669G>C	ENST00000421627.2	+	2	944	c.810G>C	c.(808-810)aaG>aaC	p.K270N		NM_004745.3	NP_004736.2	Q9P1A6	DLGP2_HUMAN	discs, large (Drosophila) homolog-associated protein 2	349					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding			breast(1)|endometrium(6)|lung(31)|prostate(3)	41		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		ACGACGTCAAGTGCTCGGCCT	0.672000													65	7					0	0	1	0	0
TMPRSS2	7113	broad.mit.edu	37	21	42845396	42845396	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr21:42845396C>A	ENST00000398585.3	-	9	926	c.866G>T	c.(865-867)cGc>cTc	p.R289L	TMPRSS2_ENST00000332149.5_Missense_Mutation_p.R252L|TMPRSS2_ENST00000458356.1_Missense_Mutation_p.R252L	NM_001135099.1	NP_001128571.1	O15393	TMPS2_HUMAN	transmembrane protease, serine 2	252	Peptidase S1.				proteolysis	cytoplasm|extracellular region|integral to plasma membrane	scavenger receptor activity|serine-type endopeptidase activity		TMPRSS2/ETV1(34)|TMPRSS2/ETV5_ENST00000306376(5)|TMPRSS2/ERG(3582)|TMPRSS2/ETV4(13)	central_nervous_system(1)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	4		Prostate(19;4.48e-07)|all_epithelial(19;0.031)				CCTGCTCTGGCGGCTTGAGTT	0.687000			T	"""ERG, ETV1, ETV4, ETV5"""	prostate								5	12					3.45872e-05	3.54214e-05	1	1	0
OTUD6A	139562	broad.mit.edu	37	X	69282757	69282757	+	Missense_Mutation	SNP	A	A	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chrX:69282757A>T	ENST00000338352.2	+	1	417	c.383A>T	c.(382-384)gAg>gTg	p.E128V		NM_207320.1	NP_997203.1	Q7L8S5	OTU6A_HUMAN	OTU domain containing 6A	128										autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(8)|skin(3)|urinary_tract(1)	23						AAGCGCGAGGAGGAGGAGAAG	0.627000													6	1					0	0	1	0	0
MYO1F	4542	broad.mit.edu	37	19	8609325	8609325	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:8609325G>A	ENST00000338257.8	-	14	1647	c.1380C>T	c.(1378-1380)gtC>gtT	p.V460V		NM_012335.3	NP_036467.2	O00160	MYO1F_HUMAN	myosin IF	460	Myosin head-like.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(7)|lung(13)|ovary(3)|prostate(3)|skin(3)|urinary_tract(1)	42						CGTCGTCCAAGACGCTCATGA	0.657000													35	115					0	0	1	0	0
IGHV3-43	28426	broad.mit.edu	37	14	106926316	106926316	+	RNA	SNP	T	T	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:106926316T>A	ENST00000434710.1	-	0	305																											TAGTATGTGCTACCACCATCC	0.493000													329	163					0	0	1	0	0
NANOS3	342977	broad.mit.edu	37	19	13988397	13988397	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:13988397G>A	ENST00000397555.2	+	2	278	c.278G>A	c.(277-279)tGt>tAt	p.C93Y	NANOS3_ENST00000591727.1_Intron|NANOS3_ENST00000339133.5_Missense_Mutation_p.C112Y	NM_001098622.2	NP_001092092.1	P60323	NANO3_HUMAN	nanos homolog 3 (Drosophila)	93					anti-apoptosis|germ cell development|multicellular organismal development|oogenesis|regulation of cell cycle|regulation of translation|spermatogenesis	cytoplasmic mRNA processing body|nucleus|stress granule	RNA binding|zinc ion binding			breast(1)|lung(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	7			OV - Ovarian serous cystadenocarcinoma(19;2e-21)			GACTACGTGTGTCCCCAGTGC	0.647000													30	27					0	0	1	0	0
CERKL	375298	broad.mit.edu	37	2	182403985	182403985	+	Missense_Mutation	SNP	A	A	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:182403985A>T	ENST00000410087.3	-	12	1472	c.1372T>A	c.(1372-1374)Ttt>Att	p.F458I	CERKL_ENST00000374970.2_Missense_Mutation_p.F389I|CERKL_ENST00000374969.2_Missense_Mutation_p.F345I|CERKL_ENST00000409440.3_Missense_Mutation_p.F440I|CERKL_ENST00000339098.5_Missense_Mutation_p.F484I	NM_001030311.2|NM_201548.4	NP_001025482.1|NP_963842.1	Q49MI3	CERKL_HUMAN	ceramide kinase-like	484					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis	endoplasmic reticulum|Golgi apparatus|nucleolus	diacylglycerol kinase activity			NS(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(13)|ovary(3)|skin(3)	32			OV - Ovarian serous cystadenocarcinoma(117;0.088)			ACAAATGGAAAATTGAACTAA	0.353000													26	29					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149482090	149482090	+	RNA	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:149482090G>A	ENST00000378016.2	+	0	2878							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CTGTCCACCAGGCACGGTGCT	0.627000													22	17					0	0	1	0	0
ST8SIA3	51046	broad.mit.edu	37	18	55024154	55024154	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr18:55024154C>A	ENST00000324000.3	+	3	2347	c.313C>A	c.(313-315)Ctt>Att	p.L105I		NM_015879.2	NP_056963.2	O43173	SIA8C_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3	105					glycosphingolipid biosynthetic process|N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity	p.L105I(1)		breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(16)|prostate(1)|skin(3)	36				READ - Rectum adenocarcinoma(59;0.19)|Colorectal(16;0.205)		GCAAGAAATTCTTCAGCATGT	0.318000													24	21					5.35047e-06	5.53082e-06	1	1	0
FGFR3	2261	broad.mit.edu	37	4	1803564	1803564	+	Missense_Mutation	SNP	C	C	T	rs121913482		TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:1803564C>T	ENST00000340107.4	+	7	998	c.742C>T	c.(742-744)Cgc>Tgc	p.R248C	FGFR3_ENST00000260795.2_Missense_Mutation_p.R248C|FGFR3_ENST00000440486.2_Missense_Mutation_p.R248C|FGFR3_ENST00000481110.2_Missense_Mutation_p.R248C|FGFR3_ENST00000412135.2_Missense_Mutation_p.R248C|FGFR3_ENST00000474521.1_3'UTR|FGFR3_ENST00000352904.1_Missense_Mutation_p.R248C	NM_001163213.1	NP_001156685.1	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3	248			R -> C (in KERSEB, bladder cancer, keratinocytic non-epidermolytic nevus and TD1; severe and lethal; also found as somatic mutation in one patient with multiple myeloma).		bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding	p.R248C(241)|p.R248_S249del(1)|p.R248_S249insC(1)		NS(1)|central_nervous_system(5)|cervix(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(40)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(9)|skin(339)|soft_tissue(4)|testis(2)|upper_aerodigestive_tract(58)|urinary_tract(2607)	3091		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	CCCCACAGAGCGCTCCCCGCA	0.741000		1	"""Mis, T"""	"""IGH@, ETV6"""	"""bladder, MM, T-cell lymphoma"""		"""Hypochondroplasia, Thanatophoric dysplasia"""		Saethre-Chotzen syndrome;Muenke syndrome				6	37					0	0	1	0	0
SPEF2	79925	broad.mit.edu	37	5	35700720	35700720	+	Missense_Mutation	SNP	A	A	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:35700720A>C	ENST00000440995.2	+	16	2249	c.2249A>C	c.(2248-2250)aAa>aCa	p.K750T	SPEF2_ENST00000509059.1_Missense_Mutation_p.K750T|SPEF2_ENST00000356031.3_Missense_Mutation_p.K755T|CTD-2113L7.1_ENST00000510433.1_RNA			Q9C093	SPEF2_HUMAN	sperm flagellar 2	755					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	37	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GAAAGAAAAAAAGCACAAAAA	0.383000													12	38					0	0	1	0	0
OR52N4	390072	broad.mit.edu	37	11	5775984	5775984	+	Missense_Mutation	SNP	A	A	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:5775984A>C	ENST00000317254.3	+	1	62	c.14A>C	c.(13-15)aAt>aCt	p.N5T	TRIM5_ENST00000380027.1_Intron	NM_001005175.2	NP_001005175.3	Q8NGI2	O52N4_HUMAN	olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene)	5					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;1.87e-10)|LUSC - Lung squamous cell carcinoma(625;0.114)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.197)		CTAACACTGAATAAAACAGAC	0.358000													29	1					0	0	1	0	0
ZCCHC6	79670	broad.mit.edu	37	9	88961372	88961372	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:88961372G>T	ENST00000375961.2	-	3	758	c.544C>A	c.(544-546)Cct>Act	p.P182T	ZCCHC6_ENST00000375963.3_Missense_Mutation_p.P182T|ZCCHC6_ENST00000375960.2_Missense_Mutation_p.P182T|ZCCHC6_ENST00000375947.1_Missense_Mutation_p.P15T|ZCCHC6_ENST00000277141.6_5'UTR			Q5VYS8	TUT7_HUMAN	zinc finger, CCHC domain containing 6	182					RNA 3'-end processing		nucleic acid binding|RNA uridylyltransferase activity|zinc ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	46						GGCTTCCTAGGTCTGGACCTC	0.428000													55	85					7.50695e-29	9.91349e-29	1	1	0
RCCD1	91433	broad.mit.edu	37	15	91500713	91500713	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr15:91500713G>A	ENST00000394258.2	+	3	739	c.537G>A	c.(535-537)gtG>gtA	p.V179V	RCCD1_ENST00000555155.1_Silent_p.V179V|RCCD1_ENST00000556774.1_Intron|RCCD1_ENST00000556618.1_Silent_p.V179V	NM_001017919.1|NM_033544.2	NP_001017919.1|NP_291022.2	A6NED2	RCCD1_HUMAN	RCC1 domain containing 1	179				RLPLLPCARAYVSPRAPFYRPLAPELRARQLELGAEHALLL DAAGQVFSWGGGR -> GGAAGGLVRLRFLRLRAGAGLRTR APGAQPQSAAGGRRHLPRERELELHRFRDP (in Ref. 3; AAI13827).						breast(1)|kidney(1)|large_intestine(2)	4	Lung NSC(78;0.0987)|all_lung(78;0.175)		Lung(145;0.189)			CTGGCCAGGTGTTCTCCTGGG	0.706000													3	5					0	0	1	0	0
RANBP9	10048	broad.mit.edu	37	6	13644837	13644837	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:13644837G>A	ENST00000011619.3	-	6	1110	c.1052C>T	c.(1051-1053)gCa>gTa	p.A351V	RANBP9_ENST00000539980.1_Missense_Mutation_p.A122V	NM_005493.2	NP_005484.2	Q96S59	RANB9_HUMAN	RAN binding protein 9	351					axon guidance|microtubule nucleation|protein complex assembly	cytosol|microtubule associated complex|nucleus	Ran GTPase binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|skin(1)	16	Breast(50;0.00669)|Ovarian(93;0.0634)	all_hematologic(90;0.117)	Epithelial(50;0.223)			ATCTATCTGTGCCTGGATTTT	0.413000													73	90					0	0	1	0	0
CCDC180	100499483	broad.mit.edu	37	9	100124558	100124558	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:100124558C>A	ENST00000375202.2	+	42	5221	c.3869C>A	c.(3868-3870)tCt>tAt	p.S1290Y	CCDC180_ENST00000395220.1_Intron|CCDC180_ENST00000357054.1_Intron|RP11-23J9.4_ENST00000534123.1_RNA|CCDC180_ENST00000529487.1_Missense_Mutation_p.S1290Y					coiled-coil domain containing 180																		GCCTGTGGGTCTCGGGGCAGC	0.587000													91	100					2.33925e-33	3.15713e-33	1	1	0
OTUD7A	161725	broad.mit.edu	37	15	31776332	31776332	+	Missense_Mutation	SNP	A	A	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr15:31776332A>G	ENST00000382902.1	-	11	2059	c.1967T>C	c.(1966-1968)tTc>tCc	p.F656S	OTUD7A_ENST00000307050.4_Missense_Mutation_p.F649S			Q8TE49	OTU7A_HUMAN	OTU domain containing 7A	649						cytoplasm|nucleus	cysteine-type peptidase activity|DNA binding|zinc ion binding			endometrium(7)|large_intestine(4)|lung(11)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	30		all_lung(180;1.6e-09)		all cancers(64;2.44e-19)|Epithelial(43;6.82e-14)|GBM - Glioblastoma multiforme(186;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00189)|Lung(196;0.208)		CTCCTCGTGGAACTGGTGCCG	0.682000													17	32					0	0	1	0	0
SEC24C	9632	broad.mit.edu	37	10	75523669	75523669	+	Silent	SNP	T	T	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:75523669T>A	ENST00000339365.2	+	9	1317	c.1155T>A	c.(1153-1155)tcT>tcA	p.S385S	SEC24C_ENST00000345254.4_Silent_p.S385S|SEC24C_ENST00000540668.1_Intron|SEC24C_ENST00000546025.1_Intron|SEC24C_ENST00000535742.1_Intron|SEC24C_ENST00000411652.2_Silent_p.S266S	NM_004922.3	NP_004913.2	P53992	SC24C_HUMAN	SEC24 family member C	385					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(3)|lung(12)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	32	Prostate(51;0.0112)					CTTGCACATCTGACATGGCTA	0.542000													17	9					0	0	1	0	0
P4HB	5034	broad.mit.edu	37	17	79801895	79801895	+	Missense_Mutation	SNP	T	T	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:79801895T>C	ENST00000331483.4	-	11	1742	c.1520A>G	c.(1519-1521)gAa>gGa	p.E507G	P4HB_ENST00000439918.2_Missense_Mutation_p.E463G|P4HB_ENST00000576390.1_Intron	NM_000918.3	NP_000909.2	P07237	PDIA1_HUMAN	prolyl 4-hydroxylase, beta polypeptide	507					cell redox homeostasis|glycerol ether metabolic process|lipid metabolic process|lipoprotein metabolic process|peptidyl-proline hydroxylation to 4-hydroxy-L-proline	cell surface|endoplasmic reticulum lumen|ER-Golgi intermediate compartment|extracellular region|melanosome|plasma membrane	electron carrier activity|procollagen-proline 4-dioxygenase activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			NS(1)|breast(1)|large_intestine(2)|lung(17)|urinary_tract(1)	22	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.013)|OV - Ovarian serous cystadenocarcinoma(97;0.0509)			GTATTACAGTTCATCTTTCAC	0.612000													193	130					0	0	1	0	0
FBF1	85302	broad.mit.edu	37	17	73914079	73914079	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:73914079C>A	ENST00000586717.1	-	21	2550	c.2277G>T	c.(2275-2277)gaG>gaT	p.E759D	FBF1_ENST00000319129.5_Missense_Mutation_p.E758D|FBF1_ENST00000389570.4_Missense_Mutation_p.E759D			A6NLR5	A6NLR5_HUMAN	Fas (TNFRSF6) binding factor 1	758										large_intestine(2)|ovary(1)|upper_aerodigestive_tract(1)	4						GGTGCGAGGCCTCCACGCGGG	0.657000													24	43					1.42536e-11	1.58949e-11	1	1	0
ADAMTS12	81792	broad.mit.edu	37	5	33576746	33576746	+	Missense_Mutation	SNP	A	A	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:33576746A>T	ENST00000504830.1	-	19	3720	c.3385T>A	c.(3385-3387)Ttg>Atg	p.L1129M	ADAMTS12_ENST00000352040.3_Missense_Mutation_p.L1044M	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	1129	Spacer 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						GAAGATGACAAGCCAGAACCA	0.483000										HNSCC(64;0.19)			30	68					0	0	1	0	0
CAPRIN2	65981	broad.mit.edu	37	12	30863342	30863342	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:30863342C>A	ENST00000251071.5	-	18	3628	c.2878G>T	c.(2878-2880)Ggt>Tgt	p.G960C	CAPRIN2_ENST00000417045.1_3'UTR|CAPRIN2_ENST00000395805.2_3'UTR|CAPRIN2_ENST00000298892.5_Missense_Mutation_p.G910C|CAPRIN2_ENST00000308433.5_Missense_Mutation_p.G626C	NM_001002259.1|NM_032156.3	NP_001002259.1|NP_115532.3	Q6IMN6	CAPR2_HUMAN	caprin family member 2	960					negative regulation of cell growth|negative regulation of translation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of transcription from RNA polymerase II promoter	mitochondrion|receptor complex	receptor binding|RNA binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(4)|large_intestine(13)|lung(16)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	48	all_lung(12;1.13e-09)|Lung NSC(12;7.98e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					CCAGAGTCACCACTGTTAAAG	0.502000													153	149					7.93641e-56	1.13495e-55	1	1	0
OR5T1	390155	broad.mit.edu	37	11	56043760	56043760	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:56043760G>T	ENST00000313033.2	+	1	732	c.646G>T	c.(646-648)Ggc>Tgc	p.G216C		NM_001004745.1	NP_001004745.1	Q8NG75	OR5T1_HUMAN	olfactory receptor, family 5, subfamily T, member 1	216					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(27)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	43	Esophageal squamous(21;0.00448)					CTACTTTGTGGGCTCTATTGA	0.408000													76	113					1.14856e-27	1.49178e-27	1	1	0
SEPT1	1731	broad.mit.edu	37	16	30392504	30392504	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:30392504C>A	ENST00000321367.3	-	7	688	c.643G>T	c.(643-645)Gtc>Ttc	p.V215F	SEPT1_ENST00000571393.1_Missense_Mutation_p.V168F|SEPT1_ENST00000605106.1_Missense_Mutation_p.V173F	NM_052838.4	NP_443070.5	Q8WYJ6	SEPT1_HUMAN	septin 1	168					cell cycle|cell division	microtubule organizing center|septin complex	GTP binding|protein binding			breast(2)|endometrium(1)|large_intestine(3)|lung(15)|ovary(1)|skin(1)|urinary_tract(1)	24			Colorectal(24;0.193)			TTGCCAATGACTGGGATGATG	0.582000													56	92					4.96213e-28	6.46014e-28	1	1	0
FN1	2335	broad.mit.edu	37	2	216240428	216240428	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:216240428G>A	ENST00000354785.4	-	37	6270	c.5901C>T	c.(5899-5901)ggC>ggT	p.G1967G	FN1_ENST00000359671.1_Silent_p.G1876G|FN1_ENST00000432072.2_Silent_p.G1877G|FN1_ENST00000346544.3_Silent_p.G1876G|FN1_ENST00000345488.5_Silent_p.G1876G|FN1_ENST00000421182.1_Silent_p.G1786G|FN1_ENST00000323926.6_Silent_p.G1967G|FN1_ENST00000357009.2_Silent_p.G1876G|FN1_ENST00000356005.4_Silent_p.G1786G|FN1_ENST00000336916.4_Silent_p.G1876G|FN1_ENST00000357867.4_Silent_p.G1786G|FN1_ENST00000443816.1_Silent_p.G1786G|FN1_ENST00000446046.1_Silent_p.G1876G			P02751	FINC_HUMAN	fibronectin 1	1966	Binds to FBLN1.|Fibronectin type-III 15.|Heparin-binding 2.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding		FN1/ALK(2)	NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(7)|endometrium(9)|kidney(8)|large_intestine(33)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	109		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGTAGTCAGTGCCTGGTTGTA	0.438000													14	28					0	0	1	0	0
TMC2	117532	broad.mit.edu	37	20	2596782	2596782	+	Splice_Site	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:2596782G>T	ENST00000358864.1	+	15	1887		c.e15-1		TMC2_ENST00000496948.1_Splice_Site	NM_080751.2	NP_542789.2	Q8TDI7	TMC2_HUMAN	transmembrane channel-like 2							integral to membrane				NS(1)|breast(3)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(14)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35						tccctctctAGCCTTCATATG	0.468000													32	43					2.70662e-09	2.90672e-09	1	1	0
MYO1B	4430	broad.mit.edu	37	2	192255219	192255219	+	Splice_Site	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:192255219G>C	ENST00000392318.3	+	18	2229		c.e18+1		MYO1B_ENST00000339514.4_Splice_Site|MYO1B_ENST00000304164.4_Splice_Site|MYO1B_ENST00000392316.1_Splice_Site	NM_001130158.1	NP_001123630.1	O43795	MYO1B_HUMAN	myosin IB							myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|central_nervous_system(6)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(19)|ovary(1)	55			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.104)|all cancers(119;0.236)			GACCAGCCAGGTAAGAAATTC	0.378000													16	20					0	0	1	0	0
ATXN3	4287	broad.mit.edu	37	14	92555107	92555107	+	Translation_Start_Site	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:92555107G>C	ENST00000502250.1	-	0	175				ATXN3_ENST00000554491.1_5'UTR|ATXN3_ENST00000532032.1_Missense_Mutation_p.L148V|ATXN3_ENST00000340660.6_Missense_Mutation_p.L93V|ATXN3_ENST00000503767.1_Missense_Mutation_p.L133V|ATXN3_ENST00000429774.2_Missense_Mutation_p.L133V|ATXN3_ENST00000545170.1_Missense_Mutation_p.L148V|ATXN3_ENST00000393287.5_Missense_Mutation_p.L148V	NM_001164780.1	NP_001158252.1	P54252	ATX3_HUMAN	ataxin 3						cell death|nervous system development|nucleotide-excision repair|regulation of transcription, DNA-dependent|synaptic transmission|transcription, DNA-dependent	cytoplasm|nuclear matrix|nucleoplasm	cysteine-type peptidase activity|protein binding			endometrium(2)|large_intestine(1)|lung(7)|prostate(1)|stomach(1)	12		all_cancers(154;0.0768)		COAD - Colon adenocarcinoma(157;0.224)		AAAAGTGCAAGATATGTATCT	0.323000													127	144					0	0	1	0	0
SH2B2	10603	broad.mit.edu	37	7	101944428	101944428	+	Silent	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:101944428G>C	ENST00000536178.1	+	2	768	c.723G>C	c.(721-723)ggG>ggC	p.G241G	SH2B2_ENST00000306803.8_Silent_p.G198G			O14492	SH2B2_HUMAN	SH2B adaptor protein 2	198	PH.				blood coagulation|insulin receptor signaling pathway|intracellular signal transduction	cytosol|plasma membrane	JAK pathway signal transduction adaptor activity|SH3/SH2 adaptor activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|skin(1)	9						AACGCGAGGGGGCGCTGCGCT	0.746000													7	5					0	0	1	0	0
ADAMTS5	11096	broad.mit.edu	37	21	28296649	28296649	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr21:28296649G>T	ENST00000284987.5	-	8	2637	c.2516C>A	c.(2515-2517)cCc>cAc	p.P839H	AP001601.2_ENST00000426771.1_RNA	NM_007038.3	NP_008969.2	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 5	839	Spacer.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	72						TGGTTTAGTGGGGTCTGTTGC	0.448000													56	99					1.78197e-24	2.24065e-24	1	1	0
UCK2	7371	broad.mit.edu	37	1	165860506	165860506	+	Silent	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:165860506C>T	ENST00000367879.4	+	3	606	c.303C>T	c.(301-303)atC>atT	p.I101I	UCK2_ENST00000372212.4_Silent_p.I101I	NM_012474.4	NP_036606.2	Q9BZX2	UCK2_HUMAN	uridine-cytidine kinase 2	101					pyrimidine base metabolic process|pyrimidine nucleoside salvage	cytosol	ATP binding|phosphotransferase activity, alcohol group as acceptor|uridine kinase activity			breast(1)|endometrium(2)|large_intestine(2)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	10	all_hematologic(923;0.048)|Acute lymphoblastic leukemia(8;0.155)					TCAAAGAAATCACTGAAGGGA	0.413000													37	94					0	0	1	0	0
KCNJ13	3769	broad.mit.edu	37	2	233635823	233635823	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:233635823C>T	ENST00000233826.3	-	2	389	c.250G>A	c.(250-252)Gat>Aat	p.D84N	KCNJ13_ENST00000410029.1_Missense_Mutation_p.D84N|GIGYF2_ENST00000409196.3_Intron|GIGYF2_ENST00000409480.1_Intron|GIGYF2_ENST00000409451.3_Intron|GIGYF2_ENST00000452341.2_Intron|GIGYF2_ENST00000409547.1_Intron|KCNJ13_ENST00000409779.1_Intron|GIGYF2_ENST00000373566.3_Intron|GIGYF2_ENST00000373563.4_Intron	NM_002242.4	NP_002233.2	O60928	IRK13_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 13	84						voltage-gated potassium channel complex	inward rectifier potassium channel activity			endometrium(3)|large_intestine(2)|lung(2)|stomach(1)|urinary_tract(1)	9		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0306)|Lung NSC(271;0.0908)		Epithelial(121;5.9e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000311)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)|GBM - Glioblastoma multiforme(43;0.0617)		AGTTCCAGATCACCATTCATC	0.473000													57	42					0	0	1	0	0
NPFFR2	10886	broad.mit.edu	37	4	73013158	73013158	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:73013158G>A	ENST00000308744.6	+	4	1296	c.1198G>A	c.(1198-1200)Gac>Aac	p.D400N	NPFFR2_ENST00000358749.3_Missense_Mutation_p.D298N|NPFFR2_ENST00000395999.1_Missense_Mutation_p.D301N|NPFFR2_ENST00000344413.5_3'UTR|NPFFR2_ENST00000506359.1_3'UTR	NM_004885.2	NP_004876.2	Q9Y5X5	NPFF2_HUMAN	neuropeptide FF receptor 2	400					detection of abiotic stimulus	actin cytoskeleton|integral to plasma membrane	neuropeptide receptor activity			NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(24)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	43			Lung(101;0.0935)|LUSC - Lung squamous cell carcinoma(112;0.138)			GATGCTCTCAGACTACGCTGA	0.478000													49	49					0	0	1	0	0
RAB36	9609	broad.mit.edu	37	22	23495282	23495282	+	Missense_Mutation	SNP	A	A	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr22:23495282A>G	ENST00000263116.2	+	5	528	c.488A>G	c.(487-489)gAg>gGg	p.E163G	RAB36_ENST00000341989.4_Missense_Mutation_p.E141G	NM_004914.2	NP_004905.2	O95755	RAB36_HUMAN	RAB36, member RAS oncogene family	163					protein transport|small GTPase mediated signal transduction	Golgi membrane	GTP binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.155)		TTTGAAATTGAGCGCTTTGAG	0.507000													69	98					0	0	1	0	0
COL14A1	7373	broad.mit.edu	37	8	121279123	121279123	+	Splice_Site	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr8:121279123G>A	ENST00000297848.3	+	25	3343		c.e25+1		COL14A1_ENST00000432943.2_Splice_Site|COL14A1_ENST00000309791.4_Splice_Site|COL14A1_ENST00000247781.3_Splice_Site	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1						cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			GCAAAAGAAGGTAAAAGAATA	0.353000													76	88					0	0	1	0	0
NAT9	26151	broad.mit.edu	37	17	72769175	72769175	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:72769175C>A	ENST00000357814.3	-	4	267	c.194G>T	c.(193-195)tGt>tTt	p.C65F	NAT9_ENST00000583757.1_Missense_Mutation_p.C64F|NAT9_ENST00000582524.1_Missense_Mutation_p.C65F|NAT9_ENST00000578822.1_Missense_Mutation_p.C70F|NAT9_ENST00000582870.1_Missense_Mutation_p.C69F|NAT9_ENST00000583476.1_Missense_Mutation_p.C65F|NAT9_ENST00000581136.1_Missense_Mutation_p.C65F|NAT9_ENST00000580632.1_Missense_Mutation_p.C64F|NAT9_ENST00000580216.1_5'UTR|NAT9_ENST00000580301.1_Missense_Mutation_p.C64F	NM_015654.3	NP_056469.2	Q9BTE0	NAT9_HUMAN	N-acetyltransferase 9 (GCN5-related, putative)	65	N-acetyltransferase.					protein complex	N-acetyltransferase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)	8						AATGAAGGTACACTCTGAGGA	0.567000													29	15					1.99505e-19	2.41506e-19	1	1	0
CLEC14A	161198	broad.mit.edu	37	14	38723983	38723983	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:38723983C>G	ENST00000342213.2	-	1	1591	c.1245G>C	c.(1243-1245)atG>atC	p.M415I		NM_175060.2	NP_778230.1	Q86T13	CLC14_HUMAN	C-type lectin domain family 14, member A	415						integral to membrane	sugar binding			breast(1)|cervix(2)|endometrium(2)|large_intestine(7)|lung(9)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	33	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00439)		CCAGTACTGTCATGGTCAAGA	0.557000													33	29					0	0	1	0	0
PIK3R2	5296	broad.mit.edu	37	19	18273235	18273235	+	Missense_Mutation	SNP	A	A	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:18273235A>G	ENST00000593731.1	+	9	1588	c.1028A>G	c.(1027-1029)aAa>aGa	p.K343R	PIK3R2_ENST00000222254.8_Missense_Mutation_p.K343R			O00459	P85B_HUMAN	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	343	SH2 1.				fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|negative regulation of anti-apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|T cell costimulation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	GTPase activator activity|phosphatidylinositol 3-kinase regulator activity|protein binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(12)|ovary(3)|pancreas(1)|stomach(1)	24						GTGAACGAGAAACTCCGGGAC	0.627000													17	38					0	0	1	0	0
KCNJ14	3770	broad.mit.edu	37	19	48965180	48965180	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:48965180G>A	ENST00000391884.1	+	1	675	c.199G>A	c.(199-201)Ggt>Agt	p.G67S	KCNJ14_ENST00000342291.2_Missense_Mutation_p.G67S			Q9UNX9	IRK14_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 14	67						voltage-gated potassium channel complex	inward rectifier potassium channel activity			cervix(1)|endometrium(2)|large_intestine(2)|lung(2)|skin(2)|urinary_tract(1)	10		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000109)|all cancers(93;0.000129)|Epithelial(262;0.0081)|GBM - Glioblastoma multiforme(486;0.0222)		CGTAAACCTGGGTGGCCAGGG	0.677000													17	11					0	0	1	0	0
GTF3C1	2975	broad.mit.edu	37	16	27556790	27556790	+	Silent	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:27556790C>G	ENST00000356183.4	-	2	291	c.276G>C	c.(274-276)gtG>gtC	p.V92V	GTF3C1_ENST00000561623.1_Silent_p.V92V	NM_001520.3	NP_001511.2	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide 1, alpha 220kDa	92						transcription factor TFIIIC complex	DNA binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|liver(3)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	80						CCTCCAAAGCCACCGGGTCCC	0.423000													37	39					0	0	1	0	0
SMARCA4	6597	broad.mit.edu	37	19	11143966	11143966	+	Splice_Site	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:11143966G>C	ENST00000358026.2	+	26	3831	c.3547G>C	c.(3547-3549)Gac>Cac	p.D1183H	SMARCA4_ENST00000590574.1_Splice_Site_p.D1183H|SMARCA4_ENST00000344626.4_Splice_Site_p.D1183H|SMARCA4_ENST00000589677.1_Splice_Site_p.D1183H|SMARCA4_ENST00000429416.3_Splice_Site_p.D1183H|SMARCA4_ENST00000413806.3_Splice_Site_p.D1183H|SMARCA4_ENST00000541122.2_Splice_Site_p.D1183H|SMARCA4_ENST00000444061.3_Splice_Site_p.D1183H|SMARCA4_ENST00000450717.3_Splice_Site_p.D1183H	NM_001128849.1	NP_001122321.1	P51532	SMCA4_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	1183	Helicase C-terminal.				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		adrenal_gland(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(23)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|liver(4)|lung(60)|ovary(10)|pancreas(7)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	163		all_lung(6;0.0512)|Lung NSC(9;0.0568)				CTTCCCCCAGGACCTGCAAGC	0.627000			"""F, N, Mis"""		NSCLC								107	48					0	0	1	0	0
LONP1	9361	broad.mit.edu	37	19	5693379	5693379	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:5693379G>C	ENST00000360614.3	-	17	2790	c.2633C>G	c.(2632-2634)gCc>gGc	p.A878G	LONP1_ENST00000593119.1_Missense_Mutation_p.A814G|LONP1_ENST00000585374.1_Missense_Mutation_p.A764G|LONP1_ENST00000590729.1_Missense_Mutation_p.A748G|LONP1_ENST00000540670.2_Missense_Mutation_p.A682G	NM_004793.2	NP_004784.2	P36776	LONM_HUMAN	lon peptidase 1, mitochondrial	878					cellular chaperone-mediated protein complex assembly|cellular response to oxidative stress|misfolded or incompletely synthesized protein catabolic process|mitochondrial DNA metabolic process|oxidation-dependent protein catabolic process|protein homooligomerization|response to hypoxia	mitochondrial nucleoid	ADP binding|ATP binding|ATP-dependent peptidase activity|DNA polymerase binding|G-quadruplex DNA binding|mitochondrial heavy strand promoter anti-sense binding|mitochondrial light strand promoter anti-sense binding|sequence-specific DNA binding|serine-type endopeptidase activity|single-stranded DNA binding|single-stranded RNA binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						GCCAGTCATGGCCAGATTCTG	0.652000													59	11					0	0	1	0	0
MYO1B	4430	broad.mit.edu	37	2	192275843	192275843	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:192275843G>T	ENST00000392318.3	+	27	3065	c.2818G>T	c.(2818-2820)Gag>Tag	p.E940*	MYO1B_ENST00000339514.4_Nonsense_Mutation_p.E882*|MYO1B_ENST00000304164.4_Nonsense_Mutation_p.E940*|MYO1B_ENST00000439065.2_Nonsense_Mutation_p.E185*|MYO1B_ENST00000392316.1_Nonsense_Mutation_p.E911*	NM_001130158.1	NP_001123630.1	O43795	MYO1B_HUMAN	myosin IB	940						myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|central_nervous_system(6)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(19)|ovary(1)	55			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.104)|all cancers(119;0.236)			TATTTATGAAGAGAAACTAGA	0.318000													13	75					0.000151284	0.000153792	1	1	0
