Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MUC16	94025	broad.mit.edu	37	19	9016709	9016709	+	Silent	SNP	G	G	T			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr19:9016709G>T	ENST00000397910.4	-	28	38231	c.38028C>A	c.(38026-38028)tcC>tcA	p.S12676S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	12678					cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGTCCACTGTGGAGGTCCCAG	0.488000													6	36					0.000157383	0.000163729	1	1	0
EYS	346007	broad.mit.edu	37	6	66204780	66204780	+	Missense_Mutation	SNP	T	T	G			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr6:66204780T>G	ENST00000503581.1	-	4	1061	c.524A>C	c.(523-525)cAg>cCg	p.Q175P	EYS_ENST00000393380.2_Missense_Mutation_p.Q175P|EYS_ENST00000370621.3_Missense_Mutation_p.Q175P|EYS_ENST00000370616.2_Missense_Mutation_p.Q175P|EYS_ENST00000342421.5_Missense_Mutation_p.Q175P|EYS_ENST00000370618.3_Missense_Mutation_p.Q175P	NM_001142800.1	NP_001136272.1	Q5T1H1	EYS_HUMAN	eyes shut homolog (Drosophila)	175	EGF-like 1.				response to stimulus|visual perception	extracellular region	calcium ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	69						CAGAGATTCCTGGCAGAACTG	0.443000													10	50					0	0	1	0	0
ARSD	414	broad.mit.edu	37	X	2827942	2827942	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chrX:2827942C>A	ENST00000381154.1	-	8	1289	c.1214G>T	c.(1213-1215)gGc>gTc	p.G405V		NM_001669.3	NP_001660.2	P51689	ARSD_HUMAN	arylsulfatase D	405						lysosome	arylsulfatase activity|metal ion binding			large_intestine(3)|lung(3)	6		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				AATCACTCGGCCGGCCGGGAG	0.632000													12	71					0.000151284	0.000159965	1	1	0
EP300	2033	broad.mit.edu	37	22	41565575	41565575	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr22:41565575A>G	ENST00000263253.7	+	26	5460	c.4241A>G	c.(4240-4242)tAt>tGt	p.Y1414C	RP1-85F18.6_ENST00000415054.1_RNA	NM_001429.3	NP_001420.2	Q09472	EP300_HUMAN	E1A binding protein p300	1414					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding	p.Y1414C(1)		NS(2)|breast(11)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(31)|kidney(5)|large_intestine(31)|liver(2)|lung(33)|ovary(2)|pancreas(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(16)	171						ACTGCAGTCTATCATGAAATC	0.333000			"""T,  N, F, Mis, O"""	"""MLL, RUNXBP2"""	"""colorectal, breast, pancreatic, AML, ALL, DLBCL"""				Rubinstein-Taybi syndrome				11	34					0	0	1	0	0
TEAD3	7005	broad.mit.edu	37	6	35444184	35444184	+	Silent	SNP	T	T	C			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr6:35444184T>C	ENST00000338863.7	-	9	848	c.621A>G	c.(619-621)tcA>tcG	p.S207S	TEAD3_ENST00000402886.3_Silent_p.S147S	NM_003214.3	NP_003205	Q99594	TEAD3_HUMAN	TEA domain family member 3	207	Pro-rich.|Transcriptional activation (Potential).				female pregnancy|hippo signaling cascade		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|urinary_tract(1)	10						AGGCAGCAGCTGAGGGGAGCG	0.612000													12	118					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228559301	228559301	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr1:228559301C>T	ENST00000570156.2	+	105	23767	c.23693C>T	c.(23692-23694)cCc>cTc	p.P7898L	OBSCN_ENST00000422127.1_Missense_Mutation_p.P6941L|OBSCN_ENST00000366707.4_Missense_Mutation_p.P4575L	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	6941	Protein kinase 2.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GCCAAAGCCCCCTCATTCGAG	0.721000													5	11					0	0	1	0	0
HHLA2	11148	broad.mit.edu	37	3	108076761	108076761	+	Silent	SNP	A	A	G			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr3:108076761A>G	ENST00000357759.5	+	6	1170	c.756A>G	c.(754-756)ccA>ccG	p.P252P	HHLA2_ENST00000467761.1_Silent_p.P252P|HHLA2_ENST00000467562.1_Silent_p.P188P|HHLA2_ENST00000491820.1_Silent_p.P252P|HHLA2_ENST00000489514.2_Silent_p.P252P	NM_007072.2	NP_009003.1	Q9UM44	HHLA2_HUMAN	HERV-H LTR-associating 2	252	Ig-like V-type 2.					integral to membrane				endometrium(2)|large_intestine(1)|lung(14)|ovary(1)	18						ATTTTTCACCAAACCAAGACT	0.353000													25	102					0	0	1	0	0
CROCCP2	84809	broad.mit.edu	37	1	16946434	16946434	+	RNA	SNP	C	C	T	rs367060		TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr1:16946434C>T	ENST00000412962.1	-	0	1085																											CTCAGCCTTCCGCCGGGCCAG	0.672000													5	54					0	0	1	0	0
PCDHA3	56145	broad.mit.edu	37	5	140182069	140182069	+	Silent	SNP	C	C	T			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr5:140182069C>T	ENST00000522353.2	+	1	1287	c.1287C>T	c.(1285-1287)gaC>gaT	p.D429D	PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000532566.2_Silent_p.D429D|PCDHA2_ENST00000520672.2_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018906.2	NP_061729.1														NS(1)|breast(1)|endometrium(16)|kidney(3)|large_intestine(19)|lung(36)|ovary(7)|prostate(8)|skin(3)|stomach(1)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGCTCGGGACGGGGGCTCGC	0.627000													51	180					0	0	1	0	0
DLG2	1740	broad.mit.edu	37	11	83183781	83183781	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr11:83183781G>C	ENST00000398309.2	-	18	2488	c.2018C>G	c.(2017-2019)aCa>aGa	p.T673R	DLG2_ENST00000524982.1_Missense_Mutation_p.T669R|DLG2_ENST00000537455.1_Missense_Mutation_p.T423R|DLG2_ENST00000330014.6_Missense_Mutation_p.T594R|DLG2_ENST00000376104.2_Missense_Mutation_p.T778R|DLG2_ENST00000404783.3_Missense_Mutation_p.T151R|DLG2_ENST00000418306.2_Missense_Mutation_p.T552R|DLG2_ENST00000543673.1_Missense_Mutation_p.T778R|DLG2_ENST00000426717.2_Missense_Mutation_p.T137R|DLG2_ENST00000531015.1_Missense_Mutation_p.T640R|DLG2_ENST00000376106.3_Missense_Mutation_p.T137R|DLG2_ENST00000280241.8_Missense_Mutation_p.T712R|DLG2_ENST00000532653.1_Missense_Mutation_p.T655R	NM_001364.3	NP_001355.2	Q15700	DLG2_HUMAN	discs, large homolog 2 (Drosophila)	673						cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(11)|lung(35)|ovary(3)|pancreas(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	71		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				TTCCTGCCTTGTAACAGGCTC	0.433000													15	98					0	0	1	0	0
DHX29	54505	broad.mit.edu	37	5	54552337	54552337	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr5:54552337C>G	ENST00000251636.5	-	27	4237	c.4089G>C	c.(4087-4089)ttG>ttC	p.L1363F	RP11-506H20.1_ENST00000506435.1_RNA	NM_019030.2	NP_061903.2	Q7Z478	DHX29_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 29	1363							ATP binding|ATP-dependent helicase activity|translation initiation factor activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(11)|lung(6)|ovary(4)|prostate(1)|skin(3)|urinary_tract(2)	46		Lung NSC(810;4.08e-05)|Breast(144;0.0544)|Prostate(74;0.183)				CTGTTTTTATCAATTCCGTAA	0.328000													8	37					0	0	1	0	0
ZNF804B	219578	broad.mit.edu	37	7	88964633	88964633	+	Silent	SNP	A	A	G			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr7:88964633A>G	ENST00000333190.4	+	4	2946	c.2337A>G	c.(2335-2337)ccA>ccG	p.P779P		NM_181646.2	NP_857597.1	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	779						intracellular	zinc ion binding			NS(1)|breast(2)|endometrium(5)|kidney(5)|large_intestine(20)|lung(78)|ovary(5)|pancreas(5)|prostate(2)|skin(11)|soft_tissue(1)|upper_aerodigestive_tract(9)	144	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			AGTCTGAACCACAGAAAGAGA	0.378000										HNSCC(36;0.09)			3	39					0	0	1	0	0
IGHV1-69	28461	broad.mit.edu	37	14	107170028	107170028	+	RNA	SNP	C	C	A	rs11557995		TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr14:107170028C>A	ENST00000390633.2	-	0	314																											CGTGACTCTGCCCTGGAACTT	0.562000													50	437					6.18754e-15	7.45975e-15	1	1	0
PDHA1	5160	broad.mit.edu	37	X	19369504	19369504	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chrX:19369504G>A	ENST00000379806.5	+	5	656	c.511G>A	c.(511-513)Gaa>Aaa	p.E171K	PDHA1_ENST00000545074.1_Missense_Mutation_p.E140K|PDHA1_ENST00000540249.1_Missense_Mutation_p.E133K|PDHA1_ENST00000379805.3_Missense_Mutation_p.E133K|PDHA1_ENST00000422285.2_Missense_Mutation_p.E133K	NM_001173454.1	NP_001166925.1	P08559	ODPA_HUMAN	pyruvate dehydrogenase (lipoamide) alpha 1	133					glycolysis|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	protein binding|pyruvate dehydrogenase (acetyl-transferring) activity			endometrium(1)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)	18	Hepatocellular(33;0.183)				NADH(DB00157)	TTCCGTCCGAGAAATTCTCGC	0.478000													9	140					0	0	1	0	0
RRP7A	27341	broad.mit.edu	37	22	42910193	42910193	+	Silent	SNP	G	G	A			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr22:42910193G>A	ENST00000323013.6	-	6	691	c.676C>T	c.(676-678)Ctg>Ttg	p.L226L		NM_015703.4	NP_056518.2	Q9Y3A4	RRP7A_HUMAN	ribosomal RNA processing 7 homolog A (S. cerevisiae)	226							nucleotide binding|RNA binding			central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|liver(2)|lung(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	10						TCCCTCTCCAGCACCCGCAAG	0.672000													4	33					0	0	1	0	0
ZFHX3	463	broad.mit.edu	37	16	72991446	72991446	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr16:72991446C>A	ENST00000268489.5	-	2	3271	c.2599G>T	c.(2599-2601)Gcc>Tcc	p.A867S	ZFHX3_ENST00000397992.5_Intron	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	867					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				ATGTTCTGGGCCAGGTAGTAT	0.617000													6	104					0.000157383	0.000163729	1	1	0
