Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
NAV2	89797	broad.mit.edu	37	11	19901579	19901579	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr11:19901579C>T	ENST00000396085.1	+	5	1037	c.676C>T	c.(676-678)Cag>Tag	p.Q226*	NAV2_ENST00000396087.3_Nonsense_Mutation_p.Q226*|NAV2_ENST00000349880.4_Nonsense_Mutation_p.Q226*|NAV2_ENST00000534229.1_3'UTR|NAV2_ENST00000540292.1_Nonsense_Mutation_p.Q157*|NAV2_ENST00000360655.4_Nonsense_Mutation_p.Q162*|NAV2_ENST00000527559.2_Nonsense_Mutation_p.Q155*	NM_182964.5	NP_892009.3	Q8IVL1	NAV2_HUMAN	neuron navigator 2	226	Gln-rich.					nucleus	ATP binding|helicase activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(26)|lung(38)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	116						TGGCACCCCTCAGCAGCAGGT	0.677000													21	66					0	0	0.008871	0	0
ASH1L	55870	broad.mit.edu	37	1	155408773	155408773	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr1:155408773C>T	ENST00000368346.3	-	5	5812	c.5173G>A	c.(5173-5175)Gag>Aag	p.E1725K	ASH1L_ENST00000392403.3_Missense_Mutation_p.E1725K			Q9NR48	ASH1L_HUMAN	ash1 (absent, small, or homeotic)-like (Drosophila)	1725	Ser-rich.				cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(13)|large_intestine(28)|lung(39)|ovary(2)|pancreas(1)|prostate(6)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(4)	124	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			TCTTGGTCCTCATTTTGTACC	0.502000													21	90					0	0	0.008871	0	0
SLC6A19	340024	broad.mit.edu	37	5	1208934	1208934	+	Silent	SNP	C	C	T	rs146678323	byFrequency	TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr5:1208934C>T	ENST00000304460.10	+	2	332	c.276C>T	c.(274-276)atC>atT	p.I92I		NM_001003841.2	NP_001003841.1	Q695T7	S6A19_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 19	92					cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|lung(25)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	44	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			AGTTCGCCATCGGGCAGCGGC	0.667000													15	132					0	0	0.004007	0	0
PSD2	84249	broad.mit.edu	37	5	139221900	139221900	+	Silent	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr5:139221900C>T	ENST00000274710.3	+	15	2362	c.2157C>T	c.(2155-2157)atC>atT	p.I719I		NM_032289.2	NP_115665.1	Q9BQI7	PSD2_HUMAN	pleckstrin and Sec7 domain containing 2	719					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(10)|liver(2)|lung(15)|ovary(1)|prostate(2)	38			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTATGAAAATCAAAGTGGGCT	0.498000													7	61					0	0	0.001984	0	0
DDX59	83479	broad.mit.edu	37	1	200635525	200635525	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr1:200635525C>T	ENST00000447706.2	-	2	495	c.344G>A	c.(343-345)gGa>gAa	p.G115E	DDX59_ENST00000367348.3_Missense_Mutation_p.G115E|DDX59_ENST00000331314.6_Missense_Mutation_p.G115E			Q5T1V6	DDX59_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 59	115						intracellular	ATP binding|ATP-dependent helicase activity|metal ion binding|RNA binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(2)|liver(1)|lung(9)|ovary(3)	21						GATATACTCTCCATAACGACC	0.433000													18	116					0	0	0.004990	0	0
BCAS2	10286	broad.mit.edu	37	1	115118317	115118317	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr1:115118317C>G	ENST00000369541.3	-	4	360	c.313G>C	c.(313-315)Gaa>Caa	p.E105Q	BCAS2_ENST00000485021.1_5'UTR	NM_005872.2	NP_005863.1	O75934	SPF27_HUMAN	breast carcinoma amplified sequence 2	105					mRNA processing|RNA splicing, via transesterification reactions	nucleolus|spliceosomal complex	protein binding			biliary_tract(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(4)	13	all_epithelial(7;9.54e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		TTTACACATTCTTGCCATGCA	0.373000													24	120					0	0	0.003954	0	0
STXBP4	252983	broad.mit.edu	37	17	53124492	53124492	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr17:53124492G>C	ENST00000376352.2	+	12	1195	c.988G>C	c.(988-990)Gaa>Caa	p.E330Q	STXBP4_ENST00000434978.2_Intron	NM_178509.5	NP_848604.3	Q6ZWJ1	STXB4_HUMAN	syntaxin binding protein 4	330						cytoplasm	calcium ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(4)|ovary(1)|upper_aerodigestive_tract(2)	19						ACAATTGACAGAAGAGCTCCA	0.333000													6	49					0	0	0.001168	0	0
TGIF2LX	90316	broad.mit.edu	37	X	89177511	89177511	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chrX:89177511C>T	ENST00000561129.2	+	1	557	c.427C>T	c.(427-429)Ccg>Tcg	p.P143S	TGIF2LX_ENST00000283891.5_Missense_Mutation_p.P143S			Q8IUE1	TF2LX_HUMAN	TGFB-induced factor homeobox 2-like, X-linked	143						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.P143S(1)		central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(29)|ovary(1)|skin(3)|urinary_tract(1)	40						GGCGTCTGTGCCGGCCAAGTC	0.587000													4	74					0	0	0.000248	0	0
KLB	152831	broad.mit.edu	37	4	39409050	39409050	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr4:39409050G>T	ENST00000257408.4	+	1	578	c.481G>T	c.(481-483)Gat>Tat	p.D161Y		NM_175737.3	NP_783864.1	Q86Z14	KLOTB_HUMAN	klotho beta	161	Glycosyl hydrolase-1 1.				carbohydrate metabolic process	integral to membrane|plasma membrane	cation binding|fibroblast growth factor binding|hydrolase activity, hydrolyzing O-glycosyl compounds			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(11)|skin(6)	29						GCTTTTCCCCGATGGAATAGT	0.378000													22	165					5.26018e-13	1.04144e-12	0.001882	1	0
EZR	7430	broad.mit.edu	37	6	159205678	159205678	+	Silent	SNP	G	G	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr6:159205678G>A	ENST00000367075.3	-	6	717	c.549C>T	c.(547-549)ctC>ctT	p.L183L	EZR_ENST00000337147.7_Silent_p.L183L|EZR_ENST00000392177.4_Silent_p.L151L|EZR_ENST00000476189.1_5'UTR	NM_001111077.1	NP_001104547.1	P15311	EZRI_HUMAN	ezrin	183	FERM.				actin filament bundle assembly|axon guidance|cytoskeletal anchoring at plasma membrane|leukocyte cell-cell adhesion|membrane to membrane docking|regulation of cell shape	actin filament|apical plasma membrane|basolateral plasma membrane|cortical cytoskeleton|cytosol|extrinsic to membrane|filopodium|microvillus membrane|nucleolus|ruffle membrane	actin filament binding|cell adhesion molecule binding		EZR/ROS1(4)	breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(2)|lung(1)|ovary(1)|prostate(2)	15		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-17)|BRCA - Breast invasive adenocarcinoma(81;6.58e-06)		GCACTCACTTGAGCATCCCAC	0.542000			T	ROS1	NSCLC								6	45					0	0	0.003080	0	0
MOB3B	79817	broad.mit.edu	37	9	27455341	27455341	+	Silent	SNP	G	G	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr9:27455341G>T	ENST00000262244.5	-	2	632	c.208C>A	c.(208-210)Cgg>Agg	p.R70R		NM_024761.4	NP_079037.3	Q86TA1	MOL2B_HUMAN	MOB kinase activator 3B	70							metal ion binding|protein binding	p.R70W(1)									AGGTTGATCCGATTGAAGAAG	0.562000													25	138					3.01185e-09	5.8262e-09	0.003954	1	0
ACTB	60	broad.mit.edu	37	7	5567777	5567777	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr7:5567777G>C	ENST00000331789.5	-	5	1033	c.842C>G	c.(841-843)tCc>tGc	p.S281C	AC006483.1_ENST00000579427.1_RNA	NM_001101.3	NP_001092.1	P60709	ACTB_HUMAN	actin, beta	281					'de novo' posttranslational protein folding|adherens junction organization|axon guidance|blood coagulation|cell junction assembly|cellular component movement	cytoskeleton|cytosol|MLL5-L complex|NuA4 histone acetyltransferase complex|ribonucleoprotein complex	ATP binding|kinesin binding|nitric-oxide synthase binding|structural constituent of cytoskeleton			NS(1)|central_nervous_system(1)|large_intestine(2)|lung(2)|prostate(2)	8		Ovarian(82;0.0606)		UCEC - Uterine corpus endometrioid carcinoma (126;0.175)|OV - Ovarian serous cystadenocarcinoma(56;4.24e-37)		CTTCATGATGGAGTTGAAGGT	0.567000													33	237					0	0	0.003271	0	0
GLB1L2	89944	broad.mit.edu	37	11	134243652	134243652	+	Silent	SNP	G	G	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr11:134243652G>A	ENST00000535456.2	+	16	1733	c.1545G>A	c.(1543-1545)ctG>ctA	p.L515L	GLB1L2_ENST00000389881.3_Silent_p.L515L|GLB1L2_ENST00000339772.7_Silent_p.L515L|GLB1L2_ENST00000529077.1_3'UTR	NM_138342.3	NP_612351.2	Q8IW92	GLBL2_HUMAN	galactosidase, beta 1-like 2	515					carbohydrate metabolic process	extracellular region	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(20)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41	all_hematologic(175;0.127)	all_cancers(12;2.85e-18)|all_epithelial(12;1.21e-12)|all_lung(97;0.000276)|Lung NSC(97;0.000518)|Breast(109;0.00122)|Medulloblastoma(222;0.0399)|all_neural(223;0.0412)|Esophageal squamous(93;0.0844)		Epithelial(10;1.37e-11)|all cancers(11;2.2e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000885)|Lung(977;0.223)		ATTCACCCCTGAAAAACTTCA	0.542000													35	285					0	0	0.003271	0	0
RADIL	55698	broad.mit.edu	37	7	4856876	4856876	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr7:4856876G>A	ENST00000536091.1	-	6	1693	c.1561C>T	c.(1561-1563)Ctc>Ttc	p.L521F	RADIL_ENST00000538469.1_Silent_p.V334V|RADIL_ENST00000399583.3_Silent_p.V574V			Q96JH8	RADIL_HUMAN	Ras association and DIL domains	902	Dilute.				cell adhesion|multicellular organismal development|signal transduction		protein binding			NS(1)|biliary_tract(2)|breast(1)|central_nervous_system(3)|endometrium(2)|large_intestine(2)|lung(22)|pancreas(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)		GCACCTTGGAGACATAGTAGA	0.617000													11	99					0	0	0.000978	0	0
GBP4	115361	broad.mit.edu	37	1	89654362	89654362	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr1:89654362C>G	ENST00000355754.6	-	8	1410	c.1313G>C	c.(1312-1314)aGa>aCa	p.R438T		NM_052941.4	NP_443173.2	Q96PP9	GBP4_HUMAN	guanylate binding protein 4	438						cytoplasm	GTP binding|GTPase activity			central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(19)|skin(1)|stomach(2)|urinary_tract(1)	33				all cancers(265;0.00723)|Epithelial(280;0.0291)		GAAAATTCCTCTCAAAATGCT	0.448000													38	430					0	0	0.003755	0	0
EPHB3	2049	broad.mit.edu	37	3	184297327	184297327	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr3:184297327C>T	ENST00000330394.2	+	10	2316	c.1864C>T	c.(1864-1866)Cgg>Tgg	p.R622W	EIF2B5_ENST00000444495.1_Intron	NM_004443.3	NP_004434.2	P54753	EPHB3_HUMAN	EPH receptor B3	622						integral to plasma membrane	ATP binding|ephrin receptor activity			breast(5)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(22)|ovary(5)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	51	all_cancers(143;1.89e-10)|Ovarian(172;0.0339)		Epithelial(37;1.27e-34)|OV - Ovarian serous cystadenocarcinoma(80;3.8e-22)			TGAGGCTGTTCGGGAGTTTGC	0.547000													6	97					0	0	0.001168	0	0
LAMA2	3908	broad.mit.edu	37	6	129419396	129419396	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr6:129419396G>C	ENST00000421865.2	+	4	524	c.475G>C	c.(475-477)Gat>Cat	p.D159H		NM_000426.3|NM_001079823.1	NP_000417|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	159	Laminin N-terminal.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		ACGCTCTCTTGATGATGTTGA	0.493000													23	98					0	0	0.003954	0	0
DRGX	644168	broad.mit.edu	37	10	50574201	50574201	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr10:50574201G>C	ENST00000374139.2	-	6	762	c.752C>G	c.(751-753)tCt>tGt	p.S251C	DRGX_ENST00000434016.1_Missense_Mutation_p.S256C			C9JW76	C9JW76_HUMAN	dorsal root ganglia homeobox	256					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)	11						CTTGGTGGGAGAGGTCTTTTC	0.677000													8	103					0	0	0.003080	0	0
PAH	5053	broad.mit.edu	37	12	103246681	103246681	+	Missense_Mutation	SNP	G	G	C	rs5030847		TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr12:103246681G>C	ENST00000553106.1	-	7	1226	c.754C>G	c.(754-756)Cgg>Ggg	p.R252G	PAH_ENST00000307000.2_Missense_Mutation_p.R247G	NM_000277.1	NP_000268.1	P00439	PH4H_HUMAN	phenylalanine hydroxylase	252			R -> G (in PKU; haplotype 7).|R -> Q (in PKU; haplotype 1).|R -> W (in PKU; haplotypes 1,6,7,8,42, 69; complete loss of activity).		catecholamine biosynthetic process|L-phenylalanine catabolic process|neurotransmitter biosynthetic process	cytosol	phenylalanine 4-monooxygenase activity			endometrium(1)|kidney(3)|large_intestine(5)|lung(10)|ovary(5)|skin(2)|urinary_tract(1)	27					Epinephrine(DB00668)|L-Phenylalanine(DB00120)|Levodopa(DB01235)|Norepinephrine(DB00368)|Tetrahydrobiopterin(DB00360)	AAGAAATCCCGAGAGGAAAGC	0.537000													4	250					0	0	0.000248	0	0
MCCC1	56922	broad.mit.edu	37	3	182763229	182763229	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr3:182763229C>A	ENST00000492597.1	-	9	1430	c.728G>T	c.(727-729)gGa>gTa	p.G243V	MCCC1_ENST00000265594.4_Missense_Mutation_p.G352V|MCCC1_ENST00000539926.1_Missense_Mutation_p.G217V			Q96RQ3	MCCA_HUMAN	methylcrotonoyl-CoA carboxylase 1 (alpha)	352	ATP-grasp.|Biotin carboxylation.				biotin metabolic process|leucine catabolic process	mitochondrial inner membrane|mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|methylcrotonoyl-CoA carboxylase activity			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(9)|liver(1)|lung(17)|ovary(1)|pancreas(2)|prostate(1)|skin(2)	40	all_cancers(143;1.84e-14)|Ovarian(172;0.0355)		all cancers(12;1.8e-44)|Epithelial(37;3.23e-38)|LUSC - Lung squamous cell carcinoma(7;5.04e-25)|Lung(8;5.03e-23)|OV - Ovarian serous cystadenocarcinoma(80;5.07e-21)		Biotin(DB00121)	CAAGTCAGTTCCTGTGATCAT	0.438000													19	168					3.51602e-12	6.89186e-12	0.008871	1	0
PALD1	27143	broad.mit.edu	37	10	72299450	72299450	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr10:72299450C>T	ENST00000263563.6	+	15	2108	c.1840C>T	c.(1840-1842)Cgc>Tgc	p.R614C		NM_014431.2	NP_055246.2			phosphatase domain containing, paladin 1																		CAGCCAGCACCGCAGGGCCTG	0.662000													17	101					0	0	0.004990	0	0
COG5	10466	broad.mit.edu	37	7	106938618	106938618	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr7:106938618C>G	ENST00000393603.2	-	12	1646	c.1375G>C	c.(1375-1377)Gat>Cat	p.D459H	COG5_ENST00000347053.3_Missense_Mutation_p.D459H|COG5_ENST00000297135.3_Missense_Mutation_p.D459H	NM_001161520.1	NP_001154992.1	Q9UP83	COG5_HUMAN	component of oligomeric golgi complex 5	459					intra-Golgi vesicle-mediated transport|protein transport	cytosol|Golgi membrane|Golgi transport complex|nucleus	protein binding			breast(3)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(17)|ovary(2)|skin(4)|stomach(1)	40						ATGAATATATCTTGTGCATCA	0.313000													19	134					0	0	0.001882	0	0
ZBTB22	9278	broad.mit.edu	37	6	33282841	33282841	+	Missense_Mutation	SNP	G	G	C	rs147609143		TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr6:33282841G>C	ENST00000431845.2	-	2	2004	c.1853C>G	c.(1852-1854)cCc>cGc	p.P618R	ZBTB22_ENST00000418724.1_Missense_Mutation_p.P618R	NM_005453.4	NP_005444.4	O15209	ZBT22_HUMAN	zinc finger and BTB domain containing 22	618					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(9)|ovary(2)|prostate(1)|urinary_tract(3)	21						GTGGACTCTGGGTGGGGACCA	0.647000													14	96					0	0	0.004007	0	0
ERBB2	2064	broad.mit.edu	37	17	37866352	37866352	+	Silent	SNP	C	C	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr17:37866352C>A	ENST00000406381.2	+	8	1077	c.567C>A	c.(565-567)gtC>gtA	p.V189V	ERBB2_ENST00000541774.1_Silent_p.V204V|ERBB2_ENST00000445658.2_Intron|ERBB2_ENST00000578199.1_Silent_p.V189V|ERBB2_ENST00000540042.1_Silent_p.V189V|ERBB2_ENST00000584601.1_Silent_p.V189V|ERBB2_ENST00000269571.5_Silent_p.V219V|ERBB2_ENST00000540147.1_Silent_p.V189V|ERBB2_ENST00000584450.1_Silent_p.V219V	NM_001005862.1	NP_001005862.1	P04626	ERBB2_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2	219					cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			NS(1)|breast(16)|central_nervous_system(17)|endometrium(6)|haematopoietic_and_lymphoid_tissue(8)|kidney(4)|large_intestine(16)|liver(3)|lung(125)|ovary(18)|pancreas(1)|prostate(4)|skin(1)|stomach(14)|upper_aerodigestive_tract(9)|urinary_tract(4)	247	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	CGCGCACTGTCTGTGCCGGTG	0.657000		1	"""A, Mis, O"""		"""breast, ovarian, other tumour types, NSCLC, gastric"""					TCGA GBM(5;<1E-08)			25	161					2.12542e-12	4.17998e-12	0.006320	1	0
CUX2	23316	broad.mit.edu	37	12	111758153	111758153	+	Silent	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr12:111758153C>T	ENST00000261726.6	+	17	2494	c.2340C>T	c.(2338-2340)ggC>ggT	p.G780G		NM_015267.3	NP_056082.2	O14529	CUX2_HUMAN	cut-like homeobox 2	780						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(24)|ovary(5)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	55						CCGAGATCGGCGACGCCGGCT	0.726000													7	234					0	0	0.003080	0	0
PAXBP1	94104	broad.mit.edu	37	21	34107329	34107329	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr21:34107329C>G	ENST00000331923.4	-	18	2875	c.2686G>C	c.(2686-2688)Gat>Cat	p.D896H	PAXBP1-AS1_ENST00000440052.1_RNA|PAXBP1-AS1_ENST00000455170.1_RNA	NM_016631.3	NP_057715.2			PAX3 and PAX7 binding protein 1																		ATAGCATGATCCAAAGCTCGA	0.323000													10	46					0	0	0.006214	0	0
ZZEF1	23140	broad.mit.edu	37	17	3921190	3921190	+	Silent	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr17:3921190C>T	ENST00000381638.2	-	47	7705	c.7581G>A	c.(7579-7581)ctG>ctA	p.L2527L		NM_015113.3	NP_055928.3	O43149	ZZEF1_HUMAN	zinc finger, ZZ-type with EF-hand domain 1	2527							calcium ion binding|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	84						CTTCCAGCCTCAGACTCTTAC	0.537000													15	72					0	0	0.002450	0	0
AFAP1	60312	broad.mit.edu	37	4	7774605	7774605	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr4:7774605G>A	ENST00000420658.1	-	16	2467	c.2195C>T	c.(2194-2196)gCg>gTg	p.A732V	AFAP1_ENST00000358461.2_Missense_Mutation_p.A648V|AFAP1_ENST00000382543.3_Missense_Mutation_p.A732V|AFAP1_ENST00000360265.4_Missense_Mutation_p.A648V|AFAP1_ENST00000513842.1_5'UTR|AFAP1-AS1_ENST00000608442.1_RNA	NM_001134647.1	NP_001128119.1	Q8N556	AFAP1_HUMAN	actin filament associated protein 1	652						actin cytoskeleton|cytoplasm|focal adhesion	actin binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|skin(4)|stomach(2)	32						GACTCCGCCCGCCAGCGCTTT	0.657000													4	49					0	0	0.000248	0	0
FAM214B	80256	broad.mit.edu	37	9	35107482	35107482	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr9:35107482T>C	ENST00000378561.1	-	2	3845	c.790A>G	c.(790-792)Agg>Ggg	p.R264G	FAM214B_ENST00000605244.1_Missense_Mutation_p.R264G|FAM214B_ENST00000378554.2_Missense_Mutation_p.R264G|FAM214B_ENST00000603301.1_Missense_Mutation_p.R264G|FAM214B_ENST00000378557.1_Missense_Mutation_p.R264G|FAM214B_ENST00000322813.5_Missense_Mutation_p.R264G|FAM214B_ENST00000488109.2_Missense_Mutation_p.R264G|FAM214B_ENST00000378566.1_5'UTR			Q7L5A3	K1539_HUMAN	family with sequence similarity 214, member B	264						nucleus											CCCCGGCGCCTCCGAGGGGCT	0.667000													5	282					0	0	0.000602	0	0
ZFP36L2	678	broad.mit.edu	37	2	43452225	43452225	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr2:43452225C>G	ENST00000282388.3	-	2	1011	c.718G>C	c.(718-720)Gat>Cat	p.D240H	THADA_ENST00000330266.7_Intron	NM_006887.4	NP_008818.3	P47974	TISD_HUMAN	ZFP36 ring finger protein-like 2	240					cell proliferation	nucleus	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.D240N(2)		breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	15		Acute lymphoblastic leukemia(82;0.00323)|all_hematologic(82;0.00824)				TGCAACGCATCGCGCGTGCCA	0.746000													8	20					0	0	0.003080	0	0
ZNF524	147807	broad.mit.edu	37	19	56113616	56113616	+	Silent	SNP	C	C	G			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr19:56113616C>G	ENST00000591046.1	+	1	372	c.138C>G	c.(136-138)ctC>ctG	p.L46L	ZNF524_ENST00000301073.3_Silent_p.L46L			Q96C55	ZN524_HUMAN	zinc finger protein 524	46					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|large_intestine(2)|lung(6)|prostate(1)	10			BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.105)		ATCGGACACTCAAGGCCTCCC	0.692000													5	32					0	0	0.000602	0	0
PAXBP1	94104	broad.mit.edu	37	21	34134626	34134626	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr21:34134626C>T	ENST00000331923.4	-	4	841	c.652G>A	c.(652-654)Gaa>Aaa	p.E218K	PAXBP1_ENST00000472588.1_5'UTR|PAXBP1_ENST00000290178.4_Missense_Mutation_p.E218K	NM_016631.3	NP_057715.2			PAX3 and PAX7 binding protein 1																		TCTGGAATTTCTCCTAGAAAC	0.388000													7	33					0	0	0.001984	0	0
MLC1	23209	broad.mit.edu	37	22	50506964	50506964	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr22:50506964T>C	ENST00000311597.5	-	10	1398	c.792A>G	c.(790-792)atA>atG	p.I264M	MLC1_ENST00000535444.1_Missense_Mutation_p.I185M|MLC1_ENST00000450140.2_Missense_Mutation_p.I212M|MLC1_ENST00000483836.1_5'UTR|MLC1_ENST00000431262.2_Missense_Mutation_p.I234M|MLC1_ENST00000395876.2_Missense_Mutation_p.I264M|MLC1_ENST00000538737.1_Missense_Mutation_p.I230M	NM_015166.3	NP_055981.1	Q15049	MLC1_HUMAN	megalencephalic leukoencephalopathy with subcortical cysts 1	264						basolateral plasma membrane|endosome|integral to membrane|integral to membrane of membrane fraction	ion channel activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(7)|pancreas(1)|prostate(3)	18		all_cancers(38;7.69e-11)|all_epithelial(38;9.52e-10)|all_lung(38;3.67e-05)|Breast(42;0.000776)|Lung NSC(38;0.000946)|Ovarian(80;0.0365)|Lung SC(80;0.113)		READ - Rectum adenocarcinoma(2;0.000669)|Colorectal(2;0.00242)|LUAD - Lung adenocarcinoma(64;0.0695)|BRCA - Breast invasive adenocarcinoma(115;0.216)		TGAGGCTGCTTATGGCAATCA	0.592000													31	181					0	0	0.001786	0	0
UTP20	27340	broad.mit.edu	37	12	101696246	101696246	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr12:101696246C>G	ENST00000261637.4	+	15	1870	c.1696C>G	c.(1696-1698)Caa>Gaa	p.Q566E		NM_014503.2	NP_055318.2	O75691	UTP20_HUMAN	UTP20, small subunit (SSU) processome component, homolog (yeast)	566					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			NS(3)|biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(26)|lung(30)|ovary(2)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	88						TGTTCTTTGTCAAGCTGTAAA	0.308000													11	126					0	0	0.000978	0	0
STK38L	23012	broad.mit.edu	37	12	27461378	27461378	+	Missense_Mutation	SNP	G	G	C	rs150452352		TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr12:27461378G>C	ENST00000389032.3	+	4	462	c.293G>C	c.(292-294)aGa>aCa	p.R98T	STK38L_ENST00000539577.1_Intron	NM_015000.3	NP_055815.1	Q9Y2H1	ST38L_HUMAN	serine/threonine kinase 38 like	98	Protein kinase.				intracellular protein kinase cascade|regulation of cellular component organization	actin cytoskeleton|cytoplasm	actin binding|ATP binding|magnesium ion binding|protein serine/threonine kinase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(2)|ovary(2)|prostate(1)|skin(1)	12	Colorectal(261;0.0847)					GTTATAGGAAGAGGAGCTTTT	0.373000													29	203					0	0	0.001786	0	0
SRRM2	23524	broad.mit.edu	37	16	2818064	2818064	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr16:2818064C>G	ENST00000301740.8	+	11	8084	c.7535C>G	c.(7534-7536)tCt>tGt	p.S2512C	SRRM2_ENST00000574593.1_3'UTR	NM_016333.3	NP_057417.3	Q9UQ35	SRRM2_HUMAN	serine/arginine repetitive matrix 2	2512	Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|lung(34)|ovary(6)|pancreas(3)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(7)	105						CCACCTGCCTCTACTGGGGCC	0.637000													10	54					0	0	0.008291	0	0
PDCL	5082	broad.mit.edu	37	9	125582591	125582591	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr9:125582591G>A	ENST00000259467.4	-	4	844	c.679C>T	c.(679-681)Cag>Tag	p.Q227*		NM_005388.4	NP_005379.3	Q13371	PHLP_HUMAN	phosducin-like	227					signal transduction|visual perception					endometrium(1)|large_intestine(2)|lung(5)|skin(1)|stomach(1)	10						CTGGTGAACTGACTGCTGGCG	0.517000													13	76					0	0	0.001855	0	0
ZNF534	147658	broad.mit.edu	37	19	52942411	52942411	+	Silent	SNP	G	G	A	rs113700997		TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr19:52942411G>A	ENST00000332323.6	+	4	1798	c.1737G>A	c.(1735-1737)gcG>gcA	p.A579A	ZNF534_ENST00000432303.2_Intron|ZNF534_ENST00000301085.4_Intron|ZNF534_ENST00000433050.1_Silent_p.A566A	NM_001143939.1	NP_001137411.1	Q76KX8	ZN534_HUMAN	zinc finger protein 534	579					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.A579A(4)		central_nervous_system(1)|lung(1)|prostate(1)|skin(1)	4						CACACCTTGCGCGACATAGGA	0.443000													5	47					0	0	0.001168	0	0