TNFRSF1B	7133	broad.mit.edu	37	1	12251959	12251959	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:12251959G>T	ENST00000376259.3	+	4	525	c.436G>T	c.(436-438)Ggc>Tgc	p.G146C	TNFRSF1B_ENST00000492361.1_3'UTR|TNFRSF1B_ENST00000536782.1_Missense_Mutation_p.G146C	NM_001066.2	NP_001057.1	P20333	TNR1B_HUMAN	tumor necrosis factor receptor superfamily, member 1B	146					apoptosis	extracellular region|integral to membrane|membrane raft|plasma membrane	tumor necrosis factor receptor activity	p.G146R(1)		central_nervous_system(1)|liver(1)|lung(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	10	Ovarian(185;0.249)	Lung NSC(185;8.72e-05)|all_lung(284;9.92e-05)|Renal(390;0.000147)|Colorectal(325;0.000584)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|Colorectal(212;5.52e-07)|COAD - Colon adenocarcinoma(227;0.000345)|BRCA - Breast invasive adenocarcinoma(304;0.000353)|Kidney(185;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00302)|STAD - Stomach adenocarcinoma(313;0.00815)|READ - Rectum adenocarcinoma(331;0.0284)	Etanercept(DB00005)|Infliximab(DB00065)	GTGCCGCCCGGGCTTCGGCGT	0.682000													58	5					6.75472e-32	9.09416e-32	1	1	0
EIF3B	8662	broad.mit.edu	37	7	2404033	2404033	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:2404033G>A	ENST00000360876.4	+	6	1082	c.1026G>A	c.(1024-1026)tgG>tgA	p.W342*	EIF3B_ENST00000397011.2_Nonsense_Mutation_p.W342*	NM_001037283.1	NP_001032360.1	P55884	EIF3B_HUMAN	eukaryotic translation initiation factor 3, subunit B	342	Sufficient for interaction with EIF3E.				regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	nucleotide binding|protein complex scaffold|translation initiation factor activity			breast(2)|endometrium(4)|kidney(2)|large_intestine(3)|lung(11)|ovary(1)|skin(1)	24		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0833)|OV - Ovarian serous cystadenocarcinoma(56;7.76e-14)		ATGTGCGTTGGTCTCCTAAGG	0.463000													97	95					0	0	1	0	0
MMP10	4319	broad.mit.edu	37	11	102647046	102647046	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:102647046G>T	ENST00000279441.4	-	6	933	c.897C>A	c.(895-897)agC>agA	p.S299R		NM_002425.2	NP_002416.1	P09238	MMP10_HUMAN	matrix metallopeptidase 10 (stromelysin 2)	299	Hemopexin-like 1.				collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|liver(2)|lung(6)	22	all_epithelial(12;0.00961)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0303)|Lung(13;0.0828)|all cancers(10;0.116)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0145)		CCCTCAGAGTGCTGATGGCAT	0.438000													30	51					2.47316e-13	2.80325e-13	1	1	0
SLC12A1	6557	broad.mit.edu	37	15	48561931	48561931	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr15:48561931C>A	ENST00000396577.3	+	19	2587	c.2372C>A	c.(2371-2373)aCa>aAa	p.T791K	SLC12A1_ENST00000558405.1_Missense_Mutation_p.T791K|SLC12A1_ENST00000380993.3_Missense_Mutation_p.T791K	NM_001184832.1	NP_001171761.1	Q13621	S12A1_HUMAN	solute carrier family 12 (sodium/potassium/chloride transporter), member 1	791					potassium ion transport|sodium ion transport	integral to membrane|membrane fraction	sodium:potassium:chloride symporter activity			NS(2)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(30)|ovary(1)|prostate(2)|skin(1)	59		all_lung(180;0.00219)		all cancers(107;1.76e-09)|GBM - Glioblastoma multiforme(94;1.48e-06)	Bumetanide(DB00887)|Chlormerodrin(DB00534)|Chlorthalidone(DB00310)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Metolazone(DB00524)|Potassium Chloride(DB00761)|Torasemide(DB00214)|Trichlormethiazide(DB01021)	GCTCCCTTGACAGAGATTGAG	0.408000													13	16					4.3838e-07	4.58306e-07	1	1	0
PTK2B	2185	broad.mit.edu	37	8	27297834	27297834	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr8:27297834G>C	ENST00000397501.1	+	26	2723	c.1915G>C	c.(1915-1917)Gag>Cag	p.E639Q	PTK2B_ENST00000338238.4_Missense_Mutation_p.E639Q|PTK2B_ENST00000420218.2_Missense_Mutation_p.E639Q|PTK2B_ENST00000346049.5_Missense_Mutation_p.E639Q|PTK2B_ENST00000517339.1_Missense_Mutation_p.E639Q|PTK2B_ENST00000397497.4_Missense_Mutation_p.E385Q|PTK2B_ENST00000544172.1_Missense_Mutation_p.E639Q	NM_173174.2	NP_775266.1	Q14289	FAK2_HUMAN	protein tyrosine kinase 2 beta	639	Protein kinase.				apoptosis|bone resorption|positive regulation of cell proliferation|signal complex assembly	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|signal transducer activity			breast(2)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(17)|ovary(4)|skin(12)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	47		Ovarian(32;2.72e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|Epithelial(17;6.61e-10)|BRCA - Breast invasive adenocarcinoma(99;0.226)|Colorectal(74;0.229)		CGGGGTGCTGGAGAAAGGAGA	0.607000													28	31					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141747614	141747614	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:141747614C>A	ENST00000475668.2	+	22	2582	c.2528C>A	c.(2527-2529)gCc>gAc	p.A843D	MGAM_ENST00000549489.2_Missense_Mutation_p.A843D			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	843	Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CTTATCATTGCCCTAGATGAG	0.438000													10	16					3.27435e-08	3.45591e-08	1	1	0
ERCC2	2068	broad.mit.edu	37	19	45860917	45860917	+	Silent	SNP	C	C	G	rs148469762	byFrequency	TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:45860917C>G	ENST00000391945.4	-	13	1355	c.1278G>C	c.(1276-1278)ccG>ccC	p.P426P	ERCC2_ENST00000391944.3_Silent_p.P348P	NM_000400.3	NP_000391.1	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 2	426					cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			large_intestine(4)|lung(2)|ovary(1)|pancreas(1)|stomach(1)	9		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		TGGCAATGGTCGGGGTTCTGT	0.642000			"""Mis, N, F, S"""			"""skin basal cell, skin squamous cell, melanoma"""		Nucleotide excision repair (NER)	Xeroderma Pigmentosum				12	52					0	0	1	0	0
HCK	3055	broad.mit.edu	37	20	30672193	30672193	+	Splice_Site	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:30672193G>C	ENST00000534862.1	+	9	985		c.e9-1		HCK_ENST00000518730.1_Splice_Site|HCK_ENST00000375862.2_Splice_Site|HCK_ENST00000520553.1_Splice_Site|HCK_ENST00000538448.1_Splice_Site|HCK_ENST00000375852.2_Splice_Site	NM_001172132.1	NP_001165603.1	P08631	HCK_HUMAN	hemopoietic cell kinase						interspecies interaction between organisms|mesoderm development|regulation of defense response to virus by virus|viral reproduction	caveola|cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			NS(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(18)|ovary(2)|pancreas(1)|prostate(2)|skin(4)	36			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			CTCTGTTCCAGAGGGGAACGA	0.597000													12	26					0	0	1	0	0
P2RY14	9934	broad.mit.edu	37	3	150931787	150931787	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:150931787G>A	ENST00000309170.3	-	3	630	c.318C>T	c.(316-318)taC>taT	p.Y106Y	MED12L_ENST00000474524.1_Intron|P2RY14_ENST00000424796.2_Silent_p.Y106Y|MED12L_ENST00000273432.4_Intron	NM_001081455.1|NM_014879.3	NP_001074924.1|NP_055694.3	Q15391	P2Y14_HUMAN	purinergic receptor P2Y, G-protein coupled, 14	106						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled|UDP-activated nucleotide receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(1)	20			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			CAATGCTGACGTACATGTTGA	0.458000													38	33					0	0	1	0	0
TLR8	51311	broad.mit.edu	37	X	12939700	12939700	+	Silent	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chrX:12939700G>C	ENST00000218032.6	+	2	2628	c.2541G>C	c.(2539-2541)ctG>ctC	p.L847L	TLR8_ENST00000311912.5_Silent_p.L865L	NM_138636.4	NP_619542.1	Q9NR97	TLR8_HUMAN	toll-like receptor 8	847					cellular response to mechanical stimulus|defense response to virus|I-kappaB kinase/NF-kappaB cascade|immunoglobulin mediated immune response|inflammatory response|innate immune response|positive regulation of innate immune response|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process	endosome membrane	DNA binding|double-stranded RNA binding|single-stranded RNA binding|transmembrane receptor activity			breast(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(21)|ovary(4)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	50						TGGCTGCCCTGGCTCACCATT	0.393000													67	9					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	138414682	138414682	+	Missense_Mutation	SNP	A	A	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:138414682A>T	ENST00000409968.1	+	24	4505	c.4327A>T	c.(4327-4329)Aac>Tac	p.N1443Y	THSD7B_ENST00000272643.3_Missense_Mutation_p.N1446Y|THSD7B_ENST00000543459.1_Silent_p.I277I|THSD7B_ENST00000413152.2_Missense_Mutation_p.N1415Y					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		TTGGAACAATAACGAACGAAC	0.418000													30	36					0	0	1	0	0
DZIP1	22873	broad.mit.edu	37	13	96277135	96277135	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr13:96277135C>G	ENST00000347108.3	-	6	1291	c.859G>C	c.(859-861)Gac>Cac	p.D287H	DZIP1_ENST00000361156.3_Missense_Mutation_p.D287H|DZIP1_ENST00000376829.2_Missense_Mutation_p.D287H|DZIP1_ENST00000361396.2_Missense_Mutation_p.D287H			Q86YF9	DZIP1_HUMAN	DAZ interacting zinc finger protein 1	287					germ cell development|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleic acid binding|protein binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(20)|lung(11)|ovary(2)|pancreas(1)|skin(1)|stomach(1)	38	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.141)			TTCCACCTGTCAAATAACTTC	0.294000													4	15					0	0	1	0	0
CHRNA2	1135	broad.mit.edu	37	8	27327365	27327365	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr8:27327365G>A	ENST00000407991.1	-	3	815	c.207C>T	c.(205-207)ggC>ggT	p.G69G	CHRNA2_ENST00000520933.2_Silent_p.G69G|CHRNA2_ENST00000240132.2_Silent_p.G69G	NM_000742.3	NP_000733.2	Q15822	ACHA2_HUMAN	cholinergic receptor, nicotinic, alpha 2 (neuronal)	69						cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(5)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	23		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0208)|Epithelial(17;2.77e-10)|Colorectal(74;0.136)	Atracurium(DB00732)|Biperiden(DB00810)|Carbachol(DB00411)|Cisatracurium Besylate(DB00565)|Decamethonium(DB01245)|Dextromethorphan(DB00514)|Doxacurium chloride(DB01135)|Doxacurium(DB01334)|Gallamine Triethiodide(DB00483)|Levallorphan(DB00504)|Mecamylamine(DB00657)|Metocurine Iodide(DB00416)|Metocurine(DB01336)|Mivacurium(DB01226)|Nicotine(DB00184)|Pancuronium(DB01337)|Pipecuronium(DB01338)|Rocuronium(DB00728)|Tubocurarine(DB01199)	AGCGGTTGTAGCCCCGGAAGA	0.622000													77	9					0	0	1	0	0
CCT3	7203	broad.mit.edu	37	1	156294831	156294831	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:156294831G>C	ENST00000295688.3	-	6	634	c.354C>G	c.(352-354)caC>caG	p.H118Q	CCT3_ENST00000472765.2_Missense_Mutation_p.H73Q|CCT3_ENST00000368259.2_Missense_Mutation_p.H80Q|CCT3_ENST00000368261.3_Missense_Mutation_p.H73Q	NM_005998.4	NP_005989.3	P49368	TCPG_HUMAN	chaperonin containing TCP1, subunit 3 (gamma)	118					'de novo' posttranslational protein folding	cytoskeleton|cytosol|plasma membrane	ATP binding|unfolded protein binding			endometrium(4)|large_intestine(1)|liver(1)|lung(11)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	22	Hepatocellular(266;0.158)					CCACTGTTGGGTGCATCTGCT	0.433000													37	90					0	0	1	0	0
WBSCR22	114049	broad.mit.edu	37	7	73101013	73101013	+	Missense_Mutation	SNP	A	A	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:73101013A>G	ENST00000423166.2	+	3	250	c.203A>G	c.(202-204)gAg>gGg	p.E68G	WBSCR22_ENST00000464615.1_3'UTR|WBSCR22_ENST00000265758.2_Missense_Mutation_p.E45G|WBSCR22_ENST00000423497.1_Missense_Mutation_p.E45G			O43709	WBS22_HUMAN	Williams Beuren syndrome chromosome region 22	45						nucleus	methyltransferase activity			autonomic_ganglia(1)|large_intestine(2)|lung(9)|prostate(1)	13		Lung NSC(55;0.0908)|all_lung(88;0.198)				CGAGCATTGGAGCTTCTTTAT	0.483000													86	113					0	0	1	0	0
CLN3	1201	broad.mit.edu	37	16	28493802	28493802	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:28493802C>A	ENST00000569430.1	-	13	1721	c.902G>T	c.(901-903)gGa>gTa	p.G301V	CLN3_ENST00000360019.2_Missense_Mutation_p.G301V|CLN3_ENST00000355477.5_Missense_Mutation_p.G253V|CLN3_ENST00000567963.1_Missense_Mutation_p.G301V|CLN3_ENST00000568224.1_Missense_Mutation_p.G223V|CLN3_ENST00000395653.4_Missense_Mutation_p.G201V|CLN3_ENST00000357806.7_Missense_Mutation_p.G202V|CLN3_ENST00000357857.9_Missense_Mutation_p.G247V|CLN3_ENST00000354630.5_Intron|CLN3_ENST00000359984.7_Missense_Mutation_p.G301V|CLN3_ENST00000565316.1_Intron|CLN3_ENST00000357076.5_Missense_Mutation_p.G191V|CLN3_ENST00000535392.1_Missense_Mutation_p.G223V|CLN3_ENST00000333496.9_Missense_Mutation_p.G277V			Q13286	CLN3_HUMAN	ceroid-lipofuscinosis, neuronal 3	301					amyloid precursor protein catabolic process|arginine transport|associative learning|autophagic vacuole fusion|cell death|cellular amino acid metabolic process|cytosolic calcium ion homeostasis|galactosylceramide metabolic process|globoside metabolic process|glucosylceramide metabolic process|ionotropic glutamate receptor signaling pathway|lysosomal lumen acidification|lysosomal lumen pH elevation|negative regulation of catalytic activity|negative regulation of macroautophagy|negative regulation of neuron apoptosis|negative regulation of proteolysis|neuromuscular process controlling balance|neurotransmitter metabolic process|protein catabolic process|protein folding|protein processing|receptor-mediated endocytosis|regulation of action potential|sphingomyelin metabolic process|vacuolar transport	autophagic vacuole|caveola|cytosol|early endosome|Golgi membrane|Golgi stack|integral to endoplasmic reticulum membrane|late endosome|lysosomal membrane|membrane fraction|mitochondrion|neuron projection|nucleus|synaptic vesicle|trans-Golgi network	unfolded protein binding			breast(1)|large_intestine(2)|lung(11)|upper_aerodigestive_tract(1)	15						ACTTACAAGTCCCTGGTTAAT	0.542000													15	102					9.16793e-09	9.76969e-09	1	1	0
ZNF773	374928	broad.mit.edu	37	19	58018245	58018245	+	Missense_Mutation	SNP	A	A	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:58018245A>G	ENST00000282292.4	+	4	922	c.782A>G	c.(781-783)gAc>gGc	p.D261G	ZNF773_ENST00000598770.1_Missense_Mutation_p.D260G|ZNF773_ENST00000599847.1_Intron|ZNF773_ENST00000593916.1_Intron	NM_198542.1	NP_940944.1	Q6PK81	ZN773_HUMAN	zinc finger protein 773	261					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	22		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0254)		CGTAATGCTGACCTCATTCAA	0.418000													24	71					0	0	1	0	0
MDFI	4188	broad.mit.edu	37	6	41621214	41621214	+	Silent	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:41621214G>T	ENST00000373050.4	+	4	646	c.459G>T	c.(457-459)ctG>ctT	p.L153L				Q99750	MDFI_HUMAN	MyoD family inhibitor	214					cytoplasmic sequestering of transcription factor|dorsal/ventral axis specification|negative regulation of DNA binding|negative regulation of transcription from RNA polymerase II promoter|negative regulation of Wnt receptor signaling pathway	cytoplasm|nucleus				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|liver(2)|prostate(2)|skin(1)|urinary_tract(1)	8	Ovarian(28;0.0327)|Colorectal(47;0.121)		Colorectal(64;0.0123)|COAD - Colon adenocarcinoma(64;0.0264)|KIRC - Kidney renal clear cell carcinoma(1;0.138)			ACTGCGACCTGCCCTGCGACC	0.657000													97	112					3.46703e-50	4.9198e-50	1	1	0
CCDC50	152137	broad.mit.edu	37	3	191074896	191074896	+	Silent	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:191074896C>T	ENST00000392455.3	+	2	667	c.69C>T	c.(67-69)gtC>gtT	p.V23V	CCDC50_ENST00000392456.3_Silent_p.V23V	NM_174908.3	NP_777568.1	Q8IVM0	CCD50_HUMAN	coiled-coil domain containing 50	23						cytoplasm	protein binding			endometrium(5)|kidney(1)|large_intestine(4)|lung(12)|stomach(1)	23	all_cancers(143;8.88e-09)|Ovarian(172;0.103)|Breast(254;0.221)		LUSC - Lung squamous cell carcinoma(58;2.42e-06)|Lung(62;2.86e-06)	GBM - Glioblastoma multiforme(46;0.000136)		ATTTTGCTGTCCTGGAGGACC	0.398000													28	51					0	0	1	0	0
FPGT	8790	broad.mit.edu	37	1	74670542	74670542	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:74670542G>C	ENST00000609362.1	+	4	848	c.811G>C	c.(811-813)Gat>Cat	p.D271H	FPGT-TNNI3K_ENST00000533006.1_Intron|FPGT_ENST00000524915.1_Intron|FPGT-TNNI3K_ENST00000557284.2_Intron|TNNI3K_ENST00000370891.2_Intron|FPGT-TNNI3K_ENST00000370895.1_Intron|FPGT_ENST00000370894.5_Intron|FPGT-TNNI3K_ENST00000370899.3_Intron|FPGT_ENST00000370898.3_Missense_Mutation_p.D284H|FPGT-TNNI3K_ENST00000370893.1_Intron|FPGT_ENST00000534056.1_Intron	NM_003838.4	NP_003829.3			fucose-1-phosphate guanylyltransferase											breast(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(18)|ovary(1)|prostate(4)|skin(1)|urinary_tract(1)	39						TGTCTACACAGATAGCCTATT	0.368000													25	21					0	0	1	0	0
ACOX3	8310	broad.mit.edu	37	4	8383332	8383332	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:8383332C>T	ENST00000356406.5	-	14	1617	c.1540G>A	c.(1540-1542)Gcc>Acc	p.A514T	ACOX3_ENST00000413009.2_Missense_Mutation_p.A514T|ACOX3_ENST00000503233.1_Missense_Mutation_p.A514T	NM_003501.2	NP_003492.2	O15254	ACOX3_HUMAN	acyl-CoA oxidase 3, pristanoyl	514					bile acid metabolic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|pristanoyl-CoA oxidase activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(9)|lung(17)|prostate(1)|skin(3)|stomach(1)	42						GCTGCCAGGGCGACTTCGGAA	0.468000													27	44					0	0	1	0	0
GMPS	8833	broad.mit.edu	37	3	155615800	155615800	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:155615800G>T	ENST00000496455.2	+	3	629	c.294G>T	c.(292-294)aaG>aaT	p.K98N	GMPS_ENST00000295920.7_Intron|GMPS_ENST00000476145.1_3'UTR	NM_003875.2	NP_003866.1	P49915	GUAA_HUMAN	guanine monphosphate synthase		Glutamine amidotransferase type-1.				glutamine metabolic process|purine base biosynthetic process	cytosol	ATP binding|GMP synthase (glutamine-hydrolyzing) activity|GMP synthase activity			breast(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(5)|lung(12)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)		L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	CTATTGGCAAGCCTGTTCTTG	0.368000			T	MLL	AML								152	156					1.09856e-86	1.59162e-86	1	1	0
TANC2	26115	broad.mit.edu	37	17	61278265	61278265	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:61278265G>A	ENST00000424789.2	+	5	498	c.494G>A	c.(493-495)gGg>gAg	p.G165E	TANC2_ENST00000389520.4_Missense_Mutation_p.G165E|AC037445.1_ENST00000581421.1_RNA	NM_025185.3	NP_079461.2	Q9HCD6	TANC2_HUMAN	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2	165							binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|upper_aerodigestive_tract(3)	44						TGCAGCTATGGGGCTGTTACT	0.468000													127	78					0	0	1	0	0
OR4D1	26689	broad.mit.edu	37	17	56232574	56232574	+	Silent	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:56232574C>G	ENST00000268912.5	+	1	81	c.60C>G	c.(58-60)acC>acG	p.T20T		NM_012374.1	NP_036506.1	Q15615	OR4D1_HUMAN	olfactory receptor, family 4, subfamily D, member 1	20					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(2)|large_intestine(4)|lung(4)|ovary(1)|stomach(1)|urinary_tract(1)	13						TTTCACAGACCCAAGAGCTCC	0.453000													113	97					0	0	1	0	0
KIAA1217	56243	broad.mit.edu	37	10	24669846	24669846	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:24669846G>C	ENST00000376454.3	+	3	433	c.403G>C	c.(403-405)Gac>Cac	p.D135H	KIAA1217_ENST00000376462.1_Missense_Mutation_p.D55H|KIAA1217_ENST00000458595.1_Missense_Mutation_p.D135H|KIAA1217_ENST00000430453.2_Missense_Mutation_p.D56H|KIAA1217_ENST00000376452.3_Missense_Mutation_p.D135H	NM_019590.3	NP_062536.2	Q5T5P2	SKT_HUMAN	KIAA1217	135					embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						CAGTCTGGGTGACCCGGTCGA	0.502000													13	46					0	0	1	0	0
TGM1	7051	broad.mit.edu	37	14	24723917	24723917	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:24723917C>A	ENST00000206765.6	-	13	2164	c.2041G>T	c.(2041-2043)Gcc>Tcc	p.A681S	TGM1_ENST00000544573.1_Missense_Mutation_p.A239S	NM_000359.2	NP_000350.1	P22735	TGM1_HUMAN	transglutaminase 1	681					cell envelope organization|keratinization|peptide cross-linking	cornified envelope|intrinsic to membrane	acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)	24				GBM - Glioblastoma multiforme(265;0.0186)	L-Glutamine(DB00130)	TGCTGCTTGGCCAGCACCTGC	0.627000													62	77					1.7104e-27	2.21629e-27	1	1	0
FBXL7	23194	broad.mit.edu	37	5	15928355	15928355	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:15928355G>A	ENST00000504595.1	+	3	965	c.484G>A	c.(484-486)Gag>Aag	p.E162K	FBXL7_ENST00000510662.1_Missense_Mutation_p.E115K|FBXL7_ENST00000329673.7_Missense_Mutation_p.E150K	NM_001278317.1|NM_012304.3	NP_001265246.1|NP_036436.1	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	162					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(13)|lung(33)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	60						CCTGACGGGCGAGACCATCAA	0.662000													6	13					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9001859	9001859	+	Silent	SNP	T	T	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:9001859T>C	ENST00000397910.4	-	53	40592	c.40389A>G	c.(40387-40389)agA>agG	p.R13463R	MUC16_ENST00000380951.5_Silent_p.R104R	NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	13465					cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGGCTGGAGTTCTCGAGGTTG	0.488000													8	39					0	0	1	0	0
DLG5	9231	broad.mit.edu	37	10	79571722	79571722	+	Missense_Mutation	SNP	T	T	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:79571722T>A	ENST00000372391.2	-	22	4287	c.4282A>T	c.(4282-4284)Aac>Tac	p.N1428Y	DLG5_ENST00000459739.1_5'UTR|DLG5_ENST00000372388.2_Missense_Mutation_p.N1088Y	NM_004747.3	NP_004738.3	Q8TDM6	DLG5_HUMAN	discs, large homolog 5 (Drosophila)	1428	PDZ 3.				cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			breast(9)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(17)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	60	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			ACGTGGGGGTTGTACTGGGCC	0.667000													31	19					0	0	1	0	0
CEP250	11190	broad.mit.edu	37	20	34085680	34085680	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:34085680G>A	ENST00000397527.1	+	26	4159	c.3439G>A	c.(3439-3441)Gcc>Acc	p.A1147T	CEP250_ENST00000342580.4_Missense_Mutation_p.A1091T	NM_007186.3	NP_009117.2	Q9BV73	CP250_HUMAN	centrosomal protein 250kDa	1147	Gln/Glu-rich.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			GGCCCAGGAAGCCAAGGCAGC	0.662000													14	10					0	0	1	0	0
MIPOL1	145282	broad.mit.edu	37	14	37777260	37777260	+	Splice_Site	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:37777260G>C	ENST00000327441.7	+	9	1089		c.e9-1		MIPOL1_ENST00000545536.1_Splice_Site|MIPOL1_ENST00000536774.1_Splice_Site|MIPOL1_ENST00000537471.1_Splice_Site|MIPOL1_ENST00000556451.1_Splice_Site|MIPOL1_ENST00000396294.2_Splice_Site|MIPOL1_ENST00000539062.2_Splice_Site	NM_001195296.1|NM_001195297.1|NM_138731.6	NP_001182225.1|NP_001182226.1|NP_620059.1	Q8TD10	MIPO1_HUMAN	mirror-image polydactyly 1											breast(2)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	23	Breast(36;0.119)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;6.03e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.047)|all cancers(34;0.0953)|LUSC - Lung squamous cell carcinoma(13;0.0975)|BRCA - Breast invasive adenocarcinoma(188;0.196)	GBM - Glioblastoma multiforme(112;0.0358)		CTTTTTTCTAGGCTAGAAAAT	0.358000													38	56					0	0	1	0	0
UROD	7389	broad.mit.edu	37	1	45480182	45480182	+	Silent	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:45480182C>T	ENST00000246337.4	+	7	827	c.708C>T	c.(706-708)taC>taT	p.Y236Y	UROD_ENST00000494399.1_3'UTR	NM_000374.4	NP_000365.3	P06132	DCUP_HUMAN	uroporphyrinogen decarboxylase	236						cytosol|microtubule cytoskeleton|nucleus	uroporphyrinogen decarboxylase activity			endometrium(1)|large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)	4	Acute lymphoblastic leukemia(166;0.155)					CACTGCCTTACATCCGTGATG	0.542000									Porphyria Cutanea Tarda, Type II		OREG0013449	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	67	3					0	0	1	0	0
ARHGAP21	57584	broad.mit.edu	37	10	24910248	24910248	+	Missense_Mutation	SNP	A	A	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:24910248A>C	ENST00000396432.2	-	9	1062	c.576T>G	c.(574-576)aaT>aaG	p.N192K	ARHGAP21_ENST00000320481.6_5'UTR	NM_020824.3	NP_065875.3	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	191					signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(17)|lung(21)|ovary(7)|pancreas(1)|prostate(5)|skin(2)|stomach(2)|urinary_tract(1)	78						TATTGCGGGCATTGCCGCTAT	0.463000													6	7					0	0	1	0	0
IMP4	92856	broad.mit.edu	37	2	131103212	131103212	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:131103212G>T	ENST00000259239.3	+	5	1087	c.379G>T	c.(379-381)Gcc>Tcc	p.A127S	IMP4_ENST00000409935.1_Missense_Mutation_p.A127S	NM_033416.1	NP_219484.1	Q96G21	IMP4_HUMAN	IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast)	127	Brix.				rRNA processing|translation	nucleolus|ribonucleoprotein complex	aminoacyl-tRNA ligase activity|ATP binding|protein binding			central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|skin(1)|urinary_tract(1)	18	Colorectal(110;0.1)					ACTGGTGCGAGCCTGCAAAGC	0.647000													27	34					1.26454e-06	1.31703e-06	1	1	0
CNTN4	152330	broad.mit.edu	37	3	2908487	2908487	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:2908487G>A	ENST00000397461.1	+	7	890	c.506G>A	c.(505-507)cGc>cAc	p.R169H	CNTN4_ENST00000427331.1_Missense_Mutation_p.R169H|CNTN4_ENST00000418658.1_Missense_Mutation_p.R169H|CNTN4_ENST00000358480.3_5'UTR	NM_001206955.1	NP_001193884.1	Q8IWV2	CNTN4_HUMAN	contactin 4	169	Ig-like C2-type 2.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(19)|ovary(2)|pancreas(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		CAGGATAATCGCCGCTTTGTT	0.388000													63	123					0	0	1	0	0
SRSF12	135295	broad.mit.edu	37	6	89808433	89808433	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:89808433G>A	ENST00000452027.2	-	5	843	c.650C>T	c.(649-651)tCt>tTt	p.S217F		NM_080743.4	NP_542781.3	Q8WXF0	SRS12_HUMAN	serine/arginine-rich splicing factor 12	217	Arg/Ser-rich (RS domain).				assembly of spliceosomal tri-snRNP|cytoplasmic transport|negative regulation of nuclear mRNA splicing, via spliceosome|nuclear mRNA 5'-splice site recognition|regulation of alternative nuclear mRNA splicing, via spliceosome	nucleoplasm	nucleotide binding|RNA binding|RS domain binding|unfolded protein binding			autonomic_ganglia(1)|breast(1)|endometrium(2)|large_intestine(4)	8						TATTGAGTCAGAATGTCTTCC	0.398000													76	80					0	0	1	0	0
IVNS1ABP	10625	broad.mit.edu	37	1	185278644	185278644	+	Splice_Site	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:185278644C>A	ENST00000367498.3	-	3	605		c.e3-1		IVNS1ABP_ENST00000367497.1_Splice_Site|IVNS1ABP_ENST00000392007.3_Splice_Site|IVNS1ABP_ENST00000459929.1_Splice_Site	NM_006469.4	NP_006460.2	Q9Y6Y0	NS1BP_HUMAN	influenza virus NS1A binding protein						interspecies interaction between organisms|response to virus|RNA splicing|transcription from RNA polymerase III promoter	cytoplasm|cytoskeleton|spliceosomal complex|transcription factor complex				breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|ovary(4)|prostate(2)	29						ATAAATTTGGCTAGATGATGA	0.299000													22	39					1.40151e-16	1.64954e-16	1	1	0
CELF4	56853	broad.mit.edu	37	18	34852990	34852990	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr18:34852990G>T	ENST00000420428.2	-	7	1333	c.938C>A	c.(937-939)aCc>aAc	p.T313N	CELF4_ENST00000588597.1_Missense_Mutation_p.T302N|CELF4_ENST00000591287.1_Missense_Mutation_p.T312N|CELF4_ENST00000361795.5_Missense_Mutation_p.T311N|CELF4_ENST00000412753.1_Missense_Mutation_p.T312N|CELF4_ENST00000603232.1_Missense_Mutation_p.T312N|CELF4_ENST00000601019.1_Missense_Mutation_p.T311N|CELF4_ENST00000334919.5_Missense_Mutation_p.T303N|CELF4_ENST00000591282.1_Missense_Mutation_p.T313N	NM_020180.3	NP_064565.1	Q9BZC1	CELF4_HUMAN	CUGBP, Elav-like family member 4	313					embryo development|germ cell development|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	BRE binding|nucleotide binding|translation repressor activity, nucleic acid binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(8)|lung(18)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	44						TGAGGTTGGGGTCATAGGTGC	0.662000													40	36					6.21074e-16	7.24805e-16	1	1	0
GRIP2	80852	broad.mit.edu	37	3	14563323	14563323	+	RNA	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:14563323G>A	ENST00000273083.3	-	0	632							Q9C0E4	GRIP2_HUMAN	glutamate receptor interacting protein 2						synaptic transmission	cytosol|plasma membrane	protein binding			endometrium(5)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	25						CACCAGCCTGGCCCGGCAGCA	0.672000													14	13					0	0	1	0	0
HNRNPA2B1	3181	broad.mit.edu	37	7	26236509	26236509	+	Missense_Mutation	SNP	T	T	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:26236509T>C	ENST00000354667.4	-	5	597	c.429A>G	c.(427-429)atA>atG	p.I143M	HNRNPA2B1_ENST00000356674.7_Missense_Mutation_p.I131M	NM_031243.2	NP_112533.1	P22626	ROA2_HUMAN	heterogeneous nuclear ribonucleoprotein A2/B1	143	RRM 2.				RNA transport	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	nucleotide binding|protein binding|RNA binding|single-stranded telomeric DNA binding		HNRNPA2B1/ETV1(8)	breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	22						TATCAGTAATTATCTCAATGG	0.368000			T	ETV1	prostate								108	94					0	0	1	0	0
NALCN	259232	broad.mit.edu	37	13	102029296	102029296	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr13:102029296G>T	ENST00000251127.6	-	5	568	c.487C>A	c.(487-489)Cca>Aca	p.P163T	NALCN_ENST00000470333.1_5'UTR|NALCN_ENST00000376200.5_Missense_Mutation_p.P163T|NALCN_ENST00000376196.3_Missense_Mutation_p.P163T	NM_052867.2	NP_443099.1	Q8IZF0	NALCN_HUMAN	sodium leak channel, non-selective	163						integral to membrane	sodium channel activity|voltage-gated ion channel activity	p.P163T(1)		NS(1)|autonomic_ganglia(2)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(33)|liver(2)|lung(81)|ovary(8)|pancreas(3)|prostate(5)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	177	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					CTGGTCCTTGGCAGTTCAAAT	0.378000													27	36					2.41591e-17	2.8741e-17	1	1	0