CAMSAP1	157922	broad.mit.edu	37	9	138715069	138715069	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr9:138715069C>T	ENST00000389532.4	-	11	1502	c.1438G>A	c.(1438-1440)Gct>Act	p.A480T	CAMSAP1_ENST00000312405.6_Missense_Mutation_p.A202T|CAMSAP1_ENST00000483991.1_5'UTR|CAMSAP1_ENST00000409386.3_Missense_Mutation_p.A491T	NM_015447.3	NP_056262.3	Q5T5Y3	CAMP1_HUMAN	calmodulin regulated spectrin-associated protein 1	480						cytoplasm|microtubule				breast(3)|central_nervous_system(2)|endometrium(6)|kidney(4)|large_intestine(11)|lung(16)|ovary(3)|pancreas(1)|skin(1)	47				OV - Ovarian serous cystadenocarcinoma(145;1.4e-06)|Epithelial(140;1.11e-05)		CAACTCGCAGCGTGATGTAGA	0.562000													18	94					0	0	1	0	0
PRAMEF12	390999	broad.mit.edu	37	1	12835919	12835919	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr1:12835919G>A	ENST00000357726.4	+	2	548	c.521G>A	c.(520-522)gGc>gAc	p.G174D		NM_001080830.1	NP_001074299.1	O95522	PRA12_HUMAN	PRAME family member 12	174										NS(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(9)|ovary(3)|skin(1)|urinary_tract(1)	23	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00818)|Colorectal(212;5.04e-06)|Kidney(185;4.99e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000198)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CAGAGAAAAGGCTTACTGCAC	0.512000													19	145					0	0	1	0	0
CNNM3	26505	broad.mit.edu	37	2	97492619	97492619	+	Silent	SNP	G	G	A			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr2:97492619G>A	ENST00000305510.3	+	3	1447	c.1419G>A	c.(1417-1419)aaG>aaA	p.K473K	CNNM3_ENST00000377060.3_Silent_p.K425K|ANKRD23_ENST00000476975.1_Intron	NM_017623.4	NP_060093.3	Q8NE01	CNNM3_HUMAN	cyclin M3	473					ion transport	integral to membrane|plasma membrane	protein binding			NS(1)|kidney(2)|large_intestine(2)|lung(3)|ovary(2)|skin(1)|urinary_tract(2)	13						CCCCTCTGAAGCGGAAGGAGG	0.547000													25	164					0	0	1	0	0
TFAP2C	7022	broad.mit.edu	37	20	55212940	55212940	+	Silent	SNP	G	G	T	rs111436406		TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr20:55212940G>T	ENST00000201031.2	+	7	1467	c.1224G>T	c.(1222-1224)gcG>gcT	p.A408A	TFAP2C_ENST00000544508.1_Silent_p.A239A	NM_003222.3	NP_003213.1	Q92754	AP2C_HUMAN	transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)	408	H-S-H (helix-span-helix), dimerization.				cell-cell signaling|male gonad development|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity	p.A408A(1)		central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	13			Colorectal(105;0.229)			TCTGTGCCGCGGTGTCTGCCC	0.527000													39	119					1.7489e-18	2.12838e-18	1	1	0
EMR1	2015	broad.mit.edu	37	19	6919687	6919687	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr19:6919687G>T	ENST00000312053.4	+	13	1586	c.1549G>T	c.(1549-1551)Ggg>Tgg	p.G517W	EMR1_ENST00000250572.8_Missense_Mutation_p.G517W|EMR1_ENST00000381407.5_Missense_Mutation_p.G376W|EMR1_ENST00000450315.3_Missense_Mutation_p.G340W|EMR1_ENST00000381404.4_Missense_Mutation_p.G465W	NM_001974.4	NP_001965.3	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 1	517	Ser/Thr-rich.				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(8)	62	all_hematologic(4;0.166)					TCGAGTCGTTGGGGGCATAAT	0.468000													4	116					0.000602214	0.000606919	1	1	0
LBP	3929	broad.mit.edu	37	20	36992685	36992685	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr20:36992685C>T	ENST00000217407.2	+	7	870	c.709C>T	c.(709-711)Cgg>Tgg	p.R237W		NM_004139.3	NP_004130.2	P18428	LBP_HUMAN	lipopolysaccharide binding protein	237					acute-phase response|cellular defense response|cellular response to lipoteichoic acid|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|detection of molecule of bacterial origin|innate immune response|lipid transport|lipopolysaccharide transport|lipopolysaccharide-mediated signaling pathway|macrophage activation involved in immune response|negative regulation of tumor necrosis factor production|opsonization|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of macrophage activation|positive regulation of respiratory burst involved in inflammatory response|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of tumor necrosis factor production|Toll signaling pathway	extracellular space	Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|lipid binding|lipopolysaccharide binding|lipoteichoic acid binding|receptor binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(16)|ovary(2)|prostate(1)|urinary_tract(1)	28		Myeloproliferative disorder(115;0.00878)				GGAAGCCCCTCGGGCAACAGC	0.547000													6	72					0	0	1	0	0
UQCRH	7388	broad.mit.edu	37	1	46775912	46775912	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr1:46775912G>A	ENST00000311672.5	+	3	303	c.167G>A	c.(166-168)cGt>cAt	p.R56H		NM_001089591.1|NM_006004.2	NP_001083060.1|NP_005995.2	P07919	QCR6_HUMAN	ubiquinol-cytochrome c reductase hinge protein	56					aerobic respiration|mitochondrial electron transport, ubiquinol to cytochrome c		ubiquinol-cytochrome-c reductase activity			large_intestine(1)|lung(1)|skin(1)|urinary_tract(1)	4	Acute lymphoblastic leukemia(166;0.155)					TGTGATGAGCGTGTATCCTCT	0.512000													4	151					0	0	1	0	0
DACH2	117154	broad.mit.edu	37	X	85969636	85969636	+	Silent	SNP	G	G	A			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chrX:85969636G>A	ENST00000373131.1	+	5	1141	c.978G>A	c.(976-978)caG>caA	p.Q326Q	DACH2_ENST00000508860.1_Silent_p.Q172Q|DACH2_ENST00000373125.4_Silent_p.Q339Q|DACH2_ENST00000510272.1_Silent_p.Q120Q	NM_001139514.1	NP_001132986.1	Q96NX9	DACH2_HUMAN	dachshund homolog 2 (Drosophila)	339					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|nucleotide binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(14)|lung(28)|ovary(5)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	71						CAATGAATCAGATGAACCATC	0.463000													19	105					0	0	1	0	0
HSPG2	3339	broad.mit.edu	37	1	22186376	22186376	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr1:22186376G>A	ENST00000374695.3	-	41	5213	c.5134C>T	c.(5134-5136)Cgt>Tgt	p.R1712C		NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	1712	Ig-like C2-type 2.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	CCATCCTCACGGGACCAATAG	0.652000													12	23					0	0	1	0	0
DMD	1756	broad.mit.edu	37	X	32305647	32305647	+	Splice_Site	SNP	C	C	T			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chrX:32305647C>T	ENST00000357033.4	-	43	6495	c.6289G>A	c.(6289-6291)Ggg>Agg	p.G2097R	DMD_ENST00000378677.2_Splice_Site_p.G2093R	NM_000109.3|NM_004006.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	2097					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				GTTACCTACCCTTGTCGGTCC	0.408000													17	79					0	0	1	0	0
MME	4311	broad.mit.edu	37	3	154886309	154886309	+	Silent	SNP	C	C	T	rs148809350		TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr3:154886309C>T	ENST00000460393.1	+	19	1929	c.1809C>T	c.(1807-1809)ctC>ctT	p.L603L	MME_ENST00000462745.1_Silent_p.L603L|MME_ENST00000492661.1_Silent_p.L603L|MME_ENST00000493237.1_Silent_p.L603L|MME-AS1_ENST00000484721.1_RNA|MME_ENST00000360490.2_Silent_p.L603L	NM_000902.3|NM_007287.2	NP_000893.2|NP_009218.2	P08473	NEP_HUMAN	membrane metallo-endopeptidase	603					cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(31)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	ATGGAGACCTCGTTGACTGGT	0.378000													7	44					0	0	1	0	0
GTF2IRD1	9569	broad.mit.edu	37	7	73932649	73932649	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr7:73932649A>G	ENST00000476977.1	+	5	2293	c.602A>G	c.(601-603)aAg>aGg	p.K201R	GTF2IRD1_ENST00000489094.1_3'UTR|GTF2IRD1_ENST00000424337.2_Missense_Mutation_p.K201R|GTF2IRD1_ENST00000455841.2_Missense_Mutation_p.K233R|GTF2IRD1_ENST00000265755.3_Missense_Mutation_p.K201R			Q9UHL9	GT2D1_HUMAN	GTF2I repeat domain containing 1	201						nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			NS(1)|breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|lung(19)|ovary(6)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						TTCAAGCTCAAGAGGTGAGTG	0.692000													6	41					0	0	1	0	0
ADCY2	108	broad.mit.edu	37	5	7789895	7789895	+	Silent	SNP	C	C	A			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr5:7789895C>A	ENST00000338316.4	+	20	2699	c.2610C>A	c.(2608-2610)gcC>gcA	p.A870A	ADCY2_ENST00000537121.1_Silent_p.A690A	NM_020546.2	NP_065433.2	Q08462	ADCY2_HUMAN	adenylate cyclase 2 (brain)	870					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(56)|ovary(8)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	119						ACTTCCTGGCCAGGAGCCTGA	0.597000													13	27					0.00010058	0.00010723	1	1	0
ALDH3B2	222	broad.mit.edu	37	11	67433123	67433123	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr11:67433123C>G	ENST00000349015.3	-	7	777	c.339G>C	c.(337-339)aaG>aaC	p.K113N	ALDH3B2_ENST00000530069.1_Missense_Mutation_p.K113N	NM_000695.3	NP_000686	P48448	AL3B2_HUMAN	aldehyde dehydrogenase 3 family, member B2	113					alcohol metabolic process|cellular aldehyde metabolic process|lipid metabolic process		3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(5)|prostate(2)|stomach(1)|urinary_tract(1)	18					NADH(DB00157)	TCATGACAATCTTGCCCACAC	0.647000													189	914					0	0	1	0	0