BTG4	54766	broad.mit.edu	37	11	111367977	111367977	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr11:111367977G>T	ENST00000525791.1	-	4	653	c.469C>A	c.(469-471)Cgt>Agt	p.R157S	BTG4_ENST00000356018.2_Missense_Mutation_p.R157S			Q9NY30	BTG4_HUMAN	B-cell translocation gene 4	157					cell cycle arrest|negative regulation of cell proliferation|neuron differentiation					large_intestine(2)|upper_aerodigestive_tract(1)	3		all_cancers(61;3.78e-13)|all_epithelial(67;5.29e-08)|Melanoma(852;3.15e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0204)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;1.22e-06)|BRCA - Breast invasive adenocarcinoma(274;1.72e-06)|all cancers(92;2.18e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0509)		GGAATGACACGAGGTTCCTTG	0.388000													25	142					3.28513e-13	6.52601e-13	0.003954	1	0
NAPSA	9476	broad.mit.edu	37	19	50865522	50865522	+	Silent	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr19:50865522C>T	ENST00000253719.2	-	2	340	c.132G>A	c.(130-132)ctG>ctA	p.L44L	NR1H2_ENST00000542413.1_Intron|NR1H2_ENST00000600978.1_Intron	NM_004851.1	NP_004842.1	O96009	NAPSA_HUMAN	napsin A aspartic peptidase	44					proteolysis	extracellular region	aspartic-type endopeptidase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|skin(3)	12		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00743)|GBM - Glioblastoma multiforme(134;0.0183)		TCCATCCCCTCAGTAGGTTCA	0.557000													18	49					0	0	0.006122	0	0
MUC16	94025	broad.mit.edu	37	19	9087344	9087344	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr19:9087344G>A	ENST00000397910.4	-	1	4674	c.4471C>T	c.(4471-4473)Cct>Tct	p.P1491S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	1491	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTGGACATAGGTGGAAAAATA	0.428000													38	225					0	0	0.005524	0	0
FRG1B	284802	broad.mit.edu	37	20	29633900	29633900	+	Missense_Mutation	SNP	A	A	G	rs60081496	by1000genomes	TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr20:29633900A>G	ENST00000278882.3	+	9	919	c.539A>G	c.(538-540)gAa>gGa	p.E180G	FRG1B_ENST00000358464.4_Missense_Mutation_p.E180G														p.E180G(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						TAAACAAGAGAACCAAATTGA	0.264000													10	176					0	0	0.004007	0	0
ANKRD20A8P	729171	broad.mit.edu	37	2	95522772	95522772	+	RNA	SNP	T	T	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr2:95522772T>C	ENST00000432432.2	-	0	255					NR_040113.1													p.E49G(1)									GCGCTCCACCTCCGCGGCGTC	0.682000													8	109					0	0	0.000978	0	0
PXDN	7837	broad.mit.edu	37	2	1643087	1643087	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr2:1643087G>A	ENST00000252804.4	-	20	4110	c.4060C>T	c.(4060-4062)Cgg>Tgg	p.R1354W		NM_012293.1	NP_036425.1	Q92626	PXDN_HUMAN	peroxidasin homolog (Drosophila)	1354					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity	p.R1354W(1)		breast(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(24)|lung(48)|ovary(3)|pancreas(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	112	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		GGTATTTTCCGTGGTCTTGTT	0.577000													5	28					0	0	0.001168	0	0
KRT5	3852	broad.mit.edu	37	12	52911913	52911913	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr12:52911913C>G	ENST00000252242.4	-	3	1195	c.805G>C	c.(805-807)Gag>Cag	p.E269Q		NM_000424.3	NP_000415.2	P13647	K2C5_HUMAN	keratin 5	269	Coil 1B.|Rod.				epidermis development|hemidesmosome assembly	cytosol|keratin filament	protein binding|structural constituent of cytoskeleton			endometrium(5)|kidney(1)|large_intestine(8)|lung(15)|prostate(4)|skin(2)	35				BRCA - Breast invasive adenocarcinoma(357;0.189)		AACTCATTCTCAGCAGTGGTA	0.498000													30	233					0	0	0.002096	0	0
INTS9	55756	broad.mit.edu	37	8	28695229	28695229	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr8:28695229G>A	ENST00000416984.2	-	4	622	c.263C>T	c.(262-264)gCg>gTg	p.A88V	INTS9_ENST00000397363.4_Missense_Mutation_p.A3V|INTS9_ENST00000521777.1_Missense_Mutation_p.A85V|INTS9_ENST00000521022.1_Missense_Mutation_p.A109V	NM_001145159.2	NP_001138631.1	Q9NV88	INT9_HUMAN	integrator complex subunit 9	109					snRNA processing	integrator complex	protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|pancreas(2)|prostate(1)|urinary_tract(2)	19		Ovarian(32;0.0439)		KIRC - Kidney renal clear cell carcinoma(542;0.127)|Kidney(114;0.152)		GTATGGCAGCGCCATCATACA	0.493000													13	53					0	0	0.001855	0	0
PCDHB5	26167	broad.mit.edu	37	5	140515200	140515200	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr5:140515200C>T	ENST00000231134.5	+	1	401	c.184C>T	c.(184-186)Cgg>Tgg	p.R62W		NM_015669.2	NP_056484.1	Q9Y5E4	PCDB5_HUMAN		62	Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|kidney(1)|large_intestine(18)|lung(25)|ovary(3)|prostate(6)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	81			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACTGGCCACTCGGGGCGCGCG	0.488000													9	96					0	0	0.006214	0	0
RGPD3	653489	broad.mit.edu	37	2	107049681	107049681	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr2:107049681T>C	ENST00000409886.3	-	16	2353	c.2266A>G	c.(2266-2268)Aac>Gac	p.N756D	RGPD3_ENST00000304514.7_Missense_Mutation_p.N756D	NM_001144013.1	NP_001137485.1	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	756					intracellular transport		binding	p.N756D(6)		breast(2)|central_nervous_system(1)|endometrium(50)|kidney(4)|lung(11)|ovary(1)|urinary_tract(2)	71						TCACTATAGTTTTCGAGTTCC	0.373000													6	569					0	0	0.001168	0	0
SLC35E3	55508	broad.mit.edu	37	12	69140310	69140310	+	Silent	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr12:69140310C>T	ENST00000398004.2	+	1	425	c.153C>T	c.(151-153)ttC>ttT	p.F51F		NM_018656.2	NP_061126.2	Q7Z769	S35E3_HUMAN	solute carrier family 35, member E3	51						integral to membrane				cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	12	Breast(13;2.31e-06)|Renal(347;0.0684)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00372)			TGGTGCACTTCGTGGTCACCT	0.552000													21	323					0	0	0.002299	0	0
XIRP1	165904	broad.mit.edu	37	3	39227951	39227951	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr3:39227951G>C	ENST00000340369.3	-	2	3214	c.2986C>G	c.(2986-2988)Cag>Gag	p.Q996E	XIRP1_ENST00000421646.1_Intron|XIRP1_ENST00000396251.1_Missense_Mutation_p.Q996E	NM_194293.2	NP_919269.2	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	996							actin binding			breast(4)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(14)|lung(22)|ovary(4)|pancreas(1)|prostate(2)|skin(6)	71				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		CCAATGGCCTGAGGAGGGCAA	0.592000													16	87					0	0	0.004990	0	0
EPS8L2	64787	broad.mit.edu	37	11	722438	722438	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr11:722438C>G	ENST00000533256.1	+	14	1472	c.1097C>G	c.(1096-1098)tCc>tGc	p.S366C	AP006621.9_ENST00000527021.2_RNA|EPS8L2_ENST00000318562.8_Missense_Mutation_p.S366C|EPS8L2_ENST00000526198.1_Missense_Mutation_p.S382C|EPS8L2_ENST00000530636.1_Missense_Mutation_p.S366C			Q9H6S3	ES8L2_HUMAN	EPS8-like 2	366						cytoplasm				NS(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|pancreas(1)|prostate(2)|soft_tissue(1)|urinary_tract(1)	13		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;4.37e-27)|Epithelial(43;2.81e-26)|OV - Ovarian serous cystadenocarcinoma(40;1.33e-20)|BRCA - Breast invasive adenocarcinoma(625;4.29e-05)|Lung(200;0.0582)|LUSC - Lung squamous cell carcinoma(625;0.0703)		ATCGCACGCTCCGTCTCCTGC	0.652000													16	63					0	0	0.004990	0	0
FBXO11	80204	broad.mit.edu	37	2	48063049	48063049	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr2:48063049C>T	ENST00000403359.3	-	5	751	c.679G>A	c.(679-681)Gaa>Aaa	p.E227K	FBXO11_ENST00000316377.4_Missense_Mutation_p.E143K|FBXO11_ENST00000402508.1_Missense_Mutation_p.E143K	NM_001190274.1	NP_001177203.1	Q86XK2	FBX11_HUMAN	F-box protein 11	227					ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|ubiquitin ligase complex	protein binding|protein-arginine N-methyltransferase activity|ubiquitin-protein ligase activity|zinc ion binding	p.0?(2)		endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	26		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			TTTGGATGTTCATACTCTTCT	0.313000			"""Mis, F, D"""		DLBCL								17	72					0	0	0.007413	0	0
SLC2A1	6513	broad.mit.edu	37	1	43395366	43395366	+	Silent	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr1:43395366C>T	ENST00000426263.3	-	6	943	c.765G>A	c.(763-765)aaG>aaA	p.K255K	SLC2A1_ENST00000475162.1_Intron|SLC2A1_ENST00000415851.2_Intron	NM_006516.2	NP_006507.2	P11166	GTR1_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 1	255					carbohydrate metabolic process|energy reserve metabolic process|regulation of insulin secretion|water-soluble vitamin metabolic process	integral to membrane|melanosome|membrane fraction|midbody	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(2)|large_intestine(1)|lung(2)|ovary(1)|pancreas(2)	13	Ovarian(52;0.00579)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0122)			Etomidate(DB00292)	TGGTGACCTTCTTCTCCCGCA	0.622000													13	160					0	0	0.001368	0	0
IRS1	3667	broad.mit.edu	37	2	227660388	227660388	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr2:227660388C>T	ENST00000305123.5	-	1	4087	c.3067G>A	c.(3067-3069)Gag>Aag	p.E1023K		NM_005544.2	NP_005535.1	P35568	IRS1_HUMAN	insulin receptor substrate 1						fibroblast growth factor receptor signaling pathway|glucose homeostasis|insulin receptor signaling pathway|negative regulation of insulin receptor signaling pathway|negative regulation of insulin secretion|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity	caveola|cytosol|insulin receptor complex|microsome|nucleus	insulin receptor binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase binding|protein kinase C binding|SH2 domain binding|transmembrane receptor protein tyrosine kinase adaptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(5)|kidney(4)|large_intestine(10)|lung(33)|ovary(6)|pancreas(1)|prostate(1)|urinary_tract(2)	69		Renal(207;0.023)|all_lung(227;0.0994)|all_hematologic(139;0.118)|Esophageal squamous(248;0.23)		Epithelial(121;3.03e-11)|all cancers(144;2.42e-08)|Lung(261;0.00712)|LUSC - Lung squamous cell carcinoma(224;0.0137)		AGGCTCACCTCCTCTGCAGCA	0.627000													17	93					0	0	0.004007	0	0
PPP5C	5536	broad.mit.edu	37	19	46891833	46891833	+	Silent	SNP	G	G	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr19:46891833G>C	ENST00000012443.4	+	11	1303	c.1200G>C	c.(1198-1200)cgG>cgC	p.R400R	PPP5C_ENST00000391919.1_Silent_p.R272R	NM_006247.3	NP_006238.1	P53041	PPP5_HUMAN	protein phosphatase 5, catalytic subunit	400	Catalytic.				mitosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein dephosphorylation|transcription, DNA-dependent	Golgi apparatus|nucleus	metal ion binding|protein binding|protein serine/threonine phosphatase activity|signal transducer activity			endometrium(4)|kidney(1)|large_intestine(5)|liver(2)|lung(4)|ovary(1)|pancreas(1)	18		Ovarian(192;0.0731)|all_neural(266;0.196)		OV - Ovarian serous cystadenocarcinoma(262;0.000196)|all cancers(93;0.00192)|GBM - Glioblastoma multiforme(486;0.0499)|Epithelial(262;0.0504)		TCAGCAAGCGGGGCGTGAGCT	0.617000													7	82					0	0	0.001984	0	0
UGT2B17	7367	broad.mit.edu	37	4	69433695	69433695	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr4:69433695G>C	ENST00000317746.2	-	1	550	c.508C>G	c.(508-510)Ctg>Gtg	p.L170V		NM_001077.3	NP_001068.1	O75795	UDB17_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B17	170					steroid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(14)|ovary(2)|prostate(1)	30						AGACTGTACAGAAAGGGTATG	0.438000													20	377					0	0	0.001523	0	0
GPRASP1	9737	broad.mit.edu	37	X	101911836	101911836	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chrX:101911836G>A	ENST00000537097.1	+	6	3808	c.2995G>A	c.(2995-2997)Gag>Aag	p.E999K	GPRASP1_ENST00000415986.1_Missense_Mutation_p.E999K|GPRASP1_ENST00000361600.5_Missense_Mutation_p.E999K|GPRASP1_ENST00000444152.1_Missense_Mutation_p.E999K|RP4-769N13.7_ENST00000602441.1_RNA	NM_001184727.1	NP_001171656.1	Q5JY77	GASP1_HUMAN	G protein-coupled receptor associated sorting protein 1	999	OPRD1-binding.					cytoplasm	protein binding			NS(1)|breast(3)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(10)|lung(29)|ovary(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						TGATGAAGATGAGGCCATAGT	0.517000													26	66					0	0	0.005443	0	0
SEC24C	9632	broad.mit.edu	37	10	75530719	75530719	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr10:75530719G>A	ENST00000339365.2	+	24	3313	c.3151G>A	c.(3151-3153)Gtg>Atg	p.V1051M	SEC24C_ENST00000345254.4_Missense_Mutation_p.V1051M|SEC24C_ENST00000411652.2_Missense_Mutation_p.V932M|SEC24C_ENST00000540668.1_Missense_Mutation_p.V299M|SEC24C_ENST00000535742.1_Missense_Mutation_p.V299M	NM_004922.3	NP_004913.2	P53992	SC24C_HUMAN	SEC24 family member C	1051					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(3)|lung(12)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	32	Prostate(51;0.0112)					GTAGCTTACCGTGGTGAAACA	0.478000													15	174					0	0	0.002450	0	0
ARMC6	93436	broad.mit.edu	37	19	19168395	19168395	+	Silent	SNP	C	C	G			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr19:19168395C>G	ENST00000535612.1	+	9	1896	c.1464C>G	c.(1462-1464)ctC>ctG	p.L488L	ARMC6_ENST00000546344.1_Silent_p.L395L|ARMC6_ENST00000392335.2_Silent_p.L463L|ARMC6_ENST00000392336.3_Silent_p.L488L|ARMC6_ENST00000269932.6_Silent_p.L463L	NM_001199196.1	NP_001186125.1	Q6NXE6	ARMC6_HUMAN	armadillo repeat containing 6	488							protein binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|liver(2)|lung(5)|ovary(1)|prostate(1)	14			OV - Ovarian serous cystadenocarcinoma(5;5.66e-06)|Epithelial(12;0.000391)			ATGTCGAGCTCCGAGAGCTGT	0.662000													13	64					0	0	0.001368	0	0
TSC2	7249	broad.mit.edu	37	16	2129298	2129298	+	Silent	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr16:2129298C>T	ENST00000219476.3	+	28	3783	c.3153C>T	c.(3151-3153)ctC>ctT	p.L1051L	TSC2_ENST00000350773.4_Silent_p.L1051L|TSC2_ENST00000439673.2_Silent_p.L971L|TSC2_ENST00000382538.6_Silent_p.L959L|TSC2_ENST00000568366.1_3'UTR|TSC2_ENST00000568454.1_Silent_p.L1018L|TSC2_ENST00000401874.2_Silent_p.L1007L|TSC2_ENST00000353929.4_Silent_p.L1008L	NM_000548.3	NP_000539.2	P49815	TSC2_HUMAN	tuberous sclerosis 2	1051					cell cycle arrest|endocytosis|heart development|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|negative regulation of cell size|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of protein kinase B signaling cascade|negative regulation of TOR signaling cascade|negative regulation of Wnt receptor signaling pathway|nerve growth factor receptor signaling pathway|neural tube closure|phosphatidylinositol-mediated signaling|positive chemotaxis|protein import into nucleus|protein kinase B signaling cascade|regulation of endocytosis|regulation of insulin receptor signaling pathway|regulation of small GTPase mediated signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm|TSC1-TSC2 complex	GTPase activator activity|protein homodimerization activity			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(3)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|soft_tissue(1)	56		Hepatocellular(780;0.0202)				GCGAGTTCCTCCTAGCGGGTG	0.637000			"""D, Mis, N, F, S"""			"""hamartoma, renal cell"""			Tuberous Sclerosis				10	92					0	0	0.006214	0	0
NAB1	4664	broad.mit.edu	37	2	191524410	191524410	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr2:191524410G>A	ENST00000337386.5	+	4	969	c.508G>A	c.(508-510)Gag>Aag	p.E170K	NAB1_ENST00000409581.1_Missense_Mutation_p.E170K|NAB1_ENST00000409641.1_Missense_Mutation_p.E170K|NAB1_ENST00000357215.5_Missense_Mutation_p.E170K	NM_005966.3	NP_005957.2	Q13506	NAB1_HUMAN	NGFI-A binding protein 1 (EGR1 binding protein 1)	170					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				kidney(2)|large_intestine(2)|lung(1)|prostate(1)|skin(1)	7			OV - Ovarian serous cystadenocarcinoma(117;0.00318)|Epithelial(96;0.0405)|all cancers(119;0.109)			CACTGAGAGCGAGCACAGCCT	0.627000													12	32					0	0	0.000978	0	0
NCOR1	9611	broad.mit.edu	37	17	15968986	15968986	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr17:15968986C>G	ENST00000268712.3	-	33	5021	c.4764G>C	c.(4762-4764)caG>caC	p.Q1588H	NCOR1_ENST00000395857.3_Missense_Mutation_p.Q172H|NCOR1_ENST00000395851.1_Missense_Mutation_p.Q1604H	NM_006311.3	NP_006302.2	O75376	NCOR1_HUMAN	nuclear receptor corepressor 1	1588	Interaction with C1D (By similarity).|Interaction with ETO.				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(26)|ovary(1)|prostate(7)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(10)	107				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		AAAGCTGTCTCTGAAACAGGT	0.423000													10	54					0	0	0.006214	0	0
C3orf70	285382	broad.mit.edu	37	3	184801134	184801134	+	Nonsense_Mutation	SNP	A	A	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr3:184801134A>T	ENST00000335012.2	-	2	604	c.414T>A	c.(412-414)tgT>tgA	p.C138*		NM_001025266.1	NP_001020437.1	A6NLC5	CC070_HUMAN	chromosome 3 open reading frame 70	138										breast(2)|cervix(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|urinary_tract(1)	13						TCCCATTAATACATTTAACCT	0.448000													16	107					0	0	0.003163	0	0
CLVS2	134829	broad.mit.edu	37	6	123319097	123319097	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr6:123319097C>T	ENST00000275162.5	+	2	1510	c.175C>T	c.(175-177)Cgg>Tgg	p.R59W	CLVS2_ENST00000368438.1_Intron	NM_001010852.3	NP_001010852.2	Q5SYC1	CLVS2_HUMAN	clavesin 2						lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(24)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)	40						ACGCTTCTTGCGGGCTAGGAA	0.547000													5	160					0	0	0.000602	0	0
KHNYN	23351	broad.mit.edu	37	14	24906368	24906368	+	Silent	SNP	C	C	G			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr14:24906368C>G	ENST00000251343.5	+	8	2053	c.1914C>G	c.(1912-1914)ctC>ctG	p.L638L	KHNYN_ENST00000556842.1_Silent_p.L638L|KHNYN_ENST00000554268.1_Silent_p.L83L|KHNYN_ENST00000553935.1_Silent_p.L638L			O15037	KHNYN_HUMAN	KH and NYN domain containing	638										kidney(1)|large_intestine(3)|liver(1)|lung(12)|ovary(3)|pancreas(1)|prostate(3)	24						CAGAGCGGCTCCGGCGGCAGC	0.567000											OREG0022628	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	149					0	0	0.004990	0	0
PHKA2	5256	broad.mit.edu	37	X	18936890	18936890	+	Silent	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chrX:18936890C>T	ENST00000379942.4	-	19	2711	c.2046G>A	c.(2044-2046)aaG>aaA	p.K682K		NM_000292.2	NP_000283.1	P46019	KPB2_HUMAN	phosphorylase kinase, alpha 2 (liver)	682					glucose metabolic process|glycogen catabolic process	cytosol|phosphorylase kinase complex|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			NS(1)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(12)|lung(23)|ovary(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	61	Hepatocellular(33;0.183)					CTTCTGTGTTCTTACAAAGAG	0.448000													25	59					0	0	0.003954	0	0
ZNF283	284349	broad.mit.edu	37	19	44351804	44351804	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr19:44351804G>C	ENST00000324461.7	+	7	1348	c.1051G>C	c.(1051-1053)Gaa>Caa	p.E351Q	ZNF283_ENST00000588797.1_Missense_Mutation_p.E212Q	NM_181845.1	NP_862828.1	Q8N7M2	ZN283_HUMAN	zinc finger protein 283	351					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(3)|lung(4)	8		Prostate(69;0.0352)				TAAATGTAAAGAATGTGGGAA	0.378000													16	129					0	0	0.004007	0	0
NAB1	4664	broad.mit.edu	37	2	191524203	191524203	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr2:191524203G>C	ENST00000337386.5	+	4	762	c.301G>C	c.(301-303)Gag>Cag	p.E101Q	NAB1_ENST00000409581.1_Missense_Mutation_p.E101Q|NAB1_ENST00000409641.1_Missense_Mutation_p.E101Q|NAB1_ENST00000357215.5_Missense_Mutation_p.E101Q	NM_005966.3	NP_005957.2	Q13506	NAB1_HUMAN	NGFI-A binding protein 1 (EGR1 binding protein 1)	101					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				kidney(2)|large_intestine(2)|lung(1)|prostate(1)|skin(1)	7			OV - Ovarian serous cystadenocarcinoma(117;0.00318)|Epithelial(96;0.0405)|all cancers(119;0.109)			TAAATTACCAGAGGGATCACC	0.483000													15	54					0	0	0.006122	0	0
PRMT8	56341	broad.mit.edu	37	12	3649787	3649787	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr12:3649787T>C	ENST00000382622.3	+	2	481	c.91T>C	c.(91-93)Tcc>Ccc	p.S31P	PRMT8_ENST00000261252.4_3'UTR|PRMT8_ENST00000452611.2_Missense_Mutation_p.S22P	NM_019854.4	NP_062828.3	Q9NR22	ANM8_HUMAN	protein arginine methyltransferase 8	31					regulation of protein binding	cytoplasm|plasma membrane	histone-arginine N-methyltransferase activity|protein heterodimerization activity|protein homodimerization activity|protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(9)|lung(14)|ovary(3)|skin(5)|upper_aerodigestive_tract(1)	37			OV - Ovarian serous cystadenocarcinoma(31;0.0109)|COAD - Colon adenocarcinoma(12;0.0264)			CAGCCCCCCCTCCCAGCCCCC	0.652000													10	163					0	0	0.001523	0	0
MMP24	10893	broad.mit.edu	37	20	33842328	33842328	+	Silent	SNP	G	G	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr20:33842328G>A	ENST00000246186.6	+	4	673	c.588G>A	c.(586-588)caG>caA	p.Q196Q	EDEM2_ENST00000540582.1_Intron|MMP24-AS1_ENST00000454184.1_RNA|MMP24-AS1_ENST00000456350.1_RNA|MMP24-AS1_ENST00000566203.2_RNA|MMP24-AS1_ENST00000438751.1_RNA|MMP24-AS1_ENST00000433764.1_RNA	NM_006690.3	NP_006681.1	Q9Y5R2	MMP24_HUMAN	matrix metallopeptidase 24 (membrane-inserted)	196					proteolysis	integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			NS(1)|endometrium(3)|large_intestine(1)|lung(2)|prostate(2)|skin(5)	14			BRCA - Breast invasive adenocarcinoma(18;0.00252)			ATGTGTGGCAGAAGGTGACCC	0.493000													145	302					0	0	0.003610	0	0
PPP2R5D	5528	broad.mit.edu	37	6	42978997	42978997	+	Silent	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr6:42978997C>T	ENST00000485511.1	+	16	1961	c.1782C>T	c.(1780-1782)ttC>ttT	p.F594F	PPP2R5D_ENST00000472118.1_Silent_p.F586F|PPP2R5D_ENST00000394110.3_Silent_p.F562F|PPP2R5D_ENST00000461010.1_Silent_p.F488F	NM_001270476.1|NM_006245.3	NP_001257405.1|NP_006236.1	Q14738	2A5D_HUMAN	protein phosphatase 2, regulatory subunit B', delta	594					nervous system development|signal transduction	cytoplasm|nucleus|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	25			Colorectal(64;0.00237)|all cancers(41;0.00411)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0664)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			CGGAAGAGTTCCTAACTGCCA	0.617000													8	83					0	0	0.006214	0	0
RHOB	388	broad.mit.edu	37	2	20647740	20647740	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr2:20647740G>A	ENST00000272233.4	+	1	906	c.514G>A	c.(514-516)Gag>Aag	p.E172K		NM_004040.2	NP_004031.1	P62745	RHOB_HUMAN	ras homolog family member B	172					angiogenesis|axon guidance|cell adhesion|endosome to lysosome transport|negative regulation of cell cycle|platelet activation|positive regulation of angiogenesis|protein transport|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|transformed cell apoptosis	cytosol|late endosome membrane|nucleus|plasma membrane	GTP binding|GTPase activity|protein binding			breast(1)|kidney(1)|lung(2)|ovary(1)|urinary_tract(2)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)	all_epithelial(98;4.19e-09)|Lung NSC(108;0.00452)|Ovarian(717;0.0164)		OV - Ovarian serous cystadenocarcinoma(76;1.14e-22)|Epithelial(75;7.84e-19)		CGAGGTCTTCGAGACGGCCAC	0.687000													29	163					0	0	0.001786	0	0