HUS1B	135458	broad.mit.edu	37	6	656803	656803	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:656803C>G	ENST00000380907.2	-	1	160	c.142G>C	c.(142-144)Ggc>Cgc	p.G48R	EXOC2_ENST00000230449.4_Intron|EXOC2_ENST00000448181.3_Intron	NM_148959.3	NP_683762.2	Q8NHY5	HUS1B_HUMAN	HUS1 checkpoint homolog b (S. pombe)	48										endometrium(3)|large_intestine(1)|lung(7)	11	Ovarian(93;0.0733)	Breast(5;0.00139)|all_lung(73;0.0691)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.041)|BRCA - Breast invasive adenocarcinoma(62;0.0965)		TCGTGGAGGCCGCCGGAACCC	0.667000													14	7					0	0	1	0	0
PCYT1A	5130	broad.mit.edu	37	3	195968895	195968895	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:195968895C>T	ENST00000292823.2	-	8	804	c.632G>A	c.(631-633)cGg>cAg	p.R211Q	PCYT1A_ENST00000431016.1_Missense_Mutation_p.R211Q|PCYT1A_ENST00000419333.1_Missense_Mutation_p.R211Q	NM_005017.2	NP_005008.2	P49585	PCY1A_HUMAN	phosphate cytidylyltransferase 1, choline, alpha	211	Catalytic (Potential).					cytosol|soluble fraction	choline-phosphate cytidylyltransferase activity			cervix(1)|endometrium(3)|large_intestine(8)|lung(5)|ovary(1)	18	all_cancers(143;1.19e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.28e-24)|all cancers(36;1.01e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00259)	Choline(DB00122)	ATCATAATCCCGCACAATTCG	0.488000													54	97					0	0	1	0	0
TGS1	96764	broad.mit.edu	37	8	56717578	56717578	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr8:56717578C>T	ENST00000260129.5	+	10	2603	c.2126C>T	c.(2125-2127)gCc>gTc	p.A709V		NM_024831.6	NP_079107.6	Q96RS0	TGS1_HUMAN	trimethylguanosine synthase 1	709	Sufficient for catalytic activity.				cellular lipid metabolic process|ncRNA metabolic process|regulation of transcription, DNA-dependent|RNA capping|spliceosomal snRNP assembly|transcription, DNA-dependent	Cajal body|cytosol	RNA trimethylguanosine synthase activity			breast(3)|central_nervous_system(1)|endometrium(4)|large_intestine(5)|lung(10)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	29		all_lung(136;0.119)|all_epithelial(80;0.125)|Lung NSC(129;0.147)	Epithelial(17;0.00027)|all cancers(17;0.00251)			ATTCAGTTTGCCTTAACAGGA	0.398000													42	56					0	0	1	0	0
OR2C3	81472	broad.mit.edu	37	1	247695441	247695441	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:247695441C>T	ENST00000366487.3	-	2	734	c.373G>A	c.(373-375)Gct>Act	p.A125T	GCSAML_ENST00000527084.1_Intron|GCSAML_ENST00000366490.3_Intron|GCSAML_ENST00000527541.1_Intron|GCSAML_ENST00000366491.2_Intron|GCSAML_ENST00000531662.1_Intron|GCSAML_ENST00000463359.1_Intron|GCSAML_ENST00000366489.1_Intron	NM_198074.4	NP_932340	Q8N628	OR2C3_HUMAN	olfactory receptor, family 2, subfamily C, member 3	125					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|large_intestine(2)|lung(31)|ovary(1)|prostate(1)|skin(2)	43	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0242)	OV - Ovarian serous cystadenocarcinoma(106;0.0241)			CAGATGGCAGCGTAGCGGTCA	0.562000													25	63					0	0	1	0	0
SNTG2	54221	broad.mit.edu	37	2	1168818	1168818	+	Silent	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:1168818C>T	ENST00000308624.5	+	8	669	c.540C>T	c.(538-540)tcC>tcT	p.S180S	SNTG2_ENST00000467759.1_3'UTR|SNTG2_ENST00000407292.1_Intron	NM_018968.3	NP_061841.2	Q9NY99	SNTG2_HUMAN	syntrophin, gamma 2	180					central nervous system development	cytoplasm|cytoskeleton|sarcolemma|syntrophin complex	actin binding|PDZ domain binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|lung(20)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	52	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.00469)		all cancers(51;0.0178)|OV - Ovarian serous cystadenocarcinoma(76;0.07)|Epithelial(75;0.0864)|GBM - Glioblastoma multiforme(21;0.173)		GTGGGGCCTCCTCTCCCCTCT	0.473000													113	18					0	0	1	0	0
ERCC5	2073	broad.mit.edu	37	13	103510737	103510737	+	Missense_Mutation	SNP	G	G	A	rs146833751	byFrequency	TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr13:103510737G>A	ENST00000355739.4	+	6	2064	c.641G>A	c.(640-642)cGc>cAc	p.R214H	ERCC5_ENST00000535557.1_Missense_Mutation_p.R214H|BIVM-ERCC5_ENST00000602836.1_Silent_p.A639A	NM_000123.3	NP_000114			excision repair cross-complementing rodent repair deficiency, complementation group 5											breast(3)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(8)|lung(18)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	51	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					TTCACCAAGCGCAGAAGAACA	0.383000			"""Mis, N, F"""			"""skin basal cell, skin squamous cell, melanoma"""		Nucleotide excision repair (NER)	Xeroderma Pigmentosum				20	104					0	0	1	0	0
OXER1	165140	broad.mit.edu	37	2	42990186	42990186	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:42990186G>A	ENST00000378661.2	-	1	1215	c.1134C>T	c.(1132-1134)ggC>ggT	p.G378G		NM_148962.4	NP_683765.1	Q8TDS5	OXER1_HUMAN	oxoeicosanoid (OXE) receptor 1	378					regulation of cAMP biosynthetic process	integral to membrane|plasma membrane	5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding|5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding|5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding|G-protein coupled receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)	10						CGCTCACTGGGCCCTGCCGGC	0.662000													51	2					0	0	1	0	0
GABBR2	9568	broad.mit.edu	37	9	101148053	101148053	+	Splice_Site	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:101148053G>A	ENST00000259455.2	-	11	1990	c.1531C>T	c.(1531-1533)Ctc>Ttc	p.L511F		NM_005458.7	NP_005449.5	O75899	GABR2_HUMAN	gamma-aminobutyric acid (GABA) B receptor, 2	511					negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity		NOTCH1_ENST00000277541/GABBR2(2)	breast(4)|endometrium(4)|large_intestine(12)|lung(21)|ovary(2)|skin(4)|stomach(1)|urinary_tract(1)	49		Acute lymphoblastic leukemia(62;0.0527)			Baclofen(DB00181)	ATCTTTATGAGCCTGACAAGA	0.378000													29	45					0	0	1	0	0
C11orf30	56946	broad.mit.edu	37	11	76255837	76255837	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:76255837G>A	ENST00000529032.1	+	18	3244	c.3244G>A	c.(3244-3246)Gct>Act	p.A1082T	C11orf30_ENST00000524767.1_Missense_Mutation_p.A1097T|C11orf30_ENST00000343878.3_Missense_Mutation_p.A1082T|C11orf30_ENST00000525038.1_Missense_Mutation_p.A1083T|C11orf30_ENST00000525919.1_Missense_Mutation_p.A1083T|C11orf30_ENST00000334736.3_Missense_Mutation_p.A1082T|C11orf30_ENST00000524490.1_Missense_Mutation_p.A984T|C11orf30_ENST00000533248.1_Missense_Mutation_p.A991T			Q7Z589	EMSY_HUMAN	chromosome 11 open reading frame 30	1082	Gln-rich.				chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(10)|liver(1)|lung(23)|ovary(5)|prostate(2)|skin(4)|stomach(1)|urinary_tract(2)	60						GTCGCTCCCAGCTTCTTCAGA	0.478000													49	55					0	0	1	0	0
RNF112	7732	broad.mit.edu	37	17	19319264	19319264	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:19319264C>T	ENST00000461366.1	+	14	1887	c.1672C>T	c.(1672-1674)Ctc>Ttc	p.L558F		NM_007148.4	NP_009079.2	Q7Z5V9	Q7Z5V9_HUMAN	ring finger protein 112	558							GTP binding|GTPase activity|zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)|ovary(2)|prostate(1)|urinary_tract(1)	12						GGGGGCCGGGCTCATGGGCCT	0.692000													8	11					0	0	1	0	0
MAML2	84441	broad.mit.edu	37	11	95712374	95712374	+	Missense_Mutation	SNP	T	T	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:95712374T>C	ENST00000524717.1	-	5	4493	c.3209A>G	c.(3208-3210)aAt>aGt	p.N1070S		NM_032427.1	NP_115803.1	Q8IZL2	MAML2_HUMAN	mastermind-like 2 (Drosophila)	1070					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity		CRTC3/MAML2(26)|CRTC1/MAML2(516)	breast(2)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(8)|lung(12)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	43		Acute lymphoblastic leukemia(157;2.63e-05)|all_hematologic(158;0.00837)				CCTCGACTGATTCAACCCTGT	0.512000			T	"""MECT1, CRTC3"""	salivary gland mucoepidermoid								27	29					0	0	1	0	0
TAS2R9	50835	broad.mit.edu	37	12	10962143	10962143	+	Missense_Mutation	SNP	A	A	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:10962143A>T	ENST00000240691.2	-	1	624	c.532T>A	c.(532-534)Ttc>Atc	p.F178I		NM_023917.2	NP_076406.1	Q9NYW1	TA2R9_HUMAN	taste receptor, type 2, member 9	178					sensory perception of taste	integral to membrane	taste receptor activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						AACTGTTTGAAAGTACCTGGA	0.378000													26	54					0	0	1	0	0
ANKRD35	148741	broad.mit.edu	37	1	145561389	145561389	+	Silent	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:145561389C>T	ENST00000355594.4	+	10	1164	c.1077C>T	c.(1075-1077)ggC>ggT	p.G359G		NM_144698.3	NP_653299.4	Q8N283	ANR35_HUMAN	ankyrin repeat domain 35	359										NS(1)|biliary_tract(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(9)|lung(16)|ovary(4)|prostate(3)|skin(2)|urinary_tract(1)	47	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GAAAGCAAGGCTCTAGTCTCC	0.582000													22	30					0	0	1	0	0
MMP20	9313	broad.mit.edu	37	11	102477386	102477386	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:102477386C>T	ENST00000260228.2	-	6	845	c.833G>A	c.(832-834)gGg>gAg	p.G278E	MMP20_ENST00000544938.1_5'UTR	NM_004771.3	NP_004762.2	O60882	MMP20_HUMAN	matrix metallopeptidase 20	278					proteolysis|regulation of enamel mineralization	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|protein binding|zinc ion binding	p.G278E(1)		endometrium(1)|kidney(4)|large_intestine(3)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27	all_cancers(8;8.95e-05)|all_epithelial(12;0.00227)|Lung NSC(15;0.139)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0216)|Lung(13;0.0711)|all cancers(10;0.0889)|LUSC - Lung squamous cell carcinoma(19;0.13)	BRCA - Breast invasive adenocarcinoma(274;0.0161)		AGTGGGCTTCCCCAGGAATAC	0.537000													6	50					0	0	1	0	0
SLC9A4	389015	broad.mit.edu	37	2	103120009	103120009	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:103120009C>A	ENST00000295269.4	+	3	1280	c.823C>A	c.(823-825)Ctt>Att	p.L275I		NM_001011552.3	NP_001011552.2	Q6AI14	SL9A4_HUMAN	solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4	275					regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43						CGTTGTGGGGCTTGGAGGGGT	0.388000													22	32					5.35047e-06	5.53082e-06	1	1	0
PALD1	27143	broad.mit.edu	37	10	72293777	72293777	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:72293777G>T	ENST00000263563.6	+	8	1238	c.970G>T	c.(970-972)Gtc>Ttc	p.V324F		NM_014431.2	NP_055246.2			phosphatase domain containing, paladin 1																		CCTGGGCATGGTCCTGGGCAC	0.701000													15	12					6.72482e-11	7.37993e-11	1	1	0
FAT2	2196	broad.mit.edu	37	5	150925116	150925116	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:150925116C>G	ENST00000261800.5	-	9	5584	c.5572G>C	c.(5572-5574)Gtc>Ctc	p.V1858L		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	1858	Cadherin 16.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TGAATGATGACTTGGGCAGGT	0.463000													17	66					0	0	1	0	0
ATP8B4	79895	broad.mit.edu	37	15	50211048	50211048	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr15:50211048C>A	ENST00000284509.6	-	19	2164	c.2023G>T	c.(2023-2025)Gga>Tga	p.G675*	ATP8B4_ENST00000559829.1_Nonsense_Mutation_p.G675*	NM_024837.2	NP_079113.2	Q8TF62	AT8B4_HUMAN	ATPase, class I, type 8B, member 4	675					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|urinary_tract(1)	73		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		TGTTTGTCTCCTGTTAGGACC	0.343000													33	45					1.90571e-15	2.20998e-15	1	1	0
DOCK9	23348	broad.mit.edu	37	13	99532221	99532221	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr13:99532221G>T	ENST00000376460.1	-	27	2954	c.2874C>A	c.(2872-2874)taC>taA	p.Y958*	DOCK9_ENST00000339416.2_Nonsense_Mutation_p.Y959*|DOCK9_ENST00000448493.2_Nonsense_Mutation_p.Y970*|DOCK9_ENST00000442173.1_Nonsense_Mutation_p.Y958*	NM_001130048.1|NM_015296.2	NP_001123520.1|NP_056111.1	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9	959					blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(18)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	59	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					AAAACCATGAGTACTAAAAGA	0.368000													18	21					2.35188e-11	2.61742e-11	1	1	0
VRTN	55237	broad.mit.edu	37	14	74824202	74824202	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:74824202C>A	ENST00000256362.4	+	2	957	c.716C>A	c.(715-717)cCt>cAt	p.P239H		NM_018228.2	NP_060698.2	Q9H8Y1	VRTN_HUMAN	vertebrae development associated	239					transposition, DNA-mediated		DNA binding|transposase activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(15)|ovary(5)|prostate(2)|skin(1)|urinary_tract(1)	41						TACTTTGCCCCTGTGGTGGGG	0.687000													46	76					3.28156e-27	4.23229e-27	1	1	0
EEF1D	1936	broad.mit.edu	37	8	144671790	144671790	+	Silent	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr8:144671790C>A	ENST00000532741.1	-	1	840	c.612G>T	c.(610-612)gtG>gtT	p.V204V	EEF1D_ENST00000532400.1_Intron|EEF1D_ENST00000442189.2_Silent_p.V154V|EEF1D_ENST00000395119.3_Intron|EEF1D_ENST00000419152.2_Intron|EEF1D_ENST00000524624.1_Intron|EEF1D_ENST00000317198.6_Intron|EEF1D_ENST00000423316.2_Silent_p.V154V|EEF1D_ENST00000531621.1_Intron|EEF1D_ENST00000526838.1_Intron|EEF1D_ENST00000529272.1_Intron|EEF1D_ENST00000528610.1_Intron			P29692	EF1D_HUMAN	eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)	0					positive regulation of I-kappaB kinase/NF-kappaB cascade	cytosol|eukaryotic translation elongation factor 1 complex	protein binding|signal transducer activity|translation elongation factor activity			breast(2)|cervix(1)|endometrium(1)|kidney(4)|lung(2)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)			GGTGGCAGGCCACCTGGTTTC	0.657000													23	18					3.28513e-13	3.71596e-13	1	1	0
MYCN	4613	broad.mit.edu	37	2	16082801	16082801	+	Silent	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:16082801G>T	ENST00000281043.3	+	2	912	c.615G>T	c.(613-615)gtG>gtT	p.V205V		NM_005378.4	NP_005369.2	P04198	MYCN_HUMAN	v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog	205					regulation of transcription from RNA polymerase II promoter	chromatin|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	31	all_cancers(1;1.35e-08)|all_neural(1;2.92e-24)|Lung SC(1;3.26e-07)|Medulloblastoma(1;6.9e-06)|all_lung(1;1.26e-05)|Glioma(3;0.135)|Acute lymphoblastic leukemia(172;0.155)|all_epithelial(1;0.169)|all_hematologic(175;0.197)		GBM - Glioblastoma multiforme(3;0.000332)			CAGCGCCCGTGCCCGCAGCCC	0.816000			A		neuroblastoma								3	2					0.115264	0.115473	1	1	0
GABRR1	2569	broad.mit.edu	37	6	89910940	89910940	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:89910940G>T	ENST00000435811.1	-	2	621	c.167C>A	c.(166-168)aCa>aAa	p.T56K	GABRR1_ENST00000454853.2_Missense_Mutation_p.T73K|GABRR1_ENST00000369451.3_5'UTR	NM_001256703.1	NP_001243632.1	P24046	GBRR1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, rho 1	73					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(7)|lung(16)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	35		all_cancers(76;9.49e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.46e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;0.000114)		BRCA - Breast invasive adenocarcinoma(108;0.00917)	Picrotoxin(DB00466)	TTCTGACTTTGTCAGAGGCGA	0.473000													73	105					2.25582e-47	3.15244e-47	1	1	0
MAP3K13	9175	broad.mit.edu	37	3	185198111	185198111	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:185198111G>A	ENST00000265026.3	+	13	2927	c.2593G>A	c.(2593-2595)Gac>Aac	p.D865N	MAP3K13_ENST00000535426.1_Missense_Mutation_p.D721N|TMEM41A_ENST00000475480.1_5'UTR|MAP3K13_ENST00000446828.1_Missense_Mutation_p.D658N|MAP3K13_ENST00000443863.1_Missense_Mutation_p.D721N|MAP3K13_ENST00000424227.1_Missense_Mutation_p.D865N	NM_004721.4	NP_004712.1	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase 13	865					activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			NS(1)|biliary_tract(1)|breast(3)|endometrium(3)|kidney(1)|large_intestine(13)|lung(22)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	54	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			AAATACCAGTGACCACTCAAA	0.488000													86	77					0	0	1	0	0
KIF4B	285643	broad.mit.edu	37	5	154393911	154393911	+	Silent	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:154393911G>T	ENST00000435029.4	+	1	652	c.492G>T	c.(490-492)cgG>cgT	p.R164R		NM_001099293.1	NP_001092763.1	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	164	Kinesin-motor.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(27)|ovary(2)|upper_aerodigestive_tract(1)	58	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			TAAATATACGGGAGGATCCTA	0.388000													19	124					2.89027e-11	3.20367e-11	1	1	0
FLVCR2	55640	broad.mit.edu	37	14	76107313	76107313	+	Silent	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:76107313C>A	ENST00000238667.4	+	7	1607	c.1251C>A	c.(1249-1251)ggC>ggA	p.G417G	FLVCR2_ENST00000556241.1_Intron|FLVCR2_ENST00000539311.1_Silent_p.G212G|FLVCR2_ENST00000556856.1_Intron|FLVCR2_ENST00000555027.1_Silent_p.G132G|FLVCR2_ENST00000553587.1_Intron	NM_017791.2	NP_060261.2	Q9UPI3	FLVC2_HUMAN	feline leukemia virus subgroup C cellular receptor family, member 2	417					transmembrane transport	integral to membrane|plasma membrane	heme binding|heme transporter activity			endometrium(3)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	15				BRCA - Breast invasive adenocarcinoma(234;0.029)		TTATGACTGGCTATCTCCCAC	0.532000													35	58					1.57351e-24	1.9876e-24	1	1	0
SDK2	54549	broad.mit.edu	37	17	71426748	71426748	+	Silent	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:71426748C>T	ENST00000392650.3	-	12	1485	c.1485G>A	c.(1483-1485)cgG>cgA	p.R495R	SDK2_ENST00000388726.3_Silent_p.R495R	NM_001144952.1	NP_001138424.1	Q58EX2	SDK2_HUMAN	sidekick cell adhesion molecule 2	495					cell adhesion	integral to membrane				breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(15)|lung(31)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	86						TGATGCGGGTCCGAGCTGAAA	0.587000													3	21					0	0	1	0	0
UBR4	23352	broad.mit.edu	37	1	19404471	19404471	+	Splice_Site	SNP	T	T	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:19404471T>G	ENST00000375267.2	-	104	15326	c.15323A>C	c.(15322-15324)aAg>aCg	p.K5108T	UBR4_ENST00000375254.3_Splice_Site_p.K5108T|UBR4_ENST00000375217.2_Splice_Site_p.K5101T|UBR4_ENST00000543981.1_Splice_Site_p.K772T|UBR4_ENST00000429347.2_Splice_Site_p.K631T|UBR4_ENST00000375226.2_Splice_Site_p.K5084T|UBR4_ENST00000375224.1_Splice_Site_p.K815T|UBR4_ENST00000375225.3_Splice_Site_p.K183T			Q5T4S7	UBR4_HUMAN	ubiquitin protein ligase E3 component n-recognin 4	5108					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		CCTCCTTACCTTAAACATGTT	0.507000													43	2					0	0	1	0	0
KLHL14	57565	broad.mit.edu	37	18	30350069	30350069	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr18:30350069C>A	ENST00000359358.4	-	2	924	c.486G>T	c.(484-486)aaG>aaT	p.K162N	AC012123.1_ENST00000426194.1_Intron|KLHL14_ENST00000358095.4_Missense_Mutation_p.K162N	NM_020805.1	NP_065856.1	Q9P2G3	KLH14_HUMAN	kelch-like family member 14	162						cytosol|endoplasmic reticulum membrane				breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(20)|ovary(2)	31						TGTGCAGGATCTTGCTGACCG	0.622000													65	74					2.73361e-28	3.57572e-28	1	1	0
ZSCAN10	84891	broad.mit.edu	37	16	3140433	3140433	+	Silent	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:3140433C>A	ENST00000252463.2	-	5	924	c.837G>T	c.(835-837)gtG>gtT	p.V279V	ZSCAN10_ENST00000575108.1_5'UTR|ZSCAN10_ENST00000538082.2_Silent_p.V197V	NM_032805.1	NP_116194.1	Q96SZ4	ZSC10_HUMAN	zinc finger and SCAN domain containing 10	279					negative regulation of transcription, DNA-dependent|viral reproduction	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(3)|endometrium(3)|kidney(1)|lung(8)|ovary(2)|prostate(1)|skin(4)|urinary_tract(1)	24						CGCCCTCAGCCACTTTGACCT	0.652000													95	135					1.70349e-48	2.40493e-48	1	1	0
NR2F2	7026	broad.mit.edu	37	15	96877679	96877679	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr15:96877679G>T	ENST00000394166.3	+	2	2206	c.817G>T	c.(817-819)Gcc>Tcc	p.A273S	NR2F2_ENST00000394171.2_Missense_Mutation_p.A120S|NR2F2_ENST00000421109.2_Missense_Mutation_p.A140S|NR2F2_ENST00000453270.2_Missense_Mutation_p.A120S	NM_021005.3	NP_066285.1	P24468	COT2_HUMAN	nuclear receptor subfamily 2, group F, member 2	273	Interaction with ZFPM2 (By similarity).|Ligand-binding (By similarity).				lipid metabolic process|negative regulation of cyclin-dependent protein kinase activity|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment	nucleus	ligand-regulated transcription factor activity|protein homodimerization activity|retinoic acid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription corepressor activity|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|liver(2)|lung(3)|ovary(2)|urinary_tract(1)	17	Lung NSC(78;0.0186)|Melanoma(26;0.0195)|all_lung(78;0.0297)		OV - Ovarian serous cystadenocarcinoma(32;0.0856)			CCTGGCCGCCGCCGGCCTGCA	0.652000													36	50					4.65686e-17	5.51628e-17	1	1	0
MFN2	9927	broad.mit.edu	37	1	12057360	12057360	+	Missense_Mutation	SNP	A	A	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:12057360A>G	ENST00000235329.5	+	6	803	c.481A>G	c.(481-483)Aac>Gac	p.N161D	MFN2_ENST00000444836.1_Missense_Mutation_p.N161D	NM_014874.3	NP_055689.1	O95140	MFN2_HUMAN	mitofusin 2	161					blood coagulation|mitochondrial fusion|mitochondrial membrane organization|mitochondrion localization|negative regulation of Ras protein signal transduction|negative regulation of smooth muscle cell proliferation|protein targeting to mitochondrion	cytosol|integral to membrane|intrinsic to mitochondrial outer membrane	GTP binding|GTPase activity|ubiquitin protein ligase binding			endometrium(4)|kidney(1)|large_intestine(4)|liver(2)|lung(3)|ovary(1)|pancreas(1)|prostate(2)|skin(2)	20	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;7.25e-06)|COAD - Colon adenocarcinoma(227;0.000302)|BRCA - Breast invasive adenocarcinoma(304;0.000329)|Kidney(185;0.000896)|KIRC - Kidney renal clear cell carcinoma(229;0.00274)|STAD - Stomach adenocarcinoma(313;0.00773)|READ - Rectum adenocarcinoma(331;0.0656)		TCAGACTGTGAACCAGCTGGC	0.572000													50	4					0	0	1	0	0
FAM53A	152877	broad.mit.edu	37	4	1656734	1656734	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:1656734G>A	ENST00000308132.6	-	4	1045	c.853C>T	c.(853-855)Cca>Tca	p.P285S	FAM53A_ENST00000461064.1_Missense_Mutation_p.P285S|FAM53A_ENST00000489363.1_Missense_Mutation_p.P285S|FAM53A_ENST00000472884.2_Missense_Mutation_p.P285S	NM_001174070.1	NP_001167541.1	Q6NSI3	FA53A_HUMAN	family with sequence similarity 53, member A	285						nucleus				breast(2)|central_nervous_system(2)|large_intestine(1)|lung(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10		all_epithelial(65;0.206)|Breast(71;0.212)	OV - Ovarian serous cystadenocarcinoma(23;0.0145)			TCCAAGGATGGGCGTGTCCAC	0.647000													27	54					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9057120	9057120	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:9057120G>T	ENST00000397910.4	-	3	30529	c.30326C>A	c.(30325-30327)aCc>aAc	p.T10109N		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	10111	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGAACTGGTGGTTCCCACATT	0.488000													38	186					2.87052e-16	3.37133e-16	1	1	0
PTGES2	80142	broad.mit.edu	37	9	130886051	130886051	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:130886051C>T	ENST00000338961.6	-	4	1360	c.616G>A	c.(616-618)Ggc>Agc	p.G206S	PTGES2_ENST00000277462.5_Missense_Mutation_p.G15S|PTGES2_ENST00000483625.1_5'UTR	NM_001256335.1|NM_025072.6	NP_001243264.1|NP_079348.1	Q9H7Z7	PGES2_HUMAN	prostaglandin E synthase 2	206					cell redox homeostasis|prostaglandin biosynthetic process	Golgi membrane|integral to membrane|mitochondrion|perinuclear region of cytoplasm	electron carrier activity|prostaglandin-E synthase activity|protein binding|protein disulfide oxidoreductase activity			endometrium(1)|large_intestine(1)|lung(2)	4						TACTTATTGCCGAACTCGGTC	0.592000													45	50					0	0	1	0	0
ALDH1L2	160428	broad.mit.edu	37	12	105459055	105459055	+	Missense_Mutation	SNP	A	A	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:105459055A>T	ENST00000258494.9	-	6	916	c.776T>A	c.(775-777)aTa>aAa	p.I259K	ALDH1L2_ENST00000424857.2_Missense_Mutation_p.I259K	NM_001034173.3	NP_001029345.2	Q3SY69	AL1L2_HUMAN	aldehyde dehydrogenase 1 family, member L2	259					10-formyltetrahydrofolate catabolic process|biosynthetic process	mitochondrion	acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity|phosphopantetheine binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(13)|prostate(2)|skin(3)|stomach(2)	35						CTGTCCATTTATCTCTGTCCA	0.458000													32	51					0	0	1	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102498707	102498707	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:102498707C>A	ENST00000360184.4	+	52	10146	c.9982C>A	c.(9982-9984)Ctg>Atg	p.L3328M		NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	3328	Stalk (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						CTGCCTGCTGCTGGGGGAAAG	0.577000													186	115					4.99412e-61	7.19779e-61	1	1	0
PPFIA2	8499	broad.mit.edu	37	12	81688795	81688795	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:81688795G>A	ENST00000550584.2	-	23	3039	c.2744C>T	c.(2743-2745)gCg>gTg	p.A915V	PPFIA2_ENST00000550359.2_Missense_Mutation_p.A762V|RP11-121G22.3_ENST00000549161.1_lincRNA|PPFIA2_ENST00000407050.4_Missense_Mutation_p.A841V|PPFIA2_ENST00000549396.1_Missense_Mutation_p.A915V|PPFIA2_ENST00000545296.2_Intron|PPFIA2_ENST00000333447.7_Missense_Mutation_p.A900V|PPFIA2_ENST00000549325.1_Missense_Mutation_p.A900V|PPFIA2_ENST00000541570.2_Missense_Mutation_p.A482V|PPFIA2_ENST00000548586.1_Missense_Mutation_p.A915V|PPFIA2_ENST00000443686.3_Missense_Mutation_p.A816V|PPFIA2_ENST00000541017.1_Missense_Mutation_p.A132V|PPFIA2_ENST00000552948.1_Missense_Mutation_p.A915V	NM_001220473.1	NP_001207402.1	B7Z663	B7Z663_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	841										NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(37)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)	85						CACGTACCACGCAGGCATTCC	0.398000													8	28					0	0	1	0	0
EFHB	151651	broad.mit.edu	37	3	19925991	19925991	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:19925991G>C	ENST00000295824.9	-	11	2211	c.2050C>G	c.(2050-2052)Ctc>Gtc	p.L684V	EFHB_ENST00000344838.4_Missense_Mutation_p.L554V	NM_144715.3	NP_653316.3	Q8N7U6	EFHB_HUMAN	EF-hand domain family, member B	684					signal transduction	proteinaceous extracellular matrix	calcium ion binding			breast(2)|endometrium(4)|kidney(1)|lung(17)|prostate(1)|urinary_tract(1)	26						AGTGTCCGGAGAGTCTTTTCT	0.393000													46	124					0	0	1	0	0
ITGA1	3672	broad.mit.edu	37	5	52183724	52183724	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:52183724C>G	ENST00000282588.6	+	8	1309	c.851C>G	c.(850-852)tCt>tGt	p.S284C		NM_181501.1	NP_852478.1	P56199	ITA1_HUMAN	integrin, alpha 1	284	VWFA.				axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|muscle contraction	integrin complex	collagen binding|receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(19)|ovary(2)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51		Lung NSC(810;5.05e-05)|Breast(144;0.0851)				GATGGAGAGTCTCATGACAAT	0.423000													11	49					0	0	1	0	0
DUSP27	92235	broad.mit.edu	37	1	167096802	167096802	+	Missense_Mutation	SNP	T	T	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:167096802T>G	ENST00000361200.2	+	6	2600	c.2434T>G	c.(2434-2436)Tgc>Ggc	p.C812G	DUSP27_ENST00000485151.1_Intron|DUSP27_ENST00000443333.1_Missense_Mutation_p.C812G|DUSP27_ENST00000271385.5_Missense_Mutation_p.C812G			Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27 (putative)	812					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(11)|liver(1)|lung(46)|ovary(5)|prostate(5)|skin(4)|upper_aerodigestive_tract(3)	89						CGCGGAAAGTTGCAGAAGCAA	0.562000													88	51					0	0	1	0	0
RRBP1	6238	broad.mit.edu	37	20	17639309	17639309	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:17639309C>A	ENST00000377813.1	-	3	2147	c.1844G>T	c.(1843-1845)aGc>aTc	p.S615I	RRBP1_ENST00000246043.4_Missense_Mutation_p.S615I|RRBP1_ENST00000455029.2_Intron|RRBP1_ENST00000377807.2_Missense_Mutation_p.S185I|RRBP1_ENST00000360807.4_Missense_Mutation_p.S185I			Q9P2E9	RRBP1_HUMAN	ribosome binding protein 1	615					protein transport|translation|transmembrane transport	integral to endoplasmic reticulum membrane|ribosome	receptor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(9)|ovary(2)|prostate(6)	28						TGCCTCTGGGCTCTGGGCCAC	0.493000													51	98					1.38909e-20	1.69642e-20	1	1	0
GNG4	2786	broad.mit.edu	37	1	235747123	235747123	+	Missense_Mutation	SNP	A	A	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:235747123A>G	ENST00000391854.2	-	3	469	c.16T>C	c.(16-18)Tct>Cct	p.S6P	GNG4_ENST00000450593.1_Missense_Mutation_p.S6P|GNG4_ENST00000366597.1_Missense_Mutation_p.S6P|GNG4_ENST00000366598.4_Missense_Mutation_p.S6P|GNG4_ENST00000484517.1_5'UTR	NM_001098722.1|NM_004485.3	NP_001092192.1|NP_004476.1	P50150	GBG4_HUMAN	guanine nucleotide binding protein (G protein), gamma 4	6					cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|negative regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	heterotrimeric G-protein complex	signal transducer activity			NS(1)|endometrium(2)|large_intestine(1)|lung(3)|prostate(1)	8	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00168)|Prostate(94;0.0776)|Acute lymphoblastic leukemia(190;0.23)	OV - Ovarian serous cystadenocarcinoma(106;0.000882)			CTGTTATTAGACATGCCCTCT	0.507000													70	156					0	0	1	0	0