TRIM7	81786	broad.mit.edu	37	5	180622261	180622261	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr5:180622261G>A	ENST00000393315.1	-	7	1514	c.817C>T	c.(817-819)Cgc>Tgc	p.R273C	TRIM7_ENST00000274773.7_Missense_Mutation_p.R481C|TRIM7_ENST00000393319.3_Missense_Mutation_p.R299C|TRIM7_ENST00000422067.2_Missense_Mutation_p.R273C|TRIM7_ENST00000504241.1_5'UTR|TRIM7_ENST00000361809.3_Missense_Mutation_p.R273C	NM_203296.1	NP_976041.1	Q9C029	TRIM7_HUMAN	tripartite motif containing 7	481						cytoplasm|nucleus	zinc ion binding			NS(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(6)|ovary(2)|skin(1)|stomach(1)	17	all_cancers(89;6.03e-06)|all_epithelial(37;7.1e-07)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0684)	all_cancers(40;0.000172)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_lung(500;0.0221)|all_hematologic(541;0.0433)|Lung NSC(249;0.132)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;2e-06)|Epithelial(171;1.35e-05)|OV - Ovarian serous cystadenocarcinoma(192;0.000128)|Kidney(146;0.0674)|GBM - Glioblastoma multiforme(465;0.0802)		TAGAGGTGGCGCATGTCCTCC	0.662000													3	10					0	0	1	0	0
FBXO34	55030	broad.mit.edu	37	14	55818508	55818508	+	Missense_Mutation	SNP	A	A	C			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr14:55818508A>C	ENST00000313833.4	+	2	1645	c.1400A>C	c.(1399-1401)cAg>cCg	p.Q467P	FBXO34_ENST00000440021.1_Missense_Mutation_p.Q467P	NM_017943.3	NP_060413.2	Q9NWN3	FBX34_HUMAN	F-box protein 34	467										breast(2)|kidney(2)|large_intestine(4)|lung(5)|ovary(3)|pancreas(1)|skin(2)|stomach(3)	22						GACAAAGACCAGCCTTCCATT	0.433000													25	178					0	0	1	0	0
CPZ	8532	broad.mit.edu	37	4	8601310	8601310	+	Splice_Site	SNP	G	G	A			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr4:8601310G>A	ENST00000382480.2	+	2	344		c.e2+1		CPZ_ENST00000360986.4_Intron|CPZ_ENST00000315782.6_Intron|CPZ_ENST00000506287.1_3'UTR	NM_001014448.2	NP_001014448	Q66K79	CBPZ_HUMAN	carboxypeptidase Z						proteolysis|Wnt receptor signaling pathway	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(23)|ovary(3)|pancreas(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						GATTTCAGAAGTGGGTAATGG	0.483000													3	11					0	0	1	0	0
ZBTB21	49854	broad.mit.edu	37	21	43414181	43414181	+	Silent	SNP	G	G	A			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr21:43414181G>A	ENST00000310826.5	-	3	207	c.24C>T	c.(22-24)atC>atT	p.I8I	ZBTB21_ENST00000465968.1_Intron|ZBTB21_ENST00000398499.1_Silent_p.I8I|ZBTB21_ENST00000398511.3_Silent_p.I8I|ZBTB21_ENST00000398505.3_Silent_p.I8I	NM_001098402.1	NP_001091872.1			zinc finger and BTB domain containing 21																		GTGCAGGGTTGATGTAATGCA	0.443000													44	116					0	0	1	0	0
SETD5	55209	broad.mit.edu	37	3	9489680	9489680	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr3:9489680A>G	ENST00000402466.1	+	16	2567	c.1799A>G	c.(1798-1800)aAa>aGa	p.K600R	SETD5_ENST00000407969.1_Missense_Mutation_p.K717R|SETD5_ENST00000302463.6_Missense_Mutation_p.K600R|SETD5_ENST00000406341.1_Missense_Mutation_p.K698R|SETD5_ENST00000402198.1_Missense_Mutation_p.K698R|SETD5_ENST00000488236.1_3'UTR			Q9C0A6	SETD5_HUMAN	SET domain containing 5	698										NS(2)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(11)|ovary(3)|prostate(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.112)		AAATACCCCAAAACCAAAAAG	0.433000													3	30					0	0	1	0	0
ALDH3B2	222	broad.mit.edu	37	11	67433142	67433142	+	Splice_Site	SNP	C	C	T			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr11:67433142C>T	ENST00000349015.3	-	7	758	c.320G>A	c.(319-321)gGg>gAg	p.G107E	ALDH3B2_ENST00000530069.1_Splice_Site_p.G107E	NM_000695.3	NP_000686	P48448	AL3B2_HUMAN	aldehyde dehydrogenase 3 family, member B2	107					alcohol metabolic process|cellular aldehyde metabolic process|lipid metabolic process		3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(5)|prostate(2)|stomach(1)|urinary_tract(1)	18					NADH(DB00157)	ACGAGGGCTCCCTGGGCGTGG	0.642000													150	777					0	0	1	0	0
PCDH11X	27328	broad.mit.edu	37	X	91873850	91873850	+	Nonsense_Mutation	SNP	A	A	T			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chrX:91873850A>T	ENST00000373094.1	+	7	4800	c.3955A>T	c.(3955-3957)Aaa>Taa	p.K1319*	PCDH11X_ENST00000373097.1_Nonsense_Mutation_p.K1309*|PCDH11X_ENST00000373088.1_Nonsense_Mutation_p.K1282*|PCDH11X_ENST00000406881.1_Nonsense_Mutation_p.K1311*|PCDH11X_ENST00000361655.2_Nonsense_Mutation_p.K1301*|PCDH11X_ENST00000504220.2_3'UTR|PCDH11X_ENST00000298274.8_Nonsense_Mutation_p.K1282*	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	1319					homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						TGATTCAATTAAAGTCATTCC	0.453000													35	185					0	0	1	0	0
BMS1P20	96610	broad.mit.edu	37	22	22664186	22664186	+	RNA	SNP	A	A	G			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr22:22664186A>G	ENST00000426066.1	+	0	709					NR_027293.1																						CAGATCAAGAAAGCACTCTGA	0.498000													4	152					0	0	1	0	0
ATP10A	57194	broad.mit.edu	37	15	25925027	25925027	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr15:25925027G>T	ENST00000356865.6	-	21	4072	c.3961C>A	c.(3961-3963)Ccc>Acc	p.P1321T		NM_024490.3	NP_077816.1	O60312	AT10A_HUMAN	ATPase, class V, type 10A	1321					ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|breast(2)|endometrium(8)|kidney(2)|large_intestine(33)|liver(1)|lung(41)|ovary(3)|pancreas(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	103		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		GTCTCTTTGGGAGCACTGCAT	0.572000													22	114					4.35082e-09	5.01121e-09	1	1	0
MDGA1	266727	broad.mit.edu	37	6	37620082	37620082	+	Silent	SNP	G	G	A			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr6:37620082G>A	ENST00000297153.7	-	7	2195	c.1017C>T	c.(1015-1017)gaC>gaT	p.D339D	MDGA1_ENST00000434837.3_Silent_p.D339D|MDGA1_ENST00000505425.1_Silent_p.D339D			Q8NFP4	MDGA1_HUMAN	MAM domain containing glycosylphosphatidylinositol anchor 1	339	Ig-like 4.				brain development|neuron migration|spinal cord association neuron differentiation	anchored to plasma membrane				central_nervous_system(2)|endometrium(6)|kidney(3)|large_intestine(12)|lung(11)|prostate(1)|skin(2)|urinary_tract(1)	38						CTTTGATCACGTCAGGAGTGA	0.572000													6	31					0	0	1	0	0
SNRPN	6638	broad.mit.edu	37	15	25223018	25223018	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr15:25223018C>T	ENST00000444203.2	+	6	1565	c.526C>T	c.(526-528)Cgg>Tgg	p.R176W	SNRPN_ENST00000554227.2_Missense_Mutation_p.R176W|SNURF_ENST00000551312.2_Intron|SNRPN_ENST00000400100.1_Missense_Mutation_p.R172W|SNRPN_ENST00000390687.4_Missense_Mutation_p.R172W|SNRPN_ENST00000577565.1_Missense_Mutation_p.R172W|SNRPN_ENST00000400098.1_Missense_Mutation_p.R172W|SNURF_ENST00000338094.6_3'UTR|SNRPN_ENST00000400097.1_Missense_Mutation_p.R172W|SNRPN_ENST00000346403.6_Missense_Mutation_p.R172W			P63162	RSMN_HUMAN	small nuclear ribonucleoprotein polypeptide N	172	Repeat-rich region.				RNA splicing	small nuclear ribonucleoprotein complex|spliceosomal complex	identical protein binding|RNA binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(14)|ovary(1)|skin(2)	24		all_cancers(20;9.33e-22)|Breast(32;0.000625)		all cancers(64;3.38e-08)|Epithelial(43;3.45e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000207)|GBM - Glioblastoma multiforme(186;0.125)		CCCACCAGGACGGGGCACTCC	0.567000									Prader-Willi syndrome				7	33					0	0	1	0	0
NR0B1	190	broad.mit.edu	37	X	30327119	30327119	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chrX:30327119G>C	ENST00000378970.4	-	1	596	c.362C>G	c.(361-363)cCg>cGg	p.P121R	NR0B1_ENST00000453287.1_Missense_Mutation_p.P121R	NM_000475.4	NP_000466.2	P51843	NR0B1_HUMAN	nuclear receptor subfamily 0, group B, member 1	121	4 X 67 AA tandem repeats.				adrenal gland development|hypothalamus development|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of steroid hormone receptor signaling pathway|pituitary gland development|protein localization|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|steroid biosynthetic process	cytoplasm|membrane fraction|nucleoplasm|nucleus|polysomal ribosome	AF-2 domain binding|DNA hairpin binding|ligand-regulated transcription factor activity|protein domain specific binding|protein homodimerization activity|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|steroid hormone receptor binding|transcription corepressor activity|transcription factor binding			central_nervous_system(2)|endometrium(2)|large_intestine(4)|lung(13)|ovary(1)|skin(2)	24					Dexamethasone(DB01234)|Tretinoin(DB00755)	CCGCCCACCCGGAAGCCCCGC	0.672000											OREG0019719	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	59					0	0	1	0	0
RNF43	54894	broad.mit.edu	37	17	56438251	56438251	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr17:56438251A>G	ENST00000584437.1	-	6	2697	c.742T>C	c.(742-744)Tac>Cac	p.Y248H	BZRAP1-AS1_ENST00000583841.1_RNA|RNF43_ENST00000583753.1_Missense_Mutation_p.Y207H|RNF43_ENST00000407977.2_Missense_Mutation_p.Y248H|RNF43_ENST00000500597.2_Missense_Mutation_p.Y207H|RNF43_ENST00000581868.1_Missense_Mutation_p.Y121H|RNF43_ENST00000577625.1_Missense_Mutation_p.Y121H|RNF43_ENST00000577716.1_Missense_Mutation_p.Y248H			Q68DV7	RNF43_HUMAN	ring finger protein 43	248						endoplasmic reticulum membrane|integral to membrane|nuclear envelope	ligase activity|protein binding|zinc ion binding			NS(1)|biliary_tract(5)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(14)|lung(9)|ovary(2)|pancreas(10)|prostate(1)|skin(4)	60	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CTGGCCTGGTACCTCCTGGTG	0.642000													6	48					0	0	1	0	0