SMG1	23049	broad.mit.edu	37	16	18850010	18850010	+	Splice_Site	SNP	G	G	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr16:18850010G>C	ENST00000446231.2	-	43	7359	c.6947C>G	c.(6946-6948)tCt>tGt	p.S2316C	SMG1_ENST00000389467.3_Splice_Site_p.S2316C			Q96Q15	SMG1_HUMAN	SMG1 phosphatidylinositol 3-kinase-related kinase	2316	PI3K/PI4K.				DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(8)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(37)|ovary(1)|skin(1)|stomach(4)|urinary_tract(1)	92						TCTTGCATAAGACTAAAGGAA	0.388000													6	79					0	0	0.001168	0	0
FKRP	79147	broad.mit.edu	37	19	47259707	47259707	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr19:47259707G>A	ENST00000318584.5	+	4	1297	c.1000G>A	c.(1000-1002)Gag>Aag	p.E334K	FKRP_ENST00000600646.1_Intron|FKRP_ENST00000391909.3_Missense_Mutation_p.E334K	NM_001039885.2|NM_024301.4	NP_001034974.1|NP_077277.1	Q9H9S5	FKRP_HUMAN	fukutin related protein	334						extracellular space|Golgi apparatus|rough endoplasmic reticulum|sarcolemma	transferase activity			NS(1)|large_intestine(1)|lung(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	7		all_epithelial(76;5.08e-05)|Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000541)|all cancers(93;0.00128)|Epithelial(262;0.0207)|GBM - Glioblastoma multiforme(486;0.0336)		GGGCGTGCTGGAGGCTGCGGG	0.731000													3	11					0	0	0.000602	0	0
SSUH2	51066	broad.mit.edu	37	3	8675375	8675375	+	Silent	SNP	G	G	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr3:8675375G>A	ENST00000317371.4	-	11	1475	c.250C>T	c.(250-252)Ctg>Ttg	p.L84L	SSUH2_ENST00000415132.1_Silent_p.L84L|SSUH2_ENST00000544814.1_Silent_p.L106L|SSUH2_ENST00000341795.3_Silent_p.L84L					ssu-2 homolog (C. elegans)																		TGCCGCTTCAGCTCCTGGATG	0.672000													12	26					0	0	0.001368	0	0
MX2	4600	broad.mit.edu	37	21	42748911	42748911	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr21:42748911G>A	ENST00000330714.3	+	2	262	c.78G>A	c.(76-78)atG>atA	p.M26I	MX2_ENST00000543692.1_Missense_Mutation_p.M26I	NM_002463.1	NP_002454.1	P20592	MX2_HUMAN	myxovirus (influenza virus) resistance 2 (mouse)	26					response to virus|type I interferon-mediated signaling pathway	cytoplasm|nucleus	GTP binding|GTPase activity			breast(2)|endometrium(3)|large_intestine(6)|lung(12)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	34		Prostate(19;1.57e-07)|all_epithelial(19;0.0222)				AAAAAGAAATGAATTCCTTCC	0.517000													12	163					0	0	0.001368	0	0
CES3	23491	broad.mit.edu	37	16	66998347	66998347	+	Silent	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr16:66998347C>T	ENST00000303334.4	+	5	719	c.648C>T	c.(646-648)ttC>ttT	p.F216F	CES3_ENST00000394037.1_Silent_p.F216F	NM_024922.5	NP_079198.2	Q6UWW8	EST3_HUMAN	carboxylesterase 3	216						endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity	p.F216F(1)		breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(6)|ovary(3)|skin(1)	24		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0488)|Epithelial(162;0.127)		TCGCCCCCTTCGGGGGTGACC	0.577000													15	51					0	0	0.004007	0	0
ERBB2	2064	broad.mit.edu	37	17	37866078	37866078	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr17:37866078C>T	ENST00000406381.2	+	7	1007	c.497C>T	c.(496-498)tCt>tTt	p.S166F	ERBB2_ENST00000541774.1_Missense_Mutation_p.S181F|ERBB2_ENST00000445658.2_Intron|ERBB2_ENST00000578199.1_Missense_Mutation_p.S166F|ERBB2_ENST00000540042.1_Missense_Mutation_p.S166F|ERBB2_ENST00000584601.1_Missense_Mutation_p.S166F|ERBB2_ENST00000269571.5_Missense_Mutation_p.S196F|ERBB2_ENST00000540147.1_Missense_Mutation_p.S166F|ERBB2_ENST00000584450.1_Missense_Mutation_p.S196F	NM_001005862.1	NP_001005862.1	P04626	ERBB2_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2	196					cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			NS(1)|breast(16)|central_nervous_system(17)|endometrium(6)|haematopoietic_and_lymphoid_tissue(8)|kidney(4)|large_intestine(16)|liver(3)|lung(125)|ovary(18)|pancreas(1)|prostate(4)|skin(1)|stomach(14)|upper_aerodigestive_tract(9)|urinary_tract(4)	247	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	CACCCCTGTTCTCCGATGTGT	0.587000		1	"""A, Mis, O"""		"""breast, ovarian, other tumour types, NSCLC, gastric"""					TCGA GBM(5;<1E-08)			16	46					0	0	0.004007	0	0
FLT1	2321	broad.mit.edu	37	13	28913371	28913371	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr13:28913371C>T	ENST00000282397.4	-	17	2673	c.2422G>A	c.(2422-2424)Gag>Aag	p.E808K	FLT1_ENST00000540678.1_Missense_Mutation_p.E26K	NM_002019.4	NP_002010.2	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1	808					cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(8)|kidney(3)|large_intestine(20)|lung(55)|ovary(3)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	115	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	TCACACTGCTCATCCAAAGGA	0.408000													5	62					0	0	0.001168	0	0
KIF16B	55614	broad.mit.edu	37	20	16316645	16316645	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr20:16316645C>T	ENST00000354981.2	-	24	3794	c.3637G>A	c.(3637-3639)Gag>Aag	p.E1213K	KIF16B_ENST00000378003.2_Missense_Mutation_p.E398K|KIF16B_ENST00000355755.3_Intron	NM_001199865.1|NM_024704.4	NP_001186794.1|NP_078980.3	Q96L93	KI16B_HUMAN	kinesin family member 16B	1213	PX.				cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(24)|ovary(1)|prostate(15)|skin(3)|upper_aerodigestive_tract(2)	74						GTCCATGTCTCATCTAGGACA	0.294000													13	116					0	0	0.003163	0	0
FAM179B	23116	broad.mit.edu	37	14	45494995	45494995	+	Nonsense_Mutation	SNP	C	C	G			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr14:45494995C>G	ENST00000361462.2	+	8	3431	c.3248C>G	c.(3247-3249)tCa>tGa	p.S1083*	FAM179B_ENST00000382233.2_3'UTR|FAM179B_ENST00000361577.3_Nonsense_Mutation_p.S1083*|KLHL28_ENST00000553817.1_Intron			Q9Y4F4	F179B_HUMAN	family with sequence similarity 179, member B	1083	Ser-rich.						binding			endometrium(4)|kidney(5)|large_intestine(12)|lung(16)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	45						GGGTCATCATCAAATCCACAG	0.318000													12	90					0	0	0.001368	0	0
SLC24A4	123041	broad.mit.edu	37	14	92958550	92958550	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr14:92958550C>T	ENST00000532405.1	+	16	1908	c.1682C>T	c.(1681-1683)tCc>tTc	p.S561F	SLC24A4_ENST00000531433.1_Missense_Mutation_p.S542F|SLC24A4_ENST00000393265.2_Missense_Mutation_p.S497F|SLC24A4_ENST00000298877.1_Missense_Mutation_p.S544F|SLC24A4_ENST00000351924.5_Missense_Mutation_p.S525F			Q8NFF2	NCKX4_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 4	561						integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(3)|endometrium(2)|kidney(2)|large_intestine(6)|lung(20)|ovary(2)|skin(1)	36		all_cancers(154;0.0347)|all_epithelial(191;0.163)		Colorectal(1;0.00242)|COAD - Colon adenocarcinoma(157;0.047)|Epithelial(152;0.0781)|READ - Rectum adenocarcinoma(1;0.176)|all cancers(159;0.182)		CTGGTCTATTCCGTGGTCCTG	0.512000													12	134					0	0	0.000978	0	0
MTRF1	9617	broad.mit.edu	37	13	41834938	41834938	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr13:41834938C>G	ENST00000379480.4	-	2	206	c.106G>C	c.(106-108)Gat>Cat	p.D36H	MTRF1_ENST00000239852.6_5'UTR|MTRF1_ENST00000379477.1_Missense_Mutation_p.D36H|MTRF1_ENST00000430347.2_Missense_Mutation_p.D49H	NM_004294.2	NP_004285.2	O75570	RF1M_HUMAN	mitochondrial translational release factor 1	36					regulation of translational termination	mitochondrion	translation release factor activity, codon specific			breast(1)|endometrium(4)|large_intestine(3)|lung(6)	14		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)|Ovarian(182;0.125)		OV - Ovarian serous cystadenocarcinoma(117;4.24e-10)|all cancers(112;2.05e-09)|Epithelial(112;2.48e-09)|GBM - Glioblastoma multiforme(144;0.00115)|BRCA - Breast invasive adenocarcinoma(63;0.0721)|KIRC - Kidney renal clear cell carcinoma(186;0.248)		AGCCTTGTATCAAGATGTATC	0.398000													26	115					0	0	0.003330	0	0
MUC5B	727897	broad.mit.edu	37	11	1266085	1266085	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr11:1266085C>G	ENST00000447027.1	+	31	8042	c.7984C>G	c.(7984-7986)Ccc>Gcc	p.P2662A	RP11-532E4.2_ENST00000532061.2_RNA|MUC5B_ENST00000529681.1_Missense_Mutation_p.P2659A			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	2659	11 X approximate tandem repeats, Ser/Thr- rich.|7 X Cys-rich subdomain repeats.|Thr-rich.			Missing (in Ref. 6; AAB61398).	cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding	p.P2638A(1)		cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CACCCACACCCCCACAGTGCT	0.617000													4	91					0	0	0.000248	0	0
DLG1	1739	broad.mit.edu	37	3	196812455	196812455	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr3:196812455G>A	ENST00000346964.2	-	17	2122	c.1933C>T	c.(1933-1935)Cgc>Tgc	p.R645C	DLG1_ENST00000448528.2_Missense_Mutation_p.R645C|DLG1_ENST00000443183.1_Missense_Mutation_p.R529C|DLG1_ENST00000452595.1_Missense_Mutation_p.R529C|DLG1_ENST00000314062.3_Missense_Mutation_p.R594C|DLG1_ENST00000422288.1_Missense_Mutation_p.R594C|DLG1_ENST00000450955.1_Missense_Mutation_p.R612C|DLG1_ENST00000392382.2_Missense_Mutation_p.R612C|DLG1_ENST00000357674.4_Missense_Mutation_p.R612C|DLG1_ENST00000419354.1_Missense_Mutation_p.R645C	NM_004087.2	NP_004078.2	Q12959	DLG1_HUMAN	discs, large homolog 1 (Drosophila)	645	SH3.				actin filament organization|axon guidance|cell-cell adhesion|cortical actin cytoskeleton organization|endothelial cell proliferation|establishment or maintenance of cell polarity|interspecies interaction between organisms|mitotic cell cycle G1/S transition checkpoint|negative regulation of mitotic cell cycle|protein localization in plasma membrane|synaptic transmission|tight junction assembly	basolateral plasma membrane|cytosol|endoplasmic reticulum membrane|immunological synapse|MPP7-DLG1-LIN7 complex|nucleus|postsynaptic density|postsynaptic membrane|sarcolemma|tight junction	cytoskeletal protein binding|guanylate kinase activity|L27 domain binding|phosphatase binding|phosphoprotein phosphatase activity|potassium channel regulator activity|protein binding|protein C-terminus binding|protein kinase binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|liver(1)|lung(9)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	26	all_cancers(143;6.22e-10)|Ovarian(172;0.0418)|Breast(254;0.0589)	Lung NSC(153;0.133)	Epithelial(36;3.23e-24)|all cancers(36;2.15e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.0148)		GCATACCTGCGTTTACTGGGA	0.408000													31	165					0	0	0.002836	0	0
TMEM175	84286	broad.mit.edu	37	4	941638	941638	+	Silent	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr4:941638C>T	ENST00000264771.4	+	2	296	c.111C>T	c.(109-111)ctC>ctT	p.L37L	TMEM175_ENST00000508204.1_Intron|TMEM175_ENST00000515740.1_Intron	NM_032326.2	NP_115702.1	Q9BSA9	TM175_HUMAN	transmembrane protein 175	37						integral to membrane				NS(1)|endometrium(1)|large_intestine(2)|lung(6)|pancreas(1)|upper_aerodigestive_tract(3)	14			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			AACGCATGCTCAGCTTCAGTG	0.682000													11	84					0	0	0.000978	0	0
ARHGEF16	27237	broad.mit.edu	37	1	3390080	3390080	+	Silent	SNP	G	G	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr1:3390080G>A	ENST00000378378.4	+	8	1704	c.1299G>A	c.(1297-1299)ctG>ctA	p.L433L	ARHGEF16_ENST00000413250.2_Silent_p.L137L|ARHGEF16_ENST00000378373.1_Silent_p.L145L|ARHGEF16_ENST00000378371.2_Silent_p.L145L	NM_014448.3	NP_055263.2	Q5VV41	ARHGG_HUMAN	Rho guanine nucleotide exchange factor (GEF) 16	433	DH.|Required for RHOG activation and mediates interaction with EPHA2.				activation of Cdc42 GTPase activity|activation of Rac GTPase activity|apoptosis|cell chemotaxis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of establishment of protein localization in plasma membrane|small GTPase mediated signal transduction	cytosol	PDZ domain binding|receptor tyrosine kinase binding|Rho GTPase binding|Rho guanyl-nucleotide exchange factor activity			lung(6)|ovary(1)	7	all_cancers(77;0.00276)|all_epithelial(69;0.00102)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.101)	all_epithelial(116;7.14e-21)|all_lung(118;2.24e-08)|Lung NSC(185;3.55e-06)|Breast(487;0.000765)|Renal(390;0.00121)|Hepatocellular(190;0.0046)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.211)		Epithelial(90;8.62e-38)|OV - Ovarian serous cystadenocarcinoma(86;3.62e-22)|GBM - Glioblastoma multiforme(42;2.49e-12)|Colorectal(212;4.25e-05)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(365;0.000681)|KIRC - Kidney renal clear cell carcinoma(229;0.00549)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.201)		TGCCCCTCCTGATGGATGTAA	0.677000													22	86					0	0	0.003330	0	0
ANKRD20A8P	729171	broad.mit.edu	37	2	95522786	95522786	+	RNA	SNP	T	T	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr2:95522786T>C	ENST00000432432.2	-	0	241					NR_040113.1													p.K44K(1)									CGGCGTCGCCTTTGACAGCTG	0.687000													7	109					0	0	0.008291	0	0
FLG2	388698	broad.mit.edu	37	1	152326888	152326888	+	Missense_Mutation	SNP	G	G	C	rs112104081		TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr1:152326888G>C	ENST00000388718.5	-	3	3446	c.3374C>G	c.(3373-3375)tCt>tGt	p.S1125C	FLG-AS1_ENST00000445097.1_RNA|FLG-AS1_ENST00000392688.2_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	1125	Ser-rich.						calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AAAGCCAGAAGACTGACCTGA	0.512000													71	469					0	0	0.003610	0	0
KIAA1524	57650	broad.mit.edu	37	3	108295194	108295194	+	Splice_Site	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr3:108295194C>T	ENST00000295746.8	-	8	895		c.e8-1		KIAA1524_ENST00000487834.1_Splice_Site|KIAA1524_ENST00000491772.1_Splice_Site	NM_020890.2	NP_065941.2	Q8TCG1	CIP2A_HUMAN	KIAA1524							cytoplasm|integral to membrane	protein binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(21)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						GTGCTCATATCTAGGTTTAGA	0.264000													12	102					0	0	0.001855	0	0
FAT4	79633	broad.mit.edu	37	4	126238718	126238718	+	Silent	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr4:126238718C>T	ENST00000394329.3	+	1	1165	c.1152C>T	c.(1150-1152)gaC>gaT	p.D384D		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	384	Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						CCGTGACGGACGCAGATTCTC	0.597000											OREG0016317	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	42					0	0	0.001984	0	0
ERBB3	2065	broad.mit.edu	37	12	56492623	56492623	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr12:56492623G>C	ENST00000267101.3	+	23	3213	c.2773G>C	c.(2773-2775)Gag>Cag	p.E925Q	ERBB3_ENST00000450146.2_Missense_Mutation_p.E282Q|ERBB3_ENST00000553131.1_Missense_Mutation_p.E166Q|ERBB3_ENST00000549832.1_Missense_Mutation_p.E45Q|ERBB3_ENST00000415288.2_Missense_Mutation_p.E866Q	NM_001982.3	NP_001973.2	P21860	ERBB3_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3	925	Protein kinase.				cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(2)|lung(3)|ovary(1)|skin(1)|stomach(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			AGACCTGCTAGAGAAGGGGGA	0.527000													22	111					0	0	0.001882	0	0
TTN	7273	broad.mit.edu	37	2	179449901	179449901	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr2:179449901G>C	ENST00000589042.1	-	309	64794	c.64570C>G	c.(64570-64572)Ctg>Gtg	p.L21524V	TTN_ENST00000359218.5_Missense_Mutation_p.L12584V|TTN_ENST00000460472.2_Missense_Mutation_p.L12459V|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.L12651V|TTN_ENST00000591111.1_Missense_Mutation_p.L19883V|TTN_ENST00000342992.6_Missense_Mutation_p.L18956V|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000590743.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000590807.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	19883	Fibronectin type-III 56.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTATGATCAGAATTGAAGAG	0.433000													17	340					0	0	0.004007	0	0
WARS2	10352	broad.mit.edu	37	1	119619202	119619202	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr1:119619202C>T	ENST00000369426.5	-	2	122	c.119G>A	c.(118-120)gGc>gAc	p.G40D	WARS2_ENST00000537870.1_5'UTR|WARS2_ENST00000235521.4_Missense_Mutation_p.G40D			Q9UGM6	SYWM_HUMAN	tryptophanyl tRNA synthetase 2, mitochondrial	40					tryptophanyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|tryptophan-tRNA ligase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(7)|prostate(2)	15	all_neural(166;0.187)	all_lung(203;2.48e-06)|Lung NSC(69;1.74e-05)|all_epithelial(167;0.000564)		Lung(183;0.0629)	L-Tryptophan(DB00150)	AGGTTGAATGCCGGAAAATAC	0.433000													5	282					0	0	0.001168	0	0
NUTM1	256646	broad.mit.edu	37	15	34648835	34648835	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr15:34648835G>A	ENST00000537011.1	+	8	3008	c.2626G>A	c.(2626-2628)Gat>Aat	p.D876N	NUTM1_ENST00000333756.4_Missense_Mutation_p.D848N|NUTM1_ENST00000438749.3_Missense_Mutation_p.D866N	NM_001284292.1	NP_001271221.1			NUT midline carcinoma, family member 1																		AGAAAGTGGTGATTCCACACT	0.517000													17	67					0	0	0.006122	0	0
TBP	6908	broad.mit.edu	37	6	170871046	170871046	+	Silent	SNP	A	A	G	rs10592951		TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr6:170871046A>G	ENST00000392092.2	+	3	501	c.222A>G	c.(220-222)caA>caG	p.Q74Q	TBP_ENST00000540980.1_Silent_p.Q54Q|TBP_ENST00000230354.6_Silent_p.Q74Q	NM_003194.4	NP_003185.1	P20226	TBP_HUMAN	TATA box binding protein	74	Poly-Gln.				cell death|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|viral reproduction	transcription factor TFIIA complex|transcription factor TFIID complex	repressing transcription factor binding|transcription regulatory region DNA binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(1)	26		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;1.07e-22)|BRCA - Breast invasive adenocarcinoma(81;5.01e-06)|GBM - Glioblastoma multiforme(31;0.00591)		agcaacagcaacagcagcagc	0.567000													5	100					0	0	0.004482	0	0
HTRA2	27429	broad.mit.edu	37	2	74757813	74757813	+	Silent	SNP	C	C	G			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr2:74757813C>G	ENST00000258080.3	+	2	1206	c.576C>G	c.(574-576)ctC>ctG	p.L192L	HTRA2_ENST00000467961.1_3'UTR|HTRA2_ENST00000352222.3_Silent_p.L192L	NM_013247.4	NP_037379.1	O43464	HTRA2_HUMAN	HtrA serine peptidase 2	192	Serine protease.				apoptosis|proteolysis|response to stress	CD40 receptor complex|endoplasmic reticulum membrane|internal side of plasma membrane|mitochondrial intermembrane space|mitochondrial membrane|nucleus	serine-type endopeptidase activity|unfolded protein binding			endometrium(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	12						CCGATGGGCTCATTGTCACCA	0.597000													14	83					0	0	0.001855	0	0
GATA2	2624	broad.mit.edu	37	3	128200071	128200071	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr3:128200071C>G	ENST00000341105.2	-	6	1565	c.1234G>C	c.(1234-1236)Gag>Cag	p.E412Q	GATA2_ENST00000430265.2_Missense_Mutation_p.E398Q|GATA2_ENST00000489987.1_5'UTR|GATA2_ENST00000487848.1_Missense_Mutation_p.E412Q	NM_032638.4	NP_116027.2	P23769	GATA2_HUMAN	GATA binding protein 2	412					blood coagulation|negative regulation of fat cell differentiation|negative regulation of fat cell proliferation|negative regulation of neural precursor cell proliferation|negative regulation of Notch signaling pathway|phagocytosis|positive regulation of angiogenesis|positive regulation of phagocytosis|positive regulation of transcription from RNA polymerase II promoter	nucleoplasm	C2H2 zinc finger domain binding|chromatin binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(58)|kidney(2)|large_intestine(3)|lung(9)|prostate(3)|skin(1)|urinary_tract(1)	79				GBM - Glioblastoma multiforme(114;0.173)		TCGAAGCACTCCGCCCCTTTC	0.572000			Mis		AML(CML blast transformation)								23	105					0	0	0.001882	0	0
MYH9	4627	broad.mit.edu	37	22	36700135	36700135	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr22:36700135C>T	ENST00000216181.5	-	19	2526	c.2296G>A	c.(2296-2298)Ggt>Agt	p.G766S		NM_002473.4	NP_002464.1	P35579	MYH9_HUMAN	myosin, heavy chain 9, non-muscle	766	Myosin head-like.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			NS(1)|breast(8)|central_nervous_system(3)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(16)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(3)	86						GCCAGCACACCGGCACGGAAG	0.597000			T	ALK	ALCL		"""Deafness, autosomal dominant 17, Epstein syndrome, Fechtner syndrome, May-Hegglin anomaly, Sebastian syndrome"""		Hereditary Macrothrombocytopenia, MYH9-associated				15	65					0	0	0.003163	0	0
SLC6A4	6532	broad.mit.edu	37	17	28537652	28537652	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr17:28537652C>G	ENST00000401766.2	-	10	1842	c.1330G>C	c.(1330-1332)Gag>Cag	p.E444Q	SLC6A4_ENST00000261707.3_Missense_Mutation_p.E444Q			P31645	SC6A4_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 4	444					response to toxin|serotonin uptake|thalamus development	cytosol|endomembrane system|endosome membrane|membrane raft	actin filament binding|Rab GTPase binding|serotonin transmembrane transporter activity|serotonin:sodium symporter activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(4)	25					Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Citalopram(DB00215)|Clomipramine(DB01242)|Cocaine(DB00907)|Desipramine(DB01151)|Dexfenfluramine(DB01191)|Dextromethorphan(DB00514)|Doxepin(DB01142)|Duloxetine(DB00476)|Escitalopram(DB01175)|Fluoxetine(DB00472)|Fluvoxamine(DB00176)|Imipramine(DB00458)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Minaprine(DB00805)|Nefazodone(DB01149)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phentermine(DB00191)|Protriptyline(DB00344)|Sertraline(DB01104)|Sibutramine(DB01105)|Tegaserod(DB01079)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)|Zimelidine(DB04832)	ATCACCCCCTCCAAGCCTGCA	0.602000													17	125					0	0	0.008871	0	0
GBP4	115361	broad.mit.edu	37	1	89654439	89654439	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr1:89654439C>G	ENST00000355754.6	-	8	1333	c.1236G>C	c.(1234-1236)caG>caC	p.Q412H		NM_052941.4	NP_443173.2	Q96PP9	GBP4_HUMAN	guanylate binding protein 4	412						cytoplasm	GTP binding|GTPase activity			central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(19)|skin(1)|stomach(2)|urinary_tract(1)	33				all cancers(265;0.00723)|Epithelial(280;0.0291)		CCTCTTCATTCTGCAGCACAA	0.448000													30	312					0	0	0.002445	0	0
U2AF2	11338	broad.mit.edu	37	19	56171880	56171880	+	Splice_Site	SNP	A	A	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr19:56171880A>C	ENST00000450554.2	+	4	1189		c.e4-1		U2AF2_ENST00000308924.4_Splice_Site	NM_001012478.1|NM_007279.2	NP_001012496.1|NP_009210.1	P26368	U2AF2_HUMAN	U2 small nuclear RNA auxiliary factor 2						mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	nucleoplasm|spliceosomal complex	enzyme binding|nucleotide binding|RNA binding	p.?(2)		biliary_tract(1)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|urinary_tract(2)	21		Colorectal(82;0.00244)|Ovarian(87;0.133)	BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.107)		CACCTCCCCCAGTCGTTCCCC	0.637000													5	26					0	0	0.000978	0	0
METTL13	51603	broad.mit.edu	37	1	171759640	171759640	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr1:171759640C>T	ENST00000361735.3	+	5	1624	c.1358C>T	c.(1357-1359)gCg>gTg	p.A453V	METTL13_ENST00000362019.3_Missense_Mutation_p.A367V|METTL13_ENST00000458517.1_Missense_Mutation_p.A452V|METTL13_ENST00000367737.5_Missense_Mutation_p.A297V|METTL13_ENST00000466643.1_Intron	NM_015935.4	NP_057019.3	Q8N6R0	MTL13_HUMAN	methyltransferase like 13	453							methyltransferase activity|protein binding			breast(3)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(8)|lung(17)|stomach(3)	41						CCTGCTGATGCGGAGGACCTC	0.532000													22	113					0	0	0.001523	0	0
NCKAP1	10787	broad.mit.edu	37	2	183822295	183822295	+	Silent	SNP	G	G	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr2:183822295G>A	ENST00000361354.4	-	19	2283	c.1911C>T	c.(1909-1911)atC>atT	p.I637I	NCKAP1_ENST00000360982.2_Silent_p.I643I	NM_013436.3	NP_038464.1	Q9Y2A7	NCKP1_HUMAN	NCK-associated protein 1						apoptosis|central nervous system development	integral to membrane|lamellipodium membrane	protein binding			breast(3)|cervix(2)|endometrium(3)|kidney(4)|large_intestine(11)|lung(16)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	45			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			CTGCTTGACTGATAGTTTTGG	0.378000													24	117					0	0	0.003330	0	0