EXOC5	10640	broad.mit.edu	37	14	57689135	57689135	+	Splice_Site	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:57689135C>A	ENST00000413566.2	-	13	1656		c.e13-1		EXOC5_ENST00000340918.7_Splice_Site	NM_006544.3	NP_006535.1	O00471	EXOC5_HUMAN	exocyst complex component 5						exocytosis|post-Golgi vesicle-mediated transport|protein transport|vesicle docking	cytoplasm				breast(3)|endometrium(1)|large_intestine(3)|lung(10)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	22						GATCAGAGAGCTTAAAAACAA	0.308000													22	31					1.96895e-08	2.0861e-08	1	1	0
GRIK2	2898	broad.mit.edu	37	6	102372594	102372594	+	Splice_Site	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:102372594G>A	ENST00000369138.1	+	12	2357	c.1867G>A	c.(1867-1869)Ggt>Agt	p.G623S	GRIK2_ENST00000369137.3_Intron|GRIK2_ENST00000369134.4_Splice_Site_p.G574S|GRIK2_ENST00000413795.1_Splice_Site_p.G623S|GRIK2_ENST00000318991.6_Splice_Site_p.G623S|GRIK2_ENST00000421544.1_Splice_Site_p.G623S	NM_001166247.1	NP_001159719.1	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	623					glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	CATGCAGCAAGGTATACGATT	0.498000													14	46					0	0	1	0	0
NEK5	341676	broad.mit.edu	37	13	52663442	52663442	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr13:52663442C>T	ENST00000355568.4	-	14	1355	c.1216G>A	c.(1216-1218)Gag>Aag	p.E406K		NM_199289.1	NP_954983.1	Q6P3R8	NEK5_HUMAN	NIMA-related kinase 5	406							ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(8)|lung(11)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	39		Breast(56;0.00173)|Lung NSC(96;0.0168)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;3.7e-08)		TGAAGGTACTCAGCAGGCCTT	0.333000													8	14					0	0	1	0	0
NTAN1	123803	broad.mit.edu	37	16	15133844	15133844	+	Silent	SNP	T	T	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:15133844T>A	ENST00000287706.3	-	8	713	c.621A>T	c.(619-621)cgA>cgT	p.R207R	PDXDC1_ENST00000535621.2_Intron	NM_001270766.1|NM_173474.3	NP_001257695.1|NP_775745.1	Q96AB6	NTAN1_HUMAN	N-terminal asparagine amidase	207						cytoplasm				endometrium(1)|large_intestine(4)|lung(3)	8						CTGCTAAAGTTCGCGCAGCAC	0.443000													129	154					0	0	1	0	0
KLHL14	57565	broad.mit.edu	37	18	30350105	30350105	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr18:30350105G>A	ENST00000359358.4	-	2	888	c.450C>T	c.(448-450)tcC>tcT	p.S150S	AC012123.1_ENST00000426194.1_Intron|KLHL14_ENST00000358095.4_Silent_p.S150S	NM_020805.1	NP_065856.1	Q9P2G3	KLH14_HUMAN	kelch-like family member 14	150	BTB.					cytosol|endoplasmic reticulum membrane				breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(20)|ovary(2)	31						CCGTGTCCAGGGACAGGGTCA	0.642000													70	102					0	0	1	0	0
RBAK	57786	broad.mit.edu	37	7	5103373	5103373	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:5103373G>A	ENST00000396912.1	+	5	805	c.286G>A	c.(286-288)Gac>Aac	p.D96N	RBAK-RBAKDN_ENST00000396904.2_Intron|RBAK-RBAKDN_ENST00000407184.1_Missense_Mutation_p.D96N|RBAK_ENST00000353796.3_Missense_Mutation_p.D96N	NM_021163.3	NP_066986.1	Q9NYW8	RBAK_HUMAN	RB-associated KRAB zinc finger	96					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			NS(1)|kidney(1)|large_intestine(2)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)	10		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0916)|OV - Ovarian serous cystadenocarcinoma(56;2.44e-14)		AGAAAACGAAGACAAACATTC	0.363000													19	28					0	0	1	0	0
NODAL	4838	broad.mit.edu	37	10	72195635	72195635	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:72195635G>C	ENST00000287139.3	-	2	297	c.298C>G	c.(298-300)Cct>Gct	p.P100A	AC022532.1_ENST00000420338.2_3'UTR	NM_018055.4	NP_060525.3	Q96S42	NODAL_HUMAN	nodal growth differentiation factor	100					growth	extracellular space	cytokine activity|growth factor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(4)|upper_aerodigestive_tract(2)	15						AGGTCCACAGGGCTGGACAGC	0.572000													19	52					0	0	1	0	0
TEAD2	8463	broad.mit.edu	37	19	49863219	49863219	+	Silent	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:49863219G>T	ENST00000377214.4	-	1	476	c.114C>A	c.(112-114)ggC>ggA	p.G38G	TEAD2_ENST00000311227.2_Silent_p.G38G|TEAD2_ENST00000598810.1_Silent_p.G38G|TEAD2_ENST00000601519.1_Silent_p.G38G|TEAD2_ENST00000593945.1_Silent_p.G38G|TEAD2_ENST00000539846.1_Intron			Q15562	TEAD2_HUMAN	TEA domain family member 2	38					hippo signaling cascade		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)	29		all_lung(116;7.65e-05)|Lung NSC(112;0.000132)|all_neural(266;0.0506)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00093)|GBM - Glioblastoma multiforme(486;0.0467)		CTGCATCCGGGCCCCCGTCAC	0.677000													74	32					1.1397e-45	1.58868e-45	1	1	0
INADL	10207	broad.mit.edu	37	1	62240939	62240939	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:62240939G>T	ENST00000371158.2	+	7	896	c.782G>T	c.(781-783)gGa>gTa	p.G261V	INADL_ENST00000316485.6_Missense_Mutation_p.G261V	NM_176877.2	NP_795352	Q8NI35	INADL_HUMAN	InaD-like (Drosophila)	261	PDZ 2.				intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(8)|liver(1)|lung(51)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)	103						CTAGGTTTTGGAATAGTTGGA	0.413000													61	96					6.70656e-16	7.81017e-16	1	1	0
MTMR3	8897	broad.mit.edu	37	22	30416019	30416019	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr22:30416019G>T	ENST00000333027.3	+	17	2699	c.2371G>T	c.(2371-2373)Gtc>Ttc	p.V791F	MTMR3_ENST00000406629.1_Missense_Mutation_p.V791F|MTMR3_ENST00000351488.3_Missense_Mutation_p.V791F|MTMR3_ENST00000323630.5_Missense_Mutation_p.V655F|CTA-85E5.10_ENST00000453743.2_RNA|CTA-85E5.10_ENST00000429350.1_RNA|MTMR3_ENST00000401950.2_Missense_Mutation_p.V791F	NM_153050.2|NM_153051.2	NP_694690.1|NP_694691.1	Q13615	MTMR3_HUMAN	myotubularin related protein 3	791					phosphatidylinositol dephosphorylation	cytoplasm|membrane|membrane fraction|nucleus	metal ion binding|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			breast(3)|large_intestine(3)|ovary(2)|skin(8)|upper_aerodigestive_tract(1)	17			OV - Ovarian serous cystadenocarcinoma(5;0.00204)|Epithelial(10;0.06)|all cancers(5;0.107)			TTCCCTGGAGGTCCCTGTGGA	0.537000													45	64					6.4771e-29	8.574e-29	1	1	0
INHBB	3625	broad.mit.edu	37	2	121107164	121107164	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:121107164G>C	ENST00000295228.3	+	2	984	c.938G>C	c.(937-939)cGc>cCc	p.R313P		NM_002193.2	NP_002184.2	P09529	INHBB_HUMAN	inhibin, beta B	313					activin receptor signaling pathway|cellular response to insulin stimulus|cellular response to starvation|defense response|fat cell differentiation|growth|negative regulation of follicle-stimulating hormone secretion|negative regulation of hepatocyte growth factor biosynthetic process|negative regulation of insulin secretion|ovarian follicle development|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation	extracellular region|perinuclear region of cytoplasm	cytokine activity|growth factor activity|hormone activity|host cell surface receptor binding|protein homodimerization activity			NS(1)|breast(1)|endometrium(2)|large_intestine(3)|lung(4)|pancreas(2)|skin(2)	15		Prostate(154;0.122)				ATTGACTTCCGCCTCATCGGC	0.632000													71	91					0	0	1	0	0
STX18	53407	broad.mit.edu	37	4	4459161	4459161	+	Missense_Mutation	SNP	T	T	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:4459161T>A	ENST00000306200.2	-	4	482	c.419A>T	c.(418-420)gAt>gTt	p.D140V	STX18_ENST00000505286.1_Missense_Mutation_p.D140V	NM_016930.2	NP_058626.1	Q9P2W9	STX18_HUMAN	syntaxin 18	140					ER to Golgi vesicle-mediated transport|intracellular protein transport	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	SNAP receptor activity			large_intestine(1)|lung(3)|upper_aerodigestive_tract(1)	5				UCEC - Uterine corpus endometrioid carcinoma (64;0.0534)		TTTCAAGTAATCTTCAATGAA	0.378000													32	21					0	0	1	0	0
CPSF3L	54973	broad.mit.edu	37	1	1248252	1248252	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:1248252G>A	ENST00000540437.1	-	14	1682	c.1227C>T	c.(1225-1227)ggC>ggT	p.G409G	CPSF3L_ENST00000435064.1_Silent_p.G403G|CPSF3L_ENST00000450926.2_Silent_p.G381G|CPSF3L_ENST00000411962.1_Silent_p.G305G|CPSF3L_ENST00000421495.2_Silent_p.G145G|CPSF3L_ENST00000462432.1_5'UTR|CPSF3L_ENST00000545578.1_Silent_p.G374G|CPSF3L_ENST00000419704.1_Silent_p.G302G	NM_001256456.1	NP_001243385.1	Q5TA45	INT11_HUMAN	cleavage and polyadenylation specific factor 3-like	403						Golgi apparatus|nucleus	hydrolase activity			endometrium(4)|kidney(2)|lung(3)|prostate(1)|upper_aerodigestive_tract(3)	13	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;6.71e-35)|OV - Ovarian serous cystadenocarcinoma(86;4.35e-21)|Colorectal(212;0.000166)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.00235)|BRCA - Breast invasive adenocarcinoma(365;0.00255)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0349)|Lung(427;0.201)		GCTCTGCCTGGCCCACCAGCT	0.632000													59	5					0	0	1	0	0
OLFM2	93145	broad.mit.edu	37	19	9968097	9968097	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:9968097G>A	ENST00000264833.4	-	4	607	c.422C>T	c.(421-423)gCa>gTa	p.A141V	OLFM2_ENST00000590841.1_Missense_Mutation_p.A63V	NM_058164.2	NP_477512.1	O95897	NOE2_HUMAN	olfactomedin 2	141						extracellular region				breast(1)|cervix(1)|endometrium(3)|large_intestine(8)|lung(9)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)	31						CCGCGTGTCTGCCTTGTACTG	0.597000													40	146					0	0	1	0	0
PTK6	5753	broad.mit.edu	37	20	62162261	62162261	+	Silent	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:62162261C>T	ENST00000217185.2	-	6	879	c.852G>A	c.(850-852)ctG>ctA	p.L284L	PTK6_ENST00000542869.1_Silent_p.L183L	NM_005975.3	NP_005966.1	Q13882	PTK6_HUMAN	protein tyrosine kinase 6	284	Protein kinase.					cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			endometrium(3)|kidney(1)|lung(5)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	15	all_cancers(38;2.51e-11)		Epithelial(9;1.5e-08)|all cancers(9;8.67e-08)|BRCA - Breast invasive adenocarcinoma(10;6.43e-06)			CCGAAACGGGCAGGACTTTCT	0.622000													32	15					0	0	1	0	0
RCSD1	92241	broad.mit.edu	37	1	167653169	167653169	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:167653169C>A	ENST00000367854.3	+	2	370	c.39C>A	c.(37-39)gaC>gaA	p.D13E	RCSD1_ENST00000537350.1_Missense_Mutation_p.D13E	NM_052862.3	NP_443094.3	Q6JBY9	CPZIP_HUMAN	RCSD domain containing 1	13										NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(2)|ovary(2)|prostate(2)|skin(2)|urinary_tract(1)	24	all_hematologic(923;0.215)					CCAATGTGGACAACTCGGCGT	0.587000													120	313					2.4537e-52	3.49083e-52	1	1	0
MIER1	57708	broad.mit.edu	37	1	67436628	67436628	+	Missense_Mutation	SNP	A	A	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:67436628A>G	ENST00000357692.2	+	10	1059	c.802A>G	c.(802-804)Aaa>Gaa	p.K268E	MIER1_ENST00000371016.1_Missense_Mutation_p.K268E|MIER1_ENST00000355977.6_Missense_Mutation_p.K188E|MIER1_ENST00000401041.1_Missense_Mutation_p.K304E|MIER1_ENST00000371018.3_Missense_Mutation_p.K268E|MIER1_ENST00000355356.3_Missense_Mutation_p.K251E|MIER1_ENST00000401042.3_Missense_Mutation_p.K251E|MIER1_ENST00000371014.1_Missense_Mutation_p.K304E	NM_001146110.1	NP_001139582.1	Q8N108	MIER1_HUMAN	mesoderm induction early response 1, transcriptional regulator	275	ELM2.|Interaction with HDAC1.				positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(3)|ovary(1)|urinary_tract(3)	15						ATCTCACATAAAAGACAATGA	0.353000													19	42					0	0	1	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96542225	96542225	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:96542225G>A	ENST00000456556.1	-	59	3586	c.3502C>T	c.(3502-3504)Caa>Taa	p.Q1168*	ANKRD36C_ENST00000419039.2_Nonsense_Mutation_p.Q195*|ANKRD36C_ENST00000420871.2_Nonsense_Mutation_p.Q419*|ANKRD36C_ENST00000295246.5_Nonsense_Mutation_p.Q589*					ankyrin repeat domain 36C											breast(1)|endometrium(8)|kidney(5)|lung(4)	18						AGCCTCTTTTGCTCTCCCTCT	0.313000													8	17					0	0	1	0	0
C16orf78	123970	broad.mit.edu	37	16	49407936	49407936	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:49407936C>A	ENST00000299191.3	+	1	203	c.86C>A	c.(85-87)tCt>tAt	p.S29Y		NM_144602.2	NP_653203.1	Q8WTQ4	CP078_HUMAN	chromosome 16 open reading frame 78	29										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|upper_aerodigestive_tract(1)	22						AGGCGCATGTCTGACCTCACC	0.502000													63	55					3.94839e-29	5.23921e-29	1	1	0
LRRC37A6P	387646	broad.mit.edu	37	10	27539241	27539241	+	RNA	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:27539241G>A	ENST00000574842.1	+	0	510				LRRC37A6P_ENST00000284414.4_RNA																							ATGTTCTGGAGGCTGAGCTGG	0.547000													52	43					0	0	1	0	0
CTTNBP2	83992	broad.mit.edu	37	7	117424464	117424464	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:117424464C>T	ENST00000160373.3	-	5	2204	c.2113G>A	c.(2113-2115)Gcc>Acc	p.A705T		NM_033427.2	NP_219499.1	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	705										breast(3)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(36)|ovary(4)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		GCCAGGGGGGCAGGACCACCA	0.507000													79	66					0	0	1	0	0
CHD6	84181	broad.mit.edu	37	20	40033665	40033665	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:40033665C>G	ENST00000373233.3	-	37	7893	c.7716G>C	c.(7714-7716)aaG>aaC	p.K2572N	CHD6_ENST00000480022.1_5'UTR	NM_032221.3	NP_115597.3	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	2572					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(24)|lung(53)|ovary(8)|prostate(5)|skin(8)|stomach(1)|urinary_tract(9)	129		Myeloproliferative disorder(115;0.00425)				GGCTACTCGGCTTGTCTTCCG	0.502000													75	189					0	0	1	0	0
ARFRP1	10139	broad.mit.edu	37	20	62337724	62337724	+	Silent	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:62337724C>T	ENST00000440854.1	-	4	386	c.249G>A	c.(247-249)caG>caA	p.Q83Q	ARFRP1_ENST00000359715.5_Silent_p.Q83Q|ARFRP1_ENST00000324228.2_Silent_p.Q83Q|ARFRP1_ENST00000609142.1_Silent_p.Q83Q|ARFRP1_ENST00000607873.1_Silent_p.Q36Q	NM_001134758.2|NM_001267544.1|NM_001267545.1|NM_001267547.1|NM_001267549.1|NM_003224.4	NP_001128230.1|NP_001254473.1|NP_001254474.1|NP_001254476.1|NP_001254478.1|NP_003215.1	Q13795	ARFRP_HUMAN	ADP-ribosylation factor related protein 1	83					small GTPase mediated signal transduction	Golgi apparatus|membrane fraction	GTP binding|GTPase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|skin(1)	7	all_cancers(38;9.53e-13)|all_epithelial(29;2.64e-14)|Lung NSC(23;7e-10)|all_lung(23;2.53e-09)		Epithelial(9;4.09e-08)|all cancers(9;1.7e-07)|OV - Ovarian serous cystadenocarcinoma(5;0.0102)			CCCACAAAGACTGCAGCTCTT	0.597000													86	218					0	0	1	0	0
SMARCA2	6595	broad.mit.edu	37	9	2115870	2115870	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:2115870G>T	ENST00000382203.1	+	25	3714	c.3505G>T	c.(3505-3507)Gtc>Ttc	p.V1169F	SMARCA2_ENST00000357248.2_Missense_Mutation_p.V1169F|SMARCA2_ENST00000382194.1_Missense_Mutation_p.V1169F|SMARCA2_ENST00000349721.2_Missense_Mutation_p.V1169F			P51531	SMCA2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	1169	Helicase C-terminal.				chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		GCAGAACGAGGTCCGGGTACT	0.572000													18	3					6.94344e-10	7.51526e-10	1	1	0
KANK4	163782	broad.mit.edu	37	1	62739459	62739459	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:62739459G>A	ENST00000371153.4	-	3	1695	c.1317C>T	c.(1315-1317)agC>agT	p.S439S	KANK4_ENST00000354381.3_Intron	NM_181712.4	NP_859063.3	Q5T7N3	KANK4_HUMAN	KN motif and ankyrin repeat domains 4	439										NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(49)|ovary(3)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	81						CAGACTCCATGCTGCCTAGAA	0.562000													116	105					0	0	1	0	0
BIRC6	57448	broad.mit.edu	37	2	32715215	32715215	+	Missense_Mutation	SNP	A	A	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:32715215A>C	ENST00000421745.2	+	43	8337	c.8203A>C	c.(8203-8205)Aat>Cat	p.N2735H		NM_016252.3	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	2735					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					CATGCAGCTTAATTGTAAGTT	0.358000													67	7					0	0	1	0	0
ZNF485	220992	broad.mit.edu	37	10	44111919	44111919	+	Missense_Mutation	SNP	C	C	T	rs138982373		TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:44111919C>T	ENST00000361807.3	+	5	622	c.428C>T	c.(427-429)tCg>tTg	p.S143L	ZNF485_ENST00000374437.2_Missense_Mutation_p.S52L|ZNF485_ENST00000374435.3_Missense_Mutation_p.S143L	NM_145312.3	NP_660355.2	Q8NCK3	ZN485_HUMAN	zinc finger protein 485	143					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(8)|skin(1)|urinary_tract(1)	16						AAATACAATTCGTCCTTTATT	0.413000													15	53					0	0	1	0	0
CAMSAP1	157922	broad.mit.edu	37	9	138719397	138719397	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:138719397G>C	ENST00000389532.4	-	8	1143	c.1079C>G	c.(1078-1080)cCt>cGt	p.P360R	CAMSAP1_ENST00000312405.6_Missense_Mutation_p.P82R|CAMSAP1_ENST00000409386.3_Missense_Mutation_p.P371R	NM_015447.3	NP_056262.3	Q5T5Y3	CAMP1_HUMAN	calmodulin regulated spectrin-associated protein 1	360						cytoplasm|microtubule				breast(3)|central_nervous_system(2)|endometrium(6)|kidney(4)|large_intestine(11)|lung(16)|ovary(3)|pancreas(1)|skin(1)	47				OV - Ovarian serous cystadenocarcinoma(145;1.4e-06)|Epithelial(140;1.11e-05)		CGGTACAGGAGGCCGGCTGCT	0.562000													19	32					0	0	1	0	0
FAM161A	84140	broad.mit.edu	37	2	62081096	62081096	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:62081096G>A	ENST00000404929.1	-	1	92	c.81C>T	c.(79-81)gtC>gtT	p.V27V	FAM161A_ENST00000405894.3_Silent_p.V27V	NM_001201543.1	NP_001188472.1	Q3B820	F161A_HUMAN	family with sequence similarity 161, member A	27					response to stimulus|visual perception	centrosome				breast(1)|endometrium(5)|large_intestine(8)|lung(4)|ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						CGTACTGGGCGACCCGCGCTC	0.667000													18	6					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237753123	237753123	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:237753123C>A	ENST00000366574.2	+	30	3946	c.3629C>A	c.(3628-3630)gCt>gAt	p.A1210D	RYR2_ENST00000360064.6_Missense_Mutation_p.A1208D|RYR2_ENST00000542537.1_Missense_Mutation_p.A1194D	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	1210	4 X approximate repeats.|B30.2/SPRY 2.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CTTGGAGTGGCTCAAGTGGGT	0.383000													23	39					1.64293e-13	1.8699e-13	1	1	0
FGD6	55785	broad.mit.edu	37	12	95485582	95485582	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:95485582C>T	ENST00000343958.4	-	17	3974	c.3751G>A	c.(3751-3753)Gta>Ata	p.V1251I	FGD6_ENST00000546711.1_Missense_Mutation_p.V1251I	NM_018351.3	NP_060821.3	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	1251					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			breast(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(14)|liver(1)|lung(12)|ovary(3)|prostate(3)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	56						GCTTGGCATACAATCTGAAAA	0.328000													9	25					0	0	1	0	0
ZMYND8	23613	broad.mit.edu	37	20	45912357	45912357	+	Silent	SNP	T	T	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:45912357T>C	ENST00000311275.7	-	9	1033	c.780A>G	c.(778-780)ctA>ctG	p.L260L	ZMYND8_ENST00000262975.4_Silent_p.L260L|ZMYND8_ENST00000372023.3_Silent_p.L255L|ZMYND8_ENST00000540497.1_Silent_p.L255L|ZMYND8_ENST00000468376.2_5'UTR|ZMYND8_ENST00000446994.2_Silent_p.L197L|ZMYND8_ENST00000396281.4_Silent_p.L260L|ZMYND8_ENST00000536340.1_Silent_p.L287L|ZMYND8_ENST00000471951.2_Silent_p.L280L|ZMYND8_ENST00000458360.2_Silent_p.L255L|ZMYND8_ENST00000352431.2_Silent_p.L280L|ZMYND8_ENST00000355972.4_Silent_p.L260L|ZMYND8_ENST00000360911.3_Silent_p.L255L|ZMYND8_ENST00000461685.1_Silent_p.L280L	NM_001281772.1|NM_001281778.1|NM_001281783.1	NP_001268701.1|NP_001268707.1|NP_001268712.1	Q9ULU4	PKCB1_HUMAN	zinc finger, MYND-type containing 8	260							protein binding|zinc ion binding			NS(1)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(22)|ovary(1)|prostate(3)|skin(2)|urinary_tract(8)	62			Epithelial(1;0.0289)|all cancers(1;0.0962)|OV - Ovarian serous cystadenocarcinoma(1;0.154)			GGCAAGCAGCTAGATAACATT	0.393000													14	75					0	0	1	0	0
PRODH2	58510	broad.mit.edu	37	19	36303753	36303753	+	Silent	SNP	C	C	G	rs142806923	byFrequency	TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:36303753C>G	ENST00000301175.3	-	2	200	c.183G>C	c.(181-183)ctG>ctC	p.L61L		NM_021232.1	NP_067055.1	Q9UF12	PROD2_HUMAN	proline dehydrogenase (oxidase) 2	61					glutamate biosynthetic process|proline catabolic process		proline dehydrogenase activity			haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(9)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21	all_lung(56;2.87e-07)|Lung NSC(56;4.32e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TCTCTGGAGGCAGCAAGTTCA	0.587000													19	20					0	0	1	0	0
FAM204A	63877	broad.mit.edu	37	10	120095128	120095128	+	Missense_Mutation	SNP	T	T	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:120095128T>C	ENST00000369183.4	-	4	519	c.260A>G	c.(259-261)cAt>cGt	p.H87R	FAM204A_ENST00000469758.1_5'UTR|FAM204A_ENST00000369172.4_Missense_Mutation_p.H87R	NM_022063.2	NP_071346.1	Q9H8W3	F204A_HUMAN	family with sequence similarity 204, member A	87										kidney(1)|large_intestine(5)|lung(4)|ovary(1)	11						CTGTTCAGAATGTTTTTTATG	0.303000													5	36					0	0	1	0	0
FUT5	2527	broad.mit.edu	37	19	5866680	5866680	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:5866680C>T	ENST00000252675.5	-	5	1619	c.1057G>A	c.(1057-1059)Gcc>Acc	p.A353T	FUT5_ENST00000588525.1_Missense_Mutation_p.A353T			Q11128	FUT5_HUMAN	fucosyltransferase 5 (alpha (1,3) fucosyltransferase)	353					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity|alpha(1,3)-fucosyltransferase activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)|upper_aerodigestive_tract(1)	12						TTCCAGCAGGCCTTGCAGAAA	0.652000													39	7					0	0	1	0	0
MSH2	4436	broad.mit.edu	37	2	47702220	47702220	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:47702220G>T	ENST00000406134.1	+	12	1878	c.1816G>T	c.(1816-1818)Gtc>Ttc	p.V606F	MSH2_ENST00000233146.2_Missense_Mutation_p.V606F|MSH2_ENST00000543555.1_Missense_Mutation_p.V540F			P43246	MSH2_HUMAN	mutS homolog 2	606	Interaction with EXO1.				B cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|double-strand break repair|intra-S DNA damage checkpoint|isotype switching|maintenance of DNA repeat elements|male gonad development|meiotic gene conversion|meiotic mismatch repair|negative regulation of neuron apoptosis|negative regulation of reciprocal meiotic recombination|positive regulation of helicase activity|postreplication repair|response to UV-B|response to X-ray|somatic hypermutation of immunoglobulin genes	MutSalpha complex|MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|guanine/thymine mispair binding|loop DNA binding|protein C-terminus binding|protein homodimerization activity|protein kinase binding|Y-form DNA binding	p.0?(2)|p.?(2)		NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(9)|kidney(5)|large_intestine(50)|lung(18)|ovary(5)|prostate(2)|skin(3)|small_intestine(1)|stomach(2)|urinary_tract(1)	112		all_hematologic(82;0.0359)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			AGATGCTGTTGTCAGCTTTGC	0.393000			"""D, Mis, N, F, S"""		"""colorectal, endometrial, ovarian"""	"""colorectal, endometrial, ovarian"""		Mismatch excision repair (MMR)	Turcot syndrome;Muir-Torre syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome				44	7					3.4345e-17	4.07708e-17	1	1	0
TRIML1	339976	broad.mit.edu	37	4	189068457	189068457	+	Silent	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:189068457C>A	ENST00000332517.3	+	6	1478	c.1338C>A	c.(1336-1338)tcC>tcA	p.S446S	TRIML1_ENST00000507581.1_3'UTR	NM_178556.3	NP_848651.2	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	446	B30.2/SPRY.				multicellular organismal development		ligase activity|zinc ion binding			NS(3)|breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(30)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	60		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		CTATCTTTTCCCCCTGCCTCC	0.562000													40	90					8.69298e-16	1.01022e-15	1	1	0
MUC6	4588	broad.mit.edu	37	11	1018244	1018244	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:1018244G>C	ENST00000421673.2	-	31	4607	c.4557C>G	c.(4555-4557)aaC>aaG	p.N1519K		NM_005961.2	NP_005952.2	Q6W4X9	MUC6_HUMAN	mucin 6, oligomeric mucus/gel-forming	1519	Pro-rich.|Thr-rich.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(8)|kidney(10)|large_intestine(6)|lung(43)|ovary(4)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	80		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TAGGTGTTTTGTTTGTGCTGA	0.547000													121	11					0	0	1	0	0
ZNF682	91120	broad.mit.edu	37	19	20117916	20117916	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:20117916C>A	ENST00000397165.2	-	4	555	c.395G>T	c.(394-396)gGa>gTa	p.G132V	ZNF682_ENST00000397162.1_Missense_Mutation_p.G100V|ZNF682_ENST00000595736.1_Missense_Mutation_p.G56V|ZNF682_ENST00000597972.1_Missense_Mutation_p.G138V|ZNF682_ENST00000596019.1_Intron|ZNF682_ENST00000358523.5_Missense_Mutation_p.G100V|ZNF682_ENST00000593468.1_3'UTR	NM_033196.2	NP_149973.1	O95780	ZN682_HUMAN	zinc finger protein 682	132					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(1)	14						TTGGTTAAGTCCATTATAAAT	0.323000													28	43					2.4375e-19	2.93137e-19	1	1	0
ZNF827	152485	broad.mit.edu	37	4	146807045	146807045	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:146807045C>A	ENST00000508784.1	-	4	1759	c.1532G>T	c.(1531-1533)aGc>aTc	p.S511I	ZNF827_ENST00000513320.1_Missense_Mutation_p.S161I|ZNF827_ENST00000379448.4_Missense_Mutation_p.S511I			Q17R98	ZN827_HUMAN	zinc finger protein 827	511					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48	all_hematologic(180;0.151)					CCCTCCCTGGCTAGTCCTCTC	0.602000													57	47					4.96213e-28	6.46014e-28	1	1	0
NOTCH1	4851	broad.mit.edu	37	9	139418227	139418227	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:139418227G>A	ENST00000277541.6	-	3	420	c.345C>T	c.(343-345)ggC>ggT	p.G115G	NOTCH1_ENST00000491649.1_5'UTR	NM_017617.3	NP_060087.3	P46531	NOTC1_HUMAN	notch 1	115	EGF-like 3.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(16)|central_nervous_system(17)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1183)|kidney(4)|large_intestine(1)|lung(57)|oesophagus(2)|ovary(3)|pancreas(1)|prostate(3)|skin(21)|upper_aerodigestive_tract(39)|urinary_tract(3)	1359	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GGTCGCAGGTGCCCCCGTTGC	0.687000			"""T, Mis, O"""	TRB@	T-ALL					HNSCC(8;0.001)			19	15					0	0	1	0	0
AE000661.37	0	broad.mit.edu	37	14	22934568	22934568	+	RNA	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:22934568C>T	ENST00000514473.2	-	0	225				AE000661.37_ENST00000556777.1_RNA|TRDC_ENST00000390477.2_RNA																							AAACCAAAGGCTTACAAAAAT	0.433000													23	30					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238275417	238275417	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:238275417G>C	ENST00000295550.4	-	11	5865	c.5413C>G	c.(5413-5415)Ctg>Gtg	p.L1805V	COL6A3_ENST00000472056.1_Missense_Mutation_p.L1198V|COL6A3_ENST00000353578.4_Missense_Mutation_p.L1599V|COL6A3_ENST00000347401.3_Missense_Mutation_p.L1604V|COL6A3_ENST00000409809.1_Missense_Mutation_p.L1599V|COL6A3_ENST00000346358.4_Missense_Mutation_p.L1605V	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	1805	Nonhelical region.|VWFA 9.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		AGTTCGGACAGCTCCTGGACG	0.517000													69	88					0	0	1	0	0
PAAF1	80227	broad.mit.edu	37	11	73625498	73625498	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:73625498G>C	ENST00000544909.1	+	6	1028	c.771G>C	c.(769-771)ttG>ttC	p.L257F	PAAF1_ENST00000535604.1_Missense_Mutation_p.L141F|PAAF1_ENST00000544552.1_Missense_Mutation_p.L239F|PAAF1_ENST00000310571.3_Missense_Mutation_p.L256F|PAAF1_ENST00000376384.5_Missense_Mutation_p.L239F|PAAF1_ENST00000536003.1_Missense_Mutation_p.L239F|PAAF1_ENST00000541951.1_Missense_Mutation_p.L141F			Q9BRP4	PAAF1_HUMAN	proteasomal ATPase-associated factor 1	256					interspecies interaction between organisms	proteasome complex	protein binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	24	Breast(11;7.42e-05)					TGCTGCTCTTGGCCCGGGAAG	0.498000													28	46					0	0	1	0	0
HPS1	3257	broad.mit.edu	37	10	100185614	100185614	+	Silent	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:100185614C>T	ENST00000325103.6	-	12	1349	c.1116G>A	c.(1114-1116)ctG>ctA	p.L372L	HPS1_ENST00000361490.4_Silent_p.L372L|HPS1_ENST00000467246.1_5'UTR	NM_000195.3	NP_000186.2	Q92902	HPS1_HUMAN	Hermansky-Pudlak syndrome 1	372					lysosome organization|response to stimulus|visual perception	cytoplasmic membrane-bounded vesicle|integral to plasma membrane|lysosome|membrane fraction|soluble fraction	protein dimerization activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(9)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	23		Colorectal(252;0.234)		Epithelial(162;3.87e-12)|all cancers(201;5.63e-10)		GCCACAGGGGCAGGCAGTACA	0.627000									Hermansky-Pudlak syndrome		OREG0020430	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	85					0	0	1	0	0
MKI67	4288	broad.mit.edu	37	10	129906934	129906934	+	Missense_Mutation	SNP	T	T	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:129906934T>G	ENST00000368654.3	-	13	3545	c.3170A>C	c.(3169-3171)gAg>gCg	p.E1057A	MKI67_ENST00000368653.3_Missense_Mutation_p.E697A	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	1057	16 X 122 AA approximate repeats.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TCCTGCTGGCTCTCTGTGCGT	0.547000													172	115					0	0	1	0	0
MATN4	8785	broad.mit.edu	37	20	43933116	43933116	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:43933116C>T	ENST00000537548.1	-	4	639	c.395G>A	c.(394-396)cGa>cAa	p.R132Q	MATN4_ENST00000360607.6_Missense_Mutation_p.R132Q|MATN4_ENST00000372754.1_Missense_Mutation_p.R132Q|MATN4_ENST00000353917.5_Missense_Mutation_p.R132Q|MATN4_ENST00000372751.4_Intron|MATN4_ENST00000372756.1_Missense_Mutation_p.R132Q|MATN4_ENST00000342716.4_Missense_Mutation_p.R132Q			O95460	MATN4_HUMAN	matrilin 4	132	VWFA 1.					extracellular region	protein binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	27		Myeloproliferative disorder(115;0.0122)				CTCTGGCGGTCGCGCGCCCTC	0.731000													6	19					0	0	1	0	0