KNDC1	85442	broad.mit.edu	37	10	135025014	135025014	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr10:135025014G>A	ENST00000304613.3	+	22	4018	c.3997G>A	c.(3997-3999)Gtg>Atg	p.V1333M	KNDC1_ENST00000368572.2_Missense_Mutation_p.V1335M			Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND) containing 1	1333	N-terminal Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					NS(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(27)|ovary(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	60		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		CTGCTACGCTGTGGACTTCCC	0.667000													18	97					0	0	1	0	0
CNTN6	27255	broad.mit.edu	37	3	1337296	1337296	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr3:1337296G>T	ENST00000446702.2	+	6	1093	c.466G>T	c.(466-468)Gca>Tca	p.A156S	CNTN6_ENST00000539053.1_Missense_Mutation_p.A84S|CNTN6_ENST00000350110.2_Missense_Mutation_p.A156S			Q9UQ52	CNTN6_HUMAN	contactin 6	156	Ig-like C2-type 2.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				breast(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(34)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		TTTATCTTATGCATGGACCTT	0.363000													9	32					0.000274275	0.000280805	1	1	0
LEPROT	54741	broad.mit.edu	37	1	65895720	65895720	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr1:65895720C>A	ENST00000371065.4	+	3	406	c.268C>A	c.(268-270)Cgt>Agt	p.R90S	LEPROT_ENST00000484243.1_3'UTR|LEPR_ENST00000371060.3_Intron|LEPR_ENST00000371059.3_Intron|LEPR_ENST00000344610.8_Intron|LEPR_ENST00000349533.6_Intron|LEPR_ENST00000406510.3_Intron	NM_001198681.1|NM_017526.4	NP_001185610.1|NP_059996.1	O15243	OBRG_HUMAN	leptin receptor overlapping transcript	90						endosome membrane|Golgi membrane|integral to plasma membrane		p.R90C(1)		kidney(1)|large_intestine(1)|lung(5)	7				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		TATTCTTGCTCGTGTGGCTGT	0.438000													19	226					1.33834e-09	1.55536e-09	1	1	0
ZCCHC24	219654	broad.mit.edu	37	10	81154100	81154100	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr10:81154100C>T	ENST00000372336.3	-	3	730	c.544G>A	c.(544-546)Ggg>Agg	p.G182R	ZCCHC24_ENST00000372333.3_Missense_Mutation_p.R122Q|RP11-342M3.5_ENST00000438554.2_RNA	NM_153367.3	NP_699198.2	Q8N2G6	ZCH24_HUMAN	zinc finger, CCHC domain containing 24	182							nucleic acid binding|zinc ion binding			breast(1)|endometrium(3)|large_intestine(3)|lung(1)|skin(1)	9						CAGGAGTTCCCGCTCATCCAT	0.587000													33	116					0	0	1	0	0
NBPF15	284565	broad.mit.edu	37	1	148594434	148594434	+	Missense_Mutation	SNP	G	G	A	rs143361250	byFrequency	TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr1:148594434G>A	ENST00000442702.2	+	21	2874	c.1807G>A	c.(1807-1809)Gtc>Atc	p.V603I	NBPF15_ENST00000369187.3_Missense_Mutation_p.V603I	NM_001170755.1	NP_001164226.1	Q8N660	NBPFF_HUMAN	neuroblastoma breakpoint family, member 15	603	NBPF 6.					cytoplasm				NS(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|skin(2)	12	all_hematologic(923;0.032)					AGAGCCTGAAGTCTTACAGGA	0.458000													9	264					0	0	1	0	0
FAM71B	153745	broad.mit.edu	37	5	156589643	156589643	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr5:156589643G>A	ENST00000302938.4	-	2	1728	c.1633C>T	c.(1633-1635)Cct>Tct	p.P545S		NM_130899.2	NP_570969.2	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	545						nucleus				NS(3)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(32)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TTTGAACCAGGAGTGGCCCTG	0.463000													39	144					0	0	1	0	0
ALDH3B2	222	broad.mit.edu	37	11	67433048	67433048	+	Silent	SNP	C	C	T			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr11:67433048C>T	ENST00000349015.3	-	7	852	c.414G>A	c.(412-414)gtG>gtA	p.V138V	ALDH3B2_ENST00000530069.1_Silent_p.V138V	NM_000695.3	NP_000686	P48448	AL3B2_HUMAN	aldehyde dehydrogenase 3 family, member B2	138					alcohol metabolic process|cellular aldehyde metabolic process|lipid metabolic process		3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(5)|prostate(2)|stomach(1)|urinary_tract(1)	18					NADH(DB00157)	AGTTGTCGTCCACGTAGCAGG	0.647000													209	937					0	0	1	0	0
GPR82	27197	broad.mit.edu	37	X	41586575	41586575	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chrX:41586575T>C	ENST00000302548.4	+	3	536	c.296T>C	c.(295-297)aTg>aCg	p.M99T	CASK_ENST00000378158.1_Intron|CASK_ENST00000442742.2_Intron|CASK_ENST00000421587.2_Intron|CASK_ENST00000378163.1_Intron|CASK_ENST00000378154.1_Intron|CASK_ENST00000361962.4_Intron|CASK_ENST00000318588.9_Intron|CASK_ENST00000378166.4_Intron	NM_080817.4	NP_543007.1	Q96P67	GPR82_HUMAN	G protein-coupled receptor 82	99						integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(4)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	10						ACTCTATCCATGCATGCAAGT	0.403000													28	68					0	0	1	0	0
PRAMEF11	440560	broad.mit.edu	37	1	12887612	12887612	+	Missense_Mutation	SNP	T	T	C	rs60558629		TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr1:12887612T>C	ENST00000535591.1	-	3	440	c.245A>G	c.(244-246)cAt>cGt	p.H82R		NM_001146344.1	NP_001139816.1	O60813	PRA11_HUMAN	PRAME family member 11	82								p.H82R(1)		NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|lung(7)|pancreas(2)|skin(4)|urinary_tract(1)	27						GAAGCACCCATGGGCCATAGC	0.488000													6	396					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105420634	105420634	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr14:105420634C>G	ENST00000333244.5	-	7	1273	c.1154G>C	c.(1153-1155)cGa>cCa	p.R385P		NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	385						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CATCACTTCTCGATCCTGTTC	0.632000													43	127					0	0	1	0	0
MAGEB10	139422	broad.mit.edu	37	X	27839479	27839479	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chrX:27839479G>T	ENST00000356790.2	+	3	301	c.56G>T	c.(55-57)cGa>cTa	p.R19L		NM_182506.3	NP_872312.2	Q96LZ2	MAGBA_HUMAN	melanoma antigen family B, 10	19										NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	26						CGTCAGGCCCGAGGAGGGCTG	0.522000													12	97					2.27111e-07	2.52563e-07	1	1	0
EMR1	2015	broad.mit.edu	37	19	6919688	6919688	+	Missense_Mutation	SNP	G	G	T	rs142114236		TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr19:6919688G>T	ENST00000312053.4	+	13	1587	c.1550G>T	c.(1549-1551)gGg>gTg	p.G517V	EMR1_ENST00000250572.8_Missense_Mutation_p.G517V|EMR1_ENST00000381407.5_Missense_Mutation_p.G376V|EMR1_ENST00000450315.3_Missense_Mutation_p.G340V|EMR1_ENST00000381404.4_Missense_Mutation_p.G465V	NM_001974.4	NP_001965.3	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 1	517	Ser/Thr-rich.				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(8)	62	all_hematologic(4;0.166)					CGAGTCGTTGGGGGCATAATG	0.468000													4	117					0.000602214	0.000606919	1	1	0
DLL1	28514	broad.mit.edu	37	6	170597470	170597470	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr6:170597470C>T	ENST00000366756.3	-	4	860	c.527G>A	c.(526-528)cGc>cAc	p.R176H		NM_005618.3	NP_005609.3	O00548	DLL1_HUMAN	delta-like 1 (Drosophila)	176					cell communication|cell fate determination|hemopoiesis|Notch receptor processing|Notch signaling pathway|regulation of cell adhesion	extracellular region|integral to plasma membrane	calcium ion binding|Notch binding			NS(2)|breast(1)|endometrium(1)|large_intestine(7)|lung(17)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	33		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;6.71e-23)|BRCA - Breast invasive adenocarcinoma(81;4.81e-06)|GBM - Glioblastoma multiforme(31;0.0584)		ACACACGAAGCGGTAGGAGTA	0.657000													7	77					0	0	1	0	0
IRS4	8471	broad.mit.edu	37	X	107977363	107977363	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chrX:107977363C>G	ENST00000372129.2	-	1	2288	c.2212G>C	c.(2212-2214)Gaa>Caa	p.E738Q		NM_003604.2	NP_003595.1	O14654	IRS4_HUMAN	insulin receptor substrate 4	738	CRK-binding.					plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			NS(1)|breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(1)	78						CTTGAATCTTCAAAAGGGGAT	0.488000													21	101					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577568	7577568	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr17:7577568C>A	ENST00000420246.2	-	7	845	c.713G>T	c.(712-714)tGt>tTt	p.C238F	TP53_ENST00000269305.4_Missense_Mutation_p.C238F|TP53_ENST00000445888.2_Missense_Mutation_p.C238F|TP53_ENST00000359597.4_Missense_Mutation_p.C238F|TP53_ENST00000455263.2_Missense_Mutation_p.C238F|TP53_ENST00000413465.2_Missense_Mutation_p.C238F	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	238	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).		C -> F (in sporadic cancers; somatic mutation).|C -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|C -> H (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|C -> R (in sporadic cancers; somatic mutation).|C -> S (in LFS; germline mutation and in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> Y (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C238Y(65)|p.C238F(46)|p.C238S(9)|p.0?(8)|p.?(5)|p.C145F(5)|p.C145Y(5)|p.M237_N239delMCN(4)|p.C238fs*21(1)|p.M237fs*1(1)|p.M144_N146delMCN(1)|p.C238del(1)|p.Y236_M243delYMCNSSCM(1)|p.V225fs*23(1)|p.H233fs*6(1)|p.C238_M246delCNSSCMGGM(1)|p.H233_C242del10(1)|p.N239_C242del(1)|p.C145S(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGAACTGTTACACATGTAGTT	0.572000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			22	41					3.28513e-13	3.8879e-13	1	1	0