NTRK1	4914	broad.mit.edu	37	1	156851342	156851342	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr1:156851342G>A	ENST00000368196.3	+	16	2401	c.2281G>A	c.(2281-2283)Gag>Aag	p.E761K	NTRK1_ENST00000358660.3_Missense_Mutation_p.E764K|NTRK1_ENST00000392302.2_Missense_Mutation_p.E731K|NTRK1_ENST00000531606.1_3'UTR|NTRK1_ENST00000524377.1_Missense_Mutation_p.E767K	NM_001012331.1	NP_001012331.1	P04629	NTRK1_HUMAN	neurotrophic tyrosine kinase, receptor, type 1	767	Protein kinase.				activation of adenylate cyclase activity|activation of MAPKK activity|activation of phospholipase C activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(35)|ovary(8)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	74	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)				Imatinib(DB00619)	CTGGCAGCGGGAGCCCCAGCA	0.682000			T	"""TPM3, TPR, TFG"""	papillary thyroid					TSP Lung(10;0.080)			5	22					0	0	0.000602	0	0
GGT3P	2679	broad.mit.edu	37	22	18769145	18769145	+	RNA	SNP	G	G	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr22:18769145G>A	ENST00000412448.1	-	0	1141																											TGAGGCTGCCGTTGTAGAAGG	0.612000													3	16					0	0	0.004672	0	0
CAPN1	823	broad.mit.edu	37	11	64977530	64977530	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr11:64977530G>C	ENST00000527323.1	+	18	2145	c.1905G>C	c.(1903-1905)atG>atC	p.M635I	CAPN1_ENST00000524773.1_Missense_Mutation_p.M635I|CAPN1_ENST00000279247.6_Missense_Mutation_p.M635I|CAPN1_ENST00000533129.1_Missense_Mutation_p.M635I|CAPN1_ENST00000533820.1_Missense_Mutation_p.M635I			P07384	CAN1_HUMAN	calpain 1, (mu/I) large subunit	635	Domain IV.|EF-hand 3.				positive regulation of cell proliferation|proteolysis	cytoplasm|plasma membrane	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|protein binding			breast(2)|endometrium(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|skin(1)	13		Lung NSC(402;0.094)|Melanoma(852;0.16)		Lung(977;0.00168)|LUSC - Lung squamous cell carcinoma(976;0.00813)		CGGGCAGCATGAGTGCCTACG	0.642000													14	80					0	0	0.002450	0	0
TIE1	7075	broad.mit.edu	37	1	43788382	43788382	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr1:43788382G>A	ENST00000372476.3	+	23	3485	c.3406G>A	c.(3406-3408)Gag>Aag	p.E1136K	TIE1_ENST00000433781.2_Missense_Mutation_p.E781K	NM_001253357.1|NM_005424.4	NP_001240286.1|NP_005415.1	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	1136					mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(8)|lung(28)|ovary(3)|prostate(2)|salivary_gland(1)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	70	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TGCCACAGCTGAGGAGGCCTG	0.577000													6	37					0	0	0.001168	0	0
RAB3D	9545	broad.mit.edu	37	19	11447899	11447899	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr19:11447899G>C	ENST00000222120.3	-	2	437	c.177C>G	c.(175-177)ttC>ttG	p.F59L	RAB3D_ENST00000589655.1_Missense_Mutation_p.F59L	NM_004283.3	NP_004274.1	O95716	RAB3D_HUMAN	RAB3D, member RAS oncogene family	59					exocytosis|protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			cervix(1)|endometrium(3)|kidney(1)|large_intestine(3)|liver(1)|lung(3)|ovary(2)	14						TCTTGACCTTGAAATCGATGC	0.572000													49	332					0	0	0.003610	0	0
PTPLAD1	51495	broad.mit.edu	37	15	65849119	65849119	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr15:65849119C>T	ENST00000261875.5	+	4	413	c.247C>T	c.(247-249)Cag>Tag	p.Q83*	PTPLAD1_ENST00000562901.1_5'UTR|PTPLAD1_ENST00000442729.2_Intron|PTPLAD1_ENST00000568793.1_Nonsense_Mutation_p.Q58*|PTPLAD1_ENST00000566511.1_5'UTR|PTPLAD1_ENST00000566074.1_5'UTR|PTPLAD1_ENST00000569894.1_5'UTR|PTPLAD1_ENST00000565299.1_Nonsense_Mutation_p.Q121*	NM_016395.2	NP_057479.2	Q9P035	HACD3_HUMAN	protein tyrosine phosphatase-like A domain containing 1	83	CS.				activation of JUN kinase activity|fatty acid biosynthetic process|I-kappaB kinase/NF-kappaB cascade|Rac protein signal transduction	endoplasmic reticulum membrane|integral to membrane	GTPase activator activity|lyase activity|protein binding			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(1)|pancreas(1)	5						CATTACAGTACAGAAGAAAGT	0.468000													8	20					0	0	0.003080	0	0
CNNM4	26504	broad.mit.edu	37	2	97427798	97427798	+	Silent	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr2:97427798C>T	ENST00000377075.2	+	1	1160	c.1062C>T	c.(1060-1062)ctC>ctT	p.L354L		NM_020184.3	NP_064569.3	Q6P4Q7	CNNM4_HUMAN	cyclin M4	354	DUF21.				biomineral tissue development|ion transport|response to stimulus|visual perception	integral to membrane|plasma membrane				breast(2)|endometrium(4)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)	20						ATAATGACCTCGTGAAAGAGG	0.512000													19	105					0	0	0.007413	0	0
EEF1A2	1917	broad.mit.edu	37	20	62129078	62129078	+	Silent	SNP	G	G	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr20:62129078G>A	ENST00000217182.3	-	2	204	c.39C>T	c.(37-39)atC>atT	p.I13I	EEF1A2_ENST00000298049.7_Silent_p.I13I	NM_001958.3	NP_001949.1	Q05639	EF1A2_HUMAN	eukaryotic translation elongation factor 1 alpha 2	13						nucleus	GTP binding|GTPase activity|protein binding|translation elongation factor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(14)|stomach(1)	20	all_cancers(38;9.45e-12)		BRCA - Breast invasive adenocarcinoma(10;1.22e-05)			CCACGTGGCCGATGACCACGA	0.602000													22	192					0	0	0.001882	0	0
MEA1	4201	broad.mit.edu	37	6	42980214	42980214	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr6:42980214C>T	ENST00000244711.3	-	4	706	c.552G>A	c.(550-552)tgG>tgA	p.W184*		NM_014623.2	NP_055438.1	Q16626	MEA1_HUMAN	male-enhanced antigen 1	184					cell differentiation|male gonad development|spermatogenesis		protein binding			central_nervous_system(1)|large_intestine(3)|lung(1)|skin(1)	6			Colorectal(64;0.00237)|all cancers(41;0.00411)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0664)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			GTGGTCACTTCCAGGCAGGGG	0.567000													24	352					0	0	0.002780	0	0
PPP2R5D	5528	broad.mit.edu	37	6	42974683	42974683	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr6:42974683C>G	ENST00000485511.1	+	4	536	c.357C>G	c.(355-357)atC>atG	p.I119M	PPP2R5D_ENST00000472118.1_Missense_Mutation_p.I111M|PPP2R5D_ENST00000394110.3_Missense_Mutation_p.I87M|PPP2R5D_ENST00000461010.1_Missense_Mutation_p.I13M	NM_001270476.1|NM_006245.3	NP_001257405.1|NP_006236.1	Q14738	2A5D_HUMAN	protein phosphatase 2, regulatory subunit B', delta	119					nervous system development|signal transduction	cytoplasm|nucleus|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	25			Colorectal(64;0.00237)|all cancers(41;0.00411)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0664)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			AGCTGTTTATCCAGAAGCTAC	0.567000													25	251					0	0	0.003954	0	0
PTER	9317	broad.mit.edu	37	10	16547137	16547137	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr10:16547137G>A	ENST00000378000.1	+	5	1063	c.817G>A	c.(817-819)Gat>Aat	p.D273N	PTER_ENST00000423462.2_Intron|PTER_ENST00000298942.3_Missense_Mutation_p.D273N|PTER_ENST00000535784.2_Missense_Mutation_p.D273N	NM_001001484.2|NM_001261838.1|NM_030664.4	NP_001001484.1|NP_001248767.1|NP_109589.2	Q96BW5	PTER_HUMAN	phosphotriesterase related	273					catabolic process		hydrolase activity, acting on ester bonds|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(7)|lung(4)|ovary(2)	15						TGACATGCCTGATGATAACAA	0.398000													22	151					0	0	0.003954	0	0
ZBTB20	26137	broad.mit.edu	37	3	114057927	114057927	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr3:114057927G>C	ENST00000462705.1	-	12	2753	c.1932C>G	c.(1930-1932)tgC>tgG	p.C644W	ZBTB20_ENST00000357258.3_Missense_Mutation_p.C644W|ZBTB20_ENST00000474710.1_Missense_Mutation_p.C717W|ZBTB20_ENST00000464560.1_Missense_Mutation_p.C644W|ZBTB20_ENST00000393785.2_Missense_Mutation_p.C644W|ZBTB20_ENST00000471418.1_Missense_Mutation_p.C644W|ZBTB20_ENST00000481632.1_Missense_Mutation_p.C644W	NM_001164343.1	NP_001157815.1	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20	717					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(8)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	48				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)		GGCAGACGGAGCAGACGTAAG	0.587000													18	100					0	0	0.007413	0	0
CD82	3732	broad.mit.edu	37	11	44616272	44616272	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr11:44616272C>G	ENST00000227155.4	+	3	308	c.60C>G	c.(58-60)ttC>ttG	p.F20L	CD82_ENST00000342935.3_Missense_Mutation_p.F20L	NM_002231.3	NP_002222.1	P27701	CD82_HUMAN	CD82 molecule	20						integral to plasma membrane	protein binding			large_intestine(1)|ovary(1)	2						ACTTGATCTTCTTTGTAAGTA	0.547000													17	95					0	0	0.006122	0	0
LSM12	124801	broad.mit.edu	37	17	42117556	42117556	+	Silent	SNP	G	G	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr17:42117556G>A	ENST00000591247.1	-	4	649	c.327C>T	c.(325-327)gtC>gtT	p.V109V	LSM12_ENST00000293406.3_Silent_p.V109V|LSM12_ENST00000585388.1_Silent_p.V109V	NM_152344.3	NP_689557.1	Q3MHD2	LSM12_HUMAN	LSM12 homolog (S. cerevisiae)	109							protein binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|prostate(1)	6		Breast(137;0.0313)|Prostate(33;0.0861)		BRCA - Breast invasive adenocarcinoma(366;0.115)		CCTCTAGAGAGACACCAGCAC	0.537000													12	46					0	0	0.000978	0	0
C1orf65	164127	broad.mit.edu	37	1	223568356	223568356	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr1:223568356G>C	ENST00000366875.3	+	1	1642	c.1539G>C	c.(1537-1539)aaG>aaC	p.K513N		NM_152610.2	NP_689823.2	Q8N715	CA065_HUMAN	chromosome 1 open reading frame 65	513										breast(4)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(12)|skin(3)	29				GBM - Glioblastoma multiforme(131;0.0704)		CGGATGAGAAGATCCGACAGG	0.582000													20	110					0	0	0.008871	0	0
SGK1	6446	broad.mit.edu	37	6	134492271	134492271	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr6:134492271G>C	ENST00000367858.5	-	12	1810	c.1213C>G	c.(1213-1215)Ctg>Gtg	p.L405V	SGK1_ENST00000528577.1_Missense_Mutation_p.L338V|SGK1_ENST00000367857.5_Missense_Mutation_p.L300V|SGK1_ENST00000413996.3_Missense_Mutation_p.L324V|SGK1_ENST00000237305.7_Missense_Mutation_p.L310V|SGK1_ENST00000475719.2_Missense_Mutation_p.L266V	NM_001143676.1	NP_001137148.1	O00141	SGK1_HUMAN	serum/glucocorticoid regulated kinase 1	310	AGC-kinase C-terminal.				apoptosis|response to stress|sodium ion transport	endoplasmic reticulum|nucleus|plasma membrane	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(21)|kidney(3)|large_intestine(3)|lung(10)|ovary(1)|skin(4)|stomach(1)	46	Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.00317)|GBM - Glioblastoma multiforme(68;0.00847)		GGCTTGTTCAGAATGTTGTCG	0.463000													9	112					0	0	0.008291	0	0
GGNBP2	79893	broad.mit.edu	37	17	34937960	34937960	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr17:34937960C>T	ENST00000304718.4	+	9	1523	c.1207C>T	c.(1207-1209)Caa>Taa	p.Q403*		NM_024835.3	NP_079111.1	Q9H3C7	GGNB2_HUMAN	gametogenetin binding protein 2	403					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasmic membrane-bounded vesicle				breast(1)|endometrium(4)|kidney(3)|large_intestine(7)|liver(1)|lung(14)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|stomach(1)	38		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0193)		GGAAGTAAGCCAAGAGAAGGT	0.398000													13	75					0	0	0.001368	0	0
NAPG	8774	broad.mit.edu	37	18	10539786	10539786	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr18:10539786C>T	ENST00000322897.6	+	6	355	c.286C>T	c.(286-288)Cag>Tag	p.Q96*	NAPG_ENST00000542979.1_Nonsense_Mutation_p.Q14*	NM_003826.2	NP_003817.1	Q99747	SNAG_HUMAN	N-ethylmaleimide-sensitive factor attachment protein, gamma	96					cellular membrane fusion|intra-Golgi vesicle-mediated transport|intracellular protein transport|protein complex assembly|protein stabilization	membrane|membrane fraction|mitochondrion	protein binding			large_intestine(2)|lung(2)	4						AGAGGCCGTTCAGCTAATTGA	0.458000													12	86					0	0	0.001368	0	0
BCAS2	10286	broad.mit.edu	37	1	115118266	115118266	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr1:115118266C>G	ENST00000369541.3	-	4	411	c.364G>C	c.(364-366)Gag>Cag	p.E122Q	BCAS2_ENST00000485021.1_5'UTR	NM_005872.2	NP_005863.1	O75934	SPF27_HUMAN	breast carcinoma amplified sequence 2	122					mRNA processing|RNA splicing, via transesterification reactions	nucleolus|spliceosomal complex	protein binding			biliary_tract(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(4)	13	all_epithelial(7;9.54e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		TCCAGATTCTCAATTCTAACT	0.383000													25	121					0	0	0.003330	0	0
REG1B	5968	broad.mit.edu	37	2	79314684	79314684	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr2:79314684G>C	ENST00000305089.3	-	2	135	c.55C>G	c.(55-57)Ctg>Gtg	p.L19V		NM_006507.3	NP_006498.1	P48304	REG1B_HUMAN	regenerating islet-derived 1 beta	19					cell proliferation	extracellular region	sugar binding			central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(40)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	51						CCTTGGCTCAGAGACAGGAAC	0.473000													10	33					0	0	0.006214	0	0
MAB21L3	126868	broad.mit.edu	37	1	116663613	116663613	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr1:116663613C>A	ENST00000369500.3	+	3	374	c.109C>A	c.(109-111)Cat>Aat	p.H37N		NM_152367.2	NP_689580.2	Q8N8X9	MB213_HUMAN	mab-21-like 3 (C. elegans)	37										breast(2)|endometrium(1)|large_intestine(3)|lung(8)|prostate(2)|skin(2)|urinary_tract(1)	19						AGTCGTTCATCATTTGACCAC	0.468000													33	224					1.62565e-12	3.2078e-12	0.002445	1	0
FASTKD1	79675	broad.mit.edu	37	2	170387907	170387907	+	Nonsense_Mutation	SNP	G	G	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr2:170387907G>C	ENST00000453153.2	-	13	2628	c.2282C>G	c.(2281-2283)tCa>tGa	p.S761*	FASTKD1_ENST00000453929.2_Nonsense_Mutation_p.S718*|FASTKD1_ENST00000495505.1_5'UTR	NM_024622.3	NP_078898.3	Q53R41	FAKD1_HUMAN	FAST kinase domains 1	761					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(5)|large_intestine(10)|lung(9)|ovary(4)|prostate(3)	37						TTCGATATTTGATTCCCAGGG	0.348000													8	54					0	0	0.003080	0	0
C1orf194	127003	broad.mit.edu	37	1	109649635	109649635	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr1:109649635G>T	ENST00000369949.4	-	3	451	c.272C>A	c.(271-273)aCc>aAc	p.T91N	C1orf194_ENST00000369948.3_Missense_Mutation_p.T103N|C1orf194_ENST00000369945.3_Missense_Mutation_p.T64N	NM_001122961.1	NP_001116433.1	Q5T5A4	CA194_HUMAN	chromosome 1 open reading frame 194	103										large_intestine(2)|lung(2)|ovary(2)	6						TTACCTATAGGTATCCTGCGT	0.448000													20	152					2.4624e-09	4.77899e-09	0.008871	1	0
PRKAR2A	5576	broad.mit.edu	37	3	48789650	48789650	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr3:48789650C>G	ENST00000265563.8	-	10	1289	c.1040G>C	c.(1039-1041)aGa>aCa	p.R347T	PRKAR2A_ENST00000296446.8_Missense_Mutation_p.R325T|PRKAR2A_ENST00000454963.1_Missense_Mutation_p.R347T	NM_004157.2	NP_004148.1	P13861	KAP2_HUMAN	protein kinase, cAMP-dependent, regulatory, type II, alpha	347					activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|intracellular signal transduction|nerve growth factor receptor signaling pathway|regulation of insulin secretion|transmembrane transport|water transport	centrosome|cytosol|membrane fraction	cAMP binding|cAMP-dependent protein kinase regulator activity		SLC26A6/PRKAR2A(2)	breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|liver(1)|ovary(1)	6				BRCA - Breast invasive adenocarcinoma(193;0.000176)|Kidney(197;0.00246)|KIRC - Kidney renal clear cell carcinoma(197;0.00261)		TGAGGCAGCTCTGGGTTTGTT	0.428000													11	99					0	0	0.001855	0	0
SLC17A8	246213	broad.mit.edu	37	12	100813592	100813592	+	Splice_Site	SNP	G	G	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr12:100813592G>C	ENST00000323346.5	+	12	1738		c.e12-1		SLC17A8_ENST00000552697.1_Splice_Site|SLC17A8_ENST00000392989.3_Splice_Site	NM_001145288.1|NM_139319.2	NP_001138760.1|NP_647480.1	Q8NDX2	VGLU3_HUMAN	solute carrier family 17 (vesicular glutamate transporter), member 8						neurotransmitter transport|sensory perception of sound|sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(25)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	44						TCCTTATTTAGACCCGTGAAG	0.443000													10	63					0	0	0.006214	0	0
BMS1P20	96610	broad.mit.edu	37	22	22664186	22664186	+	RNA	SNP	A	A	G			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr22:22664186A>G	ENST00000426066.1	+	0	709					NR_027293.1																						CAGATCAAGAAAGCACTCTGA	0.498000													4	170					0	0	0.001168	0	0
PDCL	5082	broad.mit.edu	37	9	125582724	125582724	+	Silent	SNP	G	G	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr9:125582724G>A	ENST00000259467.4	-	4	711	c.546C>T	c.(544-546)gtC>gtT	p.V182V		NM_005388.4	NP_005379.3	Q13371	PHLP_HUMAN	phosducin-like	182					signal transduction|visual perception					endometrium(1)|large_intestine(2)|lung(5)|skin(1)|stomach(1)	10						GAACCATGATGACAATGCTTT	0.468000													22	129					0	0	0.001882	0	0
PNMAL2	57469	broad.mit.edu	37	19	46997203	46997203	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr19:46997203G>A	ENST00000599531.1	-	1	2552	c.1520C>T	c.(1519-1521)tCg>tTg	p.S507L	PNMAL2_ENST00000377655.2_Intron|PNMAL2_ENST00000594749.1_Intron	NM_020709.1	NP_065760.1	Q9ULN7	PNML2_HUMAN	paraneoplastic Ma antigen family-like 2	507										central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(4)	8		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000322)|all cancers(93;0.00233)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		CTGTTCGTCCGAAGCCTCCTC	0.672000													14	114					0	0	0.002450	0	0
NUP155	9631	broad.mit.edu	37	5	37303498	37303498	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr5:37303498C>G	ENST00000231498.3	-	28	3384	c.3181G>C	c.(3181-3183)Gag>Cag	p.E1061Q	NUP155_ENST00000381843.2_Missense_Mutation_p.E1002Q|NUP155_ENST00000513532.1_Missense_Mutation_p.E997Q|NUP155_ENST00000502533.1_5'UTR	NM_153485.1	NP_705618.1	O75694	NU155_HUMAN	nucleoporin 155kDa	1061					carbohydrate metabolic process|glucose transport|mRNA transport|nucleocytoplasmic transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore	protein binding|structural constituent of nuclear pore|transporter activity			endometrium(1)|kidney(16)|large_intestine(5)|lung(29)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	62	all_lung(31;0.000137)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AGATGTGGCTCCAGAAATGGA	0.343000													8	79					0	0	0.003080	0	0
GNAI2	2771	broad.mit.edu	37	3	50295089	50295089	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr3:50295089C>G	ENST00000313601.6	+	8	1419	c.1035C>G	c.(1033-1035)atC>atG	p.I345M	GNAI2_ENST00000491100.1_3'UTR|GNAI2_ENST00000536647.1_Missense_Mutation_p.I264M|GNAI2_ENST00000440628.1_Missense_Mutation_p.I293M|GNAI2_ENST00000266027.5_Missense_Mutation_p.I329M|GNAI2_ENST00000451956.1_Missense_Mutation_p.I308M|GNAI2_ENST00000422163.1_Missense_Mutation_p.I329M	NM_002070.2	NP_002061.1	P04899	GNAI2_HUMAN	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	345					adenosine receptor signaling pathway|cell cycle|cell division|gamma-aminobutyric acid signaling pathway|inhibition of adenylate cyclase activity by G-protein signaling pathway|negative regulation of calcium ion transport via voltage-gated calcium channel activity|platelet activation|response to nutrient|synaptic transmission	centrosome|heterotrimeric G-protein complex|midbody	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|liver(2)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	16				BRCA - Breast invasive adenocarcinoma(193;0.000288)|KIRC - Kidney renal clear cell carcinoma(197;0.00571)|Kidney(197;0.00651)		ATGTCATCATCAAGAACAACC	0.587000													7	76					0	0	0.004482	0	0
CDH13	1012	broad.mit.edu	37	16	83781740	83781740	+	Silent	SNP	T	T	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr16:83781740T>C	ENST00000566620.1	+	11	1856	c.1566T>C	c.(1564-1566)ggT>ggC	p.G522G	RP11-298D21.1_ENST00000563981.1_RNA|CDH13_ENST00000428848.3_Silent_p.G483G|RP11-298D21.1_ENST00000569165.1_RNA|CDH13_ENST00000268613.10_Silent_p.G569G|RP11-298D21.1_ENST00000570056.1_RNA	NM_001220488.1|NM_001220489.1|NM_001220490.1|NM_001257.4	NP_001207417.1|NP_001207418.1|NP_001207419.1|NP_001248.1	P55290	CAD13_HUMAN	cadherin 13	522	Cadherin 4.				adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)		ACCCAGCAGGTTGGCTGAATA	0.468000													35	225					0	0	0.003755	0	0
TSC1	7248	broad.mit.edu	37	9	135776220	135776220	+	Nonsense_Mutation	SNP	G	G	C	rs118203706		TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr9:135776220G>C	ENST00000298552.3	-	20	2728	c.2507C>G	c.(2506-2508)tCa>tGa	p.S836*	TSC1_ENST00000440111.2_Nonsense_Mutation_p.S836*|TSC1_ENST00000545250.1_Nonsense_Mutation_p.S785*	NM_000368.4|NM_001162426.1|NM_001162427.1	NP_000359.1|NP_001155898.1|NP_001155899.1	Q92574	TSC1_HUMAN	tuberous sclerosis 1	836					activation of Rho GTPase activity|cell cycle arrest|cell-matrix adhesion|insulin receptor signaling pathway|negative regulation of cell proliferation|negative regulation of protein ubiquitination|negative regulation of TOR signaling cascade|negative regulation of translation|positive regulation of focal adhesion assembly|regulation of phosphoprotein phosphatase activity|regulation of stress fiber assembly|rRNA export from nucleus	cell cortex|lamellipodium|membrane|TSC1-TSC2 complex	chaperone binding|protein N-terminus binding	p.?(1)		NS(1)|bone(1)|breast(3)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(9)|lung(20)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	65				OV - Ovarian serous cystadenocarcinoma(145;4.32e-08)|Epithelial(140;2.72e-06)		CTCACTGTTTGAGAGCTAACC	0.448000			"""D, Mis, N, F, S"""			"""hamartoma, renal cell"""			Tuberous Sclerosis				20	69					0	0	0.008871	0	0
MUC15	143662	broad.mit.edu	37	11	26587346	26587346	+	Silent	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr11:26587346C>T	ENST00000436318.2	-	2	274	c.141G>A	c.(139-141)ggG>ggA	p.G47G	MUC15_ENST00000281268.8_Silent_p.G47G|ANO3_ENST00000531568.1_Intron|ANO3_ENST00000256737.3_Intron|MUC15_ENST00000529533.1_Silent_p.G47G|ANO3_ENST00000525139.1_Intron|MUC15_ENST00000527569.1_Silent_p.G47G|MUC15_ENST00000455601.2_Silent_p.G20G|ANO3_ENST00000537978.1_Intron			Q8N387	MUC15_HUMAN	mucin 15, cell surface associated	20						extracellular region|integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	25						TTCCATGGCTCCCCGATAGAA	0.333000													12	119					0	0	0.000978	0	0
APC	324	broad.mit.edu	37	5	112177901	112177901	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr5:112177901C>T	ENST00000457016.1	+	16	6990	c.6610C>T	c.(6610-6612)Cga>Tga	p.R2204*	CTC-554D6.1_ENST00000520401.1_Intron|APC_ENST00000257430.4_Nonsense_Mutation_p.R2204*|APC_ENST00000508376.2_Nonsense_Mutation_p.R2204*			P25054	APC_HUMAN	adenomatous polyposis coli	2204	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.?(1)		NS(7)|adrenal_gland(6)|biliary_tract(5)|bone(6)|breast(29)|central_nervous_system(12)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(2768)|liver(15)|lung(39)|oesophagus(1)|ovary(12)|pancreas(27)|prostate(15)|salivary_gland(2)|skin(14)|small_intestine(34)|soft_tissue(55)|stomach(136)|thyroid(22)|upper_aerodigestive_tract(8)|urinary_tract(20)	3261		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		TGGAAAAGTTCGATCTAATTC	0.363000		12	"""D, Mis, N, F, S"""		"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""	"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""			Turcot syndrome;Hereditary Desmoid Disease;Familial Adenomatous Polyposis	TSP Lung(16;0.13)			18	104					0	0	0.004990	0	0