HSP90B1	7184	broad.mit.edu	37	12	104327817	104327817	+	Silent	SNP	C	C	T	rs144387251	byFrequency	TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:104327817C>T	ENST00000299767.5	+	5	677	c.495C>T	c.(493-495)acC>acT	p.T165T		NM_003299.2	NP_003290.1	P14625	ENPL_HUMAN	heat shock protein 90kDa beta (Grp94), member 1	165					actin rod assembly|anti-apoptosis|cellular response to ATP|ER-associated protein catabolic process|protein folding|protein transport|regulation of phosphoprotein phosphatase activity|response to hypoxia|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|melanosome|microsome|midbody|perinuclear region of cytoplasm	ATP binding|calcium ion binding|low-density lipoprotein particle receptor binding|protein phosphatase binding|RNA binding|unfolded protein binding|virion binding			central_nervous_system(1)|kidney(5)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(1)|urinary_tract(4)	29					Rifabutin(DB00615)	ACCTTGGTACCATAGCCAAAT	0.438000													31	50					0	0	1	0	0
PRSS54	221191	broad.mit.edu	37	16	58314503	58314503	+	Silent	SNP	G	G	A	rs151211769		TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:58314503G>A	ENST00000219301.4	-	7	1207	c.813C>T	c.(811-813)gcC>gcT	p.A271A	CCDC113_ENST00000443128.2_3'UTR|PRSS54_ENST00000567164.1_Silent_p.A271A|PRSS54_ENST00000543437.1_Silent_p.A172A|CCDC113_ENST00000219299.4_3'UTR	NM_001080492.1	NP_001073961.1	Q6PEW0	PRS54_HUMAN	protease, serine, 54	271					proteolysis	extracellular region	serine-type endopeptidase activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(5)|ovary(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						GGGGAGGGCCGGCCCTCTCAG	0.527000													33	29					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240374392	240374392	+	Splice_Site	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:240374392G>C	ENST00000319653.9	+	6	4152	c.3922G>C	c.(3922-3924)Gac>Cac	p.D1308H		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	1308	FH2.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			TAATTTTAGAGACTCCAGTAC	0.363000													45	37					0	0	1	0	0
GPR139	124274	broad.mit.edu	37	16	20084882	20084882	+	Silent	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:20084882G>T	ENST00000570682.1	-	1	357	c.57C>A	c.(55-57)ccC>ccA	p.P19P		NM_001002911.2	NP_001002911.1	Q6DWJ6	GP139_HUMAN	G protein-coupled receptor 139	19						integral to membrane|plasma membrane				autonomic_ganglia(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	30						AGGCCGAGCCGGGGGACCACC	0.697000													15	5					1.2644e-06	1.31703e-06	1	1	0
FAM98C	147965	broad.mit.edu	37	19	38896273	38896273	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:38896273G>C	ENST00000252530.5	+	6	767	c.748G>C	c.(748-750)Gag>Cag	p.E250Q	FAM98C_ENST00000343358.7_Missense_Mutation_p.E224Q|FAM98C_ENST00000588262.1_Intron	NM_174905.3	NP_777565.3	Q17RN3	FA98C_HUMAN	family with sequence similarity 98, member C	250										endometrium(2)|large_intestine(3)|lung(6)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	15	all_cancers(60;3.95e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			TGACCGGGCAGAGGTGTGGTG	0.607000													23	36					0	0	1	0	0
RINT1	60561	broad.mit.edu	37	7	105190500	105190500	+	Splice_Site	SNP	A	A	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:105190500A>G	ENST00000257700.2	+	8	1227		c.e8-1			NM_021930.4	NP_068749.3	Q6NUQ1	RINT1_HUMAN	RAD50 interactor 1						cell cycle|G2/M transition DNA damage checkpoint|protein transport|vesicle-mediated transport	endoplasmic reticulum membrane	protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(9)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22						CTCCTTCCTTAGCCAGAATGG	0.328000													23	30					0	0	1	0	0
TESPA1	9840	broad.mit.edu	37	12	55357674	55357674	+	Silent	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:55357674G>T	ENST00000524622.1	-	6	754	c.93C>A	c.(91-93)ggC>ggA	p.G31G	TESPA1_ENST00000316577.8_Silent_p.G169G|TESPA1_ENST00000532804.1_Silent_p.G31G|TESPA1_ENST00000531122.1_Silent_p.G31G|TESPA1_ENST00000449076.1_Silent_p.G169G|TESPA1_ENST00000524959.1_5'UTR	NM_001261844.1|NM_014796.2	NP_001248773.1|NP_055611.1	A2RU30	K0748_HUMAN	thymocyte expressed, positive selection associated 1	169																	CTTGGCCAAAGCCCAGACTGA	0.478000													68	64					7.07328e-35	9.59325e-35	1	1	0
COL19A1	1310	broad.mit.edu	37	6	70890380	70890380	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:70890380G>T	ENST00000322773.4	+	44	2842	c.2740G>T	c.(2740-2742)Ggt>Tgt	p.G914C	COL19A1_ENST00000393344.1_Missense_Mutation_p.G536C	NM_001858.4	NP_001849.2	Q14993	COJA1_HUMAN	collagen, type XIX, alpha 1	914	Triple-helical region 5 (COL5).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(8)|lung(54)|ovary(3)|prostate(2)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	109						TGGAGATATAGGTTTCCCTGG	0.398000													40	46					2.56662e-36	3.50686e-36	1	1	0
QSOX1	5768	broad.mit.edu	37	1	180165664	180165664	+	Missense_Mutation	SNP	A	A	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:180165664A>G	ENST00000367602.3	+	12	1810	c.1736A>G	c.(1735-1737)gAc>gGc	p.D579G	QSOX1_ENST00000367600.5_Missense_Mutation_p.D579G			O00391	QSOX1_HUMAN	quiescin Q6 sulfhydryl oxidase 1	579					cell redox homeostasis|protein thiol-disulfide exchange	extracellular space|integral to Golgi membrane	flavin-linked sulfhydryl oxidase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(9)|ovary(1)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	31						TCAACTCTGGACCCTGGGAAG	0.642000													74	143					0	0	1	0	0
ROBO3	64221	broad.mit.edu	37	11	124738754	124738754	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:124738754C>A	ENST00000397801.1	+	2	409	c.217C>A	c.(217-219)Ctg>Atg	p.L73M	ROBO3_ENST00000538940.1_Missense_Mutation_p.L51M	NM_022370.3	NP_071765.2	Q96MS0	ROBO3_HUMAN	roundabout, axon guidance receptor, homolog 3 (Drosophila)	73	Ig-like C2-type 1.				axon midline choice point recognition	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	35	all_hematologic(175;0.215)	Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|Breast(109;0.0481)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0296)		GCCGCCAGATCTGCTGGTCTC	0.667000													9	19					2.17888e-05	2.23558e-05	1	1	0
KCNH8	131096	broad.mit.edu	37	3	19389402	19389402	+	Silent	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:19389402C>A	ENST00000328405.2	+	5	1022	c.756C>A	c.(754-756)tcC>tcA	p.S252S	KCNH8_ENST00000475063.1_3'UTR	NM_144633.2	NP_653234.2	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 8	252						integral to membrane	two-component sensor activity			NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(3)|lung(37)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	77						ACGACCTGTCCACAACTCGGA	0.418000													239	113					1.47544e-110	2.14327e-110	1	1	0
ACBD7	414149	broad.mit.edu	37	10	15120593	15120593	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:15120593G>A	ENST00000356189.5	-	4	250	c.203C>T	c.(202-204)aCg>aTg	p.T68M	ACBD7_ENST00000496890.1_5'UTR	NM_001039844.2	NP_001034933.1	Q8N6N7	ACBD7_HUMAN	acyl-CoA binding domain containing 7	68	ACB.						fatty-acyl-CoA binding			endometrium(1)|lung(4)|prostate(1)	6						CGCATCTTCCGTCGACAACCC	0.363000													14	48					0	0	1	0	0
CYP7A1	1581	broad.mit.edu	37	8	59409268	59409268	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr8:59409268G>A	ENST00000301645.3	-	3	940	c.803C>T	c.(802-804)tCc>tTc	p.S268F		NM_000780.3	NP_000771.2	P22680	CP7A1_HUMAN	cytochrome P450, family 7, subfamily A, polypeptide 1	268					bile acid biosynthetic process|cellular lipid metabolic process|cellular response to cholesterol|cellular response to glucose stimulus|cholesterol catabolic process|cholesterol homeostasis|regulation of bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholesterol 7-alpha-monooxygenase activity|electron carrier activity|heme binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|prostate(1)|urinary_tract(1)	34		all_lung(136;0.0271)|Lung NSC(129;0.0351)|all_epithelial(80;0.0554)				ATCAAAGGTGGACAAAGTGTC	0.498000									Neonatal Giant Cell Hepatitis				101	132					0	0	1	0	0
PNLIPRP3	119548	broad.mit.edu	37	10	118228771	118228771	+	Silent	SNP	T	T	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:118228771T>C	ENST00000369230.3	+	9	1148	c.1002T>C	c.(1000-1002)aaT>aaC	p.N334N		NM_001011709.2	NP_001011709.2	Q17RR3	LIPR3_HUMAN	pancreatic lipase-related protein 3	334					lipid catabolic process	extracellular region	triglyceride lipase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(29)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	50				all cancers(201;0.0131)		ACTTCAAAAATATGAAGACTA	0.353000													29	16					0	0	1	0	0
KIAA0355	9710	broad.mit.edu	37	19	34832392	34832392	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:34832392C>A	ENST00000299505.6	+	10	2426	c.1553C>A	c.(1552-1554)gCt>gAt	p.A518D		NM_014686.3	NP_055501.2	O15063	K0355_HUMAN	KIAA0355	518										breast(1)|endometrium(7)|kidney(1)|large_intestine(4)|lung(15)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	41	Esophageal squamous(110;0.162)					GGCAACCAGGCTGACCTGCCT	0.433000													55	57					1.27862e-28	1.68047e-28	1	1	0
GRM6	2916	broad.mit.edu	37	5	178410002	178410002	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:178410002G>A	ENST00000231188.5	-	9	2523	c.2345C>T	c.(2344-2346)gCc>gTc	p.A782V	RP11-281O15.4_ENST00000519491.1_RNA|GRM6_ENST00000517717.1_Missense_Mutation_p.A782V	NM_000843.3	NP_000834.2	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6	782					detection of visible light|visual perception	integral to plasma membrane				NS(2)|breast(4)|endometrium(9)|large_intestine(12)|lung(21)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	55	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		GATGGGCTTGGCCTCGTTGAA	0.587000													78	26					0	0	1	0	0
ATRNL1	26033	broad.mit.edu	37	10	116975551	116975551	+	Missense_Mutation	SNP	A	A	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:116975551A>T	ENST00000355044.3	+	9	1571	c.1445A>T	c.(1444-1446)tAt>tTt	p.Y482F		NM_207303.2	NP_997186.1	Q5VV63	ATRN1_HUMAN	attractin-like 1	482						integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(11)|liver(2)|lung(44)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		AAGTCCATTTATGTTCATGGA	0.363000													7	27					0	0	1	0	0
CTBP2	1488	broad.mit.edu	37	10	126683152	126683152	+	Silent	SNP	G	G	A	rs78653489		TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:126683152G>A	ENST00000309035.6	-	5	2416	c.2286C>T	c.(2284-2286)ggC>ggT	p.G762G	CTBP2_ENST00000334808.6_Silent_p.G290G|CTBP2_ENST00000531469.1_Silent_p.G222G|CTBP2_ENST00000494626.2_Silent_p.G222G|CTBP2_ENST00000337195.5_Silent_p.G222G|CTBP2_ENST00000411419.2_Silent_p.G222G	NM_022802.2	NP_073713.2	P56545	CTBP2_HUMAN	C-terminal binding protein 2	222					negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent|viral genome replication|white fat cell differentiation	cell junction|synapse|transcriptional repressor complex	NAD binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25		all_lung(145;0.0132)|Lung NSC(174;0.0193)|all_neural(114;0.116)|Colorectal(57;0.173)		Colorectal(40;0.00572)|COAD - Colon adenocarcinoma(40;0.0127)|GBM - Glioblastoma multiforme(135;0.147)		CCCTCTGCACGCCCAGGGACC	0.552000													14	94					0	0	1	0	0
LSAMP	4045	broad.mit.edu	37	3	115805390	115805390	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:115805390C>A	ENST00000490035.2	-	2	668	c.169G>T	c.(169-171)Gac>Tac	p.D57Y	LSAMP_ENST00000539563.1_Missense_Mutation_p.D54Y	NM_002338.3	NP_002329.2	Q13449	LSAMP_HUMAN	limbic system-associated membrane protein		Ig-like C2-type 1.				cell adhesion|nervous system development	anchored to membrane|plasma membrane				NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|kidney(1)|large_intestine(4)|lung(14)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	31		all_cancers(1;0.00189)|all_epithelial(1;0.0366)|Myeloproliferative disorder(1037;0.17)|all_neural(597;0.208)|Lung NSC(201;0.215)		GBM - Glioblastoma multiforme(114;0.00117)|LUSC - Lung squamous cell carcinoma(41;0.0407)|Lung(219;0.152)		GAGTTCTTGTCTTCTACAACG	0.458000													40	27					1.76056e-25	2.2496e-25	1	1	0
SOX8	30812	broad.mit.edu	37	16	1034810	1034810	+	Silent	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:1034810G>T	ENST00000293894.3	+	3	880	c.765G>T	c.(763-765)ggG>ggT	p.G255G		NM_014587.3	NP_055402.2	P57073	SOX8_HUMAN	SRY (sex determining region Y)-box 8	255					adipose tissue development|enteric nervous system development|fat cell differentiation|in utero embryonic development|metanephric nephron tubule formation|morphogenesis of a branching epithelium|negative regulation of apoptosis|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-dependent|neural crest cell migration|oligodendrocyte differentiation|osteoblast differentiation|peripheral nervous system development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of gliogenesis|positive regulation of osteoblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of hormone levels|renal vesicle induction|retinal rod cell differentiation|Sertoli cell development|signal transduction|spermatogenesis|ureter morphogenesis	cytoplasm|nucleus				central_nervous_system(1)|kidney(1)|lung(5)|prostate(2)|skin(1)	10		Hepatocellular(780;0.00308)				TGGACAGCGGGCGCCAGAACA	0.682000													28	21					3.65163e-15	4.22578e-15	1	1	0
NEK10	152110	broad.mit.edu	37	3	27326389	27326389	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:27326389G>T	ENST00000429845.2	-	22	2215	c.1853C>A	c.(1852-1854)tCt>tAt	p.S618Y	NEK10_ENST00000341435.5_Missense_Mutation_p.S618Y|NEK10_ENST00000357467.2_Missense_Mutation_p.S15Y			Q6ZWH5	NEK10_HUMAN	NIMA-related kinase 10	618	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						TTCCTTCAAAGAACTGAAATG	0.313000													25	131					4.22769e-11	4.67673e-11	1	1	0
CEP170B	283638	broad.mit.edu	37	14	105354104	105354104	+	Silent	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:105354104G>C	ENST00000453495.1	+	12	3759	c.3531G>C	c.(3529-3531)cgG>cgC	p.R1177R	CEP170B_ENST00000418279.1_Silent_p.R1106R|CEP170B_ENST00000414716.3_Silent_p.R1176R|CEP170B_ENST00000556508.1_Silent_p.R1106R					centrosomal protein 170B																		CCCGGAAGCGGGCCGGCTCCT	0.697000													10	6					0	0	1	0	0
ABCB1	5243	broad.mit.edu	37	7	87179515	87179515	+	Missense_Mutation	SNP	T	T	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:87179515T>C	ENST00000265724.3	-	13	1739	c.1322A>G	c.(1321-1323)cAg>cGg	p.Q441R	ABCB1_ENST00000543898.1_Missense_Mutation_p.Q377R	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	441	ABC transporter 1.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	ATAGAGCCTCTGCATCAGCTG	0.552000													31	47					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25449350	25449350	+	RNA	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr15:25449350C>A	ENST00000424208.1	+	0	2242				SNHG14_ENST00000424333.1_RNA	NR_003305.1																						GTATTGGGGCCACTGGCCCCA	0.622000													14	16					0.00244969	0.00246758	1	1	0
EIF3J	8669	broad.mit.edu	37	15	44829435	44829435	+	Splice_Site	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr15:44829435G>C	ENST00000261868.5	+	1	181	c.43G>C	c.(43-45)Gac>Cac	p.D15H	EIF3J_ENST00000535391.1_Splice_Site_p.D15H|EIF3J_ENST00000424492.3_Splice_Site_p.D15H	NM_003758.2	NP_003749.2	O75822	EIF3J_HUMAN	eukaryotic translation initiation factor 3, subunit J	15	Sufficient for interaction with EIF3B.					cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			endometrium(1)|large_intestine(5)|liver(2)|skin(1)	9		all_cancers(109;2.81e-14)|all_epithelial(112;2.8e-12)|Lung NSC(122;1.66e-07)|all_lung(180;1.47e-06)|Melanoma(134;0.0122)		all cancers(107;3.13e-20)|GBM - Glioblastoma multiforme(94;9.81e-07)|COAD - Colon adenocarcinoma(120;0.0754)|Colorectal(105;0.0758)		GGACTCCTGGGGTGAGGAGAA	0.711000													8	10					0	0	1	0	0
HTR1F	3355	broad.mit.edu	37	3	88039908	88039908	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:88039908C>A	ENST00000319595.4	+	1	63	c.9C>A	c.(7-9)ttC>ttA	p.F3L		NM_000866.3	NP_000857.1	P30939	5HT1F_HUMAN	5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled	3					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	serotonin binding|serotonin receptor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(12)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	25	all_cancers(8;0.147)	Lung NSC(201;0.0283)		LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00664)	Eletriptan(DB00216)|Naratriptan(DB00952)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Zolmitriptan(DB00315)	AAATGGATTTCTTAAATTCAT	0.368000													38	65					6.97489e-18	8.35171e-18	1	1	0
SORBS1	10580	broad.mit.edu	37	10	97096652	97096652	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:97096652G>T	ENST00000371247.2	-	30	3454	c.3265C>A	c.(3265-3267)Caa>Aaa	p.Q1089K	SORBS1_ENST00000353505.5_Intron|SORBS1_ENST00000361941.3_Missense_Mutation_p.Q1089K|SORBS1_ENST00000277982.5_Intron|SORBS1_ENST00000393949.1_Intron|SORBS1_ENST00000371227.4_Missense_Mutation_p.Q1043K|SORBS1_ENST00000371249.2_Intron|SORBS1_ENST00000371245.3_Intron|SORBS1_ENST00000354106.3_Intron|SORBS1_ENST00000607232.1_Intron|SORBS1_ENST00000371241.1_Intron|SORBS1_ENST00000347291.4_Intron|SORBS1_ENST00000371239.1_Intron|SORBS1_ENST00000371246.2_Intron|SORBS1_ENST00000306402.6_Intron			Q9BX66	SRBS1_HUMAN	sorbin and SH3 domain containing 1	1089					focal adhesion assembly|glucose transport|insulin receptor signaling pathway|muscle contraction|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|stress fiber assembly	centrosome|cytosol|focal adhesion|membrane raft|nucleus|stress fiber|zonula adherens	actin binding|insulin receptor binding|SH3/SH2 adaptor activity			NS(1)|breast(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(19)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	42		Colorectal(252;0.0429)		Epithelial(162;1.7e-06)|all cancers(201;6.52e-05)		AAGCTATCTTGGTGGATGCCT	0.562000													39	19					2.00842e-17	2.39449e-17	1	1	0
CBX1	10951	broad.mit.edu	37	17	46152410	46152410	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:46152410C>G	ENST00000393408.3	-	4	851	c.371G>C	c.(370-372)gGa>gCa	p.G124A	CBX1_ENST00000225603.4_Missense_Mutation_p.G124A|CBX1_ENST00000495350.1_Missense_Mutation_p.G124A	NM_006807.4	NP_006798.1	P83916	CBX1_HUMAN	chromobox homolog 1	124	Chromo 2; shadow subtype.					nuclear heterochromatin|nucleoplasm|spindle	chromatin binding|enzyme binding			breast(1)|central_nervous_system(1)|kidney(1)|prostate(1)	4						GTCTGTAGCTCCAATAATCCG	0.453000													87	87					0	0	1	0	0
CCDC105	126402	broad.mit.edu	37	19	15121757	15121757	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:15121757G>A	ENST00000292574.3	+	1	202	c.120G>A	c.(118-120)ggG>ggA	p.G40G		NM_173482.2	NP_775753.2	Q8IYK2	CC105_HUMAN	coiled-coil domain containing 105	40					microtubule cytoskeleton organization	microtubule				NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(4)|skin(2)	23						ATCGCTGCGGGCAGGAGGCGG	0.711000													5	12					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578455	7578455	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:7578455C>G	ENST00000420246.2	-	5	607	c.475G>C	c.(475-477)Gcc>Ccc	p.A159P	TP53_ENST00000413465.2_Missense_Mutation_p.A159P|TP53_ENST00000445888.2_Missense_Mutation_p.A159P|TP53_ENST00000359597.4_Missense_Mutation_p.A159P|TP53_ENST00000269305.4_Missense_Mutation_p.A159P|TP53_ENST00000455263.2_Missense_Mutation_p.A159P	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	159	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		A -> D (in sporadic cancers; somatic mutation).|A -> F (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|A -> G (in sporadic cancers; somatic mutation).|A -> P (in sporadic cancers; somatic mutation).|A -> S (in sporadic cancers; somatic mutation).|A -> T (in sporadic cancers; somatic mutation).|A -> V (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.A159P(19)|p.0?(8)|p.A159T(7)|p.R158fs(6)|p.R158fs*11(6)|p.A159fs*11(4)|p.A159S(4)|p.R65fs(2)|p.A27P(2)|p.R158_A159delRA(2)|p.R156_I162delRVRAMAI(2)|p.V157fs*9(2)|p.R26fs(2)|p.A66P(2)|p.V157_C176del20(1)|p.R156_A161delRVRAMA(1)|p.P151_V173del23(1)|p.R156fs*18(1)|p.R26fs*11(1)|p.R156_A161del(1)|p.R158_A159insXX(1)|p.V157_M160delVRAM(1)|p.S149fs*72(1)|p.A159fs*21(1)|p.T155_A161delTRVRAMA(1)|p.R65fs*11(1)|p.R156fs*20(1)|p.V157_I162delVRAMAI(1)|p.A159_Q167delAMAIYKQSQ(1)|p.V157fs*21(1)|p.R158fs*8(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATGGCCATGGCGCGGACGCGG	0.627000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			52	9					0	0	1	0	0
RGS19	10287	broad.mit.edu	37	20	62705211	62705211	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:62705211C>A	ENST00000395042.1	-	6	915	c.649G>T	c.(649-651)Gcc>Tcc	p.A217S	RGS19_ENST00000332298.5_Missense_Mutation_p.A217S	NM_005873.2	NP_005864.1	P49795	RGS19_HUMAN	regulator of G-protein signaling 19	217	Interaction with GIPC.				autophagy|G-protein coupled receptor protein signaling pathway|negative regulation of signal transduction|small GTPase mediated signal transduction	Golgi apparatus|membrane fraction|plasma membrane	GTPase activator activity|protein binding|signal transducer activity			lung(1)|prostate(1)|skin(1)	3	all_cancers(38;3.45e-11)|all_epithelial(29;9.12e-13)|Lung NSC(23;2e-09)|all_lung(23;6.77e-09)					GCGGCCTAGGCCTCGGAGGAG	0.667000													68	33					9.21137e-24	1.15299e-23	1	1	0
AKAP8L	26993	broad.mit.edu	37	19	15491178	15491178	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:15491178C>G	ENST00000397410.5	-	14	1826	c.1696G>C	c.(1696-1698)Gcc>Ccc	p.A566P	AC005785.2_ENST00000597164.2_RNA|AKAP8L_ENST00000595465.2_Missense_Mutation_p.A505P	NM_014371.2	NP_055186.2	Q9ULX6	AKP8L_HUMAN	A kinase (PRKA) anchor protein 8-like					EEEKEQEEAEGGALDEGAQGEAAGISEGAEGVPAQPPVPPE PA -> RRRRSRRRLRAVPWTRGRRAKRQGFRRAQRACRRS LPCPQSQP (in Ref. 3; AAF86048).		cytoplasm|nuclear matrix	DEAD/H-box RNA helicase binding|DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|kidney(2)|lung(1)|ovary(1)|prostate(1)|urinary_tract(1)	11						TCGTCCAGGGCACCGCCCTCA	0.741000													7	7					0	0	1	0	0
RNASE9	390443	broad.mit.edu	37	14	21024720	21024720	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:21024720C>T	ENST00000557068.1	-	4	2234	c.509G>A	c.(508-510)tGg>tAg	p.W170*	RNASE9_ENST00000555230.1_Nonsense_Mutation_p.W170*|RNASE9_ENST00000553706.1_Nonsense_Mutation_p.W175*|RNASE9_ENST00000429244.2_Nonsense_Mutation_p.W170*|RNASE9_ENST00000338904.3_Nonsense_Mutation_p.W170*|RNASE9_ENST00000553541.1_Nonsense_Mutation_p.W170*|RNASE9_ENST00000557209.1_Nonsense_Mutation_p.W175*|RNASE9_ENST00000554964.1_Nonsense_Mutation_p.W170*|RNASE9_ENST00000404716.3_Nonsense_Mutation_p.W175*|RNASE9_ENST00000556208.1_Nonsense_Mutation_p.W175*			P60153	RNAS9_HUMAN	ribonuclease, RNase A family, 9 (non-active)	170						extracellular region	nucleic acid binding|pancreatic ribonuclease activity			haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|ovary(2)|urinary_tract(1)	8	all_cancers(95;0.00238)		Epithelial(56;3.32e-06)|all cancers(55;2.46e-05)	GBM - Glioblastoma multiforme(265;0.0141)		TTCATTTTGCCATGAACAAGT	0.383000													14	17					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2944710	2944710	+	Silent	SNP	A	A	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr8:2944710A>T	ENST00000602557.1	-	50	7941	c.7386T>A	c.(7384-7386)ccT>ccA	p.P2462P	CSMD1_ENST00000520002.1_Silent_p.P2462P|CSMD1_ENST00000537824.1_Silent_p.P2461P|CSMD1_ENST00000602723.1_Silent_p.P2462P|CSMD1_ENST00000400186.3_Silent_p.P2462P|CSMD1_ENST00000542608.1_Silent_p.P2461P			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	2462	Sushi 14.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TTCGGTATCCAGGCTTGCAAA	0.522000													56	3					0	0	1	0	0
CSPG4	1464	broad.mit.edu	37	15	75981330	75981330	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr15:75981330G>A	ENST00000308508.5	-	3	2168	c.2076C>T	c.(2074-2076)gcC>gcT	p.A692A		NM_001897.4	NP_001888.2	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4	692	Gly/Ser-rich (glycosaminoglycan attachment domain).|Interaction with COL5A1 (By similarity).|Interaction with COL6A2 (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			breast(1)|cervix(2)|endometrium(5)|kidney(5)|large_intestine(3)|liver(2)|lung(18)|ovary(2)|pancreas(2)|prostate(4)|skin(4)	48						CCTGCCCCACGGCATTGGTCT	0.662000													57	84					0	0	1	0	0
CLEC18B	497190	broad.mit.edu	37	16	74452026	74452026	+	Silent	SNP	T	T	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:74452026T>A	ENST00000339953.5	-	3	508	c.387A>T	c.(385-387)gcA>gcT	p.A129A		NM_001011880.2	NP_001011880.2	Q6UXF7	CL18B_HUMAN	C-type lectin domain family 18, member B	129	SCP.					extracellular region	sugar binding			endometrium(3)|kidney(9)|large_intestine(3)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27						GCTGCCCCTCTGCAAACCACA	0.662000													29	36					0	0	1	0	0
HIST2H3D	653604	broad.mit.edu	37	1	149785176	149785176	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:149785176G>A	ENST00000331491.1	-	1	60	c.61C>T	c.(61-63)Ctg>Ttg	p.L21L		NM_001123375.2	NP_001116847.1	Q71DI3	H32_HUMAN	histone cluster 2, H3d	21					blood coagulation|nucleosome assembly	nucleoplasm|nucleosome	DNA binding|protein binding			biliary_tract(1)|endometrium(1)|large_intestine(1)|liver(1)|lung(3)	7						TTGGTAGCCAGCTGCTTCCTC	0.667000													21	75					0	0	1	0	0
ARVCF	421	broad.mit.edu	37	22	19965049	19965049	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr22:19965049G>T	ENST00000263207.3	-	9	2050	c.1759C>A	c.(1759-1761)Ccc>Acc	p.P587T	ARVCF_ENST00000406522.1_Missense_Mutation_p.P524T|ARVCF_ENST00000406259.1_Missense_Mutation_p.P587T|ARVCF_ENST00000401994.1_Missense_Mutation_p.P524T|ARVCF_ENST00000344269.3_Missense_Mutation_p.P524T	NM_001670.2	NP_001661.1	O00192	ARVC_HUMAN	armadillo repeat gene deleted in velocardiofacial syndrome	587					cell adhesion|multicellular organismal development		protein binding			NS(1)|cervix(1)|endometrium(3)|liver(1)|lung(4)|prostate(1)|urinary_tract(2)	13	Colorectal(54;0.0993)					TCGGCCCCGGGCACCTCCTTG	0.677000													62	67					2.17656e-39	2.99616e-39	1	1	0
NFATC2	4773	broad.mit.edu	37	20	50048713	50048713	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:50048713G>A	ENST00000371564.3	-	9	2832	c.2613C>T	c.(2611-2613)agC>agT	p.S871S	NFATC2_ENST00000414705.1_Silent_p.S851S|NFATC2_ENST00000396009.3_Silent_p.S871S|NFATC2_ENST00000609507.1_Silent_p.S652S|NFATC2_ENST00000610033.1_Silent_p.S652S|NFATC2_ENST00000609943.1_Silent_p.S851S	NM_001258296.1|NM_012340.4	NP_001245225.1|NP_036472.2	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	871					B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity		EWSR1/NFATC2(9)	breast(2)|endometrium(7)|kidney(1)|large_intestine(7)|lung(25)|ovary(2)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	53	Hepatocellular(150;0.248)					CGGCTCTTTGGCTCGTGGCAT	0.592000													51	117					0	0	1	0	0
C11orf58	10944	broad.mit.edu	37	11	16776487	16776487	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:16776487C>A	ENST00000228136.4	+	5	766	c.388C>A	c.(388-390)Cct>Act	p.P130T	C11orf58_ENST00000422258.2_Missense_Mutation_p.P86T|C11orf58_ENST00000525684.1_3'UTR			O00193	SMAP_HUMAN	chromosome 11 open reading frame 58	130	Asp-rich.									NS(1)|endometrium(1)|lung(3)|prostate(1)|skin(1)	7						tTCACCTGATCCTGAAAGTCC	0.438000													29	3					1.2476e-16	1.47153e-16	1	1	0
RNF126P1	376412	broad.mit.edu	37	17	55123481	55123481	+	RNA	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:55123481C>G	ENST00000567452.1	+	0	643					NR_002818.2																						ACGGGCCCCCCACCGGCAGAT	0.612000													6	2					0	0	1	0	0
KL	9365	broad.mit.edu	37	13	33591101	33591101	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr13:33591101C>G	ENST00000380099.3	+	1	531	c.523C>G	c.(523-525)Cgc>Ggc	p.R175G	KL_ENST00000487852.1_3'UTR|KL_ENST00000426690.2_Intron	NM_004795.3	NP_004786.2	Q9UEF7	KLOT_HUMAN	klotho	175	Glycosyl hydrolase-1 1.				aging|carbohydrate metabolic process|insulin receptor signaling pathway|positive regulation of bone mineralization	extracellular space|integral to membrane|integral to plasma membrane|membrane fraction|soluble fraction	beta-glucosidase activity|beta-glucuronidase activity|cation binding|fibroblast growth factor binding|hormone activity|signal transducer activity|vitamin D binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(10)|lung(14)|ovary(2)|skin(5)	41	all_epithelial(80;0.133)	Ovarian(182;1.78e-06)|Breast(139;4.08e-05)|Hepatocellular(188;0.00886)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;7.13e-230)|all cancers(112;1.33e-165)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-113)|Epithelial(112;3.79e-112)|Lung(94;8.52e-27)|LUSC - Lung squamous cell carcinoma(192;1.4e-13)|Kidney(163;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(186;5.63e-08)|BRCA - Breast invasive adenocarcinoma(63;1.41e-05)		CTACTACCGGCGCCTGCTGGA	0.726000													11	16					0	0	1	0	0
MYH4	4622	broad.mit.edu	37	17	10353854	10353854	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:10353854G>C	ENST00000255381.2	-	30	4207	c.4097C>G	c.(4096-4098)tCc>tGc	p.S1366C	RP11-799N11.1_ENST00000399342.2_RNA|CTC-297N7.11_ENST00000587182.2_RNA|RP11-799N11.1_ENST00000581304.1_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	1366					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						GTTGGCCTTGGACATTCCCCT	0.602000													102	9					0	0	1	0	0