KRT27	342574	broad.mit.edu	37	17	38933875	38933875	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr17:38933875C>G	ENST00000301656.3	-	6	1122	c.1082G>C	c.(1081-1083)aGa>aCa	p.R361T	KRT27_ENST00000540723.1_5'UTR	NM_181537.3	NP_853515.2	Q7Z3Y8	K1C27_HUMAN	keratin 27	361	Coil 2.|Rod.					cytoplasm|intermediate filament	structural molecule activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(3)|skin(1)|stomach(1)	21		Breast(137;0.000812)				GGTCTCGGTTCTGACCTGGTG	0.557000													25	300					0	0	1	0	0
OR5H15	403274	broad.mit.edu	37	3	97887733	97887733	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr3:97887733G>T	ENST00000356526.2	+	1	190	c.190G>T	c.(190-192)Ggg>Tgg	p.G64W		NM_001005515.1	NP_001005515.1	A6NDH6	O5H15_HUMAN	olfactory receptor, family 5, subfamily H, member 15	64					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(20)|ovary(1)|prostate(1)|skin(2)|stomach(1)	35						CTTACTCCTTGGGAATTTAGC	0.403000													4	179					0.00024832	0.000256266	1	1	0
ALDOC	230	broad.mit.edu	37	17	26902260	26902260	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr17:26902260G>A	ENST00000226253.4	-	3	680	c.205C>T	c.(205-207)Cgt>Tgt	p.R69C	ALDOC_ENST00000395319.3_Missense_Mutation_p.R69C|ALDOC_ENST00000395321.2_Missense_Mutation_p.R69C	NM_005165.2	NP_005156.1	P09972	ALDOC_HUMAN	aldolase C, fructose-bisphosphate	69					fructose 1,6-bisphosphate metabolic process|gluconeogenesis|glycolysis	cytosol	cytoskeletal protein binding|fructose-bisphosphate aldolase activity			breast(1)|endometrium(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)	11	Lung NSC(42;0.00431)					TTTTTCACACGGTCATCAGCA	0.542000											OREG0024278	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	40					0	0	1	0	0
SMARCAL1	50485	broad.mit.edu	37	2	217279541	217279541	+	Silent	SNP	G	G	A			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr2:217279541G>A	ENST00000357276.4	+	3	444	c.114G>A	c.(112-114)tcG>tcA	p.S38S	SMARCAL1_ENST00000358207.5_Silent_p.S38S	NM_014140.3	NP_054859.2	Q9NZC9	SMAL1_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1	38					chromatin modification|DNA metabolic process|regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity	p.S38S(1)		NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(10)|liver(1)|lung(15)|ovary(3)|prostate(1)|skin(1)	42		Renal(323;0.0458)		Epithelial(149;9.48e-06)|all cancers(144;0.000621)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0111)		GGACTAGCTCGGGCACCTCCA	0.507000									Schimke Immuno-Osseous Dysplasia				47	208					0	0	1	0	0
PRLR	5618	broad.mit.edu	37	5	35066111	35066111	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr5:35066111C>A	ENST00000382002.5	-	10	1375	c.949G>T	c.(949-951)Gta>Tta	p.V317L	PRLR_ENST00000511486.1_Missense_Mutation_p.V216L|PRLR_ENST00000513753.1_Intron|PRLR_ENST00000348262.3_Intron|PRLR_ENST00000231423.3_Missense_Mutation_p.V317L|PRLR_ENST00000342362.5_Missense_Mutation_p.V216L|PRLR_ENST00000542609.1_Intron|PRLR_ENST00000397391.3_Intron|PRLR_ENST00000310101.5_Missense_Mutation_p.V317L	NM_000949.5	NP_000940.1	P16471	PRLR_HUMAN	prolactin receptor	317					activation of JAK2 kinase activity|activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|embryo implantation|lactation|steroid biosynthetic process|T cell activation	cell surface|extracellular region|integral to membrane	metal ion binding|ornithine decarboxylase activator activity|peptide hormone binding|prolactin receptor activity|protein homodimerization activity			central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(29)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	48	all_lung(31;3.83e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)		Dromostanolone(DB00858)|Fluoxymesterone(DB01185)|Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	CTATCATCTACTTCTAAATAC	0.453000													8	72					5.18039e-06	5.71171e-06	1	1	0
TAF1C	9013	broad.mit.edu	37	16	84213622	84213622	+	Silent	SNP	G	G	A			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr16:84213622G>A	ENST00000567759.1	-	13	1811	c.1629C>T	c.(1627-1629)ctC>ctT	p.L543L	TAF1C_ENST00000566732.1_Silent_p.L517L|TAF1C_ENST00000378541.4_Silent_p.L543L|TAF1C_ENST00000341690.6_Silent_p.L449L|TAF1C_ENST00000570117.1_Silent_p.L211L|TAF1C_ENST00000541676.1_Silent_p.L450L	NM_005679.3	NP_005670	Q15572	TAF1C_HUMAN	TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa	543					regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding			endometrium(1)|kidney(3)|large_intestine(3)|lung(11)|ovary(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	26						GAAATGCAGGGAGGGAGTCGA	0.652000													14	30					0	0	1	0	0
STUB1	10273	broad.mit.edu	37	16	731257	731257	+	Silent	SNP	C	C	T			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr16:731257C>T	ENST00000565677.1	+	2	656	c.49C>T	c.(49-51)Ctg>Ttg	p.L17L	STUB1_ENST00000566181.2_3'UTR|STUB1_ENST00000564370.1_Silent_p.L17L|STUB1_ENST00000219548.4_Silent_p.L89L			Q9UNE7	CHIP_HUMAN	STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase	89					cellular response to misfolded protein|DNA repair|misfolded or incompletely synthesized protein catabolic process|positive regulation of cellular chaperone-mediated protein complex assembly|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process|protein autoubiquitination|protein K63-linked ubiquitination|protein maturation|regulation of glucocorticoid metabolic process|ubiquitin-dependent SMAD protein catabolic process	cytoplasm|nuclear inclusion body|ubiquitin conjugating enzyme complex|ubiquitin ligase complex	Hsp70 protein binding|Hsp90 protein binding|kinase binding|misfolded protein binding|protein binding, bridging|protein homodimerization activity|SMAD binding|TPR domain binding|ubiquitin-ubiquitin ligase activity			endometrium(2)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	6		Hepatocellular(780;0.00335)				CGCCCTGGAGCTGGACGGGCA	0.637000													6	31					0	0	1	0	0
PPP4R4	57718	broad.mit.edu	37	14	94722857	94722857	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr14:94722857G>T	ENST00000304338.3	+	17	2080	c.1926G>T	c.(1924-1926)aaG>aaT	p.K642N		NM_058237.1	NP_478144.1	Q6NUP7	PP4R4_HUMAN	protein phosphatase 4, regulatory subunit 4	642						cytoplasm|protein serine/threonine phosphatase complex	protein binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(15)|lung(10)|skin(7)|upper_aerodigestive_tract(2)	40						CTGCTGATAAGCATCTACTTC	0.343000													7	23					8.12818e-05	8.7378e-05	1	1	0
MYO9B	4650	broad.mit.edu	37	19	17213124	17213124	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr19:17213124C>A	ENST00000595618.1	+	2	749	c.597C>A	c.(595-597)taC>taA	p.Y199*	MYO9B_ENST00000593411.1_3'UTR|MYO9B_ENST00000594824.1_Nonsense_Mutation_p.Y199*|MYO9B_ENST00000397274.2_Nonsense_Mutation_p.Y199*	NM_001130065.1|NM_004145.3	NP_001123537.1|NP_004136.2	Q13459	MYO9B_HUMAN	myosin IXB	199	Myosin head-like.				actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(3)|endometrium(9)|kidney(2)|large_intestine(1)|lung(19)|soft_tissue(1)|urinary_tract(4)	39						ACCCCAAGTACGTGAAGATGT	0.567000													43	198					9.39024e-22	1.16475e-21	1	1	0
OTOGL	283310	broad.mit.edu	37	12	80647296	80647296	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr12:80647296G>A	ENST00000458043.2	+	13	1315	c.1309G>A	c.(1309-1311)Ggt>Agt	p.G437S	OTOGL_ENST00000547103.1_Missense_Mutation_p.G437S	NM_173591.3	NP_775862.3			otogelin-like											breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						TTGCCCATGCGGTTTTCATGG	0.363000													9	59					0	0	1	0	0
SLC17A8	246213	broad.mit.edu	37	12	100751232	100751232	+	Silent	SNP	G	G	A			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr12:100751232G>A	ENST00000323346.5	+	1	376	c.63G>A	c.(61-63)gtG>gtA	p.V21V	SLC17A8_ENST00000392989.3_Silent_p.V21V	NM_001145288.1|NM_139319.2	NP_001138760.1|NP_647480.1	Q8NDX2	VGLU3_HUMAN	solute carrier family 17 (vesicular glutamate transporter), member 8	21					neurotransmitter transport|sensory perception of sound|sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(25)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	44						AGGAAGGAGTGAAGAACGCCG	0.408000													9	121					0	0	1	0	0
ECT2L	345930	broad.mit.edu	37	6	139206935	139206935	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr6:139206935C>A	ENST00000423192.1	+	17	2388	c.2227C>A	c.(2227-2229)Caa>Aaa	p.Q743K	ECT2L_ENST00000541398.1_Intron|ECT2L_ENST00000367682.2_Missense_Mutation_p.Q743K			Q008S8	ECT2L_HUMAN	epithelial cell transforming sequence 2 oncogene-like	743	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(7)|lung(12)|skin(1)|upper_aerodigestive_tract(1)	30						TGCAATTGACCAAATCAAAAA	0.408000			"""N, Splice, Mis"""		ETP ALL								10	51					3.86212e-05	4.22215e-05	1	1	0
DNM1P47	100216544	broad.mit.edu	37	15	102303426	102303426	+	RNA	SNP	A	A	C			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr15:102303426A>C	ENST00000561463.1	+	0	11472																											TGGGAACAAGAAGACACTCGT	0.572000													3	8					0	0	1	0	0
COL6A6	131873	broad.mit.edu	37	3	130380587	130380587	+	Silent	SNP	T	T	A			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr3:130380587T>A	ENST00000358511.6	+	34	5968	c.5937T>A	c.(5935-5937)gcT>gcA	p.A1979A	COL6A6_ENST00000453409.2_Silent_p.A1979A	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	1979	Nonhelical region.|VWFA 9.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						TGGGAAGTGCTGAATTTGAAG	0.522000													19	37					0	0	1	0	0