ZNF814	730051	broad.mit.edu	37	19	58388326	58388326	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr19:58388326G>A	ENST00000435989.2	-	2	355	c.121C>T	c.(121-123)Cgt>Tgt	p.R41C	CTD-2583A14.9_ENST00000602124.1_3'UTR|ZNF814_ENST00000597832.1_Missense_Mutation_p.R41C|ZNF814_ENST00000596604.1_Missense_Mutation_p.R41C|ZNF814_ENST00000600634.1_Missense_Mutation_p.R41C|ZNF814_ENST00000597807.1_Missense_Mutation_p.R41C|ZNF814_ENST00000597342.1_Missense_Mutation_p.R70C|ZNF814_ENST00000595295.1_Intron	NM_001144989.1	NP_001138461.1	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	41	KRAB.				regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			NS(1)|central_nervous_system(2)|endometrium(3)|kidney(9)|lung(2)|prostate(4)|skin(1)|urinary_tract(3)	25						GTCACATCACGGTACAGGCAT	0.493000													10	169					0	0	0.006214	0	0
PPP2R5D	5528	broad.mit.edu	37	6	42975720	42975720	+	Silent	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr6:42975720C>T	ENST00000485511.1	+	7	953	c.774C>T	c.(772-774)ctC>ctT	p.L258L	PPP2R5D_ENST00000472118.1_Silent_p.L250L|PPP2R5D_ENST00000394110.3_Silent_p.L226L|PPP2R5D_ENST00000461010.1_Silent_p.L152L	NM_001270476.1|NM_006245.3	NP_001257405.1|NP_006236.1	Q14738	2A5D_HUMAN	protein phosphatase 2, regulatory subunit B', delta	258					nervous system development|signal transduction	cytoplasm|nucleus|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	25			Colorectal(64;0.00237)|all cancers(41;0.00411)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0664)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			GGGACTTCCTCAAGACCATTT	0.552000													23	191					0	0	0.002780	0	0
NLRP7	199713	broad.mit.edu	37	19	55453094	55453094	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr19:55453094G>A	ENST00000446217.1	-	4	472	c.70C>T	c.(70-72)Cat>Tat	p.H24Y	NLRP7_ENST00000592784.1_5'UTR|NLRP7_ENST00000590030.1_5'UTR|NLRP7_ENST00000588756.1_5'UTR|NLRP7_ENST00000328092.5_5'UTR|NLRP7_ENST00000448121.2_5'UTR|NLRP7_ENST00000340844.2_5'UTR			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	0	DAPIN.						ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		CTCCGAGTATGAGACCTTAGG	0.453000													8	58					0	0	0.003080	0	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274360	39274360	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr17:39274360A>T	ENST00000391413.2	-	1	246	c.208T>A	c.(208-210)Tgc>Agc	p.C70S		NM_033059.3	NP_149048.2	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	70	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].		Missing (in allele KAP4.14).			keratin filament				endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|lung(8)|prostate(5)|skin(1)	33		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			CTGGAGATGCAGCATCTGGGG	0.667000													5	151					0	0	0.001984	0	0
SNED1	25992	broad.mit.edu	37	2	241991807	241991807	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr2:241991807G>A	ENST00000310397.8	+	15	2005	c.2005G>A	c.(2005-2007)Ggg>Agg	p.G669R	SNED1_ENST00000342631.6_Missense_Mutation_p.G669R|AC005237.4_ENST00000458377.1_RNA|SNED1_ENST00000401884.1_Missense_Mutation_p.G669R|SNED1_ENST00000405547.3_Missense_Mutation_p.G669R|SNED1_ENST00000469006.1_3'UTR	NM_001080437.1	NP_001073906.1	Q8TER0	SNED1_HUMAN	sushi, nidogen and EGF-like domains 1	669	EGF-like 10.				cell-matrix adhesion	extracellular region	calcium ion binding			NS(1)|breast(1)|central_nervous_system(3)|kidney(2)|large_intestine(6)|lung(4)|ovary(3)|prostate(3)|upper_aerodigestive_tract(1)	24		all_cancers(19;7.48e-31)|all_epithelial(40;1.35e-12)|Breast(86;0.000148)|Renal(207;0.00528)|Ovarian(221;0.104)|Esophageal squamous(248;0.131)|all_lung(227;0.17)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;6.46e-32)|all cancers(36;6.23e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.1e-14)|Kidney(56;6.35e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.98e-08)|BRCA - Breast invasive adenocarcinoma(100;3.66e-06)|Lung(119;0.00072)|LUSC - Lung squamous cell carcinoma(224;0.00553)|Colorectal(34;0.0162)|COAD - Colon adenocarcinoma(134;0.109)		GTGTGTGAATGGGGGCACCTG	0.647000													10	37					0	0	0.001368	0	0
SPEN	23013	broad.mit.edu	37	1	16261743	16261743	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr1:16261743C>T	ENST00000375759.3	+	11	9212	c.9008C>T	c.(9007-9009)tCg>tTg	p.S3003L		NM_015001.2	NP_055816.2	Q96T58	MINT_HUMAN	spen family transcriptional repressor	3003					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(5)|endometrium(16)|kidney(18)|large_intestine(27)|liver(2)|lung(37)|ovary(7)|prostate(7)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	149		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		CATGTCCCCTCGGGGCCCAGC	0.607000													15	109					0	0	0.003163	0	0
CTNND2	1501	broad.mit.edu	37	5	11199687	11199687	+	Silent	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr5:11199687C>T	ENST00000304623.8	-	11	2037	c.1848G>A	c.(1846-1848)ctG>ctA	p.L616L	CTNND2_ENST00000495388.2_5'UTR|CTNND2_ENST00000359640.2_Silent_p.L616L|CTNND2_ENST00000503622.1_Silent_p.L279L|CTNND2_ENST00000511377.1_Silent_p.L525L|CTNND2_ENST00000458100.2_Silent_p.L183L	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	616					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						CCAGGTTTCTCAGAGCTCCAC	0.522000													27	187					0	0	0.004656	0	0
AKAP9	10142	broad.mit.edu	37	7	91730214	91730214	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr7:91730214C>G	ENST00000359028.2	+	45	11178	c.10953C>G	c.(10951-10953)atC>atG	p.I3651M	AKAP9_ENST00000356239.3_Missense_Mutation_p.I3647M|AKAP9_ENST00000358100.2_Missense_Mutation_p.I3597M			Q99996	AKAP9_HUMAN	A kinase (PRKA) anchor protein 9	3651					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			NS(1)|autonomic_ganglia(2)|breast(14)|central_nervous_system(3)|cervix(1)|endometrium(13)|kidney(12)|large_intestine(35)|lung(49)|ovary(8)|prostate(6)|skin(8)|stomach(1)|urinary_tract(2)	155	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			TTGAAGCCATCATTGCCTCTG	0.403000			T	BRAF	papillary thyroid								14	111					0	0	0.002450	0	0
TBC1D2B	23102	broad.mit.edu	37	15	78290635	78290635	+	Missense_Mutation	SNP	C	C	T	rs117285325	by1000genomes	TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr15:78290635C>T	ENST00000409931.3	-	13	2778	c.2707G>A	c.(2707-2709)Gac>Aac	p.D903N	TBC1D2B_ENST00000300584.3_Missense_Mutation_p.R920Q|TBC1D2B_ENST00000492078.1_5'UTR			Q9UPU7	TBD2B_HUMAN	TBC1 domain family, member 2B	0						intracellular	protein binding|Rab GTPase activator activity	p.D903N(3)|p.R920Q(1)		breast(3)|cervix(2)|endometrium(4)|kidney(1)|large_intestine(7)|lung(2)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	26						GTAGGCGCGTCGGTTCCGGAT	0.617000													3	19					0	0	0.001168	0	0
TRIM42	287015	broad.mit.edu	37	3	140401604	140401604	+	Silent	SNP	C	C	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr3:140401604C>A	ENST00000286349.3	+	2	833	c.642C>A	c.(640-642)ctC>ctA	p.L214L		NM_152616.4	NP_689829.3	Q8IWZ5	TRI42_HUMAN	tripartite motif containing 42	214						intracellular	zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(11)|lung(33)|ovary(2)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	69						ACGGGCGTCTCACCAAGCGCT	0.607000													23	168					3.62473e-10	7.05806e-10	0.001882	1	0
RECQL4	9401	broad.mit.edu	37	8	145737119	145737119	+	Silent	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr8:145737119C>T	ENST00000428558.2	-	21	3488	c.3447G>A	c.(3445-3447)ctG>ctA	p.L1149L	RECQL4_ENST00000532237.1_5'UTR	NM_004260.3	NP_004251.3	O94761	RECQ4_HUMAN	RecQ protein-like 4	1149					DNA duplex unwinding|DNA recombination|DNA repair	cytoplasm|nucleus	ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|DNA strand annealing activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|lung(10)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	26	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			CCTCTGGCCTCAGGGACAGGA	0.672000			"""N, F, S"""			"""osteosarcoma, skin basal and sqamous cell"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Rothmund-Thomson syndrome;RAPADILINO syndrome;Baller-Gerold syndrome				27	143					0	0	0.006320	0	0
ASTN1	460	broad.mit.edu	37	1	176934347	176934347	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr1:176934347C>T	ENST00000367654.3	-	9	1785	c.1574G>A	c.(1573-1575)cGa>cAa	p.R525Q	ASTN1_ENST00000424564.2_Missense_Mutation_p.R517Q|ASTN1_ENST00000281881.3_5'UTR|ASTN1_ENST00000367657.3_Missense_Mutation_p.R517Q|ASTN1_ENST00000361833.2_Missense_Mutation_p.R517Q	NM_004319.1	NP_004310.1	O14525	ASTN1_HUMAN	astrotactin 1						cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						GTCAAAGCCTCGCTGAAATAT	0.418000													14	100					0	0	0.002450	0	0
GNAS	2778	broad.mit.edu	37	20	57429130	57429130	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr20:57429130G>C	ENST00000306120.3	+	1	620	c.620G>C	c.(619-621)cGa>cCa	p.R207P	GNAS_ENST00000464624.2_3'UTR|GNAS_ENST00000371102.4_Silent_p.A270A|GNAS_ENST00000371100.4_Silent_p.A270A|GNAS_ENST00000371098.2_Intron|GNAS_ENST00000371075.3_Intron|GNAS_ENST00000313949.7_Intron|GNAS_ENST00000371099.2_Silent_p.A270A			P63092	GNAS2_HUMAN	GNAS complex locus	0					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			adrenal_gland(12)|autonomic_ganglia(1)|biliary_tract(5)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(37)|liver(9)|lung(9)|ovary(16)|pancreas(56)|parathyroid(5)|pituitary(228)|prostate(2)|small_intestine(1)|stomach(1)|testis(2)|thyroid(35)|upper_aerodigestive_tract(3)|urinary_tract(1)	441	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			CTCCCGCCGCGAACGCGCCTC	0.687000			Mis		pituitary adenoma		"""McCune-Albright syndrome; pseudohypoparathyroidism, type IA"""			TSP Lung(22;0.16)			5	37					0	0	0.000602	0	0
LINC01317	104355287	broad.mit.edu	37	2	33952684	33952684	+	RNA	SNP	G	G	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr2:33952684G>A	ENST00000366209.2	+	0	68				MYADML_ENST00000474610.1_RNA																							GGGAACGGCCGTGGGACAGGA	0.647000													16	66					0	0	0.003163	0	0
PLA2G4C	8605	broad.mit.edu	37	19	48602975	48602975	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr19:48602975G>C	ENST00000354276.3	-	5	727	c.400C>G	c.(400-402)Ctg>Gtg	p.L134V	PLA2G4C_ENST00000413144.2_Missense_Mutation_p.L134V|PLA2G4C_ENST00000599921.1_Missense_Mutation_p.L134V|PLA2G4C_ENST00000599111.1_Missense_Mutation_p.L144V	NM_001159323.1	NP_001152795.1	Q9UP65	PA24C_HUMAN	phospholipase A2, group IVC (cytosolic, calcium-independent)	134	PLA2c.				arachidonic acid metabolic process|glycerophospholipid catabolic process|inflammatory response|intracellular signal transduction|parturition	cytosol|membrane	calcium-independent phospholipase A2 activity|phospholipid binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(12)|lung(13)|ovary(2)|prostate(1)|skin(3)	38		all_cancers(25;2.84e-05)|all_lung(116;4.62e-05)|Lung NSC(112;7.61e-05)|all_epithelial(76;0.000192)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;8.09e-05)|all cancers(93;0.000517)|Epithelial(262;0.0135)|GBM - Glioblastoma multiforme(486;0.0717)		AAGTCGGTCAGAGAGTAATTC	0.527000													32	199					0	0	0.008361	0	0
CSE1L	1434	broad.mit.edu	37	20	47682988	47682988	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr20:47682988G>C	ENST00000262982.2	+	5	540	c.417G>C	c.(415-417)caG>caC	p.Q139H	CSE1L_ENST00000542325.1_Intron|CSE1L_ENST00000396192.3_Missense_Mutation_p.Q139H	NM_001256135.1|NM_001316.3	NP_001243064.1|NP_001307.2	P55060	XPO2_HUMAN	CSE1 chromosome segregation 1-like (yeast)	139					apoptosis|cell proliferation|intracellular protein transport	cytoplasm|nucleus	importin-alpha export receptor activity			breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(11)|ovary(1)|prostate(3)|skin(2)|urinary_tract(2)	35			BRCA - Breast invasive adenocarcinoma(12;0.000491)|Colorectal(8;0.198)			ATCGCTTTCAGAGTGGAGATT	0.353000													13	95					0	0	0.001855	0	0
ZBTB47	92999	broad.mit.edu	37	3	42703079	42703079	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr3:42703079G>C	ENST00000457842.3	+	3	1857	c.448G>C	c.(448-450)Gag>Cag	p.E150Q	ZBTB47_ENST00000232974.6_Missense_Mutation_p.E526Q|ZBTB47_ENST00000505904.1_Missense_Mutation_p.E72Q	NM_145166.3	NP_660149.2	Q9UFB7	ZBT47_HUMAN	zinc finger and BTB domain containing 47	150					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|large_intestine(2)|lung(3)|ovary(1)	13				KIRC - Kidney renal clear cell carcinoma(284;0.216)		CGAGATCTGTGAGAAGAAGTT	0.512000													13	65					0	0	0.001368	0	0
RAB3D	9545	broad.mit.edu	37	19	11447923	11447923	+	Silent	SNP	G	G	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr19:11447923G>A	ENST00000222120.3	-	2	413	c.153C>T	c.(151-153)ttC>ttT	p.F51F	RAB3D_ENST00000589655.1_Silent_p.F51F	NM_004283.3	NP_004274.1	O95716	RAB3D_HUMAN	RAB3D, member RAS oncogene family	51					exocytosis|protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			cervix(1)|endometrium(3)|kidney(1)|large_intestine(3)|liver(1)|lung(3)|ovary(2)	14						CAGTACTGACGAAGGCGGGAG	0.537000													55	351					0	0	0.003610	0	0
KRTAP10-1	386677	broad.mit.edu	37	21	45959752	45959752	+	Silent	SNP	G	G	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr21:45959752G>A	ENST00000400375.1	-	1	326	c.282C>T	c.(280-282)ccC>ccT	p.P94P	TSPEAR_ENST00000397916.1_Intron|TSPEAR_ENST00000323084.4_Intron	NM_198691.2	NP_941964.2	P60331	KR101_HUMAN	keratin associated protein 10-1	94	24 X 5 AA repeats of C-C-X(3).					keratin filament				breast(1)|central_nervous_system(1)|endometrium(1)|lung(3)|prostate(4)|skin(1)	11						cctgctggcagggggaggagg	0.662000													5	227					0	0	0.003080	0	0
RHOB	388	broad.mit.edu	37	2	20647689	20647689	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr2:20647689G>C	ENST00000272233.4	+	1	855	c.463G>C	c.(463-465)Gac>Cac	p.D155H		NM_004040.2	NP_004031.1	P62745	RHOB_HUMAN	ras homolog family member B	155					angiogenesis|axon guidance|cell adhesion|endosome to lysosome transport|negative regulation of cell cycle|platelet activation|positive regulation of angiogenesis|protein transport|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|transformed cell apoptosis	cytosol|late endosome membrane|nucleus|plasma membrane	GTP binding|GTPase activity|protein binding			breast(1)|kidney(1)|lung(2)|ovary(1)|urinary_tract(2)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)	all_epithelial(98;4.19e-09)|Lung NSC(108;0.00452)|Ovarian(717;0.0164)		OV - Ovarian serous cystadenocarcinoma(76;1.14e-22)|Epithelial(75;7.84e-19)		CCAAGCCTACGACTACCTCGA	0.682000													31	211					0	0	0.003271	0	0
STXBP5L	9515	broad.mit.edu	37	3	120871362	120871362	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr3:120871362G>C	ENST00000273666.6	+	8	979	c.708G>C	c.(706-708)tgG>tgC	p.W236C	STXBP5L_ENST00000492541.1_Missense_Mutation_p.W236C|STXBP5L_ENST00000497029.1_Missense_Mutation_p.W236C|STXBP5L_ENST00000471454.1_Missense_Mutation_p.W236C|STXBP5L_ENST00000472879.1_Missense_Mutation_p.W236C	NM_014980.2	NP_055795.1	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	236					exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(12)|lung(28)|ovary(7)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				GBM - Glioblastoma multiforme(114;0.0694)		TAGTATTCTGGGACTTGAAAT	0.313000													9	96					0	0	0.006214	0	0
TCN1	6947	broad.mit.edu	37	11	59622251	59622251	+	Nonsense_Mutation	SNP	G	G	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr11:59622251G>C	ENST00000257264.3	-	7	1099	c.995C>G	c.(994-996)tCa>tGa	p.S332*	TCN1_ENST00000532419.1_5'UTR	NM_001062.3	NP_001053.2	P20061	TCO1_HUMAN	transcobalamin I (vitamin B12 binding protein, R binder family)	332					cobalamin metabolic process|cobalamin transport|cobalt ion transport	extracellular region	cobalamin binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(15)|ovary(2)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29		all_epithelial(135;0.198)			Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GGAGATATATGATTGTGAGTC	0.413000													15	100					0	0	0.002450	0	0
JAK2	3717	broad.mit.edu	37	9	5054847	5054847	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr9:5054847G>A	ENST00000381652.3	+	7	1393	c.899G>A	c.(898-900)aGa>aAa	p.R300K	JAK2_ENST00000544510.1_Missense_Mutation_p.R151K|JAK2_ENST00000539801.1_Missense_Mutation_p.R300K	NM_004972.3	NP_004963.1	O60674	JAK2_HUMAN	Janus kinase 2	300	FERM.				actin filament polymerization|activation of caspase activity by protein phosphorylation|activation of JAK2 kinase activity|blood coagulation|cellular component movement|erythrocyte differentiation|interferon-gamma-mediated signaling pathway|interleukin-12-mediated signaling pathway|JAK-STAT cascade involved in growth hormone signaling pathway|mammary gland epithelium development|mesoderm development|negative regulation of cell proliferation|negative regulation of DNA binding|positive regulation of apoptosis|positive regulation of cell-substrate adhesion|positive regulation of growth hormone receptor signaling pathway|positive regulation of nitric-oxide synthase 2 biosynthetic process|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|protein autophosphorylation|regulation of inflammatory response|regulation of interferon-gamma-mediated signaling pathway|response to antibiotic|response to lipopolysaccharide|STAT protein import into nucleus|tumor necrosis factor-mediated signaling pathway|tyrosine phosphorylation of STAT protein	caveola|cytoskeleton|cytosol|endomembrane system|nucleus	ATP binding|growth hormone receptor binding|heme binding|histone binding|histone kinase activity (H3-Y41 specific)|interleukin-12 receptor binding|non-membrane spanning protein tyrosine kinase activity|protein kinase binding|SH2 domain binding		BCR/JAK2(6)|SSBP2/JAK2(4)|SEC31A/JAK2(4)|ETV6/JAK2(11)|PCM1/JAK2(30)|PAX5/JAK2(18)	breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(32944)|kidney(4)|large_intestine(10)|liver(1)|lung(20)|ovary(3)|prostate(4)|skin(2)|urinary_tract(1)	32998	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.0198)|Breast(48;0.147)		GBM - Glioblastoma multiforme(50;0.0237)|Lung(218;0.133)		CAGTGGTCAAGAGGGAAACAT	0.348000		1	"""T, Mis, O"""	"""ETV6, PCM1, BCR"""	"""ALL, AML, MPD,  CML"""				Polycythemia Vera, Familial				9	50					0	0	0.004482	0	0
GNA13	10672	broad.mit.edu	37	17	63010910	63010910	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr17:63010910C>G	ENST00000439174.2	-	4	844	c.599G>C	c.(598-600)aGa>aCa	p.R200T	GNA13_ENST00000541118.1_Missense_Mutation_p.R105T	NM_006572.4	NP_006563.2	Q14344	GNA13_HUMAN	guanine nucleotide binding protein (G protein), alpha 13	200					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase D activity|cellular component movement|platelet activation|Rho protein signal transduction	brush border membrane|heterotrimeric G-protein complex|melanosome	D5 dopamine receptor binding|G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|signal transducer activity|type 1 angiotensin receptor binding	p.R200K(1)		breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(14)|kidney(2)|large_intestine(4)|lung(6)|urinary_tract(1)	34						GGTGGGTCTTCTGGCAAGCAG	0.358000													22	106					0	0	0.002299	0	0
SLAMF7	57823	broad.mit.edu	37	1	160721198	160721198	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr1:160721198C>G	ENST00000368043.3	+	5	870	c.833C>G	c.(832-834)tCt>tGt	p.S278C	SLAMF7_ENST00000441662.2_Missense_Mutation_p.S147C|SLAMF7_ENST00000458104.2_Intron|SLAMF7_ENST00000359331.4_Intron|SLAMF7_ENST00000458602.2_Missense_Mutation_p.S131C|SLAMF7_ENST00000368042.3_Missense_Mutation_p.S171C|SLAMF7_ENST00000444090.2_Intron	NM_001282595.1|NM_021181.3	NP_001269524.1|NP_067004.3	Q9NQ25	SLAF7_HUMAN	SLAM family member 7	278					cell adhesion|natural killer cell activation|natural killer cell mediated cytotoxicity	integral to membrane	receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(10)|ovary(1)|prostate(1)|skin(4)	24	all_cancers(52;2.63e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			TGCCCCCATTCTGGAGAGAAC	0.468000													25	160					0	0	0.007291	0	0
TPCN1	53373	broad.mit.edu	37	12	113710476	113710476	+	Silent	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr12:113710476C>T	ENST00000550785.1	+	9	1147	c.978C>T	c.(976-978)ttC>ttT	p.F326F	TPCN1_ENST00000541517.1_Silent_p.F326F|TPCN1_ENST00000392569.4_Silent_p.F186F|TPCN1_ENST00000335509.6_Silent_p.F254F	NM_001143819.1	NP_001137291.1	Q9ULQ1	TPC1_HUMAN	two pore segment channel 1	254						endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated ion channel activity			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(16)|ovary(2)|prostate(3)|skin(3)|urinary_tract(1)	40						TCTACTTGTTCTCCCCTAACC	0.473000													79	1326					0	0	0.003610	0	0
BDH1	622	broad.mit.edu	37	3	197241175	197241175	+	Silent	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr3:197241175C>T	ENST00000392379.1	-	7	923	c.522G>A	c.(520-522)cgG>cgA	p.R174R	BDH1_ENST00000441275.1_Silent_p.R87R|BDH1_ENST00000392378.2_Silent_p.R174R|BDH1_ENST00000358186.2_Silent_p.R174R	NM_203314.2	NP_976059.1	Q02338	BDH_HUMAN	3-hydroxybutyrate dehydrogenase, type 1	174					cellular lipid metabolic process|ketone body biosynthetic process|ketone body catabolic process	mitochondrial matrix	3-hydroxybutyrate dehydrogenase activity			endometrium(2)|large_intestine(1)|lung(6)|ovary(1)|skin(1)	11	all_cancers(143;3.35e-10)|Ovarian(172;0.0418)|Breast(254;0.0437)	Lung NSC(153;0.118)	Epithelial(36;3.52e-24)|all cancers(36;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(49;2.32e-19)|LUSC - Lung squamous cell carcinoma(58;1.02e-06)|Lung(62;1.34e-06)	GBM - Glioblastoma multiforme(93;0.0977)	NADH(DB00157)	ATTTCGTCATCCGCACTGTGC	0.572000													11	62					0	0	0.008291	0	0
PHACTR3	116154	broad.mit.edu	37	20	58318164	58318164	+	Missense_Mutation	SNP	G	G	A	rs149282803		TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr20:58318164G>A	ENST00000371015.1	+	2	588	c.121G>A	c.(121-123)Gag>Aag	p.E41K	PHACTR3_ENST00000395639.4_5'UTR|PHACTR3_ENST00000361300.4_5'UTR|PHACTR3_ENST00000541461.1_5'UTR|PHACTR3_ENST00000355648.4_5'UTR|PHACTR3_ENST00000359926.3_Missense_Mutation_p.E38K|PHACTR3_ENST00000395636.2_5'UTR	NM_001281507.1|NM_080672.3	NP_001268436.1|NP_542403.1	Q96KR7	PHAR3_HUMAN	phosphatase and actin regulator 3	41						nuclear matrix	actin binding|protein phosphatase inhibitor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|liver(2)|lung(32)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	59	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;2.76e-09)			TCTTCCAGATGAGATGGACCA	0.587000													15	176					0	0	0.004990	0	0
KCNH3	23416	broad.mit.edu	37	12	49937815	49937815	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr12:49937815C>T	ENST00000257981.6	+	6	1201	c.941C>T	c.(940-942)gCg>gTg	p.A314V		NM_012284.1	NP_036416.1	Q9ULD8	KCNH3_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 3	314					regulation of transcription, DNA-dependent	integral to membrane	two-component sensor activity|voltage-gated potassium channel activity			NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(20)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	36						GTCATCGCAGCGCTGCCCTTT	0.622000													17	157					0	0	0.004990	0	0
MGA	23269	broad.mit.edu	37	15	42041627	42041627	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr15:42041627C>G	ENST00000219905.7	+	17	6003	c.5822C>G	c.(5821-5823)tCt>tGt	p.S1941C	MGA_ENST00000570161.1_Missense_Mutation_p.S1941C|MGA_ENST00000566586.1_Missense_Mutation_p.S1732C|MGA_ENST00000389936.4_Missense_Mutation_p.S1902C|MGA_ENST00000545763.1_Missense_Mutation_p.S1732C	NM_001164273.1	NP_001157745.1	Q8IWI9	MGAP_HUMAN	MGA, MAX dimerization protein	1902						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(33)|ovary(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		CCTCTCCAGTCTGGTAGTTTT	0.448000													14	50					0	0	0.003163	0	0
MYH9	4627	broad.mit.edu	37	22	36717809	36717809	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr22:36717809C>T	ENST00000216181.5	-	7	993	c.763G>A	c.(763-765)Gag>Aag	p.E255K		NM_002473.4	NP_002464.1	P35579	MYH9_HUMAN	myosin, heavy chain 9, non-muscle	255	Myosin head-like.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			NS(1)|breast(8)|central_nervous_system(3)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(16)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(3)	86						ATACAAGTCTCAATGTTGGCT	0.478000			T	ALK	ALCL		"""Deafness, autosomal dominant 17, Epstein syndrome, Fechtner syndrome, May-Hegglin anomaly, Sebastian syndrome"""		Hereditary Macrothrombocytopenia, MYH9-associated				24	98					0	0	0.003954	0	0