IL23A	51561	broad.mit.edu	37	12	56733306	56733306	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:56733306C>T	ENST00000228534.4	+	2	425	c.259C>T	c.(259-261)Cag>Tag	p.Q87*		NM_016584.2	NP_057668.1	Q9NPF7	IL23A_HUMAN	interleukin 23, alpha subunit p19	87					defense response to Gram-negative bacterium|inflammatory response|innate immune response|negative regulation of interleukin-10 production|positive regulation of activated T cell proliferation|positive regulation of activation of JAK2 kinase activity|positive regulation of defense response to virus by host|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-17 production|positive regulation of memory T cell differentiation|positive regulation of natural killer cell proliferation|positive regulation of NF-kappaB import into nucleus|positive regulation of NK T cell activation|positive regulation of NK T cell proliferation|positive regulation of osteoclast differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat4 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|regulation of tyrosine phosphorylation of Stat1 protein|response to virus|tissue remodeling	interleukin-23 complex	cytokine activity			kidney(1)|lung(2)|prostate(1)|upper_aerodigestive_tract(1)	5						GGACAACAGTCAGGTACCACT	0.493000													25	28					0	0	1	0	0
LMOD1	25802	broad.mit.edu	37	1	201868633	201868633	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:201868633G>A	ENST00000367288.4	-	2	1754	c.1508C>T	c.(1507-1509)gCc>gTc	p.A503V	RP11-307B6.3_ENST00000414927.1_RNA|RP11-307B6.3_ENST00000458139.1_RNA	NM_012134.2	NP_036266.2	P29536	LMOD1_HUMAN	leiomodin 1 (smooth muscle)	503					muscle contraction	cytoskeleton|cytosol|membrane fraction	tropomyosin binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|liver(1)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26						CTTAGCCACGGCCCCGGCCTT	0.582000													23	30					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158641934	158641934	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:158641934C>A	ENST00000368147.4	-	11	1583	c.1403G>T	c.(1402-1404)cGt>cTt	p.R468L		NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)						actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton	p.R468H(1)		NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					CTGACGATGACGCTCGTCCCA	0.438000													64	52					7.73544e-29	1.01908e-28	1	1	0
IZUMO2	126123	broad.mit.edu	37	19	50657922	50657922	+	Silent	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:50657922C>T	ENST00000293405.3	-	6	558	c.558G>A	c.(556-558)caG>caA	p.Q186Q		NM_152358.2	NP_689571.2	Q6UXV1	IZUM2_HUMAN	IZUMO family member 2	186						integral to membrane				cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(1)	7						CCAACAGCGCCTGGTTCCTCG	0.622000													21	78					0	0	1	0	0
PITPNM2	57605	broad.mit.edu	37	12	123481053	123481053	+	Silent	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:123481053C>A	ENST00000280562.5	-	12	1939	c.1734G>T	c.(1732-1734)gtG>gtT	p.V578V	PITPNM2_ENST00000392428.1_Silent_p.V299V|PITPNM2_ENST00000542749.1_Silent_p.V578V|PITPNM2_ENST00000320201.4_Silent_p.V578V			Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein, membrane-associated 2	578					metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			NS(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	39	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		GACTCTCAGACACCGGCTGGT	0.652000													23	48					1.1804e-14	1.36029e-14	1	1	0
TMEM131	23505	broad.mit.edu	37	2	98422040	98422040	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:98422040C>T	ENST00000186436.5	-	20	2410	c.2182G>A	c.(2182-2184)Gac>Aac	p.D728N		NM_015348.1	NP_056163.1	Q92545	TM131_HUMAN	transmembrane protein 131	728						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(4)|prostate(1)|skin(1)|stomach(1)	57						GGCTCCAAGTCTTCCTTATTG	0.343000													75	102					0	0	1	0	0
OR8K5	219453	broad.mit.edu	37	11	55927213	55927213	+	Missense_Mutation	SNP	T	T	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:55927213T>G	ENST00000313447.1	-	1	580	c.581A>C	c.(580-582)gAa>gCa	p.E194A		NM_001004058.2	NP_001004058.2	Q8NH50	OR8K5_HUMAN	olfactory receptor, family 8, subfamily K, member 5	194					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|lung(24)|ovary(2)|pancreas(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	34	Esophageal squamous(21;0.00693)	Lung NSC(402;0.197)|all_epithelial(135;0.236)				CAATTCTATTTCCTGTGCATT	0.333000													7	61					0	0	1	0	0
OR4K17	390436	broad.mit.edu	37	14	20586121	20586121	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:20586121C>G	ENST00000315543.4	+	1	556	c.556C>G	c.(556-558)Cac>Gac	p.H186D		NM_001004715.1	NP_001004715.1	Q8NGC6	OR4KH_HUMAN	olfactory receptor, family 4, subfamily K, member 17	158					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.H186Y(1)		kidney(1)|large_intestine(4)|lung(12)|pancreas(1)|skin(3)	21	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.77e-06)	GBM - Glioblastoma multiforme(265;0.0144)		GGGTCTCCTTCACTCAGGGTT	0.453000													60	94					0	0	1	0	0
PXDN	7837	broad.mit.edu	37	2	1652481	1652481	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:1652481G>T	ENST00000252804.4	-	17	3121	c.3071C>A	c.(3070-3072)gCg>gAg	p.A1024E		NM_012293.1	NP_036425.1	Q92626	PXDN_HUMAN	peroxidasin homolog (Drosophila)	1024					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			breast(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(24)|lung(48)|ovary(3)|pancreas(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	112	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		CTGGATCTCCGCACCCACGAT	0.622000													11	0					3.86212e-05	3.94794e-05	1	1	0
CCT5	22948	broad.mit.edu	37	5	10254301	10254301	+	Silent	SNP	A	A	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:10254301A>C	ENST00000280326.4	+	2	570	c.150A>C	c.(148-150)acA>acC	p.T50T	CCT5_ENST00000515390.1_Silent_p.T50T|CCT5_ENST00000515676.1_Silent_p.T12T|CCT5_ENST00000506600.1_Silent_p.T12T|CCT5_ENST00000503026.1_Silent_p.T29T	NM_012073.3	NP_036205.1	P48643	TCPE_HUMAN	chaperonin containing TCP1, subunit 5 (epsilon)	50					'de novo' posttranslational protein folding|response to virus	microtubule organizing center|nucleolus	ATP binding|unfolded protein binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(2)	26						CAATGAGAACATCACTTGGAC	0.328000													22	33					0	0	1	0	0
HSD17B1	3292	broad.mit.edu	37	17	40704977	40704977	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:40704977C>G	ENST00000585807.1	+	1	3746	c.26C>G	c.(25-27)aCc>aGc	p.T9S	RP11-400F19.8_ENST00000585572.1_RNA|HSD17B1_ENST00000225929.5_Missense_Mutation_p.T9S|RP11-400F19.6_ENST00000590513.1_RNA	NM_000413.2	NP_000404.2	P14061	DHB1_HUMAN	hydroxysteroid (17-beta) dehydrogenase 1	9					estrogen biosynthetic process	cytosol	binding|estradiol 17-beta-dehydrogenase activity			NS(1)|endometrium(1)|kidney(1)|lung(2)	5		all_cancers(22;5.59e-08)|all_epithelial(22;7e-07)|Ovarian(249;0.0261)		BRCA - Breast invasive adenocarcinoma(366;0.129)	NADH(DB00157)	GTGCTCATCACCGGCTGTTCC	0.647000													55	4					0	0	1	0	0
RPS6KC1	26750	broad.mit.edu	37	1	213224846	213224846	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:213224846G>T	ENST00000366960.3	+	1	250	c.100G>T	c.(100-102)Gcc>Tcc	p.A34S	RPS6KC1_ENST00000543470.1_5'UTR|RPS6KC1_ENST00000366959.3_Missense_Mutation_p.A34S|RPS6KC1_ENST00000543354.1_5'UTR	NM_012424.3	NP_036556.2	Q96S38	KS6C1_HUMAN	ribosomal protein S6 kinase, 52kDa, polypeptide 1	34	PX.				cell communication|signal transduction	early endosome|membrane	ATP binding|phosphatidylinositol binding|protein binding|protein serine/threonine kinase activity			breast(1)|endometrium(6)|kidney(4)|large_intestine(8)|liver(2)|lung(15)|ovary(3)|prostate(1)|urinary_tract(3)	43				OV - Ovarian serous cystadenocarcinoma(81;0.00705)|all cancers(67;0.016)|GBM - Glioblastoma multiforme(131;0.0663)|Epithelial(68;0.145)		TAAGGTCACCGCCCGGGTGAG	0.627000													12	24					0.00136819	0.00138831	1	1	0
MARVELD3	91862	broad.mit.edu	37	16	71668682	71668682	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:71668682G>T	ENST00000268485.3	+	3	1226	c.1182G>T	c.(1180-1182)aaG>aaT	p.K394N	MARVELD3_ENST00000565261.1_Intron|MARVELD3_ENST00000299952.4_Intron	NM_052858.4	NP_443090.4	Q96A59	MALD3_HUMAN	MARVEL domain containing 3	394						integral to membrane				NS(1)|endometrium(3)|large_intestine(5)|lung(6)|skin(2)	17		Ovarian(137;0.125)				TAAAAGAGAAGCCAGCAGAAA	0.493000													37	43					1.07637e-12	1.21256e-12	1	1	0
MMP2	4313	broad.mit.edu	37	16	55523725	55523725	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:55523725G>A	ENST00000219070.4	+	7	1678	c.1169G>A	c.(1168-1170)tGc>tAc	p.C390Y	MMP2_ENST00000570308.1_Missense_Mutation_p.C314Y|MMP2_ENST00000437642.2_Missense_Mutation_p.C340Y|MMP2_ENST00000543485.1_Missense_Mutation_p.C314Y	NM_004530.4	NP_004521.1	P08253	MMP2_HUMAN	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	390	Collagen-binding.|Fibronectin type-II 3.				angiogenesis|collagen catabolic process|proteolysis	extracellular space|membrane|nucleus|proteinaceous extracellular matrix	metalloendopeptidase activity|protein binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(12)|liver(2)|lung(23)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	58		Renal(780;0.00183)|Breast(268;0.00354)|Hepatocellular(780;0.00826)|all_neural(199;0.0189)		UCEC - Uterine corpus endometrioid carcinoma (183;0.0185)|all cancers(182;7.16e-45)|Epithelial(162;5.26e-37)|GBM - Glioblastoma multiforme(240;9e-08)|Kidney(780;0.00227)|BRCA - Breast invasive adenocarcinoma(181;0.00786)	Marimastat(DB00786)|Sulindac(DB00605)	TGGGGCTTCTGCCCTGACCAA	0.572000													25	37					0	0	1	0	0
DOCK2	1794	broad.mit.edu	37	5	169101351	169101351	+	Silent	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:169101351G>C	ENST00000256935.8	+	6	452	c.372G>C	c.(370-372)ctG>ctC	p.L124L		NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	124					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TGTACGATCTGATGGAGTGGA	0.478000													50	23					0	0	1	0	0
ZER1	10444	broad.mit.edu	37	9	131516169	131516169	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:131516169G>C	ENST00000291900.2	-	3	634	c.228C>G	c.(226-228)gaC>gaG	p.D76E	ZER1_ENST00000494461.1_5'UTR	NM_006336.2	NP_006327.2	Q7Z7L7	ZER1_HUMAN	zyg-11 related, cell cycle regulator	76					ATP hydrolysis coupled proton transport|regulation of ubiquitin-protein ligase activity	Cul2-RING ubiquitin ligase complex|vacuolar proton-transporting V-type ATPase, V1 domain	protein binding|proton-transporting ATPase activity, rotational mechanism|ubiquitin-protein ligase activity			endometrium(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|urinary_tract(1)	15						TGCTGCGGGGGTCCGAAAAGA	0.627000													5	10					0	0	1	0	0
CDH5	1003	broad.mit.edu	37	16	66436895	66436895	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:66436895C>A	ENST00000341529.3	+	12	2326	c.2178C>A	c.(2176-2178)gaC>gaA	p.D726E	CDH5_ENST00000539168.1_Missense_Mutation_p.D165E	NM_001795.3	NP_001786.2	P33151	CADH5_HUMAN	cadherin 5, type 2 (vascular endothelium)	726					adherens junction organization|cell junction assembly|homophilic cell adhesion|regulation of establishment of cell polarity	integral to membrane|membrane fraction	beta-catenin binding|calcium ion binding|ion channel binding|receptor binding			central_nervous_system(1)|endometrium(3)|kidney(18)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	54		Ovarian(137;0.0955)		OV - Ovarian serous cystadenocarcinoma(108;0.107)		CCCCCTACGACACGCTGCACA	0.667000													23	23					3.5997e-14	4.13105e-14	1	1	0
SNX25	83891	broad.mit.edu	37	4	186188167	186188167	+	Missense_Mutation	SNP	A	A	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:186188167A>G	ENST00000504273.1	+	5	751	c.457A>G	c.(457-459)Aac>Gac	p.N153D	SNX25_ENST00000264694.8_Missense_Mutation_p.N153D			Q9H3E2	SNX25_HUMAN	sorting nexin 25	153	PXA.				cell communication|protein transport	endosome membrane	phosphatidylinositol binding|signal transducer activity			NS(1)|breast(4)|endometrium(2)|kidney(4)|large_intestine(8)|lung(13)|ovary(2)|pancreas(2)|prostate(2)|urinary_tract(2)	40		all_lung(41;1.03e-13)|Lung NSC(41;2.5e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00886)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;2.13e-24)|Epithelial(43;6.15e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.6e-11)|BRCA - Breast invasive adenocarcinoma(30;0.00013)|Colorectal(24;0.000165)|GBM - Glioblastoma multiforme(59;0.000357)|COAD - Colon adenocarcinoma(29;0.000887)|STAD - Stomach adenocarcinoma(60;0.00118)|LUSC - Lung squamous cell carcinoma(40;0.0129)|READ - Rectum adenocarcinoma(43;0.228)		AGATTACATTAACCAAATGCT	0.453000													37	65					0	0	1	0	0
DSC2	1824	broad.mit.edu	37	18	28669557	28669557	+	Splice_Site	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr18:28669557C>G	ENST00000280904.6	-	5	918	c.475G>C	c.(475-477)Gtt>Ctt	p.V159L	DSC2_ENST00000251081.6_Splice_Site_p.V159L	NM_024422.3	NP_077740.1	Q02487	DSC2_HUMAN	desmocollin 2	159	Cadherin 1.				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)	21			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			TCAGATTGAACCTAGAAAGTA	0.328000													15	20					0	0	1	0	0
XPO4	64328	broad.mit.edu	37	13	21374421	21374421	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr13:21374421C>T	ENST00000400602.2	-	15	2056	c.2021G>A	c.(2020-2022)gGt>gAt	p.G674D	XPO4_ENST00000255305.6_Missense_Mutation_p.G674D	NM_022459.4	NP_071904.4	Q9C0E2	XPO4_HUMAN	exportin 4	674					protein transport	cytoplasm|nucleus	protein binding			breast(1)|endometrium(10)|kidney(4)|large_intestine(7)|lung(14)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	41		all_cancers(29;5.05e-24)|all_epithelial(30;5.56e-20)|all_lung(29;2.38e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000521)|Epithelial(112;0.000892)|OV - Ovarian serous cystadenocarcinoma(117;0.0148)|Lung(94;0.0189)|LUSC - Lung squamous cell carcinoma(192;0.0548)		CCACTGAGAACCCTCTGTATC	0.413000													40	45					0	0	1	0	0
SIDT1	54847	broad.mit.edu	37	3	113286403	113286403	+	Missense_Mutation	SNP	A	A	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:113286403A>G	ENST00000264852.4	+	3	1087	c.361A>G	c.(361-363)Aac>Gac	p.N121D	SIDT1_ENST00000393830.3_Missense_Mutation_p.N121D	NM_017699.2	NP_060169.2	Q9NXL6	SIDT1_HUMAN	SID1 transmembrane family, member 1	121						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(11)|liver(2)|lung(15)|ovary(3)|pancreas(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	50						GAGGAGCTACAACTATCAAGA	0.468000													59	101					0	0	1	0	0
ITGA5	3678	broad.mit.edu	37	12	54799117	54799117	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:54799117C>T	ENST00000293379.4	-	12	1319	c.1058G>A	c.(1057-1059)cGg>cAg	p.R353Q	RP11-753H16.5_ENST00000552785.1_RNA|RP11-753H16.3_ENST00000550474.1_RNA	NM_002205.2	NP_002196.2	P08648	ITA5_HUMAN	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	353					angiogenesis|axon guidance|blood coagulation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|wound healing, spreading of epidermal cells	alphav-beta3 integrin-vitronectin complex|integrin complex|ruffle	platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(11)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	34						GTCAGGGGTCCGATCCATGAG	0.652000													25	12					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9086125	9086125	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:9086125G>T	ENST00000397910.4	-	1	5893	c.5690C>A	c.(5689-5691)aCt>aAt	p.T1897N		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	1897	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CTCTGTGTAAGTCATGGAAGT	0.488000													25	109					2.27525e-19	2.74223e-19	1	1	0
SLCO1B3	28234	broad.mit.edu	37	12	21007999	21007999	+	Missense_Mutation	SNP	A	A	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:21007999A>T	ENST00000381545.3	+	4	341	c.122A>T	c.(121-123)aAa>aTa	p.K41I	SLCO1B3_ENST00000553473.1_Missense_Mutation_p.K41I|LST3_ENST00000540229.1_Missense_Mutation_p.K41I|SLCO1B7_ENST00000554957.1_Missense_Mutation_p.K41I|LST3_ENST00000381541.3_Missense_Mutation_p.K41I|SLCO1B3_ENST00000261196.2_Missense_Mutation_p.K41I	NM_019844.3	NP_062818.1	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family, member 1B3	41					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(23)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(2)	63	Esophageal squamous(101;0.149)					TATATTGCTAAAGCACTAGGT	0.318000													15	20					0	0	1	0	0
F10	2159	broad.mit.edu	37	13	113803477	113803477	+	Silent	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr13:113803477C>A	ENST00000375559.3	+	8	1151	c.1113C>A	c.(1111-1113)ggC>ggA	p.G371G	F10_ENST00000375551.3_3'UTR|F10_ENST00000409306.1_3'UTR	NM_000504.3	NP_000495.1	P00742	FA10_HUMAN	coagulation factor X	371	Peptidase S1.				blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|positive regulation of cell migration|positive regulation of protein kinase B signaling cascade|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen	calcium ion binding|phospholipid binding|protein binding|serine-type endopeptidase activity			endometrium(2)|large_intestine(4)|lung(10)|pancreas(1)|stomach(1)	18	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.113)|all_lung(25;0.0364)|all_epithelial(44;0.0373)|Lung NSC(25;0.128)|Breast(118;0.188)	all cancers(43;0.0805)|Epithelial(84;0.231)		Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Enoxaparin(DB01225)|Heparin(DB01109)|Menadione(DB00170)|Reteplase(DB00015)|Tenecteplase(DB00031)	ACGAGAAGGGCCGGCAGTCCA	0.637000													31	37					1.06801e-11	1.19583e-11	1	1	0
ASTL	431705	broad.mit.edu	37	2	96798412	96798412	+	Silent	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:96798412C>A	ENST00000342380.2	-	6	503	c.504G>T	c.(502-504)ctG>ctT	p.L168L		NM_001002036.3	NP_001002036.3	Q6HA08	ASTL_HUMAN	astacin-like metallo-endopeptidase (M12 family)	168					proteolysis		metalloendopeptidase activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(13)|ovary(1)|prostate(1)|skin(2)	30						ACGTGGGCGCCAGGGAGACCA	0.652000													46	88					5.34276e-22	6.64234e-22	1	1	0
GATA5	140628	broad.mit.edu	37	20	61050567	61050567	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:61050567C>T	ENST00000252997.2	-	2	72	c.11G>A	c.(10-12)aGc>aAc	p.S4N		NM_080473.4	NP_536721.1	Q9BWX5	GATA5_HUMAN	GATA binding protein 5	4					blood coagulation|intestinal epithelial cell differentiation|positive regulation of transcription from RNA polymerase II promoter	nucleoplasm	sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			kidney(1)|lung(3)|ovary(1)|stomach(1)	6	Breast(26;2.05e-08)		BRCA - Breast invasive adenocarcinoma(19;3.08e-06)			CAGCGCCAGGCTCTGGTACAT	0.716000													5	13					0	0	1	0	0
FSTL5	56884	broad.mit.edu	37	4	162463736	162463736	+	Silent	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:162463736C>T	ENST00000306100.5	-	9	1561	c.1125G>A	c.(1123-1125)ttG>ttA	p.L375L	FSTL5_ENST00000427802.2_Silent_p.L374L|FSTL5_ENST00000536695.1_Silent_p.L374L|FSTL5_ENST00000379164.4_Silent_p.L374L	NM_001128427.2|NM_020116.4	NP_001121899.1|NP_064501.2	Q8N475	FSTL5_HUMAN	follistatin-like 5	375	Ig-like 2.					extracellular region	calcium ion binding			central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(18)|lung(43)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	91	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		TTCCATTCTTCAACCAGCCAA	0.443000													42	59					0	0	1	0	0
GTF3C4	9329	broad.mit.edu	37	9	135553561	135553561	+	Silent	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:135553561G>C	ENST00000372146.4	+	2	1119	c.555G>C	c.(553-555)ctG>ctC	p.L185L	GTF3C4_ENST00000483873.2_Intron	NM_012204.2	NP_036336.2	Q9UKN8	TF3C4_HUMAN	general transcription factor IIIC, polypeptide 4, 90kDa	185					transcription initiation from RNA polymerase III promoter	transcription factor TFIIIC complex	DNA binding|enzyme activator activity|histone acetyltransferase activity|protein binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|skin(1)	20				OV - Ovarian serous cystadenocarcinoma(145;8.15e-07)|Epithelial(140;2.6e-05)		TGGCAGCACTGACCATGGACA	0.527000													56	51					0	0	1	0	0
ASTN1	460	broad.mit.edu	37	1	176863873	176863873	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:176863873G>A	ENST00000367654.3	-	17	3000	c.2789C>T	c.(2788-2790)aCc>aTc	p.T930I	ASTN1_ENST00000367657.3_Missense_Mutation_p.T922I|ASTN1_ENST00000424564.2_Missense_Mutation_p.T922I|ASTN1_ENST00000361833.2_Missense_Mutation_p.T922I	NM_004319.1	NP_004310.1	O14525	ASTN1_HUMAN	astrotactin 1						cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						CATGTGCTTGGTGCCGGAGTC	0.597000													36	142					0	0	1	0	0
IFNA4	3441	broad.mit.edu	37	9	21187497	21187497	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:21187497G>A	ENST00000421715.1	-	1	101	c.34C>T	c.(34-36)Ctg>Ttg	p.L12L		NM_021068.2	NP_066546.1	P05014	IFNA4_HUMAN	interferon, alpha 4	12					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|skin(2)|urinary_tract(1)	17				GBM - Glioblastoma multiforme(5;2.69e-202)|Lung(24;2.26e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		CTGAGCACCAGCACGGCCATC	0.502000													36	9					0	0	1	0	0
TMX4	56255	broad.mit.edu	37	20	7980425	7980425	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:7980425G>C	ENST00000246024.2	-	4	636	c.421C>G	c.(421-423)Caa>Gaa	p.Q141E	TMX4_ENST00000530935.1_5'UTR	NM_021156.2	NP_066979.2	Q9H1E5	TMX4_HUMAN	thioredoxin-related transmembrane protein 4	141					cell redox homeostasis|electron transport chain|transport	integral to membrane				endometrium(3)|large_intestine(2)|lung(11)|skin(1)	17						TCGACTGATTGCCATTTCTTC	0.403000													18	54					0	0	1	0	0
FAM175B	23172	broad.mit.edu	37	10	126519948	126519948	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:126519948C>T	ENST00000298492.5	+	8	739	c.694C>T	c.(694-696)Cga>Tga	p.R232*		NM_032182.3	NP_115558.3	Q15018	F175B_HUMAN	family with sequence similarity 175, member B	232						BRISC complex	polyubiquitin binding			NS(1)	1						AAAGAGTGAGCGAGTTGTTGA	0.378000													6	44					0	0	1	0	0
PTPRU	10076	broad.mit.edu	37	1	29638200	29638200	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:29638200G>C	ENST00000323874.8	+	22	3129	c.3019G>C	c.(3019-3021)Gac>Cac	p.D1007H	PTPRU_ENST00000460170.2_Missense_Mutation_p.D1007H|PTPRU_ENST00000356870.3_Missense_Mutation_p.D1007H|PTPRU_ENST00000373779.3_Missense_Mutation_p.D1001H|PTPRU_ENST00000415600.2_3'UTR|PTPRU_ENST00000345512.3_Missense_Mutation_p.D1011H|PTPRU_ENST00000428026.2_Missense_Mutation_p.D998H			Q92729	PTPRU_HUMAN	protein tyrosine phosphatase, receptor type, U	1011	Tyrosine-protein phosphatase 1.				canonical Wnt receptor signaling pathway|cell differentiation|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transmembrane receptor protein tyrosine phosphatase signaling pathway	cell-cell junction|integral to plasma membrane	beta-catenin binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(26)|ovary(1)|prostate(3)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	79		Colorectal(325;0.000399)|Lung NSC(340;0.00953)|all_lung(284;0.0112)|Breast(348;0.0126)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;6.99e-07)|COAD - Colon adenocarcinoma(152;3.18e-05)|STAD - Stomach adenocarcinoma(196;0.0234)|READ - Rectum adenocarcinoma(331;0.0686)|BRCA - Breast invasive adenocarcinoma(304;0.0871)		CACCTACGGGGACATCAAGAT	0.607000													45	88					0	0	1	0	0
NCF4	4689	broad.mit.edu	37	22	37266564	37266564	+	Silent	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr22:37266564C>G	ENST00000397147.4	+	5	634	c.450C>G	c.(448-450)ctC>ctG	p.L150L	NCF4_ENST00000248899.6_Silent_p.L150L	NM_013416.3	NP_038202.2	Q15080	NCF4_HUMAN	neutrophil cytosolic factor 4, 40kDa	150					cell communication|immune response|oxidation-reduction process	cytosol|NADPH oxidase complex	phosphatidylinositol binding|protein dimerization activity			cervix(1)|endometrium(4)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	16						TCCGCCGGCTCCGCCCGCGCA	0.617000													33	54					0	0	1	0	0
KRT2	3849	broad.mit.edu	37	12	53039197	53039197	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:53039197G>A	ENST00000309680.3	-	9	1547	c.1526C>T	c.(1525-1527)tCa>tTa	p.S509L		NM_000423.2	NP_000414.2	P35908	K22E_HUMAN	keratin 2	509	Tail.				keratinization|keratinocyte activation|keratinocyte migration|keratinocyte proliferation	Golgi apparatus|keratin filament	protein binding|structural constituent of cytoskeleton			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(18)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	32				BRCA - Breast invasive adenocarcinoma(357;0.19)		CACATTTGATGAAATGGTGCT	0.537000													68	68					0	0	1	0	0
COLGALT2	23127	broad.mit.edu	37	1	183933111	183933111	+	Silent	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:183933111C>A	ENST00000361927.4	-	6	1247	c.876G>T	c.(874-876)ctG>ctT	p.L292L	COLGALT2_ENST00000546159.1_Silent_p.L292L|COLGALT2_ENST00000367520.3_Silent_p.L29L	NM_015101.2	NP_055916.1			collagen beta(1-O)galactosyltransferase 2																		GGGGGATGGGCAGGTAGCCAT	0.522000													24	59					4.7796e-09	5.11306e-09	1	1	0
PUS3	83480	broad.mit.edu	37	11	125765537	125765537	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:125765537C>A	ENST00000227474.3	-	3	623	c.526G>T	c.(526-528)Gcc>Tcc	p.A176S	HYLS1_ENST00000425380.2_Intron|PUS3_ENST00000530811.1_Missense_Mutation_p.A176S|HYLS1_ENST00000356438.3_Intron|HYLS1_ENST00000526028.1_Intron	NM_001271985.1|NM_031307.3	NP_001258914.1|NP_112597	Q9BZE2	PUS3_HUMAN	pseudouridylate synthase 3	176						nucleus	RNA binding			NS(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)	10	all_hematologic(175;0.177)	Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.131)|all_lung(97;0.139)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.043)		GGGGCCCAGGCCAATATACGG	0.478000													44	37					2.26627e-22	2.82389e-22	1	1	0
TMBIM6	7009	broad.mit.edu	37	12	50152022	50152022	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:50152022G>A	ENST00000423828.1	+	5	801	c.473G>A	c.(472-474)gGc>gAc	p.G158D	TMBIM6_ENST00000552699.1_Missense_Mutation_p.G158D|TMBIM6_ENST00000547798.1_Missense_Mutation_p.G63D|TMBIM6_ENST00000549385.1_Missense_Mutation_p.G100D|TMBIM6_ENST00000267115.5_Missense_Mutation_p.G100D|TMBIM6_ENST00000395006.4_Missense_Mutation_p.G100D	NM_001098576.1	NP_001092046.1	P55061	BI1_HUMAN	transmembrane BAX inhibitor motif containing 6	100					apoptosis|negative regulation of apoptosis	endoplasmic reticulum|insoluble fraction|integral to plasma membrane|nucleus				lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	6						GTTGGCCTGGGCCCTGCCCTG	0.408000													66	94					0	0	1	0	0
TMEM143	55260	broad.mit.edu	37	19	48845927	48845927	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:48845927C>G	ENST00000293261.3	-	6	1151	c.835G>C	c.(835-837)Gcc>Ccc	p.A279P	TMEM143_ENST00000435956.3_Missense_Mutation_p.A244P|TMEM143_ENST00000541566.1_Missense_Mutation_p.A169P|TMEM143_ENST00000377431.2_Missense_Mutation_p.A179P|TMEM143_ENST00000436660.2_Missense_Mutation_p.A214P	NM_018273.2	NP_060743.2	Q96AN5	TM143_HUMAN	transmembrane protein 143	279						integral to membrane|mitochondrion		p.A279T(2)		endometrium(2)|kidney(1)|large_intestine(2)|lung(9)	14		all_epithelial(76;9.64e-05)|all_lung(116;0.000147)|Lung NSC(112;0.000251)|Prostate(7;0.0187)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000149)|all cancers(93;0.000198)|Epithelial(262;0.0151)|GBM - Glioblastoma multiforme(486;0.0157)		TTGAGCAGGGCGCGCTGCAGG	0.642000													35	24					0	0	1	0	0
RABEP2	79874	broad.mit.edu	37	16	28925724	28925724	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:28925724C>A	ENST00000358201.4	-	5	1315	c.727G>T	c.(727-729)Gtc>Ttc	p.V243F	RABEP2_ENST00000544477.1_Missense_Mutation_p.V172F|RABEP2_ENST00000357573.6_Missense_Mutation_p.V243F	NM_024816.2	NP_079092.2	Q9H5N1	RABE2_HUMAN	rabaptin, RAB GTPase binding effector protein 2	243					endocytosis|protein transport	early endosome	growth factor activity|GTPase activator activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|skin(1)	16						CTGCTGCCGACCCCACCGCCA	0.672000													37	32					3.76114e-14	4.29844e-14	1	1	0
ZNF839	55778	broad.mit.edu	37	14	102792535	102792535	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:102792535G>C	ENST00000262236.5	+	2	509	c.154G>C	c.(154-156)Gac>Cac	p.D52H	ZNF839_ENST00000559185.1_Missense_Mutation_p.D52H|ZNF839_ENST00000442396.2_Missense_Mutation_p.D168H|ZNF839_ENST00000558850.1_Missense_Mutation_p.D52H	NM_018335.4	NP_060805.3	A8K0R7	ZN839_HUMAN	zinc finger protein 839	52						intracellular	zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(5)|large_intestine(2)|lung(5)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	19						CTTCCTAAGTGACTTATGCCA	0.607000													38	17					0	0	1	0	0
CPNE8	144402	broad.mit.edu	37	12	39071345	39071345	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:39071345G>A	ENST00000331366.5	-	17	1379	c.1283C>T	c.(1282-1284)tCt>tTt	p.S428F	CPNE8_ENST00000546603.1_5'UTR|CPNE8_ENST00000360449.3_Missense_Mutation_p.S416F|CPNE8_ENST00000538596.2_Missense_Mutation_p.S97F	NM_153634.2	NP_705898.1	Q86YQ8	CPNE8_HUMAN	copine VIII	428	VWFA.									NS(1)|breast(1)|endometrium(1)|large_intestine(6)|lung(6)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)	21	Esophageal squamous(101;0.187)	Lung NSC(34;0.137)|Melanoma(24;0.152)|all_lung(34;0.157)				ATCCTTTACAGAAGAAGCATA	0.363000													15	29					0	0	1	0	0
NLRC3	197358	broad.mit.edu	37	16	3613643	3613643	+	RNA	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:3613643C>A	ENST00000301749.7	-	0	1700				NLRC3_ENST00000359128.5_RNA|NLRC3_ENST00000324659.8_RNA|NLRC3_ENST00000448023.2_RNA|NLRC3_ENST00000419350.2_RNA|NLRC3_ENST00000603507.1_RNA	NM_178844.2	NP_849172.2	Q7RTR2	NLRC3_HUMAN	NLR family, CARD domain containing 3						I-kappaB kinase/NF-kappaB cascade|negative regulation of NF-kappaB transcription factor activity|T cell activation	cytoplasm	ATP binding			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(1)|liver(1)|lung(16)|ovary(2)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						GCACGGGGCGCCCTGCAGCAG	0.587000													19	19					1.01871e-10	1.11573e-10	1	1	0
MUC16	94025	broad.mit.edu	37	19	9090068	9090068	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:9090068C>G	ENST00000397910.4	-	1	1950	c.1747G>C	c.(1747-1749)Gaa>Caa	p.E583Q		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	583	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GATGTTTCTTCAAGCCAAATC	0.532000													104	28					0	0	1	0	0