AMT	275	broad.mit.edu	37	3	49459813	49459813	+	Missense_Mutation	SNP	C	C	T	rs142950858		TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr3:49459813C>T	ENST00000273588.3	-	1	373	c.71G>A	c.(70-72)cGt>cAt	p.R24H	AMT_ENST00000538581.1_Missense_Mutation_p.R24H|AMT_ENST00000395338.2_Missense_Mutation_p.R24H|AMT_ENST00000476226.1_5'UTR|AMT_ENST00000546031.1_5'UTR|AMT_ENST00000458307.2_Missense_Mutation_p.R24H	NM_000481.3	NP_000472.2	P48728	GCST_HUMAN	aminomethyltransferase	24					glycine catabolic process	mitochondrion	aminomethyltransferase activity|transaminase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)|skin(1)	6				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	NADH(DB00157)|Tetrahydrofolic acid(DB00116)	ACTAAGTGGACGACACAAGGC	0.657000													6	64					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179471787	179471787	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr2:179471787G>A	ENST00000589042.1	-	278	53766	c.53542C>T	c.(53542-53544)Cct>Tct	p.P17848S	TTN_ENST00000342175.6_Missense_Mutation_p.P8975S|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.P8783S|TTN-AS1_ENST00000589234.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.P8908S|TTN_ENST00000591111.1_Missense_Mutation_p.P16207S|TTN_ENST00000342992.6_Missense_Mutation_p.P15280S|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000589830.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	16207	Fibronectin type-III 29.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATTTCAACAGGAGGGCCACAG	0.373000													23	80					0	0	1	0	0
C3	718	broad.mit.edu	37	19	6713200	6713200	+	Splice_Site	SNP	C	C	T			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr19:6713200C>T	ENST00000245907.6	-	9	1095	c.1003G>A	c.(1003-1005)Ggc>Agc	p.G335S		NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	335					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		TGGGCCTCACCTGAGTGCAAG	0.607000													10	65					0	0	1	0	0
VPS41	27072	broad.mit.edu	37	7	38813788	38813788	+	Silent	SNP	A	A	C			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr7:38813788A>C	ENST00000310301.4	-	12	993	c.939T>G	c.(937-939)acT>acG	p.T313T	VPS41_ENST00000466017.1_5'UTR|VPS41_ENST00000395969.2_Silent_p.T288T	NM_014396.3	NP_055211.2	P49754	VPS41_HUMAN	vacuolar protein sorting 41 homolog (S. cerevisiae)	313					Golgi vesicle transport|intracellular protein transport|vesicle-mediated transport	cytosol|Golgi-associated vesicle|HOPS complex|membrane fraction	zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(5)|lung(17)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	44						TCTCTTCACAAGTCTCAGAAA	0.398000													5	223					0	0	1	0	0
IGHV1-24	28467	broad.mit.edu	37	14	106733553	106733553	+	RNA	SNP	G	G	C			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr14:106733553G>C	ENST00000390610.2	-	0	86																											CTGCCACCAAGAAGAGGATCC	0.577000													4	130					0	0	1	0	0
ZFHX3	463	broad.mit.edu	37	16	72845821	72845821	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr16:72845821C>T	ENST00000268489.5	-	6	4318	c.3646G>A	c.(3646-3648)Gag>Aag	p.E1216K	ZFHX3_ENST00000397992.5_Missense_Mutation_p.E302K	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	1216					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				GGTTTGATCTCCTCAGCTGTT	0.542000													53	370					0	0	1	0	0
OR5D18	219438	broad.mit.edu	37	11	55587527	55587527	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr11:55587527T>C	ENST00000333976.4	+	1	442	c.422T>C	c.(421-423)cTc>cCc	p.L141P		NM_001001952.1	NP_001001952.1	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D, member 18	141					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(3)|large_intestine(6)|lung(33)|ovary(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		all_epithelial(135;0.208)				TCCCAGAAACTCTGCGTGCTG	0.468000													31	199					0	0	1	0	0
PDE3B	5140	broad.mit.edu	37	11	14808038	14808038	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr11:14808038T>C	ENST00000282096.4	+	3	1438	c.1085T>C	c.(1084-1086)aTg>aCg	p.M362T	PDE3B_ENST00000455098.2_Missense_Mutation_p.M362T	NM_000922.3	NP_000913.2	Q13370	PDE3B_HUMAN	phosphodiesterase 3B, cGMP-inhibited	362					cAMP catabolic process|insulin receptor signaling pathway|negative regulation of lipid catabolic process|platelet activation	cytosol|endoplasmic reticulum|Golgi apparatus|guanyl-nucleotide exchange factor complex|integral to membrane|microsome	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding|protein kinase B binding			NS(1)|breast(1)|endometrium(5)|kidney(3)|large_intestine(6)|lung(15)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						GCTCGCAATATGGTGTCAGAT	0.408000													36	94					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414340	20414340	+	Silent	SNP	G	G	A			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr9:20414340G>A	ENST00000380338.4	-	5	790	c.504C>T	c.(502-504)agC>agT	p.S168S	MLLT3_ENST00000429426.2_Silent_p.S165S|MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000355930.6_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	168	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S168S(5)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctgctactgctgc	0.537000			T	MLL	ALL								6	77					0	0	1	0	0
ADAMTS3	9508	broad.mit.edu	37	4	73169717	73169717	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr4:73169717C>A	ENST00000286657.4	-	17	2377	c.2341G>T	c.(2341-2343)Ggt>Tgt	p.G781C		NM_014243.2	NP_055058.2	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 3	781	Spacer.				collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(33)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	76			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			CACTCCACACCAAGATCTATG	0.413000													34	194					9.8876e-21	1.21476e-20	1	1	0
CROCCP2	84809	broad.mit.edu	37	1	16946438	16946438	+	RNA	SNP	G	G	A	rs28392876	by1000genomes	TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr1:16946438G>A	ENST00000412962.1	-	0	1081																											GCCTTCCGCCGGGCCAGCAGC	0.672000													5	51					0	0	1	0	0
CDH13	1012	broad.mit.edu	37	16	83712002	83712002	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr16:83712002G>A	ENST00000566620.1	+	10	1764	c.1474G>A	c.(1474-1476)Gtg>Atg	p.V492M	CDH13_ENST00000428848.3_Missense_Mutation_p.V453M|CDH13_ENST00000268613.10_Missense_Mutation_p.V539M	NM_001220488.1|NM_001220489.1|NM_001220490.1|NM_001257.4	NP_001207417.1|NP_001207418.1|NP_001207419.1|NP_001248.1	P55290	CAD13_HUMAN	cadherin 13	492	Cadherin 4.				adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding	p.V492L(1)		large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)		GGACCTCTCTGTGGGCAGCGT	0.617000													17	93					0	0	1	0	0
RABGGTB	5876	broad.mit.edu	37	1	76257197	76257197	+	Missense_Mutation	SNP	T	T	A			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr1:76257197T>A	ENST00000319942.3	+	6	591	c.520T>A	c.(520-522)Tgt>Agt	p.C174S	RABGGTB_ENST00000496055.1_3'UTR|RABGGTB_ENST00000535300.1_5'UTR	NM_004582.3	NP_004573.2	P53611	PGTB2_HUMAN	Rab geranylgeranyltransferase, beta subunit	174					protein modification process|visual perception		metal ion binding|protein binding|Rab geranylgeranyltransferase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(7)|ovary(1)	19						TGTTTTATCCTGTATGAACTT	0.373000													22	108					0	0	1	0	0
ZNF728	388523	broad.mit.edu	37	19	23159340	23159340	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr19:23159340G>A	ENST00000594710.1	-	4	944	c.799C>T	c.(799-801)Cgg>Tgg	p.R267W		NM_001267716.1	NP_001254645.1			zinc finger protein 728																		CTTGAGGACCGGGTGAAGGCT	0.413000													33	60					0	0	1	0	0
KCNIP4	80333	broad.mit.edu	37	4	21698994	21698994	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr4:21698994A>T	ENST00000382148.3	-	1	403	c.67T>A	c.(67-69)Tta>Ata	p.L23I	KCNIP4_ENST00000382152.2_Intron|KCNIP4_ENST00000447367.2_Intron	NM_001035003.1	NP_001030175.1	Q6PIL6	KCIP4_HUMAN	Kv channel interacting protein 4	0	KIS (By similarity).					plasma membrane	calcium ion binding|potassium channel activity|protein binding|voltage-gated ion channel activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	13		Breast(46;0.134)				GAACCTGTTAATAGTCTGAGA	0.363000													8	58					0	0	1	0	0
ESX1	80712	broad.mit.edu	37	X	103498920	103498920	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chrX:103498920G>A	ENST00000372588.4	-	2	504	c.421C>T	c.(421-423)Cgc>Tgc	p.R141C		NM_153448.3	NP_703149.1	Q8N693	ESX1_HUMAN	ESX homeobox 1	141					negative regulation of transcription, DNA-dependent|regulation of cell cycle	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(10)|lung(12)|ovary(1)|skin(2)	27						GTGCGGCGGCGGCGTTTCCTC	0.642000													22	100					0	0	1	0	0
SHROOM3	57619	broad.mit.edu	37	4	77652089	77652089	+	Splice_Site	SNP	G	G	A			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr4:77652089G>A	ENST00000296043.6	+	4	1540		c.e4+1		SHROOM3_ENST00000473602.1_Splice_Site	NM_020859.3	NP_065910.3	Q8TF72	SHRM3_HUMAN	shroom family member 3						apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(29)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	60			Lung(101;0.0903)			ACCATTCCAGGTAAGTGGCTA	0.433000													40	199					0	0	1	0	0