HOOK3	84376	broad.mit.edu	37	8	42780704	42780704	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr8:42780704C>G	ENST00000307602.4	+	3	348	c.148C>G	c.(148-150)Cct>Gct	p.P50A		NM_032410.3	NP_115786.1	Q86VS8	HOOK3_HUMAN	hook microtubule-tethering protein 3	50	Sufficient for interaction with microtubules.				cytoplasmic microtubule organization|early endosome to late endosome transport|endosome organization|endosome to lysosome transport|Golgi localization|interkinetic nuclear migration|lysosome organization|microtubule anchoring|negative regulation of neurogenesis|protein localization to centrosome|protein transport	cis-Golgi network|FHF complex|microtubule|pericentriolar material	identical protein binding|microtubule binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	31	Ovarian(28;0.01)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.000105)|Lung NSC(58;0.000419)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.129)	Lung(22;0.048)|LUSC - Lung squamous cell carcinoma(45;0.114)			TTGCAGAGATCCTGCATATTT	0.294000			T	RET	papillary thyroid								12	62					0	0	0.001368	0	0
C17orf70	80233	broad.mit.edu	37	17	79507956	79507956	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr17:79507956C>G	ENST00000537152.1	-	9	2607	c.2082G>C	c.(2080-2082)caG>caC	p.Q694H	C17orf70_ENST00000425898.2_Missense_Mutation_p.Q494H|C17orf70_ENST00000327787.8_Missense_Mutation_p.Q845H	NM_025161.5	NP_079437.5	Q0VG06	FP100_HUMAN	chromosome 17 open reading frame 70	845					DNA repair	cytoplasm|intermediate filament cytoskeleton|nucleoplasm	DNA binding			breast(1)|central_nervous_system(1)|endometrium(1)|lung(11)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	19	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0371)			CGCGCAGGGTCTGCACCTCCC	0.682000													7	17					0	0	0.001984	0	0
SHPRH	257218	broad.mit.edu	37	6	146216072	146216072	+	Silent	SNP	C	C	G			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr6:146216072C>G	ENST00000367503.3	-	26	4967	c.4569G>C	c.(4567-4569)ctG>ctC	p.L1523L	SHPRH_ENST00000438092.2_Silent_p.L1523L|SHPRH_ENST00000367505.2_Silent_p.L1519L|SHPRH_ENST00000275233.7_Silent_p.L1519L	NM_001042683.2	NP_001036148.2	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase	1519	Helicase C-terminal.				DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(33)|ovary(3)|pancreas(2)|prostate(7)|skin(1)|urinary_tract(1)	79		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		GTATTTTCATCAGAGTTCTGA	0.368000													34	212					0	0	0.007835	0	0
MUC16	94025	broad.mit.edu	37	19	9058631	9058631	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr19:9058631G>T	ENST00000397910.4	-	3	29018	c.28815C>A	c.(28813-28815)taC>taA	p.Y9605*		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9607	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGGGCATCTTGTAAAGGACAG	0.527000													20	48					4.96729e-08	9.57745e-08	0.008871	1	0
PRRC2C	23215	broad.mit.edu	37	1	171509204	171509204	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr1:171509204G>C	ENST00000367742.3	+	16	2841	c.2599G>C	c.(2599-2601)Gaa>Caa	p.E867Q	PRRC2C_ENST00000392078.3_Missense_Mutation_p.E867Q|PRRC2C_ENST00000338920.4_Missense_Mutation_p.E865Q|PRRC2C_ENST00000426496.2_Missense_Mutation_p.E865Q			Q9Y520	PRC2C_HUMAN	proline-rich coiled-coil 2C	865							protein C-terminus binding										CTTTATCAGAGAATCAAGTGA	0.408000													35	185					0	0	0.003755	0	0
OCRL	4952	broad.mit.edu	37	X	128694596	128694596	+	Silent	SNP	T	T	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chrX:128694596T>C	ENST00000371113.4	+	9	957	c.792T>C	c.(790-792)tgT>tgC	p.C264C	OCRL_ENST00000357121.5_Silent_p.C264C	NM_000276.3	NP_000267.2	Q01968	OCRL_HUMAN	oculocerebrorenal syndrome of Lowe	264					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	clathrin-coated vesicle|cytosol|early endosome|Golgi stack|Golgi-associated vesicle	GTPase activator activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			breast(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(24)|ovary(2)|upper_aerodigestive_tract(3)	48						GGCTGAACTGTGATCCCAATC	0.373000													16	45					0	0	0.004990	0	0
HCG27	253018	broad.mit.edu	37	6	31170406	31170406	+	Silent	SNP	G	G	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr6:31170406G>C	ENST00000383331.4	+	2	381	c.381G>C	c.(379-381)gtG>gtC	p.V127V	HCG27_ENST00000415276.1_3'UTR																							TCCTCAGTGTGACTGGGTGAA	0.637000													8	59					0	0	0.003080	0	0
TSSC2	650368	broad.mit.edu	37	11	3427845	3427845	+	RNA	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr11:3427845C>T	ENST00000529482.1	+	0	962																											CTTCAAGTGGCAGGAGCAGAA	0.587000													5	65					0	0	0.000602	0	0
METTL3	56339	broad.mit.edu	37	14	21971651	21971651	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr14:21971651C>A	ENST00000298717.4	-	3	539	c.388G>T	c.(388-390)Gag>Tag	p.E130*	METTL3_ENST00000538267.1_Nonsense_Mutation_p.E130*	NM_019852.3	NP_062826.2	Q86U44	MTA70_HUMAN	methyltransferase like 3	130					gene expression	nuclear speck	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity|RNA binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|pancreas(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	20	all_cancers(95;0.000628)		Epithelial(56;6.61e-06)	GBM - Glioblastoma multiforme(265;0.0146)		CGCTTTACCTCAATCAACTCC	0.502000													11	65					4.84862e-15	9.66447e-15	0.000978	1	0
NEK10	152110	broad.mit.edu	37	3	27183070	27183070	+	Nonsense_Mutation	SNP	G	G	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr3:27183070G>C	ENST00000429845.2	-	34	3406	c.3044C>G	c.(3043-3045)tCa>tGa	p.S1015*	NEK10_ENST00000498182.1_5'UTR|NEK10_ENST00000295720.6_Nonsense_Mutation_p.S327*|NEK10_ENST00000383770.3_Nonsense_Mutation_p.S270*|NEK10_ENST00000383771.4_Nonsense_Mutation_p.S317*			Q6ZWH5	NEK10_HUMAN	NIMA-related kinase 10	1015							ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						AATTCCTGCTGATGCTGTGGG	0.348000													17	75					0	0	0.004990	0	0
GJC2	57165	broad.mit.edu	37	1	228346668	228346668	+	Silent	SNP	C	C	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr1:228346668C>A	ENST00000366714.2	+	2	1384	c.1209C>A	c.(1207-1209)gtC>gtA	p.V403V		NM_020435.3	NP_065168.2	Q5T442	CXG2_HUMAN	gap junction protein, gamma 2, 47kDa	403					cell death	connexon complex|integral to membrane				endometrium(1)|kidney(1)|large_intestine(1)|lung(4)	7		Prostate(94;0.0405)				CGGGCACTGTCGGGGAGCAGG	0.761000													4	24					0.00024832	0.000465107	0.000248	1	0
RPS2	6187	broad.mit.edu	37	16	2012533	2012533	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr16:2012533G>A	ENST00000529806.1	-	4	770	c.584C>T	c.(583-585)tCa>tTa	p.S195L	RPS2_ENST00000343262.4_Missense_Mutation_p.S225L|RPS2_ENST00000526522.1_Missense_Mutation_p.S167L|RPS2_ENST00000530225.1_Intron			P15880	RS2_HUMAN	ribosomal protein S2	225					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleoplasm	fibroblast growth factor 1 binding|fibroblast growth factor 3 binding|RNA binding|structural constituent of ribosome			endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|urinary_tract(2)	7						GCCCCGGGCTGAGGTGTAGCA	0.612000													7	88					0	0	0.001984	0	0
FGR	2268	broad.mit.edu	37	1	27948111	27948111	+	Silent	SNP	G	G	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr1:27948111G>A	ENST00000374005.3	-	5	675	c.387C>T	c.(385-387)ccC>ccT	p.P129P	FGR_ENST00000399173.1_Silent_p.P129P|FGR_ENST00000545953.1_Intron|FGR_ENST00000374004.1_Silent_p.P129P	NM_005248.2	NP_005239.1	P09769	FGR_HUMAN	feline Gardner-Rasheed sarcoma viral oncogene homolog	129	SH3.				platelet activation|response to virus	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(4)	16		all_lung(284;2.05e-05)|Colorectal(325;3.46e-05)|Lung NSC(340;3.67e-05)|Renal(390;0.00121)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		CGTAGTTGCTGGGAATGCAGC	0.577000													6	80					0	0	0.001984	0	0
RHOB	388	broad.mit.edu	37	2	20647344	20647344	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr2:20647344G>C	ENST00000272233.4	+	1	510	c.118G>C	c.(118-120)Gag>Cag	p.E40Q		NM_004040.2	NP_004031.1	P62745	RHOB_HUMAN	ras homolog family member B	40					angiogenesis|axon guidance|cell adhesion|endosome to lysosome transport|negative regulation of cell cycle|platelet activation|positive regulation of angiogenesis|protein transport|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|transformed cell apoptosis	cytosol|late endosome membrane|nucleus|plasma membrane	GTP binding|GTPase activity|protein binding			breast(1)|kidney(1)|lung(2)|ovary(1)|urinary_tract(2)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)	all_epithelial(98;4.19e-09)|Lung NSC(108;0.00452)|Ovarian(717;0.0164)		OV - Ovarian serous cystadenocarcinoma(76;1.14e-22)|Epithelial(75;7.84e-19)		CACCGTCTTCGAGAACTATGT	0.652000													13	84					0	0	0.001368	0	0
LRRC37A4P	55073	broad.mit.edu	37	17	43592074	43592074	+	RNA	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr17:43592074C>T	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							TTTGCACTTTCTAAAATGGAA	0.453000													7	166					0	0	0.004482	0	0
DOT1L	84444	broad.mit.edu	37	19	2185876	2185876	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr19:2185876G>A	ENST00000398665.3	+	3	184	c.148G>A	c.(148-150)Gat>Aat	p.D50N		NM_032482.2	NP_115871.1	Q8TEK3	DOT1L_HUMAN	DOT1-like histone H3K79 methyltransferase	50						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			NS(1)|breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(3)|lung(14)|ovary(2)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(9)	42		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGAAATCCCGGATCTCAAGCT	0.438000													90	555					0	0	0.003610	0	0
AEBP1	165	broad.mit.edu	37	7	44152430	44152430	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr7:44152430C>T	ENST00000223357.3	+	18	2796	c.2491C>T	c.(2491-2493)Cgc>Tgc	p.R831C	AEBP1_ENST00000450684.2_Missense_Mutation_p.R406C	NM_001129.3	NP_001120.3	Q8IUX7	AEBP1_HUMAN	AE binding protein 1	831	Interaction with PTEN (By similarity).				cell adhesion|muscle organ development|proteolysis|skeletal system development	cytoplasm|extracellular space|nucleus	DNA binding|metallocarboxypeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(13)|upper_aerodigestive_tract(2)	33						CGAGCCCTACCGCGGAGGCTG	0.677000													20	113					0	0	0.007413	0	0
KIAA2018	205717	broad.mit.edu	37	3	113374152	113374152	+	Nonsense_Mutation	SNP	G	G	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr3:113374152G>C	ENST00000316407.4	-	7	6787	c.6377C>G	c.(6376-6378)tCa>tGa	p.S2126*	KIAA2018_ENST00000478658.1_Nonsense_Mutation_p.S2126*|KIAA2018_ENST00000491165.1_Intron	NM_001009899.2	NP_001009899.2	Q68DE3	K2018_HUMAN	KIAA2018	2126					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			NS(1)|breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|liver(1)|lung(30)|ovary(8)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	80						ATAGGGGATTGAAATATCATT	0.433000													19	139					0	0	0.007413	0	0
SSPO	23145	broad.mit.edu	37	7	149479352	149479352	+	RNA	SNP	C	C	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr7:149479352C>A	ENST00000378016.2	+	0	1865							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			ATCTCCGTCTCCCTGGAGGAC	0.627000													7	33					5.18039e-06	9.89136e-06	0.003080	1	0
WASH6P	653440	broad.mit.edu	37	X	155252868	155252868	+	RNA	SNP	T	T	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chrX:155252868T>A	ENST00000285718.7	+	0	819				WASH6P_ENST00000461007.1_RNA														p.P304P(5)									TAGCCGAGCCTCTCAAGGCAG	0.632000													6	16					0	0	0.006214	0	0
PDCL	5082	broad.mit.edu	37	9	125582396	125582396	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr9:125582396G>A	ENST00000259467.4	-	4	1039	c.874C>T	c.(874-876)Cac>Tac	p.H292Y		NM_005388.4	NP_005379.3	Q13371	PHLP_HUMAN	phosducin-like	292					signal transduction|visual perception					endometrium(1)|large_intestine(2)|lung(5)|skin(1)|stomach(1)	10						TCCTCACTGTGACACGTGGCA	0.413000													12	85					0	0	0.001855	0	0
HIST1H4D	8360	broad.mit.edu	37	6	26189187	26189187	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr6:26189187G>A	ENST00000340756.2	-	1	117	c.118C>T	c.(118-120)Cgc>Tgc	p.R40C		NM_003539.3	NP_003530.1	P62805	H4_HUMAN	histone cluster 1, H4d	40					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			breast(2)|endometrium(2)|large_intestine(2)|lung(1)|prostate(1)	8		all_hematologic(11;0.196)				CCGCCGCGGCGAGCCAGGCGG	0.557000													11	111					0	0	0.000978	0	0
CCDC114	93233	broad.mit.edu	37	19	48806284	48806284	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr19:48806284C>T	ENST00000315396.7	-	9	1628	c.946G>A	c.(946-948)Gaa>Aaa	p.E316K		NM_144577.3	NP_653178.3	Q96M63	CC114_HUMAN	coiled-coil domain containing 114	316										cervix(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|stomach(1)	24		all_epithelial(76;9.64e-05)|all_lung(116;0.000147)|Lung NSC(112;0.000251)|Prostate(7;0.0187)|all_neural(266;0.0228)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000162)|Epithelial(262;0.0134)|GBM - Glioblastoma multiforme(486;0.0143)		TTGATCTCTTCCTGCACATGC	0.612000													13	88					0	0	0.002450	0	0
HNRNPDL	9987	broad.mit.edu	37	4	83348632	83348632	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr4:83348632A>T	ENST00000295470.5	-	4	1035	c.860T>A	c.(859-861)gTa>gAa	p.V287E	HNRNPDL_ENST00000502762.1_Missense_Mutation_p.V287E|HNRNPDL_ENST00000602300.1_Missense_Mutation_p.V168E|HNRNPDL_ENST00000349655.4_Missense_Mutation_p.V168E|HNRNPDL_ENST00000514511.1_5'UTR	NM_001207000.1|NM_031372.3	NP_001193929.1|NP_112740.1			heterogeneous nuclear ribonucleoprotein D-like																		CAATTTTTTTACTGGCTCTTC	0.289000													6	72					0	0	0.001168	0	0
CECR2	27443	broad.mit.edu	37	22	18029035	18029035	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr22:18029035G>A	ENST00000400573.5	+	17	3999	c.3992G>A	c.(3991-3993)cGg>cAg	p.R1331Q	CECR2_ENST00000400585.2_Missense_Mutation_p.R1189Q|CECR2_ENST00000262608.8_Missense_Mutation_p.R1332Q			Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2						chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding	p.R1331Q(1)		NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	59		all_epithelial(15;0.139)		Lung(27;0.146)		ACCCCTCAGCGGCCGGCCAGT	0.627000													4	87					0	0	0.000602	0	0
ZNF429	353088	broad.mit.edu	37	19	21719694	21719694	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr19:21719694C>T	ENST00000358491.4	+	4	1047	c.839C>T	c.(838-840)tCt>tTt	p.S280F	ZNF429_ENST00000597078.1_Intron	NM_001001415.2	NP_001001415.2	Q86V71	ZN429_HUMAN	zinc finger protein 429	280					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(13)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|soft_tissue(1)|upper_aerodigestive_tract(2)	34						AGAATTCATTCTGGAGAGAAG	0.378000													15	74					0	0	0.003163	0	0
BOD1L1	259282	broad.mit.edu	37	4	13605102	13605102	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr4:13605102C>T	ENST00000040738.5	-	10	3557	c.3422G>A	c.(3421-3423)cGc>cAc	p.R1141H		NM_148894.2	NP_683692.2	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division 1-like 1	1141							DNA binding										ATTATTATTGCGGTTGTCTTG	0.373000													7	200					0	0	0.001984	0	0
MAS1L	116511	broad.mit.edu	37	6	29455089	29455089	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr6:29455089G>C	ENST00000377127.3	-	1	649	c.591C>G	c.(589-591)atC>atG	p.I197M		NM_052967.1	NP_443199.1	P35410	MAS1L_HUMAN	MAS1 oncogene-like	197						cytoplasm|integral to membrane|nucleus|plasma membrane	G-protein coupled receptor activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(7)|pancreas(1)|prostate(2)|skin(2)	28						GCAGGCCCCAGATGAGGGTGC	0.463000													17	90					0	0	0.004990	0	0
NBPF12	149013	broad.mit.edu	37	1	146465883	146465883	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr1:146465883A>G	ENST00000442909.2	+	82	10594	c.9758A>G	c.(9757-9759)aAc>aGc	p.N3253S	NBPF12_ENST00000446760.2_Missense_Mutation_p.T836A|NBPF12_ENST00000309471.8_Missense_Mutation_p.T788A					neuroblastoma breakpoint family, member 12											ovary(2)	2						TCCAGGCTCAACAGCGTGCTG	0.448000													4	137					0	0	0.000248	0	0
LRP5	4041	broad.mit.edu	37	11	68204361	68204361	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr11:68204361C>G	ENST00000294304.7	+	19	4111	c.4005C>G	c.(4003-4005)atC>atG	p.I1335M		NM_002335.2	NP_002326.2	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein 5	1335	LDL-receptor class A 3.				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			autonomic_ganglia(1)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(24)|ovary(5)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						TTGCAGCCATCTGCCTGCCCA	0.622000													17	68					0	0	0.004007	0	0
TDRD6	221400	broad.mit.edu	37	6	46660944	46660944	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr6:46660944G>C	ENST00000544460.1	+	1	5333	c.5079G>C	c.(5077-5079)gaG>gaC	p.E1693D	TDRD6_ENST00000316081.6_Missense_Mutation_p.E1693D	NM_001168359.1	NP_001161831.1	O60522	TDRD6_HUMAN	tudor domain containing 6	1693					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			NS(1)|breast(9)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80			Lung(136;0.192)			GTATTAATGAGAAAATGGAGA	0.333000													7	74					0	0	0.003080	0	0
BRD4	23476	broad.mit.edu	37	19	15349899	15349899	+	Silent	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr19:15349899C>T	ENST00000263377.2	-	18	3974	c.3753G>A	c.(3751-3753)gaG>gaA	p.E1251E		NM_058243.2	NP_490597.1	O60885	BRD4_HUMAN	bromodomain containing 4	1251					interspecies interaction between organisms|positive regulation of G2/M transition of mitotic cell cycle|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	condensed nuclear chromosome|cytoplasm	protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)|urinary_tract(1)	21			OV - Ovarian serous cystadenocarcinoma(3;3.02e-24)|Epithelial(3;4.71e-20)|all cancers(3;2.26e-18)			GCCGCTCCTTCTCCTTCTCAG	0.672000			T	C15orf55	lethal midline carcinoma of young people								9	24					0	0	0.006214	0	0
C10orf137	26098	broad.mit.edu	37	10	127442406	127442406	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr10:127442406G>C	ENST00000337623.3	+	23	3540	c.3435G>C	c.(3433-3435)aaG>aaC	p.K1145N	C10orf137_ENST00000356792.4_Missense_Mutation_p.K1179N	NM_015608.2	NP_056423.2	Q3B7T1	EDRF1_HUMAN	chromosome 10 open reading frame 137	1179					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(12)|lung(20)|ovary(8)|pancreas(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	61		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				CAACTAAAAAGAAAACAAGGT	0.348000													7	87					0	0	0.004482	0	0
COX11	1353	broad.mit.edu	37	17	53045777	53045777	+	Silent	SNP	C	C	G			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr17:53045777C>G	ENST00000299335.3	-	1	369	c.231G>C	c.(229-231)tcG>tcC	p.S77S	COX11_ENST00000571584.1_Silent_p.S77S	NM_004375.3	NP_004366.1	Q9Y6N1	COX11_HUMAN	cytochrome c oxidase assembly homolog 11 (yeast)	77					respiratory chain complex IV assembly|respiratory gaseous exchange	integral to membrane|mitochondrial inner membrane	copper ion binding|cytochrome-c oxidase activity|electron carrier activity			endometrium(1)|kidney(1)|large_intestine(1)|liver(2)|lung(2)|ovary(1)|prostate(1)	9						TGAAAGGGTTCGAGCTCTTAG	0.677000													17	141					0	0	0.006122	0	0
TNKS2	80351	broad.mit.edu	37	10	93615440	93615440	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr10:93615440C>T	ENST00000371627.4	+	23	3362	c.2983C>T	c.(2983-2985)Ctc>Ttc	p.L995F		NM_025235.3	NP_079511.1	Q9H2K2	TNKS2_HUMAN	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2	995	PARP catalytic.				positive regulation of canonical Wnt receptor signaling pathway|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein polyubiquitination|Wnt receptor signaling pathway	Golgi membrane|microsome|nuclear envelope|pericentriolar material|perinuclear region of cytoplasm	NAD+ ADP-ribosyltransferase activity|protein binding			biliary_tract(1)|breast(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(11)|lung(14)|ovary(1)|prostate(2)|skin(3)|urinary_tract(1)	48		Colorectal(252;0.162)				ATACAATATTCTCAAGGTAAT	0.368000													5	45					0	0	0.000602	0	0
ABCA12	26154	broad.mit.edu	37	2	215840688	215840688	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr2:215840688G>C	ENST00000272895.7	-	34	5421	c.5202C>G	c.(5200-5202)atC>atG	p.I1734M	ABCA12_ENST00000389661.4_Missense_Mutation_p.I1416M	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	1734					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		GGAACCTCTTGATGAGTATAG	0.478000													17	78					0	0	0.006122	0	0
NEURL4	84461	broad.mit.edu	37	17	7227283	7227283	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr17:7227283G>A	ENST00000399464.2	-	12	2126	c.2111C>T	c.(2110-2112)tCt>tTt	p.S704F	NEURL4_ENST00000570460.1_Missense_Mutation_p.S682F|NEURL4_ENST00000315614.7_Missense_Mutation_p.S704F	NM_032442.2	NP_115818.2			neuralized E3 ubiquitin protein ligase 4											central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						AGAGCTTGGAGACACCTGGTT	0.612000											OREG0024134	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	80					0	0	0.004482	0	0
CENPL	91687	broad.mit.edu	37	1	173772540	173772540	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr1:173772540G>A	ENST00000356198.2	-	6	947	c.662C>T	c.(661-663)tCa>tTa	p.S221L	CENPL_ENST00000345664.6_Missense_Mutation_p.S175L|CENPL_ENST00000367710.3_Missense_Mutation_p.S175L	NM_001127181.2	NP_001120653.1	Q8N0S6	CENPL_HUMAN	centromere protein L	175					mitotic prometaphase	chromosome, centromeric region|cytosol|nucleus				breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(3)	11						GAAATCTTCTGAAACAGTCTC	0.418000													30	147					0	0	0.002096	0	0
XIRP2	129446	broad.mit.edu	37	2	168103446	168103446	+	Silent	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr2:168103446C>T	ENST00000409195.1	+	9	5633	c.5544C>T	c.(5542-5544)ctC>ctT	p.L1848L	XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409273.1_Silent_p.L1626L|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000295237.9_Silent_p.L1848L|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000420519.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	1673					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						TAAATTCCCTCAGCCAGGCTG	0.378000													22	131					0	0	0.001523	0	0
PPP2R5D	5528	broad.mit.edu	37	6	42978733	42978733	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr6:42978733C>T	ENST00000485511.1	+	15	1848	c.1669C>T	c.(1669-1671)Cag>Tag	p.Q557*	PPP2R5D_ENST00000472118.1_Nonsense_Mutation_p.Q549*|PPP2R5D_ENST00000394110.3_Nonsense_Mutation_p.Q525*|PPP2R5D_ENST00000461010.1_Nonsense_Mutation_p.Q451*	NM_001270476.1|NM_006245.3	NP_001257405.1|NP_006236.1	Q14738	2A5D_HUMAN	protein phosphatase 2, regulatory subunit B', delta	557					nervous system development|signal transduction	cytoplasm|nucleus|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	25			Colorectal(64;0.00237)|all cancers(41;0.00411)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0664)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			TGAGGCTGTTCAGGTGGGAGG	0.547000													8	130					0	0	0.003080	0	0
FAM86C2P	645332	broad.mit.edu	37	11	67564228	67564228	+	RNA	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr11:67564228C>T	ENST00000528089.1	-	0	912																											GAGGAGCCCGCTGGTGCTCCC	0.627000													4	111					0	0	0.000248	0	0