PMEL	6490	broad.mit.edu	37	12	56349451	56349451	+	Missense_Mutation	SNP	A	A	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:56349451A>C	ENST00000548747.1	-	9	2221	c.1559T>G	c.(1558-1560)cTg>cGg	p.L520R	PMEL_ENST00000552882.1_Missense_Mutation_p.L520R|PMEL_ENST00000550447.1_Missense_Mutation_p.L149R|PMEL_ENST00000360714.4_Missense_Mutation_p.L520R|PMEL_ENST00000449260.2_Missense_Mutation_p.L520R|PMEL_ENST00000550464.1_Missense_Mutation_p.L434R|PMEL_ENST00000536427.1_Missense_Mutation_p.L478R|PMEL_ENST00000539511.1_Missense_Mutation_p.L434R|PMEL_ENST00000548493.1_Missense_Mutation_p.L520R			P40967	PMEL_HUMAN	premelanosome protein	520					melanin biosynthetic process|melanosome organization	endoplasmic reticulum membrane|extracellular region|Golgi apparatus|integral to membrane|melanosome|multivesicular body membrane|plasma membrane	protein binding			NS(1)|breast(2)|endometrium(2)|large_intestine(4)|lung(4)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						TTCCTTGGGCAGCCTGGAAGA	0.577000													30	42					0	0	1	0	0
SVIL	6840	broad.mit.edu	37	10	29760165	29760165	+	Missense_Mutation	SNP	A	A	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:29760165A>T	ENST00000375398.2	-	33	5986	c.5537T>A	c.(5536-5538)gTt>gAt	p.V1846D	PTCHD3P1_ENST00000423223.1_RNA|SVIL_ENST00000375400.3_Missense_Mutation_p.V1420D|SVIL_ENST00000355867.4_Missense_Mutation_p.V1846D|PTCHD3P1_ENST00000446807.1_RNA|PTCHD3P1_ENST00000413405.1_RNA|PTCHD3P1_ENST00000414457.1_RNA|SVIL_ENST00000535393.1_Missense_Mutation_p.V760D			O95425	SVIL_HUMAN	supervillin	1846					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(24)|lung(35)|ovary(8)|prostate(2)|skin(4)|stomach(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	112		Breast(68;0.103)				TCCCTGGAGAACCTGGACCTT	0.498000													12	10					0	0	1	0	0
DIAPH3	81624	broad.mit.edu	37	13	60686272	60686272	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr13:60686272G>A	ENST00000400324.4	-	3	482	c.262C>T	c.(262-264)Cct>Tct	p.P88S	DIAPH3_ENST00000400320.1_Missense_Mutation_p.P77S|DIAPH3_ENST00000400319.1_Intron|DIAPH3_ENST00000267215.4_Missense_Mutation_p.P88S|DIAPH3_ENST00000377908.2_Missense_Mutation_p.P77S|DIAPH3_ENST00000400330.1_Missense_Mutation_p.P88S	NM_001042517.1|NM_001258366.1	NP_001035982.1|NP_001245295.1	Q9NSV4	DIAP3_HUMAN	diaphanous-related formin 3	88					actin cytoskeleton organization		actin binding|Rho GTPase binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|liver(1)|lung(20)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	46		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)		GGAAGTGGAGGTCTCTCTTTC	0.438000													97	129					0	0	1	0	0
IGHG3	3502	broad.mit.edu	37	14	106235715	106235715	+	RNA	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:106235715G>T	ENST00000390551.2	-	0	991																											AGAAGGAGCCGTCGGAGTCCA	0.597000													104	525					1.28261e-47	1.80153e-47	1	1	0
SLITRK3	22865	broad.mit.edu	37	3	164907895	164907895	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:164907895G>T	ENST00000475390.1	-	2	1167	c.724C>A	c.(724-726)Caa>Aaa	p.Q242K	SLITRK3_ENST00000241274.3_Missense_Mutation_p.Q242K			O94933	SLIK3_HUMAN	SLIT and NTRK-like family, member 3	242	LRRCT 1.					integral to membrane				NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(66)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(5)	119						CTCTTCAGTTGTACAATTTCA	0.463000										HNSCC(40;0.11)			47	93					1.23713e-20	1.51754e-20	1	1	0
CDKL5	6792	broad.mit.edu	37	X	18622521	18622521	+	Missense_Mutation	SNP	A	A	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chrX:18622521A>G	ENST00000379989.3	+	13	1762	c.1477A>G	c.(1477-1479)Agt>Ggt	p.S493G	CDKL5_ENST00000379996.3_Missense_Mutation_p.S493G|CDKL5_ENST00000463994.1_3'UTR	NM_001037343.1	NP_001032420.1	O76039	CDKL5_HUMAN	cyclin-dependent kinase-like 5	493					neuron migration|positive regulation of axon extension|positive regulation of dendrite morphogenesis|positive regulation of Rac GTPase activity|protein autophosphorylation	dendrite cytoplasm|dendritic growth cone|nucleus	ATP binding|cyclin-dependent protein kinase activity|Rac GTPase binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(12)|ovary(4)|skin(5)|stomach(1)	44	Hepatocellular(33;0.183)					TGGGGCACTGAGTGACTCCAA	0.517000													60	11					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158590242	158590242	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:158590242G>A	ENST00000368147.4	-	44	6315	c.6135C>T	c.(6133-6135)ttC>ttT	p.F2045F		NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)						actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					CAAATTCCACGAACAGGTCCT	0.423000													19	50					0	0	1	0	0
SF3B3	23450	broad.mit.edu	37	16	70605036	70605036	+	Silent	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:70605036G>T	ENST00000302516.5	+	25	3658	c.3447G>T	c.(3445-3447)cgG>cgT	p.R1149R		NM_012426.4	NP_036558.3	Q15393	SF3B3_HUMAN	splicing factor 3b, subunit 3, 130kDa	1149					protein complex assembly	catalytic step 2 spliceosome|nucleoplasm|small nuclear ribonucleoprotein complex|U12-type spliceosomal complex	nucleic acid binding|protein binding			breast(2)|endometrium(8)|kidney(2)|large_intestine(8)|liver(3)|lung(21)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	53		Ovarian(137;0.0694)				TGCACCTGCGGTCTGAACATC	0.498000													109	113					8.74965e-44	1.21352e-43	1	1	0
SLC40A1	30061	broad.mit.edu	37	2	190428407	190428407	+	Silent	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:190428407C>A	ENST00000261024.2	-	7	1731	c.1305G>T	c.(1303-1305)ggG>ggT	p.G435G		NM_014585.5	NP_055400.1	Q9NP59	S40A1_HUMAN	solute carrier family 40 (iron-regulated transporter), member 1	435					anatomical structure morphogenesis|cellular iron ion homeostasis	cytoplasm|integral to plasma membrane	iron ion transmembrane transporter activity|protein binding			endometrium(3)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(117;0.000917)|Epithelial(96;0.014)|all cancers(119;0.0491)			CAGAATTAGACCCATTAGACA	0.408000													41	49					1.67305e-13	1.90025e-13	1	1	0
BCR	613	broad.mit.edu	37	22	23626223	23626223	+	Silent	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr22:23626223G>C	ENST00000305877.8	+	9	2926	c.2175G>C	c.(2173-2175)ctG>ctC	p.L725L	BCR_ENST00000359540.3_Silent_p.L725L	NM_004327.3	NP_004318.3	P11274	BCR_HUMAN	breakpoint cluster region	725	PH.				regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	ATP binding|GTPase activator activity|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity		BCR/JAK2(6)	central_nervous_system(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	35						CCCGCAAGCTGCGCCACGTCT	0.657000			T	"""ABL1,  FGFR1, JAK2 """	"""CML, ALL, AML"""								4	10					0	0	1	0	0
ATM	472	broad.mit.edu	37	11	108206598	108206598	+	Silent	SNP	T	T	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:108206598T>A	ENST00000278616.4	+	56	8563	c.8178T>A	c.(8176-8178)gcT>gcA	p.A2726A	ATM_ENST00000452508.2_Silent_p.A2726A|C11orf65_ENST00000525729.1_Intron	NM_000051.3	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated	2726	PI3K/PI4K.		A -> V (in AT).		cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			NS(4)|breast(23)|central_nervous_system(11)|endometrium(10)|haematopoietic_and_lymphoid_tissue(227)|kidney(19)|large_intestine(53)|liver(5)|lung(62)|ovary(6)|pancreas(4)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	448		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		GACAAGATGCTGTCATGCAAC	0.348000			"""D, Mis, N, F, S"""		T-PLL	"""leukemia, lymphoma, medulloblastoma, glioma"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Ataxia Telangiectasia	TSP Lung(14;0.12)			20	21					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9016999	9016999	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:9016999G>A	ENST00000397910.4	-	27	38199	c.37996C>T	c.(37996-37998)Cct>Tct	p.P12666S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	12668					cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTGGGCACAGGGATCCAATGG	0.537000													25	141					0	0	1	0	0
ZNF225	7768	broad.mit.edu	37	19	44636769	44636769	+	Nonsense_Mutation	SNP	A	A	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:44636769A>T	ENST00000262894.6	+	5	2282	c.2002A>T	c.(2002-2004)Aaa>Taa	p.K668*	ZNF225_ENST00000590612.1_Nonsense_Mutation_p.K668*|ZNF225_ENST00000592780.1_3'UTR	NM_013362.2	NP_037494.2	Q9UK10	ZN225_HUMAN	zinc finger protein 225	668					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|skin(1)|stomach(1)	16		Prostate(69;0.0352)|all_neural(266;0.202)				TTCATGCCTTAAAGACCAACA	0.443000													23	9					0	0	1	0	0
NPNT	255743	broad.mit.edu	37	4	106858277	106858277	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:106858277C>T	ENST00000379987.2	+	4	593	c.377C>T	c.(376-378)tCc>tTc	p.S126F	NPNT_ENST00000514622.1_Missense_Mutation_p.S126F|NPNT_ENST00000305572.8_Missense_Mutation_p.S126F|NPNT_ENST00000427316.2_Missense_Mutation_p.S156F|NPNT_ENST00000506666.1_Missense_Mutation_p.S156F|NPNT_ENST00000453617.2_Missense_Mutation_p.S143F|NPNT_ENST00000513430.1_3'UTR	NM_001033047.2	NP_001028219.1	Q6UXI9	NPNT_HUMAN	nephronectin	126	EGF-like 2; calcium-binding (Potential).				cell differentiation	membrane	calcium ion binding			kidney(5)|large_intestine(2)|lung(10)|prostate(2)|skin(1)|urinary_tract(1)	21		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;5.41e-07)		CCGGATGGTTCCTGCTCAAGT	0.488000													35	95					0	0	1	0	0
ACTN2	88	broad.mit.edu	37	1	236925893	236925893	+	Missense_Mutation	SNP	G	G	A	rs148972050		TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:236925893G>A	ENST00000366578.4	+	21	2825	c.2659G>A	c.(2659-2661)Gca>Aca	p.A887T	ACTN2_ENST00000542672.1_Missense_Mutation_p.A887T|ACTN2_ENST00000546208.1_Missense_Mutation_p.A381T	NM_001103.2|NM_001278343.1	NP_001094.1|NP_001265272.1	P35609	ACTN2_HUMAN	actinin, alpha 2	887					focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			endometrium(4)|kidney(2)|large_intestine(15)|lung(55)|ovary(4)|prostate(3)|skin(3)	86	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			GTTCTCTTCCGCACTCTACGG	0.552000													8	92					0	0	1	0	0
PARM1	25849	broad.mit.edu	37	4	75937717	75937717	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:75937717G>T	ENST00000307428.7	+	2	338	c.126G>T	c.(124-126)tgG>tgT	p.W42C	RP11-44F21.2_ENST00000513770.1_RNA|PARM1_ENST00000513238.1_Intron	NM_015393.3	NP_056208.2	Q6UWI2	PARM1_HUMAN	prostate androgen-regulated mucin-like protein 1	42					positive regulation of telomerase activity	early endosome|endosome membrane|Golgi membrane|integral to membrane|late endosome|plasma membrane				cervix(1)|endometrium(2)|lung(4)|ovary(1)	8						CCACCATCTGGACTAGCTCTC	0.522000													32	56					2.80507e-11	3.11549e-11	1	1	0
TUBB2A	7280	broad.mit.edu	37	6	3154784	3154784	+	Silent	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:3154784C>G	ENST00000333628.3	-	4	713	c.651G>C	c.(649-651)ctG>ctC	p.L217L		NM_001069.2	NP_001060.1	Q13885	TBB2A_HUMAN	tubulin, beta 2A class IIa	217					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			endometrium(2)|large_intestine(4)|lung(2)|skin(1)	9	Ovarian(93;0.0386)	all_hematologic(90;0.0895)				TGGGGGTGGTCAGCTTCAGGG	0.612000													49	71					0	0	1	0	0
VIPR2	7434	broad.mit.edu	37	7	158824638	158824638	+	Silent	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:158824638C>T	ENST00000262178.2	-	11	1277	c.1092G>A	c.(1090-1092)ggG>ggA	p.G364G	VIPR2_ENST00000377633.3_Silent_p.G348G|VIPR2_ENST00000402066.1_Silent_p.G505G	NM_003382.4	NP_003373.2	P41587	VIPR2_HUMAN	vasoactive intestinal peptide receptor 2	364					cell-cell signaling	integral to plasma membrane				central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|pancreas(1)|skin(1)|stomach(1)	22	Ovarian(565;0.152)	all_cancers(7;1.13e-11)|all_epithelial(9;0.000545)|all_hematologic(28;0.00603)	OV - Ovarian serous cystadenocarcinoma(82;0.00231)	UCEC - Uterine corpus endometrioid carcinoma (81;0.2)|STAD - Stomach adenocarcinoma(7;0.18)		CCTGGAACGACCCGAGGCACA	0.607000													64	67					0	0	1	0	0
KIF26A	26153	broad.mit.edu	37	14	104642734	104642734	+	Silent	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:104642734C>G	ENST00000315264.7	+	11	3570	c.3192C>G	c.(3190-3192)gcC>gcG	p.A1064A	KIF26A_ENST00000423312.2_Silent_p.A1203A			Q9ULI4	KI26A_HUMAN	kinesin family member 26A	1203					blood coagulation|enteric nervous system development|microtubule-based movement|negative regulation of signal transduction|regulation of cell growth by extracellular stimulus	cytosol|microtubule	ATP binding|microtubule binding|microtubule motor activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	21		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0767)	Epithelial(46;0.152)	Epithelial(152;0.161)		CATCCGCAGCCCAGACCATCC	0.736000													16	20					0	0	1	0	0
ARHGAP19-SLIT1	100533184	broad.mit.edu	37	10	98807755	98807755	+	Splice_Site	SNP	T	T	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:98807755T>C	ENST00000453547.2	-	25	2742		c.e25-2		SLIT1_ENST00000266058.4_Splice_Site|SLIT1_ENST00000371070.4_Splice_Site																							GCTCTTTGGCTGGGAAGAGAA	0.597000													42	119					0	0	1	0	0
ADAMTS13	11093	broad.mit.edu	37	9	136323081	136323081	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:136323081G>A	ENST00000371929.3	+	28	4386	c.3942G>A	c.(3940-3942)tcG>tcA	p.S1314S	ADAMTS13_ENST00000356589.2_Silent_p.S1227S|ADAMTS13_ENST00000371910.1_Silent_p.S110S|ADAMTS13_ENST00000355699.2_Silent_p.S1258S|ADAMTS13_ENST00000485925.1_Intron|ADAMTS13_ENST00000371916.1_3'UTR	NM_139025.3|NM_139027.3	NP_620594.1|NP_620596.2	Q76LX8	ATS13_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 13	1314	CUB 2.				cell-matrix adhesion|glycoprotein metabolic process|integrin-mediated signaling pathway|peptide catabolic process|platelet activation|protein processing|proteolysis	cell surface|proteinaceous extracellular matrix	calcium ion binding|integrin binding|metalloendopeptidase activity|zinc ion binding			central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(13)|ovary(2)|prostate(3)|skin(4)	36				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		TGAGCCCCTCGCTGAGTCCAG	0.607000													61	54					0	0	1	0	0
IGLV2-23	28813	broad.mit.edu	37	22	23040596	23040596	+	RNA	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr22:23040596C>T	ENST00000390306.2	+	0	208																											TCCCTCTTTCCAGGGTCCTGG	0.612000													90	24					0	0	1	0	0
LONP1	9361	broad.mit.edu	37	19	5693378	5693378	+	Silent	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:5693378G>T	ENST00000360614.3	-	17	2791	c.2634C>A	c.(2632-2634)gcC>gcA	p.A878A	LONP1_ENST00000593119.1_Silent_p.A814A|LONP1_ENST00000585374.1_Silent_p.A764A|LONP1_ENST00000590729.1_Silent_p.A748A|LONP1_ENST00000540670.2_Silent_p.A682A	NM_004793.2	NP_004784.2	P36776	LONM_HUMAN	lon peptidase 1, mitochondrial	878					cellular chaperone-mediated protein complex assembly|cellular response to oxidative stress|misfolded or incompletely synthesized protein catabolic process|mitochondrial DNA metabolic process|oxidation-dependent protein catabolic process|protein homooligomerization|response to hypoxia	mitochondrial nucleoid	ADP binding|ATP binding|ATP-dependent peptidase activity|DNA polymerase binding|G-quadruplex DNA binding|mitochondrial heavy strand promoter anti-sense binding|mitochondrial light strand promoter anti-sense binding|sequence-specific DNA binding|serine-type endopeptidase activity|single-stranded DNA binding|single-stranded RNA binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						CGCCAGTCATGGCCAGATTCT	0.647000													61	11					1.33661e-31	1.7908e-31	1	1	0
NDNF	79625	broad.mit.edu	37	4	121958321	121958321	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:121958321G>A	ENST00000379692.4	-	4	1331	c.805C>T	c.(805-807)Cag>Tag	p.Q269*	NDNF_ENST00000506900.1_5'UTR	NM_024574.3	NP_078850.3	Q8TB73	CD031_HUMAN	neuron-derived neurotrophic factor	269	Fibronectin type-III 1.									breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(10)|prostate(3)|skin(1)|urinary_tract(1)	29						GGCTTTGCCTGGAAACTGCGT	0.463000													24	41					0	0	1	0	0
SH3PXD2A	9644	broad.mit.edu	37	10	105495534	105495534	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:105495534C>A	ENST00000369774.4	-	4	538	c.262G>T	c.(262-264)Gac>Tac	p.D88Y	SH3PXD2A_ENST00000355946.2_Missense_Mutation_p.D88Y			Q5TCZ1	SPD2A_HUMAN	SH3 and PX domains 2A	88	PX.				cell communication|superoxide metabolic process	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(8)|lung(18)|ovary(1)|skin(1)|urinary_tract(1)	38		Colorectal(252;0.0815)|Breast(234;0.131)		Epithelial(162;4.09e-10)|all cancers(201;2.73e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0119)		ACAGCTACGTCCCGGATGTGG	0.572000													107	63					4.37601e-64	6.32345e-64	1	1	0
TULP2	7288	broad.mit.edu	37	19	49385331	49385331	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:49385331G>A	ENST00000221399.3	-	12	1549	c.1405C>T	c.(1405-1407)Cgg>Tgg	p.R469W		NM_003323.2	NP_003314.2	O00295	TULP2_HUMAN	tubby like protein 2	469					visual perception	cytoplasm|extracellular region				NS(1)|breast(2)|central_nervous_system(2)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|skin(2)	22		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000259)|all cancers(93;0.000435)|Epithelial(262;0.0221)|GBM - Glioblastoma multiforme(486;0.0234)		ACCGAAGCCCGAGTGACTCGA	0.547000													16	81					0	0	1	0	0
FAT2	2196	broad.mit.edu	37	5	150945387	150945387	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:150945387C>A	ENST00000261800.5	-	1	3118	c.3106G>T	c.(3106-3108)Gtg>Ttg	p.V1036L		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	1036	Cadherin 9.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CCCTGGTGCACGAAGGAGGCA	0.602000													9	44					2.17888e-05	2.23558e-05	1	1	0
TMEM143	55260	broad.mit.edu	37	19	48846055	48846055	+	Missense_Mutation	SNP	T	T	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:48846055T>G	ENST00000293261.3	-	6	1023	c.707A>C	c.(706-708)aAg>aCg	p.K236T	TMEM143_ENST00000435956.3_Missense_Mutation_p.K201T|TMEM143_ENST00000541566.1_Missense_Mutation_p.K126T|TMEM143_ENST00000377431.2_Missense_Mutation_p.K136T|TMEM143_ENST00000436660.2_Missense_Mutation_p.K171T	NM_018273.2	NP_060743.2	Q96AN5	TM143_HUMAN	transmembrane protein 143	236						integral to membrane|mitochondrion				endometrium(2)|kidney(1)|large_intestine(2)|lung(9)	14		all_epithelial(76;9.64e-05)|all_lung(116;0.000147)|Lung NSC(112;0.000251)|Prostate(7;0.0187)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000149)|all cancers(93;0.000198)|Epithelial(262;0.0151)|GBM - Glioblastoma multiforme(486;0.0157)		GACCACCCGCTTAAAGTATCT	0.627000													26	16					0	0	1	0	0
ATP7A	538	broad.mit.edu	37	X	77271359	77271359	+	Silent	SNP	A	A	G	rs61053012	byFrequency	TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chrX:77271359A>G	ENST00000341514.6	+	12	2762	c.2607A>G	c.(2605-2607)gtA>gtG	p.V869V	ATP7A_ENST00000350425.4_Intron|ATP7A_ENST00000343533.5_Silent_p.V791V	NM_000052.5	NP_000043.4	Q04656	ATP7A_HUMAN	ATPase, Cu++ transporting, alpha polypeptide	869					ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity			breast(4)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(26)|pancreas(1)|prostate(1)|urinary_tract(1)	53						ATTCTATGGTAGATGAGTCCC	0.378000													60	1					0	0	1	0	0
MSANTD4	84437	broad.mit.edu	37	11	105880543	105880543	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:105880543C>G	ENST00000301919.4	-	3	2172	c.757G>C	c.(757-759)Gag>Cag	p.E253Q		NM_032424.1	NP_115800.1	Q8NCY6	K1826_HUMAN	Myb/SANT-like DNA-binding domain containing 4 with coiled-coils	253						nucleus											CGCTCCTTCTCTAGCTGAAGC	0.463000													63	67					0	0	1	0	0
SEMA3D	223117	broad.mit.edu	37	7	84628764	84628764	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:84628764C>T	ENST00000284136.6	-	17	2369	c.2326G>A	c.(2326-2328)Gcc>Acc	p.A776T	SEMA3D_ENST00000484038.1_5'UTR	NM_152754.2	NP_689967.2	O95025	SEM3D_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D	776					cell differentiation|nervous system development	extracellular region|membrane	receptor activity			NS(1)|breast(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(19)|lung(29)|ovary(3)|pancreas(1)|prostate(4)|skin(2)	73						AACTACGTGGCTACAGCTCTA	0.393000													26	43					0	0	1	0	0
ADAMTS5	11096	broad.mit.edu	37	21	28296648	28296648	+	Silent	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr21:28296648G>T	ENST00000284987.5	-	8	2638	c.2517C>A	c.(2515-2517)ccC>ccA	p.P839P	AP001601.2_ENST00000426771.1_RNA	NM_007038.3	NP_008969.2	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 5	839	Spacer.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	72						ATGGTTTAGTGGGGTCTGTTG	0.453000													55	99					9.72345e-25	1.23671e-24	1	1	0
SLC34A1	6569	broad.mit.edu	37	5	176815166	176815166	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:176815166G>T	ENST00000324417.5	+	7	907	c.816G>T	c.(814-816)gaG>gaT	p.E272D	SLC34A1_ENST00000512593.1_Missense_Mutation_p.E272D	NM_003052.4	NP_003043.3	Q06495	NPT2A_HUMAN	solute carrier family 34 (type II sodium/phosphate contransporter), member 1	272					phosphate ion homeostasis|response to cadmium ion|response to lead ion|response to mercury ion|sodium ion transport	brush border membrane|integral to plasma membrane	protein binding|sodium-dependent phosphate transmembrane transporter activity|symporter activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	24	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TCATCACAGAGCCCTTCACGA	0.597000													41	13					7.63091e-17	9.01984e-17	1	1	0
HCK	3055	broad.mit.edu	37	20	30672279	30672279	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:30672279G>A	ENST00000534862.1	+	9	1071	c.708G>A	c.(706-708)gaG>gaA	p.E236E	HCK_ENST00000518730.1_Silent_p.E234E|HCK_ENST00000375862.2_Silent_p.E255E|HCK_ENST00000520553.1_Silent_p.E235E|HCK_ENST00000538448.1_Silent_p.E235E|HCK_ENST00000375852.2_Silent_p.E256E	NM_001172132.1	NP_001165603.1	P08631	HCK_HUMAN	hemopoietic cell kinase	256	SH2.				interspecies interaction between organisms|mesoderm development|regulation of defense response to virus by virus|viral reproduction	caveola|cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			NS(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(18)|ovary(2)|pancreas(1)|prostate(2)|skin(4)	36			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			ATGCCTGGGAGATCCCTCGGG	0.602000													30	84					0	0	1	0	0
EML5	161436	broad.mit.edu	37	14	89148328	89148328	+	Silent	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:89148328C>T	ENST00000554922.1	-	21	3278	c.3030G>A	c.(3028-3030)ctG>ctA	p.L1010L	EML5_ENST00000352093.5_Silent_p.L972L|EML5_ENST00000380664.5_Silent_p.L1010L	NM_183387.2	NP_899243.1	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like 5	1010						cytoplasm|microtubule				breast(1)|endometrium(3)|kidney(4)|large_intestine(17)|lung(14)|ovary(3)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						CACAGATGGGCAGATAAGGGT	0.408000													44	54					0	0	1	0	0
ADAM32	203102	broad.mit.edu	37	8	39103645	39103645	+	Missense_Mutation	SNP	C	C	T	rs142346085	by1000genomes	TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr8:39103645C>T	ENST00000379907.4	+	17	1989	c.1862C>T	c.(1861-1863)gCt>gTt	p.A621V	ADAM32_ENST00000519315.1_Missense_Mutation_p.A515V|ADAM32_ENST00000437682.2_Missense_Mutation_p.A522V	NM_145004.5	NP_659441	Q8TC27	ADA32_HUMAN	ADAM metallopeptidase domain 32	621					proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|skin(2)	31		all_cancers(7;3e-05)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00771)|Breast(189;0.0503)	LUSC - Lung squamous cell carcinoma(45;6.2e-07)|Colorectal(1;0.00699)|READ - Rectum adenocarcinoma(1;0.146)			ATAATTAAGGCTTCAGCACAT	0.368000													29	168					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11039328	11039328	+	RNA	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr21:11039328C>T	ENST00000470054.1	-	0	875									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TCCATTTTATCTTCAATTTGA	0.378000													21	301					0	0	1	0	0
C3	718	broad.mit.edu	37	19	6696452	6696452	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:6696452G>T	ENST00000245907.6	-	23	2980	c.2888C>A	c.(2887-2889)cCa>cAa	p.P963Q		NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	963					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		GTCTGCAGGTGGGATGTCCTC	0.572000													36	22					4.4194e-11	4.87902e-11	1	1	0
TEP1	7011	broad.mit.edu	37	14	20876347	20876347	+	Silent	SNP	T	T	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:20876347T>A	ENST00000262715.5	-	2	292	c.252A>T	c.(250-252)acA>acT	p.T84T	TEP1_ENST00000556935.1_Silent_p.T84T	NM_007110.4	NP_009041.2	Q99973	TEP1_HUMAN	telomerase-associated protein 1	84					telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			NS(4)|breast(1)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(48)|ovary(7)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	96	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		GGTCAGAAAGTGTGGCCAGGC	0.552000													75	69					0	0	1	0	0
PPP1R10	5514	broad.mit.edu	37	6	30571979	30571979	+	Silent	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:30571979C>A	ENST00000376511.2	-	14	1866	c.1314G>T	c.(1312-1314)ctG>ctT	p.L438L		NM_002714.3	NP_002705.2	Q96QC0	PP1RA_HUMAN	protein phosphatase 1, regulatory subunit 10	438	Essential for PPP1CA inhibition (By similarity).|Interaction with WDR82 (By similarity).				protein import into nucleus|transcription, DNA-dependent	PTW/PP1 phosphatase complex	DNA binding|protein phosphatase inhibitor activity|RNA binding|zinc ion binding			cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(9)|ovary(2)|prostate(3)|skin(1)	25						GTCGGTCTGACAGTATCTCTC	0.542000													68	72					9.04393e-38	1.24185e-37	1	1	0
MTNR1B	4544	broad.mit.edu	37	11	92715238	92715238	+	Silent	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:92715238C>G	ENST00000257068.2	+	2	855	c.849C>G	c.(847-849)ccC>ccG	p.P283P		NM_005959.3	NP_005950.1	P49286	MTR1B_HUMAN	melatonin receptor 1B	283					G-protein signaling, coupled to cyclic nucleotide second messenger|glucose homeostasis|regulation of insulin secretion|synaptic transmission	integral to plasma membrane	melatonin receptor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(19)|ovary(1)|prostate(2)|urinary_tract(1)	33		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)			Ramelteon(DB00980)	AAATGGCTCCCCAGATCCCTG	0.498000													116	172					0	0	1	0	0
APOA4	337	broad.mit.edu	37	11	116692251	116692251	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:116692251G>C	ENST00000357780.3	-	3	637	c.523C>G	c.(523-525)Ctg>Gtg	p.L175V		NM_000482.3	NP_000473.2			apolipoprotein A-IV											cervix(1)|endometrium(2)|lung(10)|prostate(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	20	all_hematologic(175;0.0487)	Breast(348;0.0126)|Medulloblastoma(222;0.0425)|all_hematologic(158;0.0564)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|Epithelial(105;1.62e-05)|all cancers(92;0.000165)|OV - Ovarian serous cystadenocarcinoma(223;0.148)		GAGGCCTGCAGGCTGTCGGCG	0.672000													119	122					0	0	1	0	0
GTF3C1	2975	broad.mit.edu	37	16	27475764	27475764	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:27475764C>T	ENST00000356183.4	-	34	5764	c.5749G>A	c.(5749-5751)Gaa>Aaa	p.E1917K	GTF3C1_ENST00000561623.1_Missense_Mutation_p.E1917K	NM_001520.3	NP_001511.2	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide 1, alpha 220kDa	1917						transcription factor TFIIIC complex	DNA binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|liver(3)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	80						GCGGTGTCTTCAAGAGCTGGG	0.652000													107	104					0	0	1	0	0
INF2	64423	broad.mit.edu	37	14	105174812	105174812	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:105174812C>A	ENST00000392634.4	+	9	1887	c.1775C>A	c.(1774-1776)gCc>gAc	p.A592D	INF2_ENST00000330634.7_Missense_Mutation_p.A592D	NM_022489.3	NP_071934.3	Q27J81	INF2_HUMAN	inverted formin, FH2 and WH2 domain containing	592	FH2.				actin cytoskeleton organization	endoplasmic reticulum|nucleus|perinuclear region of cytoplasm	actin binding|Rho GTPase binding			large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	8		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00188)|OV - Ovarian serous cystadenocarcinoma(23;0.0191)|Epithelial(46;0.047)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.176)		AGCCCCGACGCCGAGGCTGTG	0.682000											OREG0022959	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	61	62					1.34159e-35	1.82404e-35	1	1	0
PCDHA1	56147	broad.mit.edu	37	5	140167598	140167598	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:140167598G>A	ENST00000504120.2	+	1	1723	c.1723G>A	c.(1723-1725)Ggt>Agt	p.G575S	PCDHA1_ENST00000378133.3_Missense_Mutation_p.G575S|PCDHA1_ENST00000394633.3_Intron	NM_018900.2	NP_061723.1														breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(34)|prostate(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(3)	70			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGCACTATTGGTGCAGTCAG	0.672000													91	44					0	0	1	0	0
MEGF10	84466	broad.mit.edu	37	5	126754869	126754869	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:126754869C>T	ENST00000274473.6	+	12	1630	c.1363C>T	c.(1363-1365)Cgc>Tgc	p.R455C	MEGF10_ENST00000508365.1_Missense_Mutation_p.R455C|MEGF10_ENST00000503335.2_Missense_Mutation_p.R455C|MEGF10_ENST00000418761.2_Missense_Mutation_p.R455C	NM_032446.2	NP_115822.1	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10	455	EGF-like 8.|Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(28)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	68		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		CTGTTCCTCTCGCTGTGGCTG	0.458000													23	107					0	0	1	0	0