HERC1	8925	broad.mit.edu	37	15	63948129	63948129	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr15:63948129A>G	ENST00000443617.2	-	50	9983	c.9896T>C	c.(9895-9897)gTa>gCa	p.V3299A		NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	3299					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						GGTTAGATTTACACCTGTTGC	0.368000													3	13					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113353837	113353837	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr8:113353837G>T	ENST00000297405.5	-	42	6765	c.6521C>A	c.(6520-6522)aCt>aAt	p.T2174N	CSMD3_ENST00000343508.3_Missense_Mutation_p.T2134N|CSMD3_ENST00000455883.2_Missense_Mutation_p.T2070N|CSMD3_ENST00000352409.3_Missense_Mutation_p.T2104N	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	2174	CUB 12.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						AACAGTACTAGTTTCTGAGGA	0.378000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			6	90					8.12818e-05	8.7378e-05	1	1	0
NF1	4763	broad.mit.edu	37	17	29553568	29553568	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr17:29553568C>T	ENST00000358273.4	+	18	2500	c.2117C>T	c.(2116-2118)gCc>gTc	p.A706V	NF1_ENST00000356175.3_Missense_Mutation_p.A706V	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1	706					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(4)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		GTTCTGGTTGCCATGTCCTGT	0.527000			"""D, Mis, N, F, S, O"""		"""neurofibroma, glioma"""	"""neurofibroma, glioma"""			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			4	101					0	0	1	0	0
PCYT1B	9468	broad.mit.edu	37	X	24605407	24605407	+	Silent	SNP	C	C	G	rs34701484	byFrequency	TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chrX:24605407C>G	ENST00000379145.1	-	5	506	c.462G>C	c.(460-462)ccG>ccC	p.P154P	PCYT1B_ENST00000356768.4_Silent_p.P172P|PCYT1B_ENST00000379144.2_Silent_p.P172P	NM_001163264.1	NP_001156736.1	Q9Y5K3	PCY1B_HUMAN	phosphate cytidylyltransferase 1, choline, beta	172	Catalytic (Potential).					endoplasmic reticulum	choline-phosphate cytidylyltransferase activity			breast(2)|kidney(1)|large_intestine(5)|lung(8)|ovary(1)	17					Choline(DB00122)	CAGAGGAATACGGAATGTCAT	0.473000													8	59					0	0	1	0	0
HDX	139324	broad.mit.edu	37	X	83724555	83724555	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chrX:83724555A>T	ENST00000297977.5	-	3	287	c.176T>A	c.(175-177)aTg>aAg	p.M59K	HDX_ENST00000373177.2_Missense_Mutation_p.M59K|HDX_ENST00000506585.2_Start_Codon_SNP_p.M1K	NM_001177479.1|NM_144657.4	NP_001170950.1|NP_653258.2	Q7Z353	HDX_HUMAN	highly divergent homeobox	59						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(12)|liver(1)|lung(19)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	48						CTTACTACTCATCTTTCTTCT	0.368000													8	28					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152711530	152711530	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr6:152711530C>A	ENST00000367255.5	-	53	8663	c.8062G>T	c.(8062-8064)Ggg>Tgg	p.G2688W	SYNE1_ENST00000341594.5_Missense_Mutation_p.G2727W|SYNE1_ENST00000448038.1_Missense_Mutation_p.G2695W|SYNE1_ENST00000423061.1_Missense_Mutation_p.G2695W|SYNE1_ENST00000265368.4_Missense_Mutation_p.G2688W	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2688					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GCCTGTTCCCCCTTGCCAATG	0.453000										HNSCC(10;0.0054)			10	40					4.68919e-08	5.30619e-08	1	1	0
IGSF3	3321	broad.mit.edu	37	1	117142736	117142736	+	Missense_Mutation	SNP	A	A	G	rs138851517		TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr1:117142736A>G	ENST00000369486.3	-	7	2621	c.1856T>C	c.(1855-1857)aTc>aCc	p.I619T	IGSF3_ENST00000369483.1_Missense_Mutation_p.I639T|IGSF3_ENST00000318837.6_Missense_Mutation_p.I639T	NM_001007237.1	NP_001007238.1	O75054	IGSF3_HUMAN	immunoglobulin superfamily, member 3	619	Ig-like C2-type 5.					integral to membrane				NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(31)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	62	Lung SC(450;0.225)	all_cancers(81;1.24e-06)|all_epithelial(167;4.85e-07)|all_lung(203;1.66e-06)|Lung NSC(69;1.11e-05)		Lung(183;0.0142)|Colorectal(144;0.0929)|LUSC - Lung squamous cell carcinoma(189;0.108)|COAD - Colon adenocarcinoma(174;0.139)|all cancers(265;0.159)|Epithelial(280;0.166)		AGCCTTCTCGATGGCAGTTCG	0.627000													3	47					0	0	1	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102502903	102502903	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr14:102502903G>A	ENST00000360184.4	+	57	10996	c.10832G>A	c.(10831-10833)cGg>cAg	p.R3611Q	RP11-1017G21.4_ENST00000557551.1_RNA|DYNC1H1_ENST00000556791.1_3'UTR	NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	3611	AAA 5 (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						AAGATCACACGGACCAGCTTC	0.483000													17	137					0	0	1	0	0
ACIN1	22985	broad.mit.edu	37	14	23549405	23549405	+	Missense_Mutation	SNP	A	A	G	rs61740446	byFrequency	TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr14:23549405A>G	ENST00000262710.1	-	6	1640	c.1313T>C	c.(1312-1314)aTa>aCa	p.I438T	ACIN1_ENST00000457657.1_Missense_Mutation_p.I398T|ACIN1_ENST00000555053.1_Missense_Mutation_p.I438T|ACIN1_ENST00000605057.1_Missense_Mutation_p.I380T	NM_001164814.1|NM_014977.3	NP_001158286.1|NP_055792	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	438	Glu-rich.				apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			breast(1)|endometrium(6)|kidney(4)|large_intestine(9)|lung(10)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	37	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		CATGGGCTCTATTTCTTCTTC	0.512000													16	97					0	0	1	0	0
TBP	6908	broad.mit.edu	37	6	170871064	170871064	+	Silent	SNP	G	G	A	rs112748399		TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr6:170871064G>A	ENST00000392092.2	+	3	519	c.240G>A	c.(238-240)caG>caA	p.Q80Q	TBP_ENST00000540980.1_Silent_p.Q60Q|TBP_ENST00000230354.6_Silent_p.Q80Q	NM_003194.4	NP_003185.1	P20226	TBP_HUMAN	TATA box binding protein	80	Poly-Gln.				cell death|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|viral reproduction	transcription factor TFIIA complex|transcription factor TFIID complex	repressing transcription factor binding|transcription regulatory region DNA binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(1)	26		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;1.07e-22)|BRCA - Breast invasive adenocarcinoma(81;5.01e-06)|GBM - Glioblastoma multiforme(31;0.00591)		agcagcagcagcagcagcagc	0.577000													7	55					0	0	1	0	0
DMD	1756	broad.mit.edu	37	X	32591918	32591918	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chrX:32591918G>T	ENST00000357033.4	-	14	1854	c.1648C>A	c.(1648-1650)Cgc>Agc	p.R550S	DMD_ENST00000288447.4_Missense_Mutation_p.R542S|DMD_ENST00000378677.2_Missense_Mutation_p.R546S	NM_000109.3|NM_004006.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	550					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				AGAACCCAGCGGTCTTCTGTC	0.443000													14	34					1.15088e-07	1.29098e-07	1	1	0
ASB17	127247	broad.mit.edu	37	1	76387893	76387893	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr1:76387893T>C	ENST00000284142.6	-	2	692	c.553A>G	c.(553-555)Ata>Gta	p.I185V		NM_080868.2	NP_543144.1	Q8WXJ9	ASB17_HUMAN	ankyrin repeat and SOCS box containing 17	185					intracellular signal transduction					breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(11)|ovary(2)|urinary_tract(1)	21						TAGAGTACTATTGTTAAGACA	0.363000													9	24					0	0	1	0	0
PRAMEF11	440560	broad.mit.edu	37	1	12887606	12887606	+	Missense_Mutation	SNP	C	C	G	rs58074988		TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr1:12887606C>G	ENST00000535591.1	-	3	446	c.251G>C	c.(250-252)tGc>tCc	p.C84S		NM_001146344.1	NP_001139816.1	O60813	PRA11_HUMAN	PRAME family member 11	84								p.C84S(1)		NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|lung(7)|pancreas(2)|skin(4)|urinary_tract(1)	27						ATTGAGGAAGCACCCATGGGC	0.483000													5	395					0	0	1	0	0
NCOA2	10499	broad.mit.edu	37	8	71128946	71128946	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr8:71128946G>T	ENST00000452400.2	-	3	216	c.35C>A	c.(34-36)tCc>tAc	p.S12Y		NM_006540.2	NP_006531.1	Q15596	NCOA2_HUMAN	nuclear receptor coactivator 2	12					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	histone acetyltransferase activity|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|signal transducer activity		PAX3/NCOA2(4)|HEY1/NCOA2(10)	NS(1)|breast(4)|endometrium(7)|kidney(4)|large_intestine(10)|lung(25)|ovary(1)|pancreas(2)|prostate(2)|skin(4)	60	Breast(64;0.201)		Epithelial(68;0.0147)|OV - Ovarian serous cystadenocarcinoma(28;0.0455)|all cancers(69;0.0606)			CTCTGCCCTGGAGGGGTCAGA	0.433000			T	"""RUNXBP2, HEY1"""	"""AML, Chondrosarcoma"""								21	155					3.5997e-14	4.29964e-14	1	1	0
DKC1	1736	broad.mit.edu	37	X	153993191	153993191	+	Nonsense_Mutation	SNP	A	A	T			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chrX:153993191A>T	ENST00000369550.5	+	2	244	c.34A>T	c.(34-36)Aaa>Taa	p.K12*		NM_001142463.1|NM_001363.3	NP_001135935.1|NP_001354.1	O60832	DKC1_HUMAN	dyskeratosis congenita 1, dyskerin	12	Nucleolar localization.|Poly-Lys.				cell proliferation|pseudouridine synthesis|rRNA processing|telomere maintenance via telomerase	Cajal body|nucleolus|telomerase holoenzyme complex	protein binding|pseudouridine synthase activity|RNA binding|telomerase activity			breast(2)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(3)|prostate(1)	15	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					TTTGCCAAAGAAACATAAGAA	0.333000									Congenital Dyskeratosis				20	108					0	0	1	0	0