ATRN	8455	broad.mit.edu	37	20	3571898	3571898	+	Silent	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr20:3571898C>T	ENST00000262919.5	+	19	3335	c.3267C>T	c.(3265-3267)tgC>tgT	p.C1089C	ATRN_ENST00000446916.2_Silent_p.C1089C	NM_139321.2	NP_647537.1	O75882	ATRN_HUMAN	attractin	1089	Laminin EGF-like 1.				inflammatory response	extracellular space|integral to plasma membrane	receptor activity|sugar binding			breast(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(22)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	59						GCAAGCACTGCGAGACCTGCA	0.478000													10	144					0	0	0.008291	0	0
DAPK1	1612	broad.mit.edu	37	9	90256923	90256923	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr9:90256923G>A	ENST00000469640.2	+	10	1243	c.868G>A	c.(868-870)Gca>Aca	p.A290T	DAPK1_ENST00000358077.5_Missense_Mutation_p.A290T|DAPK1_ENST00000491893.1_Missense_Mutation_p.A290T|DAPK1_ENST00000472284.1_Missense_Mutation_p.A290T|DAPK1_ENST00000408954.3_Missense_Mutation_p.A290T			P53355	DAPK1_HUMAN	death-associated protein kinase 1	290	Calmodulin-binding.				apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity	p.A290P(2)		breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(27)|liver(2)|lung(17)|ovary(1)|prostate(2)|skin(3)|stomach(1)	72						AAAAGCATCAGCAGTAAACAT	0.323000									Chronic Lymphocytic Leukemia, Familial Clustering of				15	76					0	0	0.006122	0	0
OR2AK2	391191	broad.mit.edu	37	1	248129018	248129018	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr1:248129018C>T	ENST00000366480.3	+	1	484	c.385C>T	c.(385-387)Ctc>Ttc	p.L129F	OR2L13_ENST00000366478.2_Intron	NM_001004491.1	NP_001004491.1	Q8NG84	O2AK2_HUMAN	olfactory receptor, family 2, subfamily AK, member 2	129					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(25)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	36	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			TGAAGCCCTTCTCCTTGGTTT	0.443000													64	376					0	0	0.003610	0	0
PDLIM2	64236	broad.mit.edu	37	8	22452129	22452129	+	Silent	SNP	G	G	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr8:22452129G>A	ENST00000265810.4	+	10	1183	c.1068G>A	c.(1066-1068)agG>agA	p.R356R	AC037459.4_ENST00000430850.2_Intron	NM_176871.3	NP_789847.1	Q96JY6	PDLI2_HUMAN	PDZ and LIM domain 2 (mystique)	0						actin cytoskeleton|cell surface|cytoplasm|focal adhesion|nucleus	zinc ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|urinary_tract(1)	9		Prostate(55;0.0421)|Breast(100;0.102)|all_epithelial(46;0.142)		BRCA - Breast invasive adenocarcinoma(99;0.00579)|Colorectal(74;0.0152)|COAD - Colon adenocarcinoma(73;0.0626)		GGGACAGGAGGAAGACCAGGA	0.612000													15	98					0	0	0.002450	0	0
HCG27	253018	broad.mit.edu	37	6	31170308	31170308	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr6:31170308G>C	ENST00000383331.4	+	2	283	c.283G>C	c.(283-285)Gac>Cac	p.D95H	HCG27_ENST00000415276.1_3'UTR																							AGGGAGATGAGACATACCAGG	0.632000													4	26					0	0	0.000248	0	0
PVRL1	5818	broad.mit.edu	37	11	119535534	119535534	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr11:119535534C>G	ENST00000264025.3	-	6	2007	c.1477G>C	c.(1477-1479)Gag>Cag	p.E493Q	PVRL1_ENST00000341398.2_Intron	NM_002855.4	NP_002846.3	Q15223	PVRL1_HUMAN	poliovirus receptor-related 1 (herpesvirus entry mediator C)	493					adherens junction organization|cell junction assembly|entry of virus into host cell|heterophilic cell-cell adhesion|homophilic cell adhesion|immune response	cell-cell adherens junction|extracellular region|integral to membrane	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(9)|liver(1)|lung(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		Breast(348;0.037)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.29e-05)		TCCAGCTGCTCAGGGTCGTAC	0.592000													9	46					0	0	0.006214	0	0
RBM14	10432	broad.mit.edu	37	11	66392624	66392624	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr11:66392624C>G	ENST00000310137.4	+	2	1416	c.1277C>G	c.(1276-1278)tCt>tGt	p.S426C	RBM14-RBM4_ENST00000511114.1_Intron|RBM14_ENST00000409738.4_Intron|RBM14-RBM4_ENST00000412278.2_Intron|RBM4_ENST00000503028.2_Intron|RBM14_ENST00000393979.3_Intron|RBM14-RBM4_ENST00000500635.2_Intron|RBM4_ENST00000514361.3_Intron	NM_006328.3	NP_006319.1	Q96PK6	RBM14_HUMAN	RNA binding motif protein 14	426	Ala-rich.				DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|histone deacetylation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus	mediator complex|ribonucleoprotein complex|transcription factor complex	ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|protein binding, bridging|RNA binding|RNA polymerase II transcription cofactor activity		RBM14/PACS1(2)	breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(3)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	17						GCTTCCTACTCTTCCCAACCT	0.602000													45	287					0	0	0.002852	0	0
ITGB4	3691	broad.mit.edu	37	17	73726984	73726984	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr17:73726984C>T	ENST00000200181.3	+	9	1218	c.1031C>T	c.(1030-1032)tCa>tTa	p.S344L	ITGB4_ENST00000449880.2_Missense_Mutation_p.S344L|ITGB4_ENST00000339591.3_Missense_Mutation_p.S344L|ITGB4_ENST00000579662.1_Missense_Mutation_p.S344L|ITGB4_ENST00000450894.3_Missense_Mutation_p.S344L|ITGB4_ENST00000584558.1_3'UTR	NM_000213.3	NP_000204.3	P16144	ITB4_HUMAN	integrin, beta 4	344					cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|liver(1)|lung(25)|skin(1)|urinary_tract(1)	43	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			CCTGTCTCCTCACTGGGGGTG	0.567000													56	236					0	0	0.003610	0	0
RAP1GAP	5909	broad.mit.edu	37	1	21929365	21929365	+	Silent	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr1:21929365C>T	ENST00000542643.2	-	21	1850	c.1548G>A	c.(1546-1548)tcG>tcA	p.S516S	RAP1GAP_ENST00000374761.2_Silent_p.S521S|RAP1GAP_ENST00000374763.2_Silent_p.S575S|RAP1GAP_ENST00000290101.4_Silent_p.S554S|RAP1GAP_ENST00000374765.4_Silent_p.S490S	NM_001145657.1	NP_001139129.1	P47736	RPGP1_HUMAN	RAP1 GTPase activating protein	490					regulation of Ras GTPase activity|signal transduction	cytosol|Golgi membrane|membrane fraction	GTPase activator activity|GTPase activity|protein homodimerization activity|Ras GTPase binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(7)|ovary(2)|skin(1)	17		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.000861)|all_lung(284;0.000901)|Breast(348;0.012)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0192)|OV - Ovarian serous cystadenocarcinoma(117;2.3e-26)|COAD - Colon adenocarcinoma(152;1.59e-05)|GBM - Glioblastoma multiforme(114;2.7e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000354)|STAD - Stomach adenocarcinoma(196;0.00645)|KIRC - Kidney renal clear cell carcinoma(1967;0.00862)|READ - Rectum adenocarcinoma(331;0.0625)|Lung(427;0.146)		CGAACGGGCCCGACTTCTTCC	0.652000													4	45					0	0	0.000248	0	0
RHOB	388	broad.mit.edu	37	2	20647480	20647480	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr2:20647480C>T	ENST00000272233.4	+	1	646	c.254C>T	c.(253-255)tCg>tTg	p.S85L		NM_004040.2	NP_004031.1	P62745	RHOB_HUMAN	ras homolog family member B	85					angiogenesis|axon guidance|cell adhesion|endosome to lysosome transport|negative regulation of cell cycle|platelet activation|positive regulation of angiogenesis|protein transport|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|transformed cell apoptosis	cytosol|late endosome membrane|nucleus|plasma membrane	GTP binding|GTPase activity|protein binding			breast(1)|kidney(1)|lung(2)|ovary(1)|urinary_tract(2)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)	all_epithelial(98;4.19e-09)|Lung NSC(108;0.00452)|Ovarian(717;0.0164)		OV - Ovarian serous cystadenocarcinoma(76;1.14e-22)|Epithelial(75;7.84e-19)		ATGTGCTTCTCGGTGGACAGC	0.637000													18	192					0	0	0.006122	0	0
PTPN22	26191	broad.mit.edu	37	1	114391204	114391204	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr1:114391204C>G	ENST00000359785.5	-	11	1008	c.873G>C	c.(871-873)aaG>aaC	p.K291N	PTPN22_ENST00000525799.1_Missense_Mutation_p.K164N|PTPN22_ENST00000460620.1_Intron|PTPN22_ENST00000528414.1_Intron|PTPN22_ENST00000420377.2_Missense_Mutation_p.K291N|PTPN22_ENST00000538253.1_Missense_Mutation_p.K47N	NM_001193431.1|NM_015967.5	NP_001180360.1|NP_057051	Q9Y2R2	PTN22_HUMAN	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	291					negative regulation of T cell activation|negative regulation of T cell receptor signaling pathway|phosphoanandamide dephosphorylation|regulation of B cell receptor signaling pathway|regulation of natural killer cell proliferation|T cell differentiation	internal side of plasma membrane|nucleus|perinuclear region of cytoplasm	kinase binding|protein tyrosine phosphatase activity|SH3 domain binding			NS(1)|breast(1)|kidney(3)|large_intestine(4)|lung(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	21	Lung SC(450;0.184)	all_cancers(81;1.93e-08)|all_epithelial(167;4.37e-08)|all_lung(203;5.22e-06)|Lung NSC(69;8.94e-06)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CCATCTGTCTCTTAAATAGTT	0.313000													34	213					0	0	0.004289	0	0
TAF1D	79101	broad.mit.edu	37	11	93471479	93471479	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr11:93471479C>G	ENST00000448108.2	-	3	905	c.255G>C	c.(253-255)aaG>aaC	p.K85N		NM_024116.3	NP_077021.1	Q9H5J8	TAF1D_HUMAN	TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa	85					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			large_intestine(1)|lung(3)|prostate(1)|skin(2)	7						TTTTCCTGTTCTTGAATCTTT	0.378000													32	146					0	0	0.008361	0	0
SEPT11	55752	broad.mit.edu	37	4	77941657	77941657	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr4:77941657G>C	ENST00000264893.6	+	7	988	c.787G>C	c.(787-789)Gag>Cag	p.E263Q	SEPT11_ENST00000505788.1_Missense_Mutation_p.E263Q|SEPT11_ENST00000541121.1_Missense_Mutation_p.E273Q|SEPT11_ENST00000512575.1_Intron|SEPT11_ENST00000510515.1_Missense_Mutation_p.E273Q|SEPT11_ENST00000502584.1_Missense_Mutation_p.E263Q	NM_018243.2	NP_060713.1	Q9NVA2	SEP11_HUMAN	septin 11	263					cell cycle|cell division|protein heterooligomerization	axon|cell junction|dendritic spine|septin complex|stress fiber|synapse	GTP binding|protein binding			endometrium(2)|kidney(3)|large_intestine(3)|lung(1)|skin(1)|stomach(1)	11						TCTTGTAGTTGAGAATGAAAA	0.453000													18	108					0	0	0.008871	0	0
ZNF333	84449	broad.mit.edu	37	19	14805830	14805830	+	Silent	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr19:14805830C>T	ENST00000292530.6	+	3	103	c.12C>T	c.(10-12)gtC>gtT	p.V4V	ZNF333_ENST00000536363.1_5'UTR|ZNF333_ENST00000540689.2_Silent_p.V4V|ZNF333_ENST00000601134.1_Silent_p.V4V|ZNF333_ENST00000601629.1_3'UTR	NM_032433.2	NP_115809.1	Q96JL9	ZN333_HUMAN	zinc finger protein 333	4	KRAB 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(5)|ovary(2)|pancreas(1)|prostate(1)	21						AGGAATCCGTCACCTTTGAGG	0.527000													28	118					0	0	0.007291	0	0
MGAM	8972	broad.mit.edu	37	7	141763322	141763322	+	Silent	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr7:141763322C>T	ENST00000475668.2	+	36	4335	c.4281C>T	c.(4279-4281)ttC>ttT	p.F1427F	MGAM_ENST00000549489.2_Silent_p.F1427F			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	1427	Glucoamylase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CATCAAGCTTCGTGAATGGGG	0.493000													6	29					0	0	0.001984	0	0
TCOF1	6949	broad.mit.edu	37	5	149758948	149758948	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr5:149758948G>A	ENST00000451292.1	+	16	2743	c.2635G>A	c.(2635-2637)Gag>Aag	p.E879K	TCOF1_ENST00000506063.1_3'UTR|TCOF1_ENST00000513346.1_Missense_Mutation_p.E879K|TCOF1_ENST00000439160.2_Missense_Mutation_p.E879K|TCOF1_ENST00000504761.2_Missense_Mutation_p.E879K|TCOF1_ENST00000323668.7_Missense_Mutation_p.E802K|TCOF1_ENST00000377797.3_Missense_Mutation_p.E879K|TCOF1_ENST00000445265.2_Missense_Mutation_p.E802K|TCOF1_ENST00000394269.3_Missense_Mutation_p.E879K			Q13428	TCOF_HUMAN	Treacher Collins-Franceschetti syndrome 1	879					skeletal system development	nucleolus	protein binding|transporter activity			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(8)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	35		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGACAGTGAGGAGGAGGCGGA	0.597000													19	73					0	0	0.006122	0	0
SLC6A9	6536	broad.mit.edu	37	1	44467181	44467181	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr1:44467181C>A	ENST00000372310.3	-	9	1246	c.1081G>T	c.(1081-1083)Gac>Tac	p.D361Y	SLC6A9_ENST00000372306.3_Missense_Mutation_p.D361Y|SLC6A9_ENST00000372307.3_Missense_Mutation_p.D296Y|SLC6A9_ENST00000475075.2_Missense_Mutation_p.D250Y|SLC6A9_ENST00000360584.2_Missense_Mutation_p.D434Y|SLC6A9_ENST00000357730.2_Missense_Mutation_p.D380Y|SLC6A9_ENST00000537678.1_Missense_Mutation_p.D296Y	NM_001024845.2	NP_001020016.1	P48067	SC6A9_HUMAN	solute carrier family 6 (neurotransmitter transporter, glycine), member 9	434						integral to plasma membrane|membrane fraction	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			endometrium(3)|large_intestine(8)|lung(7)|ovary(1)|skin(1)|urinary_tract(2)	22	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)			Glycine(DB00145)	GGGCCGTGGTCTGCCACACGG	0.592000													26	130					4.26978e-12	8.34162e-12	0.003330	1	0
DTX1	1840	broad.mit.edu	37	12	113515335	113515335	+	Missense_Mutation	SNP	T	T	G			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr12:113515335T>G	ENST00000257600.3	+	2	869	c.366T>G	c.(364-366)gaT>gaG	p.D122E		NM_004416.2	NP_004407.2	Q86Y01	DTX1_HUMAN	deltex homolog 1 (Drosophila)	122	WWE 2.				negative regulation of neuron differentiation|Notch signaling pathway|regulation of Notch signaling pathway|transcription from RNA polymerase II promoter	cytoplasm|nucleus	Notch binding|SH3 domain binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(11)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	32						CGGCCTACGATATGGACATCT	0.622000													7	210					0	0	0.003080	0	0
RNLS	55328	broad.mit.edu	37	10	90122330	90122330	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr10:90122330C>T	ENST00000371947.3	-	5	2018	c.679G>A	c.(679-681)Gat>Aat	p.D227N	RNLS_ENST00000466945.1_5'UTR|RNLS_ENST00000437752.1_Missense_Mutation_p.D144N|RNLS_ENST00000331772.4_Missense_Mutation_p.D227N	NM_018363.3	NP_060833.1	Q5VYX0	RNLS_HUMAN	renalase, FAD-dependent amine oxidase	227						extracellular region	oxidoreductase activity			breast(1)|kidney(1)|lung(3)|ovary(1)|prostate(1)	7						TTCTTATTATCAATGGAGACG	0.423000													23	113					0	0	0.003954	0	0
ELF3	1999	broad.mit.edu	37	1	201982329	201982329	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr1:201982329G>C	ENST00000359651.3	+	6	3900	c.708G>C	c.(706-708)aaG>aaC	p.K236N	ELF3_ENST00000367284.5_Missense_Mutation_p.K236N|RP11-510N19.5_ENST00000504773.1_RNA|ELF3_ENST00000367283.3_Missense_Mutation_p.K236N			P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription factor, epithelial-specific )	236					epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(2)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	20						GTGACTGCAAGAAGGGGGATC	0.592000													15	76					0	0	0.003163	0	0
STAG1	10274	broad.mit.edu	37	3	136192462	136192462	+	Silent	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr3:136192462C>T	ENST00000383202.2	-	11	1300	c.1044G>A	c.(1042-1044)ctG>ctA	p.L348L	STAG1_ENST00000236698.5_Silent_p.L348L|STAG1_ENST00000434713.2_Silent_p.L122L	NM_005862.2	NP_005853.2	Q8WVM7	STAG1_HUMAN	stromal antigen 1	348	SCD.				cell division|chromosome segregation|mitotic metaphase/anaphase transition|mitotic prometaphase	cell junction|chromatin|chromosome, centromeric region|nucleoplasm	protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(16)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58						TCAAACACTTCAGCCTGACTT	0.348000													14	92					0	0	0.001855	0	0
MICAL2	9645	broad.mit.edu	37	11	12225944	12225944	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr11:12225944C>T	ENST00000256194.4	+	4	700	c.412C>T	c.(412-414)Cgt>Tgt	p.R138C	MICAL2_ENST00000527195.1_3'UTR|MICAL2_ENST00000342902.5_Missense_Mutation_p.R138C|MICAL2_ENST00000537344.1_Missense_Mutation_p.R138C|MICAL2_ENST00000379612.3_Missense_Mutation_p.R138C|MICAL2_ENST00000527546.1_Missense_Mutation_p.R138C	NM_001282663.1|NM_014632.2	NP_001269592.1|NP_055447.1	O94851	MICA2_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 2	138						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(12)|ovary(2)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	47				Epithelial(150;0.00552)		CCATGACCTTCGTGGCCTGGG	0.547000													23	135					0	0	0.002299	0	0
C11orf73	51501	broad.mit.edu	37	11	86017314	86017314	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr11:86017314G>A	ENST00000533986.1	+	2	296	c.58G>A	c.(58-60)Gag>Aag	p.E20K	C11orf73_ENST00000278483.3_Missense_Mutation_p.E20K|C11orf73_ENST00000530208.1_3'UTR			Q53FT3	CK073_HUMAN	chromosome 11 open reading frame 73	20						cytoplasm				kidney(1)|large_intestine(1)|urinary_tract(1)	3		Acute lymphoblastic leukemia(157;1.17e-07)|all_hematologic(158;0.000556)				GCAAGTGGCAGAGGATAAATT	0.373000													19	95					0	0	0.008871	0	0
MICAL1	64780	broad.mit.edu	37	6	109771575	109771575	+	Silent	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr6:109771575C>T	ENST00000368952.4	-	8	1466	c.1176G>A	c.(1174-1176)gaG>gaA	p.E392E	MICAL1_ENST00000358577.3_Intron|MICAL1_ENST00000358807.3_Silent_p.E373E			Q8TDZ2	MICA1_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 1	373					cytoskeleton organization|signal transduction	cytoplasm|intermediate filament	SH3 domain binding|zinc ion binding			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|liver(1)|lung(7)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	40		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0142)|all cancers(137;0.0197)|OV - Ovarian serous cystadenocarcinoma(136;0.0233)|BRCA - Breast invasive adenocarcinoma(108;0.0574)		GAGCAGAACTCTCTGCCCGCA	0.607000													11	133					0	0	0.008291	0	0
HCG27	253018	broad.mit.edu	37	6	31170271	31170271	+	Silent	SNP	G	G	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr6:31170271G>C	ENST00000383331.4	+	2	246	c.246G>C	c.(244-246)cgG>cgC	p.R82R	HCG27_ENST00000415276.1_3'UTR																							GCCAACCCCGGACTCAAGACT	0.612000													3	18					0	0	0.004672	0	0
KCNS1	3787	broad.mit.edu	37	20	43723900	43723900	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr20:43723900C>T	ENST00000306117.1	-	5	1588	c.1192G>A	c.(1192-1194)Gaa>Aaa	p.E398K	KCNS1_ENST00000537075.1_Missense_Mutation_p.E398K	NM_002251.3	NP_002242.2	Q96KK3	KCNS1_HUMAN	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1	398						voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium channel regulator activity|protein binding			endometrium(1)|lung(3)|ovary(1)|stomach(1)	6		Myeloproliferative disorder(115;0.0122)				TCCTCCTTTTCAGCTGTGTAG	0.567000													6	72					0	0	0.001168	0	0
KMT2A	4297	broad.mit.edu	37	11	118373897	118373897	+	Silent	SNP	G	G	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr11:118373897G>A	ENST00000534358.1	+	27	7313	c.7290G>A	c.(7288-7290)caG>caA	p.Q2430Q	KMT2A_ENST00000389506.5_Silent_p.Q2427Q|KMT2A_ENST00000354520.4_Silent_p.Q2389Q	NM_001197104.1|NM_005933.3	NP_001184033.1|NP_005924.2			lysine (K)-specific methyltransferase 2A																		ATAGGAGACAGAAAGGGAAAA	0.383000													13	70					0	0	0.001368	0	0
TEKT1	83659	broad.mit.edu	37	17	6733599	6733599	+	Nonsense_Mutation	SNP	G	G	A	rs143066578		TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr17:6733599G>A	ENST00000338694.2	-	2	226	c.97C>T	c.(97-99)Cga>Tga	p.R33*	TEKT1_ENST00000535086.1_5'UTR	NM_053285.1	NP_444515.1	Q969V4	TEKT1_HUMAN	tektin 1	33					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule		p.R33*(1)|p.R33G(1)		NS(1)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(1)|stomach(1)	20		Myeloproliferative disorder(207;0.0255)				CGTTCTGATCGGGACCTTTGA	0.468000													22	72					0	0	0.001882	0	0
DNAJC9	23234	broad.mit.edu	37	10	75005705	75005705	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr10:75005705T>C	ENST00000372950.4	-	3	2223	c.551A>G	c.(550-552)cAa>cGa	p.Q184R		NM_015190.3	NP_056005.1	Q8WXX5	DNJC9_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 9	184					protein folding		heat shock protein binding|unfolded protein binding			endometrium(2)|kidney(1)|large_intestine(2)|stomach(1)	6	Prostate(51;0.0119)					ATTCATCTTTTGTTTCGATTC	0.393000													17	116					0	0	0.004007	0	0
DLD	1738	broad.mit.edu	37	7	107558422	107558422	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr7:107558422G>C	ENST00000205402.5	+	12	1571	c.1290G>C	c.(1288-1290)aaG>aaC	p.K430N	DLD_ENST00000437604.2_Missense_Mutation_p.K382N|DLD_ENST00000440410.1_Missense_Mutation_p.K407N|DLD_ENST00000537148.1_Missense_Mutation_p.K331N	NM_000108.3	NP_000099.2	P09622	DLDH_HUMAN	dihydrolipoamide dehydrogenase	430					branched chain family amino acid catabolic process|cell redox homeostasis|lysine catabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate|tricarboxylic acid cycle	mitochondrial matrix	dihydrolipoyl dehydrogenase activity			NS(1)|breast(1)|central_nervous_system(1)|kidney(5)|large_intestine(1)|lung(10)|prostate(1)	20					NADH(DB00157)	GCAGAGCTAAGACAAATGCTG	0.428000													23	117					0	0	0.003330	0	0
TCHP	84260	broad.mit.edu	37	12	110345342	110345342	+	Silent	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr12:110345342C>T	ENST00000312777.5	+	6	751	c.537C>T	c.(535-537)acC>acT	p.T179T	TCHP_ENST00000405876.4_Silent_p.T179T	NM_032300.4	NP_115676.1	Q9BT92	TCHP_HUMAN	trichoplein, keratin filament binding	179	Glu-rich.|Interaction with keratin proteins.				apoptosis|negative regulation of cell growth	apical cortex|centrosome|keratin filament|mitochondrion|plasma membrane	protein binding			NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|ovary(1)|skin(2)	22						AAGAAGCCACCGCAGAGCAAG	0.517000													24	202					0	0	0.002780	0	0
SRRM2	23524	broad.mit.edu	37	16	2817533	2817533	+	Missense_Mutation	SNP	C	C	G	rs140636308		TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr16:2817533C>G	ENST00000301740.8	+	11	7553	c.7004C>G	c.(7003-7005)tCt>tGt	p.S2335C	SRRM2_ENST00000574593.1_3'UTR	NM_016333.3	NP_057417.3	Q9UQ35	SRRM2_HUMAN	serine/arginine repetitive matrix 2	2335	Ala-rich.|Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|lung(34)|ovary(6)|pancreas(3)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(7)	105						GCTCCAGCCTCTGCAAACCTG	0.622000													65	445					0	0	0.003610	0	0
KRTAP1-1	81851	broad.mit.edu	37	17	39197549	39197549	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr17:39197549G>C	ENST00000306271.4	-	1	164	c.101C>G	c.(100-102)tCc>tGc	p.S34C		NM_030967.2	NP_112229.1	Q07627	KRA11_HUMAN	keratin associated protein 1-1	34			Missing (in allele KAP1.7).|PSCSTSGTCGSSCCQPSCCETSSCQPRCCETSCCQPSCCQT SFCGFP -> R (in allele KAP1.6).			extracellular region|keratin filament		p.S34C(6)		NS(2)|endometrium(2)|kidney(5)|lung(4)|prostate(1)	14		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			TGGCTGGCAGGAGCTGGTCTC	0.612000													4	208					0	0	0.001168	0	0
SH2B3	10019	broad.mit.edu	37	12	111885521	111885521	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr12:111885521C>T	ENST00000341259.2	+	7	1655	c.1298C>T	c.(1297-1299)tCg>tTg	p.S433L	SH2B3_ENST00000538307.1_Missense_Mutation_p.S231L	NM_005475.2	NP_005466.1	Q9UQQ2	SH2B3_HUMAN	SH2B adaptor protein 3	433	SH2.				blood coagulation	cytosol	signal transducer activity			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(2)|ovary(1)|skin(1)	10						CACTTTCCCTCGGTCGTGGAC	0.667000													14	221					0	0	0.002450	0	0
PPP2R5D	5528	broad.mit.edu	37	6	42979021	42979021	+	Silent	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr6:42979021C>T	ENST00000485511.1	+	16	1985	c.1806C>T	c.(1804-1806)ctC>ctT	p.L602L	PPP2R5D_ENST00000472118.1_Silent_p.L594L|PPP2R5D_ENST00000394110.3_Silent_p.L570L|PPP2R5D_ENST00000461010.1_Silent_p.L496L	NM_001270476.1|NM_006245.3	NP_001257405.1|NP_006236.1	Q14738	2A5D_HUMAN	protein phosphatase 2, regulatory subunit B', delta	602					nervous system development|signal transduction	cytoplasm|nucleus|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	25			Colorectal(64;0.00237)|all cancers(41;0.00411)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0664)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			AGGAGGCTCTCTGACCCCTCA	0.637000													4	67					0	0	0.000602	0	0