AHR	196	broad.mit.edu	37	7	17379440	17379440	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:17379440G>T	ENST00000242057.4	+	10	2634	c.1991G>T	c.(1990-1992)tGt>tTt	p.C664F		NM_001621.4	NP_001612.1	P35869	AHR_HUMAN	aryl hydrocarbon receptor	664					apoptosis|blood vessel development|cell cycle|regulation of B cell proliferation|response to stress|transcription from RNA polymerase II promoter|xenobiotic metabolic process	cytosolic aryl hydrocarbon receptor complex|transcription factor complex	Hsp90 protein binding|ligand-dependent nuclear receptor activity|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(11)|ovary(1)|pancreas(1)|urinary_tract(3)	33	Lung NSC(10;0.0392)|all_lung(11;0.0754)					CCTTTCAATTGTCCACAGCAA	0.408000													81	78					6.71967e-41	9.27314e-41	1	1	0
LCA5L	150082	broad.mit.edu	37	21	40795035	40795035	+	Missense_Mutation	SNP	A	A	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr21:40795035A>G	ENST00000358268.2	-	5	1232	c.704T>C	c.(703-705)tTa>tCa	p.L235S	LCA5L_ENST00000380671.2_Missense_Mutation_p.L235S|LCA5L_ENST00000485895.2_Missense_Mutation_p.L235S|LCA5L_ENST00000288350.3_Missense_Mutation_p.L235S			O95447	LCA5L_HUMAN	Leber congenital amaurosis 5-like	235										breast(1)|cervix(1)|endometrium(3)|large_intestine(8)|lung(4)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	24		Prostate(19;1.2e-06)				AGTCTTCAGTAACTGGCTGTC	0.353000													39	55					0	0	1	0	0
UNC5C	8633	broad.mit.edu	37	4	96222783	96222783	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:96222783C>T	ENST00000453304.1	-	3	812	c.464G>A	c.(463-465)aGc>aAc	p.S155N	UNC5C_ENST00000504962.1_Missense_Mutation_p.S155N|UNC5C_ENST00000506749.1_Missense_Mutation_p.S155N	NM_003728.3	NP_003719.3	O95185	UNC5C_HUMAN	unc-5 homolog C (C. elegans)	155	Ig-like.				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(14)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	55		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		CGCCTTCCGGCTCTTTGTGGT	0.498000													49	40					0	0	1	0	0
TRRAP	8295	broad.mit.edu	37	7	98487961	98487961	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:98487961G>A	ENST00000359863.4	+	4	363	c.154G>A	c.(154-156)Gtc>Atc	p.V52I	TRRAP_ENST00000355540.3_Missense_Mutation_p.V52I|TRRAP_ENST00000446306.3_Missense_Mutation_p.V52I	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	52					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			CAATTAGAATGTCACGTCATC	0.328000													22	24					0	0	1	0	0
ENTPD8	377841	broad.mit.edu	37	9	140330634	140330634	+	Missense_Mutation	SNP	T	T	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:140330634T>G	ENST00000371506.2	-	7	1064	c.881A>C	c.(880-882)cAc>cCc	p.H294P	ENTPD8_ENST00000472938.1_Missense_Mutation_p.H294P|ENTPD8_ENST00000344119.2_Missense_Mutation_p.H294P	NM_001033113.1	NP_001028285.1	Q5MY95	ENTP8_HUMAN	ectonucleoside triphosphate diphosphohydrolase 8	294						integral to membrane|plasma membrane	ATP binding			biliary_tract(1)|lung(4)|prostate(1)|skin(1)	7	all_cancers(76;0.0926)			OV - Ovarian serous cystadenocarcinoma(145;0.000224)|Epithelial(140;0.000898)		GGGCGTGGCGTGGACACAGGG	0.657000													35	49					0	0	1	0	0
ZNF143	7702	broad.mit.edu	37	11	9522678	9522678	+	Silent	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:9522678G>T	ENST00000396602.2	+	11	1127	c.1008G>T	c.(1006-1008)cgG>cgT	p.R336R	ZNF143_ENST00000396604.1_Silent_p.R335R|ZNF143_ENST00000396597.3_Silent_p.R305R|ZNF143_ENST00000530463.1_Silent_p.R335R|ZNF143_ENST00000299606.2_Silent_p.R308R	NM_001282656.1|NM_001282657.1|NM_003442.5	NP_001269585.1|NP_001269586.1|NP_003433.3	P52747	ZN143_HUMAN	zinc finger protein 143	336					regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding|zinc ion binding			endometrium(1)|large_intestine(5)|lung(4)|skin(2)|upper_aerodigestive_tract(1)	13				all cancers(16;4.12e-09)|Epithelial(150;2.29e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0212)		GCTGCGGTCGGTCCTTTACAA	0.423000													71	10					8.27458e-37	1.13339e-36	1	1	0
C19orf52	90580	broad.mit.edu	37	19	11040151	11040151	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:11040151G>T	ENST00000270502.6	+	2	646	c.556G>T	c.(556-558)Gac>Tac	p.D186Y		NM_138358.2	NP_612367.1	Q9BSF4	CS052_HUMAN	chromosome 19 open reading frame 52	186										prostate(1)	1						CGACATCAACGACGACGAATT	0.672000													100	40					3.45148e-53	4.92304e-53	1	1	0
DNM1P46	196968	broad.mit.edu	37	15	100340361	100340361	+	RNA	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr15:100340361G>A	ENST00000341853.1	-	0	565					NR_003260.1																						GCATCTCGTCGCGCCGCTGTG	0.612000													17	17					0	0	1	0	0
ABCC1	4363	broad.mit.edu	37	16	16130386	16130386	+	Silent	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:16130386C>T	ENST00000399408.2	+	7	910	c.735C>T	c.(733-735)aaC>aaT	p.N245N	ABCC1_ENST00000349029.5_Silent_p.N245N|ABCC1_ENST00000399410.3_Silent_p.N245N|ABCC1_ENST00000351154.5_Silent_p.N245N|ABCC1_ENST00000346370.5_Silent_p.N245N|ABCC1_ENST00000345148.5_Silent_p.N245N			P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	245					hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|endometrium(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(5)|prostate(1)|skin(3)	56					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	GGTCCTTAAACAAGGAGGACA	0.532000													66	74					0	0	1	0	0
GPR124	25960	broad.mit.edu	37	8	37698748	37698748	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr8:37698748G>T	ENST00000315215.7	+	16	2604	c.2241G>T	c.(2239-2241)agG>agT	p.R747S	GPR124_ENST00000412232.2_Missense_Mutation_p.R964S			Q96PE1	GP124_HUMAN	G protein-coupled receptor 124	964	GPS.				central nervous system development|endothelial cell migration|neuropeptide signaling pathway|regulation of angiogenesis|regulation of chemotaxis|sprouting angiogenesis	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(16)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	37			BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)			GCAACAGCAGGGCCTCCCTGG	0.637000													38	155					2.75727e-19	3.30873e-19	1	1	0
ZNF878	729747	broad.mit.edu	37	19	12167103	12167103	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:12167103G>C	ENST00000602107.1	-	1	24	c.25C>G	c.(25-27)Ctg>Gtg	p.L9V				C9JN71	ZN878_HUMAN	zinc finger protein 878	0	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			cervix(1)|endometrium(1)|kidney(1)|lung(4)|urinary_tract(1)	8						TACAACCCCAGATAGGACAGA	0.562000													4	4					0	0	1	0	0
PTPRC	5788	broad.mit.edu	37	1	198713182	198713182	+	Splice_Site	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:198713182G>T	ENST00000367376.2	+	26	2862		c.e26-1		PTPRC_ENST00000352140.3_Splice_Site|PTPRC_ENST00000442510.2_Splice_Site|PTPRC_ENST00000594404.1_Splice_Site|PTPRC_ENST00000348564.6_Splice_Site	NM_002838.4	NP_002829.3	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C						axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(7)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(22)|lung(41)|ovary(4)|pancreas(2)|prostate(1)|skin(13)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	111						TGAAATTGTAGGCCCAGTACA	0.328000													32	24					3.76114e-14	4.29844e-14	1	1	0
RDM1	201299	broad.mit.edu	37	17	34251642	34251642	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:34251642G>A	ENST00000394529.3	-	3	951	c.465C>T	c.(463-465)ggC>ggT	p.G155G	RDM1_ENST00000591402.1_Intron|RDM1_ENST00000430160.2_Silent_p.G155G|RDM1_ENST00000394528.3_Silent_p.G178G|RDM1_ENST00000293273.6_Silent_p.G178G|RDM1_ENST00000431884.2_Silent_p.G178G|RDM1_ENST00000425909.3_Intron|RDM1_ENST00000419453.2_Silent_p.G155G|RDM1_ENST00000394527.1_Intron	NM_001163130.1	NP_001156602.1	Q8NG50	RDM1_HUMAN	RAD52 motif 1	178					DNA recombination|DNA repair	Cajal body|cytoplasm|nucleolus|PML body	DNA binding|nucleotide binding|RNA binding			breast(1)|kidney(3)|large_intestine(2)|ovary(1)|skin(1)|stomach(1)	9		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		CCTCCACCAAGCCAATGCCAG	0.483000								Other identified genes with known or suspected DNA repair function					113	10					0	0	1	0	0
SCNN1B	6338	broad.mit.edu	37	16	23388689	23388689	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:23388689G>A	ENST00000343070.2	+	10	1562	c.1386G>A	c.(1384-1386)tgG>tgA	p.W462*	SCNN1B_ENST00000307331.5_Nonsense_Mutation_p.W507*|SCNN1B_ENST00000568923.1_Nonsense_Mutation_p.W435*|SCNN1B_ENST00000568085.1_Nonsense_Mutation_p.W426*	NM_000336.2	NP_000327.2	P51168	SCNNB_HUMAN	sodium channel, non-voltage-gated 1, beta subunit	462					excretion|sensory perception of taste	apical plasma membrane	ligand-gated sodium channel activity|WW domain binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|liver(2)|lung(8)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	32				GBM - Glioblastoma multiforme(48;0.0465)	Amiloride(DB00594)|Triamterene(DB00384)	TGGCTGACTGGCCTTCTGAGG	0.587000													34	55					0	0	1	0	0
SNX27	81609	broad.mit.edu	37	1	151611551	151611551	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:151611551G>A	ENST00000368843.3	+	2	619	c.499G>A	c.(499-501)Gtc>Atc	p.V167I	SNX27_ENST00000368838.1_Missense_Mutation_p.V74I|SNX27_ENST00000458013.2_Missense_Mutation_p.V167I	NM_030918.5	NP_112180.4	Q96L92	SNX27_HUMAN	sorting nexin family member 27	167	PX.				cell communication|protein transport|signal transduction	cytosol|early endosome	phosphatidylinositol binding|protein binding			central_nervous_system(1)|large_intestine(2)|ovary(2)	5	Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			GCCCATATCGGTCCCCAGATA	0.463000													49	73					0	0	1	0	0
USP7	7874	broad.mit.edu	37	16	9014215	9014215	+	Splice_Site	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:9014215C>T	ENST00000344836.4	-	5	810		c.e5+1		USP7_ENST00000535863.1_Splice_Site|USP7_ENST00000381886.4_Splice_Site	NM_003470.2	NP_003461.2	Q93009	UBP7_HUMAN	ubiquitin specific peptidase 7 (herpes virus-associated)						interspecies interaction between organisms|multicellular organismal development|protein deubiquitination|regulation of sequence-specific DNA binding transcription factor activity|ubiquitin-dependent protein catabolic process	cytoplasm|PML body	cysteine-type endopeptidase activity|p53 binding|protein C-terminus binding|transcription factor binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(13)|lung(20)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	48						GAAAAACTTACGCAACTCCAT	0.378000													37	51					0	0	1	0	0
PLXNB3	5365	broad.mit.edu	37	X	153037013	153037013	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chrX:153037013G>A	ENST00000538966.1	+	15	2760	c.2489G>A	c.(2488-2490)tGc>tAc	p.C830Y	PLXNB3_ENST00000361971.5_Missense_Mutation_p.C807Y|PLXNB3_ENST00000538282.1_Missense_Mutation_p.C417Y|PLXNB3_ENST00000538776.1_Missense_Mutation_p.C460Y|PLXNB3_ENST00000538543.1_Intron	NM_001163257.1	NP_001156729.1	Q9ULL4	PLXB3_HUMAN	plexin B3	807					axon guidance	integral to membrane|intracellular|plasma membrane	protein binding|receptor activity			central_nervous_system(1)|endometrium(7)|large_intestine(2)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	32	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					AGCCTGGGCTGCCTGTGGTGT	0.672000													29	0					0	0	1	0	0
RGS9	8787	broad.mit.edu	37	17	63221386	63221386	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:63221386G>A	ENST00000449996.3	+	18	1737	c.1665G>A	c.(1663-1665)gaG>gaA	p.E555E	RGS9_ENST00000262406.9_Silent_p.E558E|RGS9_ENST00000443584.3_Silent_p.E555E	NM_001081955.2	NP_001075424.1	O75916	RGS9_HUMAN	regulator of G-protein signaling 9	558				E -> D (in Ref. 7; AAC25430).	intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(8)|liver(2)|lung(12)|ovary(2)|prostate(3)|skin(3)	41						AGAGCAGCGAGGCCTCCCTCG	0.672000													104	165					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124048787	124048787	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:124048787C>G	ENST00000360013.3	+	8	1485	c.1358C>G	c.(1357-1359)gCa>gGa	p.A453G	KALRN_ENST00000240874.3_Missense_Mutation_p.A453G|KALRN_ENST00000460856.1_Missense_Mutation_p.A453G	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	453					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						CTAGAGCTGGCAATCCACCAC	0.562000													71	71					0	0	1	0	0
FAM43B	163933	broad.mit.edu	37	1	20880268	20880270	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:20880268_20880270delGAG	ENST00000332947.4	+	1	1337_1339	c.802_804delGAG	c.(802-804)gagdel	p.E272del		NM_207334.2	NP_997217.1	Q6ZT52	FA43B_HUMAN	family with sequence similarity 43, member B	272										large_intestine(1)|lung(2)	3		Colorectal(325;0.000147)|Renal(390;0.000469)|Lung NSC(340;0.00412)|all_lung(284;0.00419)|Breast(348;0.00979)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|COAD - Colon adenocarcinoma(152;1.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000132)|Kidney(64;0.00016)|GBM - Glioblastoma multiforme(114;0.000399)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.195)		ggaggaggacgaggaggaggagg	0.744													2	4	---	---	---	---					
HFE2	148738	broad.mit.edu	37	1	145415369	145415371	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:145415369_145415371delGAG	ENST00000336751.5	+	3	426_428	c.188_190delGAG	c.(187-192)cgagga>cga	p.G69del	HFE2_ENST00000357836.5_5'UTR|HFE2_ENST00000475797.1_Intron|HFE2_ENST00000497365.1_Intron	NM_213653.3	NP_998818.1	Q6ZVN8	RGMC_HUMAN	hemochromatosis type 2 (juvenile)	69	Poly-Gly.			G -> GG (in Ref. 3; ABC40718).	axon guidance	anchored to membrane				central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)	14	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GGAGCACTTCGAGGAGGAGGAGG	0.626													7	161	---	---	---	---					
PPARG	5468	broad.mit.edu	37	3	12422901	12422902	+	Frame_Shift_Ins	INS	-	-	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:12422901_12422902insC	ENST00000397026.2	+	5	708_709	c.325_326insC	c.(325-327)tccfs	p.S109fs	PPARG_ENST00000397000.1_Frame_Shift_Ins_p.S103fs|PPARG_ENST00000309576.6_Frame_Shift_Ins_p.S103fs|PPARG_ENST00000397012.2_Frame_Shift_Ins_p.S103fs|PPARG_ENST00000397015.2_Frame_Shift_Ins_p.S103fs|PPARG_ENST00000287820.6_Frame_Shift_Ins_p.S131fs|PPARG_ENST00000397010.2_Frame_Shift_Ins_p.S103fs|PPARG_ENST00000539812.1_Frame_Shift_Ins_p.S101fs			P37231	PPARG_HUMAN	peroxisome proliferator-activated receptor gamma	131					activation of caspase activity|cell fate commitment|cell maturation|cellular response to insulin stimulus|epithelial cell differentiation|glucose homeostasis|induction of apoptosis|innate immune response|lipid homeostasis|lipoprotein transport|long-chain fatty acid transport|low-density lipoprotein particle receptor biosynthetic process|monocyte differentiation|negative regulation of cholesterol storage|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of macrophage derived foam cell differentiation|negative regulation of receptor biosynthetic process|negative regulation of sequestering of triglyceride|negative regulation of transcription from RNA polymerase II promoter|placenta development|positive regulation of fat cell differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to lipid|response to low-density lipoprotein particle stimulus|white fat cell differentiation	cytosol|nucleoplasm	activating transcription factor binding|arachidonic acid binding|drug binding|enzyme binding|prostaglandin receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding		PAX8/PPARG(117)	breast(2)|endometrium(4)|kidney(3)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)|skin(1)|stomach(1)	20					Atorvastatin(DB01076)|Icosapent(DB00159)|Pioglitazone(DB01132)|Rosiglitazone(DB00412)|Troglitazone(DB00197)	TGAAGAGCCTTCCAACTCCCTC	0.426			T	PAX8	follicular thyroid		"""Insulin resistance ; lipodystrophy, familial partial L;diabetes mellitus, insulin-resistantI, with acanthosis nigricans and hypertension"""						15	72	---	---	---	---					
NOP14	8602	broad.mit.edu	37	4	2941321	2941327	+	Frame_Shift_Del	DEL	GGCAGAG	GGCAGAG	-	rs138901812	byFrequency	TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:2941321_2941327delGGCAGAG	ENST00000416614.2	-	16	2310_2316	c.2245_2251delCTCTGCC	c.(2245-2253)ctctgccggfs	p.LCR749fs	NOP14-AS1_ENST00000512712.2_RNA|NOP14_ENST00000502735.1_Frame_Shift_Del_p.LCR749fs|NOP14-AS1_ENST00000515194.1_RNA|NOP14-AS1_ENST00000512802.1_RNA|NOP14_ENST00000398071.4_Frame_Shift_Del_p.LCR749fs|NOP14-AS1_ENST00000507702.1_RNA|NOP14-AS1_ENST00000505731.1_RNA|NOP14-AS1_ENST00000503709.1_RNA|NOP14_ENST00000507120.1_5'UTR|NOP14-AS1_ENST00000507999.1_RNA|NOP14_ENST00000314262.6_Frame_Shift_Del_p.LCR749fs			P78316	NOP14_HUMAN	NOP14 nucleolar protein	749					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	mitochondrion|Noc4p-Nop14p complex|small-subunit processome	snoRNA binding			NS(1)|endometrium(2)|kidney(3)|large_intestine(9)|lung(12)|pancreas(1)|skin(1)|urinary_tract(1)	30						GTCAGCGGCCGGCAGAGCTGCTTCTGG	0.589													17	49	---	---	---	---					
CTD-2296D1.4	0	broad.mit.edu	37	5	7372616	7372616	+	RNA	DEL	A	A	-			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:7372616delA	ENST00000513219.1	-	0	202																											caccaccaccacctccaccat	0.597													2	4	---	---	---	---					
HIST1H2BB	3018	broad.mit.edu	37	6	26043564	26043564	+	Frame_Shift_Del	DEL	C	C	-			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:26043564delC	ENST00000357905.2	-	1	321	c.322delG	c.(322-324)gctfs	p.A108fs		NM_021062.2	NP_066406.1	P33778	H2B1B_HUMAN	histone cluster 1, H2bb	108					nucleosome assembly	nucleosome|nucleus	DNA binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)	7						GCATGCTTAGCCAGCTCCCCA	0.552													49	53	---	---	---	---					
RGL2	5863	broad.mit.edu	37	6	33262770	33262771	+	Frame_Shift_Ins	INS	-	-	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:33262770_33262771insA	ENST00000497454.1	-	10	1756_1757	c.1261_1262insT	c.(1261-1263)tctfs	p.S421fs	PFDN6_ENST00000463584.1_Intron|RGL2_ENST00000444031.2_Frame_Shift_Ins_p.S339fs|RGL2_ENST00000437840.2_5'UTR	NM_001243738.1|NM_004761.4	NP_001230667.1|NP_004752.1	O15211	RGL2_HUMAN	ral guanine nucleotide dissociation stimulator-like 2	421	Ras-GEF.				Ras protein signal transduction|regulation of small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity			breast(2)|cervix(2)|endometrium(7)|kidney(2)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	34						CCGGGAGCCAGACCTCGGGGCC	0.589													8	5	---	---	---	---					
ADCY1	107	broad.mit.edu	37	7	45725689	45725689	+	Frame_Shift_Del	DEL	C	C	-			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:45725689delC	ENST00000297323.7	+	13	2224	c.2202delC	c.(2200-2202)tgcfs	p.C734fs		NM_021116.2	NP_066939.1	Q08828	ADCY1_HUMAN	adenylate cyclase 1 (brain)	734					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(14)|lung(33)|ovary(4)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	71					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)|Adenosine(DB00640)	TGCTCTGCTGCCTGGTGGGCA	0.622													37	56	---	---	---	---					
PCMTD1	115294	broad.mit.edu	37	8	52733063	52733063	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr8:52733063delT	ENST00000360540.5	-	7	1328	c.922delA	c.(922-924)atgfs	p.M308fs	PCMTD1_ENST00000519559.1_5'UTR|PCMTD1_ENST00000544451.1_Frame_Shift_Del_p.M232fs|PCMTD1_ENST00000522514.1_Frame_Shift_Del_p.M308fs	NM_052937.2	NP_443169.2	Q96MG8	PCMD1_HUMAN	protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1	308						cytoplasm	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity			NS(2)|endometrium(1)|kidney(3)|large_intestine(3)|lung(17)|prostate(2)|skin(8)|soft_tissue(1)	37		Lung NSC(129;0.0795)|all_lung(136;0.144)				tcctcttccattttttcatcc	0.373													8	132	---	---	---	---					
EPS8L2	64787	broad.mit.edu	37	11	722404	722404	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:722404delG	ENST00000533256.1	+	14	1438	c.1063delG	c.(1063-1065)gtcfs	p.V355fs	EPS8L2_ENST00000530636.1_Frame_Shift_Del_p.V355fs|EPS8L2_ENST00000526198.1_Frame_Shift_Del_p.V371fs|AP006621.9_ENST00000527021.2_RNA|EPS8L2_ENST00000318562.8_Frame_Shift_Del_p.V355fs			Q9H6S3	ES8L2_HUMAN	EPS8-like 2	355						cytoplasm				NS(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|pancreas(1)|prostate(2)|soft_tissue(1)|urinary_tract(1)	13		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;4.37e-27)|Epithelial(43;2.81e-26)|OV - Ovarian serous cystadenocarcinoma(40;1.33e-20)|BRCA - Breast invasive adenocarcinoma(625;4.29e-05)|Lung(200;0.0582)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GCCCCAGATCGTCAACACCTG	0.657													47	6	---	---	---	---					
TMED10	10972	broad.mit.edu	37	14	75601711	75601712	+	Splice_Site	INS	-	-	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:75601711_75601712insA	ENST00000303575.4	-	5	590		c.e5-2		RP11-950C14.7_ENST00000556236.1_RNA|TMED10_ENST00000557670.1_Splice_Site	NM_006827.5	NP_006818.3	P49755	TMEDA_HUMAN	transmembrane emp24-like trafficking protein 10 (yeast)						protein transport|regulated secretory pathway|vesicle targeting, to, from or within Golgi	cis-Golgi network|ER-Golgi intermediate compartment|Golgi membrane|integral to membrane|melanosome|microsome|zymogen granule membrane	protein binding			endometrium(1)|large_intestine(5)|lung(3)	9				BRCA - Breast invasive adenocarcinoma(234;0.0126)		TTGTTGACTCTAAAAAAAAACA	0.426													8	99	---	---	---	---					
EXOC3L4	91828	broad.mit.edu	37	14	103566640	103566640	+	Frame_Shift_Del	DEL	C	C	-			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:103566640delC	ENST00000380069.3	+	1	160	c.84delC	c.(82-84)ggcfs	p.G28fs		NM_001077594.1	NP_001071062.1	Q17RC7	EX3L4_HUMAN	exocyst complex component 3-like 4	28										cervix(2)|endometrium(2)|lung(4)|ovary(1)|skin(1)	10						CAGCTCAGGGCTCCCGGCGAA	0.657													7	15	---	---	---	---					
PKD1L2	114780	broad.mit.edu	37	16	81232364	81232364	+	RNA	DEL	C	C	-			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:81232364delC	ENST00000337114.4	-	0	1445				PKD1L2_ENST00000525539.1_RNA	NM_001076780.1	NP_001070248.1	Q7Z442	PK1L2_HUMAN	polycystic kidney disease 1-like 2						neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						CCTCAAAGGTCAGCTCTTCCG	0.562													65	61	---	---	---	---					
QTRT1	81890	broad.mit.edu	37	19	10822952	10822953	+	Frame_Shift_Ins	INS	-	-	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:10822952_10822953insC	ENST00000250237.5	+	6	772_773	c.762_763insC	c.(763-765)cccfs	p.P255fs		NM_031209.2	NP_112486.1	Q9BXR0	TGT_HUMAN	queuine tRNA-ribosyltransferase 1	255					queuosine biosynthetic process	mitochondrion|nucleus|ribosome	metal ion binding|queuine tRNA-ribosyltransferase activity			large_intestine(2)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	12			Epithelial(33;1.55e-05)|all cancers(31;3.42e-05)			CGAAGGACAAGCCCCGATATCT	0.639													39	318	---	---	---	---					
CILP2	148113	broad.mit.edu	37	19	19650559	19650559	+	Frame_Shift_Del	DEL	C	C	-			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:19650559delC	ENST00000586018.1	+	2	238	c.136delC	c.(136-138)cccfs	p.P46fs	CILP2_ENST00000291495.5_Frame_Shift_Del_p.P46fs			Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	46						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(17)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	32						CACCGGCCAGCCCTCACCAGC	0.667													72	104	---	---	---	---					
TPRX1	284355	broad.mit.edu	37	19	48305975	48305975	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:48305975delG	ENST00000535759.1	-	4	583	c.584delC	c.(583-585)ccgfs	p.P195fs	TPRX1_ENST00000322175.3_Frame_Shift_Del_p.P98fs|TPRX1_ENST00000543508.1_Frame_Shift_Del_p.P98fs			Q8N7U7	TPRX1_HUMAN	tetra-peptide repeat homeobox 1	98	Gly-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(5)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|prostate(2)|skin(1)	18		all_cancers(25;3.02e-09)|all_epithelial(76;7e-07)|all_lung(116;2.48e-06)|Lung NSC(112;5.15e-06)|Ovarian(192;0.0139)|all_neural(266;0.0146)|Breast(70;0.133)		OV - Ovarian serous cystadenocarcinoma(262;0.000241)|all cancers(93;0.00036)|Epithelial(262;0.0127)|GBM - Glioblastoma multiforme(486;0.048)		ggcagggATCGGGCCAGGGCC	0.687													4	4	---	---	---	---					
PPFIA3	8541	broad.mit.edu	37	19	49649253	49649253	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:49649253delG	ENST00000334186.4	+	22	3148	c.2799delG	c.(2797-2799)acgfs	p.T934fs	PPFIA3_ENST00000602351.1_Frame_Shift_Del_p.T934fs	NM_003660.2	NP_003651.1	O75145	LIPA3_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3	934						cell surface|cytoplasm	protein binding			NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(16)|pancreas(1)|prostate(1)|skin(4)|urinary_tract(1)	35		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.36e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000203)|GBM - Glioblastoma multiforme(486;0.00307)|Epithelial(262;0.00677)		TTACGGCCACGACCAAGCCCG	0.642											OREG0025618	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	50	54	---	---	---	---					
SIGLEC8	27181	broad.mit.edu	37	19	51961617	51961619	+	In_Frame_Del	DEL	GCA	GCA	-			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:51961617_51961619delGCA	ENST00000321424.3	-	1	89_91	c.23_25delTGC	c.(22-27)ctgccc>ccc	p.L8del	SIGLEC8_ENST00000340550.5_In_Frame_Del_p.L8del|SIGLEC8_ENST00000430817.1_In_Frame_Del_p.L8del	NM_014442.2	NP_055257.2	Q9NYZ4	SIGL8_HUMAN	sialic acid binding Ig-like lectin 8	8					cell adhesion	integral to membrane	sugar binding|transmembrane receptor activity			NS(1)|central_nervous_system(3)|endometrium(2)|kidney(4)|large_intestine(11)|liver(3)|lung(15)|ovary(2)|skin(4)|stomach(3)|urinary_tract(2)	50		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000627)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		CAGagcaggggcagcagcagcag	0.596													7	100	---	---	---	---					
TRIB3	57761	broad.mit.edu	37	20	377174	377174	+	Frame_Shift_Del	DEL	C	C	-			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:377174delC	ENST00000217233.3	+	4	1470	c.917delC	c.(916-918)gccfs	p.A306fs	TRIB3_ENST00000422053.2_Frame_Shift_Del_p.A333fs	NM_021158.3	NP_066981.2	Q96RU7	TRIB3_HUMAN	tribbles pseudokinase 3	306	Protein kinase.				apoptosis|cellular lipid metabolic process|insulin receptor signaling pathway|negative regulation of fat cell differentiation|negative regulation of fatty acid biosynthetic process|negative regulation of protein kinase activity|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of protein binding|positive regulation of ubiquitin-protein ligase activity|regulation of glucose transport|regulation of MAP kinase activity|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	ATP binding|protein kinase activity|protein kinase binding|protein kinase inhibitor activity|transcription corepressor activity|ubiquitin protein ligase binding|ubiquitin-protein ligase regulator activity			breast(1)|central_nervous_system(3)|endometrium(2)|large_intestine(3)|lung(9)|ovary(2)|skin(1)	21		all_epithelial(17;0.165)|Lung NSC(37;0.191)|Breast(17;0.231)		Colorectal(46;0.101)|COAD - Colon adenocarcinoma(99;0.112)		CGGCTCACAGCCACAGGCATC	0.687													45	197	---	---	---	---					
SPTLC3	55304	broad.mit.edu	37	20	13134777	13134777	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:13134777delT	ENST00000399002.2	+	10	1681	c.1407delT	c.(1405-1407)ggtfs	p.G469fs	SPTLC3_ENST00000378194.4_3'UTR	NM_018327.2	NP_060797.2	Q9NUV7	SPTC3_HUMAN	serine palmitoyltransferase, long chain base subunit 3	469					sphingoid biosynthetic process	integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			breast(1)|endometrium(1)|large_intestine(7)|lung(14)|skin(1)|urinary_tract(1)	25					Pyridoxal Phosphate(DB00114)	ATATGCCTGGTAAAGTAGCGT	0.408													32	87	---	---	---	---					
ZNFX1	57169	broad.mit.edu	37	20	47864087	47864088	+	In_Frame_Ins	INS	-	-	GGC			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:47864087_47864088insGGC	ENST00000396105.1	-	14	5719_5720	c.5473_5474insGCC	c.(5473-5475)ctg>cGCCtg	p.1824_1825insR	ZNFX1_ENST00000371752.1_In_Frame_Ins_p.1824_1825insR|ZNFX1_ENST00000371754.4_Intron	NM_021035.2	NP_066363.1	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	1824							metal ion binding			cervix(2)|endometrium(8)|kidney(7)|large_intestine(15)|liver(1)|lung(17)|ovary(2)|prostate(4)|skin(3)|urinary_tract(1)	60			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			TGAGATGCCCAGGCCAGAGCAG	0.495													42	145	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11049668	11049668	+	RNA	DEL	T	T	-			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr21:11049668delT	ENST00000470054.1	-	0	487									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		AGAATTTAAATTTTTTCTGAC	0.338													12	163	---	---	---	---					
KDM6A	7403	broad.mit.edu	37	X	44918557	44918558	+	Frame_Shift_Ins	INS	-	-	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chrX:44918557_44918558insG	ENST00000377967.4	+	12	1081_1082	c.1040_1041insG	c.(1039-1044)ttggacfs	p.D348fs	KDM6A_ENST00000382899.4_Frame_Shift_Ins_p.D348fs|KDM6A_ENST00000543216.1_Frame_Shift_Ins_p.D348fs|KDM6A_ENST00000536777.1_Frame_Shift_Ins_p.D348fs	NM_021140.2	NP_066963.2	O15550	KDM6A_HUMAN	lysine (K)-specific demethylase 6A	348					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.0?(6)|p.0(2)		NS(1)|breast(7)|central_nervous_system(27)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(24)|kidney(24)|large_intestine(9)|liver(1)|lung(21)|oesophagus(11)|pancreas(2)|prostate(5)|skin(1)|soft_tissue(1)|urinary_tract(29)	170						GCTGTACAATTGGACCATGGCC	0.431			"""D, N, F, S"""		"""renal, oesophageal SCC, MM"""								39	9	---	---	---	---					
STAG2	10735	broad.mit.edu	37	X	123184129	123184130	+	Frame_Shift_Del	DEL	AA	AA	-			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chrX:123184129_123184130delAA	ENST00000371160.1	+	11	1277_1278	c.987_988delAA	c.(985-990)ttaaaafs	p.K330fs	STAG2_ENST00000218089.9_Frame_Shift_Del_p.K330fs|STAG2_ENST00000371157.3_Frame_Shift_Del_p.K330fs|STAG2_ENST00000371144.3_Frame_Shift_Del_p.K330fs|STAG2_ENST00000371145.3_Frame_Shift_Del_p.K330fs|STAG2_ENST00000354548.5_Frame_Shift_Del_p.K261fs|STAG2_ENST00000469481.1_Intron	NM_001282418.1	NP_001269347.1	Q8N3U4	STAG2_HUMAN	stromal antigen 2	330	SCD.				cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(9)|lung(21)|ovary(5)|prostate(2)|skin(5)|urinary_tract(4)	78						ACAGTTATTTAAAATATGTTGG	0.401													141	18	---	---	---	---