NXF3	56000	broad.mit.edu	37	X	102338591	102338591	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chrX:102338591C>A	ENST00000395065.3	-	4	482	c.381G>T	c.(379-381)aaG>aaT	p.K127N	NXF3_ENST00000425463.2_Missense_Mutation_p.K38N|NXF3_ENST00000425644.1_5'UTR	NM_022052.1	NP_071335.1	Q9H4D5	NXF3_HUMAN	nuclear RNA export factor 3	127	RRM.					cytoplasm|nuclear RNA export factor complex	nucleocytoplasmic transporter activity|nucleotide binding|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(2)|lung(15)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26						TCAGCAGCCACTTCTCATTGT	0.433000													10	79					4.68919e-08	5.30619e-08	1	1	0
KRT27	342574	broad.mit.edu	37	17	38933922	38933922	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr17:38933922C>G	ENST00000301656.3	-	6	1075	c.1035G>C	c.(1033-1035)caG>caC	p.Q345H	KRT27_ENST00000540723.1_5'UTR	NM_181537.3	NP_853515.2	Q7Z3Y8	K1C27_HUMAN	keratin 27	345	Coil 2.|Rod.					cytoplasm|intermediate filament	structural molecule activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(3)|skin(1)|stomach(1)	21		Breast(137;0.000812)				GAGCCTGGATCTGTGCCAGCT	0.537000													20	279					0	0	1	0	0
NFKBIE	4794	broad.mit.edu	37	6	44227996	44227996	+	Silent	SNP	C	C	T	rs139653621		TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr6:44227996C>T	ENST00000275015.5	-	5	1220	c.1221G>A	c.(1219-1221)gcG>gcA	p.A407A		NM_004556.2	NP_004547.2	O00221	IKBE_HUMAN	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	407					cytoplasmic sequestering of transcription factor		protein binding			breast(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(3)|urinary_tract(1)	10	all_cancers(18;2e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			CCAGGTGCAGCGCTGTCTTAC	0.617000													13	92					0	0	1	0	0
RGS21	431704	broad.mit.edu	37	1	192335194	192335195	+	Frame_Shift_Ins	INS	-	-	A			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr1:192335194_192335195insA	ENST00000417209.2	+	5	573_574	c.399_400insA	c.(400-402)aaafs	p.K134fs		NM_001039152.3	NP_001034241.1	Q2M5E4	RGS21_HUMAN	regulator of G-protein signaling 21	134	RGS.				negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			NS(1)|endometrium(3)|large_intestine(4)|lung(5)|ovary(1)|skin(1)	15						CAGAGATTTATAAAAAACTGGT	0.366													15	63	---	---	---	---					
TMEM131	23505	broad.mit.edu	37	2	98427639	98427639	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr2:98427639delT	ENST00000186436.5	-	18	2148	c.1920delA	c.(1918-1920)aaafs	p.K640fs		NM_015348.1	NP_056163.1	Q92545	TM131_HUMAN	transmembrane protein 131	640						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(4)|prostate(1)|skin(1)|stomach(1)	57						TCCCCTCTAATTTTTTTGCAG	0.393													7	354	---	---	---	---					
CPHL1P	389160	broad.mit.edu	37	3	148999032	148999033	+	RNA	INS	-	-	GAA	rs67798399	by1000genomes	TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr3:148999032_148999033insGAA	ENST00000482639.2	-	0	195																											GGGAAGACACTGAACAGtaaga	0.500													2	4	---	---	---	---					
HLA-F	3134	broad.mit.edu	37	6	29694802	29694803	+	Frame_Shift_Ins	INS	-	-	T	rs17875385		TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr6:29694802_29694803insT	ENST00000259951.7	+	7	1235_1236	c.1179_1180insT	c.(1180-1182)tttfs	p.F394fs	HLA-F_ENST00000440587.2_Intron|HLA-F_ENST00000475996.1_Intron	NM_001098479.1	NP_001091949.1	P30511	HLAF_HUMAN	major histocompatibility complex, class I, F	0					antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex	MHC class I receptor activity			cervix(1)|endometrium(1)|large_intestine(1)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	8						TGTGGATCTTGTTTTTTTTGTG	0.535													7	317	---	---	---	---					
MED27	9442	broad.mit.edu	37	9	134769316	134769318	+	In_Frame_Del	DEL	TTG	TTG	-			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr9:134769316_134769318delTTG	ENST00000292035.5	-	5	698_700	c.635_637delCAA	c.(634-639)acaata>ata	p.T212del	MED27_ENST00000357028.2_Intron	NM_004269.3	NP_004260.2	Q6P2C8	MED27_HUMAN	mediator complex subunit 27	212					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleolus|transcription factor complex	protein binding|transcription coactivator activity			breast(1)|endometrium(4)|kidney(3)|large_intestine(3)|lung(5)|skin(1)|urinary_tract(1)	18		Myeloproliferative disorder(178;0.206)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000193)		CCCTTTACTATTGTTCGATCAAT	0.438													12	55	---	---	---	---					
EGR2	1959	broad.mit.edu	37	10	64573471	64573479	+	In_Frame_Del	DEL	GGCGGCGGC	GGCGGCGGC	-			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr10:64573471_64573479delGGCGGCGGC	ENST00000242480.3	-	2	1244_1252	c.919_927delGCCGCCGCC	c.(919-927)gccgccgccdel	p.AAA307del	EGR2_ENST00000411732.1_In_Frame_Del_p.AAA257del|EGR2_ENST00000439032.1_In_Frame_Del_p.AAA307del	NM_000399.3|NM_001136177.1	NP_000390.2|NP_001129649.1	P11161	EGR2_HUMAN	early growth response 2	307	Poly-Ala.				fat cell differentiation|protein export from nucleus|transcription from RNA polymerase II promoter	cytoplasm|nucleus	chromatin binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|ubiquitin protein ligase binding|zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(10)|lung(13)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)	36	Prostate(12;0.0297)|all_hematologic(501;0.228)					GTGGGTTATAGGCGGCGGCGGCGGCGGCT	0.713													9	58	---	---	---	---					
TUBA1B	10376	broad.mit.edu	37	12	49523090	49523091	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr12:49523090_49523091delCA	ENST00000336023.5	-	3	403_404	c.309_310delTG	c.(307-312)tatgccfs	p.A104fs	RP11-386G11.10_ENST00000547387.1_RNA	NM_006082.2	NP_006073.2	P68363	TBA1B_HUMAN	tubulin, alpha 1b	104					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding			breast(2)|cervix(1)|endometrium(3)|large_intestine(2)|lung(4)	12						TGCCCTCGGGCATAGTTATTGG	0.505													16	171	---	---	---	---					
ANO4	121601	broad.mit.edu	37	12	101493425	101493425	+	Frame_Shift_Del	DEL	C	C	-			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr12:101493425delC	ENST00000392979.3	+	21	2332	c.1971delC	c.(1969-1971)ttcfs	p.F657fs	ANO4_ENST00000299222.9_Frame_Shift_Del_p.F212fs|ANO4_ENST00000392977.3_Frame_Shift_Del_p.F692fs|ANO4_ENST00000550015.1_Frame_Shift_Del_p.F212fs	NM_178826.3	NP_849148.2	Q32M45	ANO4_HUMAN	anoctamin 4	692						chloride channel complex	chloride channel activity	p.F657F(1)		NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						AAATAAGTTTCCCACAATGGG	0.348										HNSCC(74;0.22)			15	73	---	---	---	---					
OAS2	4939	broad.mit.edu	37	12	113425052	113425052	+	Frame_Shift_Del	DEL	C	C	-			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr12:113425052delC	ENST00000392583.2	+	2	594	c.387delC	c.(385-387)atcfs	p.I129fs	OAS2_ENST00000449768.2_Frame_Shift_Del_p.I129fs|OAS2_ENST00000342315.4_Frame_Shift_Del_p.I129fs|RP1-71H24.1_ENST00000552784.1_RNA	NM_002535.2	NP_002526.2	P29728	OAS2_HUMAN	2'-5'-oligoadenylate synthetase 2, 69/71kDa	129	OAS domain 1.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|membrane|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding			NS(1)|breast(2)|endometrium(4)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	28						GGTTCACCATCCAGGTGTTCA	0.458													23	81	---	---	---	---					
NPIPA5	100288332	broad.mit.edu	37	16	15457565	15457566	+	Frame_Shift_Del	DEL	AC	AC	-			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr16:15457565_15457566delAC	ENST00000360151.4	-	8	1002_1003	c.1003_1004delGT	c.(1003-1005)gtcfs	p.V335fs		NM_001277325.1	NP_001264254.1			nuclear pore complex interacting protein family, member A5																		GAGTGAGCAGACACACTCGGGA	0.446													4	5	---	---	---	---					
FRG1B	284802	broad.mit.edu	37	20	29628310	29628312	+	In_Frame_Del	DEL	AGG	AGG	-	rs111939959		TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr20:29628310_29628312delAGG	ENST00000278882.3	+	6	692_694	c.312_314delAGG	c.(310-315)gcagga>gca	p.G105del	FRG1B_ENST00000358464.4_In_Frame_Del_p.G105del|FRG1B_ENST00000439954.2_In_Frame_Del_p.G110del																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GTAAAACAGCAGGAGAAGAAGAA	0.355													7	125	---	---	---	---					
ANKRD20A11P	391267	broad.mit.edu	37	21	15343746	15343749	+	RNA	DEL	TCTG	TCTG	-			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr21:15343746_15343749delTCTG	ENST00000344693.5	-	0	736					NR_027270.1																						CTCTGTGCTTTCTGATGTGCTGCT	0.407													3	5	---	---	---	---					
ARFGAP3	26286	broad.mit.edu	37	22	43213780	43213780	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FD-A62S-01A-11D-A30E-08	TCGA-FD-A62S-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	628700b5-b42c-42c9-8500-e7df34090fee	fa37b9d1-5ad5-4cea-b91a-d232f4e9e318	g.chr22:43213780delT	ENST00000263245.5	-	10	1115	c.896delA	c.(895-897)aatfs	p.N299fs	ARFGAP3_ENST00000437119.2_Frame_Shift_Del_p.N255fs|ARFGAP3_ENST00000429508.2_Frame_Shift_Del_p.N227fs	NM_001142293.1|NM_014570.4	NP_001135765.1|NP_055385.3	Q9NP61	ARFG3_HUMAN	ADP-ribosylation factor GTPase activating protein 3	299					intracellular protein transport|protein secretion|regulation of ARF GTPase activity|vesicle-mediated transport	cytosol|Golgi membrane	ARF GTPase activator activity|protein transporter activity|zinc ion binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|ovary(1)	11						TGAGTCAACATTTTTTTTGCC	0.363													9	172	---	---	---	---