COL14A1	7373	broad.mit.edu	37	8	121219293	121219293	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr8:121219293G>A	ENST00000297848.3	+	10	1421	c.1151G>A	c.(1150-1152)aGa>aAa	p.R384K	COL14A1_ENST00000309791.4_Missense_Mutation_p.R384K|COL14A1_ENST00000432943.2_3'UTR|COL14A1_ENST00000247781.3_Missense_Mutation_p.R289K|COL14A1_ENST00000537875.1_Missense_Mutation_p.R384K	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	384	Fibronectin type-III 2.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			GAAAAATACAGAGTTGTGTAT	0.428000													6	34					0	0	0.001168	0	0
CHD6	84181	broad.mit.edu	37	20	40083271	40083271	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr20:40083271C>T	ENST00000373233.3	-	20	3292	c.3115G>A	c.(3115-3117)Gaa>Aaa	p.E1039K	CHD6_ENST00000309279.7_Intron	NM_032221.3	NP_115597.3	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	1039					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(24)|lung(53)|ovary(8)|prostate(5)|skin(8)|stomach(1)|urinary_tract(9)	129		Myeloproliferative disorder(115;0.00425)				TGTACCTTTTCATTCTTTGCT	0.343000													26	140					0	0	0.006320	0	0
MSI2	124540	broad.mit.edu	37	17	55334425	55334425	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr17:55334425C>T	ENST00000322684.3	+	1	52	c.17C>T	c.(16-18)tCg>tTg	p.S6L	MSI2_ENST00000416426.2_Intron|MSI2_ENST00000284073.2_Intron	NM_170721.1	NP_733839.1	Q96DH6	MSI2H_HUMAN	musashi RNA-binding protein 2	0						cytoplasm	nucleotide binding|RNA binding			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|ovary(1)|pancreas(1)|skin(1)	7	Breast(9;1.78e-08)			GBM - Glioblastoma multiforme(1;0.0025)		GATCTGACATCGGTGCTCACT	0.557000			T	HOXA9	CML								6	61					0	0	0.003080	0	0
METTL3	56339	broad.mit.edu	37	14	21972010	21972010	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr14:21972010C>T	ENST00000298717.4	-	2	266	c.115G>A	c.(115-117)Gag>Aag	p.E39K	METTL3_ENST00000538267.1_Missense_Mutation_p.E39K	NM_019852.3	NP_062826.2	Q86U44	MTA70_HUMAN	methyltransferase like 3	39					gene expression	nuclear speck	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity|RNA binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|pancreas(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	20	all_cancers(95;0.000628)		Epithelial(56;6.61e-06)	GBM - Glioblastoma multiforme(265;0.0146)		AATGCTGCCTCTGGATTCCGT	0.468000													8	116					0	0	0.003080	0	0
PPP1R14B	26472	broad.mit.edu	37	11	64012289	64012289	+	Silent	SNP	G	G	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr11:64012289G>A	ENST00000309318.3	-	4	648	c.381C>T	c.(379-381)ttC>ttT	p.F127F	PPP1R14B_ENST00000392210.2_Silent_p.F25F|PPP1R14B_ENST00000542235.1_Silent_p.F52F	NM_138689.2	NP_619634.1	Q96C90	PP14B_HUMAN	protein phosphatase 1, regulatory (inhibitor) subunit 14B	127					regulation of phosphorylation	cytoplasm	protein phosphatase inhibitor activity			kidney(1)|lung(1)|pancreas(1)	3						GGCCAGAAATGAAGGCCTGGA	0.637000													17	72					0	0	0.004990	0	0
CDK5RAP1	51654	broad.mit.edu	37	20	31948225	31948225	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr20:31948225C>G	ENST00000357886.4	-	14	1810	c.1657G>C	c.(1657-1659)Gag>Cag	p.E553Q	CDK5RAP1_ENST00000346416.2_Missense_Mutation_p.E539Q|CDK5RAP1_ENST00000544843.1_3'UTR|CDK5RAP1_ENST00000473997.1_Missense_Mutation_p.E449Q|CDK5RAP1_ENST00000339269.5_Missense_Mutation_p.E462Q			Q96SZ6	CK5P1_HUMAN	CDK5 regulatory subunit associated protein 1	553	CDK5R1-binding.|TRAM.				brain development|negative regulation of cyclin-dependent protein kinase activity|regulation of neuron differentiation|tRNA modification	cytoplasm	4 iron, 4 sulfur cluster binding|metal ion binding|neuronal Cdc2-like kinase binding|transferase activity			endometrium(2)|kidney(2)|large_intestine(3)|lung(12)|ovary(3)|skin(3)|urinary_tract(1)	26						TCCTCCATCTCTGCATCAGGG	0.527000													5	84					0	0	0.000602	0	0
STK32A	202374	broad.mit.edu	37	5	146730683	146730683	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr5:146730683G>T	ENST00000397936.3	+	7	861	c.528G>T	c.(526-528)caG>caT	p.Q176H	STK32A_ENST00000398523.3_Missense_Mutation_p.Q176H	NM_001112724.1	NP_001106195.1	Q8WU08	ST32A_HUMAN	serine/threonine kinase 32A	176	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(7)|prostate(1)|skin(1)	13			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGAGACACAGATTACCACCA	0.448000													8	36					0.000157383	0.00029572	0.003080	1	0
MGA	23269	broad.mit.edu	37	15	42042124	42042124	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr15:42042124C>G	ENST00000219905.7	+	17	6500	c.6319C>G	c.(6319-6321)Caa>Gaa	p.Q2107E	MGA_ENST00000570161.1_Missense_Mutation_p.Q2107E|MGA_ENST00000566586.1_Missense_Mutation_p.Q1898E|MGA_ENST00000389936.4_Missense_Mutation_p.Q2068E|MGA_ENST00000545763.1_Missense_Mutation_p.Q1898E	NM_001164273.1	NP_001157745.1	Q8IWI9	MGAP_HUMAN	MGA, MAX dimerization protein	2068						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(33)|ovary(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		AGTACAGCATCAAAAACTTGG	0.363000													15	49					0	0	0.002450	0	0
ARHGAP29	9411	broad.mit.edu	37	1	94671205	94671205	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr1:94671205G>A	ENST00000260526.6	-	6	727	c.545C>T	c.(544-546)tCa>tTa	p.S182L	ARHGAP29_ENST00000370217.3_Missense_Mutation_p.S182L	NM_004815.3	NP_004806.3	Q52LW3	RHG29_HUMAN	Rho GTPase activating protein 29	182					Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			NS(1)|breast(5)|endometrium(6)|kidney(2)|large_intestine(9)|lung(19)|ovary(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		TTCACTGGATGAGTCCACTGA	0.313000													7	93					0	0	0.004482	0	0
EXPH5	23086	broad.mit.edu	37	11	108409778	108409778	+	Nonsense_Mutation	SNP	G	G	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr11:108409778G>C	ENST00000265843.4	-	3	526	c.416C>G	c.(415-417)tCa>tGa	p.S139*	EXPH5_ENST00000525344.1_Nonsense_Mutation_p.S132*|EXPH5_ENST00000428840.1_Nonsense_Mutation_p.S63*	NM_015065.2	NP_055880	Q149M6	Q149M6_HUMAN	exophilin 5	139					intracellular protein transport		Rab GTPase binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(13)|liver(1)|lung(34)|ovary(3)|pancreas(2)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(1)	91		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		TGGAAGCTTTGAAGTCTCCTT	0.448000													23	161					0	0	0.002780	0	0
POLD3	10714	broad.mit.edu	37	11	74340326	74340326	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr11:74340326A>G	ENST00000263681.2	+	9	1093	c.964A>G	c.(964-966)Aga>Gga	p.R322G	POLD3_ENST00000532497.1_Missense_Mutation_p.R216G|POLD3_ENST00000527458.1_Missense_Mutation_p.R283G	NM_006591.2	NP_006582.1	Q15054	DPOD3_HUMAN	polymerase (DNA-directed), delta 3, accessory subunit	322					base-excision repair|DNA strand elongation involved in DNA replication|DNA synthesis involved in DNA repair|mismatch repair|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	delta DNA polymerase complex|nucleoplasm	DNA-directed DNA polymerase activity|protein binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)|skin(1)|stomach(1)	18	Breast(11;3.21e-06)					GAAAAAGAGGAGAAGAATCAA	0.398000													26	104					0	0	0.005443	0	0
PHLDB2	90102	broad.mit.edu	37	3	111681118	111681118	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr3:111681118G>T	ENST00000431670.2	+	13	3447	c.3036G>T	c.(3034-3036)atG>atT	p.M1012I	PHLDB2_ENST00000481953.1_Missense_Mutation_p.M969I|PHLDB2_ENST00000470699.2_3'UTR|PHLDB2_ENST00000495180.1_Missense_Mutation_p.M503I|PHLDB2_ENST00000393923.3_Missense_Mutation_p.M996I|PHLDB2_ENST00000412622.1_Missense_Mutation_p.M969I|PHLDB2_ENST00000393925.3_Missense_Mutation_p.M1012I	NM_001134438.1	NP_001127910.1	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B, member 2	1012						cytoplasm|intermediate filament cytoskeleton|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(7)|large_intestine(8)|lung(23)|ovary(6)|skin(7)|stomach(1)	55						CTGATAGCATGGAGACCAGCA	0.423000													19	100					5.35267e-07	1.02869e-06	0.007413	1	0
MUC16	94025	broad.mit.edu	37	19	9048498	9048498	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr19:9048498G>C	ENST00000397910.4	-	5	33336	c.33133C>G	c.(33133-33135)Ctg>Gtg	p.L11045V		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	11047	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CTAGTGACCAGAGAGGTCACC	0.493000													14	120					0	0	0.001855	0	0
GOLIM4	27333	broad.mit.edu	37	3	167747602	167747602	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr3:167747602C>G	ENST00000470487.1	-	10	2088	c.1399G>C	c.(1399-1401)Gag>Cag	p.E467Q	GOLIM4_ENST00000309027.4_Missense_Mutation_p.E439Q	NM_014498.3	NP_055313.1	O00461	GOLI4_HUMAN	golgi integral membrane protein 4	467	Gln-rich.|Glu-rich.				transport	cis-Golgi network|endocytic vesicle|endosome membrane|Golgi cisterna membrane|Golgi lumen|integral to membrane|nucleus				breast(5)|endometrium(2)|large_intestine(8)|lung(26)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47						CGGCCCTCCTCAAGCTCAGCC	0.582000													14	64					0	0	0.002450	0	0
RRN3P2	653390	broad.mit.edu	37	16	29110458	29110458	+	RNA	SNP	T	T	C	rs151074589	by1000genomes	TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr16:29110458T>C	ENST00000564580.1	+	0	1131																		p.W375R(25)									GAATTTTGAGTGGATAGTGAT	0.328000													5	47					0	0	0.000602	0	0
PPP2R5D	5528	broad.mit.edu	37	6	42975942	42975942	+	Silent	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr6:42975942C>T	ENST00000485511.1	+	8	1040	c.861C>T	c.(859-861)ttC>ttT	p.F287F	PPP2R5D_ENST00000472118.1_Silent_p.F279F|PPP2R5D_ENST00000394110.3_Silent_p.F255F|PPP2R5D_ENST00000461010.1_Silent_p.F181F	NM_001270476.1|NM_006245.3	NP_001257405.1|NP_006236.1	Q14738	2A5D_HUMAN	protein phosphatase 2, regulatory subunit B', delta	287					nervous system development|signal transduction	cytoplasm|nucleus|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	25			Colorectal(64;0.00237)|all cancers(41;0.00411)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0664)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			CCCTCAGGTTCATCTACGAGA	0.582000													19	228					0	0	0.007413	0	0
EZR	7430	broad.mit.edu	37	6	159204664	159204664	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr6:159204664G>T	ENST00000367075.3	-	7	754	c.586C>A	c.(586-588)Cag>Aag	p.Q196K	EZR_ENST00000337147.7_Missense_Mutation_p.Q196K|EZR_ENST00000392177.4_Missense_Mutation_p.Q164K|EZR_ENST00000476189.1_5'UTR	NM_001111077.1	NP_001104547.1	P15311	EZRI_HUMAN	ezrin	196	FERM.				actin filament bundle assembly|axon guidance|cytoskeletal anchoring at plasma membrane|leukocyte cell-cell adhesion|membrane to membrane docking|regulation of cell shape	actin filament|apical plasma membrane|basolateral plasma membrane|cortical cytoskeleton|cytosol|extrinsic to membrane|filopodium|microvillus membrane|nucleolus|ruffle membrane	actin filament binding|cell adhesion molecule binding		EZR/ROS1(4)	breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(2)|lung(1)|ovary(1)|prostate(2)	15		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-17)|BRCA - Breast invasive adenocarcinoma(81;6.58e-06)		TCCAGGTCCTGAGCAATCTTC	0.393000			T	ROS1	NSCLC								9	112					2.17888e-05	4.10715e-05	0.006214	1	0
ADAM29	11086	broad.mit.edu	37	4	175898900	175898900	+	Nonsense_Mutation	SNP	C	C	T	rs114366167	by1000genomes	TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr4:175898900C>T	ENST00000359240.3	+	5	2894	c.2224C>T	c.(2224-2226)Caa>Taa	p.Q742*	ADAM29_ENST00000445694.1_Nonsense_Mutation_p.Q742*|ADAM29_ENST00000404450.4_Nonsense_Mutation_p.Q742*|RP13-577H12.2_ENST00000507525.1_RNA|ADAM29_ENST00000514159.1_Nonsense_Mutation_p.Q742*	NM_001278125.1|NM_014269.4	NP_001265054.1|NP_055084.3	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29	742	9 X 9 AA approximate repeats.				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(25)|ovary(3)|pancreas(1)|prostate(7)|skin(24)|urinary_tract(2)	93		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		TTCCCAGAGTCAACCTCCTGT	0.527000													10	159					0	0	0.006214	0	0
TRIO	7204	broad.mit.edu	37	5	14381297	14381297	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr5:14381297G>T	ENST00000344204.4	+	21	3530	c.3506G>T	c.(3505-3507)gGc>gTc	p.G1169V	TRIO_ENST00000509967.2_Missense_Mutation_p.G1120V|TRIO_ENST00000537187.1_Missense_Mutation_p.G1169V	NM_007118.2	NP_009049.2	O75962	TRIO_HUMAN	trio Rho guanine nucleotide exchange factor	1169					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(21)|lung(34)|ovary(4)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	118	Lung NSC(4;0.000742)					ACCTCCACGGGCTCCAGTATA	0.502000													4	123					1.23904e-05	2.34306e-05	0.000602	1	0
UVSSA	57654	broad.mit.edu	37	4	1347046	1347046	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr4:1347046C>T	ENST00000389851.4	+	5	1226	c.779C>T	c.(778-780)tCt>tTt	p.S260F	UVSSA_ENST00000507531.1_Missense_Mutation_p.S260F|UVSSA_ENST00000511216.1_Missense_Mutation_p.S260F	NM_020894.2	NP_065945.2	Q2YD98	K1530_HUMAN	UV-stimulated scaffold protein A	260																	CTGCCTGCCTCTGCAGGCCAC	0.706000													9	36					0	0	0.004482	0	0
RTP3	83597	broad.mit.edu	37	3	46542062	46542062	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr3:46542062G>C	ENST00000296142.3	+	2	944	c.372G>C	c.(370-372)aaG>aaC	p.K124N		NM_031440.1	NP_113628.1	Q9BQQ7	RTP3_HUMAN	receptor (chemosensory) transporter protein 3	124					detection of chemical stimulus involved in sensory perception of bitter taste|protein targeting to membrane	cytoplasm|integral to membrane	protein binding			endometrium(1)|lung(4)|ovary(3)|prostate(1)|urinary_tract(1)	10				BRCA - Breast invasive adenocarcinoma(193;0.00114)|KIRC - Kidney renal clear cell carcinoma(197;0.0173)|Kidney(197;0.0204)		GAATTCTGAAGAAATGCTATA	0.448000													15	144					0	0	0.002450	0	0
EPS8L2	64787	broad.mit.edu	37	11	723320	723320	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr11:723320C>T	ENST00000533256.1	+	16	1796	c.1421C>T	c.(1420-1422)gCc>gTc	p.A474V	AP006621.9_ENST00000527021.2_RNA|EPS8L2_ENST00000318562.8_Missense_Mutation_p.A474V|EPS8L2_ENST00000526198.1_Missense_Mutation_p.A490V|EPS8L2_ENST00000530636.1_Missense_Mutation_p.A474V			Q9H6S3	ES8L2_HUMAN	EPS8-like 2	474						cytoplasm				NS(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|pancreas(1)|prostate(2)|soft_tissue(1)|urinary_tract(1)	13		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;4.37e-27)|Epithelial(43;2.81e-26)|OV - Ovarian serous cystadenocarcinoma(40;1.33e-20)|BRCA - Breast invasive adenocarcinoma(625;4.29e-05)|Lung(200;0.0582)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CCGGGGGATGCCCTACCACCA	0.572000											OREG0020659	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	82					0	0	0.004007	0	0
ADAMTS10	81794	broad.mit.edu	37	19	8670214	8670214	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr19:8670214C>A	ENST00000270328.4	-	3	384	c.118G>T	c.(118-120)Gag>Tag	p.E40*	ADAMTS10_ENST00000597188.1_Nonsense_Mutation_p.E40*|ADAMTS10_ENST00000596709.1_5'UTR			Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 10	40					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(16)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(3)|skin(10)|urinary_tract(1)	53						AAGGCGATCTCATAGCTCTCC	0.667000													3	11					0.004672	0.008614	0.004672	1	0
KLF10	7071	broad.mit.edu	37	8	103664522	103664522	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr8:103664522G>A	ENST00000395884.3	-	2	1009	c.107C>T	c.(106-108)tCa>tTa	p.S36L	KLF10_ENST00000285407.6_Missense_Mutation_p.S47L	NM_001032282.2	NP_001027453.1	Q13118	KLF10_HUMAN	Kruppel-like factor 10	47					cell proliferation|cell-cell signaling|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|skeletal system development|transforming growth factor beta receptor signaling pathway	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(8)|prostate(3)	18	all_epithelial(15;5.63e-07)|Lung NSC(17;8.18e-05)|all_lung(17;0.000169)		OV - Ovarian serous cystadenocarcinoma(57;0.000112)|STAD - Stomach adenocarcinoma(118;0.0826)			GCAGCTCATTGACATAAGTGC	0.388000													28	191					0	0	0.006320	0	0
ZBTB47	92999	broad.mit.edu	37	3	42700994	42700994	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr3:42700994G>A	ENST00000457842.3	+	2	1428	c.19G>A	c.(19-21)Gag>Aag	p.E7K	ZBTB47_ENST00000232974.6_Missense_Mutation_p.E383K|ZBTB47_ENST00000505904.1_Intron	NM_145166.3	NP_660149.2	Q9UFB7	ZBT47_HUMAN	zinc finger and BTB domain containing 47	7					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|large_intestine(2)|lung(3)|ovary(1)	13				KIRC - Kidney renal clear cell carcinoma(284;0.216)		ACGGTCCCGGGAGAACGCCCG	0.731000													5	13					0	0	0.001168	0	0
MAEL	84944	broad.mit.edu	37	1	166974525	166974525	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr1:166974525G>C	ENST00000367872.4	+	8	980	c.736G>C	c.(736-738)Gag>Cag	p.E246Q	MAEL_ENST00000491055.1_3'UTR|MAEL_ENST00000367870.2_Missense_Mutation_p.E215Q	NM_032858.1	NP_116247.1	Q96JY0	MAEL_HUMAN	maelstrom spermatogenic transposon silencer	246					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|multicellular organismal development|piRNA metabolic process|spermatogenesis	piP-body	DNA binding			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(12)|skin(4)	28						TCTCACTGTAGAGGACCTTGT	0.393000													9	59					0	0	0.004482	0	0
ARID2	196528	broad.mit.edu	37	12	46242729	46242729	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr12:46242729C>T	ENST00000334344.6	+	13	1863	c.1691C>T	c.(1690-1692)tCa>tTa	p.S564L	ARID2_ENST00000444670.1_Missense_Mutation_p.S174L|ARID2_ENST00000479608.1_3'UTR|ARID2_ENST00000422737.1_Missense_Mutation_p.S415L	NM_152641.2	NP_689854.2	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	564					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|liver(20)|lung(34)|ovary(7)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	116	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		ATCCTAACATCAACTGGATTT	0.343000			"""N, S, F"""		hepatocellular carcinoma								12	93					0	0	0.001855	0	0
SCNN1D	6339	broad.mit.edu	37	1	1221321	1221321	+	Frame_Shift_Del	DEL	C	C	-			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr1:1221321delC	ENST00000338555.2	+	4	1226	c.82delC	c.(82-84)cccfs	p.P29fs	SCNN1D_ENST00000400928.3_Frame_Shift_Del_p.P29fs|SCNN1D_ENST00000379116.5_Frame_Shift_Del_p.P193fs|SCNN1D_ENST00000325425.8_Frame_Shift_Del_p.P95fs					sodium channel, non-voltage-gated 1, delta subunit											lung(6)|skin(1)	7	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;2.46e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.199)		AGCCCAGACGCCCCCCAGGCC	0.706													2	4	---	---	---	---					
PTPN18	26469	broad.mit.edu	37	2	131129929	131129934	+	In_Frame_Del	DEL	GACGGG	GACGGG	-	rs112040677		TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr2:131129929_131129934delGACGGG	ENST00000175756.5	+	13	1214_1219	c.1113_1118delGACGGG	c.(1111-1119)cagacgggg>cag	p.TG378del	PTPN18_ENST00000347849.3_In_Frame_Del_p.TG271del	NM_014369.3	NP_055184.2	Q99952	PTN18_HUMAN	protein tyrosine phosphatase, non-receptor type 18 (brain-derived)	378				Missing (in Ref. 1; CAA56105).		cytoplasm|nucleus	non-membrane spanning protein tyrosine phosphatase activity	p.T378_G379delTG(1)		endometrium(1)|kidney(3)|large_intestine(2)|lung(5)|ovary(3)|prostate(1)	15	Colorectal(110;0.1)					gtgggacgcagacggggacggggacg	0.777													4	8	---	---	---	---					
INTS4P2	644619	broad.mit.edu	37	7	65150816	65150817	+	RNA	INS	-	-	C			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr7:65150816_65150817insC	ENST00000430126.2	+	0	757																											TTCATCCCTCACCCCCCCCCCC	0.465													5	9	---	---	---	---					
FOXE1	2304	broad.mit.edu	37	9	100616701	100616706	+	In_Frame_Del	DEL	GCCGCC	GCCGCC	-	rs11279082		TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr9:100616701_100616706delGCCGCC	ENST00000375123.3	+	1	1166_1171	c.505_510delGCCGCC	c.(505-510)gccgccdel	p.AA177del		NM_004473.3	NP_004464.2	O00358	FOXE1_HUMAN	forkhead box E1 (thyroid transcription factor 2)	177	Ala-rich.|Poly-Ala.				cell migration|embryonic organ morphogenesis|hair follicle morphogenesis|hard palate development|lens morphogenesis in camera-type eye|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|peripheral nervous system development|pharynx development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|soft palate development|thymus development|thyroid gland development|thyroid hormone generation	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			central_nervous_system(1)|endometrium(1)|lung(2)|upper_aerodigestive_tract(1)	5		Acute lymphoblastic leukemia(62;0.158)				Ggctgccgcagccgccgccgccgccg	0.767													8	15	---	---	---	---					
SPTAN1	6709	broad.mit.edu	37	9	131395173	131395182	+	Frame_Shift_Del	DEL	GCGCCTTCCG	GCGCCTTCCG	-	rs148984013		TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr9:131395173_131395182delGCGCCTTCCG	ENST00000372739.3	+	56	7357_7366	c.7247_7256delGCGCCTTCCG	c.(7246-7257)agcgccttccggfs	p.SAFR2416fs	SPTAN1_ENST00000372731.4_Frame_Shift_Del_p.SAFR2411fs|SPTAN1_ENST00000358161.5_Frame_Shift_Del_p.SAFR2416fs	NM_001130438.2	NP_001123910.1	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	2411	EF-hand 3.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			NS(2)|breast(8)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(21)|liver(1)|lung(25)|ovary(5)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	87						GAGATTGAGAGCGCCTTCCGGGCCCTCAGC	0.548													9	192	---	---	---	---					
RBM4	5936	broad.mit.edu	37	11	66411376	66411393	+	In_Frame_Del	DEL	GCAGCAGCCGCTGCTGCT	GCAGCAGCCGCTGCTGCT	-			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr11:66411376_66411393delGCAGCAGCCGCTGCTGCT	ENST00000409406.1	+	2	1645_1662	c.868_885delGCAGCAGCCGCTGCTGCT	c.(868-885)gcagcagccgctgctgctdel	p.AAAAAA290del	RBM4_ENST00000530235.1_Intron|RBM4_ENST00000408993.2_In_Frame_Del_p.AAAAAA290del|RBM4_ENST00000310092.7_In_Frame_Del_p.AAAAAA290del|RBM14-RBM4_ENST00000500635.2_Intron|RBM4_ENST00000514361.3_In_Frame_Del_p.AAAAAA265del|RBM4_ENST00000506523.2_Intron|RBM14-RBM4_ENST00000412278.2_In_Frame_Del_p.AAAAAA265del|RBM4_ENST00000515838.2_3'UTR|RBM4_ENST00000396053.4_Intron|RBM4_ENST00000578778.1_Intron|RBM4_ENST00000398692.4_Intron|RBM4_ENST00000503028.2_In_Frame_Del_p.AAAAAA290del					RNA binding motif protein 4											endometrium(3)|large_intestine(4)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13				Lung(977;0.0112)|LUSC - Lung squamous cell carcinoma(976;0.0266)		tgctgctgcagcagcagccgctgctgctgttactgcag	0.619													13	139	---	---	---	---					
DNM1P47	100216544	broad.mit.edu	37	15	102293062	102293064	+	RNA	DEL	CTC	CTC	-	rs4965539		TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr15:102293062_102293064delCTC	ENST00000561463.1	+	0	1108_1110																											AGTTCATCTTCTCAGAGCTGCTG	0.576													2	4	---	---	---	---					
IL9RP3	729486	broad.mit.edu	37	16	81973	81974	+	RNA	INS	-	-	GTCC			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr16:81973_81974insGTCC	ENST00000568710.1	-	0	349																											ATCAGCAGGAGGCCCACCTCGT	0.614													7	62	---	---	---	---					
KANSL1	284058	broad.mit.edu	37	17	44248803	44248807	+	Frame_Shift_Del	DEL	GAATT	GAATT	-			TCGA-FD-A6TB-01A-12D-A339-08	TCGA-FD-A6TB-10A-21D-A339-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ceab2224-d96f-4033-bc35-48a3a5ec874c	0f1ad1e0-e453-4493-894d-82da6a6e6369	g.chr17:44248803_44248807delGAATT	ENST00000262419.6	-	2	1173_1177	c.703_707delAATTC	c.(703-708)aattccfs	p.NS235fs	KANSL1_ENST00000572904.1_Frame_Shift_Del_p.NS235fs|KANSL1_ENST00000432791.1_Frame_Shift_Del_p.NS235fs|KANSL1_ENST00000393476.3_5'UTR|KANSL1_ENST00000574590.1_Frame_Shift_Del_p.NS235fs|KANSL1_ENST00000575318.1_Frame_Shift_Del_p.NS235fs	NM_001193466.1	NP_001180395	Q7Z3B3	K1267_HUMAN	KAT8 regulatory NSL complex subunit 1	235						MLL1 complex	protein binding										CTGTTCCATGGAATTGACAGAGGAT	0.454													23	131	---	---	---	---